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Sample records for dysprosium 140

  1. Dysprosium magneto-optical traps

    CERN Document Server

    Youn, Seo Ho; Ray, Ushnish; Lev, Benjamin L

    2010-01-01

    Magneto-optical traps (MOTs) of highly magnetic lanthanides open the door to explorations of novel phases of strongly correlated matter such as lattice supersolids and quantum liquid crystals. We recently reported the first MOTs of the five high abundance isotopes of the most magnetic atom, dysprosium. Described here are details of the experimental technique employed for repumper-free Dy MOTs containing up to half a billion atoms. Extensive characterization of the MOTs' properties---population, temperature, loading, metastable decay dynamics, trap dynamics---is provided.

  2. On polymorphism of dysprosium trichloride

    Energy Technology Data Exchange (ETDEWEB)

    Zakiryanova, Irina D.; Khokhlov, Vladimir A.; Salyulev, Alexander B.; Korzun, Iraida V. [RAS Ural Branch, Ekaterinburg (Russian Federation). Institute of High-Temperature Electrochemistry

    2015-07-01

    For the first time, the structure of crystalline DyCl{sub 3} over a wide temperature range from room temperature to melting point was studied by Raman spectroscopy. The phonon modes (cm{sup -1}) of dysprosium trichloride (monoclinic crystal lattice of AlCl{sub 3} type, Z = 4, CN = 6) at room temperature are 257 (A{sub 1g}), 201 (E{sub g}), 112 (E{sub g}), 88 (A{sub 1g}), and 63 (E{sub g}). The monoclinic structure of the crystalline DyCl{sub 3} C{sub 2h}{sup 3} symmetry was found to remain constant over the studied temperature range. No polymorphic transformation in the solid state was detected. Gravimetry, calorimetry, and mass spectrometry have been used in addition to support the conclusions made on the basis of Raman spectroscopic data.

  3. Resonance ionization spectroscopy in dysprosium

    Energy Technology Data Exchange (ETDEWEB)

    Studer, D., E-mail: dstuder@uni-mainz.de; Dyrauf, P.; Naubereit, P.; Heinke, R.; Wendt, K. [Johannes Gutenberg-Universität Mainz, Institut für Physik (Germany)

    2017-11-15

    We report on resonance ionization spectroscopy (RIS) of high-lying energy levels in dysprosium. We developed efficient excitation schemes and re-determined the first ionization potential (IP) via analysis of Rydberg convergences. For this purpose both two- and three-step excitation ladders were investigated. An overall ionization efficiency of 25(4) % could be demonstrated in the RISIKO mass separator of Mainz University, using a three-step resonance ionization scheme. Moreover, an extensive analysis of the even-parity 6sns- and 6snd-Rydberg-series convergences, measured via two-step excitation was performed. To account for strong perturbations in the observed s-series, the approach of multichannel quantum defect theory (MQDT) was applied. Considering all individual series limits we extracted an IP-value of 47901.76(5) cm{sup −1}, which agrees with the current literature value of 47901.7(6) cm{sup −1}, but is one order of magnitude more precise.

  4. The dysprosium-tin phase diagram

    Energy Technology Data Exchange (ETDEWEB)

    Eremenko, V.N.; Bulanova, M.V.; Martsenjuk, P.S. (I.N. Frantsevich Inst. for Problems of Materials Science, Kiev (Ukraine))

    1992-12-07

    The dysprosium-tin phase diagram was established by means of differential thermal, X-ray and microscopic analyses of 22 alloys. Seven intermetallic compounds were found to exist in the system. Dy[sub 5]Sn[sub 3] melts congruently at 1870 degC, and undergoes a polymorphous transformation at 1823 [+-] 6 degC. The intermetallics Dy[sub 5]Sn[sub 4], Dy[sub 11]Sn[sub 10], DySn, Dy[sub 4]Sn[sub 5], DySn[sub 2], DySn[sub 3] are formed peritectically at 1712 [+-]11, 1605 [+-]12, 1208 [+-]3, 1166 [+-]7, 1138 [+-]3 and 747 [+-]6 degC respectively. DySn[sub 3] exists in a narrow temperature range, in two polymorphous modifications. The transformation [beta]-DySn[sub 3] [yields] [alpha]-DySn[sub 3] occurs at 608 [+-] 12 degC, and at 499 [+-]2 degC [alpha]-DySn[sub 3] decomposes to DySn[sub 2] and the tin-rich melt. The dysprosium-rich eutectic crystallizes at 1204 [+-]10 degC and contains 13 at.% tin. The solid-state solubility of tin in dysprosium is about 3 at.%, and that of dysprosium in tin is negligible.

  5. Towards a new measurement of parity violation in dysprosium

    CERN Document Server

    Leefer, N; Antypas, D; Budker, D

    2014-01-01

    The dysprosium parity violation experiment concluded nearly 17 years ago with an upper limit on weak interaction induced mixing of nearly degenerate, opposite parity states in atomic dysprosium. While that experiment was limited in sensitivity by statistics, a new apparatus constructed in the interim for radio-frequency spectroscopy is expected to provide significant improvements to the statistical sensitivity. Preliminary work from the new PV experiment in dysprosium is presented with a discussion of the current statistical sensitivity and outlook.

  6. Dysprosium Modification of Cobalt Ferrite Ionic Magnetic Fluids

    Institute of Scientific and Technical Information of China (English)

    JIANG Rong-li; LIU Yong-chao; GENG Quan-rong; ZHAO Wen-tao

    2005-01-01

    Dysprosium composite cobalt ferrite ionic magnetic fluids were prepared by precipitation in the presence of Tri-sodium citrate. Influence of dysprosium modification on magnetic property is studied. The result shows that magnetic response toward exterior magnetic field can be improved by adding Dy3+. Studies also show that the increase of reaction temperature may improve the modification effect of dysprosium. By adding dysprosium ions, the average diameter of the magnetic nanoparticles will be decreased evidently. It is clear that the particles appear as balls, Cobalt ferrite with sizes of 12-15 nm, rare earth composite cobalt ferrite with sizes of 6-8 nm.

  7. Can a dysprosium shortage threaten green energy technologies?

    NARCIS (Netherlands)

    Hoenderdaal, S.; Tercero Espinoza, L.; Marschneider-Weidemann, F.; Crijns - Graus, Wina

    2013-01-01

    Dysprosium, one of the various rare earth elements, is currently for more than 99% mined in China. As China is reducing its exports, new mining projects outside of China are needed to sustain supply and meet future demands. Dysprosium is mainly used in permanent magnets to retain the magnet's streng

  8. Phenalenyl-based mononuclear dysprosium complexes

    Directory of Open Access Journals (Sweden)

    Yanhua Lan

    2016-07-01

    Full Text Available The phenalenyl-based dysprosium complexes [Dy(PLN2(HPLNCl(EtOH] (1, [Dy(PLN3(HPLN]·[Dy(PLN3(EtOH]·2EtOH (2 and [Dy(PLN3(H2O2]·H2O (3, HPLN being 9-hydroxy-1H-phenalen-1-one, have been synthesized. All compounds were fully characterized by means of single crystal X-ray analysis, paramagnetic 1H NMR, MALDI-TOF mass spectrometry, UV–vis spectrophotometry and magnetic measurements. Both static (dc and dynamic (ac magnetic properties of these complexes have been investigated, showing slow relaxation of magnetization, indicative of single molecule magnet (SMM behavior. Attempts to synthesize sublimable phenalenyl-based dysprosium complexes have been made by implementing a synthetic strategy under anhydrous conditions. The sublimed species were characterized and their thermal stability was confirmed. This opens up the possibility to deposit phenalenyl-based lanthanides complexes by sublimation onto surfaces, an important prerequisite for ongoing studies in molecular spintronics.

  9. Anisotropy in the Interaction of Ultracold Dysprosium

    CERN Document Server

    Kotochigova, Svetlana

    2011-01-01

    The nature of the interaction between ultracold atoms with a large orbital and spin angular momentum has attracted considerable attention. It was suggested that such interactions can lead to the realization of exotic states of highly correlated matter. Here, we report on a theoretical study of the competing anisotropic dispersion, magnetic dipole-dipole, and electric quadrupole-quadrupole forces between two dysprosium atoms. Each dysprosium atom has an orbital angular momentum L=6 and magnetic moment $\\mu=10\\mu_B$. We show that the dispersion coefficients of the ground state adiabatic potentials lie between 1865 a.u. and 1890 a.u., creating a non-negligible anisotropy with a spread of 25 a.u. and that the electric quadrupole-quadrupole interaction is weak compared to the other interactions. We also find that for interatomic separations $R< 50\\,a_0$ both the anisotropic dispersion and magnetic dipole-dipole potential are larger than the atomic Zeeman splittings for external magnetic fields of order 10 G to ...

  10. First search for double $\\beta$ decay of dysprosium

    CERN Document Server

    Belli, P; Cappella, F; Cerulli, R; Danevich, F A; d'Angelo, S; Di Vacri, M L; Incicchitti, A; Laubenstein, M; Nagorny, S S; Nisi, S; Tolmachev, A V; Tretyak, V I; Yavetskiy, R P

    2011-01-01

    A search for double $\\beta$ decay of dysprosium was realized for the first time with the help of an ultra low-background HP Ge $\\gamma$ detector. After 2512 h of data taking with a 322 g sample of dysprosium oxide limits on double beta processes in $^{156}$Dy and $^{158}$Dy have been established on the level of $T_{1/2}\\geq 10^{14}-10^{16}$ yr. Possible resonant double electron captures in $^{156}$Dy and $^{158}$Dy were restricted on a similar level. As a by-product of the experiment we have measured the radioactive contamination of the Dy$_2$O$_3$ sample and set limits on the $\\alpha$ decay of dysprosium isotopes to the excited levels of daughter nuclei as $T_{1/2}\\geq 10^{15} - 10^{17}$ yr.

  11. Neutron resonance parameters of dysprosium isotopes using neutron capture yields

    Energy Technology Data Exchange (ETDEWEB)

    Shin, S. G.; Kye, Y. U.; Cho, M. H. [POSTECH, Pohang (Korea, Republic of); Namkung, W. [Pohang Accelerator Laboratory, Pohang (Korea, Republic of); Kim, G. N. [Kyungpook National University, Daegu (Korea, Republic of); Lee, M. W.; Kang, Y. R. [Dongnam Inst. Of Radiological and Medical Science, Busan (Korea, Republic of)

    2015-10-15

    Dysprosium is used in the field of nuclear reactor system because it has a very large thermal neutron absorption cross-section. The dysprosium alloyed with special stainless steels is attractive for control in nuclear reactor because of the ability to absorb neutrons readily without swelling or contracting over time and its high melting point. Dysprosium is also one of fission products from the thermal fission of {sup 234}U, {sup 233}U, and {sup 239}Pu. The fission products are accumulated in the reactor core by the burn-up of the nuclear fuel and the poison effect is increased. Therefore, it is required to understand how Dysprosium as both a poison and an absorbing material in the control rod has an effect on the neutron population in a nuclear reactor system over all energy regions. Neutron Capture experiments on Dy isotopes were performed at the electron linear accelerator (LINAC) facility of the Rensselear Polytechnic Institute (RPI) in the neutron energy region from 10 eV to 1 keV. Resonance parameters were extracted by fitting the neutron capture data using the SAMMY multilevel R-matrix Bayesian code.

  12. Properties of Polydisperse Tin-doped Dysprosium and Indium Oxides

    Directory of Open Access Journals (Sweden)

    Malinovskaya Tatyana

    2017-01-01

    Full Text Available The results of investigations of the complex permittivity, diffuse-reflectance, and characteristics of crystal lattices of tin-doped indium and dysprosium oxides are presented. Using the methods of spectroscopy and X-ray diffraction analysis, it is shown that doping of indium oxide with tin results in a significant increase of the components of the indium oxide complex permittivity and an appearance of the plasma resonance in its diffuse-reflectance spectra. This indicates the appearance of charge carriers with the concentration of more than 1021 cm−3 in the materials. On the other hand, doping of the dysprosium oxide with the same amount of tin has no effect on its optical and electromagnetic properties.

  13. Dysprosium titanate as an absorber material for control rods

    Science.gov (United States)

    Risovany, V. D.; Varlashova, E. E.; Suslov, D. N.

    2000-09-01

    Disprosium titanate is an attractive control rod material for the thermal neutron reactors. Its main advantages are: insignificant swelling, no out-gassing under neutron irradiation, rather high neutron efficiency, a high melting point (˜1870°C), non-interaction with the cladding at temperatures above 1000°C, simple fabrication and easily reprocessed non-radioactive waste. It can be used in control rods as pellets and powder. The disprosium titanate control rods have worked off in the MIR reactor for 17 years, in VVER-1000 - for 4 years without any operating problems. After post-irradiation examinations this type of control rod having high lifetime was recommended for the VVER and RBMK. The paper presents the examination results of absorber element dummies containing dysprosium titanate, irradiated in the SM reactor to the neutron fluence of 3.4×10 22 cm -2 ( E>0.1 MeV) and, also, the data on structure, thermal-physical properties of dysprosium titanate, efficiency of dysprosium titanate control rods.

  14. Dysprosium electrodeposition from a hexaalkylguanidinium-based ionic liquid

    Science.gov (United States)

    Berger, Claudia A.; Arkhipova, Maria; Maas, Gerhard; Jacob, Timo

    2016-07-01

    The rare-earth element dysprosium (Dy) is an important additive that increases the magnetocrystalline anisotropy of neodymium magnets and additionally prevents from demagnetizing at high temperatures. Therefore, it is one of the most important elements for high-tech industries and is mainly used in permanent magnetic applications, for example in electric vehicles, industrial motors and direct-drive wind turbines. In an effort to develop a more efficient electrochemical technique for depositing Dy on Nd-magnets in contrast to commonly used costly physical vapor deposition, we investigated the electrochemical behavior of dysprosium(iii) trifluoromethanesulfonate in a custom-made guanidinium-based room-temperature ionic liquid (RTIL). We first examined the electrodeposition of Dy on an Au(111) model electrode. The investigation was carried out by means of cyclic voltammetry (CV) and X-ray photoelectron spectroscopy (XPS). The initial stages of metal deposition were followed by in situ scanning tunneling microscopy (STM). CV measurements revealed a large cathodic reduction peak, which corresponds to the growth of monoatomic high islands, based on STM images taken during the initial stages of deposition. XPS identified these deposited islands as dysprosium. A similar reduction peak was also observed on an Nd-Fe-B substrate, and positively identified as deposited Dy using XPS. Finally, we varied the concentration of the Dy precursor, electrolyte flow and temperature during Dy deposition and demonstrated that each of these parameters could be used to increase the thickness of the Dy deposit, suggesting that these parameters could be tuned simultaneously in a temperature-controlled flow cell to enhance the thickness of the Dy layer.The rare-earth element dysprosium (Dy) is an important additive that increases the magnetocrystalline anisotropy of neodymium magnets and additionally prevents from demagnetizing at high temperatures. Therefore, it is one of the most important

  15. Dysprosium detector for neutron dosimetry in external beam radiotherapy

    Science.gov (United States)

    Ostinelli, A.; Berlusconi, C.; Conti, V.; Duchini, M.; Gelosa, S.; Guallini, F.; Vallazza, E.; Prest, M.

    2014-09-01

    Radiotherapy treatments with high-energy (>8 MeV) photon beams are a standard procedure in clinical practice, given the skin and near-target volumes sparing effect, the accurate penetration and the uniform spatial dose distribution. On the other hand, despite these advantages, neutrons may be produced via the photo-nuclear (γ,n) reactions of the high-energy photons with the high-Z materials in the accelerator head, in the treatment room and in the patient, resulting in an unwanted dose contribution which is of concern, given its potential to induce secondary cancers, and which has to be monitored. This work presents the design and the test of a portable Dysprosium dosimeter to be used during clinical treatments to estimate the "in vivo" dose to the patient. The dosimeter has been characterized and validated with tissue-equivalent phantom studies with a Varian Clinical iX 18 MV photon beam, before using it with a group of patients treated at the S. Anna Hospital in Como. The working principle of the dosimeter together with the readout chain and the results in terms of delivered dose are presented.

  16. Dysprosium detector for neutron dosimetry in external beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ostinelli, A.; Berlusconi, C.; Conti, V.; Duchini, M.; Gelosa, S. [Medical Physics - Sant' Anna Hospital, Como (Italy); Guallini, F. [EL.SE s.r.l. (Italy); Vallazza, E. [INFN, Trieste (Italy); Prest, M. [University of Insubria, Como (Italy)

    2014-09-21

    Radiotherapy treatments with high-energy (>8MeV) photon beams are a standard procedure in clinical practice, given the skin and near-target volumes sparing effect, the accurate penetration and the uniform spatial dose distribution. On the other hand, despite these advantages, neutrons may be produced via the photo-nuclear (γ,n) reactions of the high-energy photons with the high-Z materials in the accelerator head, in the treatment room and in the patient, resulting in an unwanted dose contribution which is of concern, given its potential to induce secondary cancers, and which has to be monitored. This work presents the design and the test of a portable Dysprosium dosimeter to be used during clinical treatments to estimate the “in vivo” dose to the patient. The dosimeter has been characterized and validated with tissue-equivalent phantom studies with a Varian Clinical iX 18 MV photon beam, before using it with a group of patients treated at the S. Anna Hospital in Como. The working principle of the dosimeter together with the readout chain and the results in terms of delivered dose are presented.

  17. Low Field Magnetic and Thermal Hysteresis in Antiferromagnetic Dysprosium

    Directory of Open Access Journals (Sweden)

    Iuliia Liubimova

    2017-06-01

    Full Text Available Magnetic and thermal hysteresis (difference in magnetic properties on cooling and heating have been studied in polycrystalline Dy (dysprosium between 80 and 250 K using measurements of the reversible Villari effect and alternating current (AC susceptibility. We argue that measurement of the reversible Villari effect in the antiferromagnetic phase is a more sensitive method to detect magnetic hysteresis than the registration of conventional B(H loops. We found that the Villari point, recently reported in the antiferromagnetic phase of Dy at 166 K, controls the essential features of magnetic hysteresis and AC susceptibility on heating from the ferromagnetic state: (i thermal hysteresis in AC susceptibility and in the reversible Villari effect disappears abruptly at the temperature of the Villari point; (ii the imaginary part of AC susceptibility is strongly frequency dependent, but only up to the temperature of the Villari point; (iii the imaginary part of the susceptibility drops sharply also at the Villari point. We attribute these effects observed at the Villari point to the disappearance of the residual ferromagnetic phase. The strong influence of the Villari point on several magnetic properties allows this temperature to be ranked almost as important as the Curie and Néel temperatures in Dy and likely also for other rare earth elements and their alloys.

  18. A Low-Symmetry Dysprosium Metallocene Single-Molecule Magnet with a High Anisotropy Barrier.

    Science.gov (United States)

    Pugh, Thomas; Chilton, Nicholas F; Layfield, Richard A

    2016-09-05

    The single-molecule magnet (SMM) properties of the isocarbonyl-ligated dysprosium metallocene [Cp*2 Dy{μ-(OC)2 FeCp}]2 (1Dy ), which contains a rhombus-shaped Dy2 Fe2 core, are described. Combining a strong axial [Cp*](-) ligand field with a weak equatorial field consisting of the isocarbonyl ligands leads to an anisotropy barrier of 662 cm(-1) in zero applied field. The dominant thermal relaxation pathways in 1Dy involves at least the fourth-excited Kramers doublet, thus demonstrating that prominent SMM behavior can be observed for dysprosium in low-symmetry environments.

  19. Malonate complexes of dysprosium: synthesis, characterization and application for LI-MOCVD of dysprosium containing thin films.

    Science.gov (United States)

    Milanov, Andrian P; Seidel, Rüdiger W; Barreca, Davide; Gasparotto, Alberto; Winter, Manuela; Feydt, Jürgen; Irsen, Stephan; Becker, Hans-Werner; Devi, Anjana

    2011-01-07

    A series of malonate complexes of dysprosium were synthesized as potential metalorganic precursors for Dy containing oxide thin films using chemical vapor deposition (CVD) related techniques. The steric bulkiness of the dialkylmalonato ligand employed was systematically varied and its influence on the resulting structural and physico-chemical properties that is relevant for MOCVD was studied. Single crystal X-ray diffraction analysis revealed that the five homoleptic tris-malonato Dy complexes (1-5) are dimers with distorted square-face bicapped trigonal-prismatic geometry and a coordination number of eight. In an attempt to decrease the nuclearity and increase the solubility of the complexes in various solvents, the focus was to react these dimeric complexes with Lewis bases such as 2,2'-biypridyl and pyridine (6-9). This resulted in monomeric tris-malonato mono Lewis base adduct complexes with improved thermal properties. Finally considering the ease of synthesis, the monomeric nature and promising thermal characteristics, the silymalonate adduct complex [Dy(dsml)(3)bipy] (8) was selected as single source precursor for growing DySi(x)O(y) thin films by liquid injection metalorganic chemical vapor deposition (LI-MOCVD) process. The as-deposited films were analyzed for their morphology and composition by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, Rutherford backscattering (RBS) analysis and X-ray photoelectron spectroscopy.

  20. Exploration of dysprosium: the most critical element for Japan

    Science.gov (United States)

    Watanabe, Y.

    2012-04-01

    Dysprosium (Dy), one of the heavy rare earth elements, is used mainly as an additive for NdFeB permanent magnets which are installed in various modern industrial products such as voice coil motors in computers, factory automation machinery, hybrid and electric vehicles, home electronics, and wind turbine, to improve heat resistance of the magnets. Dy has been produced about 2,000t per year from the ores from ion adsorption type deposits in southern China. However, the produced amount of Dy was significantly reduced in 2011 in China due to reservation of heavy rare earth resources and protection of natural environment, resulting in soaring of Dy price in the world. In order to respond the increasing demand of Dy, unconventional supply sources are inevitably developed, in addition to heavy rare earth enriched ion adsorption type deposits outside China. Heavy rare earth elements including Dy are dominantly hosted in xenotime, fergusonite, zircon, eudialyte, keiviite, kainosite, iimoriite, etc. Concentration of xenotime is found in placer deposits in Malaysia and India, hydrothermal deposits associated with unconformity-type uranium mineralization (Athabasca basin in Canada, Western Australia), iron-oxide fluorite mineralization (South Africa) and Sn-bearing alkaline granite (Brazil). Zircon and fergusontie concentration is found as igneous and hydrothermal products in peralkaline syenite, alkaline granite and pegmatite (e.g., Nechalacho in Canada). Eudialyte concentration is found in some peralkaline syenite bodies in Greenland, Canada, Sweden and Russia. Among these sources, large Dy resources are estimated in the deposits hosted in peralkaline rocks (Nechalacho: 79,000t, Kvanefjeld: 49,000t, Norra Karr: 15,700t, etc.) compared to the present demand of Dy. Thus, Dy will be supplied from the deposits associated with peralkaline and alkaline deposits in future instead of ion adsorption type deposits in southern China.

  1. Long afterglow of trivalent dysprosium doped strontium aluminate

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Yuan Ming, E-mail: dongshanisland@126.com [School of Mathematics and Physics, Changzhou University, Jiangsu 213164 (China); Ma, Qing-lan [School of Mathematics and Physics, Changzhou University, Jiangsu 213164 (China); School of Electronics and Information, Nantong University, Jiangsu 226019 (China)

    2015-04-15

    Trivalent dysprosium doped strontium aluminate (SrA1{sub 2}O{sub 4}:Dy{sup 3+}) was synthesized via the sol–gel combustion method to realize green afterglow in the absence of Eu{sup 2+} luminescent centers. The morphology, crystal structure, photoluminescence and long afterglow of the SrAl{sub 2}O{sub 4}:Dy{sup 3+} were characterized with scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy and photoluminescence spectroscopy, respectively. The bluish-green photoluminescence of SrAl{sub 2}O{sub 4}:Dy{sup 3+} consists of a broad emission band centered at about 520 nm and two characteristic emissions of Dy{sup 3+} ions centered at 480 and 575 nm, respectively. The green afterglow of SrAl{sub 2}O{sub 4}:Dy{sup 3+} is a broad emission band centered at around 520 nm, and the lifetime extracted from afterglow decay is found to be 53 s. The mechanism on the green afterglow from SrAl{sub 2}O{sub 4}:Dy{sup 3+} is discussed in terms of the possible defect levels in the host. - Highlights: • Broad band long-lasting afterglow is observed in SrAl{sub 2}O{sub 4}:Dy{sup 3+} phosphors. • Characteristic emissions of Dy{sup 3+} ions are superimposed on the broad PL of phosphors. • Dy{sup 3+} ions can also act as luminescent centers in addition to electron traps. • A mechanism on long afterglow of SrAl{sub 2}O{sub 4}:Dy{sup 3+} is proposed without Eu{sup 2+} activator.

  2. Low temperature spin reorientation in dysprosium iron garnet

    Energy Technology Data Exchange (ETDEWEB)

    Lahoubi, M; Younsi, W; Soltani, M L [Department of Physics, Badji-Mokhtar University, BP-12 Annaba, 23000 (Algeria); Voiron, J; Schmitt, D, E-mail: mlahoubi@gmail.co [Louis Neel Laboratory, CNRS-UJF, BP-166, 38042 Grenoble Cedex 9 (France)

    2009-03-01

    The spin reorientation (SR) phase transition in dysprosium iron garnet (Dy{sub 3}Fe{sub 5}O{sub 12} or DyIG) have been studied by specific heat C{sub p}(T) and high field magnetisation measurements M{sub T}(H) and M{sub H}(T) on single crystals at low temperature. A first order SR is observed with a sharp jump at T{sub SR} = 14.5+-0.5 K in the C{sub p}(T) curve which corresponds to a spontaneous change from the high temperature (HT) easy direction (111) to an (uuw) angular low temperature (LT) phases. Above T{sub SR}, the magnetic structure is described by the irreducible representation (IR) A{sub 2g} of the rhombohedral space group R 3 c. Below T{sub SR}, the magnetic structure changes in the monoclinic the space group C2/c with the IR A{sub g}. When the field H is kept aligned along the hard symmetry directions (100) and (110), we obtain respectively the variation of the angular positions theta(T) and theta'(T) from the total spontaneous magnetisation down to 1.5 K (theta = 39.23 deg. and theta' = 30.14 deg.) and the results are in good agreement with the previous observations in low fields. When the sample is allowed to rotate freely on itself, the critical field H{sub c}(T) between the HT(111) and the LT(uuw) angular phases permits us to precise the transition line up to 15 T and 40 K between the so called canted field induced (FI) and the associated collinear magnetic phases. The experimental magnetic phase diagram (MPD) is precisely determined in the (H{sub c}-T) plane and the domains of the existence and the stability of the two magnetic phases are specified.

  3. Anisotropic magnetic properties of dysprosium iron garnet (DyIG)

    Energy Technology Data Exchange (ETDEWEB)

    Lahoubi, M; Younsi, W; Soltani, M-L [Department of Physics, Badji-Mokhtar University, BP 12 - 23000 Annaba (Algeria); Ouladdiaf, B, E-mail: mlahoubi@gmail.co [Institut Laue Langevin, BP 156 - 38042 Grenoble Cedex 9 (France)

    2010-01-01

    The magnetic properties of dysprosium iron garnet (DyIG) have been studied by performing high resolution powder neutron diffraction experiments and high dc fields magnetizations on single crystals. Among all the reflections (hkl) indexed in the nuclear cubic space group (CSG) Ia 3-bar d with h+k+l=2n and k=[000], the superstructure lines (hkl)* forbidden by the symmetry (222)* and (622)* are not observed in the patterns at all temperatures. The pattern at 130 K is well interpreted within the magnetic modes F belonging to the irreducible representation (IR) T{sub 1g} of the CSG and identified to the room temperature ferrimagnetic Neel model. The high magnetic field behavior of the spontaneous collinear magnetic structure (MS) along the easy axis (EA) <111> is isotropic. Below 130 K, the patterns exhibit additional magnetic superstructure lines. They are associated to the appearance of the spontaneous non collinear MS which is described in the subgroup of the CSG, R 3-bar c within the IR A{sub 2g}. A strong magnetization anisotropy (MA) is observed at 1.5 K in the low symmetry phases were the spin reorientation transition (SR) occur at T{sub RS}=14.5 K. The onset of MA is detected below two characteristic temperatures, Ta{sub 1}=125 K and Ta{sub 2}=75 K respectively to the hard axis (HA) <100> and <110>. Symmetry arguments are used in the framework of the theory of representation analysis (RA) applied to the subgroup of R 3-bar c, C2/c within the IR A{sub g}. It seems that this MA results essentially from the difference between the spontaneous non collinear MS and the field induced (FI) configurations. All results are discussed with previous neutrons studies.

  4. Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems

    KAUST Repository

    Arratia-Quijada, Jenny

    2015-10-23

    A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nanoparticles showed a linear relationship with the reciprocal relaxation spin-lattice (T1) time of water protons which is reflected as contrast in aqueous suspensions analyzed by magnetic resonance imaging. The interlayer space of dysprosium containing LDH was successfully intercalated with folate, ibuprofen and gallate ions, which are key molecules for recognition of some cancer cells and treatment of diseases. The paramagnetic property of the dysprosium-containing LDH detected in this work beside the ability to transport drugs open up the opportunity to design theranostic materials in a single crystal phase with nanometric dimensions.

  5. Effects of Dysprosium Oxide Doping on Microstructure and Properties of Barium Titanate Ceramic

    Institute of Scientific and Technical Information of China (English)

    Pu Yongping; Ren Huijun; Chen Wei; Chen Shoutian

    2005-01-01

    Different amounts of dysprosium oxide were incorporated into barium titanate powders synthesized by hydrothermal method. Relations of substitution behaviors and lattice parameters with solid-solubility were studied. Furthermore, the influences of dysprosium oxide doping fraction on grain size and dielectric properties of barium titanate ceramic, including dielectric constant and breakdown electric field strength, were investigated via scanning electron microscope, X-ray diffraction and electric property tester. The results show that dysprosium oxide can restrain abnormal grain growth during sintering and that fine-grained and high density of barium titanate ceramic can result in excellent dielectric properties. As mass fraction of dysprosium oxide is 0.6%, the lattice parameters of grain increase to the maximum because of the lowest vacancy concentration. The electric property parameters are cited as following: dielectric constant (25 ℃) reaches 4100, the change in relative dielectric constant with temperature is -10% to 10% within the range of -15~100 ℃, breakdown electric field strength (alternating current) achieves 3.2 kV·mm-1, which can be used in manufacturing high voltage ceramic capacitors.

  6. Sandwich-type tetrakis(phthalocyaninato) dysprosium-cadmium quadruple-decker SMM.

    Science.gov (United States)

    Wang, Hailong; Qian, Kang; Wang, Kang; Bian, Yongzhong; Jiang, Jianzhuang; Gao, Song

    2011-09-14

    Homoleptic tetrakis[2,3,9,10,16,17,23,24-octa(butyloxy)phthalocyaninato] dysprosium-cadmium quadruple-decker complex 1 was isolated in relatively good yield of 43% from a simple one-pot reaction. This compound represents the first sandwich-type tetrakis(phthalocyaninato) rare earth-cadmium quadruple-decker SMM that has been structurally characterized.

  7. In situ characterization of the nitridation of dysprosium during mechanochemical processing

    Energy Technology Data Exchange (ETDEWEB)

    Jaques, Brian J.; Osterberg, Daniel D.; Alanko, Gordon A.; Tamrakar, Sumit; Smith, Cole R.; Hurley, Michael F.; Butt, Darryl P., E-mail: DarrylButt@BoiseState.edu

    2015-01-15

    Highlights: • A nitridation reaction in a high energy planetary ball mill was monitored in situ. • Dysprosium mononitride was synthesized from Dy at low temperatures in short times. • Ideal gas law and in situ temperature and pressure used to assess reaction extent. • It is proposed that reaction rate is proportional to the creation of new surface. - Abstract: Processing of advanced nitride ceramics traditionally requires long durations at high temperatures and, in some cases, in hazardous atmospheres. In this study, dysprosium mononitride (DyN) was rapidly formed from elemental dysprosium in a closed system at ambient temperatures. An experimental procedure was developed to quantify the progress of the nitridation reaction during mechanochemical processing in a high energy planetary ball mill (HEBM) as a function of milling time and intensity using in situ temperature and pressure measurements, SEM, XRD, and particle size analysis. No intermediate phases were formed. It was found that the creation of fresh dysprosium surfaces dictates the rate of the nitridation reaction, which is a function of milling intensity and the number of milling media. These results show clearly that high purity nitrides can be synthesized with short processing times at low temperatures in a closed system requiring a relatively small processing footprint.

  8. Dysprosium complexes with the tetraphenylporphyrin macrocyclic ligand; Complejos de disprosio con el ligante macrociclico tetrafenilporfirina

    Energy Technology Data Exchange (ETDEWEB)

    Martinez M, V.; Padilla, J.; Ramirez, F.M

    1992-04-15

    In this report, the results obtained on the synthesis, characterization and study of the chemical behavior of dysprosium complex with the acetylacetone chelating agent (Hacac) and the tetraphenylporphyrin macrocyclic ligand (H{sub 2}TFP) are given. Based on the literature but according to our necessities and interest, the appropriate methodology settled down from the synthesis of prime matters until the obtaining and characterization of the products. The acetyl acetonate complex was obtained of mono hydrated dysprosium [Dy(acac){sub 3}. H{sub 2}0] and trihydrated [Dy(acac){sub 3} .3 H{sub 2}0], the mono tetra phenyl porphyrinate [Dy(TFP)(acac). 2 ac] the double sandwich of the dysprosium porphyrinate [Dy(TFP){sub 2}] and the triple sandwich of the dysprosium porphyrinate [Dy(TFP){sub 3}. 2 TCB] (TCB = trichlorobenzene). Its were characterized by their melting points, solubility, IR, UV, TGA and DTA both first and besides the techniques already mentioned for NMR'H, RPE and Magnetic susceptibility the three last complexes. From the spectroscopic point of view, IR and RPE its suggested the existence of a complex of inverse mixed valence [Dy(TFP){sup 2-} (TFP) {sup 1-}] for the Dy(TFP){sub 2} as a result of the existence of the free radical (TFP' {sup 1-} and that it was not in none of the other porphyrin compounds. In the NMR'H spectra of the compounds were not observed signals in the region from 0 to 10 ppm that which shows that the dysprosium complexes in special those of the porphyrin type are highly paramagnetic and its could be used as displacement reagents, creators of images and contrast agents of great utility in these days in studies of NMR, technique today by today used in medical diagnoses. (Author)

  9. Synthesis, structural characterization and in vitro testing of dysprosium containing silica particles as potential MRI contrast enhancing agents

    Science.gov (United States)

    Chiriac, L. B.; Trandafir, D. L.; Turcu, R. V. F.; Todea, M.; Simon, S.

    2016-11-01

    The work is focused on synthesis and structural characterization of novel dysprosium-doped silica particles which could be considered as MRI contrast agents. Sol-gel derived silica rich particles obtained via freeze-drying and spray-drying processing methods were structurally characterized by XRD, 29Si MAS-NMR and XPS methods. The occurrence of dysprosium on the outermost layer of dysprosium containing silica particles was investigated by XPS analysis. The MRI contrast agent characteristics have been tested using RARE-T1 and RARE-T2 protocols. The contrast of MRI images delivered by the investigated samples was correlated with their local structure. Dysprosium disposal on microparticles with surface structure characterised by decreased connectivity of the silicate network units favours dark T2-weighted MRI contrast properties.

  10. Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems

    Energy Technology Data Exchange (ETDEWEB)

    Arratia-Quijada, Jenny [Departamento de Ciencias de la Salud, Centro Universitario Tonalá, Universidad de Guadalajara, Av. Nuevo Periférico No. 555, C.P. 48525, Tonalá, Jalisco (Mexico); Sánchez Jiménez, Cecilia [Departamento de Química, Universidad de Guadalajara, Boulevard Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico); Gurinov, Andrey [Research Resources Center for Magnetic Resonance, St. Petersburg State University, Universitetskiy pr. 26, 198504 St. Petersburg (Russian Federation); NMR Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900 (Saudi Arabia); Pérez Centeno, Armando; Ceja Andrade, Israel [Departamento de Física, Universidad de Guadalajara, Boulevard Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico); Carbajal Arízaga, Gregorio Guadalupe, E-mail: gregoriocarbajal@yahoo.com.mx [Departamento de Química, Universidad de Guadalajara, Boulevard Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico)

    2016-01-15

    Graphical abstract: - Highlights: • LDH structure including dysprosium was prepared by co-precipitation. • LDH was capable to produce contrast in the T1 mode of MRI. • LDH were intercalated with folate, ibuprofen and gallate ions. - Abstract: A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nanoparticles showed a linear relationship with the reciprocal relaxation spin-lattice (T1) time of water protons which is reflected as contrast in aqueous suspensions analyzed by magnetic resonance imaging. The interlayer space of dysprosium containing LDH was successfully intercalated with folate, ibuprofen and gallate ions, which are key molecules for recognition of some cancer cells and treatment of diseases. The paramagnetic property of the dysprosium-containing LDH detected in this work beside the ability to transport drugs open up the opportunity to design theranostic materials in a single crystal phase with nanometric dimensions.

  11. Slow magnetic relaxation in a hydrogen-bonded 2D array of mononuclear dysprosium(III) oxamates.

    Science.gov (United States)

    Fortea-Pérez, Francisco R; Vallejo, Julia; Julve, Miguel; Lloret, Francesc; De Munno, Giovanni; Armentano, Donatella; Pardo, Emilio

    2013-05-01

    The reaction of N-(2,6-dimethylphenyl)oxamic acid with dysprosium(III) ions in a controlled basic media afforded the first example of a mononuclear lanthanide oxamate complex exhibiting a field-induced slow magnetic relaxation behavior typical of single-ion magnets (SIMs). The hydrogen-bond-mediated self-assembly of this new bifunctional dysprosium(III) SIM in the solid state provides a unique example of 2D hydrogen-bonded polymer with a herringbone net topology.

  12. Dysprosium-Catalyzed Growth of Single-Walled Carbon Nanotube Arrays on Substrates

    Directory of Open Access Journals (Sweden)

    Qian Yong

    2009-01-01

    Full Text Available Abstract In this letter, we report that dysprosium is an effective catalyst for single-walled carbon nanotubes (SWNTs growth via a chemical vapor deposition (CVD process for the first time. Horizontally superlong well-oriented SWNT arrays on SiO2/Si wafer can be fabricated by EtOH-CVD under suitable conditions. The structure and properties are characterized by scanning electron microscopy, transition electron microscopy, Raman spectroscopy and atomic force microscopy. The results show that the SWNTs from dysprosium have better structural uniformity and better conductivity with fewer defects. This rare earth metal provides not only an alternative catalyst for SWNTs growth, but also a possible method to generate high percentage of superlong semiconducting SWNT arrays for various applications of nanoelectronic device.

  13. Direct Search for keV Sterile Neutrino Dark Matter with a Stable Dysprosium Target

    CERN Document Server

    Lasserre, T; Cribier, M; Merle, A; Mertens, S; Vivier, M

    2016-01-01

    We investigate a new method to search for keV-scale sterile neutrinos that could account for Dark Matter. Neutrinos trapped in our galaxy could be captured on stable $^{163}$Dy if their mass is greater than 2.83~keV. Two experimental realizations are studied, an integral counting of $^{163}$Ho atoms in dysprosium-rich ores and a real-time measurement of the emerging electron spectrum in a dysprosium-based detector. The capture rates are compared to the solar neutrino and radioactive backgrounds. An integral counting experiment using several kilograms of $^{163}$Dy could reach a sensitivity for the sterile-to-active mixing angle $\\sin^2\\theta_{e4}$ of $10^{-5}$ significantly exceeding current laboratory limits. Mixing angles as low as $\\sin^2\\theta_{e4} \\sim 10^{-7}$ / $\\rm m_{^{163}\\rm Dy}\\rm{(ton)}$ could possibly be explored with a real-time experiment.

  14. Preparation of Dysprosium Ferrite/Polyacrylamide Magnetic Composite Microsphere and Its Characterization

    Institute of Scientific and Technical Information of China (English)

    Hidehiro Kumazawa; Wang Zhifeng; Zhou Lanxiang; Zhang Hong; Li Yourong; Zhang Ming

    2005-01-01

    Using the technique of microemulsion polymerization with nano-reactor, dysprosium ferrite/polyacrylamide magnetic composite microsphere was prepared by one-step method in a single inverse microemulsion. The structure, average particle size, morphology of composite microsphere were characterized by FTIR, XRD, TEM and TGA. The magnetic responsibility of composite microsphere was also investigated. The results indicate that the magnetic composite microsphere possess high magnetic responsibility and suspension stability.

  15. {Delta}I = 2 energy staggering in normal deformed dysprosium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Riley, M.A.; Brown, T.B.; Archer, D.E. [Florida State Univ., Tallahassee, FL (United States)] [and others

    1996-12-31

    Very high spin states (I{ge}50{Dirac_h}) have been observed in {sup 155,156,157}Dy. The long regular band sequences, free from sharp backbending effects, observed in these dysprosium nuclei offer the possibility of investigating the occurence of any {Delta}I = 2 staggering in normal deformed nuclei. Employing the same analysis techniques as used in superdeformed nuclei, certain bands do indeed demonstrate an apparent staggering and this is discussed.

  16. Poly[[[μ3-N′-(carboxymethylethylenediamine-N,N,N′-triacetato]dysprosium(III] trihydrate

    Directory of Open Access Journals (Sweden)

    Xiaomei Zhuang

    2010-11-01

    Full Text Available In the title coordination polymer, {[Dy(C10H13N2O8]·3H2O}n, the dysprosium(III ion is coordinated by two N atoms and six O atoms from three different (carboxymethylethylenediaminetriacetate ligands in a distorted square-antiprismatic geometry. The ligands connect the metal atoms, forming layers parallel to the ab plane. O—H...O hydrogen bonds further assemble adjacent layers into a three-dimensional supramolecular network.

  17. Making two dysprosium atoms rotate - Einstein-de Haas effect revisited

    OpenAIRE

    Górecki, Wojciech; Rzążewski, Kazimierz

    2016-01-01

    We present a numerical study of the behaviour of two magnetic dipolar atoms trapped in a harmonic potential and exhibiting the standard Einstein-de Haas effect while subject to a time dependent homogeneous magnetic field. Using a simplified description of the short range interaction and the full expression for the dipole-dipole forces we show, that under experimentally realisable conditions two dysprosium atoms may be pumped to a high ($l>20$) value of the relative orbital angular momentum.

  18. Phosphor Dysprosium-Doped Layered Double Hydroxides Exchanged with Different Organic Functional Groups

    Directory of Open Access Journals (Sweden)

    David Ricardo Martínez Vargas

    2013-01-01

    Full Text Available The layers of a Zn/Al layered double hydroxide (LDH were doped with Dy3+ cations. Among some compositions, the Zn2+ : Al3+ : Dy3+ molar ratio equal to 30 : 9 : 1 presented a single crystalline phase. Organic anions with carboxylic, amino, sulfate, or phosphate functional groups were intercalated as single layers between LDH layers as confirmed by X-ray diffraction and infrared spectroscopy. Photoluminescence spectra of the nitrate intercalated LDH showed a wide emission band with strong intensity in the yellow region (around 574 nm, originated due to symmetry distortion of the octahedral coordination in dysprosium centers. Moreover, a broad red band emission was also detected apparently due to the presence of zinc oxide. The distorted symmetry of the dysprosium coordination environment, also confirmed by X-ray photoelectron spectroscopy analysis, was modified after the intercalation with phenyl phosphonate (PP, aspartate (Asp, adipate (Adip, and serinate (Ser anions; the emission as measured from PL spectra of these LDH was more intense in the blue region (ca. 486 nm, thus indicating an increase in symmetry of dysprosium octahedrons. The red emission band from zinc oxide kept the same intensity after intercalation of dodecyl sulfate (DDS. An additional emission of unknown origin at λ = 767 nm was present in all LDHs.

  19. Systematic study on surface and magnetostructural changes in Mn-substituted dysprosium ferrite by hydrothermal method

    Energy Technology Data Exchange (ETDEWEB)

    Rekha, G. [Department of Physics, College of Engineering Guindy, Anna University, Sardar Patel Road, Chennai 600025 (India); Tholkappiyan, R. [Department of Physics, College of Engineering Guindy, Anna University, Sardar Patel Road, Chennai 600025 (India); Department of Physics, College of Science, UAE University, Al-Ain 15551 (United Arab Emirates); Vishista, K., E-mail: raovishista@gmail.com [Department of Physics, College of Engineering Guindy, Anna University, Sardar Patel Road, Chennai 600025 (India); Hamed, Fathalla [Department of Physics, College of Science, UAE University, Al-Ain 15551 (United Arab Emirates)

    2016-11-01

    Highlights: • Garnet type Dy{sub 3}Fe{sub 5-x}Mn{sub x}O{sub 12} (x = 0–0.06) nanoparticles of 88.4–86.8 nm were synthesized by hydrothermal method. • The Dy, Mn, Fe and O elements in the ferrites were confirmed from XPS. • The multiple oxidation states of Fe and Mn ions, bonding energy and cationic distributions of the samples were examined by XPS. • The magnetic property shows ferromagnetic behavior from VSM technique. • The results from these studies are correlated with respect to Mn dopant. - Abstract: Dysprosium iron garnets are of scientific importance because of the wide range of magnetic properties that can be obtained in substituting dysprosium by a rare earth metal. In the present work, the effect of Mn substitution on magnetostructural changes in dysprosium ferrite nanoparticles is studied. Highly crystalline pure and Mn doped dysprosium ferrite nanoparticles were synthesized by hydrothermal method. The samples were calcined at 1100 °C for 2 h in air atmosphere which is followed by characterization using XRD, FT-IR analysis, SEM, XPS and VSM. The average crystallite size of synthesized samples were calculated by X-ray diffraction falls in the range of 88.4–86.8 nm and was found to be in cubic garnet structure. For further investigation of the structure and corresponding changes in the tetrahedral and octahedral stretching vibrational bonds, FT-IR was used. The synthesized samples consist of multiple oxidation (Fe{sup 3+} and Fe{sup 2+}) states for Fe ions and (Mn{sup 3+} and Mn{sup 2+}) Mn ions analyzed in three ways of Fe 2p and Mn 2p spectra from the XPS analysis. With respect to Mn dopant in Dy{sub 3}Fe{sub 5}O{sub 12}, the cationic distributions of elements were discussed from high resolution XPS spectra by peak position and shift, area, width. To find out the porous/void surface morphology of the sample, scanning electron microscopy was used. From XPS analysis, the presence of elements (Dy, Mn, Fe and O) and their composition in the

  20. Synthesis, structural characterization and in vitro testing of dysprosium containing silica particles as potential MRI contrast enhancing agents

    Energy Technology Data Exchange (ETDEWEB)

    Chiriac, L.B.; Trandafir, D.L. [Faculty of Physics & National Magnetic Resonance Center, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Interdisciplinary Research Institute on Bio-Nano-Sciences & Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Turcu, R.V.F. [Faculty of Physics & National Magnetic Resonance Center, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Todea, M. [Interdisciplinary Research Institute on Bio-Nano-Sciences & Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Simon, S., E-mail: simons@phys.ubbcluj.ro [Faculty of Physics & National Magnetic Resonance Center, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Interdisciplinary Research Institute on Bio-Nano-Sciences & Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania)

    2016-11-01

    Highlights: • Dysprosium containing silica microparticles obtained by freeze and spray drying. • Higher structural units interconnection achieved in freeze vs. spray dried samples. • Dy occurance on the outermost layer of the microparticles evidenced by XPS. • Enhanced MRI contrast observed for freeze dried samples with 5% mol Dy{sub 2}O{sub 3}. - Abstract: The work is focused on synthesis and structural characterization of novel dysprosium-doped silica particles which could be considered as MRI contrast agents. Sol-gel derived silica rich particles obtained via freeze-drying and spray-drying processing methods were structurally characterized by XRD, {sup 29}Si MAS-NMR and XPS methods. The occurrence of dysprosium on the outermost layer of dysprosium containing silica particles was investigated by XPS analysis. The MRI contrast agent characteristics have been tested using RARE-T{sub 1} and RARE-T{sub 2} protocols. The contrast of MRI images delivered by the investigated samples was correlated with their local structure. Dysprosium disposal on microparticles with surface structure characterised by decreased connectivity of the silicate network units favours dark T{sub 2}-weighted MRI contrast properties.

  1. Influence of exchange splitting on optical properties in gadolinium and dysprosium single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Knyazev, Yu.V.; Bolotin, G.A. (AN SSSR, Sverdlovsk. Inst. Fiziki Metallov)

    1984-12-01

    The temperature dependences of optical conductivity in gadolinium and dysprosium single crystals at the light wave vector polarization along a hexagonal axis and in the basis plane are considered. A substantial anisotropy of interzonal absorption has been found. The sample transition into magnetically ordered state is shown to be accompanied by the emergence of resonance absorption peaks in the near infrared spectral region. The manifestation of these peculiarities is associated with quantum electron transitions between the s-, d-f- interaction-split energy bands near the Fermi level. Main peculiarities of the experimental spectrum of gadolinium optical conductivity found their reflection in theoretically calculated dispersion dependence.

  2. Therapeutic application of dysprosium-165-FHMA in the treatment of rheumatoid knee effusions

    Energy Technology Data Exchange (ETDEWEB)

    English, R.J.; Zalutsky, M.; Venkatesan, P.; Sledge, C.B.

    1986-03-01

    Radiation synovectomy utilizing a variety of radionuclides has proven to be an effective technique in the treatment of rheumatoid arthritis. The recent introduction of the short-lived radionuclide, Dysprosium-165 (/sup 165/Dy), as a replacement for the longer-lived radiocolloids has reduced nontarget dosimetry caused by leakage of the agent from the articular cavity. A review of the methods and status of radiation synovectomy, and the application of /sup 165/Dy-ferric hydroxide macroaggregates (FHMA) as an alternative therapeutic agent is described.

  3. Properties of dysprosium-doped gallium lanthanum sulfide fiber amplifiers operating at 1.3 microm.

    Science.gov (United States)

    Samson, B N; Schweizer, T; Hewak, D W; Laming, R I

    1997-05-15

    In light of recent progress in the fabrication of gallium lanthanum sulfide (GaLaS) fibers, we have modeled the performance of dysprosium-doped GaLaS fiber amplifiers operating at 1.3 microm . Based on experimental data, we find that the incorporation of a codopant (terbium) in the fiber core significantly shortens the optimum amplifier length from >30 m to approximately 3 m . Such a device may be practical, given the fiber losses currently achieved in GaLaS fibers.

  4. Effect of dysprosium on the kinetics and structural transformations during the decomposition of the supersaturated solid solution in magnesium-samarium alloys

    Science.gov (United States)

    Rokhlin, L. L.; Luk'yanova, E. A.; Tabachkova, N. Yu.; Dobatkina, T. V.; Tarytina, I. E.; Korol'kova, I. G.

    2017-03-01

    The effect of dysprosium added in the amounts such that it does not form an individual phase in equilibrium with solid magnesium on the decomposition of the supersaturated magnesium solid solution in Mg-Sm alloys is studied. The presence of dysprosium in Mg-Sm alloys is found to retard the decomposition of the supersaturated magnesium solid solution and to increase the hardening effect upon aging. When these alloys are aged, dysprosium is partly retained in the magnesium solid solution and partly enters into the compositions of the phases that form during the decomposition of the solid solution and are characteristic of Mg-Sm alloys.

  5. Cyclic single-molecule magnets: from the odd-numbered heptanuclear to a dimer of heptanuclear dysprosium clusters.

    Science.gov (United States)

    Tian, Haiquan; Bao, Song-Song; Zheng, Li-Min

    2016-02-01

    A heptanuclear and a dimer of heptanuclear dysprosium clusters (Dy7 and Dy14) have been successfully synthesized by ingenious coalescence of the single and double pyrazinyl hydrazone as well as phosphonate ligands. The complexes feature the largest odd-numbered cyclic lanthanide clusters reported thus far. Both exhibit single molecule magnet behaviors at low temperature.

  6. A comparison of the effects of symmetry and magnetoanisotropy on paramagnetic relaxation in related dysprosium single ion magnets.

    Science.gov (United States)

    Williams, Ursula J; Mahoney, Brian D; DeGregorio, Patrick T; Carroll, Patrick J; Nakamaru-Ogiso, Eiko; Kikkawa, James M; Schelter, Eric J

    2012-06-07

    Dysprosium complexes of the tmtaa(2-) ligand were synthesized and characterized by X-band EPR and magnetism studies. Both complexes demonstrate magnetoanisotropy and slow paramagnetic relaxation. Comparison of these compounds with the seminal phthalocyanine complex [Dy(Pc)(2)](-) shows the azaannulide complexes are more susceptible to relaxation through non-thermal pathways.

  7. Dual responsive dysprosium-doped hydroxyapatite particles and toxicity reduction after functionalization with folic and glucuronic acids

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez Lafarga, Ana Karen; Pacheco Moisés, Fermín P. [Departamento de Química, Universidad de Guadalajara, Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico); Gurinov, Andrey [Research Resources Center for Magnetic Resonance, Saint Petersburg State University, Universitetskij pr. 26, 198504 St. Petersburg (Russian Federation); Ortiz, Genaro Gabriel [Laboratorio Desarrollo-Envejecimiento, Enfermedades Neurodegenerativas, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano de Seguro Social (IMSS), Guadalajara, Jalisco (Mexico); Carbajal Arízaga, Gregorio Guadalupe, E-mail: gregoriocarbajal@yahoo.com.mx [Departamento de Química, Universidad de Guadalajara, Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico)

    2015-03-01

    The development of probes for biomedical applications demands materials with low toxicity levels besides fluorescence or magnetic properties to be detected by confocal microscopes or MRI resonators. Several drug delivery systems or other biomedical materials prepared with hydroxyapatite have been proposed, however, toxicity effects might arise when the size of particles is nanometric. In this study, hydroxyapatite functionalized with glucuronic or folic acids presented lower oxidative stress, measured from lipoperoxides and nitric oxide indicators in rats than pure hydroxyapatite. In separated experiments, hydroxyapatite was doped with dysprosium cations by coprecipitation producing a single crystal phase with fluorescent properties easily visualized by confocal microscopy when excited at 488 nm. These particles also presented the ability to modify the proton relaxation time in T1 maps collected by magnetic resonance imaging. These modified hydroxyapatite nanoparticles could be candidates to design bimodal probes with low toxicity. - Highlights: • Hydroxyapatite functionalized with glucuronic acid reduced oxidative stress in rats. • Functionalization with folic acid reduced oxidative stress in rats. • Dysprosium doping does not affect the crystalline structure of hydroxyapatite. • Dysprosium doped particles are visible in fluorescent microscope. • Dysprosium doped particles act as MRI contrast agents.

  8. Tuning Slow Magnetic Relaxation in a Two-Dimensional Dysprosium Layer Compound through Guest Molecules.

    Science.gov (United States)

    Chen, Qi; Li, Jian; Meng, Yin-Shan; Sun, Hao-Ling; Zhang, Yi-Quan; Sun, Jun-Liang; Gao, Song

    2016-08-15

    A novel two-dimensional dysprosium(III) complex, [Dy(L)(CH3COO)]·0.5DMF·H2O·2CH3OH (1), has been successfully synthesized from a new pyridine-N-oxide (PNO)-containing ligand, namely, N'-(2-hydroxy-3-methoxybenzylidene)pyridine-N-oxidecarbohydrazide (H2L). Single-crystal X-ray diffraction studies reveal that complex 1 is composed of a dinuclear dysprosium subunit, which is further extended by the PNO part of the ligand to form a two-dimensional layer. Magnetic studies indicate that complex 1 shows well-defined temperature- and frequency-dependent signals under a zero direct-current (dc) field, typical of slow magnetic relaxation with an effective energy barrier Ueff of 33.6 K under a zero dc field. Interestingly, powder X-ray diffraction and thermogravimetric analysis reveal that compound 1 undergoes a reversible phase transition that is induced by the desorption and absorption of methanol and water molecules. Moreover, the desolvated sample [Dy(L)(CH3COO)]·0.5DMF (1a) also exhibits slow magnetic relaxation but with a higher anisotropic barrier of 42.0 K, indicating the tuning effect of solvent molecules on slow magnetic relaxation.

  9. Dosimetric properties of dysprosium doped calcium magnesium borate glass subjected to Co-60 gamma ray

    Energy Technology Data Exchange (ETDEWEB)

    Omar, R. S., E-mail: ratnasuffhiyanni@gmail.com; Wagiran, H., E-mail: husin@utm.my; Saeed, M. A. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru (Malaysia)

    2016-01-22

    Thermoluminescence (TL) dosimetric properties of dysprosium doped calcium magnesium borate (CMB:Dy) glass are presented. This study is deemed to understand the application of calcium as the modifier in magnesium borate glass with the presence of dysprosium as the activator to be performed as TL dosimeter (TLD). The study provides fundamental knowledge of a glass system that may lead to perform new TL glass dosimetry application in future research. Calcium magnesium borate glass systems of (70-y) B{sub 2}O{sub 3} − 20 CaO – 10 MgO-(y) Dy{sub 2}O{sub 3} with 0.05  mol % ≤ y ≤ 0.7  mol % of dyprosium were prepared by melt-quenching technique. The amorphous structure and TL properties of the prepared samples were determined using powder X-ray diffraction (XRD) and TL reader; model Harshaw 4500 respectively. The samples were irradiated to Co-60 gamma source at a dose of 50 Gy. Dosimetric properties such as annealing procedure, time temperature profile (TTP) setting, optimization of Dy{sub 2}O{sub 3} concentration of 0.5 mol % were determined for thermoluminescence dosimeter (TLD) reader used.

  10. 20 CFR 401.140 - General principles.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false General principles. 401.140 Section 401.140... INFORMATION Disclosure of Official Records and Information § 401.140 General principles. When no law... follow FOIA principles to resolve that question. We do this to insure uniform treatment in all...

  11. 21 CFR 820.140 - Handling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Handling. 820.140 Section 820.140 Food and Drugs... QUALITY SYSTEM REGULATION Handling, Storage, Distribution, and Installation § 820.140 Handling. Each..., contamination, or other adverse effects to product do not occur during handling. ...

  12. 12 CFR 308.140 - Newspaper notice.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Newspaper notice. 308.140 Section 308.140 Banks... Securities Exchange Act of 1934 § 308.140 Newspaper notice. (a) General rule. If the Board of Directors or... shall be served upon the applicant instructions to publish one notification in a newspaper of general...

  13. 23 CFR 140.612 - Cash management.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Cash management. 140.612 Section 140.612 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.612 Cash management. By July 1 of each year the SHA will...

  14. 23 CFR 140.912 - Transportation.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Transportation. 140.912 Section 140.912 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Railroad Work § 140.912 Transportation. (a) Employees. The company's cost of necessary...

  15. 25 CFR 140.21 - Gambling.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Gambling. 140.21 Section 140.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LICENSED INDIAN TRADERS § 140.21 Gambling. Gambling, by dice, cards, or in any way whatever, is strictly prohibited in any licensed trader's store...

  16. 21 CFR 169.140 - Mayonnaise.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Mayonnaise. 169.140 Section 169.140 Food and Drugs... § 169.140 Mayonnaise. (a) Description. Mayonnaise is the emulsified semisolid food prepared from... section. All the ingredients from which the food is fabricated shall be safe and suitable. Mayonnaise...

  17. 42 CFR 417.140 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 417.140 Section 417.140 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Application for Federal Qualification § 417.140 Scope. This subpart sets forth— (a) The requirements for—...

  18. 23 CFR 140.606 - Project agreements.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Project agreements. 140.606 Section 140.606 Highways... Reimbursement for Bond Issue Projects § 140.606 Project agreements. Project Agreements, Form PR-2, shall be prepared and executed. Agreement provision 8 on the reverse side of Form PR-2 1 shall apply for bond issue...

  19. 21 CFR 606.140 - Laboratory controls.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Laboratory controls. 606.140 Section 606.140 Food... CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Laboratory Controls § 606.140 Laboratory controls. Laboratory control procedures shall include: (a) The establishment of...

  20. 40 CFR 1033.140 - Rated power.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Rated power. 1033.140 Section 1033.140... EMISSIONS FROM LOCOMOTIVES Emission Standards and Related Requirements § 1033.140 Rated power. This section describes how to determine the rated power of a locomotive for the purposes of this part. (a) A...

  1. 42 CFR 1004.140 - Appeal rights.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Appeal rights. 1004.140 Section 1004.140 Public... IMPROVEMENT ORGANIZATION Appeals § 1004.140 Appeal rights. (a) Right to preliminary hearing. (1)(i) A... its right to a preliminary hearing, such a hearing must be held by the ALJ in accordance...

  2. 23 CFR 140.607 - Construction.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Construction. 140.607 Section 140.607 Highways FEDERAL... Bond Issue Projects § 140.607 Construction. Construction shall be supervised by the SHA in the same manner as for regularly financed Federal-aid projects. The FHWA will make construction inspections...

  3. Luminescent properties of dysprosium(Ⅲ) ions in LaAlO3 nanocrystallites

    Institute of Scientific and Technical Information of China (English)

    K. Lema(n)ski; P.J. Dere(n)

    2011-01-01

    The absorption and emission spectra as well as decay time profile of Dy3+ ions in LaAlO3 nanocrystals were analyzed.The crystal structure of LaAlO3 was confirmed from XRD measurement.The emission peaks from blue to red came from main emitting level of dysprosium 4F9/2 to the ground and other excited levels of Dy3+ ions.Cross relaxation process led to non-radiative quenching of luminescence,so that the lifetime of the 4F9/2 energy level ions decreased with increasing amount of doped Dy3+ ions.The cross relaxation transfer rates were experimentally determined as a function of Dy3+ concentration.

  4. Magnetic ordering temperatures in rare earth metal dysprosium under ultrahigh pressures

    Science.gov (United States)

    Samudrala, Gopi K.; Tsoi, Georgiy M.; Weir, Samuel T.; Vohra, Yogesh K.

    2014-04-01

    Magnetic ordering temperatures in heavy rare earth metal dysprosium (Dy) have been studied using an ultrasensitive electrical transport measurement technique in a designer diamond anvil cell to a pressure of 69 GPa and a temperature of 10 K. Previous studies using magnetic susceptibility measurements at high pressures were able to track magnetic ordering temperature only till 7 GPa in the hexagonal close packed (hcp) phase of Dy. Our studies indicate that the magnetic ordering temperature shows an abrupt drop of 80 K at the hcp-Sm phase transition followed by a gradual decrease that continues till 17 GPa. This is followed by a rapid increase in the magnetic ordering temperatures in the double hcp phase and finally leveling off in the distorted face centered cubic phase of Dy. Our studies reaffirm that 4f-shell remains localized in Dy and there is no loss of magnetic moment or 4f-shell delocalization for pressures up to 69 GPa.

  5. Electrochemical behaviour of dysprosium in the eutectic LiCl-KCl at W and Al electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Castrillejo, Y. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain)]. E-mail: ycastril@qa.uva.es; Bermejo, M.R. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Barrado, A.I. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Pardo, R. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Barrado, E. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Martinez, A.M. [Department of Materials Technology, Sem Saelands vei 6, 7491 Trondheim (Norway)

    2005-03-15

    The electrochemical behaviour of DyCl{sub 3} was studied in the eutectic LiCl-KCl at different temperatures. The cathodic reaction can be written:Dy(III)+3e-bar Dy(0)which can be divided in two very close cathodic steps:Dy(III)+1e-bar Dy(II)andDy(II)+2e-bar Dy(0)Transient electrochemical techniques, such as cyclic voltammetry, chronopotentiometry, and chronoamperometry were used in order to study the reaction mechanism and the transport parameters of electroactive species at a tungsten electrode. The results showed that in the eutectic LiCl-KCl, electrocrystallization of dysprosium seems to be the controlling electrochemical step. Chronoamperometric studies indicated instantaneous nucleation of dysprosium with three dimensional growth of the nuclei whatever the applied overpotential.Mass transport towards the electrode is a simple diffusion process, and the diffusion coefficient of the electroactive species, i.e. Dy(III), has been calculated. The validity of the Arrhenius law was also verified by plotting the variation of the logarithm of the diffusion coefficient versus 1/T.In addition, the electrode reactions of the LiCl-KCl-DyCl{sub 3} solutions at an Al wire were also investigated by cyclic voltammetry and open circuit chronopotentiometry. The redox potential of the Dy(III)/Dy couple at the Al electrode was observed at more positive potentials values than those at the inert electrode. This potential shift was thermodynamically analyzed by a lowering of activity of Dy in the metal phase due to the formation of intermetallic compounds.

  6. Structural, optical, thermal, mechanical and dielectric studies of Sulfamic acid single crystals: An influence of dysprosium (Dy3+) doping

    Science.gov (United States)

    Singh, Budhendra; Shkir, Mohd.; AlFaify, S.; Kaushal, Ajay; Nasani, Narendar; Bdikin, Igor; Shoukry, H.; Yahia, I. S.; Algarni, H.

    2016-09-01

    Sulfamic acid is a potential material that exhibits excellent optical properties. A good quality, pure and dysprosium (Dy3+) doped (2.5 and 5 mol %) Sulfamic acid (SA) single crystals were grown successfully by slow cooling method. Structural study revealed a slight change in its lattice parameters and volume, suggesting the successful incorporation of Dy3+ in crystal system. The existence of dysprosium in the system was also confirmed. Presence of various vibrational modes was confirmed. Optical transparency was found to have a significant effect with variation in the doping concentration. Furthermore, a marked enhancement in its mechanical parameters with doping was also identified by nanoindentation technique. Etching study was also performed on the grown crystals to study the etch-pit formation and growth mechanism. Effect of doping on the thermal stability was analysed. All the results were compared and discussed in detail to get insight of the effect of doping concentration on Sulfamic acid crystal.

  7. Optical trapping of ultracold dysprosium atoms: transition probabilities, dynamic dipole polarizabilities and van der Waals $C_6$ coefficients

    CERN Document Server

    Li, Hui; Dulieu, Olivier; Nascimbene, Sylvain; Lepers, Maxence

    2016-01-01

    The efficiency of optical trapping of ultracold atoms depend on the atomic dynamic dipole polarizability governing the atom-field interaction. In this article, we have calculated the real and imaginary parts of the dynamic dipole polarizability of dysprosium in the ground and first excited level. Due to the high electronic angular momentum of those two states, the polarizabilities possess scalar, vector and tensor contributions that we have computed, on a wide range of trapping wavelengths, using the sum-over-state formula. Using the same formalism, we have also calculated the $C_6$ coefficients characterizing the van der Waals interaction between two dysprosium atoms in the two lowest levels. We have computed the energies of excited states and the transition probabilities appearing in the sums, using a combination of \\textit{ab initio} and least-square-fitting techniques provided by the Cowan codes and extended in our group. Regarding the real part of the polarizability, for field frequencies far from atomic...

  8. 40 CFR 35.140 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.140 Purpose. (a) Purpose of section. Sections 35.140 through 35.148 govern Air Pollution Control Grants to State, local, interstate, or intermunicipal air pollution control agencies (as defined in section 302(b) of the Clean Air...

  9. 27 CFR 9.140 - Atlas Peak.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Atlas Peak. 9.140 Section... THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.140 Atlas Peak. (a) Name. The name of the viticultural area described in this section is “Atlas Peak.”...

  10. 17 CFR 140.1 - Headquarters office.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Headquarters office. 140.1..., FUNCTIONS, AND PROCEDURES OF THE COMMISSION Organization § 140.1 Headquarters office. (a) General. The headquarters office of the Commission is located at Three Lafayette Centre, 1155 21st Street, NW.,...

  11. 25 CFR 140.26 - Infectious plants.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Infectious plants. 140.26 Section 140.26 Indians BUREAU... Infectious plants. Traders shall not introduce into, sell, or spread within Indian reservations any plant, plant product, seed, or any type of vegetation, which is infested, or infected or which might act as...

  12. 33 CFR 140.30 - Judicial review.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Judicial review. 140.30 Section... CONTINENTAL SHELF ACTIVITIES GENERAL General § 140.30 Judicial review. (a) Nothing in this subchapter shall be construed to prevent any interested party from seeking judicial review as authorized by law. (b)...

  13. 40 CFR 140.5 - Analytical procedures.

    Science.gov (United States)

    2010-07-01

    ...) MARINE SANITATION DEVICE STANDARD § 140.5 Analytical procedures. In determining the composition and quality of effluent discharge from marine sanitation devices, the procedures contained in 40 CFR part 136... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Analytical procedures. 140.5...

  14. 24 CFR 100.140 - General rules.

    Science.gov (United States)

    2010-04-01

    ... DISCRIMINATORY CONDUCT UNDER THE FAIR HOUSING ACT Discrimination in Residential Real Estate-Related Transactions... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false General rules. 100.140 Section 100.140 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE...

  15. 21 CFR 172.140 - Ethoxyquin.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Ethoxyquin. 172.140 Section 172.140 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION...

  16. Mixed (phthalocyaninato)(Schiff-base) di-dysprosium sandwich complexes. Effect of magnetic coupling on the SMM behavior.

    Science.gov (United States)

    Wang, Hailong; Liu, Chenxi; Liu, Tao; Zeng, Suyuan; Cao, Wei; Ma, Qi; Duan, Chunying; Dou, Jianmin; Jiang, Jianzhuang

    2013-11-21

    Reaction between Schiff-base ligand and half-sandwich complex M(Pc)(acac) led to the isolation of new sandwich-type mixed (phthalocyaninato)(Schiff-base) di-lanthanide compounds M2(Pc)2(L)H2O (M = Dy, Gd) (1, 2) [H2Pc = metal free phthalocyanine, Hacac = acetylacetone, H2L = N,N'-bis(3-methyloxysalicylidene)benzene-1,2-diamine] with the triple-decker molecular structure clearly revealed by single crystal X-ray diffraction analysis. For the comparative studies, sandwich triple-decker analogues with pure Schiff-base ligand M2(L)3H2O (M = Dy, Gd) (3, 4) were also prepared. Dynamic magnetic measurement result reveals the single-molecule magnet (SMM) nature of the di-dysprosium derivative 1, while the static magnetic investigation over both pure and the diamagnetic diluted samples of this compound discloses the interionic ferromagnetic coupling between the two dysprosium ions, which in turn effectively suppresses the QTM and enhances the energy barrier of this SMM. Nevertheless, comparative studies over the static magnetic properties of the di-dysprosium triple-decker complexes 1 and 3 indicate the stronger magnetic coupling between the two lanthanide ions in mixed (phthalocyaninato)(Schiff-base) species than in the pure Schiff-base triple-decker analogue, suggesting the special coordination sphere around the dysprosium ions in the former compound over the latter one on the more intense inter-ionic ferromagnetic coupling. As a very small step towards understanding the structure-property relationship, the present result will be surely helpful for the design and synthesis of the multinuclear lanthanide-based SMMs with good properties.

