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Sample records for dyspepsia

  1. Functional dyspepsia

    NARCIS (Netherlands)

    Kleibeuker, JH; Thijs, JC

    2004-01-01

    Purpose of review Functional dyspepsia is a common disorder, most of the time of unknown etiology and with variable pathophysiology. Therapy has been and still is largely empirical. Data from recent studies provide new clues for targeted therapy based on knowledge of etiology and pathophysiologic me

  2. Ghrelin and Functional Dyspepsia

    Directory of Open Access Journals (Sweden)

    Takashi Akamizu

    2010-01-01

    Full Text Available The majority of patients with dyspepsia have no identifiable cause of their disease, leading to a diagnosis of functional dyspepsia (FD. While a number of different factors affect gut activity, components of the nervous and endocrine systems are essential for normal gut function. Communication between the brain and gut occurs via direct neural connections or endocrine signaling events. Ghrelin, a peptide produced by the stomach, affects gastric motility/emptying and secretion, suggesting it may play a pathophysiological role in FD. It is also possible that the functional abnormalities in FD may affect ghrelin production in the stomach. Plasma ghrelin levels are reported to be altered in FD, correlating with FD symptom score. Furthermore, some patients with FD suffer from anorexia with body-weight loss. As ghrelin increases gastric emptying and promotes feeding, ghrelin therapy may be a new approach to the treatment of FD.

  3. Subtypes of functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Georgina Baker; Robert J Fraser; Graeme Young

    2006-01-01

    Functional dyspepsia is a common clinical condition characterised by chronic or recurrent upper abdominal pain or discomfort commonly associated with a variety of associated gastrointestinal symptoms and a normal endoscopy. To standardise research-based approaches,an initial categorisation of into sub groups was agreed to, based on clusters of symptoms. However the early expectation that these subgroups would be associated with distinct pathophysiologies amenable to specific therapy has not been realised. A classification based on the most troublesome symptom has been suggested but the utility of this is also unclear. More recent data suggest that some of the pathophysiologic dysfunctions may be associated with specific symptoms and so provide a better tool for grouping patients. But this approach remains incomplete as current insights into the pathogenesis are still too limited for this to be satisfactory. In conclusion, no classification provides for an adequate treatment-based approach to the syndrome of functional dyspepsia. As a consequence treatment remains largely empiric.

  4. Dyspepsia management in primary care

    NARCIS (Netherlands)

    Thijs, JC; Arents, NLA; van Zwet, AA; Kleibeuker, JH

    2003-01-01

    Background: Dyspepsia is common in western society. Prompt endoscopy is imperative in all patients with sinister symptoms or if symptoms first appear after the age of 50-55 years, but the optimal management of younger patients with uncomplicated dyspepsia is still open to debate. Methods: The litera

  5. Drug treatment of functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Klaus M(o)nkemüller; Peter Malfertheiner

    2006-01-01

    Symptomatic improvement of patients with functional dyspepsia after drug therapy is often incomplete and obtained in not more than 60% of patients. This is likely because functional dyspepsia is a heterogeneous disease.Although great advance has been achieved with the consensus definitions of the Rome Ⅰ and Ⅱ criteria, there are still some aspects about the definition of functional dyspepsia that require clarification. The Rome criteria explicitly recognise that epigastric pain or discomfort must be the predominant complaint in patients labelled as suffering from functional dyspepsia. However, this strict definition can create problems in the daily primary care clinical practice, where the patient with functional dyspepsia presents with multiple symptoms. Before starting drug therapy it is recommended to provide the patient with an explanation of the disease process and reassurance. A thorough physical examination and judicious use of laboratory data and endoscopy are also indicated. In general, the approach to treat patients with functional dyspepsia based on their main symptom is practical and effective. Generally, patients should be treated with acid suppressive therapy using proton-pump inhibitors if the predominant symptoms are epigastric pain or gastroesophageal reflux symptoms. Although the role of Helicobacter pylori(H pylori) in functional dyspepsia continues to be a matter of debate, recent data indicate that there is modest but clear benefit of eradication of H pylori in patients with functional dyspepsia. In addition,H pylori is a gastric carcinogen arid if found it should be eliminated. Although there are no specific diets for patients with FD, it may be helpful to guide the patients on healthy exercise and eating habits.

  6. A Suggested Approach to Patients with Dyspepsia

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    ABR Thomson

    1997-01-01

    Full Text Available A comprehensive review of dyspepsia is presented. Topics include causes of dyspepsia, prevalence, causes of symptoms (motility abnormalities, visceral hypersensitivity, psychosocial aspects, role of Helicobacter pylori, investigations of patients with dyspepsia and, finally, whether there is effective treatment.

  7. Role of Helicobacter pylori in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Colm O'Morain

    2006-01-01

    The aetiology of dyspepsia is unknown in the majority of patients. Helicobacter pylori(H pylori) is the cause in a subset of patients. A non invasive test to assess the presence of H pylori is recommended in the management of patients under the age of 50 presenting to a family practitioner with dyspepsia. A urea breath test or a stool antigen test are the most reliable non invasive tests. Eradication of H pylori will reduce the risk to the patient with dyspepsia of developing a peptic ulcer, reduce the complication rate if prescribed nonsteroid anti-inflammatory drugs and later reduce the risk of gastric cancer. The recommended treatment for non ulcer dyspepsia associated with a H pylori infection should be a 10-d course of treatment with a PPI and two antibiotics. Treatment efficacy should be assessed four weeks after completing treatment with a urea breath test or a stool antigen test.

  8. Epidemiology of functional dyspepsia: A global perspective

    Institute of Scientific and Technical Information of China (English)

    Sanjiv Mahadeva; Khean-Lee Goh

    2006-01-01

    Dyspepsia refers to group of upper gastrointestinal symptoms that occur commonly in adults. Dyspepsia is known to result from organic causes, but the majority of patients suffer from non-ulcer or functional dyspepsia.Epidemiological data from population-based studies of various geographical locations have been reviewed, as they provide more realistic information. Population-based studies on true functional dyspepsia (FD) are few, due to the logistic difficulties of excluding structural disease in large numbers of people. Globally, the prevalence of uninvestigated dyspepsia (UD) varies between 7%-45%, depending on definition used and geographical location, whilst the prevalence of FD has been noted to vary between 11%-29.2%. Risk factors for FD have been shown to include females and underlying psychological disturbances, whilst environmental/lifestyle habits such as poor socio-economic status, smoking,increased caffeine intake and ingestion of non-steroidal anti-inflammatory drugs appear to be more relevant to UD. It is clear that dyspepsia and FD in particular are common conditions globally, affecting most populations,regardless of location.

  9. Cholecystokinin hyperresponsiveness in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    ASB Chua; PWN Keeling

    2006-01-01

    Functional dyspepsia (FD) is a common disorder of yet uncertain etiology. Dyspeptic symptoms are usually meal related and suggest an association to gastrointestinal (GI) sensorimotor dysfunction. Cholecystokinin (CCK) is an established brain-gut peptide that plays an important regulatory role in gastrointestinal function. It inhibits gastric motility and emptying via a capsaicin sensitive vagal pathway. The effects on emptying are via its action on the proximal stomach and pylorus. CCK is also involved in the regulation of food intake. It is released in the gut in response to a meal and acts via vagal afferents to induce satiety. Furthermore CCK has also been shown to be involved in the pathogenesis of panic disorder, anxiety and pain. Other neurotransmitters such as serotonin and noradrenaline may be implicated with CCK in the coordination of GI activity. In addition,intravenous administration of CCK has been observed to reproduce the symptoms in FD and this effect can be blocked both by atropine and Ioxiglumide (CCK-A antagonist). It is possible that an altered response to CCK may be responsible for the commonly observed gastric sensorimotor dysfunction, which may then be associated with the genesis of dyspeptic symptoms.

  10. Adherence to best practice guidelines in dyspepsia: a survey comparing dyspepsia experts, community gastroenterologists and primary-care providers.

    NARCIS (Netherlands)

    Spiegel, B.M.; Farid, M.; Oijen, M.G.H. van; Laine, L.; Howden, C.W.; Esrailian, E.

    2009-01-01

    BACKGROUND: Although 'best practice' guidelines for dyspepsia management have been disseminated, it remains unclear whether providers adhere to these guidelines. AIM: To compare adherence to 'best practice' guidelines among dyspepsia experts, community gastroenterologists and primary-care providers

  11. Management of upper dyspepsia in general practice

    DEFF Research Database (Denmark)

    Kjeldsen, Hans Christian; Kier, Svend; Husum, Gitte

     Aim: To compare the effect of two strategies for management of dyspepsia. Evaluation based on GP's assessment after two weeks and patients assessment after three months.   Design: Prospective randomised controlled trial in general practice   Methods: 357 patients with dyspepsia where the general......) for two weeks. If symptoms were unchanged after to weeks => referral to endoscopy. Later recurrence of symptoms => endoscopy (> 45 year) or management strategy according to helicobacter pylori status and/or clinical reflux (measures......)   Conclusion In management of dyspepsia therapy does have a better short term effect than endoscopy concerning symptom relief, but after 3 months the endoscopy strategy had a better effect than PPI concerning symptom relief  ...

  12. Management of upper dyspepsia in general practice

    DEFF Research Database (Denmark)

    Kjeldsen, Hans Christian; Kier, Svend; Husum, Gitte

    of dyspepsia, dyspeptic episodes, main symptom, previous contact to general practice, previous gastroscopia, use of antacids or NSAID's, Helicobacter Pylori status and mental/physical well being (SF-36 measurement scale) (Table 1). After two weeks the GPs assessed 46 % of the patients to be free of symptoms...... Aim: To compare the effect of two strategies for management of dyspepsia. Evaluation based on GP's assessment after two weeks and patients assessment after three months.   Design: Prospective randomised controlled trial in general practice   Methods: 357 patients with dyspepsia where the general...... after 3 months.   Results: Response rate GPs after two weeks were 92% (330/357). Response rate patients after three months were 71% (252/357). There were no significant difference between the groups randomised to strategy 1(PPI group) and strategy 2 (endoscopy group) concerning, age, gender, duration...

  13. Gastritis, dyspepsia and peptic ulcer disease.

    Science.gov (United States)

    Dore, M P; Graham, D Y

    2008-06-01

    Peptic ulcer disease remains a common problem and it most frequently due to the presence of an Helicobacter pylori infection or use of non-steroidal anti-inflammatory drugs (NSAIDs). Dyspepsia is neither sensitive or specific for diagnosing peptic ulcer disease. The approach to patients with dyspepsia is to arrive at a definitive diagnosis without unnecessary exposure to invasive or costly diagnostic procedures. Non-invasive testing is preferred with endoscopy being reserved for those with alarm markers or above a specified age (e.g., 55 years in Western countries). Patients negative for H. pylori infection should receive an empiric trial of acid suppression for 4 to 8 weeks and if beneficial it can be continued.

  14. Reassessment of functional dyspepsia: A topic review

    Institute of Scientific and Technical Information of China (English)

    Andrew Seng Boon Chua

    2006-01-01

    Dyspepsia itself is not a diagnosis but stands for a constellation of symptoms referable to the upper gastrointestinal tract. It consists of a variable combination of symptoms including abdominal pain or discomfort, postprandial fullness, abdominal bloating,early satiety, nausea, vomiting, heartburn and acid regurgitation. Patients with heartburn and acid regurgitation invariably have gastroesophageal reflux disease and should be distinguished from those with dyspepsia. There is a substantial group of patients who do not have a definite structural or biochemical cause for their symptoms and are considered to be suffering from functional dyspepsia (FD). Gastrointestinal motor abnormalities, altered visceral sensation, dysfunctional central nervous system-enteral nervous system (CNSENS) integration and psychosocial factors have all being identified as important pathophysiological correlates. It can be considered as a biopsychosocial disorder with dysregulation of the brain-gut axis being central in origin of disease. FD can be categorized into different subgroups based on the predominant single symptom identified by the patient. This subgroup classification can assist us in deciding the appropriate symptomatic treatment for the patient.

  15. Functional dyspepsia: not all roads seem to lead to rome.

    NARCIS (Netherlands)

    Kerkhoven, L.A.S. van; Laheij, R.J.F.; Meineche-Schmidt, V.; Veldhuyzen-van Zanten, S.J.; Wit, N.J. de; Jansen, J.B.M.J.

    2009-01-01

    BACKGROUND: The Rome criteria have been introduced to create order in the heterogeneity of functional dyspepsia. The applicability of these symptom-based classification systems remains controversial. GOAL: To evaluate the successive Rome criteria for functional dyspepsia in a large pool of patients

  16. [Construction of a online database for functional dyspepsia].

    Science.gov (United States)

    Huang, Zaiwei; Chen, Liping; Xiao, Bing

    2015-06-01

    To establish a clinical database of functional dyspepsia for epidemiological researches and standardizing clinical diagnosis and treatment. The functional dyspepsia database was designed to incorporate the data from in-patients and out-patients with functional dyspepsia treated since July, 2013 and was constructed using Visual Studio. The patient data were collected using a customized case report form designed according to the Roman criteria III and the etiology, symptoms, and treatments of the patients. All the cases deemed ineligible were excluded. The database was displayed on a website and allowed online data entry, case searches and statistical analysis of the clinical parameters. The established online database for functional dyspepsia contained data of the general information, clinical symptoms, psychological status, living habits, dietary habits, medical history, examination results, clinical diagnosis, treatment methods and courses, outcomes and data statistics. The database was fully functional and provided complete and standardized data of functional dyspepsia for clinical studies.

  17. Food and functional dyspepsia: a systematic review.

    Science.gov (United States)

    Duncanson, K R; Talley, N J; Walker, M M; Burrows, T L

    2017-09-15

    Functional dyspepsia (FD) is a debilitating functional gastrointestinal disorder characterised by early satiety, post-prandial fullness or epigastric pain related to meals, which affects up to 20% of western populations. A high dietary fat intake has been linked to FD and duodenal eosinophilia has been noted in FD. We hypothesised that an allergen such as wheat is a risk factor for FD and that withdrawal will improve symptoms of FD. We aimed to investigate the relationship between food and functional dyspepsia. Sixteen out of 6451 studies identified in a database search of six databases met the inclusion criteria of studies examining the effect of nutrients, foods and food components in adults with FD or FD symptoms. Wheat-containing foods were implicated in FD symptom induction in six studies, four of which were not specifically investigating gluten and two that were gluten-specific, with the implementation of a gluten-free diet demonstrating a reduction in symptoms. Dietary fat was associated with FD in all three studies that specifically measured this association. Specific foods reported as inducing symptoms were high in either natural food chemicals, high in fermentable carbohydrates or high in wheat/gluten. Caffeine was associated with FD in four studies, although any association with alcohol was uncertain. Wheat and dietary fats may play key roles in the generation of FD symptoms and reduction or withdrawal eased symptoms. Randomised trials investigating the roles of gluten, FODMAPs (fermentable oligosaccharide, disaccharide, monosaccharide and polyols) and high fat ingestion and naturally occurring food chemicals in the generation of functional dyspepsia symptoms are warranted and further investigation of the mechanisms is now required. © 2017 The British Dietetic Association Ltd.

  18. Dietary and lifestyle factors in functional dyspepsia.

    Science.gov (United States)

    Feinle-Bisset, Christine; Azpiroz, Fernando

    2013-03-01

    Dietary factors are increasingly recognized to have an important role in triggering symptoms in a large proportion of patients with functional dyspepsia. Fatty foods seem to be the main culprits, but other foods (including carbohydrate-containing foods, milk and dairy products, citrus fruits, spicy foods, coffee and alcohol) have also been implicated. However, blind challenge tests do not provide consistent results. Moreover, although patients identify specific foods as triggers of their symptoms, these patients often do not seem to make behavioural adjustments in an attempt to improve symptoms; that is, any differences in dietary intake and lifestyle between patients and healthy individuals are small. Patients with functional dyspepsia exhibit mixed sensory-motor abnormalities, such as gastric hypersensitivity and impaired gastric accommodation of a meal. Nutrients, particularly fat, exacerbate these abnormalities and might thereby trigger postprandial symptoms. Cognitive factors, including anticipation related to previous negative experience with certain foods, might also have a role in triggering symptoms. Studies evaluating the potential beneficial effect of dietary interventions and changes in lifestyle are lacking, and this Review outlines a number of options that could be used as starting points for meaningful large-scale studies in the future.

  19. Defining functional dyspepsia Definiendo la dispepsia funcional

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    Fermín Mearin

    2011-12-01

    Full Text Available Dyspepsia and functional dyspepsia represent a highly significant public health issue. A good definition of dyspepsia is key for helping us to better approach symptoms, decision making, and therapy indications. During the last few years many attempts were made at establishing a definition of dyspepsia. Results were little successful on most occasions, and clear discrepancies arose on whether symptoms should be associated with digestion, which types of symptoms were to be included, which anatomic location should symptoms have, etc. The Rome III Committee defined dyspepsia as "a symptom or set of symptoms that most physicians consider to originate from the gastroduodenal area", including the following: postprandial heaviness, early satiety, and epigastric pain or burning. Two new entities were defined: a food-induced dyspeptic symptoms (postprandial distress syndrome; and b epigastric pain (epigastric pain syndrome. These and other definitions have shown both strengths and weaknesses. At times they have been much too complex, at times much too simple; furthermore, they have commonly erred on the side of being inaccurate and impractical. On the other hand, some (the most recent ones are difficult to translate into the Spanish language. In a meeting of gastroenterologists with a special interest in digestive functional disorders, the various aspects of dyspepsia definition were discussed and put to the vote, and the following conclusions were arrived at: dyspepsia is defined as a set of symptoms, either related or unrelated to food ingestion, localized on the upper half of the abdomen. They include: a epigastric discomfort (as a category of severity or pain; b postprandial heaviness; and c early satiety. Associated complaints include: nausea, belching, bloating, and epigastric burn (heartburn. All these must be scored according to severity and frequency. Furthermore, psychological factors may be involved in the origin of functional dyspepsia. On the

  20. Plasma levels of acylated ghrelin in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Yeon Soo Kim; Joon Seong Lee; Tae Hee Lee; Joo Young Cho; Jin Oh Kim; Wan Jung Kim; Hyun Gun Kim; Seong Ran Jeon; Hoe Su Jeong

    2012-01-01

    AIM:To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional dyspepsia.METHODS:Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the study.The functional dyspepsia patients were each diagnosed based on the Rome Ⅲ criteria.Eligible patients completed a questionnaire concerning the severity of 10 symptoms.Plasma acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit; electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 kcal.RESULTS:There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional dyspepsia.However,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain (r =-0.427,P =0.047) and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety (r =0.428,P =0.047).Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria (%) (r =-0.522,P =0.013).Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the meal.CONCLUSION:Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia.

  1. [Research progress of mechanism of functional dyspepsia treated with acupuncture].

    Science.gov (United States)

    Yan, Kaiwei; Zhao, Ling; Yang, Jie; Lan, Ying; Xu, Jing; Wei, Chenchen; Liang, Fanrong

    2015-09-01

    Literature about functional dyspepsia treated with acupuncture in recent 5 years is retrieved in China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed. The research achievements are arranged and summed up to explore the mechanism of acupuncture for functional dyspepsia. It is found that acupuncture can regulate the secretion of braingut petide, and cause the coordination response of limbic system-brain. Also, it adjusts serum molecule metabolin and the gene expression of the transduction pathway of adjustment signal for rats. It is believed that functional dyspepsia treated with acupuncture is through multiple ways, and adjusting the function of braingut axis is one of the important mechanisms.

  2. Value of the Likert dyspepsia scale in differentiation of functional and organic dyspepsia in children.

    Science.gov (United States)

    Canan, Oguz; Ozcay, Figen; Ozbay-Hosnut, Ferda; Yazici, Canan; Bilezikci, Banu

    2011-04-01

    Dyspeptic symptoms may not allow clinicians to differentiate organic and functional gastrointestinal disorders. According to our dyspeptic patients' answers to dyspepsia questionnaire, we aimed to define the symptom scores directing organic dyspepsia (OD) before upper gastrointestinal endoscopy. One hundred sixty-one patients (ages 10-17 years, mean 13.5 ± 2.3 years, male/female: 2/3) with chronic upper gastrointestinal system symptoms lasting for at least 3 months were enrolled. Patients with predominated reflux symptoms were excluded by 24-hour pH monitoring. Before upper gastrointestinal endoscopy, severity and incidence of 8 gastrointestinal symptoms (epigastric pain, upper abdominal discomfort, retrosternal pyrosis, bitter or sour taste in mouth, halitosis, belching, nausea, and early satiety) were measured by 5-point Likert scale. Total score indicated severity score multiplied by incidence score. Antral biopsy samples were obtained. OD is defined as peptic ulcer, erosive esophagitis, erosive or nodular gastritis, and erosive duodenitis in endoscopy and/or moderate to severe antral gastritis in histology. Functional dyspepsia (FD) is defined as normal findings/mucosal hyperemia in endoscopy and/or mild antral gastritis in antral histology. We evaluated the relation among severity and incidence scores of each dyspeptic symptom in patients with OD or FD. Age, sex, body mass index, drug history, nutritional habits, the quality of life related to dyspepsia were also investigated in patients with OD and FD. According to patients' histological and endoscopic findings, 100 (62%) patients were in the OD group and 61 (38%) patients were in the FD group. Of the dyspeptic complaints, the severity, incidence, and total scores of epigastric pain were significantly correlated with dyspepsia type (respectively, P = 0.042, P = 0.028, and P = 0.005). Of 93 patients who had an epigastric pain severity of 4 and 5 (namely, moderate to severe pain), 65 (70%) patients were in the

  3. Lactobacillus probiotics for treating functional dyspepsia in children

    Directory of Open Access Journals (Sweden)

    Tuty Ahyani

    2016-05-01

    Conclusion There are no significant differences in recovery from functional dyspepsia, pain severity, or pain duration between the probiotics and placebo groups. However, the probiotics group has significantly reduced frequency of pain compared to that of the placebo group.

  4. Central serotonergic and noradrenergic receptors in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    S O'Mahony; TG Dinan; PW Keeling; ASB Chua

    2006-01-01

    Functional dyspepsia is a symptom complex characterised by upper abdominal discomfort or pain, early satiety,motor abnormalities, abdominal bloating and nausea in the absence of organic disease. The central nervous system plays an important role in the conducting and processing of visceral signals. Alterations in brain processing of pain, perception and affective responses may be key factors in the pathogenesis of functional dyspepsia. Central serotonergic and noradrenergic receptor systems are involved in the processing of motor,sensory and secretory activities of the gastrointestinal tract. Visceral hypersensitivity is currently regarded as the mechanism responsible for both motor alterations and abdominal pain in functional dyspepsia. Some studies suggest that there are alterations in central serotonergic and noradrenergic systems which may partially explain some of the symptoms of functional dyspepsia. Alterations in the autonomic nervous system may be implicated in the motor abnormalities and increases in visceral sensitivity in these patients.Noradrenaline is the main neurotransmitter in the sympathetic nervous system and again alterations in the functioning of this system may lead to changes in motor function. Functional dyspepsia causes considerable burden on the patient and society. The pathophysiology of functional dyspepsia is not fully understood but alterations in central processing by the serotonergic and noradrenergic systems may provide plausible explanations for at least some of the symptoms and offer possible treatment targets for the future.

  5. [Guidelines for the treatment of functional dyspepsia].

    Science.gov (United States)

    Jee, Sam Ryong; Jung, Hye Kyung; Min, Byung Hoon; Choi, Kee Don; Rhee, Poong Lyul; Kang, Young Woo; Lee, Sang In

    2011-02-01

    Functional dyspepsia (FD) is defined as the presence of symptoms thought to originate in the gastroduodenal area, in the absence of any organic, systemic, or metabolic disease that is likely to explain the symptoms. Based on the available evidence and consensus opinion, thirteen consensus statements for the treatment of FD were developed using the modified Delphi approach. Proton pump inhibitor, prokinetics, and histamine 2 receptor antagonists are effective for the treatment of FD. Mucosal protecting agents, fundus relaxant, and drugs for visceral hypersensitivity can improve symptoms in FD. Antacids and antidepressants may help improving symptoms in FD. Comparing endoscopy with 'test and treat' of Helicobacter pylori, endoscopy may be more effective initial strategy for managing patients with FD in Korea given high incidence of gastric cancer and low cost of endoscopy. Helicobacter pylori eradication can be one of the therapeutic options for patients with FD. Psychotherapy is effective for those who have severe symptoms and refractoriness. Further studies are strongly needed to develop better treatment strategies for Korean patients with FD.

  6. Functional dyspepsia: Are psychosocial factors of relevance?

    Institute of Scientific and Technical Information of China (English)

    Sandra Barry; Timothy G Dinan

    2006-01-01

    The pathogenesis of Functional Dyspepsia (FD) remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease.Using this paradigm, dysregulation of the reciprocal communication between the brain and the gut is central to symptom generation, interpretation and exacerbation.Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant.The view that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intrinsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome will facilitate effective management.Co-morbid psychiatric illness warrants treatment with conventional therapies. Acknowledging the relevance of psychosocial variables in FD, the degree of which is subject to variation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those with chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.

  7. Effectiveness of amitriptyline for treating functional dyspepsia in adolescents

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    Indra Mustawa

    2017-01-01

    Full Text Available Background Functional dyspepsia is common among adolescents. Pain reduces children’s quality of life, psychosocial functioning, and school attendance. Amitriptyline is assumed to be one of the alternative treatments in functional dyspepsia. Objective To investigate the effectiveness of amytriptyline as a treatment  for  functional dyspepsia in adolescents. Methods We conducted a randomized, single-blind, controlled trial from January to March 2011 in junior and senior high school students in Dobo City, Aru Island District, Maluku Province. Adolescents suffering from functional dyspepsia and who fulfilled the inclusion criteria were eligible for the study. Subjects were randomized into two groups. Each group received 10 mg (for body weight < 35 kg or 20 mg (for body weight ≥ 35 kg amitriptyline or placebo once per day for 28 days. Pain frequency was measured in terms of abdominal pain episodes per month, and duration was measured in minutes. Data were analyzed using t-test. Results Eighty-eight students participated in this study: the amitriptyline group (43 subjects and the placebo group (45 subjects. There were no statistically significant differences between the amitriptyline and placebo groups in frequency (P=0.777; 95%CI -0.846 to 1.129 or duration (P=0.728 of abdominal pain after treatment. Conclusion  Amitriptyline is not more effective than placebo for treating functional dyspepsia in adolescents.

  8. The significance of Helicobacter pylori in the approach of dyspepsia in primary care

    NARCIS (Netherlands)

    Arents, Nicolaas Lodevikus Augustinus

    2003-01-01

    Summary and conclusions In this thesis the management of dyspepsia in primary care in relation to Helicobacter pylori (H. pylori) infection was studied. In chapter two several important issues considering the approach of dyspepsia are discussed. It is clear that dyspepsia is not a disease but merely

  9. The significance of Helicobacter pylori in the approach of dyspepsia in primary care

    NARCIS (Netherlands)

    Arents, Nicolaas Lodevikus Augustinus

    2003-01-01

    Summary and conclusions In this thesis the management of dyspepsia in primary care in relation to Helicobacter pylori (H. pylori) infection was studied. In chapter two several important issues considering the approach of dyspepsia are discussed. It is clear that dyspepsia is not a disease but merely

  10. Profile of acotiamide in the treatment of functional dyspepsia

    Directory of Open Access Journals (Sweden)

    Ueda M

    2016-04-01

    Full Text Available Masahiro Ueda,1 Eisuke Iwasaki,1 Hidekazu Suzuki2 1Department of Internal Medicine, Division of Gastroenterology and Hepatology, 2Medical Education Center, Keio University School of Medicine, Tokyo, Japan Abstract: Efficacy of acotiamide for improving symptoms in patients with functional dyspepsia was shown by several clinical trials. In a randomized, double-blind, placebo-controlled, parallel-group comparative Phase III trial conducted in Japan, 100 mg of acotiamide three times a day for 4 weeks was more effective than a placebo for improving symptoms, and quality of life. Acotiamide was well-tolerated treatment, with no significant adverse events. The aim of this review was to summarize the current evidence of the efficacy of acotiamide in the treatment of patients with functional dyspepsia. Keywords: functional dyspepsia, acotiamide, acetylcholinesterase, Rome III

  11. Herbal Remedies for Functional Dyspepsia and Traditional Iranian Medicine Perspective

    Science.gov (United States)

    Babaeian, Mahmoud; Naseri, Mohsen; Kamalinejad, Mohammad; Ghaffari, Farzaneh; Emadi, Fatemeh; Feizi, Awat; Hosseini Yekta, Nafiseh; Adibi, Peyman

    2015-01-01

    Context: Functional dyspepsia (FD) is a functional gastro-intestinal disorder with high prevalence. Among various treatment options, treatment by complementary and alternative medicines especially herbal remedies also practiced. Traditional Iranian medicine (TIM), a valuable resource of valid applied studies of ancient Iranian scholars, recommends numerous medicinal plants to treat dyspepsia symptoms. In this study, through investigation of TIM references, we aimed to identify medicinal plants for treatment of digestion insufficiency. Evidence Acquisition: In this qualitative study, dyspepsia symptoms including fullness, early satiety, bloating, nausea, and belching were checked under reliable sources of traditional medicine. Then medicinal plants recommended for the treatment of the symptoms were extracted from the books. Likewise, for investigating the pharmacological properties of medicinal plants used for the relieving of dyspepsia symptoms, electronic databases such as PubMed, Scopus, Google Scholar and some Iranian databases like SID and IranMedex were employed. Results: The study yielded 105 plants from 37 families which could treat various dyspepsia symptoms; fifty-seven plants, mainly from Apiaceae, Lamiaceae, Amaryllidaceae and Zingiberaceae had digestive effects. In this research, based on the information in TIM reference texts, we obtained 58 plants effective for bloating, 40 for nausea, 37 for appetite loss and 7 for belching. In human clinical trials conducted on medicinal plants effective for FD symptoms, 7 single plants were used. Conclusions: Finding the medicinal plants effective on digestion insufficiency based on TIM could suggest a better strategy for the relieving of dyspepsia symptoms. Traditional Iranian medicine prescribes medicinal plants based on each patient’s personal characteristics and practices multiple target therapies. PMID:26734483

  12. Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis.

    LENUS (Irish Health Repository)

    Keohane, John

    2012-02-03

    Functional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process. The pathophysiology of FD remains unclear but several theories have been proposed including visceral hypersensitivity, gastric motor dysfunction, Helicobacter pylori infection and psychosocial factors. In this review, we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD.

  13. Functional dyspepsia: The role of visceral hypersensitivity in its pathogenesis

    Institute of Scientific and Technical Information of China (English)

    John Keohane; Eamonn M M Quigley

    2006-01-01

    Functional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists.It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process.The pathophysiology of FD remains unclear but several theories have been proposed including visceral hypersensitivity, gastric motor dysfunction, Helicobacter pylori infection and psychosocial factors. In this review,we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD.

  14. Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis.

    Science.gov (United States)

    Keohane, John; Quigley, Eamonn M M

    2006-05-01

    Functional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process. The pathophysiology of FD remains unclear but several theories have been proposed including visceral hypersensitivity, gastric motor dysfunction, Helicobacter pylori infection and psychosocial factors. In this review, we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD.

  15. Pain and dyspepsia after elective and acute cholecystectomy

    DEFF Research Database (Denmark)

    Middelfart, H V; Kristensen, J U; Laursen, C N

    1998-01-01

    . Complaints of abdominal pain and dyspepsia were found with similar frequencies in the acute cholecystitis and gallstone groups. Women had abdominal pain more often than men (42% versus 29%) (P = 0.01). Although more than one-third complained of abdominal pain after cholecystectomy, 93% had improved or were...

  16. Dyspepsia: When and How to Test for Helicobacter pylori Infection

    Science.gov (United States)

    Bassotti, Gabrio; Usai-Satta, Paolo

    2016-01-01

    Dyspepsia is defined as symptoms related to the upper gastrointestinal tract. Approximately 25% of western populations complain of dyspeptic symptoms each year. 70% of them do not have an organic cause and symptoms are related to the so-called functional dyspepsia, characterized by epigastric pain, early satiety, and/or fullness during or after a meal occurring at least weekly and for at least 6 months according to ROME III criteria. In order to avoid invasive procedures and adverse effects, to minimize costs, to speed up diagnosis, and to provide the most appropriate treatments, primary care physicians need to recognize functional dyspepsia. Because symptoms do not reliably discriminate between organic and functional forms of the disease, anamnesis, family history of peptic ulcer and/or of gastric cancer, medication history, especially for nonsteroidal anti-inflammatory drugs, age, and physical examination could help the physician in discerning between functional dyspepsia and organic causes. For patients without alarm symptoms, noninvasive testing for H. pylori, with either carbon-13-labeled urea breath testing or stool antigen testing, is recommended as a first-line strategy. In this review, we provide recommendations to guide primary care physicians for appropriate use of diagnostic tests and for H. pylori management in dyspeptic patients. PMID:27239194

  17. Exploration of Dyspepsia%伤食探微

    Institute of Scientific and Technical Information of China (English)

    刘建材; 梁超

    2013-01-01

    目的:探讨伤食的病因病机及证治方药.方法:通过查阅古今文献并结合个人体会对伤食的相关内容进行分析,归纳总结其病因病机及证治方药.结果:伤食并不局限于小儿,其病因为饮食失常、脾胃本虚等,临床表现错综复杂,辨证当谨守病机,治疗以消导为主,重视脾胃,随症加减.结论:伤食的诊治当知常达变,圆机活法.%Objective:To summarize the causes and pathogenesisa and the TCM syndrome and treatment of dyspepsia. Methods:Though referring to the ancient and modern literature and combination of personal experience analysis of the related content of dyspepsia, summarize of its pathogenesis and treatment. Results: Dyspepsia is not confined to children, the cause is eating disorders, loss of virtual etc. ,clinical manifestations of perplexing, syndrome differentiation and disease of machine, treament to eliminate,pay attention to the spleen and stomach,addition and subtraction with the disease. Conclusion: Dyspepsia treatment when often known to chang,life circle machine.

  18. Dyspepsia: When and How to Test for Helicobacter pylori Infection

    Directory of Open Access Journals (Sweden)

    Maria Pina Dore

    2016-01-01

    Full Text Available Dyspepsia is defined as symptoms related to the upper gastrointestinal tract. Approximately 25% of western populations complain of dyspeptic symptoms each year. 70% of them do not have an organic cause and symptoms are related to the so-called functional dyspepsia, characterized by epigastric pain, early satiety, and/or fullness during or after a meal occurring at least weekly and for at least 6 months according to ROME III criteria. In order to avoid invasive procedures and adverse effects, to minimize costs, to speed up diagnosis, and to provide the most appropriate treatments, primary care physicians need to recognize functional dyspepsia. Because symptoms do not reliably discriminate between organic and functional forms of the disease, anamnesis, family history of peptic ulcer and/or of gastric cancer, medication history, especially for nonsteroidal anti-inflammatory drugs, age, and physical examination could help the physician in discerning between functional dyspepsia and organic causes. For patients without alarm symptoms, noninvasive testing for H. pylori, with either carbon-13-labeled urea breath testing or stool antigen testing, is recommended as a first-line strategy. In this review, we provide recommendations to guide primary care physicians for appropriate use of diagnostic tests and for H. pylori management in dyspeptic patients.

  19. Role of cholecystokinin and central serotonergic receptors in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Andrew Seng Boon Chua; PWN Keeling; TG Dinan

    2006-01-01

    Symptoms of functional dyspepsia are characterized by upper abdominal discomfort or pain, early satiety, postprandial fullness, bloating, nausea and vomiting. It is a chronic disorder, with symptoms more than 3 mo per year, and no evidence of organic diseases. Dysfunctional motility, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. It is believed that these pathophysiological mechanisms interact to produce the observed symptoms.Dyspepsia has been categorized into three subgroups based on dominant symptoms. Dysmotility-like dyspepsia describes a subgroup of patients whose symptom complex is usually related to a gastric sensorimotor dysfunction. The brain-gut peptide cholecystokinin (CCK)and serotonin (5-HT) share certain physiological effects.Both have been shown to decrease gastric emptying and affect satiety. Furthermore the CCK induced anorexia depended on serotonergic functions probably acting via central pathways. We believe that abnormalities of central serotonergic receptors functioning together with a hyper responsiveness to CCK or their interactions may be responsible for the genesis of symptoms in functional dyspepsia (FD).

  20. Quality of life in South East Asian patients who consult for dyspepsia: Validation of the short form Nepean Dyspepsia Index

    Directory of Open Access Journals (Sweden)

    Goh Khean-Lee

    2009-05-01

    Full Text Available Abstract Background Treatment objectives for dyspepsia include improvements in both symptoms and health-related quality of life (HRQoL. There is a lack of disease-specific instruments measuring HRQoL in South East Asian dyspeptics. Objectives To validate English and locally translated version of the Short-Form Nepean Dyspepsia Index (SF-NDI in Malaysian patients who consult for dyspepsia. Methods The English version of the SF-NDI was culturally adapted locally and a Malay translation was developed using standard procedures. English and Malay versions of the SF-NDI were assessed against the SF-36 and the Leeds Dyspepsia Questionnaire (LDQ, examining internal consistency, test-retest reliability and construct validity. Results Pilot testing of the translated Malay and original English versions of the SF-NDI in twenty subjects did not identify any cross-cultural adaptation problems. 143 patients (86 English-speaking and 57 Malay speaking with dyspepsia were interviewed and the overall response rate was 100% with nil missing data. The median total SF-NDI score for both languages were 72.5 and 60.0 respectively. Test-retest reliability was good with intraclass correlation coefficients of 0.90 (English and 0.83 (Malay, while internal consistency of SF-NDI subscales revealed α values ranging from 0.83 – 0.88 (English and 0.83 – 0.90 (Malay. In both languages, SF-NDI sub-scales and total score demonstrated lower values in patients with more severe symptoms and in patients with functional vs organic dyspepsia (known groups validity, although these were less marked in the Malay language version. There was moderate to good correlation (r = 0.3 – 0.6 between all SF-NDI sub-scales and various domains of the SF-36 (convergent validity. Conclusion This study demonstrates that both English and Malay versions of the SF-NDI are reliable and probably valid instruments for measuring HRQoL in Malaysian patients with dyspepsia.

  1. ACUPUNCTURE EFFECTIVENESS AS A COMPLEMENTARY THERAPY IN FUNCTIONAL DYSPEPSIA PATIENTS

    Directory of Open Access Journals (Sweden)

    Flavia Altaf da Rocha LIMA

    2013-09-01

    Full Text Available Context Functional dyspepsia represents a frequent gastrointestinal disorder in clinical practice. According to the Roma III criteria, functional dyspepsia can be classified into two types as the predominant sympton: epigastric pain and postprandial discomfort. Even though the pathophysiology is still uncertain, the functional dyspepsia seems to be related to multiple mechanisms, among them visceral hypersensitivity, changes in the gastroduodenal motility and gastric accommodation and psychological factors. Objective Evaluate the effectiveness of acupuncture as a complementary to conventional treatment in functional dyspepsia patients. Methods Randomized clinical trial in which were enrolled patients with functional dyspepsia patients in according with Rome III criteria. One group was submitted to drug therapy and specific acupuncture (GI and the other to drug therapy and non-specific acupuncture (GII. The gastrointestinal symptoms, presence of psychiatric disorders and quality of life were evaluated, at the end and three months after treatment. Results After 4 weeks of treatment there was improvement of gastrointestinal symptoms in Group I (55 ± 12 vs 29 ± 8.8; P = 0.001 and Group II (50.5 ± 10.2 vs 46 ± 10.5; P = 0.001. Quality of life was significantly better in Group I than group II (93.4 ± 7.3 vs 102.4 ± 5.1; P = 0.001. Anxiety (93.3% vs 0%; P = 0.001 and depression (46.7% vs 0%; P = 0.004 were significantly lower in Group I than group II. When comparing the two groups after 4 weeks of treatment, gastrointestinal symptoms (29 ± 8.8 vs 46 ± 10.5; P<0.001 and quality of life (102.4 ± 5.1 vs 96 ± 6.1; P = 0.021 were significantly better in Group I than group II. Three months after the treatment, gastrointestinal symptoms remained better only in Group I, when compared to the pre-treatment values (38 ± 11.3 vs 55 ± 12; P = 0.001. Conclusion In patients with functional dyspepsia the complementary acupuncture treatment is superior to

  2. ENDOSCOPIC EVALUATION OF PATIENTS WITH DYSPEPSIA IN A TERTIARY CARE HOSPITAL: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Samir Ranjan

    2016-05-01

    Full Text Available BACKGROUND Dyspepsia is a common presentation among the individuals attending the medical or surgical outpatient department to the general hospitals. The dietary habits, food pattern, socioeconomic status made the symptoms of dyspepsia more prevalent in rural and semi-urban areas. MATERIALS AND METHODS The prospective study was conducted at a general hospital for the patients with complaints of dyspepsia. RESULTS Epigastric discomfort and the postprandial fullness are the common symptoms of dyspepsia. The spicy food, smoking and habits of alcohol intake are the important causes of dyspepsia. CONCLUSION The patient with dyspepsia who are older than 50 years of age and/or those with alarm features should undergo endoscopic evaluation

  3. Colloidal bismuth subcitrate in non-ulcer dyspepsia.

    Directory of Open Access Journals (Sweden)

    Khanna M

    1992-07-01

    Full Text Available The effect of colloidal bismuth subcitrate (De-Nol on symptoms, Helicobacter pylori status and histological features was studied in 35 patients with non-ulcer dyspepsia. Pain (34 cases and gas bloat (18 were the predominant symptoms. H pylori was present in 26 (74.3% patients. Gastritis and duodenitis were present in 29 of 32 and 22 of 31 cases respectively in whom biopsies were available. Relief in symptoms after treatment was seen in 29 (82.8% cases. Improvement in gastritis and duodenitis was noted in 60.8% and 58.8% respectively; over 70% of H pylori positive patients cleared the organism. These changes did not correlate with the relief in symptoms. We conclude that colloidal bismuth subcitrate is effective in the short term treatment of non-ulcer dyspepsia. It also clears H pylori infection and results in improvement of histological features.

  4. Pain and dyspepsia after elective and acute cholecystectomy

    DEFF Research Database (Denmark)

    Middelfart, H V; Kristensen, J U; Laursen, C N;

    1998-01-01

    and dyspepsia 5-10 years after cholecystectomy in 345 (222 women, 123 men) patients cholecystectomized for acute cholecystitis and in a control group of 296 (213 women, 83 men) patients cholecystectomized for uncomplicated symptomatic gallbladder stones. RESULTS: Of 641 questionnaires, 534 (83%) were completed....... Complaints of abdominal pain and dyspepsia were found with similar frequencies in the acute cholecystitis and gallstone groups. Women had abdominal pain more often than men (42% versus 29%) (P = 0.01). Although more than one-third complained of abdominal pain after cholecystectomy, 93% had improved or were...... cured. CONCLUSION: The outcome after cholecystectomy seems to be independent of the underlying gallbladder disease (acute cholecystitis or elective operations for gallstones)....

  5. PREVALENCE OF HELICOBACTER PYLORI INFECTION IN PATIENTS WITH DYSPEPSIA

    Directory of Open Access Journals (Sweden)

    Chandrashekar

    2015-08-01

    Full Text Available Dyspepsia is synonymous with commonly used non - medical term indigestion . It includes symptoms like pain , bloating , nausea & early satiety . I t is now recognized that the large majority of duodenal and gastric ulcers are caused by H. pylori infection and/or NSAID use . H. pylori infection is associated with poverty, household crowding & limited education. Colonization rates exceed 70% in some groups and vary from less than 10% to more than 80% worldwide. Several studies have revealed the association of H. pylori in 70 – 75% of patients with dyspepsia. The aim o f this study is t o study the prevalence of H. pylori infection in dyspeptic patients. To study the various upper GI endoscopy findings in dyspeptic patients.

  6. High degree of duodenal inflammation in Nigerians with functional dyspepsia

    Directory of Open Access Journals (Sweden)

    Nwokediuko SC

    2013-12-01

    Full Text Available Sylvester Chuks Nwokediuko,1 Uchenna N Ijoma,1 Olive Obienu,1 Gideon E Anigbo,1 Okechukwu Okafor21Department of Medicine, 2Department of Morbid Anatomy, University of Nigeria Teaching Hospital, Ituku/Ozalla Enugu, NigeriaBackground: Functional dyspepsia (FD is a heterogeneous disorder associated with diverse pathophysiological mechanisms, including immune activation and low-grade mucosal inflammation. Genetic factors, physiological functions, and environmental factors may determine the relative importance of various pathophysiological mechanisms. This study was designed to determine the histological alterations in the duodenal mucosa of Nigerian patients with FD.Methods: Consecutive patients with dyspepsia seen over a 27-month period in two gastrointestinal endoscopy facilities in Enugu, South-East Nigeria were further evaluated with upper gastrointestinal endoscopy and duodenal mucosal biopsies if no lesion was found in the upper gastrointestinal tract. Patients with heartburn and/or regurgitation who did not have any dyspeptic symptoms and did not have any lesion in the upper gastrointestinal tract on endoscopy were presumed to have non-erosive reflux disease (NERD and they served as controls. The control subjects also had duodenal biopsies. The histopathological findings in the cases and controls were compared.Results: There were 68 patients with FD and 52 patients with NERD. The total inflammatory score was 242 in FD and 66 in NERD (Mann-Whitney U =1168, P=0.0011. Similarly, the scores for chronic inflammation, gastric metaplasia, neutrophilic activity, eosinophilic infiltration, and Helicobacter pylori were significantly higher in FD than NERD.Conclusion: Functional dyspepsia is associated with a high degree of inflammation in the duodenal mucosa. This may reflect the high prevalence of gastrointestinal infections in a tropical environment such as Nigeria. These findings may have therapeutic potential that further studies might elucidate

  7. The validity of a symptom diary in ratings of dyspepsia measured against a detailed interview

    DEFF Research Database (Denmark)

    Madsen, L G; Hansen, Jane Møller; Grønvold, M

    2007-01-01

    BACKGROUND: Patients' self-assessment of symptoms is central in drug treatment trials of functional dyspepsia. The validity of such ratings is important. AIM: To validate a diary for monitoring severity and duration of dyspepsia. METHOD: We compared the diary-cards with two clinicians' ratings of...

  8. Helicobacter pylori infection and dyspepsia in primary care : studies on diagnosis and guideline implementation

    NARCIS (Netherlands)

    Weijnen, Catherine Friderieke

    2002-01-01

    In this thesis various studies on the management of patients presenting with dyspepsia in primary care are described. Of all patients presenting with dyspepsia, only a minority has organic disease. Roughly 25% of the dyspeptic patients presenting in primary care is referred for endoscopy. At endosco

  9. Helicobacter pylori infection and dyspepsia in primary care : studies on diagnosis and guideline implementation

    NARCIS (Netherlands)

    Weijnen, Catherine Friderieke

    2002-01-01

    In this thesis various studies on the management of patients presenting with dyspepsia in primary care are described. Of all patients presenting with dyspepsia, only a minority has organic disease. Roughly 25% of the dyspeptic patients presenting in primary care is referred for endoscopy. At

  10. The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients

    Directory of Open Access Journals (Sweden)

    Wang-Ping Meng

    2016-01-01

    Full Text Available Helicobacter pylori (H. pylori, Hp colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori infection and various extragastric diseases. Functional dyspepsia (FD is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive H. pylori strains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positive H. pylori strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects of H. pylori and hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia.

  11. Pain and dyspepsia after elective and acute cholecystectomy

    DEFF Research Database (Denmark)

    Middelfart, H V; Kristensen, J U; Laursen, C N;

    1998-01-01

    BACKGROUND: Postcholecystectomy pain occurs in 20-30%. The main cause of this pain remains unclear. Whether the underlying gallbladder disease influences the outcome after cholecystectomy is not fully established. METHODS: A multicenter questionnaire study comparing the occurrence of abdominal pain....... Complaints of abdominal pain and dyspepsia were found with similar frequencies in the acute cholecystitis and gallstone groups. Women had abdominal pain more often than men (42% versus 29%) (P = 0.01). Although more than one-third complained of abdominal pain after cholecystectomy, 93% had improved or were...

  12. Clinical and epidemiological perspectives of dyspepsia in a multiracial Malaysian population.

    Science.gov (United States)

    Goh, Khean-Lee

    2011-04-01

    Dyspepsia is perhaps the most common gastrointestinal disease universally. The prevalence of dyspepsia ranges from 7-40% in population based studies worldwide. These figures vary with definition of dyspepsia used and also with the survey methodology. As with Western studies, functional dyspepsia (FD) predominates in Asia. With a decline in peptic ulcer disease and gastric cancer, the proportion of FD is set to increase further. Studies have shown FD to account for 50-70% of cases of uninvestigated dyspepsia. In Malaysia dyspepsia has been reported in up to 15% of a rural and 25% of an urban population. No racial differences were seen in the rural survey. In the urban survey, Malays and Indians were found to have significantly more dyspepsia than Chinese. No clear explanation can be found for these racial differences. In clinical practice, Malays seem to complain a lot of wind and bloating in the "stomach." This is interesting to note when you compare it with the prevalence of H. pylori which is distinctly less common amongst Malays compared to the Indians and Chinese. As with many Asian populations, many Malaysians do not consult for complains of dyspepsia. Many will self medicate and others may even bear with their complains. This is probably true in the rural population. Traditional medications are often used and these are often ethnic based. Different types of lotions for example are used for massaging the putative area in the abdomen by Malay, Chinese and Indian patients. Moxibustion and acupuncture is still practiced by Chinese traditional physicians for treatment of dyspepsia. The notion that mood disorders may underlies dyspepsia is still poorly accepted by a less educated or rural population who consider a psychiatric consultation a taboo. Amongst urban dwellers where Westernized medical care is readily available and the awareness of potential serious disease like cancer is higher, consultation for dyspepsia is certainly higher. Indeed a higher education

  13. Functional dyspepsia: A new approach from traditional Persian medicine

    Directory of Open Access Journals (Sweden)

    Mehdi Pasalar

    2016-03-01

    Full Text Available Objective: One of the most common global disorders is related to gastrointestinal system. Functional dyspepsia (FD defined as upper abdominal pain and discomfort in the absence of organic ailments is a prevalent disease without any confirmed medication. The purpose of this study was to find gastric disorders which might be coincidental to FD based on traditional Persian medicine (TPM. Materials and Methods: We searched the main textbooks of TPM including Al-Havi (by Rhazes, Canon of medicine (by Avicenna, ZakhireKhawrazmshahi (by Ismail Jorjani, Moalijat-e Aghili and Makhzan Al-adviya (by Mohammad Hosein AghiliShirazi, and ExirAzam (by Hakim Azam Khan. Also, we searched Pubmed, Scopus, Science Direct, Medline, scientific information database (SID, Iranmedex and Google Scholar from 1980 to 1 August 2014 for dyspepsia, gastrointestinal disease, traditional Persian medicine, and gastric dystemperaments. Results: There is no equivalent term for FD in traditional Persian medicine although similar signs and symptoms are visible in terms like simple cold dystemperament of stomach, indigestion, and digestion debility in TPM sources. Some treatments mentioned in TPM have shown promising results in the current experimental tests. Conclusion: Finding these similarities in complementary and alternative medicine (CAM textbooks may lead to discovering new remedies for this widespread disease.

  14. Functional dyspepsia: A new approach from traditional Persian medicine.

    Science.gov (United States)

    Pasalar, Mehdi; Nimrouzi, Majid; Choopani, Rasool; Mosaddegh, Mahmoud; Kamalinejad, Mohammad; Mohagheghzadeh, Abdolali; Bagheri Lankarani, Kamran

    2016-01-01

    One of the most common global disorders is related to gastrointestinal system. Functional dyspepsia (FD) defined as upper abdominal pain and discomfort in the absence of organic ailments is a prevalent disease without any confirmed medication. The purpose of this study was to find gastric disorders which might be coincidental to FD based on traditional Persian medicine (TPM). We searched the main textbooks of TPM including Al-Havi (by Rhazes), Canon of medicine (by Avicenna), ZakhireKhawrazmshahi (by Ismail Jorjani), Moalijat-e Aghili and Makhzan Al-adviya (by Mohammad Hosein AghiliShirazi), and ExirAzam (by Hakim Azam Khan). Also, we searched Pubmed, Scopus, Science Direct, Medline, scientific information database (SID), Iranmedex and Google Scholar from 1980 to 1 August 2014 for dyspepsia, gastrointestinal disease, traditional Persian medicine, and gastric dystemperaments. There is no equivalent term for FD in traditional Persian medicine although similar signs and symptoms are visible in terms like simple cold dystemperament of stomach, indigestion, and digestion debility in TPM sources. Some treatments mentioned in TPM have shown promising results in the current experimental tests. Finding these similarities in complementary and alternative medicine (CAM) textbooks may lead to discovering new remedies for this widespread disease.

  15. Integrative Treatment of Reflux and Functional Dyspepsia in Children

    Directory of Open Access Journals (Sweden)

    Ann Ming Yeh

    2014-08-01

    Full Text Available Gastroesophageal reflux disease (GERD and functional dyspepsia (FD are common problems in the pediatric population, with up to 7% of school-age children and up to 8% of adolescents suffering from epigastric pain, heartburn, and regurgitation. Reflux is defined as the passage of stomach contents into the esophagus, while GERD refers to reflux symptoms that are associated with symptoms or complications—such as pain, asthma, aspiration pneumonia, or chronic cough. FD, as defined by the Rome III classification, is a persistent upper abdominal pain or discomfort, not related to bowel movements, and without any organic cause, that is present for at least two months prior to diagnosis. Endoscopic examination is typically negative in FD, whereas patients with GERD may have evidence of esophagitis or gastritis either grossly or microscopically. Up to 70% of children with dyspepsia exhibit delayed gastric emptying. Treatment of GERD and FD requires an integrative approach that may include pharmacologic therapy, treating concurrent constipation, botanicals, mind body techniques, improving sleep hygiene, increasing physical activity, and traditional Chinese medicine and acupuncture.

  16. Systematic Approach toward the Clinical Diagnosis of Functional Dyspepsia

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    Pierre Paré

    1999-01-01

    Full Text Available Functional dyspepsia (FD is the most common condition in patients consulting with upper gastrointestinal tract symptoms, resulting in up to 5% of visits to family physicians. By definition, patients with FD have no clinical, biochemical or endoscopic evidence of an organic disease that is likely to explain their symptoms. The process to be used in a structured interview for establishing a clinical diagnosis of FD is presented. The steps are as follows: determine the duration and the course of the disease; characterize the current syndrome and review the alarm symptoms; elicit the patient-perceived dominant symptom and/or condition; and identify the patient’s reason for consulting and address the psychosocial factors. According to the clinical characteristics of the three most frequent causes of dyspepsia (peptic ulcer, gastroesophageal reflux and FD and acknowledging that these conditions may coexist rather than overlap in some patients, an algorithm is suggested for establishing a working diagnosis of FD and indications for investigation, and initiating a management strategy.

  17. Rate and yield of repeat upper endoscopy in patients with dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Uri; Ladabaum; Viam; Dinh

    2010-01-01

    AIM: To determine the rate and yield of repeat esophagogastroduodenoscopy (EGD) for dyspepsia in clinical practice,whether second opinions drive its use,and whether it is performed at the expense of colorectal cancer screening.METHODS: We performed a retrospective cohort study of all patients who underwent repeat EGD for dyspepsia from 1996 to 2006 at the University of California,San Francisco endoscopy service.RESULTS: Of 24 780 EGDs,5460 (22%) were performed for dyspepsia in 4873 patients.Of these,451 pat...

  18. Functional dyspepsia of ulcer-dysmotility type: clinical incidence and therapeutic strategy

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    @@ Functional dyspepsia is a commonly occurring chronic digestive disorder affecting 20%-40% of the general population[1]. It is a syndromic term applied to patients who complain of symptoms presumably arising from the upper abdomen, often in response to meal ingestion, but with absence of organic abnormalities demonstrable by conventional diagnostic tests. Although functional dyspepsia is very common in the community, the classification and the clinical therapy are still uncertain. Therefore this study deals with the clinical incidence and the therapeutic strategy of functional dyspepsia of the ulcer-dysmotility mixed type.

  19. Management of New Symptoms of Dyspepsia in the Elderly in Quebec

    Directory of Open Access Journals (Sweden)

    Jacques LeLorier

    1997-01-01

    Full Text Available OBJECTIVE: To use the Régie de l'assurance-maladie du Québec (RAMQ database to study the clinical strategies used by Quebec physicians in the management of dyspepsia in the elderly.

  20. Clinical Efficacy of Proton Pump Inhibitor versus Prompt Endoscopy for Management of People with Dyspepsia

    DEFF Research Database (Denmark)

    Kjeldsen, Hans Christian; Lauritzen, Torsten; Christensen, Bo

      Title:   Clinical Efficacy of Proton Pump Inhibitor versus Prompt Endoscopy for Management of People with Dyspepsia: A Randomized Clinical Trial in General Practice.     Purpose: To compare the clinical efficacy of two strategies for management of dyspepsia in general practice in a RCT design.......   Setting: June 2000 to August 2002, 41 GPs, Aarhus County, Denmark   Methods: 368 people with dyspepsia (epigastric pain/discomfort, no alarm symptoms) were randomly assigned to treatment with omeprazol 40 mg/day for two weeks (PPI group, n:185) or endoscopy (endoscopy group, n:183). Due to migration......, dyspeptic contacts to GP or patients' satisfaction. Conclusions: Prompt endoscopy was superior to proton pump inhibitor concerning symptom improvement in management of dyspepsia in general practice when pain/discomfort was the primary symptom. There were no differences between the two strategies in respect...

  1. Which patient-related factors determine self-perceived patient adherence to prescribed dyspepsia medication?

    NARCIS (Netherlands)

    Fransen, G.A.J.; Mesters, I.; Janssen, M.J.R.; Knottnerus, J.A.; Muris, J.W.M.

    2009-01-01

    Patient adherence to medical treatment for dyspepsia is disappointing, whereas adherence is crucial for a proper evaluation of treatment. This prospective study used elements of the Integrated Change Model and Weiner's Attribution Theory to describe patients' important cognitions and their

  2. Editorial: Reflux, dyspepsia, and Rome III (or Rome IV?).

    Science.gov (United States)

    Stanghellini, Vincenzo; Frisoni, Chiara

    2010-12-01

    The paper by Xiao et al. in this issue of American Journal of Gastroenterology reports that patients with functional dyspepsia (FD) complaining of epigastric burning have a higher probability to present abnormal gastroesophageal acid reflux, as well as response to proton pump inhibitor therapy than those complaining of epigastric pain, bothersome postprandial fullness, or early satiety. No differences in the above parameters were detected when comparing patients with epigastric pain syndrome and postprandial distress syndrome, as proposed by the Rome III classification of FD. If confirmed, these results contribute to clarify the relationship between FD and gastroesophageal reflux disease and, at the same time, highlight the importance of analyzing individual symptoms rather than clusters of symptoms, when managing patients complaining of upper gastrointestinal symptoms.

  3. Rome III functional dyspepsia symptoms classification: Severity vs frequency.

    Science.gov (United States)

    Carbone, F; Holvoet, L; Vanuytsel, T; Tack, J

    2017-06-01

    The Rome III criteria subdivide functional dyspepsia (FD) in the epigastric pain syndrome (EPS) and the postprandial distress syndrome (PDS) based on the frequency of the symptoms to optimize the diagnostic and therapeutic approach. However, it is unclear to which extent the frequency of the symptoms is related to their severity. Our aim was to explore the frequency and severity of dyspeptic symptoms and their relationship in FD patients. Functional dyspepsia patients fulfilling the Rome III diagnostic completed a questionnaire that evaluated the frequency and severity of FD symptoms. The concordance between the severity and frequency categories was analyzed by means of spearman correlation and the concordance correlation coefficient (ρc ). In the entire patient cohort (n=421), the classification of symptoms severity and frequency showed good concordance for all symptoms. In the EPS subgroup (n=….), the symptom severity and frequency score of epigastric pain showed a poor correlation (r=.28; ρc =0.07). The PDS subgroup (n=…) showed a good correlation for most of the symptoms. Due to its limited occurrence in this group, the correlation of the severity and frequency scores for epigastric pain is of little relevance (r=.79; ρc =0.58). The overlap EPS-PDS group showed good correlation for most of the symptoms, except for epigastric pain (pain r=.24; ρc =0.09). We conclude that the information given by the assessment of frequency and severity of PDS symptoms is comparable and hence one of the scores sufficiently identifies symptom pattern in PDS patients. In EPS patients, both the symptom frequency and severity should be taken into account as two separate entities. © 2017 John Wiley & Sons Ltd.

  4. Itopride therapy for functional dyspepsia: A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Xuan Huang; Bin Lv; Shuo Zhang; Yi-Hong Fan; Li-Na Meng

    2012-01-01

    AIM:To evaluate the therapeutic effects of itopride vs other drugs (placebo,domperidone,mosapride) for functional dyspepsia (FD).METHODS:Randomized controlled trials (RCTs) of itopride for FD were retrieved from databases.Relevant information was extracted and analyzed,using the relative risk (RR) and weighted mean deviation,as appropriate.A random or fixed effect model was used,based on the heterogeneity of the included articles,and visual inspection of funnel plots was used to evaluate publication bias.RESULTS:Nine RCTs enrolling 2620 FD cases were included; 1372 cases received itopride treatment and 1248 cases received placebo or other drugs (control groups).Compared with control groups,itopride had superior RR values of 1.11 [95%CI:(1.03,1.19),P =0.006],1.21 [95%CI:(1.03,1.44),P =0.02],and 1.24 [95%CI:(1.01,1.53),P =0.04] for global patient assessment,postprandial fullness,and early satiety,respectively.For the Leeds Dyspepsia Questionnaire score,the weighted mean deviation was-1.38 [95%CI:(-1.75,-1.01),P < 0.01].The incidence of adverse effects was similar in the itopride and control groups.The funnel plots for all indicators showed no evidence of publication bias.CONCLUSION:Itopride has good efficacy in terms of global patients assessment,postprandial fullness,and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions.Itopride can greatly improve FD syndromes-score.

  5. Helicobacter pylori related dyspepsia: prevalence and treatment outcomes at University Kebangsaan Malaysia-Primary Care Centre

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    Abdul Aziz Aznida

    2009-05-01

    Full Text Available Abstract Background Optimum management of dyspepsia in primary care is a debatable subject. Testing for Helicobacter pylori (HP has been recommended in primary care as this strategy will cure most underlying peptic ulcer disease and prevent future gastro duodenal disease. Methods A total of 98 patients completed Modified Glasgow Dyspepsia Severity Score Questionnaire (MGDSSQ at initial presentation before undergoing the 13Carbon Urea Breath Test (UBT for HP. Those with positive UBT received Eradication Therapy with oral Omeprazole 20 mg twice daily, Clarithromycin 500 mg daily and Amoxycillin 500 mg twice daily for one week followed by Omeprazole to be completed for another 4 to 6 weeks. Those with negative UBT received empirical treatment with oral Omeprazole 20 mg twice daily for 4 to 6 weeks. Patients were assessed again using the MGDSSQ at the completion of treatment and one month after stopping treatment. Results The prevalence of dyspepsia at Universiti Kebangsaan Malaysia-Primary Care Centre was 1.12% (124/11037, out of which 23.5% (23/98 was due to HP. Post treatment assessment in both HP (95.7%, 22/23 and non HP-related dyspepsia (86.7%, 65/75 groups showed complete or almost complete resolution of dyspepsia. Only about 4.3% (1/23 in the HP related dyspepsia and 13.3% (10/75 in the non HP group required endoscopy. Conclusion The prevalence of dyspepsia due to HP in this primary care centre was 23.5%. Detection of HP related dyspepsia yielded good treatment outcomes (95.7%.

  6. [Functional dyspepsia in students of eigth peruvians medical schools. Influence of the habits].

    Science.gov (United States)

    Vargas, Mariela; Talledo-Ulfe, Lincolth; Samaniego, Reimer O; Heredia, Paula; Rodríguez, Christian A S; Mogollón, César A; Enriquez, Walter F; Mejia, Christian R

    2016-06-01

    Functional dyspepsia impacts on quality of life. Due to its multifactorial etiology its characterization proves difficult, especially in populations at risk such as medical students. To determine if behavioral and harmful habits of medical students from eight universities of Peru were associated to functional dyspepsia. Multicentric, cross-sectional study. A self-administered questionnaire was taken among students enrolled in eight medical faculties in Peru. Functional dyspepsia was measured using a validated test; diet characteristics, alcohol, tobacco, coffee or energy drinks consumption were considered behavioral habits. Furthermore, others from the social and educational sphere were measured. Bivariate and multivariate statistical analyses were made. From a total of 1.923 students, the median of the ages was 20, 55% were women and 24% suffered from functional dyspepsia. Factors which diminished the frequency of functional dyspepsia were masculine gender (aPR:0,75; 95%CI:0.64-0.87; p students suffered from functional dyspepsia, this being related to several behavioral variables; therefore further studies as well as educational institutions’ intervention is required, due to the short and long term problems that may arise from this situation.

  7. Effect of herb drug medicine Treatment for Functional Dyspepsia:Controlled Trial

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    Lee Jae-Jin

    2009-06-01

    Full Text Available Obejective : Functional dyspepsia is a prevalent disease. It impedes subjective quality of life. The purpose of this research is to examine the equivalent effect of herb drug medicine treatment(H-Dand Over the Counter(OTC for functional dyspepsia. Method : In this controlled study, we compared herb drug medicine(H-D with Over the Counter(OTC of functional dyspepsia. 30 volunteers who satisfied the requirements were enrolled in study. Severity of dyspepsia was measured by Nepean Dyspepsia Index(NDI-K before and after treatments. Result : The results are summarized as follows. 1. In Herb drug medicine and Over the Counter groups, total key symptoms score of after treatment were significantly decreased and improve rate of key symptoms was higher than before treatment, but there were no statistical significance between two groups. 2. In Herb drug medicine and Over the Counter groups, each symptoms score of after treatment were significantly decreased and improve rate of key symptoms was higher than before treatment, but there were no statistical significance between two groups. 3. In Herb drug medicine and Over the Counter groups, quality of life score of after treatment were significantly decreased and improve rate of key symptoms was higher than before treatment, but there were no statistical significance between two groups. Conclusion : Herb drug medicine treatment(H-D is effective to improve the symptoms and quality of life in patients with functional dyspepsia.

  8. Celiac disease prevalence is not increased in patients with functional dyspepsia.

    Science.gov (United States)

    Lasa, Juan; Spallone, Liliana; Gandara, Silvina; Chaar, Elsa; Berman, Saul; Zagalsky, David

    2017-01-01

    - Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. - To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. - Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies. On the other hand, asymptomatic adult volunteers who performed a preventive visit to their primary care physician were invited to participate and agreed to undertake an upper gastrointestinal endoscopy with duodenal biopsies as well. Those patients with histologic signs of villous atrophy were furtherly evaluated and serological tests were performed in order to determine celiac disease diagnosis. Celiac disease prevalence was compared between groups. - Overall, 320 patients with dyspepsia and 320 healthy controls were recruited. There were no significant differences in terms of gender or age between groups. Celiac disease diagnosis was made in 1.25% (4/320) of patients in the dyspepsia group versus 0.62% (2/320) in the control group. - Patients with dyspepsia who underwent routine duodenal biopsies did not show an increased risk for celiac disease when compared to healthy individuals.

  9. The impact of dyspepsia on symptom severity and quality of life in adults with headache.

    Directory of Open Access Journals (Sweden)

    Mei-Ling Sharon Tai

    Full Text Available BACKGROUND: Dyspepsia and headache frequently co-exist, but the clinical implication of this association is uncertain. We planned to examine the prevalence and impact of dyspepsia in adults with headache. METHODS: A cross-sectional study was conducted in a secondary care setting. Clinical, psychological and health-related quality of life (HRQOL data were compared between subjects with headache and controls (non-headache subjects. The impact of dyspepsia was analysed further in subjects with headache alone. RESULTS: 280 subjects (93 cases with headache and 187 matched controls were recruited. The following baseline characteristics of subjects were as follows: mean age 45.0 ± 17.3 years, 57.0% females and ethnic distribution-Malaysian = 45 (48.4%, Chinese n = 24 (25.8% and Indians n = 24 (25.8%. Headache sub-types among cases with headache were as follows: tension-type headache (TTH n = 53 (57.0% and migraine n = 40 (43.0%. Dyspepsia was more prevalent in cases with headache compared to controls (25.8% vs 12.8%, p = 0.011, and headache was independently associated with dyspepsia (OR 2.75, 95% CI 1.39-5.43. Among cases with headache, there was a trend towards a higher prevalence of dyspepsia in those with migraine (27.5% compared to TTH (24.5%. Subjects with headache and dyspepsia, compared to those with headache alone, had a greater severity of headache symptoms (63.67 ± 22.85 mm vs 51.20 ± 24.0 mm VAS, p = 0.029. Overall HRQOL scores were lower in headache subjects with dyspepsia (EQ-5D summary score 0.82 ± 0.18 vs 0.90 ± 0.16, p = 0.037 and EQ-5D VAS 62.08 ± 17.50 mm vs 72.62 ± 18.85 mm, p = 0.018, compared to those without dyspepsia. CONCLUSION: Dyspepsia is associated with more severe headache symptoms and results in a lower HRQOL in patients with headache.

  10. Acupuncture for Functional Dyspepsia: A Single Blinded, Randomized, Controlled Trial

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    Yulian Jin

    2015-01-01

    Full Text Available In order to investigate the therapeutic potential of acupuncture on patients with functional dyspepsia (FD, patients were randomized to receive acupuncture at classic acupoints with manipulations (treatment group versus acupuncture at nonacupoints without manipulation (control group once every other day, three times a week, for one month and were followed up for three months. The primary outcomes included dyspeptic symptoms, quality of life, and mental status. The secondary outcomes included the fasting serum gastrin concentration, and frequency and propagation velocity of gastric slow waves. Sixty patients with FD were included, among whom, four dropped out. After one month's treatment, patients with FD showed significant improvements in primary (in both groups and secondary (in the eight patients of the treatment group outcomes as compared with baseline (P=0.0078 to <0.0001; treatment group has better outcomes in all primary outcome measures (P<0.0001 except for SDS (P=0.0005. Improvements on dyspeptic symptoms persist during follow-up (better in the treatment group. Acupuncture with manual manipulation had better effects on improving dyspeptic symptoms, mental status, and quality of life in patients with FD. These effects may be related to the increased frequency and propagation speed of gastric slow waves and serum gastrin secretion.

  11. Relationship between antral distension and postprandial symptoms in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Nadia Pallotta; Patrizio Pezzotti; Enrico Corazziari

    2006-01-01

    AIM: To investigate in patients with functional dyspepsia(FD) after an every-day meal whether (1) gastrointestinal (GI) and extra-GI symptoms had any relation with the degree of antral volume, (2) the onset of postprandial symptoms was associated with, and may predict, delayed gastric emptying.METHODS: In 94 symptomatic FD patients, antral volume variations and gastric emptying were assessed with ultrasonography after a 1050 kcal meal. Symptoms were evaluated with a standardized questionnaire. The association of GI and extra-GI symptoms with antral volumes and gastric emptying were estimated with logistic regression analysis.RESULTS: Forty percent of patients did not report any symptoms after a meal. Compared to the healthy controls, the antrum was more distended in patients throughout the entire observation period and 37 (39.4%)patients had delayed gastric emptying. Only postprandial drowsiness was associated with antral volume variations (AOR = 1.42; P < 0.001) and with delayed gastric emptying (AOR = 3.59; P < 0.03).CONCLUSION: In FD patients, GI symptoms are neither associated with antral distension nor with gastric emptying. Drowsiness is associated with antral distension and delayed gastric emptying. The onset of drowsiness is preceded by an increment of antral distension and the duration of the symptom appears to be related to the persistence of antral distension.

  12. Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria.

    Science.gov (United States)

    Tack, Jan; Talley, Nicholas J

    2013-03-01

    Dyspepsia refers to a heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur. Functional dyspepsia is defined as the presence of dyspeptic symptoms in the absence of an organic cause that readily explains them. The Rome III consensus proposed the subdivision of functional dyspepsia into postprandial distress syndrome (PDS), characterized by postprandial fullness and early satiation, and epigastric pain syndrome (EPS), characterized by epigastric pain or burning. Epidemiological studies in the USA and Europe confirmed the presence of both subgroups, with good separation between EPS and PDS. By contrast, other studies have found major overlap between EPS and PDS in patients with functional dyspepsia in specialist care centres in Europe and Asia. Preliminary pathophysiological studies suggest that PDS might be characterized by a higher prevalence of impaired gastric accommodation than EPS and raised duodenal eosinophil counts. Whether different treatment approaches are needed for EPS and PDS is currently unclear; only acotiamide, a new drug for the treatment of functional dyspepsia, has been found to be efficacious in PDS but not in EPS. Further randomized controlled trials testing treatment response by subgroup are urgently needed.

  13. Portuguese validation of the Rome III diagnostic questionnaire for functional dyspepsia

    Directory of Open Access Journals (Sweden)

    Pâmela Schitz Von Reisswitz

    2010-12-01

    Full Text Available CONTEXT: Validated questionnaires are essential tools to be utilized in epidemiological research. At the moment there are no Rome III diagnostic questionnaires translated to Portuguese. OBJECTIVE: To validate the Portuguese version of the Rome III Diagnostic Questionnaire for Functional Dyspepsia. METHODS: The questionnaire has been translated following the Rome III recommendations. Hundred and nine consecutive patients with functional dyspepsia answered the questionnaire. The control group comprised 100 healthy consecutive blood donors, without digestive problems. Internal consistency, reproducibility, responsiveness, discriminate validity and content analysis were evaluated. RESULTS: Cronbach's α coefficient was 0.92. The questionnaire showed reliability: the patients answered it in a similar way on two distinct occasions and their responses were substantially very similar (P = 1.00. The questionnaire was able to demonstrate changes when they occur (P<0.01. Two "blinded" gastroenterologists agreed that the questionnaire adequately evaluated Functional Dyspepsia. When we compared the answers between patients and controls, the questionnaire showed that 5.3% of controls had Functional Dyspepsia symptoms compared with 91.2% of the patients (P<0.01. CONCLUSION: The Rome III Diagnostic Questionnaire for Functional Dyspepsia is ready to be used in clinical researches in lusophone countries, as it has been successfully validated in Portuguese.

  14. Food intolerance, diet composition, and eating patterns in functional dyspepsia patients.

    Science.gov (United States)

    Carvalho, Roberta Villas Boas; Lorena, Sônia Letícia Silva; Almeida, Jazon Romilson de Souza; Mesquita, Maria Aparecida

    2010-01-01

    The aims of this study are to investigate dietary factors, food intolerance, and the body mass index data, as an indicator of nutritional status, in functional dyspepsia patients. Forty-one functional dyspepsia patients and 30 healthy volunteers answered a standardized questionnaire to identify eating habits and food intolerance, and then completed a 7-day alimentary diary. There was no significant difference in daily total caloric intake between patients and controls. Patients associated their symptoms with the ingestion of several foods, but in general maintained their regular intake, with the exception of a small reduction in the proportion of fat in comparison with controls (median 28 vs. 34%; P = 0.001). No patient was underweight. In conclusion, our results suggest that food intolerance has no remarkable influence on food pattern and nutritional status in most functional dyspepsia patients. Further studies are necessary to clarify the role of fat in the generation of dyspeptic symptoms.

  15. Thermal Care of Functional Dyspepsia Based on Bicarbonate-Sulphate-Calcium Water: A Sequential Clinical Trial

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    Giuseppe Rocca

    2007-01-01

    Full Text Available Drug treatment of functional dyspepsia is often unsatisfactory. We assessed the efficacy of a bicarbonate-sulphate-calcium thermal water cycle of 12 days, in patients with functional dyspepsia. Patients with functional dyspepsia were sent by their general practitioners to 12 days of treatment with thermal water, 200–400 ml in the morning, at temperature of 33°C (91.4 F and were evaluated on a strict intention to treat basis. Four efficacy endpoints were analyzed as follows: (i reduction of the global symptoms score, (ii reduction of intensity to a level not interfering with everyday activities, (iii specific efficacy on ulcer-like or dysmotility-like dyspepsia and (iv esophageal or abdominal-associated symptoms. Statistical significance was reached for all three primary outcomes after the first 29 consecutive patients. Thermal water reduced the global symptom score, reduced intensity of symptoms to a level not interfering with everyday activity, but was unable to completely suppress all symptoms. A parallel effect emerged for ulcer-like and dyspepsia-like subgroups. The effect on heartburn and abdominal symptoms was not significant, suggesting a specific effect of the water on the gastric and duodenal wall. The Roma II criteria identify a natural kind of dyspepsia that improves with thermal water. Ulcer-like and dysmotility-like are not therapeutically distinguishable subgroups. Patients with dominant esophageal or abdominal symptoms should receive a different therapy. Sequential methods are very effective for the evaluation of traditional care practices and should be considered preliminary and integrative to randomized controlled trials in this context.

  16. Thermal Care of Functional Dyspepsia Based on Bicarbonate-Sulphate-Calcium Water: A Sequential Clinical Trial

    Science.gov (United States)

    Dioni, Federico; Rocca, Nadia; Oliveri, Filippo; Brunetto, Maurizia R; Bonino, Ferruccio

    2007-01-01

    Drug treatment of functional dyspepsia is often unsatisfactory. We assessed the efficacy of a bicarbonate-sulphate-calcium thermal water cycle of 12 days, in patients with functional dyspepsia. Patients with functional dyspepsia were sent by their general practitioners to 12 days of treatment with thermal water, 200–400 ml in the morning, at temperature of 33°C (91.4 F) and were evaluated on a strict intention to treat basis. Four efficacy endpoints were analyzed as follows: (i) reduction of the global symptoms score, (ii) reduction of intensity to a level not interfering with everyday activities, (iii) specific efficacy on ulcer-like or dysmotility-like dyspepsia and (iv) esophageal or abdominal-associated symptoms. Statistical significance was reached for all three primary outcomes after the first 29 consecutive patients. Thermal water reduced the global symptom score, reduced intensity of symptoms to a level not interfering with everyday activity, but was unable to completely suppress all symptoms. A parallel effect emerged for ulcer-like and dyspepsia-like subgroups. The effect on heartburn and abdominal symptoms was not significant, suggesting a specific effect of the water on the gastric and duodenal wall. The Roma II criteria identify a natural kind of dyspepsia that improves with thermal water. Ulcer-like and dysmotility-like are not therapeutically distinguishable subgroups. Patients with dominant esophageal or abdominal symptoms should receive a different therapy. Sequential methods are very effective for the evaluation of traditional care practices and should be considered preliminary and integrative to randomized controlled trials in this context. PMID:17965771

  17. Prevalence of Helicobacter pylori infection in maintenance hemodialysis patients with non-ulcer dyspepsia.

    Science.gov (United States)

    Asl, Mohammad Kazem Hosseini; Nasri, Hamid

    2009-03-01

    The purpose of this prospective study is to determine the prevalence of Helico-bacter pylori (H. pylori) infection among stable chronic hemodialysis (HD) patients having non ulcer dyspepsia. The study was carried out on 80 patients consisting of 40 patients with dyspepsia and 40 consecutive control subjects without renal disease and dyspepsic symptoms. Mean age of patients were 56 +/- 14 and 47 +/- 15 respectively. This study showed no significant difference of H. pylori infection between the two groups. Tissue examination of gastric antrum showed higher localization of H. pylori in HD patients in contrast to controls. This finding has not been reported before and needs further confirmation and evaluation for its significance.

  18. [Brief analysis of professor YAN Jie's academic thought on functional dyspepsia treated with acupuncture and moxibustion].

