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Sample records for dysmenorrhea

  1. Dysmenorrhea.

    Science.gov (United States)

    French, Linda

    2005-01-15

    Dysmenorrhea is the leading cause of recurrent short-term school absence in adolescent girls and a common problem in women of reproductive age. Risk factors for dysmenorrhea include nulliparity, heavy menstrual flow, smoking, and depression. Empiric therapy can be initiated based on a typical history of painful menses and a negative physical examination. Nonsteroidal anti-inflammatory drugs are the initial therapy of choice in patients with presumptive primary dysmenorrhea. Oral contraceptives and depo-medroxyprogesterone acetate also may be considered. If pain relief is insufficient, prolonged-cycle oral contraceptives or intravaginal use of oral contraceptive pills can be considered. In women who do not desire hormonal contraception, there is some evidence of benefit with the use of topical heat; the Japanese herbal remedy toki-shakuyaku-san; thiamine, vitamin E, and fish oil supplements; a low-fat vegetarian diet; and acupressure. If dysmenorrhea remains uncontrolled with any of these approaches, pelvic ultrasonography should be performed and referral for laparoscopy should be considered to rule out secondary causes of dysmenorrhea. In patients with severe refractory primary dysmenorrhea, additional safe alternatives for women who want to conceive include transcutaneous electric nerve stimulation, acupuncture, nifedipine, and terbutaline. Otherwise, the use of danazol or leuprolide may be considered and, rarely, hysterectomy. The effectiveness of surgical interruption of the pelvic nerve pathways has not been established.

  2. Dysmenorrhea: Painful Periods

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    ... relieved. Pain relievers or hormonal medications, such as birth control pills, often are prescribed. Some lifestyle changes also may ... to endometriosis as the cause of your dysmenorrhea, birth control pills, the birth control implant, the injection, or the ...

  3. Imaging of membranous dysmenorrhea

    Energy Technology Data Exchange (ETDEWEB)

    Rouanet, J.P.; Daclin, P.Y.; Turpin, F.; Karam, R.; Prayssac-Salanon, A. [Dept. of Radiology, C. M. C. Beausoleil, Montpellier (France); Courtieu, C.R. [Dept. of Gynecology, C. M. C. Beausoleil, Montpellier (France); Maubon, A.J. [Dept. of Radiology, C. M. C. Beausoleil, Montpellier (France); Dept. of Radiology, C. H. U. Dupuytren, Limoges (France)

    2001-06-01

    Membranous dysmenorrhea is an unusual clinical entity. It is characterized by the expulsion of huge fragments of endometrium during the menses, favored by hormonal abnormality or drug intake. This report describes a case with clinical, US, and MRI findings before the expulsion. Differential diagnoses are discussed. (orig.)

  4. A case of unilateral dysmenorrhea

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    Tulon Borah

    2010-01-01

    Full Text Available Unilateral dysmenorrhea in an adolescent may be associated with uterine malformation. Relevant investigations in suspected cases and timely intervention can prevent future complications in such cases. Here, we present a case of unicornuate uterus with rudimentary horn in an adolescent complaining of unilateral dysmenorrhea.

  5. Guaifenesin as a treatment for primary dysmenorrhea.

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    Marsden, Jennifer S; Strickland, Charlene D; Clements, Tina L

    2004-01-01

    Dysmenorrhea is highly prevalent and causes much work loss and discomfort. A treatment with a new mechanism of action could benefit women of menstruating age. A study was undertaken to assess the efficacy of guaifenesin as a treatment for primary dysmenorrhea because of its effects of cervical dilation and cervical mucous thinning. Thirty-four subjects with primary dysmenorrhea were enrolled in a double-blind, placebo-controlled study. Three treatment surveys measured 10 symptoms (lower abdominal pain, general abdominal pain, back pain, headache, nausea, diarrhea, constipation, menstrual flow, weakness, and activities of daily living) on a 100-mm visual analog scale. Nonstudy analgesic use was also measured. Twenty-five subjects returned the first treatment survey, and 17 returned all 3 surveys. Results were nonsignificant, but guaifenesin trended toward being better than placebo for dysmenorrhea pain and associated constitutional symptoms and caused no worsening of symptoms. Lower abdominal mean pain scores from the first survey decreased 38 mm for guaifenesin versus 7 mm for placebo. By the third survey, only 2 of 8 guaifenesin participants took nonstudy analgesics compared with all 9 placebo subjects. Guaifenesin may be useful in the treatment of primary dysmenorrhea. A larger study is needed to validate these initial findings.

  6. Evaluating dysmenorrhea in a sample of Turkish nursing students.

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    Seven, Memnun; Güvenç, Gülten; Akyüz, Aygül; Eski, Fatma

    2014-09-01

    The aim of this study was to determine the prevalence and symptoms of dysmenorrhea, its relevant factors, and the rate of seeking medical help in a group of nursing students. A total of 380 students were included in the study. The demographic data questionnaire, a Daily Menstrual Symptom Rating Scale (DMSR), and the Visual Analog Scale for pain (VASP) were used as tools for data collection. The mean age of the participants was 20.31 ± 1.10 years. Most students had experienced dysmenorrhea (84.9%). Menstrual pain was frequently initiated on the first day of menstruation (77.8%). The most commonly reported menstrual problems were irregular menstrual cycles (27.2%) and oligomenorrhea (15.1%). Only 24.1% of students consulted their physicians for dysmenorrhea. The participants who had dysmenorrhea had significantly higher symptom scores than the participants who had not had dysmenorrhea, in terms of decreased activities, tension, hip and abdominal pain, backache, headache, and fatigue. Also, having a sister with dysmenorrhea increased the risk of dysmenorrhea. Although dysmenorrhea is a gynecological problem that is commonly seen in young women and that negatively affects daily activities and school life, the rate of seeking medical help is low. Adolescents should, therefore, be educated and counseled to determine the underlying cause and to increase the use of an effective treatment method. Considering that nurses should be better informed about dysmenorrhea causes and treatment options, a study of nursing students was undertaken.

  7. Valdecoxib for Treatment of Primary Dysmenorrhea

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    Daniels, Stephen E; Torri, Sarah; Desjardins, Paul J

    2005-01-01

    OBJECTIVE To compare the analgesic efficacy of valdecoxib with placebo and naproxen sodium for relieving menstrual cramping and pain due to primary dysmenorrhea. DESIGN Single-center, double-blind study with a 4-period, 4-sequence crossover design. Patients assessed pain intensity and pain relief at regular intervals up to 12 hours following the initial dose. SETTING Privately owned outpatient clinic. PATIENTS/PARTICIPANTS One hundred twenty patients with moderate to severe menstrual cramping were randomized. Eighty-seven patients completed all treatment cycles. INTERVENTIONS Valdecoxib 20 mg or 40 mg, naproxen sodium 550 mg, or placebo twice a day as required for ≤3 days in a single menstrual cycle. MEASUREMENTS AND MAIN RESULTS Both doses of valdecoxib (20 and 40 mg) were comparable to naproxen sodium and superior to placebo at all time points assessed for each of the primary end points. Valdecoxib and naproxen sodium had comparable onset and duration of action. Although the study design allowed patients 2 doses per day, only 15% and 20% of patients in the valdecoxib 20 mg and valdecoxib 40 mg groups, respectively, required remedication within the first 12 hours. The incidence of adverse events was similar between active and placebo groups. CONCLUSION Valdecoxib provided a fast onset of analgesic action, a level of efficacy similar to naproxen sodium, and a high level of patient satisfaction in the relief of menstrual pain due to primary dysmenorrhea. Valdecoxib was effective and well tolerated and thus appears to be a viable treatment for menstrual pain due to primary dysmenorrhea. PMID:15693930

  8. Effect of aromatherapy massage on dysmenorrhea in Turkish students.

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    Apay, Serap Ejder; Arslan, Sevban; Akpinar, Reva Balci; Celebioglu, Ayda

    2012-12-01

    The purpose of this study was to investigate the effect of aromatherapy massage on dysmenorrhea. The study used a quasiexperimental design with the subjects as their own control. Every participant applied both aromatherapy massage with lavender oil and placebo massage with odorless liquid petrolatum [soft paraffin]. The population comprised 438 midwifery and nursing students. The 150 students who had declared that they had suffered from dysmenorrhea used a visual analog scale to indicate their level of pain. Higher scores reflected a greater severity of dysmenorrhea. Forty-four students volunteered to participate in the study. When the lavender massage and the placebo massage were compared, the visual analog scale score of the lavender massage was found to decrease at a statistically significant rate. This study showed that massage was effective in reducing dysmenorrhea. In addition, this study showed that the effect of aromatherapy massage on pain was higher than that of placebo massage.

  9. Endometriosis, dysmenorrhea and diet--what is the evidence?

    DEFF Research Database (Denmark)

    Fjerbaek, Agnete; Knudsen, Ulla Breth

    2007-01-01

    polyunsaturated fat, ham, beef and other red meat. Results concerning fish intake were not consistent. Eight trials of different design, with a total of 1097 women, investigated the relationship between diet and dysmenorrhea. Intake of fish oil seemed to have a positive effect on pain symptoms. This study...... concludes that literature on diet and endometriosis is sparse, whereas eight studies have looked at diet and dysmenorrhea. No clear recommendations on what diet to eat or refrain from to reduce the symptoms of endometriosis can be given, while a few studies indicate that fish oil can reduce dysmenorrhea...... polyunsaturated fat, ham, beef and other red meat. Results concerning fish intake were not consistent. Eight trials of different design, with a total of 1097 women, investigated the relationship between diet and dysmenorrhea. Intake of fish oil seemed to have a positive effect on pain symptoms. This study...

  10. The effect of aromatherapy with rose oil on primary dysmenorrhea

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    Saadat

    2014-01-01

    Introduction: Primary dysmenorrhea (PD) is the most common gynecologic complaint. This complaint can cause problems such as lower quality of life, and sickness absenteeism from both classes and work. This study aimed to evaluate the effect of aromatherapy with rose oil massage on primary dysmenorrhea. Methods: This study is a randomized controlled trial. Subjects were 75 students from Tehran University of Medical Sciences. Three dormitories were selected randomly among dormi...

  11. Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.

    Science.gov (United States)

    Ortiz, Mario I

    2010-09-01

    To evaluate the prevalence, impact and treatment of primary dysmenorrhea among Mexican university students. A multiple-choice questionnaire was administered to 1539 students in six university programs: medicine, nursing, nutrition, dentistry, pharmacy and psychology. Data on the presence, severity, symptoms, treatment and limitations caused by dysmenorrhea were obtained and analyzed. The mean+/-SD age of the women was 20.4+/-2.0 years; the mean age of menarche was 12.3+/-1.5 years. A total of 64% of the women experienced dysmenorrhea. Dysmenorrhea was more prevalent among nutrition and psychology students than among medicine, pharmacy and dentistry students (pstudents showed an intensity of pain that was significantly higher than that of medicine and dentistry students (pabsenteeism (SA) as a result. Of those who experienced dysmenorrhea, 25.9% consulted a physician, and 61.7% practiced self-medication (SM). The most common medications used were an over-the-counter (OTC) medication with paracetamol (an analgesic), pamabrom (a diuretic), and pyrilamine (a histamine antagonist), another OTC with metamizol (a non-steroidal anti-inflammatory drug [NSAID]) plus butylhioscine (an antispasmodic drug) and naproxen (a NSAID). Of those women using prescribed medications, 18.4% reported complete remission of their symptoms, while 78.1% reported little to moderate alleviation, and 3.6% reported no effect on their menstrual distress. Similarly, of the women who practiced SM, 23.4% reported complete relief, 75.5% reported little to moderate effectiveness, and 1.0% reported no efficacy. The prevalence of dysmenorrhea among Mexican university students is high, and the pain that these women suffer can be severe, disabling and result in short-term SA. The pain is often not completely relieved despite the use of medication. It is necessary to improve the therapeutic options for relief of pain caused by dysmenorrhea and to minimize the impact of dysmenorrhea on social, economic and

  12. Management of Primary Dysmenorrhea by School Adolescents in ILE-IFE, Nigeria

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    Ogunfowokan, Adesola A.; Babatunde, Oluwayemisi A.

    2010-01-01

    Dysmenorrhea is a problem that girls and women face and often manage themselves with or without support from health professionals. A cross-sectional, descriptive study was conducted among adolescents with dysmenorrhea (N = 150) in Ile-Ife, Nigeria. The aims of the study were to determine their knowledge of menstruation and primary dysmenorrhea,…

  13. ACUPUNCTURE FOR PRIMARY DYSMENORRHEA-A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    CHOU Chin-shan; LIU Bao-yan; ZHANG Lu; JIN Zhi-gao

    2005-01-01

    Recent literature search showed that up to now there are a total of 9 theses about clinical treatment of primary dysmenorrhea with acupuncture therapy, among them 5 clinical trials are from Chinese journals and the rest 4 from foreign journals. Majority of the trials have some methodological and/or reporting shortcomings. The frequency and intensity of dysmenorrhea are divided into intermittent and continuous types. Results of quantitative meta-analysis with Revman 4.1 software showed that the existing evidence supports the value of acupuncture for the treatment of dysmenorrhea. However, the quality of evidence is not fully convincing. There is an urgent need for well-planned, large-scale and multiple-center studies to assess the effectiveness and cost-effectiveness of acupuncture under real-life conditions.

  14. Prevalence of dysmenorrhea and its correlating lifestyle factors in Japanese female junior high school students.

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    Kazama, Mie; Maruyama, Keiko; Nakamura, Kazutoshi

    2015-01-01

    Dysmenorrhea is a common menstrual disorder experienced by adolescents, and its major symptoms, including pain, adversely affect daily life and school performance. However, little epidemiologic evidence on dysmenorrhea in Japanese adolescents exists. This cross-sectional study aimed to determine the prevalence of and identify factors associated with dysmenorrhea in Japanese female junior high school students. Among 1,167 girls aged between 12 and 15 years, 1,018 participants completed a questionnaire that solicited information on age at menarche, menstruation, and lifestyle, as well as demographic characteristics. Dysmenorrhea was defined based on menstrual pain using a Visual Analog Scale (VAS), with moderate or severe (moderate-severe) dysmenorrhea, which adversely affects daily life, defined as VAS ≥ 4, and severe dysmenorrhea defined as VAS ≥ 7. The prevalence of moderate-severe dysmenorrhea was 476/1,018 (46.8%), and that of severe dysmenorrhea was 180/1,018 (17.7%). Higher chronological and gynecological ages (years after menarche) were significantly associated with a higher prevalence of dysmenorrhea regardless of severity (P for trend students. Health education teachers should be made aware of these facts, and appropriately care for those suffering from dysmenorrhea symptoms, absentees, and those experiencing difficulties in school life due to dysmenorrhea symptoms.

  15. Dysmenorrhea in a multiethnic population of adolescent Asian girls.

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    Wong, Li Ping; Khoo, Ee Ming

    2010-02-01

    To determine the prevalence of dysmenorrhea, its impact, and the treatment-seeking behavior of adolescent Asian girls. A cross-sectional study with 1092 girls from 15 public secondary schools and 3 ethnic groups in the Federal Territory of Kuala Lumpur, Malaysia. Overall, 74.5% of the girls who had reached menarche had dysmenorrhea; 51.7% of these girls reported that it affected their concentration in class; 50.2% that it restricted their social activities; 21.5% that it caused them to miss school; and 12.0% that it caused poor school performance. Ethnicity and form at school were significantly associated with the poor concentration, absenteeism, and restriction of social and recreational activities attributed to dysmenorrhea. Only 12.0% had consulted a physician, and 53.3% did nothing about their conditions. There were ethnic differences in the prevalence, impact, and management of dysmenorrhea. There is a need for culture-specific education regarding menstruation-related conditions in the school curriculum. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

  16. Treatment of Dysmenorrhea by Acupuncture plus Auricular Acupuncture

    Institute of Scientific and Technical Information of China (English)

    CAI Zhi-jun; LI Fang; LU Mei; XIAO Yuan-chun

    2004-01-01

    采用针刺和电耳针相结合的方法治疗气滞血瘀型痛经38例,取得良好疗效,有效率达974%.%The authors adopted acupuncture plus auricular electro-acupuncture to treat 38 cases of dysmenorrhea belonging to qi stagnation and blood stasis pattern, the better therapeutic effect was achieved, with the effective rate of 97.4%.

  17. Acupuncture Treatment of Dysmenorrhea Resistant to Conventional Medical Treatment

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    V. Iorno

    2008-01-01

    Full Text Available We evaluated the effect of acupuncture on NSAID resistant dysmenorrhea related pain [measured according to Visual Analogue Scale (VAS] in 15 consecutive patients. Pain was measured at baseline (T1, mid treatment (T2, end of treatment (T3 and 3 (T4 and 6 months (T5 after the end of treatment. Substantial reduction of pain and NSAID assumption was observed in 13 of 15 patients (87%. Pain intensity was significantly reduced with respect to baseline (average VAS = 8.5, by 64, 72, 60 or 53% at T2, T3, T4 or T5. Greater reduction of pain was observed for primary as compared with secondary dysmenorrhea. Average pain duration at baseline (2.6 days was significantly reduced by 62, 69, 54 or 54% at T2, T3, T4 or T5. Average NSAID use was significantly reduced by 63, 74, 58 or 58% at T2, T3, T4 or T5, respectively, and ceased totally in 7 patients, still asymptomatic 6 months after treatment. Our findings suggest that acupuncture may be indicated to treat dysmenorrhea related pain, in particular in those subjects in whom NSAID or oral contraceptives are contraindicated or refused.

  18. The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea

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    Batool Teimoori

    2016-03-01

    Full Text Available Objectives: Dysmenorrhea is a common complaint in women. Primary dysmenorrhea is defined as painful menstruation in the absence of pelvic disease and is caused by uterine contractions caused by prostaglandins released from the endometrium. Conventional treatments include nonsteroidal anti-inflammatory drugs and oral contraceptives. We sought to evaluate the efficacy of zinc supplementation in the treatment of primary dysmenorrhea.  Methods: Two-hundred participants with primary dysmenorrhea were randomized into one of two groups. The intervention group received zinc and mefenamic acid, and the control group received mefenamic acid and a placebo drug. After three months of treatment, changes in the incidence of dysmenorrhea and the degree of pain were measured in both groups.  Results: The mean pain score before administration of zinc and mefenamic acid in the intervention group was 5.3±1.8 and after treatment was 1.2±1.9 (p 0.050. We also found that 64% of case group and 33% of the control group did not experience dysmenorrhea after treatment (p < 0.001.  Conclusions: The use of a zinc supplement in combination with mefenamic acid was superior in reducing primary dysmenorrhea compared to mefenamic acid alone.