  17. Dicty_cDB: SLA140 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA140 (Link to dictyBase) - - - Contig-U16285-1 SLA140Z (Link... to Original site) - - SLA140Z 636 - - - - Show SLA140 Library SL (Link to library) Clone ID SLA140 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLA1-B/SLA140Q.Seq.d/ Representative seq. ID SLA14...0Z (Link to Original site) Representative DNA sequence >SLA140 (SLA140Q) /CSM/SL/SLA1-B/SLA140Q.Seq.d/ XXXXX...AACTAAAAAC AATAAATAAAATTTTATTAAATTTTTAATTTTATTTTTTTATATAA sequence update 1997. 5. 8 Translated Amino Acid s

  18. Evaluating United States and world consumption of neodymium, dysprosium, terbium, and praseodymium in final products

    Science.gov (United States)

    Hart, Matthew

    This paper develops scenarios of future rare-earth-magnet metal (neodymium, dysprosium, terbium, and praseodymium) consumption in the permanent magnets used in wind turbines and hybrid electric vehicles. The scenarios start with naive base-case scenarios for growth in wind-turbine and hybrid-electric-vehicle sales over the period 2011 to 2020, using historical data for each good. These naive scenarios assume that future growth follows time trends in historical data and does not depend on any exogenous variable. Specifically, growth of each technological market follows historical time trends, and the amount of rare earths used per unit of technology remains fixed. The chosen reference year is 2010. Implied consumptions of the rare earth magnet metals are calculated from these scenarios. Assumptions are made for the material composition of permanent magnets, the market share of permanent-magnet wind turbines and vehicles, and magnet weight per unit of technology. Different scenarios estimate how changes in factors like the material composition of magnets, growth of the economy, and the price of a substitute could affect future consumption. Each scenario presents a different method for reducing rare earth consumption and could be interpreted as potential policy choices. In 2010, the consumption (metric tons, rare-earth-oxide equivalent) of each rare-earth-magnet metal was as follows. Total neodymium consumption in the world for both technologies was 995 tons; dysprosium consumption was 133 tons; terbium consumption was 50 tons; praseodymium consumption was zero tons. The base scenario for wind turbines shows there could be strong, exponential growth in the global wind turbine market. New U.S. sales of hybrid vehicles would decline (in line with the current economic recession) while non-U.S. sales increase through 2020. There would be an overall increase in the total amount of magnetic rare earths consumed in the world. Total consumption of each rare earth in the short

  19. 29 CFR 500.140 - General.

    Science.gov (United States)

    2010-07-01

    ... Act, discriminates against any migrant or seasonal agricultural worker. ... to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Enforcement § 500.140 General. Whenever the Secretary believes that the Act...

  20. Dicty_cDB: CHS140 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS140 (Link to dictyBase) - - - Contig-U16405-1 CHS140P (Link to Original site) CHS1...40F 553 CHS140Z 718 CHS140P 1251 - - Show CHS140 Library CH (Link to library) Clone ID CHS1...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHS1-B/CHS140Q.Seq.d/ Representative seq. ID CHS1...40P (Link to Original site) Representative DNA sequence >CHS140 (CHS140Q) /CSM/CH/CHS1-B/CHS1...ucing significant alignments: (bits) Value CHS140 (CHS140Q) /CSM/CH/CHS1-B/CHS140Q.Seq.d/ 1392 0.0 AHK465 (A

  1. Luminescence features of dysprosium and phosphorus oxide co-doped lithium magnesium borate glass

    Science.gov (United States)

    Hashim, S.; Mhareb, M. H. A.; Ghoshal, S. K.; Alajerami, Y. S. M.; Saripan, M. I.; Bradley, D. A.

    2017-08-01

    Lithium magnesium borate (LMB) glass system co-doped with the oxides of dysprosium (Dy2O3) and phosphorus (P2O5) were synthesized using melt-quenching method. Prepared samples were characterized using various techniques to determine the effects of co-dopants concentration variation on their thermoluminescence (TL) and photoluminescence (PL) properties. TL glow curves of LMB:0.5Dy sample revealed a single prominent peak at Tm=190 °C, where TL intensity was enhanced by a factor of 2.5 with the increase of P2O5 concentration up to 1 mol%. This enhancement was accompanied by a shift in Tm towards higher temperature. Good linearity in the range of 1-100 Gy with linear correlation coefficient of 0.998 was achieved. PL spectra displayed two significant peaks centred at 481 nm and 573 nm. These attractive luminescence features of the proposed glass system may be useful for the development of radiation dosimetry.

  2. Single-molecule magnet behavior for an antiferromagnetically superexchange-coupled dinuclear dysprosium(III) complex.

    Science.gov (United States)

    Long, Jérôme; Habib, Fatemah; Lin, Po-Heng; Korobkov, Ilia; Enright, Gary; Ungur, Liviu; Wernsdorfer, Wolfgang; Chibotaru, Liviu F; Murugesu, Muralee

    2011-04-13

    A family of five dinuclear lanthanide complexes has been synthesized with general formula [Ln(III)(2)(valdien)(2)(NO(3))(2)] where (H(2)valdien = N1,N3-bis(3-methoxysalicylidene)diethylenetriamine) and Ln(III) = Eu(III)1, Gd(III)2, Tb(III)3, Dy(III)4, and Ho(III)5. The magnetic investigations reveal that 4 exhibits single-molecule magnet (SMM) behavior with an anisotropic barrier U(eff) = 76 K. The step-like features in the hysteresis loops observed for 4 reveal an antiferromagnetic exchange coupling between the two dysprosium ions. Ab initio calculations confirm the weak antiferromagnetic interaction with an exchange constant J(Dy-Dy) = -0.21 cm(-1). The observed steps in the hysteresis loops correspond to a weakly coupled system similar to exchange-biased SMMs. The Dy(2) complex is an ideal candidate for the elucidation of slow relaxation of the magnetization mechanism seen in lanthanide systems.

  3. A comparative study of donor formation in dysprosium, holmium, and erbium implanted silicon

    Energy Technology Data Exchange (ETDEWEB)

    Emtsev, V.V.; Emtsev, V.V. Jr.; Poloskin, D.S.; Shek, E.I.; Sobolev, N.A. [Division of Solid State Electronics, Ioffe Physicotechnical Institute, Russian Academy of Sciences, 194021 St. Petersburg (Russian Federation)

    1998-12-01

    Formation of donor centers in Czochralski grown silicon doped with dysprosium, holmium, and erbium is discussed. Donor states of three kinds are introduced in the implanted layers after annealing at T=700C. Shallow donor states with ionization energies between 20 and 40 meV are attributed to oxygen -related thermal donors. Other donor centers in the energy range of E{sub C}-(60...70) meV and E{sub C}-(100...120) meV appear to be dependent on dopants. After a 900C anneal strong changes in the donor formation are observed only in silicon doped with erbium. Instead of donors at E{sub C}-(118{+-}5) meV, new donor centres at E{sub C}-(145{+-}5) meV are formed. Reportedly, the latter ones are involved in the excitation process of the Er{sup 3+} ions with a characteristic luminescence line at {approx}1.54 {mu}m. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  4. Thermoluminescence properties of lithium magnesium borate glasses system doped with dysprosium oxide.

    Science.gov (United States)

    Mhareb, M H A; Hashim, S; Ghoshal, S K; Alajerami, Y S M; Saleh, M A; Razak, N A B; Azizan, S A B

    2015-12-01

    We report the impact of dysprosium (Dy(3+)) dopant and magnesium oxide (MgO) modifier on the thermoluminescent properties of lithium borate (LB) glass via two procedures. The thermoluminescence (TL) glow curves reveal a single prominent peak at 190 °C for 0.5 mol% of Dy(3+). An increase in MgO contents by 10 mol% enhances the TL intensity by a factor of 1.5 times without causing any shift in the maximum temperature. This enhancement is attributed to the occurrence of extra electron traps created via magnesium and the energy transfer to trivalent Dy(3+) ions. Good linearity in the range of 0.01-4 Gy with a linear correlation coefficient of 0.998, fading as low as 21% over a period of 3 months, excellent reproducibility without oven annealing and tissue equivalent effective atomic numbers ~8.71 are achieved. The trap parameters, including geometric factor (μg), activation energy (E) and frequency factor (s) associated with LMB:Dy are also determined. These favorable TL characteristics of prepared glasses may contribute towards the development of Li2O-MgO-B2O3 radiation dosimeters.

  5. Optical properties of zinc borotellurite glass doped with trivalent dysprosium ion

    Science.gov (United States)

    Ami Hazlin, M. N.; Halimah, M. K.; Muhammad, F. D.; Faznny, M. F.

    2017-04-01

    The zinc borotellurite doped with dysprosium oxide glass samples with chemical formula {[(TeO2) 0 . 7(B2O3) 0 . 3 ] 0 . 7(ZnO) 0 . 3 } 1 - x(Dy2O3)x (where x=0.01, 0.02, 0.03, 0.04 and 0.05 M fraction) were prepared by using conventional melt quenching technique. The structural and optical properties of the proposed glass systems were characterized by using X-ray diffraction (XRD) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, and UV-VIS spectroscopy. The amorphous nature of the glass systems is confirmed by using XRD technique. The infrared spectra of the glass systems indicate three obvious absorption bands which are assigned to BO3 and TeO4 vibrational groups. Based on the absorption spectra obtained, the direct and indirect optical band gaps, as well as the Urbach energy were calculated. It is observed that both the direct and indirect optical band gaps increase with the concentration of Dy3+ ions. On the other hand, the Urbach energy is observed to decrease as the concentration of Dy3+ ions increases.

  6. Isolation of {sup 163}Ho from dysprosium target material by HPLC for neutrino mass measurements

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Veronika; Taylor, Wayne A.; Nortier, Francois M.; Engle, Jonathan W.; Pollington, Anthony D.; Kunde, Gerd J.; Rabin, Michael W.; Birnbaum, Eva R. [Los Alamos National Laboratory, Los Alamos, NM (United States). Chemistry Div.; Barnhart, Todd E.; Nickles, Robert J. [Univ. Wisconsinn, Madison, WI (United States). Dept. of Medical Physics

    2015-07-01

    The rare earth isotope {sup 163}Ho is of interest for neutrino mass measurements. This report describes the isolation of {sup 163}Ho from a proton-irradiated dysprosium target and its purification. A Dy metal target was irradiated with 16 MeV protons for 10 h. After target dissolution, {sup 163}Ho was separated from the bulk Dy via cation-exchange high performance liquid chromatography using 70 mmol dm{sup -3} α-hydroxyisobutyric acid as the mobile phase. Subsequent purification of the collected Ho fraction was performed to remove the α-hydroxyisobutyrate chelating agent and to concentrate the Ho in a low ionic strength aqueous matrix. The final solution was characterized by MC-ICP-MS to determine the {sup 163}Ho/{sup 165}Ho ratio, {sup 163}Ho and the residual Dy content. The HPLC purification process resulted in a decontamination factor 1.4 x 10{sup 5} for Dy. The isolated Ho fraction contained 24.8 ± 1.3 ng of {sup 163}Ho corresponding to holmium recovery of 72 ± 3%.

  7. Dicty_cDB: CHR140 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ontig-U15613-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHR1-B/CHR140Q....Seq.d/ Representative seq. ID CHR140P (Link to Original site) Representative DNA sequence >CHR140 (CHR140Q...) /CSM/CH/CHR1-B/CHR140Q.Seq.d/ AAAAAAAGTTTTAATCACTATTAAAAATATATATATTATAATTGTCAATTTTTATTCGTA TAATTTAT...yfphfnscgfisk *nl*ksl*rl Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHR140 (CHR140Q...) /CSM/CH/CHR1-B/CHR140Q.Seq.d/ 1118 0.0 CHI179 (CHI179Q) /CSM/

  8. Acute dysprosium toxicity to Daphnia pulex and Hyalella azteca and development of the biotic ligand approach.

    Science.gov (United States)

    Vukov, Oliver; Smith, D Scott; McGeer, James C

    2016-01-01

    The toxicological understanding of rare earth elements (REEs) in the aquatic environment is very limited but of increasing concern. The objective of this research is to compare the toxicological effect of the REE dysprosium to the freshwater invertebrates Daphnia pulex and Hyalella azteca and in the more sensitive organism, understand the toxicity modifying influence of Ca, Na, Mg, pH and dissolved organic matter (DOM). Standard methods (Environment Canada) were followed for testing and culture in media of intermediate hardness (60mg CaCO3 mg/L) at pH 7.8 with Ca at 0.5, Na 0.5, Mg 0.125 (mM) and 23°C. Acute toxicity tests were done with azteca and D. pulex revealed Hyalella to be 1.4 times more sensitive than Daphnia. Additions of Ca and Na but not Mg provided significant protection against Dy toxicity to Hyalella. Similarly, low pH was associated with reduction in toxicity. Exposures which were pH buffered with and without MOPS were significantly different and indicated that MOPS enhanced Dy toxicity. DOM also mitigated Dy toxicity. Biotic ligand based parameters (LogK values) were calculated based on free ion relationships as determined by geochemical equilibrium modeling software (WHAM ver. 7.02). The logK value for Dy(3+) toxicity to Hyalella was 7.75 while the protective influence of Ca and Na were 3.95 and 4.10, respectively. This study contributes data towards the development of site specific water quality guidelines and criteria for Dy and possibly REEs in general and offers insight into the complex bio-geochemical nature of this element.

  9. 24 CFR 583.140 - Technical assistance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Technical assistance. 583.140... Technical assistance. (a) General. HUD may set aside funds annually to provide technical assistance, either... technical assistance is for the purpose of promoting the development of supportive housing and supportive...

  10. Mapping of p140Cap phosphorylation sites

    DEFF Research Database (Denmark)

    Repetto, Daniele; Aramu, Simona; Boeri Erba, Elisabetta

    2013-01-01

    Protein phosphorylation tightly regulates specific binding of effector proteins that control many diverse biological functions of cells (e. g. signaling, migration and proliferation). p140Cap is an adaptor protein, specifically expressed in brain, testis and epithelial cells, that undergoes phosp...

  11. 38 CFR 51.140 - Dietary services.

    Science.gov (United States)

    2010-07-01

    ... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.140 Dietary services. The facility... nutritional and special dietary needs of each resident. (a) Staffing. The facility management must employ a... personnel competent to carry out the functions of the dietary service. (c) Menus and nutritional...

  12. 38 CFR 52.140 - Dietary services.

    Science.gov (United States)

    2010-07-01

    ... FOR ADULT DAY HEALTH CARE OF VETERANS IN STATE HOMES Standards § 52.140 Dietary services. The program... meets the daily nutritional and special dietary needs of each participant. (a) Food and nutritional... provide nutritional guidance. (2) A qualified dietitian is one who is qualified based upon registration...

  13. 45 CFR 1706.140 - Employment.

    Science.gov (United States)

    2010-10-01

    ... Welfare Regulations Relating to Public Welfare (Continued) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.140 Employment. No...

  14. 23 CFR 140.906 - Labor costs.

    Science.gov (United States)

    2010-04-01

    ... Railroad Work § 140.906 Labor costs. (a) General. (1) Salaries and wages, at actual or average rates, and... engineering, construction engineering, right-of-way, and force account construction. (2) Salaries and expenses... may be reimbursed. (b) Labor surcharges. (1) Labor surcharges include worker compensation...

  15. 9 CFR 319.140 - Sausage.

    Science.gov (United States)

    2010-01-01

    ... CFR Chapter III, Subchapter E, or in 21 CFR Chapter I, Subchapter A or Subchapter B. In addition to... permitting that use in this subchapter or in 9 CFR Chapter III, Subchapter E, or in 21 CFR Chapter I... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Sausage. 319.140 Section...

  16. Optical trapping of ultracold dysprosium atoms: transition probabilities, dynamic dipole polarizabilities and van der Waals C 6 coefficients

    Science.gov (United States)

    Li, H.; Wyart, J.-F.; Dulieu, O.; Nascimbène, S.; Lepers, M.

    2017-01-01

    The efficiency of the optical trapping of ultracold atoms depends on the atomic dynamic dipole polarizability governing the atom-field interaction. In this article, we have calculated the real and imaginary parts of the dynamic dipole polarizability of dysprosium in the ground and first excited levels. Due to the high electronic angular momentum of those two states, the polarizabilities possess scalar, vector and tensor contributions that we have computed, on a wide range of trapping wavelengths, using the sum-over-state formula. Using the same formalism, we have also calculated the C 6 coefficients characterizing the van der Waals interaction between two dysprosium atoms in the two lowest levels. We have computed the energies of excited states and the transition probabilities appearing in the sums, using a combination of ab initio and least-square-fitting techniques provided by the Cowan codes and extended in our group. Regarding the real part of the polarizability, for field frequencies far from atomic resonances, the vector and tensor contributions are two-orders-of-magnitude smaller than the scalar contribution, whereas for the imaginary part, the vector and tensor contributions represent a noticeable fraction of the scalar contribution. Finally, our anisotropic C 6 coefficients are much smaller than those published in the literature.

  17. Dicty_cDB: SLB140 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB140 (Link to dictyBase) - - - Contig-U16455-1 SLB140Z (Link... to Original site) - - SLB140Z 723 - - - - Show SLB140 Library SL (Link to library) Clone ID SLB140 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB1-B/SLB140Q.Seq.d/ Representative seq. ID SLB14...0Z (Link to Original site) Representative DNA sequence >SLB140 (SLB140Q) /CSM/SL/SLB1-B/SLB140Q.Seq.d/ XXXXX...3 0.0 SLE193 (SLE193Q) /CSM/SL/SLE1-D/SLE193Q.Seq.d/ 1403 0.0 SLB795 (SLB795Q) /CSM/SL/SLB7-D/SLB795Q.Seq.d/ 1403 0.0 SLB249 (SLB

  18. Hugoniot model for Si from L140

    Energy Technology Data Exchange (ETDEWEB)

    Whitley, H. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wu, C. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-09-20

    In this document, we provide the Hugoniot for silicon from LEOS table L140. The Hugoniot pressures are supplied for temperatures between 298.0 and 1:16 109 Kelvin and densities of 2.329 and 10.07 g/cc. This EOS model was developed by the quotidian EOS methodology, which is a widely used and robust method for producing tabular EOS data.[1, 2] Table 1 lists the included quantities and units of those data.

  19. Acute dysprosium toxicity to Daphnia pulex and Hyalella azteca and development of the biotic ligand approach

    Energy Technology Data Exchange (ETDEWEB)

    Vukov, Oliver, E-mail: vuko3930@mylaurier.ca [Biology Department, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5 (Canada); Smith, D. Scott [Chemistry Department, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5 (Canada); McGeer, James C. [Biology Department, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5 (Canada)

    2016-01-15

    The toxicological understanding of rare earth elements (REEs) in the aquatic environment is very limited but of increasing concern. The objective of this research is to compare the toxicological effect of the REE dysprosium to the freshwater invertebrates Daphnia pulex and Hyalella azteca and in the more sensitive organism, understand the toxicity modifying influence of Ca, Na, Mg, pH and dissolved organic matter (DOM). Standard methods (Environment Canada) were followed for testing and culture in media of intermediate hardness (60 mg CaCO{sub 3} mg/L) at pH 7.8 with Ca at 0.5, Na 0.5, Mg 0.125 (mM) and 23 °C. Acute toxicity tests were done with <24 h old neonates for 48 h in the case of D. pulex and with 2–9 days old offspring for 96 h tests with Hyalella. The potential protective effect of cationic competition was tested with Ca (0.5–2.0 mM), Na (0.5–2.0 mM) and Mg (0.125–0.5 mM). The effect of pH (6.5–8.0) and Suwannee River DOM complexation (at dissolved organic carbon (DOC) concentrations of 9 and 13 mg C/L) were evaluated. Dissolved Dy concentrations were lower than total (unfiltered) indicating precipitation, particularly at higher concentrations. Acute toxicity of Dy to H. azteca and D. pulex revealed Hyalella to be 1.4 times more sensitive than Daphnia. Additions of Ca and Na but not Mg provided significant protection against Dy toxicity to Hyalella. Similarly, low pH was associated with reduction in toxicity. Exposures which were pH buffered with and without MOPS were significantly different and indicated that MOPS enhanced Dy toxicity. DOM also mitigated Dy toxicity. Biotic ligand based parameters (Log K values) were calculated based on free ion relationships as determined by geochemical equilibrium modeling software (WHAM ver. 7.02). The log K value for Dy{sup 3+} toxicity to Hyalella was 7.75 while the protective influence of Ca and Na were 3.95 and 4.10, respectively. This study contributes data towards the development of site specific

  20. White light emission of dysprosium doped lanthanum calcium phosphate oxide and oxyfluoride glasses

    Science.gov (United States)

    Luewarasirikul, N.; Kim, H. J.; Meejitpaisan, P.; Kaewkhao, J.

    2017-04-01

    Lanthanum calcium phosphate oxide and oxyfluoride glasses doped with dysprosium oxide were prepared by melt-quenching technique with chemical composition 20La2O3:10CaO:69P2O5:1Dy2O3 and 20La2O3:10CaF2:69P2O5:1Dy2O3. The physical, optical and luminescence properties of the glass samples were studied to evaluate their potential to using as luminescence materials for solid-state lighting applications. The density, molar volume and refractive index of the glass samples were carried out. The optical and luminescence properties were studied by investigating absorption, excitation, and emission spectra of the glass samples. The absorption spectra were investigated in the UV-Vis-NIR region from 300 to 2000 nm. The excitation spectra observed under 574 nm emission wavelength showed the highest peak centered at 349 nm (6H15/2 → 6P7/2). The emission spectra, excited with 349 nm excitation wavelength showed two major peaks corresponding to 482 nm blue emission (4F9/2 → 6H15/2) and 574 nm yellow emission (4F9/2 → 6H13/2). The experimental lifetime were found to be 0.539 and 0.540 for oxide and oxyfluoride glass sample, respectively. The x,y color coordinates under 349 nm excitation wavelength were (0.38, 0.43) for both glass samples, that be plotted in white region of CIE 1931 chromaticity diagram. The CCT values obtained from the glass samples are 4204 K for oxide glass and 4228 K for oxyfluoride glass corresponding to the commercial cool white light (3100-4500 K). Judd-Ofelt theory had also been employed to obtain the J-O parameters (Ω2, Ω4 and Ω6), oscillator strength, radiative transition possibility, stimulated emission cross section and branching ratio. The Ω2 > Ω4 > Ω6 trend of J-O parameters of both glass samples may indicate the good quality of a glass host for using as optical device application. Temperature dependence of emission spectra was studied from 300 K to 10 K and found that the intensity of the emission peak was found to be increased with

  1. 宏基beTouch E140

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    看来宏基为进军手机市场费了不少心思。这款定位入门级的beTouch E140尽管并未成为众人瞩目的焦点,但硬件配置却毫不含糊,还搭载了Android OS v2.2系统。与它们一起发布的还有一款全键盘E210,喜欢全键盘的米饭不妨去关注一下。

  2. Limits on violations of Lorentz symmetry and the Einstein equivalence principle using radio-frequency spectroscopy of atomic dysprosium.

    Science.gov (United States)

    Hohensee, M A; Leefer, N; Budker, D; Harabati, C; Dzuba, V A; Flambaum, V V

    2013-08-02

    We report a joint test of local Lorentz invariance and the Einstein equivalence principle for electrons, using long-term measurements of the transition frequency between two nearly degenerate states of atomic dysprosium. We present many-body calculations which demonstrate that the energy splitting of these states is particularly sensitive to violations of both special and general relativity. We limit Lorentz violation for electrons at the level of 10(-17), matching or improving the best laboratory and astrophysical limits by up to a factor of 10, and improve bounds on gravitational redshift anomalies for electrons by 2 orders of magnitude, to 10(-8). With some enhancements, our experiment may be sensitive to Lorentz violation at the level of 9 × 10(-20).

  3. Nonlinear optical properties of lutetium and dysprosium bisphthalocyanines at 1550 nm with femto- and nanosecond pulse excitation

    Science.gov (United States)

    Plekhanov, A. I.; Basova, T. V.; Parkhomenko, R. G.; Gürek, A. G.

    2017-02-01

    In this work, the nonlinear optical properties of unsubstituted lutetium (LuPc2) and dysprosium (DyPc2) bisphthalocyanines as well as octasubstituted Lu(PcR8)2 derivative with R=-S(C6H13) were studied at a wavelength of 1550 nm with 10 ns and 300 fs pulses. Based on Z-scan measurements the nonlinear absorption and refraction coefficient as well as the nature of nonlinear optical properties were analyzed for these materials. Open aperture Z-scan indicates strong two-photon absorption in all three bisphthalocyanines in nano- and femtosecond regimes. With good nonlinear optical coefficients, bisphthalocyanines of rare earth elements are expected to be promising materials for the creation of optical limiters.

  4. European wind variability over 140 years

    CERN Document Server

    Bett, Philip; Clark, Robin

    2013-01-01

    We present initial results of a study on the variability of wind speeds across Europe over the past 140 years, making use of the recent Twentieth Century Reanalysis data set, which includes uncertainty estimates from an ensemble method of reanalysis. Maps of the means and standard deviations of daily wind speeds, and the Weibull-distribution parameters, show the expected features, such as the strong, highly-variable wind in the north-east Atlantic. We do not find any clear, strong long-term trends in wind speeds across Europe, and the variability between decades is large. We examine how different years and decades are related in the long-term context, by looking at the ranking of annual mean wind speeds. Such analyses show, for example, that the wind speeds in eastern England over the past ~20 years are within the range expected from natural variability, but do not span the full range of variability from the full 140-year data set. However, the calendar-year 2010 is found to have the lowest mean wind speed of...

  5. 13 CFR 140.1 - What does this part cover?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What does this part cover? 140.1 Section 140.1 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DEBT COLLECTION Overview § 140... failure to comply with any provision of the regulations in this part is not available to any debtor as...

  6. 27 CFR 27.140 - Certification requirements for wine.

    Science.gov (United States)

    2010-04-01

    ... for wine. 27.140 Section 27.140 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS IMPORTATION OF DISTILLED SPIRITS, WINES, AND BEER Importer's Records and Reports Other Records § 27.140 Certification requirements for wine. (a) Definitions...

  7. 33 CFR 140.4 - Relationship to other law.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Relationship to other law. 140.4 Section 140.4 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES GENERAL General § 140.4 Relationship to other law. (a) Design and...

  8. 40 CFR 52.140 - Monitoring transportation trends.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Monitoring transportation trends. 52.140 Section 52.140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.140 Monitoring...

  9. 23 CFR 140.914 - Credits for improvements.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Credits for improvements. 140.914 Section 140.914... Reimbursement for Railroad Work § 140.914 Credits for improvements. (a) Credit shall be made to the project for... depreciable structures of a company which are integral to operation of rail traffic must be replaced, credit...

  10. Spectroscopic data of the 1.8-, 2.9-, and 4.3- mu m transitions in dysprosium-doped gallium lanthanum sulfide glass

    Science.gov (United States)

    Schweizer, T.; Hewak, D. W.; Samson, B. N.; Payne, D. N.

    1996-10-01

    Infrared emission at 1.8, 2.9, and 4.3 mu m is measured in dysprosium-doped gallium lanthanum sulfide (Ga:La:S) glass excited at 815 nm. Emission cross sections were calculated by Judd-Ofelt analysis, the Fuchtbauer-Ladenburg equation, and the theory of McCumber. The sigma tau value for the 4.3- mu m transition is \\similar 4000 times larger in the Ga:La:S glass than in a dysprosium-doped LiYF4 crystal, which has lased on this transition. The large sigma tau value and the recently reported ability of Ga:La:S glass to be fabricated into fiber form show the potential for an efficient, low-threshold mid-infrared fiber laser. The fluorescence peak at 4.3 mu m coincides with the fundamental absorption of atmospheric carbon dioxide, making the glass a potential laser source for gas-sensing applications.

  11. Spectroscopic data of the 1.8-, 2.9-, and 4.3-microm transitions in dysprosium-doped gallium lanthanum sulfide glass.

    Science.gov (United States)

    Schweizer, T; Hewak, D W; Samson, B N; Payne, D N

    1996-10-01

    Infrared emission at 1.8, 2.9, and 4.3 microm is measured in dysprosium-doped gallium lanthanum sulfide (Ga:La:S) glass excited at 815 nm. Emission cross sections were calculated by Judd-Ofelt analysis, the Füchtbauer- Ladenburg equation, and the theory of McCumber. The sigmatau value for the 4.3-microm transition is ~4000 times larger in the Ga:La:S glass than in a dysprosium-doped LiYF(4) crystal, which has lased on this transition. The large sigmatau value and the recently reported ability of Ga:La:S glass to be fabricated into fiber form show the potential for an efficient, low-threshold mid-infrared fiber laser. The f luorescence peak at 4.3 microm coincides with the fundamental absorption of atmospheric carbon dioxide, making the glass a potential laser source for gas-sensing applications.

  12. On-line complexation/cloud point preconcentration for the sensitive determination of dysprosium in urine by flow injection inductively coupled plasma-optical emission spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Claudia; Cerutti, Soledad; Silva, Maria F. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Olsina, Roberto A.; Martinez, Luis D. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Avda. Rivadavia 1917, CP C1033AAJJ, Buenos Aires (Argentina)

    2003-01-01

    An on-line dysprosium preconcentration and determination system based on the hyphenation of cloud point extraction (CPE) to flow injection analysis (FIA) associated with ICP-OES was studied. For the preconcentration of dysprosium, a Dy(III)-2-(5-bromo-2-pyridylazo)-5-diethylaminophenol complex was formed on-line at pH 9.22 in the presence of nonionic micelles of PONPE-7.5. The micellar system containing the complex was thermostated at 30 C in order to promote phase separation, and the surfactant-rich phase was retained in a microcolumn packed with cotton at pH 9.2. The surfactant-rich phase was eluted with 4 mol L{sup -1} nitric acid at a flow rate of 1.5 mL min{sup -1}, directly in the nebulizer of the plasma. An enhancement factor of 50 was obtained for the preconcentration of 50 mL of sample solution. The detection limit value for the preconcentration of 50 mL of aqueous solution of Dy was 0.03 {mu}g L{sup -1}. The precision for 10 replicate determinations at the 2.0 {mu}g L{sup -1}Dy level was 2.2% relative standard deviation (RSD), calculated from the peak heights obtained. The calibration graph using the preconcentration system for dysprosium was linear with a correlation coefficient of 0.9994 at levels near the detection limits up to at least 100 {mu}g L {sup -1}. The method was successfully applied to the determination of dysprosium in urine. (orig.)

  13. Absorption heat pump with an average efficiency of 140%. Absorptiewarmtepomp haalt gemiddeld rendement van 140%

    Energy Technology Data Exchange (ETDEWEB)

    Langreck, J. (Colibri BV, Landgraaf (Netherlands))

    1994-09-01

    A description is given of a new type of absorption heat pump in which ammonia/water is applied as the working fluid. With the first sample in the provincial government building in Maastricht, Netherlands, and efficiency of 140% has been realized. A brief overview is given of the costs of and the market for this new type of heat pump. 2 figs., 1 ill., 3 tabs., 1 ref.

  14. [Nephritic colic. Analysis of 140 cases].

    Science.gov (United States)

    Amat Cecilia, M; Romero Pérez, P

    1994-10-01

    A nephritic colic is one of the most common pictures of urologic conditions, a primary causes being the occurrence of lithiasis concretions along the urinary tract. A series of 140 cases of nephritic colic diagnosed in the emergency ward and later referred to our office for follow-up are presented here. The relevance of the physical examination is emphasized, pointing out that with practice the simple performance of abdominal X-ray, ultrasound and urinary sediments is usually enough to reach a certainty diagnosis. There is, however, near 10% cases where it is necessary to carry out contrast studies or endoscopic manoeuvres to be able to differentiate a nephritic colic from other conditions. The primary aim of treatment is to overcome pain, facilitate the advance of the lithiasis obstacle and to preserve the renal function. A description is made of the various drugs used, while endoscopic manoeuvres are reserved for the more selected cases of compromised kidney or when the patient's general condition so requires.

  15. Dicty_cDB: SHB140 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0.0 SHB140 (SHB140Q) /CSM/SH/SHB1-B/SHB140Q.Seq.d/ 761 0.0 SHA484 (SHA484Q) /CSM/SH/SHA4-D/SHA484Q.Seq.d/ 761 0.0 SHA293 (SHA29...3Q) /CSM/SH/SHA2-D/SHA293Q.Seq.d/ 761 0.0 CHS310 (CHS310Q) /CS

  16. Synthesis and Crystal Structure of Tri-(2-mercaptopyridine N-oxide)bis(dimethyl sulfoxide) Dysprosium(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A range of rare earth metal complexes of 2-mercaptopyridine N-oxide (Hmpo) have been synthesized, and studied by elemental analysis and IR spectroscopic technique. Crystal structure of Dy(mpo)3(DMSO)2 (DMSO = dimethyl sulfoxide) has been determined. The complex crystallizes in the triclinic system, space group Pī with lattice parameters: a = 9.602(3), b = 9.803(3), c = 15.498(5)A, α= 89.51(1), β= 85.73(1), γ= 62.99(1)°, Dc = 1.787 g/cm3, C19H24N3O5S5Dy, Mr = 697.21, Z = 2, F(000) = 690, μ = 3.321mm-1, the final R = 0.0237 and wR = 0.0587 for 4116 reflections with I>σ2(I). The coordination number of dysprosium Ⅲ is eight, and its coordination geometry is a somewhat distorted square antiprism with O(3), O(4), O(5), S(3) and O(1), O(2), S(1), S(2) at the tetragonal bases (dihedral angle between their mean planes is 2.9(1)0). Around the Dy atom, three five-membered ring planes (Dy, O, N, C, S) make the dihedral angles of 74.42, 11.31 and 83.72, respectively.

  17. Photo-, cathodo- and thermoluminescent properties of dysprosium-doped HfO2 films deposited by ultrasonic spray pyrolysis.

    Science.gov (United States)

    Manríquez, R Reynoso; Góngora, J A I Díaz; Guzmán-Mendoza, J; Montalvo, T Rivera; Olguín, J C Guzmán; Ramírez, P V Cerón; García-Hipólito, M; Falcony, C

    2014-09-01

    In this work, the photoluminescent (PL), cathodoluminescent (CL) and thermoluminescent (TL) properties of hafnium oxide films doped with trivalent dysprosium ions are reported. The films were deposited on glass substrates at temperatures ranging from 300 to 600°C, using chlorides as precursor reagents. The surface morphology of films showed a veins shaped microstructure at low deposition temperatures, while at higher temperatures the formation of spherical particles was observed on the surface. X-ray diffraction showed the presence of HfO2 monoclinic phase in the films deposited at temperatures greater than 400°C. The PL and CL spectra of the doped films showed the highest emission band centered at 575nm corresponding to the transitions (4)F9/2→(6)H13/2, which is a characteristic transition of Dy(3+) ion. The greatest emission intensities were observed in samples doped with 1 atomic percent (at%) of DyCl3 in the precursor solution. Regarding the TL behavior, the glow curve of HfO2:Dy(+3) films exhibited spectrum with one broad band centered at about 150°C. The highest intensity TL response was observed on the films deposited at 500°C. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Workplace testing of the new single sphere neutron spectrometer based on Dysprosium activation foils (Dy-SSS)

    Science.gov (United States)

    Bedogni, R.; Gómez-Ros, J. M.; Esposito, A.; Gentile, A.; Chiti, M.; Palacios-Pérez, L.; Angelone, M.; Tana, L.

    2012-08-01

    A photon insensitive passive neutron spectrometer consisting of a single moderating polyethylene sphere with Dysprosium activation foils arranged along three perpendicular axes was designed by CIEMAT and INFN. The device is called Dy-SSS (Dy foil-based Single Sphere Spectrometer). It shows nearly isotropic response in terms of neutron fluence up to 20 MeV. The first prototype, previously calibrated with 14 MeV neutrons, has been recently tested in workplaces having different energy and directional distributions. These are a 2.5 MeV nearly mono-chromatic and mono-directional beam available at the ENEA Frascati Neutron Generator (FNG) and the photo-neutron field produced in a 15 MV Varian CLINAC DHX medical accelerator, located in the Ospedale S. Chiara (Pisa). Both neutron spectra are known through measurements with a Bonner Sphere Spectrometer. In both cases the experimental response of the Dy-SSS agrees with the reference data. Moreover, it is demonstrated that the spectrometric capability of the new device are independent from the directional distribution of the neutron field. This opens the way to a new generation of moderation-based neutron instruments, presenting all advantages of the Bonner sphere spectrometer without the disadvantage of the repeated exposures. This concept is being developed within the NESCOFI@BTF project of INFN (Commissione Scientifica Nazionale 5).

  19. Ferroelectric properties of dysprosium-doped Bi4Ti3O12 thin films crystallized in various atmospheres

    Institute of Scientific and Technical Information of China (English)

    CHENG Chuan-pin; TANG Ming-hua; YE Zhi; ZHOU Yic-hun; ZHENG Xue-jun; ZHONG Xiang-li; HU Zeng-shun

    2006-01-01

    Dysprosium-doped Bi4Ti3O12 (Bi3.4Dy0.6Ti3O12,BDT) ferroelectric thin films were deposited on Pt(111)/Ti/SiO2/Si(111) substrates by chemical solution deposition (CSD) and crystallized in nitrogen,air and oxygen atmospheres,respectively. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to identify the crystal structure,the surface and cross-section morphology of the deposited ferroelectric films. The results show that the crystallization atmosphere has significant effect on determining the crystallization and ferroelectric properties of the BDT films. The film crystallized in nitrogen at a relatively low temperature of 650 ℃,exhibits excellent crystallinity and ferroelectricity with a remanent polarization of 2Pr = 24.9 μC/cm2 and a coercive field of 144.5 kV/cm. While the films annealed in air and oxygen at 650 ℃ do not show good crystallinity and ferroelectricity until they are annealed at 700 ℃. The structure evolution and ferroelectric properties of BDT thin films annealed under different temperatures (600-750 ℃) were also investigated. The crystallinity of the BDT films is improved and the average grain size increases when the annealing temperature increases from 600 ℃ to 750 ℃ at an interval of 50 ℃. However,the polarization of the films is not monotonous function of the annealing temperature.

  20. 32 CFR 935.140 - Motor vehicle maintenance and equipment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Motor vehicle maintenance and equipment. 935.140... AND INSULAR REGULATIONS WAKE ISLAND CODE Motor Vehicle Code § 935.140 Motor vehicle maintenance and equipment. (a) Each person who has custody of a motor vehicle on Wake Island shall present that vehicle...

  1. 21 CFR 163.140 - Skim milk chocolate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Skim milk chocolate. 163.140 Section 163.140 Food... milk chocolate. (a) Description. Skim milk chocolate is the food that conforms to the standard of identity, and is subject to the requirements for label declaration of ingredients for milk chocolate in...

  2. 25 CFR 140.23 - Credit at trader's risk.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Credit at trader's risk. 140.23 Section 140.23 Indians....23 Credit at trader's risk. Credit given Indians will be at the trader's own risk, as no assistance... accept pawns or pledges of personal property by Indians to obtain credit or loans. ...

  3. 7 CFR 915.140 - Avocados not subject to regulation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Avocados not subject to regulation. 915.140 Section... SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Rules and Regulations § 915.140 Avocados not subject to regulation. (a)...

  4. 50 CFR 665.140 - American Samoa Crustacean Fisheries. [Reserved

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false American Samoa Crustacean Fisheries. 665.140 Section 665.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC American...

  5. 21 CFR 139.140 - Wheat and soy macaroni products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Wheat and soy macaroni products. 139.140 Section... Macaroni and Noodle Products § 139.140 Wheat and soy macaroni products. (a) Wheat and soy macaroni products... percent of the combined weight of the wheat and soy ingredients used (the soy flour used is made from...

  6. 50 CFR 648.140 - Catch quotas and other restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Catch quotas and other restrictions. 648.140 Section 648.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... exploitation rate of 23 percent (based on Fmax) in 2003 and subsequent years: Commercial, recreational,...

  7. 40 CFR 97.140 - State trading budgets.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false State trading budgets. 97.140 Section...) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR NOX Allowance Allocations § 97.140 State trading budgets. The State trading budgets for annual allocations of CAIR NOX...

  8. 40 CFR 96.140 - State trading budgets.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false State trading budgets. 96.140 Section...) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR NOX Allowance Allocations § 96.140 State trading budgets. The State trading budgets for...

  9. Sensitive search for the temporal variation of the fine structure constant using radio-frequency E1 transitions in atomic dysprosium

    CERN Document Server

    Nguyen, A T; Lamoreaux, S K; Torgerson, J R

    2003-01-01

    It has been proposed that the radio-frequency electric-dipole (E1) transition between two nearly degenerate opposite-parity states in atomic dysprosium should be highly sensitive to possible temporal variation of the fine structure constant ($\\alpha$) [V. A. Dzuba, V. V. Flambaum, and J. K. Webb, Phys. Rev. A {\\bf 59}, 230 (1999)]. We discuss here an experimental realization of the proposed search, which involves monitoring the E1 transition frequency over a period of time using direct frequency counting techniques. We estimate that a statistical sensitivity of $|\\adota| \\sim 10^{-18}$/yr may be achieved and discuss possible systematic effects in such a measurement.

  10. A Comparison of the Security Requirements for Cryptographic Modules in FIPS 140-1 and FIPS 140-2

    Science.gov (United States)

    2001-06-01

    and Interfaces 4.3 Roles and Services 4.3 Roles, Services, and Authentication* 4.4 Finite State Machine Model 4.4 Finite State...operator.” 3.3.4. Finite State Model The area has been renamed (from Finite State Machine Model in FIPS 140-1 to Finite State Model in FIPS 140-2

  11. Roles of RIP140 in various tissues%RIP140在各种组织中的作用

    Institute of Scientific and Technical Information of China (English)

    匡海军; 陈五军; 张敏; 曾高峰; 唐朝克

    2013-01-01

    受体相互作用蛋白140 (receptor-interacting protein 140,RIP140)作为一种转录辅抑制因子,参与机体代谢调节.RIP140与核受体结合后能够负向调节脂肪、肌肉、心肌以及肝脏等多种组织中靶基因的转录.对其进行靶向沉默可上调多种组织中相关基因的表达,影响糖酵解、甘油三酯代谢、三羧酸循环、脂肪酸β氧化、炎症因子表达以及机体时钟变化等多种代谢过程,因此RIP140有望成为治疗代谢综合征的候选靶点.%As a transcription auxiliary inhibitor, receptor-interacting protein 140 (RIP 140) is involved in the regulation of metabolism in human body. Once combined with nuclear receptor, RIP 140 can negatively regulate the transcription of target genes within a variety of metabolic organizations include the adipose tissue, muscle tissue, cardiac muscle and liver. When silenced, on the contrary, RIP 140 will have an influence on glycolysis, triglyceride metabolism, the tricarboxylic acid cycle, fatty acid β oxidation, inflammatory factor expression, the body clock changes, etc. Therefore RIP 140 promises to be a candidate target site for the treatment of metabolic syndrome.

  12. 22 CFR 140.7 - Multilateral institutions and international organizations.

    Science.gov (United States)

    2010-04-01

    ... TO DRUG TRAFFICKERS Enforcement § 140.7 Multilateral institutions and international organizations. Assistance provided to or through multilateral institutions or international organizations is subject to this... that a recipient multilateral institution or international organization may be or may have...

  13. Dysprosium doping induced shape and magnetic anisotropy of Fe3-xDyxO4 (x=0.01-0.1) nanoparticles

    Science.gov (United States)

    Jain, Richa; Luthra, Vandna; Gokhale, Shubha

    2016-09-01

    The effect of dysprosium doping on evolution of structural and magnetic properties of magnetite (Fe3O4) nanoparticles is reported. A standard route of co-precipitation was used for the synthesis of undoped and doped magnetite nanoparticles Fe3-xDyxO4 (x=0.0-0.1). Transmission electron microscopy (TEM) shows formation of round shaped particles with diameter in the range of 8-14 nm for undoped sample. On doping beyond x=0.01, the formation of rod like structures is initiated along with the round shaped particles. The number of rods is found to increase with increasing doping concentration. Magnetic characterization using Vibrating Sample Magnetometer (VSM) revealed doping dependent magnetic properties which can be correlated with the crystallite size as determined from X-ray diffraction (XRD). Enhancement in the saturation magnetization in the initial stages of doping can be explained on the basis of incorporation of Dy3+ ions in the inverse spinel structure at the octahedral site in place of Fe3+ ions. Subsequent decrease in saturation magnetization observed beyond x=0.03 could be attributed to precipitation of excess Dy in form of dysprosium ferrite phase.

  14. PRO 140--a novel CCR5 co-receptor inhibitor.

    Science.gov (United States)

    Khatib, Nadia; Das, Satyajit

    2010-01-01

    Despite an increase in the variety of anti-retroviral agents in the market, there remains a need for novel agents to treat HIV 1 infected individuals, in order to overcome existing problems with adherence, toxicities, drug interactions and viral resistance. In this article, we will describe Pro 140, one of the recently developed class of anti-retroviral agent, the CCR5 co-receptor inhibitor. We will also describe several preclinical and clinical studies that have evaluated the efficacy, tolerability and toxicity profiles of Pro-140. We will also look at how its mechanism of action and mode of delivery may change the way patients take highly active anti-retroviral therapy. There are some promising patents discussed in this short review for the use of PRO 140 as CCR5 co-receptor Inhibitor.

  15. Determination of the magnetic moment of $^{140}$Pr

    CERN Multimedia

    Kowalska, M; Kreim, K D; Krieger, A R; Litvinov, Y

    We propose to measure the nuclear magnetic moment of the neutron-deficient isotope $^{140}$Pr using collinear laser spectroscopy at the COLLAPS experiment. This nuclide is one of two nuclear systems for which a modulated electron capture decay has been observed in hydrogen-like ions in a storage ring. The firm explanation of the observed phenomenon is still missing but some hypotheses suggest an interaction of the unpaired electron with the surrounding magnetic fields of the ring. In order to verify or discard these hypotheses the magnetic moment of $^{140}$Pr is required since this determines the energy of the 1s hyperfine splitting.

  16. GP140/CDCPI in the Development of Prostate Cancer Metastasis

    Science.gov (United States)

    2013-09-01

    RM: The pluripotency of hair follicle stem cells. Cell Cycle 2006, 5:232–233 54. Hirst CE, Ng ES, Azzola L, Voss AK, Thomas T, Stanley EG, Elefanty...analyze the role of gp140/CDCP1 in prostate cancer metastasis and to determine whether targeting gp140/CDCP1 could serve as a treatment against...KS, Xin H: Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model. Cancer Res 2008, 68

  17. Single-molecule magnet behavior in an octanuclear dysprosium(iii) aggregate inherited from helical triangular Dy3 SMM-building blocks.

    Science.gov (United States)

    Zhang, Li; Zhang, Peng; Zhao, Lang; Wu, Jianfeng; Guo, Mei; Tang, Jinkui

    2016-06-28

    An unprecedented octanuclear dysprosium(iii) cluster with the formula [Dy8L6(μ3-OH)4(μ2-CH3O)2(CH3OH)6(H2O)2]·6H2O·10CH3OH·2CH3CN () based on a nonlinearly tritopic aroylhydrazone ligand H3L has been isolated, realizing the successful linking of pairwise interesting triangular Dy3 SMMs. It is noteworthy that two enantiomers (Λ and Δ configurations) individually behaving as a coordination-induced chirality presented in the Dy3 helicate are connected in the meso Dy8 cluster. Remarkably, alternating-current magnetic susceptibility measurements revealed that the Dy8 cluster shows typical SMM behavior inherited from its Dy3 helical precursor. It is one of the rare polynuclear Lnn SMMs (n > 7) under zero dc field.

  18. Another challenge to paramagnetic relaxation theory: a study of paramagnetic proton NMR relaxation in closely related series of pyridine-derivatised dysprosium complexes.

    Science.gov (United States)

    Rogers, Nicola J; Finney, Katie-Louise N A; Senanayake, P Kanthi; Parker, David

    2016-02-14

    Measurements of the relaxation rate behaviour of two series of dysprosium complexes have been performed in solution, over the field range 1.0 to 16.5 Tesla. The field dependence has been modelled using Bloch-Redfield-Wangsness theory, allowing estimates of the electronic relaxation time, T1e, and the size of the magnetic susceptibility, μeff, to be made. Changes in relaxation rate of the order of 50% at higher fields were measured, following variation of the para-substituent in the single pyridine donor. The magnetic susceptibilities deviated unexpectedly from the free-ion values for certain derivatives in each series examined, in a manner that was independent of the electron-releasing/withdrawing ability of the pyridine substituent, suggesting that the polarisability of just one pyridine donor in octadenate ligands can play a significant role in defining the magnetic susceptibility anisotropy.

  19. 7 CFR 1150.140 - Duties of the Board.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order National Dairy Promotion and Research Board § 1150.140 Duties of the Board. The Board shall...

  20. 38 CFR 59.140 - Nursing home care requirements.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Nursing home care... (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.140 Nursing home care... equipped for adequate nursing care, comfort, and privacy of residents. Resident rooms must: (1)...

  1. 9 CFR 381.140 - Relabeling poultry products.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Relabeling poultry products. 381.140... AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Labeling and Containers §...

  2. 7 CFR 1955.140 - Sale in parcels.

    Science.gov (United States)

    2010-01-01

    ..., inventory for small business enterprises, buildings, facilities, and similar items may be permitted if a... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.140 Sale in parcels...

  3. 17 CFR 140.24 - Control and accountability procedures.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Control and accountability... ORGANIZATION, FUNCTIONS, AND PROCEDURES OF THE COMMISSION Functions § 140.24 Control and accountability... accountability for such information at all times and for locking classified information in approved...

  4. 40 CFR 156.140 - Identification of container types.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Identification of container types. 156... PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.140 Identification of container types. For products other than plant-incorporated protectants, the following statements,...

  5. Phenotype abnormality: 140 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 140 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u646i decreased efficiency for trait of femal...n presence of 3-aminobutanoic_acid http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u43i ... decreased efficiency ... fertilization ... female fertility

  6. Weldability and Strength Recovery of NUCu-140 Advanced Naval Steel

    Science.gov (United States)

    Bono, Jason T.

    NUCu-140 is a ferritic copper-precipitation strengthened steel that is a candidate material for use in many naval and structural applications. Previous work has shown that the heat-affected zone (HAZ) and fusion zone (FZ) of NUCu-140 exhibit softening that is due to dissolution of the copper-rich precipitates. This study aims to recover the FZ and HAZ strength by re-precipitation of the copper-rich precipitates through either multiple weld passes or an isothermal post-weld heat treatment (PWHT). The potential use of multiple thermal cycles was investigated with HAZ simulations using a Gleeble thermomechanical simulator. The HAZ simulations represented two weld thermal cycles with different combinations of peak temperatures during the initial and secondary weld passes. To investigate the potential for a PWHT for strength recovery, gas tungsten arc weld (GTAW) samples were isothermally heated for various times and temperatures. Microhardness measurements revealed no strength recovery in the multipass HAZ samples. The time dependent precipitate characteristics were modeled under the HAZ thermal cycle conditions, and the results showed that the lack of strength recovery could be attributed to insufficient time for re-precipitation during the secondary weld pass. Conversely, full strength recovery in the HAZ was observed in the isothermally heat treated samples. Atom-probe tomography (APT) analysis correlated this strength recovery to re-precipitation of the copper-rich precipitates during the isothermal PWHT. The experimental naval steel known as NUCu-140 and an established naval steel HSLA-100 were subjected to stress-relief cracking (SRC) and hot-ductility testing to assess their relative cracking susceptibilities during the welding process and post weld heat treatment. NUCu-140 exhibited a longer time-to-failure (TTF) and a lower temperature of minimum TTF during SRC testing when compared to HSLA-100, indicating better resistance to SRC for the NUCu-140 steel. The

  7. Microblogging Marketing: 140 Words Gold Rush Game%微博营销:140字的淘金游戏

    Institute of Scientific and Technical Information of China (English)

    杨速炎

    2010-01-01

    @@ 微博商机初现 微博即微型博客,昵称"围脖",其主要功能是将生活中所看、所听、所想的内容,微缩成不超过140字的话语或一张图片,发到微博网页上,和自己的亲友以及所有有兴趣的网民分享.

  8. Tuning the composition and magnetostructure of dysprosium iron garnets by Co-substitution: An XRD, FT-IR, XPS and VSM study

    Energy Technology Data Exchange (ETDEWEB)

    Tholkappiyan, R.; Vishista, K., E-mail: raovishista@gmail.com

    2015-10-01

    Graphical abstract: - Highlights: • Garnet type Dy{sub 3}Fe{sub 5−x}Co{sub x}O{sub 12} (x = 0–0.06) nanoparticles were synthesized by glycine assisted combustion method. • To investigate and confirm the phases in the synthesized ferrite nanoparticles by FT-IR and XRD analysis. • To investigate the compositional and oxidation state of the samples by X-ray photoelectron spectroscopy. • The detailed core level spectra of Dy 4d, Fe 2p, Co 2p and O 1s were analyzed using XPS. • The magnetic property was studied by VSM technique. - Abstract: We report the Co-substituting on the synthesis and properties of garnet type dysprosium ferrite nanoparticles by basic composition Dy{sub 3}Fe{sub 5−x}Co{sub x}O{sub 12} (x = 0–0.06) synthesized through glycine assisted combustion method. A possible formation mechanism of synthesized Dy{sub 3}Fe{sub 5−x}Co{sub x}O{sub 12} samples by controlling the synthesis process has been proposed. XRD, FT-IR, XPS and VSM studies were used to investigate the compositional and magnetostructural properties of the prepared nanoparticles. XRD results confirm that all the samples are single-phase cubic garnet structure with mean crystallite size of 97–105 nm obtained from Scherrer method and 95–102 nm from W–H method. FT-IR analysis shows the presence of three expected bands in the frequency limit of 450–600 cm{sup −1} attributed to metal–O stretching vibration in tetrahedral site of garnet structure. A typical survey spectrum from XPS results confirmed the presence of Dy, Fe, Co and O elements in the samples. This study also to characterize the different oxidation states of the samples by fitting the parameters of high resolution Dy 4d, Fe 2p, Co 2p and O 1s XPS spectra. The XPS data of Dy 4d spectrum show that Dy{sup 3+} ion occupy in dodecahedral (D) site. The XPS analysis of Fe 2p and Co 2p data suggests that (Fe{sup 3+} and Fe{sup 2+}), (Co{sup 3+} and Co{sup 2+}) are distributed in tetrahedral and octahedral sites

  9. A three-year-old girl with IQ of 140

    Institute of Scientific and Technical Information of China (English)

    周鲁成

    2011-01-01

    英国埃塞克斯郡的一个名叫普莱德格(Saffron Pledger)的三岁女童,她的智商高达140,比美国前总统克林顿还聪明!年纪小小的她,已经会给七个月大的妹妹讲故事,目前已经成为英国天才组织“门萨”(Mensa)的第二个年轻的会员。

  10. 微小RNA-140及其与颌面部发育%MicroRNA-140 and its function in craniofacial development

    Institute of Scientific and Technical Information of China (English)

    李灵

    2011-01-01

    MicroRNA-140 is one of the factors that regulate craniofacial development of vertebrates, and thus has important biological functions. Here we compared the differences of maturation and target recognition between general microRNA and microRNA-140. Moreover, we reviewed the craniofacial development regulation of micro-RNA-140.%微小RNA-140是参与脊椎动物胚胎颌面部发育的分子之一,具有重要的生物学功能。本文比较了微小RNA-140在成熟和靶标识别方面相对于其他微小RNA的异同,并进一步就微小RNA-140对颌面部发育的调控作用作一综述。

  11. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.

    Science.gov (United States)

    Miller, Chris P; Shomali, Maysoun; Lyttle, C Richard; O'Dea, Louis St L; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R; Sahoo, Bishwabhusan; Kerrigan, Sean A; Burge, Matthew S; Nickels, Michael; Green, Jennifer L; Katzenellenbogen, John A; Tchesnokov, Alexei; Hattersley, Gary

    2011-02-10

    This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.

  12. The fine structure line deficit in S 140

    CERN Document Server

    Ossenkopf, Volker; Okada, Yoko; Mookerjea, Bhaswati; van der Tak, Floris F S; Simon, Robert; Pütz, Patrick; Güsten, Rolf

    2015-01-01

    We try to understand the gas heating and cooling in the S 140 star forming region by spatially and spectrally resolving the distribution of the main cooling lines with GREAT/SOFIA. We mapped the fine structure lines of [OI] (63 {\\mu}m) and [CII] (158 {\\mu}m) and the rotational transitions of CO 13-12 and 16-15 with GREAT/SOFIA and analyzed the spatial and velocity structure to assign the emission to individual heating sources. We measure the optical depth of the [CII] line and perform radiative transfer computations for all observed transitions. By comparing the line intensities with the far-infrared continuum we can assess the total cooling budget and measure the gas heating efficiency. The main emission of fine structure lines in S 140 stems from a 8.3'' region close to the infrared source IRS 2 that is not prominent at any other wavelength. It can be explained by a photon-dominated region (PDR) structure around the embedded cluster if we assume that the [OI] line intensity is reduced by a factor seven due ...

  13. A dysprosium-based metal-organic framework: Synthesis, characterization, crystal structure and interaction with calf thymus-DNA and bovine serum albumin

    Indian Academy of Sciences (India)

    Biplab Mondal; Buddhadeb Sen; Ennio Zangrando; Pabitra Chattopadhyay

    2014-07-01

    A dysprosium-based metallo-organic framework (MOF) containing calcium ions formulated as {Dy(pyda)3Ca1.5(H2O)6} · 5.5H2O (1) (H2pyda = pyridine-2,6-dicarboxylic acid) was solvothermally synthesized in ethanolic medium and characterized by physico-chemical and spectroscopic tools. A detailed structural analysis of the solid state structure of 1 by single crystal X-ray diffraction study showed a tricapped trigonal prism geometry for lanthanide in the [Dy(pyda)3]3− fragment. The mode of interaction of 1 with calf thymus- DNA and with protein bovine serum albumin (BSA) was investigated by using absorption and emission spectroscopic tools. The apparent association constant of complex 1 with CT-DNA was deduced from an absorption spectral study (b = 4.08 × 104 M-1). Spectral and viscosity measurements indicated a groove-binding mode of 1 with CT-DNA, and from spectroscopic study the formation of a metal complex-BSA adduct was assumed to be the result of the interaction of 1 with BSA.

  14. Dual-mode T1 and T2 magnetic resonance imaging contrast agent based on ultrasmall mixed gadolinium-dysprosium oxide nanoparticles: synthesis, characterization, and in vivo application

    Science.gov (United States)

    Tegafaw, Tirusew; Xu, Wenlong; Wasi Ahmad, Md; Baeck, Jong Su; Chang, Yongmin; Bae, Ji Eun; Chae, Kwon Seok; Kim, Tae Jeong; Lee, Gang Ho

    2015-09-01

    A new type of dual-mode T1 and T2 magnetic resonance imaging (MRI) contrast agent based on mixed lanthanide oxide nanoparticles was synthesized. Gd3+ (8S7/2) plays an important role in T1 MRI contrast agents because of its large electron spin magnetic moment resulting from its seven unpaired 4f-electrons, and Dy3+ (6H15/2) has the potential to be used in T2 MRI contrast agents because of its very large total electron magnetic moment: among lanthanide oxide nanoparticles, Dy2O3 nanoparticles have the largest magnetic moments at room temperature. Using these properties of Gd3+ and Dy3+ and their oxide nanoparticles, ultrasmall mixed gadolinium-dysprosium oxide (GDO) nanoparticles were synthesized and their potential to act as a dual-mode T1 and T2 MRI contrast agent was investigated in vitro and in vivo. The D-glucuronic acid coated GDO nanoparticles (davg = 1.0 nm) showed large r1 and r2 values (r2/r1 ≈ 6.6) and as a result clear dose-dependent contrast enhancements in R1 and R2 map images. Finally, the dual-mode imaging capability of the nanoparticles was confirmed by obtaining in vivo T1 and T2 MR images.

  15. Experimental and molecular dynamics studies of dysprosium(III) salt solutions for a better representation of the microscopic features used within the binding mean spherical approximation theory.

    Science.gov (United States)

    Ruas, Alexandre; Guilbaud, Philippe; Den Auwer, Christophe; Moulin, Christophe; Simonin, Jean-Pierre; Turq, Pierre; Moisy, Philippe

    2006-10-19

    This work is aimed at a predictive description of the thermodynamic properties of actinide(III) salt solutions at high concentration and 25 degrees C. A new solution of the binding mean spherical approximation (BIMSA) theory, based on the Wertheim formalism, for taking into account 1:1 and also 1:2 complex formation, is used to reproduce, from a simple procedure, experimental osmotic coefficient variation with concentration for three binary salt solutions of the same lanthanide(III) cation: dysprosium(III) perchlorate, nitrate, and chloride. The relevance of the fitted parameters is discussed, and their values are compared with available literature values. UV-vis/near-IR, time-resolved laser-induced fluorescence spectroscopy experiments, and molecular dynamics (MD) calculations were conducted for dilute to concentrated solutions (ca. 3 mol.kg-1) for a study of the microscopic behavior of DyCl3 binary solutions. Coupling MD calculations and extended X-ray absorption fine structure led to the determination of reliable distances. The MD results were used for a discussion of the parameters used in the BIMSA.

  16. Experimental and molecular dynamics studies of dysprosium(III) salt solutions for a better representation of the microscopic features used within the binding mean spherical approximation theory

    Energy Technology Data Exchange (ETDEWEB)

    Ruas, Alexandre; Guilbaud, Philippe; Den Auwer, Christophe; Moulin, Christophe; Simonin, Jean-Pierre; Turq, Pierre; Moisy, Philippe [DEN/DRCP/SCPS, CEA-Valrho Marcoule, BP 17171, 30207 Bagnols-sur-Ceze Cedex, DEN/DPC/SECR/LSRM, CEA-Saclay, Bat 391, BP 91191 Gif sur Yvette, Cedex (France); Laboratoire LI2C (UMR 7612), Universite Pierre et Marie Curie-Paris 6, Boite No. 51, 4 Place Jussieu, 75252 Paris Cedex 05 (France)

    2006-07-01

    This work is aimed at a predictive description of the thermodynamic properties of actinide (III) salt solutions at high concentration and 25 deg. C. A new solution of the binding mean spherical approximation (BIMSA) theory, based on the Wertheim formalism, for taking into account 1: 1 and also 1: 2 complex formation, is used to reproduce, from a simple procedure, experimental osmotic coefficient variation with concentration for three binary salt solutions of the same lanthanide (III) cation: dysprosium (III) perchlorate, nitrate, and chloride. The relevance of the fitted parameters is discussed, and their values are compared with available literature values. UV-vis/near-IR, time-resolved laser-induced fluorescence spectroscopy experiments, and molecular dynamics (MD) calculations were conducted for dilute to concentrated solutions (ca. 3 mol, kg{sup -1}) for a study of the microscopic behavior of DyCl{sub 3} binary solutions. Coupling MD calculations and extended X-ray absorption fine structure led to the determination of reliable distances. The MD results were used for a discussion of the parameters used in the BIMSA. (authors)

  17. Elucidation of Dual Magnetic Relaxation Processes in Dinuclear Dysprosium(III) Phthalocyaninato Triple-Decker Single-Molecule Magnets Depending on the Octacoordination Geometry.

    Science.gov (United States)

    Katoh, Keiichi; Aizawa, Yu; Morita, Takaumi; Breedlove, Brian K; Yamashita, Masahiro

    2017-08-07

    When applying single-molecule magnets (SMMs) to spintronic devices, control of the quantum tunneling of the magnetization (QTM) as well as a spin-lattice interactions are important. Attempts have been made to use not only coordination geometry but also magnetic interactions between SMMs as an exchange bias. In this manuscript, dinuclear dysprosium(III) (Dy(III) ) SMMs with the same octacoordination geometry undergo dual magnetic relaxation processes at low temperature. In the dinuclear Dy(III) phthalocyaninato (Pc(2-) ) triple-decker type complex [(Pc)Dy(ooPc)Dy(Pc)] (1) (ooPc(2-) =2,3,9,10,16,17,23,24-octakis(octyloxy)phthalocyaninato) with a square-antiprismatic (SAP) geometry, the ground state is divided by the Zeeman effect, and level intersection occurs when a magnetic field is applied. Due to the ground state properties of 1, since the Zeeman diagram where the levels intersect in an Hdc of 2500 Oe, two kinds of QTM and direct processes occur. However, dinuclear Dy(III) -Pc systems with C4 geometry, which have a twist angle (ϕ) of less than 45° do not undergo dual magnetic relaxation processes. From magnetic field and temperature dependences, the dual magnetic relaxation processes were clarified. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Annealing behaviour and crystal structure of RF-sputtered Bi-substituted dysprosium iron-garnet films having excess co-sputtered Bi-oxide content

    Energy Technology Data Exchange (ETDEWEB)

    Vasiliev, M; Nur-E-Alam, M; Alameh, K [Electron Science Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027 (Australia); Premchander, P; Lee, Y T [Department of Information and Communications, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712 (Korea, Republic of); Kotov, V A [Institute of Radio Engineering and Electronics, Russian Academy of Sciences, 11 Mohovaya St, Moscow, 125009 (Russian Federation); Lee, Y P, E-mail: m.vasiliev@ecu.edu.au [Quantum Photonic Science Research Center, Department of Physics, Hanyang University, 133-791 (Korea, Republic of)

    2011-02-23

    We investigate the magneto-optic properties, crystal structure and annealing behaviour of nano-composite media with record-high magneto-optic quality exceeding the levels reported so far in sputtered iron-garnet films. Bi-substituted dysprosium-gallium iron-garnet films having excess bismuth oxide content are deposited using RF co-sputtering, and a range of garnet materials are crystallized using conventional oven-annealing processes. We report, for the first time ever, the results of optimization of thermal processing regimes for various high-performance magneto-optic iron-garnet compositions synthesized and describe the evolution of the optical and magneto-optical properties of garnet-Bi-oxide composite-material films occurring during the annealing processes. The crystallization temperature boundaries of the system (BiDy){sub 3}(FeGa){sub 5}O{sub 12} : Bi{sub 2}O{sub 3} are presented. We also report the results of x-ray diffraction and energy-dispersive x-ray spectroscopy studies of this recently developed class of high-performance magneto-optic composites. Our hypothesis of iron oxides being the cause of excess optical absorption in sputtered Bi-iron-garnet films is confirmed experimentally.

  19. Bright-rimmed molecular cloud around S140 IRS. II. Bipolar outflow from S140 IRS 1

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, M.; Hasegawa, T.; Omodaka, T.; Hayashi, S.S.; Miyawaki, R.

    1987-01-01

    Radioastronomy maps are presented from 16 arcsec resolution scans of the C-12O J = 1 yields 0 emission from S140 IRS, an H II region that is also associated with star formation. The observed C-12O outflow exhibits clear bipolarity. Integral values are calculated for the total mass, momentum and energy of the outflow, which has a velocity asymmetry that features the lowest velocity in the region of greatest mass outflow. Possible explanations for the velocity/mass outflow asymmetry are considered. 37 references.

  20. 40 CFR 429.140 - Applicability; description of the particleboard manufacturing subcategory.

    Science.gov (United States)

    2010-07-01

    ... particleboard manufacturing subcategory. 429.140 Section 429.140 Protection of Environment ENVIRONMENTAL... CATEGORY Particleboard Manufacturing Subcategory § 429.140 Applicability; description of the particleboard manufacturing subcategory. This subpart applies to discharges to waters of the United States and to...

  1. 21 CFR 1404.140 - How do I know if a person is excluded?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false How do I know if a person is excluded? 1404.140 Section 1404.140 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1404.140 How do I know if a person is excluded? Check the...

  2. 75 FR 39273 - Energy Independence and Security Act (Pub. L. 110-140)

    Science.gov (United States)

    2010-07-08

    ....S. Geological Survey Energy Independence and Security Act (Pub. L. 110-140) AGENCY: U.S. Geological.... SUMMARY: In 2007, the Energy Independence and Security Act (Pub. L. 110-140) directed the United States... 711 of Public Law 110-140. Dated: June 28, 2010. Brenda Pierce, Chief Scientist (acting) and...

  3. 5 CFR 1201.140 - Judge; requirement for finding of good cause.

    Science.gov (United States)

    2010-01-01

    ... cause. 1201.140 Section 1201.140 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION... Administrative Law Judges § 1201.140 Judge; requirement for finding of good cause. (a) Judge. (1) An... part. (b) Requirement for finding of good cause. A decision on a proposed agency action under...

  4. 33 CFR 140.101 - Inspection by Coast Guard marine inspectors or Minerals Management Service inspectors.

    Science.gov (United States)

    2010-07-01

    ... inspectors or Minerals Management Service inspectors. 140.101 Section 140.101 Navigation and Navigable Waters... Inspections § 140.101 Inspection by Coast Guard marine inspectors or Minerals Management Service inspectors... Minerals Management Service (MMS). (c) Under the direction of the Officer in Charge, Marine Inspection...

  5. 17 CFR 1.40 - Crop, market information letters, reports; copies required.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Crop, market information letters, reports; copies required. 1.40 Section 1.40 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous § 1.40 Crop, market...

  6. Based on Brevity: Fiction in 140 Characters or Less

    Directory of Open Access Journals (Sweden)

    Ritika Singh

    2016-12-01

    Full Text Available This paper examines how short-short stories published on social media platforms such asFacebook and Twitter experiment with brevity. It examines the use of devices such as planned spaces between words, colors, and enjambments, a genre called twitter fiction, to deliver the literary after-taste of ‘byte-sized’ fiction. What are the ramifications, requirements, and results of this form of brevity? Since the works are written and published on/for the digital media, what other aids supplement the reading process, if any? What forms of innovation does this conciseness allow? Two platforms of reading and writing short-short stories (of 140 characters or less will be used to examine these questions: Terribly Tiny Tales on Facebook and Very Short Story (@veryshortstoryon Twitter. Keywords: digital humanities, twitter fiction, brevity, short story, technology, social mediaThe six-word story by Ernest Hemingway, written in the 1920s, can be seen as an exemplary precursor to the recent burgeoning of short-short stories on Twitter and Facebook. To clearly define the term in the context of length is a complicated process as not only do short-short stories have different names, there is no fixity in terms of how short they must be or which style or form they deal with – ranging from myths and fables to serialized novels. However, works that are strictly 140 characters or less come under the subset of short-short stories and are popularly known as ‘140 stories,’ ‘short-shorts,’ and ‘very short stories.’ These are mostly published on social platforms like Twitter, Facebook, Tumblr and personal blogs to allow immediacy in writing, self-publishing, and reaching out to an audience. Restricting the work to this minimum character limit allows the writer to publish the work across different social platforms.Therefore, the underlining requirement of this form of literature is that it must be brief. This becomes the first and the most important

  7. Utilidad de la mediastinoscopia: resultados de 140 procedimientos

    Directory of Open Access Journals (Sweden)

    José A Mainieri-Hidalgo

    2014-09-01

    Full Text Available Objetivo: determinar la sensibilidad y especificidad de la mediastinoscopia para diagnóstico y estadiaje de enfermedades del tórax. Método: se revisó la información general incluida en la base de datos del servicio de Cirugía de Tórax del Hospital Dr. R. Á. Calderón Guardia, de 140 pacientes sometidos a mediastinoscopia durante el periodo comprendido entre 1989 y 2013, la cual se complementó con datos específicos obtenidos de los expedientes clínicos. Resultados: se estudió 140 casos de mediastinoscopias, en 94 hombres y 46 mujeres con edad promedio de 55 años. En 136 se obtuvo muestra suficiente para establecer un diagnóstico histológico con una sensibilidad para el procedimiento del 97%; en 133 este fue específico del padecimiento del paciente, para una especificidad del 95%. La sensibilidad y especificidad para patologías primarias de los ganglios mediastinales, fueron ambas del 100%. Se produjo dos complicaciones: una lesión de la arteria pulmonar y otra de la vena ázigos, que fueron reparadas por esternotomía, para un porcentaje del 1,3%. No se presentó ningún caso de mortalidad, ni otras complicaciones. Conclusiones: se demostró que la mediastinoscopia es un procedimiento útil para diagnosticar enfermedades del tórax cuando involucran los ganglios que son accesibles, lo cual puede determinarse con la TAC, y cuando es realizada por un cirujano con experiencia, el porcentaje de complicaciones es muy bajo.