    Science.gov (United States)

    Tan, Tao; Yan, Jie

    2016-01-01

    The brief discussion is introduced in the paper on the academic thought of professor YAN Jie, the contemporary famous TCM doctor, on functional dyspepsia treated with acupuncture and moxibustion. Treatment based on "the three-regional acupoint selection" is applied to professor YAN's treatment for functional dyspepsia, in which, acupuncture is on Sibai (ST 2), Liangmen (ST 21) and Zusanli (ST 36), and the supplementary points are added accordingly. The academic thought is described as the combination of acupuncture and moxibustion based on strengthening healthy qi, supplemented by soothing the liver and psychological counseling. Also, an example is provided.

  19. Functional dyspepsia and nonerosive reflux disease: clinical interactions and their implications.

    Science.gov (United States)

    Keohane, John; Quigley, Eamonn M M

    2007-08-08

    Functional dyspepsia or nonulcer dyspepsia, and nonerosive reflux disease (NERD) or endoscopy-negative reflux disease, are common reasons for referral to a gastroenterologist. Although there is much confusion with regard to definition, recent research would suggest that these 2 conditions are linked and may represent components in the spectrum of the same disease entity, in terms of both symptoms and pathophysiology. Several theories have been proposed regarding the etiology of these disorders, including acid exposure, visceral hypersensitivity, impaired fundal accommodation, delayed gastric emptying, and Helicobacter pylori infection.

  20. [Helicobacter pylori infection in patients with functional dyspepsia, eradication rates in the Donetsk region].

    Science.gov (United States)

    Dorofeev, A É; Rudenko, N N; Agibalov, A N; Kugler, T E; Sibilev, A V; Tomash, O V

    2014-11-01

    We have investigated 175 patients with Rome III diagnostic criteria for functional dyspepsia. 104 (59%) patients were infected with Helicobacter pylori. Three-component (PPI + clarithromycin + amoxicillin) 7-day therapy with the addition of the probiotic was effective in 92 patients (88.4%). Dyspeptic symptoms were resolved in 37 patients with successful eradication (40%). Persistent effect for 6 months was maintained in 24 patients (26%). Eradication efficacy in eliminating of the dyspepsia symptoms was higher in epigastric pain syndrome than postprandial distress syndrome.

  1. Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Gilles Gargala; Stéphana Lecleire; Arnaud Frangois; Serge Jacquot; Pierre Déchelotte; Jean Jacques Ballet; Loic Favennec; Philippe Ducrotté

    2007-01-01

    AIM:To quantify the intraepithelial lymphocytes (IELs) and to document the membrane expression of CD4,CD8,TCRγδ and adhesion and/or activation-associated molecules (CD103,CD28,CD44,CD69,HLA-DR,CD95/Fas) in the duodenal mucosa of patients with functional dyspepsia (FD) in order to provide arguments for an immunological process in FD.METHODS:Twenty-six FD patients according to Rome Ⅱ criteria (20 were H pylori negative) were studied and compared to 12 healthy adults.IELs were isolated from five duodenal biopsy samples,then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry.RESULTS:Duodenal histological examination was normal.In H pylori negative patients,the number of IELs was not different from that in healthy controls.Median percentage expression of CD4,CD8,or TCRγδ and CD103,CD44,CD28,CD69 on CD3+ IELs,among the adhesion/activation associated molecules tested,was not different from that in healthy controls.In contrast,the median percentage expression of CD95/Fas [22(9-65) vs 45(19-88),P=0.03] and HLADR expressing CD3+ IELs [4(0-30) vs 13(4-42),P=0.041 was signifcantly lower in the H pylori negative FD group than in healthy controls,respectively.The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratio for 100 enterocytes 27.5 (6.7-62.5) vs 10.8 (3-33.3), P = 0.02] due to a higher number of CD8+ CD3+ IELs.CONCLUSION: In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD.

  2. Management of functional dyspepsia: Unsolved problems and new perspectives

    Institute of Scientific and Technical Information of China (English)

    Ahmed Madisch; Stephan Miehlke; Joachim Labenz

    2005-01-01

    The common characteristic criteria of all functional gastrointestinal(GI)disorders are the persistence and recurrence of variable gastrointestinal symptoms that cannot be explained by any structural or biochemical abnormalities. Functional dyspepsia (FD) represents one of the important GI disorders in Western countries because of its remarkably high prevalence in general population and its impact on quality of life. Due to its dependence on both subjective determinants and diverse country-specific circumstances, the definition and management strategies of FD are still variably stated.Clinical trials with several drug classes (e.g., proton pump inhibitors, H2-blockers, prokinetic drugs) have been performed frequently without validated diseasespecific test instruments for the outcome measurements.Therefore, the interpretation of such trials remains difficult and controversial with respect to comparability and evaluation of drug efficacy, and definite conclusions can be drawn neither for diagnostic management nor for efficacious drug therapy so far. In view of these unsolved problems, guidelines both on the clinical management of FD and on the performance of clinical trials are needed. In recent years, increasing research work has been done in this area. Clinical trials conducted in adequately diagnosed patients that provided validated outcome measurements may result in better insights leading to more effective treatment strategies.Encouraging perspectives have been recently performed by methodologically well-designed treatment studies with herbal drug preparations. Herbal drugs, given their proven efficacy in clinical trials, offer a safe therapeutic alternative in the treatment of FD which is often favored by both patients and physicians. A fixed combination of peppermint oil and caraway oil in patients suffering from FD could be proven effective by well-designed clinical trials.

  3. Validation of phone interview for follow-up in clinical trials on dyspepsia: evaluation of the Glasgow Dyspepsia Severity Score and a Likert-scale symptoms test.

    Science.gov (United States)

    Calvet, X; Bustamante, E; Montserrat, A; Roqué, M; Campo, R; Gené, E; Brullet, E

    2000-08-01

    To validate two widely used dyspepsia scores performed by phone interview. Spanish translations of the Glasgow Dyspepsia Severity Score and a Likert-scale symptomatic test were evaluated. Responsiveness to the treatment, validity of the tests, and reproducibility of tests performed by phone interview were assessed. Gastroenterology and endoscopy unit of a county hospital. Group I consisted of 16 ulcer patients undergoing Helicobacter pylori eradication; Group II consisted of 29 healthy volunteers; and Group III consisted of 95 patients undergoing upper endoscopy. Glasgow Severity Dyspepsia Score and Likert test. Both tests showed adequate improvement (responsiveness) after H. pylori eradication. With regard to validity, the Glasgow and Likert test were significantly higher in 95 patients undergoing endoscopy than in 29 healthy controls. Analysis of reproducibility showed that intraobserver variation was low on both the Glasgow and Likert scores. No differences were found between consecutive tests regardless of whether both were performed by phone (24 patients) or one by phone and the other by clinical interview (40 patients). Interobserver variation analysis showed that the Glasgow test remained highly reproducible even when performed by different observers using different methods (clinical interview 8.83, phone 8.44, P = 0.12). By contrast, Likert-scale tests showed significant differences between observers for all symptoms except abdominal pain. (1) The Glasgow score is highly reproducible even when performed by different observers and using different methods. (2) By contrast, Likert tests show greater variability. To be reproducible in different conditions, they need to be performed by the same observer.

  4. Randomized controlled trial of modified Banxia Houpo decoction in treating functional dyspepsia patients with psychological factors

    Institute of Scientific and Technical Information of China (English)

    肖琳

    2013-01-01

    Objective To observe the therapeutic effect of Modified Banxia Houpo Decoction(MBHD)in treating patients with functional dyspepsia(FD)accompanied with psychological factors,and to compare it with Domperidone,Neurostan,and Domperidone+Neurostan.Methods Recruited were 89 FD patients

  5. Test-and-Treat Strategies for Helicobacter pylori in Uninvestigated Dyspepsia: A Canadian Economic Anaylsis

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    John K Marshall

    2000-01-01

    Full Text Available BACKGROUND: Recognition of the pivotal role of Helicobacter pylori in the pathogenesis of peptic ulcer disease has revolutionized primary care approaches to dyspepsia. Decision analysis was used to compare the cost effectiveness of empirical ranitidine with a test and treat strategy using either H pylori serology or the 13carbon-urea breath test (13C-UBT.

  6. Prevalence of Helicobacter pylori infection among new outpatients with dyspepsia in Kuwait

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    Alateeqi Nabeel

    2010-02-01

    Full Text Available Abstract Background Testing and treatment for Helicobacter pylori has become widely accepted as the approach of choice for patients with chronic dyspepsia but no alarming features. We evaluated H. pylori status among outpatients with uninvestigated dyspepsia in Kuwait. Methods A prospectively collected database for 1035 patients who had undergone 13C-urea breath tests (UBT for various indications was reviewed for the period from October 2007 to July 2009. The status of H. pylori in dyspeptic patients was determined by UBT. Results Among the 362 patients who had undergone UBT for uninvestigated dyspepsia, 49.7% were positive for H. pylori (95% CI = 44%-55% and the percentage increased with age (35.8% at 20-29 years, 95% CI = 25.4% - 47.2%; 59.3% at 30-39 years, 95% CI = 48.5% - 69.5% (P = 0.013. The prevalence of H. pylori was 42.6% among Kuwaitis (95% CI = 35%-50% and 57.6% (95% CI = 49.8%-65% among expatriates (p = 0.004. The prevalence among males was 51.3%, while in females it was 48.6%. Conclusions Almost half of the patients with dyspeptic symptoms in Kuwait were positive for H. pylori, though the prevalence varied with age and was higher among expatriates. The American Gastroenterology Association guidelines recommending testing and treatment for H. pylori for patients with uninvestigated dyspepsia should be endorsed in Kuwait.

  7. Randomized-controlled trial of esomeprazole in functional dyspepsia patients with epigastric pain or burning

    DEFF Research Database (Denmark)

    Talley, N J; Vakil, N; Lauritsen, K;

    2007-01-01

    BACKGROUND: Early identification of true responders to acid suppression in functional dyspepsia patients with symptoms of epigastric pain or burning may enable clinicians to optimally tailor treatment. AIM: To evaluate whether a 1-w acid suppression trial is useful for identifying true responders...

  8. Modified Chaihu Shugan Powder for Functional Dyspepsia: Meta-Analysis for Randomized Controlled Trial

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    Nan Yang

    2013-01-01

    Full Text Available Context. Modified Chaihu Shugan powder (MCSP is a popular traditional Chinese herbal formula for functional dyspepsia, which is revised from Chaihu Shugan San and recorded in a medical classic works of China. However, its role and effect in treating functional dyspepsia have not been well established. Objective. To assess the effect and safety of modified Chaihu Shugan powder for functional dyspepsia. Methods. We searched the published and unpublished studies up to August 2012. Only RCTs of modified Chaihu Shugan powder with or without prokinetic drugs versus prokinetic drugs in the patients diagnosed with functional dyspepsia were included. Results. Twenty-two clinical trials involving 1998 participants were included. There were evidences that modified Chaihu Shugan powder (RR = 1.20, 95%, CI 1.14 to 1.27 and modified Chaihu Shugan powder plus prokinetic drugs (RR = 1.18, 95%, CI 1.11 to 1.25 were significantly better treatment options than prokinetic drugs alone in improving symptoms. No serious adverse events were described in the included trials. Conclusions. This meta-analysis showed that modified Chaihu Shugan powder alone or in combination with prokinetic drugs might be more effective than prokinetic drugs alone. However, with poor methodological quality, all the included trials were at high risk of bias. Further large-scale high-quality trials are required for assessment.

  9. Serologic and Urine Diagnostic Tests to Detect Helicobacter pylori Infection in Functional Dyspepsia Patients

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    Agasjtya Wisjnu Wardhana

    2016-12-01

    Full Text Available Background: Dyspepsia is a collection of symptoms in the forms of discomfort, pain, nausea, vomiting, bloating, and early satiety in the stomach. This condition can be caused by various problems; one of them is Helicobacter pylori infection. Dyspepsia without organic problem is known as functional dyspepsia. H. pylori examination is recommended in functional dyspepsia patients. Method: In this study, we performed a diagnostic test study in dyspepsia patients in Community Health Centre of Koja District, North Jakarta, from February to April 2015. Samples were obtained through consecutive sampling method; 74 patients were included. The data was gathered by distributing questionnaires to patients, performing urea breath test (UBT examination, serologic test, and urine test using rapid urine test (RAPIRUN. Results: Prevalence of H. pylori infection by using UBT examination reached up to 36.5%; meanwhile serologic and RAPIRUN tests showed positive results in 32.4% and 24.3% patients, respectively. Serologic test has sensitivity of 74% (95% CI: 55-87%, specificity 91% (95% CI: 80-97%, positive predictive value (PPV 83% (95% CI: 64-93%, and negative predictive value (NPV 86% (95% CI: 74-93%. Meanwhile, RAPIRUN has sensitivity of 63% (95% CI: 44-78%, specificity 98% (95% CI: 89-100%, PPV 94% (95% CI: 74-99%, and NPV 82% (95% CI: 70-90%. Conclusion: Sensitivity of serologic and RAPIRUN tests are still inadequate to be alternative to UBT examination. However, they have high specificity. Further studies are required with larger sample size and consideration of factors which may influence the results of both tests.

  10. Rome III criteria cannot distinguish patients with chronic gastritis from those functional dyspepsia patients.

    Science.gov (United States)

    Wei, Zhu; Ying, Liu; Wen, Guo; Mengnan, Zhang; Yali, Zhang

    2014-04-01

    Functional dyspepsia is thought to be a diagnosis made after excluding endoscopically detectable lesions by the current Rome III criteria. However, whether these "functional dyspepsia" patients were diagnosed appropriately is still controversial. A total of 223 patients diagnosed with functional dyspepsia by Rome III criteria were enrolled. All patients were submitted to endoscopic examination, rapid urease test, and histologic evaluation. We also appraised the effect of a 7-day treatment based on the Glasgow Dyspepsia Severity Score. Helicobacter pylori infection and neutrophil infiltration were found in 37.7% and 36.3% cases, respectively, and were both more frequent in the subgroup with epigastric pain symptom (EPS) than in the other two subgroups. In addition, neutrophil infiltration was more common and severe in the H. pylori-positive individuals than in the patients without infection (Mann-Whitney U-test = 431.500, p < .001). The treatment was useful in symptom improvement of all three subgroups, and the EPS subgroup had the greatest change of symptom scores before and after treatment as compared with the subgroup with postprandial distress symptom (PDS) and PDS/EPS subgroup (χ(2) = 42.745, p < .001), and the eradication of H. pylori revealed a statistical significant difference in different subgroups (χ(2) = 11.300, p = .001). Our findings showed that many H. pylori-positive subjects diagnosed as "functional dyspepsia" were actually chronic gastritis patients, especially the EPS cases who are more likely to be patients with "active gastritis under microscope," and also benefit most from the treatment of proton-pump inhibitors or eradication of H. pylori. © 2014 John Wiley & Sons Ltd.

  11. The effect of Buspirone on symptoms and quality of life in patients with functional dyspepsia

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    Seyed masood Tabib

    2007-09-01

    Full Text Available Background: Functional dyspepsia (FD is a heterogeneous disorder of yet unknown etiology which causes a significant reduction in the quality of life. In this study, we compared the effect of buspirone as an agonist of serotonin 5HT1A receptor with amitriptyline and placebo on improving the symptoms and quality of life in patients with functional dyspepsia. Methods: This study was a double-blinded, randomized controlled clinical trial. Using a sequential sampling, patients with the diagnostic criteria of Rome 2 and normal gastrointestinal findings were selected. The subjects were randomly divided into three therapeutic groups receiving amitriptyline, buspirone, and placebo. We used Nepean Dyspepsia Inde (NDI to evaluate the quality of life before and after the treatment. Results: The mean age of subjects was 35.38±12.94 years. Symptom and quality of life scores of the three groups were equal at the beginning but at the end of treatment, these scores were different. Buspirone was more effective than both amitriptyline and placebo in reducing the symptom of early satiety. Buspirone showed a better improvement in quality of life compared to placebo. Both Buspirone and amitriptyline were more effective than placebo in decreasing the symptom of epigastric pain. Conclusion: Our study confirmed the positive effect of buspirone on the quality of life and symptoms (like early satiety and abdominal pain in patients with functional dyspepsia. Since the mechanism of action of buspirone and also the pathophysiology of functional dyspepsia are still unknown, further studies are necessary to clarify every aspect of the disease and therapeutic effects of various treatments on it.

  12. Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia: A prospective study

    Institute of Scientific and Technical Information of China (English)

    Barbara Grazioli; Francesco Luzza; Giovanni Matera; Costanza Laratta; Giuseppina Schipani; Giovanni Guarnieri; Ester Spiniello; Maria Imeneo; Andrea Amorosi; Alfredo Focà

    2006-01-01

    AIM: To evaluate the prevalence of Giardia lamblia (G.lamblia) infection in patients with irritable bowel syndrome (IBS) and dyspepsia and to establish which is the most accurate test to diagnose the infection in this setting.METHODS: One hundred and thirty-seven patients who consecutively attended the Outpatient Gastroenterology Clinic for the first time between January 2002 and December 2003 due to symptoms of IBS and/or dyspepsia were recruited. All patients underwent clinical evaluation,first-step haematology and chemistry tests, serologic assays for celiac disease, lactose-H2 breath test, abdominal ultrasonography, and esophagogastroduodenoscopy.Helicobacter pylori status was evaluated. In patients with symptoms of IBS older than 45 years, colonoscopy was also performed. In all patients, duodenal biopsies and stool samples were examined for trophozoites and cysts of G.lamblia by several methods.RESULTS: G. lamblia was identified in 9 patients. The following diagnoses were also made: IBS (100/137, 73%), functional dyspepsia (62/137, 45%), organic dyspepsia (33/137, 24%), and lactose intolerance (75/137, 55%). A significant association was found between giardiasis and Hpylori infection (x2=6.632,OR= 12.4, CI= 1.5-68.1). There were no symptoms that reliably allowed the recognition of giardiasis.Direct search of the parasite in duodenal biopsy and stool sample examinations gave concordant results in all cases while histological examination of duodenal biopsies displayed a low sensitivity (e.g., 22.2%).CONCLUSION: In this consecutive series, diagnosis of G. lamblia infection accounted for 6.5% of patients with IBS and dyspepsia. Duodenal biopsies for diagnosis of giardiasis may be unnecessary if stool sample examination is performed.

  13. Evidence-Based Recommendations for Short- and Long-Term Management of Uninvestigated Dyspepsia in Primary Care: An Update of the Canadian Dyspepsia Working Group (CanDys) Clinical Management Tool

    OpenAIRE

    van Zanten, Sander JO Veldhuyzen; Bradette, Marc; Chiba, Naoki; Armstrong, David; Barkun, Alan; Flook, Nigel; Thomson, Alan; Bursey, Ford

    2005-01-01

    The present paper is an update to and extension of the previous systematic review on the primary care management of patients with uninvestigated dyspepsia (UD). The original publication of the clinical management tool focused on the initial four- to eight-week assessment of UD. This update is based on new data from systematic reviews and clinical trials relevant to UD. There is now direct clinical evidence supporting a test-and-treat approach in patients with nondominant heartburn dyspepsia s...

  14. Evidence-Based Recommendations for Short- and Long-Term Management of Uninvestigated Dyspepsia in Primary Care: An Update of the Canadian Dyspepsia Working Group (CanDys Clinical Management Tool

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    Sander JO Veldhuyzen van Zanten

    2005-01-01

    Full Text Available The present paper is an update to and extension of the previous systematic review on the primary care management of patients with uninvestigated dyspepsia (UD. The original publication of the clinical management tool focused on the initial four- to eight-week assessment of UD. This update is based on new data from systematic reviews and clinical trials relevant to UD. There is now direct clinical evidence supporting a test-and-treat approach in patients with nondominant heartburn dyspepsia symptoms, and head-to-head comparisons show that use of a proton pump inhibitor is superior to the use of H2-receptor antagonists (H2RAs in the initial treatment of Helicobacter pylori-negative dyspepsia patients. Cisapride is no longer available as a treatment option and evidence for other prokinetic agents is lacking. In patients with long-standing heartburn-dominant (ie, gastroesophageal reflux disease and nonheartburn-dominant dyspepsia, a once-in-a-lifetime endoscopy is recommended. Endoscopy should also be considered in patients with new-onset dyspepsia that develops after the age of 50 years. Conventional nonsteroidal anti-inflammatory drugs, acetylsalicylic acid and cyclooxygenase-2-selective inhibitors can all cause dyspepsia. If their use cannot be discontinued, cotherapy with either a proton pump inhibitor, misoprostol or high-dose H2RAs is recommended, although the evidence is based on ulcer data and not dyspepsia data. In patients with nonheartburn-dominant dyspepsia, noninvasive testing for H pylori should be performed and treatment given if positive. When starting nonsteroidal anti-inflammatory drugs for a prolonged course, testing and treatment with H2RAs are advised if patients have a history of previous ulcers or ulcer bleeding.

  15. CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THE CHRONIC GASTRITIS WITH FUNCTIONAL DYSPEPSIA IN THE REPUBLIC OF SAKHA (YAKUTIA).

    Science.gov (United States)

    Avvakumova, N V; Chibyeva, L G; Vasiliev, N N

    2015-01-01

    Chronic gastritis with syndrome, functional dyspepsia (SFD) is one of the most pressing problems in medicine. Certain scientific and practical interest is the elucidation of the frequency and clinical manifestations of functional dyspepsia in patients hospitalized in the gastroenterology department YAGKB and frequency combinations of chronic gastritis (including H. pylori) with functional dyspepsia. The aim of the study was to investigate the clinical and morphological features of the chronic gastritis with syndrome pattern of functional dyspepsia in native-born and people of the Republic of Sakha (Yakutia), and to assess the effectiveness of treatment, depending on the gastric acid and H. pylori. This study examined 105 patients with functional dyspepsia, including 41 patients with epigastric pain syndrome and 64 patients with postprandial distress syndrome. Considered groups of patients were homogeneous for age, gender, by ethnicity. Of the 105 patients included in the study, I group were 57 indigenous people (80% of them--Yakutia), 11 group--48 people visiting (Caucasians). Clinical presentation and course of chronic gastritis with functional dyspepsia in the Republic of Sakha (Yakutia) have a number of distinctive features: epigastric pain syndrome occurs in 26.8% of patients and 73.2% of the indigenous population of the visitor, the intensity of pain in the root is much lower than that of visitors--12 and 85% respectively. Postprandial distress syndrome was diagnosed in 71.9% of patients and 28.1% of the indigenous newcomers. At endoscopy in all patients with functional dyspepsia diagnosed chronic gastritis. The native inhabitants of the most common mixed gastritis (54.5%), the newcomers--superficial gastritis (66.7%). The found features of a current of functional dyspepsia can be further the basis for the individualized and differentiated approaches to treatment of this disease.

  16. ENDOSCOPIC AND HISTOPATHOLOGIC CHANGES IN CHILDREN WITH CHRONIC DYSPEPSIA IN A RURAL MEDICAL COLLEGE HOSPITAL IN MELMARUVATHUR- TAMILNADU

    OpenAIRE

    Padma K; Sumathi S.; Dinakaran Nagendram; Kannan C

    2016-01-01

    INTRODUCTION Chronic pain abdomen and dyspepsia is the most common presenting symptoms in the Paediatric Outpatient Department (OPD) after respiratory illnesses. It is increasing alarmingly both in the paediatric and adult population. We, therefore carried out a cross-sectional study among children with chronic dyspepsia aged between 5 to 15 years attending Paediatric OPD in a rural medical college hospital, Melmaruvathur, Tamilnadu, South India. OBJECTIVE To evaluate the ga...

  17. The EQ-5D (Euroqol is a valid generic instrument for measuring quality of life in patients with dyspepsia

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    Goh Khean-Lee

    2009-03-01

    Full Text Available Abstract Background There is little information of the validity of generic instruments in measuring health-related quality of life (HRQOL in patients with dyspepsia. We aimed to assess the reliability and validity of the EQ-5D, a brief and simple instrument, in measuring HRQOL in adult patients with dyspepsia. Methods Consecutive adults with dyspepsia attending the Gastroenterology clinic in a tertiary referral center were interviewed with the EQ-5D (both English and Malay versions, the short-form Nepean Dyspepsia Index (SF-NDI, the SF-36 and Leeds Dyspepsia Questionnaire (LDQ. Known-groups and convergent construct validity were investigated by testing hypotheses at attribute and overall levels. A repeat telephone interview was conducted 2 weeks later to assess test-retest reliability. Results A total of 113 patients (mean (SD age: 53.7 (14 years; 49.5% male; 24.8% Malays, 37.2% Chinese; 70.8% functional dyspepsia were recruited. Response rate was 100% with nil missing data. Known-groups validation revealed 20/26 hypotheses fulfillment. Patients with more severe dyspepsia reported more problems with their usual activity (p = 0.07 and pain (p = 0.06 and demonstrated lower median VAS scores (60 vs 70, p = 0.002 and EQ-5D utility scores (0.72 vs 0.78, p = 0.002. Those reporting problems in various EQ-5D dimensions had significantly lower scores in relevant SF-36 and SF-NDI dimensions. The overall EQ-5D utility score also demonstrated good correlation with the SF-36 summary physical and mental scores and the SF-NDI total score. Intraclass correlation coefficient for test-retest reliability was 0.66 (95% CI = 0.55 – 0.76. Conclusion The EQ-5D is an acceptable, valid and reliable generic instrument for measuring HRQOL in adult patients with dyspepsia.

  18.   A Cost-Effectiveness Analysis of Two Management Strategies for Dyspepsia

    DEFF Research Database (Denmark)

    Kjeldsen, Hans Chr; Bech, Mickael; Christensen, Bo

    2007-01-01

    Objectives: To compare the cost-effectiveness of endoscopy and empirical proton pump inhibition (PPI) therapy for management of dyspepsia in primary care. Methods: A randomized controlled trial (RCT) including prospective collection of economic resource data was conducted in general practice from...... June 2000 to August 2002, Aarhus County, Denmark. We randomly assigned 368 dyspeptic patients from 32 general practices to treatment with omeprazol 40 mg for two weeks (n: 184) or endoscopy (n: 184). The study adopted a societal perspective, and the year of costing was 2006. Outcome measures: days free...... of dyspeptic symptoms and proportion of patients with dyspepsia after one year based on patients' and general practitioners' (GPs') assessment. Costs were estimated from patient and GP questionnaires and from medical records. Results: The incremental cost-effectiveness (CE) ratio for one day free of dyspeptic...

  19. Functional dyspepsia and irritable bowel syndrome, are they different entities and does it matter?

    Institute of Scientific and Technical Information of China (English)

    Kok-Ann Gwee; Andrew Seng Boon Chua

    2006-01-01

    A high prevalence of overlap between functional dyspepsia and irritable bowel syndrome has been consistently and universally reported. Recent studies demonstrating shared common pathophysiological disturbances including delayed gastric emptying and visceral hypersensitivity involving more than one region,suggest that these patients have a generalised rather than regional, disorder of the gut. Furthermore, a study of the natural history of dyspepsia suggests that with time, a substantial proportion will evolve into IBS. The recognition of IBS in dyspeptic patients has potentially profound therapeutic importance. It could help to reduce the risk of unnecessary cholecystectomy in IBS patients.The ability to appreciate the extent of involvement could allow us to address the disturbances more comprehensively, and thereby achieve greater patient satisfaction with their treatment.

  20. Prevalence of Helicobacter pylori infection in maintenance hemodialysis patients with non-ulcer dyspepsia

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    Asl Mohammad Kazem

    2009-01-01

    Full Text Available The purpose of this prospective study is to determine the prevalence of Helico-bacter pylori (H. pylori infection among stable chronic hemodialysis (HD patients having non ulcer dyspepsia. The study was carried out on 80 patients consisting of 40 patients with dyspepsia and 40 consecutive control subjects without renal disease and dyspepsic symptoms. Mean age of patients were 56 ± 14 and 47 ± 15 respectively. This study showed no significant difference of H. pylori infection between the two groups. Tissue examination of gastric antrum showed higher localization of H. pylori in HD patients in contrast to controls. This finding has not been reported before and needs further confirmation and evaluation for its significance.

  1. QUALITY OF LIFE AND ASSOCIATED PSYCHOLOGICAL FACTORS IN PATIENTS WITH FUNCTIONAL DYSPEPSIA

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    ERIKA CANO

    2006-10-01

    Full Text Available The aim of this work was to investigate relationships between life quality, ways of coping, personality and socialsupport in a sample of 60 participants (43 women and 17 men with a diagnosis of non-ulcer dyspepsia, ranging in agefrom 18 to 60 years. We used self-report questionnaires of life quality (Dyspepsia Related Health Scale, QOLPE-I; Ruiz etal., 2000, ways of coping (Cuestionario de Afrontamiento del Estrés, CAE; Sandin & Chorot, 2003, personality (EysenckPersonality Questionnaire Revised-Abbreviated, EPQR-A; Sandin et al., 2002, and social support (cuestionario de ApoyoSocial, [AS]; Matud, 1998. Significant differences were found on ways of coping related to problem solving, positivereappraisal and evitation.

  2. Evaluation of small intestine bacterial overgrowth in patients with functional dyspepsia through H2 breath test

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    Michelle Bafutto Gomes Costa

    2012-12-01

    Full Text Available CONTEXT: Functional dyspepsia is a condition in which symptoms are not related to organic underlying disease; its pathogenesis is not well known. The small intestinal bacterial overgrowth (SIBO is characterized by the increase in the number and/or type of colonic bacteria in the upper gastrointestinal tract. The hypothesis of SIBO being associated to functional dyspepsia must be considered, since the impaired motility of the gastrointestinal tract is one of the main etiologic factors involved on both pathologies. OBJECTIVE: To determine if there is SIBO in patients with functional dyspepsia. METHODS: Case-control study, evaluating 34 patients: 23 functional dyspeptic and 11 non-dyspeptic (control group. Questionnaire applied based on Rome III criteria. The patients underwent H2-lactulose breath test, considered positive when: H2 peak exceeding 20 ppm, in relation to fasting, or two peaks exceeding 10 ppm sustained until 60 minutes. RESULTS: Of the 23 dyspeptic patients, 13 (56.5% obtained positive results for SIBO trough the H2-lactulose breath test. On control group, SIBO was not observed. The association between the dyspeptic group and the control group regarding SIBO was statistically significant, with P = 0.0052. In the group of dyspeptic patients, 12 (52.2% were using proton pump inhibitor; of these 9 (75% were positive for SIBO. In the control group, none of the 11 patients used proton pump inhibitors and SIBO was not observed. The association of the dyspeptic group using proton pump inhibitor that were positive for SIBO and the control group was statistically significant, with P = 0.0011. CONCLUSION: It was found that, patients with functional dyspepsia presented SIBO, when they underwent to H2-lactulose breath test, compared to the non-dyspeptic. In addition, it was observed a higher prevalence of SIBO in dyspeptic patients that were using proton pump inhibitors, compared to control group.

  3. Effect of domperidone therapy on nocturnal dyspeptic symptoms of functional dyspepsia patients

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate the incidence of nocturnal dyspeptic symptoms in patients with functional dyspepsia(FD) and whether prokinetic drugs can alleviate them. METHODS:Eighty-five consecutive Chinese patients with FD were included in this study.One week after single-blinded placebo run-in treatment,baseline nocturnal intragastric pH,bile reflux and nocturnal dyspeptic symptoms of eligible patients,including epigastric pain or discomfort,abdominal distention and belching, were investigated with questionnaires.Pa...

  4. The Value of Alarm Features in Identifying Organic Causes of Dyspepsia

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    Lone Galmstrup Madsen

    2000-01-01

    Full Text Available The unaided clinical diagnosis of dyspepsia is of limited value in separating functional dyspepsia from clinically relevant organic causes of dyspepsia (gastric and esophageal malignancies, peptic ulcer disease and complicated esophagitis. The identification of one or more alarm features, such as weight loss, dysphagia, signs of gastrointestinal bleeding, an abdominal mass or age over 45 years may help identify patients with a higher risk of organic disease. This review summarizes the frequency of alarm symptoms in dyspeptic patients in different settings (such as the community, primary care and specialist clinics. The prevalence of alarm features in patients diagnosed with upper gastrointestinal malignancy or peptic ulcer disease is described. The probability of diagnosing clinically relevant upper gastrointestinal disease in patients presenting with alarm features and other risk factors is discussed. Alarm features such as age, significant weight loss, use of nonsteroidal anti-inflammatory drugs, signs of bleeding and dysphagia may help stratify dyspeptic patients and help optimize the use of endoscopy resources.

  5. The effects of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia

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    Aktas, A. [Baskent Univ., Ankara (Turkey); Caner, B.; Ozturk, F.; Bayhan, H.; Narin, Y.; Mentes, T.

    1999-08-01

    The study was designed to investigate the effect of trimebutine maleate, a drug used in both hyperkinetic and hypokinetic motility disorders, on gastric emptying in patients with non-ulcer dyspepsia having prolonged gastric emptying rates and to compare the parameters used for the determination of the lag period observed during the emptying of solid foods from the stomach. Gastric emptying was measured by the radionuclide technique. Twenty normal volunteers and 43 patients with non-ulcer dyspepsia participated in the study. Radionuclide imaging was performed by using a solid meal labeled with {sup 99m}Tc-tin colloid. Of the patients with non-ulcer dyspepsia, 20 had prolonged gastric emptying. They were given three weeks of oral treatment with trimebutine maleate and had their radionuclide gastric emptying study repeated. Treatment with trimebutine maleate resulted in reduction in duration of the lag period and less retention of food at 100 minutes (p<0.0005). After treatment with trimebutine maleate, no significant difference has been observed in the mean symptom score of patients with prolonged gastric emptying. Among the parameters used for the determination of the lag period, lag period determined by a mathematical equation (TLAG) has been found to be longer than the lag period determined by visual inspection of the images (VLAG) and there was correlation between the two parameters when the lag time was short. (author)

  6. Non-ulcer dyspepsia associated with NSAID intake: possibility of antacid drugs application

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    A. E. Karateev

    2003-01-01

    Full Text Available Objective. To investigate the comparative efficacy of Magalphil 800 in NSAID-associated dyspepsia. Patients and methods. 30 pts with rheumatic diseases (RD receiving NSAIDs and having dyspeptic symptoms were included. Pts were divided into 2 groups: group 1 (n=20, 2 males, 18 females, mean age 51,7+12,3 yTs, 7 pts had single erosion of stomach, 1 - multiple erosions, 1 - ulcer of stomach; group 2 (n=10, 1 male. 9 females, mean age 46,2±14,6 yrs, 2 pts had single erosion of stomach. Concomitant therapies (corticosteroids, cytotoxics were approximately the same in both groups. Pts in Group 1 received one tablet of Magalphil 800 four times a day; pts in Group 2 were treated by ranitidine 150 mg bid. Therapy of RD was not changed during the study. Subjective complains were controlled after 2 weeks. Results. Complains related to dyspepsia disappeared in all pts of Group 1 and in 8 pts of Group 2 after 5,2±2,4 and 7,3±3,8 days of treatment respectively (p>0,05. Healing of ulcer in 1 and healing of erosions in 5 pnts was observed in Group 1. Conclusions. Magalphil 800 is effective in NSAID-associated dyspepsia and can be used for treatment of NSAID-induced gastropathy.

  7. Effect of ginger on gastric motility and symptoms of functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Ming-Luen Hu; Christophan K Rayner; Keng-Liang Wu; Seng-Kee Chuah; Wei-Chen Tai; Yeh-Pin Chou; Yi-Chun Chiu; King-Wah Chiu; Tsung-Hui Hu

    2011-01-01

    AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner.After an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g)or placebo,followed after 1 h by 500 mL low-nutrient soup.Antral area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral area.Gastrointestinal sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the study.RESULTS:Gastric emptying was more rapid after ginger than placebo [median(range)half-emptying time 12.3(8.5-17.0)min after ginger,16.1(8.3-22.6)min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ghrelin.CONCLUSION:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides.

  8. The Rome III criteria for the diagnosis of functional dyspepsia in secondary care are not superior to previous definitions.

    Science.gov (United States)

    Ford, Alexander C; Bercik, Premysl; Morgan, David G; Bolino, Carolina; Pintos-Sanchez, Maria Ines; Moayyedi, Paul

    2014-04-01

    Although the Rome III criteria for functional dyspepsia were defined 7 years ago, they have yet to be validated in a rigorous study. We addressed this issue in a secondary-care population. We analyzed complete symptom, upper gastrointestinal (GI) endoscopy, and histology data from 1452 consecutive adult patients with GI symptoms at 2 hospitals in Hamilton, Ontario, Canada. Assessors were blinded to symptom status. Individuals with normal upper GI endoscopy and histopathology findings from analyses of biopsy specimens were classified as having no organic GI disease. The reference standard used to define the presence of true functional dyspepsia was epigastric pain, early satiety or postprandial fullness, and no organic GI disease. Sensitivity, specificity, and positive and negative likelihood ratios (LRs), with 95% confidence intervals (CIs), were calculated. Of the 1452 patients, 722 (49.7%) met the Rome III criteria for functional dyspepsia. Endoscopy showed organic GI disease in 170 patients (23.5%) who met the Rome III criteria. The Rome III criteria identified patients with functional dyspepsia with 60.7% sensitivity, 68.7% specificity, a positive LR of 1.94 (95% CI, 1.69-2.22), and a negative LR of 0.57 (95% CI, 0.52-0.63). In contrast, the Rome II criteria identified patients with functional dyspepsia with 71.4% sensitivity, 55.6% specificity, a positive LR of 1.61 (95% CI, 1.45-1.78), and a negative LR of 0.51 (95% CI, 0.45-0.58). The area under a receiver operating characteristics curves did not differ significantly for any of the diagnostic criteria for functional dyspepsia. In a validation study of 1452 patients with GI symptoms, the Rome III criteria performed only modestly in identifying those with functional dyspepsia, and were not significantly superior to previous definitions. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

  9. Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia

    Directory of Open Access Journals (Sweden)

    Grobbee Diederick E

    2011-10-01

    Full Text Available Abstract Background The association between anxiety and depression related traits and dyspepsia may reflect a common genetic predisposition. Furthermore, genetic factors may contribute to the risk of having increased visceral sensitivity, which has been implicated in dyspeptic symptom generation. Serotonin (5-HT modulates visceral sensitivity by its action on 5-HT3 receptors. Interestingly, a functional polymorphism in HTR3A, encoding the 5-HT3 receptor A subunit, has been reported to be associated with depression and anxiety related traits. A functional polymorphism in the serotonin transporter (5-HTT, which terminates serotonergic signalling, was also found associated with these psychiatric comorbidities and increased visceral sensitivity in irritable bowel syndrome, which coexistence is associated with higher dyspeptic symptom severity. We investigated the association between these functional polymorphisms and dyspeptic symptom severity. Methods Data from 592 unrelated, Caucasian, primary care patients with dyspepsia participating in a randomised clinical trial comparing step-up and step-down antacid drug treatment (The DIAMOND trial were analysed. Patients were genotyped for HTR3A c.-42C > T SNP and the 44 bp insertion/deletion polymorphism in the 5-HTT promoter (5-HTTLPR. Intensity of 8 dyspeptic symptoms at baseline was assessed using a validated questionnaire (0 = none; 6 = very severe. Sum score ≥20 was defined severe dyspepsia. Results HTR3A c.-42T allele carriers were more prevalent in patients with severe dyspepsia (OR 1.50, 95% CI 1.06-2.20. This association appeared to be stronger in females (OR 2.05, 95% CI 1.25-3.39 and patients homozygous for the long (L variant of the 5-HTTLPR genotype (OR 2.00, 95% CI 1.01-3.94. Females with 5-HTTLPR LL genotype showed the strongest association (OR = 3.50, 95% CI = 1.37-8.90. Conclusions The HTR3A c.-42T allele is associated with severe dyspeptic symptoms. The stronger association among

  10. Effect of antidepressant treatment on water load test and cortisol changes in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: It has been demonstrated that patients with functional dyspepsia have experiences social life stress events, and accompanied by psychological disorders, mainly manifested as depression and anxiety.Mental factors can lead to excessive gastrointestinal consensual reaction, and result in different brain-gut axis disturbance, and then cause the gastrointestinal sensorimotor abnormality and endocrine changes.OBJECTIVE: To observe the effect of antidepressant treatment on the changes of water load and serum cortisol in patients with functional dyspepsia, and analyze the therapeutic mechanism.DESIGN: A comparative observation.SETTING: The First Affiliated Hospital o Zhengzhou University.PARTICIPANTS: Forty-five patients with functional dyspepsia accompanied by depression were selected from the Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University from July 2004 to July 2006, and they were 25 - 65 years of age, and their disease courses ranged 1 - 10 years. They were all accorded with the diagnostic standards for Rome Ⅱ functional dyspepsia functional dyspepsia. As the patients' will, they were divided into treatment group (n =30, 12 males and 18 females) and control group (n =15, 6 males and 9 females), and there were no significant differences in the data between the two groups (P > 0.05). The programs were discussed and agreed by the committee of medical ethics of the First Affiliated Hospital of Zhengzhou University. Informed contents were obtained from all the patients.METHODS: In the treatment group, the patients were treated with venlafaxine sustained release capsule (75 mg per day), and those with sleep disorder were added by benzodiazepines (alprazolam). In the control group, the patients were given routine treatments of antacid, prokinetics, etc. Before and after 8-week treatment, the following examinations were performed: ① The gastrointestinal symptoms were assessed according to the symptoms; ② The severity of

  11. Functional dyspepsia in adolescents: particulars of its etiology, premorbid background, and a comprehensive treatment approach

    Directory of Open Access Journals (Sweden)

    D. V. Pechkurov

    2017-01-01

    Full Text Available The adolescence is characterized by high rates of gastroenterological morbidity due to physiological characteristics of the body and social and psychological status of the teenager. Dyspepsia takes the leading position in the structure of functional pathology. Studies have shown the role of family, unhealthy habits and addictions in the development of this disorder. One should also bear in mind that the adolescence is characterized by an increase in organic pathology. There is a  close association of the functional dyspepsia and the premorbid background, such as autonomous dysfunction and vertebral abnormalities. The use of cholinolytics, prokinetics, opioid receptor antagonists, antacids and anti-secretory agents seems rational for treatment of dyspepsia. If the above mentioned groups of agents lack efficacy, the second line therapy is proposed, which includes tricyclic antidepressants.

  12. The G-Protein β3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia

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    Hori Kazutoshi

    2010-01-01

    Full Text Available Abstract Background Although familial clustering of functional dyspepsia (FD has been reported, the role of genetics in the susceptibility to FD is still not well understood. Several reports indicate an association between FD and G-protein β3 (GNB3 subunit gene polymorphism (C825T; however, these studies had small sample sizes and the findings are inconclusive. In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up. Methods Subjects with significant upper gastrointestinal findings were excluded. Subjects with dyspeptic symptoms were divided into either a postprandial distress syndrome (PDS group or an epigastric pain syndrome (EPS group according to the Rome III criteria. The presence of the GNB3 C825T polymorphism was then evaluated and logistic regression analysis was used to test all variables. Results The GNB3 genotype distribution in subjects without dyspepsia was 191 CC (25.1%, 368 TC (48.4%, and 202 TT (26.5% and 17 CC (25.0%, 29 TC (42.6%, and 22 TT (32.4% in subjects with dyspepsia. No significant correlation was found between the GNB3 825TT genotype and dyspepsia. However, the TT genotype was significantly associated with subjects with EPS-like symptoms (odds ratio (OR = 2.00, 95% confidence interval (CI; 1.07-3.76 compared to the CT/CC genotype adjusted for gender and age. No significant correlation was found between GNB3 polymorphism and PDS-like symptoms (OR = 0.68, 95% CI; 0.31-1.51. With the exclusion of subjects with both EPS- and PDS-like symptoms, only the TT genotype was significantly associated with EPS-like symptoms (OR = 2.73, 95% CI; 1.23-5.91. Conclusion The homozygous GNB3 825T allele influences the susceptibility to EPS-like dyspepsia.

  13. Acupuncture as a treatment for functional dyspepsia: design and methods of a randomized controlled trial

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    Yan Jie

    2009-08-01

    Full Text Available Abstract Background Acupuncture is widely used in China to treat functional dyspepsia (FD. However, its effectiveness in the treatment of FD, and whether FD-specific acupoints exist, are controversial. So this study aims to determine if acupuncture is an effective treatment for FD and if acupoint specificity exists according to traditional acupuncture meridians and acupoint theories. Design This multicenter randomized controlled trial will include four acupoint treatment groups, one non-acupoint control group and one drug (positive control group. The four acupoint treatment groups will focus on: (1 specific acupoints of the stomach meridian; (2 non-specific acupoints of the stomach meridian; (3 specific acupoints of alarm and transport points; and (4 acupoints of the gallbladder meridian. These four groups of acupoints are thought to differ in terms of clinical efficacy, according to traditional acupuncture meridians and acupoint theories. A total of 120 FD patients will be included in each group. Each patient will receive 20 sessions of acupuncture treatment over 4 weeks. The trial will be conducted in eight hospitals located in three centers of China. The primary outcomes in this trial will include differences in Nepean Dyspepsia Index scores and differences in the Symptom Index of Dyspepsia before randomization, 2 weeks and 4 weeks after randomization, and 1 month and 3 months after completing treatment. Discussion The important features of this trial include the randomization procedures (controlled by a central randomization system, a standardized protocol of acupuncture manipulation, and the fact that this is the first multicenter randomized trial of FD and acupuncture to be performed in China. The results of this trial will determine whether acupuncture is an effective treatment for FD and whether using different acupoints or different meridians leads to differences in clinical efficacy. Trial registration number Clinical Trials

  14. Symptoms of depression and quality of life in functional dyspepsia patients

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    Muhammad Eko Cahyanto Neneng Ratnasari Agus Siswanto

    2014-08-01

    Full Text Available Dyspepsia is a common disorder characterized by heartburn, nausea, vomiting, bloating, feelingof fullness or early satiety, and belching. Functional dyspepsia (FD or non-ulcer dyspepsia is asyndrome without any physical or endoscopic abnormalities underlying these symptoms. Theimpacts of FD on psychological disturbances and quality of life in patients have been postulated.However, it has not much been a concern. This study was conducted to evaluate the relationshipbetween symptoms of depression and quality of life in patients with FD. This was an observationalstudy with cross-sectional design involving 30 patients. The symptoms of depression weremeasured by beck depression inventory (BDI and the quality of life of patients were measuredby SF-36. The results showed that FD were more suffered consecutively by female patients(66.7%, age over 45 years (53.4%, housewives (56.6%, educated graduates (56.6% andmarried (90.0%. Moreover, patients who experienced symptoms of clinical depression withlow, moderate and severe levels were 16.3%, 33.3% dan 10.0%, respectively. A significantcorrelation between depressive symptoms and the overall of patients quality of life was observed(r = 0.481; p<0.05. Furthermore analysis showed that among eight domains of health in SF-36analyzed, a negative significant correlation was observed between the depressive symptoms andthe three domains of health i.e. general physical function, limitation of motion caused byphysical problems, and vitality. In conclusion, there is a negative correlation between depressivesymptoms and quality of life in patients with FD.

  15. Upper gastrointestinal endoscopy for dyspepsia: Εxploratory study of factors influencing patient compliance in Greece

    Directory of Open Access Journals (Sweden)

    Kouroumalis Elias

    2011-02-01

    Full Text Available Abstract Background Upper gastrointestinal endoscopy is the most preferable diagnostic examination for patients over fifty when upper gastrointestinal symptoms appear. However, limited knowledge exists in concerns to the compliance of primary care patients' to the doctors' recommendations for endoscopy. Methods Patients who visited primary care practices in Greece and experienced upper gastrointestinal symptoms within a 10 days screening study, were referred for an upper endoscopy exam. The patients which refused to complete the endoscopy exam, were interviewed by the use of an open- ended translated and validated questionnaire, the Identification of Dyspepsia in General Population (IDGP questionnaire. A qualitative thematic analysis grounded on the theory of planned behavior was performed to reveal the reasons for patients' refusal, while socio-demographic predictors were also assessed. Results Nine hundred and ninety two patients were recorded, 159 of them (16% were found positive for dyspepsia and gastro-esophageal reflux disease according to the IDGP questionnaire. Out of the above, 131 (83.6% patients refused further investigation with endoscopy. Patients who refused upper endoscopy were predominantly female (87.8% (p = 0.036 and over the age of 50. The lack of severe symptoms, fear of pain, concerns of sedation, comorbidity and competing life demands were reported by patients as barriers to performing an endoscopic investigation. Conclusions Patients with dyspepsia in rural Greece tend to avoid upper gastrointestinal endoscopy, with two major axons considered to be the causes of patients' refusal: their beliefs towards endoscopy and their personal capability to cope with it. Future research examining reasons of low compliance should be carried out in combination with modern behavioral theories so as to investigate into the above.

  16. From ischochymia to gastroparesis: proposed mechanisms and preferred management of dyspepsia over the centuries.

    Science.gov (United States)

    Bielefeldt, Klaus

    2014-06-01

    Dyspeptic symptoms are common with most patients suffering functional disorders that remain a therapeutic challenge for medical practitioners. Within the last three decades, gastric infection, altered motility, and hypersensitivity have gained and lost traction in explaining the development of functional dyspepsia. Considering these shifts, the aim of this review was to analyze changing understanding of and approaches to dyspepsia over a longer time period. Monographs, textbooks, and articles published during the last three centuries show that our understanding of normal gastric function has improved dramatically. With increased insight came new ideas about disease mechanisms, diagnostic options, and treatments. Despite shifts over time, the importance of functional abnormalities was recognized early on and explained in the context of societal influences and stressors, anxieties, and biological influences, thus resembling the contemporary biopsychosocial model of illness. Symptoms were often attributed to changes in secretion, motility, and sensation or perception with technological innovation often influencing proposed mechanisms and treatments. Many of the principles or even agents applied more than a century ago are still part of today's approach. This includes acid suppression, antiemetics, analgesics, and even non-pharmacologic therapies, such as gastric decompression or electrical stimulation of the stomach. This historical information does not only help us understand how we arrived at our current state of knowledge and standards of care, it also demonstrates that enthusiastic adoption of various competing explanatory models and the resulting treatments often did not survive the test of time. In view of the benign prognosis of dyspepsia, the data may function as a call for caution to avoid the potential harm of overly aggressive approaches or treatments with a high likelihood of adverse effects.

  17. Implementation and evaluation of early gastroscopy for patients with dyspepsia and warning signs in Primary Care.

    Science.gov (United States)

    García-Alonso, Francisco Javier; Hernández Tejero, María; Rubio Benito, Elvira; Valer, Paz; Guerra, Iván; García Ceballos, Victoria Gema; Noguerol, Mar; Llinares, Victoria; Bermejo, Fernando

    2017-05-01

    Dyspepsia is a common disorder in both Primary (PC) and Specialised Care (SC). Gastroscopy is recommended at the start of the study if there are warning signs, although it is not always available in PC. We developed a pilot project establishing an early gastroscopy programme for patients with dyspepsia and warning signs in PC, subsequently extending it to the entire healthcare area. The aim was to evaluate the requirements, impact and opinion of this service at the PC level. Demographic, symptomatic and endoscopic variables on the patients referred to SC from the pilot centre were recorded. A satisfaction survey was conducted among the PC physicians. The one-year pilot study and the first year of implementation of the programme were evaluated. A total of 355 patients were included (median age 56.4 years; IQR 45.5-64.3); 61.2% (56.1-66.3%) were women. The waiting time for examination was 1.5 weeks (IQR 1.5-2.5). Gastroscopy was correctly indicated in 82.7% (78.4-86.3%) of patients. The median number of requests per month was 1.1 per 10,000 adults (range 0.8-1.6). Monthly referrals to SC clinics from the pilot centre fell by 11 subjects (95% CI 5.9-16) with respect to the previous median of 58 (IQR 48-64.5). Almost all those polled (98.4%) considered the programme useful in routine practice. The availability of an early gastroscopy programme in PC for patients with dyspepsia and warning signs reduced the number of referrals to SC. Copyright © 2016 Elsevier España, S.L.U., AEEH y AEG. All rights reserved.

  18. Infantile hypertrophic pyloric stenosis and subsequent ulcer dyspepsia. A follow-up study of medically and surgically treated patients

    DEFF Research Database (Denmark)

    Rasmussen, L; Hansen, L P; Qvist, N

    1988-01-01

    Infantile hypertrophic pyloric stenosis was treated in 324 cases in 1950-1966. At follow-up 19-35 years later, 296 of the patients could be traced, and 284 replied to a questionnaire concerning ulcer dyspepsia. Among the 80 patients who had been medically treated for pyloric stenosis, the prevale......Infantile hypertrophic pyloric stenosis was treated in 324 cases in 1950-1966. At follow-up 19-35 years later, 296 of the patients could be traced, and 284 replied to a questionnaire concerning ulcer dyspepsia. Among the 80 patients who had been medically treated for pyloric stenosis...

  19. Rome III functional dyspepsia subdivision in PDS and EPS: recognizing postprandial symptoms reduces overlap.

    Science.gov (United States)

    Carbone, F; Holvoet, L; Tack, J

    2015-08-01

    The Rome III consensus proposed to subdivide functional dyspepsia (FD) into two groups: meal-related dyspepsia or postprandial distress syndrome (PDS), and meal-unrelated dyspepsia or epigastric pain syndrome (EPS). However, in clinical practice, overlap between both has been reported to be as high as 50%, thereby hampering clinical applicability. Although EPS is referred to as meal-unrelated dyspepsia, relationship of symptoms to meal ingestion in this category is not formally addressed in the Rome III criteria. The aim of our study was to investigate whether taking into account the relationship of epigastric pain and nausea to meal ingestion may help to improve separation between EPS and PDS. Consecutive ambulatory tertiary-care patients with epigastric symptoms filled out Rome III gastro-duodenal questionnaires with supplementary questions. Those fulfilling Rome III FD criteria and a negative endoscopy were identified and subdivided into 'pure' PDS patients (i.e., meeting criteria for PDS without EPS symptoms), 'pure' EPS (i.e., meeting criteria for EPS without PDS symptoms), and overlapping PDS-EPS (i.e., symptoms of both PDS and EPS). Out of 1029 patients coming to endoscopy, 199 patients (73% females, 45.9 ± 1.0 years, BMI: 23.7 ± 0.35) fulfilled Rome III FD diagnostic criteria, and could be subdivided into pure PDS (69% females, 49 ± 2 years, BMI: 24.2 ± 0.61), pure EPS (59% females, 47.4 ± 2 years, BMI: 23.2 ± 0.97) and overlapping PDS-EPS (64% females, age 43 ± 5 years, BMI: 26 ± 0.46). Compared with pure EPS patients, the overlap PDS-EPS patients were characterized by a higher occurrence of postprandial epigastric pain (70% vs 31%, p < 0.0001), while the occurrence of epigastric pain in between meals was borderline (48% vs 38%, p = 0.05). In addition, the overlap PDS-EPS patients reported a higher occurrence of postprandial nausea (23% vs 0%, p < 0.0001), and bloating (79% vs 28%, p = 0.0001). When postprandial epigastric pain and postprandial

  20. Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    John; M; Rosen; Jose; T; Cocjin; Jennifer; V; Schurman; Jennifer; M; Colombo; Craig; A; Friesen

    2014-01-01

    Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets.

  1. Evaluation of thermal water in patients with functional dyspepsia and irritable bowel syndrome accompanying constipation

    Institute of Scientific and Technical Information of China (English)

    Giovanni Gasbarrini; Marcello Candelli; RiccardoGiuseppe Graziosetto; Sergio Coccheri; Ferdinando Di Iorio; Giuseppe Nappi

    2006-01-01

    AIM: To evaluate the efficacy of water supplementation treatment in patients with functional dyspepsia or irritable bowe syndrome (IBS) accompanying predominant constipation.METHODS: A total of 3 872 patients with functional dyspepsia and 3609 patients with irritable bowel syndrome were enrolled in the study by 18 Italina thermal centres.Patients underwent a first cycle of thermal therapy for 21 d. A year later patients were re-evaluated at the same centre and received another cycle of thermal therapy.A questionnare to collect personal data on social and occupational status, family and pathological case history,life style, clinical records, utilisation of welfare and health structure and devices was administered to each patient at basal time and one year after each thermal treatment.Sixty patients with functional dyspepsia and 20 with IBS and 80 healthy controls received an evaluation of gastric output and oro-cecal transit time by breath test analysis.Breath test was performed at basal time and after water supplementaton therapies. Gastrointestinal symptoms were evaluated at the same time points. Breath samples were analyzed with a mass spectometer and a gascromatograph. Results were expressed as T1/2 and T-lag for octanoic acid breath test and as oro-cecal transit time for lactulose breath test.RESULTS: A significant reduction of prevalence of symptoms was observed at the end of the first and second cycles of thermal therapy in dyspeptic and IBS patients.The analysis of variance showed a real and persistant improvement of symptoms in all patients. After water supplementation for 3 wk a reduction of gastric output was observed in 49 (87.5%) of 56 dyspeptic patients.Both T1/2 and T-lag were significantly reduced after the therapy compared to basal values [91± 12 (T1/2) and 53 ± 11 (T-lag), Tables 1 and 2] with results of octanoic acid breath test similar to healthy subjects. After water supplementation for 3 wk oro-cecal transit time was shorter than that at the

  2. Functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort.

    Science.gov (United States)

    Wauters, L; Nightingale, S; Talley, N J; Sulaiman, B; Walker, M M

    2017-05-01

    The pathophysiology of functional dyspepsia (FD) remains unknown. Duodenal eosinophil infiltration has been reported. To assess the association between dyspeptic symptoms and duodenal eosinophilia in children undergoing upper gastrointestinal endoscopy. In this retrospective cohort study, children with normal upper endoscopy and routine histology at a single tertiary paediatric centre between 2010 and 2014 were included. FD was defined as epigastric pain or discomfort >2 months without response to acid suppression. Controls presented with nonerosive reflux disease, dysphagia or rumination syndrome. Intramucosal eosinophil counts were compared between the groups using uni- and multivariate regression analyses. Thirty-six cases and 36 nonmatched controls were identified. Atopic history (39% vs. 25%) and psychological comorbidity (53% vs. 39%; both P = 0.2) were frequent in cases and controls. Self-reported nausea (64% vs. 17%; P 112 eosinophils per mm(2) predictive for FD (OR: 33.6, 95% CI: 7.1-159.0; P eosinophilia was associated with weight loss (OR: 7.1, 95% CI: 1.1-45.5; P = 0.04). Functional dyspepsia in children is strongly associated with duodenal eosinophilia, in the absence of endoscopic or routine histological findings. Frequent atopic and psychological comorbidity illustrate likely multifactorial mechanisms. © 2017 John Wiley & Sons Ltd.

  3. Low Prevalence of Clinically Significant Endoscopic Findings in Outpatients with Dyspepsia

    Science.gov (United States)

    Abdeljawad, Khaled; Wehbeh, Antonios

    2017-01-01

    Background. The value of endoscopy in dyspeptic patients is questionable. Aims. To examine the prevalence of significant endoscopic findings (SEFs) and the utility of alarm features and age in predicting SEFs in outpatients with dyspepsia. Methods. A retrospective analysis of outpatient adults who had endoscopy for dyspepsia. Demographic variables, alarm features, and endoscopic findings were recorded. We defined SEFs as peptic ulcer disease, erosive esophagitis, malignancy, stricture, or findings requiring specific therapy. Results. Of 650 patients included in the analysis, 51% had a normal endoscopy. The most common endoscopic abnormality was nonerosive gastritis (29.7%) followed by nonerosive duodenitis (7.2%) and LA-class A esophagitis (5.4%). Only 10.2% had a SEF. Five patients (0.8%) had malignancy. SEFs were more likely present in patients with alarm features (12.6% versus 5.4%, p = 0.004). Age ≥ 55 and presence of any alarm feature were associated with SEFs (aOR 1.8 and 2.3, resp.). Conclusion. Dyspeptic patients have low prevalence of SEF. The presence of any alarm feature and age ≥ 55 are associated with higher risk of SEF. Endoscopy in young patients with no alarm features has a low yield; these patients can be considered for nonendoscopic approach for diagnosis and management. PMID:28210269

  4. Association of Psychological Characteristics and Functional Dyspepsia Treatment Outcome: A Case-Control Study

    Science.gov (United States)

    Wang, Caihua

    2016-01-01

    This study was to investigate the association of psychological characteristics and functional dyspepsia treatment outcome. 109 patients who met the criteria for FD were enrolled. Eysenck Personality Questionnaire (EPQ), Symptom Checklist 90 (SCL90), and the Pittsburgh Sleep Quality Index (PSQI) were used to measure personality, psychological symptoms, and sleep quality in our patients. Leeds Dyspepsia Questionnaire (LDQ) was used to assess dyspeptic symptoms at baseline and after eight weeks of treatment. The LDQ scores change after therapy, and the degraded rate of LDQ was used to assess the prognosis of patients. Logistic regression model was used to assess the effect of the personality, psychological symptoms, and sleep quality on the prognosis of patients. Our result revealed that poor sleep quality (OR = 7.68, 95% CI 1.83–32.25) and bad marriage status (OR = 1.22, 95% CI 1.10–1.36) had the negative effect on the prognosis of FD, while extroversion in personality traits (OR = 0.86, 95% CI 0.76–0.96) had positive effect on the prognosis of FD. We should pay attention to the sleep quality, the personality, and the marriage status of FD patients; psychological intervention may have benefit in refractory FD. PMID:27547220

  5. Pharmacy students' learning and satisfaction with high-fidelity simulation to teach drug-induced dyspepsia.

    Science.gov (United States)

    Branch, Cleopatra

    2013-03-12

    To assess second-year pharmacy students' acquisition of pharmacotherapy knowledge and clinical competence from participation in a high-fidelity simulation, and to determine the impact on the simulation experience of implementing feedback from previous students. A high-fidelity simulation was used to present a patient case scenario of drug-induced dyspepsia with gastrointestinal bleeding. The simulation was revised based on feedback from a previous class of students to include a smaller group size, provision of session material to students in advance, and an improved learning environment. Student performance on pre- and post-simulation knowledge and clinical competence tests documented significant improvements in students' knowledge of dyspepsia and associated symptoms, with the greatest improvement on questions relating to the hemodynamic effects of gastrointestinal bleeding. Students were more satisfied with the simulation experience compared to students in the earlier study. Participation in a high-fidelity simulation allowed pharmacy students to apply knowledge and skills learned in the classroom. Improved student satisfaction with the simulation suggests that implementing feedback obtained through student course evaluations can be an effective means of improving the curriculum.

  6. THE STUDY OF REACTIVE AND PERSONAL ANXIETY, QUALITY OF LIFE IN PATIENTS WITH DYSPEPSIA IN OUTPATIENT DEPARTMENT

    Directory of Open Access Journals (Sweden)

    E. G. Kunakbaeva

    2016-01-01

    Full Text Available Conducted  a comprehensive  examination  of patients  in the  outpatient department, including laboratory  and instrumental methods,  the  test of Spielberg-Hanina to determine  the level of anxiety, the SF 36 test to determine  the level of quality of life. The survey revealed a decline in the quality of life in patients  with dyspepsia, the indicators of psychological health in organic and functional dyspepsia is lower than in healthy people. The intensity of pain was higher in patients  with epigastric pain syndrome. Lower quality of life were in the group with organic lesions of the upper gastrointestinal tract. The results of the test of Spielberg-Hanin demonstrated high personal anxiety in patients with different types of dyspepsia in comparison with healthy group. The obtained results complement the clinical and pathogenetic information regarding the different kinds of dyspepsia

  7. Is this a reflux patient or is it a patient with functional dyspepsia with additional reflux symptoms?

    DEFF Research Database (Denmark)

    Funch-Jensen, P

    1995-01-01

    of functional dyspepsia is less documented and in most studies the symptomatic pattern could not predict the pharmacologic principle of clinical benefit. This may be because a separation between presence of symptoms and presence of symptoms as a major problem has not been taken into account. Cisapride...

  8. One-year prognosis of primary care dyspepsia : predictive value of symptom pattern, Helicobacter pylori and GP management

    NARCIS (Netherlands)

    Quartero, AO; Numans, ME; Post, MWM; de Melker, RA

    2002-01-01

    Background and aims Dyspepsia is a highly prevalent, heterogeneous condition with a poorly defined clinical course in family practice. We observed its clinical outcome and identified prognostic factors. Patients We studied 583 patients presenting to their general practitioner (GP) with a new episode

  9. [Relationship between the frequency of work-related stress and prevalence of functional dyspepsia in Lima Geriatric Army Hospital].

    Science.gov (United States)

    Valenzuela Narváez, Daniel Raúl; Gayoso Cervantes, Milagros

    2017-01-01

    To determine the relationship between the frequency of work-related stress and prevalence of functional dyspepsia in a sample of 218 military older 50 years in 2010 in Lima Military Hospital Geriatric. Descriptive and explanatory study and for the data collection on stress, were used the Vital Events Scale Holmes-Rahe and clinical records for clinical and upper endoscopy registration that comply the criteria of Rome III for functional dyspepsia. For processing and data analysis the statistical software package SPSS (Statistical Package for Social Sciences) was used. 100% of military showed some level of work stress during the study year; thus, 36.7% had a high level, 31.2% medium or moderate level, and 32.1% had low stress level; these percentages medium and high stress levels accounted for 67.9%. These results establish that job stress is a common discomfort in the study population (tabulated Chi2 = 3.841, chi2 observed = 27,908). Regarding functional dyspepsia prevalence of 37.2%, which indicates that it is a common condition in those military (tabular Z = 1.96, Z c = 9.163) it was determined. There is a significant relationship between the frequency of work-related stress and prevalence of functional dyspepsia in military activity in older than 50 years (tabulated Chi2 = 5.991, chi2 observed = 28,878, contingency coefficient = 0.342).

  10. Prevalência de dispepsia e fatores sociodemográficos Prevalence of dyspepsia and associated sociodemographic factors

    Directory of Open Access Journals (Sweden)

    Sandro Schreiber de Oliveira

    2006-06-01

    Full Text Available OBJETIVO: Medir a prevalência e distribuição de dispepsia e dispepsia freqüente por subtipos na população com 20 anos ou mais segundo características socioeconômicas e demográficas. MÉTODOS: Estudo transversal, de base populacional, com 3.934 indivíduos moradores na cidade de Pelotas (RS, entrevistados em seus domicílios, de outubro de 1999 a janeiro de 2000. Dispepsia foi definida como dor ou desconforto no andar superior do abdome e/ou náuseas no ano anterior à entrevista (conforme critérios Roma I e II. Dispepsia freqüente incluiu o registro de dispepsia mais de seis vezes e/ou náuseas, uma vez por mês ou mais. Esses desfechos foram analisados por idade, sexo, cor da pele, escolaridade, renda e estado civil. Os dados foram analisados por meio do teste qui-quadrado de Pearson de associação para variáveis categóricas e teste de tendência linear, quando aplicável. RESULTADOS: A prevalência de dispepsia foi de 44,4% e de dispepsia freqüente, 27,4%. A prevalência de dispepsia tipo refluxo, úlcera, dismotilidade e não especificada foi, respectivamente, 19,4%, 6,3%, 13,9% e 16,6%; para dispepsia freqüente foram 14,7%, 4,9%, 11,2% e 6,8%, respectivamente. As mulheres apresentaram cerca de 50% mais dispepsia freqüente. Indivíduos mais jovens e de menor renda apresentaram maiores prevalências de dispepsia e dispepsia freqüente. Análise de acordo com critérios de Roma II mostrou prevalências de 15,9% e 7,5% para dispepsia e dispepsia freqüente, respectivamente. CONCLUSÕES: A dispepsia constitui um problema prevalente na população estudada. A maioria dos indivíduos apresentaram mais de um subtipo de dispepsia.OBJECTIVE: To assess prevalence of dyspepsia and distribution of dyspepsia and frequent dyspepsia in subgroups of adults (20 years and older according to their demographic and socioeconomic characteristics. METHODS: A cross-sectional population-based study was carried out comprising 3,934 subjects living in

  11. Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria.

    Science.gov (United States)

    Fang, Yu-Jen; Liou, Jyh-Ming; Chen, Chieh-Chang; Lee, Ji-Yuh; Hsu, Yao-Chun; Chen, Mei-Jyh; Tseng, Ping-Huei; Chen, Chien-Chuan; Chang, Chi-Yang; Yang, Tsung-Hua; Chang, Wen-Hsiung; Wu, Jeng-Yi; Wang, Hsiu-Po; Luo, Jiing-Chyuan; Lin, Jaw-Town; Shun, Chia-Tung; Wu, Ming-Shiang

    2015-10-01

    Whether there is distinct pathogenesis in subgroups of functional dyspepsia (FD), the postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) remains controversial. We aimed to identify the risk factors of FD and its subgroups in the Chinese population. Patients with dyspepsia and healthy subjects who underwent gastric cancer screening were enrolled in this multicentre study from 2010 to 2012. All patients were evaluated by questionnaire, oesophagoduodenoscopy, histological examination and Helicobacter pylori tests. Subgroups of FD were classified according to the Rome III criteria. Psychiatric stress was assessed by the short form Brief Symptom Rating Scale. CagA and VacA genotypes were determined by PCR. Of 2378 patients screened for eligibility, 771 and 491 fulfilled the diagnostic criteria of uninvestigated dyspepsia and FD, respectively. 298 (60.7%) and 353 (71.9%) individuals were diagnosed with EPS and PDS, respectively, whereas 169 (34.4%) had the overlap syndrome. As compared with 1031 healthy controls, PDS and EPS shared some common risk factors, including younger age (OR 0.95; 99.5% CI 0.93 to 0.98), non-steroidal anti-inflammatory drugs (OR 6.60; 99.5% CI 3.13 to 13.90), anxiety (OR 3.41; 99.5% CI 2.01 to 5.77) and concomitant IBS (OR 6.89; 99.5% CI 3.41 to 13.94). By contrast, H. pylori (OR 1.86; 99.5% CI 1.01 to 3.45), unmarried status (OR 4.22; 99.5% CI 2.02 to 8.81), sleep disturbance (OR 2.56; 99.5% CI 1.29 to 5.07) and depression (OR 2.34; 99.5% CI 1.04 to 5.36) were associated with PDS. Moderate to severe antral atrophy and CagA positive strains were also more prevalent in PDS. Different risk factors exist among FD subgroups based on the Rome III criteria, indicating distinct aetiopathogenesis of the subdivisions that may necessitate different therapeutic strategies. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  12. Randomized controlled trial of effectiveness of lafutidine versus pantoprazole in uninvestigated dyspepsia

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    Somnath Maity

    2014-01-01

    Full Text Available Objectives: Lafutidine is a new H 2 -blocker in India claimed to be more potent and effective than existing H 2 -blockers. Proton pump inhibitors (PPIs, by virtue of their mechanism of action, have greater efficacy than H 2 -blockers in gastric acid suppression. However, clinical trials comparing H 2 -blockers directly with PPIs are limited. We carried out a head-to-head comparison of the effectiveness of lafutidine versus the PPI pantoprazole in uninvestigated dyspepsia [CTRI/2013/12/004261]. Materials and Methods: A prospective, open label, randomized, controlled trial was conducted in a tertiary care hospital. Ambulatory adult patients with dyspepsia, not yet subjected to endoscopy, were recruited if they had at least moderately severe symptoms, defined as a score of ≥ 4 on a 7-point Global Overall Symptom (GOS Scale. Those with alarm features or significant comorbidity were excluded. Subjects received either once daily lafutidine 10 mg or pantoprazole 40 mg, orally, for 8 weeks. Reflux, dysmotility and pain scores were assessed by Modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (mFSSGERD, and quality of life (QoL by SF-8 scale. The latter had physical and mental components summarized by physical component summary score (PCS and a mental component summary score (MCS. Results: Of 122 patients enrolled, data of 57 on lafutidine and 60 on pantoprazole were analyzed. At 4 weeks, proportion of subjects responding (GOS score ≤ 2 in the two arms (lafutidine 45.61% vs. pantoprazole 48.33%, P = 0.854 or showing symptom resolution (GOS score ≤ 1 (lafutidine 12.28% vs. pantoprazole 5.00%; P = 0.197 were comparable. Similarly at 8 weeks, both responder (lafutidine 52.63% vs. pantoprazole 56.67%; P = 0.712 and symptom resolution proportions (lafutidine 33.33% vs. pantoprazole 30%; P = 0.843 were comparable. Total score on mFSSGERD scale, as well as all its three component scores, and PCS and MCS scores on QoL SF-8 scale

  13. [Integrative medicine in the management of functional dyspepsia. Role of the herbal preparation STW5].

    Science.gov (United States)

    Sebastián-Domingo, Juan J

    2014-04-01

    Functional dyspepsia is defined as a group of symptoms, whether related or unrelated to intake, localized in the upper abdomen, that manifest in the form of discomfort or epigastric pain, postprandial fullness and early satiety, in the absence of any demonstrable organic or structural anomaly. The etiopathogenesis and physiopathology of the process are unknown but factors that may be involved include gastric motility disorders, visceral hypersensitivity, psychological and genetic factors, Helicobacter pylori infection, and gastric acid hypersecretion. There is still no etiological treatment and consequently treatment is empirical and based on symptoms. This article reviews the main therapeutic options currently available, with special emphasis on the use of certain phytoceuticals (STW 5), in an attempt to integrate with traditional scientific medicine. This article also proposes an integrative therapeutic algorithm. Copyright © 2013 Elsevier España, S.L. and AEEH y AEG. All rights reserved.

  14. Abnormal duodenal loop demonstrated by X-ray. Correlation to symptoms and prognosis of dyspepsia

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    Thommesen, P.; Funch-Jensen, P.

    1986-01-01

    The occurrence of dyspeptic symptoms has previously been correlated with the shape of the duodenal loop in patients with X-ray-negative dyspepsia. An abnormal duodenal loop was associated with a significantly higher incidence of symtoms provoked by meals, vomiting, regurgitations, heartburn, and the irritable bowel syndrome. 89% of these patients (26 patients with a normal duodenal loop and 39 patients with abnormal duodenal loop) were available for a 5-year follow-up study of symptomatic outcome. The incidence of symptoms provoked by meals was still significantly higher in patients with an abnormal duodenal loop, and there was also a significant difference concerning symptomatic outcome. Approximately 75% of the patients with a normal duodenal loop had improved, and 25% had unchanged clinical conditions. Approximately 50% of the patients with an abnormal duodenal loop had improved, and 50% had an unchanged or even deteriorated clinical condition.

  15. Hangekobokuto (Banxia-houpo-tang, a Kampo Medicine that Treats Functional Dyspepsia

    Directory of Open Access Journals (Sweden)

    Tetsuro Oikawa

    2009-01-01

    Full Text Available Although abdominal bloating is one of the most bothersome symptoms experienced by patients with functional dyspepsia (FD, therapeutic drugs to relieve abdominal bloating have not been established. We investigated the Kampo (Chinese herbal medicine, Hangekobokuto (Banxia-houpo-tang, HKT for patients with FD from the standpoint of bowel gas retention. The bowel gas volume calculated from a plain abdominal radiogram (gas volume score, GVS in FD patients was significantly higher than that in healthy subjects. Two week administration of HKT in the FD patients showed a significant decrease of GVS. Furthermore, gastrointestinal symptoms, especially symptoms of abdominal pain, indigestion and constipation, all of which are closely related to abdominal bloating, improved significantly in FD patients after the administration of HKT. These results suggest that HKT improves abdominal bloating accompanied by the reduction of bowel gas in FD patients.

  16. Helicobacter pylori-associated gastritis and dyspepsia. The influence on migrating motor complexes

    DEFF Research Database (Denmark)

    Qvist, N; Rasmussen, L; Axelsson, C K

    1994-01-01

    Twenty-five patients with dyspepsia were included. In 19 patients with a median age of 48 (range, 20-72) years endoscopy and histologic examination of biopsy specimens from the antrum and corpus of the stomach showed Helicobacter pylori-positive gastritis as the only pathologic finding. In six...... patients with a median age of 42 (range, 32-56) years H. pylori-negative gastritis was found. After an overnight fast the patients underwent an ambulatory duodenal motility study for 6-8 h. Twenty-five young healthy men served as the control group. In patients with H. pylori-positive gastritis the duration...... (22-89 min) in the control group. The duration of phase III and the whole MMC cycle was similar in the two groups. However, in the patients with H. pylori-negative gastritis the values of the duration of the different phases of the MMC were similar to those of the patients with H. pylori...

  17. Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia.

    Science.gov (United States)

    Rathbone, B J; Wyatt, J I; Worsley, B W; Shires, S E; Trejdosiewicz, L K; Heatley, R V; Losowsky, M S

    1986-01-01

    Antibody titres to Campylobacter pyloridis in serum and gastric juice were estimated by an enzyme linked immunosorbent assay (ELISA) to whole organisms obtained from bacterial culture in 39 patients with non-ulcer dyspepsia. Whereas 20 of the 21 patients with chronic gastritis had gastric C pyloridis, 17 patients with no C pyloridis had normal histology in the gastric antrum and body. Significantly raised serum IgG and IgA antibody titres to C pyloridis were found in colonised patients with gastritis. Patients with raised IgG antibody to C pyloridis were also shown to have significantly raised titres to other Campylobacter species, suggesting antigenic cross reactivity. Gastric juice antibodies were also studied and IgA titres to C pyloridis were detected in a proportion of patients with gastritis, together with low levels of IgM, but no IgG. PMID:3721286

  18. Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Craig; A; Friesen; Jennifer; V; Schurman; Jennifer; M; Colombo; Susan; M; Abdel-Rahman

    2013-01-01

    There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining "anti-inflammatory" medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD.