  19. [Evaluating the relation of premenstrual syndrome and primary dysmenorrhea in women diagnosed with fibromyalgia].

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    Terzi, Rabia; Terzi, Hasan; Kale, Ahmet

    2015-01-01

    In this study, we aimed to investigate the presence of premenstrual syndrome (PMS), primary dysmenorrhea (PD) and depression among women with fibromyalgia (FM) and healthy females and to determine possible factors related with PMS and PD in FM. The present study was conducted on 98 female patients diagnosed with FM and 102 age and sex-matched healthy controls. All patients were evaluated for premenstrual syndrome (PMS) and primary dysmenorrhea (PD). Premenstrual syndrome was assessed among the patients for the presence of one or more affective or somatic symptoms within the five days preceding menses. The diagnosis of primary dysmenorrhea was defined as having abdominal pain or lower back pain lasting at least two days during a menstrual period. Dysmenorrhea was assessed via visual analog scale. Dysmenorrhea was rated via Multidimensional Scoring System. The Hamilton depression scale was applied to all patients. Primary dysmenorrhea was established in 41% of FM patients and 28% of the control group. A statistically significant difference was found in PD between the two groups (p=0.03). PMS was established in 42% of the FM patients and 25% of the control group. A statistically significant difference was found in PMS between the two groups (p=0.03). There is an increased frequency of premenstrual syndrome and dysmenorrhea in FM patients. The patients with high symptom severity scores and high depression scores among the FM patients are at risk of PMS and PD. Copyright © 2015 Elsevier Editora Ltda. All rights reserved.

  20. Familial Predisposition of Primary Dysmenorrhea among Senior High School Girl Students

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    Prema Sharlini

    2015-12-01

    Full Text Available Background: Dysmenorrhea is a common female reproductive problem in women of active reproductive age which is characterized by menstrual pain or cramps in a women’s lower abdomen or back. Dysmenorrhea can be classified into primary and secondary. One of the associated risk factor of primary dysmenorrhoeais the family history, however the study on the family history of primary dysmenorrhea with recurrent menstrual pain is limited. This study was conducted to identify the correlation between family history and primary dysmenorrhea in high school girls. Methods: This cross sectional study was conducted at several senior high schools in Jatinangor from April−June 2013. One hundred and sixty two students were included in this study. The sample size was calculated based on the unpaired−dichotomous variable for the two−sided formula. A self administered questionnaire was distributed to the senior high school girl students who were in their menarche age, menstrual cycle characteristics, presence or absence of dysmenorrhea, severity of pain and presence dysmenorrhea in mothers and in sisters were inquired. Data were analyzed using chi square test. Results: Overall, there were association between positive family history and primary dysmenorrhea among the students with (p<0.001. The prevalence of dysmenorrhea in the students was 92.6% with 95% confidence interval which was 87.5−95.7%. The prevalence rate was 67.9% in mothers with 95% confidence interval which is 60.4−74.6% and 80.2% prevalence of primary dysmenorrhoea in sisters with 95% confidence interval which is 73.4−85.6%. Conclusions: There is a significant association between positive family history and primary dysmenorrhea

  1. Women with dysmenorrhea are hypersensitive to experimental deep muscle pain across the menstrual cycle.

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    Iacovides, Stella; Baker, Fiona C; Avidon, Ingrid; Bentley, Alison

    2013-10-01

    Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to deep muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to deep muscle pain compared to women without dysmenorrhea. Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, deep muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation. Copyright © 2013 American Pain Society. Published by Elsevier Inc. All rights reserved.

  2. Inhibitory Effects of Far-Infrared Ray-Emitting Belts on Primary Dysmenorrhea

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    Ben-Yi Liau

    2012-01-01

    Full Text Available This study investigated the therapeutic effect of the far-infrared ray-emitting belt (FIRB in the management of primary dysmenorrhea in female patients. Forty adolescent females with primary dysmenorrhea were enrolled in the study. Quantitative measurements were taken during the menstruation. Several parameters were measured and compared, including temperature, abdominal blood flow, heart rate variability, and pain assessment. Statistical analysis shows that treatment with FIRB had significant efficiency in increasing regional surface temperature and abdominal blood flow, widening standard deviation of normal-to-normal RR intervals, and reducing VRS and NRS pain scores. The application of an FIRB appears to alleviate dysmenorrhea.

  3. Prevalence and Factors Affecting Dysmenorrhea in Female University Students: Effect on General Comfort Level.

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    Aktaş, Demet

    2015-08-01

    The purpose of this study was to investigate the prevalence and the affecting factors of dysmenorrhea and its effects on overall comfort among female university students. This was a cross-sectional study. The research was carried out between October and November 2013 at a university in Ankara. This study was conducted with 200 female students. The data were analyzed using frequencies, means, SD, χ(2) tests, independent t tests and analysis of variance. Data were collected using an interview questionnaire, the visual analog scale (VAS) and the General Comfort Questionnaire. The mean age of students in this study group was 20.85 ± 2.15 years. The prevalence of dysmenorrhea in the students was 84%. The mean severity of pain was 5.78 ± 2.45 on the VAS. The present study found that 45.8% of female students experienced moderate menstrual pain and the most common co-occurring symptoms were irritability (34.6%) and fatigue (21.5%). One-fourth of the students with dysmenorrhea consulted the advice of a physician and the most commonly used methods for pain were analgesics (69%), heat application (56.5%), and rest (71.4%). Family history of dysmenorrhea, education about menstruation, and frequency of menstrual cycle were identified as important factors in the development of dysmenorrhea (p students with dysmenorrhea (2.57 ± 0.25) was lower than that of students without the condition (2.65 ± 0.23). Also, use of the methods for management of dysmenorrhea was found to increase students' general comfort levels. Therefore, it is important for nurses to educate and advise adolescents and young women about dysmenorrhea.

  4. [Professor ZHAO Jiping's meridian diagnosis and treatment for primary dysmenorrhea].

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    Tan, Cheng; Zhang, Chang; Zhang, Jiajia; Wang, Jun

    2016-03-01

    For the treatment of primary dysmenorrhea, professor ZHAO Jiping focuses on meridian diagnosis and inspection, and uses pressing methods to locate the response points along the meridian, including acupoints and aishi points. During the stage of attack, it is essential to press along the spleen meridian, mainly Sanyinjiao (SP 6), Diji (SP 8) and Yinlingquan (SP 9); during the stage of remission, it is essential to press along the bladder meridian and stomach meridian, mainly Ganshu (BL 18), Pishu (BL 20), Weishu (BL 21), Shenshu (BL 23) and Zusanli (ST 36). The differences between deficiency syndrome and excess syndrome lead to the different feelings of doctors and patients. Combined with the results of meridian diagnosis and inspection, the aim of treatment can be achieved by different acupuncture methods. Professor ZHAO pays attention to the treatment of accompanied symptoms and timing of treatment, since the relief of accompanied syndromes and selection of timing are keys to relieving patient's pain.

  5. The effects of acupressure points in SP6 and SP8 on primary dysmenorrhea

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    Alireza Akbarzade

    2011-09-01

    Full Text Available Background: Dysmenorrhea is one of the most common disorders of women in reproductive age. In addition to physical and psychological disturbances, it may cause socioeconomic problems. The acupressure is a suggested treatments for dysmenorrhea. This study was conducted to identify and compare the effects of acupressure in Saninjo and DiJi points on pain severity of primary dysmenorrhea and systematic symptoms associated with it. Methods: This study was a cross-over clinical trial. 50 girls aged between 18 and 30 years old referred to an urban health center in Sar-e-Pol-e-Zahab city were selected. Subjects randomly allocated into two equal groups (A and B and were assessed over three consecutive menstrual cycles. A questionnaire was used for data collection. Validity and reliability determined by content validity and test retest methods respectively. Pain severity was assessed using McGill pain ruler. At the end, data from 42 women were used for analysis with SPSS package.Results: The severity of primary dysmenorrhea was 6.65±1.05 in SP6 and 6.84 ±1.9 in SP8 before acupressure and significantly decreased to 2.89±1.36 and 2.03±0.94 respectively after acupressure (P<0.001. Conclusion: We can conclude that dysmenorrhea pain decreased after acupressure and SP6 and SP8 points can be used as an urgent remedy to alleviate primary dysmenorrhea.

  6. The influence of intrauterine contraception on the prevalence and severity of dysmenorrhea: a longitudinal population study.

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    Lindh, Ingela; Milsom, Ian

    2013-07-01

    Does intrauterine contraception influence the prevalence and severity of dysmenorrhea? In this longitudinal study, a copper intrauterine device (Cu-IUD) did not influence the severity of dysmenorrhea, whereas the levonorgestrel-releasing intrauterine system (LNG-IUS) reduced dysmenorrhea severity. Dysmenorrhea is a common problem among young women. The LNG-IUS has been reported to be associated with less painful menstruation, although more long-term studies are necessary. In contrast Cu-IUDs have been reported to exacerbate dysmenorrhea. A longitudinal population study. The prevalence and severity of dysmenorrhea was compared in a longitudinal analysis of variance performed in the same women when using either intrauterine contraception (Cu-IUD or LNG-IUS) or combined oral contraceptives (COCs) with other methods of contraception or no contraception. Random samples of 19-year-old women born in 1962 (n = 656), 1972 (n = 780) and 1982 (n = 666) assessed at 5-year intervals between 1981 and 2001. Current severity of dysmenorrhea was assessed on each occasion by a verbal multidimensional scoring system (VMS) and by a visual analog scale (VAS). Dysmenorrhea severity was unchanged in the same woman when using a Cu-IUD compared with using other methods (= condom use, barrier methods, natural family planning, coitus interruptus and sterilization)/no method of contraception in the longitudinal analysis of factors influencing dysmenorrhea severity (VMS score: +0.05 units/VAS: -0.3 mm, both NS). LNG-IUS and COC use were associated with reduced dysmenorrhea severity compared with other methods/no method (LNG-IUS use, VMS score: -0.4 units/VAS: -13 mm, both P VMS score: -0.4 units/VAS: -11 mm, both P VMS score: -0.3 units, P < 0.05/VAS: -16 mm, P < 0.001). Dysmenorrhea severity decreased between the ages of 19 and 44 years. There was a decline in the response rate over time during the 20 years of this longitudinal study which may be due to the fact that the distribution of

  7. Natural History of Irritable Bowel Syndrome in Women and Dysmenorrhea: A 10-Year Follow-Up Study

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    Linda Bjork Olafsdottir

    2012-01-01

    Full Text Available Background. Studies have shown that women are more likely to have irritable bowel syndrome (IBS and more women seek healthcare because of IBS than men. Aim. We wanted to examine the natural history of IBS and dysmenorrhea in women over a 10-year period and to assess the change in IBS after menopause. Method. A population-based postal study. A questionnaire was mailed to the same age- and gender-stratified random sample of the Icelandic population aged 18–75 in 1996 and again in 2006. Results. 77% premenopausal women had dysmenorrhea in the year 1996 and 74% in 2006. 42% of women with dysmenorrhea had IBS according to Manning criteria in the year 2006 and 49% in 1996. 26% of women with dysmenorrhea had IBS according to Rome III 2006 and 11% in the year 1996. In 2006 30% women had severe or very severe dysmenorrhea pain severity. More women (27% reported severe abdominal pain after menopause than before menopause 11%. Women without dysmenorrhea were twice more likely to remain asymptomatic than the women with dysmenorrhea. Women with dysmenorrhea were more likely to have stable symptoms and were twice more likely to have increased symptoms. Conclusion. Women with IBS are more likely to experience dysmenorrhea than women without IBS which seems to be a part of the symptomatology in most women with IBS. IBS symptom severity seems to increase after menopause.

  8. Experience of dysmenorrhea among a group of physical therapy students from Cairo University: an exploratory study

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    Kamel DM

    2017-05-01

    Full Text Available Dalia M Kamel,1,2 Sayed A Tantawy,2,3 Gehan A Abdelsamea1 1Department of Physical Therapy for Obstetrics & Gynecology, Faculty of Physical Therapy, Cairo University, Giza, Egypt; 2Physiotherapy Department, College of Medical and Health Sciences, Ahlia University, Manama, Kingdom of Bahrain; 3Department of Physiotherapy, Centre of Radiation, Oncology and Nuclear Medicine, Cairo University, Giza, Egypt Introduction: Dysmenorrhea is a condition describing the painful cramps that women feel before or during the menstrual period. While dysmenorrhea is the most common gynecologic complaint affecting adolescent and young women and there has been significant progress in understanding its pathophysiology and managing the symptoms, many young women do not seek medical consultation and remain untreated.Aim of the study: The aim of the study was to explore the prevalence of dysmenorrhea, its physical impact, and associated coping behaviors among university students.Methods: A total of 269 female college students volunteered to participate in the study. Data regarding the students’ experience with dysmenorrhea were collected via self-reported questionnaire developed based on relevant literature. Pain was scored on visual analog scale (VAS.Results: Most respondents (84.01% reported feeling pain in the abdomen and back (VAS score, 5.00. Mood swings (84.8% and dizziness (48.2% were, respectively, the most common affective and somatic symptoms related to menstruation. There was a significant difference in the amount of menstrual flow (p=0.004 and incidence of dysmenorrhea (p=0.03 according to menstrual regularity. Most students (91.2% did not seek medical consultation for dysmenorrhea, and 62.4% used analgesics. However, no significant correlation (p=0.25 was found between analgesic intake and pain relief. While most students (90.7% did not miss exams, 48.7% reported poor satisfaction with their academic performance because of dysmenorrhea

  9. Dysmenorrhea Characteristics of Female Students of Health School and Affecting Factors and Their Knowledge and Use of Complementary and Alternative Medicine Methods.

    Science.gov (United States)

    Midilli, Tulay Sagkal; Yasar, Eda; Baysal, Ebru

    2015-01-01

    The purpose of this study was to examine the menstruation and dysmenorrhea characteristics and the factors affecting dysmenorrhea of health school students, and the knowledge and use of the methods of complementary and alternative medicine (CAM) on the part of those students with dysmenorrhea. This is a descriptive study. A descriptive analysis was made by calculating the number, percentage, mean, Pearson χ, and logistic regression analysis. A total of 488 female students participated in the research and 87.7% (n = 428) of all students experienced dysmenorrhea. It was detected that a family history of dysmenorrhea and regular menstrual cycles of the students were dysmenorrhea-affecting factors (P students with dysmenorrhea used CAM methods. Heat application of CAM methods for dysmenorrhea management was the most commonly used and also known by the students. The students who experienced severe pain used analgesics (P < .05) and CAM methods (P < .05).

  10. A narrative review of medical, chiropractic, and alternative health practices in the treatment of primary dysmenorrhea.

    Science.gov (United States)

    Spears, Lolita G

    2005-01-01

    Primary dysmenorrhea and related issues are discussed as they influence the gynecological and social health of females during adolescence, adulthood, and senior maturity. Health practitioners are exposed to multiple approaches towards the management of menstrual pain. Clinical and social viewpoints target the causation, development, diagnosis, manifestation and management of primary dysmenorrhea. This narrative review includes the topic of the doctor-patient relationship in efforts of cultivating effectively communicative health practitioners. Controversial topics related to primary dysmenorrhea and the quality of life for women are addressed. A search for literature reviews, case studies, laboratory research, and clinical trials from 1985-2004 was performed using the MEDLINE database. Sources of additional information included textbooks, national organizational literature and contemporary articles. Menstrual pain is a prevalent experience yet it is socially taboo for conversation; as such, it poses a hindrance to its management. The communication between the doctor and patient is a critical barrier point between establishing a diagnosis and determining an appropriate treatment plan. A multi-disciple treatment plan varies as much as patients themselves vary in personal experiences, needs, and preferences. Medicinal prophylactics, physical therapeutics, non-acidic diets, herbal supplements, eastern therapies and the chiropractic manual adjustments of the spine are effective methods for the management of primary dysmenorrhea. The non-invasive management of primary dysmenorrhea includes the chiropractic adjustment with complimentary modalities, and other alternative health care practices. Medicinal prophylactics are invasive and pose a higher risk to long-term chemical exposure, side effects or irreversible conditions.

  11. Prevalence, Impact, and Management Practice of Dysmenorrhea among University of Gondar Students, Northwestern Ethiopia: A Cross-Sectional Study

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    Minaleshewa Biruk Gebeyehu

    2017-01-01

    Full Text Available Background. Dysmenorrhea is an important health problem of adolescents in school, as well as health practitioners, that badly affects the daily activities and quality of life. The aim of this study was to measure the prevalence of dysmenorrhea and assess its management practice among University of Gondar students. Methods. A cross-sectional study was done from April 06 to May 08, 2016, on female students of University of Gondar. Descriptive and binary logistic regression analyses were used to describe and assess the association between different variables. Results. More than two-thirds (75.3% of the respondents were nonmedical students and the prevalence of dysmenorrhea was 77.6%. About half (50.6% of the participants reported that they have a family history of dysmenorrhea and experienced continuous type of pain (53% which lasts 1-2 days (47.8%. Abdominal spasm (70.4%, back pain (69.7% fatigue, and weakness (63.5% were the most commonly experienced dysmenorrhea symptoms. More than half (63% of the respondents had encountered social withdrawal and decrease in academic performance (51.4%. More than two-thirds (63.8% of the respondents use home remedies as a primary management option. Ibuprofen and diclofenac were the most commonly used medications to manage dysmenorrhea. Conclusions. The present study revealed that high proportion of University of Gondar female students had dysmenorrhea. Findings suggest the need for educating adolescent girls on appropriate and effective management of dysmenorrhea.

  12. Effect of aromatherapy massage on pain in primary dysmenorrhea: A meta-analysis.

    Science.gov (United States)

    Sut, Necdet; Kahyaoglu-Sut, Hatice

    2017-05-01

    This meta-analysis investigates the effect of aromatherapy massage on pain in primary dysmenorrhea. Randomized controlled trials were searched by keywords in several databases (Pubmed, ISI Web of Sciences, and Google Scholar). Six randomized controlled trials that included 362 participants with primary dysmenorrhea, comparing abdominal aromatherapy massage (n = 184) with massage with placebo oils (n = 178), were analyzed in the meta-analysis. The change in the visual analogue scale (VAS) pain score from the first menstruation cycle to the second cycle at the first menstruation day was used as the primary outcome. Aromatherapy massage with essential oils was superior to massage with placebo oils (standardized mean difference = -1.06 [95% CI: -1.55 to -0.55]). Abdominal aromatherapy massage with essential oils is an effective complementary method to relieve pain in primary dysmenorrhea. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Patterns of prescription and self-medication for treating primary dysmenorrhea in a Mexican population.