  8. Global use structures of the magnetic materials neodymium and dysprosium. A scenario-based analysis of the effect of the diffusion of electromobility on the demand for rare earths; Globale Verwendungsstrukturen der Magnetwerkstoffe Neodym und Dysprosium. Eine szenariobasierte Analyse der Auswirkung der Diffusion der Elektromobilitaet auf den Bedarf an Seltenen Erden

    Energy Technology Data Exchange (ETDEWEB)

    Gloeser-Chahoud, Simon; Kuehn, Andre; Tercero Espinoza, Luis

    2016-06-15

    Neodymium-iron-boron magnets (NdFeB) have experienced a significant demand as the most powerful permanent magnet in recent years, especially for the manufacture of compact electric servomotors with high efficiency and high power density, especially for mobile applications in hybrid traction motors and electric vehicles or for electric bikes. However, NdFeB magnets are also increasingly being used in general mechanical engineering (conveying and pumping systems, tools, air conditioning systems, lift motors, etc.), in the small electric motors of conventional passenger cars or in the generators of large wind power plants with permanent magnetic direct drive. Nevertheless, there is still high uncertainty in the use structures of NdFeB magnets and the contained rare earth elements neodymium and dysprosium. An effective instrument for increasing the market transparency and the understanding of complex anthropogenic material cycles is the dynamic material flow modeling. In the present work paper, this instrument is used for an in-depth analysis of the use structures of NdFeB magnets and the contained rare earths on a global scale. The dynamic modeling of product usage cycles reveals today's usage structures and quantifies future magnetic quantities in obsolete product flows. It could be shown that the magnets in today's scrap volume are mainly contained in obsolete electronics applications such as hard disks (HDD), CD and DVD drives, which makes the recycling hardly seem to be economical due to the small magnets and the high material spread, but in the foreseeable future with larger magnetic quantities from synchronous servomotors and generators can be expected, which significantly increases the recycling potential. In a further step, the effect of the diffusion of alternative drives in the automotive market on the dysprosium requirement is analyzed using a system dynamics model and possible adaptation mechanisms in the form of different substitution effects in

  9. The role of dysprosium on the structural and magnetic properties of (Nd1-xDyx)2Fe14B nanoparticles

    Science.gov (United States)

    Rahimi, Hamed; Ghasemi, Ali; Mozaffarinia, Reza; Tavoosi, Majid

    2017-02-01

    In current work, Nd2Fe14B nanoparticles was synthesized by sol-gel method. Dysprosium powders were added into Nd2Fe14B nanoparticles by mechanical alloying process in order to enhancement of coercivity. The phase analysis, structure, and magnetic properties of annealed (Nd1-xDyx)2Fe14B nanoparticles with different Dy-content (x=0.1, 0.2, 0.3, 0.4, 0.5, 0.6) were investigated by employing X-ray diffraction, X-ray photoelectron spectroscopy, energy dispersive spectroscopy, field emission scanning electron microscope, transmission electron microscope and vibrating sample magnetometer techniques. The results showed that with an increase in Dy amounts, the coercivity of particles increased from 2.9 kOe to 13.4 kOe and then decreased to 5.6 kOe. By adding an optimum amount of Dy (x=0.4), the coercivity was significantly increased from 2.9 kOe to 13.4 kOe. The average particle size of annealed (Nd1-xDyx)2Fe14B nanoparticles was below 10 nm. Magnetization reversal studies indicate that the coercivity of milled and annealed (Nd1-xDyx)2Fe14B nanoparticles is controlled by the nucleation of reversed magnetic domains. The experimental results in the angular dependence of coercivity for (Nd1-xDyx)2Fe14B permanent magnets showed that the normalized coercivity of the permanent magnets Hc(θ)/Hc(0) increases from 1 to about 1.2-1.5 with increasing θ from 0 to about π/3, for x=0.4-0.6.

  10. Temperatures of dust and gas in S~140

    CERN Document Server

    Koumpia, E; Ossenkopf, V; van der Tak, F F S; Mookerjea, B; Fuente, A; Kramer, C

    2015-01-01

    In dense parts of interstellar clouds (> 10^5 cm^-3), dust & gas are expected to be in thermal equilibrium, being coupled via collisions. However, previous studies have shown that the temperatures of the dust & gas may remain decoupled even at higher densities. We study in detail the temperatures of dust & gas in the photon-dominated region S 140, especially around the deeply embedded infrared sources IRS 1-3 and at the ionization front. We derive the dust temperature and column density by combining Herschel PACS continuum observations with SOFIA observations at 37 $\\mu$m and SCUBA at 450 $\\mu$m. We model these observations using greybody fits and the DUSTY radiative transfer code. For the gas part we use RADEX to model the CO 1-0, CO 2-1, 13CO 1-0 and C18O 1-0 emission lines mapped with the IRAM-30m over a 4' field. Around IRS 1-3, we use HIFI observations of single-points and cuts in CO 9-8, 13CO 10-9 and C18O 9-8 to constrain the amount of warm gas, using the best fitting dust model derived wit...

  11. Role of Receptor-Interacting Protein 140 in human fat cells

    Directory of Open Access Journals (Sweden)

    Stenson Britta M

    2010-01-01

    Full Text Available Abstract Background Mice lacking Receptor-interacting protein 140 (RIP140 have reduced body fat which at least partly is mediated through increased lipid and glucose metabolism in adipose tissue. In humans, RIP140 is lower expressed in visceral white adipose tissue (WAT of obese versus lean subjects. We investigated the role of RIP140 in human subcutaneous WAT, which is the major fat depot of the body. Methods Messenger RNA levels of RIP140 were measured in samples of subcutaneous WAT from women with a wide variation in BMI and in different human WAT preparations. RIP140 mRNA was knocked down with siRNA in in vitro differentiated adipocytes and the impact on glucose transport and mRNA levels of target genes determined. Results RIP140 mRNA levels in subcutaneous WAT were decreased among obese compared to lean women and increased by weight-loss, but did not associate with mitochondrial DNA copy number. RIP140 expression increased during adipocyte differentiation in vitro and was higher in isolated adipocytes compared to corresponding pieces of WAT. Knock down of RIP140 increased basal glucose transport and mRNA levels of glucose transporter 4 and uncoupling protein-1. Conclusions Human RIP140 inhibits glucose uptake and the expression of genes promoting energy expenditure in the same fashion as the murine orthologue. Increased levels of human RIP140 in subcutaneous WAT of lean subjects may contribute to economize on energy stores. By contrast, the function and expression pattern does not support that RIP140 regulate human obesity.

  12. Investigation Solvation Dynamics and Isomerization of Dye IR-140 Using pump supercontinuum-probing Technique

    CERN Document Server

    Wang, D; Wu, S; Yang, H; Xiang, Q G J; Xu, G; Wang, Danling; Jiang, Hongbing; Wu, Songjiang; Yang, Hong; Xiang, Qihuang Gong Junfeng; Xu, Guangzhi

    2001-01-01

    The solvation dynamics and isomerization process of an organic dye, IR-140, in polar solvents and nonpolar solvents have been investigated using pump supercontinuum-probing (PSCP) technique. In all solvents, the dynamics exhibits solvent-dependent. Solvent induced spectral shifts of the absorption and emission spectra of IR-140 have also been studied in a variety of solvents. At the same time, the photoisomerization process has been examined. The approximate energy-band structure of IR-140 was also supposed firstly.

  13. PRO140:a MAB HIV Entry Inhibitor%单克隆抗体HIV进入抑制剂PRO140

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    HIV病毒株可分为R5嗜性和X4嗜性,它们分别通过趋化因子CCR5和CXCR4辅助受体进入CD4细胞。在HIV的整个发展进程中,可常发生其病毒株由R5嗜性转型为X4嗜性,且也有可能某个体同时被R5嗜性和X4嗜性病毒感染,而CCR5拮抗剂则对x4嗜性病毒无效。由Progenics制药公司开发的用于治疗HIV感染的人源化单克隆抗体CCR5拮抗剂PRO140为一种新型HIV进人抑制剂,可与CCR5受体的特殊区段紧密结合,对CCR5产生拮抗作用,从而抑制HIV通过这一辅助受体进入靶细胞;

  14. 76 FR 63282 - Foreign-Trade Zone 140-Flint, Michigan; Application for Subzone; Hemlock Semiconductor...

    Science.gov (United States)

    2011-10-12

    ... Zone 140--Flint, Michigan; Application for Subzone; Hemlock Semiconductor Corporation (Polysilicon... facility of Hemlock Semiconductor Corporation (HSC), located in Hemlock, Michigan. The application...

  15. [Meralgia paraesthetica: a report on a series of 140 cases].

    Science.gov (United States)

    Martínez-Salio, A; Moreno-Ramos, T; Díaz-Sánchez, M; Porta-Etessam, J; González de la Aleja, J; Gutiérrez-Gutiérrez, G; Calandre-Hoenigsfeld, L

    Meralgia paraesthetica is a pathology that is frequently seen in visits to extra-hospital neurology services. Nevertheless, the diagnosis, treatment and prognosis of this condition remain somewhat unclear. A retrospective study was conducted involving 140 patients. Data were collected concerning demographic aspects, clinical picture, diagnostic study, aetiology, treatment and progression. There was a predominance of males, with a mean age of 54 years. The mean follow-up time was 25 months. The symptoms that were reported were as follows: numbness, burning pain, tingling or prickling in the nerve territory. Hypaesthesia was the most frequent sign found in the examination. History of another compressive neuropathy was present in 13.6% of patients. The diagnosis was based on the patient record and the neurological examination. The neurophysiological study and complementary tests were reserved for atypical cases. The most common causation was spontaneous and only three cases were found to be secondary to a structural lesion. A third of the patients were receiving pharmacological treatment. Although the clinical picture was benign, in most cases it tended to become chronic. Patients treated pharmacologically did not show a significant improvement in comparison to those who were not given treatment. The most important data for forecasting improvement of the clinical picture were the identification and correction of the factors precipitating compression of the nerve. Meralgia paraesthetica is a frequent, benign pathology but with a tendency to become chronic that responds poorly to pharmacological treatment. It is important to identify and correct mechanical factors and only in exceptional cases is it secondary to a structural lesion.

  16. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.

    Science.gov (United States)

    Davis, B M; Roth, J C; Liu, L; Xu-Welliver, M; Pegg, A E; Gerson, S L

    1999-11-20

    The G156A O6-alkylguanine-DNA alkyltransferase (AGT) mutant protein, encoded by the G156A O6-methylguanine-DNA methyltransferase gene (MGMT), is resistant to O6-benzylguanine (BG) inactivation and, after transduction into hematopoietic progenitors, transmits remarkable resistance to BG and BCNU. As a result, a clinical trial, in which the MGMT gene is transduced into CD34+ cells of patients with cancer, has been approved. A newly identified AGT mutation, P140K, generates dramatically increased BG resistance relative to G156A, and suggests that gene transfer of P140K may confer improved hematopoietic cell protection. To address this hypothesis, we measured BG + BCNU and BG + TMZ resistance in G156A, P140K, or P138M/V139L/P140K (MLK) MGMT-transduced K562 cells. In addition, we performed a detailed characterization of individual properties including BG resistance, activity, and protein stability of these mutants in human hematopoetic K562 cells and E86 retroviral producer cells. In K562 cell extracts, the MLK and P140K mutants retained full activity at doses up to 1 mM BG, while G156A had a BG ED50 of 15 microM, compared with 0.1 microM for wtAGT. In the absence of BG, the G156A protein possessed a 56% reduction in specific O6-methyltransferase activity compared with wtAGT. MLK, P140K, and wtAGT all possessed similar specific activities, although the O6-methyl repair rate of all mutants was reduced 4- to 13-fold relative to wtAGT. The wtAGT, MLK, and P140K proteins were stable, with half-lives of greater than 18 hr. In contrast, only 20% of the G156A protein was stable after 12 hr in cycloheximide and, interestingly, the remaining protein appeared to retain most of the activity present in non-cycloheximide-treated cells. Differences in BG resistance, activity, and stability between P140K, MLK, and G156A suggest that P140K may be the optimal mutant for drug resistance gene transfer. However, hematopoietic K562 cells transduced with MFG-G156A, P140K, or MLK had similar

  17. Dysprosium(III) complexes with a square-antiprism configuration featuring mononuclear single-molecule magnetic behaviours based on different β-diketonate ligands and auxiliary ligands.

    Science.gov (United States)

    Zhang, Sheng; Ke, Hongshan; Shi, Quan; Zhang, Jangwei; Yang, Qi; Wei, Qing; Xie, Gang; Wang, Wenyuan; Yang, Desuo; Chen, Sanping

    2016-03-28

    Three mononuclear dysprosium(III) complexes derived from three β-diketonate ligands, 4,4,4-trifluoro-1-(4-methylphenyl)-1,3-butanedione (tfmb), 4,4,4-trifluoro-1-(4-fluorophenyl)-1,3-butanedione (tffb) and 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedione (tfnb) as well as auxiliary ligands, 5-nitro-1,10-phenanthroline (5-NO2-Phen), DMF and 2,2'-bipyridine (bpy) have been synthesized and structurally characterized, namely [Dy(5-NO2-Phen)(tfmb)3] (1), [Dy(DMF)2(tffb)3] (2) and [Dy(bpy)2(tfnb)3]·0.5(1,4-dioxane) (3). The metal ions in 1-3 adopt an approximately square-antiprismatic (SAP) coordination environment with D4d axial symmetry. The magnetic properties of 1-3 have been investigated, displaying weak out-of-phase AC signals under a zero-DC field. With an applied DC field of 1200 Oe, the quantum tunnelling of the magnetization was suppressed in 1-3 with the pre-exponential factor τ0 = 5.3 × 10(-7) s and the effective barrier ΔE/kB = 83 K for 1 as well as the pre-exponential factor τ0 = 3.09 × 10(-7) s and the effective barrier ΔE/kB = 39 K for 3. Interestingly, for the frequency dependence of the out-of-phase (χ'') of the AC susceptibility of 2, two slow relaxation of the magnetization processes occurred under the applied magnetic field of 1200 Oe, corresponding to the fast relaxation (FR) phase and slow relaxation (SR) phase, respectively. Arrhenius analysis gave the effective energy barrier (ΔE/kB) of 55 K and the pre-exponential factor (τ0) of 8.23 × 10(-12) for the SR. It is thus very likely that the FR process in complex 2 results from QTM enhanced by dipolar interactions between the Dy ions or the presence of the applied field. The structure-property relationship of some Dy(III) based mononuclear SMMs with the SAP configuration was further discussed.

  18. Magnetic Phase Transition of Nanocrystalline Bulk Metal Gadolinium and Dysprosium%纳米块体金属钆和镝的磁性相变分析

    Institute of Scientific and Technical Information of China (English)

    刘凤艳; 侯碧辉; 岳明; 王克军

    2011-01-01

    The magnetic properties of bulk nanocrystalline metal gadolinium (Gd) and dysprosium (Dy)samples were studied.The magnetization and Curie temperature TC of nanocrystalline Gd and Dy decreased usually as compared with the polycrystal.However,when the mean grain size was 10 nm, the Curie temperature Tc of nanocrystalline Dy increased to 100 K instead and there was an antiferromagnetic phase in nanocrystalline Gd.According to the calculation based on Ruderman-Kittel-Kasuya-Yosida exchange interaction, the exchange integral of the grain boundary atoms and crystalline surface atoms had its sign changed from plus to minus or vice versa, and there were three orderly phases in the steady state with the lowest energy, ferromagnetic phase, antiferromagnetic phase and fan phase.For the nanocrystals with mean grain size of 10 nm, the proportion of grain boundary to crystalline surface atoms was high, and as the result of superposition of the three phases, and there appeared a peak near the phase transition temperature for the nanocrystalline Gd.While for the Dy, the magnetization decreased gently with temperature, and showing a higher Curie temperature than in the case of the polycrystal.%对纳米晶钆(Gd)和镝(Dy)块体材料的磁性进行了研究.与多晶比较,通常纳米晶的磁化强度减小,居里温度TC降低,但平均粒径为10 nm的纳米晶Dy的居里温度TC反而升高到100 K,平均粒径为10 nm的纳米晶Gd中还存在明显的反铁磁相.通过RKKY交换作用的计算知道,晶面晶界处原子的交换积分会发生正负号的变化,能量最低的稳定状态对应三种有序相:铁磁相、反铁磁相和扇相,晶粒中在一定条件下出现三相共存.对于平均粒径为10 nm的纳米晶,晶面晶界处原子所占比例很大,三相叠加的结果,对于Gd,即是在相变点附近出现磁化强度尖峰;对于Dy,则是磁化强度随温度升高下降缓慢,表现为居里温度TC比多晶升高.

  19. 10 CFR 140.91 - Appendix A-Form of nuclear energy liability policy for facilities.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Appendix A-Form of nuclear energy liability policy for facilities. 140.91 Section 140.91 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION... other matter not within the Commission's statutory jurisdiction under the Atomic Energy Act....

  20. 20 CFR 404.140 - What is a quarter of coverage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What is a quarter of coverage. 404.140... DISABILITY INSURANCE (1950- ) Insured Status and Quarters of Coverage Quarters of Coverage § 404.140 What is a quarter of coverage. (a) General. A quarter of coverage (QC) is the basic unit of social...

  1. 45 CFR 286.140 - What special provisions apply to victims of domestic violence?

    Science.gov (United States)

    2010-10-01

    ... domestic violence? 286.140 Section 286.140 Public Welfare Regulations Relating to Public Welfare OFFICE OF... special provisions apply to victims of domestic violence? (a) Tribes electing the Family Violence Option... and identify individuals receiving TANF assistance with a history of domestic violence,...

  2. 40 CFR 436.140 - Applicability; description of the potash subcategory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Applicability; description of the potash subcategory. 436.140 Section 436.140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY...

  3. 42 CFR 433.140 - FFP and repayment of Federal share.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false FFP and repayment of Federal share. 433.140 Section....140 FFP and repayment of Federal share. (a) FFP is not available in Medicaid payments if— (1) The... insurance contract limits or excludes payments if the individual is eligible for Medicaid. (b) FFP...

  4. 77 FR 65706 - Agency Information Collection Activities: Immigrant Petition for Alien Worker, Form I-140...

    Science.gov (United States)

    2012-10-30

    ... Petition for Alien Worker, Form I-140; Revision of a Currently Approved Collection ACTION: 60-Day Notice... Form/Collection: Immigrant Petition for Alien Worker. (3) Agency form number, if any, and the... information furnished on Form I-140 will be used by USCIS to classify aliens under sections 203(b)(1),...

  5. 77 FR 52692 - NIST Federal Information Processing Standard (FIPS) 140-3 (Second Draft), Security Requirements...

    Science.gov (United States)

    2012-08-30

    ... National Institute of Standards and Technology NIST Federal Information Processing Standard (FIPS) 140-3... sections of Federal Information Processing Standard 140-3 (Second Draft), Security Requirements for... may be sent to: Chief, Computer Security Division, Information Technology Laboratory, Attention:...

  6. Production and mechanical properties of aligned multi-walled carbon nanotubes-M140 composites

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This study investigated the production of M140, aligned multi-walled carbon nanotubes (A-MWNTs) reinforced M140 composites (A-MWNTs-M140) and their mechanical properties including their compressive and bending properties as well as their microstructure characteristic of bend fracture surface. M140 was first produced by speed change mixing technics with commercial materials, water-bath curing at normal temperature. In addition, two different A-MWNTs dispersions including carbonyl disper- sions of A-MWNTs (C-A-MWNTs) and aqueous dispersions of A-MWNTs (A-A-MWNTs) with the addition of 0.01wt% A-MWNTs were utilized to obtain enhanced mechanical properties with respect to plain M140. The results indicated that the use of A-MWNTs dispersions allows increasing compressive strength and flexural strength by 8.4% and 5.4%, respectively for the C-A-MWNTs-M140, and by 15.9% and 20.7% for the A-A-MWNTs-M140, respectively. The SEM and EPMA examinations of fracture surface also showed that the bond interface between the nanotubes and matrix is moderate and the main reinforcing mechanisms are microfilling effect, CNTs pull-out and debond. The aqueous dispersion of A-MWNTs is an appropriate method and is more compatible with the M140.

  7. Production and mechanical properties of aligned multi-walled carbon nanotubes-M140 composites

    Institute of Scientific and Technical Information of China (English)

    XU ShiLang; GAO LiangLi; JIN WeiJun

    2009-01-01

    This study investigated the production of M140, aligned multi-walled carbon nanotubes (A-MWNTs)reinforced M140 composites (A-MWNTs-M140) and their mechanical properties including their compressive and bending properties as well as their microstructure characteristic of bend fracture surface.M140 was first produced by speed change mixing technics with commercial materials, water-bath curing at normal temperature. In addition, two different A-MWNTs dispersions including carbonyl dispersions of A-MWNTs (C-A-MWNTs) and aqueous dispersions of A-MWNTs (A-A-MWNTs) with the addition of 0.01wt% A-MWNTs were utilized to obtain enhanced mechanical properties with respect to plain M140. The results indicated that the use of A-MWNTs dispersions allows increasing compressive strength and flexural strength by 8.4% and 5.4%, respectively for the C-A-MWNTs-M140, and by 15.9% and 20.7% for the A-A-MWNTs-M140, respectively. The SEM and EPMA examinations of fracture surface also showed that the bond interface between the nanotubes and matrix is moderate and the main reinforcing mechanisms are microfilling effect, CNTs pull-out and debond. The aqueous dispersion of A-MWNTs is an appropriate method and is more compatible with the M140.

  8. 40 CFR 1048.140 - What are the provisions for certifying Blue Sky Series engines?

    Science.gov (United States)

    2010-07-01

    ... Blue Sky Series engines? 1048.140 Section 1048.140 Protection of Environment ENVIRONMENTAL PROTECTION... Sky Series engines? This section defines voluntary standards for a recognized level of superior emission control for engines designated as “Blue Sky Series” engines. If you certify an engine family...

  9. Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis.

    LENUS (Irish Health Repository)

    Gunawardena, H

    2009-06-01

    OBJECTIVE: The identification of novel autoantibodies in juvenile dermatomyositis (DM) may have etiologic and clinical implications. The aim of this study was to describe autoantibodies to a 140-kd protein in children recruited to the Juvenile DM National Registry and Repository for UK and Ireland. METHODS: Clinical data and sera were collected from children with juvenile myositis. Sera that recognized a 140-kd protein by immunoprecipitation were identified. The identity of the p140 autoantigen was investigated by immunoprecipitation\\/immunodepletion, using commercial monoclonal antibodies to NXP-2, reference anti-p140, and anti-p155\\/140, the other autoantibody recently described in juvenile DM. DNA samples from 100 Caucasian children with myositis were genotyped for HLA class II haplotype associations and compared with those from 864 randomly selected UK Caucasian control subjects. RESULTS: Sera from 37 (23%) of 162 patients with juvenile myositis were positive for anti-p140 autoantibodies, which were detected exclusively in patients with juvenile DM and not in patients with juvenile DM-overlap syndrome or control subjects. No anti-p140 antibody-positive patients were positive for other recognized autoantibodies. Immunodepletion suggested that the identity of p140 was consistent with NXP-2 (the previously identified MJ autoantigen). In children with anti-p140 antibodies, the association with calcinosis was significant compared with the rest of the cohort (corrected P < 0.005, odds ratio 7.0, 95% confidence interval 3.0-16.1). The clinical features of patients with anti-p140 autoantibodies were different from those of children with anti-p155\\/140 autoantibodies. The presence of HLA-DRB1*08 was a possible risk factor for anti-p140 autoantibody positivity. CONCLUSION: This study has established that anti-p140 autoantibodies represent a major autoantibody subset in juvenile DM. This specificity may identify a further immunogenetic and clinical phenotype within the

  10. Extension of the energy range of the experimental activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium up to 65 MeV

    CERN Document Server

    Tárkányi, F; Takács, S; Hermanne, A; Ignatyuk, A V

    2016-01-01

    Activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium were extended up to 65 MeV by using stacked foil irradiation and gamma spectrometry experimental methods. Experimental cross-sections data for the formation of the radionuclides $^{159}$Dy, $^{157}$Dy, $^{155}$Dy, $^{161}$Tb, $^{160}$Tb, $^{156}$Tb, $^{155}$Tb, $^{154m2}$Tb, $^{154m1}$Tb, $^{154g}$Tb, $^{153}$Tb, $^{152}$Tb and $^{151}$Tb are reported in the 36-65 MeV energy range, and compared with an old dataset from 1964. The experimental data were also compared with the results of cross section calculations of the ALICE and EMPIRE nuclear model codes and of the TALYS nuclear reaction model code as listed in the latest on-line libraries TENDL 2013.

  11. Extension of the energy range of the experimental activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium up to 65MeV.

    Science.gov (United States)

    Tárkányi, F; Ditrói, F; Takács, S; Hermanne, A; Ignatyuk, A V

    2015-04-01

    Activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium were extended up to 65MeV by using stacked foil irradiation and gamma spectrometry experimental methods. Experimental cross-sections data for the formation of the radionuclides (159)Dy, (157)Dy, (155)Dy, (161)Tb, (160)Tb, (156)Tb, (155)Tb, (154m2)Tb, (154m1)Tb, (154g)Tb, (153)Tb, (152)Tb and (151)Tb are reported in the 36-65MeV energy range, and compared with an old dataset from 1964. The experimental data were also compared with the results of cross section calculations of the ALICE and EMPIRE nuclear model codes and of the TALYS nuclear reaction model code as listed in the latest on-line libraries TENDL 2013. Copyright © 2015. Published by Elsevier Ltd.

  12. Determination of {sup 140}La fission product interference factor for INAA

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro Jr, Iberê S.; Genezini, Frederico A.; Saiki, Mitiko; Zahn, Guilherme S. [Instituto de Pesquisas Energéticas e Nucleares, IPEN/CNEN-SP, São Paulo - SP (Brazil)

    2014-11-11

    Instrumental Neutron Activation Analysis (INAA) is a technique widely used to determine the concentration of several elements in several kinds of matrices. However if the sample of interest has higher relative uranium concentration the obtained results can be interfered by the uranium fission products. One of these cases that is affected by interference due to U fission is the {sup 140}La, because this radioisotope used in INAA for the determination of concentration the La is also produced by the {sup −}β of {sup 140}Ba, an uranium fission product. The {sup 140}La interference factor was studied in this work and a factor to describe its time dependence was obtained.

  13. Airside HVAC BESTEST: HVAC Air-Distribution System Model Test Cases for ASHRAE Standard 140

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, Ronald [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Neymark, Joel [J. Neymark & Associates; Kennedy, Mike D. [Mike D. Kennedy, Inc.; Gall, J. [AAON, Inc.; Henninger, R. [GARD Analytics, Inc.; Hong, T. [Lawrence Berkeley National Laboratory; Knebel, D. [AAON, Inc.; McDowell, T. [Thermal Energy System Specialists, LLC; Witte, M. [GARD Analytics, Inc.

    2017-08-07

    This paper summarizes recent work to develop new airside HVAC equipment model analytical verification test cases for ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs. The analytical verification test method allows comparison of simulation results from a wide variety of building energy simulation programs with quasi-analytical solutions, further described below. Standard 140 is widely cited for evaluating software for use with performance-path energy efficiency analysis, in conjunction with well-known energy-efficiency standards including ASHRAE Standard 90.1, the International Energy Conservation Code, and other international standards. Airside HVAC Equipment is a common area of modelling not previously explicitly tested by Standard 140. Integration of the completed test suite into Standard 140 is in progress.

  14. Fire and EMS Districts, Fruitland140, Published in 2001, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Fire and EMS Districts dataset, was produced all or in part from Other information as of 2001. It is described as 'Fruitland140'. Data by this publisher are...

  15. 33 CFR 169.140 - What information must be included in the report?

    Science.gov (United States)

    2010-07-01

    ... Mandatory Ship Reporting Systems for the Protection of Northern Right Whales § 169.140 What information must be included in the report? Each ship report made to the shore-based authority must follow...

  16. Amorphous Aggregation of Amyloid Beta 1-40 Peptide in Confined Space.

    Science.gov (United States)

    Foschi, Giulia; Albonetti, Cristiano; Liscio, Fabiola; Milita, Silvia; Greco, Pierpaolo; Biscarini, Fabio

    2015-11-16

    The amorphous aggregation of Aβ1-40 peptide is addressed by using micromolding in capillaries. Both the morphology and the size of the aggregates are modulated by changing the contact angle of the sub-micrometric channel walls. Upon decreasing the hydrophilicity of the channels, the aggregates change their morphology from small aligned drops to discontinuous lines, thereby keeping their amorphous structure. Aβ1-40 fibrils are observed at high contact angles.

  17. Roles of micro RNA-140 in stem cell-associated early stage breast cancer

    Institute of Scientific and Technical Information of China (English)

    Benjamin; Wolfson; Gabriel; Eades; Qun; Zhou

    2014-01-01

    An increasing body of evidence supports a stepwise model for progression of breast cancer from ductal carcinoma in situ(DCIS) to invasive ductal carcinoma(IDC). Due to the high level of DCIS heterogeneity, we cannot currently predict which patients are at highest risk for disease recurrence or progression. The mechanisms of progression are still largely unknown, however cancer stem cell populations in DCIS lesions may serve as malignant precursor cells intimately involved in progression. While genetic and epigenetic alterations found in DCIS are often shared by IDC, m RNA and mi RNA expression profiles are significantly altered. Therapeutic targeting of cancer stem cell pathways and differentially expressed mi RNA could have significant clinical benefit. As tumor grade increases, mi RNA-140 is progressively downregulated. mi R-140 plays an important tumor suppressive role in the Wnt, SOX2 and SOX9 stem cell regulator pathways. Downregulation of mi R-140 removes inhibition of these pathways, leading to higher cancer stem cell populations and breast cancer progression. mi R-140 downregulation is mediated through both an estrogen response element in the mi R-140 promoter region and differential methylation of Cp G islands. These mechanisms are novel targets for epigenetic therapy to activate tumor suppressor signaling via mi R-140. Additionally, we briefly explored the emerging role of exosomes in mediating intercellular mi R-140 signaling. The purpose of this review is to examine the cancer stem cell signaling pathways involved in breast cancer progression, and the role of dysregulation of mi R-140 in regulating DCIS to IDC transition.

  18. Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.

    Science.gov (United States)

    Zucchelli, Chiara; Tamburri, Simone; Quilici, Giacomo; Palagano, Eleonora; Berardi, Andrea; Saare, Mario; Peterson, Pärt; Bachi, Angela; Musco, Giovanna

    2014-01-01

    Sp140 is a nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. The presence of several chromatin related modules such as plant homeodomain (PHD), bromodomain and SAND domain suggests a role in chromatin-mediated regulation of gene expression; however, its real function is still elusive. Herein we present the solution structure of Sp140-PHD finger and investigate its role as epigenetic reader in vitro. Sp140-PHD presents an atypical PHD finger fold which does not bind to histone H3 tails but is recognized by peptidylprolyl isomerase Pin1. Pin1 specifically binds to a phosphopeptide corresponding to the L3 loop of Sp140-PHD and catalyzes cis-trans isomerization of a pThr-Pro bond. Moreover co-immunoprecipitation experiments demonstrate FLAG-Sp140 interaction with endogenous Pin1 in vivo. Overall these data include Sp140 in the list of the increasing number of Pin1 binders and expand the regulatory potential of PHD fingers as versatile structural platforms for diversified interactions. © 2013 FEBS.

  19. Sequential administration of the high affinity CXCR4 antagonist BKT140 promotes megakaryopoiesis and platelet production.

    Science.gov (United States)

    Abraham, Michal; Weiss, Ido D; Wald, Hanna; Wald, Ori; Nagler, Arnon; Beider, Katia; Eizenberg, Orly; Peled, Amnon

    2013-10-01

    Platelets are the terminal differentiation product of megakaryocytes (MKs). Cytokines, such as thrombopoietin (TPO), are known to influence different steps in MK development; however, the complex differentiation and platelet localization processes are not fully understood. MKs express the receptor CXCR4 and have been shown to migrate in response to CXCL12 and to increase their platelet production. In this study, we studied the role of CXCR4 in platelet production with the high affinity CXCR4 antagonist, BKT140. Single and sequential administration of BKT140 significantly increased the number of MKs and haematopoietic progenitors (HPCs) within the bone marrow (BM). Increased megakaryopoiesis was associated with increased platelet production. Single and sequential administration of BKT140 also increased the number of HPCs in the blood. In a model of 5-fluorouracil-induced thrombocytopenia, BKT140 significantly reduced the severity and duration of thrombocytopenia and cytopenia when administered before and after chemotherapy. Our results demonstrated that the CXCR4 antagonist, BKT140, mediated unique beneficial effects by stimulating megakaryopoiesis and platelet production. These results provide evidence for the possible therapeutic use of BKT140 for modulating platelet numbers in thrombocytopenic conditions. © 2013 John Wiley & Sons Ltd.

  20. Dysprosium selective potentiometric membrane sensor

    Energy Technology Data Exchange (ETDEWEB)

    Zamani, Hassan Ali, E-mail: haszamani@yahoo.com [Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad (Iran, Islamic Republic of); Faridbod, Farnoush; Ganjali, Mohammad Reza [Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran (Iran, Islamic Republic of)

    2013-03-01

    A novel Dy(III) ion-selective PVC membrane sensor was made using a new synthesized organic compound, 3,4-diamino-N Prime -((pyridin-2-yl)methylene)benzohydrazide (L) as an excellent sensing element. The electrode showed a Nernstian slope of 19.8 {+-} 0.6 mV per decade in a wide concentration range of 1.0 Multiplication-Sign 10{sup -6}-1.0 Multiplication-Sign 10{sup -2} mol L{sup -1}, a detection limit of 5.5 Multiplication-Sign 10{sup -7} mol L{sup -1}, a short conditioning time, a fast response time (< 10 s), and high selectivity towards Dy(III) ion in contrast to other cations. The proposed sensor was successfully used as an indicator electrode in the potentiometric titration of Dy(III) ions with EDTA. The membrane sensor was also applied to the F{sup -} ion indirect determination of some mouth washing solutions and to the Dy{sup 3+} determination in binary mixtures. Highlights: Black-Right-Pointing-Pointer The novelty of this work is based on the high affinity of the ionophore toward the Dy{sup 3+} ions. Black-Right-Pointing-Pointer This technique is very simple, fast and inexpensive and it is not necessary to use sophisticated equipment. Black-Right-Pointing-Pointer The newly developed sensor is superior to the formerly reported Dy{sup 3+} sensors in terms of selectivity.

  1. The magnetocaloric effect in dysprosium

    Science.gov (United States)

    Benford, S. M.

    1979-01-01

    The magnetocaloric effect in polycrystalline Dy was measured in the 84-280-K range in measuring fields from 1 to 7 T. These adiabatic temperature changes reflect structural changes in Dy with applied field and temperature, and include the first magnetocaloric data for a helical antiferromagnet. Above the Neel point (179 K) a field increase always caused heating; below the Neel point fields less than about 2 T cause cooling for some values of initial temperature. The largest temperature increase with a 7 T field occurs at the Neel point and at fields below 2 T near the Curie point. For refrigeration purposes the optimal working region for a Dy cooling element is field dependent.

  2. 13 CFR 140.2 - What is a debt and how can the SBA collect it through offset?

    Science.gov (United States)

    2010-01-01

    ... collect it through offset? 140.2 Section 140.2 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DEBT COLLECTION Offset § 140.2 What is a debt and how can the SBA collect it through offset? (a) A.... (1) Administrative offset. SBA may withhold money it owes to the debtor in order to satisfy the...

  3. 40 CFR 417.140 - Applicability; description of the neutralization of sulfuric acid esters and sulfonic acids...

    Science.gov (United States)

    2010-07-01

    ... neutralization of sulfuric acid esters and sulfonic acids subcategory. 417.140 Section 417.140 Protection of... MANUFACTURING POINT SOURCE CATEGORY Neutralization of Sulfuric Acid Esters and Sulfonic Acids Subcategory § 417.140 Applicability; description of the neutralization of sulfuric acid esters and sulfonic acids...

  4. 17 CFR 140.20 - Designation of senior official to oversee Commission use of national security information.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Designation of senior official to oversee Commission use of national security information. 140.20 Section 140.20 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION ORGANIZATION, FUNCTIONS, AND PROCEDURES OF THE COMMISSION Functions § 140.20 Designation...

  5. 41 CFR 102-73.140 - When may agencies that do not possess independent leasing authority lease space?

    Science.gov (United States)

    2010-07-01

    ... do not possess independent leasing authority lease space? 102-73.140 Section 102-73.140 Public... MANAGEMENT REGULATION REAL PROPERTY 73-REAL ESTATE ACQUISITION Acquisition by Lease Delegations of Leasing Authority § 102-73.140 When may agencies that do not possess independent leasing authority lease...

  6. 10 CFR 140.84 - Criterion I-Substantial discharge of radioactive material or substantial radiation levels offsite.

    Science.gov (United States)

    2010-01-01

    ... or substantial radiation levels offsite. 140.84 Section 140.84 Energy NUCLEAR REGULATORY COMMISSION... § 140.84 Criterion I—Substantial discharge of radioactive material or substantial radiation levels... radioactive material offsite, or that there have been substantial levels of radiation offsite, when, as...

  7. 45 CFR 287.140 - With whom should the Tribe coordinate in the operation of its work activities and services?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false With whom should the Tribe coordinate in the operation of its work activities and services? 287.140 Section 287.140 Public Welfare Regulations Relating... and Operations § 287.140 With whom should the Tribe coordinate in the operation of its work...

  8. 41 CFR 102-38.140 - What must we include in the public notice on sale of personal property?

    Science.gov (United States)

    2010-07-01

    ... REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL PROPERTY Sales Process Advertising § 102-38.140 What must we include in the public notice on sale of personal property? In the public notice, you must provide... the public notice on sale of personal property? 102-38.140 Section 102-38.140 Public Contracts and...

  9. 17 CFR 140.91 - Delegation of authority to the Director of the Division of Trading and Markets.

    Science.gov (United States)

    2010-04-01

    ... Director of the Division of Trading and Markets. 140.91 Section 140.91 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION ORGANIZATION, FUNCTIONS, AND PROCEDURES OF THE COMMISSION Functions § 140.91 Delegation of authority to the Director of the Division of Trading and Markets. (a)...

  10. Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α

    Science.gov (United States)

    Na, Jung-Hyun; Lee, Won-Kyu; Kim, Yuyoung; Jeong, Cherlhyun; Song, Seung Soo; Cha, Sun-Shin; Han, Kyou-Hoon; Shin, Yeon-Kyun; Yu, Yeon Gyu

    2017-01-01

    Nucleolar phosphoprotein 140 (Nopp140) is a nucleolar protein, more than 80% of which is disordered. Previous studies have shown that the C-terminal region of Nopp140 (residues 568–596) interacts with protein kinase CK2α, and inhibits the catalytic activity of CK2. Although the region of Nopp140 responsible for the interaction with CK2α was identified, the structural features and the effect of this interaction on the structure of Nopp140 have not been defined due to the difficulty of structural characterization of disordered protein. In this study, the disordered feature of Nopp140 and the effect of CK2α on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR). The interaction with CK2α was increased conformational rigidity of the CK2α-interacting region of Nopp140 (Nopp140C), suggesting that the disordered and flexible conformation of Nopp140C became more rigid conformation as it binds to CK2α. In addition, site specific spin labeling and EPR analysis confirmed that the residues 574–589 of Nopp140 are critical for binding to CK2α. Similar technical approaches can be applied to analyze the conformational changes in other IDPs during their interactions with binding partners. PMID:27297113

  11. Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40).

    Science.gov (United States)

    Frackowiak, Teresa; Baczek, Tomasz; Roman, Kaliszana; Zbikowska, Beata; Gleńsk, Michał; Fecka, Izabela; Cisowski, Wojciech

    2006-01-01

    The primary aim of this work was to determine the interactions of an oxindole alkaloid (mitraphylline) isolated from Uncaria tomentosa with beta-amyloid 1-40 (Abeta1-40 protein) applying the capillary electrophoresis (CE) method. Specifically the Hummel-Dreyer method and Scatchard analysis were performed to study the binding of oxindole alkaloids with Abeta1-40 protein. Prior to these studies extraction of the alkaloid of interest was carried out. Identification of the isolated alkaloid was performed by the use of thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) combined with electrospray ionization mass spectrometry (ESI-MS). The proposed approach was proved to be an efficient and accurate method for specific compound isolation and identification purposes. Moreover, analytical information from the CE approach can be considered as the valuable tool for binding constant determination. The binding constant of mitraphylline with Abeta1-40 protein determined by the Hummel-Dreyer method and Scatchard analysis equals K = 9.95 x 10(5) M(-1). The results obtained showed the significant binding of the tested compound with Abeta1-40 protein. These results are discussed and interpreted in the view of developing a strategy for identification of novel compounds of great importance in Alzheimer disease therapy.

  12. Surface chemistry of lipid raft and amyloid Aβ (1-40) Langmuir monolayer.

    Science.gov (United States)

    Thakur, Garima; Pao, Christine; Micic, Miodrag; Johnson, Sheba; Leblanc, Roger M

    2011-10-15

    Lipid rafts being rich in cholesterol and sphingolipids are considered to provide ordered lipid environment in the neuronal membranes, where it is hypothesized that the cleavage of amyloid precursor protein (APP) to Aβ (1-40) and Aβ (1-42) takes place. It is highly likely that the interaction of lipid raft components like cholesterol, sphingomylein or GM1 leads to nucleation of Aβ and results in aggregation or accumulation of amyloid plaques. One has investigated surface pressure-area isotherms of the lipid raft and Aβ (1-40) Langmuir monolayer. The compression-decompression cycles and the stability of the lipid raft Langmuir monolayer are crucial parameters for the investigation of interaction of Aβ (1-40) with the lipid raft Langmuir monolayer. It was revealed that GM1 provides instability to the lipid raft Langmuir monolayer. Adsorption of Aβ (1-40) onto the lipid raft Langmuir monolayer containing neutral (POPC) or negatively charged phospholipid (DPPG) was examined. The adsorption isotherms revealed that the concentration of cholesterol was important for adsorption of Aβ (1-40) onto the lipid raft Langmuir monolayer containing POPC whereas for the lipid raft Langmuir monolayer containing DPPG:cholesterol or GM1 did not play any role. In situ UV-vis absorption spectroscopy supported the interpretation of results for the adsorption isotherms.

  13. Absence of R140Q mutation of isocitrate dehydrogenase 2 in gliomas and breast cancers.

    Science.gov (United States)

    Raynaud, Stéphane; Carbuccia, Nadine; Colin, Carole; Adélaïde, José; Mozziconacci, Marie-Joelle; Metellus, Philippe; Chinot, Olivier; Birnbaum, Daniel; Chaffanet, Max; Figarella-Branger, Dominique

    2010-09-01

    Somatic mutations of isocitrate dehydrogenase (IDH)-1 and IDH2 proteins have been described in gliomas. The mutations target the R132 amino acid residue and the R172 residue in IDH1 and IDH2, respectively. The same mutations were observed in acute myeloid leukemias with normal karyotype, but a new mutation in IDH2 (R140Q substitution) was detected in malignant myeloid diseases and appears to be the most frequent IDH mutation in these pathologies. To the best of our knowledge, no study thus far has reported the presence of this R140Q mutation in IDH2 in tumors of the nervous system and breast cancers. We evaluated IDH1 and IDH2 exon 4 in 48 low-grade gliomas, 58 primary glioblastomas and 94 breast cancers to evaluate the frequency of mutation and investigated the R140Q substitution in IDH2. The results were compared to our recently obtained results in hematopoietic diseases. The frequency of IDH1 and IDH2 mutations in our panel of gliomas was similar to previously reported mutations. No IDH2 R140 mutation was observed. Compared to hematopoietic diseases, the IDH2 R172 mutation was also more rare and IDH1 mutations more prominent in tumors of the nervous system. No IDH1 or IDH2 mutation was detected in the 94 breast cancer samples. Thus, the IDH2 R140 mutation appears to be restricted to hematopoietic diseases.

  14. Isolation of Renewable Phenolics by Adsorption on Ultrastable Hydrophobic MIL-140 Metal-Organic Frameworks.

    Science.gov (United States)

    Van de Voorde, Ben; Damasceno Borges, Daiane; Vermoortele, Frederik; Wouters, Robin; Bozbiyik, Belgin; Denayer, Joeri; Taulelle, Francis; Martineau, Charlotte; Serre, Christian; Maurin, Guillaume; De Vos, Dirk

    2015-09-21

    The isolation and separation of phenolic compounds from aqueous backgrounds is challenging and will gain in importance as we become more dependent on phenolics from lignocellulose-derived bio-oil to meet our needs for aromatic compounds. Herein, we show that highly stable and hydrophobic Zr metal-organic frameworks of the MIL-140 type are effective adsorbent materials for the separation of different phenolics and far outperform other classes of porous solids (silica, zeolites, carbons). The mechanism of the hydroquinone-catechol separation on MIL-140C was studied in detail by combining experimental results with computational techniques. Although the differences in adsorption enthalpy between catechol and hydroquinone are negligible, the selective uptake of catechol in MIL-140C is explained by its dense π-π stacking in the pores. The interplay of enthalpic and entropic effects allowed separation of a complex, five-compound phenol mixture through breakthrough over a MIL-140C column. Unlike many other metal-organic frameworks, MIL-140C is remarkably stable and maintained structure, porosity and performance after five adsorption-desorption cycles.

  15. let-7 and miR-140 microRNAs coordinately regulate skeletal development.

    Science.gov (United States)

    Papaioannou, Garyfallia; Inloes, Jennifer B; Nakamura, Yukio; Paltrinieri, Elena; Kobayashi, Tatsuya

    2013-08-27

    MicroRNAs (miRNAs) play critical roles in multiple processes of skeletal development. A global reduction of miRNAs in growth plate chondrocytes results in defects in both proliferation and differentiation; however, specific microRNAs responsible for these defects have not been identified. In this study, we provide evidence that let-7 miRNAs and microRNA-140 (miR-140), among other miRNAs expressed in chondrocytes, play major roles in endochondral bone development. We overexpressed lin-28 homolog A (Lin28a) to inhibit let-7 miRNA biogenesis in growth plate chondrocytes. Lin28a overexpression efficiently and specifically reduced let-7 miRNAs and up-regulated let-7 target genes. However, unlike the previous notion that let-7 miRNAs inhibit proliferation and growth, suppression of let-7 miRNAs via Lin28a overexpression decreased proliferation in growth plate chondrocytes, likely through up-regulation of the let-7 target cell cycle regulators cell division cycle 34 (Cdc34) and E2F transcription factor 5 (E2F5). Deficiency of the chondrocyte-specific miRNA, miR-140, causes a differentiation defect in growth plate chondrocytes. Although either Lin28a overexpression or miR-140 deficiency alone caused only mild growth impairment, mice with both miR-140 deficiency and Lin28a overexpression in chondrocytes showed a dramatic growth defect. Deregulation of distinct processes in the absence of these miRNAs synergistically decreased the proliferating chondrocyte mass; miR-140 deficiency reduced differentiation into proliferating chondrocytes, whereas Lin28a overexpression decreased proliferation per se.

  16. Design and operation of 140 GHz gyrotron oscillators for power levels up to 1 MW CW

    Energy Technology Data Exchange (ETDEWEB)

    Jory, H.; Bier, R.; Craig, L.J.; Felch, K.; Ives, L.; Lopez, N.; Spang, S.

    1986-12-01

    Varian has designed and tested 140 GHz gyrotron oscillators that have generated output powers of 100 kW CW and 200 kW for 1 ms pulses. Upcoming tubes will be designed to operate at power levels of 200 kW CW and ultimately up to 1 MW CW. The important design considerations which are addressed in the higher power tubes include the design of the electron gun, interaction circuit, and output window. These issues will be discussed and the results of the earlier 140 GHz gyrotron work at Varian will be summarized.

  17. Thioflavin T templates amyloid β(1-40) conformation and aggregation pathway

    DEFF Research Database (Denmark)

    Di Carlo, Maria Giovanna; Minicozzi, Velia; Foderà, Vito;

    2015-01-01

    in turn rests on the reliability of the probe/labels involved. Here we present evidences of the effect of Thioflavin T (ThT), a worldwide used fluorescent dye to monitor amyloid growth, on the Aβ(1-40) conformation, stability and aggregation. By combining experimental information and Molecular Dynamics...... simulation results, we show that the presence of ThT in solution affects peptide conformation inducing peculiar supramolecular association. In particular ThT interactions with specific Aβ(1-40) residues promote a rigid partially-folded conformation which shifts the balance between different species...

  18. Twenty Years On!: Updating the IEA BESTEST Building Thermal Fabric Test Cases for ASHRAE Standard 140

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Neymark, J. [J. Neymark & Associates, Golden, CO (United States)

    2013-07-01

    ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs applies the IEA BESTEST building thermal fabric test cases and example simulation results originally published in 1995. These software accuracy test cases and their example simulation results, which comprise the first test suite adapted for the initial 2001 version of Standard 140, are approaching their 20th anniversary. In response to the evolution of the state of the art in building thermal fabric modeling since the test cases and example simulation results were developed, work is commencing to update the normative test specification and the informative example results.

  19. 140 GHz gyrotron development program. Quarterly report No. 4, January-March 1985

    Energy Technology Data Exchange (ETDEWEB)

    Felch, K.L.; Bier, R.E.; Craig, L.J.; Fox, L.J.; Hu, G.; Huey, H.E.; Ives, R.L.; Jory, H.R.; Lopez, N.C.; Reysner, P.I.

    1986-01-01

    The objective of this program is to develop a gyrotron oscillator capable of producing 100 kW CW at 140 GHz. Further analysis of the electron guns, interaction cavity, and beam tunnel designs for the first two experimental tubes, Experimental Tube 1 and preprototype Tube 1, is presented. A window deflection tester has been built and initial deflection test results are given. The first 140 GHz gyrotron magnet has successfully passed the major points in the acceptance test. The detailed results of the magnet acceptance test are discussed. Progress concerning the fabrication of 149 GHz gyrotron components, diagnostics, and protective devices, as well as the status of Experimental Tube 1, are summarized.

  20. 140 miljonit

    Index Scriptorium Estoniae

    2006-01-01

    Sotheby oksjonil müüdi 20. saj. abstraktse kunsti olulisema autori Jackson Pollocki umbes 2,5 x 1,25 meetri suurune teos "No. 5, 1948". Uus omanik Mehhiko ärimees David Martinez, endine omanik Hollywoodi meelelahutusärimees David Geffen

  1. 140 miljonit

    Index Scriptorium Estoniae

    2006-01-01

    Sotheby oksjonil müüdi 20. saj. abstraktse kunsti olulisema autori Jackson Pollocki umbes 2,5 x 1,25 meetri suurune teos "No. 5, 1948". Uus omanik Mehhiko ärimees David Martinez, endine omanik Hollywoodi meelelahutusärimees David Geffen

  2. T140

    Directory of Open Access Journals (Sweden)

    M. Yakubovskaya

    2015-11-01

    Epigenetic studies of xenobiotic-induced mechanisms will reveal valuable information clarifying both mechanisms of desirable therapy and side effects and open potential drug design directions. The major challenge that remains is to determine how epigenetic control is regulated and how it might be possible to intervene in such processes.

  3. Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α

    Energy Technology Data Exchange (ETDEWEB)

    Na, Jung-Hyun [Department of Chemistry, Kookmin University, Jeongneung-dong, Seongbuk-gu, Seoul 02707 (Korea, Republic of); Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792 (Korea, Republic of); Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760 (Korea, Republic of); Lee, Won-Kyu [Department of Chemistry, Kookmin University, Jeongneung-dong, Seongbuk-gu, Seoul 02707 (Korea, Republic of); Kim, Yuyoung; Jeong, Cherlhyun [Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792 (Korea, Republic of); Song, Seung Soo [Department of Chemistry, Kookmin University, Jeongneung-dong, Seongbuk-gu, Seoul 02707 (Korea, Republic of); Cha, Sun-Shin [Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760 (Korea, Republic of); Han, Kyou-Hoon [Division of Biosystems Research, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141 (Korea, Republic of); Shin, Yeon-Kyun [Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792 (Korea, Republic of); Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011 (United States); Yu, Yeon Gyu, E-mail: ygyu@kookmin.ac.kr [Department of Chemistry, Kookmin University, Jeongneung-dong, Seongbuk-gu, Seoul 02707 (Korea, Republic of)

    2016-08-19

    Nucleolar phosphoprotein 140 (Nopp140) is a nucleolar protein, more than 80% of which is disordered. Previous studies have shown that the C-terminal region of Nopp140 (residues 568–596) interacts with protein kinase CK2α, and inhibits the catalytic activity of CK2. Although the region of Nopp140 responsible for the interaction with CK2α was identified, the structural features and the effect of this interaction on the structure of Nopp140 have not been defined due to the difficulty of structural characterization of disordered protein. In this study, the disordered feature of Nopp140 and the effect of CK2α on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR). The interaction with CK2α was increased conformational rigidity of the CK2α-interacting region of Nopp140 (Nopp140C), suggesting that the disordered and flexible conformation of Nopp140C became more rigid conformation as it binds to CK2α. In addition, site specific spin labeling and EPR analysis confirmed that the residues 574–589 of Nopp140 are critical for binding to CK2α. Similar technical approaches can be applied to analyze the conformational changes in other IDPs during their interactions with binding partners. - Highlights: • Nopp140 is intrinsically disordered protein (IDP). • Conformation of Nopp140 became more rigid conformation due to interaction with CK2α. • smFRET and EPR could be applied to analyze the structural changes of IDPs.

  4. miRNA-140在骨性关节炎中的研究进展%Research progress of miRNA-140 in Osteoarthritis(OA)

    Institute of Scientific and Technical Information of China (English)

    赵振国

    2012-01-01

    骨性关节炎(OA)是伴随疼痛和关节运动障碍的一种以关节软骨退变和关节周围形成骨质增生为病理特征的慢性进行性骨关节病.临床治疗往往不能令人满意.在 OA 治疗新进展中基因网络得到广泛研究,尤其是 MicroRNA 在OA的发病机制过程中有所表达并具有调控降解和修复等作用.该文通过 miRNA结构功能;miRNA-140在OA的发病中调控机制、作用靶点以及miRNA-140在骨生长板的作用机制结合近几年的国内外研究做一综述.%Osteoarthritis( OA ) is chronic pathological joints disease accompanied by pain and joint dysfunction, which has pathological features of a change of cartilages and hyperplasia around bones. Its clinical treatment tends to be unsatisfactory. Novel targets in OA include genes that are involved in OA pathophysiology,which have been discovered by using gene network, epigenetic and microRNA( miRNA ) approaches. Further insights into the molecular mechanisms involved in OA initiation and progression may lead to the development of new therapies that can control joint destruction and stimulate repair. The present review summarizes the structure and function of miRNA,regulation mechanism and action targets of miRNA in OA and the mechanism of miRNA-140 in bone growth plate.

  5. Correlation between receptor-interacting protein 140 expression and directed differentiation of human embryonic stem cells into neural stem cells

    Science.gov (United States)

    Zhao, Zhu-ran; Yu, Wei-dong; Shi, Cheng; Liang, Rong; Chen, Xi; Feng, Xiao; Zhang, Xue; Mu, Qing; Shen, Huan; Guo, Jing-zhu

    2017-01-01

    Overexpression of receptor-interacting protein 140 (RIP140) promotes neuronal differentiation of N2a cells via extracellular regulated kinase 1/2 (ERK1/2) signaling. However, involvement of RIP140 in human neural differentiation remains unclear. We found both RIP140 and ERK1/2 expression increased during neural differentiation of H1 human embryonic stem cells. Moreover, RIP140 negatively correlated with stem cell markers Oct4 and Sox2 during early stages of neural differentiation, and positively correlated with the neural stem cell marker Nestin during later stages. Thus, ERK1/2 signaling may provide the molecular mechanism by which RIP140 takes part in neural differentiation to eventually affect the number of neurons produced.

  6. Correlation between receptor-interacting protein 140 expression and directed differentiation of human embryonic stem cells into neural stem cells.

    Science.gov (United States)

    Zhao, Zhu-Ran; Yu, Wei-Dong; Shi, Cheng; Liang, Rong; Chen, Xi; Feng, Xiao; Zhang, Xue; Mu, Qing; Shen, Huan; Guo, Jing-Zhu

    2017-01-01

    Overexpression of receptor-interacting protein 140 (RIP140) promotes neuronal differentiation of N2a cells via extracellular regulated kinase 1/2 (ERK1/2) signaling. However, involvement of RIP140 in human neural differentiation remains unclear. We found both RIP140 and ERK1/2 expression increased during neural differentiation of H1 human embryonic stem cells. Moreover, RIP140 negatively correlated with stem cell markers Oct4 and Sox2 during early stages of neural differentiation, and positively correlated with the neural stem cell marker Nestin during later stages. Thus, ERK1/2 signaling may provide the molecular mechanism by which RIP140 takes part in neural differentiation to eventually affect the number of neurons produced.

  7. 47 CFR 25.140 - Qualifications of fixed-satellite space station licensees.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Qualifications of fixed-satellite space station... CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space Stations § 25.140 Qualifications of fixed-satellite space station licensees. (a) New fixed-satellites shall comply with...

  8. Potential Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Inhibitor from Traditional Chinese Medicine against Cancers

    Directory of Open Access Journals (Sweden)

    Wen-Yuan Lee

    2014-01-01

    Full Text Available A recent research of cancer has indicated that the mutant of isocitrate dehydrogenase 1 and 2 (IDH1 and 2 genes will induce various cancers, including chondrosarcoma, cholangiocarcinomas, and acute myelogenous leukemia due to the effect of point mutations in the active-site arginine residues of isocitrate dehydrogenase (IDH, such as IDH1/R132, IDH2/R140, and IDH2/R172. As the inhibition for those tumor-associated mutant IDH proteins may induce differentiation of those cancer cells, these tumor-associated mutant IDH proteins can be treated as a drug target proteins for a differentiation therapy against cancers. In this study, we aim to identify the potent TCM compounds from the TCM Database@Taiwan as lead compounds of IDH2 R140Q mutant inhibitor. Comparing to the IDH2 R140Q mutant protein inhibitor, AGI-6780, the top two TCM compounds, precatorine and abrine, have higher binding affinities with target protein in docking simulation. After MD simulation, the top two TCM compounds remain as the same docking poses under dynamic conditions. In addition, precatorine is extracted from Abrus precatorius L., which represents the cytotoxic and proapoptotic effects for breast cancer and several tumor lines. Hence, we propose the TCM compounds, precatorine and abrine, as potential candidates as lead compounds for further study in drug development process with the IDH2 R140Q mutant protein against cancer.

  9. Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers.

    Science.gov (United States)

    Lee, Wen-Yuan; Chen, Kuan-Chung; Chen, Hsin-Yi; Chen, Calvin Yu-Chian

    2014-01-01

    A recent research of cancer has indicated that the mutant of isocitrate dehydrogenase 1 and 2 (IDH1 and 2) genes will induce various cancers, including chondrosarcoma, cholangiocarcinomas, and acute myelogenous leukemia due to the effect of point mutations in the active-site arginine residues of isocitrate dehydrogenase (IDH), such as IDH1/R132, IDH2/R140, and IDH2/R172. As the inhibition for those tumor-associated mutant IDH proteins may induce differentiation of those cancer cells, these tumor-associated mutant IDH proteins can be treated as a drug target proteins for a differentiation therapy against cancers. In this study, we aim to identify the potent TCM compounds from the TCM Database@Taiwan as lead compounds of IDH2 R140Q mutant inhibitor. Comparing to the IDH2 R140Q mutant protein inhibitor, AGI-6780, the top two TCM compounds, precatorine and abrine, have higher binding affinities with target protein in docking simulation. After MD simulation, the top two TCM compounds remain as the same docking poses under dynamic conditions. In addition, precatorine is extracted from Abrus precatorius L., which represents the cytotoxic and proapoptotic effects for breast cancer and several tumor lines. Hence, we propose the TCM compounds, precatorine and abrine, as potential candidates as lead compounds for further study in drug development process with the IDH2 R140Q mutant protein against cancer.

  10. 42 CFR 440.140 - Inpatient hospital services, nursing facility services, and intermediate care facility services...

    Science.gov (United States)

    2010-10-01

    ... Definitions § 440.140 Inpatient hospital services, nursing facility services, and intermediate care facility... 42 Public Health 4 2010-10-01 2010-10-01 false Inpatient hospital services, nursing facility services, and intermediate care facility services for individuals age 65 or older in institutions...

  11. 33 CFR 334.140 - Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md.

    Science.gov (United States)

    2010-07-01

    ....140 Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md. (a) Restricted area defined. The following indicates the limits of the waters of or adjacent to the Aberdeen Proving Ground, Maryland, and inside of which boundaries will lie the restricted area known as the Aberdeen Proving...

  12. Nature of the pygmy dipole resonance in Ce-140 studied in (alpha, alpha 'gamma) experiments

    NARCIS (Netherlands)

    Savran, D.; Babilon, M.; van den Berg, A. M.; Harakeh, M. N.; Hasper, J.; Matic, A.; Wortche, H. J.; Zilges, A.

    2006-01-01

    A concentration of electric-dipole excitations below the particle threshold, which is frequently denoted as the pygmy dipole resonance, has been studied in the semimagic nucleus Ce-140 in (alpha, alpha(')gamma) experiments at E-alpha=136 MeV. The technique of alpha-gamma coincidence experiments allo

  13. Gamma-ray scintillation counter hodoscope for the experiment S140

    CERN Multimedia

    1975-01-01

    The experiment S140 was set-up in the East Hall (beam p14) by the CERN-Munich-Cracow Collaboration to study the production by negative kaons of a neutral meson associated to a Lambda. Here, the liquid hydrogen target (inside the horizontal black tube) is withdrawn from the surrounding cylindrical gamma-ray-measuring scintillation counter hodoscope.

  14. Productivity fluctuations in the southeastern Arabian Sea during the last 140 ka

    Digital Repository Service at National Institute of Oceanography (India)

    Pattan, J.N.; Toshiyuki Masuzawab; Naidu, P.D.; Parthiban, G.; Mineko Yamamoto

    the palaeoproductivity fluctuations over the last 140 ka. High calcium carbonate, biogenic opal, biogenic Ba contents (wt%) and their mass accumulation rates (g/cm u2/ka) suggest higher productivity during major interglacials than in the glacials. Organic carbon content...

  15. 13 CFR 108.140 - SBA approval of initial Management Expenses.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBA approval of initial Management... VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.140 SBA approval of initial Management Expenses. A NMVC Company must have its Management Expenses...

  16. 13 CFR 107.140 - SBA approval of initial Management Expenses.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBA approval of initial Management... BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Organizing An Sbic § 107.140 SBA approval of initial Management Expenses. If you plan to obtain Leverage, you must have your Management...

  17. 40 CFR 81.140 - Northwest Arkansas Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Air Quality Control Regions § 81.140 Northwest Arkansas Intrastate Air Quality Control Region. The Northwest Arkansas Intrastate Air Quality Control Region consists of the territorial area encompassed by the... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Northwest Arkansas Intrastate...

  18. 46 CFR 28.140 - Operational readiness, maintenance, and inspection of lifesaving equipment.

    Science.gov (United States)

    2010-10-01

    ... month and year on its servicing sticker affixed under 46 CFR 160.151-57(n), and whenever the container... specifically approved by the Commandant for the particular brand. (d) An escape route from a space where an... wearable personal flotation device (Type V commercial hybrid) Servicing 28.140 (2) Personal...

  19. Restructuring the ISO 140 series for the future: background and approach

    NARCIS (Netherlands)

    Rasmussen, B.; Gerretsen, E.

    2005-01-01

    ISO 140 is the basic series of standards in Building Acoustics and consists of several parts relating to laboratory and field measurements. The standards were originally prepared by ISO/TC43/SC2 WGs in the early sixties and since then updated and implemented as European standards through CEN/TC126.

  20. 40 CFR 40.140-3 - Federal Water Pollution Control Act.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Federal Water Pollution Control Act. 40... FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.140-3 Federal Water Pollution Control Act. (a... such safe water and such elimination or control of water pollution for all native villages in the...

  1. 28 CFR 0.140 - Authority relating to advertisements, and purchase of certain supplies and services.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Authority relating to advertisements, and... Administrative Matters § 0.140 Authority relating to advertisements, and purchase of certain supplies and... action in the following-described matters: (a) Authorizing the publication of advertisements, notices,...

  2. 13 CFR 120.140 - What ethical requirements apply to participants?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What ethical requirements apply to... LOANS Policies Applying to All Business Loans Ethical Requirements § 120.140 What ethical requirements... “Participants”), must act ethically and exhibit good character. Ethical indiscretion of an Associate of...

  3. Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

    Directory of Open Access Journals (Sweden)

    Daniela Meleleo

    2010-01-01

    Full Text Available Nicotinic acetylcholine receptors (AChRs, implicated in memory and learning, in subjects affected by Alzheimer's disease result altered. Stimulation of α7-nAChRs inhibits amyloid plaques and increases ACh release. β-amyloid peptide (AβP forms ion channels in the cell and model phospholipid membranes that are retained responsible in Alzheimer disease. We tested if choline, precursor of ACh, could affect the AβP1-40 channels in oxidized cholesterol (OxCh and in palmitoyl-oleoyl-phosphatidylcholine (POPC:Ch lipid bilayers. Choline concentrations of 5 × 10−11 M–1.5 × 10−8 M added to the cis- or trans-side of membrane quickly increased AβP1-40 ion channel frequency (events/min and ion conductance in OxCh membranes, but not in POPC:Ch membranes. Circular Dichroism (CD spectroscopy shows that after 24 and 48 hours of incubation with AβP1-40, choline stabilizes the random coil conformation of the peptide, making it less prone to fibrillate. These actions seem to be specific in that ACh is ineffective either in solution or on AβP1-40 channel incorporated into PLMs.

  4. Overlapping transcription structure of human cytomegalovirus UL140 and UL141 genes

    Indian Academy of Sciences (India)

    Yanping Ma; Mali Li; Bo Zheng; Ning Wang; Shuang Gao; Lin Wang; Qi Ying; Zhengrong Sun; Qiang Ruan

    2013-03-01

    Transcription of human cytomegalovirus UL/b′ region has been studied extensively for some genes. In this study, transcripts of the UL140 and UL141, two of the UL/b′ genes, were identified in late RNAs of three HCMV isolates using Northern blot hybridization, cDNA library screening and RACE-PCR. At least three transcripts with length of 2800, 2400 and 1700 nt, as well as a group of transcripts of about 1000–1300 nt, were found in this gene region with an accordant 3′ ends. Among the transcripts, two initiated upstream of the start code of the UL140 gene and contained the UL140 and UL141 open reading frame (ORF), one initiated in the middle of the UL140 gene, and could encode short ORFs upstream of the UL141 ORF. A group of transcripts initiated upstream or downstream of the start code of the UL141 gene, and could encode `nested’ ORFs, including the UL141 ORF. These `nested’ ORFs possess different initiation sites but the same termination site as that of the UL141 ORF.

  5. 22 CFR 140.8 - Recipients of scholarships, fellowships, and participant training.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recipients of scholarships, fellowships, and... ASSISTANCE TO DRUG TRAFFICKERS Enforcement § 140.8 Recipients of scholarships, fellowships, and participant... of scholarships, fellowships, or participant training, except those falling under the...

  6. 24 CFR 943.140 - What programs and activities are covered by this subpart?

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT PUBLIC HOUSING AGENCY CONSORTIA AND JOINT VENTURES Subsidiaries, Affiliates, Joint Ventures in Public Housing § 943.140 What programs and activities are covered by this... requirements of part 941, subpart F, of this title. (b) For purposes of this subpart, the term “joint...

  7. 78 FR 4858 - Agency Information Collection Activities: Immigrant Petition for Alien Workers, Form I-140...

    Science.gov (United States)

    2013-01-23

    ... Petition for Alien Workers, Form I-140; Revision of a Currently Approved Collection ACTION: 30-Day notice...: Revision of a Currently Approved Collection. (2) Title of the Form/Collection: Immigrant Petition for Alien... USCIS to classify aliens under sections 203(b)(1), 203(b)(2) or 203(b)(3) of the Immigration...

  8. Water and ammonia abundances in S140 with the Odin satellite

    NARCIS (Netherlands)

    Persson, C. M.; Olberg, M.; Hjalmarson, A.; Spaans, M.; Black, J. H.; Frisk, U.; Liljestrom, T.; Olofsson, A. O. H.; Poelman, D. R.; Sandqvist, Aa.

    Aims. We investigate the effect of the physical environment on water and ammonia abundances across the S140 photodissociation region (PDR) with an embedded outflow. Methods. We used the Odin satellite to obtain strip maps of the ground-state rotational transitions of ortho-water and ortho-ammonia,

  9. The excitation of water in the S140 photon dominated region

    NARCIS (Netherlands)

    Poelman, DR; Spaans, M

    We consider the excitation of water in the Photon Dominated Region (PDR) S140. With the use of a three-dimensional escape probability method we compute the level populations of ortho- and para-H(2)O up to similar to 350 K ( i. e., 8 levels), as well as line intensities for various transitions.

  10. Characterization of Single-Photon Avalanche Diodes in Standard 140-nm SOI CMOS Technology

    NARCIS (Netherlands)

    Lee, M.J.; Sun, P.; Charbon, E.

    2015-01-01

    We report on the characterization of single-photon avalanche diodes (SPADs) fabricated in standard 140-nm silicon on insulator (SOI) complementary metal-oxide-semiconductor (CMOS) technology. As a methodology for SPAD optimization, a test structure array, called SPAD farm, was realized with several

  11. 7 CFR 946.140 - Handling potatoes for commercial processing into products.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Handling potatoes for commercial processing into... AGRICULTURE IRISH POTATOES GROWN IN WASHINGTON Rules and Regulations Modification of Inspection Requirements § 946.140 Handling potatoes for commercial processing into products. Pursuant to § 946.54(a)(6...