  19. Novas drogas no tratamento da dispepsia funcional New drugs for the treatment of functional dyspepsia

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    Luiz Ernesto de Almeida TRONCON

    2001-09-01

    Full Text Available Racional — A dispepsia funcional caracteriza-se pela ocorrência de sintomas digestivos altos, na ausência de qualquer evidência de doença orgânica ou anormalidade estrutural. O tratamento farmacológico atual desta condição é feito empiricamente com agentes anti-secretores ou drogas pró-cinéticas. Objetivos - Rever os avanços recentes nos conhecimentos sobre os mecanismos responsáveis pelo aparecimento dos sintomas, bem como o desenvolvimento de novas drogas capazes de interferir nestes mecanismos, que abrem a perspectiva de tratamento farmacológico mais racional e efetivo da dispepsia funcional. Método - Revisão sistemática do trabalhos publicados em língua inglesa, nos últimos 10 anos. Resultados - Novas drogas que aumentam a propulsão gastroduodenal incluem: derivados benzamídicos análogos da cisaprida, antagonistas dos receptores A da colecistocinina, agonistas de receptores opióides e uma nova classe de agonistas da motilina, semelhantes à eritromicina. Drogas agonistas dos receptores serotoninérgicos do plexo mioentérico, como o sumatriptano e a buspirona, podem aumentar a capacidade de acomodação do bolo alimentar. Por fim, novas drogas, de grupos farmacológicos diversos, estão sendo avaliadas quanto a sua capacidade de reduzir ou modificar a percepção sensorial visceral. Inclui este grupo a octreotida, a loxiglumida, o ondansetron e seus análogos, a fedotozina e os anti-depressivos tricíclicos, em doses baixas. Conclusões - Ainda que as novas drogas apresentem alto potencial de aperfeiçoar o tratamento da dispepsia funcional, há a necessidade de ensaios controlados, com número adequado de pacientes, para se comprovar a eficácia desses medicamentos. Além disso, as dificuldades em determinar o mecanismo subjacente aos sintomas pode limitar o impacto positivo das novas drogas no tratamento da dispepsia funcional.Background — Functional dyspepsia is defined by upper gastrointestinal symptoms without

  20. Endoscopic and symptoms analysis in Mexican patients with irritable Bowel syndrome, dyspepsia, and gastroesophageal reflux disease

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    Santiago Camacho

    2010-12-01

    Full Text Available The aim of this study was to analyze the data of endoscopy and symptoms in 118 Mexican patients with irritable bowel syndrome (IBS, dyspepsia, non-erosive reflux disease (NERD and erosive esophagitis (EE. IBS criteria were fulfilling for dyspepsia patients in 47%, for NERD in 48%, and for EE patients in 48% of cases. Esophagitis was present in 42% of patients with IBS and in 45% of patients with dyspepsia. A higher prevalence of hiatus hernia was found in EE vs. NERD. Heartburn and acid eructation were associated with the presence of esophagitis; acid eructation, regurgitation and nocturnal pain with duodenitis; and heartburn and regurgitation with hiatus hernia. Males more frequently reported: ucus in feces, abdoinal distension, nausea and gastritis; and oen ore frequently reported esophagitis and duodenitis. Patients with NERD (OR 2.54, 95% CI 1.08 to 5.99, p=0.04, tenesmus and early satiety, and men had an increase risk for reporting hard or lumpy stools. In conclusion, nearly half of the Mexican patients with NERD, EE and dyspepsia fulfill criteria for IBS. A large number of symptoms were correlated with endoscopy, which can be used to improve the indication of the endoscopy and its implementation in clinical studies.O objetivo deste estudo foi analisar os dados de endoscopia e sintomas de 118 pacientes mexicanos com síndrome do intestino irritável (IBS, dispepsia, doença do refluxo não-erosiva (NERD e esofagite erosiva (EE. Os pacientes com IBS preencheram os critérios para dispepsia em 47%, para NERD em 48%, e para pacientes EE em 48% dos casos. Esofagite estava presente em 42% dos pacientes com IBS e em 45% dos pacientes com dispepsia. A maior prevalência de hérnia de hiato foi encontrada na EE em comparação com NERD. Azia e eructação ácida foram associadas à presença de esofagite; eructação ácida, regurgitação e dor noturna, com duodenite; e azia e regurgitação com hérnia de hiato. Os homens relataram mais

  1. Clinical Observation on Xiaoyu Decoction (消郁汤) Plus Psychotherapy in Treating Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To explore the relationship between mental symptoms and functional dyspepsia (FD), and the effect of Xiaoyu decoction (XYD) plus psychotherapy on FD. Methods: SCL-90 scale and FD symptom scale were used to estimate the condition of 56 healthy subjects and 56 patients of FD before and after 4 weeks treatment with XYD plus psychotherapy. Results: There was significant difference in SCL-90 scales between the healthy subjects and the FD patients before treatment (P<0.01). After treatment, the mental symptoms and the symptom of FD in the patients were markedly improved, as compared with those before treatment, the difference was significant (P<0.01). Conclusion: Mental symptoms, such as depression and anxiety existed commonly in FD patients, were closely related to FD. XYD plus psychotherapy could cure it effectively.

  2. Clinical Comparative Study on Massage Therapy and Cisapride in Treating Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jia-fu; LIN Qiang; LIU Hong-bo; ZHOU Ping; XIAO Yuan-chun

    2007-01-01

    To observe the clinical efficacy of massage therapy and Cisapride in the treatment of functional dyspepsia (FD).Methods:Eighty subjects were randomized into two groups:treatment group in which 40 cases were treated by massage therapy and control group in which 40 cases were treated by Cisapride,with a course of 4 weeks;meanwhile,another 40 healthy people were taken as normal group.Abdominal fullness,acid regurgitation,diminished appetite and anorexia,nausea and vomiting and health survey were observed;symptom scores were recorded.Results:These two treatment methods were effective for FD.Conclusion:Mental disorder is one cause of FD;massage therapy is quite effective for it.

  3. The role of psychiatric symptoms, alexithymia, and maladaptive defenses in patients with functional dyspepsia

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    Mahbobeh Faramarzi

    2012-01-01

    Full Text Available Background: Functional dyspepsia (FD is a condition commonly seen in gastroenterological practice. The pathophysiology of FD is likely to be multi-factorial and remains incompletely understood. Although evidence for a psychological etiology is growing, few researches have investigated the role of psychological factors in FD disease. The aim of the study was to assess the role of alexithymia, psychiatric symptoms, and defense mechanism in patients with FD. Materials and Methods: In a case-control study, 60 consecutive with established FD referred to gastroenterology and 60 healthy people matched regarding demographic variables were selected. The subjects filled out three questionnaires; Symptom Checklist-90-Revised 40-item Defense Style and 20-item Toronto Alexithymia Scale. Statistical Analysis: Student′s t-test and multivariate analysis variance model were used to compare the two groups. Results: Significantly higher scores were found in patients with dyspepsia when compared with controls for most psychiatric symptoms (depression P < 0.001, anxiety P < 0.001, obsessive-compulsion P < 0.001, interpersonal sensitivity P < 0.001, psychoticism P < 0.001, hostility P < 0.001, and total score of psychiatric symptoms P < 0.001. Alexithymia symptoms (both (difficulty in identifying feelings and difficulty in describing feelings was higher in FD patients than healthy individuals ( P < 0.001. Also, the use of maladaptive defense mechanisms (both neurotic and immature in FD patients significantly was higher than healthy individuals ( P < 0.001. Conclusion: Psychiatric symptoms, alexithymia, and maladaptive defense play significant role in the emergence of FD symptoms. This study proposes that FD patients should be evaluated and treated by departments of gastroenterology and psychiatry.

  4. Unhealthy dietary behavior in refractory functional dyspepsia: a multicenter prospective investigation in China.

    Science.gov (United States)

    Jiang, Shu Man; Lei, Xiao Gai; Jia, Lin; Xu, Ming; Wang, Sheng Bing; Liu, Jing; Song, Min

    2014-12-01

    To determine the association of dietary behavior with refractory functional dyspepsia (RFD) and its subtypes in Chinese patients. The medical records of patients admitted to the Outpatient Department of Gastroenterology of four hospitals in Mainland China for upper gastrointestinal (GI) symptoms from June to September 2012 were reviewed and their characteristics were collected. Functional dyspepsia (FD) was diagnosed based on the Rome III criteria. RFD was defined as FD with continuous symptoms for at least 6 months that was unresponsive to at least two kinds of medications. Another 100 healthy volunteers were included as controls. The participants' dietary behaviors were investigated using a questionnaire survey. Overall, 1341 FD patients were enrolled in the study, including 327 RFD and 1014 non-RFD (NRFD). Unhealthy dietary behaviors were more prevalent in both RFD and NRFD than in the healthy controls. Skipping meals, eating extra meals and a preference to sweet food and gas-producing food were more common in the RFD patients. Compared with NRFD, RFD-epigastric pain syndrome (EPS) patients preferred spicy food, whereas those with postprandial distress syndrome (PDS) preferred sweet food and gas-producing food, and those with both EPS and PDS were found to skip meals and take extra meals more often. Logistic regression analysis showed that skipping meals, eating extra meals and a preference to sweet food and gas-producing food were risk factors for RFD. Unhealthy dietary behaviors, especially skipping meals, eating extra meals and a preference to sweet food and gas-producing food, were correlated with RFD and its subtypes. © 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

  5. The short-term effects of Helicobacter pylori eradication on symptoms of functional dyspepsia

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    Ayla Tezer

    2010-09-01

    Full Text Available Objectives: Helicobacter pylori (H.pylori infection is major etiologic factor of chronic active gastritis and peptic ulcer disease. Functional dyspepsia (FD is defined as “persistent or recurrent abdominal pain or discomfort centered in the upper abdomen in patient who has no definite structural or biochemical explanation of their symptoms. It is uncertain whether treatment of H.pylori infection relieves symptoms in patients with FD. We searched short term effects of H.pylori eradication for symptoms in patients with FD.Material and method: We enrolled patients with dyspeptic symptoms which were diagnosed FD and satisfied en-rollment criteria of trial. Endoscopic biopsy was taken from each patient during upper gastrointestinal endoscopy. H.pylori infected patients were assigned to seven days of treatment with 30 mgr of lansoprozole twice daily, 1000 mg of amoksisilin twice daily, and 500 mg levofloxacin once daily. Patients were assessed whether treatment was suc-cessful or not by 14C urea breathe test after 6-8 week. Also pretreatment and post treatment symptom scores were questioned.Results: There were 99 female and 68 male patients. After treatment 114 patients (68% was negative for H. pylori, 53 patients (32% remained positive. Mean of age and proportion of sex was similar in H.pylori (+ and (- groups. While 111 (97.4% of H.pylori (- patients’ symptom scores decreased, 38 (71.7% of H.pylori (+ patients’ scores de-creased. There was significant differences between two groups (p=0.001.Conclusion: Eradication of H.pylori relieves the symptoms of functional dyspepsia. New trials for long term effect of H.pylori eradication on symptoms must be conducted in future.

  6. Effect of oral N-acetyl cysteine on eradication of Helicobacter pylori in patients with dyspepsia.

    Science.gov (United States)

    Karbasi, A; Hossein Hosseini, S; Shohrati, M; Amini, M; Najafian, B

    2013-03-01

    Using mucolytic agents that decrease viscosity of the gastric mucous and therefore, increase the permeability of antibiotics through gastric membrane has been offered as an additive treatment to achieve a higher rate of eradication of Helicobacter pylori (H. Pylori) infection. The aim of this study was to determine the efficacy of oral N-acetyl cysteine (NAC) on eradication of H. pylori infections in patients suffering from dyspepsia. In this randomized double-blinded clinical trial, 60 H. pylori positive patients who were suffering from dyspepsia were included. They were divided into two groups. Both groups received three-drug regimen including pantoprazole 40 mg BD, ciprofloxacin 500 mg BD and bismuth subcitrate 120 mg two tablets BD. Experimental group (30 cases) received 600 mg of NAC besides three-drug regimen. Control group received placebo. The results of therapy were tested by 14C-UBT and were compared with each other two months after the first visit. H. pylori infection was eradicated in 21 (70%) and 17 (60.7%) patients in experimental and control groups, respectively (P=0.526). Regarding clinical and endoscopic variables, no significant difference was observed between the two groups except for erosive gastritis (0.041) and erosive esophagitis (0.031). Our findings offer that NAC has an additive effect on H. pylori triple therapy with pantoprazole, ciprofloxacin and bismuth subcitrate. Although NAC does not have any known activity against H. pylori, it can reduce the thickness of the mucus layer and increase the permeability of antibiotics at the site of infection. To evaluate this effect, more studies with larger sample size should be performed.

  7. ENDOSCOPIC AND HISTOPATHOLOGIC CHANGES IN CHILDREN WITH CHRONIC DYSPEPSIA IN A RURAL MEDICAL COLLEGE HOSPITAL IN MELMARUVATHUR- TAMILNADU

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    Padma K

    2016-09-01

    Full Text Available INTRODUCTION Chronic pain abdomen and dyspepsia is the most common presenting symptoms in the Paediatric Outpatient Department (OPD after respiratory illnesses. It is increasing alarmingly both in the paediatric and adult population. We, therefore carried out a cross-sectional study among children with chronic dyspepsia aged between 5 to 15 years attending Paediatric OPD in a rural medical college hospital, Melmaruvathur, Tamilnadu, South India. OBJECTIVE To evaluate the gastroduodenal morbidity in children presenting to the paediatric department of a rural medical college hospital with chronic dyspeptic symptoms. METHODS Forty six children between the age group of 5 to 15 years with chronic dyspeptic symptoms of at least one month duration were evaluated for their symptom profile, epidemiological profile, nutritional status, endoscopic appearance and histopathological changes. Data analysis was done using SPSS version 18. RESULTS Of the 46 children studied, 43% were between the age group of 5-10 years and 70% were female children. Pain abdomen lasting for more than at least one month was the most common finding (93% observed. Other common symptoms in the order of decreasing frequency were early satiety (87%, poor appetite (76%, nausea (57% and not thriving (57%. History of loss of appetite was significantly associated with chronic dyspepsia with an odds ratio of 68.9394 and 95% confidence interval 26.62 to 178.54, p value of <0.0001. Most of the children belonged to lower income group predominantly of a rural background. 33 (72% children had under nutrition as per IAP classification. 10 (30% Grade I, 15 (45% Grade II and eight (24% had Grade III malnutrition. 26 children (57% had abnormal endoscopic findings. Antral mucosal biopsy done showed chronic lymphocytic gastritis in 44 (96% cases. 38 of these 44 (86% were H. pylori positive. H. pylori positivity in chronic dyspepsia was highly statistically significant with a p value of 0

  8. Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: A randomized double-blind placebo-controlled clinical trial.

    Science.gov (United States)

    Khonche, Ahmad; Fallah Huseini, Hasan; Abdi, Hamed; Mohtashami, Reza; Nabati, Farzaneh; Kianbakht, Saeed

    2017-07-12

    Mentha pulegium L. leaves are used in the Iranian traditional medicine for the treatment of functional dyspepsia. To study the efficacy and safety of M. pulegium in the treatment of functional dyspepsia patients fulfilling the Rome III criteria. The efficacy and safety of a standardized Mentha pulegium leaf extract (drug extract ratio: 15.9:1, extraction solvent: 70% v/v aqueous ethanol) (330mg three times daily taken for 2 months) as add-on to one famotidine 40mg tablet per day in the treatment of 50 functional dyspepsia patients were compared with those of a parallel placebo group (n =50). The extract significantly decreased the total dyspepsia score measured by the Hong Kong dyspepsia index compared to the placebo and baseline (P=0.011 and P0.05). The extract improved the quality of life measured by the SF-36 questionnaire significantly compared to the placebo and baseline (P=0.003 and P0.05). The patients did not experience any adverse drug effect. M. pulegium extract (genuine drug extract ratio: 19.4:1; extraction solvent: 70% v/v aqueous ethanol) 270mg three times daily taken for 2 months as adjunct to one famotidine 40mg tablet per day seems safe, improves dyspeptic symptoms and quality of life and eradicates H. pylori in functional dyspepsia patients. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  9. Influence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsia.

    Science.gov (United States)

    Xiao, Mantian; Qiu, Xiaoshan; Yue, Dianchao; Cai, Yongyi; Mo, Qingping

    2013-01-01

    Our aim was to explore in children with functional dyspepsia the effect of hippophae rhamnoides on the levels of plasma appetite factors and on their gastrointestinal motility. A hundred and twenty children with functional dyspepsia were randomly divided into three groups: Group I (treated with hippophae rhamnoides), Group II (treated with domperidone), and Group III (treated with hippophae rhamnoides plus domperidone). The treatment lasted for eight weeks. The levels of plasma leptin (LP) and neuropeptide Y (NPY) were measured before and after treatment. All patients underwent a gastric emptying (GE) test by ultrasound (US) to measure the rate of postprandial gastric antrum residual, at 30min, 60min, 90min and 120min. The average value of subcutaneous fat, body fat percentage, upper arm girth and body mass index (BMI) were also measured. To compare the US with the radionuclide GE test 14 healthy adults volunteers were tested by both GE techniques. We found that the levels of LP and NPY in plasma were markedly higher after treatment in Groups I and III than in Group II. The postprandial gastric antrum remains at 60min, 90min and 120min in Groups I and III fell greatly and the thickness of skin fold (SF), body fat percentage and arm girth increased (P0.05). In conclusion, in children's functional dyspepsia, our study showed that hippophae rhamnoides increases the levels of appetite factors, leptin and neuropeptide Y, increases gastric emptying and gastrointestinal digestive function, children's growth and development.

  10. Efficacy and safety of ecabet sodium on functional dyspepsia :A prospective, double-blinded, randomized, multi-center controlled trial

    Institute of Scientific and Technical Information of China (English)

    Jun Haeng Lee; Soo Teik Lee; Eun Hyun Lee; Jong Chul Rhee; Jae J Kim; Ki-Baik Hahm; Dong Ho Lee; Nayoung Kim; Sung Kook Kim; Jong Jae Park; Seok Reyol Choi; Jong Hun Lee

    2006-01-01

    AIM: To compare ecabet sodium and cimetidine in relieving symptoms of functional dyspepsia.METHODS: We performed a multi-center, prospective,randomized, double-blinded controlled trial to compare the clinical efficacy of ecabet sodium and cimetidine in patients with functional dyspepsia. Two-hundred and seventy-two patients with dyspeptic symptoms fulfilling the Rome-Ⅱ criteria were enrolled from 7 centers. In the study group (115 patients), 1.5 g ecabet sodium was given twice a day. In the control group (121 patients),400 mg cimetidine was given twice a day. Symptoms and parameters of quality of life were analyzed at baseline, 3,14, and 28 d after initiating the treatment.RESULTS: Two-hundred and thirty-six patients completed the clinical trial. After 4 wk of treatment,the rates of improvement in patients with dyspeptic symptoms were not different between two groups (77.4% in the ecabet group and 79.3% in the cimetidine group, respectively, P > 0.05). Likewise, the rates of symptomatic improvement were not different at 3 d and 14 d. The parameters of quality of life did not change significantly during the study period in both groups.There was no clinically significant adverse event in both groups.CONCLUSION: In patients with functional dyspepsia,ecabet sodium has similar clinical efficacy with cimetidine.

  11. Gastroesophageal Reflux Symptoms not Responding to Proton Pump Inhibitor: GERD, NERD, NARD, Esophageal Hypersensitivity or Dyspepsia?

    Directory of Open Access Journals (Sweden)

    Mohammad Bashashati

    2014-01-01

    Full Text Available Gastroesophageal reflux (GER is a common gastrointestinal process that can generate symptoms of heartburn and chest pain. Proton pump inhibitors (PPIs are the gold standard for the treatment of GER; however, a substantial group of GER patients fail to respond to PPIs. In the past, it was believed that acid reflux into the esophagus causes all, or at least the majority, of symptoms attributed to GER, with both erosive esophagitis and nonerosive outcomes. However, with modern testing techniques it has been shown that, in addition to acid reflux, the reflux of nonacid gastric and duodenal contents into the esophagus may also induce GER symptoms. It remains unknown how weakly acidic or alkaline refluxate with a pH similar to a normal diet induces GER symptoms. Esophageal hypersensitivity or functional dyspepsia with superimposed heartburn may be other mechanisms of symptom generation, often completely unrelated to GER. Detailed studies investigating the pathophysiology of esophageal hypersensitivity are not conclusive, and definitions of the various disease states may overlap and are often confusing. The authors aim to clarify the pathophysiology, definition, diagnostic techniques and medical treatment of patients with heartburn symptoms who fail PPI therapy.

  12. The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria

    Directory of Open Access Journals (Sweden)

    LIU SiChun

    2008-09-01

    Full Text Available Abstract Background Epidemiological studies suggest considerable overlap between functional dyspepsia (FD and irritable bowel syndrome (IBS. To date, no surveys have been performed to investigate the clinical overlap between these two disorders using Rome III criteria. Our aim was to investigate the prevalence and risk factors for the overlap of FD and IBS based on Rome III criteria in a large clinical sample. Methods Consecutive patients at the general gastroenterology outpatient clinic were requested to complete a self-report questionnaire. FD and IBS were defined by Rome III criteria. Results Questionnaires were returned by 3014 patients (52.8% female, 89% response rate. FD-IBS overlap was observed in 5.0% of the patients, while 15.2% and 10.9% of the patients were classified as FD alone and IBS alone, respectively. Compared with non-IBS patients, the odds ratio of having FD among IBS patients was 2.09 (95% CI: 1.68–2.59. Patients with FD-IBS overlap had higher severity scores for the postprandial fullness symptom (2.35 ± 1.49 vs. 1.72 ± 1.59, P Conclusion Clinical overlap of FD and IBS according to Rome III criteria is very common. One risk factor for FD-IBS overlap is the presence of postprandial fullness symptom. This study provides clues for future pathophysiological studies of FD and IBS.

  13. Clinicohistopathological correlation and Helicobacter pylori status in patients with functional dyspepsia

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    Anita Basavaraj

    2017-01-01

    Full Text Available Background: Functional dyspepsia (FD is a condition of immense clinical significance. Helicobacter pylori may be responsible for FD in a subset of patients. Materials and Methods: Upper gastrointestinal endoscopy was done in sixty patients of FD fulfilling ROME III criteria, and gastric and duodenal biopsies were taken. Duodenal histopathological findings and H. pylori status were correlated with the symptomatology. Standard treatment was given according to the H. pylori status, and the response was analyzed using 6-point Likert scale. Results: Sixty percent of cases were infected with H. pylori. 72.5% of cases with predominant epigastric pain were H. pylori-positive. 96.5% patients with early satiety had duodenal eosinophilia and duodenitis. Epigastric pain was significantly associated with H. pylori, and early satiety was associated with duodenal eosinophilia and duodenitis. Sixty-five percent of cases had increased duodenal intraepithelial lymphocyte count. 88.8% cases showing no response to treatment had duodenal eosinophilia. Conclusion: H. pylori infection constitutes an important subset of FD patients. H. pylori infection, duodenitis, and duodenal eosinophilia contribute to symptom generation. H. pylori eradication can provide symptomatic relief. A duodenal biopsy can identify an important subset of patients with duodenal eosinophilia and duodenitis which can be a contributor for poor treatment response and can be clinically amenable to new treatment avenues.

  14. Psychological distress in Rome III functional dyspepsia patients presenting for testing of gastric emptying.

    Science.gov (United States)

    Dibaise, J K; Islam, R S; Dueck, A C; Roarke, M C; Crowell, M D

    2016-02-01

    There have been conflicting results from studies that have evaluated psychological disturbances in functional dyspepsia (FD). We conducted a comprehensive survey of psychological measures in patients undergoing gastric emptying testing (GET) in order to determine the relationship among psychological distress, gastric emptying, and dyspeptic symptoms. Consecutive patients referred for GET were prospectively enrolled. Details regarding patient characteristics, health care utilization, dyspeptic symptoms, quality of life, and psychological dysfunction were obtained. Depression, anxiety, somatization, stress, positive and negative affect, and alexithymia were queried using validated questionnaires. We compared those dyspeptic patients who met Rome III criteria for FD to those who did not meet these criteria. Two hundred and nine patients (160 female; mean age 46.6 years ± 17.3 years) participated. Around 151 patients (72%) met Rome III criteria for FD. In the entire group, a high level of depression, anxiety, somatization, and perceived stress was present compared to population norms. Health care seeking behavior and symptom severity were greater in those with FD and quality of life was lower compared to non-FD. Gastric emptying did not differentiate the two groups and similar degrees of psychological distress were present whether emptying was delayed or normal. In patients referred for GET, substantial psychological distress is present. The degree of distress was similar regardless of whether the patient met Rome III FD criteria or not. Further evaluation of psychological dysfunction in FD patients may lead to improved diagnosis and determination of the most appropriate treatment. © 2015 John Wiley & Sons Ltd.

  15. The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria.

    Science.gov (United States)

    Wang, Anjiang; Liao, XianHua; Xiong, LiShou; Peng, Sui; Xiao, YingLian; Liu, SiChun; Hu, PinJin; Chen, MinHu

    2008-09-23

    Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). To date, no surveys have been performed to investigate the clinical overlap between these two disorders using Rome III criteria. Our aim was to investigate the prevalence and risk factors for the overlap of FD and IBS based on Rome III criteria in a large clinical sample. Consecutive patients at the general gastroenterology outpatient clinic were requested to complete a self-report questionnaire. FD and IBS were defined by Rome III criteria. Questionnaires were returned by 3014 patients (52.8% female, 89% response rate). FD-IBS overlap was observed in 5.0% of the patients, while 15.2% and 10.9% of the patients were classified as FD alone and IBS alone, respectively. Compared with non-IBS patients, the odds ratio of having FD among IBS patients was 2.09 (95% CI: 1.68-2.59). Patients with FD-IBS overlap had higher severity scores for the postprandial fullness symptom (2.35 +/- 1.49 vs. 1.72 +/- 1.59, P Rome III criteria is very common. One risk factor for FD-IBS overlap is the presence of postprandial fullness symptom. This study provides clues for future pathophysiological studies of FD and IBS.

  16. ghrelin与功能性消化不良%Ghrelin and functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    蔡顺天; 王巍峰

    2011-01-01

    Though there are no evidences of organic change in patients with functional dyspepsia (FD), abnormalities of gastric emptying, dysregulation of gastroduodenal motility, and visceral hypersensitivity are often present in FD.Ghrelin is one kind of brain-gut peptide mainly secreted by gastric X/A-like cell. As it affects gastric motility, emptying and secretion, this peptide may play a pathophysiological role in FD. Recently, plasma ghrelin level is reported to be altered in FD, which indicates further investigations are needed.%功能性消化不良(FD)患者尽管未发现胃肠道器质性病变,但是研究提示FD可能存在胃动力、胃排空、胃十二指肠神经调节或内脏敏感性等胃肠道功能的改变.ghrelin作为主要由胃X/A样细胞产生的一种多肽,影响胃的动力、排空和分泌功能.最近的研究表明血清中的ghrelin水平与FD有一定的关系,提示其可能在FD的发病机制中起一定的作用,值得深入的研究.

  17. Comparison of psychiatric morbidity in patients with irritable bowel syndrome and non-ulcer dyspepsia

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    Susanta Kumar Padhy

    2016-01-01

    Full Text Available Background and Aims: The present study aimed to find psychiatric morbidity, stress, anxiety, and depression in patients with irritable bowel syndrome (IBS and compare it with patients having non-ulcer dyspepsia (NUD. Methods: This case NUD study compared 50 patients each with IBS and NUD. The two groups were compared on demographic data, psychiatric diagnosis using the Structured Clinical Interview for DSM-IV Axis 1 disorders, anxiety levels using the Hamilton Anxiety Rating Scale (HAM-A, and depression using the Hamilton Depression Rating Scale (HAM-D. The Presumptive Stressful Life Events Scale (PSLES was used to measure stress. Results: The cases of IBS were more likely to be of female gender (P = 0.012, married (P = 0.009, and employed (P < 0.001. Psychiatric diagnoses were more common in the cases of IBS than NUDs (88% vs. 30%, P< 0.001, the most common being major depression and somatization disorder. Symptoms of anxiety and depression were more common in patients with IBS (P < 0.001 for HAM-A and HAM-D. Logistic regression revealed that having IBS and increased age were independent predictors of having a psychiatric diagnosis. Conclusions: IBS is associated with the considerable degree of psychiatric morbidity. Adequate attention should be paid toward comorbid psychiatric illnesses, and prompt treatment should be instituted.

  18. Cognitive emotion regulation strategies in patients with functional dyspepsia and healthy controls - A comparative study.

    Science.gov (United States)

    Mazaheri, Mina; Afshar, Hamid; Nikneshan, Shekoufeh; Adibi, Peyman

    2016-01-01

    Patients with functional dyspepsia (FD) may use specific coping strategies. Hence, the aim of the present study was to compare cognitive emotion regulation strategies in FD patients and healthy controls. This was a descriptive observational study. The sample consisted of 86 individuals, 43 of whom were patients diagnosed with FD. The patients referred to the psychosomatic disorders clinic, Isfahan, Iran. The comparative sample included 43 healthy controls (without digestive diagnoses) matched with the patients by age and gender. Subjects completed data on demographic factors and cognitive emotion regulation questionnaire. The results indicated that there are significant differences between patients with FD and healthy controls according to using cognitive strategies. Scores of healthy controls in positive reappraisal and acceptance were significantly more than FD patients, and inversely, scores of FD patients in rumination and other-blame were meaningfully more than healthy controls. FD patients apply less adaptive strategies and more maladaptive strategies. It is seemed psychological interventions that focus on reducing maladaptive strategies and increasing adaptive strategies could be effective for FD patients.

  19. Availability of Tongue Diagnosis System for Assessing Tongue Coating Thickness in Patients with Functional Dyspepsia

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    Juyeon Kim

    2013-01-01

    Full Text Available Tongue diagnosis is an important procedure in traditional Korean medicine (TKM. In particular, tongue coating thickness (TCT is deemed to show the progression of the disease. However, conventional tongue diagnosis has limitations because of various external factors. Therefore, it is necessary to investigate the availability of tongue diagnosis system (TDS in the assessment of TCT. This study has been designed as a prospective clinical trial involving 60 patients with functional dyspepsia. Tongue images will be obtained by TDS twice with a 30 min interval. The system will measure the percentage of TCT and classify it as either no coating, thin coating, or thick coating according to the existing diagnostic criteria. After finishing the collection of 60 patients' tongue images, TCT on the images will be simultaneously evaluated by the conventional method to establish the gold standard for assessing TCT by 5 well-trained clinicians. The evaluation will be repeated by the same clinicians after 2 weeks, but the order of the images will be changed. This trial is expected to provide clinical evidence for the availability of TDS as a diagnostic tool and to contribute to the standardization of the diagnosis system used in TKM. This trial is registered with ClinicalTrials.gov NCT01864837.

  20. Functional dyspepsia (FD) and non-erosive reflux disease (NERD): overlapping or discrete entities?

    LENUS (Irish Health Repository)

    Quigley, Eamonn M M

    2012-02-03

    As the incidence of both gastric cancer and peptic ulcer disease have declined, that of gastro-oesophageal reflux disease (GORD) and non-ulcer, or functional dyspepsia (FD) have reached virtually epidemic proportions. As we come to appreciate the expression of these disorders in the community, the real spectrum of each disease has become evident. FD and non-erosive reflux disease (NERD), the most prevalent manifestation of GORD, frequently overlap. Where then does GORD end and FD begin? Is it realistic, or even clinically relevant, to attempt a clear separation between these entities? These are more than issues of mere semantics; therapeutic options may be dictated by the classification of the patient as one or the other. Recent work indicates clearly that NERD is a heterogeneous disorder incorporating some patients who may well harbour subtle manifestations of oesophagitis and others who have entirely normal 24-hour pH studies. These differences may be crucial to the concept of NERD\\/FD overlap. While evidence in support of this concept is far from complete, it would appear that this overlap is most relevant to those NERD patients who do not exhibit abnormal esophageal acid exposure. These patients truly belong in the spectrum of functional gastrointestinal disorders rather than in GORD; attempts to shoe-horn these individuals into the spectrum of GORD will result in therapeutic disappointment and surgical disaster.

  1. Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey

    Institute of Scientific and Technical Information of China (English)

    Ender Serin; U()ur Yilmaz; Ganiye Künefeci; Birol Ozer; Yüksel Gümürdülü; Mustafa Güclü; Fazilet Kayaselcuk; Sedat Boyacio( )lu

    2003-01-01

    AIM: To investigate and compare frequencies of serum positive cagA in patients from two separate regions of Turkey who were grouped according to the presence of peptic ulcer disease or non-ulcer dyspepsia.METHODS: One hundred and eighty Helicobacter pyloripositive patients with peptic ulcer disease or non-ulcer dyspepsia were included in the study. One hundred and fourteen patients had non-ulcer dyspepsia and 66 had peptic ulcer disease (32 with gastric ulcers and/or erosions and 34with duodenal ulcers). Each patient was tested for serum antibody to H. pylori cagA protein by enzyme immunoassay.RESULTS: The total frequency of serum positive cagA in the study group was 97.2 %. The rates in the patients with peptic ulcers and in those with non-ulcer dyspepsia were 100% and 95.6%, respectively. These results were similar to those reported in Asian studies, but higher than those that have been noted in other studies from Turkey and Western countries.CONCLUSION: The high rates of serum positive cagA in these patients with peptic ulcer disease and non-ulcer dyspepsia were similar to results reported in Asia. The fact that there was high seroum prevalence regardless of ulcer status suggests that factors other than cagA might be responsible for ulceration or other types of severe pathology in H. pylori-positive individuals.

  2. Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study

    Institute of Scientific and Technical Information of China (English)

    Victoria PY Tan; Tin K Cheung; Wai M Wong; Roberta Pang; Benjamin CY Wong

    2012-01-01

    AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiaryhospital patients with a clinical diagnosis of functional dyspepsia (FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index (HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacterpylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression (HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat (ITT),and 150 patients were included in the per protocol (PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study (22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4 (95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4 (57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ±5.89,P =0.433; and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P =0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25

  3. The Prevalence of Occult Celiac Disease among Patients with Functional Dyspepsia: A Study from the Western Region of Iran

    Directory of Open Access Journals (Sweden)

    Ali Asghar Keshavarz

    2010-01-01

    Full Text Available Objective. The prevalence of Celiac Disease (CD is high in Iran, and evaluation of CD is not part of the routine screening procedure for dyspeptic patients; therefore, cases of occult CD may be missed. This study aimed to investigate the prevalence of occult CD among dyspeptic patients who presented at a gastroenterology clinic in the Western region of Iran. Methods. In this descriptive, cross-sectional prospective study, patients who had a history of at least 12 weeks of upper abdominal discomfort were eligible to participate in the study during a 14-month recruitment period. Patients with a clinical or paraclinical data in favor of organic causes were excluded from the study. Enrolled patients were screened for IgA antiendomysium antibody (EMA and IgA antitissue transglutaminase antibody (tTG. Those who screened positive for EMA/tTG received a confirmatory diagnostic biopsy for Marsh classification of CD. Results. From 225 potential participants with dyspepsia, 55 patients were excluded due to having explainable organic causes. The study sample included 170 patients with “functional dyspepsia.” Mean age of participants was 31 years and 55.8% were female. Twelve patients (7% had positive tests (EMA/tTG, of which 10 were female (83.4%. According to Rome II criteria, all twelve patients with positive tests had “dysmotility type dyspepsia.” Based on Marsh classification, six patients were consistent with “Marsh I,” four with “Marsh II,” and two with the “Marsh III” classification. Conclusions. In this study, the prevalence of CD in dyspeptic patients was high. As a result, this study suggests that screening by serology tests (EMA/tTG is justifiable for the detection of CD among functional dyspeptic patients in the tertiary centers in our country.

  4. Therapeutic efficacy of digital music gastric electrical pacing for refractory functional dyspepsia concomitant with non-erosive reflux disease

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    Ya-mei RAN

    2015-04-01

    Full Text Available Objective To study the clinical efficacy of digital music gastric electrical pacing for refractory functional dyspepsia concomitant with non-erosive reflux disease, and its effects on mental health and life-quality of the patients. Methods According to the Rome Ⅲ criteria and Montreal consensus in diagnosis of gastroesophageal reflux disease, 50 patients with concomitant refractory functional dyspepsia and non-erosive reflux disease were recruited. The clinical efficacy of digital music gastric electrical pacing were evaluated using the score of clinical symptoms before treatment and 15 days after treatment, and the mental health and life-quality of patients were assessed using symptom checklist 90. Results Main symptoms, including upper abdominal pain, abdominal fullness, early satiety, belching, hiccup, nausea, heartburn, acid reflux (daytime, nocturnal acid reflux, loss of appetite and sleep, were significantly improved 15 days after treatment compared with those of pre-treatment, and there were statistically significant differences (all P<0.005. The significant response rate/response rate (efficacy rate were 59.0%/100.0%, 59.3%/96.3%, 47.0%/94.1%, 61.3%/96.8 %, 86.7%/100.0%, 80.0%/100.0%, 64.3%/92.9%, 73.7%/89.5%, 64.3%/85.7%, 90.0%/90.0%, 36.7%/93.3% respectively. After treatment for 15 days, the overall response rate of symptom relief was 94.4% in patients and the overall significant response rate was 65.7%. The symptom scores of somatization, obsessive-compulsiveness, depression, and anxiety were significantly improved, and the differences were statistically significant (all P<0.01. Conclusion The clinical efficacy of digital music gastric electrical pacing is significant for refractory functional dyspepsia concomitant with nonerosive reflux disease, and it is expected to be a new option for the treatment of this disease complex. DOI: 10.11855/j.issn.0577-7402.2015.03.08

  5. Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole - results from the STARS II study

    DEFF Research Database (Denmark)

    Veldhuyzen van Zanten, S; Wahlqvist, P; Talley, N J

    2011-01-01

    . Methods  Patients (n = 1250) with uninvestigated dyspepsia (no endoscopy within 6 months and ≤2 endoscopies within 10 years) underwent a 1-week esomeprazole acid-suppression test before randomisation to 7 weeks' esomeprazole or placebo. The Reflux Disease Questionnaire (RDQ), Quality of Life in Reflux...... dyspepsia domain, and the highest disease burden was for QOLRAD vitality and food/drink problems. After 8 weeks, significant improvements vs. placebo were observed for all RDQ and QOLRAD domains. The sub-population of acid-suppression test responders, but not the total WPAI population, had a significant...

  6. Draft genome sequences of Helicobacter pylori isolates from Malaysia, cultured from patients with functional dyspepsia and gastric cancer.

    Science.gov (United States)

    Gunaletchumy, Selva Perumal; Teh, Xinsheng; Khosravi, Yalda; Ramli, Nur Siti Khadijah; Chua, Eng Guan; Kavitha, Thevakumar; Mason, Joanne N; Lee, Huey Tyng; Alias, Halimah; Zaidan, Nur Zafirah; Yassin, Norzawani Buang M; Tay, Liang Chung; Rudd, Stephen; Mitchell, Hazel M; Kaakoush, Nadeem O; Loke, Mun Fai; Goh, Khean Lee; Vadivelu, Jamuna

    2012-10-01

    Helicobacter pylori is the main bacterial causative agent of gastroduodenal disorders and a risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The draft genomes of 10 closely related H. pylori isolates from the multiracial Malaysian population will provide an insight into the genetic diversity of isolates in Southeast Asia. These isolates were cultured from gastric biopsy samples from patients with functional dyspepsia and gastric cancer. The availability of this genomic information will provide an opportunity for examining the evolution and population structure of H. pylori isolates from Southeast Asia, where the East meets the West.

  7. Dispepsia funcional e depressão como fator associado Functional dyspepsia and depression as an associated factor

    Directory of Open Access Journals (Sweden)

    Renato Azevedo da Silva

    2006-12-01

    Full Text Available OBJETIVO: Avaliar a associação entre depressão e dispepsia funcional. PACIENTES E MÉTODOS: Estudo transversal onde foram avaliados 348 pacientes com diagnóstico de dispepsia no Ambulatório de Gastroenterologia do Hospital Universitário de Pelotas, RS, cidade de médio porte do sul do Brasil, durante o período de 1 ano (de março de 2001 a março de 2002. Após o diagnóstico de dispepsia avaliou-se a presença de depressão, tanto em pacientes com dispepsia funcional, quanto naqueles com dispepsia orgânica. Utilizou-se a análise univariada para descrição das freqüências das variáveis de interesse e da análise bivariada, com o teste qui-quadrado, para comparação entre proporções das variáveis categóricas. A técnica da regressão logística foi utilizada para estabelecer a chance dos pacientes com depressão apresentarem dispepsia funcional e para controlar o efeito das variáveis intervenientes sobre a variável de desfecho RESULTADOS: Evidenciaram maior prevalência de deprimidos entre os pacientes com dispepsia funcional (30,4% em relação àqueles com dispepsia orgânica (11,2%. As mulheres apresentaram maior chance de dispepsia funcional (OR: 1,74, IC 95%, 1,05-2,89 e, em relação à idade, os intervalos entre 31 e 50 anos (OR: 0,28 IC 95%, 0,13-0,54 e de 51 a 60 anos (OR: 0,41, IC 95%, 0,17-0,96 mostraram efeito protetor, ou seja, indivíduos nessas faixas etárias têm menor risco de apresentar dispepsia funcional. Após a análise multivariada, pacientes deprimidos apresentaram chance três vezes maior de co-morbidade com dispepsia funcional do que pacientes não-deprimidos (OR 3,13; IC 95%; 1,71-5,74.AIM: To assess the association between depression and functional dyspepsia. PATIENTS AND METHODS: Three hundred and forty eight dyspeptic patients were included in a cross-sectional study in the gastroenterology outpatient clinic of a University Hospital in southern Brazil (Pelotas, RS within a 1-year period (from

  8. ASSESSMENT OF PATTERN OF ANTIMICROBIAL RESISTANCE OF HELICOBACTER PYLORI IN PATIENTS OF DYSPEPSIA OF RURAL AREA

    Directory of Open Access Journals (Sweden)

    Yogendra

    2015-08-01

    Full Text Available BACKGROUND : Helicobacter Pylori is a gastric pathogen that chronically infects more than half of the world's population. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa - associated lymphoid tissue lymphoma. Helicobacter pylori eradication rate varies in different parts of the world. This may be related to the regional difference in anti - microbial resistance that affects the outcome of therapy, genetic difference in the metabolism of the proton pump inhibitor, which can also alter the availability of anti - microbial in the stomach. The pattern of antimicrobial resistant of Helicobacter pylori has not been tested in this part of central India. In present study we have assessed the pattern of anti - microbial resistance of Helicobacter Pylori in patients of dyspepsia attending medicine opd , Department of Medicine, Dr. BRAM Hospital, Raipur (Chhattisgarh, India. METHODS: The present study was conducted in the Department of Medicine, Pt . J. N. M. Medical College, and Dr . BRAM Hospital Raipur (C.G. 60 patients attending medicine opd were subjected to upper gastrointestinal endoscopy. Multiple biopsy specimens taken from the gastric antrum. Rapid urease test were done. The biopsy specimen was inoculated in to culture media. The strains were subjected to antibiotic sensitivity test by disk diffusion method for metronidazole, tinidazole, Ornidazole, Clarithromycin, amoxicillin, tetracycline, furazolidone, ofloxacin and ciprofl oxacin. RESULT : The antibiotic resistance of H. Pylori in culture positive cases in our study showed 84.6%o of cases were resistant to Metronidazole, 38.5% to Tinidazole, 7.6%o to Ornidazole, 32.8% to Amoxicillin, 3.8% to Tetracycline, 19.2% to Clarithromycin, 11.5% to furazolidone, and 3

  9. Comparison of Sequential Regimen and Standard Therapy for Helicobacter pylori Eradication in Patients with Dyspepsia

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    Gh. Roshanaei

    2013-10-01

    Full Text Available Introduction & Objective: Some studies have reported successful eradication rates using se-quential therapy but more recent studies performed in Asia did not find a similar benefit. Due to inconsistencies in the comparison of standard triple drugs therapy and sequential regimen, in the previous researches we decided to compare these treatments in Persian patients. Materials & Methods: This study is a randomized clinical trial, performed in one hundred and forty patients suffering from dyspepsia with indication for H. pylori eradication between No-vember 2010 and March 2012.Patients were randomized in two equal groups. The patients in the first group (standard were treated by omeprazole capsule 20 mg BID, amoxicillin cap-sule 1 gr BID, clarithromycin tablet 500mg BID for 14 days; while the patients in the second group (sequential were treated by omeprazole capsule 20 mg for 10 days, amoxicillin cap-sule 1 gr BID for 5 days, then clarithromycin tablet 500 mg and tinidazole tablet 500 mg BID for other 5 days. 4-6 weeks after the treatment, we compared the eradication of H.pylori be-tween the two groups by urease breathe test with C14. Results: H. pylori infection was successfully cured in 57/70 (81.43% with a 10-day sequen-tial therapy, in 60/70 (85.75% with the standard fourteen-day triple therapy, respectively. Conclusion: We detected no significant differences between the 10-day sequential eradication therapy for H. pylori and 14-day standard triple treatment among the patients. (Sci J Hamadan Univ Med Sci 2013; 20 (3:184-193

  10. Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial

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    S Ashraffodin Ghoshegir

    2015-01-01

    Full Text Available Background: We aimed to evaluate the effects of Pimpinella anisum (anise from Apiaceae family on relieving the symptoms of postprandial distress syndrome (PDS in this double-blind randomized clinical trial. Materials and Methods: Totally, 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria and signed a written consent form were enrolled. They were randomized to receive either anise or placebo, blindly, for 4 weeks. Anise group included 47 patients and received anise powders, 3 g after each meal (3 times/day. Control group involved 60 patients and received placebo powders (corn starch, 3 gafter each meal (3 times/day. The severity of Functional dyspepsia (FD symptoms was assessed by FD severity scale. Assessments were done at baseline and by the end of weeks 2, 4 and 12. Mean scores of severity of FD symptoms and the frequency distribution of patients across the study period were compared. Results: The age, sex, body mass index, smoking history, and coffee drinking pattern of the intervention and control groups were not significantly different. Mean (standard deviation total scores of FD severity scale before intervention in the anise and control groups were 10.6 (4.1 and 10.96 (4.1, respectively (P = 0.6. They were 7.04 (4.1 and 12.30 (4.3 by week 2, respectively (P = 0.0001, 2.44 (4.2 and 13.05 (5.2 by week 4, respectively (P = 0.0001, and 1.08 (3.8 and 13.30 (6.2 by week 12, respectively (P = 0.0001. Conclusion: This study showed the effectiveness of anise in relieving the symptoms of postpartum depression. The findings were consistent across the study period at weeks 2, 4 and 12.

  11. Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population

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    Matsumoto Takayuki

    2011-06-01

    Full Text Available Abstract Background Although familial clustering of functional dyspepsia (FD has been reported, the role of genetics in the susceptibility to FD is still not well understood. In the present study, the association between serotonin transporter (SERT gene (SLC6A4 polymorphism and FD was explored. Methods Subjects were divided into either a postprandial distress syndrome (PDS group or an epigastric pain syndrome (EPS group according to the Rome III criteria. The healthy controls were those who had visited a hospital for an annual health check-up. The presence of the SLC6A4 promoter polymorphism, 5-hydroxytryptamin transporter gene linked polymorphic region (5-HTTLPR, was then evaluated, and logistic regression analysis was used to test all variables. Results The 5-HTTLPR genotype distribution was 448 SS, 174 SL, and 24 LL in controls and 30 SS, 20 SL, and 3 LL in FD subjects. No significant correlation was found between the 5-HTTLPR genotype and FD. When the genotypes and subtypes of FD were exploratory evaluated, the SL genotype was significantly associated with PDS [odds ratio (OR = 2.24, 95% confidence interval (CI; 1.16-4.32, P = 0.034 after Bonferroni correction] compared to the SS genotype adjusted for sex and age. Comparison of the SS genotype with the SL/LL genotype also showed a significant association of genotype with PDS (OR = 2.32, 95% CI; 1.23-4.37, P = 0.009. Conclusion The present results suggest that 5-HTTLPR L allele may influence the susceptibility to PDS.

  12. Symptom-based tendencies of Helicobacter pylori eradication in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Ling Lan; Jing Yu; Yu-Long Chen; Ya-Li Zhong; Hao Zhang; Chang-He Jia; Yuan Yuan; Bo-Wei Liu

    2011-01-01

    AIM: To investigate whether there were symptombased tendencies in the Helicobacter pylori (H. pylori ) eradication in functional dyspepsia (FD) patients. METHODS: A randomized, single-blind, placebo-controlled study of H. pylori eradication for FD was conducted. A total of 195 FD patients with H. pylori infection were divided into two groups: 98 patients in the treatment group were treated with rabeprazole 10 mg twice daily for 2 wk, amoxicillin 1.0 g and clarithromycin 0.5 g twice daily for 1 wk; 97 patients in the placebo group were given placebos as control. Symptoms of FD, such as postprandial fullness, early satiety, nausea, belching, epigastric pain and epigastric burning, were assessed 3 mo after H. pylori eradication. RESULTS: By per-protocol analysis in patients with successful H. pylori eradication, higher effective rates of 77.2% and 82% were achieved in the patients with epigastric pain and epigastric burning than those in the placebo group (P 0.05). In 84 patients who received H. pylori eradication therapy, the effective rates for epigastric pain (73.8%) and epigastric burning (80.7%) were higher than those in the placebo group (P 0.05). By intention-to-treat analysis, patients with epigastric pain and epigastric burning in the treatment group achieved higher effective rates of 60.8% and 65.7% than the placebo group (33.3% and 31.8%) (P 0.05). CONCLUSION: The efficacy of H. pylori eradication has symptom-based tendencies in FD patients. It may be effective in the subgroup of FD patients with epigastric pain syndrome.

  13. Temperature can influence gastric accommodation and sensitivity in functional dyspepsia with epigastric pain syndrome.

    Science.gov (United States)

    Wang, Rui-Feng; Wang, Zhi-Feng; Ke, Mei-Yun; Fang, Xiu-Cai; Sun, Xiao-Hong; Zhu, Li-Ming; Zhang, Jing

    2013-09-01

    Functional dyspepsia-epigastric pain syndrome (FD-EPS) is characterized pathophysiologically by visceral hypersensitivity, but the effect of the temperature stimulation on gastric function has been seldom studied. The purpose of this study was to investigate the effects of liquid nutrients at different temperatures on the gastric accommodation, sensitivity, and gastric-wall compliance of healthy subjects (HS) and FD-EPS patients. Ten FD-EPS patients (Roma III criteria) and ten HS were recruited into the study. Intragastric pressure (IGP) and gastric perfusion were measured and compared following the administration of liquid nutrients at 37 °C on day 1 and at 8 °C on day 2. Seven patients developed abdominal discomfort or abdominal pain after being given cold liquid nutrient. The administration of liquid nutrient at 8 °C resulted in an increase of IGP in HS (P=0.044), a significant decrease in gastric perfusion (PIGP (P=0.015), and a dramatic reduction in gastric wall compliance (P=0.012) in patients compared to the effects of liquid nutrient at 37 °C. In addition, IGP in patients was lower than that in HS at 37 °C liquid nutrient (P=0.036), and the gastric perfusion volume in patients at maximal satiety was also significantly reduced at 8 °C liquid nutrient compared with HS (P=0.017). Cold stimulation can increase the IGP in HS and FD-EPS patients, elevate the visceral sensitivity and reduce the gastric volume of FD-EPS patients. FD-EPS patients who are sensitive to cold may develop epigastric discomfort or pain.

  14. Effects of Helicobacter pylori infection on gastric emptying rate in patients with non-ulcer dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Grigoris I Leontiadis; George I Minopoulos; Efstratios Maltezos; Stamatia Kotsiou; Konstantinos I Manolas; Konstantinos Simopoulos; Dimitrios Hatseras

    2004-01-01

    AIM: The pathogenesis of delayed gastric emptying in patients with non-ulcer dyspepsia (NUD) remains unclear.We aimed to examine whether gastric emptying rate in NUD patients was associated with Helicobacter pylori(H pylori)infection and whether it was affected by eradication of the infection.METHODS: Gastric emptying rate of a mixed solid-liquid meal was assessed by the paracetamol absorption method in NUD patients and asymptomatic controls (n=17). H pylori status was assessed by serology and biopsy urease test.H pylori-positive NUD patients (n=23) received 10-day triple eradication therapy. H pylori status was re-assessed by biopsy urease test four weeks later, and if eradication was confirmed, gastric emptying rate was re-evaluated.RESULTS: Thirty-three NUD patients and 17 controls were evaluated. NUD patients had significantly delayed gastric emptying compared with controls. The mean maximum plasma paracetamol concentration divided by body mass (P=0.02), the mean area under plasma paracetamol concentration-time curve divided by body mass (AUC/BM)Gastric emptying rate did not differ significantly between H pylori-positive and H pylori-negative NUD patients. The were initially H pylori-positive, confirmed eradication of the infection did not significantly alter gastric emptying rate.and after Hp eradication, respectively (P=0.64), the mean eradication, respectively (P=0.93).CONCLUSION: Although gastdc emptying is delayed in NUD patients compared with controls, gastric emptying rate is not associated with H pylori status nor it is affected by eradication of the infection.

  15. Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial

    Science.gov (United States)

    Ghoshegir, S. Ashraffodin; Mazaheri, Mohammad; Ghannadi, Alireza; Feizi, Awat; Babaeian, Mahmoud; Tanhaee, Maryam; Karimi, Mehrdad; Adibi, Peyman

    2015-01-01

    Background: We aimed to evaluate the effects of Pimpinella anisum (anise) from Apiaceae family on relieving the symptoms of postprandial distress syndrome (PDS) in this double-blind randomized clinical trial. Materials and Methods: Totally, 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria and signed a written consent form were enrolled. They were randomized to receive either anise or placebo, blindly, for 4 weeks. Anise group included 47 patients and received anise powders, 3 g after each meal (3 times/day). Control group involved 60 patients and received placebo powders (corn starch), 3 gafter each meal (3 times/day). The severity of Functional dyspepsia (FD) symptoms was assessed by FD severity scale. Assessments were done at baseline and by the end of weeks 2, 4 and 12. Mean scores of severity of FD symptoms and the frequency distribution of patients across the study period were compared. Results: The age, sex, body mass index, smoking history, and coffee drinking pattern of the intervention and control groups were not significantly different. Mean (standard deviation) total scores of FD severity scale before intervention in the anise and control groups were 10.6 (4.1) and 10.96 (4.1), respectively (P = 0.6). They were 7.04 (4.1) and 12.30 (4.3) by week 2, respectively (P = 0.0001), 2.44 (4.2) and 13.05 (5.2) by week 4, respectively (P = 0.0001), and 1.08 (3.8) and 13.30 (6.2) by week 12, respectively (P = 0.0001). Conclusion: This study showed the effectiveness of anise in relieving the symptoms of postpartum depression. The findings were consistent across the study period at weeks 2, 4 and 12. PMID:25767516

  16. Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Cezary Chojnacki; Tomasz Poplawski; Gra(z)yna Klupinska; Janusz Blasiak; Jan Chojnacki; Russel J Reiter

    2011-01-01

    AIM: To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD). METHODS: Ninety individuals were enrolled in the study: 30 in each study group: patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and controls. Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: Serum melatonin concentration at night and in the morning was significantly (P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL, quartile range (QR): 79.8-116.2; at 09.00 h-14.3 pg/mL, QR: 7.06-19.0] than in EPS (57.2 pg/mL, QR: 42.6-73.1; 8.1 pg/mL, QR: 4.1-9.3) and control patients (57.7 pg/mL, QR: 51.2-62.5; 8.1 pg/mL, QR: 5.4-10.3). A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms. CONCLUSION: Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.

  17. The effects of helicobacter pylori eradication on modification of metabolic syndrome parameters in patients with functional dyspepsia.

    Science.gov (United States)

    Mokhtare, Marjan; Mirfakhraee, Hosna; Arshad, Mahmoud; Samadani Fard, Seyed Hossein; Bahardoust, Mansour; Movahed, Alireza; Masoodi, Mohsen

    2017-07-27

    Helicobactor pylori (H. pylori) have the potential role in the pathogenesis of various extra-gastric disorders such as metabolic disorders. But, it is now questioned about whether H. pylori eradication reduces or induces the risk for metabolic disorders especially in patients with dyspepsia. Hence, the present study aimed to assess the effects of H. pylori eradication on criteria of metabolic syndrome. H. pylori infected patients with dyspepsia were included. The patients were treated with omeprazole (20mg, q12h), amoxicillin (1g, q12h), and clarithromycin (500mg, q12h) for two weeks, then H. pylori eradication was evaluated by C(14) Breathing test (UBT) 6 weeks after the end of the treatment. Demographic data, clinical manifestation and metabolic parameters were recorded before and three months after completing treatment regimen. The data was analyzed by SPSS version 16.0. Of 110 patients were initially enrolled, 91 patients completed the study. Overall eradication rate was 61.5%. Significant differences in the serum level of total cholesterol(180.7±34 vs. 172.1±28, p=0.001), LDL(107.0±25 vs. 100.8±20, ppylori eradication could relatively reduce the risk of metabolic syndrome criteria such as fasting blood sugar, hemoglobin A1c, lipid profile and waist circumference. Copyright © 2017. Published by Elsevier Ltd.

  18. Acupuncture for Functional Dyspepsia: What Strength Does It Have? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Science.gov (United States)

    Li, Jing; Li, Bo; Hu, Ya-Cai; Cai, Qiu-Han

    2016-01-01

    Background. Although the effectiveness of acupuncture therapy on functional dyspepsia (FD) has been systematically reviewed, the available reports are still contradictive and no robust evidence has been provided to date. Objective. To assess the current evidence of high quality on the effects of acupuncture for patients with FD. Methods. A comprehensive literature database search was conducted to identify randomized controlled trials (RCTs) comparing acupuncture therapies (including manual acupuncture and electroacupuncture) to sham acupuncture and medication use. A meta-analysis was performed following a strict methodology. Results. 16 RCTs involving 1436 participants were included. The majority of the trials were determined to be of low quality. Positive results were found for acupuncture in improving the Nepean Dyspepsia Index (NDI) and scores of the MOS 36-Item Short-Form Health Survey (SF-36), as well as in alleviating relevant symptoms (especially postprandial fullness and early satiation) of FD patients. Conclusion. Based on current available evidence, acupuncture therapy achieves statistically significant effect for FD in comparison with sham acupuncture and is superior to medication (prokinetic agents) in improving the symptoms and quality of life of FD patients. Nonetheless, despite stringent methodological analyses, the conclusion of our review still needs to be strengthened by additional RCTs of higher quality. PMID:28119758

  19. An Extract of Glycyrrhiza glabra (GutGard Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study

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    Kadur Ramamurthy Raveendra

    2012-01-01

    Full Text Available A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of GutGard, an extract of Glycyrrhiza glabra, in patients with functional dyspepsia. The primary outcome variables of the study were the change in the severity symptoms and the global assessment of efficacy. The quality of life was evaluated as a secondary outcome measure. The patients received either placebo or GutGard (75 mg twice daily for 30 days. Efficacy was evaluated in terms of change in the severity of symptoms (as measured by 7-point Likert scale, the global assessment of efficacy, and the assessment of quality of life using the short-form Nepean Dyspepsia Index. In comparison with placebo, GutGard showed a significant decrease (P≤.05 in total symptom scores on day 15 and day 30, respectively. Similarly, GutGard showed marked improvement in the global assessment of efficacy in comparison to the placebo. The GutGard group also showed a significant decrease (P≤.05 in the Nepean dyspepsia index on day 15 and 30, respectively, when compared to placebo. GutGard was generally found to be safe and well-tolerated by all patients. GutGard has shown significant efficacy in the management of functional dyspepsia.

  20. One-week acid suppression trial in uninvestigated dyspepsia patients with epigastric pain or burning to predict response to 8 weeks' treatment with esomeprazole

    DEFF Research Database (Denmark)

    van Zanten, S V; Flook, N; Talley, N J;

    2007-01-01

    BACKGROUND: While empiric acid-suppressive therapy for uninvestigated dyspepsia patients with symptoms of epigastric pain or burning is standard practice, it is unknown whether an early response to therapy predicts outcome. AIM: To evaluate whether a 1-w acid suppression trial is effective for pr...

  1. Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial

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    Bhupesh Dewan

    2011-01-01

    Full Text Available Background. Empirical therapy with antisecretory agents like PPIs and H2RAs has long been the traditional approach in the initial management of uninvestigated dyspepsia. Aim. The objective of the study was to examine relief of dyspepsia with lafutidine, a second-generation H2-RA, and rabeprazole and to compare their efficacy. Methods. This was a randomized, open, comparative trial in adult uninvestigated dyspeptic patients, who had at least moderate severity of symptoms, defined as a score of ≥4 on a 7-point global overall symptom (GOS scale, and were randomized to receive once daily either lafutidine 10 mg or rabeprazole 20 mg for 4 weeks. Results. A total of 236 patients were enrolled, out of which 194 patients were included in the analysis. At the end of week 4, a significant difference was observed for symptom relief (lafutidine 89.90% versus rabeprazole 65.26%, P<.01 and symptom resolution (lafutidine 70.71% versus rabeprazole 25.26%, P<.01. Both the drugs were well tolerated. Conclusion. Both lafutidine and rabeprazole provide symptom relief in patients with heartburn-dominant uninvestigated dyspepsia. The present study confirms the appropriateness of lafutidine as an empiric treatment and superior efficacy for primary care practice patients with dyspepsia.

  2. Assessment of Gastric Accommodation in Patients with Functional Dyspepsia by 99mTc-Pertechtenate Single Photon Emission Computed Tomography Imaging: Practical but not Widely Accepted

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    Taghi Amiriani

    2015-10-01

    Full Text Available Objective: Impaired gastric accommodation is one of the main symptoms in patients with functional dyspepsia. The aim of the present study was to assess gastric accommodation in patients with functional dyspepsia using single photon emission computed tomography (SPECT imaging. Methods: Twenty-four patients with functional dyspepsia and 50 healthy volunteers as control group were enrolled in this study. All participants were given 5 mCi 99mTc-pertechtenate intravenously, served with a low fat meal, and underwent SPECT scanning 20 minutes after the meal. Results: Based on the scintigraphic data, gastric volumes were found to be significantly increased after food ingestion in both patient and control groups. We also found that while there was no significant difference between patient and control groups in terms of fasting gastric volumes, postprandial gastric volume was significantly lower in patients as compared to healthy individuals (p<0.05. Conclusion: Measuring gastric volume by using SPECT can be a valuable method in the detection of functional dyspepsia and in differentiation of this entity from other organic disorders.

  3. Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: a Multi-Center, Randomized, Controlled Study

    Science.gov (United States)

    Talley, Nicholas J.; Locke, G. Richard; Saito, Yuri A.; Almazar, Ann E.; Bouras, Ernest P.; Howden, Colin W.; Lacy, Brian E.; DiBaise, John K.; Prather, Charlene M.; Abraham, Bincy P.; El-Serag, Hashem B.; Moayyedi, Paul; Herrick, Linda M.; Szarka, Lawrence A.; Camilleri, Michael; Hamilton, Frank A.; Schleck, Cathy D.; Tilkes, Katherine E.; Zinsmeister, Alan R.

    2015-01-01

    Background & Aims Anti-depressants are frequently prescribed to treat functional dyspepsia (FD), a common disorder characterized by upper abdominal symptoms, including discomfort or post-prandial fullness. However, there is little evidence for the efficacy of these drugs in patients with FD. We performed a randomized, double-blind, placebo-controlled trial to evaluate the effects of anti-depressant therapy effects on symptoms, gastric emptying (GE), and mealinduced satiety in patients with FD. Methods We performed a study at 8 North American sites of patients who met the Rome II criteria for FD and did not have depression or use anti-depressants. Subjects (n=292; 44±15 y old, 75% female, 70% with dysmotility-like FD, and 30% with ulcer-like FD) were randomly assigned to groups given placebo, 50 mg amitriptyline, or 10 mg escitalopram for 10 weeks. The primary endpoint was adequate relief of FD symptoms for ≥5 weeks of the last 10 weeks (out of 12). Secondary endpoints included GE time, maximum tolerated volume in a nutrient drink test, and FD-related quality of life. Results An adequate relief response was reported by 39 subjects given placebo (40%), 51 given amitriptyline (53%), and 37 given escitalopram (38%) (P=.05, following treatment, adjusted for baseline balancing factors including all subjects). Subjects with ulcer-like FD given amitriptyline were more than 3-fold more likely to report adequate relief than those given placebo (odds ratio=3.1; 95% confidence interval, 1.1–9.0). Neither amitriptyline nor escitalopram appeared to affect GE or meal-induced satiety after the 10 week period in any group. Subjects with delayed GE were less likely to report adequate relief than subjects with normal GE (odds ratio=0.4; 95% confidence interval, 0.2–0.8). Both anti-depressants improved overall quality-of-life. Conclusions Amitriptyline, but not escitalopram, appears to benefit some patients with FD— particularly those with ulcer-like (painful) FD. Patients

  4. Pathophysiological Abnormalities in Functional Dyspepsia Subgroups According to the Rome III Criteria.

    Science.gov (United States)

    Vanheel, H; Carbone, F; Valvekens, L; Simren, M; Tornblom, H; Vanuytsel, T; Van Oudenhove, L; Tack, J

    2017-01-01

    The Rome III criteria proposed to subdivide functional dyspepsia (FD) into a postprandial distress syndrome (PDS) group, characterized by the presence of postprandial fullness and/or early satiety, and an epigastric pain syndrome (EPS) group, characterized by the presence of epigastric pain and/or epigastric burning. It has been suggested that different pathophysiological mechanisms underlie the symptom presentations in these subgroups that might determine treatment choices. The aim of this study was to investigate the prevalence of gastric sensorimotor dysfunction in the PDS, EPS, and overlap groups and to evaluate potential differential associations with dyspeptic symptom scores. Consecutive FD patients fulfilling Rome III criteria were recruited and they scored frequency of dyspeptic symptoms (postprandial fullness, early satiety, nausea, bloating, epigastric pain, and epigastric burning) over the past 3 months (0-5; 1=once a month or less, 2=two or three times a month, 3=once a week, 4=several times a week, 5=every day). The cumulative symptom score was calculated by adding up the score of these dyspeptic symptoms. Based on these symptom scores, the patients were subdivided into subgroups according to the Rome III consensus: (i) PDS, characterized by postprandial fullness and/or early satiety at least several times a week, (ii) EPS, characterized by epigastric pain and/or epigastric burning at least once a week, and (iii) overlap, fulfilling the criteria for both PDS and EPS. Gastric sensitivity and gastric accommodation were measured using barostat testing, and solid gastric emptying was determined using the [(14)C]octanoate breath test. A total of 560 FD patients (165 men, age 41.8±0.7 years) were classified into PDS (n=131), EPS (n=50), and overlap (n=379) groups. The prevalence of gastric hypersensitivity, impaired gastric accommodation, and delayed gastric emptying were 37%, 37%, and 23%, respectively, without any differential distribution in Rome III

  5. Psychopathological features of irritable bowel syndrome patients with and without functional dyspepsia: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Pallotta Nadia

    2011-08-01

    Full Text Available Abstract Background Irritable bowel syndrome (IBS and functional dyspepsia (FD show considerable overlap and are both associated with psychiatric comorbidity. The present study aimed to investigate whether IBS patients with FD show higher levels of psychopathology than those without FD. As a preliminary analysis, it also evaluated the psychopathological differences, if any, between IBS patients featuring the two Rome III-defined FD subtypes, i.e. postprandial distress syndrome (PDS and epigastric pain syndrome (EPS. Methods Consecutive outpatients (n = 82, F = 67, mean age 41.6 ± 12.7 years referred to our third level gastroenterological centre, matching the Rome III criteria for IBS and, if present, for concurrent FD, were recruited. They were asked to complete a 90-item self-rating questionnaire, the Symptom Checklist 90 Revised (SCL-90-R, in order to assess the psychological status. Comparisons between groups were carried out using the non-parametric Mann-Whitney U test. Results Patients with IBS only were 56 (68.3%, F = 43, mean age 41.6 ± 13.3 years and patients with both IBS and FD were 26 (31.7%, F = 24, mean age 41.8 ± 11.5 years, 17 of whom had PDS and 9 EPS. Patients with both IBS and FD scored significantly higher on the SCL-90-R GSI and on eight out of the nine subscales than patients with IBS only (P ranging from 0.000 to 0.03. No difference was found between IBS patients with PDS and IBS patients with EPS (P ranging from 0.07 to 0.97, but this result has to be considered provisional, given the small sample size of the two subgroups. Conclusions IBS-FD overlap is associated with an increased severity of psychopathological features. This finding suggests that a substantial subset of patients of a third level gastroenterological centre with both IBS and FD may benefit from psychological assessment and treatment.

  6. Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study

    Institute of Scientific and Technical Information of China (English)

    Katherine Zybach; Craig A Friesen; Jennifer V Schurman

    2016-01-01

    AIM: To study the effectiveness of melatonin vs placebo in children with functional dyspepsia(FD).METHODS: The study was conducted as a double blind, randomized, placebo controlled crossover trial. Subjects were aged 8-17 years and diagnosed with FD based on Rome Ⅲ criteria. All subjects had failed to respond to 4 wk of acid suppression. Subjects receive a continuous two weeks of placebo and a continuous two weeks of melatonin in an order blinded to the participant and the study team. A Global Clinical Score was obtained to assess changes in abdominal pain. Pain was self-reported to be worse(grade 1), no change(grade 2), moderate improvement(grade 3), good(grade 4; minimal pain and not interfering with daily activities), or excellent(grade 5; no pain), respectively. A positive clinical response was defined as a grade 3 or greater response. Subjects wore an actigraph to assess sleep during a one week baseline period and during each treatment period. Subjects’ sleep latency and total sleep time were recorded throughout the duration of the study. RESULTS: Fourteen subjects were enrolled and 12 completed the study. One withdrew prior to starting both melatonin and placebo and the other before starting melatonin. A positive clinical response(grade 3-5) was achieved in 42% of subjects on melatonin vs 50% of subjects on placebo(NS). Effect size was calculated and revealed a Cohen’s D of 0.343 which demonstrates a medium effect favoring placebo. A grade 4 or grade 5 response was seen in 4 patients on melatonin and 5 patients on placebo. Baseline sleep parameters were in the healthy range with the longest sleep latency being just over 20 min(mean 7.46 ± 8.53 min) and the shortest sleep duration just over 7 h(mean 10.09 ± 2.72 h). The mean latency did not differ between periods of treatment with melatonin as compared to placebo(4.48 ± 6.45 min vs 3.58 ± 4.24 min; NS). The mean sleep duration did not differ between periods of treatment with melatonin as compared to

  7. The Intragastric Pressure Measurement: A Novel Method to Assess Gastric Accommodation in Functional Dyspepsia Children.

    Science.gov (United States)

    Carbone, Florencia; Tack, Jan; Hoffman, Ilse

    2017-06-01

    Impaired gastric accommodation (GA) is proposed as a main pathophysiological mechanism for functional dyspepsia (FD). At present, the gastric barostat is the criterion standard to measure GA. Hence, this procedure is invasive and it may alter gastric physiology. Recently, we proposed the measurement of intragastric pressure (IGP) by means of high-resolution manometry during nutrient intake as a potential alternative for assessing GA in adults. Our aim was first to study the feasibility of the IGP measurement with nutrient tolerance in children with FD and second to compare these results with young healthy adults. A high-resolution manometry probe and a feeding tube were positioned in the proximal stomach. The IGP was measured before and during intragastric infusion of a nutrient drink (ND, 300 kcal, 60 mL/min). Subjects were asked to score their satiation and epigastric symptoms. The test ended when the subjects scored maximal satiation. A total of 15 healthy volunteers (HVs, 21.7 ± 4.7 years, 21.1 ± 0.3 kg/m) and 17 patients with FD (14.4 ± 0.7 years, 19.6 ± 0.7 kg/m) participated. Patients with FD experienced mainly from postprandial fullness (86%), epigastric pain (71%), and bloating (62%). In both groups, intragastric infusion of ND induced a drop in IGP (area above the IGP curve FD: -15.5 ± 3.5 mmHg vs HVs: -18.0 ± 8.7 mmHg; P = 0.57). Patients showed impaired nutrient tolerance compared with HVs (587.6 ± 80.2 vs 936 ± 66.2 kcal; P = 0.003). All patients and HVs tolerated the catheters and could finalize the study. The measurement of IGP during intragastric ND infusion was well tolerated in children. Nutrient tolerance was reduced in children with FD compared with HVs. In the future, this may be a useful tool to assess GA accommodation and nutrient tolerance in children.

  8. Peptide YY3-36 and glucagon-like peptide-1 in functional dyspepsia. Secretion and role in symptom generation

    DEFF Research Database (Denmark)

    Witte, Anne-Barbara; Hilsted, Linda; Holst, Jens Juul

    2016-01-01

    -36, GLP-1, dyspeptic symptoms, and satiety measurements. MATERIALS AND METHODS: Thirty-six patients with functional dyspepsia and 18 healthy controls consumed a liquid meal at two occasions. Firstly, a fixed amount of 250 mL (300 kcal) was consumed and gastric emptying was assessed using the paracetamol...... method. Secondly, participants drank 75 mL (90 kcal) per five min until maximal satiety. PYY3-36, GLP-1, glucose, and insulin concentrations were assessed. Satiety measures and dyspeptic symptoms were registered using visual analogue scales. RESULTS: Gastric emptying, glucose, PYY3-36, and GLP-1...... concentrations were similar in patients and controls. Patients with epigastric pain syndrome had higher postprandial insulin levels. Patients reported more satiety, nausea, and pain. Area under the curve (AUC) for GLP-1 correlated positively to nausea in patients and negatively to nausea in controls during...

  9. Symptom-based tendencies of Helicobacter pylori eradication in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    LingLan; ]ingYu; Yu—LongChen; Ya—LiZhong; HaoZhang; Chang HeJia; YuanYuan; Bo—WeiLiu

    2011-01-01

    AIM: To investigate whether there were symptom-based tendencies in the Helicobacter pylori (H. pylori) eradication in functional dyspepsia (FD) patients. METHODS: A randomized, single-blind, placebo-controlled study of H. pylori eradication for FD was conduct- ed. A total of 195 FD patients with H. pylori infection were divided into two groups: 98 patients in the treatment group were treated with rabeprazole 10 mg twice daily for 2 wk, amoxicillin 1.0 g and clarithromycin 0.5 g twice daily for 1 wk; 97 patients in the placebo group were given placebos as control. Symptoms of FD, such as postprandial fullness, early satiety, nausea, belching,epigastric pain and epigastric burning, were assessed 3 mo after H. pylori eradication. RESULTS: By per-protocol analysis in patients with successful H. pylori eradication, higher effective rates of 77.2% and 82% were achieved in the patients with epigastric pain and epigastric burning than those in the placebo group (P 〈 0.05). The effective rates for postprandial fullness, early satiety, nausea and belching were 46%, 36%, 52.5% and 33.3%, respectively, and there was no significant difference from the placebo group (39.3%, 27.1%, 39.1% and 31.4%) (P 〉 0.05). In 84 patients who received H. pylori eradication therapy, the effective rates for epigastric pain (73.8%) and epigastric burning (80.7%) were higher than those in the placebo group (P 〈 0.05). The effective rates for postprandial fullness, early satiety, nausea and belch- ing were 41.4%, 33.3%, 50% and 31.4%, respective- ly, and did not differ from those in the placebo group (P 〉 0.05). By intention-to-treat analysis, patients with epigastric pain and epigastric burning in the treatment group achieved higher effective rates of 60.8% and 65.7% than the placebo group (33.3% and 31.8%) (P 〈 0.05). The effective rates for postprandial fullness, early satiety, nausea and belching were 34.8%, 27.9%, 41.1% and 26

  10. DIAGNOSTIC ACCURACY OF UREA BREATH TEST FOR HELICOBACTER PYLORI INFECTION IN CHILDREN WITH DYSPEPSIA IN COMPARISON TO HISTOPATHOLOGY

    Directory of Open Access Journals (Sweden)

    Naser HONAR

    Full Text Available ABSTRACT Background - Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective - In this study, we evaluate the accuracy of urea breath test (UBT with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods - This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13 as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results - The mean age of the participants was 10.1±2.6 (range 7-17 years. From our total 60 patients, 28 (46.7% had positive UBT results and 32 (53.3% had negative UBT results. Pathologic report of 16 (57.1% out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9% ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion - Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended.

  11. Prevalence of uninvestigated dyspepsia and gastroesophageal reflux disease in Korea: a population-based study using the Rome III criteria.

    Science.gov (United States)

    Min, Byung-Hoon; Huh, Kyu Chan; Jung, Hye-Kyung; Yoon, Young Hoon; Choi, Kee Don; Song, Kyung Ho; Keum, Bora; Kim, Jung Won

    2014-11-01

    There have been few population-based studies on the prevalences of gastroesophageal reflux disease (GERD) and dyspepsia using Rome III criteria in Asian countries. A population-based, cross-sectional study was conducted by telephone interviews of 5,000 Koreans between the ages of 20-69 years. Gastrointestinal symptoms were assessed by a translated Korean version of Rome III criteria. Uninvestigated dyspepsia (UID) was defined by symptom criteria of Rome III. GERD was defined by troublesome heartburn and/or acid regurgitation occurring at least once a week. The EQ5D assessment tool was used for the evaluation of quality of life. The prevalences of UID, postprandial distress syndrome (PDS), and epigastric pain syndrome (EPS) were 7.7, 5.6, and 4.2 %, respectively. Overlap between PDS and EPS was found in 27.1 % (104/384) of subjects with UID. There were no significant differences in demographic variables between patients with PDS and EPS. The prevalence of GERD was 7.1 %. Overlap between GERD and UID was found in 50.0 % of GERD patients. The EQ5D index of patients without either UID or GERD was 0.92 ± 0.07, and those of patients with only UID, with only GERD, and with both UID and GERD were 0.88 ± 0.09, 0.88 ± 0.11, and 0.84 ± 0.15, respectively. GERD and UID based on Rome III criteria were prevalent and significantly affected the quality of life in Korea. In Korean patients with UID, there was considerable overlap and there were no significant differences in demographic variables between PDS and EPS.

  12. The personality patterns in patients with duodenal ulcer and ulcer-like dyspepsia and their relationship to the course of the diseases. Hvidovre Ulcer Project Group

    DEFF Research Database (Denmark)

    Jess, P; Eldrup, J

    1994-01-01

    OBJECTIVES. To compare personality characteristics in duodenal ulcer patients and patients with ulcer-like dyspepsia from the primary health sector with duodenal ulcer patients from a hospital and to evaluate the relationship of the personality characteristics to the course of the diseases. DESIGN....... A prospective study using the Minnesota Multiphasic Personality Inventory (MMPI) with retesting of a subgroup of patients after a median observation period of 14 months. SETTING. Departments of Medical and Surgical Gastroenterology, Hvidovre University Hospital, and the primary health sector in Roskilde County......, Denmark. SUBJECTS. Sixty hospital patients with duodenal ulceration and 17 patients with duodenal ulceration plus 25 patients with ulcer-like dyspepsia from the primary health sector. MAIN OUTCOME MEASURES. MMPI scores. RESULTS. The hospital patients differed from the two other groups of patients...

  13. Comparative evaluation of conventional methods and elisa based IgG antibodies detection for diagnosis of helicobacter pylori infection in cases of dyspepsia

    Directory of Open Access Journals (Sweden)

    Arora U

    2003-01-01

    Full Text Available Seventy five gastric biopsy specimens and 75 serum samples of same patients complaining of dyspepsia were collected. Biopsy specimens were processed for rapid urease test, gram staining and culture. Serum samples were used for detecting IgG antibodies against 128kDa external protein (Cog A of H.pylori using a commercially available ELISA kit. Rapid urease test was positive in 54 (72%, culture in 21 (28% and gram staining in 15 (20%. Significant IgG levels were detected in 57 (76% cases. It was therefore concluded that for diagnosis of H.pylori infection in cases of dyspepsia, determination of IgG levels can act as an important screening procedure.

  14. [Overlap of irritable bowel syndrome and functional dyspepsia based on Rome III criteria in medical students from a private university in Lima, Peru].

    Science.gov (United States)

    Vargas-Matos, Iván; Ng-Sueng, Luis Fernando; Flores-Arriaga, Joel; Beltrán-Flores, Santiago; Lema-Correa, Mauricio; Piscoya, Alejandro; Mayta-Tristán, Percy

    2015-01-01

    To determine the prevalence of irritable bowel syndrome and functional dyspepsia in medical students from a private university in Lima, Peru. Furthermore, to determine the associated factors with these diseases. Observational descriptive and retrospective cross sectional study. Medical students from a private university in Lima were surveyed using a Rome III questionnaire for functional disorders and the STEPwise auto survey for defining the variables of alcohol and tobacco. For data analysis the Stata 11.0 program was used. Of the 608 students, 543 answered the questionnaire. The prevalence of Irritable Bowel Syndrome was 12.4%, 16.9% of dyspepsia, and of both diseases simultaneously, a prevalence of 7.1% was found. Alcohol consumption in the total population was 89.4% and 29.0% of tobacco. Association between both disorders was found (OR 10.47, 95% CI 5.08 to 21.55; p < 0.001), dyspepsia was associated with sex (OR: 0.16, 95% CI 0.07 to 0.36 p < 0.001), with alcohol consumption (OR: 5.22, 95% CI 23.99 1,13- p = 0.034) and with irritable bowel syndrome (OR: 9.88, 95% CI 4.78 to 20.46 p <0.001). Both conditions together were associated with sex (OR: 0.20, 95% CI from 0.06 to 0.60 p = 0.004) and daily consumption of tobacco (OR: 3.23, 95% CI 1.17 to 8.89 p = 0.023). A prevalence of 12.4% of Irritable Bowel Syndrome and 16.9% of dyspepsia was determined. An overlap of 7.1% of these diseases was reported.