    Science.gov (United States)

    Ortiz, Mario I; Fernández-Martínez, Eduardo; Pérez-Hernández, Nury; Macías, Arturo; Rangel-Flores, Eduardo; Ponce-Monter, Héctor

    2007-01-01

    Dysmenorrhea is defined as cramping pain in the lower abdomen occurring just before or during menstruation. Non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay of treatment, with the addition of oral contraceptive pills when necessary. With the widespread availability of over-the-counter NSAIDs, it is often assumed that women are treating themselves adequately. Unfortunately, this is not always the case. Therefore we evaluated the use of drugs for treating primary dysmenorrhea in Mexican students. A multiple-choice questionnaire was administered to 285 psychology students (20.6 +/- 2.4 yrs; range, 17-33 yrs), to assess the prevalence of dysmenorrhea and medications employed. The reported prevalence of dysmenorrhea among these women was 67%. Dysmenorrhea was mild in 34% moderate in 43% and severe in 21%. Of the dysmenorrheic sample, only 33.5% consulted physician in 2.6 +/- 0.2 cycles per year for their problem and the most common prescriptions were an over-the-counter medication with paracetamol pamabrom and pyrilamine maleate (Syncol; 22.4%) naproxen (18.4%), metamizole plus butylhyoscine bromide (10.2%), ibuprofen (6.1%) and butylhyoscine bromide (6.1%). On the other hand, self-medication was practiced by 64.9% of the women with dysmenorrhea in 6.1 +/- 3.8 cycles per year and the most common drugs by self-medication were Syncol (35.5%), naproxen (16.9%), metamizole plus naproxen butylhyoscine bromide (13.7%), an over-the-counter medication with adiphenine and propyphenazon (Espasmo-cibalgina; 10.5%), paracetamol (5.6%) butylhyoscine alone (4%) and ibuprofen (4%). Our data suggest that dysmenorrheic women use numerous drugs by self-medication for pain but infrequently accessed formal medical care.

  14. Effectiveness of vitamin E as treatment of primary dysmenorrhea in pubertal adolescents

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    Wagito

    2011-01-01

    Full Text Available Background Primary dysmenorrhea is a common complaint among adolescents. Absenteeism from work and school are associated with the severity of symptoms. Vitamin E is an alternative treatment for primary dysmenorrhea. Objective To evaluate the effectiveness of vitamin E as a treatment of primary dysmenorrhea. Methods We conducted a randomized, double-blind, controlled trial from August to October 2009. We included female adolescents with primary dysmenorrhea in this study. Subjects were divided into 2 groups by simple randomization. Each group received either 200 units of vitamin E or a placebo twice daily, beginning two days before menstruation and continuing until the third day of menstruation. Treatment was repeated for three menstrual cycles. Subjects recorded the severity and duration of pain in a daily diary. Data was analyzed using Chi-square, Mann-Whitney U-test, and independent t-test. Results One hundred-sixteen primary dysmenorrhea subjects enrolled in our study. By simple randomization, they were divided into two groups of 58 subjects each. There were no statistically significant differences between the two groups in the severity and duration of pain before the start of treatment and after 1 month of treatment. After treatment for 2 months and 3 months, there were statistically significant differences in pain severity (P=0.013, 95%CI -0.54 to -0.11; and P=0.0001, 95%CI -0.67 to -0.26, respectively and pain duration (P=0.025, 95%CI -0.65 to -0.07 and P=0.007, 95%CI -0.75 to -0.12, respectively between the 2 groups. Conclusion Vitamin E was effective in treatment of primary dysmenorrhea in pubertal adolescents after 2 and 3 months of treatment. [Paediatr Indones. 2011;51:41-6].

  15. [The relation between dysmenorrhea and hot flash in a group of women in climacteric].

    Science.gov (United States)

    Andreassi, S; Tesseri, E

    1992-01-01

    Hot flushes in climacteric age can cause noticeable discomfort to those who have them. This functional disturbance confirms the strong relationship between the gonadic steroids and the central neurotransmitters. These complex mechanisms which control reproductive functions limit our knowledge of the pathogenesis of hot flushes. The possible intervention of prostaglandins in the rising of this disturbance and their participation in dismenorrhea have raised the hypothesis that the prostaglandins may be the common denominator in the development of dysmenorrhea in fertile age women and of hot flushes in climacteric age women. Under this context, we examined a number of women in menopause to determine if they suffered with dysmenorrhea in fertile age.

  16. Acupuncture combined with spinal tui na for treatment of primary dysmenorrhea in 30 cases.

    Science.gov (United States)

    Guo, Aisong; Meng, Qingyi

    2008-03-01

    To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P < 0.05). Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.

  17. Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.

  18. Prevalence of dysmenorrhea and its effect on quality of life among a group of female university students.

    Science.gov (United States)

    Unsal, Alaettin; Ayranci, Unal; Tozun, Mustafa; Arslan, Gul; Calik, Elif

    2010-05-01

    The objective was to evaluate the prevalence of dysmenorrhea and determine its effect on health-related quality of life (HRQoL) among a group of female university students. This cross-sectional study was conducted between 15 March and 15 April 2009 at Dumlupinar University, Kutahya, Health High School, Western Turkey. The study group included 623 female students. The severity of dysmenorrhea was determined with a 10-point visual analog scale. The Short Form-36 (SF-36) form was used to determinate HRQoL. Chi-square test, Student's t test, and logistic regression and variance analyses (ANOVA) were used for statistical analyses. The average age of the study group was 20.8 +/- 1.8 years (range 17-30). Prevalence of dysmenorrhea was found to be 72.7% and was significantly higher in coffee consumers, females with menstrual bleeding duration > or =7 days, and those who had a positive family history of dysmenorrhea when compared to the others (P coffee consumption (OR 2.084), menstrual bleeding duration > or =7 days (OR 1.590), and positive family history of dysmenorrhea (OR 3.043) were important risk factors for dysmenorrhea. Except for social functioning, role-emotional, and mental health domains, the SF-36 points received from the other domains were higher in females with dysmenorrhea (for each one P students.

  19. Randomized controlled trial assessing a traditional Chinese medicine remedy in the treatment of primary dysmenorrhea

    NARCIS (Netherlands)

    Kennedy, S.; Jin, X.; Yu, H.; Zhong, S.; Magill, P.; Vliet, T. van; Kistemaker, C.; Voors, C.; Pasman, W.

    2006-01-01

    A proof-of-concept study to assess the safety and efficacy of a traditional Chinese medicine formula as treatment for primary dysmenorrhea showed no statistically significant benefit over placebo. However, some efficacy parameters suggested possible superiority of the active treatment and so a large

  20. Effects of Somatothermal Far-Infrared Ray on Primary Dysmenorrhea: A Pilot Study

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    Yu-Min Ke

    2012-01-01

    Full Text Available The purpose of this study was to assess the beneficial effects of using a far-infrared (FIR belt on the management of patients with primary dysmenorrhea. This is the first study to determine the efficacy of somatothermal FIR using a parallel-arm randomized sham-controlled and double-blinded design with objective physical evidence and psychometric self-reports. Fifty-one Taiwanese women with primary dysmenorrhea were enrolled in the study. Results indicate that there was an increased abdominal temperature of 0.6°C and a 3.27% increase in abdominal blood flow in the FIR group (wearing FIR belt compared to those in the control group (wearing sham belt. Verbal rating scale and numeric rating scale scores in the FIR group were both lower than those in the control group. Compared to the blank group (wearing no belt, the average dysmenorrhea pain duration of the FIR group was significantly reduced from 2.5 to 1.8 days, but there was no significant difference in the control group. These results demonstrate that the use of a belt made of far-infrared ceramic materials can reduce primary dysmenorrhea.

  1. Comparison ginger and resistance training on primary dysmenorrhea in female students of Shiraz university

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    Nafiseh Saadat nejad

    2015-04-01

    Full Text Available Background: Although some remedies have been suggested for treatment of primary dysmenorrhea, some free of side effects treatment methods such as herbal drugs and exercise are especially important .The purpose of this study was to compare the effect of ginger and resistance training on physical and psychological symptoms of dysmenorrhea. Materials and Methods: 60 nonathletic female collegiate students of Shiraz university participated in this study voluntarily and were divided randomly to 4 groups including 15 persons ( exercise +placebo, exercise + ginger, ginger, and placebo. Ginger groups were prescribed 250 mg of ginger, four times a day for 3 days from beginning of menstruation and placebo groups were recommended the same prescription with 250 mg of placebo drug. Exercise with ginger or placebo groups participated in 2 months of progressive resistance training (3 times a week besides consuming Ginger or placebo drugs. Menstrual symptoms were recorded with using validated questionnaire, before intervention and during two consecutive periods of menstruation. The analysis was performed with using Covariate analysis of variance with repeated measures by SPSS version 16 . Results: A significant reduction was found in physical symptoms of dysmenorrhea in groups of Ginger but no significant statistically changes were found within other groups. Comparison of four groups indicated more significant reduction of physical symptoms in ginger groups compared with other groups. There were no significant difference in psychologic symptoms within and between groups (P>0.05. Conclusion: Ginger is recommended for treatment of physical symptoms of dysmenorrhea.

  2. The effect of pycnogenol on patients with dysmenorrhea using low-dose oral contraceptives

    Science.gov (United States)

    Maia, Hugo; Haddad, Clarice; Casoy, Julio

    2014-01-01

    Objective Menstrual symptoms such as dysmenorrhea usually occur during the hormone-free interval in oral contraceptive users. Progestin withdrawal activates NF-κB transcription factor, which upregulates both vascular endothelial growth factor (VEGF) and Cox-2 expression in the endometrium. The use of natural NF-κB inhibitors such as pycnogenol may block this response, improving dysmenorrhea. Patients and methods Twenty-four patients with severe dysmenorrhea were allocated to one of two treatment groups. In Group A (n=13), women were treated with an oral contraceptive containing 15 μg of ethinyl estradiol and 60 mg of gestodene (Adoless®) in a 24/4 regimen for three consecutive cycles. Women in Group B (n=11) used the same contraceptive regimen together with 100 mg of pycnogenol (Flebon®) continuously for 3 months. Pain scores were graded using a visual analog scale (VAS) before and during the hormone-free interval at the end of the third treatment cycle. Results Before treatment, VAS pain scores for dysmenorrhea were 8 and 9 in Groups A and B, respectively. However, by the end of the third treatment cycle, pain scores had decreased significantly (Pgestodene. PMID:25525393

  3. CROSSECTIONAL STUDY OF PREVALENCE OF DYSMENORRHEA AND PRE MENSTRUAL SYNDROME IN COLLEGE STUDENTS

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    Joylene Diana

    2015-07-01

    Full Text Available Dysmenorrhea or pain during menstruation is the most common gynaecological complaint among adolescents and college students. A good majority of patients with dysmenorrhea also experience pre - menstrual symptoms ( PMS . The objective of this cross s ectional study was to assess prevalence of dysmennorhea , PMS , college absenteeism and knowledge attitudes and practices relating to the same among college going students between the age of 18 to 26 years. METHODS: A cross s ectional analysis of a total of 420 students using questionnaires related to dysmenorrhea was done . The questionnaire dealt with the regularity of menstrual cycles , occurrence of dysmenorrhea , college absenteeism , premenstrual symptoms and lifestyle attributes of the students. RESULTS: The prevalence of dysmenorrhea of varying degrees was found to be as high as 97 percent . Dysmennorhea was seen in 45.8 percent of students with regular cycles and 97.7 percent of students with irregular cycles. 47.5 percentage of students missed their college working days due to menstruation related complaints. Among the students who had pre - menstrual syndrome , majority of them revealed life style attributes like eating fast food and also consuming over the counter pain medicines. Also psychological and emotional changes were commonly seen during the premenstrual phase. CONCLUSION: This study showed that though dysmennorhea of varying degrees is widely prevalent among college going students , the prevalence of pre - menstrual syndrome was higher. The study suggests that adequate counseling and education about menstrual symptoms and abuse of OTC analgesics if made a part of college curriculum as well as lifestyle modifications could come a long way in helping to alleviate the problems college students face due to dysmennorhea and PMS.

  4. Comparative effect of thymus vulgaris and ibuprofen on primary dysmenorrhea: A triple-blind clinical study.

    Science.gov (United States)

    Salmalian, Hajar; Saghebi, Roshanak; Moghadamnia, Ali Akbar; Bijani, Ali; Faramarzi, Mahbobeh; Nasiri Amiri, Fatemeh; Bakouei, Fatemeh; Behmanesh, Fereshte; Bekhradi, Reza

    2014-01-01

    Dysmenorrhea is one of the most common medical problems in gynecology causing several problems in the personal and social life of women. This study was conducted to compare the effect of thymus vulgaris and ibuprofen on the treatment of primary dysmenorrhea Methods: This clinical study was conducted on 84 students of Babol University of Medical Sciences with primary dysmenorrhea. The students were randomly assigned to three groups receiving thymus vulgaris, ibuprofen and placebo. In all three groups, with the beginning of pain, 200 mg capsules and 25 drops of essential oil were given every 6 hours for two consecutive cycles. Pain intensity used the visual scale before and one hour after each dose for 48 hour after starting medication. The data were collected and analyzed. This study was registered in the Iranian Registry of Clinical Trial (www.irct.ir) with registration number ID: IRCT201101245683N1 RESULTS: The mean age of participants was 20.5±1.8 years. Both thymus vulgaris and ibuprofen were effective to reduce the pain severity of dysmenorrhea. Before treatment, the mean pain intensity in thymus vulgaris, ibuprofen and placebo groups were 6.57±2.02, 5.30±2.23 and 6.18±1.78, respectively and after treatment decreased to 1.21±1.06, 1.48±1.62 and 3.54±2.26, respectively. Reduction of pain severity was not statistically significant between the two medications, however it was significant for each drug compared with placebo (pthymus vulgaris as well as ibuprofen can be effective in reducing the severity of pain and spasm in primary dysmenorrhea.

  5. Acupuncture to Treat Primary Dysmenorrhea in Women: A Randomized Controlled Trial

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    Caroline A. Smith

    2011-01-01

    Full Text Available We examined the effectiveness of acupuncture to reduce the severity and intensity of primary dysmenorrhea. A randomized controlled trial compared acupuncture with control acupuncture using a placebo needle. Eligible women were aged 14–25 years with a diagnosis of primary dysmenorrhea. Women received nine sessions of the study treatment over 3 months. The primary outcomes were menstrual pain intensity and duration, overall improvement in dysmenorrhea symptoms and reduced need for additional analgesia, measured at 3, 6 and 12 months from trial entry. A total of 92 women were randomly assigned to the intervention (acupuncture =46 and control =46. At 3 months although pain outcomes were lower for women in the acupuncture group compared with the control group, there was no significant difference between groups. Women receiving acupuncture reported a small reduction in mood changes compared with the control group, relative risk (RR 0.72, 95% confidence interval (CI 0.53–1.00, =.05. Follow-up at 6 months found a significant reduction in the duration of menstrual pain in the acupuncture group compared with the control group, mean difference –9.6, 95% CI –18.9 to –0.3, =.04, and the need for additional analgesia was significantly lower in the acupuncture group compared with the control group, RR 0.69, 95% CI 0.49–0.96, =.03, but the follow-up at 12 months found lack of treatment effect. To conclude, although acupuncture improved menstrual mood symptoms in women with primary dysmenorrhea during the treatment phase, the trend in the improvement of symptoms during the active phase of treatment, and at 6 and 12 months was non-significant, indicating that a small treatment effect from acupuncture on dysmenorrhea may exist. In the study, acupuncture was acceptable and safe, but further appropriately powered trials are needed before recommendations for clinical practice can be made.

  6. A narrative review of medical, chiropractic, and alternative health practices in the treatment of primary dysmenorrhea

    Science.gov (United States)

    Spears, Lolita G.

    2005-01-01

    Abstract Objective Primary dysmenorrhea and related issues are discussed as they influence the gynecological and social health of females during adolescence, adulthood, and senior maturity. Health practitioners are exposed to multiple approaches towards the management of menstrual pain. Clinical and social viewpoints target the causation, development, diagnosis, manifestation and management of primary dysmenorrhea. This narrative review includes the topic of the doctor-patient relationship in efforts of cultivating effectively communicative health practitioners. Controversial topics related to primary dysmenorrhea and the quality of life for women are addressed. Data Sources A search for literature reviews, case studies, laboratory research, and clinical trials from 1985–2004 was performed using the MEDLINE database. Sources of additional information included textbooks, national organizational literature and contemporary articles. Discussion Menstrual pain is a prevalent experience yet it is socially taboo for conversation; as such, it poses a hindrance to its management. The communication between the doctor and patient is a critical barrier point between establishing a diagnosis and determining an appropriate treatment plan. A multi-disciple treatment plan varies as much as patients themselves vary in personal experiences, needs, and preferences. Conclusions Medicinal prophylactics, physical therapeutics, non-acidic diets, herbal supplements, eastern therapies and the chiropractic manual adjustments of the spine are effective methods for the management of primary dysmenorrhea. The non-invasive management of primary dysmenorrhea includes the chiropractic adjustment with complimentary modalities, and other alternative health care practices. Medicinal prophylactics are invasive and pose a higher risk to long-term chemical exposure, side effects or irreversible conditions. PMID:19674650

  7. The effect of vitamin D on primary dysmenorrhea with vitamin D deficiency: a randomized double-blind controlled clinical trial.

    Science.gov (United States)

    Moini, Ashraf; Ebrahimi, Tabandeh; Shirzad, Nooshin; Hosseini, Reihaneh; Radfar, Mania; Bandarian, Fatemeh; Jafari-Adli, Shahrzad; Qorbani, Mostafa; Hemmatabadi, Mahboobeh

    2016-06-01

    Dysmenorrhea is common among women of reproductive age. This study aim was to investigate the effect of vitamin D (vit D) supplementation in treatment of primary dysmenorrhea with vit D deficiency. A randomized double-blind placebo-controlled clinical trial was conducted on 60 women with primary dysmenorrhea and vit D deficiency referred to our clinic at Arash Women's Hospital from September 2013 to December 2014. Eligible women were randomly assigned into treatment and control groups (30 in each group). Individuals in the treatment group received 50 000 IU oral vit D and the control group received placebo weekly for eight weeks. After two months of treatment, there was a significant difference in serum vit D concentration between the two groups (p D supplementation for eight weeks in patients with primary dysmenorrhea and vit D deficiency could improve pain intensity.