  12. 40 CFR 63.140 - Process wastewater provisions-delay of repair.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Process wastewater provisions-delay of... Manufacturing Industry for Process Vents, Storage Vessels, Transfer Operations, and Wastewater § 63.140 Process wastewater provisions—delay of repair. (a) Delay of repair of equipment for which a control equipment...

  13. NCAM-140 Translocation into Lipid Rafts Mediates the Neuroprotective Effects of GDNF.

    Science.gov (United States)

    Li, Li; Chen, Huizhen; Wang, Meng; Chen, Fangfang; Gao, Jin; Sun, Shen; Li, Yunqing; Gao, Dianshuai

    2017-05-01

    Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for substantia nigra dopaminergic (DA) neuronal cells. Recent studies have demonstrated that neural cell adhesion molecule functions as a signal transduction receptor for GDNF. The purpose of this study is to reveal whether neural cell adhesion molecule (NCAM) mediates the protective effects of GDNF on DA neuronal cells and further explore the mechanisms involved. We utilized SH-SY5Y cell line to establish a model of 6-hydroxydopamine (6-OHDA)-injured DA neuronal cells. Lentiviral vectors were constructed to knockdown or overexpress NCAM-140, and a density gradient centrifugation method was employed to separate membrane lipid rafts. 3-(4,5-Dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), flow cytometric analysis, and western blotting were used to evaluate the protective effects of GDNF. The results showed that GDNF could protect 6-OHDA-injured SH-SY5Y cells via improving cell viability and decreasing the cell death rate and cleaved caspase-3 expression. NCAM-140 knockdown decreased cell viability and increased the cell death rate and cleaved caspase-3 expression, while its overexpression had the opposite effects. Notably, the amount of NCAM-140 located in lipid rafts increased after GDNF treatment. Pretreatment with 2-bromopalmitate, a specific inhibitor of protein palmitoylation, suppressed NCAM-140 translocation to lipid rafts and reduced the NCAM-mediated protective effects of GDNF on injured DA neuronal cells. Our results suggest that GDNF have the protective effects on injured DA cells by influencing NCAM-140 translocation into lipid rafts.

  14. MDCT findings after elbow dislocation: a retrospective study of 140 patients

    Energy Technology Data Exchange (ETDEWEB)

    Sormaala, Markus J. [Helsinki University Central Hospital, Medical Imaging Center, Helsinki (Finland); Turku University Hospital, Medical Imaging Center, Turku (Finland); Helsinki University Central Hospital, Toeoeloe Trauma Center, Helsinki (Finland); Sormaala, Annastiina; Koskinen, Seppo K. [Helsinki University Central Hospital, Medical Imaging Center, Helsinki (Finland); Helsinki University Central Hospital, Toeoeloe Trauma Center, Helsinki (Finland); Mattila, Ville M. [Tampere University Hospital, Department of Orthopedic Surgery and Trauma, Tampere (Finland); Karolinska Hospital, Department of Orthopedic Surgery, Stockholm (Sweden)

    2014-04-15

    To assess the number and anatomical location of fractures associated with elbow dislocation, to study the correlation between the direction of dislocation and the trauma energy, and to assess radiographs' diagnostic performance characteristics for fractures using MDCT as a reference standard. A retrospective study was performed at a level 1 trauma center, finding a total of 140 patients who had sustained an elbow dislocation and who had undergone a subsequent MDCT examination. The CT and radiographs of the patient were reviewed by two musculoskeletal radiologists. CT images were analyzed for the site and size of the fracture fragments. In addition, the primary direction of the dislocation, patients' age, and gender were recorded. Trauma energy was also assessed. One hundred and thirty-four out of 140 patients (96 %) had a fracture that was seen on the correlative CT examination. The most common anatomical fracture locations were the coronoid process of the ulna 84 out of 140 (60 %), the radial head 75 out of 140 (54 %), and the humeral capitellum 57 out of 140 (41 %). Multiple fractures were seen in 71 out of 134 (53 %) patients with fractures. The left elbow was more commonly dislocated than the right one. The overall sensitivity of the radiographs was 62 % and the specificity 96 %. Small fractures and impaction fractures are almost invariably present in elbow dislocations, and half of the patients have more than one fracture. Radiographs have a sensitivity of only 62 %. MDCT is an invaluable method for determining the extent of bony injury and revealing occult fractures. (orig.)

  15. Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders

    Science.gov (United States)

    Alfieri, Annalisa; Sorokina, Oksana; Adrait, Annie; Angelini, Costanza; Russo, Isabella; Morellato, Alessandro; Matteoli, Michela; Menna, Elisabetta; Boeri Erba, Elisabetta; McLean, Colin; Armstrong, J. Douglas; Ala, Ugo; Buxbaum, Joseph D.; Brusco, Alfredo; Couté, Yohann; De Rubeis, Silvia; Turco, Emilia; Defilippi, Paola

    2017-01-01

    Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD). Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates their maturation and physiology. We recently showed that p140Cap knockout mice have cognitive deficits, impaired long-term potentiation (LTP) and long-term depression (LTD), and immature, filopodia-like dendritic spines. Only a few p140Cap interacting proteins have been identified in the brain and the molecular complexes and pathways underlying p140Cap synaptic function are largely unknown. Here, we isolated and characterized the p140Cap synaptic interactome by co-immunoprecipitation from crude mouse synaptosomes, followed by mass spectrometry-based proteomics. We identified 351 p140Cap interactors and found that they cluster to sub complexes mostly located in the postsynaptic density (PSD). p140Cap interactors converge on key synaptic processes, including transmission across chemical synapses, actin cytoskeleton remodeling and cell-cell junction organization. Gene co-expression data further support convergent functions: the p140Cap interactors are tightly co-expressed with each other and with p140Cap. Importantly, the p140Cap interactome and its co-expression network show strong enrichment in genes associated with schizophrenia, autism, bipolar disorder, intellectual disability and epilepsy, supporting synaptic dysfunction as a shared biological feature in brain diseases. Overall, our data provide novel insights into the molecular organization of the synapse and indicate that p140Cap acts as a hub for postsynaptic complexes relevant to psychiatric and neurological disorders. PMID:28713243

  16. Retrospective analysis of 140 triple-negative breast cancers%140例三阴乳腺癌病例分析

    Institute of Scientific and Technical Information of China (English)

    罗忠兵; 龙浩; 马国伟; 林志潮; 司徒冬荣; 杨名添; 戎铁华

    2009-01-01

    目的:回顾性分析140例三阴乳腺癌病例,旨在了解该院三阴乳腺癌生存及复发情况.方法:收集中山大学肿瘤防治中心2000~2002年间收治的1 125例乳腺癌手术病例,其中140例三阴乳腺癌(其诊断主要基于免疫组化)的病例资料,回顾性分析患者生存情况以及肿瘤复发转移方式.结果:140例三阴乳腺癌患者中位随访时间58个月,5年无病生存率为65.7%,5年总生存率为73.4%.同时期(2000~2002年)该院手术后总的乳腺癌共1 125例,5年生存率为86.7%.二者生存率比较(73.4%VS 86.7%)有统计学意义.78例绝经前三阴乳腺癌患者5年生存率为75.0%,62例绝经后患者5年生存率为71.3%.有45例三阴乳腺癌发生复发转移,其中17例(37.8%)肝转移,23例(51.1%)肺转移,7例(15.6%)脑转移.结论:与总的乳腺癌比较,三阴乳腺癌的预后更差;绝经前后三阴乳腺癌生存率比较无统计学意义;淋巴结阳性三阴乳腺癌生存差于淋巴结阴性的三阴乳腺癌;与总的乳腺癌比较,三阴乳腺癌复发转移以内脏(肺,肝)转移和脑转移多见.%Objective:Retrospectively analyzed 140 triple-negative cases from Cancer Center of Sun Yat-sen University between 2000 and 2002 years to get the message about survival and recurrence of triple negative hreast cancers.Methods:Collected 1 125 postoperative breast cancers from Cancer Center of Sun Yat-sen University between 2000 and 2002 years (including 140 triple-negative patients,diagnosis mainly based on immunohistochemistry) and analyzed recurrence,metastases and survival of them.Results:As of November 2007,with a median follow-up time of 56.4±22.8 months,78 patients are premenopausal.At 5 years,the triple negative had a disease-free survival rate 65.7% and had a survival rate 73.4%.There were 1 125 postoperative breast cancers which had survival rate 86.7% at 5 years in Cancer Center of Sun Yat-sen University between 2000 and 2002 years.Of 140 triple negative breast

  17. 10 CFR 140.93 - Appendix C-Form of indemnity agreement with licensees furnishing proof of financial protection in...

    Science.gov (United States)

    2010-01-01

    ... furnishing proof of financial protection in the form of licensee's resources. 140.93 Section 140.93 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS... proof of financial protection in the form of licensee's resources. This indemnity agreement No. _____...

  18. 40 CFR 1042.140 - Maximum engine power, displacement, power density, and maximum in-use engine speed.

    Science.gov (United States)

    2010-07-01

    ... as specified in 40 CFR 1065.610. This is the maximum in-use engine speed used for calculating the NOX... procedures of 40 CFR part 1065, based on the manufacturer's design and production specifications for the..., power density, and maximum in-use engine speed. 1042.140 Section 1042.140 Protection of...

  19. 20 CFR 666.140 - Which individuals receiving services are included in the core indicators of performance?

    Science.gov (United States)

    2010-04-01

    ... included in the core indicators of performance? 666.140 Section 666.140 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PERFORMANCE ACCOUNTABILITY UNDER TITLE I OF THE WORKFORCE... the core indicators of performance? (a)(1) The core indicators of performance apply to all...

  20. 10 CFR 140.108 - Appendix H-Form of indemnity agreement with licensees possessing plutonium for use in plutonium...

    Science.gov (United States)

    2010-01-01

    ... possessing plutonium for use in plutonium processing and fuel fabrication plants and furnishing proof of... Appendixes to Part 140 § 140.108 Appendix H—Form of indemnity agreement with licensees possessing plutonium for use in plutonium processing and fuel fabrication plants and furnishing proof of...

  1. HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane protein 140

    Energy Technology Data Exchange (ETDEWEB)

    Guan, Ying [Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118 (China); Yunnan Academy of Tobacco Science, Kunming, Yunnan 650106 (China); Guo, Lei; Yang, Erxia; Liao, Yun; Liu, Longding; Che, Yanchun; Zhang, Ying; Wang, Lichun; Wang, Jingjing [Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118 (China); Li, Qihan, E-mail: imbcams.lq@gmail.com [Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118 (China)

    2014-09-15

    During HSV-1 infection, the viral UL31 protein forms a complex with the UL34 protein at the cellular nuclear membrane, where both proteins play important roles in the envelopment of viral nucleocapsids and their egress into the cytoplasm. To characterize the mechanism of HSV-1 nucleocapsid egress, we screened host proteins to identify proteins that interacted with UL31 via yeast two-hybrid analysis. Transmembrane protein 140 (TMEM140), was identified and confirmed to bind to and co-localize with UL31 during viral infection. Further studies indicated that TMEM140 inhibits HSV-1 proliferation through selectively blocking viral nucleocapsid egress during the viral assembly process. The blockage function of TMEM140 is mediated by impeding the formation of the UL31–UL34 complex due to competitive binding to UL31. Collectively, these data suggest the essentiality of the UL31–UL34 interaction in the viral nucleocapsid egress process and provide a new anti-HSV-1 strategy in viral assembly process of nucleocapsid egress. - Highlights: • Cellular TMEM140 protein interacts with HSV-1 UL31 protein during viral infection. • Increasing expression of TMEM140 leads to inhibition of HSV-1 proliferation. • Increasing expression of TMEM140 blocks HSV-1 nucleocapsid egress process. • Binding to UL31 of TMEM140 impedes formation of HSV-1 UL31–UL34 complex.

  2. On the origin of 140 GHz emission from the 4 July 2012 solar flare

    CERN Document Server

    Tsap, Yuriy T; Morgachev, Alexander S; Motorina, Galina G; Kontar, Eduard P; Nagnibeda, Valery G; Strekalova, Polina V

    2016-01-01

    The sub-THz event observed on the 4 July 2012 with the Bauman Moscow State Technical University Radio Telescope RT-7.5 at 93 and 140~GHz as well as Kislovodsk and Mets\\"ahovi radio telescopes, Radio Solar Telescope Network (RSTN), GOES, RHESSI, and SDO orbital stations is analyzed. The spectral flux between 93 and 140 GHz has been observed increasing with frequency. On the basis of the SDO/AIA data the differential emission measure has been calculated. It is shown that the thermal coronal plasma with the temperature above 0.5~MK cannot be responsible for the observed sub-THz flare emission. The non-thermal gyrosynchrotron mechanism can be responsible for the microwave emission near $10$~GHz but the observed millimeter spectral characteristics are likely to be produced by the thermal bremsstrahlung emission from plasma with a temperature of about 0.1~MK.

  3. On the origin of 140 GHz emission from the 4 July 2012 solar flare

    Science.gov (United States)

    Tsap, Yuriy T.; Smirnova, Victoria V.; Morgachev, Alexander S.; Motorina, Galina G.; Kontar, Eduard P.; Nagnibeda, Valery G.; Strekalova, Polina V.

    2016-04-01

    The sub-THz event observed on the 4 July 2012 with the Bauman Moscow State Technical University Radio Telescope RT-7.5 at 93 and 140 GHz as well as Kislovodsk and Metsähovi radio telescopes, Radio Solar Telescope Network (RSTN), GOES, RHESSI, and SDO orbital stations is analyzed. The spectral flux between 93 and 140 GHz has been observed increasing with frequency. On the basis of the SDO/AIA data the differential emission measure has been calculated. It is shown that the thermal coronal plasma with the temperature above 0.5 MK cannot be responsible for the observed sub-THz flare emission. The non-thermal gyrosynchrotron mechanism can be responsible for the microwave emission near 10 GHz but the observed millimeter spectral characteristics are likely to be produced by the thermal bremsstrahlung emission from plasma with a temperature of about 0.1 MK.

  4. High-spin States in Odd-odd 140Pr Nucleus

    Institute of Scientific and Technical Information of China (English)

    YuHaiping; GuoYingxiang; ZhouXiaohong; ZhangYuhu; LeiXiangguo; LiuMinliang; LuoPeng; SongLitao; WangHualei; XieChengying; ZhengYong; GuoWentao; ZhuLihua; WuXiaoguang

    2003-01-01

    The high-spin level structures of doubly odd nucleus 140Pr have been investigated by means of the 130Te(14N,4n)140Pr reaction. The 14N beam was obtained from the HI-13 tandem accelerator of China Institute of Atomic Energy, Beijing. The target is an enriched 130Te metallic foil of 1.67mg/cm2 thickness with a 10.37mg/cm2 Pb backing. Measurements of γ-ray singles, γ-γ-t coincidences and γ-ray excitation function were performed with twelve BGO(AC)HPGe detectors. Based on detailed analysis of γ-γ coincidence relationships, γ-ray

  5. In-Situ Measurements of the Radiation Stability of Amino Acids at 15-140 K

    Science.gov (United States)

    Gerakines, Perry A.; Hudson, Reggie L.; Moore, Marla H.; Bell, Jan-Luca

    2012-01-01

    We present new kinetics data on the radiolytic destruction of amino acids measured in situ with infrared spectroscopy. Samples were irradiated at 15, 100, and 140 K with D.8-MeV protons, and amino-acid decay was followed at each temperature with and without H2O present. Observed radiation products included CO2 and amines, consistent with amino-acid decarboxylation. The half-lives of glycine, alanine, and phenylalanine were estimated for various extraterrestrial environments. Infrared spectral changes demonstrated the conversion from the non-zwitterion structure NH2-CH2(R)-COOH at 15 K to the zwitterion structure +NH3-CH2(R)-COO- at 140 K for each amino acid studied.

  6. 针刺放血疗法治疗疟疾140

    Institute of Scientific and Technical Information of China (English)

    张弘; 任琳

    2003-01-01

    Objective: In Zambia, malaria is very common and the symptoms are very different. The treatment of malaria is very difficult because of the drug resistance to one drug after another. Many patients could not be cured by drug. The author treated malaria 140 cases by bloodletting therapy and obtained successful effect. Methods: The disposable needles were used to prick Erjian point and 8 to 10 drops blood were squeezed out. Then Dazhui point was pricked twice or three times, cupping on the point about 10 minutes and 10 to 20 drops blood were drown out. After that, according to different symptoms of malaria, different points were elected and different therapy was applied in addition. Results: Of the 140 cases, 77 were recovery (55.00%), 51 improved (36.43%), and 12 ineffective (8.57%). The total effective rate was 91.43%. Conclusion: Results show acupuncture is an effective method for treatment of malaria in Zambia.

  7. In situ measurements of the radiation stability of amino acids at 15-140 K

    Science.gov (United States)

    Gerakines, Perry A.; Hudson, Reggie L.; Moore, Marla H.; Bell, Jan-Luca

    2012-08-01

    We present new kinetics data on the radiolytic destruction of amino acids measured in situ with infrared spectroscopy. Samples were irradiated at 15, 100, and 140 K with 0.8-MeV protons, and amino-acid decay was followed at each temperature with and without H2O present. Observed radiation products included CO2 and amines, consistent with amino-acid decarboxylation. The half-lives of glycine, alanine, and phenylalanine were estimated for various extraterrestrial environments. Infrared spectral changes demonstrated the conversion from the non-zwitterion structure NH2sbnd CH2(R)sbnd COOH at 15 K to the zwitterion structure +NH3sbnd CH2(R)sbnd COO- at 140 K for each amino acid studied.

  8. In-situ measurements of the radiation stability of amino acids at 15-140 K

    CERN Document Server

    Gerakines, P A; Moore, M H; Bell, J -L

    2015-01-01

    We present new kinetics data on the radiolytic destruction of amino acids measured in situ with infrared spectroscopy. Samples were irradiated at 15, 100, and 140 K with 0.8-MeV protons, and amino-acid decay was followed at each temperature with and without H$_2$O present. Observed radiation products included CO$_2$ and amines, consistent with amino-acid decarboxylation. The half-lives of glycine, alanine, and phenylalanine were estimated for various extraterrestrial environments. Infrared spectral changes demonstrated the conversion from the non-zwitterion structure NH$_2$-CH$_2$(R)-COOH at 15 K to the zwitterion structure $^+$NH$_3$-CH$_2$(R)-COO$^-$ at 140 K for each amino acid studied.

  9. Burning mouth syndrome: a retrospective study of 140 cases in a sample of Catalan population.

    Science.gov (United States)

    Palacios-Sánchez, Maria F; Jordana-Comín, Xavier; García-Sívoli, Carlos E

    2005-01-01

    The results of analyzing etiologic and clinical factors, and their connection with the burning mouth syndrome (BMS) in a sample of Catalan (Barcelona, Spain) population are presented in this work. The purpose of this study is to establish connections between BMS and the following variables: age, sex, overt depression, masked depression, cancerophobia, dry mouth, foreign body sensation in the mouth, and burning. 140 clinical cases of patients diagnosed with the disease and 140 cases of control patients are studied here. The data were statistically analyzed to study connections as well as the disease and variables frequency. The obtained results will help understanding possible connections of the studied etiologic and clinical factors with the disease, as well as the course of BMS, and its consequences in the Catalan population.

  10. Mod 1 ICS TI Report: ICS Conversion of a 140% HPGe Detector

    Energy Technology Data Exchange (ETDEWEB)

    Bounds, John Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-05

    This report evaluates the Mod 1 ICS, an electrically cooled 140% HPGe detector. It is a custom version of the ORTEC Integrated Cooling System (ICS) modified to make it more practical for us to use in the field. Performance and operating characteristics of the Mod 1 ICS are documented, noting both pros and cons. The Mod 1 ICS is deemed a success. Recommendations for a Mod 2 ICS, a true field prototype, are provided.

  11. The WR 140 periastron passage 2009: first results from MONS and other optical sources

    CERN Document Server

    Fahed, R; Zorec, J; Eversberg, T; Chené, A N; Alves, F; Arnold, W; Bergmann, T; Carreira, L F Gouveia; Dias, F Marques; Fernando, A; Gallego, J Sanchez; Hunger, T; Knapen, J H; Leadbeater, R; Morel, T; Rauw, G; Reinecke, N; Ribeiro, J; Romeo, N; Santos, E M dos; Schanne, L; Stahl, O; Stober, Ba; Stober, Be; Viegas, N G Correia; Vollmann, K; Corcoran, M F; Dougherty, S M; Pittard, J M; Pollock, A M T; Williams, P M

    2011-01-01

    We present the results from the spectroscopic follow-up of WR140 (WC7 + O4-5) during its last periastron passage in January 2009. This object is known as the archetype of colliding wind binaries and has a relatively large period (~ 8 years) and eccentricity (~ 0.89). We provide updated values for the orbital parameters, new estimates for the WR and O star masses and new constraints on the mass-loss rates.

  12. Receptor-interacting Protein 140 Overexpression Promotes Neuro-2a Neuronal Differentiation by ERK1/2 Signaling

    Institute of Scientific and Technical Information of China (English)

    Xiao Feng; Weidong Yu; Rong Liang; Cheng Shi; Zhuran Zhao; Jingzhu Guo

    2015-01-01

    Background:Abnormal neuronal differentiation plays an important role in central nervous system (CNS) development abnormalities such as Down syndrome (DS),a disorder that results directly from overexpression of genes in trisomic cells.Receptor-interacting protein 140 (RIP 140) is significantly upregulated in DS brains,suggesting its involvement in DS CNS development abnormalities.However,the role of RIP140 in neuronal differentiation is still not clear.The current study aimed to investigate the effect of RIP 140 overexpression on the differentiation of neuro-2a (N2a) neuroblastoma cells,in vitro.Methods:Stably RIP 140-overexpressing N2a (N2a-RIP140) cells were used as a neurodevelopmental model,and were constructed by lipofection and overexpression validated by real-time polymerase chain reaction and Western blot.Retinoic acid (RA) was used to stimulate N2a differentiation.Combining the expression of Tuj 1 at the mRNA and protein levels,the percentage of cells baring neurites,and the number of neurites per cell body was semi-quantified to determine the effect of RIP 140 on differentiation of N2a cells.Furthermore,western blot and the ERK1/2 inhibitor U0126 were used to identify the specific signaling pathway by which RIP 140 induces differentiation of N2a cells.Statistical significance of the differences between groups was determined by one-way analysis of variance followed by the Dunnett test.Results:Compared to untransfected N2a cells RIP140 expression in N2a-RIP 140 cells was remarkably upregulated at both the mRNA and protein levels.N2a-RIP 140 cells had a significantly increased percentage of cells baring neurites,and numbers of neurites per cell,as compared to N2a cells,in the absence and presence of RA (P < 0.05).In addition,Tuj l,a neuronal biomarker,was strongly upregulated in N2a-RIP140 cells (P < 0.05) and phosphorylated ERK1/2 (p-ERK1/2) levels in N2a-RIP140 cells were dramatically increased,while differentiation was inhibited by the ERK 1/2-specific

  13. X-ray Modeling of \\eta\\ Carinae and WR140 from SPH Simulations

    CERN Document Server

    Russell, Christopher M P; Okazaki, Atsuo T; Madura, Thomas I; Owocki, Stanley P

    2011-01-01

    The colliding wind binary (CWB) systems \\eta\\ Carinae and WR140 provide unique laboratories for X-ray astrophysics. Their wind-wind collisions produce hard X-rays that have been monitored extensively by several X-ray telescopes, including RXTE. To interpret these RXTE X-ray light curves, we model the wind-wind collision using 3D smoothed particle hydrodynamics (SPH) simulations. Adiabatic simulations that account for the absorption of X-rays from an assumed point source at the apex of the wind-collision shock cone by the distorted winds can closely match the observed 2-10keV RXTE light curves of both \\eta\\ Car and WR140. This point-source model can also explain the early recovery of \\eta\\ Car's X-ray light curve from the 2009.0 minimum by a factor of 2-4 reduction in the mass loss rate of \\eta\\ Car. Our more recent models relax the point-source approximation and account for the spatially extended emission along the wind-wind interaction shock front. For WR140, the computed X-ray light curve again matches the ...

  14. DHPC strongly affects the structure and oligomerization propensity of Alzheimer's Aβ(1-40) peptide.

    Science.gov (United States)

    Dahse, Kirsten; Garvey, Megan; Kovermann, Michael; Vogel, Alexander; Balbach, Jochen; Fändrich, Marcus; Fahr, Alfred

    2010-11-05

    Alzheimer's disease (AD) is thought to depend on the deleterious action of amyloid fibrils or oligomers derived from β-amyloid (Aβ) peptide. Out of various known Aβ alloforms, the 40-residue peptide Aβ(1-40) occurs at highest concentrations inside the brains of AD patients. Its aggregation properties critically depend on lipids, and it was thus proposed that lipids could play a major role in AD. To better understand their possible effects on the structure of Aβ and on the ability of this peptide to form potentially detrimental amyloid structures, we here analyze the interactions between Aβ(1-40) and 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC). DHPC has served, due to its controlled properties, as a major model system for studying general lipid properties. Here, we show that DHPC concentrations of 8 mM or higher exert dramatic effects on the conformation of soluble Aβ(1-40) peptide and induce the formation of β-sheet structure at high levels. By contrast, we find that DHPC concentrations well below the critical micelle concentration present no discernible effect on the conformation of soluble Aβ, although they substantially affect the peptide's oligomerization and fibrillation kinetics. These data imply that subtle lipid-peptide interactions suffice in controlling the overall aggregation properties and drastically accelerate, or delay, the fibrillation kinetics of Aβ peptide in near-physiological buffer solutions.

  15. A 140 GHz pulsed EPR/212 MHz NMR spectrometer for DNP studies

    Science.gov (United States)

    Smith, Albert A.; Corzilius, Björn; Bryant, Jeffrey A.; DeRocher, Ronald; Woskov, Paul P.; Temkin, Richard J.; Griffin, Robert G.

    2012-10-01

    We described a versatile spectrometer designed for the study of dynamic nuclear polarization (DNP) at low temperatures and high fields. The instrument functions both as an NMR spectrometer operating at 212 MHz (1H frequency) with DNP capabilities, and as a pulsed-EPR operating at 140 GHz. A coiled TE011 resonator acts as both an NMR coil and microwave resonator, and a double balanced (1H, 13C) radio frequency circuit greatly stabilizes the NMR performance. A new 140 GHz microwave bridge has also been developed, which utilizes a four-phase network and ELDOR channel at 8.75 GHz, that is then multiplied and mixed to obtain 140 GHz microwave pulses with an output power of 120 mW. Nutation frequencies obtained are as follows: 6 MHz on S = 1/2 electron spins, 100 kHz on 1H, and 50 kHz on 13C. We demonstrate basic EPR, ELDOR, ENDOR, and DNP experiments here. Our solid effect DNP results demonstrate an enhancement of 144 and sensitivity gain of 310 using OX063 trityl at 80 K and an enhancement of 157 and maximum sensitivity gain of 234 using Gd-DOTA at 20 K, which is significantly better performance than previously reported at high fields (⩾3 T).

  16. Near IR Spectroscopic monitoring of WR 140 during the 2001 periastron passage

    CERN Document Server

    Varricatt, W P; Ashok, N M

    2004-01-01

    We present new spectra of WR 140 (HD 193793) in the JHK bands with some covering the 1.083-micron He I emission line at higher resolution, observed between 2000 October and 2003 May to cover its 2001 periastron passage. The WC7 + O4-5 spectroscopic binary WR 140 is the prototype of colliding-wind, episodic dust-making Wolf-Rayet systems which also show strong variations in radio and X-ray emission. The JHK spectra showed changes in continuum and in the equivalent widths of the WC emission lines, consistent with formation of dust starting between 2001 January 3 and March 26 (orbital phases 0.989 and 0.017) and its subsequent fading and cooling. The 1.083-micron He I line has a P-Cygni profile which showed variations in both absorption and emission components as WR 140 went through periastron passage. The variation of the absorption component yielded tight constraints on the geometry of the wind-collision region, giving theta = 50 +/- 8 degrees for the opening semi-angle of the interaction `cone', indicating a ...

  17. A 140 GHz pulsed EPR/212 MHz NMR spectrometer for DNP studies.

    Science.gov (United States)

    Smith, Albert A; Corzilius, Björn; Bryant, Jeffrey A; DeRocher, Ronald; Woskov, Paul P; Temkin, Richard J; Griffin, Robert G

    2012-10-01

    We described a versatile spectrometer designed for the study of dynamic nuclear polarization (DNP) at low temperatures and high fields. The instrument functions both as an NMR spectrometer operating at 212 MHz ((1)H frequency) with DNP capabilities, and as a pulsed-EPR operating at 140 GHz. A coiled TE(011) resonator acts as both an NMR coil and microwave resonator, and a double balanced ((1)H, (13)C) radio frequency circuit greatly stabilizes the NMR performance. A new 140 GHz microwave bridge has also been developed, which utilizes a four-phase network and ELDOR channel at 8.75 GHz, that is then multiplied and mixed to obtain 140 GHz microwave pulses with an output power of 120 mW. Nutation frequencies obtained are as follows: 6 MHz on S=1/2 electron spins, 100 kHz on (1)H, and 50 kHz on (13)C. We demonstrate basic EPR, ELDOR, ENDOR, and DNP experiments here. Our solid effect DNP results demonstrate an enhancement of 144 and sensitivity gain of 310 using OX063 trityl at 80 K and an enhancement of 157 and maximum sensitivity gain of 234 using Gd-DOTA at 20 K, which is significantly better performance than previously reported at high fields (≥3 T).

  18. A Detailed Analysis of the Morphology of Fibrils of Selectively Mutated Amyloid β (1-40).

    Science.gov (United States)

    Adler, Juliane; Baumann, Monika; Voigt, Bruno; Scheidt, Holger A; Bhowmik, Debanjan; Häupl, Tilmann; Abel, Bernd; Madhu, Perunthiruthy K; Balbach, Jochen; Maiti, Sudipta; Huster, Daniel

    2016-09-05

    A small library of rationally designed amyloid β [Aβ(1-40)] peptide variants is generated, and the morphology of their fibrils is studied. In these molecules, the structurally important hydrophobic contact between phenylalanine 19 (F19) and leucine 34 (L34) is systematically mutated to introduce defined physical forces to act as specific internal constraints on amyloid formation. This Aβ(1-40) peptide library is used to study the fibril morphology of these variants by employing a comprehensive set of biophysical techniques including solution and solid-state NMR spectroscopy, AFM, fluorescence correlation spectroscopy, and XRD. Overall, the findings demonstrate that the introduction of significant local physical perturbations of a crucial early folding contact of Aβ(1-40) only results in minor alterations of the fibrillar morphology. The thermodynamically stable structure of mature Aβ fibrils proves to be relatively robust against the introduction of significantly altered molecular interaction patterns due to point mutations. This underlines that amyloid fibril formation is a highly generic process in protein misfolding that results in the formation of the thermodynamically most stable cross-β structure.

  19. Microstructure and dielectric properties of dysprosium-doped barium titanate ceramics Microestrutura e propriedades dielétricas de cerâmicas de titanato de bário dopado com disprósio

    Directory of Open Access Journals (Sweden)

    Y. Pu

    2005-09-01

    Full Text Available The substitution behavior and lattice parameter of barium titanate between solid_solubility with a dopant concentration in the range of 0.25 to 1.5 mol% are studied. The influences of dysprosium-doped fraction on the grain size and dielectric properties of barium titanate ceramic, including dielectric constant and breakdown electric field strength, are investigated via scanning electronic microscopy, X-ray diffraction and electric property tester. The results show that, at a dysprosium concentration of 0.75 mol%, the abnormal grain growth is inhibited and the lattice parameters of grain rise up to the maximum because of the lowest vacancy concentration. In addition, the finegrain and high density of barium titanate ceramic result in its excellent dielectric properties. The relative dielectric constant (25 °C reaches to 4100. The temperature coefficient of the capacitance varies from -10 to 10% within the temperature range of -15 °C -100 °C, and the breakdown electric field strength (alternating current achieves 3.2 kV/mm. These data suggest that our barium titanate could be used in the manufacture of high voltage ceramic capacitors.Foram estudados o comportamento da substituição e o parâmetro de rede de titanato de bário da solubilidade sólida com uma concentração de dopante na faixa 0,25-1,5 mol%. As influências da fração do dopante disprósio no tamanho de grão e nas propriedades dielétricas da cerâmica de titanato de bário, incluindo constante dielétrica e rigidez dielétrica foram investigadas por meio de microscopia eletrônica de varredura, difração de raios X e teste de propriedades elétricas. Os resultados mostram que a uma concentração de disprósio de 0,75 mol% o crescimento anormal de grão é inibido e os parâmetros de rede aumentam até um máximo devido a menor concentração de vacâncias. Além disso, as cerâmicas de grãos pequenos e alta densidade resultam em excelentes propriedades dielétricas. A

  20. Neodymium Dysprosium Modified Starch- coated Magnetic Fluid Preparation of Ferrite%淀粉包覆镝钕改性铁氧体磁性液体的制备

    Institute of Scientific and Technical Information of China (English)

    林穗云; 周育辉

    2011-01-01

    In this paper, in order to obtain the ferrite magnetic fluids of higher saturation magnetic intensity with simple technology, nanometer magnetite ( Fe3O4 ) particles ware prepared by chemical co - precipitation. And to a certain proportion of Dysprosium Neodymium ferrite magnetic fluids on the modification, we selected starch prepara- tion for the relief of water - based coating of rare earth iron oxide magnetic fluid composites. We also investigated the amount of Nd - Dy, the amount of coating agent, reaction temperature, coating temperature on the performance of the products and the effects of particle size, and its preliminary characterization was also performed . Through experiment,we summed up, under n (Fe) : [ n ( Nd3+ ) + n ( Dy3+ ) ] = 30:1 and n ( Fe3 + ) : n ( Fe2 + ) = 1.70 ~ 1. 75, the ratio for use of dysprosium and neodymium is n(Dy3+ ) : n(Nd3+ ) =4:1, 25%NH3 · H2O(A. R. ) as precipitating agent and pH value conditioner; the reacting system temperature was controlled in 35 ℃, and the pH value was adjusted to 9 ~ 11 ; the best dosage of starch as the relief is O. 0050g each 6OraL magnetic fluids, the temperature of surfactant was controlled in 50℃ and the pH value was adjusted to 2 ~ 3. In such system under the conditions of a water - based rare - earth compound Nd Dy Fe Magnetic, fluid magnetic oxygen was higher than or- dinary water- based ferrite.%为制备工艺简单且饱和磁化强度高的磁流体,本文采用化学共沉淀法制得了纳米磁性Fe304粒子.然后以一定比例的镝钕对铁氧体磁流体改性,选择淀粉为包覆剂制备水基稀土复合铁氧磁流体.考察了镝钕的用量、包覆剂的用量、反应温度、包覆温度等因素对产物粒径及性能的影响,并对其进行了初步的性能表征.实验总结出适宜的条件:在n(Fe):[n(Nd3+)+n(Dy3+)]=30:1,n(Fe3+):n(Fe2+)=1.70~1.75

  1. Temperature-Sensitive Mutants of Fujinami Sarcoma Virus: Tumorigenicity and Reversible Phosphorylation of the Transforming p140 Protein

    Science.gov (United States)

    Lee, Wen-Hwa; Bister, Klaus; Moscovici, Carlo; Duesberg, Peter H.

    1981-01-01

    Several clones of Fujinami sarcoma virus (FSV) isolated from a laboratory stock or from mutagenized virus were temperature sensitive (ts) in transformation of cells in culture. When shifted from the permissive (37°C) to the nonpermissive (41.5°C) temperature, the cellular phenotype reverted to normal within 2 h, but it required about 48 h at 37°C to revert back to the transformed morphology. A temperature-resistant (tr) FSV clone was isolated from a tumor of an animal. All ts mutants were tumorigenic in animals but induced tumors only after latent periods of 12 to 25 days, compared to 5 to 6 days with tr virus. The ts lesions of the FSV mutants affected 90% of the phosphorylation of the nonstructural, gag-related 140,000-kilodalton phosphoprotein coded by FSV (p140), but did not affect virus replication or the synthesis of p140. Upon shifting from the permissive to the nonpermissive temperature, p140 was 90% dephosphorylated with an approximate 32P half-life of 20 min. When shifted back to the permissive temperature, the preexisting p140 was rephosphorylated in the absence of protein synthesis within a 90-min test period. Likewise, most of the phosphate of fully phosphorylated p140 was exchanged at the permissive temperature within 30 to 90 min even when protein synthesis was inhibited. However, the protein structure of p140 had a half-life of 5 h at both temperatures. These results prove p140 to be a substrate of reversible phosphorylation. Superinfection and transformation of ts FSV-infected cells maintained at the nonpermissive temperature with acute leukemia virus MC29 failed to phosphorylate p140. It would follow that in vivo phosphorylation of ts p140 is controlled by an FSV-specific mechanism and is a prerequisite, not a consequence, of transformation. p140 of ts FSV recovered from cells maintained at 41.5°C with anti-gag serum was over 10 times less phosphorylated by associated kinase than the same protein recovered from cells at 37°C if assayed in

  2. Anti-HIV-1 Activity of Weekly or Biweekly Treatment with Subcutaneous PRO 140, a CCR5 Monoclonal Antibody

    Science.gov (United States)

    Jacobson, Jeffrey M.; Thompson, Melanie A.; Lalezari, Jacob P.; Saag, Michael S.; Zingman, Barry S.; D’Ambrosio, Paul; Stambler, Nancy; Rotshteyn, Yakov; Marozsan, Andre J.; Maddon, Paul J.; Morris, Stephen A.; Olson, William C.

    2010-01-01

    Background PRO 140 is a humanized CCR5 monoclonal antibody that has demonstrated potent antiviral activity when administered intravenously to adults infected with CCR5-tropic (R5) human immunodeficiency virus type 1 (HIV-1). This study is the first to evaluate subcutaneous (SC) administration. Methods A randomized, double-blind, placebo-controlled study was conducted in 44 subjects with HIV-1 RNA > 5,000 copies/mL, CD4+ cells > 300/μL, no antiretroviral therapy for ≥12 weeks, and only R5 HIV-1 detectable. Subjects received placebo, 162mg PRO 140, or 324mg PRO 140 weekly for three weeks or 324mg PRO 140 every other week for two doses by SC infusion. Subjects were monitored for 58 days for safety, antiviral effects and PRO 140 serum concentrations. Results SC PRO 140 demonstrated potent and prolonged antiretroviral activity. Mean log10 reductions in HIV-1 RNA were 0.23, 0.99 (p=0.0093), 1.37 (p=0.0001), and 1.65 (pPRO 140 offers the potential for significant dose-dependent HIV-1 RNA suppression and infrequent patient self-administration. Trial registration Clinicaltrials.gov register NCT00642707 PMID:20377413

  3. Vaccination-induced variation in the 140 kD merozoite surface antigen of Plasmodium knowlesi malaria

    OpenAIRE

    1987-01-01

    Immunity to 143/140 kD schizont antigens of a monkey malaria, Plasmodium knowlesi, provides partial protection to lethal malaria infection in rhesus monkeys challenged with uncloned parasites. To determine the capacity of a cloned parasite to generate variants of the 143/140 kD antigens, immunized monkeys were challenged with a clone of P. knowlesi. Parasites recovered 8 d after inoculation with a cloned parasite retained the 143/140 kD antigens. Parasites recovered 30 d after challenge had u...

  4. INFLUENCE OF SCATTERED NEUTRON RADIATION ON METROLOGICAL CHARACTERISTICS OF АТ140 NEUTRON CALIBRATION FACILITY

    Directory of Open Access Journals (Sweden)

    D. I. Komar

    2017-01-01

    Full Text Available Today facilities with collimated radiation field are widely used as reference in metrological support of devices for neutron radiation measurement. Neutron fields formed by radionuclide neutron sources. The aim of this research was to study characteristics of experimentally realized neutron fields geometries on АТ140 Neutron Calibration Facility using Monte Carlo method.For calibration, we put a device into neutron field with known flux density or ambient equivalent dose rate. We can form neutron beam from radionuclide fast-neutron source in different geometries. In containercollimator of АТ140 Neutron Calibration Facility we can install special inserts to gather fast-neutron geometry or thermal-neutron geometry. We need to consider neutron scattering from air and room’s walls. We can conduct measurements of neutron field characteristics in several points and get the other using Monte Carlo method.Thermal neutron collimator forms a beam from radionuclide source with a significant amount of neutrons with thermal energies. From found relationship between full neutron flux and distance to neutron source we see that inverse square law is violated. Scattered radiation contribution into total flux increases when we are moving away from neutron source and significantly influences neutron fields characteristics. While source is exposed in shadow-cone geometry neutron specter has pronounced thermal component from wall scattering.In this work, we examined main geometry types used to acquire reference neutron radiation using radionuclide sources. We developed Monte Carlo model for 238Pu-Be neutron source and АТ140 Neutron Calibration Facility’s container-collimator. We have shown the most significant neutron energy distribution factor to be scattered radiation from room’s walls. It leads to significant changes of neutron radiation specter at a distance from the source. When planning location, and installing the facility we should consider

  5. Geochronological constraints on 140-85 Ma thermal doming extension in the Dabie orogen, central China

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Regional architecture of geochronology and differential cooling pattern show that the Dabie orogen underwent a thermal doming extension during 140-85 Ma. This extension resulted in widespread re-melting of the Dabie basement, intense volcanic activities in North Huaiyang and the formation of fault-controlled depressions in the Hefei basin. This thermal doming extension can be further divided into two consecutive evolving stages, i.e. the intensifying stage (140-105 Ma) and the declining stage (105-85 Ma). In the first stage (140-105 Ma), the thermal doming mainly was concentrated in the Dabie block, and to a less degree, in the Hongan block. The thermal doming structure of the Dabie block is configured with Macheng-Yuexi thermal axis, Yuexi/Luotian thermal cores and their downslide flanks. The orientation of thermal axis is dominantly parallel to the strike of orogen, and UHP/HP units together with metamorphic rocks of North Huaiyang constitute the downslide flanks. The Yuexi core differs from the Luotian core in both the intensity and the shaping time. To some extent, the Hongan block can be regarded as part of downslide systems of the Dabie doming structure. The doming process is characterized by thermal-center's migration along the Macheng-Yuexi thermal axis; consequently, it is speculated to be attributed to the convective removal of thickened orogenic root, which is a process characterized by intermittance, migration, large-scale and differentiation. During the declining stage (105-85 Ma), the dome- shaped figure still structurally existed in the Dabie orogen, but orogenic units cooled remarkably slow and magmatic activities stagnated gradually. Study on the thermal doming of Dabieshan Mountains can thus provide detailed constraints on the major tectonic problems such as the UHP/HP exhumation model, the boundary between North Dabie and South Dabie, and the orogenesis mechanism.

  6. SU(2) Landau gluon propagator on a 140^3 lattice

    CERN Document Server

    Cucchieri, A; Taurines, A R; Cucchieri, Attilio; Mendes, Tereza; Taurines, Andre

    2003-01-01

    We present a numerical study of the gluon propagator in lattice Landau gauge for three-dimensional pure-SU(2) lattice gauge theory at couplings beta = 4.2, 5.0, 6.0 and for lattice volumes V = 40^3, 80^3, 140^3. In the limit of large V we observe a decreasing gluon propagator for momenta smaller than p_{dec} = 350^{+ 100}_{- 50} MeV. Data are well fitted by Gribov-like formulae and seem to indicate an infra-red critical exponent kappa slightly above 0.6, in agreement with recent analytic results.

  7. Implementation of a Dual on Die 140 V Super-Junction Power Transistors

    DEFF Research Database (Denmark)

    Nour, Yasser; Knott, Arnold; Jørgensen, Ivan Harald Holger

    Increasing the switching frequency for switch mode power supplies is one method to achieve smaller, lighter weight and hopefully cheaper power converters. Silicon is not only the dominant material used to produce the switches but also it allows more circuitry to be easily integrated on the same d....... This work presents an application customized switches to be used in switch mode power supplies. The prototype chip was implemented using a 0.18 μm SOI process and includes dual electrically isolated 140 V, 1.2 Ω N-channel MOSFETs....

  8. Gallium-67 scintigraphy and intraabdominal sepsis. Clinical experience in 140 patients with suspected intraabdominal abscess

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, G.B.; Kan, M.; Mende, C.W.

    1976-12-01

    In 140 patients with suspected intraabdominal abscess, studies were made using gallium-67 citrate and technetium-99m labeled radiopharmaceuticals. Gallium-67 scintigrams correctly localized 52 of 56 intraabdominal abscesses confirmed at surgical operation or necropsy. In an additional 20 patients in whom findings on scintigrams were abnormal, there were clinically established infections. Sixty-one patients in whom findings on scintigrams were normal were conservatively managed and discharged from the hospital; none proved to have an abscess. Four false-negative and three false-positive studies were recorded. Gallium-67 scintigraphy is a useful noninvasive diagnostic adjunct that should be employed early in the evaluation of patients with suspected intraabdominal sepsis.

  9. Molecular attenuation and phase dispersion between 40 and 140-GHz for path models from different altitudes

    Science.gov (United States)

    Liebe, H. J.; Welch, W. M.

    1973-01-01

    Radio wave propagation in the 40 to 140 GHz band through the first hundred kilometers of the atmosphere is strongly influenced by the microwave spectrum of oxygen (O2-MS). A unified treatment of molecular attenuation and phase dispersion is formulated. Results of molecular physics are translated into frequency, temperature, pressure, and magnetic field dependencies of a complex refractive index. The intensity distribution of the O2-MS undergoes several changes with increasing altitude. The influence of water vapor is discussed. Examples of computer plots are given as a function of altitude for homogeneous, zenith, and tangential path geometries. Molecular resonances of minor atmospheric gases are discussed briefly.

  10. New Gapless COS G140L Mode Proposed for Background-Limited Far-UV Observations

    CERN Document Server

    Redwine, Keith; Fleming, Brian; France, Kevin; Zheng, Wei; Osterman, Steven; Howk, J Christopher; Anderson, Scott F; Gaensicke, Boris T

    2016-01-01

    Here we describe the observation and calibration procedure for a new G140L observing mode for the Cosmic Origins Spectrograph (COS) aboard the Hubble Space Telescope (HST). This mode, CENWAV = 800, is designed to move the far-UV band fully onto the Segment A detector, allowing for more e cient ob- servation and analysis by simplifying calibration management between the two channels, and reducing the astigmatism in this wavelength region. We also de- scribe some of the areas of scientific interest for which this new mode will be especially suited.

  11. New Gapless COS G140L Mode Proposed for Background-limited Far-UV Observations

    Science.gov (United States)

    Redwine, Keith; McCandliss, Stephan R.; Zheng, Wei; Fleming, Brian; France, Kevin; Osterman, Steven; Howk, J. Christopher; Anderson, Scott F.; Gäensicke, Boris T.

    2016-10-01

    Here we describe the observation and calibration procedure for a new G140L observing mode for the Cosmic Origins Spectrograph (COS) on board the Hubble Space Telescope (HST). This mode, CENWAV = 800, is designed to move the far-UV band fully onto the Segment A detector, allowing for more efficient observation and analysis by simplifying calibration management between the two channels, and reducing the astigmatism in this wavelength region. We also describe some of the areas of scientific interest for which this new mode will be especially suited.

  12. Remote-Steering Antennas for 140 GHz Electron Cyclotron Heating of the Stellarator W7-X

    Directory of Open Access Journals (Sweden)

    Lechte C.

    2017-01-01

    Full Text Available For electron cyclotron resonance heating of the stellarator W7-X at IPP Greifswald, a 140 GHz/10 MW cw millimeter wave system has been built. Two out of 12 launchers will employ a remote-steering design. This paper describes the overall design of the two launchers, and design issues like input coupling structures, manufacturing of corrugated waveguides, optimization of the steering range, integration of vacuum windows, mitrebends and vacuum valves into the launchers, as well as low power tests of the finished waveguides.

  13. Genome Sequence of Staphylococcus pseudintermedius Strain E140, an ST71 European-Associated Methicillin-Resistant Isolate.

    Science.gov (United States)

    Moodley, Arshnee; Riley, Matthew C; Kania, Stephen A; Guardabassi, Luca

    2013-03-07

    We report the first genome sequence of the methicillin-resistant Staphylococcus pseudintermedius (MRSP) strain E140, isolated from a canine bite wound infection in Denmark. This strain represents the dominant clonal lineage associated with canine MRSP infections in Europe.

  14. The sensitivity of the Late Saalian (140 ka) and LGM (21 ka) Eurasian ice sheets to sea surface conditions

    Energy Technology Data Exchange (ETDEWEB)

    Colleoni, Florence [Centro Euro-Mediterraneo per i Cambiamenti Climatici, Bologna (Italy); UJF, CNRS, Laboratoire de Glaciologie et Geophysique de l' Environnement, Saint Martin d' Heres Cedex (France); Stockholm University, Department of Geological Sciences, Stockhlom (Sweden); Liakka, Johan [Stockholm University, Department of Meteorology, Stockholm (Sweden); Krinner, Gerhard; Peyaud, Vincent [UJF, CNRS, Laboratoire de Glaciologie et Geophysique de l' Environnement, Saint Martin d' Heres Cedex (France); Jakobsson, Martin [Stockholm University, Department of Geological Sciences, Stockhlom (Sweden); Masina, Simona [Centro Euro-Mediterraneo per i Cambiamenti Climatici, Istituto Nazionale di Geofisica e Vulcanologia, Bologna (Italy)

    2011-08-15

    This work focuses on the Late Saalian (140 ka) Eurasian ice sheets' surface mass balance (SMB) sensitivity to changes in sea surface temperatures (SST). An Atmospheric General Circulation Model (AGCM), forced with two preexisting Last Glacial Maximum (LGM, 21 ka) SST reconstructions, is used to compute climate at 140 and 21 ka (reference glaciation). Contrary to the LGM, the ablation almost stopped at 140 ka due to the climatic cooling effect from the large ice sheet topography. Late Saalian SST are simulated using an AGCM coupled with a mixed layer ocean. Compared to the LGM, these 140 ka SST show an inter-hemispheric asymmetry caused by the larger ice-albedo feedback, cooling climate. The resulting Late Saalian ice sheet SMB is smaller due to the extensive simulated sea ice reducing the precipitation. In conclusion, SST are important for the stability and growth of the Late Saalian Eurasian ice sheet. (orig.)

  15. Road and Street Centerlines, 140 West, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — , published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as '140 West'. The extent of these data is...

  16. Performance of a magnetized total absorption calorimeter between 15 GeV and 140 GeV

    CERN Document Server

    Holder, M; Devaux, B; Dorth, W; Dydak, F; Eisele, F; Flottmann, T; Geweniger, C; Grimm, M; Hepp, V; Kleinknecht, K; Knobloch, J; Maillard, J; May, J; Navarria, Francesco Luigi; Paar, H P; Palazzi, P; Peyaud, B; Rander, J; Savoy-Navarro, A; Schlatter, W D; Spahn, G; Steinberger, J; Suter, H; Tittel, K; Turlay, René; Wahl, H; Williams, E G H; Willutzki, H J; Wotschack, J

    1978-01-01

    The authors have calibrated a magnetized iron-scintillator sandwich calorimeter in a hadron beam, finding an energy resolution equal to 16% fwhm at 140 GeV with 4 cm sampling. The hadron energy resolution (fwhm/mean) improves as E/sup -1/2/ between 15 and 140 GeV. No effect due to the magnetic field was observed. Longitudinal and lateral shower containment were also investigated. (15 refs).

  17. First visual orbit for the prototypical colliding-wind binary WR 140

    CERN Document Server

    Monnier, J D; Pedretti, E; Millan-Gabet, R; Berger, J P; Traub, W; Schloerb, F P; Brummelaar, T ten; McAlister, H; Ridgway, S; Sturmann, L; Sturmann, J; Turner, N; Baron, F; Kraus, S; Tannirkulam, A; Williams, P M

    2011-01-01

    Wolf-Rayet stars represent one of the final stages of massive stellar evolution. Relatively little is known about this short-lived phase and we currently lack reliable mass, distance, and binarity determinations for a representative sample. Here we report the first visual orbit for WR 140(=HD193793), a WC7+O5 binary system known for its periodic dust production episodes triggered by intense colliding winds near periastron passage. The IOTA and CHARA interferometers resolved the pair of stars in each year from 2003--2009, covering most of the highly-eccentric, 7.9 year orbit. Combining our results with the recent improved double-line spectroscopic orbit of Fahed et al. (2011), we find the WR 140 system is located at a distance of 1.67 +/- 0.03 kpc, composed of a WR star with M_WR = 14.9 +/- 0.5 Msun and an O star with M_O = 35.9 +/- 1.3 Msun. Our precision orbit yields key parameters with uncertainties times 6 smaller than previous work and paves the way for detailed modeling of the system. Our newly measured ...

  18. The structure of low-lying states in ${}^{140}$Sm studied by Coulomb excitation

    CERN Document Server

    Klintefjord, M.; Görgen, A.; Bauer, C.; Bello Garrote, F.L.; Bönig, S.; Bounthong, B.; Damyanova, A.; Delaroche, J.P.; Fedosseev, V.; Fink, D.A.; Giacoppo, F.; Girod, M.; Hoff, P.; Imai, N.; Korten, W.; Larsen, A.C.; Libert, J.; Lutter, R.; Marsh, B.A.; Molkanov, P.L.; Naïdja, H.; Napiorkowski, P.; Nowacki, F.; Pakarinen, J.; Rapisarda, E.; Reiter, P.; Renstrøm, T.; Rothe, S.; Seliverstov, M.D.; Siebeck, B.; Siem, S.; Srebrny, J.; Stora, T.; Thöle, P.; Tornyi, T.G.; Tveten, G.M.; Van Duppen, P.; Vermeulen, M.J.; Voulot, D.; Warr, N.; Wenander, F.; De Witte, H.; Zielińska, M.

    2016-05-02

    The electromagnetic structure of $^{140}$Sm was studied in a low-energy Coulomb excitation experiment with a radioactive ion beam from the REX-ISOLDE facility at CERN. The $2^+$ and $4^+$ states of the ground-state band and a second $2^+$ state were populated by multi-step excitation. The analysis of the differential Coulomb excitation cross sections yielded reduced transition probabilities between all observed states and the spectroscopic quadrupole moment for the $2_1^+$ state. The experimental results are compared to large-scale shell model calculations and beyond-mean-field calculations based on the Gogny D1S interaction with a five-dimensional collective Hamiltonian formalism. Simpler geometric and algebraic models are also employed to interpret the experimental data. The results indicate that $^{140}$Sm shows considerable $\\gamma$ softness, but in contrast to earlier speculation no signs of shape coexistence at low excitation energy. This work sheds more light on the onset of deformation and collectivit...

  19. The decay of quadrupole-octupole $1^-$ states in $^{40}$Ca and $^{140}$Ce

    CERN Document Server

    Derya, V; Aumann, T; Bhike, M; Endres, J; Gooden, M; Hennig, A; Isaak, J; Lenske, H; Löher, B; Pietralla, N; Savran, D; Tornow, W; Werner, V; Zilges, A

    2016-01-01

    Background: Two-phonon excitations originating from the coupling of two collective one-phonon states are of great interest in nuclear structure physics. One possibility to generate low-lying $E1$ excitations is the coupling of quadrupole and octupole phonons. Purpose: In this work, the $\\gamma$-decay behavior of candidates for the $(2_1^+\\otimes 3_1^-)_{1^-}$ state in the doubly-magic nucleus $^{40}$Ca and in the heavier and semi-magic nucleus $^{140}$Ce is investigated. Methods: $(\\vec{\\gamma},\\gamma')$ experiments have been carried out at the High Intensity $\\gamma$-ray Source (HI${\\gamma}$S) facility in combination with the high-efficiency $\\gamma$-ray spectroscopy setup $\\gamma^3$ consisting of HPGe and LaBr$_3$ detectors. The setup enables the acquisition of $\\gamma$-$\\gamma$ coincidence data and, hence, the detection of direct decay paths. Results: In addition to the known ground-state decays, for $^{40}$Ca the decay into the $3^-_1$ state was observed, while for $^{140}$Ce the direct decays into the $2...

  20. Orbitally modulated dust formation by the WC7+O5 colliding-wind binary WR140

    CERN Document Server

    Williams, P M; Marston, A P; Moffat, A F J; Varricatt, W P; Dougherty, S M; Kidger, M R; Morbidelli, L; Tapia, M

    2009-01-01

    We present high-resolution infrared (2--18 micron) images of the archetypal periodic dust-making Wolf-Rayet binary system WR140 (HD 193793) taken between 2001 and 2005, and multi-colour (J -- [19.5]) photometry observed between 1989 and 2001. The images resolve the dust cloud formed by WR140 in 2001, allowing us to track its expansion and cooling, while the photometry allows tracking the average temperature and total mass of the dust. The combination of the two datasets constrains the optical properties of the dust. The most persistent dust features, two concentrations at the ends of a `bar' of emission to the south of the star, were observed to move with constant proper motions of 324+/-8 and 243+/-7 mas/y. Longer wavelength (4.68-micron and 12.5-micron) images shows dust emission from the corresponding features from the previous (1993) periastron passage and dust-formation episode. A third persistent dust concentration to the east of the binary (the `arm') was found to have a proper motion ~ 320 mas/y. Extr...

  1. Study of the soft dipole modes in 140Ce via inelastic scattering of 17O

    Science.gov (United States)

    Krzysiek, M.; Kmiecik, M.; Maj, A.; Bednarczyk, P.; Ciemała, M.; Fornal, B.; Grȩbosz, J.; Mazurek, K.; Mȩczyński, W.; Ziȩbliński, M.; Crespi, F. C. L.; Bracco, A.; Benzoni, G.; Blasi, N.; Boiano, C.; Bottoni, S.; Brambilla, S.; Camera, F.; Giaz, A.; Leoni, S.; Million, B.; Morales, A. I.; Nicolini, R.; Pellegri, L.; Riboldi, S.; Vandone, V.; Wieland, O.; De Angelis, G.; Napoli, D. R.; Valiente-Dobon, J. J.; Bazzacco, D.; Farnea, E.; Gottardo, A.; Lenzi, S.; Lunardi, S.; Mengoni, D.; Michelagnoli, C.; Recchia, F.; Ur, C.; Gadea, A.; Huyuk, T.; Barrientos, D.; Birkenbach, B.; Geibel, K.; Hess, H.; Reiter, P.; Steinbach, T.; Wiens, A.; Bürger, A.; Görgen, A.; Guttormsen, M.; Larsen, A. C.; Siem, S.

    2014-05-01

    The main aim of this study was a deeper understanding of the nuclear structure properties of the soft dipole modes in 140Ce, excited via inelastic scattering of weakly bound 17O projectiles. An important aim was to investigate the ‘splitting’ of the PDR into two parts: a low-energy isoscalar component dominated by neutron-skin oscillations and a higher-energy component lying on the tail of the giant dipole resonance of a rather isovector character. This was already observed for this nucleus, investigated in (α, α‧) and (γ, γ‧) experiments. The experiment was performed at Laboratori Nazionali di Legnaro, Italy. Inelastic scattering of 17O ion beam at 20 MeV A-1 was used to excite the resonance modes in the 140Ce target. Gamma-rays were registered by five triple clusters of AGATA-Demonstrator and nine large volume scintillators (LaBr3). The scattered 17O ions were identified by two ΔE - E Si telescopes of the TRACE array mounted inside the scattering chamber. The telescopes consisted of two segmented Si-pad detectors, each of 60 pixels. Very preliminary data have shown a strong domination of the E1 transitions in the ‘pygmy’ region with a character more similar to the one obtained in alpha scattering experiment.

  2. Finding the First Cosmic Explosions. IV. 90 - 140 M$_{\\odot}$ Pair-Instability Supernovae

    CERN Document Server

    Smidt, Joseph; Chatzopoulos, E; Wiggins, Brandon K; Chen, Ke-Jung; Kozyreva, Alexandra; Even, Wesley

    2014-01-01

    Population III stars that die as pair-instability supernovae are usually thought to fall in the mass range of 140 - 260 M$_{\\odot}$. But several lines of work have now shown that rotation can build up the He cores needed to encounter the pair instability at stellar masses as low as 90 $_{\\odot}$. Depending on the slope of the initial mass function of Population III stars, there could be 4 - 5 times as many stars from 90 - 140 $_{\\odot}$ in the primordial universe than in the usually accepted range. We present numerical simulations of the pair-instability explosions of such stars performed with the MESA, FLASH and RAGE codes. We find that they will be visible to supernova factories such as Pan-STARRS and LSST in the optical out to z $\\sim$ 1 - 2 and to JWST and the 30 m-class telescopes in the NIR out to $z \\sim$ 7 - 10. Such explosions will thus probe the stellar populations of the first galaxies and cosmic star formation rates in the era of cosmological reionization. These supernovae are also easily distingu...

  3. 早产儿贫血140例相关因素分析%Analysis of Relative Factors for Anemia in 140 Prematurity

    Institute of Scientific and Technical Information of China (English)

    丁晶; 刘捷; 曾超美

    2012-01-01

    目的 探讨早产儿贫血的发生及其相关因素.方法 对本院2009年1月-2010年12月收治的140例发生贫血的早产儿进行回顾性研究,分析早产儿贫血的好发时间及主要病因.并按发生贫血的时间,将早产儿分为早期贫血组和晚期贫血组,进行与贫血发生早晚有关的围生因素分析.结果 发生贫血的早产儿中95%的贫血发生在出生2周内,早期及晚期贫血组中分别有67.0%及82.7%的早产儿的贫血是由感染、失血共同引起.早期贫血组早产儿出生时的基础Hb值较晚期贫血组低[(154.0±17.2)g·L-1vs(177.0±11.6)g·L-1],差异有统计学意义(P<0.01),而早期贫血组早产儿初始出现贫血时平均红细胞体积较晚期贫血组高[(107.0±5.5)fLvs(105.0±5.4)fL],差异有统计学意义(P<0.05).结论 早产儿贫血大部分发生在出生2周内,通常为感染、失血多因素共同引起,且早产儿贫血发生的早晚与其出生时基础Hb密切相关.%Objective To investigate the development of anemia of prematurity and its related factors. Methods The medical data of 140 premature anemia infants admitted to Peking University People's Hospital from Jan. 2009 to Dec. 2010 were reviewed retrospectively. The infants were classified into 2 groups: early anemia group and late anemia group. Then the occurrence time and factors associated with the anemia of prematurity were identified. Results Ninety - five percent of the anemia of prematurity took place in the first 2 weeks after birth. Its development was usually caused by many factors together,such as infection and blood loss. The hemoglobin level,which was tested at birth,in the early anemia group was significantly lower than that in late anemia group [ ( 154. 0 ± 17. 2) g ? L-1 vs (177. 0 ± 11. 6) g ? L ,P < 0. 01 ]. While the mean corpuscular volume in the early anemia group preterm infants,which was tested when they began developing anemia, was greater than that in late anemia group

  4. 140 Cases of Infant Rotavirus Enteritis Disease Characteristics%婴幼儿轮状病毒性肠炎140例发病特点分析

    Institute of Scientific and Technical Information of China (English)

    张颖

    2013-01-01

    Objective The purpose of the 2009 to 2011 from our hospital 140 cases of infant rotavirus enteritis disease characteristics analysis to understand. Method Rotavirus enteritis in infants and young children from our hospital from January 2009 to November 2011 as the research object, doing a routine check of the specimens of the faeces of children with acute diarrhea, fecal occult blood test, bacterial culture and the detection of rotavirus. Investigate feeding in children less than one year old. Results The incidence of infants within the two-year-old is relatively high, especially in the 10 to 12-month incidence peak period. The terms of the merger pathogen growth rate of 24%, in the comparison between the degree of diarrhea in infants less than one year old with artiifcial feeding and breastfeeding, and the difference was statistically signiifcant. Conclusion Infant diarrhea in autumn and winter is caused by rotavirus, breastfed infants will reduce the degree of diarrhea caused by rotavirus. Rotavirus diarrhea when there is disorder of lfora, intestinal lfora should be adjusted, symptomatic treatment in order to achieve the best healing effect of treatment should avoid the abuse of antibiotics.%目的对2010年~2012年来自我院的140例婴幼儿轮状病毒性肠炎的发病特点分析了解。方法对2010年1月至2012年11月来自我院的轮状病毒性肠炎的婴幼儿为研究对象,对患儿急性腹泻的粪便做标本进行常规的检查,对大便潜血检查、细菌培养和轮状病毒的检测。对不到1周岁的患儿的喂养情况进行调查。结果2岁以内的婴幼儿发病率比较高,尤其在10~12月份的发病率是高峰期。合并条件致病菌的生长率高达24%,在1岁以内的婴儿腹泻的程度与人工喂养和母乳喂养之间进行比较,其差异具有统计学意义。结论婴幼儿在秋冬季的腹泻主要是轮状病毒所导致的,母乳喂养婴儿会降低轮状病毒所导致的腹泻程度

  5. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

    Science.gov (United States)

    Grasso, Silvia; Chapelle, Jennifer; Salemme, Vincenzo; Aramu, Simona; Russo, Isabella; Vitale, Nicoletta; Verdun di Cantogno, Ludovica; Dallaglio, Katiuscia; Castellano, Isabella; Amici, Augusto; Centonze, Giorgia; Sharma, Nanaocha; Lunardi, Serena; Cabodi, Sara; Cavallo, Federica; Lamolinara, Alessia; Stramucci, Lorenzo; Moiso, Enrico; Provero, Paolo; Albini, Adriana; Sapino, Anna; Staaf, Johan; Di Fiore, Pier Paolo; Bertalot, Giovanni; Pece, Salvatore; Tosoni, Daniela; Confalonieri, Stefano; Iezzi, Manuela; Di Stefano, Paola; Turco, Emilia; Defilippi, Paola

    2017-01-01

    The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a clear difference in survival. p140Cap dampens ERBB2-positive tumour cell progression, impairing tumour onset and growth in the NeuT mouse model, and counteracting epithelial mesenchymal transition, resulting in decreased metastasis formation. One major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. Our findings point to a specific role of p140Cap in curbing the aggressiveness of ERBB2-amplified breast cancers and suggest that, due to its ability to impinge on specific molecular pathways, p140Cap may represent a predictive biomarker of response to targeted anti-ERBB2 therapies. PMID:28300085

  6. Aggregation process of Aβ1-40 with non-Aβ amyloid component of α-synuclein

    Science.gov (United States)

    Eugene, Cindie; Mousseau, Normand

    2015-09-01

    Many neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, are characterized by the presence of amyloid fibers. Recently, attention has turned from the fibers to the early stages of oligomerization where toxicity could be highest. Here, we focus on the interactions between non-Aβ amyloid component of a-synuclein (NAC) and Aβ1-40, two proteins found in amyloid fibrils associated with Alzheimer's disease. We combine the coarse-grained OPEP potential with a Hamiltonian and temperature replica exchange molecular dynamics simulation (HT-REMD) to identify mechanisms leading to the formation of secondary structures promoting fibrillation. We observe that the propensity to form beta-sheet remains the same for Aβ1-40 whereas is decreases significantly for NAC. In particular, the 25-35 region of Aβ1-40 is a significant area of secondary structure stabilization with NAC. The ionic interactions between salt-bridge D23 and K28 in Aβ1-40 and K20 and E23 in NAC of the heterogeneous dimer are consistent with the salt-bridges found in NAC and Aβ1-40 homogenous dimers and allow us to see that these interactions don't necessarily dominate the interchain stabilizations. Our numerical simulation also show the formation of interaction between the early oligomer of NAC and Aβ1-40.

  7. Effect of Aβ1-40 on membrane permeability and intracellular free Ca2+ of nerve cells

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The effects of soluble and fibrillar Aβ1-40 on membrane permeability and intracellular free Ca2+ of nerve cells were investigated by the laser confocal microscopy. Results indicate that: i) Effects of soluble and fibrillar Aβ1-40 on cell membrane permeability are both concentration-de- pendent. Soluble Aβ1-40 increases membrane permeability only at concentration of 3 ?mol/L, while the toxic effect of fibrillar Aβ1-40 is much stronger, its evident effect begins from 1 ?mol/L. When its concentration rose to 3 ?mol/L, not only the membrane permeability increased, but also the nuclear membrane broke seriously. ii) Both soluble and fibrillar Aβ1-40 at high concentrations increased the intracellular free Ca2+, and the increased amplitudes are concentration-dependent. However, the fibrillar one induces the increase of intracellular Ca2+ much quicker and synchronously. These results indicate that some correlation exists between the neurotoxicity of high concentration soluble and fibrillar Aβ1-40 and the change of physico-chemical properties and intracellular Ca ion imbalance.

  8. p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.

    Science.gov (United States)

    Repetto, Daniele; Camera, Paola; Melani, Riccardo; Morello, Noemi; Russo, Isabella; Calcagno, Eleonora; Tomasoni, Romana; Bianchi, Federico; Berto, Gaia; Giustetto, Maurizio; Berardi, Nicoletta; Pizzorusso, Tommaso; Matteoli, Michela; Di Stefano, Paola; Missler, Markus; Turco, Emilia; Di Cunto, Ferdinando; Defilippi, Paola

    2014-01-22

    A major challenge in the neuroscience field is the identification of molecules and pathways that control synaptic plasticity and memory. Dendritic spines play a pivotal role in these processes, as the major sites of excitatory synapses in neuronal communication. Previous studies have shown that the scaffold protein p140Cap localizes into dendritic spines and that its knockdown negatively modulates spine shape in culture. However, so far, there is no information on its in vivo relevance. By using a knock-out mouse model, we here demonstrate that p140Cap is a key element for both learning and synaptic plasticity. Indeed, p140Cap(-/-) mice are impaired in object recognition test, as well as in LTP and in LTD measurements. The in vivo effects of p140Cap loss are presumably attenuated by noncell-autonomous events, since primary neurons obtained from p140Cap(-/-) mice show a strong reduction in number of mushroom spines and abnormal organization of synapse-associated F-actin. These phenotypes are most likely caused by a local reduction of the inhibitory control of RhoA and of cortactin toward the actin-depolymerizing factor cofilin. These events can be controlled by p140Cap through its capability to directly inhibit the activation of Src kinase and by its binding to the scaffold protein Citron-N. Altogether, our results provide new insight into how protein associated with dynamic microtubules may regulate spine actin organization through interaction with postsynaptic density components.

  9. Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.

    Directory of Open Access Journals (Sweden)

    Hugo Mouquet

    Full Text Available Understanding the antibody response to HIV-1 in humans that show broad neutralizing serologic activity is a crucial step in trying to reproduce such responses by vaccination. Investigating antibodies with cross clade reactivity is particularly important as these antibodies may target conserved epitopes on the HIV envelope gp160 protein. To this end we have used a clade B YU-2 gp140 trimeric antigen and single-cell antibody cloning methods to obtain 189 new anti-gp140 antibodies representing 51 independent B cell clones from the IgG memory B cells of 3 patients infected with HIV-1 clade A or B viruses and exhibiting broad neutralizing serologic activity. Our results support previous findings showing a diverse antibody response to HIV gp140 envelope protein, characterized by differentially expanded B-cell clones producing highly hypermutated antibodies with heterogenous gp140-specificity and neutralizing activity. In addition to their high-affinity binding to the HIV spike, the vast majority of the new anti-gp140 antibodies are also polyreactive. Although none of the new antibodies are as broad or potent as VRC01 or PG9, two clonally-related antibodies isolated from a clade A HIV-1 infected donor, directed against the gp120 variable loop 3, rank in the top 5% of the neutralizers identified in our large collection of 185 unique gp140-specific antibodies in terms of breadth and potency.