  15. 功能性消化不良胃排空及食物分布与症状的关系%Relationship between gastric emptying and intragastric distribution and dyspepsia symptoms in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    刘秋月; 严祥; 马苏美

    2013-01-01

    目的:探讨功能性消化不良(FD)患者不同胃区胃排空及胃内食物分布与症状之间的关系。方法采用实时超声检测73例FD患者和27例正常对照组胃排空功能,并调查73例FD患者的症状。结果 FD患者各胃区半排空时间均较正常对照组延长(P<0.05),胃排空延迟率明显增加(P<0.01);远端胃半排空时间与早饱、体重指数呈正相关(P<0.05);全胃半排空时间与年龄呈负相关(P<0.05);分别对各胃区排空情况与症状进行Logistic回归分析,仅早饱与远端胃排空延迟相关(P<0.05);20 min、40 min近端胃面积,40 min全胃面积与上腹部烧灼感呈负相关(P<0.05);20 min、40 min远端胃面积与早饱呈负相关(P<0.05)。结论 FD患者存在胃排空异常,远端胃排空情况与早饱存在相关性。%Objective To study relationship between gastric emptying on proximal stomach, distal stomach, total stomach and intragastric distribution and dyspepsia symptoms in patients with functional dyspepsia (FD). Methods A real-time ultrasonography was performed in 73 cases of FD patients and 27 healthy controls (HC). Dyspepsia symptoms were investigated by using a questionnaire. Results As compared with that in HC group, the half time of gastric emptying on proximal stomach (pT1/2), half time of gastric emptying on distal stomach (dT1/2) and gastric emptying half-time on total stomach (GT1/2) was prolonged significantly in FD (P<0.05).The delay rate of proximal stomach, distal stomach and total gastric was significantly increased (P<0.01). In FD patients, dT1/2 and early satiety, body mass index were related (P<0.05);GT1/2 was negative correlated with age (P<0.05). Taking gastric emptying and symptoms for logistic regression analysis, the only relationship was between delayed distal gastric emptying and early satiety (P<0.05). There were negative correlations between proximal gastric area at 20, 40 min

  16. Prevalence of functional dyspepsia and its subgroups in patients with eating disorders

    Institute of Scientific and Technical Information of China (English)

    Antonella Santonicola; Monica Siniscalchi; Pietro Capone; Serena Gallotta; Carolina Ciacci; Paola Iovino

    2012-01-01

    AIM:To study the prevalence of functional dyspepsia (FD) (Rome Ⅲ criteria) across eating disorders (ED),obese patients,constitutional thinner and healthy volunteers.METHODS:Twenty patients affected by anorexia nervosa,6 affected by bulimia nervosa,10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders,4th edition,nine constitutional thinner subjects and,thirtytwo obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.Twentytwo healthy volunteers matched for age and gender were enrolled as healthy controls.All participants underwent a careful clinical examination.Demographic and anthropometric characteristics were obtained from a structured questionnaires.The presence of FD and,its subgroups,epigastric pain syndrome and postprandial distress syndrome (PDS) were diagnosed according to Rome Ⅲ criteria.The intensity-frequency score of broader dyspeptic symptoms such as early satiety,epigastric fullness,epigastric pain,epigastric burning,epigastric pressure,belching,nausea and vomiting were studied by a standardized questionnaire (0-6).Analysis of variance and post-hoc Sheffè tests were used for comparisons.RESULTS:90% of patients affected by anorexia nervosa,83.3% of patients affected by bulimia nervosa,90% of patients affected by ED not otherwise specified,55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria (x2,P < 0.001).Only one bulimic patient met the epigastric pain syndrome diagnosis.Postprandial fullness intensity-frequency score was significantly higher in anorexia nervosa,bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group (4.15 ± 2.08 vs 1.44 ± 2.35,P =0.003; 5.00 ±2.45 vs 1.44 ± 2.35,P =0.003; 4.10 ± 2.23 vs 1.44 ±2.35,P =0.002,respectively),the obese group (4.15 ± 2.08 vs 0.00 ± 0.00,P < 0.001; 5.00 ± 2

  17. STUDY OF UPPER GASTROINTESTINAL ENDOSCOPY FINDINGS AND PRESENCE OF HELICOBACTER PYLORI INFECTION AMONG ADULT PATIENTS OF UPPER ABDOMINAL PAIN AND DYSPEPSIA

    Directory of Open Access Journals (Sweden)

    Manju Singh

    2017-03-01

    Full Text Available BACKGROUND Dyspepsia is a common presenting complaint of various upper gastrointestinal disorders. The symptoms of causes of dyspepsia often overlap and this makes aetiological diagnosis difficult. Endoscopy is the ideal procedure for identifying organic diseases of the foregut and rapid urease test with endoscopy is a gold standard method for diagnosing the h.pylori infection. Helicobacter pylori infection is associated with various upper gastrointestinal pathologies. MATERIALS AND METHODS This hospital-based case-controlled study was carried out in a tertiary hospital, Dr. Bhim Rao Ambedkar Hospital, which is attached to Pt. J.N.M. Medical College, Raipur, and which provides open access service to endoscopy. Eighty two consecutive adult outpatients and admitted patients under Department of Surgery and Medicine with upper abdominal pain and dyspepsia were screened for eligibility and underwent upper gastrointestinal endoscopy using forward-viewing endoscopes from March 2015 to September 2016. Patients with dyspepsia who are over 18 years of age should undergoendoscopy (EGD for initial work up and divided in case having endoscopic findings and control having normal findings, then apply rapid urease test to all of these patients. RESULTS The most commonly identified endoscopic findings were gastritis (36%, Peptic Ulcer Disease (PUD (13.3%, oesophagitis (11%, duodenitis (7.3%. Gastric cancer was identified in 4.9% of patients and all of them were aged 18 years and above (p>0.05. H. pylori infection was detected in 51% (n=42 of patients. Gastritis andoesophagitis were statistically significantly associated with H. pylori (p0.05. Gastritis, GERD and PUD are the leading causes of dyspepsia. H. pylori infection is present in significant proportion of dyspeptic patients. CONCLUSION In present study, we are concluded that all upper abdominal pain is not due to acid peptic disease, but most of upper abdominal pain is due to acid peptic disease with H

  18. The effects of concomitant GERD, dyspepsia, and rhinosinusitis on asthma symptoms and FeNO in asthmatic patients taking controller medications

    Directory of Open Access Journals (Sweden)

    Ishizuka T

    2014-09-01

    Full Text Available Tamotsu Ishizuka,1,2 Takeshi Hisada,2 Yosuke Kamide,2 Haruka Aoki,2 Kaori Seki,2 Chisato Honjo,1 Hiroyuki Sakai,1 Maiko Kadowaki,1 Yukihiro Umeda,1 Miwa Morikawa,1 Masaki Anzai,1 Shingo Ameshima,1 Takeshi Ishizaki,1 Kunio Dobashi,2 Masanobu Yamada,2 Motoyasu Kusano3 1Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, 2Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Japan Background: Losing the sense of smell, which suggests eosinophilic rhinosinusitis, is a subjective symptom, sometimes reported in asthmatic patients taking controller medication. Upper abdominal symptoms, suggesting gastroesophageal reflux disease (GERD or functional dyspepsia, occur also in these patients. However, the relationship between these symptoms, concomitant with asthma, and the intensity of eosinophilic airway inflammation remains obscure. Objective: To assess the symptoms of asthma and rhinosinusitis, and to examine the relationship between the symptoms and bronchial inflammation, a new questionnaire, the G scale, was developed. To investigate the effects of GERD, dyspepsia, and rhinosinusitis on asthma symptoms and bronchial inflammation, the symptoms of asthma and rhinosinusitis obtained by the G scale, upper abdominal symptoms obtained by the modified F scale, a questionnaire for GERD and dyspepsia, and fractional exhaled nitric oxide (FeNO were analyzed. Methods: A prospective, observational study was performed in four hospitals in Gunma prefecture, and a retrospective analysis was done using data obtained from five hospitals in Gunma prefecture and Fukui prefecture, Japan. A total of 252 patients diagnosed as having asthma participated in the prospective study. Results: The frequency of daytime phlegm or losing the sense of smell had a positive correlation with FeNO levels in asthmatic

  19. Efecto del tratamiento erradicador para Helicobacter pylori en pacientes con dispepsia funcional Effect to Helicobacter pylori eradication on patients with functional dyspepsia

    Directory of Open Access Journals (Sweden)

    T. de Artaza Varasa

    2008-09-01

    Full Text Available Objetivo: este estudio ha tenido un doble objetivo: por un lado, evaluar el efecto del tratamiento erradicador para Helicobacter pylori en la respuesta sintomática de pacientes diagnosticados de dispepsia funcional y, por otro, determinar si los hallazgos histológicos podían servir como predictor de la efectividad de la terapia. En particular, se trató de averiguar si la presencia de gastritis antral (la que se asocia a la enfermedad ulcerosa péptica podría predecir una mayor respuesta sintomática al tratamiento erradicador en los pacientes con dispepsia funcional e infección por Helicobacter pylori. Pacientes y métodos: estudio prospectivo, monocéntrico y aleatorizado, que incluyó a 48 pacientes con dispepsia funcional e infección por Helicobacter pylori (27 mujeres y 21 hombres, con edad media de 37 ± 13,5 años. Veintisiete pacientes recibieron el tratamiento erradicador (rabeprazol, claritromicina y amoxicilina durante 10 días, seguido de 20 mg/día de rabeprazol 3 meses y 21 el tratamiento control (20 mg/día de rabeprazol 3 meses. Los pacientes fueron seguidos durante un año. Todos rellenaron el Cuestionario de calidad de vida asociada a dispepsia, que evalúa cuatro apartados: intensidad de los síntomas habituales, intensidad del dolor de estómago, incapacidad debida al dolor y satisfacción con la salud. Resultados: existió una mejoría significativa (p Objective: this study evaluated Helicobacter pylori eradication therapy in terms of symptomatic response in patients with functional dyspepsia. On the other hand, we analyzed the importance of histologic findings as a predictor of treatment response. In particular, we studied whether antral gastritis (which is associated with peptic ulcer may predict a greater symptomatic response to Helicobacter pylori eradication in functional dyspepsia. Patients and methods: this prospective, randomized, single-center trial included 48 patients with functional dyspepsia and

  20. Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial

    Directory of Open Access Journals (Sweden)

    Atsushi Takagi

    2016-01-01

    Full Text Available Some Lactobacillus spp. suppress Helicobacter pylori in the stomach and have potential therapeutic applications for the treatment of gastrointestinal conditions. In this study, the effects of Lactobacillus strains on functional dyspepsia associated with H. pylori infection were examined. Volunteers were screened using the 13C-urea breath test (UBT and H. pylori stool test, and 131 participants who met the selection criteria (mean age: 48.9 years were randomly given L. gasseri OLL2716-containing yogurt or placebo yogurt once daily for 12 weeks. Gastrointestinal symptoms (epigastric pain, bloating, postprandial fullness, nausea, and heartburn and the levels of serum pepsinogen (PG, 13C-UBT, and H. pylori stool antigen were assessed. No significant differences were observed between the groups in UBT results, H. pylori stool antigens, or the serum PGI/II ratio. In the L. gasseri group, postprandial fullness was significantly lower at the end of the trial compared to the initial level (p10 for bloating compared to the placebo group (p<0.05. Dietary supplementation with L. gasseri OLL2716-containing yogurt may effectively suppress dyspeptic symptoms in H. pylori-infected patients. This study was registered at the University Hospital Medical Network Clinical Trial Registry (UMIN000016746.

  1. Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study

    Directory of Open Access Journals (Sweden)

    Jiliang Fang

    2015-01-01

    Full Text Available Objective. To explore acupuncture effects on brain functional connectivity in patients with functional dyspepsia (FD. Methods. Eight patients in an acupuncture treatment group and ten healthy adults in the control group participated in the study. Acupuncture effectiveness was evaluated based on changes of the gastrointestinal symptoms, gastric motility measurements, and gastrin levels and comparisons with the control group when appropriate. To investigate functional connectivity changes related to FD and potential modulation after acupuncture, a set of regions of interest (ROIs were selected according to previous fMRI reports of acupuncture. Results. Patients showed significant improvements of FD signs and symptoms after acupuncture treatments. For all of the ROIs, we identified subportions of the networks showing reduced connectivity in patients with FD. Connectivity between the ROIs and corresponding disease targets showed significant improvement after acupuncture treatment (P<0.05 in all ROIs except for right medial temporal lobe-hippocampus and right inferior parietal lobule. Conclusion. Functional connectivity of the brain is changed in patients with FD but approximates that in healthy control after acupuncture treatment. The relief of gastrointestinal signs and symptoms by acupuncture is likely due to the normalization of brain-gut axis associated with FD.

  2. Validity and Reliability of the Japanese Version of the Rome III Diagnostic Questionnaire for Irritable Bowel Syndrome and Functional Dyspepsia.

    Science.gov (United States)

    Kanazawa, Motoyori; Nakajima, Shigemi; Oshima, Tadayuki; Whitehead, William E; Sperber, Ami D; Palsson, Olafur S; Drossman, Douglas A; Miwa, Hiroto; Fukudo, Shin

    2015-10-01

    Reliable diagnostic instruments for measuring the presence of functional gastrointestinal disorders based on the Rome III criteria have been lacking in Japan. The aims of the present study were to translate and validate the Rome III diagnostic questionnaire which was widely used in Western countries. The original version of Rome III diagnostic questionnaire was translated from English into Japanese through 3 independent forward translations, resolution, back translation and reconciliation of the differences. Forty-nine patients with irritable bowel syndrome (IBS), 32 patients with functional dyspepsia (FD) and 56 subjects without any current GI symptoms as controls were recruited from three hospitals located in different regions of Japan and completed the IBS and FD diagnostic modules twice within 14 days. Kappa statistic was used to assess test-retest reliability. The sensitivity and specificity of each diagnostic module for distinguishing IBS or FD patients from controls was tested. Median kappa statistics were 0.63 for the translated IBS diagnostic module and 0.68 for the FD module. The sensitivity, specificity, and positive predict value of the IBS module against physician diagnosis was 61.2%, 100%, and 100% and those of the FD module was 53.2%, 98.2%, and 94.4%, respectively. Meanwhile, IBS patients were significantly more likely to report blood in stools compared to controls (18.4% vs 1.8%, P Rome III diagnostic questionnaire are valid and reliable. Further studies are warranted to elucidate the diagnostic utility of the red flag questionnaire.

  3. Epidemiology and risk factors of uninvestigated dyspepsia, irritable bowel syndrome, and gastroesophageal reflux disease among students of Damascus University, Syria.

    Science.gov (United States)

    Al Saadi, Tareq; Idris, Amr; Turk, Tarek; Alkhatib, Mahmoud

    2016-12-01

    Uninvestigated dyspepsia (UD), irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD) are common disorders universally. Many studies have assessed their epidemiological characteristics around the world. However, such information is not known for Syria. We aim to estimate the epidemiologic characteristics and possible risk factors for UD, IBS, and GERD among students at Damascus University, Damascus, Syria. A cross-sectional study was conducted in July-September 2015 at a campus of Damascus University. A total of 320 students were randomly asked to complete the survey. We used ROME III criteria to define UD and IBS, and Montreal definition for GERD. In total, 302 valid participants were included in the analysis. Prevalence for UD, IBS, and GERD was 25%, 17%, and 16%, respectively. Symptom overlap was present in 46 students (15%), with UD+IBS in 28 (9.3%), UD+GERD in 26 (8.6%), and IBS+GERD in 14 (4.6%) students. Eleven (3.6%) students had symptoms of UD+IBS+GERD. Each of these overlaps occurred more frequently than expected by chance. Significant risk factors included cigarettes smoking, waterpipe consumption, and body mass index coffee/d for IBS; and two cups of tea and one to five cigarettes/d for GERD. Risk factors for these disorders remain poorly characterized and need further investigations. Copyright © 2016 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

  4. Effect of triple viable bifidobacterium combined with mosapride on hemorheology and serum gastrointestinal hormone levels in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Shun-Bin Ding; Ming-Chun Cai; Wen-Li Zhang; Tian-Hua Jiang

    2016-01-01

    Objective:To observe the effect of triple viable bifidobacterium combined with mosapride on hemorheology and serum gastrointestinal hormone levels in patients with functional dyspepsia (FD).Methods: A total of 127 patients with FD were randomly divided into the observation group (67cases) and the control group (62 cases). The control group was given mosapride, the observation group was given triple viable bifidobacterium on the base of the control group. For 2 months, to observe the efficacy and changes of hemorheology [the whole blood viscosity (high and low shear), plasma viscosity] and serum gastrointestinal hormone levels (MTL, NPY, VIP). Results: After treatment, the observation group of the whole blood viscosity (high and low shear), plasma viscosity were decreased significantly (P0.05). There was significantly difference between the two groups (P<0.05); After treatment, serum MTL, NPY were increased and VIP was increased in both groups (P<0.05), and all indexes of the observation group were improved more significant than those of the control group (P<0.05).Conclusions:Efficacy of triple viable bifidobacterium combined with mosapride is more better than single mosapride in the treatment of FD. It may be related to its effects on hemorheology and gastrointestinal hormone.

  5. Maximum tolerated volume in drinking tests with water and a nutritional beverage for the diagnosis of functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Aldo Monta(n)o-Loza; Max Schmulson; Sergio Zepeda-Gómez; Jose Maria Remes-Troche; Miguel Angel Valdovinos-Diaz

    2005-01-01

    AIM: Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD patients and controls in a Mexican population. METHODS: Twenty FD-Rome Ⅱ patients were matched by age and gender with 20 healthy controls. All underwent both drinking tests at a 15 mL/min rate, randomly, 7 d apart. Every 5 min within each test, four symptoms were evaluated (satiety, bloating, nausea and pain) by Likert scales. Maximum tolerated volume (MTV) was defined as the ingested volume when a score of 5 was reached for any symptom or when the test had to be stopped because the patients could not tolerate more volume. Sensitivity and specificity were analyzed. RESULTS: FD patients had higher symptom scores for both tests compared to controls (water: t= 4.1, P= 0.001 <0.01; Nutren(R): t= 5.2, P= 0.001<0.01). The MTV forwater and Nutren(R) were significantly lower in FD (water: 1014±288 vs 1749±275 mL; t = 7.9, P = 0.001<0.01;Nutren(R): 652±168 vs 1278±286 mL; t= 6.7, P = 0.001<0.01). With the volume tolerated by the controls, the percentile 10 was determined as the lower limit fortolerance. Sensitivity and specificity were 0.90, 0.95 for water and 0.95, 0.95 for Nutren(R) tests.CONCLUSION: A drinking test with water or a nutritional beverage can discriminate between FD patients and healthy subjects in Mexico, with high sensitivity and specificity. These tests could be used as objective, noninvasive, and safe diagnostic approaches for FD patients.

  6. Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: A double-blind randomized clinical trial

    Directory of Open Access Journals (Sweden)

    S Ashraffodin Ghoshegir

    2014-01-01

    Full Text Available Background: We aimed to assess the effects of anise on quality of life (QOL of patients with functional dyspepsia (FD in a double-blind randomized clinical trial. Materials and Methods: Of 180 patients attending the gastroenterology clinic, 107 ones with the diagnosis of postprandial distress syndrome according to Rome III criteria were enrolled. They were randomized into two groups, anise and placebo. Anise group involved 47 patients and received anise powders, 3 g after each meal (3 times/day for 4 weeks. Control group had 60 patients who received placebo powders (cornstarch, 3 g after each meal (3 times/day for 4 weeks. The QOL was assessed by short-form (SF-36 questionnaire. Mean scores of eight health domains of the two groups were compared at baseline and at the end of study. Results: The age, sex, body mass index, smoking history, tea and coffee drinking patterns of the two groups were not significantly different. All domains of SF-36 were similar between the two groups at baseline but were significantly different at week 12. At baseline, mean score of physical component summary was 159 in placebo group and 167 in anise group (P = 0.1. At week 12, the score was 141 in placebo group and 251 in anise group (P = 0.0001. Mean baseline score of mental component summary was 172 and 165 in placebo and anise groups, respectively (P = 0.1. At week 12, the score was 135 in placebo group and 233 in anise group (P = 0.0001. Conclusion: The current study revealed the effectiveness of anise in improvement of QOL in patients with FD.

  7. Duodenal eosinophilia and early satiety in functional dyspepsia: confirmation of a positive association in an Australian cohort.

    Science.gov (United States)

    Walker, Marjorie M; Aggarwal, Kavita R; Shim, Lisa Se; Bassan, Milan; Kalantar, Jamshid S; Weltman, Martin D; Jones, Michael; Powell, Nicholas; Talley, Nicholas J

    2014-03-01

    Functional dyspepsia (FD), defined by unexplained pain or discomfort centered in the upper abdomen, is common. Diagnosis and treatment of FD based on the symptom-based Rome criteria remains challenging. Recently, eosinophilia in the duodenum has been implicated in the pathophysiology of FD in adults, specifically increased eosinophils in early satiety and postprandial distress, but the association remains controversial. The aim of this study was to characterize upper gastrointestinal (GI) tract pathology, specifically duodenal eosinophilia, in an Australian cohort of patients with FD. Patients prospectively referred for an upper GI endoscopy (n = 55; mean age, 49.6 years; 61.8% female) were stratified to FD cases (n = 33) and controls (n = 22) using Rome II criteria. All subjects completed a validated bowel symptom questionnaire. The eosinophil count per square millimeter in the duodenal bulb (D1) and second part (D2) was assessed and Helicobacter pylori status determined by gastric histology. Associations with clinical symptoms were assessed. Cases and controls were demographically similar. Duodenal eosinophilia was significantly increased in subjects experiencing early satiety (P = 0.01) and postprandial fullness (P = 0.001). This association was seen in D2 but not D1. Abdominal pain was associated with eosinophilia in both D1 (P = 0.02) and D2 (P = 0.005). Smoking was also associated with higher eosinophil counts in D2 (P = 0.007) and symptoms of early satiety (P = 0.02). Duodenal eosinophilia occurs in a subset of FD. The potential role of duodenal eosinophils in FD has implications for diagnosis and therapeutic trials. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  8. Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: A double-blind randomized clinical trial

    Science.gov (United States)

    Ghoshegir, S. Ashraffodin; Mazaheri, Mohammad; Ghannadi, Alireza; Feizi, Awat; Babaeian, Mahmoud; Tanhaee, Maryam; Karimi, Mehrdad; Adibi, Peyman

    2014-01-01

    Background: We aimed to assess the effects of anise on quality of life (QOL) of patients with functional dyspepsia (FD) in a double-blind randomized clinical trial. Materials and Methods: Of 180 patients attending the gastroenterology clinic, 107 ones with the diagnosis of postprandial distress syndrome according to Rome III criteria were enrolled. They were randomized into two groups, anise and placebo. Anise group involved 47 patients and received anise powders, 3 g after each meal (3 times/day) for 4 weeks. Control group had 60 patients who received placebo powders (cornstarch), 3 g after each meal (3 times/day) for 4 weeks. The QOL was assessed by short-form (SF)-36 questionnaire. Mean scores of eight health domains of the two groups were compared at baseline and at the end of study. Results: The age, sex, body mass index, smoking history, tea and coffee drinking patterns of the two groups were not significantly different. All domains of SF-36 were similar between the two groups at baseline but were significantly different at week 12. At baseline, mean score of physical component summary was 159 in placebo group and 167 in anise group (P = 0.1). At week 12, the score was 141 in placebo group and 251 in anise group (P = 0.0001). Mean baseline score of mental component summary was 172 and 165 in placebo and anise groups, respectively (P = 0.1). At week 12, the score was 135 in placebo group and 233 in anise group (P = 0.0001). Conclusion: The current study revealed the effectiveness of anise in improvement of QOL in patients with FD. PMID:25709650

  9. Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study

    Science.gov (United States)

    Heidari, Zahra; Keshteli, Ammar Hassanzadeh; Feizi, Awat; Afshar, Hamid; Adibi, Payman

    2017-01-01

    Background/Aims Somatization may influence persistence and severity of symptoms in gastrointestinal diseases. Some studies suggest that somatization is associated with chronic uninvestigated dyspepsia (CUD); however, the association is unclear. We aimed to determine the association between the profiles of somatic complaints with CUD and its symptoms. Methods In a cross-sectional study conducted on 4763 Iranian adults, somatic complaints were assessed using a comprehensive 31-items questionnaire. Patients with CUD were identified by the Rome III diagnostic criteria. Profiles of somatic complaints were derived from factor analysis. Logistic regression analysis was used to assess the relationship between extracted profiles with CUD and its symptoms. Results CUD, bothersome postprandial fullness, early satiation, and epigastric pain or burning was identified in 723 (15.2%), 384 (8.1%), 302 (6.3%), and 371 (7.8%) of the study population. The frequency of all 31 somatic complaints was significantly higher in patients with CUD compared with controls (P < 0.001), and the most frequent was severe fatigue (45.1%). The profiles of somatic complaints were extracted in 4 domains, including “psychological”, “gastrointestinal”, “neuro-skeletal”, and “pharyngeal-respiratory”. The psychological (OR, 1.49; 95% CI, 1.44–1.54), gastrointestinal (OR, 2.22; 95% CI, 2.09–2.37), neuro-skeletal (OR, 1.52; 95% CI, 1.44–1.59), and pharyngeal-respiratory (OR, 2.09; 95% CI, 1.94–2.25) profiles were significantly associated with greater odds of CUD. Conclusions CUD and its symptoms are strongly associated with higher levels of somatic complaints and their related extracted profiles. This perhaps explains that why it can be difficult to treat, however further prospective investigations are required to confirm these associations. PMID:27503912

  10. Postprandial symptoms in dysmotility-like functional dyspepsia are not related to disturbances of gastric myoelectrical activity

    Directory of Open Access Journals (Sweden)

    A.S. Oba-Kuniyoshi

    2004-01-01

    Full Text Available Gastric dysrhythmias, such as tachy- or bradygastria, have been reported in patients with functional dyspepsia (FD, but their role in symptom production is uncertain. It is also not known whether gastric dysrhythmias in these patients can be elicited by physiological gastric distension with a meal. We investigated the relationships between symptoms after ingestion of different volumes of water following a test meal and gastric dysrhythmias in FD patients. Fourteen patients with dysmotility-like FD and 13 healthy volunteers underwent paired electrogastrography (EGG studies. Fasted subjects ingested 150 ml of yoghurt with either 150 ml (low volume or 300 ml (high volume water in random order. Fasting and fed EGGs with monitoring of symptoms were performed in both studies. Ten FD patients (71.4% reported upper abdominal discomfort and bloating after the low volume meal, but only one (7.1% presented an abnormal EGG (dominant frequency in the 2-4-cpm range: 58%. Following the high volume meal, 7 patients (50% had symptoms, but none had EGG abnormalities. No significant differences were found between FD patients and controls for any of the EGG variables, in any test. In FD patients with postprandial symptoms, the percentage of the EGG dominant frequency in the normal range (median, 84.6%; range, 76.0-100.0% was similar (P > 0.20 to that in those without symptoms (88.5%; 75.0-100.0%. We conclude that disturbances of gastric myoelectrical activity are unlikely to play a role in the origin of postprandial upper abdominal discomfort and bloating in dysmotility-like FD.

  11. The Association between Oral Hygiene and Gastric Pathology in Patients with Dyspepsia: a Cross-Sectional Study in Southeast Iran

    Science.gov (United States)

    Zahedi, Leili; Jafari, Elham; Torabi Parizi, Molook; Shafieipour, Sara; Hayat Bakhsh Abbasi, Mehdi; Darvish Moghadam, Sodaif; Zahedi, Mohammad Javad

    2017-01-01

    BACKGROUND Many studies have reported an association between periodontal infections and some systemic diseases such as respiratory and cardiovascular diseases. Some studies found a direct association between chronic gastritis caused by Helicobacter pylori (HP) infection and poor periodontal health. METHODS In a cross-sectional study from November 2014 to December 2015 in Kerman, the largest province in southeast Iran, patients with dyspepsia who were candidate for diagnostic upper gastrointestinal (GI) endoscopy were included in our study. Decayed, Missing, and Filled Teeth (DMFT) index and Loe plaque index that are two popular indexes in dental epidemiology were used to assess the oral health by a dentist before the upper GI endoscopy. According to the Loe plaque index, score: 0= no plaque, score: 1= a film of plaque attaching to the free gingival border and near area of the tooth, score: 2= moderate reposition of deposits within the gingival pocket, score :3= plenty of soft matter within the gingival pocket±on the tooth and gingival border. Scores ≤1, 2 and 3 equal to good, moderate, and poor oral hygiene, respectively. During upper GI endoscopy a total of six biopsy samples were taken from fundus, body, and antrum. A pathologist reported these samples according to Sidney’s classification into superficial gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia. RESULTS According to Sidney’s classification 77 (89.5%) patients had superficial gastritis, 3 (3.5%) had atrophic gastritis, and 6 (7%) had intestinal metaplasia. HP was found in 80.2% of the gastric mucosal biopsy samples. There were not statistically significant relationship between Sidney’s classification, presence of HP in gastric mucosal biopsies, and hygiene indicators (p>0.05). No relation was found between the DMFT index and superficial gastritis, atrophic gastritis, and intestinal metaplasia (p>0.05). Gastric infection with HP was found in 70%, 75%, and 100% of patients with

  12. Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria.

    Science.gov (United States)

    Xiao, Ying-Lian; Peng, Sui; Tao, Jin; Wang, An-Jiang; Lin, Jin-Kun; Hu, Pin-Jin; Chen, Min-Hu

    2010-12-01

    To determine the prevalence and symptom pattern of pathologic esophageal acid reflux (PEAR) in patients with functional dyspepsia (FD) using the Rome III criteria, and to explore the value of a proton pump inhibitor (PPI) test in distinguishing the patients with and those without PEAR among FD patients. Consecutive FD patients who fulfilled the Rome III criteria without predominant typical reflux symptoms (i.e., heartburn or regurgitation) were enrolled. All patients underwent upper endoscopy and an ambulatory 24-h pH monitoring. PEAR was defined as the percentage total time for which a pH value 4.2% in the distal esophagus. Then, patients were treated with rabeprazole 10 mg twice daily for 28 days. The symptom scores were measured by the frequency score multiplied by the severity scores of the predominant symptom before and at the end of the treatment, and the "PPI test" was defined as positive if the overall scores of the predominant dyspeptic symptom in the fourth week decreased by >50% compared with those of the baseline. One hundred eighty-six FD patients were enrolled, with predominant symptoms of epigastric pain (n=68), epigastric burning (n=47), bothersome postprandial fullness (n=54), and early satiation (n=17). The prevalence of PEAR was 31.7%, with the highest percentage (48.9%) in patients with epigastric burning as their predominant symptom. The prevalence of PEAR in patients with postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were 36.6% (26/71) and 28.7% (33/115), respectively. Overall, 63.4% were positive for the "PPI test"; the rates were 51.5, 85.0, 66.7, and 41.1% in patients with epigastric pain, epigastric burning, bothersome postprandial fullness, and early satiation as their predominant symptoms, respectively (χ(2)=17.59, P=0.001). The positive rates were 65.5 and 60.6% in patients with PDS and EPS, respectively (χ(2)=0.41, P=0.522). The sensitivity and specificity of the "PPI test" in distinguishing FD patients with

  13. Acute Anxiety and Anxiety Disorders Are Associated With Impaired Gastric Accommodation in Patients With Functional Dyspepsia.

    Science.gov (United States)

    Ly, Huynh Giao; Weltens, Nathalie; Tack, Jan; Van Oudenhove, Lukas

    2015-09-01

    Functional dyspepsia (FD) is associated with impaired gastric accommodation, as well as gastric hypersensitivity, delayed emptying, and psychosocial comorbidities. In healthy people, acute anxiety impairs gastric accommodation, which is traditionally quantified as the average increase in gastric volume after a meal over 1 hour. However, this quantification approach does not address the complex time course of the gastric accommodation response to a meal. We modeled gastric accommodation in patients with FD as a function of postprandial time, to investigate whether it is associated with psychosocial factors (state anxiety, anxiety disorder, depression) and gastric sensorimotor function (sensitivity, emptying). We studied gastric sensorimotor function in 259 consecutive patients diagnosed with FD based on Rome II at the University Hospitals Leuven from January 2002 through February 2009. Subjects underwent a gastric barostat and breath test; psychiatric comorbidity was assessed by questionnaires. Subjects completed the State-Trait Anxiety Inventory to measure levels of state anxiety immediately before and after gastric barostat analysis. The time course of the accommodation response was analyzed using mixed models. Psychological and sensorimotor variables were added to the model as continuous (state anxiety) or dichotomous (gastric sensitivity and emptying, anxiety disorders, depression) covariates, including their interaction with the time effects. In subjects with FD, delayed emptying (β = 50.3 ± 15.9; P = .002) and lower state anxiety (β = -1.7 ± 0.7; P = .012) were associated with an upward shift of the accommodation curve. There was a significant interaction between comorbid anxiety disorder and linear (β = 8.2 ± 3.5; P = .02), quadratic (β = -0.4 ± 0.1; P = .004), and cubic (β = 0.005 ± 0.002; P = .002) effects of time: patients with a comorbid anxiety disorder had significantly slower initial increases in gastric volume to a lower maximum

  14. Effects of a Herbal Medicine, Yukgunja-Tang, on Functional Dyspepsia Patients Classified by 3-Dimensional Facial Measurement: A Study Protocol for Placebo-Controlled, Double-Blind, Randomized Trial.

    Science.gov (United States)

    Kim, Juyeon; Park, Jae-Woo; Ko, Seok-Jae; Jeon, Soo-Hyung; Kim, Jong-Won; Yeo, Inkwon; Kim, Jinsung

    2017-01-01

    Introduction. Functional dyspepsia (FD), a common upper gastrointestinal disease, is difficult to manage because of the limitations of current conventional treatments. Yukgunja-tang (YGJT) is widely used to treat FD in clinical practice in Korea, Japan, and China. However, YGJT significantly improves few symptoms of FD. In Korean medicine, FD is a well-known functional gastric disease that shows difference in the effect of herbal medicine depending on constitution or type of Korean medicine diagnosis. This study aims to investigate the efficacy of YGJT on FD patients classified by 3-dimensional facial measurement using a 3-dimensional facial shape diagnostic system (3-FSDS). Methods. A placebo-controlled, double-blind, randomized, two-center trial will be performed to evaluate the efficacy of YGJT on FD patients. Eligible subjects will be initially classified as two types by 3-dimensional facial measurement using the 3-FSDS. Ninety-six subjects (48 subjects per each type) will be enrolled. These subjects will be randomly allocated into treatment or control groups in a 2 : 1 ratio. YGJT or placebo will be administered to each group during the 8-week treatment period. The primary outcome is total dyspepsia symptom scale, and the secondary outcomes include single dyspepsia symptom scale, proportion of responders with adequate symptom relief, visual analog scale, Nepean dyspepsia index-Korean version, functional dyspepsia-related quality of life, and spleen qi deficiency questionnaire. Discussion. This is the first randomized controlled trial to assess the efficacy of the YGJT on FD patients classified by 3-dimensional facial measurement. We will compare the treatment effect of the YGJT on FD patients classified as two types using the 3-FSDS. The results of this trial will help the FD patients improve the symptoms and quality of life effectively and provide objective evidence for prescribing the YGJT to FD patients in clinical practice. Trial Registration. This

  15. 针灸治疗功能性消化不良的配穴现状%Acupoint combination status of acupuncture and moxibustion on functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    李欣航; 陶晓雁; 朱光昭; 刘畅; 常日; 缪立辉

    2016-01-01

    The primary symptom of functional dyspepsia is epigastricpain, epigastric burning sensation, postprandial fullness, and early satiety. There are characteristics of chronicity, high relapse rate and difficult to alleviate, etc. In the treatment of functional dyspepsia, at present, western medicine gives priority to symptomatic treatment. Acupuncture treatment of functional dyspepsia is very unique. Shu-Mu point combination, Xi-Hui point combination, Xi-He point combination, He-Mu point combination, eight confluence points, distal-proximal point combination, the points selected according to syndrome differentiation and Yuan-Luo point combination, above methods are commonly used. And it also combined with other approaches, such as needles, moxibustion, cupping, ear acupuncture, elongated needle, electro-acupuncture, acupoint injection therapy, catgut implantation at acupoint, acupoint application, physical therapy and massage. The advantages of acupuncture are that it can relieve and cure multiple symptoms, enhance the quality of patients’ life and it has sure prospective efficacy.%功能性消化不良是以上腹痛、上腹烧灼感、餐后饱胀、早饱为主症,有慢性、易复发、难以缓解等特点,目前西药大多是对症治疗。针灸治疗功能性消化不良很有特色,常用俞募配穴、郄会配穴、郄合配穴、合募配穴、八脉交会穴、远近配穴、辨证取穴及原络配穴法,且毫针、灸法、罐、耳针、芒针、电针、穴位注射、穴位埋线、穴位贴敷、物理疗法、按摩多种方法配合应用,其优势在于能使多种症状缓解或消失,改善和提高患者生存质量,远期疗效确切。

  16. Irritable bowel syndrome and upper dyspepsia among the elderly: a study of symptom clusters in a random 70 year old population

    DEFF Research Database (Denmark)

    Kay, L; Jørgensen, Torben; Schultz-Larsen, K;

    1996-01-01

    later. The following clusters of symptoms were constantly associated. One group constituted abdominal distension, borborygmi, altering stool consistency and number of bowel movements. Pain relieved by bowel movement was associated with this cluster. Nausea and vomiting comprised another cluster......With the aim to assess the clustering of abdominal symptoms in a random population, data from a cohort study of a 70 year old Danish population were analysed. The cohort comprised 1,119 subjects of which 72% participated in a primary study and 91% of the survivors in a similar study five years....... Heartburn/acid regurgitation did not show a consistent association to any other symptoms and may be considered as a cluster of it own. Pain characteristics traditionally related to upper dyspepsia did not specifically relate to any cluster. It is concluded that, in this 70-year-old population abdominal...

  17. Can gastritis symptoms be evaluated in clinical trials? An overview of treatment of gastritis, nonulcer dyspepsia and Campylobacter-associated gastritis.

    Science.gov (United States)

    Veldhuyzen van Zanten, S J; Tytgat, K M; Jalali, S; Goodacre, R L; Hunt, R H

    1989-10-01

    We carried out a review of the literature on Campylobacter pylori-associated gastritis and nonulcer dyspepsia (NUD) to determine whether or not symptoms related to these conditions can be measured reliably and whether or not any study to date has shown that treatment alters symptoms. Search strategies consisted of online Medline searching, a forward search of three articles using the Science Citation Index, a manual search of five gastroenterological journals, and a fully recursive search of cited references. Inclusion and quality criteria were applied to all retrieved studies. Nine of 23 studies did not fulfill the inclusion criteria. Of the 14 studies analyzed, two measured symptoms reliably. Neither showed a therapeutic benefit on symptoms. The difficulties encountered in conducting such studies and the methods of recording symptoms reliably are discussed. We conclude that to date, no treatment is of proven benefit in the relief of symptoms associated with C. pylori gastritis and NUD.

  18. OP-6 INTRAGASTRIC PRESSURE MEASUREMENT DURING NUTRIENT INTAKE: A NOVEL MINIMALLY INVASIVE METHOD TO MEASURE GASTRIC ACCOMMODATION IN FUNCTIONAL DYSPEPSIA.

    Science.gov (United States)

    Carbone, F; J Tack; Hofmann, I

    2015-10-01

    Functional dyspepsia (FD) in pediatrics is defined as the presence of upper abdominal symptoms for at least 2 months in the absence of organic or metabolic disease likely to explain the symptoms. The main proposed pathophysiological mechanisms are visceral hypersensitivity,impaired gastric accommodation (GA) and delayed gastric emptying. At present, the gastric barostat is the gold standard to measure GA. However, this procedure is perceived as very invasive and it might alter the normal gastric physiology. Recently, we proposed the intragastric pressure (IGP) measurement during nutrient intake as a potential alternative for assessing GA in adults. This technique uses a thin manometry catheter that measures the IGP over the entire length of the stomach. By means of this study we aim to introduce the HRM as new minimally invasive technique to measure GA and nutrient tolerance in children. After the manometry probe and a second infusion catheter were positioned through the nose into the stomach, the IGP was measured 30 minutes before and during intragastric infusion of nutrient drink (300 Kcal, 60 ml per minute). The patients were asked to score hunger and satiation and 6 epigastric symptoms (fullness, nausea, belching of air, cramps in the abdomen, bloating and pain) at 5-minute intervals. The experiment ended when the volunteers scored maximal satiation at 1-minute intervals by using a graphic rating scale that combines verbal descriptors on a scale graded from 0-5 (1, threshold; 5, maximum satiety). For this study 13 FD pediatric patients (92% female, 14.8 ± 0.8 years old, BMI: 19.5 ± 0.8) and 12 young adult volunteers (100% female, 22.2 ± 0.4 years old, BMI: 21.2 ± 0.3) were recruited. The Rome III questionnaire showed that FD patients suffered mainly from postprandial fullness (75%), epigastric pain (58%), bloating (50%), nausea (50%) and early satiation (42%). In both groups, intragastric infusion of nutrient drink induced a rapid drop in

  19. Anti-CagA positivity in duodenal ulcer and functional dyspepsia patients infected with Helicobacter pylori and its effect on the outcome of eradication treatment

    Directory of Open Access Journals (Sweden)

    Yaşar Nazlıgül

    2011-03-01

    Full Text Available Objectives: CagA positive H. pylori strains are considered to be more virulent than other strains. In this study, we aimed to investigate the rate of CagA positivity in duodenal ulcer (DU and functional dyspepsia (FD, and its effect on H. pylori eradication response.Materials and methods: The study was performed on H. pylori positive 60 patients with DU and 50 patients with FD, who underwent upper gastrointestinal endoscopy. H. pylori infection was identified by histology. All patients received a quadriple therapy consisted of esomeprazole 20 mg b.i.d., colloidal bismuth subcitrate 600 mg b.i.d., tetracycline 500 mg q.i.d. and metronidazole 500 mg t.i.d. for 7 days. H.pylori status was rechecked using C14-urea breath test 6 weeks after the end of treatment to confirm cure. Specific IgG antibodies for CagA status were determined by enzyme linked immunosorbent assay.Results: CagA positivities in the patients with DU and FD were calculated respectivily 70% and 68% (P>0.05. H. pylori was eradicated in 85.5% of the patients infected with CagA (+ strains, in 50% of those infected with CagA (- strains (P=0.001. The eradication rates were 95.2% and 55.6% in CagA positive and negative DU subgroups (P=0.001, and 73.5% and 43.8% in CagA positive and negative FD subgroups (P=0.04.Conclusion: CagA positivities were not different in duodenal ulcer and functional dyspepsia. CagA (+ strains was susceptible to the eradication treatment. The titres of serum anti-CagA antibodies may be used in the prediction of eradication outcome, and the modification of eradication therapy.

  20. 中医治疗小儿消化不良的疗效分析%A clinical effective analysis of treating children dyspepsia in TCM

    Institute of Scientific and Technical Information of China (English)

    常英丽

    2015-01-01

    Objective:To study effect of TCM on Children dyspepsia. Method:The hospital in January 2014—December 2014 admitted 140 Children patients with dyspepsia were randomly divided into two groups and control group of the 70 cases, The observation group in TCM, and the control group in western medicine, Comparing two groups of curative effect and the appetite to eat score changes before and after the treatment. Result: In observation group total efficiency was higher than the control group, the differences were statistically significant ( P<0.05).Conclusion:TCM treatment for pediatric digestive show better clinical effect than western medicine treatment, and was suitable for clinical application.%目的:探讨中医治疗小儿消化不良的临床疗效。方法:将我院2014年1月—2014年12月收治的小儿消化不良患儿140例,随机分为2组各70例,分别采用中医治疗(治疗组)和西医治疗(对照组),观察比较两组治疗疗效及治疗前后食欲食量评分变化。结果:治疗组总有效率高于对照组,观察治疗后食欲食量评分低于对照组,差异均具有统计学意义(均P<0.05)。结论:中医治疗小儿消化不良临床效果较西医治疗好,临床症状改善明显,适合临床推广应用。

  1. Evaluation of the use of rapid urease test: Pronto Dry to detect H pylori in patients with dyspepsia in several cities in Indonesia

    Institute of Scientific and Technical Information of China (English)

    AF Syam; M Abdullah; AA Rani; S Nurdjanah; P Adi; A Djumhana; P Tarigan; IDN Wibawa

    2006-01-01

    AIM: To evaluate Pronto Dry examination in patients with dyspepsia.METHODS: The study was conducted in patients with dyspepsia who underwent endoscopic examination in several endoscopic centers of several cities in Indonesia from January 2003 until April 2004. Biopsies for histopathologic examination were fixed with formalin and sent to Histopathologic Department to be analyzed and confirm the presence of H pylori infection. If H pylori was found positive, the density was calculated semi quantitatively. Histopathologic examination from gastric biopsy samples was interpreted based on the updated Sydney system classification.RESULTS: Of 550 patients, 309 (56%) were male and 241 (44%) were female with ages ranging from 15 to 82years. Mean age was 44.98 ± 14.46 years. Mean age of male patients was 44.35 ± 13.85 years and mean age of female patients was 45.78 ± 15.19 years. Evaluation of endoscopic results showed gastric ulcer in 36 cases (6.5%) and duodenal ulcer in 20 cases (3.6%). Normal endoscopic finding was found in 45 cases (8.2%) and minimal disorder of gastritis and duodenitis were found in 246 cases (44.7%). One case of gastric cancer was identified. Of 56 cases which were positive based on the criteria used, 39 patients were positive with Pronto Dry and 17 patients were negative with Pronto Dry. Overall sensitivity and specificity of Pronto Dry were 69.7% and 95.7% respectively. Positive predictive value was 66.1%and negative predictive value was 96.4% and overall ac curate rate was 92.9%.CONCLUSION: Pronto Dry seems promising as a diagnostic tool to detect H pylori more rapidly and accurately.

  2. Evaluation of Clinical Manifestations and Therapeutic and Diagnostic Progression of Dyspepsia in Children Referred to Boo-Ali Hospital of Sari in 2005-2

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    H. Karami, M.D.

    2007-09-01

    Full Text Available Background and purpose: Chronic abdominal pain is a common clinical problem in children. Apleys reported the incidence of 10-15% of chronic abdominal pain in school age children, but recent studies reported 20% of that type of pain. The aim of this study was determining the spectrum of clinical manifestations of dyspeptic children and to identify the relation between some clinical symptoms, organic or functional dyspepsia, and long term follow up of functional type.Materials and Methods: This descriptive case series study was done on 232 children between 4 and 18 years of age complaining about chronic abdominal pain chiefly who had referred to pediatric gastroenterology department of Boo-Ali Hospital of sari in 2005-2006. A checklist composed of patient demographic criteria and pain characteristics was prepared. Physical exam and laboratory tests such as AST, ALT, U/A, U/C, S/E, ESR, CBC were performed for all patients. If there were any alarming signs of organic abdominal pain-persistence or recurrence of symptoms and severe disability despite the use of H-blockers-upper GI endoscopies was indicated. Recorded data were analyzed by SPSS software and Chi- square tests.Results: 102 of 232 patients had dyspepsia; 59 were girls (9.2y/o, and 43 were boys (7.5y/o. 65 out of 102 patients had dominant abdominal pain and the rest had flatulence, vomiting and early fullness. 64 of them went under UGI endoscopies. 28 of 64 had mucosal erosion.Conclusion: Because the functional or organic abdominal pain has not unique diagnostic criteria, and the data about pathological change in children are fewer than that of adults we recommend the clinical findings and biochemical change of mucosa for differential diagnosis in children.

  3. Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population

    Institute of Scientific and Technical Information of China (English)

    Kantarceken Bulent; Hilmioglu Fatih; Aladag Murat; Atik Esin; Koksal Fatih; Harputluoglu MMMurat; Harputluoglu Hakan; Karincaoglu Melih; Ates Mehmet; Yildirim Bulent

    2003-01-01

    AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients.

  4. Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and nonulcer dyspepsia subjects with histological changes

    Institute of Scientific and Technical Information of China (English)

    Mahaboob Ali; Aleem A Khan; Santosh K Tiwari; Niyaz Ahmed; L Venkateswar Rao; CM Habibullah

    2005-01-01

    AIM: To investigate the presence of the cay-pathogenicity island and the associated histological damage caused by strains with complete cay-PAI and with partial deletions in correlation to the disease status.METHODS: We analyzed the complete cag-PAI of 174representative Helicobacter pylori (H pylori ) clinical isolates obtained from patients with duodenal ulcer,gastric ulcer, gastric cancer, and non-ulcer dyspepsia using eight different oligonucleotide primers viz cagA1,cagA2, cagAP1, cagAP2, cagE, cagT, LEC-1, LEC-2spanning five different loci of the whole cag-PAI by polymerase chain reaction (PCR).RESULTS: The complete screening of the genes comprising the cag-PAI showed that larger proportions of subjects with gastric ulcer (97.8%) inhabited strains with complete cag-PAI, followed by gastric cancer (85.7%),non-ulcer dyspepsia (7.1%), and duodenal ulcer (6.9%),significant differences were found in the percentagedistribution of the genes in all the clinical groups studied.It was found that strains with complete cag-PAI were able to cause severe histological damage than with the partially deleted ones.CONCLUSION: The cay-PAI is a strong virulent marker in the disease pathogenesis as it is shown that a large number of those infected with strain with complete cag-PAI had one or the other of the irreversible gastric pathologies and interestingly 18.5% of them developed gastric carcinoma. The presence of an intact cayPAI correlates with the development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease. Partial deletions of the cag-PAI appear to be sufficient to render the organism less pathogenic.

  5. Digestive Enzyme for Dyspepsia: A Systematic Review%消化酶制剂治疗消化不良的系统评价

    Institute of Scientific and Technical Information of China (English)

    唐惠林; 栾嵘; 翟所迪

    2012-01-01

    Objective To evaluate the efficacy, safety and economics of digestive enzyme for dyspepsia. Methods Electronic databases such as PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), CBM, VIP and CNKI were searched from establishment dates of databases to June 2010 to identify the randomized controlled trials (RCTs) of digestive enzyme for dyspepsia. Then studies were identified according to predefined inclusion and exclusion criteria, and their quality was evaluated. The meta-analysis was performed using RevMan 5.0 software. Results Eight studies involving 1 092 patients were included, 3 of which were Grade B while the rest were Grade C. The results of the meta-analysis showed that the total efficacy rate of oryz-aspergillus enzyme and pancreatin tablet, compound digestive enzymes capsule, and compound azintamide enteric-coated tablet for dyspepsia were better than either placebo or blank intervention, with the results as (OR=49.70, 95%CI 17.16 to 143.96), (OR=7.71, 95%CI 3.88 to 15.33) and (OR=16.27, 95%CI 6.85 to 38.66), respectively. The efficacy for treating loss of appetite, abdominal distension, abdominal pain, diarrhea and belching was superior to either placebo or blank intervention. Oryz-aspergillus enzyme and pancreatin tablet was inferior to compound digestive enzyme capsule in treating dyspepsia following cholecystectomy. No significant difference was observed in treating dyspepsia following chronic pancreatitis between compound azintamide enteric-coated tablet and compound digestive enzymes capsule. Drug-related adverse reactions as well as economic evaluation were not reported in included studies. Conclusion Digestive enzyme is effective for dyspepsia caused by various diseases. The OR of digestive enzyme versus the placebo/blank-control group shows that oryz-aspergillus enzyme and pancreatin tablet is better than other digestive enzyme drugs.%目的 系统评价不同消化酶制剂治疗消化不良的疗效

  6. AN OPEN-LABEL MULTICENTER OBSERVATIONAL STUDY OF THE EFFICACY, TOLERABILITY, AND SAFETY OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG AMTOLMETIN GUACIL IN PATIENTS WITH KNEE OSTEOARTHRITIS AND DYSPEPSIA

    Directory of Open Access Journals (Sweden)

    E. S. Tsvetkova

    2016-01-01

    Full Text Available Objective: to investigate the efficacy and tolerability of amtolmetin guacil (AMG; Niselat®, Dr. Reddy's Laboratories Ltd, India versus previous therapy with nonsteroidal anti-inflammatory drugs (NSAIDs in patients with knee osteoarthritis (OA and signs of dyspepsia.Subjects and methods. The open-label observational study included 220 patients aged 30–65 years who suffered from knee OA and intense pain during NSAID intake and had symptoms of dyspepsia in the absence of contraindications to the use of AMG. Among the comorbidities that generally occurred in 68% of the patients, there was a preponderance of hypertension (42%, lower extremity varicose veins (6.4%, and diabetes mellitus (6%. Treatment efficacy was evaluated using three domains of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC, by also taking into account pain intensity and general health assessment on the visual analogue scale. A Severity of Dyspepsia Assessment (SODA scale was used to rate dyspepsia.Results and discussion. AMG had a marked analgesic effect confirmed by 40% or more pain reduction that occurred in 72.5% of the patients. The high analgesic effect of AMG was confirmed by a statistically significant (p <0.001 reduction in the WOMAC index (pain and stiffness and by an increase in functional activity. There was a significant decrease in painless and painful signs of dyspepsia, as well as positive changes in the measures “overall assessment of dyspepsia severity” (p < 0.001 and “satisfaction with treatment”. Overall assessment of AMG tolerability was only positive: excellent (33%, good (56%, and satisfactory (11%. There were no serious adverse events (AE. AE were graded as moderate and mild in 8 and 82% of cases, respectively. AE were recorded in 7.7% of the patients. Conclusion. The findings suggest that AMG offers good prospects for knee OA treatment.

  7. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: a prospective, randomized, double blind, and placebo-controlled study5

    DEFF Research Database (Denmark)

    Kupcinskas, L.; Lafolie, P.; Lignell, A.;

    2008-01-01

    OBJECTIVES: The aim of this study was to evaluate the efficacy of the natural antioxidant astaxanthin in functional dyspepsia in different doses and compared with placebo. DESIGN: The study was a controlled, prospective, randomized, and double blind trial. PARTICIPANTS: Patients with functional d...... greater reduction of reflux symptoms were detected in patients treated with the highest dose of the natural antioxidant astaxanthin. The response was more pronounced in H. pylori-infected patients Udgivelsesdato: 2008/6...

  8. 南宁市大学生消化不良与精神心理和社会因素的关系%Relationships of psychological and social factors on dyspepsia of the college students in Nanning city

    Institute of Scientific and Technical Information of China (English)

    左国文; 齐晶晶; 梁列新; 叶会兰; 郭先文; 张法灿

    2016-01-01

    Objective To investigate the prevalence of dyspepsia and the relationship between dyspepsia,psychological and social factors among the college students in Naning city,and to improve the prevention and treatment of dyspepsia in this region.Methods Rome Ⅲ diagnostic questionnaire for adult dyspepsia,Chinese college student mental health scale (CCSMHS),Chinese college student psychological stress scale (CCSPSS),Chinese college student adaptation scale (CCSAS) and Chinese college student personality scale (CCSPS) were performed through interview survey in 2 580 Nanning college students.Chi square test and rank sum test were used to compared differences between groups.Correlation analysis was performed by Pearson correlation and Logisitic regression analysis.Results A total of 2 520 qualified Rome m questionnaires were recovered.The prevalence of dyspepsia in Nanning college students was 5.36%(135/2 520).The most common appearance of dyspepsia in college students were dislike of drinking tea (86.96%(100/115) vs 79.10%(1 605/2 029)),dislike of pickled food (85.22%(98/115) vs 76.29%(1 548/2 029)) and missing meals (40.87%(47/115) vs 30.31%(615/2 029)),the differences were statistically significant (x2 =4.122,4.860,5.685;all P<0.05),while the dyspepsia was not related with drinking,smoking and taking raw,cold or spicy food (all P>0.05).The results of multifactor regression analysis showed that the prevalence of dyspepsia was not correlated with diet.Among the twelve dimensions of psychological health,the somatization,anxiety,depression,low self-esteem,social withdrawal,sexual psychology,paranoia,force,dependency,psychotic tendencies of dyspepsia group were significantly higher than those with non-dyspepsia group (x2 =16.981,21.805,12.520,13.539,6.998,6.154,15.013,9.457,10.715,4.260,all P<0.05).Among the seven dimensions of psychological stress,study pressure and development pressure were negative life events,and their of dyspepsia group were

  9. Masaje Tuina en el tratamiento de la dispepsia funcional en los niños Tuina massage in the treatment of functional dyspepsia in children

    Directory of Open Access Journals (Sweden)

    Lesbia Infante Tamayo

    2008-03-01

    the Chinese traditional medicine. The aim of this paper was to show the efficacy of the Tuina massage in the treatment of functional dyspepsia in children. METHODS. A controlled clinical trial was conducted among patients with functional dyspepsia that met the previously established inclusion criteria. The sample consisted of 100 patients divided into 2 groups: group A with patients that were applied massage, and group B that was made up of patients that received conventional treatment. The technique used was push and massage (tonification and dispersion. The stimulated zones were Ban Men, Zhong Wan (Vc12, ZusanLi (E36, San Guan, Liu Fu. The conventional treatment consisted in the administration of metoclopramide at doses of 0.1 mg/kg every 8 hours by intramuscular route. Once the emetic picture was controlled, the same drug was orally administered and with the same frequency. Both groups were evaluated at 12, 24, 48, 72 h of the initial treatment. RESULTS. The response to the conventional treatment was higher in the study group (48; 96 % compared with the control group (46; 92 %, but the differences were not statistically significant. The complications found were extrapyramidal reactions and skin irritation, but the differences between the 2 groups were not marked either. The length of hospital stay of most of the patients was between 25 and 48 hours. CONCLUSIONS. It was concluded that the Tuina massage is as efficient as the conventional treatment for controlling functional dyspepsia in children.

  10. Personality traits in patients referred for functional dyspepsia%功能性消化不良就诊患者的人格特征研究

    Institute of Scientific and Technical Information of China (English)

    韩麦; 段丽萍; 黄悦勤; 葛颖; 郝靖欣; 王琨

    2010-01-01

    Objective To assess the prevalence of Personality Diagnostic Questionnaire (PDQ)personality deviations in patients referred for functional dyspepsia (FD) with reliable and universal psychological measures, and to explore the relationship between co-occurring PDQ-personality deviations and functional dyspepsia. Methods The sample comprised 246 patients referred for functional dyspepsia. Four groups were divided according to their patterns of gastrointestinal symptoms: the FD group, FD with refluxlike symptom group(FD + RS group), FD with irritable bowel syndrome group( FD + IBS group), and FD with reflux-like symptom and irritable bowel syndrome group ( FD + RS + IBS group). Participants were assessed with the Personality Diagnostic Questionnaire for DSM-Ⅳ ( PDQ-4 ) to evaluate the presence of personality deviations. Results Overall 65% patients scored positive for any personality deviation, male and female alike. Cluster C (anxious/fearful) personality was most commonly found in FD patients (142 patients, 57.7% ). The FD + IBS group and the FD + RS +IBS group had significantly higher total PDQ scores than the FD group (23.39 ± 8. 77 and 24. 22 ± 10. 97 vs 18.98 ± 11.88, P < 0. 05, respectively),indicating that FD patients with greater level of personality deviations tend to report other symptoms involving the esophagus and lower gastrointestinal tract. Reflux-like symptom without actual pathological acid regurgitation indicated cluster A (odd/eccentric) personality deviations. Conclusions The current study shows personality deviations are common in patients referred for functional dyspepsia. Negative emotions,maladaptive coping, and lack of social support, may strongly influence their healthcare-seeking behavior.There is no single personality type specific for some kind of gastrointestinal symptom. But FD patients with personality deviations tend to report other symptoms involving the esophagus and lower gastrointestinal tract.%目的 使用通用、可靠

  11. Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylori eradication treatments from those with peptic ulcer disease? A systematic review

    Institute of Scientific and Technical Information of China (English)

    Jia-Qing Huang; Ge-Fan Zheng; Richard H Hunt; Wai-Man Wong; Shiu-Kum Lam; Johan Karlberg; Benjamin Chun-Yu Wong

    2005-01-01

    AIM: It is controversial whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori (H pylori) eradication treatment than those with peptic ulcer disease (PUD). To review the evidence for any difference in H pylori eradication rates between PUD and NUD patients. METHODS: A literature search for full articles and meeting abstracts to July 2004 was conducted. We included studies evaluating the efficacy of a proton pump inhibitor (P) or ranitidine bismuth citrate (RBC) plus two antibiotics of clarithromycin (C), amoxicillin (A), metronidazole (M), or P-based quadruple therapies for eradicating theinfection.RESULTS: Twenty-two studies met the criteria. No significant difference in eradication rates was found between PUD and NUD patients when treated with 7-d RBCCA, 10-d PCA or P-based quadruple therapies. When the 7-d PCA was used, the pooled H pylori eradication rate was 82.1% (431/525) and 72.6% (448/617) for PUD and NUD patients, respectively, yielding a RR of 1.15(95%CI 1.01-1.29). However, the statistically significant difference was seen only in meeting abstracts, but not in full publications.CONCLUSION: There is no convincing evidence to suggest that NUD patients respond to H pylori eradication treatments differently from those with PUD, although a trend exists with the 7-d PCA therapy.

  12. Impact of pediatric Rome III criteria of functional dyspepsia on the diagnostic yield of upper endoscopy and predictors for a positive endoscopic finding.

    Science.gov (United States)

    Tam, Yuk Him; Chan, Kin Wai; To, Ka Fai; Cheung, Sing Tak; Mou, Jennifer Wai Cheung; Pang, Kristine Kit Yi; Wong, Yuen Shan; Sihoe, Jennifer Dart Yin; Lee, Kim Hung

    2011-04-01

    Pediatric Rome III criteria of functional dyspepsia (FD) has eliminated the mandatory use of upper endoscopy and recommended a symptom-based approach. In the absence of alarm symptoms, FD can be positively diagnosed in children having normal physical findings without exclusionary investigations. We aimed to investigate the effectiveness of Rome III guidelines to discriminate organic diseases from FD and to identify the predictors for positive endoscopic findings. A prospective study was conducted on consecutive children fulfilling Rome III criteria of FD. Upper endoscopy was performed in all subjects, both with and without alarm features. Eighty consecutive children ages 7 to 15 were recruited. Nine (11.3%) had experienced alarm features. Five (6.3%) had organic diseases confirmed in upper endoscopy: duodenal ulcer (n = 2), duodenitis with erosion (n = 2), and gastritis with erosion (n = 1), 33.3% of children having alarm features had organic pathology, compared with 2.8% of those without (P Rome III recommendations of screening dyspeptic children for alarm features and investigation for H pylori are effective to identify children who have a higher likelihood of organic diseases and require upper endoscopy before making a diagnosis of FD.

  13. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach.

    Science.gov (United States)

    Yoshii, Kazuyoshi; Iikura, Minami; Hirayama, Masamichi; Toda, Ryoko; Kawabata, Yoshihiro

    2016-02-01

    Acotiamide, a gastroprokinetic agent used to treat functional dyspepsia, is transported to at least two compartments in rat stomach. However, the role of these stomach compartments in pharmacokinetics and pharmacodynamics of acotiamide remains unclear. Thus, the purpose of this study was to elucidate the relationship of the blood and stomach concentration of acotiamide with its inhibitory effect on acetylcholinesterase (AChE). Concentration profiles of acotiamide and acetylcholine (ACh) were determined after intravenous administration to rats and analyzed by physiologically-based pharmacokinetic and pharmacodynamic (PBPK/PD) model containing vascular space, precursor pool and deep pool of stomach. Acotiamide was eliminated from the blood and stomach in a biexponential manner. Our PBPK/PD model estimated that acotiamide concentration in the precursor pool exceeded 2 μM at approximately 2 h after administration. Acotiamide inhibited AChE activity in vitro with a 50% inhibitory concentration of 1.79 μM. ACh reached the maximum concentration at 2 h after administration. Our PBPK model well described the profile of acotiamide and ACh concentration in the stomach in the assumption that acotiamide was distributed by carrier mediated process and inhibited AChE in the precursor pool of stomach. Thus, Acotiamide in the precursor pool plays an important role for producing the pharmacological action.

  14. Study for functional dyspepsia pathological physiological mechanism%功能性消化不良病理生理机制研究进展

    Institute of Scientific and Technical Information of China (English)

    赵丹; 毛华

    2014-01-01

    Functional dyspepsia (FD) is a most common form of clinical functional digestive disease whose pathogenesis is still unclear. Currently the major view is that FD is correlated with gastrointestinal motility, helicobacter pylori, psychology, brain-gut axis. Currently the brain-gut axis and its related gastrointestinal hormones are drawing much attention. Here is to review the recent progress in pathogenesis of FD with emphasis is on Brain-gut axis.%功能性消化不良(FD)是临床最常见的功能性胃肠疾病,其发病机制尚不清楚,目前多数研究认为FD的发病可能与胃动力紊乱、胃酸分泌异常、幽门螺杆菌(Hp)感染、胃肠激素、精神心理因素等密切相关。近年来脑肠轴以及其相关的胃肠激素在FD发病机制中的作用备受关注。本文就近年来有关FD的病理及生理发病机制的研究进行综述。

  15. Clinical Studies on Functional Dyspepsia Treated with Different Dosage-Form of Zhishi Xiaopi Pill Recipe (枳实消痞丸方)

    Institute of Scientific and Technical Information of China (English)

    窦丹波; 蔡淦; 王松坡; 倪克中; 唐静芬

    2002-01-01

    Objective: To explore the clinical effect of three different dosage-forms of Zhishi Xiaopi Pill (ZSXPP, 枳实消痞丸) recipe on functional dyspepsia (FD). Methods: The total of 158 patients were included in this study and were randomly divided into four groups. Three group patients of FD were respectively treated with three different dosage-forms of ZSXPP, while the control group were treated with cisapride. Results: The treatment outcome indicated that there was no difference in the total therapeutic efficacies of these four groups. The tension of vagus nerve and the plasma level of motilin in FD patients were significantly increased by the treatment with ZSXPP; the impaired contraction function of lower esophageal sphincter in some FD patients was improved, too. Conclusion: All of three different dosage-forms of ZSXPP were as effective as cisapride on FD. The efficacy was partly due to the improvement of esophageal and gastric dynamics which was probably related to the increasing of the tension of vagus nerve and the plasma level of motilin.

  16. Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection.

    Science.gov (United States)

    Maity, Abhijit; Pal, Mithun; Maithani, Sanchi; Ghosh, Barnali; Chaudhuri, Sujit; Pradhan, Manik

    2016-07-22

    The gastric pathogen Helicobacter pylori utilizes molecular hydrogen (H2) as a respiratory substrate during colonization in the gastric mucosa. However, the link between molecular H2 and the pathogenesis of peptic-ulcer disease (PUD) and non-ulcerous dyspepsia (NUD) by the enzymatic activity of H. pylori still remains mostly unknown. Here we provide evidence that breath H2 excretion profiles are distinctly altered by the enzymatic activity of H. pylori for individuals with NUD and PUD. We subsequently unravelled the potential molecular mechanisms responsible for the alteration of H2 in exhaled breath in association with peptic ulcers, encompassing both gastric and duodenal ulcers, along with NUD. We also established that carbon-isotopic fractionations in the acid-mediated bacterial environment regulated by bacterial urease activity cannot discriminate the actual disease state i.e. whether it is peptic ulcer or NUD. However, our findings illuminate the unusual molecular H2 in breath that can track the precise evolution of PUD and NUD, even after the eradication of H. pylori infection. This deepens our understanding of the pathophysiology of PUD and NUD, reveals non-invasively the actual disease state in real-time and thus offers a novel and robust new-generation strategy for treating peptic-ulcer disease together with non-ulcer related complications even when the existing (13)C-urea breath test ((13)C-UBT) fails to diagnose.

  17. 海军部队人员功能性消化不良及影响因素%Research on functional dyspepsia prevalence and related factors of naval

    Institute of Scientific and Technical Information of China (English)

    崔立红; 闫志辉; 彭丽华; 于兰; 杨云生

    2013-01-01

    Objective To analyze functional dyspepsia prevalence and associated factors of naval forces.Method By stratified random cluster sampling method,conducted a questionnaire survey and diagnosis of functional dyspepsia to 11 520 military sea forces,and analyzed risk in clinical factors.Large sample size of 3084 cases in the diagnosis of functional dyspepsia,analyzed correlation of the selected 100 patients by single sample random sampling method.Result Naval forces,functional dyspepsia prevalence was 29.27% (3084/10537),and logistic regression analysis showed that job factors of military service,military rank,the nature of the work,the training intensity,training environmental P=0.028,0.023,0.000,0.000,0.014,OR=10.308,6.288,22.504,26.720,9.825; life factors of daily water intake,eating fruits and frequency of sleep time,spicy eating habits,drinking history factors P=0.000,0.012,0.025,0.017,0.027,OR =28.467,20.335,11.358,10.249,9.578; psychological factors,depression,anxiety factor P=0.024,0.019,OR =16.878,18.025;generally age,gender,ethnicity,BMI index,gastrointestinal history,history of drug,educational background,geographic factors P=0.042,0.033,0.417,0.000,0.000,0.012,0.392,0.440,OR =3.406,7.511,2.643,42.073,88.457,21.680,1.752,5.561.When value of P<0.05,clinical risk factors were screened.Clinical symptom scores and work,life factor score and SAS,SDS score of randomly selected patient samples was positively correlated,r=0.816、0.763、0.795、0.923,P=0.000,indicating statistically significant.Conclusion Naval forces functional dyspepsia prevalence was higher than the general population,which risk factors included work,life,psychological,physical fitness factors,closely related with military service and military personnel,military rank,the nature of the work,the training intensity and environment,eating habits,daily sleep time,drinking history,depression,anxiety level,age,gender,BMI index,history of gastrointestinal disease,use of drugs,high priority should be

  18. An epidemiologic study of functional dyspepsia in Chinese adolescents%全国城市中、小学生功能性消化不良现况调查

    Institute of Scientific and Technical Information of China (English)

    宗春华; 周惠清; 李定国; 宋艳艳; 胡颖; 许小幸; 陆汉明

    2008-01-01

    Objective To analyze the clinical presentation of functional dyspepsia in Chinese ado lescents.Methods A stratified,randomized study by cluster sampling was employed,which recruited 51 956 students from high and primary schools in six provinces and two cities.All students were requested to fill in a questionnaire.Functional dyspepsia was diagnosed according to Rome Ⅱ criteria.Results Among 51 956 students,10 174 were diagnosed as functional dyspepsia(accounted for 19.58%).Heart burn,hiccup and air swallowing to terminate hiccup were major symptoms of functional dyspepsia.The upper abdominal distention,epigastric pain,anorexia and insomnia were common in boys than girls with no significance(P>0.05).The belching,early satiety,fatigue and anxiety were significantly higher in girls than boys.Conclusions Functional dyspepsia is a common disorder among the adolescents.Educa-tion and psychotherapy are important in the treatment of students with functional dyspepsia.%目的 分析我国城市中、小学生功能性消化不良的临床特点.方法 采用多级整群随机抽样方法,于2005年5月至2006年1月按罗马Ⅱ标准诊断功能性消化不良对我国六个省及两个直辖市中51 956名中、小学生进行流行病学问卷调查.结果 51 956名学生中有10 174名符合罗马Ⅱ标准诊断功能性消化不良,占19.58%.烧心、打嗝即采用吞气来终止打嗝是青少年主要的功能性消化不良症状.上腹胀在男生中高于女生,上腹痛、纳差及失眠在女生中高于男生,但两者差异均无统计学意义(P>0.05).嗳气、早饱、疲劳及心情焦虑烦躁在女生中高于男生,两者间差异有统计学意义(P<0.05).结论 功能性消化不良是城市中、小学生.的常见病及多发病,在治疗中应着重加强认知教育及心理治疗.

  19. 温针灸治疗脾胃气虚型功能性消化不良疗效评价%The Therapeutic Evaluation of Warm Needling Method for Spleen Stomach Qi Deifciency Type of Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    赵莉; 赵欲晓

    2016-01-01

    Objective To study the effect of warm needling treatment for spleen stomach qi deficiency type of functional dyspepsia.Methods58 patients with spleen and stomach qi deifciency type of functional dyspepsia in our hospital, were randomly divided into two groups, each 29 cases. Giving oral administration of domperidone tablets for the control group, the treatment group used the warm needling method based on the above treatment, to compare the treatment effect of them.Results The total effective rate of the treatment group was higher than the control group. There was statistical significance (P<0.05).Conclusion The warm needling treatment for spleen stomach qi deifciency type of functional dyspepsia is able to increase the total effective rate of treatment and improve the living standard of patients.%目的:研究温针灸治疗脾胃气虚型功能性消化不良的效果。方法选择来我院治疗脾胃气虚型功能性消化不良的患者58例,随机将其分成两组,每组29例。对照组口服多潘立酮片,实验组在上述治疗基础上实施温灸治疗。对比两组治疗效果。结果实验组总有效率高于对照组,差异有统计学意义(P<0.05)。结论采用针灸治疗脾胃气虚型功能性消化不良可以提高治疗的总有效率,改善患者生活水平。

  20. 生长激素释放肽在功能性消化不良中的研究进展%Research progress of ghrelin on the functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    吕林(综述); 黄穗平; 唐旭东(审校)

    2014-01-01

    Functional dyspepsia is a common functional gastrointestinal disease , however , the cause of functional dyspepsia has not been fully elucidated .Ghrelin is braingut petide , secreted by major endocrine cells of the stomach ( x/A like cells ) .Its recep-tor is widely distributed in the body .It has many kinds of biological effects , such as regulating growth hormone secretion , feeding and energy balance , affecting neuroendocrine and gastrointestinal function and so on .A growing number of studies have shown that Ghrelin in FD has a positive role in increasing the improvement of food intake and generating hunger , promoting gastric emptying .Ghrelin is a new hot spot in the research of FD .%功能性消化不良( functional dyspepsia , FD)是一种常见的功能性胃肠道疾病,造成FD的病因目前尚未完全阐明。生长激素释放肽( Ghrelin)是一种主要由胃的内分泌细胞( X/A样细胞)分泌的脑肠肽。受体在体内广泛分布,具有调节生长激素分泌、摄食和能量平衡,影响神经内分泌及胃肠功能等多种生物学作用。越来越多的研究表明Ghrelin在FD中对于提高摄食量、产生饥饿感及促进胃排空方面有积极作用。目前,Ghrelin已成为研究FD的新热点。

  1. Analysis of vacA, cagA, and IS605 Genotypes and Those Determined by PCR Amplification of DNA between Repetitive Sequences of Helicobacter pylori Strains Isolated from Patients with Nonulcer Dyspepsia or Mucosa-Associated Lymphoid Tissue Lymphoma

    OpenAIRE

    van Doorn, Nathalie E. M.; Namavar, Ferry; Doorn, Leen-Jan; Durrani, Zarmina; Kuipers, Ernst J; Vandenbroucke-Grauls, Christina M. J. E.

    1999-01-01

    The vacA s and m genotypes and the presence of cagA and IS605 were determined in Helicobacter pylori strains from patients with mono- and multiple infections. Surprisingly, these genetic markers were not associated with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. The presence of cagA correlated with the presence of the vacA s1 allele (P < 0.05), whereas the presence of IS605 was associated with the presence of the s2 allele (P < 0.05).

  2. Eradication of Helicobacter pylori infection in patients with duodenal ulcer and non-ulcer dyspepsia and analysis of one-year reinfection rates

    Directory of Open Access Journals (Sweden)

    Della Libera E.

    2001-01-01

    Full Text Available Helicobacter pylori (HP infection is endemic worldwide. The proposed treatment is expensive and there are few reports regarding reinfection rates in Brazil. The aim of this study was to compare the eradication rates obtained with two therapeutic options and to evaluate reinfection one year after treatment. This was a prospective randomized trial with 55 patients. Thirty-nine patients had active duodenal ulcer (DU and 16 non-ulcer dyspepsia (NUD, and all tested positive for HP. Diagnosis was based on at least two positive tests: ultrarapid urease test, histology and/or culture. Patients were randomized to two groups: group OMC treated with 40 mg omeprazole (once a day, 500 mg metronidazole and 250 mg clarithromycin (twice daily for 7 days, or group NA treated with 300 mg nizatidine (once a day and 1000 mg amoxicillin (twice daily for 14 days. Those patients in whom HP was eradicated were followed up for one year to evaluate reinfection. Twenty-five patients were randomized for OMC and 30 for NA. HP eradication occurred in 20/25 patients (80% treated with OMC and 13/30 (43% treated with NA (P = 0.01. After reallocation because of initial treatment failure, the overall eradication rate was 44/51 patients (86%. After an average follow-up of one year, we evaluated 34 patients (23 with DU and 11 with NUD. Reinfection occurred in 3/34 patients (7.6%. We conclude that OMC is effective for HP eradication, and that NA should not be used. Reinfection occurs in 7.6% of the patients in the first year after eradication.

  3. Clinical classification of subgroups according to the Rome III criteria cannot be used to distinguish the associated respective pathophysiology in Japanese patients with functional dyspepsia.

    Science.gov (United States)

    Ochi, Masahiro; Tominaga, Kazunari; Tanaka, Fumio; Tanigawa, Tetsuya; Yamagami, Hirokazu; Watanabe, Kenji; Watanabe, Toshio; Fujiwara, Yasuhiro; Arakawa, Tetsuo

    2013-01-01

    Patients who meet the Rome III criteria for functional dyspepsia (FD) are generally classified into the following two subgroups, those with postprandial distress syndrome (PDS) and those with epigastric pain syndrome (EPS), in order to treat the dyspeptic symptoms caused by the respective pathophysiological conditions. However, whether simple classification of FD can accurately distinguish the pathophysiological differences between PDS and EPS remains to be clarified because the pathophysiology of FD is characterized and complicated by various factors. After classifying FD patients who were not receiving medication at the initial visit, we assessed and compared the following pathophysiological factors between the PDS and EPS groups: (1) the gastric reservoir and emptying functions using a radioisotope method (n=75), (2) the autonomic nervous system (ANS) function using electrocardiography (n=45), (3) gastric mucosal atrophy and intestinal metaplasia using histological examinations (n=47), (4) endoscopic findings of the stomach, such as superficial changes, abnormal gastroesophageal flap valves (n=67) and (5) Helicobacter pylori infection (n=48). The FD patients exhibited higher rates of an impaired reservoir function (49.3%), gastric emptying disorders (54.7%) and relative hyperactivity of the sympathetic nervous system (31.9%) than the control subjects. However, endoscopic and histological changes of the stomach were similar in both the FD patients and control subjects. In addition, no differences were observed in the above-mentioned factors between the PDS and EPS groups. The simple classification of FD patients into two subgroups according to the Rome III criteria following diagnosis does not indicate any differences in the pathophysiology related to the respective dyspeptic symptoms of FD patients.

  4. Characteristics of Japanese patients with chronic gastritis and comparison with functional dyspepsia defined by ROME III criteria: based on the large-scale survey, FUTURE study.