  8. The Severity of Dysmenorrhea and its Relationship with Body Mass Index among Female Adolescents in Hamadan, Iran

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    Batool Khodakarami

    2015-09-01

    Full Text Available Background & aim: Primary dysmenorrhea is a common problem among women, resulting in a decline in their performance level and quality of life. Previous studies have not indicated a definite relationship between body mass index (BMI and dysmenorrhea. Therefore, this study aimed to determine the severity of dysmenorrhea and investigate its relationship with BMI among female adolescents in Hamadan, Iran. Methods:This cross-sectional study was conducted on 579 single, female adolescents in schools of Hamadan, Iran in 2011. Students with primary dysmenorrhea (without any other conditions were selected, using random cluster sampling. Demographic characteristics and menstrual cycle information were collected, using two separate questionnaires. BMI was recorded in all participants and visual analogue scale was applied for pain assessment. Chi-square, t-test, Fisher's exact test and logistic regression were used to examine the relationship between variables. Data were analyzed, using SPSS version 16. P-value less than 0.05 was considered statistically significant. Results: The mean age, BMI and age at menarche in participants were 15.94±1.17 years, 21.16±3.36 kg/m2 and 12.92± 1.05 years, respectively. The frequency of dysmenorrhea was estimated to be 85.31%. The frequency and severity of dysmenorrhea was higher in the normal-weight group than other subjects. No relationship was seen between the severity and duration of dysmenorrhea with BMI. But dysmenorrhea had a significant relationship with age at menarche and premenstrual syndrome (P

  9. Levonorgestrel-releasing IUD versus copper IUD in control of dysmenorrhea, satisfaction and quality of life in women using IUD

    OpenAIRE

    Seyed Javad Purafzali Firuzabadi; Toktam Tavakolianfar; Mamak Shariat; Fatemeh Ramazanzadeh; Fedieh Hagholahi

    2012-01-01

    Background: The levonorgestrel-releasing IUD can help the treatment of dysmenorrhea by reducing the synthesis of endometrial prostaglandins as a conventional treatment. Objective: This study was performed to assess the frequency of dysmenorrhea, satisfaction and quality of life in women using Mirena IUDs as compared to those using copper IUDs. Materials and Methods: This double-blind randomized clinical trial was performed between 2006 and 2007 on 160 women aged between 20 to 35 years who att...

  10. Comparing Hemorrhages and Dysmenorrhea with Copper T380A and Multiload 375 Intrauterine Devices: A Randomized Clinical Trial

    OpenAIRE

    Shahnazi, Mahnaz; Sarrafi, Somayyeh; Asgari Jafarabadi, Mohammad; Azari, Sahar; Esmaili, Fariba

    2014-01-01

    Introduction: One of the most common complications of IUD users is bleeding and dysmenorrhea. These complications vary in the different types of IUDs. The aim of this study was to compare the bleeding and dysmenorrhea in ML CU 375 IUD and Copper T 380A IUD. Methods: This randomized double-blind controlled clinical trial was performed on 48 women in a health care centres from January to October 2012, in Tabriz, Iran. Participants allocated into two equal groups of receiving I...

  11. Comparing the analgesic effect of heat patch containing iron chip and ibuprofen for primary dysmenorrhea: a randomized controlled trial

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    Navvabi Rigi Shahindokht

    2012-08-01

    Full Text Available Abstract Background Primary dysmenorrhea is a common and sometimes disabling condition. In recent years, some studies aimed to improve the treatment of dysmenorrhea, and therefore, introduced several therapeutic measures. This study was designed to compare the analgesic effect of iron chip containing heat wrap with ibuprofen for the treatment of primary dysmenorrhea. Methods In this randomized (IRCT201107187038N2 controlled trial, 147 students (18–30 years old with the diagnosis of primary dysmenorrhea were enrolled considering the CONSORT guideline. Screening for primary dysmenorrhea was done by a two-question screening tool. The participants were randomly assigned into one of the intervention groups (heat Patch and ibuprofen. Data regarding the severity and emotional impact of the pain were recorded by a shortened version of McGill Pain Questionnaire (SF-MPQ. Student's t test was used for statistical analysis. Results The maximum and minimum pain severities were observed at 2 and 24 hours in both groups. The severity of sensual pain at 8, 12, and 24 hours was non-significantly less in the heat Patch group. There was also no significant difference between the groups regarding the emotional impact of pain at the first 2, 4, 8, 12 and 12 hours of menstruation. Conclusions Heat patch containing Iron chip has comparable analgesic effects to ibuprofen and can possibly be used for primary dysmenorrhea. Trial registration IRCT201107187038N2

  12. The Effects of Medicinal Plants of Melissa officinalis and Salvia officinalis on Primary Dysmenorrhea

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    R. Kalvandi

    2014-07-01

    Full Text Available Introduction & Objective: Primary dysmenorrhea is one of the common problems in women, especially in young women. Although dysmenorrhea is not life threatening , it can have ad-verse effect on quality of life and cause disability or ineffectiveness. With regard to the young society suffering from it, various treatments are offered for dysmenorrhea one of which is medicinal plants. This study investigated the effect of Melissa officinalis and Salvia officinalis on primary dysmenorrhea Materials & Methods: This study was a clinical trial study performed on 50 girls with dys-menorrheal taking Salvia officinalis as infusion for five days before menstruation and five days during the menstruation. The consumption of the plants was repeated in the next two periods in the same way. Severity of pain, blooding duration and dysmenorrhea duration were evaluated with VAS (Visual Analog Scale Questionnaire in their next two cycles. Data were analyzed by chi-square, t-test and WILCOXON statistical test. Results: The results of this study showed that after using the plants, pain severity and pain duration significantly reduced P<0.01so that pain severity decreased from 6.30 to 3.94 and 3.24, (on a scale of 1 to 10 after taking the plants in the first and second periods ,respectively. The maximum pain duration before the treatment was 1 to 6 h (28.6% and this number reduced to less than 1 h after using these medicinal plants (38.0%. Mean of blooding duration was 6.36 days before the treatment. After the first and second duration, this value reached 6.48 and 6.34 days, respectively. It was determined that taking oral seda-tives reduced from 56% to 26% and 22% after the first and second periods, respectively. Fi-nally, after the second period, 42% of the girls reported high rates of satisfaction because of using the medicinal plants. Conclusion: Generally, it was showed that Melissa officinalis and Salvia officinalis signifi-cantly reduced pain severity and pain

  13. Ear Acupuncture Therapy for 37 Cases of Dysmenorrhea Due to Endometriosis

    Institute of Scientific and Technical Information of China (English)

    向东方; 司徒仪; 梁雪芳; 程兰; 章国来

    2002-01-01

    @@ Endometriosis (EMT) is one of the difficult and complicated cases in gynecology, and its incidence shows a tendency to go up year by year. It is mainly manifested in clinic as dysmenorrhea, acyesis, irregular menstruation and pelvic lumps. Dysmenorrhea is the most characteristic symptom of endometriosis and its relief has important significance in the treatment of the disease. Certain hormonal drugs, such as danazol and gestrinone, exhibit convincing therapeutic effects but with obvious adverse actions. Operative therapy has also some limitations. Since 1997, the disorder has been treated by our special department for endometriosis with ear acupuncture therapy. Meanwhile, a group of patients were treated as controls with the decoction of traditional Chinese drugs for activating blood circulation and removing stasis. The results are reported as follows.

  14. Autistic traits in women with primary dysmenorrhea: a case–control study

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    Toy H

    2016-09-01

    Full Text Available Harun Toy,1 Arzu Hergüner,2 Sevcan Şimşek,1 Sabri Hergüner3 1Department of Obstetrics and Gynecology, Meram Faculty of Medicine, Necmettin Erbakan University, 2Child and Adolescent Psychiatry Clinic, Konya Training and Research Hospital, 3Department of Child and Adolescent Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey Objectives: Recent studies have shown that women with autism spectrum disorder have higher rates of menstrual problems, including irregular menstrual cycles, unusually painful periods (dysmenorrhea, and excessive menstrual bleeding. In this study, we investigated the autistic traits in female university students with primary dysmenorrhea (PD. Methods: Seventy females with PD and 70 females without PD were enrolled in the study. The Autism Spectrum Quotient (AQ was used to measure autistic traits and the Brief Symptom Inventory was used for evaluating anxiety and depression levels. The dysmenorrheal pain was assessed by visual analog scale (VAS, coded from 0 to 10. Weight and height were measured, and the body mass index was calculated. Results: There were no statistical differences between the groups in terms of age, duration of education, and body mass index. Women with PD had higher AQ – Total, and AQ – Attention Switching subscale scores than subjects without PD. Spearman analysis revealed that AQ – Total and AQ – Attention Switching scores were correlated with VAS. According to the linear regression analysis, VAS was predicted only by AQ – Attention Switching subscale. Conclusion: Our findings showed an association between autistic traits and dysmenorrhea in typically developing females. Keywords: primary dysmenorrhea, autistic traits, androgens

  15. Dysmenorrhea among female medical students in King Abdulaziz University: Prevalence, Predictors and outcome

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    Ibrahim, Nahla Khamis; AlGhamdi, Manar Saleh; Al-Shaibani, Alanoud Nawaf; AlAmri, Fatima Ali; Alharbi, Huda Abdulrahman; Al-Jadani, Arwa Kheder; Alfaidi, Raghad Ahmed

    2015-01-01

    Objective: To determine the prevalence, predictors and outcome of dysmenorrhea among female medical students in King Abdulaziz University (KAU), Jeddah, Saudi Arabia. Methods: A cross-sectional study was conducted among 435 medical students at KAU, Jeddah selected through stratified random sample method. A pre-constructed, validated, self-administered questionnaire was used to collect personal and socio-demographic information. Data about menstrual history, stress, smoking were also collected...

  16. Efficacy of Oral Ginger (Zingiber officinale for Dysmenorrhea: A Systematic Review and Meta-Analysis

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    Chen X. Chen

    2016-01-01

    Full Text Available This systematic review examines the efficacy of oral ginger for dysmenorrhea. Key biomedical databases and grey literature were searched. We included randomized controlled trials comparing oral ginger against placebo or active treatment in women with dysmenorrhea. Six trials were identified. Two authors independently reviewed the articles, extracted data, and assessed risk of bias. Discrepancies were resolved by consensus with a third reviewer. We completed a narrative synthesis of all six studies and exploratory meta-analyses of three studies comparing ginger with placebo and two studies comparing ginger with a nonsteroidal anti-inflammatory drug (NSAID. Ginger appeared more effective for reducing pain severity than placebo. The weighted mean difference on a 10 cm visual analogue scale was 1.55 cm (favoring ginger (95% CI 0.68 to 2.43. No significant difference was found between ginger and mefenamic acid (an NSAID. The standardized mean difference was 0 (95% CI −0.40 to 0.41. Available data suggest that oral ginger could be an effective treatment for menstrual pain in dysmenorrhea. Findings, however, need to be interpreted with caution because of the small number of studies, poor methodological quality of the studies, and high heterogeneity across trials. The review highlights the need for future trials with high methodological quality.

  17. A clinical comparative study of oral and topical ginger on severity and duration of primary dysmenorrhea

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    P. Shirooye

    2017-01-01

    Full Text Available Background and objectives: Primary dysmenorrhea has remained a health problem. This study has compared the effect of oral and topical ginger on severity and duration of primary dysmenorrhea.  Methods: A single-blind randomized trial was conducted on 70 female students with moderate and severe primary dysmenorrhea. The participants were stratified randomized between two groups of oral and topical ginger. The oral group received 250 mg capsules of ginger powder and the topical group applied five drops of ginger oil topically every 6 hours from two days before through the first three days of menstruation for three cycles. The severity and duration of pain, and the number of mefenamic acid consumption were assessed in each cycle. Before-after changes were evaluated in each group and were compared between two groups. Results: The reduction of pain severity was 3(±3.2 in the topical compared to 2.6(±3.4 in the oral group (p

  18. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.

    Science.gov (United States)

    Nikkhah, Somayeh; Dolatian, Mahrokh; Naghii, Mohammad Reza; Zaeri, Farid; Taheri, Seyed Mojtaba

    2015-05-01

    Primary dysmenorrhea refers to painful menstrual cramps without pelvic pathology. The condition is highly prevalent among women and exerts negative effects on their quality of life. Considering the evidence for anti-inflammatory properties of Boron, the present study aimed to determine the effects of Boron supplementation on the severity and duration of menstrual pain in female university students. This triple-blind randomized clinical trial study recruited 113 university students. The participants were matched for the severity and duration of dysmenorrhea and randomly allocated into the case and control groups (n = 58 and 55, respectively). The case group consumed 10 mg/day Boron from two days before the menstrual flow until its third day. The control group received placebo capsules (similar to those distributed among the cases). All subjects were asked to take the capsules for two consecutive menstrual cycles. Pain severity (measured on a visual analog scale) and duration (in hours) were measured at baseline and during the two cycles. The two groups had no significant differences in the severity and duration of pain at baseline. After the intervention, however, the severity and duration of pain were significantly lower in the case group than in the control group (P Boron supplementation can reduce the severity and duration of menstrual pain through exerting anti-inflammatory effects. In order to clarify the effects of Boron on dysmenorrhea, future studies are required to measure the levels of hormones and inflammatory biomarkers. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Management of primary dysmenorrhea in young women with frameless LNG-IUS

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    Wildemeersch D

    2014-06-01

    Full Text Available Dirk Wildemeersch,1 Sohela Jandi,2 Ansgar Pett,2 Thomas Hasskamp3 1Gynecological Outpatient Clinic and IUD Training Center, Ghent, Belgium; 2Gynecological Outpatient Clinic, Berlin, Germany; 3GynMünster, Münster, Germany Abstract: The objective of this paper is to discuss the potential advantages of intrauterine treatment with a frameless levonorgestrel (LNG-releasing intrauterine system (IUS in young women presenting with primary dysmenorrhea associated with heavy menstrual bleeding. The paper is based on clinical reports of 21 cases of primary and secondary dysmenorrhea treated with the frameless LNG-IUS. Three typical examples of young women between 16 and 20 years of age, who presented with moderate-to-severe primary dysmenorrhea associated with heavy menstrual bleeding, are presented as examples. Following pelvic examination, including vaginal sonography, a frameless LNG-IUS, releasing 20 µg of LNG/day, was inserted. The three patients developed amenorrhea, or scanty menstrual bleeding, and absence of pain complaints within a few months. We conclude that continuous, intrauterine progestogen delivery could be a treatment of choice of this inconvenient condition. In addition, the good experiences with the frameless LNG-IUS in other studies suggests that the frameless design may be preferred over a framed LNG-IUS, as the absence of a frame, resulting in optimal tolerance, is particularly advantageous in these women. Keywords: heavy menstrual bleeding, contraception, FibroPlant, intrauterine system

  20. Prevalence of dysmenorrhea in university students in Turkey: effect on daily activities and evaluation of different pain management methods.

    Science.gov (United States)

    Potur, Dilek Coskuner; Bilgin, Nevin Citak; Komurcu, Nuran

    2014-12-01

    This study was conducted to determine the following among a group of female university students: the prevalence of dysmenorrhea; pain severity ratings; methods used to manage dysmenorrhea; and the effect of dysmenorrhea on daily activities, school attendance, and ability to communicate with friends. This cross-sectional study was conducted between December 2009 and February 2010 at a public university located in Istanbul, in the northwest area of Turkey. The study group included 1515 female students. Data were collected from the female students in the study group using a self-report questionnaire; the severity of dysmenorrhea was determined with the visual analog scale. The data were examined with mean, percentages, chi-square analysis, and logistic regression. The prevalence of dysmenorrhea in the study group was 85.7%. Of this group of subjects with dysmenorrhea, 30.4% described their menstrual pain as severe, 49.8% as moderate, and 19.8% as mild. The mean severity of pain among the students was 6.33 ± 2.32 on the VAS. The majority of participants who experienced moderate or severe pain regularly used analgesics for pain management, and participants who experienced severe pain used analgesics before the beginning of menstruation. Participants who experienced moderate pain used herbal tea, massage, heat application, rest, and distraction for pain management. Participants who experienced severe pain consulted a physician and that a significant difference existed between the dysmenorrhea rating groups in this regard (p pain was significantly associated with school absenteeism and limitations in social activities/functioning (p students and is related to school absenteeism, ability to participate in and enjoy daily activities, and limitations in social activities/functioning.

  1. Levonorgestrel-releasing IUD versus copper IUD in control of dysmenorrhea, satisfaction and quality of life in women using IUD

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    Seyed Javad Purafzali Firuzabadi

    2012-01-01

    Full Text Available Background: The levonorgestrel-releasing IUD can help the treatment of dysmenorrhea by reducing the synthesis of endometrial prostaglandins as a conventional treatment. Objective: This study was performed to assess the frequency of dysmenorrhea, satisfaction and quality of life in women using Mirena IUDs as compared to those using copper IUDs.Materials and Methods: This double-blind randomized clinical trial was performed between 2006 and 2007 on 160 women aged between 20 to 35 years who attended Shahid Ayat Health Center of Tehran, and they were clients using IUDs for contraception. 80 individuals in group A received Mirena IUD and 80 individuals in group B received copper (380-A IUD. Demographic data, assessment of dysmenorrhea, and follow-up 1, 3 and 6 months after IUD replacement were recorded in questionnaires designed for this purpose. To assess the quality of life, SF36 questionnaire was answered by the attending groups, and to assess satisfaction, a test with 3 questions was answered by clients. Results: Dysmenorrhea significantly was decreased in both groups six months after IUD insertion as compared to the first month (p<0.001. However, statistically, Mirena reduced dysmenorrhea faster and earlier compared to cupper IUD (p<0.003. There isn’t any significant difference between these two groups in satisfaction and quality of life outcomes. Conclusion: There is no difference between these two groups in terms of the satisfaction and quality of life, therefor the usage of Mirena IUD is not a preferred contraception method.