  10. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Science.gov (United States)

    2010-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director has...

  11. Structure of Mg2SiO4 glass up to 140 GPa

    Science.gov (United States)

    Prescher, C.; Prakapenka, V.; Wang, Y.; Skinner, L. B.

    2014-12-01

    The physical properties of melts at temperature and pressure conditions of the Earth's mantle have a fundamental influence on the chemical and thermal evolution of the Earth. However, direct investigations of melt structures at these conditions are experimentally very difficult or even impossible with current capabilities. In order to still be able to obtain an estimate of the structural behavior of melts at high pressures and temperatures, amorphous materials have been widely used as analogue materials. In particular the investigation of sound wave velocities of amorphous SiO2 and MgSiO3 as analogues for silicate melts indicate structural changes at about ~30-40 GPa and ~130-140 GPa [1]. The transition pressures are lower for MgSiO3 than for SiO2 indicating that these transitions are affected by the degree of polymerization of the SiO2 network of the glasses. Nevertheless, these measurements only give a hint about the occurrence of structural transitions but lack information on the actual structural changes accompanied by the sound wave velocity discontinuities. The pressure of the second structural transition at ~130-140 GPa is of vital importance for geophysics. If it causes silicate melts to become denser than the surrounding solid material, it would result in negatively buoyant melts close to the core-mantle boundary, which could be a major factor affecting the chemical stratification of the Earth's mantle during an early magma ocean after the moon forming impact. In order to resolve the structural transition and estimate the effect of a different degree of polymerization further, we studied the structural behavior of Mg2SiO4 glass up to 140 GPa using X-ray total scattering and pair distribution function analysis. The measurements were performed at the GSECARS 13-IDD beamline at the APS employing the newly developed multichannel collimator (MCC) setup. The MCC effectively removes unwanted Compton scattering of the diamond anvils and enables easy extraction of

  12. 表面修饰对镝铁氧体纳米磁粒子的合成及其磁性能的影响%Effect of Surface Modification on Formation and Magnetic Property of Dysprosium Ferrite Nanomagnetic Particles

    Institute of Scientific and Technical Information of China (English)

    陈静; 张茂润; 邓真娟

    2011-01-01

    利用湿化学法制备镝铁氧体纳米磁粒子时,用适量的阴离子表面活性剂进行表面修饰,能够有效地控制磁粒子的粒径,同时避免干燥时产生硬团聚.文章介绍了用月桂酸、月桂酸钠、正十二烷基硫酸钠对磁粒子进行表面修饰的研究结果,探讨了三者及其用量对磁粒子的形成及磁性能的影响.借助X射线衍射仪(XRD)、透射电镜(TEM)、振动样品磁强计(VSM)、红外光谱仪(IR)对产物的性能进行了表征.结果表明,用月桂酸修饰后的产物具有Fe3O4磁粒子的晶型结构且结晶度高、磁性能优异、平均粒径约16nm;用月桂酸钠、正十二烷基硫酸钠修饰后的产物不具有Fe3O4磁粒子的晶型结构,结晶度低且磁性能差.%When wet chemical method are use to prepare dysprosium-doped ferrite magnetic nanoparticles, right a-mount of anionic surfactant were doped as surface modification, which can effectively control the size of magnetic particles, and avoid producing hard reunion when dry out. This paper introduces the research results of magnetic particle surface modification by using lauric acid, laurel acid sodium and lauryl sodium sulfate, discusses the effect of lauric acid, laurel acid sodium and lauryl sodium sulfate and their dosages on the formation of magnetic and its magnetic property. The properties of the product can be characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), infrared spectrometer (IR). The results showed that the product modified with lauric acid have a crystalline structure of Fe3O4 magnetic particles and high crystallin-ity, excellent magnetic properties. The average particle size is about 16 nm; the product modified with laurel acid sodium and lauryl sodium sulfate does not have the crystalline structure of Fe3O4 magnetic particles, with low crystal-linity and low magnetic property.

  13. Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

    Directory of Open Access Journals (Sweden)

    Tomlinson Craig R

    2007-09-01

    Full Text Available Abstract Background The use of retinoids as anti-cancer agents has been limited due to resistance and low efficacy. The dynamics of nuclear receptor coregulation are incompletely understood. Cell-and context-specific activities of nuclear receptors may be in part due to distinct coregulator complexes recruited to distinct subsets of target genes. RIP140 (also called NRIP1 is a ligand-dependent corepressor that is inducible with retinoic acid (RA. We had previously shown that RIP140 limits RA induced tumor cell differentiation of embryonal carcinoma; the pluriopotent stem cells of testicular germ cell tumors. This implies that RIP140 represses key genes required for RA-mediated tumor cell differentiation. Identification of these genes would be of considerable interest. Results To begin to address this issue, microarray technology was employed to elucidate in a de novo fashion the global role of RIP140 in RA target gene regulation of embryonal carcinoma. Subclasses of genes were affected by RIP140 in distinct manners. Interestingly, approximately half of the RA-dependent genes were unaffected by RIP140. Hence, RIP140 appears to discriminate between different classes of RA target genes. In general, RIP140-dependent gene expression was consistent with RIP140 functioning to limit RA signaling and tumor cell differentiation. Few if any genes were regulated in a manner to support a role for RIP140 in "active repression". We also demonstrated that RIP140 silencing sensitizes embryonal carcinoma cells to low doses of RA. Conclusion Together the data demonstrates that RIP140 has profound effects on RA-mediated gene expression in this cancer stem cell model. The RIP140-dependent RA target genes identified here may be particularly important in mediating RA-induced tumor cell differentiation and the findings suggest that RIP140 may be an attractive target to sensitize tumor cells to retinoid-based differentiation therapy. We discuss these data in the context

  14. The decay pattern of the Pygmy Dipole Resonance of 140 Ce

    Energy Technology Data Exchange (ETDEWEB)

    Löher, B.; Savran, D.; Aumann, T.; Beller, J.; Bhike, M.; Cooper, N.; Derya, V.; Duchêne, M.; Endres, J.; Hennig, A.; Humby, P.; Isaak, J.; Kelley, J. H.; Knörzer, M.; Pietralla, N.; Ponomarev, V. Yu.; Romig, C.; Scheck, M.; Scheit, H.; Silva, J.; Tonchev, A. P.; Tornow, W.; Wamers, F.; Weller, H.; Werner, V.; Zilges, A.

    2016-05-01

    The decay properties of the Pygmy Dipole Resonance (PDR) have been investigated in the semi-magic N=82 nucleus 140Ce using a novel combination of nuclear resonance fluorescence and γ–γ coincidence techniques. Branching ratios for transitions to low-lying excited states are determined in a direct and model-independent way both for individual excited states and for excitation energy intervals. Comparison of the experimental results to microscopic calculations in the quasi-particle phonon model exhibits an excellent agreement, supporting the observation that the Pygmy Dipole Resonance couples to the ground state as well as to low-lying excited states. A 10% mixing of the PDR and the [21+×PDR] is extracted.

  15. The abundance of atomic carbon near the ionization fronts in M17 and S140

    Science.gov (United States)

    Keene, J.; Blake, G. A.; Phillips, T. G.; Huggins, P. J.; Beichman, C. A.

    1985-01-01

    The 492 GHz ground-state line of atomic carbon in the edge-on ionization fronts in M17 and S140 were observed. It was found that, contrary to expectation, the C I emission peaks farther into the molecular cloud from the ionization front than does the CO. In fact the peak C I abundance in M17 occurs more than 60 mag of visual extinction into the cloud from the ionization front. Calculations of the ratio of C I to CO column densities yield values of 0.1-0.2. These observations do not support chemical models which predict that neutral atomic carbon should be found only near the edges of molelcular clouds. Other models are discussed which may explain the observations.

  16. The decay pattern of the Pygmy Dipole Resonance of 140Ce

    Science.gov (United States)

    Löher, B.; Savran, D.; Aumann, T.; Beller, J.; Bhike, M.; Cooper, N.; Derya, V.; Duchêne, M.; Endres, J.; Hennig, A.; Humby, P.; Isaak, J.; Kelley, J. H.; Knörzer, M.; Pietralla, N.; Ponomarev, V. Yu.; Romig, C.; Scheck, M.; Scheit, H.; Silva, J.; Tonchev, A. P.; Tornow, W.; Wamers, F.; Weller, H.; Werner, V.; Zilges, A.

    2016-05-01

    The decay properties of the Pygmy Dipole Resonance (PDR) have been investigated in the semi-magic N = 82 nucleus 140Ce using a novel combination of nuclear resonance fluorescence and γ-γ coincidence techniques. Branching ratios for transitions to low-lying excited states are determined in a direct and model-independent way both for individual excited states and for excitation energy intervals. Comparison of the experimental results to microscopic calculations in the quasi-particle phonon model exhibits an excellent agreement, supporting the observation that the Pygmy Dipole Resonance couples to the ground state as well as to low-lying excited states. A 10% mixing of the PDR and the [21+ × PDR ] is extracted.

  17. 大块头和小不点——JOHN DEERE 7020和140

    Institute of Scientific and Technical Information of China (English)

    机械怪SHOW

    2009-01-01

    @@ 本期介绍给大家的模型是1:16比例的JOHN DEERE 7020和140,他们都是美国ERTL模型公司出品的金牌系列模型.从照片看的出,它们做工细腻,所有细节都得到了非常忠实的还原,是难得的收藏级别模型.由于它们体型悬殊,放到一起有着强烈的反差,于是就有了本期大块头和小不点的组合.

  18. Engaging Stakeholders through Twitter: How Nonprofit Organizations are Getting More Out of 140 Characters or Less

    CERN Document Server

    Lovejoy, Kristen; Saxton, Gregory D

    2011-01-01

    140 characters seems like too small a space for any meaningful information to be exchanged, but Twitter users have found creative ways to get the most out of each Tweet by using different communication tools. This paper looks into how 73 nonprofit organizations use Twitter to engage stakeholders not only through their tweets, but also through other various communication methods. Specifically, it looks into the organizations' utilization of tweet frequency, following behavior, hyperlinks, hashtags, public messages, retweets, and multimedia files. After analyzing 4,655 tweets, the study found that the nation's largest nonprofits are not using Twitter to maximize stakeholder involvement. Instead, they continue to use social media as a one-way communication channel, as less than 20% of their total tweets demonstrate conversations and roughly 16% demonstrate indirect connections to specific users.

  19. The paediatric flat foot and general anthropometry in 140 Australian school children aged 7 - 10 years

    Directory of Open Access Journals (Sweden)

    Evans Angela M

    2011-04-01

    Full Text Available Abstract Background Many studies have found a positive relationship between increased body weight and flat foot posture in children. Methods From a study population of 140 children aged seven to 10 years, a sample of 31 children with flat feet was identified by screening with the FPI-6. Basic anthropometric measures were compared between subjects with and without flat feet as designated. Results The results of this study, in contrast to many others, question the association of flat feet and heavy children. A significant relationship between foot posture and weight (FPI (L r = -0.186 (p Conclusions This study presents results which conflict with those of many previous investigations addressing the relationship between children's weight and foot posture. In contrast to previous studies, the implication of these results is that heavy children have less flat feet. Further investigation is warranted using a standardized approach to assessment and a larger sample of children to test this apparent contradiction.

  20. Gravity wave and tidal structures between 60 and 140 km inferred from space shuttle reentry data

    Science.gov (United States)

    Fritts, David C.; Wang, Ding-Yi; Blanchard, Robert C.

    1993-01-01

    This study presents an analysis of density measurements made using high-resolution accelerometers aboard several space shuttles at altitudes from 60 to 140 km during reentry into the earth's atmosphere. The observed density fluctuations are interpreted in terms of gravity waves and tides and provide evidence of the importance of such motions well into the thermosphere. Height profiles of fractional density variance reveal that wave amplitudes increase at a rate consistent with observations at lower levels up to about 90 km. The rate of amplitude growth decreases at greater heights, however, and appears to cease above about 110 km. Wave amplitudes are nevertheless large at these heights and suggest that gravity waves may play an important role in forcing of the lower thermosphere.

  1. Low Noise Amplifiers for 140 Ghz Wide-Band Cryogenic Receivers

    Science.gov (United States)

    Larkoski, Patricia V.; Kangaslahti, Pekka; Samoska, Lorene; Lai, Richard; Sarkozy, Stephen

    2013-01-01

    We report S-parameter and noise measurements for three different Indium Phosphide 35-nanometer-gate-length High Electron Mobility Transistor (HEMT) Low Noise Amplifier (LNA) designs operating in the frequency range centered on 140 gigahertz. When packaged in a Waveguide Rectangular-6.1 waveguide housing, the LNAs have an average measured noise figure of 3.0 decibels - 3.6 decibels over the 122-170 gigahertz band. One LNA was cooled to 20 degrees Kelvin and a record low noise temperature of 46 Kelvin, or 0.64 decibels noise figure, was measured at 152 gigahertz. These amplifiers can be used to develop receivers for instruments that operate in the 130-170 gigahertz atmospheric window, which is an important frequency band for ground-based astronomy and millimeter-wave imaging applications.

  2. Climatic variations in the past 140 ka recorded in core RM, east Qinghai-Xizang Plateau

    Institute of Scientific and Technical Information of China (English)

    吴敬禄; 王苏民; 潘红玺; 夏威岚

    1997-01-01

    The sequences of climatic evolution are reconstructed by the analyses of δ13C and δ18O of carbonate from core RM in the Zoige Basin since 140 kaB. P. During the Last Glaciation there existed at least seven warm climatic fluctuations and five cold events correlated with the records of ice core and deep sea, and during the preceding last in-terglacial period there were two cold climatic variations coinciding with the record of ice core GRIP. These results depict climatic instability in east Qinghai-Xizang Plateau over the last interglacial period. In addition, the environmental proxies of the carbonate content and pigments indicate the similar results to the stable isotope record from core RM.

  3. Development of a 402.5 MHz 140 kW Inductive Output Tube

    Energy Technology Data Exchange (ETDEWEB)

    R. Lawrence Ives; Michael Read, Robert Jackson

    2012-05-09

    This report contains the results of Phase I of an SBIR to develop a Pulsed Inductive Output Tube (IOT) with 140 kW at 400 MHz for powering H-proton beams. A number of sources, including single beam and multiple beam klystrons, can provide this power, but the IOT provides higher efficiency. Efficiencies exceeding 70% are routinely achieved. The gain is typically limited to approximately 24 dB; however, the availability of highly efficient, solid state drivers reduces the significance of this limitation, particularly at lower frequencies. This program initially focused on developing a 402 MHz IOT; however, the DOE requirement for this device was terminated during the program. The SBIR effort was refocused on improving the IOT design codes to more accurately simulate the time dependent behavior of the input cavity, electron gun, output cavity, and collector. Significant improvement was achieved in modeling capability and simulation accuracy.

  4. [HTLV-I retrovirus in Chile: study on 140 neurological patients].

    Science.gov (United States)

    Cartier, L; Araya, F; Castillo, J L; Verdugo, R; Mora, C; Gajdusek, D C; Gibbs, C J

    1990-06-01

    We screened 140 patients with different neurological diseases for the presence of anti HTLV-1 virus antibodies. ELISA test confirmed with Western Blot analysis was performed in CSF and blood. Positive findings were obtained in 23 out of 52 patients with progressive spastic paraparesis (44%). All patients with multiple sclerosis, polymyositis, amyotrophic lateral sclerosis or chronic polyneuropathy were negative. Patients with progressive spastic paraparesis and positive HTLV-1 antibodies were most commonly women (78%) and middle aged (mean 46 years old), with a history of surgical interventions (70%) or blood transfusion (35%). A slowly progressive spastic paraparesis with asymmetric onset and minimal sensory complaints was observed in some cases. Mononuclear pleocytosis in the CSF was observed in 35% with an increased IgG index in 88%. A delayed latency and low amplitude of somatosensory evoked potentials was observed in 89% of patients.

  5. Dose reconstruction for weapons experiments involving 140La at Los Alamos National Laboratory, 1944-1962.

    Science.gov (United States)

    Kraig, D H

    1997-10-01

    A series of 254 weapons design experiments was conducted by Los Alamos National Laboratory from 1944 through 1962 and resulted in the dispersal of approximately 11 PBq (300 kCi) of radioactive 140La. All shots occurred at Point Able in Bayo Canyon, east of the Los Alamos townsite. Public interest and the Government Accounting Office probe precipitated a dose reconstruction to assess potential exposures to members of the public. The information available for each shot included explosive charge size, date and time of explosion, and shot activity. Detailed meteorological data were not available for the majority of the shots, requiring the development of statistically representative meteorological data. A wind rose was developed specific to the afternoon-evening time of the shots, and the wind frequency in each sector was used to determine the fraction of activity dispersed towards each hypothetical receptor. HOTSPOT 7, a Gaussian plume-based dispersion model, was used to determine the average dose per sector per unit of shot activity. The dose from penetrating radiation from ground-deposited 140La was greater by several orders of magnitude than the dose from inhalation and immersion. The highest doses to a permanent resident probably occurred in the easternmost part of the Los Alamos townsite. The highest annual dose occurred in 1955 and was approximately 0.23 mSv. Assuming an individual had been at the location of maximum potential exposure in the Los Alamos townsite continuously throughout the experiments, the total dose from the 18-y series would have been approximately 1.4 mSv with an average dose of approximately 0.09 mSv y(-1). Doses at nearby Totavi trailer park, San Ildefonso Pueblo, and Santa Clara Pueblo were approximately 75%, 40%, and 15%, respectively, of those at Los Alamos. Visitors to nearby public areas received negligible doses.

  6. M1-M2 balancing act in white adipose tissue browning - a new role for RIP140.

    Science.gov (United States)

    Liu, Pu-Ste; Lin, Yi-Wei; Burton, Frank H; Wei, Li-Na

    2015-01-01

    A "Holy Grail" sought in medical treatment of obesity is to be able to biologically reprogram their adipose tissues to burn fat rather than store it. White adipose tissue (WAT) stores fuel and its expansion underlines insulin resistance (IR) whereas brown adipose tissue (BAT) burns fuel and stimulates insulin sensitivity. These two types of fats seesaw within our bodies via a regulatory mechanism that involves intricate communication between adipocytes and blood cells, particularly macrophages that migrate into adipose deposits. The coregulator, Receptor Interacting Protein 140 (RIP140), plays a key role in regulating this communication. In mice on a high-fat diet, the level of RIP140 in macrophages is dramatically elevated to activate their inflammatory M1 polarization and enhance their recruitment into WAT, facilitating IR. Conversely, lowering the level of RIP140 in macrophages not only reduces M1 macrophages but also expands alternatively polarized, anti-inflammatory M2 macrophages, triggering white adipose tissue browning, fat burning, and restoration of insulin sensitivity. This suggests a potential therapeutic strategy for reversing IR, obesity, and atherosclerotic or even cosmetic fat deposits: therapeutic browning of white adipose deposits by diminishing RIP140 levels in macrophages.

  7. Protective Effects of Vitamin E against Oxidative Damage Induced by Aβ1-40Cu(Ⅱ) Complexes

    Institute of Scientific and Technical Information of China (English)

    Xueling DAI; Yaxuan SUN; Zhaofeng JIANG

    2007-01-01

    β-amyloid peptide (Aβ) is considered to be responsible for the formation of senile plaques,which is the hallmark of Alzheimer's disease (AD). Oxidative stress, manifested by protein oxidation and lipid peroxidation, among other alterations, is a characteristic of AD brain. A growing body of evidence has been presented in support of Aβ1-40 forming an oligomeric complex that binds copper at a CuZn superoxide dismutase-like binding site. Aβ1-40Cu(Ⅱ) complexes generate neurotoxic hydrogen peroxide (H2O2) from O2 via Cu2+ reduction, though the precise reaction mechanism is unclear. Thc toxicity of Aβ1-40 or the Aβ1-40Cu(Ⅱ)complexes to cultured primary cortical neurons was partially attenuated when (+)-α-tocopherol (vitamin E)as free radical antioxidant was added at a concentration of 100 μM. The data derived from lactate dehydrogenase (LDH) release and the formation of H2O2 confirmed the results from the MTT assay. These findings indicate that copper binding to Aβ1-40 can give rise to greater production of H2O2, which leads to a breakdown in the integrity of the plasma membrane and subsequent neuronal death. Groups treated with vitamin E exhibited much slighter damage, suggesting that vitamin E plays a key role in protecting neuronal cells from dysfunction or death.

  8. Identification and cloning of the cDNA of a Rb-associated protein RAP140a

    Institute of Scientific and Technical Information of China (English)

    李权; 闻宏; 敖世洲

    2000-01-01

    Rb exerts important physiological functions in cell-cycle control, gene expression, cell differentiation, apoptosis, development and tumorigenesis by interacting with many cellular proteins. Using human partial Rb as bait, we screened a human fetal brain cDNA library through yeast two-hybrid system and obtained six novel cDNA fragments. Among them, one cDNA fragment corresponds to two different transcripts, 7 kb and 9 kb in Northern blot analysis. These two transcripts showed uniform distribution in various human tissues. We cloned the full-length cDNA of a 7.2 kb transcript through three times PCR amplifications. It was named RAP140a and predicted to encode a 1 233 amino acids hydrophilic protein. RAP140a was mapped to chromosome 3p13-p14.1. RAP140a may be functionally related to the intracellular translocation of Rb or other proteins.

  9. Identification and cloning of the cDNA of a Rb-associated protein RAP140a

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Rb exerts important physiological functions in cell-cycle control, gene expression, cell differentiation, apoptosis, development and tumorigenesis by interacting with many cellular proteins. Using human partial Rb as bait, we screened a human fetal brain cDNA library through yeast two-hybrid system and obtained six novel cDNA fragments. Among them, one cDNA fragment corre-sponds to two different transcripts, 7 kb and 9 kb in Northern blot analysis. These two transcripts showed uniform distribution in various human tissues. We cloned the full-length cDNA of a 7.2 kb transcript through three times PCR amplifications. It was named RAP140a and predicted to encode a 1 233 amino acids hydrophilic protein. RAP140a was mapped to chromosome 3p13-p14.1. RAP140a may be functionally related to the intracellular translocation of Rb or other proteins.

  10. Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate

    DEFF Research Database (Denmark)

    Visciano, Maria Luisa; Tagliamonte, Maria; Stewart-Jones, Guillaume

    2013-01-01

    broadened by possible structural modifications of the clade A gp14094UG018. Our results provide a rationale for the design and evaluation of immunogens and the clade A gp14094UG018 shows promising characteristics for potential involvement in an effective HIV vaccine with broad activity.......Trimeric soluble forms of HIV gp140 envelope glycoproteins represent one of the closest molecular structures compared to native spikes present on intact virus particles. Trimeric soluble gp140 have been generated by several groups and such molecules have been shown to induce antibodies...... with neutralizing activity against homologous and heterologous viruses. In the present study, we generated a recombinant trimeric soluble gp140, derived from a previously identified Ugandan A-clade HIV field isolate (gp14094UG018). Antibodies elicited in immunized rabbits show a broad binding pattern to HIV...

  11. The M7 October 21, 1868 Hayward Earthquake, Northern California-140 Years Later

    Science.gov (United States)

    Brocher, T. M.; Boatwright, J.; Lienkaemper, J. J.; Schwartz, D. P.; Garcia, S.

    2007-12-01

    October 21, 2008 marks the 140th anniversary of the M7 1868 Hayward earthquake. This large earthquake, which occurred slightly before 8 AM, caused extensive damage to San Francisco Bay Area and remains the nation's 12th most lethal earthquake. Property loss was extensive and about 30 people were killed. This earthquake culminated a decade-long series of earthquakes in the Bay Area which started with an M~6 earthquake in the southern Peninsula in 1856, followed by a series of four M5.8 to M6.1 sized earthquakes along the northern Calaveras fault, and ended with a M~6.5 earthquake in the Santa Cruz Mountains in 1865. Despite this flurry of quakes, the shaking from the 1868 earthquake was the strongest that the new towns and growing cities of the Bay Area had ever experienced. The effect on the brick buildings of the time was devastating: walls collapsed in San Francisco, Oakland, and San Jose, and buildings cracked as far away as Napa, Santa Rosa, and Hollister. The area that was strongly shaken (at Modified Mercalli Intensity VII or higher) encompassed about 2,300 km2. Aftershocks continued into November 1868. Surface cracking of the ground along the southern end of the Hayward Fault was traced from Warm Springs in Fremont northward 32 km to San Leandro. As Lawson (1908) reports, "the evidence to the northward of San Leandro is not very satisfactory. The country was then unsettled, and the information consisted of reports of cow- boys riding on the range". Analysis of historical triangulation data suggest that the fault moved as far north as Berkeley, and from these data the average slip along the fault is inferred to be about 1.9 ± 0.4 meters. The paleoseismic record from the southern end of the Hayward Fault provides evidence for 10 earthquakes before 1868. The average interval between these earthquakes is 170 ± 80 years, but the last five earthquakes have had an average interval of only 140 ± 50 years. The 1868 Hayward earthquake and more recent analogs such

  12. Twenty Years On!: Updating the IEA BESTEST Building Thermal Fabric Test Cases for ASHRAE Standard 140: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, R.; Neymark, J.

    2013-07-01

    ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs applies the IEA BESTEST building thermal fabric test cases and example simulation results originally published in 1995. These software accuracy test cases and their example simulation results, which comprise the first test suite adapted for the initial 2001 version of Standard 140, are approaching their 20th anniversary. In response to the evolution of the state of the art in building thermal fabric modeling since the test cases and example simulation results were developed, work is commencing to update the normative test specification and the informative example results.

  13. Early pulmonary involvement of anti-CADM-140 autoantibody-positive rapidly progressive interstitial lung disease preceding typical cutaneous symptoms.

    Science.gov (United States)

    Tamai, Koji; Tachikawa, Ryo; Otsuka, Kyoko; Ueda, Hiroyuki; Hosono, Yuji; Tomii, Keisuke

    2014-01-01

    We herein report a patient with clinically amyopathic dermatomyositis (CADM) who developed anti-CADM-140 autoantibody in association with rapidly progressive interstitial lung disease (RP-ILD). Chest high-resolution computed tomography (HRCT) revealed early pulmonary involvement preceding typical cutaneous lesions. Primary lesions of patchy peribronchial opacity developed ground-glass opacity and consolidation with architectural distortion and traction bronchiectasis. The possibility of anti-CADM-140 autoantibody-associated RP-ILD should be considered when patchy peribronchial opacity of an unknown cause is visible on chest HRCT.

  14. CCQM-K140: carbon stable isotope ratio delta values in honey

    Science.gov (United States)

    Dunn, P. J. H.; Goenaga-Infante, H.; Goren, A. C.; Şimşek, A.; Bilsel, M.; Ogrinc, N.; Armishaw, P.; Hai, L.

    2017-01-01

    As there can be small but measureable differences in isotope ratios between different sources of the same element/compound/material, isotope ratio measurements are applied in a number of different fields including archaeology, environmental science, geochemistry, forensic science and ecology. Isotope ratios for the light elements (H, C, N, O and S) are typically reported as δ-values which are isotope ratios expressed relative to an internationally agreed standard (this standard is the zero-point on the scale), although absolute isotope ratios which are traceable to the SI have also been reported. The IAWG has been granted a traceability exception for the use of arbitrary delta scales until SI traceability can be established at the required level of uncertainty but this goal is some years away. While the CCQM IAWG has previously organised several pilot studies on isotope ratio determination (CCQM-P75: Stable isotope delta values in methionine, 2006; CCQM-P105: Sr isotope ratios in wine, 2008; CCQM-K98: Pb isotope ratios in bronze with additional delta values in CCQM-P134, 2011), it has been a number of years since delta values of light elements have been considered and there has been no key comparison (KC). Therefore, the IAWG has included the need for a KC (CCQM-K140) based on an arbitrary delta scale in its program to support ongoing requirements to demonstrate core capabilities as well as specific claims of measurement capability (CMCs) in this area. The performance of all five of the CCQM-K140 participants was very good, illustrating their ability to obtain accurate results for carbon isotope ratios, within the calibration range afforded by internationally agreed reference materials (δ13CVPDB-LSVEC between ‑47.32 % and +535.3 %) with measurement uncertainties of between 0.08 and 0.28 %. This was despite the fact that no two participants used exactly the same approach in terms of instrumentation or data treatment. Main text To reach the main text of this

  15. Alzheimer's abeta(1-40) amyloid fibrils feature size-dependent mechanical properties.

    Science.gov (United States)

    Xu, Zhiping; Paparcone, Raffaella; Buehler, Markus J

    2010-05-19

    Amyloid fibrils are highly ordered protein aggregates that are associated with several pathological processes, including prion propagation and Alzheimer's disease. A key issue in amyloid science is the need to understand the mechanical properties of amyloid fibrils and fibers to quantify biomechanical interactions with surrounding tissues, and to identify mechanobiological mechanisms associated with changes of material properties as amyloid fibrils grow from nanoscale to microscale structures. Here we report a series of computational studies in which atomistic simulation, elastic network modeling, and finite element simulation are utilized to elucidate the mechanical properties of Alzheimer's Abeta(1-40) amyloid fibrils as a function of the length of the protein filament for both twofold and threefold symmetric amyloid fibrils. We calculate the elastic constants associated with torsional, bending, and tensile deformation as a function of the size of the amyloid fibril, covering fibril lengths ranging from nanometers to micrometers. The resulting Young's moduli are found to be consistent with available experimental measurements obtained from long amyloid fibrils, and predicted to be in the range of 20-31 GPa. Our results show that Abeta(1-40) amyloid fibrils feature a remarkable structural stability and mechanical rigidity for fibrils longer than approximately 100 nm. However, local instabilities that emerge at the ends of short fibrils (on the order of tens of nanometers) reduce their stability and contribute to their disassociation under extreme mechanical or chemical conditions, suggesting that longer amyloid fibrils are more stable. Moreover, we find that amyloids with lengths shorter than the periodicity of their helical pitch, typically between 90 and 130 nm, feature significant size effects of their bending stiffness due the anisotropy in the fibril's cross section. At even smaller lengths (50 nm), shear effects dominate lateral deformation of amyloid fibrils

  16. Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted rats.

    Science.gov (United States)

    Chen, YanFang; Chen, ShaoRui; Yue, ZhongBao; Zhang, YiQiang; Zhou, ChangHua; Cao, WeiWei; Chen, Xi; Zhang, LuanKun; Liu, PeiQing

    2017-02-01

    Heart failure (HF) is associated with myocardial energy metabolic abnormality. Receptor-interacting protein 140 (RIP140) is an important transcriptional cofactor for maintaining energy balance in high-oxygen consumption tissues. However, the role of RIP140 in the pathologic processes of HF remains to be elucidated. In this study, we investigated the role of RIP140 in mitochondrial and cardiac functions in rodent hearts under myocardial infarction (MI) stress. MI was created by a permanent ligation of left anterior descending coronary artery and exogenous expression of RIP140 by adenovirus (Ad) vector delivery. Four weeks after MI or Ad-RIP140 treatment, cardiac function was assessed by echocardiographic and hemodynamics analyses, and the mitochondrial function was determined by mitochondrial genes expression, biogenesis, and respiration rates. In Ad-RIP140 or MI group, a subset of metabolic genes changed, accompanied with slight reductions in mitochondrial biogenesis and respiration rates but no change in adenosine triphosphate (ATP) content. Cardiac malfunction was compensated. However, under MI stress, rats overexpressing RIP140 exhibited greater repressions in mitochondrial genes, state 3 respiration rates, respiration control ratio, and ATP content and had further deteriorated cardiac malfunction. In conclusion, RIP140 overexpression leads to comparable cardiac function as resulted from MI, but RIP140 aggravates metabolic repression, mitochondrial malfunction, and further accelerates the transition to HF in response to MI stress.

  17. Completion summary for boreholes USGS 140 and USGS 141 near the Advanced Test Reactor Complex, Idaho National Laboratory, Idaho

    Science.gov (United States)

    Twining, Brian V.; Bartholomay, Roy C.; Hodges, Mary K.V.

    2014-01-01

    In 2013, the U.S. Geological Survey, in cooperation with the U.S. Department of Energy, drilled and constructed boreholes USGS 140 and USGS 141 for stratigraphic framework analyses and long-term groundwater monitoring of the eastern Snake River Plain aquifer at the Idaho National Laboratory in southeast Idaho. Borehole USGS 140 initially was cored to collect continuous geologic data, and then re-drilled to complete construction as a monitor well. Borehole USGS 141 was drilled and constructed as a monitor well without coring. Boreholes USGS 140 and USGS 141 are separated by about 375 feet (ft) and have similar geologic layers and hydrologic characteristics based on geophysical and aquifer test data collected. The final construction for boreholes USGS 140 and USGS 141 required 6-inch (in.) diameter carbon-steel well casing and 5-in. diameter stainless-steel well screen; the screened monitoring interval was completed about 50 ft into the eastern Snake River Plain aquifer, between 496 and 546 ft below land surface (BLS) at both sites. Following construction and data collection, dedicated pumps and water-level access lines were placed to allow for aquifer testing, for collecting periodic water samples, and for measuring water levels. Borehole USGS 140 was cored continuously, starting from land surface to a depth of 543 ft BLS. Excluding surface sediment, recovery of basalt and sediment core at borehole USGS 140 was about 98 and 65 percent, respectively. Based on visual inspection of core and geophysical data, about 32 basalt flows and 4 sediment layers were collected from borehole USGS 140 between 34 and 543 ft BLS. Basalt texture for borehole USGS 140 generally was described as aphanitic, phaneritic, and porphyritic; rubble zones and flow mold structure also were described in recovered core material. Sediment layers, starting near 163 ft BLS, generally were composed of fine-grained sand and silt with a lesser amount of clay; however, between 223 and 228 ft BLS, silt

  18. Possibility analysis of combustion of torrefied biomass in 140 t/h PC boiler

    Directory of Open Access Journals (Sweden)

    Jagodzińska Katarzyna

    2016-01-01

    Full Text Available The study attempts to evaluate the impact of combustion of torrefied willow (Latin: Salix viminalis and palm kernel shell (Latin: Elaeis guineensis on the heat exchange in a 140 t/h PC boiler through an analysis of 6 cases for different boiler loads (60 %, 75 % and 100 % and a comparison with coal combustion. The analysis is premised on a 0-dimensional model based on the method presented in [15, 16, 17] and long-standing experimental measurements. Inter alia, the following results are presented: the temperature distribution of flue gases and the working medium (water/steam in characteristic points of the boiler as well as heat transfer coefficients for each element thereof. The temperature distribution of both fluids and the heat transfer coefficients are similar for all analysed fuels for each boiler load. However, the flue gas temperature at the outlet is higher in the case of torrefied biomass combustion. Due to that, there is an increase in the stack loss, which involves a decrease in the boiler efficiency. The conclusion is that torrefied biomass combustion is possible in a PC boiler without the need to change the boiler construction. However, it would be less effective than coal combustion.

  19. Unexpected High Brightness Temperature 140 PC from the Core in the Jet of 3C 120

    CERN Document Server

    Roca-Sogorb, Mar; Agudo, Ivan; Marscher, Alan P; Jorstad, Svetlana G

    2009-01-01

    We present 1.7, 5, 15, 22 and 43 GHz polarimetric multi--epoch VLBA observations of the radio galaxy 3C 120. The higher frequency observations reveal a new component, not visible before April 2007, located 80 mas from the core (which corresponds to a deprojected distance of 140 pc), with a brightness temperature about 600 times higher than expected at such distances. This component (hereafter C80) is observed to remain stationary and to undergo small changes in its brightness temperature during more than two years of observations. A combination of jet bending, significant flow acceleration, and a very strong shock --for such large distance from the core-- may explain the unusually high Tb of C80, but it seems very unlikely that this corresponds to the usual shock that emerges from the core and travels downstream to the location of C80. It appears that some other intrinsic process in the jet, capable of providing a local burst in particle and/or magnetic field energy, may be responsible for the enhanced bright...

  20. Retrospective evaluation of conservative treatment for 140 ingrown toenails with a novel taping procedure.

    Science.gov (United States)

    Watabe, Akiko; Yamasaki, Kenshi; Hashimoto, Akira; Aiba, Setsuya

    2015-09-01

    The aim of this study is retrospectively to review the efficacy of a taping procedure for treating ingrown toe-nails or for supporting other conservative treatments of ingrown toenails. A total of 140 ingrown toenails treated at the Dermatology Clinic in Tohoku University Hospital were retrospectively reviewed for demographic characteristics, association with granulation tissue or infection, treatment modalities and their outcomes, and classified according the treatment modalities. All the ingrown toe-nails were treated with a novel taping procedure, "slit tape-strap procedure" alone or in conjunction with other conservative treatments. The mean?±?SD duration until pain relief and until cure of the ingrown toenail were 4.8?±?4.7 days, range 0-24 and 21.0?±?11.2 weeks, range 4-56, respectively. All of the treatments were all effective, although 18 cases recurred after treatment. The "slit tape-strap procedure" is effective in treating ingrown toenails, either as a monotherapy or as a supportive therapy for other conservative treatments.

  1. Coulomb Excitation of Neutron-Rich $A\\approx$140 Nuclei

    CERN Multimedia

    Van duppen, P L E

    2002-01-01

    Investigating the isospin dependence of the product between the B( E2; 0$_{1}^{+} \\rightarrow 2_{1}^{+}$)-value and the 2$_{1}^{+}$-excitation energy E$_{2^{+}}$ in even-even nuclei around $A\\!\\approx$140 one observes a rather smooth trend close to the valley of stability but clear indication for a reduction from the extrapolated B(E2)-values by one order of magnitude for some very neutron-rich nuclei. While close to the valley of stability the strong neutron-proton interaction results in an equilibration of the neutron and proton deformations with a predominate isoscalar character of the collective 2$^{+}$ excitation, it is conceivable that more loosely bound neutrons cannot polarize a close-to-magic proton core that well any more. This might result in a decoupling of the shape of the outer neutrons from the core and in a strong isovector admixture to the lowest lying 2$^{+}$ level. In this way the 2$^{+}$ -energies could be further lowered in neutron-rich nuclei, while the quadrupole moments of the proton c...

  2. Structures of the Alzheimer's Wild-Type Aβ1-40 Dimer from Atomistic Simulations.

    Science.gov (United States)

    Tarus, Bogdan; Tran, Thanh T; Nasica-Labouze, Jessica; Sterpone, Fabio; Nguyen, Phuong H; Derreumaux, Philippe

    2015-08-20

    We have studied the dimer of amyloid beta peptide Aβ of 40 residues by means of all-atom replica exchange molecular dynamics. The Aβ-dimers have been found to be the smallest toxic species in Alzheimer's disease, but their inherent flexibilities have precluded structural characterization by experimental methods. Though the 24-μs-scale simulation reveals a mean secondary structure of 18% β-strand and 10% α helix, we find transient configurations with an unstructured N-terminus and multiple β-hairpins spanning residues 17-21 and 30-36, but the antiparallel and perpendicular peptide orientations are preferred over the parallel organization. Short-lived conformational states also consist of all α topologies, and one compact peptide with β-sheet structure stabilized by a rather extended peptide with α-helical content. Overall, this first all-atom study provides insights into the equilibrium structure of the Aβ1-40 dimer in aqueous solution, opening a new avenue for a comprehensive understanding of the impact of pathogenic and protective mutations in early-stage Alzheimer's disease on a molecular level.

  3. Project Frigonav hovercraft type 140 operating experience, February-March 1987

    Energy Technology Data Exchange (ETDEWEB)

    Jones, D.

    1987-01-01

    The area around Chicoutimi, Quebec is supplied with fuel from storage tanks normally supplied by ships coming up the Saguenay River. However, navigation is limited in winter when the river freezes, due to inability of icebreakers to navigate the shallow river, and fuel must be brought in by truck. A project was instigated to evaluate the possibility of clearing a channel between the oil pier and deep water by hovercraft, thereby providing a less costly alternative to moving fuel by road in the winter. An Airtrek 140 hovercraft, gross weight 7 tonnes, was chosen as a suitable machine for the task. Field trials were conducted to evaluate the performance of this craft at clearing the 30-70 cm ice along the navigation route. Some initial problems were encountered with the craft systems resulting from the extreme cold and contaminated fuel, but the overall test program was successful. A 300-m wide path 1.5 km long was cleared in 3 hours. A modified version of the craft, with additional power and ice impact protection, was recommended for future tests. 4 figs.

  4. Response of human HTB140 melanoma cells to conventional radiation and hadrons.

    Science.gov (United States)

    Ristić-Fira, A; Todorović, D; Zakula, J; Keta, O; Cirrone, P; Cuttone, G; Petrović, I

    2011-01-01

    Conventional radiotherapy with X- and gamma-rays is one of the common and effective treatments of cancer. High energy hadrons, i.e., charged particles like protons and (12)C ions, due to their specific physics and radiobiological advantages are increasingly used. In this study, effectiveness of different radiation types is evaluated on the radio-resistant human HTB140 melanoma cells. The cells were irradiated with gamma-rays, the 62 MeV protons at the Bragg peak and in the middle of the spread-out Bragg peak (SOBP), as well as with the 62 MeV/u (12)C ions. The doses ranged from 2 to 24 Gy. Cell survival and proliferation were assessed 7 days after irradiation, whereas apoptosis was evaluated after 48 h. The acquired results confirmed the high radio-resistance of cells, showing better effectiveness of protons than gamma-rays. The best efficiency was obtained with (12)C ions due to higher linear energy transfer. All analyzed radiation qualities reduced cell proliferation. The highest proliferation was detected for (12)C ions because of their large killing capacity followed by small induction of reparable lesions. This enabled unharmed cells to preserve proliferative activity. Irradiations with protons and (12)C ions revealed similar moderate pro-apoptotic ability that is in agreement with the level of cellular radio-resistance.

  5. [Male breast cancer in Morocco: Epidemiology and prognostic factors. A report of 140 cases].

    Science.gov (United States)

    Alaoui Slimani, K; Debbagh, A; Sbitti, Y; Errihani, H; Ichou, M

    2016-11-01

    Male breast cancer is rare; it constitutes 0.2-1.5 % of all malignant tumors in men and 1 % of all breast cancers. The goal of this retrospective study is to analyze the epidemiologic, clinic, therapeutic and evolutive profiles of this disease in 140 cases collected at the National Institute of Oncology and military hospital in Rabat, Morocco, between the years 1998 and 2007. The mean age was 61 years. A high incidence of overweight was found. The most frequent clinical presentation was a firm subareolar lump in 83 % of cases. The most common pathological type was an infiltrating ductal carcinoma (93 %). Hormone receptors were positive in 86 % of cases. Eighty-five percent of patients underwent simple mastectomy and axillary dissection, 68 % chest wall irradiation after surgery, 54 % received chemotherapy and 82 % hormonal therapy. Median follow-up was 91.1 months. The estimated 5-year and 10-year overall survival was respectively 68 % and 74 %. The management of male and female breast carcinoma is the same, as well as their prognosis at equal stages. Future research for better understanding of this disease are needed to improve the management and prognosis of male patients. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  6. Nanoscale structure and spectroscopic probing of Aβ1-40 fibril bundle formation

    Science.gov (United States)

    Psonka-Antonczyk, Katarzyna; Hammarström, Per; Johansson, Leif; Lindgren, Mikael; Stokke, Bjørn Torger; Nilsson, Peter; Nyström, Sofie

    2016-11-01

    Amyloid plaques composed of fibrillar Amyloid-β (Aβ) is a hallmark of Alzheimer’s disease. However, Aβ fibrils are morphologically heterogeneous. Conformation sensitive luminescent conjugated oligothiophenes (LCOs) are versatile tools for monitoring such fibril polymorphism in vivo and in vitro. Biophysical methods applied on in vitro generated Aβ fibrils, stained with LCOs with different binding and fluorescence properties, can be used to characterize the Aβ fibrillation in depth, far beyond that possible for in vivo generated amyloid plaques. In this study, in vitro fibrillation of the Aβ1-40 peptide was monitored by time-lapse transmission electron microscopy, LCO fluorescence and atomic force microscopy. Differences in the LCO binding in combination with nanoscale imaging revealed that spectral variation correlated with fibrils transforming from solitary filaments (Ø 2.5 nm) into higher order bundled structures (Ø 5 nm). These detailed in vitro experiments can be used to derive data that reflects the heterogeneity of in vivo generated Aβ plaques observed by LCO fluorescence. Our work provides new structural basis for targeted drug design and molecular probe development for amyloid imaging.

  7. Search for excited leptons in $e^{+} e^{-}$ annihilation at $\\sqrt {s}$ = 130 - 140 GeV

    CERN Document Server

    Acciarri, M; Adriani, O; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bencze, G L; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Bujak, A T; Burger, J D; Burger, W J; Burgos, C; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, C; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chéreau, X J; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coan, T E; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Commichau, V; Costantini, S; Cotorobai, F; de la Cruz, B; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Dénes, E; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabbretti, R; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Felcini, Marta; Ferguson, T; Fernández, D; Fernández, G; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Gailloud, M; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; González, E; Gougas, Andreas; Goujon, D; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gustafson, H R; Gutay, L J; Hangarter, K; Hartmann, B; Hasan, A; He, J T; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Koffeman, E; Köngeter, A; Koutsenko, V F; Koulbardis, A; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lindemann, B; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Maolinbay, M; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Möller, M; Monteleoni, B; Moore, R; Morganti, S; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Redaelli, M; Ren, D; Rescigno, M; Reucroft, S; Ricker, A; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Salicio, J M; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schulte, R; Schultze, K; Schwenke, J; Schwering, G; Sciacca, C; Seiler, P G; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Toker, O; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tsaregorodtsev, A Yu; Tully, C; Tuchscherer, H; Tung, K L; Ulbricht, J; Urbàn, L; Uwer, U; Valente, E; Van de Walle, R T; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vuilleumier, L; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Weill, R; Willmott, C; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zaccardelli, C; Zalite, A; Zemp, P; Zeng, J Y; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, G J; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino; Van der Zwaan, B C C

    1996-01-01

    We report on a search for the excited leptons e^*,mu^*,tau^* and nu^* in e+e- collisions at sqrt{s} = 130 - 140 GeV using the L3 detector at LEP. No evidence has been found for their existence. From an analysis of the expected pair produced l^*l^* in the channels e.e.gamma.gamma, mu.mu.gamma.gamma, tau.tau.gamma.gamma, eeWW, and nu.nu.gamma.gamma, we determine the lower mass limits at 95% C.L. of 64.7 GeV for e^*, 64.9 GeV for mu^*, 64.2 GeV for tau*, 57.3 GeV ( eW decay mode) and 61.4 GeV ( nu.gamma decay mode) for nu^*. From an analysis of the expected singly produced l.l^* in the channels e.e.gamma, mu.mu.gamma, tau.tau.gamma, nu.eW and nu.nu.gamma, we determine upper limits on the couplings lambda/m_{l^*} up to m_{l^*} = 130 GeV.

  8. Thermal neutron capture cross-section and resonance integral measurements of {sup 139}La(n, γ){sup 140}La and {sup 140}Ce(n, γ){sup 141}Ce using a Am-Be neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Panikkath, Priyada; Mohanakrishnan, P. [Manipal University, Manipal Centre for Natural Sciences, Karnataka (India)

    2017-03-15

    Thermal neutron capture cross-sections and resonance integrals of {sup 139}La(n, γ){sup 140}La and {sup 140}Ce (n, γ){sup 141}Ce are measured with respect to reference reactions {sup 197}Au(n, γ){sup 198}Au and {sup 55}Mn(n, γ){sup 56}Mn using the neutron activation technique. Measurements are carried out using neutrons from an Am-Be source located inside a concrete bunker. Two different methods are used for determining self-shielding factors of activation foils as well as for finding the epithermal neutron spectrum shape factor. For {sup 139}La with reference to {sup 197}Au and {sup 55}Mn the measured thermal cross sections are 9.24 ± 0.25 b and 9.28 ± 0.37 b, respectively, while the measured resonance integrals are 12.18 ± 0.67 b and 11.81 ± 0.94 b, respectively. For {sup 140}Ce with reference to {sup 197}Au and {sup 55}Mn the measured thermal cross sections are 0.44 ± 0.01 b and 0.44 ± 0.02 b, respectively, while the measured resonance integrals are 0.55 ± 0.03 b and 0.54 ± 0.04 b, respectively. The present measurements are compared with earlier measurements and evaluations. Presently estimated values confirm the established {sup 139}La(n, γ){sup 140}La cross-sections. The presently measured thermal capture cross-section {sup 140}Ce(n, γ){sup 141}Ce, though lower than the evaluated data, is having higher accuracy compared to previous measurements with large uncertainties. The resonance integral measured is higher (like most previous measurements) than most evaluations requiring a revision of the evaluated data. (orig.)

  9. Thermal neutron capture cross-section and resonance integral measurements of 139La(n, γ)140La and 140Ce(n, γ)141Ce using a Am-Be neutron source

    Science.gov (United States)

    Panikkath, Priyada; Mohanakrishnan, P.

    2017-03-01

    Thermal neutron capture cross-sections and resonance integrals of 139La(n, γ)140La and 140Ce (n, γ)141Ce are measured with respect to reference reactions 197Au(n, γ)198Au and 55Mn(n, γ)56Mn using the neutron activation technique. Measurements are carried out using neutrons from an Am-Be source located inside a concrete bunker. Two different methods are used for determining self-shielding factors of activation foils as well as for finding the epithermal neutron spectrum shape factor. For 139 La with reference to 197 Au and 55 Mn the measured thermal cross sections are 9.24 ± 0.25 b and 9.28 ± 0.37 b, respectively, while the measured resonance integrals are 12.18 ± 0.67 b and 11.81 ± 0.94 b, respectively. For 140 Ce with reference to 197 Au and 55 Mn the measured thermal cross sections are 0.44 ± 0.01 b and 0.44 ± 0.02 b, respectively, while the measured resonance integrals are 0.55 ± 0.03 b and 0.54 ± 0.04 b, respectively. The present measurements are compared with earlier measurements and evaluations. Presently estimated values confirm the established 139La(n, γ)140La cross-sections. The presently measured thermal capture cross-section 140Ce(n, γ)141Ce , though lower than the evaluated data, is having higher accuracy compared to previous measurements with large uncertainties. The resonance integral measured is higher (like most previous measurements) than most evaluations requiring a revision of the evaluated data.

  10. Bottom water oxygenation history in southeastern Arabian Sea during the past 140 ka: Results from redox-sensitive elements

    Digital Repository Service at National Institute of Oceanography (India)

    Pattan, J.N.; Pearce, N.J.G.

    history throughout the past 140 ka. The enrichment of redox-sensitive elements (Re, U, Cd and Sb) above average crustal abundances suggests that the Last Glacial Maxima (17.48 ka), stadials of Marine Isotope Stage (MIS)-5 (5b and 5d) and Glacial...

  11. 31 CFR 103.140 - Anti-money laundering programs for dealers in precious metals, precious stones, or jewels.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Anti-money laundering programs for... FOREIGN TRANSACTIONS Anti-Money Laundering Programs Anti-Money Laundering Programs § 103.140 Anti-money...) Anti-money laundering program requirement. (1) Each dealer shall develop and implement a written anti...

  12. 41 CFR 102-75.140 - In addition to the title report, and all necessary environmental information and certifications...

    Science.gov (United States)

    2010-07-01

    ... report, and all necessary environmental information and certifications, what information must an Executive agency transmit with the Report of Excess Real Property (Standard Form 118)? 102-75.140 Section... environmental information and certifications, what information must an Executive agency transmit with the...

  13. Changing the "Normal Range" for Blood Pressure from 140/90 to 130/Any Improves Risk Assessment.

    Science.gov (United States)

    Fulks, Michael; Stout, Robert L; Dolan, Vera F

    2015-01-01

    Objective .- Redefine the "normal" reference range for blood pressure from <140/90 to one that more effectively identifies individuals with increased mortality risk. Method .- Data from the recently published 2014 CRL blood pressure study was used. It includes 2,472,706 life insurance applicants tested by Clinical Reference Laboratory from 1993 to 2007 with follow-up for vital status using the September 2011 Social Security Death Master File. Various upper limits of blood pressure (BP in mm Hg) were evaluated to determine if any was superior to the current, commonly used limit of 140/90 in identifying individuals with increased mortality risk. Results .- An alternative reference range using a systolic BP (SBP) <130 with any diastolic BP (DBP) included 84% of life insurance applicants. It had a lower mortality rate and narrower range of relative risk than <140/90, including 89% as many applicants but only 68% as many deaths. This pattern of lives and deaths was consistent across age and sex. Conclusion .- Switching to a "normal" reference range of SBP <130 offers superior risk assessment relative to using BP <140/90 while still including a sufficient percentage of the population.

  14. Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death

    NARCIS (Netherlands)

    Bruinsma, I.B.; Wilhelmus, M.M.; Kox, M.; Veerhuis, R.; Waal, R.M.W. de; Verbeek, M.M.

    2010-01-01

    Cerebral amyloid angiopathy (CAA) is a common pathological finding in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis of the Dutch type; in this latter condition it is caused by deposition of mutated amyloid beta protein (Abeta Glu22Gln; D-Abeta(1-40)). Previously, we found a

  15. 10 CFR 140.107 - Appendix G-Form of indemnity agreement with licensees processing plutonium for use in plutonium...

    Science.gov (United States)

    2010-01-01

    ... processing plutonium for use in plutonium processing and fuel fabrication plants and furnishing insurance... § 140.107 Appendix G—Form of indemnity agreement with licensees processing plutonium for use in plutonium processing and fuel fabrication plants and furnishing insurance policies as proof of...

  16. 抗栓酶-3号对血小板α-颗粒膜蛋白140的影响

    Institute of Scientific and Technical Information of China (English)

    顾维新

    1995-01-01

    血小板α-颗粒膜蛋白140(GMP-140)是一种新的粘附蛋白分子,其分子量为140KD,也是中性粒细胞受体。它存在于血小板的α颗粒和血管内皮细胞内Weibel-palade小体的颗粒膜蛋白以及巨核细胞内。

  17. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.

    Science.gov (United States)

    Jayaraman, Anusha; Christensen, Amy; Moser, V Alexandra; Vest, Rebekah S; Miller, Chris P; Hattersley, Gary; Pike, Christian J

    2014-04-01

    The decline in testosterone levels in men during normal aging increases risks of dysfunction and disease in androgen-responsive tissues, including brain. The use of testosterone therapy has the potential to increase the risks for developing prostate cancer and or accelerating its progression. To overcome this limitation, novel compounds termed "selective androgen receptor modulators" (SARMs) have been developed that lack significant androgen action in prostate but exert agonist effects in select androgen-responsive tissues. The efficacy of SARMs in brain is largely unknown. In this study, we investigate the SARM RAD140 in cultured rat neurons and male rat brain for its ability to provide neuroprotection, an important neural action of endogenous androgens that is relevant to neural health and resilience to neurodegenerative diseases. In cultured hippocampal neurons, RAD140 was as effective as testosterone in reducing cell death induced by apoptotic insults. Mechanistically, RAD140 neuroprotection was dependent upon MAPK signaling, as evidenced by elevation of ERK phosphorylation and inhibition of protection by the MAPK kinase inhibitor U0126. Importantly, RAD140 was also neuroprotective in vivo using the rat kainate lesion model. In experiments with gonadectomized, adult male rats, RAD140 was shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy as demonstrated by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate. These novel findings demonstrate initial preclinical efficacy of a SARM in neuroprotective actions relevant to Alzheimer's disease and related neurodegenerative diseases.

  18. A distal 140 kyr sediment record of Nile discharge and East African monsoon variability

    Science.gov (United States)

    Ehrmann, Werner; Schmiedl, Gerhard; Seidel, Martin; Krüger, Stefan; Schulz, Hartmut

    2016-03-01

    Clay mineral assemblages in a sediment core from the distal Nile discharge plume off Israel have been used to reconstruct the late Quaternary Nile sediment discharge into the eastern Mediterranean Sea (EMS). The record spans the last ca. 140 kyr. Smectite abundances indicate the influence of the Blue Nile and the Atbara River that have their headwaters in the volcanic rocks of the Ethiopian Highlands. Kaolinite abundances indicate the influence of wadis, which contribute periodically to the suspension load of the Nile. Due to the geographical position, the climate and the sedimentary framework of the EMS is controlled by two climate systems. The long-term climate regime was governed by the African monsoon that caused major African humid periods (AHPs) with enhanced sediment discharge at 132 to AHP 5), 116 to 99 (AHP4), and 89 to 77 ka (AHP3). They lasted much longer than the formation of the related sapropel layers S5 (> 2 kyr), S4 (3.5 kyr), and S3 (5 kyr). During the last glacial period (Marine Isotope Stages (MISs) 4-2), the long-term changes in the monsoonal system were superimposed by millennial-scale changes in an intensified midlatitude glacial system. This climate regime caused short but pronounced drought periods in the Nile catchment, which are linked to Heinrich events and alternate with more humid interstadials. The clay mineral record further implies that feedback mechanisms between vegetation cover and sediment discharge of the Nile are detectable but of minor importance for the sedimentary record in the southeastern Mediterranean Sea during the investigated African humid periods.

  19. Community Intercomparison Suite (CIS) v1.4.0: a tool for intercomparing models and observations

    Science.gov (United States)

    Watson-Parris, Duncan; Schutgens, Nick; Cook, Nicholas; Kipling, Zak; Kershaw, Philip; Gryspeerdt, Edward; Lawrence, Bryan; Stier, Philip

    2016-09-01

    The Community Intercomparison Suite (CIS) is an easy-to-use command-line tool which has been developed to allow the straightforward intercomparison of remote sensing, in situ and model data. While there are a number of tools available for working with climate model data, the large diversity of sources (and formats) of remote sensing and in situ measurements necessitated a novel software solution. Developed by a professional software company, CIS supports a large number of gridded and ungridded data sources "out-of-the-box", including climate model output in NetCDF or the UK Met Office pp file format, CloudSat, CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization), MODIS (MODerate resolution Imaging Spectroradiometer), Cloud and Aerosol CCI (Climate Change Initiative) level 2 satellite data and a number of in situ aircraft and ground station data sets. The open-source architecture also supports user-defined plugins to allow many other sources to be easily added. Many of the key operations required when comparing heterogenous data sets are provided by CIS, including subsetting, aggregating, collocating and plotting the data. Output data are written to CF-compliant NetCDF files to ensure interoperability with other tools and systems. The latest documentation, including a user manual and installation instructions, can be found on our website (http://cistools.net). Here, we describe the need which this tool fulfils, followed by descriptions of its main functionality (as at version 1.4.0) and plugin architecture which make it unique in the field.

  20. Constraint on the penultimate glacial maximum Northern Hemisphere ice topography (≈140 kyrs BP)

    Science.gov (United States)

    Colleoni, Florence; Wekerle, Claudia; Näslund, Jens-Ove; Brandefelt, Jenny; Masina, Simona

    2016-04-01

    The penultimate glacial maximum (PGM, ≈140 kyrs BP), is known to be the most extensive glaciation on record that occurred during the last 400 kyrs over Eurasia. We used a coupled Atmosphere-Ocean-Sea-Ice-Land model to simulate the climate of the PGM accounting for a reconstruction of the large PGM Eurasian ice sheet. Due to uncertainties in the PGM Laurentide ice-sheet topography, two simulations with different ice-sheet topographies over North America (large as for the Last Glacial Maximum, LGM and small as for 13 kyrs BP) are performed. Results show that the simulated PGM glacial maximum climates are of comparable magnitude with previous simulations of the LGM in both cases. Assuming a small Laurentide ice-sheet instead of the LGM one in our PGM simulations results in a shift in the planetary waves. This causes an increase in storm track activity over the North Atlantic as well as higher temperatures and precipitation rates over North America, North Atlantic and over the Eurasian ice sheet. In addition, it induces a negative temperature anomaly over East Siberia yielding a thick snow cover, which seems to be in agreement with data from recent Arctic campaigns suggesting that an ice cap developed over Beringia during the PGM. All together, the changes in large-scale circulation and regional climate simulated using a small Laurentide ice sheet match the proxies well. Based on our findings, we suggest that the Laurentide ice sheet might have been smaller during the PGM than during the LGM, in turn also implying a larger Eurasian ice sheet than during the LGM, which is supported by various geological evidence of the PGM.

  1. In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small cell lung cancer.

    Science.gov (United States)

    Fahham, Duha; Weiss, Ido D; Abraham, Michal; Beider, Katia; Hanna, Wald; Shlomai, Zippora; Eizenberg, Orly; Zamir, Gideon; Izhar, Uzi; Shapira, Oz M; Peled, Amnon; Wald, Ori

    2012-11-01

    CXCR4/CXCL12 interactions promote non-small cell lung cancer (NSCLC) growth and dissemination. Furthermore, this axis might promote NSCLC resistance to chemotherapy and/or radiotherapy. Therefore, the CXCR4/CXCL12 axis constitutes an attractive therapeutic target for the treatment of NSCLC. We aimed to characterize the therapeutic efficacy of the novel CXCR4 antagonist BKT140 against human NSCLC. We determined the CXCR4 expression in 5 NSCLC cell lines (H358, A549, H460, H1299, and L4). We then tested the colony-forming capacity and proliferation of these cells in the presence of CXCL12 and BKT140. Next, we measured the in vivo growth of A549 and H460 xenografts with or without BKT140 treatment. Finally, we examined, in vitro, the potential antiproliferative effect of BKT140 combined with cisplatin or paclitaxel and after irradiation of NSCLC cells. All tested cell lines expressed CXCR4 and showed increased colony formation in response to CXCL12 stimulation. BKT140 reduced the colony-forming capacity of NSCLC cells. Proliferation assays demonstrated both cytotoxic and cytostatic properties for this peptide. H460 cells were the most sensitive to BKT140 and A549 cells the least. Subcutaneous administration of BKT140 significantly delayed the development of H460 xenografts and showed a similar trend for A549 xenografts. Finally, the antiproliferative effects of BKT140 appears to be additive to those of chemotherapeutic drugs and radiotherapy. Targeting the CXCL12/CXCR4 axis with BKT140 attenuated NSCLC cells tumor growth and augmented the effects of chemotherapy and radiotherapy. Future research will benefit from delineating the downstream mechanism of BKT140 action and defining BKT140 susceptibility markers. Crown Copyright © 2012. Published by Mosby, Inc. All rights reserved.

  2. Computer algorithms for three-dimensional measurement of humeral anatomy: analysis of 140 paired humeri.

    Science.gov (United States)

    Vlachopoulos, Lazaros; Dünner, Celestine; Gass, Tobias; Graf, Matthias; Goksel, Orcun; Gerber, Christian; Székely, Gábor; Fürnstahl, Philipp

    2016-02-01

    In the presence of severe osteoarthritis, osteonecrosis, or proximal humeral fracture, the contralateral humerus may serve as a template for the 3-dimensional (3D) preoperative planning of reconstructive surgery. The purpose of this study was to develop algorithms for performing 3D measurements of the humeral anatomy and further to assess side-to-side (bilateral) differences in humeral head retrotorsion, humeral head inclination, humeral length, and humeral head radius and height. The 3D models of 140 paired humeri (70 cadavers) were extracted from computed tomographic data. Geometric characteristics quantifying the humeral anatomy in 3D were determined in a semiautomatic fashion using the developed computer algorithms. The results between the sides were compared for evaluating bilateral differences. The mean bilateral difference of the humeral retrotorsion angle was 6.7° (standard deviation [SD], 5.7°; range, -15.1° to 24.0°; P = .063); the mean side difference of the humeral head inclination angle was 2.3° (SD, 1.8°; range, -5.1° to 8.4°; P = .12). The side difference in humeral length (mean, 2.9 mm; SD, 2.5 mm; range, -8.7 mm to 10.1 mm; P = .04) was significant. The mean side difference in the head sphere radius was 0.5 mm (SD, 0.6 mm; range, -3.2 mm to 2.2 mm; P = .76), and the mean side difference in humeral head height was 0.8 mm (SD, 0.6 mm; range, -2.4 mm to 2.4 mm; P = .44). The contralateral anatomy may serve as a reliable reconstruction template for humeral length, humeral head radius, and humeral head height if it is analyzed with 3D algorithms. In contrast, determining humeral head retrotorsion and humeral head inclination from the contralateral anatomy may be more prone to error. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  3. Bloodstream Amyloid-beta (1-40) Peptide, Cognition, and Outcomes in Heart Failure.

    Science.gov (United States)

    Bayes-Genis, Antoni; Barallat, Jaume; de Antonio, Marta; Domingo, Mar; Zamora, Elisabet; Vila, Joan; Subirana, Isaac; Gastelurrutia, Paloma; Pastor, M Cruz; Januzzi, James L; Lupón, Josep

    2017-03-06

    In the brain, amyloid-beta generation participates in the pathophysiology of cognitive disorders; in the bloodstream, the role of amyloid-beta is uncertain but may be linked to sterile inflammation and senescence. We explored the relationship between blood levels of amyloid-beta 1-40 peptide (Aβ40), cognition, and mortality (all-cause, cardiovascular, and heart failure [HF]-related) in ambulatory patients with HF. Bloodstream Aβ40 was measured in 939 consecutive patients with HF. Cognition was evaluated with the Pfeiffer questionnaire (adjusted for educational level) at baseline and during follow-up. Multivariate Cox regression analyses and measurements of performance (discrimination, calibration, and reclassification) were used, with competing risk for specific causes of death. Over 5.1 ± 2.9 years, 471 patients died (all-cause): 250 from cardiovascular causes and 131 HF-related. The median Aβ40 concentration was 519.1 pg/mL [Q1-Q3: 361.8-749.9 pg/mL]. The Aβ40 concentration correlated with age, body mass index, renal dysfunction, and New York Heart Association functional class (all P < .001). There were no differences in Aβ40 in patients with and without cognitive impairment at baseline (P = .97) or during follow-up (P = .20). In multivariable analysis, including relevant clinical predictors and N-terminal pro-B-type natriuretic peptide, Aβ40 remained significantly associated with all-cause death (HR, 1.22; 95%CI, 1.10-1.35; P < .001) and cardiovascular death (HR, 1.18; 95%CI, 1.03-1.36; P = .02), but not with HF-related death (HR, 1.13; 95%CI, 0.93-1.37; P = .22). Circulating Aβ40 improved calibration and patient reclassification. Blood levels of Aβ40 are not associated with cognitive decline in HF. Circulating Aβ40 was predictive of mortality and may indicate systemic aging. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  4. Cerebrospinal Fluid A beta(1-40) Improves Differential Dementia Diagnosis in Patients with Intermediate P-tau(181P) Levels

    NARCIS (Netherlands)

    Slaets, Sylvie; Le Bastard, Nathalie; Martin, Jean-Jacques; Sleegers, Kristel; Van Broeckhoven, Christine; De Deyn, Peter Paul; Engelborghs, Sebastiaan

    2013-01-01

    It is assumed that the concentration of amyloid-beta(1-40) (A beta(1-40)) in cerebrospinal fluid (CSF) reflects the total amount of A beta protein in the brain and thus allows a better interpretation of inter-individual differences in A beta quantity than the A beta(1-42) concentration. In this stud

  5. 25 CFR 140.5 - Bureau of Indian Affairs employees not to contract or trade with Indians except in certain cases.

    Science.gov (United States)

    2010-04-01

    ... have not exercised any undue influence nor used any special knowledge received by reason of my... trade with Indians except in certain cases. 140.5 Section 140.5 Indians BUREAU OF INDIAN AFFAIRS... employees not to contract or trade with Indians except in certain cases. (a) Definitions of terms as used in...

  6. 15 CFR 801.12 - Rules and regulations for the BE-140, Benchmark Survey of Insurance Transactions by U.S...

    Science.gov (United States)

    2010-01-01

    ..., Benchmark Survey of Insurance Transactions by U.S. Insurance Companies with Foreign Persons. 801.12 Section.... AND FOREIGN PERSONS § 801.12 Rules and regulations for the BE-140, Benchmark Survey of Insurance Transactions by U.S. Insurance Companies with Foreign Persons. (a) The BE-140, Benchmark Survey of...

  7. 8 CFR 245.18 - How can physicians (with approved Forms I-140) that are serving in medically underserved areas or...

    Science.gov (United States)

    2010-01-01

    ... when the Service approves a Form I-140 petition with a national interest job offer waiver, the... the Form I-140 and of the national interest waiver. (j) Will a Service officer interview the physician... adjustment interview with a Service officer, unless the Service waives the interview as provided in §...

  8. Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection.

    Science.gov (United States)

    Olszko, M E; Adair, J E; Linde, I; Rae, D T; Trobridge, P; Hocum, J D; Rawlings, D J; Kiem, H-P; Trobridge, G D

    2015-07-01

    Foamy virus (FV) vectors are promising for hematopoietic stem cell (HSC) gene therapy but preclinical data on the clonal composition of FV vector-transduced human repopulating cells is needed. Human CD34(+) human cord blood cells were transduced with an FV vector encoding a methylguanine methyltransferase (MGMT)P140K transgene, transplanted into immunodeficient NOD/SCID IL2Rγ(null) mice, and selected in vivo for gene-modified cells. The retroviral insertion site profile of repopulating clones was examined using modified genomic sequencing PCR. We observed polyclonal repopulation with no evidence of clonal dominance even with the use of a strong internal spleen focus forming virus promoter known to be genotoxic. Our data supports the use of FV vectors with MGMTP140K for HSC gene therapy but also suggests additional safety features should be developed and evaluated.

  9. Primary thermometry from 2.5 K to 140 K applying dielectric-constant gas thermometry

    Science.gov (United States)

    Gaiser, Christof; Fellmuth, Bernd; Haft, Norbert

    2017-02-01

    Recent thermodynamic temperature measurements at PTB with dielectric-constant gas thermometry were performed up to 140 K. Particular care was taken to check for possible systematic sources of errors by repeating experiments applying two new measuring capacitors and both helium and neon as working gases. The development of a new method for determining the effective compressibility of the new capacitors as a function of temperature has decreased the uncertainty significantly. The combination of the recently obtained results with former values of thermodynamic temperature, corrected using new thermodynamic input data, has yielded a consistent dataset in the range from 2.5 K to 38 K as well as at 84 K, 120 K, 130 K, and 140 K. This dataset is in good agreement with the newest results of acoustic gas thermometry, which has quite different sources of uncertainty compared with dielectric-constant gas thermometry.

  10. Numerical study of Pavlovskiy coal pulverized combustion in the furnace of BKZ-210-140 steam boiler

    Science.gov (United States)

    Zavorin, A. S.; Gil, A. V.; Khaustov, P. S.; Tabakaev, R. B.; Buslov, D. A.