    Science.gov (United States)

    Kinoshita, Yoshikazu; Chiba, Tsutomu

    2011-01-01

    To clarify the clinical characteristics of patients diagnosed with chronic gastritis in Japan, a large scale clinical survey of patients with chronic upper gastrointestinal symptoms was conducted. Patients diagnosed with functional dyspepsia (FD) according to the ROME III criteria were selected from among patients with chronic gastritis and the clinical characteristics of patients with FD and those with chronic gastritis were compared. Patients with upper abdominal symptoms and diagnosed with chronic gastritis were enrolled in the study. Their main complaints, duration of symptoms, clinical characteristics, mental state, and results of endoscopic examinations, if available, were prospectively surveyed. Quality of life (QOL) impairment caused by abdominal symptoms was also surveyed using the Izumo QOL scale. A total of 9,125 patients with a clinical diagnosis of chronic gastritis were enrolled in the survey. Of those, approximately 60% had more than 2 symptoms and QOL impairment was greater in cases with multiple symptoms. Endoscopic examinations were performed in 2,946 cases (32.3% of enrolled patients), during which gastric and/or esophageal carcinoma was found in only 0.2%, though organic diseases were found in 6.2%. Endoscopic examinations were not done for patients with high risks of organic diseases. Of patients with organic diseases excluded by an endoscopic examination, only 362 (12.3% of patients who underwent an endoscopy) were diagnosed with FD according to the ROME III criteria, mainly because of short symptom duration. There were no remarkable differences in regard to clinical characteristics, including symptoms and mental state, between patients with chronic gastritis and those with FD. Clinical characteristics of patients with chronic gastritis were similar to those with FD, except for shorter symptom duration.

  5. The Effect of Ginger (Zingiber officinalis and Artichoke (Cynara cardunculus Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Attilio Giacosa

    2015-01-01

    Full Text Available Objective. Functional dyspepsia (FD is a frequent clinical finding in western world. The aim of this study is to compare the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD. Methods. A prospective multicentre, double blind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed. Two capsules/day were supplied (before lunch and dinner to 126 FD patients (supplementation/placebo: 65/61. Results. After 14 days of treatment, only supplementation group (SG showed a significant amelioration (SG: αS=+1.195 MCA score units (u, P=0.017; placebo: αP=+0.347 u, P=0.513. The intercept (α resulted to be significantly higher in SG than in placebo (αS-αP=+0.848 u, P<0.001. At the end of the study, the advantage of SG versus placebo persists without variation (βS-βP=+0.077 u, P=0.542. In SG, a significant advantage is observed for nausea (βS-βP=-0.398 u, P<0.001, epigastric fullness (βS-βP=-0.241, P<0.001, epigastric pain (βS-βP=-0.173 u, P=0.002, and bloating (βS-βP=-0.167 u, P=0.017. Conclusions. The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease.

  6. Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model

    Science.gov (United States)

    Qiu, Juan-Juan; Liu, Zhe; Zhao, Peng; Wang, Xue-Jun; Li, Yu-Chun; Sui, Hua; Owusu, Lawrence; Guo, Hui-Shu; Cai, Zheng-Xu

    2017-01-01

    AIM To investigate gut microbial diversity and the interventional effect of Xiaoyaosan (XYS) in a rat model of functional dyspepsia (FD) with liver depression-spleen deficiency syndrome. METHODS The FD with liver depression-spleen deficiency syndrome rat model was established through classic chronic mild unpredictable stimulation every day. XYS group rats received XYS 1 h before the stimulation. The models were assessed by parameters including state of the rat, weight, sucrose test result and open-field test result. After 3 wk, the stools of rats were collected and genomic DNA was extracted. PCR products of the V4 region of 16S rDNA were sequenced using a barcoded Illumina paired-end sequencing technique. The primary composition of the microbiome in the stool samples was determined and analyzed by cluster analysis. RESULTS Rat models were successfully established, per data from rat state, weight and open-field test. The microbiomes contained 20 phyla from all samples. Firmicutes, Bacteroidetes, Proteobacteria, Cyanobacteria and Tenericutes were the most abundant taxonomic groups. The relative abundance of Firmicutes, Proteobacteria and Cyanobacteria in the model group was higher than that in the normal group. On the contrary, the relative abundance of Bacteroidetes in the model group was lower than that in the normal group. Upon XYS treatment, the relative abundance of all dysregulated phyla was restored to levels similar to those observed in the normal group. Abundance clustering heat map of phyla corroborated the taxonomic distribution. CONCLUSION The microbiome relative abundance of FD rats with liver depression-spleen deficiency syndrome was significantly different from the normal cohort. XYS intervention may effectively adjust the gut dysbacteriosis in FD. PMID:28223725

  7. The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test

    Energy Technology Data Exchange (ETDEWEB)

    Braak, Breg; Klooker, Tamira K. [Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam (Netherlands); Booij, Jan [Academic Medical Center, Department of Nuclear Medicine, Amsterdam (Netherlands); Wijngaard, Rene M.J. van den [Academic Medical Center, Tytgat Institute of Liver and Intestinal Research, Amsterdam (Netherlands); Boeckxstaens, Guy E.E. [Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam (Netherlands); University Hospital Leuven, Catholic University Leuven, Department of Gastroenterology, Leuven (Belgium)

    2012-04-15

    Functional dyspepsia (FD) is a chronic condition characterized by upper abdominal symptoms without an identifiable cause. While the serotonergic system is thought to play a key role in the regulation of gut physiology, the role of the dopaminergic system, which is important in the regulation of visceral pain and stress, is under-studied. Therefore, this study investigated the dopaminergic system and its relationship with drinking capacity and symptoms in FD patients. In FD patients and healthy volunteers (HV) the dopaminergic system was investigated by in-vivo assessment of central dopamine D2 receptors (D2Rs) with [{sup 123}I]IBZM SPECT and by an acute, but reversible, dopamine depletion alpha-methyl-para-tyrosine (AMPT) challenge test. A nutrient drink test was performed to investigate the association between maximal ingested volume, evoked symptoms, and D2Rs. The HV subjects comprised 12 women and 8 men (mean age 31 {+-} 3 years), and the FD patients comprised 5 women and 3 men (mean age 39 {+-} 5 years). The FD patients had a lower left plus right average striatal binding potential (BP{sub NP}) for the caudate nucleus (p = 0.02), but not for putamen (p = 0.15), which in the FD patients was correlated with maximal ingested volume (r = 0.756, p = 0.03). The D2R BP{sub NP} in the putamen was correlated with nausea (r = 0.857, p = 0.01). The acute dopamine depletion test, however, failed to reveal differences in prolactin release between the FD patients and the HV subjects. These preliminary data suggest that chronic rather than acute alterations in the dopaminergic system may be involved in the pathogenesis of FD. Further studies are required to reproduce our novel findings and to evaluate to what extent the dopaminergic changes may be secondary to abnormalities in serotonergic pathways. (orig.)

  8. GASTROESOPHAGEAL REFLUX DISEASE IN PATIENTS WITH FUNCTIONAL DYSPEPSIA AND CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME: CLINICAL FEATURES AND EFFICACY OF LACTULOSE AND ITOPRIDE HYDROCHLORIDE

    Directory of Open Access Journals (Sweden)

    O. V. Krapivnaya

    2014-01-01

    Full Text Available Background: The frequent coexistence of gastroesophageal reflux disease (GERD with functional dyspepsia (FD and an irritable bowel syndrome (IBS has been described in the literature. Aim: To study the specific features of GERD clinical course and diagnosis in patients with GERD in combination with FD and constipation predominant IBS (IBS-C in comparison to patients with isolated GERD; to assess the efficacy of lactulose and itopride hydrochloride. Materials and methods: A total of 60 patients with GERD, FD (Rome criteria III, and IBS-C (Rome criteria III and 29 patients with isolated GERD were examined. GERD diagnosis was based on clinical, endoscopic, and pH-metric criteria. For 4 weeks 10 patients with combination of non-erosive reflux disease (NERD, FD and IBS-C received lactulose monotherapy and other 10 patients received combination of lactulose with itopride hydrochloride. Clinical symptoms and pH-metric parameters were assessed before and 4 weeks after treatment. Results: Combination of GERD, FD and IBS-C was noted more frequently in women under 40 with normal body mass index (р<0.05. Classic GERD symptoms were absent in 43.4% of patients with gastrointestinal comorbidity and in 10.3% of patients with isolated GERD (р=0.004. A higher prevalence of belching and nausea was found in patients, suffering from GERD, FD and IBS-C, than in those with isolated GERD (р<0.05. After 4-week lactulose and itopride hydrochloride treatment all the patients with GERD, FD and IBS-C showed a reduction of clinical symptoms (p<0.05 and normalization of pH-metric parameters (р<0.001. Conclusion: GERD course in patients with concomitant FD and IBS-C has the following peculiarities: predominance of women, absence of classic GERD-symptoms in almost half of these patients, and frequent combination with other functional symptoms. Combination therapy with lactulose and itopride hydrochloride enables successful control of GERD and FD symptoms as well as

  9. Genetic polymorphism of pri-microRNA 325, targeting SLC6A4 3'-UTR, is closely associated with the risk of functional dyspepsia in Japan.

    Science.gov (United States)

    Arisawa, Tomiyasu; Tahara, Tomomitsu; Fukuyama, Tomoki; Hayashi, Ranji; Matsunaga, Kazuhiro; Hayashi, Nobuhiko; Nakamura, Masakatsu; Toshikuni, Nobuyuki; Shiroeda, Hisakazu; Shibata, Tomoyuki

    2012-10-01

    The role of genetics in the susceptibility to functional dyspepsia (FD) remains unclear. We attempted to clarify the association between FD and polymorphisms in SLC6A4. In addition, rs5981521 (C>T) in the pri-microRNA 325 (pri-miR-325) coding region was also investigated. The study was performed in 395 subjects (172 with no upper abdominal symptoms and 223 with FD, including medication-resistant FD). We employed a polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) method to detect gene polymorphisms. Neither SLC6A4 -185 A>C nor *463 G>T was associated with susceptibility to FD. The number of rs5981521 T alleles was significantly correlated with an increased risk for FD (odds ratio [OR] 1.45, 95 % confidence interval [CI] 1.05-1.98; p = 0.022) and the TT homozygote was more closely associated with the risk for FD (OR 3.01, 95 % CI 1.41-6.42; p = 0.0043). The TT homozygote also had significantly increased risks for both the epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS) subtypes of FD (OR 3.04, 95 % CI 1.25-7.42; p = 0.014 and OR 3.05, 95 % CI 1.14-8.13; p = 0.026, respectively). In addition, Helicobacter pylori-negative TT homozygotes had a greater risk for FD (OR 8.37, 95 % CI 1.78-39.5; p = 0.0072). In subjects with the SLC6A4 5'-untranslated region (UTR) wild homozygote, the number of rs5981521 T alleles was significantly correlated to an increased risk for FD (OR 1.45, 95 % CI 1.03-2.04, p = 0.033). Of note, in subjects who were SLC6A4 3'-UTR mutant carriers, the number of rs5981521 T alleles was also significantly correlated with an increased risk for FD (OR 2.07, 95 % CI 1.08-3.98; p = 0.029). Our results suggest that the genetic polymorphism pri-miR-325 is associated with FD and interacts with SLC6A4 polymorphisms in increasing susceptibility to FD in Japanese.

  10. Meta-analysis of itopride therapy in functional dyspepsia%伊托必利治疗功能性消化不良的Meta分析

    Institute of Scientific and Technical Information of China (English)

    黄宣; 吕宾; 张烁; 范一宏; 孟立娜

    2012-01-01

    目的 根据现有的临床研究评价伊托必利治疗功能性消化不良(FD)的疗效与安全性.方法 检索Cochrane图书馆、EMBASE、PubMed、Elsevier、科学引文索引数据库、中国知网、维普、万方等数据库中有关伊托必利治疗FD的随机对照试验(RCT)文献,并提取纳入研究的特征信息,计数资料采用相对危险度(RR)值,计量资料采用加权均数差(WMD),根据异质性检验结果选择相应的效应模型,绘制漏斗图评定有无发表偏倚.结果 共有9项RCT符合纳入研究标准,2620例FD中有1372例接受伊托必利治疗,1248例接受安慰剂或其他药物对照治疗.伊托必利对FD患者的总体症状疗效、餐后饱胀疗效、早饱疗效的RR值分别为1.11(95%CI为1.01~1.21,P=0.02)、1.18(95%CI为1.04~1.33,P<0.01)、1.24(95%CI为1.01~1.53,P=0.04),均优于对照组,但在上腹不适疗效方面差异无统计学意义.Leeds消化不良问卷(LDQ)积分疗效的WMD值为-1.38(95%CI为-1.75~-1.01,P<0.01)伊托必利伏于对照组.在安全性方面,伊托必利与对照组不良反应发生率相似.各观察指标的漏斗图均基本呈现下宽上窄左右对称的图形,提示无发表偏倚.结论 伊托必利对于FD患者的总体症状、餐后饱胀、早饱、LDQ积分有较好的疗效,且不良反应发生率较低.%Objective To evaluate the efficacy and safety of itopride in the treatment of functional dyspepsia (FD) according to the data of published clinical studies.Methods The papers about randomized controlled trials (RCT) of itopride in treatment of FD were searched from Cochrane library,EMBASE,PubMed,Elsevier,web of science (ISI),China national knonledge internet (CNKI),VIP Chinese Scientific and Technologic Periodical Database and Wanfang data,and the feature information in the studies were extracted.The relative risk (RR) value was used for count data and the weighted mean difference (WMD) was used for measurement data.The proper

  11. 芜荑消积膏敷脐治疗小儿食积性腹泻的疗效观察%Clinical Study on Wuyi Xiaoji Plasters in Treating Infantile Diarrhea Due to Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    姚芳; 杨维华

    2012-01-01

    Objective:To observe the: effect of Wuyi Xiaoji Plasters (WYXJP ) in treating pediatrie dyspepsia diarrhea. Methods: A total of 120 eases infantile diarrhea due to dyspepsia were divided into 3groups,40 patients in treatment group I ,40 patients in treatment group 2,and 40 patients in control group. The treatment group I was given WYXTP by umbilical compression,the treatment group 2 was given Xiao Ru Da An Pill and WYXJP,and the control group was orally given Xiao Ru Da An Pill. Results: Clinical efficacy and healed rate in treatment group 2 were higher than in treatment group 1 (P < 0.05 ), significantly higher than the control group (P< 0. 01 ). Conclusion: Wuyi Xiaoji Plasters can obviously improve diarrhea symptoms of children with dyspepsia, and together with oral medicine could obviously improve curative effect. It is convenient and worth of clinical promotion.%目的:观察芜荑消积膏敷脐治疗小儿食积性腹泻的临床疗效.方法:将120例辨证为食积性腹泻的患儿随机分为治疗组1、治疗组2和对照组,每组各40例,治疗组1予以芜荑消积膏敷脐,治疗组2予以口服加减消乳大安丸配方颗粒并配合芜荑消积膏敷脐,对照组予以加减消乳大安丸配方颗粒口服.结果:临床疗效及治愈率治疗组2均优于治疗组1(P<0.05)、明显优于对照组(P<0.01).结论:芜荑消积膏敷脐能明显改善小儿食积性腹泻患儿的临床症状,与口服药配合使用可明显提高疗效,并且使用方便,值得临床推广.

  12. 依托比利联合黛力新治疗功能性消化不良的疗效观察%Based on Billy Combined with Deanxit Clinical Observation on the Treatment of Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    涂秀华

    2014-01-01

    目的观察依托比利联合黛力新治疗功能性消化不良(FD)的临床疗效。方法将2008年2月~2013年10月我院消化内科门诊确诊为FD患者104例随机分成两组,黛力新组:黛力新10.5mg Qd(早晨)、依托比利50mg Tid;对照组:依托比利50mg Tid,两组疗程均为4w。疗结束后观察症状消失并对疗效进行对比分析。结果治疗4w后餐后饱胀、早饱感、上腹痛、上腹烧灼感消失率,治疗组;87.93%,对照组54.34%(x2=14.72,<0.05))。结论依托比利联合黛力新治疗功能性消化不良疗效满意,是治疗功能性消化不良(FD)可供选择的方案。%Objective To evaluate Itopride combined with Deanxit in the treatment of functional dyspepsia (FD) clinical curative ef ect.Methods During 2008 February -2013 year in October my courtyard digestive outpatient department of internal medicine diagnosis for 104 patients with FD were randomly divided into two groups, Deanxit:Deanxit 10.5mg Qd (morning), Itopride 50mg Tid;Control group:Itopride 50mg Tid, the two groups were treated for 4 weeks. Observe the symptoms disappeared after treatment and to compare the ef ect .Results After 4 weeks treatment postprandial ful ness, early satiety, epigastric pain, epigastric burning sensation disappeared rate, the treatment group 87.93%, control group 54.34%, there was significant dif erence between 2 groups, (x2=14.72,<0.05)).Conclusion Itopride combined with Deanxit in the treatment of functional dyspepsia with satisfied ef ect, is the treatment of functional dyspepsia (FD) options.

  13. Treatment of functional dyspepsia with Changweishu capsule%肠胃舒胶囊治疗功能性消化不良51例疗效观察

    Institute of Scientific and Technical Information of China (English)

    祁永玲; 赵志娟

    2011-01-01

    目的 观察肠胃舒胶囊治疗功能性消化不良(FD)的临床疗效.方法 将102例FD患者随机分为2组.治疗组51例予肠胃舒胶囊治疗,对照组51例予枸橼酸莫沙必利片治疗,2组疗程均为4周.观察2组临床疗效和主要临床症状的改善情况.结果 治疗组总有效率96.08%,对照组总有效率82.35%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.治疗组主要症状上腹胀、上腹痛、厌食、早饱、嗳气、恶心和呕吐改善率均高于对照组(P<0.05).结论 肠胃舒胶囊对FD有良好的治疗作用,疗效优于西药枸橼酸莫沙必利片.%Objective To investigate the effect of functional dyspepsia treated with Changweishu capsule.Methods 102 patients with functional dyspepsia were randomly divided into two groups. Patients in treatment group(n =51 ) were treated by Changweishu capsule. Patients in control group were treated by Mosapride citrate tablets. The course was four weeks in two groups. The clinical effect and improvement of main clinical symptoms were observed.Results The total effective rate in treatment group(96.08% ) was higher than that in control group (82.35%, P <0.05). The improvement rate of key symptoms of bloating, abdominal pain, anorexia, early satiety, belching, nausea and vomiting in treatment group were higher than those in control group( P < 0.05). Conclusion Changweishu capsule has a good effect on functional dyspepsia, the effect was more than that of Mosapride citrate tablets.

  14. 疏肝和胃法治疗功能性消化不良的临床疗效观察%Clinical observation on functional dyspepsia treated by Shugan Hewei method

    Institute of Scientific and Technical Information of China (English)

    来要水; 陈彬; 易灿辉

    2012-01-01

    [Objective] To explore the effect of Shugan Hewei in the treatment of functional dyspepsia. [Methods] Sixty patients with functional dyspepsia were randomly divided into the treatment group (n=30) and the control group (n=30). The treatment group was given with Shugan Hewei, and the control group was given with Domperidone only for 4 weeks. The improvement of clinical symptoms, such as early satiety, upper abdominal pain, stomach burn, abdominal distention and eructation, were evaluated by clinical symptom score. [Results] After treatment, the improvement of abdominal symptom score of control group was significantly lower than that of trestment group (P<0.05). [Conclusion] Shugan Hewei is more effective in treating patients with functional dyspepsia than Domperidone. It deserves clinical expansion.%[目的]观察中药疏肝和胃法治疗肝胃不和型功能性消化不良(FD)的疗效.[方法]采用随机、对照的观察方法,将60例患者分为对照组和治疗组,治疗组采用疏肝和胃法,对照组采用吗丁啉治疗.经过4周治疗,采用临床症状积分法,观察功能性消化不良的上腹饱胀、两胁胀痛、早饱、暖气、心烦易怒等症状缓解情况.[结果]经过治疗后,中药疏肝和胃法可以明显改善上腹饱胀、早饱感、上腹疼痛、厌食症状积分,其总疗效优于对照组(P<0.05).[结论]以疏肝和胃法对FD的临床单项症状评分及临床总有效率均明显高于吗丁啉对照组,有一定的疗效.

  15. 小剂量地西泮联合莫沙比利治疗功能性消化不良效果分析%Effect Analysis on Functional Dyspepsia Patients by Small Doses of Diazepam Combined with Mosapride

    Institute of Scientific and Technical Information of China (English)

    赵彩云

    2015-01-01

    Objective To investigate the application value evaluation for functional dyspepsia patients by small doses of diazepam combined with mosapride. Methods One hundred and seventy-two functional dyspepsia patients who were treated in the depart-ment of gastroenterology of the hospital of traditional Chinese medicine in jiashan county of jiaxing city in zhejiang province hospi-tal from April 2010 to April 2012 were divided into the control group and the observation group by random number table. The control group were only given mosapride,the observation group were given small doses of diazepam combined with mosapride. Then clinical efficacy and adverse reactions rate were compared. Results The total efficiency rate of the observation group were statisti-cally higher than that of the control group (95.35%vs86.05%,P0.05). Conclusion The clinical efficacy of functional dyspepsia patients by small doses of diazepam combined with mosapride is sure,it is superior to mosapride alone,it has the characteristics of safe and reliable and less adverse reactions.%目的:探究功能性消化不良患者运用小剂量地西泮联合莫沙必利治疗的临床效果。方法应用随机数字表法将该院消化科2012年6月—2014年6月间治疗的172例功能性消化不良患者分为对照组和观察组,对照组给予口服莫沙必利进行治疗,观察组在此基础上给予小剂量地西泮进行治疗,比较两组患者的临床治疗效果和不良反应的发应率。结果观察组的临床治疗效果明显优于对照组,差异有统计学意义(95.35%vs86.05%,P0.05)。结论对于消化性功能不良患者运用小剂量地西泮联合莫沙必利进行治疗的临床效果较为显著,优于单用莫沙必利治疗者,具有安全高效和不良反应少等特点。

  16. 健脾行气法治疗功能性消化不良临床观察%Clinical Observation of Using Spleen Invigorating and Qi Promoting Method to Treat Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    张庆; 梁超

    2011-01-01

    Objective: To observe the clinical curative effect using spleen invorating and Promoting Qi method to threat functional dyspepsia, and approach the superiority in the Traditional Chinese Medicine to treat chronic appetite systemic disease.Methods: To utilize the method of invigorating spleen and promoting Qi to differentiate symptoms and signs and add or to decrease according of clinical symptom to treat thirty examples of the type of splenic asthenia and gas-sluggish of functional dyspepsia, and thirty examples of control group. The treatment group was given prescription according to the method of invigorating spleen and Qi promoting to add or to decrease; the control group was treated by means of domperidone. The average course of treatment was four weeks. Contrasting the index of two sets, such as the total effective rate, total accumulated points of symptom, the improve of major clinical symptom and so on, as well as to make out the judgement. Results: The total effective rate of curity group was 90%, and the control group was 67.9%, there was significant difference between the two groups, P<0. 05,to hint that the total curative effect of curity group surpass the control group to use the method of invigorate spleen and invigorating spleen and promoting Qi to cure the type of splenic asthenia and gas sluggish of functional cyspepsia. Conclusion: The curative effect is indeed that according to the method of respiration technique and respiration technique to treat the type of splenic asthenia and gas sluggish of functional dyspepsia, and it also is one of effective method to treat functional dyspepsia.%目的:观察健脾行气法治疗脾虚气滞型功能性消化不良的临床疗效,并探讨中医药在治疗慢性脾胃系统疾病中的优势.方法:将确诊为脾虚气滞型功能性消化不良患者58例随机分为治疗组30例,对照组28例.治疗组予以根据健脾行气法拟定的运脾行气汤加减治疗;对照组予以多

  17. Dispepsia funcional: Nuevos conocimientos en la fisiopatogenia con implicaciones terapéuticas Functional dyspepsia: New pathophysiologic knowledge with therapeutic implications

    Directory of Open Access Journals (Sweden)

    Ana C. Hernando-Harder

    2007-08-01

    Full Text Available La dispepsia funcional (DF es un complejo sintomático, heterogéneo y altamente prevalente en la comunidad y en la práctica general. La DF se define como la presencia de síntomas que se piensan originados en la región gastroduodenal, en ausencia de enfermedad orgánica, sistémica o metabólica que pueda explicarlos. Entre los factores fisiopatogénicos se incluyen los trastornos de la acomodación y del vaciamiento gástrico, dismotilidad duodenal, sensibilidad aumentada, factores psicosociales y una asociación con un estado postinfeccioso. Se han hecho numerosos esfuerzos para aumentar los conocimientos en la etiopatogenia del síndrome, incluyendo nuevos aspectos moleculares y genéticos. Sin embargo, el mecanismo etiopatogénico exacto que causa los síntomas en un paciente individual sigue siendo difícil de identificar. Los nuevos criterios de Roma III redefinen y subclasifican la DF basándose en sus síntomas principales, lo cual es de gran valor para la investigación, el desarrollo y el control estandarizados de nuevas estrategias terapéuticas así como la formulación de recomendaciones para la práctica clínica. Las modalidades terapéuticas que se han empleado incluyen: modificaciones dietéticas, agentes farmacológicos dirigidos a actuar sobre distintos blancos dentro del aparato gastrointestinal, del sistema nervioso central y periférico, y terapias psicológicas incluyendo la hipnoterapia. Desafortunadamente, hasta la fecha, todas estas terapias han rendido solamente resultados marginales. Después de excluir enfermedad orgánica, es esencial que el paciente esté informado sobre la naturaleza y el pronóstico benignos de su enfermedad, y esto puede ser, a veces, la inversión más provechosa tanto para el paciente como para su médico.Functional dyspepsia (FD is a heterogeneous, highly prevalent symptom complex in the community and general practice. FD is defined as the presence of symptoms considered as originated in

  18. Dyspepsia in chronic psychiatric patients

    NARCIS (Netherlands)

    Mookhoek, E.J.; Meijs, V.M.M.; Loonen, A.J.M.; Leufkens, H.G.M.

    2005-01-01

    Introduction: We report on dyspeptic complaints among patients hospitalized in the long-stay ward of a general psychiatric hospital. Methods: A representative sample of the patients was interviewed using a structured questionnaire. Results: Eighty percent of the patients reported one or more symptom

  19. Investigation of functional dyspepsia among soldiers participated in military maneuver%参加军事演习官兵功能性消化不良发病情况的调查

    Institute of Scientific and Technical Information of China (English)

    赵毅; 陈海花; 朱玲玲; 韩富建

    2012-01-01

    目的 调查了解某部参加演习官兵功能性消化不良(FD)的发生率及其影响因素.方法 采用整群抽样的方法,应用焦虑自评量表(SAS)、抑郁自评量表(SDS)和功能性胃肠病罗马(Rome)Ⅲ的诊断标准中的症状自评量表,对参加演习的1000名官兵进行问卷调查.结果 FD发生率为19.7%,其中焦虑者76.26%、抑郁者86.96%,高于非FD者,差异具有显著性统计学意义(FD与非FD官兵SAS得分x2=5.2157,FD与非FD官兵SDS得分x2=5.472 8,P<0.01);FD患者参加训练压力大,并不能耐受,与非FD者比较,差异有显著统计学意义(x2=349.4804,P<0.01);FD患者完成作训任务难度大,与非FD者比较,差异有显著统计学意义(x2=4.5367,P<0.01);症状居首位的是腹部不适(53.81%).结论 参加演习官兵FD发生率较高,与训练紧张引起焦虑、抑郁有关,应根据不同时期、不同环境和条件,进行科学的心理疏导,保持其健康水平.%Objective To investigate the incidence of functional dyspepsia (FD) and the factors related to FD in a population participated in military maneuver.Methods We made a questionnaire survey in 1000soldiers who participated in military maneuver using a cluster sampling method,self-rating anxiety scale( SAS),self-rating depressive scale(SDS) and self-rating functional dyspepsia scale.Results The total incidence rate of functional dyspepsia was up to 19.7%,within which 76.26% with anxiety and 86.96% with depression,which was significantly higher than non-FD soldiers with statistically significant difference (SAS in FD and non-FD:x2 =5.215 7,SDS in FD and non-FD:x2 =5.472 8,both P <0.01).FD soldiers were more difficult to accomplish training task compared with non-FD soldiers with statistically significant difference ( x2 =4.536 7,P<0.01).The most frequent symptom of FD was abdominal discomfort (53.81%).Conclusions The relatively higher incidence of FD in the soldiers who participate in military maneuver is

  20. Experience in the Treatment of Functional Dyspepsia with Xinkai Kujiang Method%辛开苦降法综合治疗功能性消化不良经验

    Institute of Scientific and Technical Information of China (English)

    李依洁; 魏玮; 杨俭勤

    2015-01-01

    Functional dyspepsia is the common functional gastrointestinal disease in clinic,manifes-ted as upper gastric pain and distention,burning sensation in the upper gastric region,gastric fullness in the morning and belching. This disease has a long duration of sickness,apparent symptoms,difficulty in diagnosis and high treatment cost and recurrence rate,and has a high comorbidity of mental disorder as well. All of these induce tremendous influence on the life quality of patient. This disease is mainly differentiated as five patterns,named mixture cold and heat,liver qi stagnation,liver stagnation and spleen deficiency,damp heat in spleen and stomach and food accumulation. Prof. Wei Wei has been engaged in clinical practice for over 30 years in the treatment of various internal diseases with classical formulas on the basis of syndrome differentia-tion and has accumulated rich experiences in the treatment of functional dyspepsia. Prof. Wei believes that functional dyspepsia is chiefly differentiated as mixture of cold and heat,and treated with banxia xiexin tang or xiaopi tongjiang tang to regulate cold and heat. Based on the idea of“preventive treatment of disease”,the ther-apeutic thinking is innovated,the pathogenesis is refined and the modified medication is greatly considered so as to improve patientˊs body constitution and the curative rate of the disease and reduce recurrence rate.%功能性消化不良为临床常见的功能性胃肠病,以上腹疼痛胀满、上腹烧灼感、早饱感、嗳气为主要表现。该病病程较长、症状明显、诊断困难、治疗成本和复发率高,同时与精神障碍存在比较高的共病率,对患者生活质量影响巨大。该病辨证主要分为寒热错杂证、肝郁气滞证、肝郁脾虚证、脾胃湿热证和饮食积滞证五型。魏玮教授临证三十余载,运用经方辨证施治内科诸症,积累了治疗功能性消化不良的丰富经验,认为该病以寒热错杂证为

  1. The Correlation between Functional Dyspepsia and Psychological and the Application Effect of Antidepressants%功能性消化不良与心理因素的相关性及抗抑郁药的应用效果

    Institute of Scientific and Technical Information of China (English)

    冯燕

    2015-01-01

    Objective:To analyze correlation between functional dyspepsia and psychological and the application effect of antidepressants. Method:30 patients with functional dyspepsia during 2014 in our hospital were selected,they were average divided into the control group and the observation group,the control group was taken conventional treatment,the observation group used was taken conventional treatment,antidepressant treatment and psychological nursing intervention.The clinical therapeutic effects of two groups were analyzed.Result:The clinical treatment efficiency of the observation group and control group were 93.33%,60.00%,there was statistical significance(P<0.05).The scores of gastrointestinal symptoms in the observation group and the control group before and after treatment had statistical significance(P<0.05),SCL-90 score of the observation group before and after treatment had statistical significance(P<0.05).The incidence of adverse reactions in the observation group and the control group were 13.33%,46.67%,there was statistical significance(P<0.05).Correlation analysis of indigestion and psychological factors had the correlation(r=0.549, P=0.0000<0.05).Conclusion:Functional dyspepsia patients have different degrees of anxiety,depression,psychological nursing intervention,and antidepressant drugs adjuvant therapy can improve the patient's clinical symptoms,the quality of life,improve the effect of clinical treatment,so it can be for popularization and application.%目的:分析功能性消化不良与心理因素的相关性以及抗抑郁药的应用效果。方法:选择2014年笔者所在医院收治的30例功能性消化不良患者,将其平均分为对照组和观察组,对照组使用常规治疗,观察组使用常规治疗+心理护理干预+抗抑郁药物治疗。针对两组患者的临床治疗效果进行分析研究。结果:观察组与对照组患者的临床治疗有效率分别为93.33%、60.00%,差异有统计学意义(P<0.05)

  2. Trazodone Combined Psychological Counseling for Treating 50 Cases of Functional Dyspepsia%曲唑酮联合心理疏导治疗功能性消化不良50例

    Institute of Scientific and Technical Information of China (English)

    李广红; 季淑梅

    2011-01-01

    目的 观察曲唑酮联合心理疏导治疗功能性消化不良的疗效.方法 将100例确诊为功能性消化不良的患者分为心理治疗组和对照组各50例,两组均给予雷尼替丁胶囊1粒、1日2次,多潘立酮片10mg、1日3次,均饭前口服.心理治疗组加用心理疏导和曲唑酮50mg,1日2次,早、晚饭后口服,疗程4周.结果 心理治疗组与对照组治疗1,2,4周后总有效率分别为68.33%,85.00%,95.00%和41.67%,51.67%,58.33%,两组疗效差异非常显著(P<0.01).治疗4周后心理治疗组上腹胀痛、上腹烧灼和上腹不适、早饱、嗳气等症状改善积分总有效率分别为94%,93%,93%,明显高于对照组的56%,56%,55%(P<0.01).结论 心理疏导和抗抑郁药对伴有焦虑和抑郁症状的功能性消化不良患者治疗效果十分显著,值得临床医师重视和推广.%Objective To evaluate the effect of trazorlone combined psychological counseling in the treatment of functional dyspepsia. Methods A hundred patients diagnosed functional dyspepsia were divided into the psychological treatment group and the control group, 50 cases in each group. Two groups were given Ranitidine Capsule, twice daily, domperidone lOmg, 3 times daily, all orally taking: before meals. The psychological treatment group was added the psychological counseling and trazodone 50 mg, twice daily, all hy orally taking after breakfast and supper, with the treatment course of 4 weeks. Results The total effective rates after 1, 2, 4 weeks of treatment were 68. 33%, 85. 00% and 95.00% in the psychological treatment group and 41. 67% , 52. 00% and 58.33% in the control group, showing very significant difference between them( P < 0. 01 ). The total effective rates in the symptomatic improvement scores of epigastric pain, epigastric burning sensation and epigastric discomfort, early satiety and belching after 4 - week treatment were 94%, 93% and 93% in the psychological treatment group, which were significantly higher than 56

  3. 功能性消化不良与精神心理因素的相关性及中药的干预作用%Advances in understanding the relationship between functional dyspepsia and mental factors

    Institute of Scientific and Technical Information of China (English)

    李勇; 贺丹军; 魏睦新

    2012-01-01

    功能性消化不良(functional dyspepsia,FD)与精神障碍的共病率达42%-61%.精神心理因素与FD相互作用的机制与脑-肠轴的调节障碍有关,主要包括中枢神经系统刺激-处理过程异常和脑-肠肽异常.脑影像学研究发现FD患者内脏高敏感与中枢内脏感觉处理功能异常有关,胃肠道疼痛刺激可引起脑部眶侧额叶皮质、扣带回前部、岛叶、背侧丘脑、杏仁核等区域异常激活.中枢5-羟色胺能抗抑郁药物治疗FD有一定疗效.中医学认为反复、持久的情志刺激能影响肝的疏泄,进而影响脾胃纳化功能,导致FD发生,理气药、芳香化湿药、补益药、活血化瘀药等对胃肠动力有不同程度调节作用.%The co-morbidity of functional dyspepsia (FD) and mental disorders is 42%-61%. Growing evidence shows that visceral hypersensitivity and abnormality of brain gut peptides are possibly responsible for the interactions between FD and mental disorders, and the brain-intestine axis plays a crucial role in the development of visceral pain. Functional magnetic resonance imaging is a novel and effective tool for studying visceral hypersensitivity. Gastric pain activates a wide range of cortical and subcortical structures, including the cortex of frontal lobe, anterior cin- gulate cortices, insula, thalamus and amygdala. Several studies show that selected serotonergic antidepressants and some traditional Chinese medicine can improve the symptoms, especially pain, of FD; however, the underlying mechanisms remain unclear.

  4. 从病理学角度谈慢性胃炎与功能性消化不良的诊断与治疗%Differential diagnosis and therapy between functional dyspepsia and chronic gastritis with pathology

    Institute of Scientific and Technical Information of China (English)

    朱薇; 张亚历

    2013-01-01

    It is easy to confuse chronic gastritis and functional dyspepsia (FD) in clinical practice. In theory, chronic gastritis is an organic disease, which shows gastric mucosal erosions or atrophy lesions on endoscopic and active inflammation whose symbol is neutrophil infiltration and glandular epithelium damage on biopsy. Also, when it is atrophic gastritis , it manifests as the reduction of the glands, intestinal metaplasia, dyspepsia and so on. Although, on endoscopic, FD can be diagnosed as chronic superficial gastritis, there are no significant gastric mucosal erosion or atrophy lesions. On the other hand, there may be infiltration of lymphocytes on biopsy, but no active inflammation and glandular epithelial lesions. It' s important to master the differences of the two diseases on the etiology, diagnosis and treatment for standardizing the diagnosis and treatment of chronic gastritis and FD.%慢性胃炎与FD临床上两者容易造成混淆,理论上,慢性胃炎属于器质性病变,内镜下胃黏膜有糜烂或萎缩病变,病理活检表现为活动性炎症,以中性粒细胞浸润和腺上皮损害为标志;萎缩性胃炎则表现为固有腺体的减少、肠上皮化生和异型增生等.FD内镜虽也可诊断为慢性浅表性胃炎,但胃黏膜并无明显糜烂或萎缩病变;病理活检可出现淋巴细胞浸润,但并无活动性炎症和腺上皮病变等特征.掌握两种疾病在病因、诊断和治疗上的不同特点,对规范慢性胃炎和FD的诊治有重要意义.

  5. Impact of functional dyspepsia on quality of life in eating disorder patients: the role of thought-shape fusion Impacto de la dispepsia funcional sobre la calidad de vida en los trastornos de la conducta alimentaria: papel de la fusión pensamiento-forma

    Directory of Open Access Journals (Sweden)

    I. Jáuregui Lobera

    2011-12-01

    Full Text Available Objective: The study begins by analysing the psychometric properties of the Nepean Dyspepsia Index-Short Form (NDI-SF, before moving on to study quality of life in patients with functional dyspepsia (FD and the psychopathological features that underlie the disorder in three groups of subjects: patients with eating disorders (ED, psychiatric patients (non-ED, and a group of students, all of whom fulfilled Rome III criteria for FD. The analysis specifically focused on the relationship between thought-shape fusion (TSF and functional dyspepsia, and hence on the potential repercussions this could have on the quality of life of patients with eating disorders. Methods: The sample comprised 78 ED outpatients, 77 non-ED outpatients, and 90 university students, all of them with associated FD (Rome III criteria. The mental disorders (ED and non-ED fulfilled the diagnostic criteria of DSM IV-RT. In all cases, the symptoms of dyspepsia, the related quality of life, anxiety, depression, and TSF were determined. Results: Satiation and bloating were significantly higher in ED patients. Correlations between dyspepsia and TSF were initially positive and significant in all cases, but significance was only maintained in the group of ED patients after controlling for the other psychopathological variables. Regarding the ED group, the regression analysis revealed the following predictors of quality of life: dyspepsia, depressive symptomatology, TSF-conceptual, TSF-interpretative and total TSF. Discussion: The cognitive distortion of TSF appears to constitute a general bias common to all eating disorders, with specific effect on the characteristic symptoms of FD.Objetivo: se analizaron las propiedades psicométricas del Nepean Dyspepsia Índex-Short Form (NDI-SF, previo al estudio de la calidad de vida en pacientes con dispepsia funcional (DF y variables psicopatológicas subyacentes a dicho trastorno en pacientes con trastornos de la conducta alimentaria (TCA

  6. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study.

    Science.gov (United States)

    Koloski, N A; Jones, M; Talley, N J

    2016-09-01

    Traditionally, functional gastrointestinal disorders (FGIDs) are conceptualised as originating in the brain via stress pathways (brain-to-gut). It is uncertain how many with irritable bowel syndrome (IBS) and functional dyspepsia (FD) have a gut origin of symptoms (gut-to-brain pathway). To determine if there is a distinct brain-to-gut FGID (where psychological symptoms begin first) and separately a distinct gut-to-brain FGID (where gut symptoms start first). A prospective random population sample from Newcastle, Australia who responded to a validated survey in 2012 and completed a 1-year follow-up survey (n = 1900). The surveys contained questions on Rome III IBS and FD and the Hospital Anxiety and Depression Scale. We found that higher levels of anxiety and depression at baseline were significant predictors of developing IBS (OR = 1.31; 95% CI 1.06-1.61, P = 0.01; OR = 1.54; 95% CI 1.29-1.83, P intestinal features in many cases. © 2016 John Wiley & Sons Ltd.

  7. 肝硬化患者消化不良症状机制的研究进展%Research Progress in Mechanism of Dyspepsia Symptoms of Patients with Liver Cirrhosis

    Institute of Scientific and Technical Information of China (English)

    谢智慧; 徐永红; 杨立廷

    2013-01-01

    Liver cirrhosis is a phase of chronic hepatopathy, and 80% of liver cirrhosis patients have dyspepsia symptoms,such as loss of appetite, satiety, belching, sour regurgitation, nausea, vomit, abdominal pain,etc.. To date,the mechanism remains unclear. It may be connected with Hp infection,gut dismotility, hormone disturbance,autonomic system dysfunctions,alteration of intestina flora,endotoxemia and psychological factors.%肝硬化是慢性肝病进程中的一个发展阶段,80%肝硬化患者可出现食欲缺乏、早饱、嗳气、反酸、恶心、呕吐、腹痛等一种或多种临床综合征,其发生机制尚不明确,可能与幽门螺杆菌(Hp)感染、胃肠动力障碍、胃肠激素紊乱、自主神经功能紊乱、肠道菌群失调和内毒素血症、精神心理因素有关.

  8. Expression and Significance of Duodenal Eosinophils in Patients with Functional Dyspepsia%功能性消化不良患者十二指肠嗜酸性细胞表达及其意义

    Institute of Scientific and Technical Information of China (English)

    张思寒; 王承党

    2015-01-01

    Functional dyspepsia( FD)is a group of clinical syndromes presented as upper abdominal pain,epigastric burning sensation,postprandial fullness,satiety and other symptoms,but lack of organic disease causing these symptoms. Eosinophils( EOS)in gastrointestinal tract play an important role in preventing pathogen invasion and maintaining intestinal epithelial homeostasis. In recent years,many studies have shown a significant increase of duodenal EOS in patients with FD. This article reviewed the expression and significance of duodenal EOS in patients with FD.%功能性消化不良( FD)是指具有上腹痛、上腹灼热感、餐后饱胀、早饱等不适症状,但缺乏引起上述症状的器质性疾病的一组临床综合征。胃肠道嗜酸性细胞( EOS)在抵抗病原体入侵、维持肠上皮细胞稳态等方面发挥重要作用。近年研究表明FD患者十二指肠EOS增多,本文就FD患者十二指肠EOS表达及其意义作一综述。

  9. The investigation of water load test for the evaluation of functional dyspepsia%关于水负荷试验对功能性消化不良评价的调查

    Institute of Scientific and Technical Information of China (English)

    李哲; 陶琳; 肖旸

    2013-01-01

    目的 分析水负荷试验(water load test,WLT)结果 与功能性消化不良(functional dyspepsia,FD)患者性别、年龄、体质量、亚型和心理评分的相关性.方法 纳入330例FD患者,记录人口学特征,以WLT测定受试者的阈值饮水量(threshold volume,TV) 和饱足饮水量(satiety volume,SV),以汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)和抑郁量表(Hamilton depression scale,HAMD)评价心理状况.结果 男性的TV、SV均显著高于女性(P0.05).结论 WLT评价FD患者胃感觉功能的结果 受性别影响,可能和心理因素有关,与亚型、年龄、体质量无关.WLT是一项比较稳定和可靠的评价FD的检查方法.

  10. 莫沙必利与氟西汀联用治疗功能性消化不良的疗效分析%Analysis on the clinical effect of mosapride combined with fluoxetine for the treatment of functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    舒涛

    2013-01-01

    目的分析联合应用氟西汀与莫沙必利治疗功能性消化不良的临床效果。方法将2012年11月-2013年6月我院143例功能性消化不良患者随机分为观察组(氟西汀与莫沙必利联合用药组)72例及观察组(莫沙必利单用组)71例,比较两组效果。结果观察组显效率明显高于对照组,不良反应发生率与对照组无统计学差异。结论氟西汀应用到功能性消化不良能明显提高疗效,同时不良反应发生率未明显增加。%Objective To analyse the clinical effect of mosapride combined with fluoxetine for the treatment of functional dyspepsia and provide some help for clinical treatment. Methods From November 2012 to June 2013, we selected 143 patients with functional dyspepsia as the objects in our hospital. They were randomly divided into observation group(mosapride combined with fluoxetine group, n=72) and control group(simplex mosapride group, n=71). We made a comparison on the clinical effect of two methods. Results In observation group, the efficiency was markedly higher than the control group, the adverse reactions rate was not significant when compared with the control group. Conclusion The fluoxetine for the treatment of functional dyspepsia can significantly improve treatment effect. The incidence of side effects was not elevated markedly.

  11. Clinical observation of Jian Wei Xiao Shi oral liquid on functional dyspepsia in children%健胃消食口服液治疗小儿功能性消化不良的临床观察

    Institute of Scientific and Technical Information of China (English)

    万俊; 包志丹; 王向烨; 李虎

    2012-01-01

    目的 观察健胃消食口服液对小儿功能性消化不良的临床疗效.方法 将106例功能性消化不良患儿随机分为Ⅰ组50例,Ⅱ组56例.2组患儿均于餐前服用多潘立酮混悬剂;Ⅰ组患儿在此基础上加用健胃消食口服液.2周为1个疗程.观察2组患儿临床疗效,比较食欲减退、食量减少、嗳气腹胀、恶心呕吐、大便稀薄等症状改善的时间以及总疗程的差异.结果 Ⅰ组临床总有效率明显高于Ⅱ组,差异有统计学意义(P<0.01);Ⅰ组患儿食欲减退、食量减少、嗳气腹胀、恶心呕吐、大便稀薄等症状改善的时间以及总疗程均明显短于Ⅱ组,差异有统计学意义(P<0.01).结论 健胃消食口服液联合多潘立酮混悬剂治疗小儿功能性消化不良可明显缩短症状改善时间,提高了临床疗效.%Objective To observe the clinical effect of Jian Wei Xiao Shi oral liquid on functional dyspepsia in children. Methods 106 cases with functional dyspepsia were randomly divided into group Ⅰ(n - 50) and group Ⅱ (n = 56). The two groups received domperidone suspension before meals, and the patients in group I were given extra Jian Wei Xiao Shi oral liquid. One treatment session lasted for two weeks. The clinical effect was observed. The differences of improvement time of anorexia, reduction of appetite and food intake, belching and abdominal distension, nausea and vomiting, watery stool and total course between the two groups were compared. Results The clinical efficacy rate of group Ⅰ was higher than that of group Ⅱ (P<0.01). The improvement time of anorexia, reduction of appetite, belching and abdominal distension, nausea and vomiting, watery stool and total course of group I were obviously shorter than those of group Ⅱ (P < 0.01). Conclusion Jian Wei Xiao Shi oral liquid combined with domperidone suspension can obviously shorten time for symptom improvement and enhance the clinical effect.

  12. 功能性消化不良合并抑郁症的危险因素分析%Risk factors of depression in patients with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    刘丽妮; 樊华; 刘斌

    2015-01-01

    Objective To explore the risk factors of depression in patients with functional dyspepsia.Methods From July 2014 to September 2014, a total of 295 patients was diagnosed of functional dyspepsia (FD).All of them were evaluated with the 17-item Hamilton Depression Rating Scale (HAMD-17).They were divided into two groups: FD with depression and FD without depression.Socio-demographic and clinical features were collected and analyzed.Logistic regression analysis was used to detect risk factors of depression in FD patients.Results In our studies, 20.0% (59/295) of FD patients were diagnosed as depression.Risk factors for depression were age, disease duration, and marriage in univariate analysis, and marriage and disease duration in multivariate analysis.FD patients with moderate to severe depression had a longer duration of disease and more sessions of gastroscopy than those with mild depression.Conclusions Prevalence of depression is higher in FD patients with incomplete marriage and long disease duration, routine depression screening should be carried out for these patients.%目的 探讨功能性消化不良(FD)患者合并抑郁症的临床特点及相关危险因素.方法 对2014年6月至2014年9月诊断为功能性消化不良的295例患者进行汉密尔顿抑郁量表评定,根据结果分为功能性消化不良伴抑郁症组和功能性消化不良不伴抑郁症组,对两组患者的社会人口学资料和临床资料进行分析,采用Logistic回归分析探讨功能性消化不良并发抑郁症的危险因素.结果 功能性消化不良患者中抑郁症的发病率为20.0% (59/295),单因素分析显示年龄、居住地、病程、婚姻状况是功能性消化不良合并抑郁症的危险因素(P<0.05);多因素分析显示婚姻状况、病程为FD并发抑郁症的危险因素(P<0.05).合并中、重度抑郁症的FD患者比合并轻度抑郁症的患者病程更长、接受胃镜检查的次数更多(P<0.05).结论 婚姻不完整

  13. Influence of Fructus Aurantii Immaturus Flavonoids on Gastrointestinal Motility in Rats with Functional Dyspepsia%枳实黄酮对功能性消化不良大鼠胃肠动力的影响

    Institute of Scientific and Technical Information of China (English)

    黄爱华; 迟玉广; 曾元儿; 卢丽萍

    2012-01-01

    目的 探讨枳实黄酮类成分对功能性消化不良大鼠胃肠动力的影响及其可能机制.方法 健康成年Wistar大鼠60只,随机分为正常对照组、模型组、多潘立酮组、橙皮苷组、新橙皮苷组、柚皮苷组.测定各组大鼠胃排空速率、小肠推进比,采用酶联免疫分析方法测定胃动素(MTL)及血管活性肠肽(VIp).结果 模型组大鼠胃排空率与小肠推进比明显低于正常对照组(P<0.05,P<0.01);应用枳实黄酮各组后,大鼠胃排空率与小肠推进比增加,与正常对照组和多潘立酮组比较,差异无统计学意义(P>0.05).模型组大鼠MTL明显低于正常对照组(P< 0.05),VIP明显高于正常对照组(P<0.05).应用橙皮苷后胃动素明显增加,与正常对照组和多潘立酮组比较,差异无统计学意义(P>0.05).结论 枳实黄酮可改善功能性消化不良大鼠的胃排空和小肠推进,其中橙皮苷对胃动力的作用可能与其增加MTL有关.%Objective To investigate the effect of flavonoids in Fructus Aurantii Immaturus on gastrointestinal motility in rats with functional dyspepsia and to explore its possible mechanism. Methods A total of 60 adult wistar rats were randomly divided into six groups, normal control group, model control group, domperidone group, hesperidin group, neohesperidin group, and naringin group. After treatment, serum motilin(MTL) and vasoactive intestinal peptide(VIP) levels were measured by ELISA, gastric emptying rate and small intestinal propulsion rate were examined. Results Compared with the normal control group, the gastric emptying rate and small intestinal propulsion rate in the model group were markedly decreased(P 0.05). MTL level was decreased significantly (P 0.05). Conclusion The flavonoids in Fructus Aurantii Immaturus can promote gastrointestinal motility in rats with functional dyspepsia, and hesperidin can improve MTL level.

  14. TO STUDY MENTAL HEALTH OF PATIENTS WITh FUNCTIONAL DYSPEPSIA AND ITS NURSING METHODS%功能性消化不良患者心理健康研究及对策

    Institute of Scientific and Technical Information of China (English)

    夏传红

    2009-01-01

    目的 分析功能性消化不良(FD)患者的心理健康状态,并提出护理对策.方法 采用临床症状自评量表(SCL-90)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)分别对研究组24例FD患者和对照组24例健康人进行测评,比较其评分差异.结果 研究组与对照组三种量表(HAMA、HAMD、SCL-90)评分比较,均存在显著性差异(P<0.01).结论 FD患者心理健康(包括心理和躯体两方面)状态较差,应对其进行积极地干预和心理护理.%Objective To explore the state of mental health of patients with functional dyspepsia(FD) and the corresponding nursing measures.Methods The mental state of 24 FD patients and 24 healthy persons were surveyed by using Hamilton Depression(HAMD),Hamilton anxiety(HAMA) and SCL-90 scales and the results were compared.Results According to HAMA,the scores of mental and physical factors were higher in the research group than in the contrast group(P<0.01).According to HAMD,There existed significant differences between the two groups except in terms of changes of factors in day and night and the sense of depression(P<0.01).The SCL-90Assessment revealed that all factors but psychopathological factor were higher in the research group than in the contrast group(P<0.01).ConclusionFD patients should be given active intervention and mental nursing for their poor mental and physical states.

  15. The investigation and analysis on mental health condition of functional dyspepsia patients%功能性消化不良患者的心理健康状况调查

    Institute of Scientific and Technical Information of China (English)

    孙年霞

    2013-01-01

    目的 探讨功能性消化不良(FD)患者的心理健康状况.方法 按照就诊时间选取某门诊2011年1~12月期间就诊的120例FD患者作为调查研究对象(FD组),及同期门诊体检正常者100例作为对照组,进行艾森克人格测试量表(EPQ)、症状自评量表(SCL-90)、焦虑自评量表(SAS)、抑郁自评量表(SDS)调查问卷测评.结果 (1) EPQ:E、N、P、L4个维度对照组评分分别为(50.48±8.21)分、(53.42±9.02)分、(51.33±10.46)分、(52.89±8.11)分,FD组为(54.24±9.32)分、(48.95±8.26)分、(48.74±7.39)分、(55.64±8.70)分,比较差异有统计学意义(P<0.05). (2) SCL-90:躯体化、强迫、抑郁、焦虑、敌对性因子评分对照组分别为(1.37±0.47)分、(1.62±0.43)分、(1.51±0.61)分、(1.40±0.57)分、(1.48±0.55)分,FD组分别为(1.52±0.82)分、(1.79±0.68)分、(1.69±0.64)分、(1.61±0.68)分、(1.66±0.59)分,比较差异有统计学意义(P<0.05),人际关系、恐怖、偏执、神经病性因子评分两组差异无统计学意义(P>0.05). (3) SAS、SDS:对照组分别为(43.41±3.17)分、(46.24±2.19)分,FD组为分别为(55.28±4.29)分、(54.48±5.37)分,比较差异有统计学意义(P<0.05).结论 功能性消化不良患者较正常人群有明显的负性心理问题,主要以焦虑及抑郁倾向更为明显.%OBJECTIVE To explore the mental health condition of functional dyspepsia (FD) patients. METHODS This study selected 120 cases with functional dyspepsia attending our clinic from January 2011 to December 2011 for investigation (FD group). 100 cases with normal physical examination at the same time were chosen as the control group. Eysenck Personality Questionnaire (EPQ) , Symptom checklist (SCL-90) , Self-rating Anxiety Scale (SAS) and Self rating Depression Scale (SDS) were used. RESULTS (1) EPQ: The average scores of E, N, P, L four dimensions in the control group was 50.48 ± 8.21, 53.42 ± 9.02, 51.33 ± 10.46, 52.89 ± 8.11 respectively. In the FD

  16. Relationship between symptoms and proximal stomach function in patients with functional dyspepsia%功能性消化不良症状和近端胃功能的关系

    Institute of Scientific and Technical Information of China (English)

    郭文娟; 张艳丽; 姚树坤; 尹立杰; 颜珏; 李红磊

    2012-01-01

    目的:探讨功能性消化不良(functional dyspepsia,FD)症状与近端胃敏感性、容受性及顺应性的关系.方法:记录32例健康志愿者和59例FD患者的基本人口学特征和消化不良症状,患者空腹行电子恒压器检查,将前端带有气囊的双腔聚乙烯导管经口插入受试者胃内,给予等压扩张,检测指标包括近端胃敏感性、容受性及顺应性;同样,所有受试者第二天空腹行胃排空功能检查,利用核素闪烁法测定胃的固体排空功能,得出全胃排空标准曲线并计算全胃半排时间.利用χ2和Logistic回归分析消化不良症状与近端胃功能关系.结果:44.07%的FD患者存在内脏敏感性增加,内脏敏感性正常组和增加组之间胃半排时间无差异.内脏敏感性增加的患者上腹痛症状发生率高于内脏敏感性正常的患者(P<0.01);上腹痛症状是内脏敏感性增加的相关因素(OR=4.430,P<0.05).37.29%的FD患者存在近端胃容受性减低,容受性正常组和减低组胃半排时间无差异.近端胃容受性减低的患者早饱症状的发生率高于近端胃容受性正常的患者(P<0.05);早饱症状是近端胃容受性减低的独立相关因素(OR=3.231,P<0.05).54.24%的FD患者存在顺应性减低,顺应性正常组和减低组之间胃半排时间及消化不良症状发生率均无显著差异(P>0.05).结论:FD患者的症状与近端胃功能障碍有关,上腹痛症状提示内脏敏感性增加,早饱症状提示近端胃容受性减低.%AIM: To investigate the prevalence of impaired proximal stomach function and its relationship to symptoms in patients with functional dyspepsia (FD).METHODS: Fifty-nine patients with FD and 32 healthy subjects (HS) were enrolled in this study. After an overnight fast of at least 12 h, a double-lumen polyvinyl tube with an adherent plastic bag that was finely folded was introduced through the patient's mouth. A gastric barostat was used to evaluate proximal

  17. 急性胃肠道感染相关功能性消化不良的初步研究%A preliminary study of acute gastrointestinal infection-associated functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    李为光; 李晓波; 戈之铮; 刘文忠

    2008-01-01

    目的 调查急性胃肠道感染相关功能性消化不良(PI-FD)的临床特点,初步探讨其可能的发生机制.方法 对原先无消化道症状的550例急性胃肠道感染患者随访半年,评估PI-FD的发生率及其症状特点,同时收集30例非特异性功能性消化不良(NS-FD)和20例健康志愿者,测定其胃黏膜肥大细胞(MC)的数量和活化水平;测定胃黏膜MC的分泌介质类胰蛋白酶含量和组胺释放量;电镜观察MC的状态及其与神经纤维的毗邻关系.结果 550例急性胃肠道感染患者中28例失访,随访6个月时功能性消化不良(FD)发生率为6.7%(35/522);PI-FD组的上腹痛、烧灼感和早饱的症状积分高于NS-FD组(P值均0.05).However,the number of activated mast cells in patients with PI-FD is significantly higher than that in patients with NS-FD.The total amount of tryptase in gastric mucoss and the histamine released in patients with PI-FD is higher than that in patients with NS-FD and healthy volunteers(P<0.05 for all).Under the electron microscope,the number of mast cells located within 5μm of nerve fibers in PI-FD patients was significant higher than that in other two groups(P<0.05 forall).Conclusions PI-FD is probably a specific type of functional dyspepsia.Epigastric pain,epigastric burning sensation,and early satiety are the major symptoms in these patients.Mast cells maybe involved in the pathogenesis of PI-FD.

  18. The relationship between gastric sensory function and early satiety in functional dyspepsia patients%功能性消化不良患者胃感觉功能与早饱症状的关系

    Institute of Scientific and Technical Information of China (English)

    何旭东; 徐章; 侯晓华

    2006-01-01

    目的了解功能性消化不良(functional dyspepsia,FD)患者的胃感觉功能与早饱症状的关系.方法将48例功能性消化不良患者按照是否存在早饱症状分为早饱组和非早饱组,其中早饱组24例(男女各12例),非早饱组24例(男女各12例).运用饮水负荷试验测定胃感觉功能,并与20例对照组的胃感觉功能进行比较.刚出现上腹部饱足感时的饮水量为初次饱足阈值,受试者出现完全饱足或因上腹部症状不能继续饮水时的饮水量即最大饱足阈值.结果功能性消化不良患者初次饱足阈值和最大饱足阈值均较对照组显著降低(433ml±60.2ml比503ml±32.4ml,P<0.01和784 ml±90.8 ml比1030 ml±84.8ml,P<0.01);功能性消化不良患者早饱组和非早饱组间初次饱足阈值和最大饱足阈值比较无明显差别(430ml±61.7ml比437ml±59.6ml,P>0.05和779ml±95.1 ml比788ml±87.9ml,P>0.05).50%的功能性消化不良患者初次饱足阈值降低,75%的患者最大饱足阈值降低.结论部分功能性消化不良患者确实存在胃感觉过敏,功能性消化不良患者胃感觉功能与早饱症状之间无明显关系.

  19. Variation of serum ghrelin and leptin in patients with functional dyspepsia%功能性消化不良患者血清Ghrelin及瘦素水平变化

    Institute of Scientific and Technical Information of China (English)

    陈莹; 刘文天; 方维丽

    2009-01-01

    目的 探讨功能性消化不良(FD)患者血清Ghrelin及瘦素水平变化及其临床意义.方法 60例FD患者,其中餐后不适综合征(PDS)30例,上腹痛综合征(EPS)30例,健康对照者30名,分别采用酶联免疫法和放射免疫法检测血清Ghrelin及瘦素水平.结果 FD组血清Ghrelin水平较对照组明显减低(P0.05).结论 FD患者血清Ghrelin和瘦素水平减低主要是由PDS患者血清水平改变所致.PDS的病理机制可能主要与胃肠运动异常相关;血清Ghrelin和瘦素在FD发病过程中存在相互作用,对其的检测可能有助于FD分型和指导治疗.%Objective To investigate the alteration of serum ghrelin and leptin in patients with functional dyspepsia (FD) and their clinical significance. Methods Sixty patients with FD [-30 patients with postprandial distress syndrome(PDS) and 30 patinets with epigastric pain syndrome(EPS)] were enrolled. Thirty healthy subjects were severed as controls. The serum ghrelin and leptin were measured by enzyme linked immunosorbent assay and radioimmunosorbent assay, respectively. Results The concentrations of serum ghrelin and leptin were both significantly lower in patients with FD than in controls (P0.05). Conclusions The alterations of serum ghrelin and leptin in PDS patients are responsible for their reduction in FD patients. The PDS may he associated with abnormalities in gastrointestinal motility. There is an interaction between serum ghrelin and leptin in development of FD. The detection of serum ghrelin or leptin is helpful in classification and treatment of FD.

  20. To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome:a randomized group sequential comparative trial

    Directory of Open Access Journals (Sweden)

    Huang Luqi

    2011-07-01

    Full Text Available Abstract Background In Traditional Chinese Medicine (TCM theory, functional dyspepsia (FD can be divided into different syndromes according to different clinical symptoms and signs, and the most common one is spleen-deficiency and qi-stagnation syndrome that can be treated by Chinese traditional patent medicine ---- two kinds of Zhizhu pills, between which the primary difference in ingredients is that one contains immature orange fruit of Citrus aurantium L.(IFCA and the other contains that of Citrus sinensis Osbeck (IFCS. The trial's objective was to compare the efficacy of two kinds of Zhizhu pills on symptom changes in patients with FD of spleen-deficiency and qi-stagnation syndrome. Methods A randomized, group sequential, double-blinded, multicenter trial was conducted in patients with FD of spleen-deficiency and qi-stagnation syndrome at 3 hospitals in Beijing between June 2003 and May 2005. Participants were randomly allocated into two groups (IFCA group and IFCS group in a 1:1 ratio, and respectively took one of the two kinds of Zhizhu pills orally, 6 g each time, 3 times a day, for 4 weeks. Statistical analysis was performed with use of a group sequential method, the triangular test (TT. Results A total of 163 patients were randomized, and 3 patients were excluded from analysis because of early dropouts, leaving 160 patients (IFCA group: n = 82; IFCS group: n = 78 for statistical analysis. Three interim analyses were done after 62, 116, and 160 patients had completed their 4-week treatment, respectively. At the third interim analysis, the sample path crossed the upper boundary and the trial was stopped, the cure-markedly effective rates were 45% for IFCS group and 67% for IFCA group, respectively, the one-sided p-value was 0.0036, the median unbiased estimate of the odds ratio (OR for the benefit of IFCA relative to IFCS was 2.91 with 95%CI: 1.40 to 6.06. No adverse events were observed in the two groups. Conclusions Zhizhu pills

  1. Clinical Observation of Tandospirone in Treating Functional Dyspepsia Patients with Anxiety%坦度螺酮治疗功能性消化不良合并焦虑的临床观察

    Institute of Scientific and Technical Information of China (English)

    庞敏; 朱丽明; 方秀才; 王智凤; 柯美云

    2015-01-01

    目的:观察坦度螺酮治疗功能性消化不良(functional dyspepsia, FD)合并焦虑状态患者的疗效和安全性。方法2012年3月至2013年12月北京协和医院消化内科门诊就诊的31例FD合并焦虑状态患者,既往常规治疗无效,口服坦度螺酮10 mg/次,3次/d,治疗4周,比较治疗前、治疗2周及治疗4周时 FD症状积分;比较治疗前和治疗4周时Zung焦虑、抑郁自评量表( Zung anxiety and depression self-rating scales, SAS、 SDS )评分,汉密尔顿焦虑、抑郁量表(Hamilton anxiety and depression scales, HAMA、 HAMD)评分,生活质量(SF-36)评分,液体营养餐负荷试验的变化,分析评价疗效,同时观察记录不良反应。结果治疗前、治疗2周、4周时总体症状积分分别为10.45±5.66、8.48±5.96、7.39±5.46,治疗2周、4周时均较治疗前明显下降(P=0.002,0.020);餐后饱胀不适和早饱两个单项症状积分在治疗2周、4周时较治疗前明显下降,差异有统计学意义(P均<0.05)。 SAS、 HAMA及HAMD评分治疗4周较治疗前下降(P=0.028,0.002,0.000)。生活质量(SF-36)评分中生理功能、躯体疼痛、总体健康状况分数在治疗4周时有改善(P=0.033,0.022,0.041)。液体营养餐负荷试验阈值饮入量和饱足饮入量治疗前后差异无统计学意义(P=0.285,0.532)。治疗期间有5例(16.1%)患者出现皮疹、瘙痒等不良反应,其中1例因不良反应停药。结论坦度螺酮治疗功能性消化不良合并焦虑患者安全有效,可以作为常规治疗无效时的一个选择。%Objective To observe the efficacy and safety of tandospirone in treating patients with func-tional dyspepsia ( FD) co-morbid with anxiety.Methods Thirty-one patients diagnosed with FD co-morbid with anxiety and failed to respond to routine therapy were recruited from the outpatient

  2. 食积因素对 FM 1流感病毒感染小鼠免疫功能影响的实验研究%Experimental Study of the Impact of Dyspepsia on Immune Function on Influenza Virus Infected Mice

    Institute of Scientific and Technical Information of China (English)

    施金凤; 于河; 王上; 谷晓红

    2013-01-01

    目的:通过检测不同时相食积复合流感病毒(FM1)感染小鼠血清免疫球蛋白M(IgM)、IFN-γ、IL-4及TH1/TH2水平,探讨食积对流感病毒感染(FM1)小鼠免疫功能的影响。方法:通过喂饲小鼠高蛋白、高热量特制饲料复制食积模型,在此基础上,经鼻感染FM1甲型流感病毒,复制病毒性感染模型,于感染后第1、3、5天,分别检测各组小鼠血清IgM、IFN-γ、IL-4及TH1/TH2水平。结果:小鼠感染FM1流感病毒后第5天,单纯感染组、食积感染组小鼠血清IgM含量均较正常组下降,且食积感染组结果差异有统计学意义(P<0.05),食积感染组较单纯感染组正常组血清IgM含量明显降低,且结果有统计学意义(P<0.01);病毒感染后第1、3、5天,单纯感染组、食积感染组小鼠血清TH1(IFN-γ)/TH2(IL-4))水平均较正常组降低,且在第3天差异有统计学意义(P<0.05),第3、5天食积感染组较正常组降低更为明显,且差异有统计学意义(P<0.05)。结论:食积可能通过影响机体IgM、IFN-γ、IL-4及TH1/TH2水平对流感病毒感染( FM1)小鼠的免疫失衡产生影响,从而提示食积因素可能对流感的发生发展产生了影响。%Objective:To investigate the impact of dyspepsia on immune function on influenza virus ( FM1 ) infected mice , through de-tecting the serum levels of immunoglobulin M (IgM), Interferon-γ(IFN-γ), Interleukin-4(IL-4)and TH1/TH2.Methods:The mice dyspepsia model was built by feeding mice with high protein-calorie food, then nasal infected with FM1 influenza A virus, randomized to normal group , infected group , and infected and dyspepsia group on D 3 and D5 after infection , detected the serum level of IgM , IFN-γ, IL-4 and TH1/TH2 levels.Results:Mice were infected with FM1 virus at D5, the IgM level of both infected groups were significantly higher than that of the normal group (P<0.05).The

  3. Application of Flupentixol and Melitracen Tablets Combined With Mosapride in the Treatment of Functional Dyspepsia%莫沙必利联合氟哌噻吨美利曲辛片在功能性消化不良治疗中的应用

    Institute of Scientific and Technical Information of China (English)

    戚海燕

    2016-01-01

    目的:探讨莫沙必利联合氟哌噻吨美利曲辛片在功能性消化不良治疗中的临床应用。方法选择2015年3月~2016年2月在我院治疗的功能性消化不良患者60例,随机分为对照组和治疗组各30例,对照组给予莫沙必利治疗,治疗组在对照组的基础上联合氟哌噻吨美利曲辛片治疗,比较两组患者的临床疗效及HAMD评分结果。结果治疗后治疗组的总有效率为96.67%,高于对照组的83.33%,且治疗组患者HAMD评分优于对照组,两组比较差异有统计学意义(P<0.05)。结论莫沙必利联合氟哌噻吨美利曲辛片在功能性消化不良治疗中疗效显著。%Objective To explore the clinical application of mosapride combined with flupentixol and melitracen tablets in the treatment of functional dyspepsia.Methods From March 2015 to February 2016, 60 patients with functional dyspepsia in our hospital were randomly divided into control group and treatment group with 30 cases in each group, the control group was given mosapride treatment, the treatment group in the control group on the basis of lfupentixol and melitracen tablets combined with treatment, compared two groups of patients with clinical curative effect and HAMD score.Results After treatment in the treatment group the total effective rate of 96.67% was signiifcantly higher than the control group and 83.33% patients in the treatment group HAMD score than the control group, there was signiifcant difference between two groups (P<0.05). Conclusion Curative effect of mosapride combined with flupentixol and melitracen tablets in the treatment of functional dyspepsia.

  4. 根除幽门螺杆菌感染在治疗慢性胃炎伴消化不良中的作用%Effect of eradication of helicobacter pylori infection in the treatment of chronic gastritis complicated with dyspepsia

    Institute of Scientific and Technical Information of China (English)

    付堂高

    2015-01-01

    Objective:To explore the effect of eradication of helicobacter pylori infection in the treatment of chronic gastritis complicated with dyspepsia.Methods:100 patients with chronic gastritis complicated with dyspepsia were selected,they were randomly divided into the observation group and the control group with 50 cases in each,the control group was given oral omeprazole,the observation group was treated with clarithromycin and amoxicillin on the basis of the control group,we compared the therapeutic effect of two groups.Results:The total effective rate of 98.0% in the observation group was significantly higher than 74.0% in the control group(P<0.05),the HP eradication rate of 100.0% in the observation group was significantly higher than 4.0% of the control group(P<0.05).Conclusion:The effect of eradication of helicobacter pylori infection in the treatment of chronic gastritis complicated with dyspepsia was significant.%目的:探讨根除幽门螺杆菌感染在治疗慢性胃炎伴消化不良中的作用。方法:收治慢性胃炎伴消化不良患者100例,随机分成观察组和对照组各50例,对照组给予奥美拉唑口服,观察组在对照组的基础上加用克拉霉素和阿莫西林,比较两组的治疗效果。结果:观察组总有效率98.0%,明显高于对照组的74.0%(P<0.05),观察组 HP 根除率100.0%,明显高于对照组的4.0%(P<0.05)。结论:根除幽门螺杆菌感染方案治疗慢性胃炎伴消化不良的临床疗效显著。

  5. Curative effect analysis of lysine inosite vitamin B12 combined with mosapride in the treatment of children with functional dyspepsia%赖氨肌醇维B12联合莫沙必利治疗儿童功能性消化不良疗效分析

    Institute of Scientific and Technical Information of China (English)

    郑烜

    2016-01-01

    目的:探讨赖氨肌醇维B12联合莫沙必利治疗儿童功能性消化不良的安全性与疗效。方法:收治功能性消化不良患儿628例,随机分为两组。对照组给予枸橼酸莫沙必利片治疗,治疗组给予赖氨肌醇维 B12联合莫沙必利治疗,比较两组症状评分、临床疗效与不良反应发生情况。结果:治疗组治疗后症状评分显著低于对照组,差异有统计学意义(P<0.05)。治疗组总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论:赖氨肌醇维B12联合莫沙必利治疗儿童功能性消化不良临床疗效显著,安全性高。%Objective:To investigate the safety and curative effect of lysine inosite vitamin B12 combined with mosapride in the treatment of children with functional dyspepsia.Methods:628 cases of children with functional dyspepsia were divided into two groups randomly.The control group was treated with mosapride citrate tablets.The treatment group was treated with lysine inosite vitamin B12 combined with mosapride.The symptom scores,clinical curative effect and adverse reactions in the two groups were compared.Results:After treatment,the symptom scores of the treatment group were significantly lower than that of the control group, and the difference was statistically significant (P<0.05).The total effective rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant (P<0.05).Conclusion:Lysine inosite vitamin B12combined with mosapride in the treatment of children with functional dyspepsia had significant curative effect and high safety.

  6. 半夏和胃汤治疗功能性消化不良伴睡眠障碍的效果观察%The Effect Study on Pinellia Tuber and Stomach Decoction in Treatment of Functional Dyspepsia Complicated With Sleep Disorders

    Institute of Scientific and Technical Information of China (English)

    龙海

    2015-01-01

    目的:观察半夏和胃汤治疗功能性消化不良伴睡眠障碍的效果。方法搜集2013年7月~2014年8月我院接受的功能性消化不良伴睡眠障碍40例患者,分为对照组与实验组。对照组18例治疗方法为西药,实验组22例治疗方法为半夏和胃汤。观察对照组与实验组的治疗效果,并比较。结果与对照组相比,实验组治疗有效率较高,有明显差异,有统计学意义(P<0.05)。结论半夏和胃汤治疗功能性消化不良伴睡眠障碍的效果显著,有效率高。%Objective The effect study on pinel ia tuber and stomach decoction in treatment of functional dyspepsia complicated with sleep disorders is to be investigated. Methods Choose 40 patients of functional dyspepsia complicated with sleep disorders who are treated in hospital from July 2013 to August 2014 and separate them into control group and study group; 18 patients in control group are given western medicine treatment; while 22 patients in study group are given pinel ia tuber and stomach decoction treatment; and then observe and compare attendance efficacy of the two groups. Results Compared to control group, the treatment efficacy in study group is much higher;there is a treatment differential between the two groups, and such a differential has statistic value(P<0.05). Conclusion Pinel ia tuber and stomach decoction is of efficacy and efficiency in treatment of functional dyspepsia complicated with sleep disorders, which is quite worthwhile to be promoted.

  7. 复合凝乳酶胶囊治疗不同类型儿童消化不良的临床应用体会%Clinical application of gastropylor complex capsules treatment for different types of children dyspepsia

    Institute of Scientific and Technical Information of China (English)

    刘亚昆; 杨颖

    2014-01-01

    目的:探讨复合凝乳酶胶囊治疗不同类型的儿童消化不良临床效果。方法:2011年1月-2012年2月收治消化不良患儿150例,将不同类型的患儿按照食欲不振、上腹痛上腹胀、恶心呕吐类分为3组。3组都给予相同剂量的复合凝乳酶胶囊治疗,观察各自消化不良症状的改善情况。结果:食欲不振类治愈20例(40%),有效25例(50%),无效5例(10%)。上腹痛上腹胀类治愈10例(20%),有效15例(30%),无效25例(50%)。恶心呕吐类治愈5例(10%),有效25例(50%),无效20例(40%)。每两组之间比较差异存在统计学意义(P<0.05)。结论:在治疗各种消化不良症状的时候,复合凝乳酶胶囊对食欲不振类的疗效最佳,起效快,不良反应少,其疗效值得肯定。%Objective:To explore the clinical effect of gastropylor complex capsules treatment for different types of children dyspepsia.Methods:150 patients with indigestion were selected from January 2011 to February 2012.According to the loss of appetite,upper abdominal pain,abdominal distention,nausea and vomiting,they were divided into 3 groups.The 3 groups were given the same dose gastropylor complex capsules,and we observed the improvement of dyspeptic symptoms.Results:In the loss of appetite,20 cases(40% ) were cure;25 cases(50% ) were effective;5 cases(10% ) were invalid.In the upper abdominal pain, abdominal bloating,10 cases(20%) were cure;15 cases(30%) were effective;25 cases(50%) were invalid.In the nausea and vomiting, 5 cases(10%) were cured;25 cases(50%) were effective,20 cases(40%) were invalid.Comparison between every two groups,the difference was statistically significant(P<0.05).Conclusion:In the treatment of various dyspeptic symptoms,efficacy of gastropylor complex capsules for loss of appetite class is the best.The onset of gastropylor complex capsules is quick;adverse reactions is little;the curative effect is worth affirmation.