  2. Efficacy of Acupuncture versus Combined Oral Contraceptive Pill in Treatment of Moderate-to-Severe Dysmenorrhea: A Randomized Controlled Trial

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    Intira Sriprasert

    2015-01-01

    Full Text Available This open-label randomized controlled trial was designed to compare the efficacy of acupuncture and combined oral contraceptive (COC pill in treating moderate-to-severe primary dysmenorrhea. Fifty-two participants were randomly assigned to receive either acupuncture (n = 27 or COC (n = 25 for three menstrual cycles. Mefenamic acid was prescribed as a recue analgesic drug with both groups. The statistical approach used for efficacy and safety assessments was intention-to-treat analysis. By the end of the study, both treatments had resulted in significant improvement over baselines in all outcomes, that is, maximal dysmenorrhea pain scores, days suffering from dysmenorrhea, amount of rescue analgesic used, and quality of life assessed by SF-36 questionnaire. Over the three treatment cycles, COC caused greater reduction in maximal pain scores than acupuncture, while improvements in the remaining outcomes were comparable. Responders were defined as participants whose maximal dysmenorrhea pain scores decreased at least 33% below their baseline. Response rates following both interventions at the end of the study were not statistically different. Acupuncture commonly caused minimal local side effects but did not cause any hormone-related side effects as did COC. In conclusion, acupuncture is an alternative option for relieving dysmenorrhea, especially when COC is not a favorable choice.

  3. More Than Needles: The Importance of Explanations and Self-Care Advice in Treating Primary Dysmenorrhea with Acupuncture

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    Michael Armour

    2016-01-01

    Full Text Available Background. Primary dysmenorrhea is a common gynaecological condition. Traditional Chinese medicine (TCM acupuncturists commonly treat primary dysmenorrhea and dispense specific self-care advice for this condition. The impact of self-care advice on primary dysmenorrhea is unknown. Methods. 19 TCM acupuncture practitioners from New Zealand or Australia and 12 New Zealand women who had recently undergone acupuncture treatment for primary dysmenorrhea as part of a randomised controlled trial participated in this qualitative, pragmatic study. Focus groups and semistructured interviews were used to collect data. These were recorded, transcribed, and analysed using thematic analysis. Results. The overarching theme was that an acupuncture treatment consisted of “more than needles” for both practitioners and participants. Practitioners and participants both discussed the partnership they engaged in during treatment, based on openness and trust. Women felt that the TCM self-care advice was related to positive outcomes for their dysmenorrhea and increased their feelings of control over their menstrual symptoms. Conclusions. Most of the women in this study found improved symptom control and reduced pain. A contributing factor for these improvements may be an increased internal health locus of control and an increase in self-efficacy resulting from the self-care advice given during the clinical trial.

  4. Side effects of glyceryl trinitrate ointment for primary dysmenorrhea: a randomized clinical trial

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    Rahnama P.

    2008-03-01

    Full Text Available Background: Patch forms of glyceryl trinitrate (GTN, also known as nitroglyceril, have proved useful in the management of dysmenorrhea. Increased intrauterine pressure due to exaggerated myometrial contractions is an important factor in the pathogenesis of dysmenorrhea. In a recent study, it was found that GTN caused a significant reduction in the contraction frequency of human myometrial strips. The object of this study is to evaluate the efficacy of GTN ointment in treating primary dysmenorrhea.Methods: In this double-blind randomized placebo-controlled study, we enrolled 112 unmarried subjects with the complaint of moderate to severe primary dysmenorrhea. They were between 18-30 years of age with normal BMI (19-27 and all had normal results upon examination by pelvic ultrasound. None of these patients had a history anemia, previous pelvic surgery or cardiovascular diseases. Randomly divided in two groups using odd and even numbers, 56 of the subjects received 5 mg 1% GTN ointment and another 56 received a placebo. Before starting the treatment, severity of pain was recorded using a visual scale method. Ointment A (GTN 1% or ointment B (placebo was applied to special papers which were in turn applied to the skin of the abdomen below the umbilicus, and left there for the entire treatment period of four hours. The severity of pain and side effects of the treatment were recorded at intervals of 15 min, 30 min, 1 h, 2 h and 4 h after application the treatment. After four hours, the treatment was removed and the skin checked for erythema. Results: There was no difference in severity of pain 15 min after treatment, but pain was less severe in the GTN group from the 30-min interval through the 4-h interval, with the least pain felt at the 2-h interval. This decrease in pain lasted through the 4-h interval. Side effects, which were more common in the GTN group than the placebo group (P<0.05, included headache (48.3% vs. 19.5%, respectively, dizziness

  5. The effect of pycnogenol on patients with dysmenorrhea using low-dose oral contraceptives

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    Maia Jr H

    2014-12-01

    Full Text Available Hugo Maia Jr, Clarice Haddad, Julio Casoy Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH, Salvador, Bahia, BrazilObjective: Menstrual symptoms such as dysmenorrhea usually occur during the hormone-free interval in oral contraceptive users. Progestin withdrawal activates NF-κB transcription factor, which upregulates both vascular endothelial growth factor (VEGF and Cox-2 expression in the endometrium. The use of natural NF-κB inhibitors such as pycnogenol may block this response, improving dysmenorrhea.Patients and methods: Twenty-four patients with severe dysmenorrhea were allocated to one of two treatment groups. In Group A (n=13, women were treated with an oral contraceptive containing 15 µg of ethinyl estradiol and 60 mg of gestodene (Adoless® in a 24/4 regimen for three consecutive cycles. Women in Group B (n=11 used the same contraceptive regimen together with 100 mg of pycnogenol (Flebon® continuously for 3 months. Pain scores were graded using a visual analog scale (VAS before and during the hormone-free interval at the end of the third treatment cycle.Results: Before treatment, VAS pain scores for dysmenorrhea were 8 and 9 in Groups A and B, respectively. However, by the end of the third treatment cycle, pain scores had decreased significantly (P<0.05 both in groups A and B. The final pain scores were 6 in Group A and 2 in Group B, a difference that was statistically significant (P<0.0001. In Group B, 27% of the patients became pain-free, while in Group A, none of the women reported complete disappearance of this symptom. The number of bleeding days was also lower in Group B.Discussion: Pycnogenol effectively decreased pain scores and the number of bleeding days when administered concomitantly with a low-dose 24/4 oral contraceptive containing gestodene.Keywords: gestodene, hormone-free interval, pain

  6. Comparing the effects of aerobic and stretching exercises on the intensity of primary dysmenorrhea in the students of universities of bushehr.

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    Farideh Vaziri

    2015-03-01

    Full Text Available To compare the effects of aerobic and stretching exercises on severity of primary dysmenorrhea.This randomized clinical trial was conducted on 105 female students who were suffering from primary dysmenorrhea. The participants were divided into aerobic exercise, stretching exercise, and control groups. The two intervention groups did the exercises three times a week for eight weeks (two menstrual cycles. The intensity of dysmenorrhea was determined using a modified questionnaire that assessed several symptoms of dysmenorrhea. After all, the data were compared between and within groups through analysis of variance.Before the intervention, the mean intensity of dysmenorrhea was 40.38 ± 5.5, 37.40 ± 3.8, and 38.45±3.3 in aerobic, stretching, and control groups, respectively, but the difference was not statistically significant. After the intervention, however, a significant difference was found among the three groups regarding the mean intensity of dysmenorrhea in the first and second menstrual cycles. Also, a significant difference was observed between the aerobic group and the control group as well as between the stretching group and the control group. Within group comparisons showed a significant difference in the aerobic and the stretching group before and after the interventions. However, no such difference was observed in control group.Both aerobic and stretching exercises were effective in reducing the severity of dysmenorrhea. Therefore, women could choose one of these two methods with regard to their interest and lifestyle.

  7. Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea.

    Science.gov (United States)

    Akin, Mark; Price, William; Rodriguez, Gonzalo; Erasala, Geetha; Hurley, George; Smith, Roger P

    2004-09-01

    To determine if pain relief provided by a wearable heat wrap (continuous, low-level, topical heat therapy) is superior to oral acetaminophen for primary dysmenorrhea. A randomized, active-controlled, multisite, single-blind (investigator), parallel-design study compared an abdominal wrap to an oral medication (acetaminophen, 1000 mg) over I day. Pain relief (0-5) and abdominal muscle tightness/cramping (0-100) were recorded at 12 time points. At 24 and 48 hours, menstrual symptom-based quality of life was assessed. Three hundred sixty-seven subjects entered the study, with 344 subjects evaluable. The heat wrap was superior to acetaminophen for pain relief over an 8-hour period (means of 2.48 and 2.17, p = 0.015) and at t hours 3, 4, 5 and 6 (p means of 40.4 and 44.5, p = 0.04) and at hours 4, 5 and 6 (p lower abdominal cramping (p < or = 0.05) with heat therapy. Continuous, low-level, topical heat therapy was superior to acetaminophen for the treatment of dysmenorrhea.

  8. Systematic Review of Randomized Clinical Trials of Acupressure Therapy for Primary Dysmenorrhea

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    Hui-ru Jiang

    2013-01-01

    Full Text Available The evidence of acupressure is limited in the management of dysmenorrhea. To evaluate the efficacy of acupressure in the treatment of primary dysmenorrhea based on randomized controlled trials (RCTs, we searched MEDLINE, the Chinese Biomedical Database (CBM, and the Cochrane Central Register of Controlled Trials (CENTRAL databases from inception until March 2012. Two reviewers independently selected articles and extracted data. Statistical analysis was performed with RevMan 5.1 software. Eight RCTs were identified from the retrieved 224 relevant records. Acupressure improved pain measured with VAS (−1.41 cm 95% CI [−1.61, −1.21], SF-MPQ at the 3-month followup (WMD −2.33, 95% CI [−4.11, −0.54] and 6-month followup (WMD −4.67, 95% CI [−7.30, −2.04], and MDQ at the 3-month followup (WMD −2.31, 95% CI [−3.74, −0.87] and 6-month followup (WMD −4.67, 95% CI [−7.30, −2.04]. All trials did not report adverse events. These results were limited by the methodological flaws of trials.

  9. Application of Acupoints and Meridians for the Treatment of Primary Dysmenorrhea: A Data Mining-Based Literature Study

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    Siyi Yu

    2015-01-01

    Full Text Available Background. Dysmenorrhea is a common problem for which acupuncture provides effective analgesia. Although acupoint selection affects the effectiveness of acupuncture, the basic rules of acupoint selection are little understood. This study aims to investigate the principles of acupoint selection and characteristics of acupoints used for primary dysmenorrhea. Methods. PubMed, China National Knowledge Infrastructure, and Chinese Biomedical Database were searched for clinical trials published in English or Chinese from January 1978 to April 2014 evaluating the effect of acupuncture on primary dysmenorrhea, with or without methods of randomization and/or control. Three authors extracted information and two reviewers inputted information on titles, journals, interventions, main acupoints, and outcomes using the self-established Data Excavation Platform of Acupoint Specificity for data mining. Results. Sanyinjiao (SP06, Guanyuan (CV04, and Qihai (CV06 were used most frequently. The most frequently used meridians were Conception Vessel, Spleen Meridian of Foot Taiyin, and Bladder Meridian of Foot Taiyang. 67.24% of acupoints used were specific acupoints. Acupoints on lower limbs were most frequently used. Conclusion. Data mining is a feasible approach to identify the characteristics of acupoint selection. Our study indicated that modern acupuncture treatment for primary dysmenorrhea is based on selection of specific acupoints according to traditional acupuncture theory.

  10. Effect of Hominis placenta Pharmacopuncture on the Dysmenorrhea (A Pilot study, Single blind, Randomized, Controlled Clinical Trial

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    Su-Min Kim

    2008-09-01

    Full Text Available Objective : This study was designed to evaluate the effect of Hominis placenta Pharmacopuncture treatment on Dysmenorrhea of Women. Methods : 49 subjects who were suffering from dysmenorrhea volunteered to answer the MMP(Measure of Menstrual Pain and MSSL(Menstrual Symptom Severity List questionnaire. They were divided into two groups, a Hominis placenta Pharmacopuncture treatment group(Experiment al group, n=25 and a Normal Saline(N/S treatment group(Control group, n=24. The two groups were injected on the CV4, S36, Sp9 and Sp6 acupuncture point. They were treated totally five times depending on the individual menstruation cycles. The scores of MMP and MSSL were measured overall three times before and after the menstruation cycle. The collected data were analyzed as paired t-test, independent t-test using SPSS 12.0 WIN Program. Results : As a result of the evaluation by MMP and MSSL, a significant improvement on dysmenorrhea was made in the two groups(p<0.05, and both scores of Experiment group were decreased more than Control group. But there was no significant difference between the two groups. Conclusions : The Hominis placenta Pharmacopuncture treatment and the Normal Saline treatment were effective in decreasing the symptom of Dysmenorrhea.

  11. Comparison the Effect of Mefenamic Acid and Matricaria Chamomilla on Primary Dysmenorrhea in Kashan Medical University Students

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    Zahra Karimian

    2013-12-01

    Full Text Available Background & Objectives: Regarding to high incidence of dysmenorrhea and influence on daily activities and fewer side effects of herbal medicines than chemical drugs, the aim of this study was to compare the effect of mefenamic acid and matricaria chamomilla (MC on primary dysmenorrhea.   Methods: This triple-blind randomized clinical trial study was done on 90 female students residents in dormitories of Kashan University of Medical Sciences in 2012. The subjects were categorized into two groups randomly. Mefenamic acid capsules (250 mg, every 8 hours were given to the first group from 48 hours before menstruation until 24 hours after it. The second group received MC capsules made in Barij Essence Factory of Kashan (250 mg, every 8 hours. Severity of dysmenorrhea was measured by McGill ruler. Finally, the data were analyzed by SPSS. The chi-squire, fisher and paired t-test were used. The p-value of less than 0.05 was considered as statistically significant difference.   Results: The result of this study indicated that both chamomilla and mefenamic acid can reduce the severity of pain and hemorrhage (p0.05.   Conclusion: This study showed that matricaria chamomilla is effective in decreasing the severity of primary dysmenorrhea and reducing hemorrhage as well as mefenamic acid.

  12. Dismenorreia membranosa: uma doença esquecida Membranous dysmenorrhea: a forgotten disease

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    Patrícia Pereira de Oliveira

    2009-06-01

    Full Text Available OBJETIVO: apresentar uma série de casos de dismenorreia membranosa. MÉTODOS: todas as pacientes foram selecionadas a partir da suspeição diagnóstica, após atendimento clínico em consultório privado por relato de dismenorreia dolorosa associada à eliminação espontânea de material elástico com formato semelhante a útero. Apenas fatos relevantes foram descritos do quadro álgico, história médica atual e pregressa e hábitos de vida. O material eliminado foi encaminhado para laboratório de patologia no qual ocorreu a análise macro e microscópica. Os casos em que não se pode provar a eliminação de material com característica membranácea não foram selecionados. Após a confirmação diagnóstica, realizou-se uma revisão da literatura até o ano de 2008 utilizando o método MeSH com o termo "membranous dysmenorrhea". RESULTADOS: três casos clínicos de dismenorreia foram transcritos. Todos os casos, além do quadro característico de dor e eliminação vaginal de material elástico, foram associados ao uso de métodos anticoncepcionais hormonais. CONCLUSÕES: embora haja apenas escassos relatos de caso de dismenorreia membranosa na literatura científica, sua etiologia deve ser suspeita em casos de dor associada a sangramento vaginal com eliminação de material elástico ou firme. O diagnóstico final é dependente do exame anatomopatológico que nunca deve ser dispensado. Observamos necessidade de mais discussões sobre esta patologia com o objetivo de manter o profissional atualizado para exercer diagnóstico e terapêutica adequados.PURPOSE: to present a series of cases of membranous dysmenorrhea. METHODS: all the patients selected were under diagnostic suspicion, after being clinically attended in a private medical office due to the report of painful dysmenorrhea associated with spontaneous elimination of elastic material with uterine shape. Only relevant facts about the pain condition have been described, together with

  13. Some physiotherapy treatments may relieve menstrual pain in women with primary dysmenorrhea: a systematic review

    Directory of Open Access Journals (Sweden)

    Priya Kannan

    2014-03-01

    Full Text Available Question: In women with primary dysmenorrhoea, what is the effect of physiotherapeutic interventions compared to control (either no treatment or placebo/sham on pain and quality of life? Design: Systematic review of randomised trials with meta-analysis. Participants: Women with primary dysmenorrhea. Intervention: Any form of physiotherapy treatment. Outcome measures: The primary outcome was menstrual pain intensity and the secondary outcome was quality of life. Results: The search yielded 222 citations. Of these, 11 were eligible randomised trials and were included in the review. Meta-analysis revealed statistically significant reductions in pain severity on a 0–10 scale from acupuncture (weighted mean difference 2.3, 95% CI 1.6 to 2.9 and acupressure (weighted mean difference 1.4, 95% CI 0.8 to 1.9, when compared to a control group receiving no treatment. However, these are likely to be placebo effects because when the control groups in acupuncture/acupressure trials received a sham instead of no treatment, pain severity did not significantly differ between the groups. Significant reductions in pain intensity on a 0–10 scale were noted in individual trials of heat (by 1.8, 95% CI 0.9 to 2.7, transcutaneous electrical nerve stimulation (2.3, 95% CI 0.03 to 4.2, and yoga (3.2, 95% CI 2.2 to 4.2. Meta-analysis of two trials of spinal manipulation showed no significant reduction in pain. None of the included studies measured quality of life. Conclusion: Physiotherapists could consider using heat, transcutaneous electrical nerve stimulation, and yoga in the management of primary dysmenorrhea. While benefits were also identified for acupuncture and acupressure in no-treatment controlled trials, the absence of significant effects in sham-controlled trials suggests these effects are mainly attributable to placebo effects. [Kannan P, Claydon LS (2014 Some physiotherapy treatments may relieve menstrual pain in women with primary dysmenorrhea: a

  14. Effects of Acupressure and Ibuprofen on the Severity of Primary Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ The present study aims at comparing the effects of acupressure using new combination of acupoints, and Ibuprofen on the severity of primary dysmenorrhea (PD). 216 female high school students, aged between 14 to 18 years, were randomly selected and divided into three groups. Each group underwent different treatment techniques: acupressure, Ibuprofen and sham acupressure as a placebo. The results indicated that the three therapeutic techniques were significantly effective in reducing the pain. However the therapeutic efficacies of acupressure and Ibuprofenwere similar with no significant difference, and were significantly better thanthe placebo. Thus acupressure, with no complications, is recommended as an alternative and also a better choice in the decrease of the severity of PD.