    2014-10-01

    In this paper pulverized combustion of insufficiently investigated low-grade Pavlovskiy coal is simulated using the modern engineering software FIRE 3D. The object of study is a widespread in Russia BKZ-210-140 steam boiler. The results of computer simulation are represented with average temperatures in horizontal sections and oxygen concentration. Curves are plotted for three steam generating capacity loads of the boiler: 100%, 70% and 50%.

  11. Search for supersymmetric particles at 130 GeV < √s < 140 GeV at LEP

    Science.gov (United States)

    Acciarri, M.; Adam, A.; Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.; Alpat, B.; Alcaraz, J.; Alemanni, G.; Allaby, J.; Aloisio, A.; Alverson, G.; Alviggi, M. G.; Ambrosi, G.; Anderhub, H.; Andreev, V. P.; Angelescu, T.; Antreasyan, D.; Arefiev, A.; Azemoon, T.; Aziz, T.; Bagnaia, P.; Baksay, L.; Ball, R. C.; Banerjee, S.; Banicz, K.; Barillère, R.; Barone, L.; Bartalini, P.; Baschirotto, A.; Basile, M.; Battiston, R.; Bay, A.; Becattini, F.; Becker, U.; Behner, F.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B. L.; Biasini, M.; Biland, A.; Bilei, G. M.; Blaising, J. J.; Blyth, S. C.; Bobbink, G. J.; Bock, R.; Böhm, A.; Borgia, B.; Boucham, A.; Bourilkov, D.; Bourquin, M.; Brambilla, E.; Branson, J. G.; Brigljevic, V.; Brock, I. C.; Buijs, A.; Bujak, A.; Burger, J. D.; Burger, W. J.; Busenitz, J.; Buytenhuijs, A.; Cai, X. D.; Campanelli, M.; Capell, M.; Romeo, G. Cara; Caria, M.; Carlino, G.; Cartacci, A. M.; Casaus, J.; Castellini, G.; Castello, R.; Cavallari, F.; Cavallo, N.; Cecchi, C.; Cerrada, M.; Cesaroni, F.; Chamizo, M.; Chan, A.; Chang, Y. H.; Chaturvedi, U. K.; Chemarin, M.; Chen, A.; Chen, C.; Chen, G.; Chen, G. M.; Chen, H. F.; Chen, H. S.; Chereau, X.; Chiefari, G.; Chien, C. Y.; Choi, M. T.; Cifarelli, L.; Cindolo, F.; Civinini, C.; Clare, I.; Clare, R.; Cohn, H. O.; Coignet, G.; Colijn, A. P.; Colino, N.; Commichau, V.; Costantini, S.; Cotorobai, F.; de la Cruz, B.; Dai, T. S.; D'Alessandro, R.; de Asmundis, R.; De Boeck, H.; Degré, A.; Deiters, K.; Denes, P.; DeNotaristefani, F.; DiBitonto, D.; Diemoz, M.; van Dierendonck, D.; Di Lodovico, F.; Dionisi, C.; Dittmar, M.; Dominguez, A.; Doria, A.; Dorne, I.; Dova, M. T.; Drago, E.; Duchesneau, D.; Duinker, P.; Duran, I.; Dutta, S.; Easo, S.; Efremenko, Yu; El Mamouni, H.; Engler, A.; Eppling, F. J.; Erné, F. C.; Ernenwein, J. P.; Extermann, P.; Fabre, M.; Faccini, R.; Falciano, S.; Favara, A.; Fay, J.; Felcini, M.; Ferguson, T.; Fernandez, D.; Ferroni, F.; Fesefeldt, H.; Fiandrini, E.; Field, J. H.; Filthaut, F.; Fisher, P. H.; Forconi, G.; Fredj, L.; Freudenreich, K.; Galaktionov, Yu; Ganguli, S. N.; Gau, S. S.; Gentile, S.; Gerald, J.; Gheordanescu, N.; Giagu, S.; Goldfarb, S.; Goldstein, J.; Gong, Z. F.; Gougas, A.; Gratta, G.; Gruenewald, M. W.; Gupta, V. K.; Gurtu, A.; Gutay, L. J.; Hangarter, K.; Hartmann, B.; Hasan, A.; He, J. T.; Hebbeker, T.; Hervé, A.; van Hoek, W. C.; Hofer, H.; Hoorani, H.; Hou, S. R.; Hu, G.; Ilyas, M. M.; Innocente, V.; Janssen, H.; Jin, B. N.; Jones, L. W.; de Jong, P.; Josa-Mutuberria, I.; Kasser, A.; Khan, R. A.; Kamyshkov, Yu; Kapinos, P.; Kapustinsky, J. S.; Karyotakis, Y.; Kaur, M.; Kienzle-Focacci, M. N.; Kim, D.; Kim, J. K.; Kim, S. C.; Kim, Y. G.; Kinnison, W. W.; Kirkby, A.; Kirkby, D.; Kirkby, J.; Kittel, W.; Klimentov, A.; König, A. C.; Köngeter, A.; Korolko, I.; Koutsenko, V.; Koulbardis, A.; Kraemer, R. W.; Kramer, T.; Krenz, W.; Kuijten, H.; Kunin, A.; de Guevara, P. Ladron; Landi, G.; Lapoint, C.; Lassila-Perini, K.; Lebeau, M.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, J. S.; Lee, K. Y.; Le Goff, J. M.; Leiste, R.; Lenti, M.; Leonardi, E.; Levtchenko, P.; Li, C.; Lieb, E.; Lin, W. T.; Linde, F. L.; Lindemann, B.; Lista, L.; Liu, Z. A.; Lohmann, W.; Longo, E.; Lu, W.; Lu, Y. S.; Lübelsmeyer, K.; Luci, C.; Luckey, D.; Ludovici, L.; Luminari, L.; Lustermann, W.; Ma, W. G.; Macchiolo, A.; Maity, M.; Majumder, G.; Malgeri, L.; Malinin, A.; Maña, C.; Mangla, S.; Marchesini, P.; Marin, A.; Martin, J. P.; Marzano, F.; Massaro, G. G. G.; Mazumdar, K.; McNally, D.; McNeil, R. R.; Mele, S.; Merola, L.; Meschini, M.; Metzger, W. J.; von der Mey, M.; Mi, Y.; Mihul, A.; van Mil, A. J. W.; Mirabelli, G.; Mnich, J.; Möller, M.; Monteleoni, B.; Moore, R.; Morganti, S.; Mount, R.; Müller, S.; Muheim, F.; Nagy, E.; Nahn, S.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Nippe, A.; Nowak, H.; Organtini, G.; Ostonen, R.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Park, H. K.; Pascale, G.; Passaleva, G.; Patricelli, S.; Paul, T.; Pauluzzi, M.; Paus, C.; Pauss, F.; Peach, D.; Pei, Y. J.; Pensotti, S.; Perret-Gallix, D.; Petrak, S.; Pevsner, A.; Piccolo, D.; Pieri, M.; Pinto, J. C.; Piroué, P. A.; Pistolesi, E.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Produit, N.; Raghavan, R.; Rahal-Callot, G.; Rancoita, P. G.; Rattaggi, M.; Raven, G.; Razis, P.; Read, K.; Redaelli, M.; Ren, D.; Rescigno, M.; Reucroft, S.; Ricker, A.; Riemann, S.; Riemers, B. C.; Riles, K.; Ro, S.; Robohm, A.; Rodin, J.; Rodriguez, F. J.; Roe, B. P.; Röhner, S.; Romero, L.; Rosier-Lees, S.; Rosselet, Ph; van Rossum, W.; Roth, S.; Rubio, J. A.; Rykaczewski, H.; Salicio, J.; Sanchez, E.; Santocchia, A.; Sarakinos, M. E.; Sarkar, S.; Sassowsky, M.; Schäfer, C.; Schegelsky, V.; Schmidt-Kaerst, S.; Schmitz, D.; Schmitz, P.; Schneegans, M.; Schoeneich, B.; Scholz, N.; Schopper, H.; Schotanus, D. J.; Schulte, R.; Schultze, K.; Schwenke, J.; Schwering, G.; Sciacca, C.; Sciarrino, D.; Sens, J. C.; Servoli, L.; Shevchenko, S.; Shivarov, N.; Shoutko, V.; Shukla, J.; Shumilov, E.; Siedenburg, T.; Son, D.; Sopczak, A.; Smith, B.; Spillantini, P.; Steuer, M.; Stickland, D. P.; Sticozzi, F.; Stone, H.; Stoyanov, B.; Straessner, A.; Strauch, K.; Sudhakar, K.; Sultanov, G.; Sun, L. Z.; Susinno, G. F.; Suter, H.; Swain, J. D.; Tang, X. W.; Tauscher, L.; Taylor, L.; Ting, Samuel C. C.; Ting, S. M.; Toker, O.; Tonisch, F.; Tonutti, M.; Tonwar, S. C.; Tóth, J.; Tsaregorodtsev, A.; Tully, C.; Tuchscherer, H.; Tung, K. L.; Ulbricht, J.; Uwer, U.; Valente, E.; Van de Walle, R. T.; Vetlitsky, I.; Viertel, G.; Vivargent, M.; Völkert, R.; Vogel, H.; Vogt, H.; Vorobiev, I.; Vorobyov, A. A.; Vorobyov, An. A.; Vorvolakos, A.; Wadhwa, M.; Wallraff, W.; Wang, J. C.; Wang, X. L.; Wang, Y. F.; Wang, Z. M.; Weber, A.; Wittgenstein, F.; Wu, S. X.; Wynhoff, S.; Xu, J.; Xu, Z. Z.; Yang, B. Z.; Yang, C. G.; Yao, X. Y.; Ye, J. B.; Yeh, S. C.; You, J. M.; Zaccardelli, C.; Zalite, An; Zemp, P.; Zeng, J. Y.; Zeng, Y.; Zhang, Z.; Zhang, Z. P.; Zhou, B.; Zhou, G. J.; Zhou, Y.; Zhu, G. Y.; Zhu, R. Y.; Zichichi, A.; L3 Collaboration

    1996-02-01

    A search for supersymmetric particles (charginos, neutralinos, sleptons and stop quarks) has been performed with data collected by the L3 detector during the November 1995 run of the LEP collider at centre of mass energies between 130 and 140 GeV with a total integrated luminosity of 5.1 pb -1. We observe no signal for supersymmetric particles and we set improved exclusion limits on their production cross sections and masses.

  12. Mutagenesis of tGCN5 core region reveals two critical surface residues F90 and R140

    Energy Technology Data Exchange (ETDEWEB)

    Mehta, Kinjal Rajesh; Chan, Yan M.; Lee, Man X.; Yang, Ching Yao; Voloshchuk, Natalya [Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, 6 MetroTech Center, Brooklyn, NY 11201 (United States); Montclare, Jin Kim, E-mail: jmontcla@poly.edu [Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, 6 MetroTech Center, Brooklyn, NY 11201 (United States); Department of Biochemistry, SUNY-Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203 (United States)

    2010-09-24

    Research highlights: {yields} Mutagenesis of the tGCN5 core region reveals two residues important for function. {yields} Developed a fluorescent lysate-based activity assay to assess mutants. {yields} Surface-exposed residues F90 and R140 of tGCN5 are critical for H3 acetylation. -- Abstract: Tetrahymena General Control Non-Derepressor 5 (tGCN5) is a critical regulator of gene transcription via acetylation of histones. Since the acetylation ability has been attributed to the 'core region', we perform mutagenesis of residues within the tGCN5 'core region' in order to identify those critical for function and stability. Residues that do not participate in catalysis are identified, mutated and characterized for activity, structure and thermodynamic stability. Variants I107V, Q114L, A121T and A130S maintain the acetylation function relative to wild-type tGCN5, while variants F90Y, F112R and R140H completely abolish function. Of the three non-functional variants, since F112 is mutated into a non-homologous charged residue, a loss in function is expected. However, the remaining two variants are mutated into homologous residues, suggesting that F90 and R140 are critical for the activity of tGCN5. While mutation to homologous residue maintains acetylation of histone H3 for the majority of the variants, the two surface-exposed residues, F90 and R140, appear to be essential for tGCN5 function, structure or stability.

  13. Blood-Letting Puncture and Cupping Therapies Combined with Acupuncture for Treatment of 140 Cases of Fibrositis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hong-liang; DUAN Shu-min

    2009-01-01

    @@ Fibrositis, also known as myofibrositis in nape and back, often occurs all the year round, especially between spring and summer or summer and autumn. Pathogenic cold and fatigue can induce aseptic inflammation in nape and back with pain, limited movement and other symptoms. The author used blood-letting puncture and cupping plus acupuncture to treat 140 cases of fibrositis from February 2003 to December 2006 with satisfactory therapeutic effect. A report is as follows.

  14. Study of the decay K+ => pi+,nu,nubar in the momentum region 140

    CERN Document Server

    Artamonov, A V; Bhuyan, B; Blackmore, E W; Bryman, D A; Chen, S; Chiang, I-H; Christidi, I -A; Cooper, P S; Diwan, M V; Frank, J S; Fujiwara, T; Hu, J; Ives, J; Jaffe, D E; Kabe, S; Kettell, S H; Khabibullin, M M; Khotjantsev, A N; Kitching, P; Kobayashi, M; Komatsubara, T K; Konaka, A; Kozhevnikov, A P; Kudenko, Yu G; Kushnirenko, A; Landsberg, L G; Lewis, B; Li, K K; Littenberg, L S; MacDonald, J A; Mildenberger, J; Mineev, O V; Miyajima, M; Mizouchi, K; Mukhin, V A; Muramatsu, N; Nakano, T; Nomachi, M; Nomura, T; Numao, T; Obraztsov, V F; Omata, K; Patalakha, D I; Petrenko, S V; Poutissou, R; Ramberg, E J; Redlinger, G; Sato, T; Sekiguchi, T; Shinkawa, T; Strand, R C; Sugimoto, S; Tamagawa, Y; Tschirhart, R; Tsunemi, T; Vavilov, D V; Viren, B; Wang, Zhe; Yershov, N V; Yoshimura, Y; Yoshioka, T

    2009-01-01

    Experiment E949 at Brookhaven National Laboratory has observed three new events consistent with the decay K+ => pi+,nu,nubar in the pion momentum region 140 pi+,nu,nubar events to seven. Combining this observation with previous results, assuming the pion spectrum predicted by the standard model, results in a branching ratio of (1.73+1.15-1.05)e-10. An interpretation of the results for alternative models of the decay K^ => pi+,nothing is also presented.

  15. Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults▿

    Science.gov (United States)

    Jacobson, Jeffrey M.; Lalezari, Jacob P.; Thompson, Melanie A.; Fichtenbaum, Carl J.; Saag, Michael S.; Zingman, Barry S.; D'Ambrosio, Paul; Stambler, Nancy; Rotshteyn, Yakov; Marozsan, Andre J.; Maddon, Paul J.; Morris, Stephen A.; Olson, William C.

    2010-01-01

    The anti-CCR5 antibody PRO 140 has shown potent and prolonged antiretroviral activity in subjects infected with CCR5-tropic (R5) HIV-1. Prior studies have examined single intravenous doses ranging up to 5 mg/kg of body weight or up to three subcutaneous doses ranging up to 324 mg. Here we report the results of a randomized, double-blind, placebo-controlled trial that examined the antiviral activity, tolerability, and pharmacokinetics of single 5-mg/kg and 10-mg/kg intravenous infusions of PRO 140 in 31 treated subjects. Eligibility criteria included HIV-1 RNA levels of >5,000 copies/ml, CD4+ cell counts of >300/μl, no antiretroviral therapy for ≥12 weeks, and detection of only R5 HIV-1 in the original Trofile assay. Following poststudy testing with an enhanced-sensitivity Trofile assay, one subject treated with 10 mg/kg was reclassified as having dual/mixed-tropic virus at screening, and the data for that subject were censored from efficacy analyses. The mean maximum reduction of the HIV-1 RNA level from the baseline level was 1.8 log10 units for both the 5-mg/kg and 10-mg/kg doses (P PRO 140 dose groups. Treatment was generally well tolerated, with no dose-limiting toxicity being observed. Peak serum concentrations and overall exposures increased proportionally with dose. In summary, single 5-mg/kg and 10-mg/kg doses of PRO 140 exhibited potent, long-lived antiviral activity and were generally well tolerated. The findings further delineate the safety and antiviral properties of this novel, long-acting antiretroviral agent. PMID:20660677

  16. TAGS measurements of 100Nb ground and isomeric states and 140Cs for neutrino physics with the new DTAS detector

    Directory of Open Access Journals (Sweden)

    Guadilla V.

    2017-01-01

    Full Text Available In this work we report on total absorption γ-ray spectroscopy measurements of the β decay of fission products that are important contributors to the antineutrino spectrum. The experiment was performed at IGISOL as a part of a campaign of measurements with the new DTAS spectrometer. Preliminary results of the analysis of the β decay of 100Nb,100mNb and 140Cs are presented.

  17. Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice.

    Directory of Open Access Journals (Sweden)

    Viviana Buffa

    Full Text Available In the present study we investigate the impact of a range of TLR ligands and chitosan as potential adjuvants for different routes of mucosal immunisation (sublingual (SL, intranasal (IN, intravaginal (IVag and a parenteral route (subcutaneous (SC in the murine model. We assess their ability to enhance antibody responses to HIV-1 CN54gp140 (gp140 and Tetanus toxoid (TT in systemic and vaginal compartments. A number of trends were observed by route of administration. For non-adjuvanted antigen, SC>SL>IN immunisation with respect to systemic IgG responses, where endpoint titres were greater for TT than for gp140. In general, co-administration with adjuvants increased specific IgG responses where IN = SC>SL, while in the vaginal compartment IN>SL>SC for specific IgA. In contrast, for systemic and mucosal IgA responses to antigen alone SL>IN = SC. A number of adjuvants increased specific systemic IgA responses where in general IN>SL>SC immunisation, while for mucosal responses IN = SL>SC. In contrast, direct intravaginal immunisation failed to induce any detectable systemic or mucosal responses to gp140 even in the presence of adjuvant. However, significant systemic IgG responses to TT were induced by intravaginal immunisation with or without adjuvant, and detectable mucosal responses IgG and IgA were observed when TT was administered with FSL-1 or Poly I∶C. Interestingly some TLRs displayed differential activity dependent upon the route of administration. MPLA (TLR4 suppressed systemic responses to SL immunisation while enhancing responses to IN or SC immunisation. CpG B enhanced SL and IN responses, while having little or no impact on SC immunisation. These data demonstrate important route, antigen and adjuvant effects that need to be considered in the design of mucosal vaccine strategies.

  18. Magnetic hyperfine field in Tb Zn compound measured by PAC spectroscopy using {sup 111}Cd and {sup 140}Ce

    Energy Technology Data Exchange (ETDEWEB)

    Bosch-Santos, B.; Cabrera-Pasca, G.A.; Carbonari, A.W.; Costa, M.S.; Saxena, R.N., E-mail: brianna@usp.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The ferromagnetic compound Tb Zn has been investigated by perturbed {gamma}-{gamma} angular correlation (PAC) spectroscopy using {sup 111}In{yields}{sup 111}Cd (t{sub 1/2} = 85 ns) and {sup 140}La{yields}{sup 140}Ce (t{sub 1/2} = 3,4 ns) as probe nuclei. Measurements were carried out in the temperature range of 10 - 295K for the {sup 111}Cd probe and below Curie temperature (T{sub C}) for the {sup 140}Ce probe. The study of magnetic properties of rare earth (R) and zinc compounds of the type RZn is interesting because Zn ion is a closed shell atom and the rare earth elements present a localized magnetism associated with 4f electrons, which do not participate in chemical bonds. Therefore, the magnetic properties of these compounds are only originated from the 4f electrons of rare earth. Furthermore, the compounds exhibit the highly symmetric cubic structure of the CsCl prototype and have a Curie temperature of TbZn is T{sub C} {approx} 204 K. (author)

  19. Effects of tanshinone on neuropathological changes induced by amyloid β-peptide1-40 injection in rat hippocampus

    Institute of Scientific and Technical Information of China (English)

    Long-xuan LI; Jia-pei DAI; Li-qiang RU; Guang-fu YIN; Bin ZHAO

    2004-01-01

    AIM: To investigate the effect of tanshinone (Tan) on the neuropathological changes induced by amyloid β-peptide1-40 (Aβ-40) injection in hippocampus in rats. METHODS: Aβ1-40 10 μg was injected bilaterally into the dorsal blade of the dentate gyrus in the hippocampus. The level of acetylcholinesterase (AChE) in hippocampus was evaluated by histochemistry. The expressions of neuronal nitric oxide synthase (nNOS) and inducible form of NOS (iNOS) were detected by immunohistochemistry and Western blot. Aβ-40-injected rats were treated ig with Tan, the major active ingredient from Salvia miltiorrhiza of Chinese herb extract. RESULTS: The level of AChE positive fibers of each subfield in Aβ1-40-injected hippocampus decreased significantly compared with those of control (P<0.01). The expression of nNOS was down-regulated whereas the iNOS was up-regulated. After treatment with Tan (50 mg/kg, ig), the changes mentioned above were significantly improved. Moreover, the correlation analysis revealed a significant negative correlation between the area percentage of AChE positive fibers and the number of iNOS positive neural cells in CA 1, CA2 to CA3 (CA2-3), and dentate gyrus (DG) subfields (P<0.01). CONCLUSION:Tan can protect the neuropathological changes induced by Aβ-40 injection in hippocampus.

  20. Cu(Ⅱ) Potentiation of Alzheimer Aβ1-40 Cytotoxicity and Transition on its Secondary Structure

    Institute of Scientific and Technical Information of China (English)

    Xue-Ling DAI; Ya-Xuan SUN; Zhao-Feng JIANG

    2006-01-01

    Mounting evidence has shown that dyshomeostasis of the redox-active biometals such as Cu and Fe can lead to oxidative stress, which plays a key role in the neuropathology of Alzheimer's disease (AD). Here we demonstrate that with the formation of Cu(Ⅱ)-Aβ1-40 complexes, copper markedly potentiates the neurotoxicity exhibited by β-amyloid peptide (Aβ). A greater amount of hydrogen peroxide was released when Cu(Ⅱ).Aβ1-40 complexes was added to the xanthine oxidase/xanthine system detected by potassium iodide spectrophotometry. Copper bound to Aβ1-40 was observed by electron paramagnetic resonance (EPR) spectroscopy. Circular dichroism (CD) studies indicated that copper chelation could cause a structural transition of Aβ. The addition of copper to Aβ introduced an increase on β-sheet as well as α-helix, which may be responsible for the aggregation of Aβ. We hypothesized that Aβ aggregation induced by copper may be responsible for local injury in AD. The interaction between Cu2+ and Aβ also provides a possible mechanism for the enrichment of metal ions in amyloid plaques in the AD brain.

  1. Nitration of Y10 in Aβ1-40: is it a compensatory reaction against oxidative/nitrative stress and Aβ aggregation?

    Science.gov (United States)

    Zhao, Jie; Wang, Peipei; Li, Hailing; Gao, Zhonghong

    2015-03-16

    Amyloid β peptide (Aβ) aggregation is considered to be a crucial pathological biomarker of Alzheimer's disease (AD). It was found that Aβ and heme can form an Aβ-heme complex, which results in increased heme pseudoperoxidase activity. Recently, we found that increasing pseudoperoxidase activity induces elevated tyrosine nitration on Aβ in the presence of nitrite and hydrogen peroxide. However, the nature of tyrosine nitration of Aβ and its physiologic significance are still unknown. In this study, we revealed that Aβ1-40 can be nitrated in vitro by binding to heme in the presence of nitrite and hydrogen peroxide. Moreover, we found that tyrosine nitration had little effect on Aβ1-40's binding activity with heme. A TMB assay also revealed that the peroxidase activity of the heme-Aβ1-40Y10(3N)T (tyrosine 10 was replaced with 3-nitrtotyrosine in Aβ1-40) complex was moderately increased compared with that of the heme-Aβ1-40 complex. Furthermore, Thioflavin T fluorescence and transmission electron microscopic characterization indicated that tyrosine nitration significantly decreased the aggregation of Aβ1-40. In addition, a cytotoxicity test verified that wild-type Aβ1-40 was more cytotoxic than that of Aβ1-40Y10(3N)T. These results suggest that nitration of Aβ1-40 might be an Aβ detoxicant process and a compensatory reaction to nitrative stress. Our findings may lead to a detailed understanding of the function of Aβ1-40 and may be helpful in preventing and curing AD.

  2. Clinical significance of miR-140-5p and miR-193b expression in patients with breast cancer and relationship to IGFBP5

    Directory of Open Access Journals (Sweden)

    Gökçe Güllü

    2015-03-01

    Full Text Available The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015. Samples with no immunohistochemical staining for IGFBP5 showed increased miR-140-5p expression (p = 0.009. miR-140-5p expression was elevated in invasive ductal carcinomas (p = 0.002, whereas basal-like tumors had decreased expression of miR-140-5p compared to other tumors (p = 0.008. Lymph node-positive samples showed an approximately 13-fold increase in miR-140-5p expression compared to lymph node-negative tissue (p = 0.049. These findings suggest that miR-140-5p, but not miR-193b, could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients. Further studies are needed to clarify the expressional regulation of IGFBP5 by miR-140-5p.

  3. Water and ammonia abundances in S140 with the Odin satellite

    Science.gov (United States)

    Persson, C. M.; Olberg, M.; . Hjalmarson, Å.; Spaans, M.; Black, J. H.; Frisk, U.; Liljeström, T.; Olofsson, A. O. H.; Poelman, D. R.; Sandqvist, Aa.

    2009-02-01

    Aims: We investigate the effect of the physical environment on water and ammonia abundances across the S140 photodissociation region (PDR) with an embedded outflow. Methods: We used the Odin satellite to obtain strip maps of the ground-state rotational transitions of ortho-water and ortho-ammonia, as well as CO(5-4) and 13CO(5-4) across the PDR, and H218O in the central position. A physi-chemical inhomogeneous PDR model was used to compute the temperature and abundance distributions for water, ammonia, and CO. A multi-zone escape probability method then calculated the level populations and intensity distributions. These results are compared to a homogeneous model computed with an enhanced version of the RADEX code. Results: H2O, NH{3}, and 13CO show emission from an extended PDR with a narrow line width of 3 km s-1. Like CO, the water line profile is dominated by outflow emission, but mainly in the red wing. Even though CO shows strong self-absorption, no signs of self-absorption are seen in the water line. The H218O molecule is not detected. The PDR model suggests that the water emission arises mainly from the surfaces of optically thick, high-density clumps with n(H_2) ⪆ 106 cm-3 and a clump water abundance, with respect to H2, of 5 × 10-8. The mean water abundance in the PDR is 5 × 10-9 and between 4 × 10-8-4 × 10-7 in the outflow derived from a simple two-level approximation. The RADEX model points to a somewhat higher average PDR water abundance of 1 × 10-8. At low temperatures deep in the cloud, the water emission is weaker, likely due to adsorption onto dust grains, while ammonia is still abundant. Ammonia is also observed in the extended clumpy PDR, likely from the same high density and warm clumps as water. The average ammonia abundance is about the same as for water: 4 × 10-9 and 8 × 10-9 given by the PDR model and RADEX, respectively. The differences between the models most likely arise from uncertainties in density, beam-filling, and volume

  4. Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.

    Science.gov (United States)

    Nefedova, Victoria V; Datskevich, Petr N; Sudnitsyna, Maria V; Strelkov, Sergei V; Gusev, Nikolai B

    2013-08-01

    Some physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathy were analyzed. Mutation K141Q did not affect intrinsic Trp fluorescence and interaction with hydrophobic probe bis-ANS, whereas mutation R140G decreased both intrinsic fluorescence and fluorescence of bis-ANS bound to HspB1. Both mutations decreased thermal stability of HspB1. Mutation R140G increased, whereas mutation K141Q decreased the rate of trypsinolysis of the central part (residues 5-188) of HspB1. Both the wild type HspB1 and its K141Q mutant formed large oligomers with apparent molecular weight ∼560 kDa. The R140G mutant formed two types of oligomers, i.e. large oligomers tending to aggregate and small oligomers with apparent molecular weight ∼70 kDa. The wild type HspB1 formed mixed homooligomers with R140G mutant with apparent molecular weight ∼610 kDa. The R140G mutant was unable to form high molecular weight heterooligomers with HspB6, whereas the K141Q mutant formed two types of heterooligomers with HspB6. In vitro measured chaperone-like activity of the wild type HspB1 was comparable with that of K141Q mutant and was much higher than that of R140G mutant. Mutations of homologous hot-spot Arg (R140G of HspB1 and R120G of αB-crystallin) induced similar changes in the properties of two small heat shock proteins, whereas mutations of two neighboring residues (R140 and K141) induced different changes in the properties of HspB1.

  5. Experimental results of the 140 GHz, 1 MW long-pulse gyrotron for W7-X

    Science.gov (United States)

    Koppenburg, K.; Arnold, A.; Borie, E.; Dammertz, G.; Giguet, E.; Heidinger, R.; Illy, S.; Kuntze, M.; Le Cloarec, G.; Legrand, F.; Leonhardt, W.; Lievin, C.; Neffe, G.; Piosczyk, B.; Schmid, M.; Thumm, M.

    2003-02-01

    Gyrotrons at high frequency with high output power are mainly developed for microwave heating and current drive in plasmas for thermonuclear fusion. For the stellarator Wendelstein 7-X now under construction at IPP Greifswald, Germany, a 10 MW ECRH system is foreseen. A 1 MW, 140 GHz long-pulse gyrotron has been designed and a pre-prototype (Maquette) has been constructed and tested in an European collaboration between FZK Karlsruhe, CRPP Lausanne, IPF Suttgart, IPP Greifswald, CEA Cadarache and TED Vélizy [1]. The cylindrical cavity is designed for operating in the TE28,8 mode. It is a standard tapered cavity with linear input downtaper and a non-linear uptaper. The diameter of the cylindrical part is 40.96 mm. The transitions between tapers and straight section are smoothly rounded to avoid mode conversion. The TE28,8-cavity mode is transformed to a Gaussian TEM0,0 output mode by a mode converter consisting of a rippled-wall waveguide launcher followed by a three mirror system. The output window uses a single, edge cooled CVD-diamond disk with an outer diameter of 106 mm, a window aperture of 88 mm and a thickness of 1.8 mm corresponding to four half wavelengths. The collector is at ground potential, and a depression voltage for energy recovery can be applied to the cavity and to the first two mirrors. Additional normal-conducting coils are employed to the collector in order to produce an axial magnetic field for sweeping the electron beam with a frequency of 7 Hz. A temperature limited magnetron injection gun without intermediate anode ( diode type ) is used. In short pulse operation at the design current of 40 A an output power of 1 MW could be achieved for an accelerating voltage of 82 kV without depression voltage and with a depression voltage of 25 kV an output power of 1.15 MW at an accelerating voltage of 84 kV has been measured. For these values an efficiency of 49% was obtained. At constant accelerating voltages, the output power did not change up to

  6. Altered emotionality leads to increased pain tolerance in amyloid beta (Abeta1-40) peptide-treated mice.

    Science.gov (United States)

    Pamplona, Fabrício A; Pandolfo, Pablo; Duarte, Filipe S; Takahashi, Reinaldo N; Prediger, Rui D S

    2010-09-01

    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the decline in cognitive functions, but it is also related to emotional disturbances. Since pain experience results from a complex integration of sensory, cognitive and affective processes, it is not surprising that AD patients display a distinct pattern of pain responsivity. We evaluated whether mice treated with amyloid beta (Abeta) peptide-thought to be critical in the pathogenesis of AD-exhibit altered pain responses and its relation to altered emotionality. Mice received a single i.c.v. injection of vehicle (PBS) or Abeta fragment (1-40) (400pmol/mice) and after 30 days, they were evaluated in tests of pain (hotplate, footshock-sensitivity), learning/memory (water-maze), emotionality (elevated plus-maze, forced swim) and locomotion (open-field). Abeta(1-40)-treated mice presented similar latencies to the control group in the hotplate test and similar nociceptive flinch threshold in the footshock-sensitivity test. However, they presented an increased jump threshold in footshock-sensitivity, suggesting increased pain tolerance. Altered emotionality was observed in the elevated plus-maze (EPM) and forced-swim tests (FST), suggesting anxiogenic-like and depressive-like states, respectively. A multifactorial principal component analysis (PCA) revealed that jump threshold of the footshock-sensitivity test falls within 'Emotionality' and 'Pain', showing moderate correlation with each one of the components of behavior. Acute treatment with the antidepressant desipramine (10mg/kg, i.p.) reduced the jump threshold (i.e. pain tolerance) and time of immobility in FST (i.e. depressive-like state). Flinch threshold (i.e. pain sensitivity), locomotion and anxiety were not altered with desipramine treatment. These results suggest that Abeta(1-40) peptide increases pain tolerance, but not pain sensitivity in mice, which seems to be linked to alterations in cognitive/emotional components of pain

  7. Study on the After Cavity Interaction in a 140 GHz Gyrotron Using 3D CFDTD PIC Simulations

    Science.gov (United States)

    Lin, M. C.; Illy, S.; Avramidis, K.; Thumm, M.; Jelonnek, J.

    2016-10-01

    A computational study on after cavity interaction (ACI) in a 140 GHz gryotron for fusion research has been performed using a 3-D conformal finite-difference time-domain (CFDTD) particle-in-cell (PIC) method. The ACI, i.e. beam wave interaction in the non-linear uptaper after the cavity has attracted a lot of attention and been widely investigated in recent years. In a dynamic ACI, a TE mode is excited by the electron beam at the same frequency as in the cavity, and the same mode is also interacting with the spent electron beam at a different frequency in the non-linear uptaper after the cavity while in a static ACI, a mode interacts with the beam both at the cavity and at the uptaper, but at the same frequency. A previous study on the dynamic ACI on a 140 GHz gyrotron has concluded that more advanced numerical simulations such as particle-in-cell (PIC) modeling should be employed to study or confirm the dynamic ACI in addition to using trajectory codes. In this work, we use a 3-D full wave time domain simulation based on the CFDTD PIC method to include the rippled-wall launcher of the quasi-optical output coupler into the simulations which breaks the axial symmetry of the original model employing a symmetric one. A preliminary simulation result has confirmed the dynamic ACI effect in this 140 GHz gyrotron in good agreement with the former study. A realistic launcher will be included in the model for studying the dynamic ACI and compared with the homogenous one.

  8. Evaluation of the performance of a p53 sequencing microarray chip using 140 previously sequenced bladder tumor samples

    DEFF Research Database (Denmark)

    Wikman, Friedrik; Lu, Ming-Lan; Andersen, Thomas Thykjær;

    2000-01-01

    available chip and describes a method to increase the specificity of the chip. Methods: DNA from 140 human bladder tumors was extracted and subjected to a multiplex-PCR before loading onto the p53 GeneChip from Affymetrix. The same samples were previously sequenced by manual dideoxy sequencing. In addition......Background: Testing for mutations of the TP53 gene in tumors is a valuable predictor for disease outcome in certain cancers, but the time and cost of conventional sequencing limit its use. The present study compares traditional sequencing with the much faster microarray sequencing on a commercially...

  9. Study of Relationship Between Neutron Energy and Fission Yields of 95Zr, 140Ba and 147Nd From 235U

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This work measures fission yields of 235U induced by neutrons with energy of thermal, 3.0, 5.0, 5.5, 8.0 and 14.8 MeV. The main purpose is to study the relationship between neutron energy and fission fields of 95Zr,140Ba and 147Nd from 235U by measuring the radioactivity of foil with direct gamma spectrometry. The fission yields induced by fast neutrons are get by fast-thermal-ratio method which based on yields from thermal neutrons, yields by thermal neutron are come from absolute measurement. Since fast-thermal-ratio method eliminates uncertainties of gamma intensity, gamma

  10. In orbit degradation of UV optical components for the wavelength range 10-140 microns. AO 138.3 (FRECOPA)

    Science.gov (United States)

    Delabouinere, J. P.; Carabetian, C.; Hochedez, J. F.

    1992-01-01

    Optical components (thin film filters and multilayered mirrors) for use in the wavelength range 10-140 micro-m were included in the vacuum tight container FRECOPA in preparation for the SOHO mission. They were exposed during 9 months at the beginning of the Long Duration Exposure Facility (LDEF) flight. One batch of components was exposed to the sun, while another one was shielded from solar radiation. The results of the optical transmission measurements of the flight components and of a groundbase reference set, made at the ORSAY Synchotron radiation light source are presented.

  11. In-situ calibration of pulsed eddy current detection of cracks at fasteners in CP-140 aircraft

    Science.gov (United States)

    Underhill, Ross; Stott, Colette; Krause, Thomas W.

    2016-02-01

    The use of the Smallest Half Volume (SHV) robust statistics method and the Mahalanobis distance to blindly distinguish fasteners with cracks from fasteners without is examined. Pulsed eddy current data obtained from CP140 Aurora wing structures is used to test the approach. It is shown that the method can achieve levels of detection very close to those obtained when the same measurement technique is applied with full knowledge of which fasteners have no cracks. The method is applicable to a broad range of similar situations when an objective hit/miss criterion is used.

  12. Convective heat-transfer rate distributions over a 140 deg blunt cone at hypersonic speeds in different gas environments

    Science.gov (United States)

    Stewart, David A.; Chen, Y. K.

    1993-01-01

    Experiments were conducted in air, CO2, and CO2-argon gas mixtures to obtain heating distribution data over a 140 deg blunt cone with various corner radii. The effect of corner radius on the heating distribution over the forebody of the cone was included in the investigation. These experiments provide data for validation of two-dimensional axisymmetric and three-dimensional Navier-Stokes solutions. Heating distribution data and measured bow shock wave stand-off distances for 0 deg angle of attack were compared with predicted values using a two-dimensional axisymmetric Navier-Stokes code.

  13. Multiple Organ Failure in Children with Acute Abdomen:A Report of 140 Cases%小儿急腹症多器官功能衰竭140例临床分析

    Institute of Scientific and Technical Information of China (English)

    金先庆; 林涛

    1988-01-01

    本文报告10年中收治的小儿急腹症多器官功能衰竭(MOF)140例,占同期急腹症总数的2.23%.本组MOF的病死率为49.3%,略高于小儿内科MOF病死率.本文总结小儿急腹症MOF病死率主要与患儿年龄、受累器官数目、是否早期手术以及原发疾病性质等因素有关.循环及呼吸是最常受累的两个系统,也是抢救MOF成败的关键.%From 1977 to 1986,140 childrea with multiple organ failure(MOF)in lacute abdomen were admitted.The total mortality(49.3%)is a little higher than that of MOF in pediatric diseases as reported in Chinese medical literatures.The factors related to the mortality of MOF are:(1)the age of patients,(2)the number of organs or systems involved,(3)the primary disease in abdomen,and (4)the treatment (operation)undertaken.As the circulatory or respiratory failure is the most common cause of death,protection of taese organs would be the key to a sucessful salvage of MOF.

  14. Protocolo quirúrgico en la reconstrucción de la parálisis facial: nuestra experiencia tras 140 casos tratados Protocol in surgical treatment of facial paralysis after 140 treated cases

    Directory of Open Access Journals (Sweden)

    B. Hontanilla Calatayud

    2008-09-01

    Full Text Available El objetivo de este trabajo es presentar nuestro protocolo de actuación en el tratamiento quirúrgico de la parálisis facial tras 140 casos tratados entre los años 2000 y 2007. Este protocolo está basado en los resultados obtenidos con un nuevo sistema de captura del movimiento facial en 3D denominado "Facial Clima", que puede ser considerado como un método objetivo de medición de los resultados en la cirugía de reanimación facial. Así podría compararse en pacientes con parálisis facial, la efectividad de los tratamientos entre distintos centros. Exponemos los resultados obtenidos tanto a nivel de la reconstrucción de la sonrisa como a nivel palpebral.The aim of this study is to present our protocol in the surgical treatment of facial paralysis after 140 treated cases since 2000 to 2007. The protocol is based on the results obtained with a new 3-D capture system of the facial movement called "Facial Clima", that could be considered as the adequate tool to assess the outcome of the facial paralysis reanimation surgery. Thus, patients with facial paralysis could be compared among surgical centres such that effectiveness of facial reanimation operations could be evaluated. The results obtained are exposed for smile and lid reconstruction.

  15. microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN.

    Science.gov (United States)

    Karlsen, Tommy A; Jakobsen, Rune B; Mikkelsen, Tarjei S; Brinchmann, Jan E

    2014-02-01

    Lesions of articular cartilage do not heal spontaneously. One treatment strategy would be to make cartilage in the laboratory by directed chondrogenic differentiation of mesenchymal stem cells (MSCs). To promote our understanding of the molecular control of chondrogenesis, we have compared the changes in microRNAs (miRNAs) during in vitro chondrogenesis of MSCs with those observed in uncultured and dedifferentiated articular chondrocytes (ACs). Several miRNAs showed a reciprocal relationship during the differentiation of MSCs and dedifferentiation of ACs. miR-140-5p and miR-140-3p changed the most during in vitro chondrogenesis, they were the miRNAs most highly expressed in tissue-engineered chondrocytes, and they were also among the miRNAs most highly expressed in uncultured ACs. There was a 57% overlap for the 100 most highly expressed miRNAs in differentiated MSCs and uncultured ACs, but for other miRNAs, the expression pattern was quite different. We transiently and stably inhibited and overexpressed miR-140-5p and miR-140-3p in differentiating MSCs and dedifferentiating ACs, respectively, to describe global effects and identify and validate new targets. Surprisingly, SOX9 and aggrecan proteins were found to be downregulated in anti-miR-140 transduced differentiating MSCs despite unchanged mRNA levels. This suggests that miR-140 stimulates in vitro chondrogenesis by the upregulation of these molecules at the protein level. RALA, a small GTPase, was identified as a miR-140 target and knockdown experiments showed that RALA regulated SOX9 at the protein level. These observations shed new light on the effect of miR-140 for chondrogenesis in vitro and in vivo.

  16. Atorvastatin Prevents Cognitive Deficits Induced by Intracerebroventricular Amyloid-β1-40 Administration in Mice: Involvement of Glutamatergic and Antioxidant Systems.

    Science.gov (United States)

    Martins, Wagner C; dos Santos, Vanessa Valgas; dos Santos, Alessandra Antunes; Vandresen-Filho, Samuel; Dal-Cim, Tharine A; de Oliveira, Karen A; Mendes-de-Aguiar, Claudia B N; Farina, Marcelo; Prediger, Rui Daniel; Viola, Giordano Gubert; Tasca, Carla I

    2015-07-01

    Deposition of amyloid-β (Aβ) peptides into specific encephalic structures has been pointed as an important event related to Alzheimer's disease pathogenesis and associated with activation of glial cells, neuroinflammation, oxidative responses, and cognitive deficits. Aβ-induced pro-oxidative damage may regulate the activity of glutamate transporters, leading to reduced glutamate uptake and, as a consequence, excitotoxic events. Herein, we evaluated the effects of the pretreatment of atorvastatin, a HMG-CoA reductase inhibitor, on behavioral and biochemical alterations induced by a single intracerebroventricular (i.c.v.) injection of aggregated Aβ1-40 in mice. Atorvastatin (10 mg/kg/day, p.o.) was administered through seven consecutive days before Aβ1-40 administration. Aβ1-40 caused significant cognitive impairment in the object-place recognition task (2 weeks after the i.c.v. injection) and this phenomenon was abolished by atorvastatin pretreatment. Ex vivo evaluation of glutamate uptake into hippocampal and cerebral cortices slices showed atorvastatin, and Aβ1-40 decreased hippocampal and cortical Na(+)-dependent glutamate uptake. However, Aβ1-40 increased Na(+)-independent glutamate uptake and it was prevented by atorvastatin in prefrontal cortex slices. Moreover, Aβ1-40 treatment significantly increased the cerebrocortical activities of glutathione reductase and glutathione peroxidase and these events were blunted by atorvastatin pretreatment. Reduced or oxidized glutathione levels were not altered by Aβ1-40 and/or atorvastatin treatment. These results extend the notion of the protective action of atorvastatin against neuronal toxicity induced by Aβ1-40 demonstrating that a pretreatment with atorvastatin prevents the spatial learning and memory deficits induced by Aβ in rodents and promotes changes in glutamatergic and antioxidant systems mainly in prefrontal cortex.

  17. Targeting the CD20 and CXCR4 pathways in non-hodgkin lymphoma with rituximab and high-affinity CXCR4 antagonist BKT140.

    Science.gov (United States)

    Beider, Katia; Ribakovsky, Elena; Abraham, Michal; Wald, Hanna; Weiss, Lola; Rosenberg, Evgenia; Galun, Eithan; Avigdor, Abraham; Eizenberg, Orly; Peled, Amnon; Nagler, Arnon

    2013-07-01

    Chemokine axis CXCR4/CXCL12 is critically involved in the survival and trafficking of normal and malignant B lymphocytes. Here, we investigated the effect of high-affinity CXCR4 antagonist BKT140 on lymphoma cell growth and rituximab-induced cytotoxicity in vitro and in vivo. In vitro efficacy of BKT140 alone or in combination with rituximab was determined in non-Hodgkin lymphoma (NHL) cell lines and primary samples from bone marrow aspirates of patients with NHL. In vivo efficacy was evaluated in xenograft models of localized and disseminated NHL with bone marrow involvement. Antagonizing CXCR4 with BKT140 resulted in significant inhibition of CD20+ lymphoma cell growth and in the induction of cell death, respectively. Combination of BKT140 with rituximab significantly enhanced the apoptosis against the lymphoma cells in a dose-dependent manner. Moreover, rituximab induced CXCR4 expression in lymphoma cell lines and primary lymphoma cells, suggesting the possible interaction between CD20 and CXCR4 pathways in NHL. Primary bone marrow stromal cells (BMSC) further increased CXCR4 expression and protected NHL cells from rituximab-induced apoptosis, whereas BKT140 abrogated this protective effect. Furthermore, BKT140 showed efficient antilymphoma activity in vivo in the xenograft model of disseminated NHL with bone marrow involvement. BKT140 treatment inhibited the local tumor progression and significantly reduced the number of NHL cells in the bone marrow. Combined treatment of BKT140 with rituximab further decreased the number of viable lymphoma cells in the bone marrow, achieving 93% reduction. These findings suggest the possible role of CXCR4 in NHL progression and response to rituximab and provide the scientific basis for the development of novel CXCR4-targeted therapies for refractory NHL. ©2013 AACR.

  18. 原发性高血压患者血清IGF-Ⅱ和血浆GMP-140检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    温江涛

    2009-01-01

    @@ 胰岛素样生长因子包括IGF-Ⅰ和IGF-Ⅱ,属同源的相关性多肽[1] GMP-140又称P选择素,位于血小板α-颗粒膜上和内皮细胞 Weibel-Palade小体中,分子学研究方法已证实人体内存在跨膜及可溶性两种形式的GMP-140[2].

  19. Physiological responses in roots of the grapevine rootstock 140 Ruggeri subjected to Fe deficiency and Fe-heme nutrition.

    Science.gov (United States)

    López-Rayo, Sandra; Di Foggia, Michele; Rodrigues Moreira, Erica; Donnini, Silvia; Bombai, Giuseppe; Filippini, Gianfranco; Pisi, Annamaria; Rombolà, Adamo D

    2015-11-01

    Iron (Fe)-heme containing fertilizers can effectively prevent Fe deficiency. This paper aims to investigate root physiological responses after a short period of Fe-heme nutrition and Fe deficiency under two pH conditions (with or without HEPES) in the Fe chlorosis-tolerant grapevine rootstock 140 Ruggeri. Organic acids in root exudates, Fe reduction capacity, both roots and root exudates contributions, together with other physiological parameters associated to plant Fe status were evaluated in plants grown in hydroponics. Analyses of root tips by SEM, and Raman and IR spectra of the precipitates of Fe-heme fertilizers were performed. The physiological responses adopted by the tolerant 140 Ruggeri to the application of Fe-heme indicated an increased Fe reduction capacity of the roots. This is the first report showing oxalic, tartaric, malic and ascorbic as major organic acids in Vitis spp. root exudates. Plants reacted to Fe deficiency condition exuding a higher amount of ascorbic acid in the rhizosphere. The presence of HEPES in the medium favoured the malic acid exudation. The lowest concentration of oxalic acid was found in exudates of plants subjected to Fe-heme and could be associated to a higher accumulation in their root tips visualized by SEM analysis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Reconstruction of precipitation in the last 140 years from tree ring at south margin of the Tengger Desert, China

    Institute of Scientific and Technical Information of China (English)

    GAO Shangyu; LU Ruijie; QIANG Mingrui; HASI Eerdun; ZHANG Dengshan; CHEN Yuan; XIA Hong

    2005-01-01

    Based on the tree ring width index of Pinus tabulaeformis, precipitation in the last 140 years was reconstructed at south margin of the Tengger Desert. The results indicated that there were obvious fluctuations of dry-wet changes in precipitation: two wet periods occurred during 1868-1876 and 1932-1939, and two dry periods during 1877-1894 and 1924-1932, however, the years 1887 and 1888 were a little wet. There were small changes in precipitation during 1895-1923 and 1940-2000. As compared to the average, the maximum increasing range of precipitation amounted to 56% during the wet periods, and 42% during the dry periods. And the range of variability of precipitation exceeded 30% in 19 years. There was no obvious consistent drying or wetting trend in the last 140 years. But since 1940 fluctuating scope of precipitation tended to be smaller, while the frequency of the fluctuation tended to be larger. Power spectrum analyses suggested that precipitation of south margin of the Tengger Desert had significant periodicities of 2.46-2.64 a and quasi periodicity of 11.67 a.

  1. Placental blood transfusion in newborn babies reaches a plateau after 140 s: Further analysis of longitudinal survey of weight change

    Directory of Open Access Journals (Sweden)

    Graham R Law

    2013-09-01

    Full Text Available Objective: With the introduction of active management of the third stage of labour in the 1960s, it became usual practice to clamp and cut the umbilical cord immediately following birth. The timing of this cord clamping is controversial, as blood may beneficially be transferred to the baby if clamping of the cord is delayed slightly. There is no agreement, however, on how long the delay should be before clamping the cord. This study aimed to establish when blood ceased to flow in the umbilical cord to determine how long to delay clamping of the umbilical cord following delivery of the term newborn to maximise placental transfusion. Methods: This observational study collected longitudinal weight measurements set in a hospital labour ward. A total of 26 mothers at term and their singleton babies participated in the study. In this reanalysis, the velocity of weight change over the first minutes of life determined by functional data analysis was estimated. Results: We found that the flow velocity in the umbilical cord was on average 0 at 125 s after placing the baby on the scales, which was typically 140 s after birth. Conclusions: To maximise placental transfusion, cord clamping should be delayed for at least 140 s following birth of the baby.

  2. Line profiles of water for the photon dominated region and embedded sources in the S140 region

    CERN Document Server

    Poelman, D R

    2006-01-01

    A radiative transfer method for the treatment of molecular lines is presented. We apply this method to previous SWAS and ISO observations of water vapor in the source S140 in order to make models to plan for, and to interpret, HIFI data. Level populations are calculated with the use of a three-dimensional (multi-zone) escape probability method and with a long characteristic code that uses Monte Carlo techniques with fixed directions. Homogeneous and inhomogeneous models are used to compute the differences between water line profiles across the S140 region. We find that when an outflow or infall velocity field with a gradient of a few kms^{-1} is adopted, line profiles with a FWHM of 6 kms^{-1} are found, in agreement with observations. Inhomogeneous models are favoured to produce a single-peaked line profile. When zooming in on smaller regions within the PDR, the shapes of the line profiles start to differ due to the different temperature and density distributions there. The embedded sources are traced by hig...

  3. T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response

    Science.gov (United States)

    Knox, James J.; Buggert, Marcus; Kardava, Lela; Seaton, Kelly E.; Eller, Michael A.; Canaday, David H.; Robb, Merlin L.; Ostrowski, Mario A.; Slifka, Mark K.; Tomaras, Georgia D.; Moir, Susan; Moody, M. Anthony; Betts, Michael R.

    2017-01-01

    Humoral immunity is critical for viral control, but the identity and mechanisms regulating human antiviral B cells are unclear. Here, we characterized human B cells expressing T-bet and analyzed their dynamics during viral infections. T-bet+ B cells demonstrated an activated phenotype, a distinct transcriptional profile, and were enriched for expression of the antiviral immunoglobulin isotypes IgG1 and IgG3. T-bet+ B cells expanded following yellow fever virus and vaccinia virus vaccinations and also during early acute HIV infection. Viremic HIV-infected individuals maintained a large T-bet+ B cell population during chronic infection that was associated with increased serum and cell-associated IgG1 and IgG3 expression. The HIV gp140–specific B cell response was dominated by T-bet–expressing memory B cells, and we observed a concomitant biasing of gp140-specific serum immunoglobulin to the IgG1 isotype. These findings suggest that T-bet induction promotes antiviral immunoglobulin isotype switching and development of a distinct T-bet+ B cell subset that is maintained by viremia and coordinates the HIV Env–specific humoral response. PMID:28422752

  4. Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.

    Science.gov (United States)

    Ashraf, Saquib; Noguera, Nélida I; Di Giandomenico, Jonny; Zaza, Serena; Hasan, Syed Khizer; Lo-Coco, Francesco

    2013-10-01

    NADP-dependent enzyme isocitrate dehydrogenase (IDH) mutations, IDH1 and IDH2, have been described in acute myeloid leukemia (AML) using next generation sequencing approaches. IDH2 mutations are heterozygous; they alter a single arginine residue at position 140 or 172 and have distinct prognostic significance. The current detection methods of IDH2 mutations are laborious and time consuming as they require DNA sequencing. Herein, we report a new allele-specific oligonucleotide-polymerase chain reaction (ASO-PCR) method to detect the IDH2 mutations. Analysis of leukemic DNA samples from 120 AML patients enabled to identify IDH2 mutations in 22 cases which were confirmed by direct DNA sequencing. Of these, 17 harbored IDH2 (R140Q) and 5 IDH2 (R172K) mutations. Serial dilution experiments showed that the assay enable to detect mutations in 10⁻³ dilutions. Our ASO-PCR method appears useful for routine diagnostic screening of these prognostically relevant alterations in AML and may be conveniently included in the diagnostic workup.

  5. Preventive Effects of Rhodosin and Melatonin from Damage Induced by β-Amyloid1-40 in Senile Rats

    Institute of Scientific and Technical Information of China (English)

    XIEGui-qin; SUNXiu-lan; TIANSu-ping; CHENQi-sheng

    2004-01-01

    Objective: To study the protective and therapeutic effects of Rhodosin and Melatonin on Alzheimers disease(AD) rats. Methods: D-galactose was intraperitoneally injected in rats for 6 weeks and β-Amyloid1-40(Aβ1-40) was injected into bilateral hippocampus to make AD models. Rhodosin and Melatonin were intraperitoneally injected in rats for 4 weeks to determine the protective and therapeutic effects on rats with AD. Y-maze test, and passive avoidance task were used to determine the ability of learning and memory. The content of lipofuscin in the central cortex, the viscous coefficient of mitochondrial membrane, the activity of superoxide dismutase and the content of malondialdehyde in both sides of hippocampus were determined. And the apoptosis of hippocampus neurons was determined with transmission electron microscopy(TEM). Results: Melatonin as an antioxidant significantly improved learning and memory deficits in the rats with AD and reduced the increase in SOD, MDA, the viscous coefficient and lipofuscin to their normal levels, and it also showed the protective effects of apoptosis. Rhodosin showed the similar effects. Conclusion: Rhodosin and Melatonin had preventive and therapeutic effects on rats with AD probably by affecting the free radical levels in rats.

  6. Inverse correlation of expression of microRNA-140-5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells.

    Science.gov (United States)

    Guan, Hongbing; Singh, Udai P; Rao, Roshni; Mrelashvili, Davit; Sen, Souvik; Hao, Haiping; Zumbrun, Elizabeth E; Singh, Narendra P; Nagarkatti, Prakash S; Nagarkatti, Mitzi

    2016-04-01

    The role of microRNA in the regulation of encephalitogenic T-cell development is of interest in understanding the pathogenesis of multiple sclerosis (MS). Direct binding of microRNAs to their target mRNAs usually suppresses gene expression and facilitates mRNA degradation. In this study, we observed that the expression of several microRNAs was significantly altered in patients with MS. Interestingly, the expression of miR-140-5p, among other microRNAs, was significantly decreased in the peripheral blood mononuclear cells of patients with MS, and this microRNA may regulate encephalitogenic T helper type 1 (Th1) cell differentiation. The expression level of miR-140-5p was inversely correlated with disease severity with greater reduction in relapsing disease compared with remitting disease. Transfection of synthetic miR-140-5p in peripheral blood mononuclear cells suppressed encephalitogenic Th1 differentiation. Signal transducer and activator of transcription 1 (STAT1) was the functional target of miR-140-5p - transfection of the synthetic miR-140-5p suppressed activation of STAT1 and the expression of its downstream target, T-bet. Our results suggested that miR-140-5p is probably involved in the regulation of encephalitogenic T cells in the pathogenesis of MS.

  7. Nuclear structure of 140Te with N = 88: Structural symmetry and asymmetry in Te isotopes with respect to the double-shell closure Z = 50 and N = 82

    CERN Document Server

    Moon, C -B; Lee, C S; Odahara, A; Lozeva, R; Yagi, A; Browne, F; Nishimura, S; Doornenbal, P; Lorusso, G; Söderström, P -A; Sumikama, T; Watanabe, H; Isobe, T; Baba, H; Sakurai, H; Daido, R; Fang, Y; Nishibata, H; Patel, Z; Rice, S; Sinclair, L; Wu, J; Xu, Z Y; Yokoyama, R; Kubo, T; Inabe, N; Suzuki, H; Fukuda, N; Kameda, D; Takeda, H; Ahn, D S; Murai, D; Garrote, F L Bello; Daugas, J M; Didierjean, F; Ideguchi, E; Ishigaki, T; Jung, H S; Komatsubara, T; Kwon, Y K; Morimoto, S; Niikura, M; Nishizuka, I; Tshoo, K

    2015-01-01

    We study for the first time the internal structure of 140Te through the beta-delayed gamma-ray spectroscopy of 140Sb. The very neutron-rich 140Sb, Z = 51 and N = 89, ions were produced by the in-flight fission of 238U beam on a 9Be target at 345 MeV per nucleon at the Radioactive Ion Beam Factory, RIKEN. The half-life and spin-parity of 140Sb are reported as 124(30) ms and (4-), respectively. In addition to the excited states of 140Te produced by the beta-decay branch, the beta-delayed one-neutron and two-neutron emission branches were also established. By identifying the first 2+ and 4+ excited states of 140Te, we found that Te isotopes persist their vibrator character with E(4+)/E(2+) = 2. We discuss the distinctive features manifest in this region, such as valence neutron symmetry and asymmetry, revealed in pairs of isotopes with the same neutron holes and particles with respect to N = 82.

  8. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Li, Weina, E-mail: liweina228@163.com [Department of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032 (China); He, Fei, E-mail: hesili1027@163.com [Department of Hepatic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China)

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  9. 顽咳汤治疗喉源性咳嗽附:140例病例报告%Cough due to Disorder of Throat Treated with Wan-ke Decoction--Attachment 140 Cases Report

    Institute of Scientific and Technical Information of China (English)

    兰学良

    2003-01-01

    目的观察总结自拟顽咳汤对喉源性咳嗽的疗效. 方法将140例患者按2∶1比例,随机分为治疗组和对照组.治疗组口服顽咳汤煎剂,对照组口服青霉素V钾处片、咳平片,口含华素片. 结果治疗组和对照组治愈率分别为75.00%和33.33%,总有效率分别为94.57%和64.58%,其差异比较均有高度统计学意义(P<0.01). 结论顽咳汤是治疗喉源性咳嗽的理想中药方剂.

  10. Epitope characterization and variable region sequence of f1-40, a high-affinity monoclonal antibody to botulinum neurotoxin type a (Hall strain.

    Directory of Open Access Journals (Sweden)

    Miles C Scotcher

    Full Text Available BACKGROUND: Botulism, an often fatal neuroparalytic disease, is caused by botulinum neurotoxins (BoNT which consist of a family of seven serotypes (A-H produced by the anaerobic bacterium Clostridium botulinum. BoNT, considered the most potent biological toxin known, is a 150 kDa protein consisting of a 100 kDa heavy-chain (Hc and a 50 kDa light-chain (Lc. F1-40 is a mouse-derived, IgG1 monoclonal antibody that binds the light chain of BoNT serotype A (BoNT/A and is used in a sensitive immunoassay for toxin detection. We report the fine epitope mapping of F1-40 and the deduced amino acid sequence of the variable regions of the heavy and light chains of the antibody. METHODS AND FINDINGS: To characterize the binding epitope of F1-40, three complementary experimental approaches were selected. Firstly, recombinant peptide fragments of BoNT/A light-chain were used in Western blots to identify the epitope domains. Secondly, a peptide phage-display library was used to identify the specific amino acid sequences. Thirdly, the three-dimensional structure of BoNT/A was examined in silico, and the amino acid sequences determined from the phage-display studies were mapped onto the three-dimensional structure in order to visualize the epitope. F1-40 was found to bind a peptide fragment of BoNT/A, designated L1-3, which spans from T125 to L200. The motif QPDRS was identified by phage-display, and was mapped to a region within L1-3. When the three amino acids Q138, P139 and D140 were all mutated to glycine, binding of F1-40 to the recombinant BoNT/A light chain peptide was abolished. Q-138, P-139 and D-140 form a loop on the external surface of BoNT/A, exposed to solvent and accessible to F1-40 binding. CONCLUSIONS: The epitope of F1-40 was localized to a single exposed loop (ss4, ss5 on the Lc of BoNT. Furthermore amino acids Q138, P139 and D140 forming the tip of the loop appear critical for binding.

  11. Evolução sócio-profissional de 140 pacientes epilépticos submetidos a tratamento medicamentoso The socio-professional evolution of 140 epileptic patients submitted to antiepileptic drug therapy

    Directory of Open Access Journals (Sweden)

    Luís Marques-Assis

    1968-09-01

    Full Text Available É estudada a evolução sócio-profissional de 140 doentes epilépticos, submetidos apenas a tratamento medicamentoso. Foram empregadas drogas de fácil aquisição em nosso meio (barbitúricos, hidantoinatos, primidona e trimetadiona, utilizadas isolada ou combinadamente. No estudo foram consideradas basicamente as atividades escolares, domésticas e profissionais. A evolução sócio-profissional foi estudada em relação às manifestações clínicas, ao tempo de doença, à freqüência das crises e ao padrão eletrencefalográfico. Os resultados, expressos em índices percentuais, permitiram ao autor concluir que na maioria dos pacientes epilépticos, convenientemente tratados do ponto de vista clínico, os problemas sociais e profissionais podem ser corrigidos ou evitados, independentemente de outras medidas especializadas que possam ser postas em prática.The socio-professional evolution of 140 epileptic patients submitted to antiepileptic drug therapy is studied. Only barbiturates, hydantoin, primidone and trimethadione were administered to the patients, isolated or in association. The school, house keeper and professional activities were considered in the investigation. The socio-professional follow-up was investigated regarding to clinic manifestations, time of disease, frequency of seizures and electroencephalographic pattern. The results, analysed in percentage, led the author to the conclusion that in most epileptic patients, adequately controlled with drugs, the social and the professional problems can be avoided.

  12. 140例突发性耳聋患者疗效相关因素的分析%Analysis of effect-correlating factors in 140 patients with sudden deafness

    Institute of Scientific and Technical Information of China (English)

    宋培荣; 林文森; 石志兴; 马恩明

    2012-01-01

    [目的]探讨影响突发性耳聋预后的相关因素.[方法]系统回顾了本科自2007-2010年收治的140例(142耳)突发性耳聋患者的资料.分析突发性耳聋的预后与年龄、初诊时间、治疗前的听力程度、伴发眩晕、耳鸣的关系.[结果]年龄越大,疗效越差;就诊治疗越早,疗效越好;听力损失越重,疗效越差;伴有眩晕症状者,疗效差;伴发耳鸣对突发性耳聋疗效影响不明显.[结论]了解影响突发性耳聋的疗效影响因素,为突发性耳聋的治疗及判断预后提供一定的依据.%[Objective] To explore the correlating factors influencing the prognosis of sudden deafness. [Methods] Data form 140 patients (142 ears) admitted in 2007 to 2010 were systematic reviewed. Relationship between prognosis of sudden deafness and age, time before therapy, residual acoustic sensibility, coexisting dizziness and bombus was analyzed. [Results] The more elder, the therapeutic effect was less; the more earlier the patients were diagnosed, and the therapeutic effect was better; the more serious of hearing losing, the therapeutic effect was less; coexisting dizziness accompanied poor effect; coexisting bombus showed no significant influence. [Conclusion] Understanding the factors influencing the therapeutic effect of sudden deafness can provide the basis for the therapy and prognosis.

  13. Glaciation and Deglaciation Dynamics of Marine Isotope Stage 6 (160 - 140 kyrs BP): Land - Ice - Atmosphere Feedbacks

    Science.gov (United States)

    Colleoni, F.; Krinner, G.; Jakobsson, M.

    2008-12-01

    During the Late Quaternary, the Northern hemisphere has been affected by several glaciations and the ice sheet extents in Eurasia during these glaciations have recently been reconstructed by the Quaternary Environment of the Eurasian North (QUEEN) project (Svendsen et al. 2004). The QUEEN reconstruction of the peak Saalian (140 kyrs BP) ice sheet during Marine Isotope Stage 6 extends much more eastward and southward than the ice sheet during the Last Glacial Maximum (21 kyrs BP). However, this difference in spatial extent can be explained neither by the orbital parameters nor by the greenhouse gases that were similar during the LGM and the Late Saalian. To better understand how this Late Saalian Eurasian ice sheet could have developed so large and remained stable, our work focuses on the sensitivity of its surface mass balance to the regional parameters: dust deposition on snow, proglacial lakes (Colleoni et al., submitted, 2008a), vegetation cover (Colleoni et al., submitted, 2008b), prescribed sea surface conditions and reduced Laurentide ice volume. These regional parameters have been derived for the Late Saalian in part by adapting geological reconstructions for the Last Glacial Maximum since few geological records exist for the Late Saalian. We use an AGCM model (LMDZ4, Hourdin et al. 2006) to perform the climate and surface mass balance calculations. An asynchronous coupling with a 1D vegetation model (BIOME4, Kaplan et al., 2004) is carried out to create steady-state vegetation covers for our simulated period. References: Colleoni F., and coauthors, Influence of dust deposition and proglacial lakes on the surface mass balance of the Eurasian ice sheet during the peak Saalian (140 kya), Global and Planetary Change, submitted. Colleoni and Krinner, Sensitivity of the Late Saalian (140 kyrs BP) and LGM (21 kyrs BP) Eurasian ice sheet surface mass balance to vegetation feedbacks, GRL, submitted F. Hourdin and coauthors, The LMDZ4 general circulation model

  14. Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ(1-40)) administration in mice.

    Science.gov (United States)

    dos Santos, Vanessa V; Santos, Danúbia B; Lach, Gilliard; Rodrigues, Ana Lúcia S; Farina, Marcelo; De Lima, Thereza C M; Prediger, Rui Daniel

    2013-05-01

    Neuropeptide Y (NPY) is a 36-amino acid peptide widely distributed in the central nervous system (CNS) that has been associated with the modulation of several functions including food intake, learning and memory, mood and neuroprotection. There is great interest in understanding the role of NPY in the deleterious effects induced by the central accumulation of amyloid-β (Aβ) peptides, a pathological hallmark of Alzheimer's disease (AD). Herein, we evaluated the effects of a single intracerebroventricular (i.c.v.) administration of NPY (0.0234 μmol/μL) 15 min prior to the i.c.v. injection of aggregated Aβ1-40 peptide (400 pmol/mouse) in behavioral and neurochemical parameters related to oxidative stress in mice. Pretreatment with NPY prevented Aβ1-40-induced depressive-like responses and spatial memory impairments evaluated in the tail suspension and object location tasks, respectively. The protective effects of NPY on spatial memory of Aβ1-40-treated mice were abolished by the pretreatment with the selective Y2 receptor antagonist BIIE0246. On the other hand, the administration of NPY and Aβ1-40 did not alter the performance of the animals in the elevated plus-maze and open field arena, indicating lack of effects on anxiety state and locomotor function. Although Aβ1-40 infusion did not change hippocampal and cortical glutathione peroxidase (GPx) activity and glutathione (GSH) levels, Aβ1-40-infused animals showed an increased lipid peroxidation in hippocampus and prefrontal cortex that were blunted by NPY administration. These findings indicate that central administration of NPY prevents Aβ1-40-induced depressive-like behavior and spatial memory deficits in mice and that this response is mediated, at least in part, by the activation of Y2 receptors and prevention of oxidative stress.

  15. STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1/SV40 T/t-antigen transgenic mice.

    Directory of Open Access Journals (Sweden)

    Florence Meyer-Losic

    Full Text Available Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX caused by severe dose limiting toxicities, such as neutropenia and peripheral neuropathy. Consequently, new drugs are urgently required. STX140, a compound previously shown to have excellent efficacy against many tumors, is here compared to paclitaxel in three translational in vivo breast cancer models, a rat model of peripheral neuropathy, and through pharmacological testing. Three different in vivo mouse models of breast cancer were used; the metastatic 4T1 orthotopic model, the C3(1/SV40 T-Ag model, and the MDA-MB-231 xenograft model. To determine TIX and pharmacological profile of STX140, a comprehensive dosing regime was performed in mice bearing MDA-MD-231 xenografts. Finally, peripheral neuropathy was examined using a rat plantar thermal hyperalgesia model. In the 4T1 metastatic model, STX140 and paclitaxel significantly inhibited primary tumor growth and lung metastases. All C3(1/SV40 T-Ag mice in the control and paclitaxel treated groups developed palpable mammary cancer. STX140 blocked 47% of tumors developing and significantly inhibited growth of tumors that did develop. STX140 treatment caused a significant (P<0.001 survival advantage for animals in early and late intervention groups. Conversely, in C3(1/SV40 T-Ag mice, paclitaxel failed to inhibit tumor growth and did not increase survival time. Furthermore, paclitaxel, but not STX140, induced significant peripheral neuropathy and neutropenia. These results show that STX140 has a greater anti-cancer efficacy, TIX, and reduced neurotoxicity compared to paclitaxel in C3(1/SV40 T-Ag mice and therefore may be of significant benefit to patients with breast cancer.

  16. Combination of imatinib with CXCR4 antagonist BKT140 overcomes the protective effect of stroma and targets CML in vitro and in vivo.