  8. 以舒必利为基础治疗功能性消化不良的临床研究%Clinical Study Sulpiride Based Treatment of Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    檀伯海

    2013-01-01

      目的:评价以舒必利片为基础的FD综合治疗疗效。方法:选取2009年5月-2011年5月华北石油二部医院治疗的符合罗马Ⅲ标准的212例FD患者,随机分为两组,治疗组:根据病情常规给予莫沙必利片、兰索拉唑片等药物治疗,幽门螺杆菌病阳性者给予根除幽门螺杆菌治疗。对照组:在治疗组基础上加用舒必利片50 mg/次,3次/d,饭前口服,连续治疗4周后停药,停药后当日及半年后评价疗效2次;分别记录治疗前后上腹痛、上腹饱胀、上腹胀感、嗳气、恶心、呕吐等症状,观察评分变化情况,综合评价治疗疗效。结果:212例FD患者能够完成治疗及半年后随访到180例,治疗组82例,有效率50.00%,对照组98例,有效率78.57%。结论:功能性消化不良患者在对症治疗基础上加用舒必利可使大多数FD患者的症状改善,明显提高疗效,并且停药后可使患者保持更长的缓解率。%  Objective:To evaluate the efficacy of sulpiride in the treatment of functional dyspepsia.Methods:212 patients with FD (Rome Ⅲcriteria) were enrolled in this study between 2009.05-2011.05 in the SHHO hospital.The patients were randomly divided into two groups. Patients in Group I were given mosapride and lansoprazole. Patients with Helicobacter pylori infection were given eradiation treatment. Group II,based on the therapy of Group I,add sulpiride of 50 mg per time and tree times per day before dinner for 4 weeks continually. Evaluate the therapeutic effect after drug withdrawal and half a year for two times. Score the symptoms,including epigastric pain,epigastric fullness,aerophagia,nausea,vomiting .etc,observe the process,and evaluate its efficacy.Results:212 cases completed the treatment,82 cases of Group I take a improvement percentage of 50.00%,98 cases of group II take a improvement percentage of 78.57%.Conclusion:FD patients taking sulpiride on the bases of their

  9. Study on influence of helicobacter pylori infection on gastric electrical parameters in functional dyspepsia%幽门螺杆菌感染影响功能性消化不良胃电参数探讨

    Institute of Scientific and Technical Information of China (English)

    周慧明; 沈磊

    2015-01-01

    Objective To investigated the influence of helicobacter pylori (HP) infection on gastric electrical parameters in functional dyspepsia (FD) .Methods The patients with FD from January 2011 to December 2012 were selected and divided into the HP positive group and the HP negative group .50 healthy persons undergoing physical examination were selected as the healthy control group .The adverse symptoms and surface electrogastrogram were examined and the data were analyzed .Results The HP negative groups was lower than the HP positive group in the aspects of abdominal pain ,belching ,vomiting ,regurgitation ,early satiety and heartburn (P < 0 .05) ;relative to the healthy control group ,T% ,B% ,N% ,DF and DP before and after meal in the HP positive group and DF ,DP and N%in the HP negative group had statistically significant differences (P< 0 .05) ;relative to the HP negative groups ,B% , N% ,DF and DP before and after meal in the HP positive group had statistically significant differences (P < 0 .05) . Conclusion HP infection could aggravate the adverse symptoms and lead to the gastric electric rhythm disorders in FD patients .%目的:探讨幽门螺杆菌感染对功能性消化不良胃电参数的影响。方法选取该院2011年1月至2012年12月收治的功能性消化不良患者,分为幽门螺杆菌阳性组和幽门螺杆菌阴性组,另选取该院门诊体检的健康者50例作为健康对照组,分别检测各组患者的不良症状和体表胃电图,分析数据。结果幽门螺杆菌阴性组在腹痛、暖气、呕吐、反流、早饱和烧心低于幽门螺杆菌阳性组(P<0.05);相对于健康对照组,幽门螺杆菌阳性组在餐前后正常胃电慢波百分比(N%)、餐后胃动过缓百分比(B%)、餐前后胃动过速百分比(T %)、主频(DF)、主功率(DP)和幽门螺杆菌阴性组在餐后 N%、DF 、DP 均差异有统计学意义(P<0.05);相对于幽门螺杆菌阴性组

  10. 具心理障碍的功能性消化不良41例临床分析%Analysis of 41 cases with functional dyspepsia complicated by psychological disorders

    Institute of Scientific and Technical Information of China (English)

    贾绮宾; 李笠; 阴英; 樊宇靖; 蓝宇

    2011-01-01

    2008年6月至2009年1月我院1320例消化科就诊患者中,功能性消化不良(FD)患者277例(20.9%);其中经明尼苏达多相人格问卷(MMPI)结论列入心理障碍者为41例,占FD患者的14.8%.41例出现疑病及躯体化倾向者38例92.7%,焦虑与抑郁并存的25例(60.9%).主诉症状上腹痛40例(97.6%),餐后饱胀31例(75.6%),早饱266例(63.4%),恶心15例(36.6%),烦躁、多虑、乏力、精力不集中、记忆力减退、失眠多梦等主诉占80.0%以上.心理疏导合并抗焦虑抑郁药物治疗4周末,显效5例,有效31例,无效3例,总有效率87.8%.提示,功能性消化不良患者焦虑抑郁情绪发生率较正常人群显著升高.心理障碍患者具有明显的疑病和躯体化倾向.心理疏导配合抗焦虑抑郁药物治疗能取得很好的效果.%In our gastroenterology clinic from Jun. 2008 to Jan. 2009, 20. 9% (277/1320) patients were diagnosed with functional dyspepsia (FD) and 14. 8% (41/277) of them with psychological problems according to Minnesota Multiphasic Personality Inventory (MMPI). In those with psychological disorders,92.7% were found with somatization, 60. 9% with depression and anxiety, 97.6% with abdominal pain,75.6% with bloating, 63.4% with early fullness and 36. 6% with nausea. More than 80% patients with anxiety and depression complained irritability, worry, fatigue, poor concentration, memory loss and insomni.a. After 4 weeks of psychological consultation and anti-depression treatment, 5 patients had significant improvement, 31 had improvement and 3 had no response. The overall response rate was 87. 8%.In summary,there is a high prevalence of depression and anxiety in population with FD. Hypochondria and somatization are common among these patients. Psychological consultation with anxiolytic drugs may have good therapeutic effects.

  11. GASTRODUODENAL DISEASE IN NIGERIANS WITH DYSPEPSIA

    African Journals Online (AJOL)

    and sex-matched apparently normal control were screened for H. pylori lgG using lmmunocombRll kits. Each of the 55 ... Keywords: dyspepsiaf Helicobacter pylori serology; gastroduodenal disease .... infection in the pathogenesis of. '/>9.

  12. 疏肝健脾和胃益肾膏方治疗功能性消化不良90例%Observation of Clinical Efficacy of Soothing Liver and Strengthening Spleen and Tonifying Kidney Herbal Paste in Treatment of 90 Patients with Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    黄天生; 郭召平; 尚莹莹; 徐新利; 肖定洪; 吴晓华

    2013-01-01

    Objective:To investigate the clinical efficacy of soothing liver and strengthening spleen and tonifying kidney herbal paste in the treatment of functional dyspepsia.Methods:180 patients were randomly divided into herbal paste group and decoction group.After 4 weeks,the effective rate of single symptom and the disease was observed.Results:The total effective rate was 87.77% for the herbal paste group and 81.11% for the decoction group.There was no significant difference of the total effective rate between the two groups (P > 0.05).However,herbal paste group was better than decoction group in treating ventosity,early satiety,sicchasia,ructus.Conclusion:Soothing liver and strengthening spleen and tonifying kidney herbal paste in the treatment of functional dyspepsia has exact effects.%目的:观察膏方治疗功能性消化不良(FD)的临床疗效.方法:将接受膏方治疗的90例FD患者与服用煎剂的FD患者90例进行比较,连续治疗4周后,观察两组单个症状有效率及总有效率.结果:膏方组和煎剂组的临床症状总有效率分别为87.77%和81.11% (P >0.05).膏方组在改善腹胀、早饱、恶心、嗳气等方面优于煎剂组(P<0.01).结论:膏方治疗FD具有肯定疗效.

  13. A clinical study of functional dyspepsia and mental disorder co-morbidity%功能性消化不良与精神心理障碍共病的临床研究

    Institute of Scientific and Technical Information of China (English)

    朱丽明; 洪霞; 方秀才; 史丽丽; 熊娜娜; 王智凤; 魏镜

    2015-01-01

    Objective To investigate the co-morbid state of mental disorder in patients with functional dyspepsia (FD) in a tertiary general hospital in China and explore the risk factors of the co-morbidity of FD and major depressive disorder(MDD).Methods This study was designed as a bilateral evaluation and structural psychiatric interview.Patients with FD and newly diagnosed outpatients with MDD in gastrointestinal and psychological departments were enrolled.FD was defined by Rome Ⅲ criteria.The questionnaires including symptoms of FGIDs Roma Ⅲ,the composite international diagnostic interview (CIDI 3.0) Chinese version,the Hamilton depression/anxiety rating scale (HAMD/HAMA),Montgomery-Asberg depression scale (MADRS) were involved in this study.All patients were administered by well trained physicians and investigators in face to face interview.Results A total of 69 patients have completed the valid questionnaires and interview,among whom 42 met FD criteria (FD group) and 27 with FD co-morbid MDD (co-morbid group).Male to female ratios were 17∶25 and 10∶ 17,the mean age (42.1 ± 13.3) and (43.1 ± 15.3)years respectively.The life-long co-morbidity of FD and MDD was 39.1% (27/69),while 31.9% (22/69) patients with FD were accompanied with other mental disorders rather than MDD.Patients in FD co-morbid MDD group had significantly more severe depression than those in FD group with HAMD-17 score 21.6 ± 8.0 and 14.5 ± 7.6,HAMA score 21.2 ± 9.0 and 14.9 ± 7.5 respectively (all P < 0.01).Logistic regression analysis showed that high score of MADRS and complication with functional anorectal disorder may be the risk factors of FD co-morbid MDD [OR (95% CI) 1.12 (1.06-1.19) and 7.07(1.12-44.53)].Conclusions The co-morbidity rate of FD with MDD in our hospital is high.In addition to MDD,other mental disorders also need to be paid attention in FD patients.FD co-morbid MDD patients suffered more severe depression and anxiety.The high score of MADRS and complication

  14. 功能性消化不良患者钡餐胃动力检查与胃泌素观察%The value of gastric barium meal dynamic radiography for functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    赵青; 金玉莲; 洪洋; 方继良; 韦小燕; 刘志顺

    2012-01-01

    目的:研究功能性消化不良(FD)患者钡餐后胃动力与血清胃泌素及临床症状评分变化的相关关系.方法:根据罗马Ⅲ标准纳入17例FD患者(FD组),进行临床FD评分,检测空腹血清胃泌素,行空腹胃钡餐动态摄影检查,与10例正常人(正常人组)对比.胃钡餐动态摄影主要测量指标包括:胃潴留液高度、胃中间横带宽度、蠕动波频率、蠕动波最大宽度、蠕动波最大深度、蠕动波通过时间;胃泌素检查采用钡餐当天清晨空腹血清学检查.对FD患者临床评分与FD胃动力检测各项指标及胃泌素之间进行相关性分析.使用SPSS 13.0软件,采用配对t检验或符号秩检验;相关性分析采用统计软件Sas 8.2简单线性相关及Spearman秩相关指数分析.结果:FD患者与正常人临床症状评分差异有统计学意义(P=0.000 0).FD患者与正常人血清胃泌素水平差异有统计学意义(P=0.006 3).FD患者与正常人胃动力检测指标胃潴留液高度、胃中间横带宽度、蠕动波频率、蠕动波通过时间差异有统计学意义(P=0.000 0;P=0.000 0;P=0.000 2;P=0.000 6).上腹疼痛与胃蠕动波频率呈负相关,胃泌素与钡餐胃动力指标无明显相关性.结论:胃钡餐动态摄影可直观观察胃动力变化,胃泌素体现了胃动力相关激素水平,可作为评价FD及其疗效的客观指标.%Objectives:To evaluate the gastric barium meal dynamic radiography in the diagnosis of functional dyspepsia(FD)in patients with gastric motility abnormality. Methods:Seventeen FD patients(group A)were recruited by the Rome III criteria con trolled with ten healthy volunteers(group B). FD Questionaire was scored by all subjects. They all received the examination of the gastric barium meal dynamic radiography (one minute video) and the blood-draw of serum gastrin before breakfast. The imaging indexes included the height of gastric retention liquid,the width of midgastric transverse band(MTR) ,the

  15. Randomized Controlled Trials on Compound Shenqi Soft Capsules in Children with Functional Dyspepsia%复方参芪软胶囊治疗儿童功能性消化不良的随机对照试验

    Institute of Scientific and Technical Information of China (English)

    李燕; 王春艳; 李云霞; 郑丽娜; 杨丽君

    2016-01-01

    目的:评价复方参芪软胶囊对儿童功能性消化不良(FD)的疗效。方法:采用分层随机平行组对照非盲法设计,将功能性消化不良患儿按年龄分层后随机入组。观察组给予复方参芪软胶囊,对照组给予复方参芪颗粒。1个月为一疗程。比较观察组与对照组在改善腹痛、腹胀、食少早饱、嗳气反酸、恶心呕吐等方面的临床疗效,并监测两组患者儿的胃电指标变化。结果:复方参芪软胶囊能明显改善患儿腹痛、腹胀、食少早饱、嗳气反酸、恶心呕吐等临床症状,能明显增加正常胃电节律,减少过缓胃电节律,与治疗前比较有显著性差异(P <0.05);在改善腹痛、腹胀、食少早饱,减少胃动过缓方面,与复方参芪颗粒比较有显著性差异(P<0.05);观察组总有效率为91.9%,对照组总有效率为78.3%,两组比较有显著性差异(P <0.05)。结论:复方参芪软胶囊治疗儿童功能性消化不良疗效满意,不良反应少见,适合临床推广应用。%Objective:To evaluate the clinical effects of compound Shenqi soft capsules in the children with functional dyspepsia(FD). Methods:A stratified random,parallel,control and non-blind design was used,and the children with FD were randomly divided into groups after stratified by age. The children in the trial group were given compound Shenqi soft capsules,one capsule for the children with age under three and two capsules for the children with age over three,tid. The control group was treated with compound Shenqi granules,half a bag for the children with age under three and 1 bag for the children with age over three,tid. The treatment course was one month. The two groups were compared by the symptoms of bellyache,abdominal distension,early satiety,belching and nausea. The electrogastrogram was analyzed in two groups. Results:Compound Shenqi soft capsules could improve the symptoms of

  16. Combination therapy of azintamide and domperidone in functional dyspepsia: a randomised, double-blind, placebo-controlled trial%复方阿嗪米特肠溶片联合多潘立酮治疗功能性消化不良的随机、双盲、安慰剂对照临床研究

    Institute of Scientific and Technical Information of China (English)

    赵莉; 许乐; 李琪; 王秀娣; 王冬梅; 王昭钢

    2011-01-01

    Objective To study the efficacy and safety of combined therapy of compound azintamide and domperidone in functional dyspepsia. Methods A randomised, double-blind, placebo-controlled trial.Two hundred and eight patients with functional dyspepsia were randomly grouped into group A (experimental group, 102 cases) and group B (control group, 106 cases). The patients in the group A were given 2 tablets of compound azintamide 3 times a day in addition to domperidone 10 mg 3 times per day for four weeks. The patients in the group B were only given domperidone 10 mg 3 times per day for 4 weeks. The therapeutic efficacy was evaluated by modified Severity of Dyspepsia Assessment (mSODA) and Global Patient Assessment (GPA). Results Subscore in mSODA:the change of bloating/pain intensity score in group A is -12.35±5.48 while group B is -10.52±4.65(P=0.009), the change of non-bloating/pain symptoms score in group A is -5.75±3.31 while group B is - 4. 86 ± 2.65 (P=0.033), and the change of satisfaction score in group A is 7. 09 ± 3. 78 while group B is 5.62 ± 3. 54 (P = 0. 004). The response rate in group A is 89. 2% which is significantly higher than 76.4% in group B (P=0. 015). Other symptoms for response assessment included loss of appetite, early satiety, fullness after meal, diarrhea. No severe side-effect was found in both groups. Conclusions Combined therapy of compound azintamide and domperidone may lead to bigger improvement in overall efficacy and health related quality of life in patients with functional dyspepsia than use of motility medicine alone. Potential mechanisms that may account for the efficacy of compound azintamide in functional dyspepsia include modulation of visceral sensitivity and/or gastrointestinal motility.%目的 评估复方阿嗪米特肠溶片与促动力剂联合使用对功能性消化不良(FD)患者症状和生活质量的影响.方法 随机、双盲、安慰剂对照临床试验.卫生部北京医院门诊就诊的208例符合罗马

  17. Could gastric histology be a useful marker for making decision on Helicobacter pylori eradication therapy in patients with dyspepsia? É a histologia gástrica um marcador útil na decisão de erradicar o Helicobacter pylori nos pacientes com dispepsia?

    Directory of Open Access Journals (Sweden)

    Severino Marcos Borba de Arruda

    2009-09-01

    Full Text Available CONTEXT: It still remains an open debate whether Helicobacter pylori eradication is beneficial or not for the improvement of symptoms in functional dyspepsia. Differences in geographic distribution, the worldwide H. pylori genetic variability and the fact that the outcome of infection is strongly related to the virulence of the infecting strain are factors that might be driving ongoing controversies. OBJECTIVE: To study the correlation between gastric histology and H. pylori serology status in patients with dyspepsia. METHODS: This is a cross-sectional study where 40 consecutive dyspeptic patients (28 women and 12 men, mean age 48.5 years with endoscopically normal stomachs were selected from the endoscopy unit at a university hospital in Recife, PE, Northeast of Brazil, between March 1998 and July 1999. Patients underwent gastric mucosal biopsy and serological tests (anti-Hp and anti-CagA antibodies. Gastric biopsies were examined using H-E and Giemsa stains and gastritis was classified and graded (mild, moderate or severe according to "the updated Sydney System - Houston, 1994". RESULTS: Among 40 patients with dyspepsia the gastric histology revealed that about ¼ had moderate (25% or severe (2.5% gastritis. This subgroup of patients also had a greater positive frequency of anti-Hp (100% vs 41%; P = 0.0005 and anti-CagA (91% vs 58%; P = 0.09 antibodies when compared with those with normal histology (27.5% or mild gastritis (45%. CONCLUSION: Since upper gastrointestinal endoscopy is part of the functional dyspepsia investigation and serology for anti-CagA antibody is not available in daily clinical practice, by biopsying gastric mucosa we would only be able to selectively apply H. pylori eradication therapy for those with histology that best correlate with virulent infecting strains (moderate or severe gastritis - around ¼ of our study patients with dyspepsia.CONTEXTO: O benefício da terapia de erradicação do H. pylori como parte do

  18. Clinical efficacy observation on pediatric functional dyspepsia treated with Simotang oral liquid and Bifico%四磨汤口服液联合双歧杆菌三联活菌胶囊治疗小儿功能性消化不良疗效观察

    Institute of Scientific and Technical Information of China (English)

    齐冰

    2016-01-01

    Objective To observe the clinical effect of Simotang oral liquid and Bifico on pediatric functional dyspepsia.Methods According to the random number table,1 14 cases of pediatric functional dys-pepsia were randomly divided into the control group and the observation group,each groups with 57 cases;the control group was treated with Simotang oral liquid,while observation group with Bifico on the base of control group;the effects of two groups were compared.Results After treatment,the effect of observation group was significantly better than control group(P <0.05);the score decrease of poor appetite,abdominal distension,nausea and vomiting and loose stool indigestion was greater in the observation group than that of control group(P <0.05);the level increase of gastrin and motilin in the observation group was better than that of control group;the level decrease of nitrogen monoxidum in the observation group was better than that of control group(P <0.05).Conclusion In treating pediatric functional dyspepsia,combined therapy of Simotang oral liquid and Bifico can increase curative effect and improve symptom and is safe,so it is worthy of clinical promotion.%目的:观察四磨汤口服液联合双歧杆菌三联活菌胶囊治疗小儿功能性消化不良的疗效。方法2013年9月至2015年11月河南省西华县人民医院儿科收治功能性消化不良患儿114例,随机分为对照组和观察组各57例。对照组给予四磨汤口服液治疗,观察组在对照组基础上给予双歧杆菌三联活菌胶囊治疗,疗程5 d。观察两组治疗效果及食欲不振、腹胀、恶心呕吐及便溏不消化等症状变化;患儿血清一氧化氮、胃泌素、血浆胃动素水平变化。结果观察组疗效优于对照组,差异有统计学意义(P <0.05);观察组食欲不振、腹胀、恶心呕吐、便溏不消化评分下降程度高于对照组,差异有统计学意义(P <0.05);观察组胃泌素、胃动素水平升高及一氧

  19. Clinical Analysis of Trimebutine Combined with Compound Digestive Enzymes in the Treatment of Functional Dyspepsia%马来酸曲美布汀联合复方消化酶治疗功能性消化不良的临床研究

    Institute of Scientific and Technical Information of China (English)

    郑丹; 王萍; 张恒; 吴杰

    2012-01-01

    Objective To study the efficacy and safety of combined therapy of trimebutine and compound digestive enzymes on functional dyspepsia. Methods 210 patients with functional dyspepsia were randomly grouped into experimental group (105 cases) and the controls(105 cases). The patients in the experimental group were given trimebutine 200 mg 3 times per day before meals and then were taken the compound digestive enzymes 3 times a day after meals for 4 weeks. The patients in the control group were only given trimebutine 200 mg 3 times per day before meals for 4 weeks. The treatment efficacy and side effects were compared between the two groups by chi square test. Results The general treatment efficacy in the experimental group was superior to the controls(88. 6% vs 63. 8% ,P <0. 05 ) . The symptoms of upper abdominal pain,abdominal distention,early satiety and stomach bum in the patients in the experimental group were more improved than in the control group. The experimental group had been shown quicker efficacy than the controls. No severe side-effects were found in the both groups. Conclusion Combined therapy of trimebutine and compound digestive enzymes can more significantly improve general efficacy and symptoms in patients with functional dyspepsia than single use of motility medicine trimebutine.%目的 观察曲美布汀联合复方消化酶胶囊治疗功能性消化不良的临床疗效和安全性.方法 将210例功能性消化不良患者随机分为两组,每组105例,两组均口服曲美布汀片,三餐饭前30 min服用200 mg.试验组加服复方消化酶胶囊,三餐后30 min服用2粒.4周后观察疗效.结果 试验组治疗总有效率明显优于对照组,分别为88.6%和63.8% (P <0.05).对上腹痛、餐后饱胀、早饱、上腹烧灼感症状改善情况进行比较,试验组治疗前后的症状总积分及症状改善有效率较对照组有显著性差异(P<0.05),而且起效时间明显缩短.两组患者均未发现严

  20. Relationship between psychosocial factors and duodenal mast cells in patients with functional dyspepsia%功能性消化不良患者精神心理因素与十二指肠肥大细胞的相关性

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    袁海鹏; 李福康; 李改芹; 王晓虹; 李晓沛; 李延青

    2012-01-01

    目的 探讨精神心理因素和十二指肠黏膜肥大细胞(mast cell,MC)在功能性消化不良(functional dyspepsia,FD)中的作用.方法 应用医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)评定焦虑(HADS-A)和抑郁积分(HADS-D),甲苯胺蓝染色计数十二指肠黏膜MC总教及脱颗粒比率.直线相关分析HADS-A、HADS-D与十二指肠黏膜MC的相关性.结果 FD患者HADS-A和HADS-D显著高于对照组(P<0.05),十二指肠黏膜MC显著高于对照组(P<0.01),MC脱颗粒比率显著高于对照组(P<0.001).HADS-A、HADS-D与十二指肠MC计数、脱颗粒比率呈正相关(P<0.05).结论 FD患者的精神心理异常,可能与十二指肠黏膜MC的数目及脱颗粒比率增高有关.%Objective To explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of functional dyspepsia (FD). Methods The Hospital Anxiety and Depression Scale (HADS) was used to evaluate the psychosocial status of FD patients. Mast cell abundance and degranulation rates in the bulb (D1) and second part (D2) of the duodenum were obtained on toluidine blue-stained sections. The relationships among the scores of anxiety (HADS-A) and depression (HADS-D), the MC counts and MC degranulation rates in Dl and D2 were studied. Results HADS-A and HADS-D scores were significantly higher in FD patients than in controls (P <0.05). This was also true for duodenal mast cell abundance (P < 0.01) and degranulation rates (P < 0. 001). Scores of HADS-A and HADS-D were positively correlated with the duodenal mast cell abundance and degranulation rates. Conclusion The abnormal psychosocial status of FD patients is correlated with the increased abundance and degranulation rates of duodenal mast cells.

  1. Clinical observation of coordinated treatment of psychological language, acupuncture point stimulation and gastric pacing on refractory functional dyspepsia%心理语言、穴位刺激和胃电起搏协同治疗难治性功能性消化不良

    Institute of Scientific and Technical Information of China (English)

    陈英; 张洪领; 杨春敏; 杜斌; 范勤; 唐合兰; 韩全力; 李静; 贾敏; 于妍

    2012-01-01

    目的 研究心理语言、穴位刺激、胃电起搏同步协同治疗方法(coordinated treatment of psychological language,acupuncture point stimulation and gastric pacing,CTPAG)治疗难治性功能性消化不良的临床疗效.方法 根据罗马Ⅲ标准选取80例难治性功能性消化不良患者,随机分为两组:口服药物组(n=38)和CTPAG组(n=42),比较两组受试者在症状评分、焦虑评分、抑郁评分中的差异.结果 与口服药物组比较,CTPAG组临床症状评分明显下降,疗效显著率明显升高;焦虑、抑郁评分也明显下降,差异具有统计学意义(P<0.05).结论 心理语言、穴位刺激和胃电起搏协同治疗难治性功能性消化不良疗效优于常规口服药物,是功能性消化不良非药物治疗的一种新选择.%Objective To investigate a new method for treating refractory functional dyspepsia ( FD) with coordinated treatment of psychological language, acupuncture point stimulation and gastric pacing (CTPAG). Methods Eighty refractory FD patients were selected according to the Rome III criteria. These patients were randomly divided into oral application group (n =38) and CTPAG group (n =42). The scores of clinical symptom, anxiety and depression were e-valuated and analyzed. Results Compared with the oral application group, the scores of clinical symptom were descended , the ratios of therapeutic effect were elevated, and the scores of anxiety and depression were also descended in CTPAG group (P <0. 05 ). Conclusion CTPAG, a new non-drug method for treating refractory functional dyspepsia is effective and reliable. The curative effect surpasses the traditionary method of oral application.

  2. 心理语言、穴位刺激和胃电起搏协同改善功能性消化不良的胃感觉功能%Coordinated treatment of psychological language, acupuncture point stimulation and gastric pacing on functional dyspepsia by improving gastric sensory function

    Institute of Scientific and Technical Information of China (English)

    陈英; 张洪领; 杨春敏; 颜伟; 杜斌; 唐合兰; 范勤; 韩全力; 李静; 贾敏

    2012-01-01

    目的 研究心理语言、穴位刺激、胃电起搏协同治疗方法(Coordinated Treatment of Psychological language,Acupuncture point stimulation and Gastric pacing,CTPAG)治疗难治性功能性消化不良的临床疗效及可能机制.方法 根据罗马Ⅲ标准选取80例难治性功能性消化不良患者,随机分为两组:口服药物组(n=38)和CTPAG组(n=42),比较两组受试者在症状评分、临床疗效、胃感觉功能中的差异.结果 与口服药物组比较,CTPAG组中临床症状评分明显下降,疗效显著率明显升高;胃的初次饱足阈值和最大耐受阈值均明显增加,差异具有统计学意义(P<0.05).结论 心理语言、穴位刺激和胃电起搏协同治疗(CTPAG)可能通过增加胃的可耐受容积,降低内脏敏感性,达到改善早饱、腹胀、进食少等疗效;并且CTPAG组优于常规口服药物组,是难治性FD非药物治疗的一种新选择.%Objective To investigate a new method for treating intractable functional dyspepsia (FD) with Coordinated Treatment of Psychological language, Acupuncture point stimulation and Gastric pacing ( CTPAG). Methods Eighty intractable FD patients were selected according to the Rome III criteria. Two groups were separated randomly o o-ral application group ( n = 38 ) and CTPAG group ( n = 42). The scores of clinical symptom, therapeutic effect and gastric sensory function were all evaluated and analyzed. Results In the CTPAG group, the scores of clinical symptom were descended, the ratios of therapeutic effect were elevated, and the satiation threshold values were also elevated compared with the oral application group (P < 0.05). Conclusion CTPAG, a new choice for treating intractable functional dyspepsia is effective and reliable. The curative effect surpasses the traditionary method of oral application. CTPAG may increase gastric tolerant volume, decrease visceral sensitivity and achieve to improve the symptoms such as early full, abdominal distension

  3. Eeffect of Chaishaoweiyan granules on the secretion of gastrin and motilin in rats with functional dyspepsia%柴芍胃炎颗粒对功能性消化不良模型大鼠血浆胃动素与胃泌素的影响

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    赵龙; 喻玉; 李丽; 杨伟兴; 陈辉; 刘蔚; 向未; 肖国辉

    2013-01-01

    目的:通过观察柴芍胃炎颗粒对功能性消化不良(functional dyspepsia,FD)模型大鼠血浆胃动素、胃泌素的影响,探讨该药治疗功能性消化不良的可能机制。方法:将FD模型大鼠按随机化原则分为模型组,多潘立酮组,柴芍胃炎颗粒高、中、低组,同时与空白组比较,观察各组大鼠饮水、饮食、体重变化和胃排空率,用ELISA法测定血浆胃泌素(gastrin,GAS)、胃动素(motilin,MTL)。结果:胃泌素:各中药组、多潘立酮组较空白组明显升高(P0.05);胃动素:中药高剂量组、中剂量组与正常空白组间无明显差异(P>0.05),但较中药低剂量组及多潘立酮组升高(P 0.05).No significant difference was noted in motilin among the normal control group, medium-and high-dose CSWY granules groups(P > 0.05). However, the motilin in the former three groups were higher than that in domperidone group and low-dose CSWY granules group (P< 0.05).The gastric emptying rates in normal control group, medium- and high-dose CSWY granules groups were higher than in low-dose CSWY granules group (P<0.05),but lower than in domperidone group (P< 0.05). Conclusion: CSWY Granules may relieve gastric dynamic dysfunction in rats with functional dyspepsia (FD) by increasing the levels of plasma gastrin and motilin, and improving gastric emptying rate. It is worth to notice that the paranormal motilin and gastric emptying rate are not good for digestion and absorption.

  4. The observation on the effect of Simo decoction combined with Jinshuangqi for functional dyspepsia in children%四磨汤口服液联合金双岐治疗小儿功能性消化不良疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨武萍

    2015-01-01

    目的:观察四磨汤口服液联合金双岐治疗小儿功能性消化不良的临床效果、安全性及停药后的复发率。方法:将92例临床诊断为功能性消化不良的小儿分为治疗组(52例)和对照组(40例),治疗组采用四磨汤口服液联合金双岐,口服2周,对照组给予胃蛋白酶颗粒口服2周,疗程结束后比较两组患儿的临床疗效,观察用药期间的不良反应,结束治疗1个月后统计两组患儿的复发率。结果:治疗组疗程结束后食欲改善、食量增加明显好于对照组,有效率78.8%,对照组有效率57.5%,两组比较差异有统计学意义(P ﹤0.05);两组患儿治疗期间均未见明显不良反应,结束治疗1个月后治疗组复发8例,复发率19.5%,对照组复发11例,复发率47.8%,,两组比较差异有统计学意义(P ﹤0.05)。结论:四磨汤口服液联合金双岐治疗小儿功能性消化不良显效快、疗效好、安全、无不良反应、复发率低。%Objective:To observe the clinical effect of Simotang oral liquid combined with Jinshuangqi,treatment of chil-dren with functional dyspepsia observe the effect of Simo decoction combined with clinical effect,safety of Jinshuangqi in trea-ting children with functional dyspepsia and the relapse rate after stopping. Methods:The clinical diagnosis for 92 cases of func-tional dyspepsia in children divided into treatment group of 52 cases,with Simotang oral liquid combined with Jinshuangqi oral-ly for 2 weeks,the control group of 40 patients with pepsin granules orally for 2 weeks,the clinical efficacy of the two groups of children before and after treatment,adverse effects were observed during the treatment,1 months after the end of treatment of two groups of children with recurrent rate statistics. Results:The end of the treatment group after treatment improved appetite, food intake increased significantly better than the control group

  5. Evaluation of small intestine bacterial overgrowth in patients with functional dyspepsia through H2 breath test Avaliação de supercrescimento bacteriano no intestino delgado em pacientes com dispepsia funcional, utilizando o teste de H2 no ar expirado

    Directory of Open Access Journals (Sweden)

    Michelle Bafutto Gomes Costa

    2012-12-01

    Full Text Available CONTEXT: Functional dyspepsia is a condition in which symptoms are not related to organic underlying disease; its pathogenesis is not well known. The small intestinal bacterial overgrowth (SIBO is characterized by the increase in the number and/or type of colonic bacteria in the upper gastrointestinal tract. The hypothesis of SIBO being associated to functional dyspepsia must be considered, since the impaired motility of the gastrointestinal tract is one of the main etiologic factors involved on both pathologies. OBJECTIVE: To determine if there is SIBO in patients with functional dyspepsia. METHODS: Case-control study, evaluating 34 patients: 23 functional dyspeptic and 11 non-dyspeptic (control group. Questionnaire applied based on Rome III criteria. The patients underwent H2-lactulose breath test, considered positive when: H2 peak exceeding 20 ppm, in relation to fasting, or two peaks exceeding 10 ppm sustained until 60 minutes. RESULTS: Of the 23 dyspeptic patients, 13 (56.5% obtained positive results for SIBO trough the H2-lactulose breath test. On control group, SIBO was not observed. The association between the dyspeptic group and the control group regarding SIBO was statistically significant, with P = 0.0052. In the group of dyspeptic patients, 12 (52.2% were using proton pump inhibitor; of these 9 (75% were positive for SIBO. In the control group, none of the 11 patients used proton pump inhibitors and SIBO was not observed. The association of the dyspeptic group using proton pump inhibitor that were positive for SIBO and the control group was statistically significant, with P = 0.0011. CONCLUSION: It was found that, patients with functional dyspepsia presented SIBO, when they underwent to H2-lactulose breath test, compared to the non-dyspeptic. In addition, it was observed a higher prevalence of SIBO in dyspeptic patients that were using proton pump inhibitors, compared to control group.CONTEXTO: A dispepsia funcional é uma afec

  6. 心理语言协同胃电起搏治疗功能性消化不良30例%Psychological language combined with gastric pacing for treatment of functional dyspepsia: An analysis of 30 cases

    Institute of Scientific and Technical Information of China (English)

    邵颖锬; 杨春敏; 陈英; 杜斌; 李静; 韩全利; 唐合兰; 葛淑静; 陈璐; 贾敏

    2013-01-01

    较对照组亦明显增高(90.0% vs80.0%,x2=1.18,P<0.05).结论:心理语言结合胃电起搏协同强化治疗功能性消化不良疗效优于单纯胃电治疗对照组,是非药物治疗功能性消化不良的一种新选择,也提示了心理调试在治疗功能性消化不良方面的必要性.%AIM: To assess the efficacy of psychological language combined with gastric pacing (GP) for treating functional dyspepsia (FD). METHODS: Sixty patients with FD diagnosed according to the Rome III criteria were randomly divided into a combination treatment group (n = 30) and a GP group (n = 30). All patients were placed in a quiet environment. The combination treatment group received psychological language and gastric pacing synchronization output, and the voice ran throughout the treatment to guide gastric electrical pacing. The GP group underwent GP only. The treatment (20 min each) was given once daily for seven consecutive days. Researcher-rated symptom scores and patients' self-rated symptom scores (both overall and individual symptom scores) were calculated to assess clinical efficacy before and after treatment. Clinical efficacy was compared between the two groups of subjects. RESULTS: Researcher-rated symptom scores and patients' self-rated symptom scores decreased in both groups after treatment. Compared to the GP group, the combination treatment group had more significantly decreased researcher-rated overall symptom score (4.033 ± 1.903 vs 1.700 ± 1.579, t = 5.169, P < 0.05), postprandial bloating (0.967 ± 0.850 vs 0.533 ± 0.776, t = 2.062, P < 0.05), early satiety (0.933 ± 0.785 vs 0.300 ± 0.466, t = 3.800, P < 0.05), upper abdominal pain (0.900 ± 0.759 vs 0.400 ± 0.563, t= 2.898, P < 0.05), abdominal burning sensation (0.700 ± 0.702 vs 0.300 ± 0.535, t = 2.482, P < 0.05), and nausea (0.533 ± 0.776 vs 0.200 ± 0.407, t = 2.482, P < 0.05), scores. The overall response was significantly higher in the combination treatment group than in the GP group (96.7% vs 70.0%, x2

  7. Risk of dyspepsia and anorexia due to glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus:a Network Meta-analysis%胰高血糖素样肽1受体激动剂类降糖药致2型糖尿病患者消化不良和厌食发生风险的Network Meta分析

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    李志霞; 曾宪涛; 柴三葆; 全晓驰; 武珊珊; 杨智荣; 詹思延; 孙凤

    2015-01-01

    Objective To evaluate the risk of dyspepsia and anorexia due to glucagon-like peptide-1 receptor agonist(GLP-1 RA)in patients with type 2 diabetes mellitus(T2DM). Methods The electronic database of Chinese BioMedical Literature Database( CBMdisc ), Chinese Medical Current Contents( CMCC),Medline,EMbase,the Cochrane Library and web site of ClinicalTrials. gov were searched from inception to May 1st 2014. Those randomized controlled trials whose inclusion criteria including patients with T2DM as the research object,comparisons of GLP-1 RA and placebo or other conventional anti-diabetic drugs as the intervention measures,and dyspepsia and anorexia as the outcomes were collected. A traditional Meta-analysis and a Network Meta-analysis were used and relational graph and rank ordering figure of all the intervention measures were drawn. Results A total of 42 randomized controlled trials were enrolled into this study involving 20 916 patients with T2DM and 13 kinds of intervention measures comprised 7 kinds of GLP-1 RAs( exenatide,exenatide release agent,liraglutide, lixisenatide,taspoglutide, albiglutide, and dulaglutide ), 5 kinds of conventional anti-diabetic drugs ( insulin, metformin, sulfonylureas, sitagliptin, and thiazolidinediones ketones ), and placebo. The traditional Meta-analysis showed that,compared with placebo,the whole of GLP-1 RAs could increase the risks of dyspepsia[odds ratio(OR)=3. 04,95% confidence interval(CI):1. 79-5. 16]and anorexia (OR=2. 57,95%CI:1. 69-3. 91)and there were statistically significant differences(P 1. 00 except for lixisenatide versus sitagliptin )and,of them,dulaglutide was at the greatest risk,48. 91,16. 65,36. 24,and 4. 75 times as high as that of insulin,sulfonylureas,thiazolidinediones ketones,and sitagliptin,respectively. There was no statistically significant difference between two kinds of GLP-1 RAs for risks of dyspepsia and anorexia( all P>0. 05). The risks of dyspepsia and anorexia due to the 13 kinds of intervention

  8. Assessment of Anxiety and Depression by Three Psychological Screening Scales in Functional Dyspepsia Patients%三种不同心理测评量表对功能性消化不良患者焦虑、抑郁状态的评估

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    刘芳宜; 朱丽明; 方秀才; 常敏; 陈卫; 王智凤; 史丽丽; 徐涛

    2012-01-01

    功能性消化不良(FD)与精神心理因素密切相关,客观评估FD患者的心理状态对理解消化不良症状产生的机制、指导选择综合治疗方案、客观评估疗效均具有重要意义.目的:比较汉密尔顿焦虑/抑郁量表(HAMA/HAMD)、Zung焦虑/抑郁自评量表(SAS/SDS)和罗马Ⅲ心理社会警报问卷(RPAQ)对FD患者焦虑、抑郁状态的检出一致性.方法:纳入2008年11月~2010年4月北京协和医院符合罗马Ⅲ诊断标准的FD患者,同时接受HAMA、HAMD他评以及SAS、SDS和RPAQ自评.结果:共纳入134例FD患者.HAMA对FD患者焦虑检出率为72.4%,明显高于SAS(24.6%)和RPAQ(31.3%) (P<0.05);HAMD对FD患者抑郁检出率为47.0%,与SDS无明显差异(44.O%,P>0.05),但明显高于RPAQ(20.9%,P<0.05).SDS与HAMD检出结果的总符合率为73.1%.HAMA/HAMD较SAS/SDS、RPAQ更易检出重度FD患者合并的焦虑和抑郁;SAS和RPAQ漏检约半数FD患者合并的中重度焦虑.结论:HAMA/HAMD较SAS/SDS、RPAQ更易发现FD患者合并的焦虑、抑郁状态,其检出率差异可能与量表不同的构成有关.%Psychological disorders are common in patients with functional dyspepsia (FD). It is important to assess the abnormal psychological status in patients with FD for understanding the mechanism of dyspepsia symptoms, guidance of therapy and assessment of efficacy. Aims: To compare the consistency of Hamilton anxiety/depression scale (HAMA/HAMD), self-rating anxiety/depression scale (SAS/SDS) and Rome III psychosocial alarm questionnaire (RPAQ) as screening tools for detection of anxiety/depression in FD patients. Methods: Patients met Rome III diagnostic criteria of FD from Nov. 2008 to Apr. 2010 at Peking Union Medical College Hospital were enrolled. HAMA and HAMD were assessed by a well trained physician, SAS, SDS and RPAQ were completed by patients themselves following the instruction. Results: A total of 134 patients with FD were enrolled in this study. The

  9. 利用气质联用方法研究功能性消化不良患者血浆代谢谱的变化%Metabolic changes in plasma of patients with functional dyspepsia using GC-MS

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    刘娟; 吴巧凤; 孙博; 周思远; 余曙光; 董方霆; 颜贤忠

    2011-01-01

    Objective To investigate the characteristics of plasma metabolites in functional dyspepsia ( FD ). Methods Gas chromatography/time-of-flight mass spectrometry ( GC/TOF-MS )-based metabonomics was applied to compare the plasma metabolic difference between FD female patients ( n = 16 ) and normal female subjects ( n = 14 ). The integral data were subject to partial least squares-discriminant analysis ( PLS-DA ) through SIMCA-P1O. 0 software. Results Using GC/TOFMS technique , a total of 122 chromatographic peaks were detected,35 of which were identified as endogenous metabolites.Multivariate statistical analysis showed significant changes in FD plasma metabolites, such as those of urea, glycine , phenylalanine, valine, linoleic acid, cholesterol compared to healthy controls. Analysis of metabolic pathway found that FD female patients had a higher level of energy metabolism than controls. Besides, metabolism of amino acids, fatty acids and intestinal flora were affected in FD female patients. Conclusion The metabonomic approach can evaluate the level of plasma metabolites in FD patients. This new method may he of great benefit to the pathogenesis research of FD.%目的 采用基于气质联用的代谢组学技术研究功能性消化不良(functional dyspepsia,FD)患者血浆中小分子代谢物的变化.方法 采集FD女性患者血浆样本16例及正常女性14例,经气相色谱-飞行时间质谱(gas chromatography / time-of-flight mass spectrometry,GC/TOF-MS)联用检测后,应用SIMCA-P10.0软件对积分数据进行偏最小二乘法-辨别分析(partial least squares-discriminant analysis,PLS-DA).结果 GC/TOF-MS共检测得到色谱峰122个,其中鉴定出代谢产物31个.统计分析结果显示,与正常人相比,FD女性患者血浆中尿素、甘氨酸、苯丙氨酸、缬氨酸、磷酸、亚油酸、胆固醇等代谢物含量发生了明显变化.结合代谢途径分析发现,FD患者体内的能量代谢升高,而且患者体内氨基酸、脂

  10. 胃痛消痞方对功能性消化不良大鼠血清及胃组织中Ghrelin、Leptin的影响%Influence of Weitongxiaopi Decoction on serum and gastric ghrelin and leptin in rats with functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    陈苏宁; 礼海; 史业东

    2010-01-01

    目的:探讨胃痛消痞方对功能性消化不良(functional dyspepsia,FD)肝郁脾虚型大鼠血清及胃组织中Ghrelin、Leptin含量的影响.方法:通过改良夹尾刺激法建立FD大鼠模型,胃痛消痞方(中药)组与西沙必利(西药)组灌服相应药物3 wk.模型组和对照组进行对照观察.利用ELISA、Western blot检测血清与胃组织中Ghrelin与Leptin的含量.结果:利用ELISA检测Ghrelin、Leptin含量.中药组中Ghrelin含量显著高于西药组(132.7mg/L±10.78 mg/L vs 103.17 mg/L±13.46 mg/L,P<0.01);中药组中Leptin含量显著低于西药组(31.30 mg/L±5.81 mg/L vs 37.55 mg/L±4.32mg/L.P<0.01).Western blot检测Ghrelin、Leptin蛋白表达水平,中药组中Ghrelin蛋白表达水平显著高于西药组(150.87±12.76 vs 118.97±8.93,P<0.01);中药组中Leptin蛋白表达水平显著低于西药组(60.28±9.28 vs 67.75±5.67,P<0.01).结论:胃痛消痞方可以提高血清及胃组织蛋白中Ghrelin含量,降低Leptin含量.

  11. Influence of hippophae rhamnoides on neuropeptide Y,gastric emptying and body fat in children with func-tional dyspepsia%沙棘对功能性消化不良患儿神经肽 Y、胃动力及体脂的影响

    Institute of Scientific and Technical Information of China (English)

    肖满田; 丘小汕; 蔡泳仪

    2014-01-01

    目的:探讨沙棘对功能性消化不良( FD)患儿食欲因子神经肽Y( NPY)水平及其胃动力、体脂的影响。方法选择符合FD诊断标准的患儿120例,采用单纯随机抽样方法分为三组,Ⅰ组单纯予以沙棘干乳剂治疗,Ⅱ组予以多潘立酮治疗,Ⅲ组予以沙棘干乳剂加多潘立酮治疗,共8周,治疗前后分别测血浆NPY水平,并采用B超检查作胃液体排空试验测餐后30 min、60 min、90 min和120 min的胃窦残留率,测量患儿皮下脂肪平均值、体脂比、上臂围、体质量、身高。结果Ⅰ组、Ⅱ组、Ⅲ组血浆食欲因子NPY水平治疗前分别是(107.52±24.12)ng/L、(114.63±17.95)ng/L和(114.56±25.10)ng/L,差异无统计学意义(F=1.307, P>0.05);经治疗后,三组血浆NPY分别是(137.38±29.86) ng/L、(121.43±13.78) ng/L和(149.27±31.9) ng/L,差异有统计学意义(F=11.23,P<0.05);Ⅰ组、Ⅲ组NPY水平治疗后明显高于治疗前(t=4.95、5.40,均P<0.05)。Ⅰ组、Ⅲ组餐后60 min、90 min和120 min的胃窦残留率比Ⅱ组同期均明显减少( F=4.93、6.40、4.61,P<0.05);Ⅰ组、Ⅲ组皮下脂肪平均值﹑体脂比、上臂围、体质量增加值显著高于Ⅱ组( F=16.80、46.9、21.06、12.08,均P<0.05)。而Ⅰ组与Ⅲ组两组治疗后食欲因子NPY水平、胃窦残留率及皮下脂肪平均值﹑体脂比、上臂围、体质量比较,差异均无统计学意义(均P<0.05)。结论沙棘对FD患儿食欲因子NPY有明显调节作用,促进胃排空,同时患儿体脂明显增加,体格发育明显改善。%Objective To explore the effect of hippophae rhamnoides on the level of plasma appetite factors neuropeptide Y ,the gastric motility and on their body fat in children with functional dyspepsia .Methods A hundred and twenty children with functional dyspepsia were

  12. 多潘立酮混悬液联合多酶片治疗小儿功能性消化不良的临床效果观察%The clinical observation and analysis of domperidone oral liquid combined with multienzyme tablets for the treatment of pediatric functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    沈春荣

    2015-01-01

    Objective To explore the effect of domperidone oral liquid combined with multienzyme tablets for the treatment of functional dyspepsia.Methods 150 children with functional dyspepsia were selected,they were randomly divided into the observation group and control group by using the random number table method,with 75 ca-ses each group.The control group received domperidone oral liquid treatment and the observation group were given domperidone oral liquid combined with multienzyme tablets treatment.The main clinical symptom score and improve-ment time of two groups,and assess the adverse reactions were observed.Results The satiety,loss of appetite, abdominal discomfort,nausea and vomiting and fecal condition score of the observation group after treatment were (0.48 ±0.13),(0.53 ±0.22),(0.21 ±0.18),(0.79 ±0.38),(0.28 ±0.19),which were lower than the control group after treatment (t =8.46,9.27,7.94,10.11,8.04,all P 0.05).Conclusion There was better effect on domperidone oral liquid combined with multienzyme tablets on func-tional dyspepsia in children,which could improve the patient's clinical symptoms or signs significantly.And could in-duce the improvement time.%目的:探讨多潘立酮混悬液联合多酶片治疗小儿功能性消化不良的临床效果。方法选择功能性消化不良患儿150例,采用随机数字表法将患儿分为观察组和对照组各75例。对照组给予多潘立酮混悬液治疗;观察组给予多潘立酮混悬液联合多酶片治疗。观察两组主要临床症状评分、症状改善时间及不良反应。结果观察组治疗后饱胀感、食欲减退、腹部不适、恶心呕吐和大便状况评分分别为(0.48±0.13)分、(0.53±0.22)分、(0.21±0.18)分、(0.79±0.38)分和(0.28±0.19)分,均低于对照组治疗后(t =8.46、9.27、7.94、10.11、8.04,均 P <0.05)。观察组治疗后总疗程、腹胀、恶心呕吐、食欲减退、大便正

  13. The curative effect of combizym combined with esomeprazole in the treatment of gastroesophageal reflux disease with dyspepsia%米曲菌胰酶联合埃索美拉唑治疗胃食管反流病伴消化不良的疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈斌鸣; 陈素钻; 荆绪斌; 郭光华

    2015-01-01

    目的 观察米曲菌胰酶联合埃索美拉唑治疗胃食管反流病伴消化不良的疗效.方法 133例胃食管反流病伴消化不良的患者采用抽签法随机分为两组,A组给予埃索美拉唑每次20 mg、每天1次+米曲菌胰酶片每次1粒、每天3次口服治疗,B组给予埃索美拉唑每次20 mg、每天1次口服治疗,分别于2周和4周后对比两组的症状积分、疗效评估和药物不良反应.结果 治疗2周后A组腹胀、早饱较B组改善(腹胀x2 =4.516,P=0.038;早饱x2=4.630,P=0.041),治疗4周后A组腹胀、早饱、稀便较B组改善(腹胀x2=5.317,P=0.025;早饱x2=5.036,P=0.027;稀便x2=4.989,P=0.030),余症状改善不明显(P>0.05).治疗2周、4周后A组与B组总有效率分别为85.2%与68.1%(x2=8.917,P=0.030)、93.4%与69.4%(x2=17.526,P=0.001),A组总体疗效均高于B组.治疗2周和4周后A组症状积分较B组均明显降低(2周t=6.355,P=0.000;4周t=5.450,P=0.000),总有效率明显提高.两组均未发现严重不良反应.结论 米曲菌胰酶联合埃索美拉唑能更好改善胃食管反流病伴消化不良的症状,没有明显不良反应.%Objective To investigate the curative effect of Oryz-Aspergillus Enzyme and Pancreatin Tablet (Combizym) combined with esomeprazole Magnesium Enteric-coated Tables (Esomeprazole) in the treatment of gastroesophageal reflux disease with dyspepsia.Methods 133 patients with gastroesophageal reflux disease and dyspepsia symptoms were randomly divided into two groups.Group A received esomeprazole 20mg once a day and Combizym 1 pill three times a day,while group B only received esomeprazole 20mg once a day.The symptoms integral,curative effect and adverse reaction in the two groups after treatment for 2 weeks and 4 weeks were compared.Results Compared with group B,the symptoms of abdominal distension and satiety significantly relieved after 2 weeks treatment in group A (abdominal distension x2 =4.516,P =0.038 ;satiety x2 =4.630,P =0.041),and one

  14. Evaluation of Helicobacter pylory colonization by serologic test (IgG and dyspepsia in volunteers from the countryside of Monte Negro, in the Brazilian western Amazon region Avaliação da colonização por Helicobacter pylori através de teste sorológico (IgG e de dispepsia em voluntários da população rural de Monte Negro (RO, região da Amazônia ocidental

    Directory of Open Access Journals (Sweden)

    Rafael Bernardon Ribeiro

    2010-08-01

    Full Text Available The present study intended to analyze the seroprevalence of Helicobacter pylori, IgG, and its relation to dyspepsia in a population from the western Amazon region. During the "Projeto Bandeira Científica", a University of São Paulo Medical School program, in Monte Negro's rural areas, state of Rondônia, 266 blood samples were collected from volunteers. The material was tested for IgG antibodies anti-Helicobacter pylori by ELISA method and the participants were also interviewed on dyspepsia, hygiene and social aspects. Participants aged between five and 81 years old (34 years on average, 149 (56% were female and 117 (44% male. We found 210 (78.9% positive, 50 (18.8% negative and six (2.3% undetermined samples. Dyspeptic complaints were found in 226 cases (85.2%. There was no statistical association between dyspepsia and positive serology for H. pylori. We concluded that the seroprevalence in all age categories is similar to results found in other studies conducted in developing countries, including those from Brazil. On the other hand, the seroprevalence found in Monte Negro was higher than that reported in developed countries. As expected, there was a progressive increase in the positivity for H. pylori in older age groups.Este trabalho tem por objetivo analisar a soroprevalência do Helicobacter pylori, IgG, em população rural da Amazônia, e sua correlação com queixa dispéptica. No Projeto Bandeira Científica da FMUSP, em Monte Negro - RO, foram coletadas 266 amostras sangüíneas nos assentamentos rurais do município. Foram pesquisados anticorpos da classe IgG dirigidos contra Helicobacter pylori pelo método ELISA e aplicados questionários sobre dispepsia, aspectos sociais e epidemiológicos. Os pacientes tinham idades entre cinco e 81 anos (média de 34 anos; 149 (56% do sexo feminino e 117 (44% do sexo masculino. Foram encontradas 210 (78.9% amostras positivas, 50 negativas (18.8% e seis indeterminadas (2.3%. A queixa de

  15. 重庆市公务员功能性消化不良患者健康相关生命质量研究%Study on the health related quality of life in civil servants with functional dyspepsia in Chongqing

    Institute of Scientific and Technical Information of China (English)

    戴若以; 顾小红

    2016-01-01

    目的 分析重庆市公务员功能性消化不良(functional dyspepsia,FD)患者抑郁状况和健康相关生命质量(health related quality of life,HRQOL)结果,并研究患者健康相关生命质量的影响因素.方法 选取同期参加体检的公务员831名、个体经营者925名,以公务员FD患者(208例)作为试验组,以个体经营FD患者(204例)作为对照组,使用抑郁自评量表(self-rating depression scale,SDS)评估抑郁状况,使用生活质量评价量表(short form 36 questionnaire,SF-36)测量HRQOL分数,并使用单因素方差分析和多元逐步线性回归统计方法对公务员FD患者HRQOL的影响因素进行分析.结果 公务员FD患者HRQOL总分低于个体经营FD患者(t=2.95,P=0.00),SDS评分高于个体经营FD患者(t=3.03,P=0.00).统计结果显示,SDS评分、辛辣饮食、年龄、性别、治疗处理、文化程度、行政级别、锻炼、吸烟、饮酒可影响公务员FD患者HRQOL评分.结论 重庆市公务员FD患病率较高,心理健康水平和生命质量均低于个体经营者.重视中老年、高学历、高行政级别者和女性的防治、戒除辛辣饮食、戒烟、戒酒、对症药物治疗、加强锻炼、心理疏导可以改善患者健康相关生命质量.

  16. 中药结合穴位埋线治疗功能性消化不良伴焦虑抑郁状态患者的疗效观察%Clinical observation of effects of thread-embedding therapy combined with traditional Chinese medicine in treatment of functional dyspepsia accompanied by anxiety and depression

    Institute of Scientific and Technical Information of China (English)

    刘宸睿; 刘凤斌

    2016-01-01

    Objective:To observe clinical therapeutic effects of thread-embedding therapy combined with traditional Chinese medicine ( TCM) in treatment of functional dyspepsia ( FD) accompanied by anxiety and depression. Methods:60 patients with FD accompanied by anxiety and depression were selected and randomly divided into treatment group ( thread-embedding therapy combined with TCM) and control group ( the monotherapy of TCM) , with 30 patients in each group. The treatments lasted for 4 weeks, then these patients were evaluated with the self-rating depression scale ( SDS) , self-rating anxiety scale SAS and the Clinician-deported outcome ( CRO) scale before and after the treatment, and the results of the two groups were compared. Results:After the treatment, the total effective rates of treatment group and control group were 96. 67% and 90%, respectively, and the difference between the two groups was statistically significant (P0. 05). Conclusions:Thethread-embed-ding therapy combined with TCM in the treatment of FD accompanied by anxiety and depression is superior to single TCM.%目的::观察中药结合穴位埋线疗法治疗功能性消化不良伴焦虑、抑郁状态患者的疗效。方法:选择功能性消化不良伴焦虑抑郁状态患者60例,随机分为治疗组和对照组,每组各30例。治疗组患者给予穴位埋线加中药治疗;对照组患者给予单纯中药治疗。两组患者均经过4周的治疗。治疗前后,采用焦虑自评量表( SAS)、抑郁自评量表( SDS)量表和医生报告结局量表( Clinician-deported outcomes,CRO)对两组患者进行评定,并进行比较。结果:治疗后,治疗组患者的总有效率96.67%;对照组总有效率90%,组间差异有统计学意义(P0.05)。结论:中药结合穴位埋线治疗功能性消化不良伴焦虑抑郁状态患者的疗效优于单纯中药治疗。

  17. 心理干预改善功能性消化不良患者焦虑、抑郁状态的效果观察%Effect Observation of Mental Intervention in Improvement of Anxiety and Depressive State of Patients with Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    苏江华; 刘冰; 冯红; 王彦民; 杨晓锋

    2013-01-01

    目的 探讨心理干预改善功能性消化不良(functional dyspepsia,FD)患者焦虑、抑郁状态的临床效果.方法 选择2007年10月-2008年3月在我院住院并确诊的FD 45例,随机分为观察组(21例)和对照组(24例).观察组在常规治疗基础上同时实施心理干预,对照组仅进行常规治疗.两组皆于治疗前后采用Zung抑郁自评量表(SDS)、Zung焦虑自评量表(SAS)进行焦虑、抑郁症状评估,健康调查简表(SF-36)综合评价生存质量,并进行比较.结果 治疗前两组SDS、SAS和SF-36评分比较差异均无统计学意义(P>0.05).治疗后两组焦虑、抑郁症状评分均较治疗前显著下降,差异有统计学意义(P<0.05),生存质量各方面评分均较治疗前显著增加,差异亦有统计学意义(P<0.01).治疗后观察组焦虑、抑郁症状评分均低于对照组,差异有统计学意义(P<0.05);生存质量评分中,RP和RE评分亦均低于对照组,差异亦有统计学意义(P<0.05).结论 对FD患者实施健康教育、认知-行为疗法及音乐疗法3种方法相结合的心理干预,可明显改善焦虑、抑郁状态,并可使生存质量得到一定程度改善.%Objective To explore clinical effect of mental intervention in improvement of anxiety and depressive state of patients with functional dyspepsia (FD). Methods A total of 45 patients with FD during October 2007 and March 2008 in our hospital were randomly divided into therapy group (n =21) and control group (n =24). The therapy group was given mental intervention on the basis of conventional therapy, while the control group was only given conventional therapy. The anxiety and depressive state of the two groups were evaluated with Zung self-rating depression scale ( SDS) and Zung self-rating anxiety scale (SAS) before and after the treatment. The quality of life in two groups were evaluated with SF-36 and were also compared. Results The differences of SDS, SAS and SF-36 were not statistically

  18. Effects of the Drug Pair of Coptidis Rhizoma and Zingiberis Rhizoma on Gastric Emptying and Serum Gastrin in Rats with Functional Dyspepsia%黄连干姜药对对功能性消化不良大鼠胃排空和血清胃泌素的影响

    Institute of Scientific and Technical Information of China (English)

    史琪荣; 于少云; 孙晓迪; 闫荟; 孙世光; 谢予朋; 张京

    2011-01-01

    OBJECTIVE To study the combination laws of drug pair of rhizoma coptidis-zingiberis. METHODS Functional dyspepsia models were induced by stimulating rats on tails with forceps clip. In the experiment,wistar rats were divided into ten groups, namely,normal control group,model group,motilium group,coptidis rhizoma group,zingiberis rhizoma group,drug pair I group (coptidis rhizoma - zingiberis rhizoma = 1:3), drug pair II group (coptidis rhizome- zingiberis rhizoma = 1:1), drug pair III group (coptidis rhi-zoma-zingiberis rhizoma = 3:1), polar constituents of zingiberis rhizoma group, essential oil of zingiberis rhizoma group, and were given orally corresponding materials. Relative residue rate of gastric pigment,percentage of intestinal propulsion and serum gastrin in all the groups were detected after 7 d treatment RESULTS Compared with model group,relative residue rate of gastric pigment decreased significantly in polar constituents of zingiberis rhizoma group and essential oil of zingiberis rhizome group ( P < 0. 05), relative residue rate of gastric pigment increased significantly in coptidis rhizoma group (P < 0.05 ). Percentage of intestinal propulsion increased significantly in coptidis rhizoma group,zingiberis rhizoma group,drug pair I group,drug pair II group,drug pair III group,polar constituents of zingiberis rhizoma group and essential oil ai zingiberis rhizoma group ( P < 0. 05, P < 0. 01). The content of serum gastin decreased significantly in essential oil of zingiberis rhizoma group (P <0. 01). CONCLUSION It could be inferred that coptidis rhizoma could inhibite gastric emptying significantly,and promote intentional propulsion significantly. The different polar parts of zingiberis rhizoma could promote both gastric emptying and intentional propulsion significantly. Drug pairs of different proportion of coptidis rhizoma and zingiberis rhizoma could promote intentional propulsion significantly.%目的 研究黄连干姜药对的配伍规律.方法 用

  19. 复方阿嗪米特肠溶片治疗胆囊切除术后消化不良的有效性和安全性:随机、双盲、安慰剂对照的多中心临床研究%Efficacy and safety of compound azintamide enteric-coated tablet in the treatment of patients with post-cholecystectomy dyspepsia:a randomized, double-blinded, placebo controlled multicentre clinical trial

    Institute of Scientific and Technical Information of China (English)

    孙菁; 袁耀宗; 房静远; 上海泌特临床协作组

    2014-01-01

    目的 评估复方阿嗪米特肠溶片对胆囊切除术后消化不良的临床疗效和安全性. 方法 采用多中心、随机、双盲、安慰剂平行对照的研究方法,将120例胆囊切除术后消化不良的患者分为阿嗪米特组60例和安慰剂组60例,口服复方阿嗪米特肠溶片或匹配的安慰剂100 mg/次,3次/d,连续服用28 d.治疗前和治疗第7、14、21、28天评估两组患者消化不良症状(腹胀、食欲不振、早饱、暖气、恶心、腹痛或腹部不适)积分和总积分.治疗第28天比较两组消化不良症状改善有效率并进行安全性评估.治疗前和治疗第28天比较两组患者的生活质量评分.应用t检验或卡方检验进行统计学分析.结果 阿嗪米特组在治疗第7天的腹胀、嗳气、恶心和腹痛或腹部不适症状积分和总积分(5.7±3.1、3.5±2.1、0.3±0.1、3.3±1.7、17.9±9.6)较治疗前(8.9±5.3、5.3±2.5、0.9±0.4、4.5±3.7、24.3±14.5)明显降低(t=3.758、3.976、10.494、2.125、2.654,P均<0.05),在治疗第14、21、28天各消化不良症状积分和总积分均较治疗前显著降低;安慰剂组在治疗第7、14、21、28天腹胀较治疗前明显改善,在治疗第28天早饱症状积分和总积分较治疗前显著降低.阿嗪米特组总有效率为66.7%(40/60),高于安慰剂组的38.3%(23/60),差异有统计学意义(x2 =9.653,P<0.01).治疗第28天,阿嗪米特组简明尼平消化不良指数(SF-NDI)量表总评分为4.4±3.4,低于安慰剂组的9.6±6.0,差异有统计学意义(t-5.450,P<0.01).阿嗪米特组1例患者于治疗第7天发生皮疹,安慰剂组1例患者于治疗第14天发生头痛,停药处理7d后症状消失.结论 复方阿嗪米特肠溶片能有效改善胆囊切除术后的消化不良症状,提高患者生活质量,安全性好.%Objective To evaluate the efficacy and safety of compound azintamide enteric-coated tablet in the treatment of patients with post-cholecystectomy dyspepsia

  20. 西沙必利联合双歧三联活菌治疗功能性消化不良的临床观察%Clinical Observation of Cisapride Combined with Bifid Triple Viable in the Treatment of Functional Dyspepsia

    Institute of Scientific and Technical Information of China (English)

    陈达卫

    2011-01-01

    OBJECITVE: To observe the clinical efficacy of cisapride combined with bifid triple viable in the treatment of functional dyspepsia (FD). METHODS: From Jun. 2009 to Jun. 2010, 130 FD patients were randomly classified into 2 groups, which observation group with 65 cases was treated with cisapride combined with bifid triple viable and control group with 65 cases was only treated with cisapride. Clinical efficacy and main symptoms were observed and compared between 2 groups. RESULTS: The total effective rates(90.8% ) in observation group were significantly higher than in control group(67.7% ), there was significant difference (P<0.05). Compared with pre-treatment, the scores of postprandial fullness, epigastric pain, early satiety and nausea were significantly decreased after treatment in both 2 groups, there were significant differences(P<0.05). Moreover, the scores of postprandial fullness, epigastric pain, early satiety and nausea in observation group after treatment were significantly lower than those in control group, there were significant differences (P<0.05). CONCLUSION: Cisapride combined with bifid triple viable in the treatment of FD can improve clinical efficacy and clinical symptoms significantly, compared with cisapride alone.%目的:观察西沙必利联合双歧三联活茵治疗功能性消化不良(FD)的临床疗效.方法:将2009年6月-2010年6月在我院治疗的130例FD患者随机均分为2组,观察组65例采用西沙必利联合双歧三联活茵治疗,对照组65例仅采用西沙必利治疗,观察比较2组的临床疗效和主要症状变化.结果:观察组的总有效率(90.8%)明显高于对照组(67.7%),2组比较差异有统计学意义(P<0.05).2组治疗后餐后饱胀、上腹胀痛、早饱和恶心评分均较治疗前下降,且差异有统计学意义(P<0.05).观察组治疗后餐后饱胀、上腹胀痛、早饱和恶心评分均低于同期对照组,且差异有统计学意义(P<0.05).结论:西沙必利联

  1. A fMRI Study on Brain Perception Response during Water Load Test in Patients with Functional Dyspepsia%功能性消化不良患者水负荷试验时大脑感知作用的fMRI研究

    Institute of Scientific and Technical Information of China (English)

    万坚; 朱莉; 周慧; 毛峻岭; 陆伦根; 张燕华

    2011-01-01

    Visceral sensation transmission and central mechanism of visceral hypersensitivity could be examined by functional magnetic resonance imaging (Fmrt), however, few Fmri studies on central response induced by water load test (WLT) have been reported. Aims: To study the characteristics of cerebral cortex response during WLT in patients with functional dyspepsia (FD), and to investigate the central mechanism of visceral hypersensitivity. Methods: Eleven patients with postprandial distress syndrome (PDS) and 13 patients with epigastric pain syndrome (EPS) diagnosed according to Rome III criteria were enrolled, and 12 healthy volunteers were served as controls. WLT and Fmri were performed. Results: The initial and maximal gastric satiety thresholds of WLT were significantly lower in PDS and EPS groups than in controls (P0.05). Conclusions: The brain perception response of FD patients during WLT may be similar with healthy controls, but the processing, managing or regulating activities in limbic system (mainly insular lobe, anterior cingulate cortex) and temporal lobe, cerebellum, occipital lobe are abnormal, resulting in visceral hypersensitivity. However, no significant difference was found between subtypes of FD.%背景:应用功能性核磁共振成像(fMRI)可提示内脏感觉转导作用和内脏高敏感的中枢机制.目前水负荷试验(WLT)致中枢反应的fMRI研究尚少见.目的:研究功能性消化不良(FD)患者WLT时大脑皮质的信息反应特点,探讨其内脏高敏感的中枢机制.方法:纳入符合罗马Ⅲ标准的11例餐后不适综合征(PDS)、13例上腹痛综合征(EPS)患者以及12名对照者.受试者行WLT时接受fMRI检查.结果:PDS和EPS组胃初次饱足阈值、最大饱足阈值均显著低于对照者(P<0.05).三组激活脑区大部分集中于双侧大脑半球的前扣带回、颞叶、额叶、岛叶(左侧为主)、楔叶(左侧为主)、丘脑、小脑.PDS组胃初次饱足时颞叶、小脑以及最大饱足

  2. 访谈型饮食护理干预糖尿病并发功能性消化不良的临床研究%Clinical Study on the Treatment of Diabetes Mellitus with Functional Dys-pepsia by Interview with the Diet Nursing

    Institute of Scientific and Technical Information of China (English)

    巩雪

    2015-01-01

    目的:探讨访谈型饮食护理在干预糖尿病并发功能性消化不良方面的临床效果。方法选取该院糖尿病并发功能性消化不良的患者100例,随机分为两组,对照组50例,观察组50例。对照组按照一般方法进行干预,观察组采用访谈型饮食护理干预,观察两组患者的临床疗效。结果两组比较后,观察组总有效率为96.00%,对照组总有效率72.00%,观察组痊愈人数与有效人数均多于对照组,差异有统计学意义(χ2=10.714,P0.05);干预1个月后,观察组指标分别为(5.82±0.42) mmol/L、(7.41±0.66) mmol/L、(5.38±0.32)%,对照组分别为(7.85±0.72) mmol/L、(9.63±0.64) mmol/L、(7.21±0.56)%,两组的血糖指标均较干预前明显改善,观察组患者改善程度明显优于对照组,差异有统计学意义(P0.05);1 months after the intervention, the observation group were(5.82±0.42)mmol/L,(7.41±0.66)mmol/L, (5.38±0.32)%, the control group were (7.85±0.72)mmol/L,(9.63±0.64)mmol/L,(7.21±0.56)%, The blood glucose index of the two groups were significantly improved, the improvement of the observation group was significantly better than the control group, the difference was statistically significant (P<0.05);The patients in the two groups were followed up for half a year, the recurrence rate of the observation group was 10%, significantly lower than the control group 32%, there was a significant difference (χ2=7.294, P<0.05). Conclusion The interview based diet nursing intervention has positive clinical significance for the treatment of diabetic patients with functional dyspepsia, and it is worth to be popularized.

  3. Dyspepsia as initial symptom of splanchnic vascular insufficiency

    NARCIS (Netherlands)

    deWidtLevert, LM; Nelis, GF; Jorning, PJG

    1996-01-01

    A patient is reported with an unusual presentation of splanchnic ischaemia, causing gastritis. Although mesenteric ischaemia is well described in the literature, there is little information on gastric ischaemia resulting in gastritis. There was a considerable delay in diagnosis and treatment, adding

  4. Dyspepsia as initial symptom of splanchnic vascular insufficiency

    NARCIS (Netherlands)

    deWidtLevert, LM; Nelis, GF; Jorning, PJG

    A patient is reported with an unusual presentation of splanchnic ischaemia, causing gastritis. Although mesenteric ischaemia is well described in the literature, there is little information on gastric ischaemia resulting in gastritis. There was a considerable delay in diagnosis and treatment, adding

  5. [Dyspepsia, Ulcer Disease – Helicobacter pylori, Gastroesophageal Reflux Disease].

    Science.gov (United States)

    Wirth, Hans-Peter

    2016-06-01

    Prevalence of H. pylori (HP) is declining, whereas reflux disease and the proportion of non-steroidal antiinflammatory drugs (NSAR) to HP-induced ulcers increase. Eradication heals HP-ulcer disease, interrupts cancerous progression and can improve dyspeptic symptoms. NSAR-ulcers heal under proton pump inhibitor (PPI) therapy but tend to recur after reexposition. Anticoagulants and antiplatlet agents increase the risk additionally. PPI reduces NSAR-ulcer recurrence. Reflux patients with severe inflammation and complications often need long-term therapy. Barrett’s esophagus patients are at risk of esophageal adenocarcinoma.