  15. Simultaneous objective and subjective evaluation of meclofenamate sodium in the treatment of primary dysmenorrhea.

    Science.gov (United States)

    Smith, R P; Powell, J R

    1987-09-01

    Eighteen patients participated in a double-blind, placebo-controlled, single-dose, crossover study of meclofenamate sodium in women with primary dysmenorrhea. Simultaneous evaluations of pain intensity and pain relief, sampling of continuous intrauterine pressure recording, and monitoring of blood meclofenamate levels were carried out. Improvements in pain intensity and pain relief were observed at 45 minutes and reached statistical significance at and beyond 1 hour 45 minutes after meclofenamate therapy. Ten of 14 uterine pressure parameters showed statistically significant responses after drug therapy and 12 of the 14 parameters showed statistically significant differences in time-response patterns. Statistically significant changes were noted as early as 45 minutes after meclofenamate therapy. Statistically significant correlations were found between and among the parameters of blood drug level and the subjective and objective measures. No drug-related adverse effects were found.

  16. Observation on the Effect of Acupoint Injection plus Massage Therapy on Primary Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    Lü Li-xia; Lü Meng; Fan Yi-wen

    2014-01-01

    Objective: To observe the clinical effects of acupoint injection therapy plus massage on primary dysmenorrhea (PD). Methods: Ninety patients with PD were randomly divided into a treatment group or a control group, 45 cases in each group. The treatment group was treated by injection of Vitamin K3into Sanyinjiao (SP 6) plus massage on Diji (SP 8). The control group was treated by oral administration of Ibuprofen sustained-release capsule. Before and after the treatment, visual analogue scale (VAS) was adopted to assess pain degree of the patients. The therapeutic effects were observed after continuous treatment of three cycles of menstruation. Results: After treatment, VAS scores were obviously decreased in both groups and the differences were statistically significant (allP Conclusion: Acupoint injection therapy plus massage for PD is effective and better than simple oral administration of Ibuprofen sustained-release capsule.

  17. Bian Zheng Lun Zhi as a Complementary and Alternative Treatment for Menstrual Cramps in Women with Dysmenorrhea: A Prospective Clinical Observation

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    Pin-Yi Lin

    2014-01-01

    Full Text Available Background. Limited scientific evidence supports the positive effects of traditional Chinese medicine (TCM for treating dysmenorrhea. Thus, an observation period of 3 months could verify the ancient indication that TCM treatments effectively alleviate menstrual cramps in women with primary dysmenorrhea or endometriosis. Methods. A prospective, nonrandomized study (primary dysmenorrhea and endometriosis groups was conducted in women with dysmenorrhea for more than three consecutive menstrual cycles. All patients received TCM prescriptions based on bian zheng lun zhi theory 14 days before menstruation for a period of 12 weeks. Pain intensity was evaluated using a 10-cm visual analogue scale and two validated questionnaires (the Menstrual Distress Questionnaire and the World Health Organization Quality of Life questionnaire. Results. Of the initial 70 intent-to-treat participants, the women with dysmenorrhea reported significant alleviation of cramps during menstruation after the 12-week TCM treatment. Mixed model analysis revealed that TCM prescriptions were more effective in alleviating fatigue, hot flashes, dizziness, painful breasts, excitement, and irritability in the primary dysmenorrhea group (N=36 than in the endometriosis group (N=34. Conclusion. TCM prescriptions based on syndrome differentiation theory might be a potentially viable choice for treating painful menstruation and premenstrual symptoms after ruling out endometriosis.

  18. [Dan'e-fukang soft extract for dysmenorrhea: a meta-analysis].

    Science.gov (United States)

    Yu, Kun; Zhang, Zhen-dong; Xiao, Zheng; Wei, Wei; Wang, Zheng-long

    2014-07-01

    To assess the efficacy and safety of Dan'e-fukang soft extract for dysmenorrhea by meta-analysis. Cochrane Controlled Trials Register, PubMed, EMBASE, CBM, VIP, Wanfang Data, and CNKI databases were searched. Results of randomized controlled trials were also harvested from pharmaceutical companies by manual search. Meta-analysis was carried out according to the method provided by the Cochrane Collaboration with RevMan5.0 software. Twelve Chinese papers were selected, and 1213 patients were included. Significant difference in recovery rate was found between Dan'e-fukang soft extract group and other drugs group (RR=1.33, 95%CI: 1.02-1.75, P0.05). No statistical difference was noticed in total effective rate between two groups (RR=1.04, 95%CI: 1.00-1.08, P>0.05). A statistical difference in improvement of dysmenorrhea symptoms was found before and after treatment in both Dan'e-fukang soft extract group and other drugs group (MD=5.79, 95%CI: 5.01-6.56, P0.05) and after treatment (MD=-0.94, 95%CI: -2.11-0.23, P>0.05). Oral administration of Dan'e-fukang soft extract caused only mild gastrointestinal discomfort, but other drugs had more adverse effects including serious gastrointestinal reaction, severe liver dysfunction, vaginal bleeding, and female masculinity. The existing evidence shows that Dan'e-fukang soft extract has the same efficacy as other drugs in treatment of dysmenorrheal. Because of the quality of the included studies was limited, the evidence of the efficacy and safety of Dan'e-fukang soft extract was not strong, and high-quality randomized trials with large samples are needed.

  19. EFFECT OF ACUPUNCTURE STIMULATION AT SANYINJIAO (SP 6) ON CEREBRAL GLUCOSE METABOLISM IN DYSMENORRHEA PATIENTS

    Institute of Scientific and Technical Information of China (English)

    GONG Ping; ZHANG Ming-min; JIANG Li-ming; WU Zhi-jian; WANG Wei; HUANG Guang-ying

    2006-01-01

    Objective: To study the central mechanism of acupuncture stimulation of Sanyinjiao ( 三阴交 SP6) in relieving dysmenorrhea. Methods: A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the first positron emission tomography (PET) scan examination, they were assigned to pseudoacupuncture group by using the acupuncture needle just to prick the skin of Sanyinjiao (SP 6); while on the second PET scans, they were assigned to acupuncture group by inserting the needle into the same acupoint.18F fluorodeoxyglucose (18F-FDG) PET of the whole brain was performed during pseudo-acupuncture and real acupuncture of Sanyinjiao (SP 6). The acquired PET data were analyzed by using statistical parametric mapping (SPM) software to determine changes of glucose metabolism in different cerebral regions. The patient's pain intensity was rated by using 0- 10 numerical pain intensity scale. Results: After pseudo-acupuncture stimulation of Sanyinjiao (SP 6), no significant changes were found in the pain intensity ( P >0.05), while after real-acupuncture stimulation, the pain intensity declined significantly (P < 0.01 ). Following acupuncture of the right Sanyinjiao (SP 6), multiple cerebral regions involving pain were activated (increase of glucose metabolism), including ipsilateral lenticular nucleus (globus pallidus, putamen), ipsilateral cerebellum and insular lobe, bilateral dorsal thalamus, ipsilateral paracentral lobule, bilateral amygdaloid bodies, contralateral substantia nigra of the midbrain, bilateral second somatosensory (S Ⅱ ) areas, ispsilateral hippocampal gyrus, frontal part of the ipsilateral cingulated gyrus, and bilateral mammary bodies of the hypothalamus. In addition, fewer regions of the cerebral cortex responded with decrease of the glucose metabolism after real acupuncture.

  20. Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea.

    Science.gov (United States)

    Akerlund, Mats

    2002-01-01

    Important sources of oxytocin and vasopressin in the human, apart from the supraoptic and paraventricular nuclei of the brain, may be the fetus during labor as well as the endometrium and decidua of the uterus itself. The release of oxytocin and vasopressin to plasma is under influence of ovarian steroids. The two hormones stimulate uterine contractions in pregnant and non-pregnant women via myometrial oxytocin and vasopressin V1a receptors. At the onset of human labor preterm or at term no clear rise in the maternal plasma concentration of oxytocin and/or vasopressin has been demonstrated, but there may be an increased pulse frequency of the release of oxytocin to plasma with the advance of labor. Vasopressin is more potent than oxytocin on isolated myometrium from women undergoing Cesarean section at term. The myometrial concentration of the two receptors is about equal. At the onset of labor preterm and at term there is a tendency to an increase in the density of oxytocin and vasopressin V1a receptors, but there may be a heterogeneous expression of at least the former receptor between different myometrial cells. In advanced labor or after oxytocin treatment the receptors are markedly downregulated. The importance of oxytocin and vasopressin in mechanisms of preterm labor is confirmed by the therapeutic effect in the condition of the oxytocin and vasopressin V1a receptor blocking oxytocin analogue, atosiban. In women with primary dysmenorrhea the plasma concentration of vasopressin is elevated. The in vivo effect of vasopressin on uterine activity in non-pregnant women is about five times more pronounced than that of oxytocin, and it increases premenstrually. Correspondingly, the density of vasopressin V1a and oxytocin receptors vary to the same degree, and a premenstrual rise in the former receptor is seen. Atosiban and the non-peptide compound, SR 49059, which binds to the two receptors in a similar way as atosiban, are therapeutically effective in dysmenorrhea.

  1. Specific physiological responses in women with severe primary dysmenorrhea during the menstrual cycle.

    Science.gov (United States)

    Park, Mi-Kyong; Watanuki, Shigeki

    2005-11-01

    This study examined the specific physiological responses of women with primary dysmenorrhea during the severely painful menstrual (days 1-2 of menstruation) and the non-painful follicular phases (days 5-8 after the onset of menstruation). Subjects consisted of 10 severe primary dysmenorrheic (Group P) and 10 non-dysmenorrheic women (Group C) with regular menstrual cycles. However, only 9 out of 10 and 8 out of 10 subjects of Groups P and C participated during the follicular phase. Physiological measures were taken in a resting state for 60 min. In the menstrual phase, the pain ratings and secretory immunoglobulin A (s-IgA) concentrations of Group P were significantly higher than those of Group C, with relatively significant decreases in the leg-skin temperature in the former as well. In addition, the systolic (SBP) and diastolic blood pressure (DBP) at 45 min after rest in Group P were significantly higher than those found in Group C. These reactions strongly suggest activation of the sympathetic-adrenal-medullary axis (SAM axis) by painful stress. Furthermore, the low-frequency (LF) component of the SBP variability (SBPV) was significantly higher in Group P than Group C, even during the follicular phase. These findings imply that Group P may well have elevated activities of the SAM axis throughout the whole menstrual cycle. As such, it suggests that dysmenorrheic women may be affected by certain stressors other than pain per se and pain-derived emotions throughout the whole menstrual cycle. The findings also indicate that women with dysmenorrhea have more sensitive responses to the SAM system than non-dysmenorrheic women during stress. Moreover, the high-frequency (HF) component of heart rate variability (HRV), or the index for the vagus nerve activity, displayed a consistently higher value in Group P than C. It is postulated that the human body may have responded to pain in an attempt to maintain the homeostatic state by enhancing vagus nerve activity.

  2. Altered Cytokine Gene Expression in Peripheral Blood Monocytes across the Menstrual Cycle in Primary Dysmenorrhea: A Case-Control Study

    Science.gov (United States)

    Ma, Hongyue; Hong, Min; Duan, Jinao; Liu, Pei; Fan, Xinsheng; Shang, Erxin; Su, Shulan; Guo, Jianming; Qian, Dawei; Tang, Yuping

    2013-01-01

    Primary dysmenorrhea is one of the most common gynecological complaints in young women, but potential peripheral immunologic features underlying this condition remain undefined. In this paper, we compared 84 common cytokine gene expression profiles of peripheral blood mononuclear cells (PBMCs) from six primary dysmenorrheic young women and three unaffected controls on the seventh day before (secretory phase), and the first (menstrual phase) and the fifth (regenerative phase) days of menstruation, using a real-time PCR array assay combined with pattern recognition and gene function annotation methods. Comparisons between dysmenorrhea and normal control groups identified 11 (nine increased and two decreased), 14 (five increased and nine decreased), and 15 (seven increased and eight decreased) genes with ≥2-fold difference in expression (Pmenstrual phase, genes encoding pro-inflammatory cytokines (IL1B, TNF, IL6, and IL8) were up-regulated, and genes encoding TGF-β superfamily members (BMP4, BMP6, GDF5, GDF11, LEFTY2, NODAL, and MSTN) were down-regulated. Functional annotation revealed an excessive inflammatory response and insufficient TGF-β superfamily member signals with anti-inflammatory consequences, which may directly contribute to menstrual pain. In the secretory and regenerative phases, increased expression of pro-inflammatory cytokines and decreased expression of growth factors were also observed. These factors may be involved in the regulation of decidualization, endometrium breakdown and repair, and indirectly exacerbate primary dysmenorrhea. This first study of cytokine gene expression profiles in PBMCs from young primary dysmenorrheic women demonstrates a shift in the balance between expression patterns of pro-inflammatory cytokines and TGF-β superfamily members across the whole menstrual cycle, underlying the peripheral immunologic features of primary dysmenorrhea. PMID:23390521

  3. Auricular Acupressure Combined with an Internet-Based Intervention or Alone for Primary Dysmenorrhea: A Control Study

    Directory of Open Access Journals (Sweden)

    Mei-Ling Yeh

    2013-01-01

    Full Text Available Background. Primary dysmenorrhea is prevalent in adolescents and young women. Menstrual pain and distress causes poor school performance and physiological damage. Auricular acupressure can be used to treat these symptoms, and Internet-based systems are a flexible way of communicating and delivering the relevant information. Objective. This study investigates the effects of auricular acupressure (AA alone and combined with an interactive Internet-based (II intervention for the management of menstrual pain and self-care of adolescents with primary dysmenorrhea. Design. This study adopts a pretest/posttest control research design with a convenience sample of 107 participants. Results. The outcomes were measured using the short-form McGill pain questionnaire (SF-MPQ, visual analogue scale (VAS, menstrual distress questionnaire (MDQ, and adolescent dysmenorrheic self-care scale (ADSCS. Significant differences were found in ADSCS scores between the groups, and in SF-MPQ, VAS, MDQ, and ADSCS scores for each group. Conclusion. Auricular acupressure alone and a combination of auricular acupressure and interactive Internet both reduced menstrual pain and distress for primary dysmenorrhea. Auricular acupressure combined with interactive Internet instruction is better than auricular acupuncture alone in improving self-care behaviors.

  4. Auricular Acupressure to Improve Menstrual Pain and Menstrual Distress and Heart Rate Variability for Primary Dysmenorrhea in Youth with Stress

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    Yu-Jen Wang

    2013-01-01

    Full Text Available Background. Dysmenorrhea and accompanying symptoms can have a negative impact on academic achievement, physical activity and functioning, and quality of life. Unfortunately, stress increases the sensitivity and severity of pain, activating sympathetic responses while inhibiting parasympathetic responses. Objective. This study used objective, physiological measurements to evaluate the effects of auricular acupressure on menstrual pain and menstrual distress in young college students with primary dysmenorrhea across two menstrual cycles. The aim was to determine if significant differences could be detected between the intervention and follow-up phases after controlling life stress. Design. A one-group experimental research design was used, and repeated measurements and followups were done. Thirty-two women completed questionnaires and physiological parameters were measured. Results. Significant differences between the intervention and follow-up phases were found for high frequency (HF and blood pressure on day 1 and no significant differences in menstrual pain and menstrual distress, heart rate variability, low frequency (LF, LF/HF ratio, or heart rate. Conclusion. Auricular acupressure effectively increases parasympathetic activity to maintain autonomic function homeostasis in young women with primary dysmenorrhea and may have a value in alleviating menstrual pain and menstrual distress in a high-stress life. Future studies should consider stress, stimulus dose of auricular acupressure, severity of menstrual pain, and a longitudinal research design.

  5. Comparison of the effect of ginger and zinc sulfate on primary dysmenorrhea: a placebo-controlled randomized trial.

    Science.gov (United States)

    Kashefi, Farzaneh; Khajehei, Marjan; Tabatabaeichehr, Mahbubeh; Alavinia, Mohammad; Asili, Javad

    2014-12-01

    Primary dysmenorrhea is common among young women and results in their incapacitation; it can be accompanied by various symptoms that can disrupt their lives. The aim of this randomized trial was to compare the effect of ginger, zinc sulfate, and placebo on the severity of primary dysmenorrhea in young women. One hundred and fifty high school students were recruited. The participants were divided into three groups. The first group received ginger capsules, the second group received zinc sulfate capsules, and the third group received placebo capsules. All participants took the medications for four days, from the day before the commencement of menstruation to the third day of their menstrual bleeding. The severity of dysmenorrhea was assessed every 24 hours by the pain visual analog scale. The severity of pain was significantly different between, before, and after the intervention in both the ginger and the zinc sulfate groups (p ginger and zinc sulfate reported more alleviation of pain during the intervention (p Ginger and zinc sulfate had similar positive effects on the improvement of primary dysmenorrheal pain in young women.

  6. Acupuncture or Acupressure at the Sanyinjiao (SP6 Acupoint for the Treatment of Primary Dysmenorrhea: A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Ma-Na Chen

    2013-01-01

    Full Text Available This meta-analysis aimed to evaluate the effectiveness of acupuncture or acupressure at the Sanyinjiao (SP6 acupoint in relieving pain associated with primary dysmenorrhea. We searched the scientific literature databases to identify randomized controlled trials. The primary outcome was visual analogue scale (VAS pain score. Three acupuncture and four acupressure trials were included in the meta-analyses. For the acupuncture analysis, there was no difference in the mean VAS score reduction between the SP6 acupoint and control (GB39 acupoint groups (−4.935; lower limit = −15.757, upper limit = 5.887; P=0.371. For the acupressure analysis, there was a significant difference in the mean VAS score after intervention between the SP6 acupoint and control (rest/light touch at SP6/nonacupoint acupressure groups, favoring the SP6 acupoint group (−1.011; lower limit = −1.622, upper limit = −0.400; P=0.001. Sensitivity analyses demonstrated good reliability of the meta-analyses findings. These findings suggest that acupuncture at SP6 is not more effective than acupuncture at an unrelated acupoint in the relief from primary dysmenorrhea. Acupressure at SP6 may be effective in the relief from primary dysmenorrhea. High-quality randomized controlled trials are needed to confirm these findings.

  7. [Study of effective components and molecular mechanism for Guizhi Fuling formula treatment of dysmenorrhea, pelvic inflammatory disease and uterine fibroids].