    Science.gov (United States)

    Beider, Katia; Darash-Yahana, Merav; Blaier, Orly; Koren-Michowitz, Maya; Abraham, Michal; Wald, Hanna; Wald, Ori; Galun, Eithan; Eizenberg, Orly; Peled, Amnon; Nagler, Arnon

    2014-05-01

    Functional role of CXCR4 in chronic myelogenous leukemia (CML) progression was evaluated. Elevated CXCR4 significantly increased the in vitro survival and proliferation in response to CXCL12. CXCR4 stimulation resulted in activation of extracellular signal-regulated kinase (Erk)-1/2, Akt, S6K, STAT3, and STAT5 prosurvival signaling pathways. In accordance, we found that in vitro treatment with CXCR4 antagonist BKT140 directly inhibited the cell growth and induced cell death of CML cells. Combination of BKT140 with suboptimal concentrations of imatinib significantly increased the anti-CML effect. BKT140 induced apoptotic cell death, decreasing the levels of HSP70 and HSP90 chaperones and antiapoptotic proteins BCL-2 and BCL-XL, subsequently promoting the release of mitochondrial factors cytochrome c and SMAC/Diablo. Bone marrow (BM) stromal cells (BMSC) markedly increased the proliferation of CML cells and protected them from imatinib-induced apoptosis. Furthermore, BMSCs elevated proto-oncogene BCL6 expression in the CML cells in response to imatinib treatment, suggesting the possible role of BCL6 in stroma-mediated TKI resistance. BKT140 reversed the protective effect of the stroma, effectively promoted apoptosis, and decreased BCL6 levels in CML cells cocultured with BMSCs. BKT140 administration in vivo effectively reduced the growth of subcutaneous K562-produced xenografts. Moreover, the combination of BKT140 with low-dose imatinib markedly inhibited tumor growth, achieving 95% suppression. Taken together, our data indicate the importance of CXCR4/CXCL12 axis in CML growth and CML-BM stroma interaction. CXCR4 inhibition with BKT140 antagonist efficiently cooperated with imatinib in vitro and in vivo. These results provide the rational basis for CXCR4-targeted therapy in combination with TKI to override drug resistance and suppress residual disease.

  17. STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice.

    Science.gov (United States)

    Meyer-Losic, Florence; Newman, Simon P; Day, Joanna M; Reed, Michael J; Kasprzyk, Philip G; Purohit, Atul; Foster, Paul A

    2013-01-01

    Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX) caused by severe dose limiting toxicities, such as neutropenia and peripheral neuropathy. Consequently, new drugs are urgently required. STX140, a compound previously shown to have excellent efficacy against many tumors, is here compared to paclitaxel in three translational in vivo breast cancer models, a rat model of peripheral neuropathy, and through pharmacological testing. Three different in vivo mouse models of breast cancer were used; the metastatic 4T1 orthotopic model, the C3(1)/SV40 T-Ag model, and the MDA-MB-231 xenograft model. To determine TIX and pharmacological profile of STX140, a comprehensive dosing regime was performed in mice bearing MDA-MD-231 xenografts. Finally, peripheral neuropathy was examined using a rat plantar thermal hyperalgesia model. In the 4T1 metastatic model, STX140 and paclitaxel significantly inhibited primary tumor growth and lung metastases. All C3(1)/SV40 T-Ag mice in the control and paclitaxel treated groups developed palpable mammary cancer. STX140 blocked 47% of tumors developing and significantly inhibited growth of tumors that did develop. STX140 treatment caused a significant (Ptumor growth and did not increase survival time. Furthermore, paclitaxel, but not STX140, induced significant peripheral neuropathy and neutropenia. These results show that STX140 has a greater anti-cancer efficacy, TIX, and reduced neurotoxicity compared to paclitaxel in C3(1)/SV40 T-Ag mice and therefore may be of significant benefit to patients with breast cancer.

  18. Dilatometer setup for low coefficient of thermal expansion materials measurements in the 140 K-250 K temperature range

    Science.gov (United States)

    Spannagel, Ruven; Hamann, Ines; Sanjuan, Josep; Schuldt, Thilo; Gohlke, Martin; Johann, Ulrich; Weise, Dennis; Braxmaier, Claus

    2016-10-01

    Space applications demand light weight materials with excellent dimensional stability for telescopes, optical benches, optical resonators, etc. Glass-ceramics and composite materials can be tuned to reach very low coefficient of thermal expansion (CTE) at different temperatures. In order to determine such CTEs, very accurate setups are needed. Here we present a dilatometer that is able to measure the CTE of a large variety of materials in the temperature range of 140 K to 250 K. The dilatometer is based on a heterodyne interferometer with nanometer noise levels to measure the expansion of a sample when applying small amplitude controlled temperature signals. In this article, the CTE of a carbon fiber reinforced polymer sample has been determined with an accuracy in the 10-8 K-1 range.

  19. Effects of Symmetry Energy in the Reaction 40Ca+124Sn at 140 MeV/nucleon

    CERN Document Server

    Zhang, Fang; Yong, Gao-Chan; Zuo, Wei

    2012-01-01

    The density-dependent symmetry energy is a hot topic in nuclear physics. Many laboratories over the world are planning to perform related experiments to probe the symmetry energy. Based on the semiclassical Boltzmann-Uehling-Uhlenbeck (BUU) transport model, we study the effects of nuclear symmetry energy in the central reaction 40Ca+124Sn at 140MeV/nucleon in the laboratory system. It is found that the rapidity distribution of free nucleon's neutron-to-proton ratio is sensitive to the symmetry energy, especially at large rapidities. The free neutron-to-proton ratios at small or large rapidities may reflect high or low density behavior of nuclear symmetry energy. To probe the density dependence of nuclear symmetry energy, it is better to give the kinetic distribution and the rapidity distribution of emitted nucleons at the same time.

  20. Long-time temperature variations in Portugal over the last 140 years and the effect of the solar activity

    CERN Document Server

    Morozova, A L; Pais, M A

    2010-01-01

    We present the analysis of temperature variations in Portugal for 140 years (from 1865 to 2005). The two stations with the longest time series of temperature measurements (Lisbon and Coimbra) have been used to study the dependence of the portuguese climate variations on the changes of both global circulation and solar activity. Monthly averaged temperature series have been analyzed together with monthly North-Atlantic Oscillation index data, sunspot numbers and cosmic ray flux intensity. Different statistical methods (the correlation analysis and the multiple regression analysis) were used. Our results show that the temperature in Portugal depends not only on the atmospheric variations in the studied region but also on the variations of the solar parameters such as sunspot numbers and the cosmic rays flux intensity. Also, the dependence of temperature on solar parameters is strong during the cold season (November to February), while much weaker during the warm season. For some months, strong correlations betw...

  1. FY-15 Progress Report on Cleanup of irradiated SHINE Target Solutions Containing 140g-U/L Uranyl Sulfate

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Megan E. [Argonne National Lab. (ANL), Argonne, IL (United States); Bowers, Delbert L. [Argonne National Lab. (ANL), Argonne, IL (United States); Vandegrift, George F. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    During FY 2012 and 2013, a process was developed to convert the SHINE Target Solution (STS) of irradiated uranyl sulfate (140 g U/L) to uranyl nitrate. This process is necessary so that the uranium solution can be processed by the UREX (Uranium Extraction) separation process, which will remove impurities from the uranium so that it can be recycled. The uranyl sulfate solution must contain <0.02 M SO42- so that the uranium will be extractable into the UREXsolvent. In addition, it is desired that the barium content be below 0.0007 M, as this is the limit in the Resource Conservation and Recovery Act (RCRA).

  2. Novel large heteropolymetalate complexes formed from Ni(II) and cryptate [As4W40O140]28-

    Institute of Scientific and Technical Information of China (English)

    XUE; Ganglin; (

    2003-01-01

    [1]Rhule, J. T., Hill, C. L., Tudd, D. A. et al., Polyoxometalates in medicine, Chem. Rev., 1998, 98: 327-357.[2]Pope, M. T., Müller, A., Polyoxometellates: from Platonic Solids to Antiretro-Viral Activity, Kluver: Dordrecht, 1994, 245-371.[3]Ouahab, L., Organic/inorganic supramolecular assemblies and synergy between physical properties, Chem. Mater., 1997, 9: 1909-1926.[4]Baker, L. C. W., Glick, D. C., Present general status of understanding of heteropoly electrolytes and a tracing of some major highlights in the history of their elucidation, Chem. Rev., 1998, 98: 3-49.[5]Hill, C. L., Prosser-Mclartha, C. M., Homogeneous catalysis by transition metal oxygen anion clusters, Coordination Chemistry Reviews, 1995, 143: 407-455.[6]Liu Jingfu, Guo Jun, Zhao Beng et al., Synthesis and characterization of novel heteropolytungstoarsenate containing lanthanum [LaAs4W40O140]25- and its derivatives [LaAs4W40O140M2]n-[J], Transition Met. Chem., 1993, 18: 205-208.[7]Wassermann, K., Pope, M. T., Large cluster formation though multiple substitution with lanthanide cations (La, Ce, Nd, Sm, Eu, and Gd) of the polyoxoanion [(B-a-AsO3W9O30)4(WO2)4]28-: Synthesis and structural characterization, Inorg. Chem., 2001, 40: 2763-2768.[8]Xue Ganglin, A new large heteropolyanion [As4W40O140Ce(H2O)5]25-, Acta Chimica Sinica (in Chinese), 2001, 59: 1519-1521.[9]Robert, F., Leyrie, M., Herve, G. et al., Crystal structure of ammonium dicobalto (II)-40-tungstotetraarsenate (III): Allosteric effects in the ligand, lnorg. Chem., 1980, 19: 1746-1752.[10]Hur, N. H., Klemperer, W. G., Wang, R. C. et al., Sodium tetracontatungstotetraarsenate (III), Na27[NaAs4W40O140]@ 60H2O, Inorganic Synthesis, 1990, 27: 118-119.[11]Xu Jiqing, Wang Renzhang, Guo Chunxiao et al., Hydrothermal synthesis, structure and quantum chemistry of transition metal complex supported by metal-oxo cluster [{Ni(phen)2}2 (ξ-Mo8O26)], Science in China, Series B, 2001, 44(2): 137-146.[12

  3. Failure investigation of a secondary super heater tube in a 140 MW thermal power plant

    Directory of Open Access Journals (Sweden)

    Atanu Saha

    2017-04-01

    Full Text Available This article describes the findings of a detailed investigation into the failure of a secondary super heater tube in a 140 MW thermal power plant. Preliminary macroscopic examinations along with visual examination, dimensional measurement and chemical analysis were carried out to deduce the probable cause of failure. In addition optical microscopy was a necessary supplement to understand the cause of failure. It was concluded that the tube had failed due to severe creep damage caused by high metal temperature during service. The probable causes of high metal temperature may be in sufficient flow of steam due to partial blockage, presence of thick oxide scale on ID surface, high flue gas temperature etc. rupture.

  4. In-beam study of the doubly-odd nucleus sub 61 sup 140 Pm sub 79

    Energy Technology Data Exchange (ETDEWEB)

    De Angelis, G.; Gargano, A.; Terrasi, F. (Naples Univ. (Italy). Dipt. di Scienze Fisiche; Istituto Nazionale di Fisica Nucleare, Naples (Italy)); Bazzacco, D.; Lunardi, S.; Maglione, E.; Soramel, F. (Padua Univ. (Italy). Dipt. di Fisica; Istituto Nazionale di Fisica Nucleare, Padua (Italy)); De Poli, M. (Istituto Nazionale di Fisica Nucleare, Padua (Italy). Lab. di Legnaro); Nardelli, G. (Venice Univ. (Italy). Dipt. di Chimica Fisica)

    1989-10-01

    An in-beam {gamma}-ray study performed with the {sup 114}Cd({sup 30}Si,p3n) reaction has established in the high-spin states up to 5 MeV excitation energy and I=(21)h in the N=79 nucleus {sup 140}Pm. The low energy part of the level scheme shows both positive and negative parity states which are interpreted as single particle excitations in the 2d{sub 5/2} and 1h{sub 11/2} orbitals. The level scheme is in qualitative agreement with the coupling of the odd particles to the known yrast levels of the appropriate core nuclei. (orig.).

  5. Measurement of Velocity and Temperature Profiles in the 1/40 Scaled-Down CANDU-6 Moderator Tank

    Directory of Open Access Journals (Sweden)

    Hyoung Tae Kim

    2015-01-01

    Full Text Available In order to simulate the CANDU-6 moderator circulation phenomena during steady state operating and accident conditions, a scaled-down moderator test facility has been constructed at Korea Atomic Energy Institute (KAERI. In the present work an experiment using a 1/40 scaled-down moderator tank has been performed to identify the potential problems of the flow visualization and measurement in the scaled-down moderator test facility. With a transparent moderator tank model, a flow field is visualized with a particle image velocimetry (PIV technique under an isothermal state, and the temperature field is measured using a laser induced fluorescence (LIF technique. A preliminary CFD analysis is also performed to find out the flow, thermal, and heating boundary conditions with which the various flow patterns expected in the prototype CANDU-6 moderator tank can be reproduced in the experiment.

  6. Superdeformed rotational bands in the A ˜ 140-150 mass region: A cranked relativistic mean field description

    Science.gov (United States)

    Afanasjev, A. V.; König, J.; Ring, P.

    1996-02-01

    The cranked relativistic mean field approach is applied for a systematic investigation of superdeformed rotational bands observed in the A ˜ 140-150 mass region. The present investigation covers yrast and in some cases also excited superdeformed bands of all nuclei of this mass region in which such bands have been observed so far. Using the parameter set NL1, which has been adjusted ten years ago to a few spherical nuclei, reasonable agreement with experimental data is obtained throughout the mass region under investigation. It is shown that the calculated properties of superdeformed rotational bands such as the dependence of the dynamic moment of inertia J(2) with respect to the rotational frequency and the absolute value of the charge quadrupole moment Q0 depends sensitively on the number of occupied high- N intruder orbitals. This is agreement both with previous investigations within the cranked Nilsson-Strutinsky and the cranked Woods-Saxon-Strutinsky approaches and with available experimental data.

  7. A comparative analysis of conventional and SurePath liquid-based cervicovaginal cytology: A study of 140 cases

    Directory of Open Access Journals (Sweden)

    Jyotsna Sharma

    2016-01-01

    Full Text Available Background: The role of Papanicolaou (Pap test in cervical cancer screening need not be overemphasized. While most Western countries have adopted the liquid-based cytology (LBC, which is considered superior, many developing countries are still using the conventional Pap smear (CPS technique. Objective: To compare the staining and cytomorphological features on conventional versus liquid-based cervicovaginal smears. Materials and Methods: One hundred and forty cervicovaginal smears prepared by the standard conventional and LBC techniques were interpreted as per the Bethesda system of reporting cervicovaginal smears. Twelve parameters were studied, compared, and statistically analyzed. A P value <0.05 was considered to be statistically significant. Results: 129/140 (92% of CPSs and 130/140 (93% LBC smears were satisfactory. LBC had a significantly shorter screening time (2.0 ± 0.08 vs 4.0 ± 0.65 and better representative material than that of CPS (50% vs 42%. Neutrophils were significantly more in CPS than LBC (96% vs 92% with a P value <0.05 while hemorrhagic background and red blood cells (RBCs were more prominent in CPS. LBC showed significant artifactual changes in squamous epithelial cells. Epithelial abnormalities ranging from atypical squamous cells of undetermined significance (ASCUS to high grade squamous intraepithelial lesion (HSIL were seen in 3% (4 and 2% (2 of CPSs and LBCs, respectively. Organisms were better picked up in CPS (99% in CPS vs 73% LBC with a value of P = 0.0001. Conclusion: Although a shorter screening time and cleaner background are the major advantages of LBC, CPS is not inferior to LBC. Considering the high cost, rather than the advantages associated with LBC, we feel that CPS is a better option for developing countries.

  8. Liquiritigenin inhibits Aβ25-35-induced neurotoxicity and secretion of Aβ1-40 in rat hippocampal neurons

    Institute of Scientific and Technical Information of China (English)

    Rui-ting LIU; Li-bo ZOU; Qiu-jun L(U)

    2009-01-01

    Aim:To examine whether liquiritigenin,a newly found agonist of selective estrogen receptor-13,has neuroprotective activity against βamyloid peptide (Aβ) in rat hippocampal neurons.Methods:Primary cultures of rat hippocampal neurons were pretreated with liquiritigenin (0.02,0.2,and 2 μmol/L) prior to Aβ25-35 exposure.Following treatment,viability of the cells was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide analysis and by a lactate dehydrogenase activity-based cytotoxicity assay.Intracellular Ca2+ concentration ([Ca2+]i) and levels of reactive oxygen species (ROS),as well as apoptotic rates,were determined.Our studies were extended in tests of whether liquiritigenin treatment could inhibit the secretion of Aβ1-40 as measured using an ELISA method.In order to analyze which genes may be involved,we used a microarray assay to compare gene expression patterns.Finally,the levels of specific proteins related to neurotrophy and neurodenegeration were detected by Western blotting.Results:Pretreated neurons with liquiritigenin in the presence of Aβ25-35 increased cell viability in a concentration-dependent manner.Liquiritigenin treatment also attenuated Aβ25-35-induced increases in [Ca2+]i and ROS level and decreased the apoptotic rate of neurons.Some genes,including B-cell lymphoma/leukemia-2 (Bcl-2),neurotrophin 3 (Ntf-3) and amyloid β (A4) precursor protein-binding.family 8,member 1 (Apbb-1) were regulated by liquiritigenin;similar results were shown at the protein level by Western blotting.Conclusion:Our results demonstrate that liquiritigenin exhibits neuroprotective effects against Aβ25-35-induced neurotoxicity and that it can decrease the secretion of Aβ1-40 Therefore,liquiritigenin may be useful for further study as a prodrug for treatment of Alzheimer's disease.

  9. Identification of an amino acid sequence motif in the cytoplasmic domain of the NCAM-140 kDa isoform essential for its neuritogenic activity

    DEFF Research Database (Denmark)

    Kolkova, K; Pedersen, N; Berezin, V;

    2000-01-01

    that expression of cytNCAM-180 had no effect on NCAM-stimulated neuritogenesis, whereas expression of cytNCAM-140 strongly inhibited this process. However, if MEK2 was expressed concomitantly with cytNCAM-140, neurite outgrowth was rescued, indicating that cytNCAM-140 is involved in signaling via the Ras...... (cytNCAM-140) and of the 180-kDa NCAM isoform (cytNCAM-180) in NCAM-induced neurite extension by estimating NCAM-dependent neurite outgrowth from PC12-E2 cells grown in coculture with NCAM-negative or NCAM-positive fibroblasts. PC12-E2 cells were transiently transfected with expression plasmids...... encoding cytNCAM-140, cytNCAM-180, the constitutively active form of the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase (MEK2), and the enhanced variant of the green fluorescent protein (EGFP). EGFP expression was used for identification of transfected cells. We found...

  10. Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.

    Science.gov (United States)

    Rising, Aaron C; Xu, Jia; Carlson, Aaron; Napoli, Vincent V; Denovan-Wright, Eileen M; Mandel, Ronald J

    2011-04-01

    The discovery of the gene mutation responsible for Huntington's disease (HD), huntingtin, in 1993 allowed for a better understanding of the pathology of and enabled the development of animal models. HD is caused by the expansion of a polyglutamine repeat region in the N-terminal of the huntingtin protein. Here we examine the behavioral, transcriptional, histopathological and anatomical characteristics of a knock-in HD mouse model with a 140 polyglutamine expansion in the huntingtin protein. This CAG 140 model contains a portion of the human exon 1 with 140 CAG repeats knocked into the mouse huntingtin gene. We have longitudinally examined the rearing behavior, accelerating rotarod, constant speed rotarod and gait for age-matched heterozygote, homozygote and non-transgenic mice and have found a significant difference in the afflicted mice. However, while there were significant differences between the non-transgenic and the knock-in mice, these behaviors were not progressive. As in HD, we show that the CAG 140 mice also have a significant decrease in striatally enriched mRNA transcripts. In addition, striatal neuronal intranuclear inclusion density increases with age. Lastly these CAG 140 mice show slight cortical thinning compared to non-transgenic mice, similarly to the cortical thinning recently reported in HD.

  11. Human Non-Hematopoietic CD271pos/CD140alow/neg Bone Marrow Stroma Cells Fulfill Stringent Stem Cell Criteria in Serial Transplantations

    Science.gov (United States)

    Ghazanfari, Roshanak; Li, Hongzhe; Zacharaki, Dimitra; Lim, Hooi Ching

    2016-01-01

    Human bone marrow contains a population of non-hematopoietic stromal stem/progenitor cells (BMSCs), which play a central role for bone marrow stroma and the hematopoietic microenvironment. However, the precise characteristics and potential stem cell properties of defined BMSC populations have not yet been thoroughly investigated. Using standard adherent colony-forming unit fibroblast (CFU-F) assays, we have previously shown that BMSCs were highly enriched in the nonhematopoietic CD271pos/CD140alow/neg fraction of normal adult human bone marrow. In this study, we demonstrate that prospectively isolated CD271pos/CD140alow/neg BMSCs expressed high levels of hematopoiesis supporting genes and signature mesenchymal and multipotency genes on a single cell basis. Furthermore, CD271pos/CD140alow/neg BMSCs gave rise to non-adherent sphere colonies (mesenspheres) with typical surface marker profile and trilineage in vitro differentiation potential. Importantly, serial transplantations of CD271pos/CD140alow/neg BMSC-derived mesenspheres (single cell and bulk) into immunodeficient NOD scid gamma (NSG) mice showed increased mesensphere numbers and full differentiation potential after both primary and secondary transplantations. In contrast, BMSC self-renewal potential decreased under standard adherent culture conditions. These data therefore indicate that CD271pos/CD140alow/neg BMSCs represent a population of primary stem cells with MSC phenotype and sphere-forming capacity that fulfill stringent functional stem cell criteria in vivo in a serial transplantation setting. PMID:27527928

  12. Amyloid beta(1-40-induced astrogliosis and the effect of genistein treatment in rat: a three-dimensional confocal morphometric and proteomic study.

    Directory of Open Access Journals (Sweden)

    Maryam Bagheri

    Full Text Available Astrocytes are highly involved in regulation and homeostasis of the extracellular environment in the healthy brain. In pathological conditions, these cells play a major role in the inflammatory response seen in CNS tissues, which is called reactive astrogliosis and includes hypertrophy and proliferation of astrocytes. Here, we performed 3D confocal microscopy to evaluate the morphological response of reactive astrocytes positive for glial fibrillary acidic protein (GFAP in rats, to the presence of Aβ(1-40 in the rat brain before and after treatment with genistein. In 50 astrocytes per animal, we measured the volume and surface area for the nucleus, cell body, the entire cell, the tissue covered by single astrocytes and quantified the number and length of branches, the density of the astrocytes and the intensity of GFAP immunoreactivity. Injecting Aβ(1-40 into the brain of rats caused astrogliosis indicated by increased values for all measured parameters. Mass spectrometric analysis of hippocampal tissue in Aβ(1-40-injected brain showed decreased amounts of tubulins, enolases and myelin basic protein, and increased amounts of dihydropyrimidinase-related protein 2. In Aβ(1-40-injected rats pretreated with genistein, GFAP intensity was decreased to the sham-operated group level, and Aβ(1-40-induced astrogliosis was significantly ameliorated.

  13. Clinical Observation on Modified SiMiao YongAnTang in Treating 140 Cases of Acute Gouty Arthritis%四妙永安汤加味治疗急性痛风性关节炎140

    Institute of Scientific and Technical Information of China (English)

    张勇

    2012-01-01

    目的:观察四妙永安汤加减治疗急性痛风性关节炎的临床疗效.方法:将140 例急性痛风性关节炎患者随机分为2 组.治疗组70 例,予四妙永安汤加减;对照组70 例,予秋水仙碱、苯溴马隆治疗,2 组疗程均为2 周.观察治疗前后病变关节肿胀、疼痛、活动等情况及血尿酸、血沉和C 反应蛋白的变化情况.结果:治疗组与对照组总有效率分别为88.57%、74.29%,不良反应发生率分别为21.43%、58.57%,2组比较有显著性差异(P<0.05).结论:四妙永安汤加减治疗急性痛风性关节炎疗效显著,不良反应发生率较低.%Objective: To observe clinical effects of modified SiMiao YongAnTang in treating acute gouty arthritis. Method: All 140 cases were randomly assigned into treatment group administered with modified SiMiao YongAnTang and control group treated with colchicines and benzbromarone. The session was two weeks for both groups. The conditions of joint swelling, pain, movement and the changes of blood uric acid, erythrocyte sedimentation rate and C reactive protein were observed before and after the treatment. Result: Total effective rate of treatment group was 88.57%, higher than 74.29% of control group with significant difference (P<0.05). Incidence of adverse reaction of treatment group was 21.43%,lower than 58.57% of control group with statistical meaning (P<0.05).Conclusion: Modified SiMiao YongA nTang is effective in treating acute gouty arthritis with low incidence of adverse reaction.

  14. Direct determination of ground-state transition widths of low-lying dipole states in 140Ce with the self-absorption technique

    Directory of Open Access Journals (Sweden)

    C. Romig

    2015-05-01

    Full Text Available The technique of self absorption has been applied for the first time to study the decay pattern of low-lying dipole states of 140Ce. In particular, ground-state transition widths Γ0 and branching ratios Γ0Γ to the ground state have been investigated in the energy domain of the pygmy dipole resonance. Relative self-absorption measurements allow for a model-independent determination of Γ0. Without the need to perform a full spectroscopy of all decay channels, also the branching ratio to the ground state can be determined. The experiment on 140Ce was conducted at the bremsstrahlung facility of the superconducting Darmstadt electron linear accelerator S-DALINAC. In total, the self-absorption and, thus, Γ0 were determined for 104 excited states of 140Ce. The obtained results are presented and discussed with respect to simulations of γ cascades using the DICEBOX code.

  15. Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers

    Science.gov (United States)

    Morris, Charles D.; Azadnia, Parisa; de Val, Natalia; Vora, Nemil; Honda, Andrew; Giang, Erick; Saye-Francisco, Karen; Cheng, Yushao; Lin, Xiaohe; Mann, Colin J.; Tang, Jeffrey; Sok, Devin; Burton, Dennis R.; Law, Mansun; Ward, Andrew B.

    2017-01-01

    ABSTRACT Broadly neutralizing antibodies (bNAbs) have provided valuable insights into the humoral immune response to HIV-1. While rationally designed epitope scaffolds and well-folded gp140 trimers have been proposed as vaccine antigens, a comparative understanding of their antibody responses has not yet been established. In this study, we probed antibody responses to the N332 supersite and the membrane-proximal external region (MPER) in the context of heterologous protein scaffolds and native-like gp140 trimers. Ferritin nanoparticles and fragment crystallizable (Fc) regions were utilized as multivalent carriers to display scaffold antigens with grafted N332 and MPER epitopes, respectively. Trimeric scaffolds were also identified to stabilize the MPER-containing BG505 gp140.681 trimer in a native-like conformation. Following structural and antigenic evaluation, a subset of scaffold and trimer antigens was selected for immunization in BALB/c mice. Serum binding revealed distinct patterns of antibody responses to these two bNAb targets presented in different structural contexts. For example, the N332 nanoparticles elicited glycan epitope-specific antibody responses that could also recognize the native trimer, while a scaffolded BG505 gp140.681 trimer generated a stronger and more rapid antibody response to the trimer apex than its parent gp140.664 trimer. Furthermore, next-generation sequencing (NGS) of mouse splenic B cells revealed expansion of antibody lineages with long heavy-chain complementarity-determining region 3 (HCDR3) loops upon activation by MPER scaffolds, in contrast to the steady repertoires primed by N332 nanoparticles and a soluble gp140.664 trimer. These findings will facilitate the future development of a coherent vaccination strategy that combines both epitope-focused and trimer-based approaches. PMID:28246356

  16. Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140.

    Science.gov (United States)

    Lee, Won-Kyu; Son, Sang Hyeon; Jin, Bong-Suk; Na, Jung-Hyun; Kim, Soo-Youl; Kim, Kook-Han; Kim, Eunice Eunkyeong; Yu, Yeon Gyu; Lee, Hyung Ho

    2013-11-26

    Protein kinase CK2 is a ubiquitous kinase that can phosphorylate hundreds of cellular proteins and plays important roles in cell growth and development. Deregulation of CK2 is related to a variety of human cancers, and CK2 is regarded as a suppressor of apoptosis; therefore, it is a target of anticancer therapy. Nucleolar phosphoprotein 140 (Nopp140), which is an intrinsically disordered protein, interacts with CK2 and inhibits the latter's catalytic activity in vitro. Interestingly, the catalytic activity of CK2 is recovered in the presence of d-myo-inositol 1,2,3,4,5,6-hexakisphosphate (IP6). IP6 is widely distributed in animal cells, but the molecular mechanisms that govern its cellular functions in animal cells have not been completely elucidated. In this study, the crystal structure of CK2 in complex with IP6 showed that the lysine-rich cluster of CK2 plays an important role in binding to IP6. The biochemical experiments revealed that a Nopp140 fragment (residues 568-596) and IP6 competitively bind to the catalytic subunit of CK2 (CK2α), and phospho-Ser574 of Nopp140 significantly enhances its interaction with CK2α. Substitutions of K74E, K76E, and K77E in CK2α significantly reduced the interactions of CK2α with both IP6 and the Nopp140-derived peptide. Our study gives an insight into the regulation of CK2. In particular, our work suggests that CK2 activity is inhibited by Nopp140 and reactivated by IP6 by competitive binding at the substrate recognition site of CK2.

  17. 全身骨显像未确定诊断骨病性质(附140例分析)%Osteopathy Whose Quality Can not be Definitely Diagnosed by Whole Body Bone Imaging (140 Cases Analysis)

    Institute of Scientific and Technical Information of China (English)

    陈曼; 马婧; 李欣欣

    2003-01-01

    目的提高全身骨显像对骨病的诊断准确性和确定诊断率.方法每个病人用99Tcm-MDP进行骨全身显像及局部放大显像.结果 140例不能确定诊断者经过手术、穿刺病理检查,或经复查显像,X线、CT、MRI证实,确定诊断为骨肿瘤78例(41%),骨关节病36例(26%),骨创伤15例(11%),骨结核7例(5%),骨炎症4例(3%).结论全身骨显像表现不典型者一个或两个病灶时仍以肿瘤可能最多,应做为第一考虑,骨关节病病灶多发生在颈、腰椎和膝关节处,有创伤史者考虑骨创伤可能,骨结核和炎症虽为少数也需与肿瘤鉴别.掌握这些规律可以提高全身骨显像诊断的准确性和确诊率.

  18. A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes

    Science.gov (United States)

    Joseph, Sarah; Quinn, Killian; Greenwood, Aldona; Cope, Alethea V.; McKay, Paul F.; Hayes, Peter J.; Kopycinski, Jakub T.; Gilmour, Jill; Miller, Aleisha N.; Geldmacher, Christof; Nadai, Yuka; Ahmed, Mohamed I. M.; Montefiori, David C.; Dally, Len; Bouliotis, George; Lewis, David J. M.; Tatoud, Roger; Wagner, Ralf; Esteban, Mariano; Shattock, Robin J.; McCormack, Sheena; Weber, Jonathan

    2017-01-01

    There remains an urgent need for a prophylactic HIV vaccine. We compared combined MVA and adjuvanted gp140 to sequential MVA/gp140 after DNA priming. We expected Env-specific CD4+ T-cells after DNA and MVA priming, and Env-binding antibodies in 100% individuals after boosting with gp140 and that combined vaccines would not compromise safety and might augment immunogenicity. Forty volunteers were primed three times with DNA plasmids encoding (CN54) env and (ZM96) gag-pol-nef at 0, 4 and 8 weeks then boosted with MVA-C (CN54 env and gag-pol-nef) and glucopyranosyl lipid adjuvant—aqueous formulation (GLA-AF) adjuvanted CN54gp140. They were randomised to receive them in combination at the same visit at 16 and 20 weeks (accelerated) or sequentially with MVA-C at 16, 20, and GLA-AF/gp140 at 24 and 28 weeks (standard). All vaccinations were intramuscular. Primary outcomes included ≥grade 3 safety events and the titer of CN54gp140-specific binding IgG. Other outcomes included neutralization, binding antibody specificity and T-cell responses. Two participants experienced asymptomatic ≥grade 3 transaminitis leading to discontinuation of vaccinations, and three had grade 3 solicited local or systemic reactions. A total of 100% made anti-CN54gp140 IgG and combining vaccines did not significantly alter the response; geometric mean titer 6424 (accelerated) and 6578 (standard); neutralization of MW965.2 Tier 1 pseudovirus was superior in the standard group (82 versus 45% responders, p = 0.04). T-cell ELISpot responses were CD4+ and Env-dominant; 85 and 82% responding in the accelerated and standard groups, respectively. Vaccine-induced IgG responses targeted multiple regions within gp120 with the V3 region most immunodominant and no differences between groups detected. Combining MVA and gp140 vaccines did not result in increased adverse events and did not significantly impact upon the titer of Env-specific binding antibodies, which were seen in 100% individuals

  19. Pages 140 -147.pmd

    African Journals Online (AJOL)

    Administrator

    hypertension (70.6%), those with positive family history of hypertension (59.5%), and diabetes mellitus (46.4%). .... renal disease, female students who were menstruating and within one ... was defined as blood pressure greater than or equal.

  20. 140 ORIGINAL ARTICLE

    African Journals Online (AJOL)

    boaz

    IDENTIFICATION AND DETECTION OF ANTIBIOTIC SUSCEPTIBILITY OF THE MOST. COMMON ANEROBES ..... sequencing and microarrays provide fast and accurate diagnostic ... disturbance, vascular occlusive disease and peripheral ...

  1. Search for excited leptons in e+e- annihilation at √s = 130-140 GeV

    Science.gov (United States)

    Acciarri, M.; Adam, A.; Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.; Alpat, B.; Alcaraz, J.; Allaby, J.; Aloisio, A.; Alverson, G.; Alviggi, M. G.; Ambrosi, G.; Anderhub, H.; Andreev, V. P.; Angelescu, T.; Antreasyan, D.; Arefiev, A.; Azemoon, T.; Aziz, T.; Bagnaia, P.; Baksay, L.; Ball, R. C.; Banerjee, S.; Banicz, K.; Barillère, R.; Barone, L.; Bartalini, P.; Baschirotto, A.; Basile, M.; Battiston, R.; Bay, A.; Becattini, F.; Becker, U.; Behner, F.; Bencze, Gy. L.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B. L.; Biasini, M.; Biland, A.; Bilei, G. M.; Blaising, J. J.; Blyth, S. C.; Bobbink, G. J.; Bock, R.; Böhm, A.; Borgia, B.; Boucham, A.; Bourilkov, D.; Bourquin, M.; Boutigny, D.; Brambilla, E.; Branson, J. G.; Brigljevic, V.; Brock, I. C.; Buijs, A.; Bujak, A.; Burger, J. D.; Burger, W. J.; Burgos, C.; Busenitz, J.; Buytenhuijs, A.; Cai, X. D.; Campanelli, M.; Capell, M.; Cara Romeo, G.; Caria, M.; Carlino, G.; Cartacci, A. M.; Casaus, J.; Castellini, G.; Castello, R.; Cavallari, F.; Cavallo, N.; Cecchi, C.; Cerrada, M.; Cesaroni, F.; Chamizo, M.; Chan, A.; Chang, Y. H.; Chaturvedi, U. K.; Chemarin, M.; Chen, A.; Chen, C.; Chen, G.; Chen, G. M.; Chen, H. F.; Chen, H. S.; Chereau, X.; Chiefari, G.; Chien, C. Y.; Choi, M. T.; Cifarelli, L.; Cindolo, F.; Civinini, C.; Clare, I.; Clare, R.; Coan, T. E.; Cohn, H. O.; Coignet, G.; Colijn, A. P.; Colino, N.; Commichau, V.; Costantini, S.; Cotorobai, F.; de la Cruz, B.; Dai, T. S.; D'Alessandro, R.; de Asmundis, R.; De Boeck, H.; Degré, A.; Deiters, K.; Dénes, E.; Denes, P.; DeNotaristefani, F.; DiBitonto, D.; Diemoz, M.; van Dierendonck, D.; Di Lodovico, F.; Dionisi, C.; Dittmar, M.; Dominguez, A.; Doria, A.; Dorne, I.; Dova, M. T.; Drago, E.; Duchesneau, D.; Duinker, P.; Duran, I.; Dutta, S.; Easo, S.; Efremenko, Yu.; El Mamouni, H.; Engler, A.; Eppling, F. J.; Erné, F. C.; Ernenwein, J. P.; Extermann, P.; Fabbretti, R.; Fabre, M.; Faccini, R.; Falciano, S.; Favara, A.; Fay, J.; Felcini, M.; Ferguson, T.; Fernandez, D.; Fernandez, G.; Ferroni, F.; Fesefeldt, H.; Fiandrini, E.; Field, J. H.; Filthaut, F.; Fisher, P. H.; Forconi, G.; Fredj, L.; Freudenreich, K.; Gailloud, M.; Galaktionov, Yu.; Ganguli, S. N.; Garcia-Abia, P.; Gau, S. S.; Gentile, S.; Gerald, J.; Gheordanescu, N.; Giagu, S.; Goldfarb, S.; Goldstein, J.; Gong, Z. F.; Gonzalez, E.; Gougas, A.; Goujon, D.; Gratta, G.; Gruenewald, M. W.; Gupta, V. K.; Gurtu, A.; Gustafson, H. R.; Gutay, L. J.; Hangarter, K.; Hartmann, B.; Hasan, A.; He, J. T.; Hebbeker, T.; Hervé, A.; van Hoek, W. C.; Hofer, H.; Hoorani, H.; Hou, S. R.; Hu, G.; Ilyas, M. M.; Innocente, V.; Janssen, H.; Jin, B. N.; Jones, L. W.; de Jong, P.; Josa-Mutuberria, I.; Kasser, A.; Khan, R. A.; Kamyshkov, Yu.; Kapinos, P.; Kapustinsky, J. S.; Karyotakis, Y.; Kaur, M.; Kienzle-Focacci, M. N.; Kim, D.; Kim, J. K.; Kim, S. C.; Kim, Y. G.; Kinnison, W. W.; Kirkby, A.; Kirkby, D.; Kirkby, J.; Kittel, W.; Klimentov, A.; König, A. C.; Koffeman, E.; Köngeter, A.; Koutsenko, V.; Koulbardis, A.; Kraemer, R. W.; Kramer, T.; Krenz, W.; Kuijten, H.; Kunin, A.; Ladron de Guevara, P.; Landi, G.; Lapoint, C.; Lassila-Perini, K.; Laurikainen, P.; Lebeau, M.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, J. S.; Lee, K. Y.; Leggett, C.; Le Goff, J. M.; Leiste, R.; Lenti, M.; Leonardi, E.; Levtchenko, P.; Li, C.; Lieb, E.; Lin, W. T.; Linde, F. L.; Lindemann, B.; Lista, L.; Liu, Z. A.; Lohmann, W.; Longo, E.; Lu, W.; Lu, Y. S.; Lübelsmeyer, K.; Luci, C.; Luckey, D.; Ludovici, L.; Luminari, L.; Lustermann, W.; Ma, W. G.; Macchiolo, A.; Maity, M.; Majumder, G.; Malgeri, L.; Malinin, A.; Maña, C.; Mangla, S.; Maolinbay, M.; Marchesini, P.; Marin, A.; Martin, J. P.; Marzano, F.; Massaro, G. G. G.; Mazumdar, K.; McNally, D.; McNeil, R. R.; Mele, S.; Merola, L.; Meschini, M.; Metzger, W. J.; von der Mey, M.; Mi, Y.; Mihul, A.; van Mil, A. J. W.; Mirabelli, G.; Mnich, J.; Möller, M.; Monteleoni, B.; Moore, R.; Morganti, S.; Mount, R.; Müller, S.; Muheim, F.; Nagy, E.; Nahn, S.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Nippe, A.; Nowak, H.; Organtini, G.; Ostonen, R.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Park, H. K.; Pascale, G.; Passaleva, G.; Patricelli, S.; Paul, T.; Pauluzzi, M.; Paus, C.; Pauss, F.; Pei, Y. J.; Pensotti, S.; Perret-Gallix, D.; Petrak, S.; Pevsner, A.; Piccolo, D.; Pieri, M.; Pinto, J. C.; Piroué, P. A.; Pistolesi, E.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Produit, N.; Raghavan, R.; Rahal-Callot, G.; Rancoita, P. G.; Rattaggi, M.; Raven, G.; Razis, P.; Read, K.; Redaelli, M.; Ren, D.; Rescigno, M.; Reucroft, S.; Ricker, A.; Riemann, S.; Riemers, B. C.; Riles, K.; Rind, O.; Ro, S.; Robohm, A.; Rodin, J.; Rodriguez, F. J.; Roe, B. P.; Röhner, S.; Romero, L.; Rosier-Lees, S.; Rosselet, Ph.; van Rossum, W.; Roth, S.; Rubio, J. A.; Rykaczewski, H.; Salicio, J.; Salicio, J. M.; Sanchez, E.; Santocchia, A.; Sarakinos, M. E.; Sarkar, S.; Sassowsky, M.; Schäfer, C.; Schegelsky, V.; Schmidt-Kaerst, S.; Schmitz, D.; Schmitz, P.; Schneegans, M.; Schoeneich, B.; Scholz, N.; Schopper, H.; Schotanus, D. J.; Schulte, R.; Schultze, K.; Schwenke, J.; Schwering, G.; Sciacca, C.; Seiler, P. G.; Sens, J. C.; Servoli, L.; Shevchenko, S.; Shivarov, N.; Shoutko, V.; Shukla, J.; Shumilov, E.; Siedenburg, T.; Son, D.; Sopczak, A.; Soulimov, V.; Smith, B.; Spillantini, P.; Steuer, M.; Stickland, D. P.; Sticozzi, F.; Stone, H.; Stoyanov, B.; Straessner, A.; Strauch, K.; Sudhakar, K.; Sultanov, G.; Sun, L. Z.; Susinno, G. F.; Suter, H.; Swain, J. D.; Tang, X. W.; Tauscher, L.; Taylor, L.; Ting, Samuel C. C.; Ting, S. M.; Toker, O.; Tonisch, F.; Tonutti, M.; Tonwar, S. C.; Tóth, J.; Tsaregorodtsev, A.; Tully, C.; Tuchscherer, H.; Tung, K. L.; Ulbricht, J.; Urbán, L.; Uwer, U.; Valente, E.; Van de Walle, R. T.; Vetlitsky, I.; Viertel, G.; Vivargent, M.; Völkert, R.; Vogel, H.; Vogt, H.; Vorobiev, I.; Vorobyov, A. A.; Vorobyov, An. A.; Vuilleumier, L.; Wadhwa, M.; Wallraff, W.; Wang, J. C.; Wang, X. L.; Wang, Y. F.; Wang, Z. M.; Weber, A.; Weill, R.; Willmott, C.; Wittgenstein, F.; Wu, S. X.; Wynhoff, S.; Xu, J.; Xu, Z. Z.; Yang, B. Z.; Yang, C. G.; Yao, X. Y.; Ye, J. B.; Yeh, S. C.; You, J. M.; Zaccardelli, C.; Zalite, An.; Zemp, P.; Zeng, J. Y.; Zeng, Y.; Zhang, Z.; Zhang, Z. P.; Zhou, B.; Zhou, G. J.; Zhou, Y.; Zhu, G. Y.; Zhu, R. Y.; Zichichi, A.; van der Zwaan, B. C. C.; L3 Collaboration

    1996-02-01

    We report on a search for the excited leptons e ∗, μ ∗, τ ∗ and ν ∗ in e +e - collisions at s = 130-140 GeV using the L3 detector at LEP. No evidence has been found for their existence. From an analysis of the expected pair produced ℓ ∗ℓ ∗ in the channels eeγγ, μμγγ, ττγγ, eeWW, and ννγγ, we determine the lower mass limits at 95% C.L. of 64.7 GeV for e ∗, 64.9 GeV for μ ∗, 64.2 GeV for τ ∗, 57.3 GeV (eW decay mode) and 61.4 GeV (νγ decay mode) for ν ∗. From an analysis of the expected singly produced ℓℓ ∗ in the channels eeγ, μμγ, ττγ, νeW and ννγ, we determine upper limits on the couplings {λ}/{m ℓ ∗} up to m ℓ ∗ = 130 GeV.

  2. Multifrequency Polarimetry of the Nrao 140 Jet: Possible Detection of a Helical Magnetic Field and Constraints on its Pitch Angle

    CERN Document Server

    Asada, Keiichi; Nakamura, Masanori; Kameno, Seiji; Nagai, Hiroshi

    2008-01-01

    We present results from multifrequency polarimetry of NRAO 140 using the Very Long Baseline Array. These observations allow us to reveal the distributions of both the polarization position angle and the Faraday rotation measure (RM). These distributions are powerful tools to discern the projected and line-of-sight components of the magnetic field, respectively. We find a systematic gradient in the RM distribution, with its sign being opposite at either side of the jet with respect to the jet axis. The sign of the RM changes only with the direction of the magnetic field component along the line of sight, so this can be explained by the existence of helical magnetic components associated with the jet itself. We derive two constraints for the pitch angle of the helical magnetic field from the distributions of the RM and the projected magnetic field; the RM distribution indicates that the helical fields are tightly wound, while that of the projected magnetic field suggests they are loosely wound around the jet ax...

  3. First Science Results From SOFIA/FORCAST: Super-Resolution Imaging of the S140 Cluster at 37\\micron

    CERN Document Server

    Harvey, Paul M; Herter, Terry L; Gull, George; Schoenwald, Justin; Keller, Luke D; De Buizer, James M; Vacca, William; Reach, William; Becklin, E E

    2012-01-01

    We present 37\\micron\\ imaging of the S140 complex of infrared sources centered on IRS1 made with the FORCAST camera on SOFIA. These observations are the longest wavelength imaging to resolve clearly the three main sources seen at shorter wavelengths, IRS 1, 2 and 3, and are nearly at the diffraction limit of the 2.5-m telescope. We also obtained a small number of images at 11 and 31\\micron\\ that are useful for flux measurement. Our images cover the area of several strong sub-mm sources seen in the area -- SMM 1, 2, and 3 -- that are not coincident with any mid-infrared sources and are not visible in our longer wavelength imaging either. Our new observations confirm previous estimates of the relative dust optical depth and source luminosity for the components in this likely cluster of early B stars. We also investigate the use of super-resolution to go beyond the basic diffraction limit in imaging on SOFIA and find that the van Cittert algorithm, together with the "multi-resolution" technique, provides excelle...

  4. Dual-Frequency Observations of 140 Compact, Flat-Spectrum Active Galactic Nuclei for Scintillation-Induced Variability

    CERN Document Server

    Koay, J Y; Rickett, B J; Bignall, H E; Lovell, J E J; Reynolds, C; Jauncey, D L; Pursimo, T; Kedziora-Chudczer, L; Ojha, R

    2011-01-01

    The 4.9 GHz Micro-Arcsecond Scintillation-Induced Variability (MASIV) Survey detected a drop in Interstellar Scintillation (ISS) for sources at redshifts z > 2, indicating an apparent increase in angular diameter or a decrease in flux density of the most compact components of these sources, relative to their extended emission. This can result from intrinsic source size effects or scatter broadening in the Intergalactic Medium (IGM), in excess of the expected (1+z)^0.5 angular diameter scaling of brightness temperature limited sources due to cosmological expansion. We report here 4.9 GHz and 8.4 GHz observations and data analysis for a sample of 140 compact, flat-spectrum sources which may allow us to determine the origin of this angular diameter-redshift relation by exploiting their different wavelength dependences. In addition to using ISS as a cosmological probe, the observations provide additional insight into source morphologies and the characteristics of ISS. As in the MASIV Survey, the variability of th...

  5. VLT/NACO Polarimetric Differential Imaging of HD100546 - Disk Structure and Dust Grain Properties between 10-140 AU

    CERN Document Server

    Quanz, Sascha P; Geissler, Kerstin; Meyer, Michael R; Henning, Thomas; Brandner, Wolfgang; Wolf, Sebastian

    2011-01-01

    We present polarimetric differential imaging (PDI) data of the circumstellar disk around the Herbig Ae/Be star HD100546 obtained with VLT/NACO. We resolve the disk in polarized light in the H and Ks filter between ~0.1-1.4" (i.e., ~10-140 AU). The innermost disk regions are directly imaged for the first time and the mean apparent disk inclination and position angle are derived. The surface brightness along the disk major axis drops off roughly with S(r) ~ r^-3 but has a maximum around 0.15" suggesting a marginal detection of the main disk inner rim at ~15 AU. We find a significant brightness asymmetry along the disk minor axis in both filters with the far side of the disk appearing brighter than the near side. This enhanced backward scattering and a low total polarization degree of the scattered disk flux of 14%(+19%/-8%) suggests that the dust grains on the disk surface are larger than typical ISM grains. Empirical scattering functions reveal the backward scattering peak at the largest scattering angles and ...

  6. Abnormal burst patterns of single neurons recorded in the substantia nigra reticulata of behaving 140 CAG Huntington's disease mice.

    Science.gov (United States)

    Murphy-Nakhnikian, Alexander; Dorner, Jenelle L; Fischer, Benjamin I; Bower-Bir, Nathan D; Rebec, George V

    2012-03-14

    Huntington's disease (HD) is an inherited neurodegenerative disorder that causes neurological pathology in the basal ganglia and related circuitry. A key site of HD pathology is striatum, the principal basal ganglia input structure; striatal pathology likely changes basal ganglia output but no existing studies address this issue. In this report, we characterize single-neuron activity in the substantia nigra reticulata (SNr) of awake, freely behaving 140 CAG knock-in (KI) mice at 16-40 weeks. KI mice are a well characterized model of adult HD and are mildly symptomatic in this age range. As the primary basal ganglia output nucleus in rodents, the SNr receives direct innervation from striatum, as well as indirect influence via polysynaptic inputs. We analyzed 32 single neurons recorded from KI animals and 44 from wild-type (WT) controls. We found increased burst rates, without a concordant change in spike discharge rate, in KI animals relative to WTs. Furthermore, although metrics of burst structure, such as the inter-spike interval in bursts, do not differ between groups, burst rate increases with age in KI, but not WT, animals. Our findings suggest that altered basal ganglia output is a physiological feature of early HD pathology.

  7. Protective effect of bradykinin antagonist Hoe-140 during in vivo myocardial ischemic-reperfusion injury in the cat.

    Science.gov (United States)

    Kumari, Rashmi; Maulik, Mohua; Manchanda, Subhash Chandra; Maulik, Subir Kumar

    2003-10-15

    The effect of icatibant (Hoe-140), a selective bradykinin receptor (B(2)) antagonist on myocardial ischemic-reperfusion injury was studied in open chest barbiturate anaesthetized cats. The left anterior descending coronary artery was occluded for 15 min, followed by 60 min of reperfusion. Saline or icatibant (200 microg/kg) was administered intravenously slowly over 2 min, 5 min before reperfusion. In the saline-treated group, myocardial ischemic-reperfusion injury was evidenced by depressed MAP, depressed peak positive and negative dP/dt and elevated left ventricular end-diastolic pressure and enhanced oxidative stress [elevated plasma thiobarbituric acid reactive substances (TBARS; a marker for lipid peroxidation), depressed myocardial GSH (reduced glutathione), superoxide dismutase (SOD), catalase] and depletion of adenosine triphosphate (ATP) along with rise in plasma creatine phosphokinase (CPK). Administration of icatibant resulted in complete hemodynamic recovery together with repletion of ATP and reduction in plasma TBARS without any significant change in myocardial SOD, catalase and GSH. The results of the present study suggest a protective role of icatibant in myocardial ischemic-reperfusion injury.

  8. Differing modes of interaction between monomeric Aβ(1-40) peptides and model lipid membranes: an AFM study.

    Science.gov (United States)

    Sheikh, Khizar; Giordani, Cristiano; McManus, Jennifer J; Hovgaard, Mads Bruun; Jarvis, Suzanne P

    2012-02-01

    Membrane interactions with β-amyloid peptides are implicated in the pathology of Alzheimer's disease and cholesterol has been shown to be key modulator of this interaction, yet little is known about the mechanism of this interaction. Using atomic force microscopy, we investigated the interaction of monomeric Aβ(1-40) peptides with planar mica-supported bilayers composed of DOPC and DPPC containing varying concentrations of cholesterol. We show that below the bilayer melting temperature, Aβ monomers adsorb to, and assemble on, the surface of DPPC bilayers to form layers that grow laterally and normal to the bilayer plane. Above the bilayer melting temperature, we observe protofibril formation. In contrast, in DOPC bilayers, Aβ monomers exhibit a detergent-like action, forming defects in the bilayer structure. The kinetics of both modes of interaction significantly increases with increasing membrane cholesterol content. We conclude that the mode and rate of the interaction of Aβ monomers with lipid bilayers are strongly dependent on lipid composition, phase state and cholesterol content.

  9. How to explain a PaO2 of 140 mmHg in a venous line?

    Science.gov (United States)

    Mizzi, Anna; Landoni, Giovanni; Corno, Laura; Fichera, Mariano; Nuzzi, Massimiliano; Zangrillo, Alberto

    2009-01-01

    Metformin is a commonly used oral antidiabetic drug which can cause lactic acidosis. Although rare, this condition carries a high mortality risk. Correction of metabolic acidaemia is essential for treatment and dialysis with bicarbonate replacement is the gold standard approach. A 53-year-old man with diabetes on metformin therapy was admitted to the intensive care unit with severe lactic acidosis and acute renal failure suggesting metformin intoxication. The lactic acidosis was treated with bicarbonate haemodialysis and his pH normalized after 10 hours, but he died because of myocardial infarction due to severe hypotension. At ICU admission an aortic dissection was also hypothesized but TEE did not evidence aortic dissection. The dilemma in this patient was represented by the abnormal PaO2 value (140 mmHg) in the venous blood gas analysis. Considering that metformin acts on mitochondrial respiration, the dilemma may be explained by hypothesizing a cellular respiration block caused by metformin or severe acidosis. (www.actabiomedica.it)

  10. Past 140-year environmental record in the northern South China Sea: evidence from coral skeletal trace metal variations.

    Science.gov (United States)

    Song, Yinxian; Yu, Kefu; Zhao, Jianxin; Feng, Yuexing; Shi, Qi; Zhang, Huiling; Ayoko, Godwin A; Frost, Ray L

    2014-02-01

    About 140-year changes in the trace metals in Porites coral samples from two locations in the northern South China Sea were investigated. Results of PCA analyses suggest that near the coast, terrestrial input impacted behavior of trace metals by 28.4%, impact of Sea Surface Temperature (SST) was 19.0%, contribution of war and infrastructure were 14.4% and 15.6% respectively. But for a location in the open sea, contribution of War and SST reached 33.2% and 16.5%, while activities of infrastructure and guano exploration reached 13.2% and 14.7%. While the spatiotemporal change model of Cu, Cd and Pb in seawater of the north area of South China Sea during 1986-1997 were reconstructed. It was found that in the sea area Cu and Cd contaminations were distributed near the coast while areas around Sanya, Hainan had high Pb levels because of the well-developed tourism related activities.

  11. A contracting circumbinary molecular ring with an inner cavity of about 140 AU around Ori 139-409

    CERN Document Server

    Zapata, Luis A; Ho, Paul

    2009-01-01

    Sensitive and subarcsecond resolution ($\\sim$ 0.7\\arcsec) CH$_3$OH(7$_{-2,6}$ $\\to$ 6$_{-2,5}$) line and 890 $\\mu$m continuum observations made with the Submillimeter Array (SMA) towards the hot molecular circumbinary ring associated with the young multiple star Ori 139-409 are presented. The CH$_3$OH(7$_{-2,6}$ - 6$_{-2,5}$) emission from the ring is well resolved at this angular resolution revealing an inner cavity with a size of about 140 AU. A LTE model of a Keplerian disk with an inner cavity of the same size confirms the presence of this cavity. Additionally, this model suggests that the circumbinary ring is contracting with a velocity of V$_{inf}$ $\\sim$ 1.5 km s$^{-1}$ toward the binary central compact circumstellar disks reported at a wavelength of 7 mm. {\\bf The inner central cavity seems to be formed by the tidal effects of the young stars in the middle of the ring.} The ring appears to be not a stationary object. Furthermore, the infall velocity we determine is about a factor of 3 slower than the ...

  12. Superdeformed rotational bands in the A{proportional_to}140-150 mass region: a cranked relativistic mean field description

    Energy Technology Data Exchange (ETDEWEB)

    Afanasjev, A.V. [Technische Univ. Muenchen, Garching (Germany). Physik-Department]|[Latvian Acad. of Sci., Salaspils (Latvia). Dept. of Math. Phys.]|[Lund Inst. of Tech. (Sweden). Dept. of Mathematical Physics; Koenig, J. [Technische Univ. Muenchen, Garching (Germany). Physik-Department; Ring, P. [Technische Univ. Muenchen, Garching (Germany). Physik-Department

    1996-10-14

    The cranked relativistic mean field approach is applied for a systematic investigation of superdeformed rotational bands observed in the A {proportional_to}140-150 mass region. The present investigation covers yrast and in some cases also excited superdeformed bands of all nuclei of this mass region in which such bands have been observed so far. Using the parameter set NL1, which has been adjusted ten years ago to a few spherical nuclei, reasonable agreement with experimental data is obtained throughout the mass region under investigation. It is shown that the calculated properties of superdeformed rotational bands such as the dependence of the dynamic moment of inertia J{sup (2)} with respect to the rotational frequency and the absolute value of the charge quadrupole moment Q{sub 0} depends sensitively on the number of occupied high-N intruder orbitals. This is in agreement both with previous investigations within the cranked Nilsson-Strutinsky and the cranked Woods-Saxon-Strutinsky approaches and with available experimental data. (orig.).

  13. Is bronchial wall imaging affected by temporal resolution? Comparative evaluation at 140 and 75 ms in 90 patients

    Energy Technology Data Exchange (ETDEWEB)

    Hutt, Antoine; Tacelli, Nunzia; Faivre, Jean-Baptiste; Remy, Jacques; Remy-Jardin, Martine [CHRU et Universite de Lille, Department of Thoracic Imaging, Hospital Calmette (EA 2694), Lille (France); Flohr, Thomas [Computed Tomography, Siemens Healthcare, Forchheim (Germany); Duhamel, Alain [CHRU et Universite de Lille, Department of Biostatistics (EA 2694), Lille (France)

    2016-02-15

    To evaluate the influence of temporal resolution (TR) on cardiogenic artefacts at the level of bronchial walls. Ninety patients underwent a dual-source, single-energy chest CT examination enabling reconstruction of images with a TR of 75 ms (i.e., optimized TR) (Group 1) and 140 ms (i.e., standard TR) (Group 2). Cardiogenic artefacts were analyzed at the level of eight target bronchi, i.e., right (R) and left (L) B1, B5, B7, and B10 (total number of bronchi examined: n = 720). Cardiogenic artefacts were significantly less frequent and less severe in Group 1 than in Group 2 (p < 0.0001) with the highest scores of discordant ratings for bronchi in close contact with cardiac cavities: RB5 (61/90; 68 %); LB5 (66/90; 73 %); LB7 (63/90; 70 %). In Group 1, 78 % (560/720) of bronchi showed no cardiac motion artefacts, whereas 22 % of bronchi (160/720) showed artefacts rated as mild (152/160; 95 %), moderate (7/160; 4 %), and severe (1/160; 1 %). In Group 2, 70 % of bronchi (503/720) showed artefacts rated as mild (410/503; 82 %), moderate (82/503; 16 %), and severe (11/503; 2 %). At 75 ms, most bronchi can be depicted without cardiogenic artefacts. (orig.)

  14. Photon Dominated Regions in Low UV Fields A Study of The Peripheral Region of L1204\\/S140

    CERN Document Server

    Li, W; Van Dishoeck, E F; Thi, W F; Li, Wenbin; II, Neal J. Evans; Jaffe, Daniel T.; Dishoeck, Ewine F. van; Thi, Wing-Fai

    2001-01-01

    We have carried out an in-depth study of the peripheral region of the molecular cloud L1204/S140, where the far ultraviolet radiation and the density are relatively low. Our observations test theories of photon-dominated regions (PDRs) in a regime that has been little explored. CII 158 micron and OI 63 micron lines are detected by ISO at all 16 positions along a 1-dimensional cut in right ascension. Emission from molecular hydrogen rotational transitions, at 28 and 17 micron, was also detected at several positions. The CII, OI, and molecular hydrogen intensities along the cut show much less spatial variation than do the rotational lines of CO and other CO isotopes. The average CII and OI intensities and their ratio are consistent with models of PDRs with low FUV radiation (Go) and density. The best-fitting model has Go about 15 and density, n about 1000 per cubic cm. Standard PDR models underpredict the intensity in the H2 rotational lines by up to an order of magnitude. This problem has also been seen in bri...

  15. Analysis the Correlative Factors of 140 FGR With Different Gestation Ages%140例胎儿生长受限孕周及相关因素分析

    Institute of Scientific and Technical Information of China (English)

    肖静; 朱付凡

    2011-01-01

    Objective;To discuss the correlative factors of fetal growth restriction before and/or after 32-weeks, S/D ratio, delivery time and routine, and fetal outcomes. Methods; 140 cases diagnosed as FGR from September 2009 to August 2010 in our hospital were retrospectively reviewed and divided into two groups:32 weeks group. Results;The major correlative factors in ≤32 weeks group were gestational hypertension, medical complications, placental factors. The major correlative factors in >32 weeks group were gestational hypertension, umbilical cord factors. Compared with the >32 weeks group, the delivery age, neonatal score and birth weight in the =£32 weeks group were lower(P140例FGR患儿母亲的临床资料,将其分为>32孕周组和≤32孕周组,并对两组资料进行分析.结果:≤32孕周组主要相关因素为妊娠期高血压疾病、内科合并症、胎盘因素;>32孕周组主要相关因素为妊娠期高血压疾病、脐带因素.≤32孕周组分娩孕周、新生儿评分、新生儿体重均低于>32孕周组(P<0.05),而围生儿总死亡率、S/D阳性率、早产率高于>32孕周组(P<0.05).结论:≤32孕周的FGR具有高并发症

  16. Novel large heteropolymetalate complexes formed from Ni(II) and cryptate [As4W40O140]28-Synthesis and structure characterization

    Institute of Scientific and Technical Information of China (English)

    薛岗林; 刘斌; 王文亮; 王继武; 王大奇

    2003-01-01

    The heteropolytungstate (NH4)20[Na2(H2O)2Ni(H2O)5{Ni(H2O)}2As4W40O140]@61H2O is obtained by the reaction of Na27[NaAs4W40O140]@60H2O with NiCl2@6H2O and NH4Cl in pH≈4.0. The structure and chemical composition are determined byX-ray diffraction analysis and element analysis. The crystal data and main structure refinement are: a = 1.33135(18) nm, b = 1.9722(3) nm, c = 3.6430(5) nm, α = 78.010(2)°, β = 82.145(2)°, γ = 74.385(2)°, V = 8.978(2) nm3, triclinic crystal system, space group: P, Z = 2, R1 = 0.0512, and wR2 = 0.0684(I >2σ). The four S2 sites of the big cyclic ligand [As4W40O140]28- are occupied by two Na+ and two Ni2+ respectively, and each site supplies four Od coordinating to metal ion. The coordination number of Ni2+ is six, and that of two Na+ is five and sixrespectively. The third Ni2+ locates outside the cyclic [As4W40O140]28- and connects with one Od, and its coordination number is six.

  17. 8 CFR 1245.18 - How can physicians (with approved Forms I-140) that are serving in medically underserved areas or...

    Science.gov (United States)

    2010-01-01

    ... with a national interest job offer waiver, the aggregate period during which the medical practice... approval of the Form I-140 and of the national interest waiver. (j) Will a Service officer interview the... adjustment interview with a Service officer, unless the Service waives the interview as provided in §...

  18. Integration Tests of the 4 kW-Class High Voltage Hall Accelerator Power Processing Unit with the HiVHAc and the SPT-140 Hall Effect Thrusters

    Science.gov (United States)

    Kamhawi, Hani; Pinero, Luis; Haag, Thomas; Huang, Wensheng; Ahern, Drew; Liang, Ray; Shilo, Vlad

    2016-01-01

    NASA's Science Mission Directorate is sponsoring the development of a 4 kW-class Hall propulsion system for implementation in NASA science and exploration missions. The main components of the system include the High Voltage Hall Accelerator (HiVHAc), an engineering model power processing unit (PPU) developed by Colorado Power Electronics, and a xenon flow control module (XFCM) developed by VACCO Industries. NASA Glenn Research Center is performing integrated tests of the Hall thruster propulsion system. This paper presents results from integrated tests of the PPU and XFCM with the HiVHAc engineering development thruster and a SPT-140 thruster provided by Space System Loral. The results presented in this paper demonstrate thruster discharge initiation along with open-loop and closed-loop control of the discharge current with anode flow for both the HiVHAc and the SPT-140 thrusters. Integrated tests with the SPT-140 thruster indicated that the PPU was able to repeatedly initiate the thruster's discharge, achieve steady state operation, and successfully throttle the thruster between 1.5 and 4.5 kW. The measured SPT-140 performance was identical to levels reported by Space Systems Loral.

  19. Simple Colorimetric Detection of Amyloid β-peptide (1-40) based on Aggregation of Gold Nanoparticles in the Presence of Copper Ions.

    Science.gov (United States)

    Zhou, Yanli; Dong, Hui; Liu, Lantao; Xu, Maotian

    2015-05-13

    A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid-β peptide (Aβ) is developed based on the aggregation of gold nanoparticles in the presence of copper ion. The detection of limit for Aβ(1-40) is 0.6 nM and the promising results from practical samples (human serum) indicate the great potential for the routine detection.

  20. Palynological record of tropical rain forest vegetation and sea level fluctuations since 140 ka from sediment core, south-eastern Arabian sea.

    Digital Repository Service at National Institute of Oceanography (India)

    Farooqui, A.; Pattan, J.N.; Parthiban, G.; Srivastava, J.; Ranjana

    Palyno-chronological study of a 552 cm deep sediment core from the south-eastern Arabian Sea covers a time span of ~ 140 ka. The age estimate is based on oxygen isotopic data of planktic foraminifera. Six zones were identified on the basis...

  1. THE CONTRIBUTION OF RADIO GALAXY CONTAMINATION TO MEASUREMENTS OF THE SUNYAEV-ZEL'DOVICH DECREMENT IN MASSIVE GALAXY CLUSTERS AT 140 GHz WITH BOLOCAM

    Energy Technology Data Exchange (ETDEWEB)

    Sayers, J.; Mroczkowski, T.; Czakon, N. G.; Golwala, S. R.; Downes, T. P.; Muchovej, S. J. C.; Siegel, S. [Division of Physics, Math, and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Mantz, A. [Kavli Institute for Cosmological Physics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Ameglio, S.; Pierpaoli, E.; Shitanishi, J. A. [Department of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089 (United States); Koch, P. M.; Lin, K.-Y.; Umetsu, K. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 10617, Taiwan (China); Molnar, S. M. [LeCosPA Center, National Taiwan University, Taipei 10617, Taiwan (China); Moustakas, L., E-mail: jack@caltech.edu [Jet Propulsion Laboratory, Pasadena, CA 91109 (United States)

    2013-02-20

    We describe in detail our characterization of the compact radio source population in 140 GHz Bolocam observations of a set of 45 massive galaxy clusters. We use a combination of 1.4 and 30 GHz data to select a total of 28 probable cluster-member radio galaxies and also to predict their 140 GHz flux densities. All of these galaxies are steep-spectrum radio sources and they are found preferentially in the cool-core clusters within our sample. In particular, 11 of the 12 brightest cluster-member radio sources are associated with cool-core systems. Although none of the individual galaxies are robustly detected in the Bolocam data, the ensemble-average flux density at 140 GHz is consistent with, but slightly lower than, the extrapolation from lower frequencies assuming a constant spectral index. In addition, our data indicate an intrinsic scatter of {approx_equal} 30% around the power-law extrapolated flux densities at 140 GHz, although our data do not tightly constrain this scatter. For our cluster sample, which is composed of high-mass and moderate-redshift systems, we find that the maximum fractional change in the Sunyaev-Zel'dovich signal integrated over any single cluster due to the presence of these radio sources is {approx_equal} 20%, and only {approx_equal} 1/4 of the clusters show a fractional change of more than 1%. The amount of contamination is strongly dependent on cluster morphology, and nearly all of the clusters with {>=}1% contamination are cool-core systems. This result indicates that radio contamination is not significant compared with current noise levels in 140 GHz images of massive clusters and is in good agreement with the level of radio contamination found in previous results based on lower frequency data or simulations.

  2. The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy.

    Science.gov (United States)

    Renvoisé, Benoît; Colasse, Sabrina; Burlet, Philippe; Viollet, Louis; Meier, U Thomas; Lefebvre, Suzie

    2009-04-01

    Spinal muscular atrophy (SMA) is a common autosomal recessive neurodegenerative disease caused by reduced survival motor neuron (SMN) levels. The assembly machinery containing SMN is implicated in the biogenesis of the spliceosomal small nuclear ribonucleoproteins (snRNPs). SMN is present in both the cytoplasm and nucleus, where it transiently accumulates in subnuclear domains named Cajal bodies (CBs) and functions in the maturation of snRNPs and small nucleolar (sno)RNPs. The impact of lowering SMN levels on the composition of CBs in SMA cells is still not completely understood. Here, we analyse the CB composition in immortalized and primary fibroblasts from SMA patients. We show that the U snRNA export factors PHAX and chromosome region maintenance 1 and the box C/D snoRNP core protein fibrillarin concentrate in CBs from SMA cells, whereas the box H/ACA core proteins GAR1 and NAP57/dyskerin show reduced CB localization. Remarkably, the functional deficiency in SMA cells is associated with decreased localization of the snoRNP chaperone Nopp140 in CBs that correlates with disease severity. Indeed, RNA interference knockdown experiments in control fibroblasts demonstrate that SMN is required for accumulation of Nopp140 in CBs. Conversely, overexpression of SMN in SMA cells restores the CB localization of Nopp140, whereas SMN mutants found in SMA patients are defective in promoting the association of Nopp140 with CBs. Taken together, we demonstrate that only a subset of CB functions (as indicated by the association of representative factors) are impaired in SMA cells and, importantly, we identify the decrease of Nopp140 localization in CBs as a phenotypic marker for SMA.

  3. Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature.

    Science.gov (United States)

    Giuggioli, Dilia; Colaci, M; Cassone, G; Fallahi, P; Lumetti, F; Spinella, A; Campomori, F; Manfredi, A; Manzini, C U; Antonelli, A; Ferri, C

    2017-03-01

    Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease's features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (D levels (D deficiency persisted in 12/49 (24.5%) individuals. Parathormone levels inversely correlated with 25-OH-vitD (r = -0.3, p D was statistically associated with autoimmune thyroiditis (p = 0.008), while calcinosis was more frequently observed in patients of group A (p = 0.057). Moreover, we found significantly higher percentage of serum anticentromere antibodies in group B patients with 25-OH-vitD level ≥30 ng/ml (8/15 vs. 6/34; p = 0.017). In literature, hypovitaminosis D is very frequent in SSc patients. An association with disease duration, calcinosis, or severity of pulmonary involvement was occasionally recognized. Hypovitaminosis D is very frequent in SSc and severe in a relevant percentage of patients; furthermore, less than one third of supplemented subjects reached normal levels of 25-OH-vitD. The evaluation of 25-OH-vitD levels should be included in the routine clinical work-up of SSc. The above findings expand previous observations and may stimulate further investigations.