  6. lnfluenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat%舒胃汤对功能性消化不良大鼠P物质与胃窦Cajal间质细胞的影响

    Institute of Scientific and Technical Information of China (English)

    徐寅; 郭璇; 弭艳红; 王小娟; 唐松云; 刘红; 张鑫; 饶文娟; 李永静

    2012-01-01

    Objective: To observe the effects and mechanism of Shuwei decotion on the gastric emptying, substance P ( SP) and gastric antrum of interstitial cells of Cajal ( ICC ) in functional dyspepsia ( FD ) with stagnation of liver-Qi and deficiency of the spleen. Method: The sixty SD rats were randomly divided into 6 groups; Shuwei decoction low dose group, Shuwei decoction high dose group, Muxiang Shunqi pill group, mosapride group, control group and model group, with 10 rats in each group. Shuwei decoction groups were administrated with Shuwei decoction at doses of 7. 67 g · kg-1, 30. 68 g · kg-1, and muxiangshunqi pill group was given Muxiang Shunqi pill of 1. 65 g · kg-1, and mosapride group was given mosapride of 1. 37 mg · kg-1. The rats FD model ws maded by clasping their tails except the control group. After 3 days, the control and model groups were given distilled water ig (10 mL · kg-1 ) ; the normal group and model group were given physiological saline intragastrically; the treated rats were given corresponding drugs for 14 days. To observe gastric emptying, the content of SP were determined by radiommunoassay, structure change of interstitial cells of cajal in gastric ant rum was observed by transmission electron microscope. Result: The gastric emptying was delayed and the content of SP obviously decreased ( P < 0. 05 ) in model group, compared with model group, Muxiang Shunqi pill group (58. 35 ± 8. 71) % , mosapride group (78. 17 ± 10. 74) % , Shuwei decoction low dose group (60. 39 ± 3. 48 ) % and Shuwei decoction high dose group ( 76. 80 ± 6. 96 ) % improved gastric emptying ( P < 0. 05 ) ; compared with SP level (5.32 ±2.12) ng · L-1 of model group, Muxiang Shunqi pill group (12.89 ±2.10) ng · L-1, mosapride group (17.86 ±3.56) ng · L-1, Shuwei decoction low dose group (8.03 ±2.51) ng · L-1 and Shuwei decoction high dose group (13. 79 ±2. 58) ng · L-1 was significantly increased the plasma SP level (P < 0. 05). The structure change of

  7. Effects of anti-somatisation therapy on the quality of life in patients with functional dyspepsia%抗躯体化症状治疗对功能性消化不良患者生活质量的疗效

    Institute of Scientific and Technical Information of China (English)

    明文; 贺国斌; 向军英; 张琴; 李群华

    2014-01-01

    functional dyspepsia (FD) and effects of combined anti somatisation therapy on the quality of life in patients with FD.Methods Two hundred and nineteen patients with FD were enrolled.Patient Health Questionnaire-15 (PHQ-15) and Nepean Dyspepsia Index (NDI) were completed,and the relation between them was analyzed.Lansoprazole,mosapride and flupentixol melitracen (the anti-somatisation medication) were taken for four weeks by 131 FD patients who had poor response to four-week conventional treatment with proton pump inhibitors (PPI) and/or prokinetic medication and who got more than 4 scores in PHQ 15.And then therapeutic effects were observed and the changes of NDI before and after treatment were analyzed.The t test,chi-square test,Spearman's correlation and linear regression were performed for statistical analysis.Results The total PHQ-15 and NDI score of 219 patients with FD were 5.7±3.4 and 42.0± 10.4,and there was positive correlation between them (r=0.493,P<0.05).Stomach pain,headache,chest pain,dizziness,shortness of breath,fatigue,sleeping disorder,thirst and so on were positively correlated with totalNDIscore (r=0.262,0.230,0.241,0.243,0.352,0.385,0.266,0.281,all P<0.05).Chest pain,stomach pain,shortness of breath,dizziness and fatigue were the influence factors of NDI (t=2.340,2.488,5.278,2.167,2.443,all P<0.05).Among 131 patients with FD who received anti somatisation combination therapy,six patients did not complete the therapy because of the side effects,and finally 125 patients were enrolled and analyzed.Before and four weeks after the treatment,the total PHQ-15 scores of 125 patients with FD were 7.3±3.2 and 2.9±2.2,respectively; and the difference was statistically significant (t =12.653,P<0.01).There were significant differences in the influence of stomach pain,headache,chest pain,dizziness,shortness of breath,fatigue,sleeping disorder and thirst before and after the treatment (not bothered at all,bothered a little,bothered a lot) (x2=39.231,6.796

  8. Primary study on the evaluation for the treatment of functional dyspepsia with acupuncture by Dynamic X-ray radiography with gastric barium meal%X 线胃钡餐动态摄影评价针刺治疗功能性消化不良的初步研究

    Institute of Scientific and Technical Information of China (English)

    赵青; 金玉莲; 洪洋; 方继良; 刘志顺; 景向红; 喻晓春; 朱兵

    2014-01-01

    Objective It is to evaluate the changes of gastric motility, serum gastrin and clinical symptom scores after one month's treatment with acupuncture and their relationship in the patients with functional dyspepsia ( FD) by dynamic X-ray radiography with gastric barium meal .Methods Seventeen FD patients were selected according with the Rome III criteria , and their clinical FD scores were evaluated and received examination of dynamic X -ray radiography with barium meal , in which 8 cases were treated with acupuncture for 1 month and were given examination of dynamic X -ray radiography with barium meal , fasting serum gastrin measure and symptom score evaluation before and after treatment .10 normal people were selected as con-trol group and given the same examination .The imaging indexes of X -ray included the height of gastric retention liquid , the width of midgastric transverse band ( MTR) ,the frequency , width and depth of gastric slow waves .Results It showed signifi-cant differences between FD patients and healthy subjects in the imaging indexes of gastric motility including the height of gas -tric retention liquid,MTR,the frequency of stomach wave (P all <0.01).After one weeks'acupuncture in FD patients,single and total symptom scores were significantly decreased (P<0.01), gastric retention liquid and MTR were decreased (P<0.01 or P<0.05), frequency of gastric slow waves was fasted (P<0.01), propagation velocity of gastric slow waves was shortened (P<0.05), the level of serum gastrin was increaed (P<0.01).the outcomes showed these indexes were improved to the normal values closely .In the treatment with acupuncture for FD , gastric motility index was in accordance with the changes of symptom index and serum gastrin .Conclusion The dynamic X-ray radiography with gastric barium meal can be a practical and cheap diagnosis method in evaluating for gastric motility disorder in FD .Acupuncture could treat for FD may through in-creasing the level of serum gastrin

  9. Evaluation of hydrotalcite in treatment of functional dyspepsia epigastric pain syndrome: a multicenter randomized open positive controlled clinical trial%铝碳酸镁咀嚼片治疗功能性消化不良上腹痛综合征的多中心、随机、开放、平行阳性对照临床研究

    Institute of Scientific and Technical Information of China (English)

    孙菁; 房静远; 李兆申; 谢鹏雁; 许乐; 袁耀宗

    2010-01-01

    目的 评价铝碳酸镁咀嚼片治疗功能性消化不良上腹痛综合征的有效性及安全性,并探讨其在首次服药后的起效时间和药物经济学.方法 采用多中心、随机、开放、平行阳性对照设计.将240例功能性消化不良上腹痛综合征患者随机分为铝碳酸镁组和奥美拉唑组,各组连续服药2周.观察治疗后临床症状的改善情况和铝碳酸镁组服药后症状消失时间.同时比较两组药物的成本效应.结果 治疗1周及2周后两组患者的临床症状均得到显著改善.治疗2周后,铝碳酸镁片组总有效率为85.71%;奥美拉唑组总有效率为90.43%.两组间差异无统计学意义(P>0.05).患者在上腹痛发生后,首次服用铝碳酸镁后上腹痛缓解的中位起效时间估计值为0.417 h.铝碳酸镁组平均每治疗1例有效患者的费用为122.29元,奥美拉唑组为242.95元.不良反应主要为腹泻、口干、腹胀、头痛和打嗝等,两组均未发生严重不良事件.结论 铝碳酸镁咀嚼片能通过多种作用途径快速缓解功能性消化不良患者上腹痛综合征的临床症状,且安全有效,其成本效应比显著优于奥美拉唑肠溶胶囊.%Objective To evaluate the clinical efficacy and safety of hydrotalcite chewable tablets in treatment of patients with functional dyspepsia epigastric pain syndrome(EPS), and to investigate the onset time of hydrotalcite after the first dosage and whether use of hydrotalcite in EPS is a costeffective strategy. Methods A multicenter, randomized, open, positive controlled clinical trial was carried out in 240 patients with EPS. The subjects randomly received eigher hydrotalcite or omeprazole for 2 weeks. The improvemcnt and the disappear time of symptoms were evaluated before and after treatment and cost-effective was analyzed between two groups. Results It was demonstrated that both hydrotalcite and omeprazole could relief symptoms after treatment. After treatment for 2 weeks, the

  10. 符合罗马Ⅲ标准FD患者心理测试及自主神经功能观察44例%Psychological states and autonomic nervous system function in 44 patients with functional dyspepsia diagnosed based on the Room III criteria

    Institute of Scientific and Technical Information of China (English)

    吴改玲; 蓝宇

    2012-01-01

    AIM: To investigate the psychological states and autonomic nerve function in patients with functional dyspepsia (FD).METHODS: Forty-four FD patients who were diagnosed according to the Room Ⅲ criteria and 16 healthy volunteers were enrolled in this study. FD patients were divided into postprandial distress syndrome (PDS) group (n = 31) and epigastric pain syndrome (EPS) group (n = 13). Sixteen healthy subjects (HS) were used as controls. Epigastric discomfort and Zung Scale scoring was performed for testing psychological states and autonomic nerve function in all participants.RESULTS: The incidence of depression and/or anxiety was significantly higher in FD patients than in HS (24/44 vs 1/16, P = 0.001). Both the depression score and anxiety score were significantly higher in the FD group than in the HS group (49.36 ± 1.71 vs 34.42 ± 1.98, 39.83 ± 1.57 vs 27.77 ± 0,75, both P = 0.000), in the PDS group(51.40 ± 1.80, 40.39 ± 2.01) than in the HS group (both P = 0.000), and in the EPS group (45.50 ± 3.68,38.52 ± 2.44) than in the HS group (P = 0.026 and 0.001). The heart rate variability (HRV) with deep breathing was significantly lower in FD patients than in HS (17.61 ± 1.18 vs 22.71 ± 2.12, P = 0.031), in EPS patients than in HS (16.17 ± 1.98 vs 22.71 ± 2.12, P = 0.038), and in FD patients with depression and/or anxiety than in HS (17.23 ± 1.49 vs 22.71 ± 2.12, P = 0.036). However, no significant difference was observed between FD patients without depression or anxiety and HS, and between FD patients with and without depression or anxiety.CONCLUSION: Depression and anxiety are notable in FD patients. PDS patients generally suffer more severe depression than EPS patients. Impaired autonomic nerve function is mainly due to the injury of the parasympathetic nerve. Patients with depression and/or anxiety are more likely to have impaired autonomic nerve function.%目的:观察功能性消化不良(functional dyspepsial,FD)及其不同类型患者的心

  11. Gastric motor and sensory function in patients with functional dyspepsia diagnosed based on the Rome Ⅲ Criteria%胃运动和感觉功能在符合罗马Ⅲ标准的功能性消化不良患者中的特点

    Institute of Scientific and Technical Information of China (English)

    吴改玲; 蓝宇; 王玘; 闫冰; 张小晋

    2011-01-01

    AIM: To investigate the changes in gastric motor and sensory function in patients with functional dyspepsia (FD) diagnosed based on the Rome Ⅲ Criteria.METHODS: Forty-four FD patients who were diagnosed according to the Rome Ⅲ Criteria and 10 healthy volunteers were enrolled in this study. FD patients were divided into postprandial distress syndrome (PDS) group (n = 31) and epigastric pain syndrome (EPS) group (n = 13).Ten healthy subjects (HS) were used as controls.Epigastric discomfort scoring, gastric emptying test, and water load test were performed in all participants.RESULTS: The rate of gastric emptying was significantly lower in FD patients and PDS patients than in HS (57.74% ± 5.56%, 56.26% ± 8.12% vs 84.00% ± 5.76%, both P < 0.01). The rate of gastric emptying of the PDS group was significantly lower than that of the EPS group (56.26% ± 8.12%vs 68.08% ± 9.86%, P < 0.05). The threshold volume and satiety volume of drinking water were significantly lower in FD patients than in HS (567.61 mL ± 25.22 mL vs 725.00 mL ± 54.90 mL,917.16 mL ± 39.14 mL vs 1 240.00 mL ± 75.57 mL,P = 0.01, 0.001), and in PDS patients than in H-S (P = 0.006, 0.000) and EPS patients (both P < 0.05.The satiety volume was significantly lower in EPS patients than in HS (P = 0.025).CONCLUSION: Abnormalities of gastric motor and sensory function are common in FD patients. Delayed gastric emptying, and abnormality of proximal gastric relaxation and compliance in PDS patients are more serious than those in EPS patients.%目的:研究符合罗马Ⅲ标准的功能性消化不良(FD)患者的胃运动和感觉功能的特点以及不同类型的FD患者病理生理机制的差异.方法:对符合罗马Ⅲ标准的44例FD患者根据罗马Ⅲ分类标准分为餐后不适综合征(PDS,31例)和上腹痛综合征(EPS,13例)两个类型,10例无症状的健康人作为对照组,对所有受试者均进行上胃肠消化不良症状评分、5 h胃排空检

  12. 功能性消化不良餐后不适综合征患者52例胃中液体食物分布特点%Characteristics of liquid food distribution in the stomach of 52 patients with postprandial distress syndrome-predominated functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    吕林; 王静; 唐旭东; 黄穗平; 王凤云; 康楠; 陈婷; 朱恩林; 王晓鸽

    2015-01-01

    Objective To explore the distribution of the liquid food in the stomach of patients with postprandial distress syndrome (PDS)-predominated functional dyspepsia (FD)and the mechanism of its gastric dynamic dysfunction.Methods Fifty-two patients with PDS and 18 healthy volunteers underwent gastric emptying examination with ultrasound scanner provided.The proximal and distal gastric area and volume,area and volume ratio of proximal and distal gastric as well as emptying rate of proximal and distal gastric were calculated at fasting,maximum satiety,30 min,60 min,90 min and 120 min after meal. Student′s t test andχ2 test were performed for statistical analysis.Results Proximal gastric volume of PDS group at the time of fasting and 120 min after meal were (9.06±7.88)and (24.72±24.02)cm3 ,which were larger than those of healthy control group ((5 .96 ± 2.13 )cm3 ,(19.48 ± 12.32 )cm3 ),and the differences were statistically significant (t=-1 .637 and -0.875 ,both P distal gastric volume in PDS group and healthy group at fasting was 0.60 ± 0.38 and 0.46 ± 0.19, respectively,that at maximum satiety was in PDS group and healthy group 0.91 ±0.27,1 .30 ±0.48, respectively,and the differences were statistically significant (t = - 1 .505 and 3.970,both P 0.05 ).Conclusions The volume of distal stomach was larger than that of proximal stomach in PDS patients at maximum satiety in liquid food distribution,which may be the cause of decreasing emptying rate of proximal stomach.And proximal stomach dominated gastric motility in PDS patients.%目的探讨功能性消化不良(FD)餐后不适综合征(PDS)患者液体食物胃中分布情况,了解其胃动力障碍发病机制。方法应用超声诊断仪对52例 PDS 患者和18名健康志愿者进行胃排空检查,在空腹,最大饱腹感,餐后30、60、90和120 min 分别计算近端胃与远端胃面积和容积,近端胃与远端胃面积比率和容积比率,近端胃和远端胃排

  13. 厚朴排气合剂治疗功能性消化不良的多中心随机对照临床研究%Houpu Paiqi mixture in treatment of functional dyspepsia:a multicenter randomized controlled study

    Institute of Scientific and Technical Information of China (English)

    杜奕奇; 蔡建庭; 黄智铭; 于晓峰; 李兆申; 王晓素; 苏暾; 方军; 许洪伟; 李延青; 许建明; 胡乃中; 任建林

    2016-01-01

    Objective To evaluate the efficacy and safety of Houpu Paiqi mixture in treatment of functional dyspepsia (FD)with abdominal distension symptom.Methods From July 2014 to June 2015 , in nine centers,a total of 162 FD patients with abdominal distension symptom and met Rome Ⅲpostprandial distress syndrome (PDS)diagnostic criteria were enrolled.All patients were randomly divided into trial group and control group,81 patients in either group.The patients of trial group and control group took Houpu Paiqi mixture or placebo,respectively,25 mL per time,twice daily,and both the courses of treatment were two weeks.Before and after the treatment,the improvement of main symptoms,total clinical efficacy rate and efficacy of traditional medicine between two groups were compared.Chi square test,Fisher exact probability method and Wilcoxon test were performed for statistical analysis.Results According to the results of per-protocol (PP)analysis,the total efficacy rate of trial group and control group was 69.4% (50/72)and 59.2% (42/71),respectively,and there was no statistically significant difference in total efficacy rate between the two groups (χ2 =1 .650,P =0.199 ). And there was no statistically significant difference in the improvement of PDS main symptoms(postprandial fullnessand early satiety)between the two groups (56.3% ±27.9% vs 54.4% ±32.1%,t =0.606,P =0.727 ).For those with baseline symptom score over 14,median early satiety score of trial group after the treatment was 0,which was lower than that of control group,and the difference was statistically significant (Z =-2.370,P =0.018).The total efficacy rate of traditional medicine of trial group was 80.8% (59/73 )and that of control group was 72.0% (54/75 ),and the difference was not statistically significant (χ2 = 0.676,P =0.411 ).Conclusion Houpu Paiqi mixture has certain efficacy in FD with abdominal distension,and could be used for the treatment of PDS-predominant FD.%目的:评价厚朴排气合剂治疗有

  14. 影响陕南山区消防官兵功能性消化不良发生率及相关因素分析%Analysis of the incidence and related factors for affecting the functional dyspepsia of fire officers and soldiers in a certain mountain

    Institute of Scientific and Technical Information of China (English)

    张阿妮

    2012-01-01

    OBJECTIVE To investigate the incidence of functional dyspepsia (FD) of fire officers and soldiers in a certain mountain and analyze the relevant factors. METHODS Took the international functional gastrointestinal disorders Roman diagnostic criteria FD symptom scale to investigate the 200 fire officers and soldiers 1 000-2 200 m height above sea level. The possible related risk factors were taken for univariate and multivariate Logistic regression analysis. RESULTS In all fire officers and soldiers, 61 cases were diagnosed with FD, the prevalence was 30.5%. The clinical signs of upper abdominal pain were in 13 cases in the 61 cases of FD patients (21.3%). The sense of fullness was in 15 cases (24.6%) , burning sensation was in 11 cases (18.0%) , early satiety was in 9 cases (14.8%), acid reflux was in 5 cases (8.2%), nausea was in 3 cases (4.9%) and belching was in five cases (8.2%). Compared in the four items of the somatization, depression, anxiety and psychotic for FD group and health group (P< 0.05), the difference was statistically significant. The result of univariate analysis showed that fire officers and soldiers smoking (x2 = 4.236) , drinking (x2 = 3.983) , liking the cold food (x2 = 3.319) , anxiety (x2 = 3.271), participating in firefighting and rescue (x2 = 3.493) five factors were the risk factors of FD that affected the fire officers and soldiers, P< 0.05. The multi-variable Logistic regression analysis showed that smoking (OR = 6.358), liking the cold food (OR = 5.472), anxiety (OR = 5.253) were the risk factors that affected FD (P< 0.05), the difference was statistically significant. CONCULSION The incidence of FD for mountain fire officers and soldiers is higher, smoking, like eating the cold food, drinking, anxiety and often participating in firefighting and rescue are the risk factors of FD.%目的 调查陕南山区消防官兵功能性消化不良(FD)的患病的发生率及分析其相关因素.方法 采用国际功能性胃肠病罗马诊

  15. 2型糖尿病、糖尿病肾病患者幽门螺杆菌感染及胃黏膜病变发病率临床研究%Investigation on the prevalence of Helicobacter pylori infection and the incidence of gastric mucosal lesions in type 2 diabetes mellitus and diabetic kidney disease patients with dyspepsia symptoms

    Institute of Scientific and Technical Information of China (English)

    钟晓琴; 周飞; 刘丽秋

    2016-01-01

    DM和 DKD 患者胃黏膜病变类型与非糖尿病患者无差异。%Objective To investigate the prevalence of Helicobacter pylori infection and the incidence of gastric mucosal lesions in type 2 diabetes mellitus(DM)and diabetic kidney disease(DKD)patients with dyspepsia symptoms.Methods A total of 241 type 2 diabetic patients and 69 non -diabetic subjects with dyspeptic symptoms were enrolled in the study.Gastroduodenal lesions were observed by gastrointestinal endoscopy and the presence of Helicobacter pylori infection was identified by rapid urease test and serum IgG antibodies to Helicobacter pylori.Urine albumin excretion rate(UAE)at 24 hours was measured in all subjects.According to the urinary albumin excretion rate,patients were classified into diabetes mellitus group(DMgroup,with UAE 300mg/24h).Estimated glomerular filtration rate were above 60mL·min -1 ·(1.73m2 )-1 in the three groups of patients.The 69 cases of non -diabetic subjects were used as the control group.Results The prevalence of H pylori infection in the DKD group[145 /72(62.5%)]and the DKD group 2[34 /53(64.15%)]were significantly higher than those in the control group[28 /65(43.1%)](χ2 =3.901,P =0.04;χ2 =4.223,P =0.03)and the DM group [27 /63 (42.9%)](χ2 =4.104,P =0.04;χ2 =5.116,P =0.03).No significant differences of H.pylori prevalence were detected between the DKD groups(χ2 =1.304,P =0.29)as well as the DMgroup and the control group (χ2 =0.723,P =0.40).Gastroscopy results showed that the incidence of normal endoscopic performance in the DMgroup was higher than that of the control group(57.1% vs.38.5%,χ2 =4.612,P =0.03).There were no significant differences between the control group and DM group,DKD1 group and DKD2 group in the incidence of gastric mucosal lesions (Superficial gastritis:χ2 =1.206,0.912,0.707;erosive gastritis:χ2 =1.422,1.836 0.870;duodenal ulcer:χ2 =243.1, 1.716,2.233;gastric ulcer:χ2 =1.440,0.971,1.322 and esophagitis:χ2 =2.116,2.318,2.488,all P >0

  16. Correlation between diarrhea type irritable bowel syndrome overlapped with functional dyspepsia and psychology and gastrointestinal hormones%腹泻型肠易激综合征重叠功能性消化不良与精神心理、胃肠激素的相关性

    Institute of Scientific and Technical Information of China (English)

    赵梁; 宋雯; 朱萍; 陈齐鸣; 朱海杭; 张旭东; 张瑜; 张妮娜; 卜平

    2013-01-01

    目的 探讨腹泻型肠易激综合征(IBS)重叠功能性消化不良(FD)患者精神心理状况及其与脑肠肽、细胞因子水平差异的相关性.方法 选取190例腹泻型IBS重叠FD患者及30名健康对照者完成临床问卷,并应用成人心理测验系统进行SCL-90心理测评,随机抽取其中59例患者检测血浆5-羟色胺、生长抑素(SS)、血管活性肠肽(VIP)、内皮素及IL-10等水平.统计学处理采用单因素方差分析和LSD检验.结果 腹泻型IBS重叠FD患者中,腹泻型IBS为主和FD为主患者血浆5-羟色胺水平分别为(1906.83±676.88) μg/L和(1745.53±653.23) μg/L,均高于对照组的(1289.44±918.45) μg/L(LSD检验,P均<0.05),VIP、IL-10水平均低于对照组(LSD检验,P均<0.01).腹泻型IBS为主患者血浆SS水平低于对照组(LSD检验,P=0.025),内皮素水平高于对照组及FD为主患者(LSD检验,P均<0.05).腹泻型IBS重叠FD患者焦虑、抑郁、敌对量表评分均高于对照组(F=5.114、4.555、10.285,P均<0.05).合并抑郁和(或)焦虑状态患者血浆VIP、SS水平低于对照组(LSD检验,P均<0.05),VIP水平亦低于无相应心理异常患者(LSD检验,P=0.005).病程>5年患者血浆内皮素水平高于病程<1年及1~5年患者(LSD检验,P均<0.05),IL-10水平低于病程<1年患者(LSD检验,P=0.004).结论 腹泻型IBS重叠FD患者存在心理亚健康状态,其症状重叠可能与病程、精神心理异常和血浆5-羟色胺水平升高、IL-10水平降低有关;血浆VIP、SS水平降低及内皮素水平升高可能与本病的下消化道症状密切相关.%Objective To investigate the psychological status of diarrhea type irritable bowel syndrome (D-IBS) patients overlapped with functional dyspepsia (FD) and its relationship with the changes of brain-gut peptides and cytokines levels.Methods A total of 190 D-IBS FD overlapped patients and 30 healthy controls were selected and all of them completed the questionnaire.The adult

  17. Prospective randomized study of viscous lidocaine versus benzocaine in a GI cocktail for dyspepsia.

    Science.gov (United States)

    Vilke, Gary M; Jin, Albert; Davis, Daniel P; Chan, Theodore C

    2004-07-01

    We hypothesized that Benzocaine (Hurricaine) would work as quickly and effectively as viscous Lidocaine in this preparation. This was a prospective randomized, single-blinded comparison between Benzocaine and Lidocaine as the topical anesthetic in a gastrointestinal (GI) cocktail. Patients 18 years or older were approached for participation when a GI cocktail was ordered by the Emergency Physician. Patients were randomized to equivalent doses of either Benzocaine or viscous Lidocaine in addition to 30 cc of Maalox and 10 cc of Donnatal. Assessment using a visual analog pain scale occurred at time intervals of 0, 5, 15, and 30 min. Eighty-two patients were enrolled (44 to Benzocaine, 38 to viscous Lidocaine), with each group having a statistically significant improvement in pain (p Benzocaine and viscous Lidocaine groups in terms of the relief of symptoms at each of the assessment times. There were no adverse outcomes in either group.

  18. [Helicobacter pylori infection in children without dyspepsia in Curundu and Parque Lefevre].

    Science.gov (United States)

    Halphen, G M; Lindsay Estupiñán, J; Márquez, L E; Pon Chow, R L; Méndez, J R; Brandáriz, C; Oduber, L; Chanis, R

    1998-01-01

    A study of seroprevalence of Helicobacter pylori determined by ELISA IgG, was conducted in 83 consecutive healthy children. The majority of the children (55%) had the bacterium. Seropositivity was demonstrated in 55% of the age group 0-5 years old, in 47% of 6-10, and in 67%, of the group 11 to 15. Of the children without sanitary inside their homes 86% were seropositive, versus 47% of the children with sanitary in their homes.

  19. Association of anxiety, depression, and psychological distress in people with and without functional dyspepsia

    Directory of Open Access Journals (Sweden)

    Peyman Adibi

    2016-01-01

    Conclusions: The prevalence of FD is less in males than females, but psychological links were stronger in males. Thus, it is essential to consider and detect the psychological distress in these patients.

  20. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin

    DEFF Research Database (Denmark)

    Andersen, L.P.; Holck, Susanne; Kupcinskas, L.;

    2007-01-01

    . There was a significant decrease in gastric inflammation in H. pylori-positive patients from both groups. There were no significant changes in the density of H. pylori or in any of the interleukins during or after treatment. There was a significant up-regulation of CD4 and down-regulation of CD8 in patients with H....... pylori treated with astaxanthin. Astaxanthin had an effect on the inflammation and on the density of H. pylori in mice in a study where the diet could be standardized without antioxidants (Bennedsen et al., 1999). These dietary conditions are impossible in studies involving humans, and may be due...

  1. Burden of comorbidities among Japanese patients with atrial fibrillation: a case study of dyspepsia [Corrigendum

    Directory of Open Access Journals (Sweden)

    Kinoshita Y

    2013-09-01

    Full Text Available Kinoshita Y, DiBonaventura M, Rossi B, Iwamoto K, Wang ECY, Briere JB. Clin Exp Gastroenterol. 2013;6:51–59.On page 54, in the second paragraph, line 6, note that "26.65% versus 17.02%" should be "29.65% versus 17.02%".View original paper by Kinoshita Y, DiBonaventura M, Rossi B et al. 

  2. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin

    DEFF Research Database (Denmark)

    Andersen, L.P.; Holck, Susanne; Kupcinskas, L.

    2007-01-01

    The chronic active inflammation caused by Helicobacter pylori is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins are involved in the inflammatory process. The aim of this study was to investigate the effect of astaxanthin on gastric inflammation in patien...

  3. Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population

    DEFF Research Database (Denmark)

    Rasmussen, Sanne; Jensen, Trine Holm; Henriksen, Susanne Lund

    2014-01-01

    of the three conditions in a Western general population. Material and methods. A nationwide study of 100,000 individuals 20 years and above, randomly selected in the general population. A web-based questionnaire survey formed the basis of this study. Questions regarding FD and IBS were extracted from the ROME...... III adult questionnaire. Questions regarding GERD were developed based on the Montreal definition. Prevalence estimates for GERD, FD IBS were calculated in total and for each sex separately and for four age groups. A Venn diagram was constructed, illustrating the overlap between the three conditions....... Results. The overall response rate was 52.2%. The prevalence of GERD, FD and IBS was 11.2%, 7.7% and 10.5%, respectively, and overlap between two or three of these conditions was seen among 6.5% of the respondents. Among individuals meeting the criteria of one or more of the conditions GERD, FD and IBS...

  4. Itopride for gastric volume,gastric emptying and drinking capacity in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Shahab; Abid; Wasim; Jafri; Maseeh; Uz; Zaman; Rakhshanda; Bilal; Safia; Awan; Aamir; Abbas

    2017-01-01

    AIM To study the effect of itopride on gastric accommodation, gastric emptying and drinking capacity in functional dyspepsia(FD). METHODS Randomized controlled trial was conducted to check the effect of itopride on gastric accommodation, gastric emptying, capacity of tolerating nutrient liquid and symptoms of FD. We recruited a total of 31 patients having FD on the basis of ROME III criteria. After randomization, itopride was received by 15 patients while 16 patients received placebo. Gastric accommodation was determined using Gastric Scintigraphy. 13 C labeled octanoic breadth test was performed to assess gastric emptying. Capacity of tolerating nutrient liquid drink was checked using satiety drinking capacity test. Theintervention group comprised of 150 mg itopride. Patients in both arms were followed for 4 wk. RESULTS Mean age of the recruited participant 33 years(SD = 7.6) and most of the recruited individuals, i.e., 21(67.7%) were males. We found that there was no effect of itopride on gastric accommodation as measured at different in volumes in the itopride and control group with the empty stomach(P = 0.14), at 20 min(P = 0.38), 30 min(P = 0.30), 40 min(P = 0.43), 50 min(P = 0.50), 60 min(P = 0.81), 90 min(P = 0.25) and 120 min(P = 0.67). Gastric emptying done on a sub sample(n = 11) showed no significant difference(P = 0.58) between itopride and placebo group. There was no significant improvement in the capacity to tolerate liquid in the itopride group as compared to placebo(P = 0.51). Similarly there was no significant improvement of symptoms as assessed through a composite symptom score(P = 0.74). The change in QT interval in itopride group was not significantly different from placebo(0.10). CONCLUSION Our study found no effect of itopride on gastric accommodation, gastric emptying and maximum tolerated volume in patients with FD.

  5.   A Cost-Effectiveness Analysis of Two Management Strategies for Dyspepsia

    DEFF Research Database (Denmark)

    Kjeldsen, Hans Chr; Bech, Mickael; Christensen, Bo

    2007-01-01

    June 2000 to August 2002, Aarhus County, Denmark. We randomly assigned 368 dyspeptic patients from 32 general practices to treatment with omeprazol 40 mg for two weeks (n: 184) or endoscopy (n: 184). The study adopted a societal perspective, and the year of costing was 2006. Outcome measures: days free...

  6. Helicobacter pylori and Its Virulence Factors' Effect on Serum Oxidative DNA Damages in Adults With Dyspepsia

    Directory of Open Access Journals (Sweden)

    Heshmat Shahi

    2016-12-01

    Full Text Available Helicobacter Pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. Inflammatory aspects may prompt the production of radical oxygen substance (ROS which may damage cells and release 8-hydroxydyoxyguanosine (8-OHdG to serum. In this study, we evaluate the prevalence of H. pylori virulence factors and the association between serum level of 8-OHdG, H. pylori infection, and its various virulence factors. The presence of H. pylori and prevalence of cagA, babA and oipA genes in samples were determined by rapid urease test (RUT, histopathological exam (HE and polymerase chain reaction (PCR and oxidative DNA damage situation were assessed by using serum level of 8-OHdG. There was not any direct relation between H. pylori negative and H. pylori oipA+specimens by 8-OHdG serum level (P>0.05. In all clinical observations, the presence of cagA and oipA genes was common. There was a statistical relationship between the presence of cagA, babA factors, and high serum level of 8-OHdG (P<0.05. The presence of cagA and babA virulence factors may be associated with increased serum 8-OHdG in dyspeptic patients and may induce the damage to gastric cells.

  7. Helicobacter pylori and Its Virulence Factors' Effect on Serum Oxidative DNA Damages in Adults With Dyspepsia.

    Science.gov (United States)

    Shahi, Heshmat; Bahreiny, Rasoul; Reiisi, Somayeh

    2016-11-01

    Helicobacter Pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. Inflammatory aspects may prompt the production of radical oxygen substance (ROS) which may damage cells and release 8-hydroxydyoxyguanosine (8-OHdG) to serum. In this study, we evaluate the prevalence of H. pylori virulence factors and the association between serum level of 8-OHdG, H. pylori infection, and its various virulence factors. The presence of H. pylori and prevalence of cagA, babA and oipA genes in samples were determined by rapid urease test (RUT), histopathological exam (HE) and polymerase chain reaction (PCR) and oxidative DNA damage situation were assessed by using serum level of 8-OHdG. There was not any direct relation between H. pylori negative and H. pylori oipA+specimens by 8-OHdG serum level (P>0.05). In all clinical observations, the presence of cagA and oipA genes was common. There was a statistical relationship between the presence of cagA, babA factors, and high serum level of 8-OHdG (P<0.05). The presence of cagA and babA virulence factors may be associated with increased serum 8-OHdG in dyspeptic patients and may induce the damage to gastric cells.

  8. Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease.

    Science.gov (United States)

    Nunes, Alexandra; Rocha, Raquel; Vale, Filipa F; Vieira, Luís; Sampaio, Daniel A; Dias, Ricardo; Gomes, João P; Oleastro, Mónica

    2015-02-05

    We present draft genome sequences of 10 Helicobacter pylori clinical strains isolated from children. This will be important for future studies of comparative genomics in order to better understand the virulence determinants underlying peptic ulcer disease.

  9. Patient-directed strategy to reduce prescribing for patients with dyspepsia in general practice : a randomized trial

    NARCIS (Netherlands)

    Krol, N.; Wensing, M.; Haaijer-Ruskamp, F.; Muris, J.W.M.; Numans, M.E.; Schattenberg, G.; van Balen, J.; Grol, R.

    2004-01-01

    Background: The percentage of patients receiving long-term treatment with acid suppressive drugs, mainly proton pump inhibitors, is higher than the prevalence of diseases that are commonly accepted as the proper indication for long-term proton pump inhibitor use. Aim: To evaluate whether a patient-d

  10. Patient-directed strategy to reduce prescribing for patients with dyspepsia in general practice: a randomized trial.

    NARCIS (Netherlands)

    Krol, N.P.; Wensing, M.J.P.; Haaijer-Ruskamp, F.; Muris, J.W.M.; Numans, M.E.; Schattenberg, G.T.B.M.R.; Balen, J.A. van; Grol, R.P.T.M.

    2004-01-01

    BACKGROUND: The percentage of patients receiving long-term treatment with acid suppressive drugs, mainly proton pump inhibitors, is higher than the prevalence of diseases that are commonly accepted as the proper indication for long-term proton pump inhibitor use. AIM: To evaluate whether a patient-d

  11. Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial.

    NARCIS (Netherlands)

    Kerkhoven, L.A.S. van; Laheij, R.J.F.; Aparicio, N.; Boer, W.A. de; Hazel, S Van den; Tan, A.C.; Witteman, B.J.M.; Jansen, J.B.M.J.

    2008-01-01

    BACKGROUND & AIMS: Antidepressants could be effective in the treatment of functional gastrointestinal disorders through their anticholinergic and pain-modulating effects. Previous studies with these drugs lacked sufficient power and were predominantly conducted in patients with irritable bowel syndr

  12. Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia : An individual patient data meta-analysis

    NARCIS (Netherlands)

    Ford, AC; Qume, M; Moayyedi, P; Arents, NLA; Lassen, AT; Logan, RFA; McColl, KEL; Myres, P; Delaney, BC

    2005-01-01

    Background & Aims: Helicobacter pylori "test and treat" has been recommended for the management of young dyspeptic patients without alarm symptoms, and trials have suggested that it is as effective as endoscopy. However, none of these trials have had sufficient sample size to confirm that "test and

  13. Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials

    Directory of Open Access Journals (Sweden)

    Yu Guo

    2016-07-01

    Conclusion: This meta-analysis demonstrates that CHM has a therapeutic potential in treating FD with a certain safety. However, due to the restricted number of trials included, well-planned, long-term studies are necessary to provide credible evidence.

  14. Equally high prevalences of infection with cagA-positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis-associated dyspepsia.

    OpenAIRE

    Pan, Z J; Hulst, R.W. van der; Feller, M.; Xiao, S D; Tytgat, G N; Dankert, J.; Ende, A. van der

    1997-01-01

    Approximately 60% of Helicobacter pylori isolates in the Western world possess the cytotoxin-associated gene A (cagA). cagA-positive H. pylori is found to be associated with peptic ulcer disease (PUD) and gastric adenocarcinoma. To investigate the cagA status of H. pylori isolates from Chinese patients with PUD and chronic gastritis (CG), H. pylori populations from 83 patients, 48 with PUD and 35 with CG, were assessed by two different cagA-specific PCRs, Southern blotting, and colony hybridi...

  15. Progress of the menopausal patients with functional dyspepsia%围绝经期功能性消化不良的研究进展

    Institute of Scientific and Technical Information of China (English)

    李翠红; 童昌珍; 游小伟; 桑红灵

    2005-01-01

    人类由中年进入老年的过度阶段称为围绝经期(peri-menopausal),此时可出现一系列症状叫围绝经期综合征(peri—menopausal syndrome)。围绝经期是世界卫生组织1994年通过讨论而用以代替妇女更年期名称的建议。女性40岁以后任何时期开始,当出现卵巢功能衰退的临床表现时,即可认为进入了围绝经期,围绝经期临床表现复杂,症状多变,

  16. Comparison between empirical prokinetics, Helicobacter testand-treat and empirical endoscopy in primary-care patients presenting with dyspepsia: A one-year study

    Institute of Scientific and Technical Information of China (English)

    Wayne HC Hu; CK Chan; Gabriel M Leung; WM Hui; SK Lam; Cindy LK Lam; WM Wong; KF Lam; KC Lai; YH Wong; Benjamin CY Wong; Annie OO Chan

    2006-01-01

    AIM: To investigate the optimal strategy to treat dyspeptic patients in primary care.METHODS: Dyspeptic patients presenting to primary care outpatient clinics were randomly assigned to:(1) empirical endoscopy, (2)Hpylori test-and-treat,and (3) empirical prokinetic treatment with cisapride.Early endoscopy was arranged if patients remained symptomatic after 2 wk. Symptom severity, quality-oflife (SF-36) as well as patient preference and satisfaction were assessed. All patients underwent endoscopy by wk 6. Patients were followed up for one year.RESULTS: Two hundred and thirty four patients were recruited (163 female, mean age 49). 46% were H pylori positive. 26% of H pylori tested and 25% of empirical prokinetic patients showed no improvement at wk 2follow-up and needed early endoscopy. 15% of patients receiving empirical cisapride responded well to treatment but peptic ulcer was the final diagnosis. Symptom resolution and quality-of-life were similar among the groups. Costs for the three strategies were HK$4343,$1771 and $1750 per patient. 66% of the patients preferred to have early endoscopy.CONCLUSION: The three strategies are equally effective. Empirical prokinetic treatment was the least expensive but peptic ulcers may be missed with this treatment. The H pylori test-and-treat was the most cost-effective option.

  17. Symptomatic response to blocked and unblocked pentagastrin stimulation in functional dyspepsia - Comparison of responders and non-responders to omeprazole identified in a single-subject trial model

    DEFF Research Database (Denmark)

    Madsen, L.G.; Bytzer, P.

    2008-01-01

    -over design. Epigastric pain was assessed every 15 for 90 min after stimulation using a 5-graded Likert scale and a VAS scale. A positive acid provocation test was defined as an increase of the Likert score of epigastric pain by at least one grade after pentagastrin stimulation during placebo treatment...

  18. Comparison of enzyme immunoassays detecting Helicobacter pylori specific IgG in serum and saliva with endoscopic and biopsy findings in patients with dyspepsia

    Directory of Open Access Journals (Sweden)

    A El-Mekki

    2011-01-01

    Full Text Available Purpose: To compare the performance of two indirect enzyme-linked immunosorbent assays (ELISA detecting Helicobacter pylori (HP-specific IgG antibodies in serum and saliva with endoscopic observations and histologic findings of biopsies from dyspeptic patients, in an area of high HP prevalence. Materials and Methods : Sera, saliva and antral biopsies were obtained from 55 dyspeptic patients. IgG antibodies against HP were assayed in sera and saliva utilizing two indirect ELISAs. Biopsies were processed according to standard procedures in order to detect histological changes and the presence or absence of Helicobacter pylori. Laboratory data thus obtained were compared and statistically analyzed. Results: Forty-two (76.36% biopsies were positive for HP. The organisms were detected in 4 of 16 (25% cases with normal endoscopic findings, in all 16 cases of gastritis and in 22 of the 23 (95.6% cases of duodenal ulcers (DU. Serum and saliva HP-specific IgG antibodies were detected in 4 normal cases with positive biopsies, in 12 and 14 cases of gastritis, respectively, and in all 22 (100% biopsy positive cases of DU. The sensitivities of the serum and saliva tests were 90.5% and 95%, respectively, while the specificities were 84.5% and 70%, respectively. Conclusion: Due to their high sensitivity and specificity in diagnosing HP-associated DU and gastritis, serum and saliva antibody testing seems to offer a valuable alternative to invasive procedures especially in areas of high HP prevalence such as ours; saliva antibody testing is simple and practical especially in children and in difficult patients who resent venipuncture.

  19. Nonulcer Stomach Pain

    Science.gov (United States)

    ... stomach pain is also called functional dyspepsia (dis-PEP-see-uh) or nonulcer dyspepsia. Nonulcer stomach pain ... may help inhibit the activity of neurons that control intestinal pain. Antibiotics. If tests indicate that a ...

  20. Understnaging on the Relation between Functional Dyspepsia and Psycology Based on the Traditional Chinese Medicine%功能性消化不良与心理因素相关的中医学认识

    Institute of Scientific and Technical Information of China (English)

    林轩汉; 沈洪

    2008-01-01

    功能性消化不良(functional dyspepsia,FD)是临床上常见的上消化道症候群,也是FGID(功能性胃肠病)中最常见的一类疾病,据最新罗马Ⅲ标准本病可分为餐后不适综合征、上腹疼痛综合征,据其临床症状多归属于中医学“胃脘痛”、“痞满”等范畴。过去单一的生物学病因疾病模型,忽略了中枢神经系统及心理因素在疾病中发挥的作用。现代生物医学社会模式认为症状既可以是病理原因引起的,也可受社会文化和心理因素影响。

  1. 幽门螺杆菌感染与儿童功能性消化不良的关系%Correlation between Helicobacterpylori infection and functional dyspepsia in children

    Institute of Scientific and Technical Information of China (English)

    黄开宇; 卢华君; 胡伟国; 朱欢; 朱世钗

    2006-01-01

    目的 探讨幽门螺杆菌(H.pylori)感染对功能性消化不良(FD)儿童症状、病理及胃排空的影响.方法 FD儿童110例,H.pylori阴性组30例,H.pylori阳性组80例,H.pylori阳性组按不同的治疗方案分A组(吗丁啉组)30例,B组(H.pylori根除+吗丁啉治疗后复查H.pylori转阴者)42例.比较各组症状积分、胃窦粘膜病理积分和胃液体排空情况.结果 H.pylori阳性组饱胀和食欲下降症状重于阴性组(P<0.05),根除H.pylori后上述症状明显改善.H.pylori阳性组胃窦液体排空慢于阴性组,根除H.pylori后排空加快(P<0.05).结论 H.pylori感染是FD患儿的致病因素之一,H.pylori感染可能影响FD儿童的胃排空,根除H.pylori可改善胃排空从而减轻临床症状.

  2. Effect of Helicobacter pylori Eradication on Functional Dyspepsia%根除幽门螺杆菌对功能性消化不良疗效的研究

    Institute of Scientific and Technical Information of China (English)

    吴勇刚; 宋芹书; 李晓波

    2010-01-01

    功能性消化不良(FD)的患病率始终居高不下,目前就幽门螺杆菌(H.pylori)阳性的FD患者是否需根除H.pylori尚存在争议.目的:探讨根除H.pylori对H.pytori阳性FD患者的疗效.方法:200例H.pylori阳性FD患者随机分为治疗组(100例,予以枸橼酸铋雷尼替丁400 mg+阿莫西林1000 mg+克拉霉素250 mg,2次/d,疗程1周)和对照组(100例,予以铝碳酸镁1000 mg,3次/d,疗程1周).随访结束后评估H.pylori根除率和FD症状改善情况.结果:治疗组的H.pylori根除率分别为87.5%(PP分析)和84.0%(ITT分析),对照组H.pylori根除率为0%.H.pylori根除亚组FD症状改善的总有效率显著高于H.pylori未根除亚组和对照组(90.5%对41.7%和45.9%,P<0.01).结论:部分H.pylori阳性FD患者根除H.pylori后,其症状可长期缓解,因此对部分H.pylori阳性FD患者根除H.pylori是一种值得推广的有效治疗手段.

  3. Comparison of Rome III Criteria and Rome II Criteria in the Diagnosis of Functional Dyspepsia%功能性消化不良罗马Ⅲ与罗马Ⅱ诊断标准比较

    Institute of Scientific and Technical Information of China (English)

    穆红

    2011-01-01

    目的 通过比较功能性消化不良罗马III与罗马II标准的诊断差异,评价罗马III诊断标准在功能性消化不良诊断中的价值.方法 对1840例功能性消化不良的患者按照不同的诊断标准分成2组:罗马III标准组和罗马II标准组.比较两组的发现率、亚型所占比例、一般情况、发病相关因素等.结果 ①1840例FD患者中符合罗马Ⅲ标准的有1454例(79.0%),符合罗马Ⅱ标准的有995例(54.1%),差异有统计学意义(P=0.001).同时符合罗马Ⅱ和罗马Ⅲ标准的有803例.②按罗马Ⅲ标准各亚型构成比为:仅符合EPS者占73.25%,仅符合PDS者占18.29%,同时符合PDS和EPS标准者占8.46%.按罗马Ⅱ标准各亚型构成比为:溃疡样型占63.42%,运动障碍型占27.54%,非特异性型占9.04%.③按罗马Ⅱ和罗马Ⅲ标准诊断为FD的两组患者均以女性为主,但性别、年龄、HP感染、心理状态比较差异均无统计学意义.结论 罗马III诊断标准更利于临床实践、应用.

  4. Assessment of psychological state and quality of life in patients with functional dyspepsia%三种量表对FD患者心理状态与生活质量的评价

    Institute of Scientific and Technical Information of China (English)

    安雅萍; 安惠霞; 李书平; 赵进

    2009-01-01

    目的 调查功能性消化不良(functional dispepsia, FD)患者与健康人在焦虑、抑郁状态方面的差异,并对FD患者的生活质量进行分析.方法 采用Zung焦虑自评量表(SAS)、抑郁自评量表(SDS)及汉化版SF-36量表对69例FD患者和69名健康对照者进行评分,比较两组受试者在焦虑、抑郁情绪方面及生活质量的的差异.结果 FD患者的SAS、SDS分值及SAS合并SDS的发生率均明显高于健康对照组( P <0.05),同时FD患者的生活质量评分较对照组明显下降( P <0.05).结论 功能性消化不良患者有明显的焦虑和抑郁倾向,躯体生理健康和精神心理健康均明显受损,生活质量较健康人低,尤其是在精神心理健康方面.

  5. Study on the Pharmacokinetics of Combined Medication in Treatment of Rats with Functional Dyspepsia%联合用药治疗大鼠功能性消化不良的药动学研究

    Institute of Scientific and Technical Information of China (English)

    单国冰; 田媛; 黄俊; 黄寅; 张尊建

    2012-01-01

    Objective To investigate the pharmacokinetic interactions after oral administration of mosapride citrate,omeprazole and hydrochloride fluoxetine in treatment of rats with functional dyspesia. Methods Four groups of male SD rats( Ⅰ , Ⅱ , Ⅲ, Ⅳ , n =6 per group) were set in parallel design,the rats were given mosapride citrate, omeprazole, fluoxetine and combination of the three single doses,by intragastric administration. The determination of plasma samples were performed by a HPLC-MS/MS and the pharmacokinetic parameters were estimated(DAS 2.0). Results The Cmax and AUC of mosapride citrate,as well as omeprazole , were significantly increased; the AUC of hydrochlorid fluoxetine were increased, and CL/F of mosapride citrate, omeprazole and hydrochloride fluoxetine was decreased. Conclusion The results of preliminary study showed that there were obvious pharmacokinetic interactions among mosapride citrate,omeprazole and hydrochloride fluoxetine. The dosage of the three drugs was suggested to be reduced appropriately in their combination therapy.%目的 研究枸橼酸莫沙必利、奥美拉唑和盐酸氟西汀联合给药治疗大鼠功能性消化不良的药动学行为变化.方法 4组SD雄性大鼠分别为单药组枸橼酸莫沙必利(Ⅰ)、奥美拉唑(Ⅱ)、盐酸氟西汀(Ⅲ)和联合用药组(Ⅳ).采用HPLC-MS/MS法同时测定大鼠给药后不同时间点的血药浓度(DAS 2.0程序拟合),估算药动学参数.结果 枸橼酸莫沙必利、奥美拉唑与盐酸氟西汀均符合二室模型特征.三药合用时枸橼酸莫沙必利的Cmax和AUC显著增大,CL/F和V/F减小;奥美拉唑的Cmax和AUC显著增大,CL/F减小;盐酸氟西汀AUC增大,CL/F减小.结论 枸橼酸莫沙必利、奥美拉唑和盐酸氟西汀联合应用时存在明显的药代动力学叠加作用,建议临床联合用药时适当减量.

  6. Clinical Characteristics of Functional Dyspepsia Patients with Sleep Disorder%功能性消化不良伴睡眠障碍患者的临床特征

    Institute of Scientific and Technical Information of China (English)

    古巧燕; 张军

    2015-01-01

    背景:部分功能性消化不良(FD)患者常伴有睡眠障碍,生活质量受到严重影响。目的:探讨 FD 伴睡眠障碍患者的精神心理和生活质量。方法:选取2013年1月-2014年1月西安交通大学第二附属医院和延安大学附属医院门诊 FD 患者240例,根据匹兹堡睡眠质量指数将患者分为睡眠障碍组和无睡眠障碍组。采用 Zung 氏焦虑自评量表和抑郁自评量表、SF-36生活质量调查量表进行评定。结果:与无睡眠障碍组相比,睡眠障碍组的焦虑发病率(72.5%对40.8%)和抑郁发病率(65.0%对37.5%)均显著升高(P 0.05)。睡眠障碍组中青年、中年和老年患者的精神障碍发病率分别为50.0%、55.0%和80.0%,三者差异有统计学意义(χ2=8.10,P 0. 05). In patients with sleep disorder,the incidence of mental disorder was significantly different among young age group,middle age group and old age group(50. 0% ,55. 0% ,80. 0% ,respectively)(χ2 = 8. 10,P < 0. 05), and the incidence of mental disorder in male patients was significantly lower than that in female patients(32. 6% vs. 79. 2% ;χ2 = 25. 62,P < 0. 05). Conclusions:FD patients with sleep disorder has its own clinical characteristics. Study on the clinical characteristics of FD patients with sleep disorder could facilitate the effectiveness therapy,and has important significance in improving the quality of life.

  7. General Treatment

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009012 Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial. ZHU Liming(朱丽明), et al. Dept Gastroenterol, PUMC & CAMS, Beijing 100730. Chin J Intern Med 2008;47(11):910-913. Objective To investigate the efficacy and safety of compound azintamide on dyspepsia symptoms. Methods One hundred and eighty dyspepsia patients were divided into two groups

  8. The Changing Pattern of Upper Gastro-Intestinal Lesions in Southern Saudi Arabia: An Endoscopic Study

    OpenAIRE

    Al-Humayed Sulieman; Mohamed-Elbagir Ahmed; Al-Wabel Abdelhamid; Argobi Yahya

    2010-01-01

    Background/Aim: Dyspepsia is a common gastrointestinal disorder and is the most common indication for upper gastrointestinal endoscopy (UGIE). In recent years, it has been observed in several centers that there is a change in the causes of dyspepsia as revealed by UGIE. Our main objectives were: (1) To study the pattern of upper gastrointestinal pathology in patients with dyspepsia undergoing upper endoscopy; (2) Compare that with the pattern seen 10-15 years earlier in different areas of KS...

  9. Gangguan tidur pada anak dengan dispepsia fungsional dibandingkan anak tanpa dispepsia fungsional

    OpenAIRE

    Aldani, Noor Azrita

    2015-01-01

    Background. Functional dyspepsia, including epigastric pain associated with increased sleep disturbances. Objective. To compare sleep disturbances in children with and without functional dyspepsia Methods. A crossectional study were conducted at Al-Raudhatul Hasanah boarding school in Medan from March to April 2014. Subjects were children aged 8 to 18 years who were diagnosed with functional dyspepsia based on Rome III. Sleep disturbances in children assessed using Sleep Disturbance ...

  10. Kyoto global consensus report on Helicobacter pylori gastritis

    NARCIS (Netherlands)

    K. Sugano (Kentaro); J. Tack (Jan); E.J. Kuipers (Ernst); D.Y. Graham (David Y.); E. El-Omar; S. Miura (Soichiro); K. Haruma (Ken); M. Asaka (Masahiro); N. Uemura (Naomi); P. Malfertheiner

    2015-01-01

    textabstractObjective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate dia

  11. Observational study of the effects of dabigatran on gastrointestinal symptoms in patients with non-valvular atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Takeshi Yamashita, FJCC, MD, PhD

    2014-12-01

    Conclusions: The reported symptoms of dyspepsia were generally mild, but were moderate in approximately 10% of patients. Proton pump inhibitors, H2-receptor antagonists, and rebamipide seemed to be equally effective in relieving dabigatran-related dyspepsia (umin-CTR UMIN000007579.

  12. Kyoto global consensus report on Helicobacter pylori gastritis

    NARCIS (Netherlands)

    K. Sugano (Kentaro); J. Tack (Jan); E.J. Kuipers (Ernst); D.Y. Graham (David Y.); E. El-Omar; S. Miura (Soichiro); K. Haruma (Ken); M. Asaka (Masahiro); N. Uemura (Naomi); P. Malfertheiner; T. Azuma (Takeshi); F. Bazzoli (Franco); F.K.-L. Chan (Francis Ka-Leung); M. Chen (Minhu); N. Chiba (Naoki); T. Chiba (Tsutomu); L.G. Vas Coelho (Luiz Gonzaga); F. Di Mario (Francesco); K.M. Fock (Kwong Ming); Y. Fukuda (Yasuhiro); R.M. Genta (Robert Maximilian); K.-L. Goh (Khean-Lee); P.H. Katelaris (Peter Harry); M. Kato (Mototsugu); T. Kawai (Takashi); R. Kushima (Ryuji); V. Mahachai (Varocha); T. Matsuhisa (Takeshi); H. Miwa (Hiroto); K. Murakami (Kazunari); C. O'Morain (C.); M. Rugge (Massimo); K. Sato (Kiichi); T. Shimoyama (Tadashi); T. Sugiyama (Toshiro); H. Suzuki (Hidekazu); K. Yagi (Kazuyoshi); M.-S. Wu (Ming-Shiang); M. Ito (Masanori); N. Kim (Nayoung); T. Furuta (Takahisa); F. Mégraud (Francis); A. Shiotani (Akiko); T. Kamada (Tomonori)

    2015-01-01

    textabstractObjective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate

  13. Hubungan Derajat Keasaman Cairan Lambung dengan Derajat Dispepsia pada Pasien Dispepsia Fungsional

    Directory of Open Access Journals (Sweden)

    Emil Prasetyo Muhammad

    2016-08-01

    Full Text Available AbstrakHipersekresi asam lambung dianggap penting sebagai salah satu mekanisme patologis dispepsia fungsional. Hipersekresi asam lambung dapat meningkatkan sekresi pepsin yang dapat menimbulkan kerusakan mukosa lambung pada dispepsia fungsional. Tujuan penelitian ini adalah menentukan hubungan derajat keasaman cairan lambung dengan derajat dispepsia yang dialami pasien dispepsia fungsional. Penelitian ini merupakan studi analitik dengan disain cross sectional yang dilakukan pada 35 sampel pasien dispepsia fungsional dengan teknik consecutive sampling di RSUP DR. M.Djamil Padang mulai Juli sampai Oktober 2014. Analisis data dilakukan secara komputerisasi menggunakan uji chi-square. Hasil penelitian didapatkan 51.4% pasien dispepsia fungsional memiliki derajat keasaman cairan lambung hyperacidity, 57.1% menderita dispepsia derajat sedang-berat, dan menunjukkan hubungan yang cukup kuat dengan tarif signifikansi (p 0.029 (p < 0.05. Terdapat hubungan bermakna antara derajat keasaman cairan lambung dengan derajat dispepsia pada pasien dispepsia fungsional. Peningkatan derajat keasaman cairan lambung berbanding lurus dengan derajat dispepsia pada pasien dispepsia fungsional.Kata kunci: keasaman cairan lambung, derajat dispepsia, dispepsia fungsional AbstractGastric acid hypersecretion is considered important as one of the pathological mechanisms of functional dyspepsia. Gastric acid hypersecretion can increase the secretion of pepsin which can cause gastric mucosal damage in functional dyspepsia. The objective of this study was to determine the correlation of gastric juice acidity with dyspepsia level experienced by functional dyspepsia patients.This study was a analytic study with cross sectional design applied on 35 samples of functional dyspepsia patients with non-probability consecutive sampling technique at RSUP DR. M. Djamil Padang from July to October 2014. The data were computerized analyzed using chi-square test. The results showed 51.4% of

  14. Effect of a community screening for Helicobacter pylori: a 5-Yr follow-up study

    DEFF Research Database (Denmark)

    Hansen, Jane M; Wildner-Christensen, Mette; Hallas, Jesper;

    2008-01-01

    of community H. pylori screening and treatment on the prevalence of dyspepsia, and as secondary outcomes, the effect on dyspepsia-related health-care consumption and quality of life over 5 yr. METHODS: In 1998-1999, individuals aged 40-65 yr were randomized to H. pylori screening and treatment...... or to the control group. Five years later, the participants were sent a questionnaire to assess the prevalence of dyspepsia and quality of life. In addition, we obtained information from registers on the use of endoscopies and prescription medication. An economic evaluation was done alongside the randomized trial......, whereas no change was observed in the unscreened group; this rate remained constant during the next 4 yr. Quality of life did not change. A small effect was found for dyspepsia-related consultations and sick leave days, but not on the prescription rate of ulcer drugs. A 33% lower ulcer incidence (107...

  15. Thinking and Strategy on the Diagnosis and Treatment of Functional Gastrointestinal Disorders with Integrative Medicine

    Institute of Scientific and Technical Information of China (English)

    张声生

    2009-01-01

    The functional gastrointestinal disorders (FGIDs) are a group of diseases mainly manifested as gastrointestinal functional disorders,including 45 kinds of different diseases,such as functional dyspepsia(FD), irritable bowel syndrome (IBS),functional constipation

  16. P83

    Directory of Open Access Journals (Sweden)

    O. Ephimova

    2015-11-01

    Conclusion: The combination of nonspecific clinical signs (pain, dyspepsia with biochemical markers of biliary pathology and endocrine pancreatic insufficiency – of PCa patients demonstrates the obligatoriness of differential diagnostic pancreatic and biliary pathology in their earlier stages.

  17. Prevalence of chronic rhinosinusitis in children with dyspepsia–A cross sectional study

    Directory of Open Access Journals (Sweden)

    Mwangi Beatrice

    2016-11-01

    Conclusion: Chronic rhinosinusitis was diagnosed in more than 40% of children with dyspepsia. The odds of CRS being present in children diagnosed to have GERD increases significantly as demonstrated in this study.

  18. Talking about GI Disorders

    Science.gov (United States)

    ... Join eNewsletter Sidebar × MOBILE MENU About Us Upper GI Aerophagia Dyspepsia Cyclic Vomiting Syndrome Gastroparesis GERD Infant Regurgitation Rumination Syndrome Lower GI Bellyaches in Children Childhood Defecation Disorders Diarrhea Hirschsprung's ...

  19. Factors associated with gastro-duodenal disease in patients ...

    African Journals Online (AJOL)

    Factors associated with gastro-duodenal disease in patients undergoing ... recruit patients referred with upper gastro-intestinal symptoms for endoscopy. ... 64 had duodenal ulcer, 66 gastric ulcer, 27gastric cancer and 64 non-ulcer dyspepsia.

  20. The Surgical Management of Primary Hyperparathyroidism: The ...

    African Journals Online (AJOL)

    The Surgical Management of Primary Hyperparathyroidism: The Experience in ... the gastrointestinal system in the form of dyspepsia from Peptic ulcer disease and ... years from 2007-2014 and only three had complete medical documents.

  1. Relationship between helicobacter pylori infection and endoscopic ...

    African Journals Online (AJOL)

    Relationship between helicobacter pylori infection and endoscopic findings among patients with dyspepsia in north ... Sudan Journal of Medical Sciences ... Results: Of the 148 subjects studied, 68 (46.0%) were males and 80 (54.0%) females.

  2. Management of Helicobacter Pylori Infection

    African Journals Online (AJOL)

    Dr Olaleye

    related to age, socioeconomic class, and country of ... approach to management of patients with dyspepsia continues to evolve such ... success of antimicrobial therapy in clinical practice. It ..... Effective diagnostic and antimicrobial therapies.

  3. Download this PDF file

    African Journals Online (AJOL)

    User

    H. pylori. The purpose of this study was to compare the stool antigen (SAT) and immunoglobulin G (IgG) serology tests for ... Dyspepsia, stool antigen test, Helicobacter pylori, serology. > ..... bacterial infection in Africa: a random serological ...

  4. Vanda roxburghii: an experimental evaluation of antinociceptive properties of a traditional epiphytic medicinal orchid in animal models

    National Research Council Canada - National Science Library

    Uddin, Md Josim; Rahman, Md Masudur; Abdullah-Al-Mamun, Md; Sadik, Golam

    2015-01-01

    ...., an epiphytic orchid is widely distributed throughout Bangladesh. The root of this plant has a folkloric reputation to treat inflammations, fever, dyspepsia, bronchitis, hiccough, piles, snake bites, and diseases of the nervous system...

  5. Foundation and Clinical Research on the Effect of Traditional Chinese Herbs on Gastrointestinal Motility

    Institute of Scientific and Technical Information of China (English)

    李岩

    2009-01-01

    Gastric dyskinesis functional dyspepsia is a commonly clinical condition characterized as epigastric discomfort,distension after meals,early satiety and belching,which are commonly associated with the dysfunction of gastrointestinal motility.

  6. Download this PDF file

    African Journals Online (AJOL)

    Proff.Adewunmi

    Conclusion: In conclusion, the study provides enormous ethno-medicinal knowledge ... people of Pakistan, some medicinal plants need to be conserved for the future. ... to day life are stomach-aches, cramps, vomiting, dyspepsia, diarrhea and ...

  7. Original Research Original Research

    African Journals Online (AJOL)

    RAGHAVENDRA

    dyspepsia, bleeding piles, bronchitis, stomach disorde scabies and ... chitis, stomach disorders, blood and .... morbidity and mortality and the costs for the treatment. The natural ..... Pakistan Journal of Botany 47(4): 1575-1579. Karagöz, A.

  8. Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms.

    LENUS (Irish Health Repository)

    Quigley, E M M

    2013-03-01

    Gastrointestinal symptoms such as heartburn, indigestion (or dyspepsia), bloating, distension, constipation, abdominal pain, abdominal discomfort and diarrhoea are extremely common worldwide. For some, such symptoms can prove to be chronic and disabling.

  9. Upper Endoscopy

    Medline Plus

    Full Text Available ... Video Endoscopic Handling and Selection Document Link: The role of endoscopy in dyspepsia http://dx.doi.org/ ... GERD), Barrett's Esophagus and Ablation Therapies View more Media Backgrounders Members-only content Video Endoscopic Classification and ...

  10. 雷尼替丁、甲氧氯普胺和西沙必利治疗功能性消化不良上腹痛40例%Treating functionality dyspepsia epigastralgia by Ranitidine. Cisapride Tablet and Metoclopramide in 40 cases

    Institute of Scientific and Technical Information of China (English)

    朱丽美

    2005-01-01

    功能性消化不良是一种常见的临床征候群,其中多数患者是以上腹痛为主要症状。我们在1999年11月~2002年6月进行了雷尼替丁、甲氧氯普胺和西沙必利联合治疗功能性消化不良患者上腹痛的疗效观察。

  11. 参柴胃苏胶囊联合多潘立酮治疗功能性消化不良的临床疗效分析%The clinica efficacy of treatment of functional dyspepsia with combination of Senate Chai Weisu and capsule domperidone

    Institute of Scientific and Technical Information of China (English)

    王蓉辉; 张诗军

    2015-01-01

    目的:观察研究参柴胃苏胶囊与多潘立酮联合应用对功能性消化不良的临床治疗效果.方法:选取2014年4月~2015年4月于我科室就诊的诊断为功能性消化不良的患者60例,按随机数字表法分为治疗组和对照组各30例,治疗组给予参柴胃苏胶囊联合多潘立酮治疗,对照组单独应用多潘立酮治疗.治疗1月后记录两组疗效结果及主要症状变化情况.结果:治疗1月后治疗组主要症状餐后饱胀不适、早饱感上腹痛、上腹烧灼感评分分别为(1.32±0.73、1.83 ±0.56、1.22±0.75),均明显低于对照组(1.95±0.79、2.42±0.68、1.74 ±0.87).治疗1月后治疗组治HAMA/HAMD明显优于对照组;治疗组总有效率90.0%,明显高于对照组76.7%.治疗1月后治疗组治血清胃动素(MTL)及血清生长抑素(SS)水平分别为(218.7±41.2、613.6±52.1) pg/ml明显优于对照组(188.1±30.2、702.1±57.0) pg/ml.两组患者均无明显不良反应.结论:参柴胃苏胶裳联合多潘立酮治疗功能性消化不良,能明显改善患者症状.

  12. Effect of Fulinggancao Decoction on Gastric Liquid Emptying and Content of Nitric Oxide and Acetylcholine Esteras in the Gastric Antrum Tissue of Functional Dyspepsia Rats%茯苓甘草汤对功能性消化不良大鼠胃液体排空及胃窦一氧化氮及乙酰胆碱酯酶的影响

    Institute of Scientific and Technical Information of China (English)

    曹峰

    2009-01-01

    目的 观察茯苓甘草汤对功能性消化不良(FD)大鼠胃液体排空及胃窦中一氧化氮(NO)及乙酰胆碱酯酶(AChE)含量的影响,并探讨其可能的作用机制.方法 48只大鼠随机分为正常组、模型组、莫沙必利组及茯苓甘草汤组.采用盐酸灌胃模型,以硝酸还原酶法测定胃窦NO的含量,化学比色法测定胃窦AChE的含量.结果 茯苓甘草汤组大鼠胃内液体残留率低于模型组,与正常组比较无明显差别;茯苓甘草汤组较模型组可明显降低胃窦NO含量,增加胃窦AChE的含量.结论 茯苓甘草汤能显著促进FD大鼠胃液体排空,并且在增加胃窦部AChE含量的同时,胃窦部NO含量明显降低.提示茯苓甘草汤可能通过提高胃窦部AChE的含量,降低NO的含量的综合作用以改善FD大鼠胃液体排空延迟.

  13. Clinical Curative Effect of Buzhong Yiqi Granules Combined with Compound Azintamide in the Treatment of Stomach Sagging Associated Dyspepsia%补中益气颗粒联合复方阿嗪米特治疗胃下垂相关性消化不良的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    李迎春

    2014-01-01

    目的:观察补中益气颗粒联合复方阿嗪米特治疗胃下垂相关性消化不良的临床疗效。方法:对消化科门诊检查明确的胃下垂相关性消化不良患者,分别应用补中益气颗粒联合复方阿嗪米特(联合组)、单独应用补中益气颗粒(中药组)和单独应用多潘立酮(西药组)治疗组,疗程4周,观察治疗前、后的餐后饱胀不适、早饱、上腹部隐痛、上腹部烧灼感的积分变化,同时观察记录不良事件。结果:联合治疗组治疗后餐后饱胀不适、早饱的积分较中药组、西药组均有明显下降(P<0.01)。结论:补中益气颗粒联合复方阿嗪米特可以有效缓解胃下垂相关性消化不良患者的餐后饱胀不适、早饱等症状,改善食欲,可长期服用,且安全有效。%Objective:To observe the clinical effect of Buzhong Yiqi granules in combination with compound azintamide in treatment of stomach sagging correlation indigestion.Methods:The digest clinic to check patients gastroptosis digestive clear correlation, respectively using Buzhong Yiqi granules in combination with compound azintamide (combined group), single application of Buzhong Yiqi granules (TCM group) and single application of domperidone (Western medicine group) treatment group, the course of treatment for 4 weeks, the integral changes were observed before and after treatment, postprandial fullness discomfort, early satiety, epigastric pain, epigastric burning sensation, and observe the adverse events.Results:The combination therapy group after treatment of postprandial fullness discomfort, early satiety was integral is Chinese medicine group, western medicine group decreased (P<0.01).Conclusion:Yiqi granules in combination with compound azintamide can effectively alleviate gastroptosis associated dyspeptic patients with postprandial fullness discomfort, early satiety, improving appetite, long-term use, safe and effective.

  14. Prevalência da infecção por Helicobacter pylori e das lesões precusoras do câncer gástrico em pacientes dispéticos Prevalence of Helicobacter pylori infection and gastric cancer precursor lesions in patients with dyspepsia

    Directory of Open Access Journals (Sweden)

    Leandro Bizarro Muller

    2007-06-01

    Full Text Available RACIONAL: A infecção pelo Helicobacter pylori é fator importante no desenvolvimento da carcinogênese gástrica, mas somente uma fração dos pacientes infectados irá desenvolver câncer gástrico. A infecção pelo H. pylori determina gastrite crônica não-atrófica, que pode evoluir para gastrite atrófica e metaplasia intestinal e, finalmente, para displasia e adenocarcinoma. OBJETIVO: Estudar a prevalência da infecção pelo H. pylori e das lesões precursoras de câncer gástrico e sua associação, em pacientes submetidos a endoscopia digestiva alta em serviço de referência da região central do Estado do Rio Grande do Sul. MÊTODOS: Foram analisadas retrospectivamente biopsias de corpo e antro gástrico obtidas de pacientes submetidos a endoscopia digestiva alta no período entre 1994 e 2003, nas quais foi realizada pesquisa de H. pylori. As lâminas foram coradas pelo método da hematoxilina-eosina e os achados histológicos foram classificados de acordo com o sistema de Sydney em mucosa normal, gastrite crônica não-atrófica, gastrite atrófica e metaplasia intestinal. As alterações histológicas encontradas foram relacionadas com a presença de infecção pelo H. pylori. RESULTADOS: Biopsias de 2.019 pacientes foram incluídas no estudo. A idade média dos pacientes foi de 52 (±15 anos e 59% eram do sexo feminino. A pesquisa de H. pylori foi positiva em 76% dos pacientes. Mucosa normal, gastrite crônica não-atrófica, gastrite atrófica e metaplasia intestinal foram diagnosticadas em 5%, 77%, 3% e 15% das biopsias, respectivamente. A infecção por H. pylori determinou uma razão de chances 10 vezes (IC95% 6.50 - 17% maior de se encontrar algum grau de alteração histológica na mucosa gástrica. A razão de chances dos pacientes infectados apresentarem gastrite crônica não-atrófica, foi igual a 3 (IC95% 2,2 - 3,4. A razão de chances dos pacientes infectados apresentarem gastrite atrófica e metaplasia intestinal foi menor que 1. CONCLUSÃO: A prevalência da infecção por H. pylori foi alta (76% e os indivíduos infectados apresentaram probabilidade 10 vezes maior para a ocorrência de lesão da mucosa gástrica. Gastrite crônica não-atrófica apresentou prevalência de 77%, gastrite atrófica 3% e metaplasia intestinal 15%. A infecção pelo H. pylori determinou uma probabilidade 3 vezes maior para o desenvolvimento de gastrite crônica não-atrófica e não determinou risco para a ocorrência de gastrite atrófica e metaplasia intestinal, sugerindo que possivelmente outros fatores de risco, além do H. pylori, estejam envolvidos no processo da carcinogênese gástrica.BACKGROUND: Helicobacter pylori infection has been considered to play significant role in gastric carcinogenesis, but only a minority of people who harbor this organism will develop gastric cancer. H. pylori infection first causes chronic non atrophic gastritis. Chronic non atrophic gastritis may evolve to atrophic gastritis and intestinal metaplasia and finally to dysplasia and adenocarcinoma. AIMS: To estimate the prevalence of H. pylori infection and the precancerous gastric lesions and their relationship, in patients with dyspeptic symptoms who underwent upper gastrointestinal endoscopy at a reference center in the central region of Rio Grande do Sul state, Brazil. METHODS: We analyzed gastric biopsies taken from corpus and antrum of patients who underwent upper gastrointestinal endoscopy for H. pylori detection, between 1994 and 2003. According to Sydney system, chronic non atrophic gastritis, atrophic gastritis and intestinal metaplasia were diagnosed by histological examination (H-E stain. The histological diagnoses were related to H. pylori infection status. RESULTS: Biopsies from 2,019 patients were included in the study. Patients mean age was 52 (±15 and 59% were female. Seventy six percent had H. pylori infection. Normal mucosa, chronic non atrophic gastritis, atrophic gastritis and intestinal metaplasia were diagnosed in 5%, 77%, 3% and 15%, respectively. The OR for any degree of gastric mucosa lesion in infected patients was 10 (CI95% 6.50 - 17%. The OR for infected patients had chronic non atrophic gastritis was 3 (CI95% 2,2 - 3,4. The OR for infected patients had atrophic gastritis or intestinal metaplasia was less than 1. CONCLUSIONS: The prevalence of H. pylori infection in this population was high (76% and infected individuals had the probability 10 folds greater than non infected individuals to have any lesion of gastric mucosa. The prevalence of precancerous lesions was 77% for non atrophic chronic gastritis, 3% for atrophic gastritis and 15% for intestinal metaplasia. Infected patients had risk 3 folds greater than non-infected for the occurrence of non atrophic chronic gastritis. H. pylori infection did not show risk for occurrence of atrophic gastritis and intestinal metaplasia, suggesting that other risk factors should be involved in the carcinogenesis process.

  15. Pharmacoeconomics Evaluation after Being on the Market of Aspergillus Oryzae Enzyme and Pancreatin Tablet for Functional Dyspepsia%米曲菌胰酶片治疗功能性消化不良的上市后药物经济学评价

    Institute of Scientific and Technical Information of China (English)

    潘岳松; 杜忠东; 彭晓霞

    2012-01-01

    OBJECTIVE: To investigate the role of clinical pharmacist in drug therapy in pediatric department. METHODS: Disease course, drug therapy and outcomes were all described. The key points of pharmaceutical care of initial viral encephalitis treatment and anti-infective therapy for ventilator-associated pneumonia were analyzed as well as continuous intravenous administration. RESULTS: Clinical pharmacists provided reasonable medication suggestions in the treatment process of pediatric status epileptics and bacterial and fungal infection, which contributed to evaluating and dealing with adverse drug reaction during the treatment process. CONCLUSIONS: Pediatric clinical pharmacists join in treatment team and cooperate with clinical physicians to determine and adjust drug treatment programs to deal with adverse drug reactions and improve therapeutic efficacy.%目的:对米曲菌胰酶片治疗功能性消化不良的成本-效果进行分析.方法:收集多中心非随机同期病例数据,采用成本-效果分析对其进行药物经济学评价.结果:米曲菌胰酶片组相对于对照组(非米曲菌胰酶片治疗),每增加1个效果单位,成本可节约768.52元.使用米曲菌胰酶片治疗可通过提高治疗效果而降低病人的总费用.结论:米曲菌胰酶片治疗功能性消化不良有效、经济.

  16. Drug treatment

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    950229 A controlled multi—center clinical trial oncisapride in treatment of functional dyspepsia.WANGBaoen(王宝恩),et al.Beijing Friendship Hosp,Bei-jing.100050.Chin J Intern Med 1995;34(3):180—184.A controlled muhi-centre clinical trial was con-ducted for evaluating the efficacy and safety of cis-apride in the treatment of 414 cases of functional dys-pepsia with 169 cases as control.Cisapride were given

  17. Irritable Bowel Syndrome in a Population of African Patients

    Directory of Open Access Journals (Sweden)

    Sylvester Chuks Nwokediuko

    2012-01-01

    Full Text Available Background. Functional dyspepsia is the prototype functional gastrointestinal disorder. This study was designed to determine its prevalence, subtypes, and risk factors associated with the subtypes. Method. Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria. Results. Of 192 patients who had functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes accounted for 79.2%, 62.5%, and 50%, respectively. Multivariate analysis of the risk factors showed that independent predictors of postprandial distress syndrome were alcohol and irritable bowel syndrome while irritable bowel syndrome was independent predictor of epigastric pain syndrome. Alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs were independent predictors of cooccurrence of postprandial distress syndrome and epigastric pain syndrome. Conclusion. Functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients. Regarding symptomatology, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes account for 79.2%, 62.5%, and 50%, respectively. Risk factors for functional dyspepsia are irritable bowel syndrome, alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs.

  18. Hubungan Depresi dan Sindrom Dispepsia pada Pasien Penderita Keganasan Yang Menjalani Kemoterapi di RSUP DR. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Mona Rahmi Rulianti1

    2013-09-01

    Full Text Available AbstrakGangguan psikologi dan sindrom dispepsia (seperti mual dan muntah merupakan hal yang sering terjadi pada pasien kanker yang menjalani kemoterapi. Penelitian ini bertujuan untuk melihat hubungan depresi dengan sindrom dispepsia yang terjadi pada pasien keganasan yang menjalani kemoterapi. Metode penelitian ini menggunakan rancangan cross sectional dengan menggunakan kuisioner. Didapatkan pasien sebanyak 56 pasien keganasan yang menjalani kemoterapi di bangsal Penyakit Dalam, Bedah dan Obstetri & Ginekologi RSUP Dr. M. Djamil Padang selama 3 bulan (Desember 2012-Februari 2013. Depresi dinilai dengan wawancara menggunakan kuisioner BDI (Beck Depression Inventory II. Dispepsia dinilai dengan menggunakan kuisioner pedoman skor dispepsia. Data dianalisis dengan SPSS 17 menggunakan analisis korelasi bivariat Spearman. Koefisien korelasi untuk depresi dan sindrom dispepsia adalah 0,387. Kesimpulan akhir dari penelitian ini adalah ada hubungan yang cukup dan searah (p<0,01 antara depresi dan sindrom dispepsia yang terjadi pada pasien keganasan yang menjalani kemoterapi.Kata kunci: kanker, kemoterapi, depresi, sindrom dispepsiaAbstractPsychological disorders and dyspepsia syndromes (such as nausea and vomiting is a common thing in cancer patients undergoing chemotherapy. This study aims to examine the relationship of depression with dyspepsia syndrome that occurs in patients with malignancies who are undergoing chemotherapy. Methods this study uses cross-sectional design using questionnaires. Obtained for 56 patients who underwent chemotherapy malignancy patients in wards Internal Medicine, Surgery and Obstetrics & Gynecology in Hospital Dr. M. Djamil Padang for 3 months (December 2012-February 2013. Depression was assessed by interview using a questionnaire BDI (Beck Depression Inventory II. Dyspepsia assessed using questionnaires guidelines dyspepsia score. Data were analyzed with SPSS 17 using bivariate Spearman correlation analysis. The

  19. Frequency and risk factors of functional gastro-intestinal disorders in a rural Indian population.

    Science.gov (United States)

    Ghoshal, Uday C; Singh, Rajan

    2017-02-01

    As best estimates on functional gastrointestinal disorders (FGIDs) prevalence are expected from community studies, which are scanty from Asia, we evaluated the prevalence and risk factors of FGIDs in a rural Indian community. House-to-house survey was undertaken by trained interviewers using translated-validated Rome III and hospital anxiety and depression questionnaires. Among 3426 subjects ≥ 18 years old from 3 villages in Uttar Pradesh, 84% participated, of whom 80% were finally analyzed. Of these 2774 subjects (age 38.4 ± 16.5 years, 1573 [56.7%] male), 2654 [95.7%] were vegetarian and 120 [4.3%] non-vegetarian. Socioeconomic classes were upper (16.7%), upper middle (15.1%), lower middle (22%), upper lower (22.2%), and lower (24%) using Prasad's Classification; 603 (21.7%) had FGIDs (413 [14.9%] dyspepsia, 75 [2.7%] irritable bowel syndrome (IBS) and 115 [4.1%] dyspepsia-IBS overlap), by Rome III criteria. In subjects with dyspepsia, 49/528 (9%) had epigastric pain, 141 (27%) postprandial distress syndromes (EPS, PDS) and 338 (64%) EPS-PDS overlap. IBS was more often diarrhea than constipation-predominant subtype. On univariate analysis, chewing tobacco, aerated drink, tea/coffee, disturbed sleep, vegetarianism, and anxiety parameters and presence of dyspepsia predicting occurrence of IBS were associated with FGIDs. On multivariate analysis, chewing tobacco, aerated soft drink, tea/coffee, vegetarianism, anxiety parameters, and presence of dyspepsia predicting IBS were significant. Functional gastrointestinal disorders, particularly dyspepsia-IBS overlap, are common in rural Indian population; the risk factors included chewing tobacco, aerated soft drink, tea/coffee, vegetarian diet, disturbed sleep, anxiety, and dyspepsia predicting occurrence of IBS. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  20. From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons with Helicobacter pylori Associated Diseases

    Directory of Open Access Journals (Sweden)

    N Chiba

    2000-01-01

    Full Text Available In-depth meetings of the XIth International Workshop on Gastroduodenal Pathology and Helicobacter pylori led to the presentation and discussion of extensive new data on H pylori and its diseases. The mode of transmission of H pylori remains unclear, and it remains unknown why only a small proportion of infected individuals develop duodenal or gastric ulcer disease and even fewer develop gastric cancer. The role of H pylori eradication in persons with uninvestigated dyspepsia remains controversial. New clinical trials of H pylori treatment show symptom relief and improvement in the quality of life of persons with functional dyspepsia, especially in those with ulcer-like or reflux-like dyspepsia. Clearly the move is toward symptom-based management of persons with dyspepsia, with fewer endoscopies being needed in the otherwise healthy young dyspeptic patients. It remains controversial whether eradicating H pylori in duodenal ulcer or functional dyspepsia increases the risk of subsequent development of gastroesophageal reflux disease. The one-week proton pump inhibitor-based triple regimens remain the gold standard of H pylori therapy, but some of the ranitidine bismuth citrate plus two antibiotic regimens also achieve an 80% H pylori eradication rate on an intention-to-treat basis. While the urea breath test remains the noninvasive test of choice, interesting new data are available on the use of stool antigen testing to diagnose H pylori infection. The number of H pylori-associated gastroduodenal diseases grows to include possible liver, vascular, immune and skin conditions.

  1. Dispepsia ed Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Giovanni Fornaciari

    2003-09-01

    Full Text Available The effect of Helicobacter pylori (HP eradication on functional dyspepsia has been analysed in several clinical trials, including large, controlled and well-designed studies as well as small, flowed studies. The results of these studies indicate that HP infection does not play a major role in the aetiology of this disease and that HP eradication improves dyspeptic symptoms in no more than 15% of patients as compared to placebo. From a practical point of view 15 patients need to be treated for one to benefit while, in duodenal ulcer, 1.4 patient need to be treated for one to benefit. It remains to be elucidated if HP eradication in functional dyspepsia is useful to reduce the risk of developing organic dyspepsia (namely peptic ulcer in functional dyspepsia. In uninvestigated dyspepsia the management of HP infection in primary care has been fully debated.Two therapeutics strategies have been proposed: test and scope and test and treat. The value of test and treat strategy over alternative strategies has been demonstrated in several decision analyses. HP test and scope increases costs in primary care without improving symptoms and saves only 15% of endoscopies.

  2. Rikkunshito and ghrelin secretion.

    Science.gov (United States)

    Takeda, Hiroshi; Muto, Shuichi; Nakagawa, Koji; Ohnishi, Shunsuke; Asaka, Masahiro

    2012-01-01

    Rikkunshito is a kampo herbal medicine which is widely used in Japan for the treatment of the upper gastrointestinal symptoms of patients with functional dyspepsia (FD), gastroesophageal reflux disease (GERD), dyspeptic symptoms of postgastrointestinal surgery patients, and chemotherapy-induced dyspepsia in cancer patients. Recently, very unique characteristics of rikkunshito have been unveiled; oral administration of rikkunshito potentiates orexigenic action of ghrelin through several different mechanisms. In addition, several lines of evidence obtained from both animal and human studies indicate that rikkunshito can be an attractive and promising therapeutic option for the anorectic conditions including cisplatin-induced dyspepsia, anorexia of aging, stress-induced hypophagia, cancer cachexia-anorexia syndrome. In this review, we will highlight what is known about the orexigenic effect of rikkunshito with a special focus on an interaction with ghrelin signaling system.

  3. High prevalence of ulcer bleeding risk factors in dual antiplatelet-treated patients after percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Jensen, Berit Elin S; Hansen, Jane M; Junker, Anders B;

    2015-01-01

    . The following characteristics were considered risk factors: increasing age (age 60-69 years and ≥ 70 years); dyspepsia; previous peptic ulcer; use of non-steroidal anti-inflammatory drugs (NSAIDs) (weekly or daily), corticosteroids, selective serotonin reuptake inhibitors (SSRIs) and anticoagulants. RESULTS......: A total of 1,358 patients with a mean age of 64.1 years (range: 33-92 years) were included. The distribution of risk factors was as follows: dyspepsia: 681 patients (50.1%); previous ulcer: 110 (8.1%; 2.3% with bleeding); use of NSAIDs: 214 (15.8%); corticosteroids (2.9%), SSRIs (5.8%) and anticoagulants...