    Science.gov (United States)

    Ke, Zhi-peng; Zhang, Xin-zhuang; Ding, Yue; Cao, Ze-yu; Li, Na; Cao, Liang; Wang, Tuan-jie; Zhang, Chen-feng; Ding, Gang; Wang, Zhen-zhong; Xiao, Wei; Xu, Xiao-jie

    2015-03-01

    In this study, the active components and potential molecular .mechanism of Guizhi Fuling formula in treatment on dysmenorrhea, pelvic inflammation, and hysteromyoma were investigated using network pharmacological methods. Sterols and pentacyclic triterpenes, with high moleculal network degree, revealed promising effects on anti-inflammatory, analgesic, anti-tumor, and immune-regulation, according to D-T network analysis. On the other hand, the targets with high degree were involved in inflammatory, coagulation, angiopoiesis, smooth muscle contraction, and cell reproduction, which showed the novel function in anti-dysmenorrhea, pelvic inflammation, and hysteromyoma. Furthermore, the formula was indicated to play a key role in smooth muscle proliferation, inhibition of new vessels, circulation improvement, reduction of hormone secretion, alleviation of smooth muscle, block of arachidonic acid metabolism, and inflammation in uterus. Thus, the main mechanism of Guizhi Fuling formula was summarized. In conclusion, Guizhi Fuling formula was proven to alleviated dysmenorrhea, pelvic inflammation, and hysteromyoma by acting on multiple targets through several bioactive compounds, regulating 21 biological pathways.

  8. Comparative Study on the Analgesic Effects of Different Moxibustion Methods with Tai-yi Moxa Stick in Treating Primary Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    Wu Jiu-long; Wang Yu-fan; Zhang Jian-bin; Wang Ling-ling; Chen Hong-yu; Tang Yi-chun; Ma Xiao-yu; Huan Jia-hui; Chen Ruo-yang; Mo Hui; Xu Xiu-zhu; Shen Xiao-jing

    2014-01-01

    Objective: To compare the therapeutic effects of two different moxibustion methods both with tai-yi moxa stick in treating primary dysmenorrhea. Methods: Forty-three patients were randomized into two groups by the random number table according to their treatment orders. The causalgic group was intervened by causalgic stimulation with tai-yi moxa stick while the tepid group was treated by mild thermal stimulation with tai-yi moxa stick. Shiqizhui (EX-B 8) was selected for both groups. Visual analogue scale (VAS) was used for observation before and during the treatment by every 10 min to compare the clinical efficacies between the two groups. Results: Before treatment, there was no statistically significant difference in pain intensity between the two groups (P>0.05). After treatment, both groups achieved significant improvements in pain intensity (P0.05), but the difference was enlarged comparing with that before treatment. The pain relief during the first 10 min of treatment was slower in the causalgic group than that in the tepid group. However, during the later 20 min, the pain relief in the calsalgia group gradually outpaced that in the tepid group. Conclusion: The two moxibustion methods with tai-yi moxa stick both have a good instant analgesic effect in treating primary dysmenorrhea. For patients with primary dysmenorrhea, if 30 min is regarded as the treatment time, mild stimulation was suggested to be used for the first 10 min, and causalgic stimulation for the later 20 min to achieve a better curative effect.

  9. Research Progress on the Mechanism of Acupuncture Treatment of Primary Dysmenorrhea%针灸治疗原发性痛经的机理研究述评

    Institute of Scientific and Technical Information of China (English)

    王秀芳; 李居怡; 邓柏颖

    2013-01-01

    Objective:To explore the mechanism of acupuncture treatment of primary dysmenorrhea. Methods:Through the collection of nearly 20 A on acupuncture treatment of primary dysmenorrhea mechanism of relevant literature and summarize. Results: The acupuncture in patients with primary dysmenorrhea in regulating immune function,scavenging free radical damage,regulation of neuroendocrine function, improve blood rheology, better treatment effect of trace elements. Conclusion: Acupuncture has a good effect in the treatment of primary dysmenorrhea, to study the mechanism provides reliable clues for acupuncture treatment of primary dysmenorrhea.%目的:探讨针灸治疗原发性痛经的作用机理.方法:通过搜集近20 a有关针灸治疗原发性痛经机理的相关文献并进行归纳整理.结果:针灸对于原发性痛经患者在调节免疫功能、清除自由基损伤、调节神经内分泌功能、改善血液流变性、微量元素等方面取得了较好的疗效.结论:针灸在原发性痛经治疗中取得了很好的疗效,其机理的研究为针灸治疗原发性痛经提供了可靠的线索.

  10. Clinical application of Baliao acupoint in the treatment of dysmenorrhea%八髎穴治疗痛经的临床应用概述

    Institute of Scientific and Technical Information of China (English)

    陈莹; 高微; 郑培

    2015-01-01

    The Baliao acupoint originates from Huangdi Neijing, through which good effects has been obtained in the treatment of dysmenorrhea in recent years. The paper explores some related clinical research data that the Baliao acupoint used in treating dysmenorrhea. The results indicate that it can acquire good curative effects about treating dysmenorrhea by massage, acupuncture, moxibustion, acupoint injection, embedded wire and other treatments in the Baliao acupoint. The paper summarizes the experience of Baliao acupoint to treat dysmenorrhea, providing powerful evidence for the clinical treatment of dysmenorrhea by Baliao acupoint.%八髎穴最早出自于《黄帝内经》,近年来在痛经的治疗中取得较好疗效。就八髎穴治疗痛经的临床研究资料进行整理,发现通过在八髎穴运用推拿、针刺、艾灸、穴位注射、埋线等治法,治疗女子痛经取得较好的疗效。总结回顾了八髎穴治疗痛经的经验,为临床运用八髎穴治疗痛经提供有力证据。

  11. Differences in the Tongue Features of Primary Dysmenorrhea Patients and Controls over a Normal Menstrual Cycle

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    Jihye Kim

    2017-01-01

    Full Text Available Background. The aims of this study were to investigate the relationships between tongue features and the existence of menstrual pain and to provide basic information regarding the changes in tongue features during a menstrual cycle. Methods. This study was conducted at the Kyung Hee University Medical Center. Forty-eight eligible participants aged 20 to 29 years were enrolled and assigned to two groups according to their visual analogue scale (VAS scores. Group A included 24 females suffering from primary dysmenorrhea (PD caused by qi stagnation and blood stasis syndrome with VAS ≥ 4. In contrast, Group B included 24 females with few premenstrual symptoms and VAS < 4. All participants completed four visits (menses-follicular-luteal-menses phases, and the tongue images were taken by using a computerized tongue image analysis system (CTIS. Results. The results revealed that the tongue coating color value and the tongue coating thickness in the PD group during the menstrual phase were significantly lower than those of the control group (P=0.031 and P=0.029, resp.. Conclusions. These results suggest that the tongue features obtained from the CTIS may serve as a supplementary means for the differentiation of syndromes and the evaluation of therapeutic effect and prognosis in PD. Trial Registration. This trial was registered with Clinical Research Information Service, registration number KCT0001604, registered on 27 August 2015.

  12. In-office endometrial ablation using a third-generation uterine balloon therapy system: 12-month prospective follow-up on menstrual patterns and dysmenorrhea impact.

    Science.gov (United States)

    Chapa, Hector O; Venegas, Gonzalo; Antonetti, Alfred G; Van Duyne, Charles P; Sandate, Jeffrey; Bakker, Ken

    2009-01-01

    To evaluate the efficiency of in-office Thermachoice III (Ethicon, Somerville, New Jersey) endometrial ablations in resolving menstrual abnormalities as well as dysmenorrhea at 12 months after the procedure. This was a prospective, single arm, cohort study of women from an inner city, community based, physician group medical/ surgical clinic. Diagnostic hysteroscopy, dilation and curettage, and Thermachoice III endometrial ablation were performed under local analgesia. At baseline, N = 148. At 12 months, 23 patients were lost to follow-up, leaving 125 for the evaluable cohort. The largest resulting patient category was amenorrhea, with 66.4% (83 of 125 evaluable), followed by hypomenorrhea at 31% (39 of 125 evaluable). Three patients (2.4%) were considered clinical failures. These 3 patients initially were designated as having hypomenorrhea at 3 months. Dysmenorrhea reduction was statistically significant (p office Thermachoice III was observed, with high amenorrhea rates as well as persistently decreased dysmenorrhea.

  13. Effect of Homeopathy on Pain Intensity and Quality Of Life of Students With Primary Dysmenorrhea: A Randomized Controlled Trial

    Science.gov (United States)

    Alizadeh Charandabi, Sakineh Mohammad; Biglu, Mohammad Hossein; Yousefi Rad, Khatereh

    2016-01-01

    Background Observational studies indicate a positive association between homeopathy and pain relief and quality of life improvement in women with dysmenorrhea. However, there are no interventional studies in this area. Objectives To evaluate an association between homeopathy and pain relief and quality of life improvement in a double-blind placebo-controlled randomized trial with 2 parallel arms. Methods Fifty-four students with primary dysmenorrhea residing at the dormitories of the Tabriz University of Medical Sciences, Iran, who had moderate or severe menstrual pain, were randomized to receive either homeopathic remedy or placebo. The homeopath and participants were blinded to treatment assignment. Primary outcomes were pain intensity and quality of life assessed using a 10-cm visual analog scale and short-form 36 (SF-36), respectively, and the secondary outcome was number of analgesic pills used. Results Each group comprised 27 students; eventually, 26 in the homeopathic and 21 in the placebo group were followed up. There was no significant difference between the groups for either pain intensity (adjusted difference: -0.44; 95% CI: -1.43 to 0.54) or any other outcomes. Compared with the baseline scores, statistically significant improvements were observed in pain intensity (P = 0.021) and physical health (P = 0.020) scores only in the homeopathic group; and in the mental health score in both groups (P = 0.014 in the homeopathy group and P = 0.010 in the placebo group). Conclusions This study could not show any significant effect of homeopathy on primary dysmenorrhea in comparison with placebo. Considering the possible effect of the homeopath and the homeopathic remedies prescribed on the results of such interventions, further studies are needed to help us arrive at a conclusion. PMID:28144456

  14. Effects of Gyejibongnyeong-hwan on dysmenorrhea caused by blood stagnation: study protocol for a randomized controlled trial

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    Park Jeong-Su

    2012-01-01

    Full Text Available Abstract Background Gyejibongnyeong-hwan (GJBNH is one of the most popular Korean medicine formulas for menstrual pain of dysmenorrhea. The concept of blood stagnation in Korean medicine is considered the main factor of causing abdominal pain, or cramps, during menstrual periods. To treat the symptoms, GJBNH is used to fluidify the stagnated blood and induce the blood flow to be smooth, reducing pain as the result. The purpose of this trial is to identify the efficacy of GJBNH in dysmenorrhea caused by blood stagnation. Methods This study is a multi-centre, randomised, double-blind, controlled trial with two parallel arms: the group taking GJBNH and the group taking placebo. 100 patients (women from age 18 to 35 will be enrolled to the trial. Through randomization 50 patients will be in experiment arm, and the other 50 patients will be in control arm. At the second visit (baseline, all participants who were already screened that they fulfil both the inclusion and the exclusion criteria will be randomised into two groups. Each group will take the intervention three times per day during two menstrual cycles. After the treatment for two cycles, each patient will be followed up during their 3rd, 4th and 5th menstrual cycles. From the screening (Visit 1 through the second follow-up (Visit 6 the entire process will take 25 weeks. Discussion This trial will provide evidence for the effectiveness of GJBNH in treating periodical pain due to dysmenorrhea that is caused by blood stagnation. The primary outcome between the two groups will be measured by changes in the Visual Analogue Score (VAS of pain. The secondary outcome will be measured by the Blood Stagnation Scale, the Short-form McGill questionnaire and the COX menstrual symptom scale. Analysis of covariance (ANCOVA and repeated measured ANOVA will be used to analyze the data analysis. Trial registration Current Controlled Trials: ISRCTN30426947

  15. Effect of Zingiber officinale R. rhizomes (ginger on pain relief in primary dysmenorrhea: a placebo randomized trial

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    Rahnama Parvin

    2012-07-01

    Full Text Available Abstract Background Zingiber officinale R. rhizome (ginger is a popular spice that has traditionally been used to combat the effects of various inflammatory diseases. The aim of this study was to evaluate the effects of ginger on pain relief in primary dysmenorrhea. Method This was a randomized, controlled trial. The study was based on a sample of one hundred and twenty students with moderate or severe primary dysmenorrhea. The students were all residents of the dormitories of Shahed University. They were randomly assigned into two equal groups, one for ginger and the other for placebo in two different treatment protocols with monthly intervals. The ginger and placebo groups in both protocols received 500 mg capsules of ginger root powder or placebo three times a day. In the first protocol ginger and placebo were given two days before the onset of the menstrual period and continued through the first three days of the menstrual period. In the second protocol ginger and placebo were given only for the first three days of the menstrual period. Severity of pain was determined by a verbal multidimensional scoring system and a visual analogue scale. Results There was no difference in the baseline characteristics of the two groups (placebo n = 46, ginger n = 56. The results of this study showed that there were significant differences in the severity of pain between ginger and placebo groups for protocol one (P = 0.015 and protocol two (P = 0.029. There was also significant difference in duration of pain between the two groups for protocol one (P = 0.017 but not for protocol two (P = 0.210. Conclusion Treatment of primary dysmenorrhea in students with ginger for 5 days had a statistically significant effect on relieving intensity and duration of pain. Trial registration IRCT201105266206N3

  16. Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea

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    Jin, Lingmin; Yang, Xuejuan; Liu, Peng; Sun, Jinbo; Chen, Fei; Xu, Ziliang; Qin, Wei; Tian, Jie

    2017-01-01

    Purpose This study aimed to investigate the regional spontaneous brain activity changes in primary dysmenorrhea (PD) patients in different phases of the menstrual cycle by regional homogeneity (ReHo) analysis. Patients and methods Thirty-three PD patients and 32 healthy controls (HCs) separately received resting-state functional magnetic resonance imaging during menstrual phase and follicular phase (non-menstrual phase). Cox retrospective symptom scale (RSS), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were applied to assess related symptoms and emotions. Results There was no significant difference between the two groups in demographic data. The PD patients obtained higher RSS score, SAS score and SDS score than HCs. Compared with HCs, the ReHo values of the PD patients were increased in left midbrain and hippocampus, right posterior cingulate cortex (PCC), insula and middle temporal cortex (MTC) and decreased in left dorsolateral prefrontal cortex and right medial prefrontal cortex (mPFC) in menstrual phase. In non-menstrual phase, enhanced ReHo values were found in bilateral S1 and precuneus, left S2 and MTC, and reduced ReHo values were observed in left mPFC and orbital frontal cortex. RSS score positively correlated with ReHo values of midbrain and negatively correlated with mPFC and PCC. Conclusion Our results suggested that PD is accompanied by dynamic regional spontaneous activity changes across the menstrual cycle, and the altered regions were involved in descending pain modulation, default mode network and sensory modulation. These abnormal activations might contribute to maintain the menstrual pain.

  17. Premenstrual syndrome and dysmenorrhea: urban-rural and multiethnic differences in perception, impacts, and treatment seeking.

    Science.gov (United States)

    Wong, Li Ping

    2011-10-01

    Attitudes toward menarche and menstruation are largely influenced by sociological, cultural, and family environmental factors. Recognizing the influential effects that these factors might have on shaping adolescents' attitudes is crucial in designing a more effective means of transmitting health information. This study aimed to gather an in-depth understanding of perceptions, impacts, and treatment seeking on menstruation-related issues from an ethnically mixed group of rural and urban girls. In total, 27 focus group discussions (172 participants) were conducted between November 2008 and April 2009. Participants were adolescent girls aged 13-19 years, recruited from 7 public secondary schools in the Federal Territory of Kuala Lumpur and 4 public secondary schools from the rural districts of Kelantan, in Malaysia. Many participants revealed that they were not given or had not received detailed information about the mechanism or physiology of menstruation prior to its onset. Thus, many described the onset of menarche as shocking, an event for which they were unprepared, and which has had a tremendous impact on their emotions. More positive acceptance of menarche was reported in the urban than with the rural groups. Despite the high prevalence of premenstrual syndrome and dysmenorrhea, participants across urban-rural and ethnic groups perceived the problems as completely normal, hence they relied on self-care methods and did not want to seek professional treatment. More rural girls compared to urban girls were embarrassed to talk to their mothers or consult their physicians regarding menstruation-related problems. Menstruation-related education would have a positive impact in improving adolescent girls' knowledge and in nurturing a positive attitude toward menstruation-related matters at home, at school, and in the community. Copyright © 2011 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  18. The treatment experience about primary dysmenorrhea%治疗原发性痛经经验谈

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    胥风华; 张晓爽; 韩亚光

    2015-01-01

    Dysmenorrhea is a common clinical disease,it is interfering many women;Serious affect the women's health and the quality of life. The treatment of it,everyone has his own point of view. Professor Yanhua Han is the main fourth descendant of the Hanshi gynaecology ,she is also a guidance teacher of the fifth group famous Chinese Medicine expert academic experience inheritance work with rich experience. She treats primary dysmenorrhea with "Wenbaoyin painkillers"add and subtract, And according to the severity of the disease, in the period uses proprietary Chinese Medicine or liquid form,and the clinical effect is satisfied.%痛经是临床上常见的一种疾病,一直困扰很多女性,严重影响了女性健康及生活质量.对其的治疗,各大家均有所长.韩延华教授是韩氏妇科的第四代主要传人,第五批全国名老中医药专家学术经验继承工作指导教师,学验俱丰.她治疗原发性痛经多采用自拟方"温胞止痛饮"加减治疗,并根据病情的严重程度,在非经期使用成药或汤药治疗,临床效果满意.

  19. The Correlation of Students Knowledge Level About Menstrual with Dysmenorrhea Handling Effort on Classes XII Students At SMA Negeri 1 Parongpong

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    Drs. Oktoruddin Harun

    2015-08-01

    Full Text Available Background reproductive health is a problem that most important to get attention especially among teenagers an effort to get to the healthy have to start at least in the early adolescence because teenagers to be prepared either knowledge attitude or the act of which reached at reproduction healthy. An incident the occurrence of the average dysmenorrhea in young women between 168 81. Some of them are yet resulted in heavy dysmenorrhea so as to interrupt activities such as not going to school. The purpose of this research is to knowledge of menstruation relations with dysmenorrhea handling effort on classes XII students at SMA Negeri 1 Parongpong. The method is applicable study analitik with a method of approach cross-sectional. The total sample 62 students classes XII with been gained through total sampling data collection techniques directly from respondents with the methods in the form of a questionnaire. The results of this research is 62 student on classes XII at SMA Negeri 1 Parongpong having a lack of knowledge of the menses that is some 20 323 students and the level of knowledge have enough that is some 25 403 students while the level of knowledge have good that is some 17 274 students. In efforts to handle dysmenorrhea so that the level of handling pain diminished that is some 33 532 students and with the level of handling so that pain increase that is some 29 468 students.