  4. Chemical and Isotopic Variations with Depth: a Detailed Saturated Zone Profile of a 140m Thick Coastal Aquifer

    Science.gov (United States)

    Raanan, H.; Ronen, D.; Weisbrod, N.; Dahan, O.; Seiler, K.; Vengosh, A.

    2005-12-01

    A percussion borehole was constructed through the saturated zone of the Mediterranean coastal aquifer in Tel Aviv, Israel, penetrating its three subaquifers and the upper part of the underlying Saqiye aquitard. The research site was previously subjected to direct industrial contamination and is currently exposed to the industrial contaminants in the outskirts of the densely populated Tel Aviv metropolis. Here we report the results of a large variety of analysis conducted on the 140m saturated profile that included field measurements (e.g. dissolved oxygen, pH, temperature, conductivity), major elements (e.g. Cl-, SO42-, HCO3-, NO3-, Ca2+, K+, Na+), trace elements (e.g. Pb, Fe, Cu) and radium isotopic measurements (223Ra, 224Ra, 226Ra). A clear distinction between the units becomes evident along the vertical profile; the upper phreatic unit (A) appears to be more saline relative to the central unit (B) (TDS of 734 and 670 mg/L, respectively). The deep unit (C) is significantly more saline in its lower part (up to 860 mg/L). We observed two nitrate peaks in the central zones of subaquifers B and C. The high nitrate peaks are associated with low Na/Cl and high Ca/Cl ratios. The 224Ra/223Ra ratio also changes with depth; in the upper and the lower subaquifers the relatively low 224Ra/223Ra ratios (50) indicates a larger fraction of a uranium source whereas in the central zone of the aquifer high 224Ra/223Ra ratios reflect rather a predominant thorium source for the dissolved radium. The data obtained through this borehole allows a rare investigation of the heterogeneity of water quality and composition in a coastal aquifer. The data provides characterization of different end-members along the saturated zone and also indicates the different proportions of lateral versus vertical flows of groundwater in a porous media.

  5. Incidence of malignant skin tumors in 14,140 patients after grenz-ray treatment for benign skin disorders

    Energy Technology Data Exchange (ETDEWEB)

    Lindeloef, B.E.; Eklund, G.

    1986-12-01

    During the years 1949 to 1975, 14,237 patients received therapeutic doses of grenz rays for the treatment of benign skin disorders such as chronic eczema, psoriasis, and warts. The records of 14,140 of these patients (99.3%) formed the basis for an epidemiologic study of the incidence of skin malignancies in this population. Information about the patients, diagnoses, doses, and sites of treatment was obtained from separate records. The follow-up time was 15 years on the average. We searched the Swedish Cancer Registry, Stockholm, for records reporting the incidence of malignant skin tumors in the study population (incidences of basal cell carcinoma are not registered). The expected number of malignancies was calculated on the basis of age- and sex-standardized incidence data from the Swedish Cancer Registry. In 58 patients, a malignant skin tumor was diagnosed more than five years after grenz-ray therapy had first been administered. Nineteen patients had malignant melanomas, and 39 patients had other malignant skin tumors. The expected number of melanomas was 17.8, and that of other malignant skin tumors was 26.9. None of the patients with melanomas, and only eight of the patients with other malignant skin tumors, had received grenz-ray therapy at the site of the tumor. Six of these eight patients had also been exposed to other known carcinogens. Four hundred eighty-one patients had received an accumulated high dose of grenz rays (greater than or equal to 10 000 rad (greater than or equal to 100 Gy)) on one and the same area. No malignancies were found on those areas. Although we cannot exclude grenz-ray therapy as a risk factor in the development of nonmelanoma skin malignancies, this risk, if any, is small, if recommendations for therapy are followed.

  6. Clinical observation of early intravenous injection with metoprolol in 140 patients with acute myocardial infarction%早期静注倍他乐克治疗急性心肌梗死140例临床观察

    Institute of Scientific and Technical Information of China (English)

    齐新颜; 李金龙; 张小丽; 王磊

    2006-01-01

    目的 观察早期静注倍他乐克治疗急性心肌梗死(AMI)的临床疗效.方法 对已确诊的140例急性心肌梗死患者,按照倍他乐克的使用情况,随机分为试验组和对照组.两组入选后均常规给予尿激酶(uk)150万u静脉溶栓,低分子肝素(LMWH)、阿司匹林、硝酸甘油等综合治疗,其中两组均有30例行经皮冠状动脉介入干预(PCI)治疗.试验组入院后尽快给予静脉注射倍他乐克5mg(1mg/min),共3次,每次间隔5 min,观察血压、心率的变化,总量15 mg.静脉注射完成15min后,开始口服普通倍他乐克每6 h 1次,每次12.5~25 mg,连续1个月.对照组入院后给予口服倍他乐克12.5~25 mg每8 h 1次,逐渐加量最大50 mg/次.对两组疗效进行对照分析.结果 试验组较对照组室性心律失常、室颤、心衰、再梗死率、ST段抬高持续天数、病死率的发生均显著下降(P<0.01).低血压、房室传导阻滞(A-VB)等并发症的发生率差异无显著性(P>0.05).结论 早期静注倍他乐克可改善急性心肌梗死的预后.

  7. Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

    Science.gov (United States)

    Tao, Shi-Cong; Yuan, Ting; Zhang, Yue-Lei; Yin, Wen-Jing; Guo, Shang-Chun; Zhang, Chang-Qing

    2017-01-01

    OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world. Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells (SMSC-140s) may be effective in treating OA. We hypothesized that exosomes derived from SMSC-140 (SMSC-140-Exos) would enhance the proliferation and migration abilities of articular chondrocytes (ACs) without harming extracellular matrix (ECM) secretion. METHODS: SMSCs were transfected with or without miR-140-5p. Exosomes derived from SMSCs or SMSC-140s (SMSC-Exos or SMSC-140-Exos) were isolated and identified. Proliferation, migration and ECM secretion were measured in vitro and compared between groups. The mechanism involving alternative Wnt signalling and activation of Yes-associated protein (YAP) was investigated using lentivirus, oligonucleotides or chemical drugs. The preventative effect of exosomes in vivo was measured using Safranin-O and Fast green staining and immunohistochemical staining. RESULTS: Wnt5a and Wnt5b carried by exosomes activated YAP via the alternative Wnt signalling pathway and enhanced proliferation and migration of chondrocytes with the side-effect of significantly decreasing ECM secretion. Highly-expressed miR-140-5p blocked this side-effect via RalA. SMSC-140-Exos enhanced the proliferation and migration of ACs without damaging ECM secretion in vitro, while in vivo, SMSC-140-Exos successfully prevented OA in a rat model. CONCLUSIONS: These findings highlight the promising potential of SMSC-140-Exos in preventing OA. We first found a potential source of exosomes and studied their merits and shortcomings. Based on our understanding of the molecular mechanism, we overcame the shortcomings by modifying the exosomes. Such exosomes derived from modified cells hold potential as future therapeutic strategies. PMID:28042326

  8. Changes of Heart Function of 140 Cases with Ankylosing Spondylitis and Relative Analysis%140例强直性脊柱炎患者的心功能变化及相关性分析

    Institute of Scientific and Technical Information of China (English)

    齐亚军; 刘健; 曹云祥; 孙口; 王芳; 叶文芳

    2013-01-01

    Objective:To study the changes of heart function of patients with ankylosing spondylitis and analyze their correlativity with other indexes.Methods:Changes of heart function of 140 cases with ankylosing spondylitis were detected by ultrasonic cardiogram(UCG)and compared with those of 30 cases in the normal control group,observing their clinical symptoms,signs,laboratory indexes and their correlativity with parameters of cardiac function and exploring the mechanism.Results:①The abnormal rate of the ankylosing spondylitis group was 33.56% by UCG,while that of the normal control group was 9.99%,the difference being statistically signiifcant (P<0.01).②The blood stream peak of the late diastole(peak A)in the patients with ankylosing spondylitis increased signiifcantly(P<0.01);the blood stream peak of the early diastole(peak E),the ejection fraction(EF) and the ratio of E/A decreased signiifcantly (P<0.01). ③ The Spearman correlation analysis showed that there were positive correlations respectively between the heart function parameter peak E and interleukin-10,and between peak A and palpitations (P < 0.05 or P < 0.01).There were negative correlations respectively between peak E and duration of disease,loss of appetite,few words due to deficiency of qi,abdominal distention after eating,loose stool,blood platelet count,uric acid,immunoglobulin G,erythrocyte sedimentation rate and C-reactive protein,between E/A ratio and the course of disease,loss of appetite,few words due to deifciency of qi,abdominal distention after eating,loose stool,a-acidoglycoprotein and interleukin-17,between ejection fraction(EF)and the course,palpitations,fatigue,a bdominal distention after eating,C3,and between FS and few words due to deifciency of qi and triglyceride(P<0.05 or P<0.01).Conclusion:The cardiac function of patients with ankylosing spondylitis decreased,manifesting on the aspects of the increase of peak A and the decrease of peak E,ejection fraction(EF)and the ratio of E

  9. Expression and Regulatory Network Analysis of miR-140-3p, a New Potential Serum Biomarker for Autism Spectrum Disorder

    Directory of Open Access Journals (Sweden)

    Matilde Cirnigliaro

    2017-08-01

    Full Text Available Given its prevalence and social impact, Autism Spectrum Disorder (ASD is drawing much interest. Molecular basis of ASD is heterogeneous and only partially known. Many factors, including disorders comorbid with ASD, like TS (Tourette Syndrome, complicate ASD behavior-based diagnosis and make it vulnerable to bias. To further investigate ASD etiology and to identify potential biomarkers to support its precise diagnosis, we used TaqMan Low Density Array technology to profile serum miRNAs from ASD, TS, and TS+ASD patients, and unaffected controls (NCs. Through validation assays in 30 ASD, 24 TS, and 25 TS+ASD patients and 25 NCs, we demonstrated that miR-140-3p is upregulated in ASD vs.: NC, TS, and TS+ASD (Tukey's test, p-values = 0.03, = 0.01, < 0.0001, respectively. ΔCt values for miR-140-3p and YGTSS (Yale Global Tic Severity Scale scores are positively correlated (Spearman r = 0.33; Benjamini-Hochberg p = 0.008 and show a linear relationship (p = 0.002. Network functional analysis showed that nodes controlled by miR-140-3p, especially CD38 and NRIP1 which are its validated targets, are involved in processes convergingly dysregulated in ASD, such as synaptic plasticity, immune response, and chromatin binding. Biomarker analysis proved that serum miR-140-3p can discriminate among: (1 ASD and NC (Area under the ROC curve, AUC: 0.70; sensitivity: 63.33%; specificity: 68%; (2 ASD and TS (AUC: 0.72; sensitivity: 66.66%; specificity: 70.83%; (3 ASD and TS+ASD (AUC: 0.78; sensitivity: 73.33%; specificity: 76%. Characterization of miR-140-3p network would contribute to further clarify ASD etiology. Serum miR-140-3p could represent a potential non-invasive biomarker for ASD, easy to test through liquid biopsy.

  10. Activated changes of platelet ultra microstructure and plasma granule membrane protein 140 in patients with non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    ZHUGE Yi; ZHOU Jian-ying; YANG Guang-die; ZU De-ling; XU Xiao-liang; TIAN Ming-qing; LU Guo-hua

    2009-01-01

    Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Platelet activation may play an important role in pathologic progress in lung cancer. In this study, we aimed to clarify the influence of activated platelets on lung cancer generation and growth, and the relationship among these functional and ultrastructural changes of platelets and the severity of pathogenetic condition in these patients with NSCLC.Methods One hundred and thirty-six cases of patients with pathologically confirmed NSCLC were included in this study. Fifty-four healthy people were enrolled as controls. The change of ultra microstructure and activity of blood platelets were observed under the transmission and scanning electron microscope. Simultaneous determination of plasma granule membrane protein 140 (GMP-140) was made.Results Transmission electron microscopy showed remarkable changes of ultra microstructure of platelets in patients with NSCLC, including swelling, increase of o-granules, vesicles, and glycogenosome. Scanning electron microscopy showed many more surface processes and wrinkles on platelets in patients with NSCLC. The reference plasma levels of GMP-140 of healthy controls were (18.2±2.7) μg/L. The plasma levels of GMP-140 in patients with NSCLC were (47.8±12.3) μg/L, which were much higher than those of the controls. There was a medium positive correlation between plasma levels of GMP-140 and amount of o-granules (r=0.514, P<0.01) and a high positive correlation between plasma levels of GMP-140 and area of platelet (r=0.84, P<0.01) in patients with NSCLC. The Kaplan-Meier survival curve analysis showed significant shift to the left in patients with NSCLC whose α-granules per platelet were 19 or more compared to those 18 or less (Log rank statistic, X2=17.38, P <0.01).Conclusions There are significant activated changes of ultra microstructure and increased activity of blood platelets in patients with NSCLC. These activated platelets

  11. The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma.

    Science.gov (United States)

    Peled, Amnon; Abraham, Michal; Avivi, Irit; Rowe, Jacob M; Beider, Katia; Wald, Hanna; Tiomkin, Lena; Ribakovsky, Lena; Riback, Yossi; Ramati, Yaron; Aviel, Sigal; Galun, Eithan; Shaw, Howard Laurence; Eizenberg, Orly; Hardan, Izhar; Shimoni, Avichai; Nagler, Arnon

    2014-01-15

    CXCR4 plays an important role in the retention of stem cells within the bone marrow. BKT140 (4F-benzoyl-TN14003) is a 14-residue bio stable synthetic peptide, which binds CXCR4 with a greater affinity compared with plerixafor (4 vs. 84 nmol/L). Studies in mice demonstrated the efficient and superior mobilization and transplantation of stem cells collected with GCSF-BKT140, compared with those obtained when using stem cells obtained with each one of these mobilizing agent alone. These results have served as a platform for the present clinical phase I study. Eighteen patients with multiple myeloma who were preparing for their first autologous stem cell transplantation were included. Patients received a standard multiple myeloma mobilization regimen, consisting of 3 to 4 g/m(2) cyclophosphamide (day 0), followed by granulocyte colony-stimulating factor (G-CSF) at 5 μg/kg/d starting on day 5 and administered between 8 and 10 pm until the end of stem cell collection. A single injection of BKT140 (0.006, 0.03, 0.1, 0.3, and 0.9 mg/kg) was administered subcutaneously on day 10 in the early morning, followed by G-CSF 12 hours later. BKT140 was well tolerated at all concentrations, and none of the patients developed grade 3 and 4 toxicity. A single administration of BKT140 at the highest dose, 0.9 mg/kg, resulted in a robust mobilization and collection of CD34(+) cells (20.6 ± 6.9 × 10(6)/kg), which were obtained through a single apheresis. All transplanted patients received ∼5.3 × 10(6) CD34(+) cells/kg, which rapidly engrafted (n = 17). The median time to neutrophil and platelet recovery was 12 and 14 days, respectively, at the highest dose (0.9 mg/kg). When combined with G-CSF, BKT140 is a safe and efficient stem cell mobilizer that enabled the collection of a high number of CD34(+) cells in 1 and 2 aphaeresis procedures, resulting in successful engraftment. ©2013 AACR.

  12. A PROSPECTIVE OBSERVATIONAL STUDY REGARDING PREVALENCE OF DRY EYE DISEASE IN POST-OPERATIVE CATARACT SURGERY PATIENTS OF 140 CASES.

    Directory of Open Access Journals (Sweden)

    S. Srinivasan

    2017-02-01

    Full Text Available BACKGROUND Dry eye disease is one of the most common ocular surface disorder with large number of studies carried out in various countries estimate the prevalence of dry eye disease to be between 5-34%. The prevalence of dry eye increases with age. As per Breaver Dam study regarding dry eye the prevalence of DED 13.3%. Dry eye was apparently higher in women than men. Studies have shown that cataract surgery worsen dry eye symptoms in patients with preexisting dry eye symptoms as well as without preexisting DES, mostly dry eye symptoms last for two months of post cataract surgery period. MATERIALS AND METHODS The prospective observational study was conducted in Department of Ophthalmology, Government Vellore Medical College and Hospital, Vellore. The total number of cataract surgery performed cases were 140 in number. The study period was four months, conducted in tertiary eye center. The Cataract patients were preoperatively at normal tear secretions. Post cataract surgery period from first POD, one week POD, four weeks, six weeks, two months and three months POD examined by slit lamp, Schirmer's test I, TBUT and corneal sensitivity test were performed. RESULTS Our study revealed that increased prevalence in female sex with increased age group range from 51-70 years showed post cataract surgery period dryness of eye. The ratio of Post cataract surgery DED in male and female is 13:29. This shows increased female sex prevalence of postoperative DED. In our study, the prevalence of post cataract surgery dry eye disease was 30%. CONCLUSION 73% cataract surgeries is now clear corneal cataract surgery and this procedure cuts a large part of corneal nerves. The nerve essential for tear production gets disturbed leading to dryness and hence decreased visual function. The corneal nerves are important in self-regulation of tears since they provide the sensation in the feedback loop that signals tear production. When the functions of the nerves get blocked

  13. Growth hormone and prolactin responses to bolus and sustained infusions of GRH-1-40-OH in man.

    Science.gov (United States)

    Goldman, J A; Molitch, M E; Thorner, M O; Vale, W; Rivier, J; Reichlin, S

    1987-08-01

    To determine whether GRH stimulates PRL secretion we studied the effects of iv bolus injections and prolonged infusions of GRH 1-40-OH on PRL and GH serum levels in normal volunteers. Eight patients with acromegaly, two of whom had elevated basal levels of PRL, were also tested with single bolus injections. Six normal subjects given 3.3 micrograms/kg bolus injections of GRH showed a mean increment of GH of 22.0 +/- 1.7 ng/ml (mean +/- SE). A small rise in PRL was noted in 5 of the 6 subjects (mean peak level of 6.4 +/- 1.9 ng/ml vs basal level of 3.3 +/- 0.4 ng/ml, p less than 0.05). During the continuous intusion of GRH (10 ng/kg/min), GH levels rose gradually from a mean baseline of 1.1 +/- 0.1 ng/ml to a mean peak of 30.0 +/- 7.2 ng/ml at about 2 h and then slowly declined to a nadir of 4.2 +/- 0.4 ng/ml at 330 min. PRL levels did not rise significantly during the infusion. To determine whether the decline in GH levels in the face of continued infusion was due to loss of GH responsiveness, a 3.3 micrograms/kg bolus of GRH was given during the nadir at 330 min; this GH increment was significantly less than that obtained by the GRH bolus injection without the infusion (12.9 +/- 3.5 ng/ml vs 22.0 +/- 1.7 ng/ml, p less than 0.05). The PRL response to the GRH bolus was the same during the infusion of GRH as before. In each of 8 acromegalic patients (including two who had initially elevated basal PRL levels) GRH led to an increase in both GH and PRL levels. PRL and GH levels spontaneously fluctuated in parallel in 4 acromegalic cases studied with repeated samples over 6 h during placebo administration. These experiments show that GRH has significant, though weak, PRF effect in normals and that it is more potent PRF in acromegalic patients. Furthermore, the effects on GH and PRL of a sustained infusion of GRH for 5 1/2 h are both qualitatively and quantitatively different. These results suggest that the GRH effect is exerted either on different pituitary receptors for

  14. Excitation of the helium autoionizing states in He/sup +/+He collisions, between 3 and 140 keV

    Energy Technology Data Exchange (ETDEWEB)

    Bordenave-Montesquieu, A.; Gleizes, A.; Benoit-Cattin, P.

    1982-01-01

    The autoionization of the helium atom has been experimentally studied in He/sup +/+He collisions between 3 and 140 keV by electron spectrometry. The excitation of the two collision partners has been considered. Above 10 keV, the shapes and excitation cross sections of the 2s/sup 2/ /sup 1/S, 2s2p /sup 3/P, 2p/sup 2/ /sup 1/D, and 2s2p /sup 1/P are determined by a numerical fitting procedure which is reported in detail; below 10 keV the (/sup 1/D+/sup 1/P), and 2p/sup 2/ /sup 1/S line intensities are obtained by planimetry since important post-collision effects are observed. From the angular distributions measured below 15 keV, the relative sublevel populations are deduced for the 2p/sup 2/ /sup 1/D and 2s2p/sup 1/ P levels and are compared with those obtained by other authors in a coincidence experiment; the excitation processes are then discussed within the quasimolecular-excitation model. For the highest collision energies, the asymmetry of the angular distributions with respect to 90 /sup 0/ as well as the line shapes above 100 keV are interpreted by the occurrence of sudden electronic transitions to the continuum. A comparison of the differential cross sections for emission of electrons by autoionization of the fast and slow particles permits us to show that the quasimolecule model cannot explain what is observed above a collision velocity of about 0.5 a.u. The dependence of the total cross sections against the collision energy is also discussed in terms of an evolution of the excitation mechanism from a quasimolecular to an atomic one; the specific variation of the 2s2p /sup 3/P cross section strengthens this interpretation. These total cross sections are compared with those estimated from earlier H/sup +/+He data published by us; similar autoionization cross-section values are expected for the two systems at high collision velocity.

  15. Transient-field g-factor measurement of the first 2 sup + states in the N=82 nuclei sup 140 Ce, sup 142 Nd and sup 144 Sm

    Energy Technology Data Exchange (ETDEWEB)

    Bazzacco, D.; Brandolini, F.; Loewenich, K.; Pavan, P.; Rossi-Alvarez, C.; Maglione, E. (Dipt. di Fisica, Padua Univ. (Italy) Ist. Nazionale di Fisica Nucleare, Padua (Italy)); De Poli, M.; Haque, A.M.I. (Ist. Nazionale di Fisica Nucleare, Lab. Nazionale di Legnaro (Italy))

    1991-10-28

    The g-factor of the first 2{sup +} states in three stable N=82 nuclei, {sup 140}Ce, {sup 142}Nd and {sup 144}Sm, have been measured using the transient magnetic field technique. The levels under study were Coulomb excited with 110-116 MeV {sup 32}S beams and spin precession after passing a thin polarized iron foil was measured. The field strength has been checked using the first 2{sup +} state in {sup 148}Sm as internal calibration. The obtained values were 0.97(9), 0.84(7), 0.76(11) for {sup 140}Ce, {sup 142}Nd and {sup 144}Sm, respectively. These remarkably lower values with respect to shell-model predictions in a proton subspace are explained in terms of neutron core excitation by quasiparticle random-phase-approximation calculations. (orig.).

  16. Corrective Action Decision Document for Corrective Action Unit 140: Waste Dumps, Burn Pits, and Storage Area, Nevada Test Site, Nevada: Revision No. 0

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-10-17

    This Corrective Action Decision Document identifies and rationalizes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's selection of a recommended corrective action alternative appropriate to facilitate the closure of Corrective Action Unit (CAU) 140: Waste Dumps, Burn Pits, and Storage Area, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. Located in Areas 5, 22, and 23 of the NTS, CAU 140 consists of nine corrective action sites (CASs). Investigation activities were performed from November 13 through December 11, 2002, with additional sampling to delineate the extent of contaminants of concern (COCs) conducted on February 4 and March 18 and 19, 2003. Results obtained from the investigation activities and sampling indicated that only 3 of the 9 CASs at CAU 140 had COCs identified. Following a review of existing data, future land use, and current operations at the NTS, the following preferred alternatives were developed for consideration: (1) No Further Action - six CASs (05-08-02, 05-17-01, 05-19-01, 05-35-01, 05-99-04, and 22-99-04); (2) Clean Closure - one CAS (05-08-01), and (3) Closure-in-Place - two CASs (05-23-01 and 23-17-01). These alternatives were judged to meet all requirements for the technical components evaluated. Additionally, the alternatives meet all applicable state and federal regulations for closure of the site and will eliminate potential future exposure pathways to the contaminated media at CAU 140.

  17. Measurement of hadron and lepton-pair production at 130 GeV < √s < 140 GeV at LEP

    Science.gov (United States)

    Acciarri, M.; Adam, A.; Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.; Alpat, B.; Alcaraz, J.; Allaby, J.; Aloisio, A.; Alverson, G.; Alviggi, M. G.; Ambrosi, G.; Anderhub, H.; Andreev, V. P.; Angelescu, T.; Antreasyan, D.; Arefiev, A.; Azemoon, T.; Aziz, T.; Bagnaia, P.; Baksay, L.; Ball, R. C.; Banerjee, S.; Banicz, K.; Barillère, R.; Barone, L.; Bartalini, P.; Baschirotto, A.; Basile, M.; Battiston, R.; Bay, A.; Becattini, F.; Becker, U.; Behner, F.; Bencze, Gy. L.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B. L.; Biasini, M.; Biland, A.; Bilei, G. M.; Blaising, J. J.; Blyth, S. C.; Bobbink, G. J.; Bock, R.; Böhm, A.; Borgia, B.; Boucham, A.; Bourilkov, D.; Bourquin, M.; Boutigny, D.; Brambilla, E.; Branson, J. G.; Brigljevic, V.; Brock, I. C.; Buijs, A.; Bujak, A.; Burger, J. D.; Burger, W. J.; Burgos, C.; Busenitz, J.; Buytenhuijs, A.; Cai, X. D.; Campanelli, M.; Capell, M.; Cara Romeo, G.; Caria, M.; Carlino, G.; Cartacci, A. M.; Casaus, J.; Castellini, G.; Castello, R.; Cavallari, F.; Cavallo, N.; Cecchi, C.; Cerrada, M.; Cesaroni, F.; Chamizo, M.; Chan, A.; Chang, Y. H.; Chaturvedi, U. K.; Chemarin, M.; Chen, A.; Chen, C.; Chen, G.; Chen, G. M.; Chen, H. F.; Chen, H. S.; Chereau, X.; Chiefari, G.; Chien, C. Y.; Choi, M. T.; Cifarelli, L.; Cindolo, F.; Civinini, C.; Clare, I.; Clare, R.; Coan, T. E.; Cohn, H. O.; Coignet, G.; Colijn, A. P.; Colino, N.; Commichau, V.; Costantini, S.; Cotorobai, F.; de la Cruz, B.; Dai, T. S.; D'Alessandro, R.; de Asmundis, R.; De Boeck, H.; Degré, A.; Deiters, K.; Dénes, E.; Denes, P.; DeNotaristefani, F.; DiBitonto, D.; Diemoz, M.; van Dierendonck, D.; Di Lodovico, F.; Dionisi, C.; Dittmar, M.; Dominguez, A.; Doria, A.; Dorne, I.; Dova, M. T.; Drago, E.; Duchesneau, D.; Duinker, P.; Duran, I.; Dutta, S.; Easo, S.; Efremenko, Yu.; El Mamouni, H.; Engler, A.; Eppling, F. J.; Erné, F. C.; Ernenwein, J. P.; Extermann, P.; Fabbretti, R.; Fabre, M.; Faccini, R.; Falciano, S.; Favara, A.; Fay, J.; Felcini, M.; Ferguson, T.; Fernandez, D.; Fernandez, G.; Ferroni, F.; Fesefeldt, H.; Fiandrini, E.; Field, J. H.; Filthaut, F.; Fisher, P. H.; Forconi, G.; Fredj, L.; Freudenreich, K.; Gailloud, M.; Galaktionov, Yu.; Ganguli, S. N.; Garcia-Abia, P.; Gau, S. S.; Gentile, S.; Gerald, S.; Gheordanescu, N.; Giagu, S.; Goldfarb, S.; Goldstein, J.; Gong, Z. F.; Gonzalez, E.; Gougas, A.; Goujon, D.; Gratta, G.; Gruenewald, M. W.; Gupta, V. K.; Gurtu, A.; Gustafson, H. R.; Gutay, L. J.; Hangarter, K.; Hartmann, B.; Hasan, A.; He, J. T.; Hebbeker, T.; Hervé, A.; van Hoek, W. C.; Hofer, H.; Hoorani, H.; Hou, S. R.; Hu, G.; Ilyas, M. M.; Innocente, V.; Janssen, H.; Jin, B. N.; Jones, L. W.; de Jong, P.; Josa-Mutuberria, I.; Kasser, A.; Khan, R. A.; Kamyshkov, Yu.; Kapinos, P.; Kapustinsky, J. S.; Karyotakis, Y.; Kaur, M.; Kienzle-Focacci, M. N.; Kim, D.; Kim, J. K.; Kim, S. C.; Kim, Y. G.; Kinnison, W. W.; Kirkby, A.; Kirkby, D.; Kirkby, J.; Kittel, W.; Klimentov, A.; König, A. C.; Koffeman, E.; Köngeter, A.; Koutsenko, V.; Koulbardis, A.; Kraemer, R. W.; Kramer, T.; Krenz, W.; Kuijten, H.; Kunin, A.; Ladron de Guevara, P.; Landi, G.; Lapoint, C.; Lassila-Perini, K.; Laurikainen, P.; Lebeau, M.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, J. S.; Lee, K. Y.; Leggett, C.; Le Goff, J. M.; Leiste, R.; Lenti, M.; Leonardi, E.; Levtchenko, P.; Li, C.; Lieb, E.; Lin, W. T.; Linde, F. L.; Lindemann, B.; Lista, L.; Liu, Z. A.; Lohmann, W.; Longo, E.; Lu, W.; Lu, Y. S.; Lübelsmeyer, K.; Luci, C.; Luckey, D.; Ludovici, L.; Luminari, L.; Lustermann, W.; Ma, W. G.; Macchiolo, A.; Maity, M.; Majumder, G.; Malgeri, L.; Malinin, A.; Maña, C.; Mangla, S.; Maolinbay, M.; Marchesini, P.; Marin, A.; Martin, J. P.; Marzano, F.; Massaro, G. G. G.; Mazumdar, K.; McNally, D.; McNeil, R. R.; Mele, S.; Merola, L.; Meschini, M.; Metzger, W. J.; von der Mey, M.; Mi, Y.; Mihul, A.; van Mil, A. J. W.; Mirabelli, G.; Mnich, J.; Möller, M.; Monteleoni, B.; Moore, R.; Morganti, S.; Mount, R.; Müller, S.; Muheim, F.; Nagy, E.; Nahn, S.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Nippe, A.; Nowak, H.; Organtini, G.; Ostonen, R.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Park, H. K.; Pascale, G.; Passaleva, G.; Patricelli, S.; Paul, T.; Pauluzzi, M.; Paus, C.; Pauss, F.; Pei, Y. J.; Pensotti, S.; Perret-Gallix, D.; Petrak, S.; Pevsner, A.; Piccolo, D.; Pieri, M.; Pinto, J. C.; Piroué, P. A.; Pistolesi, E.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Produit, N.; Raghavan, R.; Rahal-Callot, G.; Rancoita, P. G.; Rattaggi, M.; Raven, G.; Razis, P.; Read, K.; Redaelli, M.; Ren, D.; Rescigno, M.; Reucroft, S.; Ricker, A.; Riemann, S.; Riemers, B. C.; Riles, K.; Rind, O.; Ro, S.; Robohm, A.; Rodin, J.; Rodriguez, F. J.; Roe, B. P.; Röhner, S.; Romero, L.; Rosier-Lees, S.; Rosselet, Ph.; van Rossum, W.; Roth, S.; Rubio, J. A.; Rykaczewski, H.; Salicio, J.; Salicio, J. M.; Sanchez, E.; Santocchia, A.; Sarakinos, M. E.; Sarkar, S.; Sassowsky, M.; Schäfer, C.; Schegelsky, V.; Schmidt-Kaerst, S.; Schmitz, D.; Schmitz, P.; Schneegans, M.; Schoeneich, B.; Scholz, N.; Schopper, H.; Schotanus, D. J.; Schulte, R.; Schultze, K.; Schwenke, J.; Schwering, G.; Sciacca, C.; Seiler, P. G.; Sens, J. C.; Servoli, L.; Shevchenko, S.; Shivarov, N.; Shoutko, V.; Shukla, J.; Shumilov, E.; Siedenburg, T.; Son, D.; Sopczak, A.; Soulimov, V.; Smith, B.; Spillantini, P.; Steuer, M.; Stickland, D. P.; Sticozzi, F.; Stone, H.; Stoyanov, B.; Straessner, A.; Strauch, K.; Sudhakar, K.; Sultanov, G.; Sun, L. Z.; Susinno, G. F.; Suter, H.; Swain, J. D.; Tang, X. W.; Tauscher, L.; Taylor, L.; Ting, Samuel C. C.; Ting, S. M.; Toker, O.; Tonisch, F.; Tonutti, M.; Tonwar, S. C.; Tóth, J.; Tsaregorodtsev, A.; Tully, C.; Tuchscherer, H.; Tung, K. L.; Ulbricht, J.; Urbán, L.; Uwer, U.; Valente, E.; Van de Walle, R. T.; Vetlitsky, I.; Viertel, G.; Vivargent, M.; Völkert, R.; Vogel, H.; Vogt, H.; Vorobiev, I.; Vorobyov, A. A.; Vorobyov, An. A.; Vuilleumier, L.; Wadhwa, M.; Wallraff, W.; Wang, J. C.; Wang, X. L.; Wang, Y. F.; Wang, Z. M.; Weber, A.; Weill, R.; Willmott, C.; Wittgenstein, F.; Wu, S. X.; Wynhoff, S.; Xu, J.; Xu, Z. Z.; Yang, B. Z.; Yang, C. G.; Yao, X. Y.; Ye, J. B.; Yeh, S. C.; You, J. M.; Zaccardelli, C.; Zalite, An.; Zemp, P.; Zeng, J. Y.; Zeng, Y.; Zhang, Z.; Zhang, Z. P.; Zhou, B.; Zhou, G. J.; Zhou, Y.; Zhu, G. Y.; Zhu, R. Y.; Zichichi, A.; van der Zwaan, B. C. C.; L3 Collaboration

    1996-02-01

    We report on the first measurements of e +e - annihilations into hadrons and lepton pairs at centre-of-mass energies between 130 GeV and 140 GeV. In a total luminosity of 5 pb -1 collected with the L3 detector at LEP we select 1577 hadronic and 401 lepton-pair events. The measured cross sections and leptonic forward-backward asymmetries agree well with the Standard Model predictions.

  18. Injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew.

    Science.gov (United States)

    Lin, Na; Xiong, Liu-Lin; Zhang, Rong-Ping; Zheng, Hong; Wang, Lei; Qian, Zhong-Yi; Zhang, Piao; Chen, Zhi-Wei; Gao, Fa-Bao; Wang, Ting-Hua

    2016-05-01

    Alzheimer's disease (AD) can incur significant health care costs to the patient, their families, and society; furthermore, effective treatments are limited, as the mechanisms of AD are not fully understood. This study utilized twelve adult male tree shrews (TS), which were randomly divided into PBS and amyloidbetapeptide1-40 (Aβ1-40) groups. AD model was established via an intracerebroventricular (icv) injection of Aβ1-40 after being incubated for 4 days at 37 °C. Behavioral, pathophysiological and molecular changes were evaluated by hippocampal-dependent tasks, magnetic resonance imaging (MRI), silver staining, hematoxylin-eosin (HE) staining, TUNEL assay and gene sequencing, respectively. At 4 weeks post-injection, as compared with the PBS group, in Aβ1-40 injected animals: cognitive impairments happened, and the hippocampus had atrophied indicated by MRI findings; meanwhile, HE staining showed the cells of the CA3 and DG were significantly thinner and smaller. The average number of cells in the DG, but not the CA3, was also significantly reduced; furthermore, silver staining revealed neurotic plaques and neurofibrillary tangles (NFTs) in the hippocampi; TUNEL assay showed many cells exhibited apoptosis, which was associated with downregulated BCL-2/BCL-XL-associated death promoter (Bad), inhibitor of apoptosis protein (IAP), Cytochrome c (CytC) and upregulated tumor necrosis factor receptor 1 (TNF-R1); lastly, gene sequencing reported a total of 924 mobilized genes, among which 13 of the downregulated and 19 of the upregulated genes were common to the AD pathway. The present study not only established AD models in TS, but also reported on the underlying mechanism involved in neuronal apoptosis associated with multiple gene expression.

  19. Measurement of hadron and lepton-pair production at 130 GeV $<$ $\\sqrt{s}$ $<$ 140 GeV at LEP

    CERN Document Server

    Acciarri, M; Adriani, O; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bencze, G L; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Bujak, A T; Burger, J D; Burger, W J; Burgos, C; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, C; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chéreau, X J; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coan, T E; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Commichau, V; Costantini, S; Cotorobai, F; de la Cruz, B; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Dénes, E; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabbretti, R; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Felcini, Marta; Ferguson, T; Fernández, D; Fernández, G; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Gailloud, M; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; González, E; Gougas, Andreas; Goujon, D; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gustafson, H R; Gutay, L J; Hangarter, K; Hartmann, B; Hasan, A; He, J T; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Koffeman, E; Köngeter, A; Koutsenko, V F; Koulbardis, A; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lindemann, B; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Maolinbay, M; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Möller, M; Monteleoni, B; Moore, R; Morganti, S; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Redaelli, M; Ren, D; Rescigno, M; Reucroft, S; Ricker, A; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Salicio, J M; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schulte, R; Schultze, K; Schwenke, J; Schwering, G; Sciacca, C; Seiler, P G; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Toker, O; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tsaregorodtsev, A Yu; Tully, C; Tuchscherer, H; Tung, K L; Ulbricht, J; Urbàn, L; Uwer, U; Valente, E; Van de Walle, R T; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vuilleumier, L; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Weill, R; Willmott, C; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zaccardelli, C; Zalite, A; Zemp, P; Zeng, J Y; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, G J; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino; Van der Zwaan, B C C

    1996-01-01

    We report on the first measurements of e+e- annihilations into hadrons and lepton pairs at center-of-mass energies between 130 GeV and 140 GeV. In a total luminosity of 5 pb-1 collected with the L3 detector at LEP we select 1577 hadronic and 401 lepton-pair events. The measured cross sections and leptonic forward-backward asymmetries agree well with the Standard Model predictions.

  20. Successful polymyxin B hemoperfusion treatment associated with serial reduction of serum anti-CADM-140/MDA5 antibody levels in rapidly progressive interstitial lung disease with amyopathic dermatomyositis.

    Science.gov (United States)

    Teruya, Aoi; Kawamura, Kodai; Ichikado, Kazuya; Sato, Shinji; Yasuda, Yuko; Yoshioka, Masakazu

    2013-12-01

    Clinically amyopathic dermatomyositis (CADM), a subtype of dermatomyositis with subtle or no muscle involvement, is occasionally accompanied by fatal, rapidly progressive interstitial lung disease (RP-ILD) that is resistant to aggressive immunosuppressive therapy. The presence of anti-CADM-140/MDA5 antibodies is diagnostic for patients with dermatomyositis (particularly CADM) and is known to be strongly associated with the pathogenesis, disease activity, and mortality of RP-ILD. Polymyxin-B direct hemoperfusion (PMX-DHP), originally developed for the removal of endotoxin, has been demonstrated to be effective for treating various types of acute respiratory failure. We describe a patient with amyopathic dermatomyositis who developed RP-ILD characterized by elevated anti-CADM-140/MDA5 autoantibodies, was resistant to combined steroid and immunosuppressant therapy, and was treated successfully with PMX-DHP. To our knowledge, this is the first case to indicate a serial reduction of anti-CADM-140/MDA5 autoantibodies, associated with clinical improvement, following PMX-DHP. Early intervention using PMX-DHP may improve the prognosis of RP-ILD accompanied by CADM.

  1. Similarity between the C18O (J=1-0) core mass function and the IMF in the S 140 region

    CERN Document Server

    Ikeda, Norio

    2011-01-01

    We present the results of C18O(J=1-0) mapping observations of a 20'x18' area in the Lynds 1204 molecular cloud associated with the Sharpless 2-140 (S140) H II region. The C18O cube (alpha-delta-vLSR) data shows that there are three clumps with sizes of \\sim 1 pc in the region. Two of them have peculiar red shifted velocity components at their edges, which can be interpreted as the results of the interaction between the cloud and the Cepheus Bubble. From the C18O cube data, the clumpfind identified 123 C18O cores, which have mean radius, velocity width in FWHM, and LTE mass of 0.36\\pm0.07 pc, 0.37\\pm0.09 km s-1, and 41\\pm29 Msun, respectively. All the cores in S140 are most likely to be gravitationally bound by considering the uncertainty in the C18O abundance. We derived a C18O core mass function (CMF), which shows a power-law-like behavior above a turnover at 30 Msun. The best-fit power-law index of -2.1\\pm0.2 is quite consistent with those of the IMF and the C18O CMF in the OMC-1 region by Ikeda & Kitam...

  2. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

    Science.gov (United States)

    Arias, Mauricio A; Van Roey, Griet A; Tregoning, John S; Moutaftsi, Magdalini; Coler, Rhea N; Windish, Hillarie P; Reed, Steven G; Carter, Darrick; Shattock, Robin J

    2012-01-01

    Successful vaccine development against HIV will likely require the induction of strong, long-lasting humoral and cellular immune responses in both the systemic and mucosal compartments. Based on the known immunological linkage between the upper-respiratory and urogenital tracts, we explored the potential of nasal adjuvants to boost immunization for the induction of vaginal and systemic immune responses to gp140. Mice were immunized intranasally with HIV gp140 together with micellar and emulsion formulations of a synthetic TLR4 agonist, Glucopyranosyl Lipid Adjuvant (GLA) and responses were compared to R848, a TLR7/8 agonist, or chitosan, a non TLR adjuvant. GLA and chitosan but not R848 greatly enhanced serum immunoglobulin levels when compared to antigen alone. Both GLA and chitosan induced high IgG and IgA titers in nasal and vaginal lavage and feces. The high IgA and IgG titers in vaginal lavage were associated with high numbers of gp140-specific antibody secreting cells in the genital tract. Whilst both GLA and chitosan induced T cell responses to immunization, GLA induced a stronger Th17 response and chitosan induced a more Th2 skewed response. Our results show that GLA is a highly potent intranasal adjuvant greatly enhancing humoral and cellular immune responses, both systemically and mucosally.

  3. Glucopyranosyl Lipid Adjuvant (GLA, a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

    Directory of Open Access Journals (Sweden)

    Mauricio A Arias

    Full Text Available Successful vaccine development against HIV will likely require the induction of strong, long-lasting humoral and cellular immune responses in both the systemic and mucosal compartments. Based on the known immunological linkage between the upper-respiratory and urogenital tracts, we explored the potential of nasal adjuvants to boost immunization for the induction of vaginal and systemic immune responses to gp140. Mice were immunized intranasally with HIV gp140 together with micellar and emulsion formulations of a synthetic TLR4 agonist, Glucopyranosyl Lipid Adjuvant (GLA and responses were compared to R848, a TLR7/8 agonist, or chitosan, a non TLR adjuvant. GLA and chitosan but not R848 greatly enhanced serum immunoglobulin levels when compared to antigen alone. Both GLA and chitosan induced high IgG and IgA titers in nasal and vaginal lavage and feces. The high IgA and IgG titers in vaginal lavage were associated with high numbers of gp140-specific antibody secreting cells in the genital tract. Whilst both GLA and chitosan induced T cell responses to immunization, GLA induced a stronger Th17 response and chitosan induced a more Th2 skewed response. Our results show that GLA is a highly potent intranasal adjuvant greatly enhancing humoral and cellular immune responses, both systemically and mucosally.

  4. Magnetocaloric and thermomagnetic properties of Ni2.18Mn0.82Ga Heusler alloy in high magnetic fields up to 140 kOe

    Science.gov (United States)

    Kamantsev, Alexander P.; Koledov, Victor V.; Mashirov, Alexey V.; Dilmieva, Elvina T.; Shavrov, Vladimir G.; Cwik, Jacek; Los, Anton S.; Nizhankovskii, Victor I.; Rogacki, Krzysztof; Tereshina, Irina S.; Koshkid'ko, Yuriy S.; Lyange, Maria V.; Khovaylo, Vladimir V.; Ari-Gur, Pnina

    2015-04-01

    Measurements of the adiabatic temperature change (ΔT) and the specific heat transfer (ΔQ) of Ni2.18Mn0.82Ga Heusler alloy were taken in order to quantify the direct giant magnetocaloric effect of the alloy when it is in the vicinity of magneto-structural phase transition (PT) from paramagnetic austenite to ferromagnetic martensite, and their results are presented. A new vacuum calorimeter was used to simultaneously measure ΔT and ΔQ of magnetocaloric materials with a Bitter coil magnet in fields of up to H = 140 kOe. Other thermomagnetic properties of this alloy were investigated using standard differential scanning calorimetry and PPMS equipment. The maximal values of magnetocaloric effect in H = 140 kOe were found to be ΔT = 8.4 K at initial temperature 340 K and ΔQ = 4900 J/kg at 343 K. Using this direct method, we show that the alloy indeed demonstrates the largest value of ΔQ as compared with previously published results for direct measurements of magnetocaloric materials, even though at 140 kOe the magnetic field-induced magnetostructural PT is still not complete.

  5. Initial stages of beta-amyloid Aβ1-40 and Aβ1-42 oligomerization observed using fluorescence decay and molecular dynamics analyses of tyrosine

    Science.gov (United States)

    Amaro, Mariana; Kubiak-Ossowska, Karina; Birch, David J. S.; Rolinski, Olaf J.

    2013-03-01

    The development of Alzheimer’s disease is associated with the aggregation of the beta-amyloid peptides Aβ1-40 and Aβ1-42. It is believed that the small oligomers formed during the early stages of the aggregation are neurotoxic and involved in the process of neurodegeneration. In this paper we use fluorescence decay measurements of beta-amyloid intrinsic fluorophore tyrosine (Tyr) and molecular dynamics (MD) simulations to study the early stages of oligomer formation for the Aβ1-40 and Aβ1-42 peptides in vitro. We demonstrate that the lifetime distributions of the amyloid fluorescence decay efficiently describe changes in the complex Tyr photophysics during the peptide aggregation and highlight the differences in aggregation performance of the two amyloids. Tyr fluorescence decay is found to be a more sensitive sensor of Aβ1-40 aggregation than Aβ1-42 aggregation. The MD simulation of the peptide aggregation is compared with the experimental data and supports a four-rotamer model of Tyr.

  6. Expanding phenotype of p.Ala140Val mutation in MECP2 in a 4 generation family with X-linked intellectual disability and spasticity.

    Science.gov (United States)

    Lambert, Sophie; Maystadt, Isabelle; Boulanger, Sébastien; Vrielynck, Pascal; Destrée, Anne; Lederer, Damien; Moortgat, Stéphanie

    2016-10-01

    Mutations in MECP2 (MIM #312750), located on Xq28 and encoding a methyl CpG binding protein, are classically associated with Rett syndrome in female patients, with a lethal effect in hemizygous males. However, MECP2 mutations have already been reported in surviving males with severe neonatal-onset encephalopathy, or with X-linked intellectual disability associated with psychosis, pyramidal signs, parkinsonian features and macro-orchidism (PPM-X syndrome; MIM3 #300055). Here we report on the identification of the p.Ala140Val mutation in the MECP2 gene in 4 males and 3 females of a large Caucasian family affected with X-linked intellectual disability. Females present with mild cognitive impairment and speech difficulties. Males have moderate intellectual disability, impaired language development, friendly behavior, slowly progressive spastic paraparesis and dystonic movements of the hands. Two of them show microcephaly. The p.Ala140Val mutation is recurrent, as it was already described in 4 families with X-linked mental retardation and in three sporadic male patients with intellectual disability. We further delineate the phenotype associated with the p.Ala140Val mutation, illustrating a variable expressivity even within a given family, and we compare our patients with previous reported cases in the literature.

  7. Long non-coding RNA MEG3 inhibits adipogenesis and promotes osteogenesis of human adipose-derived mesenchymal stem cells via miR-140-5p.

    Science.gov (United States)

    Li, Zheng; Jin, Chanyuan; Chen, Si; Zheng, Yunfei; Huang, Yiping; Jia, Lingfei; Ge, Wenshu; Zhou, Yongsheng

    2017-04-05

    lncRNAs are an emerging class of regulators involved in multiple biological processes. MEG3, an lncRNA, acts as a tumor suppressor, has been reported to be linked with osteogenic differentiation of MSCs. However, limited knowledge is available concerning the roles of MEG3 in the multilineage differentiation of hASCs. The current study demonstrated that MEG3 was downregulated during adipogenesis and upregulated during osteogenesis of hASCs. Further functional analysis showed that knockdown of MEG3 promoted adipogenic differentiation, whereas inhibited osteogenic differentiation of hASCs. Mechanically, MEG3 may execute its role via regulating miR-140-5p. Moreover, miR-140-5p was upregulated during adipogenesis and downregulated during osteogenesis in hASCs, which was negatively correlated with MEG3. In conclusion, MEG3 participated in the balance of adipogenic and osteogenic differentiation of hASCs, and the mechanism may be through regulating miR-140-5p.

  8. Effects of natural-cerebrolysin-containing serum on neurotoxicity and synaptogenesis in amyloid-beta 1-40-induced Alzheimer's disease in vitro models

    Institute of Scientific and Technical Information of China (English)

    Yinghong Li; Zhengzhi Wu; Andrew C. J. HuangO; Ming Li; XiaoLi Zhang; Jiguo Wang

    2009-01-01

    BACKGROUND: Neuronal loss, synapse mutilation, and increasing malnourished axons are pathologically related to Alzheimer's disease. Microtubule-associated protein 2 (MAP2) is of importance for neuronal, axonal, and dendritic generation, extension, and stabilization, as well as for the regulation of synaptic plasticity.OBJECTIVE: To investigate the antagonistic effects of natural-cerebrolysin-containing serum on beta amyloid protein 1-40 (Aβ1-40)-induced neurotoxicity from the standpoints of cell proliferation, synaptogenesis, and cytoskeleton formation (MAP2 expression).DESIGN, TIME AND SETTING: A paralleled, controlled, neural cell, and molecular biology experiment was performed at the Institute of Integrated Chinese and Western Medicine, Shenzhen Hospital, Southern Medical University between February 2006 and April 2008.MATERIALS: PC12 cells, derived from the rat central nervous system, were purchased from Shanghai Institute of Cell Biology, Chinese Academy of Sciences, China. A β1-40 was provided by Sigma, USA. Natural-cerebrolysin was provided by Shenzhen Institute of Integrated Chinese and Western Medicine, China. The natural-cerebrolysin was predominantly composed of Renshen (Radix Ginseng), Tianma (Rhizoma Gastrodiae), and Yixingye (Ginkgo Leaf) in a proportion of 1:2:2. Following conventional water extraction technology, an extract (1:20) was prepared. Each gram of extract equaled 20 grams of crude drug. In a total of 12 adult male New Zealand rabbits, six underwent intragastric administration of natural-cerebrolysin extract for 1 month to prepare administration of physiological saline to prepare normal blank serum.METHODS: An Alzheimer's disease in vitro model was induced in PC12 cells using Aβ1-40. The cells were incubated with varying doses of natural-cerebrolysin-containing serum (2.5%, 5%, and 10%). Normal blank serum-treated PC12 cells served as a blank control group.MAIN OUTCOME MEASURES: Through the use of inverted phase contrast microscope, cell

  9. Controlled-release law of A3NEP1-40 using serf-assembly nano-materials of RADA-IKVAV/FRM as carrier%载A3NEP1-40脊髓组织工程支架材料控释规律的研究

    Institute of Scientific and Technical Information of China (English)

    周建波; 郑启新; 李景峰; 吴贵; 胡志雷; 郝少飞

    2013-01-01

    Objective To mvestigate the controlled-release law of A3NEP1-40 encapsulated in the hydrogel of RADA-IKVAV/FRM formed by self-assembly.Methods DMEM/F12 solution can trigger RADA-IKVAV/FRM self-assembly into a porous homogeneous hydrogel,and encapsulate A3NEP1-40 into the internal voids of the hydrogel via hydrophobic interaction.The hydrogels containing 125 μg or 25 μg A3NEP1-40 were put a PBS buffer to formulate a controlled-release system.Four groups were created according to the load of A3NEP1-40 and the buffer volume labeled A,B,C,D.The concentration of A3NEP1-40 in the sample was detected by using high performance liquid chromatography,and the release amount of a day and the cumulative release amount were calculated.The SPSS13.0 statistical software was used to analyze the controlled-release law of A3NEP1-40.Results (1) At the first 24 h,there was a burst release phase,approximately 40% of the loaded A3NEP1-40 released from gel; in the steady release stage,sustainable A3NEP1-40 release could be detected in the sample for 40 days; (2) There was no statistically significant difference in the A3NEP1-40 release between group A and group B,or between group C and group D,but there was significant difference between groups A and C,groups A and D,groups B and C,or groups B and D (all P < 0.05).Condusion The release speed of A3 NEP1-40 can be controlled by self-assembly nanometer polypeptide gel materials and a sustained release effect can be achieved.Self-as-sembly nanometer polypeptide hydrogel containing RADA-IKVAV/FRM is a very good controlled-release carrier,and can be applied to nerve tissue engineering to promote spinal cord injury repair.%目的 探讨A3NEP1-40以RADA-IKVAV/FRM为载体的缓释规律.方法 DMEM/F12溶液能触发RADA-IKVAV/FRM自组装,包裹A3NEP1-40形成均质水凝胶.将包裹125 μg及25 μgA3NEP1-40的水凝胶各自放入2.5ml及0.5ml磷酸盐缓冲液(PBS)中进行释放,并依此分为A、B、C、D4组.应用高效液

  10. Effect of pseudoginseng on the contents of TXB2 and GMP-140 in plasma of experimental hyperlipidemic rabbit%三七对高脂血症家兔血浆TXB2、GMP-140含量的影响

    Institute of Scientific and Technical Information of China (English)

    李韬; 雷菠; 冯丽芬; 韦耀东

    2012-01-01

    Objective To investigate the effect of pseudoginseng on serum lipids and contents of thromboxane B2 (TXB2 ) and granule membrane protein-140 (GMP-140) in plasma of the experimental hyperlipidemic rabbits. Methods Eighteen healthy rabbits were equally randomized into three groups of B( fed with hyperlipemia diet for 6 weeks and administrated with pseudoginseng 0. 23 g · kg1 ·d1 from the beginning of the 3rd week),A(fed with hyperlipemia diet for 6 weeks and given same volume of normal saline) and C(fed with normal diet for 6 weeks and given same volume of normal saline). The levels of triglycerides (TG), total cholesterol (TC), high-density lipoproteins cholesteroK HDL-C) in serum were detected before experiment and on the 3rd, 6th week. The contents of TXBz,GMP-140 in plasma were detected on the 6th week. Results Compared with group A, the levels of TG, HDL-C in serum and contents of TXB2,GMP-140 in plasma were decreased in group B on the 6th week(P<0. 05). Conclusion Pseudoginseng is able to reduce serum lipids and plasma TXB2, GMP-140 levels, which can prevent and cure atherosclerosis and thrombotic cardio-cerebrovascular diseases.%目的 探讨三七粉对高脂血症家兔的降脂作用及对血浆血栓烷B2(TXB2)、α-颗粒膜蛋白140(GMP-140)含量的影响.方法 18只健康家兔随机均分为高脂血症组(A组)、高脂血症治疗组(B组)和对照组(C组).A、B组饲喂高脂饲料,C组饲喂普通饲料,共6周.第3周开始,B组灌服三七粉0.23g·kg-1·d-1,A、C组灌以等体积的生理盐水.分别于实验前、第3、6周时检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆同醇(HDL-C)水平,第6周时检测血浆中TXB2、GMP-140含量.结果 与A组相比,第6周时B组血清TG、HDL-C水平明显下降(P<0.05),血浆TXB2、GMp-140含量显著降低(P<0.01).结论 三七能降低血脂,抑制TXB2、GMP-140表达,对动脉粥样硬化和血栓性心脑血管疾病有较好的防治作用.

  11. miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells

    Science.gov (United States)

    Wei, Renxiong; Cao, Gang; Deng, Zhouming; Su, Jiajia; Cai, Lin

    2016-01-01

    Acquisition of drug-resistant phenotypes is often associated with chemotherapy in osteosarcoma. A number of studies have demonstrated a critical role for autophagy in osteosarcoma development, therapy and drug resistance. However, the molecular mechanisms underlying the autophagy-mediated chemotherapy resistance of osteosarcoma cells remain largely unknown. In the present study, we determined the autophagy and microRNA-140 (miR-140-5p, miRBase ID: MIMAT0000431) expression induced by chemotherapeutic drugs in osteosarcoma cells. Then we determined the promotory role of miR-140-5p to the chemotherapy-induced autophagy. Our results demonstrated that miR-140-5p expression was highly induced during chemotherapy of osteosarcoma cells, and this was accompanied by up-regulated autophagy. The increased miR-140-5p expression levels up-regulated anticancer drug-induced autophagy in osteosarcoma cells and ameliorated the anticancer drug-induced cell proliferation and viability decrease. Importantly, miR-140-5p regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (IP3k2). Therefore, the results of the present study demonstrated that miR-140-5p mediated drug-resistance in osteosarcoma cells by inducing autophagy. The present study provides evidence of miRNA regulation of autophagy through modulation of IP3 signalling. The present study recognized a novel mechanism of chemoresistance in osteosarcoma cancers. PMID:27582507

  12. Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase.

    Directory of Open Access Journals (Sweden)

    Daniele Repetto

    Full Text Available Protein phosphorylation tightly regulates specific binding of effector proteins that control many diverse biological functions of cells (e. g. signaling, migration and proliferation. p140Cap is an adaptor protein, specifically expressed in brain, testis and epithelial cells, that undergoes phosphorylation and tunes its interactions with other regulatory molecules via post-translation modification. In this work, using mass spectrometry, we found that p140Cap is in vivo phosphorylated on tyrosine (Y within the peptide GEGLpYADPYGLLHEGR (from now on referred to as EGLYA as well as on three serine residues. Consistently, EGLYA has the highest score of in silico prediction of p140Cap phosphorylation. To further investigate the p140Cap function, we performed site specific mutagenesis on tyrosines inserted in EGLYA and EPLYA, a second sequence with the same highest score of phosphorylation. The mutant protein, in which both EPLYA/EGLYA tyrosines were converted to phenylalanine, was no longer tyrosine phosphorylated, despite the presence of other tyrosine residues in p140Cap sequence. Moreover, this mutant lost its ability to bind the C-terminal Src kinase (Csk, previously shown to interact with p140Cap by Far Western analysis. In addition, we found that in vitro and in HEK-293 cells, the Abelson kinase is the major kinase involved in p140Cap tyrosine phosphorylation on the EPLYA and EGLYA sequences. Overall, these data represent an original attempt to in vivo characterise phosphorylated residues of p140Cap. Elucidating the function of p140Cap will provide novel insights into its biological activity not only in normal cells, but also in tumors.

  13. Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase.

    Science.gov (United States)

    Repetto, Daniele; Aramu, Simona; Boeri Erba, Elisabetta; Sharma, Nanaocha; Grasso, Silvia; Russo, Isabella; Jensen, Ole N; Cabodi, Sara; Turco, Emilia; Di Stefano, Paola; Defilippi, Paola

    2013-01-01

    Protein phosphorylation tightly regulates specific binding of effector proteins that control many diverse biological functions of cells (e. g. signaling, migration and proliferation). p140Cap is an adaptor protein, specifically expressed in brain, testis and epithelial cells, that undergoes phosphorylation and tunes its interactions with other regulatory molecules via post-translation modification. In this work, using mass spectrometry, we found that p140Cap is in vivo phosphorylated on tyrosine (Y) within the peptide GEGLpYADPYGLLHEGR (from now on referred to as EGLYA) as well as on three serine residues. Consistently, EGLYA has the highest score of in silico prediction of p140Cap phosphorylation. To further investigate the p140Cap function, we performed site specific mutagenesis on tyrosines inserted in EGLYA and EPLYA, a second sequence with the same highest score of phosphorylation. The mutant protein, in which both EPLYA/EGLYA tyrosines were converted to phenylalanine, was no longer tyrosine phosphorylated, despite the presence of other tyrosine residues in p140Cap sequence. Moreover, this mutant lost its ability to bind the C-terminal Src kinase (Csk), previously shown to interact with p140Cap by Far Western analysis. In addition, we found that in vitro and in HEK-293 cells, the Abelson kinase is the major kinase involved in p140Cap tyrosine phosphorylation on the EPLYA and EGLYA sequences. Overall, these data represent an original attempt to in vivo characterise phosphorylated residues of p140Cap. Elucidating the function of p140Cap will provide novel insights into its biological activity not only in normal cells, but also in tumors.

  14. Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation

    Directory of Open Access Journals (Sweden)

    Blue Mary

    2010-02-01

    Full Text Available Abstract Background Rett syndrome (RTT, a common cause of mental retardation in girls, is associated with mutations in the MECP2 gene. Most human cases of MECP2 mutation in girls result in classical or variant forms of RTT. When these same mutations occur in males, they often present as severe neonatal encephalopathy. However, some MECP2 mutations can also lead to diseases characterized as mental retardation syndromes, particularly in boys. One of these mutations, A140V, is a common, recurring missense mutation accounting for about 0.6% of all MeCP2 mutations and ranking 21st by frequency. It has been described in familial X-linked mental retardation (XLMR, PPM- X syndrome (Parkinsonism, Pyramidal signs, Macroorchidism, X-linked mental retardation and in other neuropsychiatric syndromes. Interestingly, this mutation has been reported to preserve the methyl-CpG binding function of the MeCP2 protein while compromising its ability to bind to the mental retardation associated protein ATRX. Results We report the construction and initial characterization of a mouse model expressing the A140V MeCP2 mutation. These initial descriptive studies in male hemizygous mice have revealed brain abnormalities seen in both RTT and mental retardation. The abnormalities found include increases in cell packing density in the brain and a significant reduction in the complexity of neuronal dendritic branching. In contrast to some MeCP2 mutation mouse models, the A140V mouse has an apparently normal lifespan and normal weight gain patterns with no obvious seizures, tremors, breathing difficulties or kyphosis. Conclusion We have identified various neurological abnormalities in this mouse model of Rett syndrome/X-linked mental retardation which may help to elucidate the manner in which MECP2 mutations cause neuronal changes resulting in mental retardation without the confounding effects of seizures, chronic hypoventilation, or other Rett syndrome associated symptoms.

  15. 大鼠海马内注射β淀粉样蛋白1-40抑制铜蓝蛋白表达%Decreasing ceruloplasmin expression induced by amyloid β-peptide (1-40)injection in rat hippocampus

    Institute of Scientific and Technical Information of China (English)

    李艳伟; 赵晋英; 周泽江; 黄泽智; 李琳

    2013-01-01

    0bjective:To explore the effects of amyloid beta-peptide 1-40 (Aβ1-40) on ceruloplasmin (Cp) expression in the hippocampus of rats.Methods:Male SD rats (290 ± 10 g) were injected Aβ1-40 in the hippocampus and their hippocampuses were obtained after injection 1 week,2 weeks,3 weeks and 4 weeks,respectively.The expression of GPI-Cp mRNA was measured by reverse transcription polymerase chain reaction (RT-PCR).The expression of GPI-Cp protein was examined by immunohistochemistry.Results:The expression of GPI-Cp mRNA and protein was shown in the hippocampus of rats,including epithelial cell of choroid plexus,ependymal cell,astrocyte of hippocampus and vascular endothelial cell,but mild in pyramidal cell and not in granulosa cell.The time-dependent decrease of GPI-Cp mRNA and protein expression were shown in the hippocampus of rats injected Aβ1-40 (P < 0.01).Conclusion:In the hippocampus of rats,the Aβ1-40 injection induced the decrease of GPI-Cp expression,which may result in increase of iron concentration of hippocampus and may be involved in the pathogenesis of AD.%目的:通过检测阿尔茨海默病(Alzheimer disease,AD)模型大鼠海马铜蓝蛋白(glycan-phosphatidylinositol ceruloplasmin,GPI-Cp)的变化,探讨AD时脑铁增高的机制.方法:取雄性(290±10)g SD大鼠,经海马内注射(amyloid beta-peptide 1-40,Aβ1-40)建立AD模型,于1、2、3和4周取各组大鼠脑组织,分离海马,用RT-PCR检测GPI-Cp mRNA表达情况,免疫组织化学染色检测GPI-Cp蛋白表达情况.结果:海马的星形胶质细胞、血管内皮细胞、室管膜细胞均有GPI-Cp的mRNA和蛋白表达;而海马的锥体细胞仅轻度表达,颗粒细胞不表达.注射Aβ1-40后,模型组海马GPI-Cp mRNA和蛋白表达均随着时间延长逐渐降低,具有统计学意义(P<0.01).结论:海马内注射Aβ1-40可引起大鼠海马GPI-Cp表达减少,GPI-Cp表达减少可能是AD时脑铁增高的原因.

  16. ISEE 3 observations during a plasma sheet encounter at 140 earth radii - Evidence for enhancement of reconnection at the distant neutral line

    Science.gov (United States)

    Scholer, M.; Terasawa, T.; Baker, D. N.; Zwickl, R. D.; Gloeckler, G.; Hovestadt, D.; Smith, E. J.; Tsurutani, B. T.

    1986-01-01

    A plasma sheet encounter of the ISEE-3 spacecraft in the distant tail at 140 earth radii on March 20, 1983 is studied using magnetic field, energetic particle, and plasma electron data sets. The H-component magnetograms from auroral magnetometer stations, intensity-time profiles, high resolution magnetic field measurements, and electron and proton angular distributions are analyzed. The dynamics of the plasma sheet displayed by the strong tailward and earthward directed ion beams, large northward and southward magnetic fields excursions, and short tailward and earthward plasma flows are described.

  17. Airside HVAC BESTEST. Adaptation of ASHRAE RP 865 Airside HVAC Equipment Modeling Test Cases for ASHRAE Standard 140. Volume 1, Cases AE101-AE445

    Energy Technology Data Exchange (ETDEWEB)

    Neymark, J. [J. Neymark & Associates, Golden, CO (United States); Kennedy, M. [Mike D. Kennedy, Inc., Townsend, WA (United States); Judkoff, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gall, J. [AAON, Inc., Tulsa, OK (United States); Knebel, D. [AAON, Inc., Tulsa, OK (United States); Henninger, R. [GARD Analytics, Inc., Arlington Heights, IL (United States); Witte, M. [GARD Analytics, Inc., Arlington Heights, IL (United States); Hong, T. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McDowell, T. [Thermal Energy System Specialists, Madison, WI (United States); Yan, D. [Tsinghua Univ., Beijing (China); Zhou, X. [Tsinghua Univ., Beijing (China)

    2016-03-01

    This report documents a set of diagnostic analytical verification cases for testing the ability of whole building simulation software to model the air distribution side of typical heating, ventilating and air conditioning (HVAC) equipment. These cases complement the unitary equipment cases included in American National Standards Institute (ANSI)/American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs, which test the ability to model the heat-transfer fluid side of HVAC equipment.

  18. Reduced neuronal size and mTOR pathway activity in the Mecp2 A140V Rett syndrome mouse model [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Sampathkumar Rangasamy

    2016-09-01

    Full Text Available Rett syndrome (RTT is a neurodevelopmental disorder caused by mutation in the X-linked MECP2 gene, encoding methyl-CpG-binding protein 2. We have created a mouse model (Mecp2 A140V “knock-in” mutant expressing the recurrent human MECP2 A140V mutation linked to an X-linked mental retardation/Rett syndrome phenotype. Morphological analyses focused on quantifying soma and nucleus size were performed on primary hippocampus and cerebellum granule neuron (CGN cultures from mutant (Mecp2A140V/y and wild type (Mecp2+/y male mice. Cultured hippocampus and cerebellar granule neurons from mutant animals were significantly smaller than neurons from wild type animals. We also examined soma size in hippocampus neurons from individual female transgenic mice that express both a mutant  (maternal allele and a wild type Mecp2 gene linked to an eGFP transgene (paternal allele. In cultures from such doubly heterozygous female mice, the size of neurons expressing the mutant (A140V allele also showed a significant reduction compared to neurons expressing wild type MeCP2, supporting a cell-autonomous role for MeCP2 in neuronal development. IGF-1 (insulin growth factor-1 treatment of neuronal cells from Mecp2 mutant mice rescued the soma size phenotype. We also found that Mecp2  mutation leads to down-regulation of the mTOR signaling pathway, known to be involved in neuronal size regulation. Our results suggest that i reduced neuronal size is an important in vitro cellular phenotype of Mecp2 mutation in mice, and ii MeCP2 might play a critical role in the maintenance of neuronal structure by modulation of the mTOR pathway. The definition of a quantifiable cellular phenotype supports using neuronal size as a biomarker in the development of a high-throughput, in vitro assay to screen for compounds that rescue small neuronal phenotype (“phenotypic assay”.

  19. Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still’s Disease: A Multicentre Retrospective Observational Study

    Directory of Open Access Journals (Sweden)

    Serena Colafrancesco

    2017-06-01

    Full Text Available Background: Interleukin (IL-1 plays a crucial role in the pathogenesis of Adult onset Still’s disease (AOSD.Objectives: To evaluate the efficacy and safety of anakinra (ANA and canakinumab (CAN in a large group of AOSD patients.Methods: Data on clinical, serological features, and concomitant treatments were retrospectively collected at baseline and after 3, 6, and 12 months from AOSD patients (Yamaguchi criteria referred by 18 Italian centers. Pouchot’s score was used to evaluate disease severity.Results: One hundred forty patients were treated with ANA; 4 were subsequently switched to CAN after ANA failure. The systemic pattern of AOSD was identified in 104 (74.2% of the ANA-treated and in 3 (75% of the CAN-treated groups; the chronic-articular type of AOSD was identified in 48 (25.8% of the ANA-treated and in 1 (25% of the CAN-treated groups. Methotrexate (MTX was the most frequent disease modifying anti-rheumatic drug (DMARD used before beginning ANA or CAN [91/140 (75.8%, 2/4 (50%, respectively]. As a second-line biologic DMARD therapy in 29/140 (20.7% of the patients, ANA was found effective in improving all clinical and serological manifestations (p < 0.0001, and Pouchot’s score was found to be significantly reduced at all time points (p < 0.0001. No differences in treatment response were identified in the ANA-group when the patients were stratified according to age, sex, disease pattern or mono/combination therapy profile. ANA primary and secondary inefficacy at the 12-month time point was 15/140 (10.7% and 11/140 (7.8%, respectively. Adverse events (AEs [mainly represented by in situ (28/47, 59.5% or diffuse (12/47, 25.5% skin reactions and infections (7/47, 14.8%] were the main causes for discontinuation. Pouchot’s score and clinical and serological features were significantly ameliorated at all time points (p < 0.0001 in the CAN-group, and no AEs were registered during CAN therapy. Treatment was suspended for loss of efficacy

  20. 扬子石化140万t/a芳烃和105万t/aPTA通过验收

    Institute of Scientific and Technical Information of China (English)

    孙可华

    2008-01-01

    扬子石化公司140万t/a芳烃和45万t/aPTA改扩建项目,通过了由中国石化股份公司、江苏省和南京市组成的竣工验收委员会的竣工验收。这两个项目是中国石化“十五”期间的重大技术改造项目,2004年开工,2006年建成投产。