  4. Hubungan OAINS pada Pengobatan Dismenorea dengan Kejadian Dispepsia pada Mahasiswi Fakultas Kedokteran Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Siti Dwiaulia Risnomarta

    2015-05-01

    Full Text Available AbstrakDismenorea merupakan salah satu keluhan ginekologi tersering yang membawa pasien datang ke dokter. Dismenorea terjadi 40-80% dan 5-10% nya membutuhkan pengobatan. Obat anti inflamasi non steroid (OAINS paling sering digunakan untuk pengobatan dismenorea primer. Namun efek samping sering terjadi terutama pada saluran cerna. Tujuan penelitian ini adalah untuk mengetahui hubungan OAINS sebagai pengobatan dismenorea dengan kejadian dispepsia pada mahasiswi Fakultas Kedokteran Universitas Andalas. Rancangan penelitian adalah analitik cross-sectional. Subjek penelitian berjumlah 62 orang yang diambil dengan menggunakan metode total sampling. Dari penelitian ini diperoleh jumlah responden yang mengalami dispepsia sebanyak 14 orang (22,6%. Penelitian ini menilai OAINS (jenis,jumlah, dan kombinasi pada pengobatan dismenorea dengan kejadian dispepsia. Derajat dispepsia yang dikeluhkan umumnya ringan. Hasil uji chi-square antara jenis OAINS pada pengobatan dismenorea dan kejadian dispepsia didapatkan p = 0,120. Hasil uji chi-square antara jumlah OAINS pada pengobatan dismenorea dengan kejadian dispepsia didapatkan p = 1,00. Hasil uji chi-square antara kombinasi OAINS pada pengobatan dismenorea dengan kejadian dispepsia didapatkan p = 0,125. Berdasarkan hasil penelitian didapatkan bahwa tidak terdapat hubungan antara jenis, jumlah, dan kombinasi OAINS pada pengobatan dismenorea dengan kejadian dispepsia.Kata kunci: dismenorea, OAINS, dispepsia AbstractDysmenorrhea is one of most common gynecological complaint that bring the patients come to see doctor. Dysmenorrhea occurs 40-80% and 5-10% need treatment. Non-steroidal anti-inflammatory drugs (NSAIDs are the most common treatment for primary dysmenorrhea. The side effects of NSAIDs often occur, especially in gastointestinal. The objective of this study was to determine the relationship of NSAIDs in the treatment of dysmenorrhea and dyspepsia incident in female students of Faculty of Medicine of

  5. Gambaran Klinis dan Endoskopi Saluran Cerna Bagian Atas Pasien Dispepsia di Bagian RSUP Dr. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Citra Yuriana Putri

    2016-08-01

    Full Text Available AbstrakDispepsia ialah suatu sindrom yang terdiri dari nyeri atau rasa tidak nyaman di ulu hati, kembung, mual, muntah, sendawa, rasa cepat kenyang, perut rasa penuh/begah. Salah satu alat diagnostik untuk dispepsia adalah endoskopi. Alat ini dapat menentukan jenis lesi dan lokasi lesi pada saluran cerna atas pasien dispepsia. Tujuan penelitian ini adalah mementukan frekuensi keluhan, derajat keluhan, insiden pasien dispepsia yang mengalami tanda bahaya berdasarkan jenis kelamin, faktor risiko dispepsia, diagnosis endoskopi  dan lokasi lesi saluran cerna atas pasien dispepsia. Desain penelitian ini adalah deskriptif observasional. Subjek penelitian  terdiri dari 54 orang pasien dispepsia yang dilakukan pemeriksaan esofagogastroduodenoskopi (EGD di RSUP Dr. M. Djamil dari Mei hingga Juni 2014. Data dikumpulkan dengan cara pengisian kuisioner melalui wawancara, pencatatan hasil pemeriksaan endoskopi. Hasil penelitian didapatkan bahwa keluhan terbanyak dari pasien dispepsia adalah nyeri ulu hati (98,15%, derajat keluhan terbanyak adalah derajat sedang (38,89%, insiden tanda bahaya lebih banyak pada pria, faktor risiko terbanyak adalah konsumsi makanan berlemak (92,59%, diagnosis endoskopi dispepsia terbanyak adalah gastritis (61,11%, lokasi lesi saluran cerna atas terbanyak adalah gaster (85,19%. Kata kunci: dispepsia, gambaran klinis, endoskopi AbstractDyspepsia is a syndrome that consist of pain or discomfort in upper abdominal, bloating, nausea, vomiting, bletching, early satiation  and post-prandial fullness. One of the diagnostic tool for dyspepsia was endoscopy. It can be determined the type and the location of upper gastrointestinal’s lesions in patient with dyspepsia. The objective of this study was to determined the frequency of dyspepsia’s complaints, the degree of dyspepsia’s complaints, the incident of alarm sign based on gender, the frequency of  risk factors of dyspepsia, endoscopic diagnosis and the location of upper

  6.  Cost-effectiveness of medicine vs. endoscopy for dyspeptic patients

    DEFF Research Database (Denmark)

    Kjeldsen, Hans Christian; Lauritzen, Torsten; Christensen, Bo

      Background: Decision analyses conclude that empirical anti-secretory therapy is more cost-effective than endoscopy for managing patients with dyspepsia however RCTs including economic evaluation come to diverging results Aim: to compare the cost-effectiveness of two strategies for management of...

  7. Preoperative prediction model of outcome after cholecystectomy for symptomatic gallstones

    DEFF Research Database (Denmark)

    Borly, L; Anderson, I B; Bardram, L

    1999-01-01

    patients completed all questionnaires. Twenty-one patients continued to have abdominal pain after the operation. Patients with pain 1 year after cholecystectomy were characterized by the preoperative presence of a high dyspepsia score, 'irritating' abdominal pain, and an introverted personality...

  8. Upper Endoscopy

    Medline Plus

    Full Text Available ... Document Link: The role of endoscopy in dyspepsia http://dx.doi.org/10.1016/j.gie.2015.04.003 Document Link: Quality indicators for EGD http://dx.doi.org/10.1016/j.gie.2014. ...

  9. Giant Hiatal Hernia Which Causes Dyspnea

    Directory of Open Access Journals (Sweden)

    Muhammet Sayan

    2014-03-01

    Full Text Available Hiatal hernia refers to circumstance in which content of abdomen, especially stomach, herniate to through the esophageal hiatus into the mediastinum. Variable symptoms occur such as epigastric pain, dyspnea, dyspepsia. The indications for surgery, symptomatic patients which refractory to medical therapy, obstruction and bleeding.

  10. Browse Title Index

    African Journals Online (AJOL)

    Items 301 - 350 of 390 ... Vol 54, No 1 (2013), Risk factors, ulcer grade and management outcome of diabetic foot ulcers in a ... Andrew E Edo, Gloria O Edo, Ignatius U Ezeani .... Vol 54, No 2 (2013), That dyspepsia in the young could be cancer ...

  11. Treatment of Helicobacter pylori

    Institute of Scientific and Technical Information of China (English)

    Adam Harris

    2001-01-01

    @@ INTRODUCTION Using an evidence-based approach this review discusses the current treatment of Helicobacter pylori infection in patients with peptic ulcer disease, functional (non-ulcer)dyspepsia or gastro-oesophageal reflux disease (GORD).It also briefly addresses the potential role of eradication of H . pylori in preventing gastric cancer .

  12. Managing "Helicobacter Pylori" in College Health, with Special Considerations for International Students

    Science.gov (United States)

    Hillard, James Randolph; Kashup, Suman

    2016-01-01

    Objective: "Helicobacter pylori" infection is the major cause of dyspepsia, peptic ulcer disease, and gastric cancer. This paper will make specific recommendations for a diagnostic and treatment strategy tailored to the international student population. Participants/Methods: This paper is a case report and narrative review based on…

  13. NOD2/CARD15 genotype and common gastrointestinal diseases in 43 600 individuals

    DEFF Research Database (Denmark)

    Yazdanyar, S.; Nordestgaard, B.G.

    2010-01-01

    associate with risk of nine common gastrointestinal diseases. Design and setting. We genotyped 43 596 white individuals from the Danish general population followed for 31 years, during which time 782 developed oesophagitis and reflux, 1395 ulcus ventriculi and duodeni, 1384 gastritis and dyspepsia, 1407...

  14. Kyoto global consensus report on Helicobacter pylori gastritis and its impact on Chinese clinical practice.

    Science.gov (United States)

    Chen, Qi; Lu, Hong

    2016-06-01

    The Kyoto global consensus report on Helicobacter pylori (H. pylori) gastritis has had a great effect on the field of H. pylori studies worldwide. For the first time H. pylori gastritis was defined entirely as an infectious disease and H. pylori-associated dyspepsia as a new category of organic dyspepsia apart from functional dyspepsia, together with a proposed diagnostic algorithm. Accordingly, the report states that the eradication of H. pylori should be regarded as the first-line treatment for dyspepsia. Moreover, H. pylori eradication before the development of pre-neoplastic changes is recommended to reduce the risk of more serious complications of H. pylori gastritis. Despite the recommendations of this new global consensus, the task of transforming them into feasible and practical recommendations for individual countries will require them to become region-specific, which requires further discussion. © 2016 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

  15. Which test is best for Helicobacter pylori? A cost-effectiveness model using decision analysis.

    NARCIS (Netherlands)

    Elwyn, G.; Taubert, M.; Davies, S.; Brown, G.; Allison, M.; Phillips, C.

    2007-01-01

    GPs face a potential dilemma in deciding which test to use for detection of Helicobacter pylori. For patients with dyspepsia, the National Institute for Health and Clinical Excellence (NICE) advises primary care practitioners to adopt a 'test and treat' policy before considering a referral for gastr

  16. Upper Endoscopy

    Medline Plus

    Full Text Available ... of endoscopy in dyspepsia http://dx.doi.org/10.1016/j.gie.2015.04.003 Document Link: Quality indicators for EGD http://dx.doi.org/10.1016/j.gie.2014.07.057 Document Link: ASGE’s ...

  17. Which test is best for Helicobacter pylori? A cost-effectiveness model using decision analysis.

    NARCIS (Netherlands)

    Elwyn, G.; Taubert, M.; Davies, S.; Brown, G.; Allison, M.; Phillips, C.

    2007-01-01

    GPs face a potential dilemma in deciding which test to use for detection of Helicobacter pylori. For patients with dyspepsia, the National Institute for Health and Clinical Excellence (NICE) advises primary care practitioners to adopt a 'test and treat' policy before considering a referral for

  18. Managing "Helicobacter Pylori" in College Health, with Special Considerations for International Students

    Science.gov (United States)

    Hillard, James Randolph; Kashup, Suman

    2016-01-01

    Objective: "Helicobacter pylori" infection is the major cause of dyspepsia, peptic ulcer disease, and gastric cancer. This paper will make specific recommendations for a diagnostic and treatment strategy tailored to the international student population. Participants/Methods: This paper is a case report and narrative review based on…

  19. Evaluation of Gastrointestinal Motility in Awake Rats: A Learning Exercise for Undergraduate Biomedical Students

    Science.gov (United States)

    Souza, M. A. N.; Souza, M. H. L. P.; Palheta, R. C., Jr.; Cruz, P. R. M.; Medeiros, B. A.; Rola, F. H.; Magalhaes, P. J. C.; Troncon, L. E. A.; Santos, A. A.

    2009-01-01

    Current medical curricula devote scarce time for practical activities on digestive physiology, despite frequent misconceptions about dyspepsia and dysmotility phenomena. Thus, we designed a hands-on activity followed by a small-group discussion on gut motility. Male awake rats were randomly submitted to insulin, control, or hypertonic protocols.…

  20. Stress Management: A Handbook for Air Force Managers.

    Science.gov (United States)

    1986-09-01

    dyspepsia, frequent urination, headaches and migraine , neuroses, nightmares, insomnia, psychoses, psychosomatic disorder, diabetes mellitus, skin rash...Dietary control 5. Meditation and relaxation 6. Biofeedback 3-52 1% % % 7. Observing workers’ reaction to stressors 8. Recreational activity 9...of workplace stress reduction. x. Meditation is another form of stress reduction technique. Like physical exercise and relaxation exercise, it is used

  1. Cloninger's temperament and character traits in medical students of Korea with problem eating behaviors.

    Science.gov (United States)

    Lee, Soo Jin; Cloninger, C Robert; Chae, Han

    2015-05-01

    The personality profiles of patients with eating disorder have been extensively investigated, but those of people in the general population with eating behavior problems need to be evaluated to assess the relationship between personality, health behavior and level of overall well-being in non-clinical samples. Temperament and character traits, reasons for over-eating, and the negative influence of functional dyspepsia on quality of life were measured by the Temperament and Character Inventory (TCI), Dutch Eating Behavior Questionnaire (DEBQ), and Functional Dyspepsia Quality of Life (FDQOL) inventory, respectively, in 199 Korean medical students. The associations among TCI, FDQOL, DEBQ and body mass index (BMI) were examined by correlational analysis. Multiple regression analysis was carried out to measure how well personality (TCI) accounted for patterns of overeating (DEBQ) and impaired quality of life from functional dyspepsia (FDQOL). Individual differences in personality (especially harm-avoidance, self-transcendence, and self-directedness) were weakly associated with overeating and impaired quality of life from functional dyspepsia. Gender, social desirability and body mass index also played important roles in predicting eating behavior problems in the nonclinical population. We found that the personality traits observed in clinical patients with eating disorders are also found in people with eating behavior problems in the nonclinical population of Korea. The ways that personality traits affect eating behaviors were discussed along with recommendations for future studies in light of the limitations of available data. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Intestinal microbiota in functional bowel disorders: a Rome foundation report

    NARCIS (Netherlands)

    Simrén, M.; Barbara, G.; Flint, H.J.; Spiegel, B.M.; Spiller, R.C.; Vanner, S.; Verdu, E.F.; Whorwell, P.J.; Zoetendal, E.G.

    2013-01-01

    It is increasingly perceived that gut host-microbial interactions are important elements in the pathogenesis of functional gastrointestinal disorders (FGID). The most convincing evidence to date is the finding that functional dyspepsia and irritable bowel syndrome (IBS) may develop in predisposed in

  3. Drug: D07033 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07033 Formula, Drug Hangeshashinto extract (JP16); Hangeshashinto Pinellia tuber [...cer dyspepsia; Weak stomach; Hangover; Burp; Sour stomach; Stomatitis; Nervous disease Therapeutic category:... Chinese medicines D07033 Hangeshashinto extract (JP16) Traditional Chinese Medicine in Japan [BR:br08304] F...ormulas Formulas for stomach Antidiarrheal formulas D07033 Hangeshashinto PubChem: 51091375 ...

  4. Randomised clinical trial

    DEFF Research Database (Denmark)

    Meineche-Schmidt, V.; Christensen, E.; Bytzer, P.

    2011-01-01

    Background: Response to proton pump inhibitor (PPI) treatment in dyspepsia is unpredictable. Aim: To identify symptoms associated with response to esomeprazole in order to target patients for empirical treatment. Methods: Eight hundred and five uninvestigated, primary care patients with upper GI...

  5. Effects of Community Screening for Helicobacter pylori

    DEFF Research Database (Denmark)

    Bomme, Maria; Hansen, Jane Møller; Wildner-Christensen, Mette

    2017-01-01

    BACKGROUND & AIMS: Helicobacter pylori (Hp) eradication improves the prognosis of peptic ulcer disease (PUD), dyspepsia, and possibly gastric cancer. Hp screening tests are accurate and eradication therapy is effective. Hp population screening seems attractive. The aim of this study was to evaluate...

  6. Total pepsin activity and gastrin in sera as markers of eradication of Helicobacter pylori

    NARCIS (Netherlands)

    Khoshkholgh, M.; Saberi-Firoozi, M.; Fattahi, M.; Siavoshi, F.; Khatibian, M.; Vahedi, H.; Mikaeli, J.; Ansari, R.; Alizadeh, B.; Malekzadeh, R.; Massarrat, S.

    1994-01-01

    The measurement of total pepsin activity by colorimetry, and gastrin by radioimmunoassay method was performed on the sera of 100 patients (80 with duodenal ulcer and 20 with non-ulcer dyspepsia) before and 4 weeks after the end of antibacterial treatment for eradication of Helicobacter pylori. While

  7. Stomach and duodenum

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920683 The relationship between the fast-ing gastric bile acids and non-ulcer dyspep-sia. FENG Weihua(冯伟华), et al. Dept Bio-chemist, Changhai Hosp, 2nd Milit Med Coll.Shanghai 200433 Chin. J Digest 1992; 12(2):77-79. In the present study, the concentrations ofthe fasting gastric bile acid from 49 patients with

  8. Afprøvning af flydende, faerdigtilberedt modermaelkserstatning i Fyns Amt

    DEFF Research Database (Denmark)

    Kofoed, Poul-Erik; Engel, K; Kildeberg, P

    1990-01-01

    ), the parents' and visiting nurses' comments on the product, and the causes of "BD failure" (termination of BD feeding because of suspected cow's milk allergy, dyspepsia, etc.) were recorded as were rates of weight gain and linear growth. It is concluded that BD is a valuable alternative to existing powdered...

  9. Upper Endoscopy

    Medline Plus

    Full Text Available ... in dyspepsia http://dx.doi.org/10.1016/j.gie.2015.04.003 Document Link: Quality indicators for EGD http://dx.doi.org/10.1016/j.gie.2014.07.057 Document Link: ASGE’s assessment ...

  10. Which test is best for Helicobacter pylori? A cost-effectiveness model using decision analysis.

    NARCIS (Netherlands)

    Elwyn, G.; Taubert, M.; Davies, S.; Brown, G.; Allison, M.; Phillips, C.

    2007-01-01

    GPs face a potential dilemma in deciding which test to use for detection of Helicobacter pylori. For patients with dyspepsia, the National Institute for Health and Clinical Excellence (NICE) advises primary care practitioners to adopt a 'test and treat' policy before considering a referral for gastr

  11. Additional considerations for gastro-oesophageal reflux disease

    African Journals Online (AJOL)

    adopted in 2006.1 The aim of this global consensus definition ... and revolves around a patient-centred approach in which discrete ... described, and involve many thoroughly documented causes, such as ... effectiveness and presumable safety can be seen with the .... Truter I. An approach to dyspepsia for the pharmacist.

  12. Summary of an International and a Regional Symposium: Acid-Related Diseases - Improving Treatment Options

    Directory of Open Access Journals (Sweden)

    ABR Thomson

    1992-01-01

    Full Text Available The author examines the clinical impact of findings from a key international workshop on acid peptic disorders, “Appropriate acid suppression for the healing of acid-related diseases,” and from an important meeting which summarized results of a cross-Canada study of the symptomatic treatment of dyspepsia due to esophagitis and duodenal ulcer disease.

  13. Upper Endoscopy

    Medline Plus

    Full Text Available ... Document Link: The role of endoscopy in dyspepsia http://dx.doi.org/10.1016/j.gie.2015.04.003 Document Link: Quality indicators for EGD http://dx.doi.org/10.1016/j.gie.2014. ...

  14. Paediatric Rome III Criteria-Related Abdominal Pain Is Associated With Helicobacter pylori and Not With Calprotectin.

    Science.gov (United States)

    Sýkora, Josef; Huml, Michal; Siala, Konrad; Pomahačová, Renáta; Jehlička, Petr; Liška, Jiří; Kuntscherová, Jana; Schwarz, Jan

    2016-10-01

    Abdominal pain-related functional gastrointestinal disorders in children include functional dyspepsia, functional abdominal pain, irritable bowel syndrome, and abdominal migraine. We aimed to evaluate a possible association between functional abdominal pain disorders and Helicobacter pylori infection and faecal calprotectin level. Prospective observational study including consecutive children with functional gastrointestinal disorders fulfilling Rome III criteria (cases) and age/sex-matched healthy controls. H pylori has been detected by biopsy-based tests and stool-antigen detection, faecal calprotectin by enzyme-linked immunosorbent assay. A total of 56 cases (27 with functional dyspepsia) and 56 controls were enrolled. H pylori being detected in 17 of 56 cases (30.4%) and 4 of 56 controls (7.1%, odds ratio: 5.7; 95% confidence interval [CI]: 1.8-18.2, P = 0.003). H pylori was detected significantly more frequently in cases with functional dyspepsia (14/27, 51.9% odds ratio: 14.0; 95% CI: 3.9-49.7, P = 0.00001) than in controls and not in cases with other well-recognized functional gastrointestinal complaints (3/29, 10.3%). The median faecal calprotectin level was similar in cases (7.8 μg/g, 95% CI: 7.8-8.4) including those with gastritis, and controls (9.1 μg/g, 95% CI: 7.8-11.3). Gastritis features were more frequent in H pylori-infected and noninfected cases with functional dyspepsia (27/27, 100%) than in cases with other abdominal functional complaints (15/29, 51.7%, P = 0.007). H pylori gastritis and noninfectious gastritis were associated with functional dyspepsia in children referred for abdominal pain-related functional gastrointestinal disorders while faecal calprotectin is not a predictor of gastritis and is similar in children with functional abdominal pain symptoms and in controls.

  15. Hubungan Pola Makan dengan Kejadian Depresi pada Penderita Dispepsia Fungsional

    Directory of Open Access Journals (Sweden)

    Yuriko Andre

    2013-05-01

    Full Text Available AbstrakKetidakteraturan makan seperti kebiasaan makan yang buruk, tergesa-gesa, dan jadwal yang tidak teratur dapat menyebabkan dispepsia. Penderita depresi harus ditangani dengan sungguh-sungguh karena dikhawatirkan penderita depresi sangat tidak memperhatikan kesehatan dirinya seperti tidak mematuhi pola makan atau pola makannya menjadi tidak teratur. Penelitian ini bertujuan untuk mengetahui hubungan pola makan dengan kejadian depresi pada penderita dispepsia fungsional. Penelitian bersifat analitik dengan desain cross sectional. Subjek penelitian adalah 40 orang penderita dispepsia fungsional. Penelitian dilakukan di kota Padang dengan menggunakan data pasien dispepsia fungsional bulan Januari-Desember 2011. Pengumpulan data dilakukan pada periode Juni-November 2012 dan pengolahan data dilakukan dengan uji korelasi menggunakan sistem komputerisasi. Hasil penelitian didapatkan nilai peluang Odd Ratio (OR dengan Confidence Interval (CI 95% pada penderita depresi berpeluang sebesar 4.500 kali lebih besar memiliki pola makan tidak teratur dibandingkan dengan tidak depresi serta menunjukkan derajat hubungan yang cukup kuat dengan tarif signifikansi (p 0.025 (p < 0.05. Terdapat hubungan yang bermakna antara pola makan dengan kejadian depresi pada penderita dispepsia fungsional.Kata kunci: pola makan, depresi, dispepsia fungsionalAbstractIrregularity of meals as poor eating habits, unhurried, and irregular schedules may cause dyspepsia. Patients with depression should be treated seriously because it was feared people with depression do not pay attention to their own health so as not to comply with the diet or eating patterns become irregular. The aim of this study is to determine the relationship of diet to the incidence of depression in patients with functional dyspepsia. The research is analytic cross sectional design. The subjects were 40 people of functional dyspepsia patients. The study was conducted in the Padang City with functional

  16. Abdominal syndromes and functional ability in the elderly

    DEFF Research Database (Denmark)

    Kay, L; Avlund, K

    1994-01-01

    Data concerning a random cohort of 1,119 70-year-old subjects were analyzed to evaluate the association between Upper Dyspepsia and Irritable Bowel Syndrome and functional ability. Seven hundred and thirty-four subjects were interviewed about abdominal symptoms and were visited at home by an occu...... that abdominal syndromes are associated to functional ability, suggesting that there is a diffuse disorder affecting both smooth and striated muscles.......Data concerning a random cohort of 1,119 70-year-old subjects were analyzed to evaluate the association between Upper Dyspepsia and Irritable Bowel Syndrome and functional ability. Seven hundred and thirty-four subjects were interviewed about abdominal symptoms and were visited at home...

  17. Treating 12 cases of fever in children with simple food by abdominal massage%腹部按摩治疗小儿单纯性食积发热12例

    Institute of Scientific and Technical Information of China (English)

    张茂亮

    2013-01-01

    Children dyspepsia fever, is a common disease in pediatrics, the thermal potential not too high, on a low calorie, with stomach bloating, belching acid, do not think of eating, restless, restless sleep,not nearly clothing, poor stool symptoms, abdominal massage therapy, 12 patients with dyspepsia in children with fever were alleviated.%小儿食积发热,是当今小儿科的一种常见病,此病热势多不太高,以低热为主,多伴有肚腹胀热,嗳气酸腐,不思饮食,烦躁不安,睡眠不安,不近衣被,大便不畅诸症,经腹部按摩治疗,12例单纯性食积发热的患儿均得到了缓解。

  18. Managing Helicobacter pylori in college health, with special considerations for international students.

    Science.gov (United States)

    Hillard, James Randolph; Kashup, Suman

    2016-07-01

    Helicobacter pylori infection is the major cause of dyspepsia, peptic ulcer disease, and gastric cancer. This paper will make specific recommendations for a diagnostic and treatment strategy tailored to the international student population. This paper is a case report and narrative review based on recent international epidemiologic studies and consensus conference recommendations identified in MEDLINE. In the nations (mostly Asian) that send the largest number of students to the United States, the prevalence of H. pylori is generally 60% to 80%, whereas the prevalence in the United States is about 25%. The patterns of antibiotic resistance in those countries are also different than that in the general US population. Health care providers should have a higher index of suspicion for Helicobacter infection among international students with dyspepsia and need to use a different treatment regimen than is standard for the general US population.

  19. Helicobacter pylori and nonmalignant diseases.

    LENUS (Irish Health Repository)

    Alakkari, Alaa

    2012-02-01

    Research published over the past year has documented the continued decline of Helicobacter pylori-related peptic ulcer disease and increased recognition of non-H. pylori, non-steroidal anti-inflammatory drugs ulcer disease--idiopathic ulcers. Despite reduced prevalence of uncomplicated PUD, rates of ulcer complications and associated mortality remain stubbornly high. The role of H. pylori in functional dyspepsia is unclear, with some authors considering H. pylori-associated nonulcer dyspepsia a distinct organic entity. There is increasing acceptance of an inverse relationship between H. pylori and gastroesophageal reflux disease (GERD), but little understanding of how GERD might be more common\\/severe in H. pylori-negative subjects. Research has focused on factors such as different H. pylori phenotypes, weight gain after H. pylori eradication, and effects on hormones such as ghrelin that control appetite.

  20. Antacids, Altered Mental Status, and Milk-Alkali Syndrome

    Directory of Open Access Journals (Sweden)

    Simon C. Watson

    2012-01-01

    Full Text Available The frequency of milk-alkali syndrome decreased rapidly after the development of histamine-2 antagonists and proton pump inhibitors for the treatment of peptic ulcer disease; however, the availability and overconsumption of antacids and calcium supplements can still place patients at risk (D. P. Beall et al., 2006. Here we describe a patient who presented with altered mental status, hypercalcemia, metabolic alkalosis, and acute renal failure in the context of ingesting large amounts of antacids to control dyspepsia.

  1. Trachyspermum ammi

    OpenAIRE

    2012-01-01

    Trachyspermum ammi commonly known as ‘Ajwain’ is distributed throughout India and is mostly cultivated in Gujarat and Rajasthan. The fruit possesses stimulant, antispasmodic and carminative properties and is used traditionally as an important remedial agent for flatulence, atonic dyspepsia, diarrhea, abdominal tumors, abdominal pains, piles, and bronchial problems, lack of appetite, galactogogue, asthma and amenorrhoea. Medicinally, it has been proven to possess various pharmacological activi...

  2. Prospective Assessment of Chronic Multisymptom Illness Reporting Possibly Associated with Open-Air Burn Pit Smoke Exposure in Iraq

    Science.gov (United States)

    2012-06-01

    dioxide, sulfur dioxide, and polycyclic aromatic hydrocarbons are being released in the smoke from the fires, and many are known carcinogens and may cause...the first Gulf War with CMI were found to have a higher frequency of dyspepsia, hyper- tension, and metabolic syndrome compared with those deployed...recognized, as well as the possibility of other adverse health outcomes, including liver disease, thyroid dys- function, lipid disorders, neurotoxicity

  3. First-time urea breath tests performed at home by 36,629 patients

    DEFF Research Database (Denmark)

    Dahlerup, Søren; Andersen, Rikke Charlotte; Nielsen, Birgitte Sperling Wilms;

    2011-01-01

    , positive H. pylori declined over the time course of the study (women: 19.6% in 2003 to 17.6% in 2009, p H. pylori results than younger patients. CONCLUSIONS: A test......-and-treat system was possible to implement that allowed patients to perform UBTs at their homes. The results of the first-time UBTs demonstrated that approximately one of five patients who presented with dyspepsia in the clinical setting of Danish primary care was infected with H. pylori....

  4. Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease.

    OpenAIRE

    1993-01-01

    The hypothesis that non-secretors of ABO blood group antigens, a group shown to be more susceptible to certain bacterial infections, may be at greater risk of gastroduodenal disease because of increased susceptibility to Helicobacter pylori infection was investigated. Of 101 patients with symptoms of dyspepsia who were undergoing endoscopy, 32% were non-secretors (determined from Lewis blood group phenotype), 36% had endoscopically visible gastroduodenal disease (antral gastritis, gastric ulc...

  5. Hemorrhagic Encephalopathy From Acute Baking Soda Ingestion.

    Science.gov (United States)

    Hughes, Adrienne; Brown, Alisha; Valento, Matthew

    2016-09-01

    Baking soda is a readily available household product composed of sodium bicarbonate. It can be used as a home remedy to treat dyspepsia. If used in excessive amounts, baking soda has the potential to cause a variety of serious metabolic abnormalities. We believe this is the first reported case of hemorrhagic encephalopathy induced by baking soda ingestion. Healthcare providers should be aware of the dangers of baking soda misuse and the associated adverse effects.

  6. Chronic Biliary Pancreatitis Clinical Course Interrelation with Quality of Life and Patients Dependance on Supporting Therapy Indices

    Directory of Open Access Journals (Sweden)

    J.V. Listishenkova

    2009-06-01

    Full Text Available The analysis of clinical course influence on life quality and patients dependance on supporting therapy of chronic biliary dependent pancreatitis is represented. It has been determined that increase of life quality is in close correlation with exacerbation frequency, dyspepsia syndrome evidence and manifestations of exocrinous insufficiency of pancreas. Patients with chronic biliary dependent pancreatitis do not carry out doctor’s recommendations in appropriate manner.

  7. Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis

    Institute of Scientific and Technical Information of China (English)

    Nicole; Acosta; Andrés; Quiroga; Pilar; Delgado; María; Mercedes; Bravo; Carlos; Jaramillo

    2010-01-01

    AIM: To investigate Helicobacter pylori (H. pylori) CagA diversity and to evaluate the association between protein polymorphisms and the occurrence of gastric pathologies. METHODS: One hundred and twenty-two clinical isolates of H. pylori cultured from gastric biopsies obtained from Colombian patients with dyspepsia were included as study material. DNA extracted from isolates was used to determine cagA status, amplifying the C-terminal cagA gene region by polymerase chain reaction. One hundred and six strai...

  8. Dor abdominal crônica, dispepsia não ulcerosa e infecção pelo Helicobacter pylori em crianças e adolescentes

    OpenAIRE

    Silva, Renato Guilherme Silveira Corrêa [UNESP

    2014-01-01

    Aims: To investigate if the use of refined clinical characteristics of chronic abdominal pain can identify patients for further investigation of Helicobacter pylori (H. pylori) infection. An observational study on children and adolescents with chronic non-ulcer dyspepsia was performed to investigate the potential association between specific gastrointestinal symptoms and H. pylori infection. The hypothesis was that the use of demographics and clinical data with defined criteria for chronic ab...

  9. All Roads Lead to Rome: Update on Rome III Criteria and New Treatment Options

    OpenAIRE

    Shih, David Q.; Kwan, Lola Y.

    2007-01-01

    The recently published Rome III criteria reflect current understanding of functional gastrointestinal disorders. These criteria include definitions of these conditions and their pathophysiologic subtypes and offer guidelines for their management. At the 2006 Annual Scientific Meeting of the American College of Gastroenterology, a panel of experts discussed these criteria as they pertain to irritable bowel syndrome, functional dyspepsia, and chronic constipation. This article reviews the panel...

  10. Prevalence of dyspeptic symptoms and heartburn of adults in Belo Horizonte, Brazil

    Directory of Open Access Journals (Sweden)

    Alessandra Maciel ALMEIDA

    Full Text Available ABSTRACT BACKGROUND Medical literature has shown dyspepsia and heartburn-related symptoms occur among 15% to 40% of the population. These symptoms can occur at any age and are more prevalent in women. OBJECTIVE Investigate the prevalence of dyspeptic symptoms and heartburn among individuals over 18. METHODS Individuals over 18 were randomly selected in public venues in Belo Horizonte/MG to participate. A standardized questionnaire that included questions related to social-demographic characteristics, eating habits, digestive symptoms, medical appointments, medications, exams, previous surgeries and comorbidities was applied. A questionnaire about functional dyspepsia diagnosis (Rome III was also applied. RESULTS A total of 548 individuals were interviewed. Among these, 58.4% were women, 59.3% were white, 55.9% were single and the average age was 36 years. Within this group, 376 individuals (68.6% declared to have some symptom and/or use medication to relieve dyspepsia symptoms, and for these patients were applied the Rome III questionnaire. Based on the diagnostic criteria for the questionnaire proposed by the Rome III consensus, the symptom of postprandial fullness was reported by 6.7% of the individuals, early satiety (3.5% and epigastric pain (10.6%. The overlap of these symptoms was very frequent. The prevalence of functional dyspepsia was 10.6% (postprandial discomfort syndrome (8.2% and epigastric pain syndrome (2.4%. Among all participants, 52.5% reported heartburn, and 11.1% presented this symptom at least once a week. The most used drug was omeprazole. CONCLUSION The prevalence of dyspeptic symptoms and heartburn among a Brazilian adult urban population is similar to those described in other countries.

  11. Additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: results of a randomized phase II study (JORTC KMP-02)

    OpenAIRE

    Ohnishi, Shunsuke; Watari, Hidemichi; Kanno, Maki; Ohba, Yoko; Takeuchi, Satoshi; Miyaji, Tempei; Oyamada, Shunsuke; NOMURA, EIJI; Kato, Hidenori; Sugiyama, Toru; Asaka, Masahiro; Sakuragi, Noriaki; Yamaguchi, Takuhiro; Uezono, Yasuhito; Iwase, Satoru

    2017-01-01

    Objective Rikkunshito, an herbal medicine, is widely prescribed in Japan for the treatment of anorexia and functional dyspepsia, and has been reported to recover reductions in food intake caused by cisplatin. We investigated whether rikkunshito could improve chemotherapy-induced nausea and vomiting (CINV) and anorexia in patients treated with cisplatin. Methods Patients with uterine cervical or corpus cancer who were to receive cisplatin (50 mg/m2 day 1) and paclitaxel (135 mg/m2 day 0) as fi...

  12. Chronic gastrointestinal symptoms and quality of life in the Korean population

    Institute of Scientific and Technical Information of China (English)

    Jeong-Jo Jeong; Sok-Won Han; Kyu-Yong Choi; In-Sik Chung; Myung-Gyu Choi; Young-Seok Cho; Seung-Geun Lee; Jung-Hwan Oh; Jae-Myung Park; Yu-Kyung Cho; In-Seok Lee; Sang-Woo Kim

    2008-01-01

    AIM: To evaluate the prevalence of chronic gastroin-testinal symptoms and their impact on health-related quality of life (HRQOL) in the Korean population. METHODS: A cross-sectional survey, using a reliable and valid Rome 1I based questionnaire, was per-formed on randomly selected residents, between 18 and 69 years in age. All respondents were interviewed at their homes or offices by a team of interviewers. The impact of chronic gastrointestinal symptoms on HRQOL was assessed using the Korean version of the 36-item Short-Form general health survey (SF-36). RESULTS: Of the 1807 eligible subjects, 1417 (78.4%: male 762; female 655) were surveyed. Out of the respondents, 18.6% exhibited at least one chronic gastrointestinal symptom. The prevalence of gastro-esophageal reflux disease (GERD), defined as heart-burn and/or acid regurgitation experienced at least weekly, was 3.5% (95% CI, 2.6-4.5). The prevalence of uninvestigated dyspepsia, irritable bowel syndrome (IBS) and chronic constipation based on Rome Ⅱ cri-teria were 11.7% (95% CI, 10.1-13.5), 2.2% (95% CI, 1.5-3.1), and 2.6% (95% CI, 1.8-3.5) respectively. Compared with subjects without chronic gastrointesti-nal symptoms (n = 1153), those with GERD (n = 50), uninvestigated dyspepsia (n = 166) and IBS (n=31) had significantly worse scores on most domains of the SF-36 scales. CONCLUSION: The prevalence of GERD, uninvesti-gated dyspepsia and IBS were 3.5%, 11.7% and 2.2% respectively, in the Korean population. The health-related quality of life was significantly impaired in sub-jects with GFRD, uninvestigated dyspepsia and IBS in this community.

  13. Residual gallbladder stones after cholecystectomy: A literature review

    OpenAIRE

    Pradeep Chowbey; Anil Sharma; Amit Goswami; Yusuf Afaque; Khoobsurat Najma; Manish Baijal; Vandana Soni; Rajesh Khullar

    2015-01-01

    Background: Incomplete gallbladder removal following open and laparoscopic techniques leads to residual gallbladder stones. The commonest presentation is abdominal pain, dyspepsia and jaundice. We reviewed the literature to report diagnostic modalities, management options and outcomes in patients with residual gallbladder stones after cholecystectomy. Materials And Methods: Medline, Google and Cochrane library between 1993 and 2013 were reviewed using search terms residual gallstones, post-ch...

  14. Stem and leaf anatomy of Plectranthus neochilus Schltr., Lamiaceae

    OpenAIRE

    Márcia do Rocio Duarte; Juliano Ferreira Lopes

    2007-01-01

    Plectranthus neochilus Schltr. is an aromatic herb named " boldo" or " boldo-gambá" and employed for treating hepatic insufficiency and dyspepsia in folk medicine. This paper has investigated its stem and leaf anatomy, in order to contribute for the medicinal plant identification. The botanical material was prepared according to standard microtechniques. The stem has quadrangular transection and, in secondary growth at the level analyzed, shows uniseriate epidermis and numerous trichomes. The...

  15. Formulation and evaluation of meclizine hydro chloride mouth dissolving tablets: An attempt to enhance patient compliance

    OpenAIRE

    Nimisha; Pushplata Pal; Dipti Srivastava

    2012-01-01

    The purpose of this research work was to develop mouth dissolving tablets of Meclizine HCL by superdisintegrant addition and sublimation method. Meclizine HCl is an anti-emetic drug used for management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting. Sodium starch glycolate was used as super disintregrant and camphor used for enhancement of porosity of the tablets Disintegration time of tablets prepared by superdisintegrant addition were significantly less (P < 0.05) than prepa...

  16. Effects of Community Screening for Helicobacter pylori: 13-Year Follow-Up Evaluation of a Randomized Controlled Trial.

    Science.gov (United States)

    Bomme, Maria; Hansen, Jane Møller; Wildner-Christensen, Mette; Hallas, Jesper; Schaffalitzky de Muckadell, Ove B

    2017-06-09

    Helicobacter pylori eradication improves the prognosis of peptic ulcer disease (PUD), dyspepsia, and possibly gastric cancer. H pylori screening tests are accurate and eradication therapy is effective. H pylori population screening seems attractive. The aim of this study was to evaluate the long-term effect of H pylori population screening and eradication on dyspepsia prevalence and the incidence of PUD, and as secondary outcomes to assess the effect on health care consumption and quality of life. At baseline in 1998 to 1999, 20,011 individuals aged 40 to 65 years were randomized to H pylori screening and eradication or a control group with no screening. Both groups received a questionnaire on dyspepsia and quality of life. Register data were obtained for all randomized individuals. The baseline questionnaire response rate was 63%. Of the 5749 individuals screened, 1007 (17.5%) were H pylori positive. Complete symptom data were obtained for 8658 (69%) individuals after 13 years. Dyspepsia prevalence decreased in both groups during the follow-up period, but multivariate analysis showed no effect of H pylori screening and eradication (adjusted odds ratio, 0.93; 95% confidence interval, 0.82-1.04); compared with usual care. Intention-to-treat and per-protocol analyses of register data provided similar results. H pylori screening neither reduced PUD incidence significantly (adjusted odds ratio, 0.88; 95% confidence interval, 0.70-1.11) nor did it have a beneficial effect on health care consumption. H pylori screening had no long-term effect on quality of life. This randomized clinical trial with 13 years of follow-up evaluation, designed to provide evidence on the effect of H pylori population screening, showed no significant long-term effect when compared with usual care in this low-prevalence area. ClinicalTrials.gov identifier: NCT02001727. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

  17. Early effects of oral administration of omeprazole and roxatidine on intragastric pH

    OpenAIRE

    2012-01-01

    Objective: The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg. Methods:...

  18. The changing pattern of upper gastro-intestinal lesions in southern Saudi Arabia: An endoscopic study

    Directory of Open Access Journals (Sweden)

    Al-Humayed Sulieman

    2010-01-01

    Full Text Available Background/Aim: Dyspepsia is a common gastrointestinal disorder and is the most common indication for upper gastrointestinal endoscopy (UGIE. In recent years, it has been observed in several centers that there is a change in the causes of dyspepsia as revealed by UGIE. Our main objectives were: (1 To study the pattern of upper gastrointestinal pathology in patients with dyspepsia undergoing upper endoscopy; (2 Compare that with the pattern seen 10-15 years earlier in different areas of KSA. Materials and Methods: Retrospective study of all UGI endoscopies performed at Aseer Central Hospital, Abha, Southern Saudi Arabia during the years 2005-2007 on patients above 13 years of age. Patients who underwent UGIE for reasons other than dyspepsia were excluded. The analysis was performed using the SPSS 14 statistical package. Results: A total of 1,607 patients underwent UGI endoscopy during the three-year study period (age range, 15-100. There were 907 males (56.4% and 700 female (43.6%. Normal findings were reported on 215 patients (14% and the majority had gastritis (676 = 42%, of whom 344 had gastritis with ulcer disease. Moreover, 242 patients (15% had gastro-esophageal reflux (GERD, with or without esophagitis or hiatus hernia. Also, a total of 243 patients had duodenal ulcer (DU (15% while only 12 had gastric ulcer (0.7%. Discussion and Conclusion: There is clear change in the frequency of UGIE lesions detected recently compared to a decade ago with an increasing prevalence of reflux esophagitis and hiatus hernia. This could be attributed to changes in lifestyle and dietary habits such as more consumption of fat and fast food, increased prevalence of obesity, and smoking. These problems should be addressed in order to minimize the serious complications of esophageal diseases.

  19. Üst gastrointestinal sistem şikayetleri ile birinci basamağa başvuran kadınlarda gastroözofageal reflü semptomları ile gastroduodenal semptomlar örtüşür

    OpenAIRE

    TİFTİKÇİ, Arzu; Atuğ, Özlen; SEZİKLİ, Mesut; TÜRE, Filiz; Eren, Fatih; ALTURFAN, Ebru EMEKLİ; KIZILTAŞ, Şafak; Tözün, Nurdan; İmeryüz, Neşe

    2015-01-01

    Background and Aims: Functional dyspepsia, gastroesophageal reflux disease and peptic ulcer are common chronic diseases in the community. Different symptoms may sometimes be observed within these different groups of patients and this kind of overlap may create difficulties in the management and follow-up of these individuals. We aimed to determine the presence, frequency and severity of upper gastrointestinal system complaints and the range of overlapping symptoms among women who applied to p...

  20. Hemorrhagic Encephalopathy From Acute Baking Soda Ingestion

    Directory of Open Access Journals (Sweden)

    Adrienne Hughes

    2016-09-01

    Full Text Available Baking soda is a readily available household product composed of sodium bicarbonate. It can be used as a home remedy to treat dyspepsia. If used in excessive amounts, baking soda has the potential to cause a variety of serious metabolic abnormalities. We believe this is the first reported case of hemorrhagic encephalopathy induced by baking soda ingestion. Healthcare providers should be aware of the dangers of baking soda misuse and the associated adverse effects.

  1. Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

    Institute of Scientific and Technical Information of China (English)

    Krystyna Stec-Michalska; Slawomir Antoszczyk; Grazyna Klupinska; Barbara Nawrot

    2005-01-01

    AIM: To answer the question whether FHIT gene expression is affected by the family history of gastric carcinoma and the presence of Helicobacter pylori (Hpylori) in the gastric mucosa of patients with dyspepsia.METHODS: FHIT gene expression in two different topographic sites of the gastric mucosa of twenty-one patients with dyspepsia and with or without familial gastric carcinoma, infected or not infected with H pylori, was evaluated by reverse transcription-PCR (RT-PCR) and IMAGE QUANT methods. A rapid urease test and histopathological examination were used to determine H pylori colonization.RESULTS: In the gastric mucosa of patients with family histories of gastric carcinoma, the amount of FHIT protein mRNA was reduced down to 32%, and for patients with H pylori colonization, to 24% in comparison to controls with dyspepsia and without cancer in the family. FHIT expression was independent of the topography of specimens (corpus vsantrum), and for the control patients it was less sensitive to infection with H pylori. A considerable statistical difference in FHIT levels was observed in the gastric mucosa from the corpus of patients with family histories of gastric carcinoma in respect to H pylori colonization (P = 0.06). Macroscopic evaluation of the gastric mucosa demonstrated that pathologic changes classified according to the Sydney system had no significant influence on FHIT expression within each tested group of patients.CONCLUSION: Loss of FHIT expression was observed in patients with dyspepsia and family histories of gastric carcinoma, especially those infected with H pylori. Such results may constitute an early indication of the development of gastric carcinoma, which is associated with family factors including heredity and H pylori infection. The loss of the FHIT gene may serve as a marker for early diagnosis and prevention of gastric carcinoma, especially in context of early monitoring of H pylori infection in individuals with a record of familial stomach

  2. Elucidation of the Metabolic Network of Helicobacter pylori J99 and Malaysian Clinical Strains by Phenotype Microarray

    OpenAIRE

    Lee, Woon Ching; Goh, Khean Lee; Loke, Mun Fai; Vadivelu, Jamuna

    2016-01-01

    Abstract Background Helicobacter pylori colonizes almost half of the human population worldwide. H. pylori strains are genetically diverse, and the specific genotypes are associated with various clinical manifestations including gastric adenocarcinoma, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). However, our current knowledge of the H. pylori metabolism is limited. To understand the metabolic differences among H. pylori strains, we investigated four Malaysian H. pylori clinical ...

  3. Validation and results of a questionnaire for functional bowel disease in out-patients

    Directory of Open Access Journals (Sweden)

    Skordilis Panagiotis

    2002-05-01

    Full Text Available Abstract Background The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece. Methods This was a prospective study. Diagnosis was based on detailed clinical and laboratory evaluation. The questionnaire was tested on a pilot group of patients. Interviewer-administration technique was used. One-hundred-and-forty consecutive patients attending the out-patient clinic for the first time and fifty healthy controls selected randomly participated in the study. Reliability (kappa statistics and validity of the questionnaire were tested. We used logistic regression models and binary recursive partitioning for assessing distinguishing ability among irritable bowel syndrome (IBS, functional dyspepsia and organic disease patients. Results Mean time for questionnaire completion was 18 min. In test-retest procedure a good agreement was obtained (kappa statistics 0.82. There were 55 patients diagnosed as having IBS, 18 with functional dyspepsia (Rome I criteria, 38 with organic disease. Location of pain was a significant distinguishing factor, patients with functional dyspepsia having no lower abdominal pain (p Conclusions This questionnaire for functional bowel disease is a valid and reliable instrument that can distinguish satisfactorily between organic and functional disease in an out-patient setting.

  4. The clinical meaning of gastric-wall hyperactivity observed on sestamibi cardiac single-photon emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Cote, C.; Dumont, M. [Centre Hospitalier Universitaire de Quebec, Dept. of Nuclear Medicine, Quebec, Quebec (Canada)]. E-mail: christian.cote@chuq.qc.ca

    2004-06-01

    To evaluate prospectively the incidence and clinical meaning, if any, of gastric-wall hyperactivity observed on sestamibi cardiac single-photon emission computed tomography (SPECT). This phenomenon is completely different from the well-known intraluminal gastric reflux of sestamibi. A group of 819 patients who underwent sestamibi cardiac SPECT was studied from January 2000 to October 2000. Gastric-wall activity was graded qualitatively. Only patients with gastric-wall activity near or equivalent to their heart activity were considered for subsequent analysis. The medical records of patient candidates were reviewed, and their family physicians were asked to respond to a questionnaire by telephone when further information was needed. We identified 13 patients with significant gastric-wall hyperactivity, which was more intense on rest images. Our review of the clinical data shows that all these patients were suffering from dyspepsia and were taking gastric medication. These 13 cases were assigned to 3 groups: gastroesophageal reflux, chronic functional dyspepsia and nonspecific gastritis. Significant gastric-wall hyperactivity is an infrequent observation on sestamibi cardiac SPECT. Our results indicate that the presence of significant gastric-wall hyperactivity is associated with dyspepsia. It is important to realize that this gastric-wall hyperactivity by its proximity to the inferior myocardial wall could in some circumstances lead to either false-negative or false-positive findings, representing a diagnostic problem. Although infrequent, this situation could be avoided by proper quality control, including a systematic review of the raw cine data before reading the images. (author)

  5. Upper gastrointestinal symptoms in autoimmune gastritis: A cross-sectional study.

    Science.gov (United States)

    Carabotti, Marilia; Lahner, Edith; Esposito, Gianluca; Sacchi, Maria Carlotta; Severi, Carola; Annibale, Bruno

    2017-01-01

    Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features.Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria. Association between symptoms and anemia pattern, positivity to gastric autoantibodies, Helicobacter pylori infection, and concomitant autoimmune disease were evaluated.In total, 70.2% of patients were female, median age 55 years (range 17-83). Pernicious anemia (53.6%), iron deficiency anemia (34.8%), gastric autoantibodies (68.8%), and autoimmune disorders (41.7%) were present. However, 56.7% of patients complained of gastrointestinal symptoms, 69.8% of them had exclusively upper symptoms, 15.8% only lower and 14.4% concomitant upper and lower symptoms. Dyspepsia, subtype postprandial distress syndrome was the most represented, being present in 60.2% of symptomatic patients. Univariate and multivariate analyses showed that age gastritis is associated in almost 60% of cases with gastrointestinal symptoms, in particular dyspepsia. Dyspepsia is strictly related to younger age, no smoking, and absence of anemia.

  6. Upper gastrointestinal symptoms in autoimmune gastritis

    Science.gov (United States)

    Carabotti, Marilia; Lahner, Edith; Esposito, Gianluca; Sacchi, Maria Carlotta; Severi, Carola; Annibale, Bruno

    2017-01-01

    Abstract Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features. Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria. Association between symptoms and anemia pattern, positivity to gastric autoantibodies, Helicobacter pylori infection, and concomitant autoimmune disease were evaluated. In total, 70.2% of patients were female, median age 55 years (range 17–83). Pernicious anemia (53.6%), iron deficiency anemia (34.8%), gastric autoantibodies (68.8%), and autoimmune disorders (41.7%) were present. However, 56.7% of patients complained of gastrointestinal symptoms, 69.8% of them had exclusively upper symptoms, 15.8% only lower and 14.4% concomitant upper and lower symptoms. Dyspepsia, subtype postprandial distress syndrome was the most represented, being present in 60.2% of symptomatic patients. Univariate and multivariate analyses showed that age gastritis is associated in almost 60% of cases with gastrointestinal symptoms, in particular dyspepsia. Dyspepsia is strictly related to younger age, no smoking, and absence of anemia. PMID:28072728

  7. A school-based study with Rome III criteria on the prevalence of functional gastrointestinal disorders in Chinese college and university students.

    Science.gov (United States)

    Dong, Yan-Yan; Chen, Fei-Xue; Yu, Yan-Bo; Du, Chao; Qi, Qing-Qing; Liu, Han; Li, Yan-Qing

    2013-01-01

    Functional gastrointestinal disorders, including functional dyspepsia, irritable bowel syndrome and functional constipation are very common worldwide. This research aims to estimate the prevalence and associated factors involved in functional gastrointestinal disorders in Chinese college and university students using the Rome III criteria. A total of 5000 students from Shandong University in China were asked in January-May 2012 to complete questionnaires, including the Rome III questionnaire, hospital anxiety and depression scale, and negative life events scale. Based on the 4638 students who completed the questionnaire, the prevalence of functional dyspepsia, irritable bowel syndrome and functional constipation in college and university students of North China worked out to be 9.25%, 8.34% and 5.45% respectively. They were more frequent in female students. The factors of anxiety (OR 1.07; 95% CI 0.99 to 1.16, P=0.002<0.05) and depression (OR 0.55; 95% CI 0.15 to 1.05, P=0.045<0.05) indicated a high risk of causing irritable bowel syndrome. Functional dyspepsia, irritable bowel syndrome and functional constipation were common in college and university students of North China. Psychological disorders such as anxiety and depression provide significant risk factors for irritable bowel syndrome patients.

  8. A school-based study with Rome III criteria on the prevalence of functional gastrointestinal disorders in Chinese college and university students.

    Directory of Open Access Journals (Sweden)

    Yan-Yan Dong

    Full Text Available BACKGROUND: Functional gastrointestinal disorders, including functional dyspepsia, irritable bowel syndrome and functional constipation are very common worldwide. OBJECTIVE: This research aims to estimate the prevalence and associated factors involved in functional gastrointestinal disorders in Chinese college and university students using the Rome III criteria. METHODS: A total of 5000 students from Shandong University in China were asked in January-May 2012 to complete questionnaires, including the Rome III questionnaire, hospital anxiety and depression scale, and negative life events scale. RESULTS: Based on the 4638 students who completed the questionnaire, the prevalence of functional dyspepsia, irritable bowel syndrome and functional constipation in college and university students of North China worked out to be 9.25%, 8.34% and 5.45% respectively. They were more frequent in female students. The factors of anxiety (OR 1.07; 95% CI 0.99 to 1.16, P=0.002<0.05 and depression (OR 0.55; 95% CI 0.15 to 1.05, P=0.045<0.05 indicated a high risk of causing irritable bowel syndrome. CONCLUSION: Functional dyspepsia, irritable bowel syndrome and functional constipation were common in college and university students of North China. Psychological disorders such as anxiety and depression provide significant risk factors for irritable bowel syndrome patients.

  9. Pharmacotherapy of gastroparesis.

    LENUS (Irish Health Repository)

    Quigley, E M

    2012-02-03

    The evaluation and management of gastric motor dysfunction continues to represent a significant clinical challenge. The very definition of what constitutes a clinically relevant disturbance of gastric motility remains unclear. The spectrum of gastroparesis extends from those with classical symptoms and severe delay of gastric emptying to those with dyspepsia and a mild delay in emptying rate. Indeed, for many patients with dyspepsia, the role of gastric emptying delay in the pathogenesis of symptoms, remains unclear. Any assessment of the efficacy of any therapeutic class in gastroparesis must be mindful, therefore, of these variations in definition. For those individuals with severe established gastroparesis, therapeutic success often remains elusive and i.v. erythromycin and oral dopamine antagonists, or substituted benzamides, remain the best options for acute severe exacerbations and chronic maintenance therapy, respectively. Alternatives, currently under investigation, include a number of 5-HT4 agonists, macrolides devoid of antibiotic activity, CCK antagonists and gastric electrical stimulation. Other novel approaches include strategies to address some of the regional abnormalities in gastric motor function that have been identified in some patients with dyspepsia.

  10. [Functional gastrointestinal disorders].

    Science.gov (United States)

    Vogt, W

    2007-11-21

    Functional gastrointestinal disorders particularly dyspepsia an irritable bowel syndrome are frequent problems for the general practitioner and also for the specialist. Both are diseases and not only a kind of discomfort. The high frequency of dispepsia and irritable bowel syndrome induces very high direct and indirect charges. Both diseases depend on a number of factors or causes, for whom the evidence is not good. But there are good experimental data for the visceral hypersensitivity as one of the main factors. Gastroscopy is the most important examination in the diagnosis of dyspepsia. Endoscopy has to be done in all patients with alarm symptoms an in all patients older than 45 years. The therapy of dyspepsia is an empirical one. The eradication of Helicobacter pylori is a therapeutical option, but only 8% of the patients will have benefit for a long time. Other therapeutical options are the use of proton-pump inhibitors, prokinetics or phytotherapeutics. The therapy of the irritable bowel syndrome depends on the subtype of the disease (diarrhea, constipation, abdominal pain, bloating). First of all a good doctor-patient relationship is mandatory. Furthermore the use of dietary fibre, antidiarrhoeics, laxatives and muscle relaxants may be beneficial. And phytotherapeutics can be an additional therapeutic approach.

  11. Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet.

    Science.gov (United States)

    Silvester, Jocelyn A; Graff, Lesley A; Rigaux, Lisa; Bernstein, Charles N; Leffler, Daniel A; Kelly, Ciarán P; Walker, John R; Duerksen, Donald R

    2017-07-07

    Celiac disease and functional intestinal disorders may overlap, yet the natural history of functional symptoms in patients with celiac disease is unknown. To investigate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), and functional bloating (FB) symptoms among patients with celiac disease at diagnosis and during the first year of a gluten-free diet. Adults with a new diagnosis of celiac disease were surveyed at baseline, 6 months and 1 year using standardized measures for intestinal symptoms [Rome III diagnostic questionnaire and celiac symptom index (CSI)] and gluten-free diet adherence [gluten-free eating assessment tool (GF-EAT) and celiac diet adherence test]. At diagnosis, two-thirds fulfilled Rome III diagnostic questionnaire symptom criteria for IBS (52%), functional dyspepsia (27%), and/or functional bloating (9%). One year post-diagnosis, there was high adherence to a gluten-free diet as 93% reported gluten exposure less than once per month on the GF-EAT and only 8% had ongoing celiac disease symptoms (CSI score >45). The rates of those meeting IBS (22%) and functional dyspepsia (8%) symptom criteria both decreased significantly on a gluten-free diet. The prevalence of functional symptoms (any of IBS, FD or FB) at 1 year was 47%. Long-term follow-up of patients with celiac disease is necessary because many patients with celiac disease who are adherent to a gluten-free diet have persistent gastrointestinal symptoms.

  12. Comparison of Serological and Biopsy Diagnostic Tests for Helicobacter Pylori in Dyspeptic Patients

    Directory of Open Access Journals (Sweden)

    Hamid Vahedi

    2015-04-01

    Full Text Available Introduction: Helicobacter pylori infection is a major cause of chronic gastritis, peptic ulcers and gastric cancer in humans. By using inexpensive laboratory methods for diagnosis of H. pylori infection several complications can be prevented. This study compared two methods including, histology and serology tests for diagnosis of H. pylori in patients with dyspepsia which has been conducted in 2012. Methods: 395 patients with dyspepsia which referred to Imam Hossein hospital of Shahroud were participated in this study. All patients undergoing endoscopic procedures and 6 standard biopsy specimens were taken for histological examination. Giemsa stain used for histological detection of H. pylori in gastric biopsy specimens serology. H. pylori IgG ELISA method was also performed to measure IgG titers against H. pylori. Data were statistically analyzed and the sensitivity, specificity, positive and negative predictive values were calculated. Results: From 395 patients with dyspepsia, serological test were positive in 212 patients (53.7%, histological test were positive in 316 (80% patients including 178 male patients (56.3% and 138 female patients sensitivity and specificity were 63.9%, and 87.3% respectively. Moreover positive predictive value was 95.3% and negative predictive value was 37.7%. Conclusion: Due to the high specificity and the relative sensitivity of serological tests as well as simplicity, speed and low cost of these testin comparison with other diagnostic methods these tests could be, recommended for screening.

  13. Adding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple Sclerosis

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    David J. Levinthal

    2013-01-01

    Full Text Available Background. Multiple sclerosis (MS patients often suffer from gastrointestinal (GI symptoms. However, the full extent and prevalence of such symptoms are not clearly established. Thus, we sought to define the prevalence of GI symptoms and syndromes in those with MS. Methods. 218 MS patients completed self-reported demographic and clinical data questionnaires as well as several standardized surveys probing MS severity and GI health. Results. Nearly two thirds (65.6% of patients endorsed at least one persistent GI symptom. Constipation (36.6%, dysphagia (21.1%, and fecal incontinence (15.1% were common. Surprisingly, nearly 30% (28.4% of the patients reported dyspeptic symptoms. Using validated diagnostic algorithms, patients met criteria for functional dysphagia (14.7%, functional dyspepsia (16.5%, functional constipation (31.7%, and IBS (19.3%, among others. Functional dysphagia, functional dyspepsia, and IBS were significantly more common in those with self-identified mood disorders. Conclusions. Constipation, fecal incontinence, and dysphagia are indeed frequent symptoms seen in MS patients. We also noted a ~30% prevalence of dyspepsia in this population. The mechanisms driving this association are not clear and require further study. However, due to this high prevalence, dyspeptic symptoms should be incorporated into the routine assessment of MS patients and, if found, may warrant collaborative referral with a GI specialist.

  14. Karakteristik Penderita Dispepsia Fungsional yang Mengalami Kekambuhan di Bagian Ilmu Penyakit Dalam RSUP Dr. M. Djamil Padang, Sumatera Barat Tahun 2011

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    Yui Muya

    2015-05-01

    Full Text Available AbstrakDispepsia merupakan salah satu masalah kesehatan yang sering ditemui dokter dalam praktek sehari-hari. Prevalensi dispepsia fungsional di Inggris mencapai 23,8%, sedangkan di Amerika Serikat 15%. Di Indonesia belum terdapat prevalensi penyakit ini secara keseluruhan. Tujuan penelitian ini adalah untuk mengetahui karakteristik penderita dispepsia yang mengalami kekambuhan di RSUP Dr. M. Djamil Padang, Sumatera Barat tahun 2011. Penelitian ini bersifat deskriptif dengan desain cross sectional. Populasi sebanyak 63 data penderita tetapi sampel yang memenuhi syarat hanya 42 penderita. Proporsi tertinggi penderita dispepsia adalah kelompok umur 46-55 tahun (38,1%, jenis kelamin perempuan (64,3%, suku minang (97,6%, agama Islam (100%, tingkat pendidikan akademik/PT (50,0%, pekerjaan ibu rumah tangga (35,7%, dan status telah kawin (71,4%. Kepada praktisi kesehatan atau dokter lini pertama agar dapat memaksimalkan usaha-usaha promosi kesehatan, sehingga masyarakat mendapat pengetahuan terutama mengenai sindrom dispepsia fungsional.Kata kunci: dispepsia fungsional, karakteristik penderita, kekambuhan AbstractDyspepsia is one of the common health problems that found by the doctors in daily practice. Prevalence rate of functional dyspepsia in the England is about 23.8% while in United Stated is about 15%. In Indonesia, there has been no overall disease prevalence. The objective of this study was to investigate the characteristics of hospitalized patients with dyspepsia who have a relapse at Dr M. Djamil Hospital Padang, West Sumatra in 2011. This study uses descriptive cross sectional design. Population data were 63 patients but only 42 samples were taken. The highest proportion of dyspeptic patients was 46-55 years age group (38.1%, female (64.3%, ethnic Minang (97.6%, Moslem (100%, education level Academic (50.0%, Housewife (35.7%, and Married (71.4%. Health practitioners or physician in order to maximize the health promotion efforts, so that

  15. No significant association between halitosis and upper gastrointestinal endoscopic findings: a prospective study

    Institute of Scientific and Technical Information of China (English)

    Adnan Tas; Seyfettin K(o)klü; (I)lhami Yüksel; (O)mer Ba(s)ar; Erdem Akbal; Ahmet Cimbek

    2011-01-01

    Background Previous studies have focused on the relationship between halitosis,gastroesophageal reflux disease and Helicobacter pylori.In this study we aimed to investigate the interaction between halitosis and upper gastrointestinal endoscopic findings.Methods Patients who previously had dyspepsia and had undergone endoscopic examination were included in the study.Symptoms of dyspepsia were investigated by means of a questionnaire that investigated halitosis.Patients who suffered from objective halitosis (confirmed by questions both to the patient and their relatives) were further investigated.Patients with known local or systemic causes of halitosis or structural disorders at endoscopy were excluded.Results The study included 358 patients (121 men and 237 women) with dyspeptic symptoms.The patients with and without halitosis had mean ages of (39.4+13.5) and (43.1±14.9) years,respectively.Patients without halitosis were significantly older than those in the halitosis group (P <0.05).Patients in the halitosis group had significantly higher frequencies of regurgitation,bloating and nausea (P <0.05) when compared to patients without halitosis.Endoscopic findings,including esophagitis,open cardia,hiatal hernia,gastritis and duodenitis,were comparable in the two groups.Conclusions The frequency of halitosis was high in patients with dyspepsia who underwent upper gastrointestinal endoscopy.Halitosis had a close relationship with several upper gastrointestinal symptoms,including regurgitation,nausea and bloating.There was no significant association between upper gastrointestinal endoscopic findings and halitosis.

  16. Kyoto global consensus report on Helicobacter pylori gastritis.

    Science.gov (United States)

    Sugano, Kentaro; Tack, Jan; Kuipers, Ernst J; Graham, David Y; El-Omar, Emad M; Miura, Soichiro; Haruma, Ken; Asaka, Masahiro; Uemura, Naomi; Malfertheiner, Peter

    2015-09-01

    To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate diagnostic assessment of gastritis and (4) when, whom and how to treat H. pylori gastritis. Twenty-three clinical questions addressing the above-mentioned four domains were drafted for which expert panels were asked to formulate relevant statements. A Delphi method using an anonymous electronic system was adopted to develop the consensus, the level of which was predefined as ≥80%. Final modifications of clinical questions and consensus were achieved at the face-to-face meeting in Kyoto. All 24 statements for 22 clinical questions after extensive modifications and omission of one clinical question were achieved with a consensus level of >80%. To better organise classification of gastritis and duodenitis based on aetiology, a new classification of gastritis and duodenitis is recommended for the 11th international classification. A new category of H. pylori-associated dyspepsia together with a diagnostic algorithm was proposed. The adoption of grading systems for gastric cancer risk stratification, and modern image-enhancing endoscopy for the diagnosis of gastritis, were recommended. Treatment to eradicate H. pylori infection before preneoplastic changes develop, if feasible, was recommended to minimise the risk of more serious complications of the infection. A global consensus for gastritis was developed for the first time, which will be the basis for an international classification system and for further research on the subject. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women

    Directory of Open Access Journals (Sweden)

    Gina Ferrer Poveda

    2014-07-01

    Full Text Available Objective: the aim of this research was to determine the prevalence of Helicobacter pylori infection on Chilean pregnant women and its relationship with the appearance and severity of hyperemesis and dyspepsia. Methods: quantitative study of prevalence in a transversal cut with variable analysis. The sample was taken from 274 Chilean pregnant women from the Bío Bío province through vein puncture between June and December, 2005. Pregnant women were informed of this study, interviewed and signed an informed consent. The samples were processed using ImmunoComb II Helicobacter pylori IgG kit. Statistical analysis was performed by means of the Statistical Package for Social Sciences (SPSS Program. Results: out of the total number of pregnant women, 68.6% showed infection by Helicobacter pylori. 79.6% of the total sample had symptoms of dyspepsia, and 72.5% of this group presented Helicobacter pylori infection. 12.4% showed pregnancy hyperemesis; among them, 79.4% were infected with Helicobacter pylori. 73.4% of the pregnant women that showed gastric discomfort during the first three months had Helicobacter pylori infection. 53.7% of them continued with gastric discomfort after the first three months; of those, 95.8% were infected. Helicobacter pylori infection was present only in 1.5% of pregnant women without gastric discomfort. Conclusion: both, gastric discomfort of pregnant women and the continuity of severe symptoms of dyspepsia and hyperemesis after the first three months of gestation are significantly correlated with Helicobacter pylori infection.

  18. Antibacterial activity of Boesenbergia rotunda (L. Mansf. and Myristica fragrans Houtt. against Helicobacter pylori

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    Gail Mahady

    2006-03-01

    Full Text Available Helicobacter pylori, a gram-negative bacterium, is recognized as the primary etiological agent for the development of gastritis, dyspepsia, peptic ulcer as well as gastric and colon cancer. In developing countries the incidence of H. pylori infection ranges from 50-100%. Two Thai plants, namely Boesenbergia rotunda (L.Mansf. and Myristica fragrans Houtt., have been used to treat dyspepsia and peptic ulcer in Thai Traditional Medicine. Their crude extracts were previously reported to possess anti- H. pylori activity. This investigation proposed to test previously isolated bioactive compounds from B. rotunda and M. fragrans if they possessed anti- H. pylori activity. Primary cultures of H. pylori from local hospital patients in Thailand were used in the investigation. In vitro anti- H. pylori testing had been performed with pinostrobin and red oil from roots of B. rotunda, and dihydroguaiaretic acid from arils of M. fragrans. Clarithromycin (MIC 120 µg/mL was used as a positive control. All three compounds showed positive clear zone in agar diffusion test at p<0.05 in all 10 clinical cultures. Pinostrobin, red oil and dihydroguaiaretic acid autoclaved in blood agar medium had MIC of 125, 150, 100 µg/mL and MBC of 150, 175, 125 µg/mL, respectively. All three compounds have their activities against H. pylori in the same range of that of drug currently used in the treatment of peptic ulcer. Thus, all three compounds from B. rotunda and M. fragrans show good potential for further drug development. This investigation demonstrates that food and spice plants used in Thai Traditional Medicine for treatment of dyspepsia and peptic ulcer contain compounds which inhibit the growth of H. pylori in vitro. The result suggests that ingredients of some Thai food in regular diet may contribute to the low incidence of gastric cancer in the Thai population by affecting the growth of H. pylori.

  19. Nonalcoholic fatty liver may increase the risk of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.

    Science.gov (United States)

    Basaranoglu, Metin; Canbakan, Billur; Yildiz, Kemal; Ceylan, Bahadir; Baysal, Birol; Uysal, Omer; Senturk, Hakan

    2016-10-01

    Fatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives. In this study, we evaluated 105 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD), 121 patients with hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia as a control group. There was no difference for sex, mean age, and marital status among the groups, except that patients with IBD were younger than others (p family was as follows: 18 % in IBD, 9 % in dyspepsia, 28 % in hepatitis C with hepatic steatosis, 21.5 % in hepatitis C without steatosis, and 27 % in NAFLD (p = 0.006). Then, we divided the study group into two groups-group 1: IBD + dyspepsia + hepatitis C without hepatic steatosis, and group 2: hepatitis C with hepatic steatosis + NAFLD-and performed the same analysis. We found that the frequency of cancer in family was 16 % in group 1 (the patients without fatty liver) vs. 24.4 % in group 2 (those with fatty liver; p = 0.037). We also investigated the rate of operation in patients. The results were as follows: 33 % in group 1 vs. 43 % in group 2 (p = 0.043). Independently of the underlying chronic diseases, occurrence of fat in the liver increased the frequency of operation in patients with fatty liver and the rate of cancer in their first-degree relatives. Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operation in patients with fatty liver.

  20. Co-morbidities of Interstitial Cystitis

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    Gisela eChelimsky

    2012-08-01

    Full Text Available Introduction: This study aimed to estimate the proportion of patients with Interstitial Cystitis/Painful Bladder Syndrome (IC/BPS with systemic dysfunction associated co-morbidities such as irritable bowel syndrome (IBS and fibromyalgia (FM. Material and Methods: Two groups of subjects with IC/BPS were included: 1 Physician diagnosed patients with IC/BPS and 2 Subjects meeting NIDDK IC/PBS criteria based on a questionnaire (ODYSA. These groups were compared to healthy controls matched for age and socio-economic status. NIDDK criteria required: pain with bladder filling that improves with emptying, urinary urgency due to discomfort or pain, polyuria > 11 times/24 hrs, and nocturia > 2 times/night. The ODYSA instrument evaluates symptoms pertaining to a range of disorders including chronic fatigue, orthostatic intolerance, syncope, IBS, dyspepsia, cyclic vomiting syndrome, headaches and migraines, sleep, Raynaud’s syndrome and chronic aches and pains. Results: IC/BPS was diagnosed in 26 subjects (mean age 47 +/- 16 yrs, 92% females, 58 had symptoms of IC/BPS by NIDDK criteria, (mean age 40 +/- 17 yrs, 79% females and 48 were healthy controls (mean age 31+/- 14 yrs, mean age 77%. Co-morbid complaints in the IC/BPS groups included gastrointestinal symptoms suggestive of IBS and dyspepsia, sleep abnormalities with delayed onset of sleep, feeling poorly refreshed in the morning, waking up before needed, snoring, severe chronic fatigue and chronic generalized pain, migraines and syncope. Discussion: Patients with IC/BPS had co-morbid central and autonomic nervous system disorders. Our findings mirror those of others in regard to IBS, symptoms suggestive of FM, chronic pain and migraine. High rates of syncope and functional dyspepsia found in the IC/BPS groups merit further study to determine if IC/BPS is part of a diffuse disorder of central, autonomic and sensory processing affecting multiple organs outside the bladder.

  1. Functional disorders of the stomach

    Science.gov (United States)

    Koch, K. L.; Stern, R. M.

    1990-01-01

    Gastroenterologists frequently encounter patients who report vague epigastric discomforts or sensations of fullness, bloating, and distention in the upper abdomen. The discomfort is neither burning in character nor severe in intensity; there is no nocturnal pain. The epigastric location of discomfort and lack of radiation may help to exclude biliary tract and pancreatic diseases. Nausea may be present, but there is little or no vomiting. After these patients ingest liquids or solid foods, the symptoms of easy filling or early satiety and increasing discomfort and nausea are almost always present. The patient may only report "indigestion," but a specific chief complaint, such as pain, discomfort, nausea, or bloating may be elicited with further inquiries. Solid foods usually provoke more symptoms than do liquids. Symptoms of early satiety, nausea, bloating, and abdominal discomfort may culminate in the vomiting of undigested food. These vague upper gastrointestinal (GI) symptoms have been termed "dyspepsia." When peptic diseases of the stomach are excluded, the symptom complex has been called "nonulcer" dyspepsia, a vague syndrome with symptoms attributed to stomach dysfunction. Nonulcer dyspepsia has been reviewed recently. Such symptoms, commonly attributed to a "functional" disorder, are very common in clinical practice, with an incidence of 30% of patients. In this review, we will discuss an approach to the evaluation and treatment of patients with symptoms of nausea, early satiety, bloating, and vague epigastric discomfort--dyspeptic symptoms associated with functional stomach disorders. We will review the anatomy and motility of the stomach and suggest potential neuromuscular malfunctions of the stomach that may result in epigastric symptoms. The potential role of stress and other brain-gut interactions, which may underlie these symptoms, will also be reviewed.

  2. 黛力新联合胃动力药治疗功能性消化不良的临床效果分析

    Institute of Scientific and Technical Information of China (English)

    胡卫疆

    2014-01-01

    Objective To observe the functional dyspepsia effect of Deanxit joint motility drug treatment.Methods 80 patients with functional dyspepsia were randomly divided into two groups (n=40), oral omeprazole patients in the control group and maleic acid Trimebutine treatment, observation group was given oral Deanxit treatment on the basis of , 8 weeks after effects were observed. Results After eight weeks the total efficiency of 92.5% in the observation group, the control group, the total efficiency of 85.0%, the difference was statistically significant (P0.05).Conclusion The routine medicine treatment pulsing antidepressants has more satisfactory efficacy in functional dyspepsia.%目的:观察黛力新联合胃动力药治疗功能性消化不良的疗效。方法将80例功能性消化不良患者随机分为两组,每组40例,对照组患者口服奥美拉和马来酸曲美布汀治疗,观察组在此基础上给予口服黛力新治疗,8周后观察疗效。结果治疗8周后观察组总有效率92.5%,对照组总有效率85.0%,两组比较差异有统计学意义(P0.05)。结论黛力新联合奥美拉唑、马来酸曲美布汀治疗功能性消化不良疗效显著,不良反应相对轻微。

  3. Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature.

    Science.gov (United States)

    Sahin, Suleyman; Karatas, Fatih; Hacioglu, B; Aytekin, A; Imamoglu, I; Koseoglu, N; Sari, E; Altinbas, M

    2015-01-01

    Krukenberg tumor (KT), mostly originates from gastric cancer, is the metastatic tumor of ovaries accounting for 1-2% of all ovarian cancer. Common presenting symptoms include abdominal pain, distension, and ascites. Rests of the patients have non-specific gastrointestinal symptoms including dyspepsia, weight loss, nausea and vomiting. Gynecologic symptoms such as virilization, menstrual bleeding or irregularity and amenorrhea are much less frequent in the literature cases. Here, we present an unusual case of KT presented with amenorrhea as the sole initial symptom.

  4. Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil

    Institute of Scientific and Technical Information of China (English)

    Mnica; Baraúna; Assumpo; Luisa; Caricio; Martins; Hivana; Patricia; Melo; Barbosa; Katarine; Antonia; dos; Santos; Barile; Sintia; Silva; de; Almeida; Paulo; Pimentel; Assumpo; Tereza; Cristina; de; Oliveira; Corvelo

    2010-01-01

    AIM: To establish whether virulence factor genes vacA and cagA are present in Helicobacter pylori (H. pylori) retrieved from gastric mucosa and dental plaque in pa-tients with dyspepsia. METHODS: Cumulative dental plaque specimens and gastric biopsies were submitted to histological exami-nation, rapid urease test and polymerase chain reac-tion (PCR) assays to detect the presence of cagA and vacA polymorphisms.RESULTS: Detection of H. pylori from dental plaque and gastric biopsy samples was greater by PCR co...

  5. Neutron activation analysis of chemical impurities in manipulated samples of omeprazole

    Energy Technology Data Exchange (ETDEWEB)

    Sepe, Fernanda Peixoto; Leal, Alexandre Soares; Gomes, Tatiana Cristina Bomfim; Menezes, Maria Angela de Barros Correia; Silva, Maria Aparecida, E-mail: asleal@cdtn.br [Nuclear Technology Development Centre/Brazilian Commission for Nuclear Energy (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    In this work, samples of Omeprazole (C{sub 17}H{sub 19}N{sub 3}O{sub 3}S), a largely used drug in the treatment of dyspepsia and peptic ulcer, were acquired from five different pharmacies of manipulation - or retail pharmacies which prepare personalized drugs under medical recommendation - in Belo Horizonte/Brazil and investigated using the k{sub 0} - Neutron Activation Analysis (NAA). The preliminary results showed the presence of elements not foreseen in the original formula. It confirms the potential risk offered by medicines without suitable inspection. (author)

  6. Helicobacter pylori

    DEFF Research Database (Denmark)

    Leth, Peter Mygind

    1992-01-01

    Helicobacter pylori (HP) are Gram-negative spiral bacteria which occur in the human stomach. The bacteria were cultured in vitro for the first time in 1983. It is suspected that the bacteria may cause chronic gastritis of type B and may also be a contributory cause of chronic ulceration and cancer...... of the stomach. The bacteria are accompanied by characteristic inflammatory changes in the gastric mucosa. The significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcinoma of the stomach is discussed. HP occurs in a great proportion of the population of the world and the frequency increases...

  7. Clinical and radiologic review of uncommon cause of profound iron deficiency anemia: Median arcuate ligament syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Gunduz, Yasemin; Asil, Kiyasrttin; Aksoy, Yakup Ersel; Ayhan, Lacin Tatli [Dept. of Radiology, Sakarya University Medical Faculty, Sakarya (Turkmenistan)

    2014-08-15

    Median arcuate ligament syndrome is an anatomic and clinical entity characterized by dynamic compression of the proximal celiac artery by the median arcuate ligament, which leads to postprandial epigastric pain, vomiting, and weight loss. These symptoms are usually nonspecific and are easily misdiagnosed as functional dyspepsia, peptic ulcer disease, or gastropathy. In this report, we presented a 72-year-old male patient with celiac artery compression syndrome causing recurrent abdominal pain associated with gastric ulcer and iron deficiency anemia. This association is relatively uncommon and therefore not well determined. In addition, we reported the CT angiography findings and three-dimensional reconstructions of this rare case.

  8. Dual specimens increase the diagnostic accuracy and reduce the reaction duration of rapid urease test

    Institute of Scientific and Technical Information of China (English)

    Wen-Hung; Hsu; Sophie; SW; Wang; Chiao-Yun; Chen; Ching-Wen; Chang; Jaw-Yuan; Wang; Yuan-Chieh; Yang; Deng-Chyang; Wu; Ming-Tsang; Wu

    2010-01-01

    AIM:To evaluate the influence of multiple samplings during esophagogastr oduodenoscopy(EGD) on the accuracy of the rapid urease test,and the validity of newly developed rapid urease tests,HelicotecUT plus test and HelicotecUT test,CLO test and ProntoDry test.METHODS:A total of 355 patients undergoing EGD for dyspepsia were included.Their Helicobacter pylori(H.pylori) treatment status was either nave or eradicated.Six biopsy specimens from antrum and gastric body,respectively,were obtained during EGD.Single...

  9. Benign duodenocolic fistula as a complication of peptic ulcer disease.

    Science.gov (United States)

    Kamani, Fereshteh; Hessami, Reza; Abrishami, Alireza

    2014-01-01

    A 44-year-old man with upper abdominal pain, diarrhea and 25 kg weight loss since 3 months ago was admitted. He had a history of dyspepsia and peptic ulcer disease 4 months before admission. Gastroduodenal endoscopy and upper gastrointestinal series with barium study were done. Biopsies and CT-scan ruled out malignancies. Endoscopy and radiology studies revealed a duodenocolic fistula. He underwent right hemicolectomy, fistula en bloc excision, and distal gastrectomy surgery with gastrojejunostomy and ileocolic anastomosis. Radiologic modalities are necessary before surgery. Surgery is the only curative treatment in benign cases and reconstruction method is dependent on patient's situation.

  10. Constipation in adults with neurofibromatosis type 1