  20. Efficacy and safety of a flexible extended regimen of ethinylestradiol/drospirenone for the treatment of dysmenorrhea: a multicenter, randomized, open-label, active-controlled study.

    Science.gov (United States)

    Momoeda, Mikio; Kondo, Masami; Elliesen, Joerg; Yasuda, Masanobu; Yamamoto, Shigetomo; Harada, Tasuku

    2017-01-01

    Dysmenorrhea is a common condition in women, which is characterized by menstrual pain. Low-dose estrogen/progestin combined oral contraceptives have been shown to reduce the severity of dysmenorrhea symptoms, and a 28-day cyclic regimen of ethinylestradiol/drospirenone (28d regimen) is approved for this indication in Japan. The aim of this study was to assess the safety and efficacy of a flexible extended regimen of ethinylestradiol/drospirenone (flexible regimen) in Japanese women with dysmenorrhea. This multicenter, open-label study was performed in Japanese women with dysmenorrhea who, after a baseline observational phase, were randomized to receive ethinylestradiol 20 μg/drospirenone 3 mg in a flexible regimen (one tablet each day for 24-120 days followed by a 4-day tablet-free interval) or in the standard 28d regimen (one tablet each day for 24 days, followed by 4 days of placebo tablets for six cycles). The primary endpoint was the number of days with dysmenorrhea of at least mild intensity over a 140-day evaluation period. Dysmenorrhea scores, bleeding patterns, and other pain-related parameters were also assessed. A total of 216 women (mean age 29.7 years) were randomized to the flexible regimen (n=108) or 28d regimen (n=108) and 212 were included in the full analysis sets (flexible regimen, n=105; 28d regimen, n=107). Women in the flexible-regimen group reported a mean of 3.4 fewer days with dysmenorrheic pain than women in the 28d-regimen group, with similar decreases in disease severity reported in both treatment groups. According to the investigators, 64.8% and 59.4% of women in the flexible-regimen and 28d-regimen treatment groups had "very much improved" or "much improved" disease, while 54.3% and 50.9% of patients reported being "very much satisfied" or "much satisfied" with their treatment, respectively. In Japanese women with dysmenorrhea, a flexible extended regimen of ethinylestradiol/drospirenone decreased the number of days with dysmenorrheic

  1. Effect of Dill (Anethum graveolens on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial

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    Reza Heidarifar

    2014-01-01

    Full Text Available Background: Dysmenorrhea has negative effects on women′s life. Due to side-effects of chemical drugs, there is growing trend toward herbal medicine. The aim of this study was to assess the effect of Dill compared to mefenamic acid on primary dysmenorrhea. Materials and Methods: This double-blind, randomized, clinical trial study was conducted on 75 single female students between 18 and 28 years old educating in Nursing and Midwifery School and Paramedical Faculty of Qom University of Medical Sciences of Iran in 2011. They were allocated randomly into one of the three groups: In Dill group, they took 1000 mg of Dill powder q12h for 5 days from 2 days before the beginning of menstruation for two cycles. Other groups received 250 mg mefenamic acid or 500 mg starch capsule as placebo, respectively. Dysmenorrhea severity was determined by a verbal multidimensional scoring system and a visual analog scale (VAS. Students with mild dysmenorrhea were excluded. Data were analyzed by SPSS using the descriptive statistic, paired-samples t-test, Wilcoxon signed-rank test, Mann-Whitney test, and Kruskal-Wallis test. Results: There were no significant differences between three groups for demographic or descriptive variables. Comprising the VAS showed that the participants of Dill and mefenamic acid groups had lower significant pain in the 1 st and the 2 nd months after treatment, whereas in the placebo group this was only significant in the 2 nd month (P < 0.05. Conclusion: Dill was as effective as mefenamic acid in reducing the pain severity in primary dysmenorrhea. Further studies regarding side-effects of Dill and its interactivity are recommended.

  2. Comparing Menarche Age, Menstrual Regularity, Dysmenorrhea and Analgesic Consumption among Athletic and Non-athletic Female Students at Universities of Tabriz-Iran

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    Hasan Matin Homai

    2014-07-01

    Full Text Available Objectives: Although sport has many advantages, it sometimes causes disorders on women’s menstrual cycles. One of these can be delaying the menarche age and creating disorder in the menstrual cycle. On the other hand, sport is effective on dysmenorrhea and the pain resulted from it. This research aims at comparing the menarche age, menstrual regularity, dysmenorrhea and analgesic consumption among athletic and non-athletic students at the universities of Tabriz. Materials and Methods: This study is a causal comparative one which was done in 2010 on 360 girl students in 18-28 years old majoring in medicine and non-medicine at the universities of Tabriz. Samples were chosen selectively and completed the questionnaires, visual analogue scale (VAS, sport and menstrual record. The data were analyzed by SPSS 16 statistical software via descriptive and inferential statistical tests (Mann-Whitney U and Chi-square. P<0.05 was considered as significant. Results: In studying data, menarche age (P=0.001 and menstrual disorder (P=0.026 had significant difference which was higher in athletic group. The frequency of dysmenorrhea in athletic and non-athletic group did not have significant statistical difference (P=0.39 while the analgesic consumption was significantly lower in the athletic group (P=0.001. Conclusion: This study showed that sport can improve dysmenorrhea and decrease the need for analgesic for improving the dysmenorrhea among the people. Meanwhile, it is necessary to pay more attention to nutrition which is one of the important reasons of delayed menarche and menstrual disorder.

  3. Moxibustion for pain relief in patients with primary dysmenorrhea: A randomized controlled trial

    Science.gov (United States)

    Bo, Linna; Lao, Lixing; Chen, Jiao; Yu, Siyi; Yu, Zheng; Tang, Hongzhi; Yi, Ling; Wu, Xi; Yang, Jie; Liang, Fanrong

    2017-01-01

    Background Though moxibustion is frequently used to treat primary dysmenorrhea in China, relevant evidence supporting its effectiveness is still scanty. Methods This study was a pragmatic randomized, conventional drug controlled, open-labeled clinical trial. After initial screen, 152 eligible participants were averagely randomized to receive two different treatment strategies: Moxibustion and conventional drugs. Participants and practitioners were not blinded in this study. The duration of each treatment was 3 months. The primary outcome was pain relief measured by the Visual Analogue Scale. The menstrual pain severity was recorded in a menstrual pain diary. Results 152 eligible patients were included but only 133 of them eventually completed the whole treatment course. The results showed that the menstrual pain intensity in experimental group and control group was reduced from 6.38±1.28 and 6.41±1.29, respectively, at baseline, to 2.54±1.41 and 2.47±1.29 after treatment. The pain reduction was not significantly different between these two groups (P = 0.76), however; the pain intensity was significantly reduced relative to baseline for each group (P<0.01). Three months after treatment, the effectiveness of moxibustion sustained and started to be superior to the drug’s effect (-0.87, 95%CI -1.32 to -0.42, P<0.01). Secondary outcome analyses showed that moxibustion was as effective as drugs in alleviating menstrual pain-related symptoms. The serum levels of pain mediators, such as PGF2α, OT, vWF, β-EP, PGE2, were significantly improved after treatment in both groups (P<0.05). No adverse events were reported in this trial. Conclusions Both moxibustion and conventional drug showed desirable merits in managing menstrual pain, given their treatment effects and economic costs. This study as a pragmatic trial only demonstrates the effectiveness, not the efficacy, of moxibustion for menstrual pain. It can’t rule out the effect of psychological factors during

  4. Comparison of the effect of acupressure at spleen 6 and liver 3 points on the anxiety level of patients with primary dysmenorrhea- Blind randomized controlled clinical trial

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    Mahboobeh Kafaei Atrian

    2014-08-01

    Full Text Available Background: Anxiety is a factor that is associated with dysmenorrhea. The purpose of this study was to compare the effect of acupressure at spleen 6 and liver 3 points on the anxiety level of patients with primary dysmenorrhea. Methods: In this randomized clinical trial study, acupressure was applied on spleen 6 and liver 3 points. Sixty seven students were evaluated in three menstrual periods. They were assigned to groups using a randomized block design with allocation ratio of 1:1 based on the severity of pain. Spielberger state-trait anxiety inventory (STAI and visual analogue scale for pain intensity were used. Analysis was performed by SPSS-16 software using chi-square, t-test, Mann–Whitney, paired sample t-test and covariance analysis. Results: In liver 3 and spleen 6 groups, 11 and 17 students were studied, respectively. The mean ±SD values of apparent anxiety before and after intervention for liver 3 group were 45.100±9.769 and 38.100±10.608 and for spleen 6 group were 46.823±12.248 and 44.352±11.942, respectively. Reduction of apparent anxiety was only significant in the liver 3 group (p0.05 in both groups. There was no difference between groups before and after intervention (p>0.05. Conclusion: Since pressure on liver 3 point reduced apparent anxiety, pressure on liver 3 point is recommended in patients with dysmenorrhea.

  5. Primary dysmenorrhea magnitude, associated risk factors, and its effect on academic performance: evidence from female university students in Ethiopia

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    Hailemeskel S

    2016-09-01

    Full Text Available Solomon Hailemeskel,1 Asrate Demissie,2 Nigussie Assefa3 1Department of Midwifery, College of Health Science, Institute of Medicine and Health Science, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Nursing and Midwifery, School of Allied Health Science, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Reproductive Health and Health Service Management, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Background: Primary dysmenorrhea (PD is the most common gynecologic compliant among adolescent females. There is a wide variation in the estimate of PD, which ranges from 50% to 90%, and the disorder is the most common cause of work and school absenteeism in adolescent females.Objective: To assess the prevalence and associated risk factors of PD among female university students and understand its effects on students’ academic performance.Methods: A cross-sectional study was employed in 440 research participants. A multistage stratified sampling technique was employed to select the study units. Structured and pretested self-administered questionnaires were used and weight and height measurements were conducted. The severity of dysmenorrheal pain was assessed by using a verbal multidimensional scoring system and visual analog scale. The data were double entered in Epi Info version 3.1 and analyzed using SPSS version 17. Descriptive statistics, chi-square test, and logistic regression analysis were performed.Results: A total of 440 students participated in this study. The prevalence of PD was 368 (85.4%. Of these, 123 (28.5% had mild, 164 (38.1% moderate, and 81 (18.8% severe primary dysmenorrheal pain. Among students with PD, 88.3% reported that PD had a negative effect on their academic performance. Of these, 80% reported school absence, 66.8% reported loss of class concentration, 56.3% reported class absence, 47.4% reported loss of class

  6. Primary dysmenorrhea magnitude, associated risk factors, and its effect on academic performance: evidence from female university students in Ethiopia

    Science.gov (United States)

    Hailemeskel, Solomon; Demissie, Asrate; Assefa, Nigussie

    2016-01-01

    Background Primary dysmenorrhea (PD) is the most common gynecologic compliant among adolescent females. There is a wide variation in the estimate of PD, which ranges from 50% to 90%, and the disorder is the most common cause of work and school absenteeism in adolescent females. Objective To assess the prevalence and associated risk factors of PD among female university students and understand its effects on students’ academic performance. Methods A cross-sectional study was employed in 440 research participants. A multistage stratified sampling technique was employed to select the study units. Structured and pretested self-administered questionnaires were used and weight and height measurements were conducted. The severity of dysmenorrheal pain was assessed by using a verbal multidimensional scoring system and visual analog scale. The data were double entered in Epi Info version 3.1 and analyzed using SPSS version 17. Descriptive statistics, chi-square test, and logistic regression analysis were performed. Results A total of 440 students participated in this study. The prevalence of PD was 368 (85.4%). Of these, 123 (28.5%) had mild, 164 (38.1%) moderate, and 81 (18.8%) severe primary dysmenorrheal pain. Among students with PD, 88.3% reported that PD had a negative effect on their academic performance. Of these, 80% reported school absence, 66.8% reported loss of class concentration, 56.3% reported class absence, 47.4% reported loss of class participation, 37.8% reported limited sport participation, 31.7% reported limitation in going out with friends, and 21% reported inability to do homework. Based on the multivariate logistic regression, PD was statistically significant with those who had lower monthly stipends, a history of attempt to lose weight, a history of depression or anxiety, disruption of social network of family, friends or people they love, who consumed more than four glasses of tea per day, who drunk one or more Coca-Cola or Pepsi per day, in

  7. Ge-Gen Decoction attenuates oxytocin-induced uterine contraction and writhing response: potential application in primary dysmenorrhea therapy.

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    Yang, Lu; Chai, Cheng-Zhi; Yue, Xin-Yi; Yan, Yan; Kou, Jun-Ping; Cao, Zheng-Yu; Yu, Bo-Yang

    2016-02-01

    The uterine tetanic contraction and uterine artery blood flow reduction are possible reasons for primary dysmenorrhea (PD). In the present study, we aimed to evaluate the uterine relaxant effect and the influence on uterine artery blood velocity of Ge-Gen Decoction (GGD), a well-known Chinese herbal formula. In female ICR mice, uterine contraction was induced by oxytocin exposure following estradiol benzoate pretreatment, and the uterine artery blood velocity was detected by Doppler ultrasound. Histopathological examination of the uterine tissue samples were performed by H&E staining. Ex vivo studies demonstrated that oxytocin, posterior pituitary, or acetylcholine induced contractions in isolated mouse uterus. GGD inhibited both spontaneous and stimulated contractions. In vivo study demonstrated that GGD significantly reduced oxytocin-induced writhing responses with a maximal inhibition of 87%. Further study demonstrated that GGD normalized oxytocin-induced abnormalities of prostaglandins F2 alpha (PGF2α) and Ca(2+) in mice. In addition, injection of oxytocin induced a decrease in uterine artery blood flow velocity. Pretreatment with GGD reversed the oxytocin response on blood flow velocity. Histopathological examination showed pretreatment with GGD alleviated inflammation and edema in the uterus when compared with the model group. Both ex vivo and in vivo results indicated that GGD possessed a significant spasmolytic effect on uterine tetanic contraction as well as improvement on uterine artery blood velocity which may involve PGF2α and Ca(2+) signaling, suggesting that GGD may have a clinic potential in PD therapy.

  8. Does the presence of coexisting diseases modulate the effectiveness of a low-dose estrogen/progestin, ethinylestradiol/drospirenone combination tablet in dysmenorrhea? Reanalysis of two randomized studies in Japanese women

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    Momoeda M

    2014-12-01

    Full Text Available Mikio Momoeda,1 Masakane Hayakawa,2 Yukio Shimazaki,3 Hideki Mizunuma,4 Yuji Taketani5 1Department of Integrated Women's Health, St Luke's International Hospital, Tokyo, 2Medical Affairs, 3Product Development, Bayer Yakuhin, Ltd, Osaka, 4Department of Obstetrics and Gynecology, Faculty of Medicine, Hirosaki University, Hirosaki, 5Japan Labour Health and Welfare Organization, Kawasaki, JapanBackground: The purpose of this study was to investigate the effectiveness of a combination of ethinylestradiol (EE and 0.02 mg/drospirenone (DRSP 3 mg in Japanese women with dysmenorrhea and in particular to determine whether or not the presence of specific coexisting organic diseases (eg, endometriosis, uterine fibroids, uterine adenomyosis has an impact on treatment.Methods and results: Four hundred and ten patients with dysmenorrhea aged 20 years or older (315 without coexisting organic disease, 28 with endometriosis, 37 with uterine fibroids, and 46 with uterine adenomyosis [some patients had multiple coexisting organic diseases] were enrolled and treated with EE/DRSP in either a 16-week comparator study or a 52-week long-term safety study. Evaluations included changes in total dysmenorrhea score, visual analog scale for dysmenorrhea, severity of symptoms, hormone levels, endometrial thickness, and safety outcomes. In both studies, the total dysmenorrhea score was significantly (P<0.001 decreased from baseline during treatment with EE/DRSP. Time-dependent changes in visual analog score for dysmenorrhea and alleviation of symptoms, such as lower abdominal pain, low back pain (lumbago, headache, and nausea/vomiting, were similar in all patient groups with and without any specific coexisting organic diseases. These improvements with EE/DRSP were observed for both short-term (16 weeks and long-term (52 weeks use. These effects were associated with suppressed increases in serum estradiol and progesterone levels and decreased endometrial thickness. The safety

  9. COMPARISON OF EFFECTS OF MASSAGE THERAPY ALONE AND IN COMBINATION WITH GREEN COCONUT WATER THERAPY ON Β-ENDORPHIN LEVEL IN TEENAGE GIRLS WITH DYSMENORRHEA

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    Fitria Hikmatul Ulya

    2017-08-01

    Full Text Available Background: Dysmenorrhea is pain during menstruation in lower abdomen, and is not due to other diseases. Effleurage massage and consuming green coconut water are considered able to reduce menstrual pain. However, little is known about the effect of the combination between the two interventions. Objective: To compare the effectiveness of effleurage massage and in combination with green coconut water on pain, anxiety, and ß-endorphin level in teenage girls with menstrual pain (dysmenorrhea. Design: A quasy experiment with pretest-posttest approach design with control group. There were 36 samples recruited in this study by purposive sampling, which were divided into a massage therapy group, the combination therapy group, and a control group. Menstrual pain was measured using Numeric Rating Scale, while anxiety was measured using Zung Self rating Anxiety Scale (ZSAS, and endorphin level using ELISA (Enzyme-Linked Immunosorbent Assay. One way anova test and repeated anova were performed as a bivariate analysis. Mancova and post hoc anova were used for multivariate analysis. Result: The combination of massage and green coconut water was more effective in reducing pain (p 0.013 and anxiety levels (p 0.000, and in increasing β-endorphin (p 0.029 with significant value of <0.05 compared to the massage therapy alone. Conclusion: The combination of effleurage massage and green coconut water had significant effect in decreasing anxiety and pain levels, and increasing β-endorphin levels in teenage girls with painful periods (dysmenorrhea; and more effective than performing effleurage massage only. It is suggested that this combination therapy could be used as an alternative therapy for women with dysmenrrohea.

  10. The Pathophysiology of Dysmenorrhea in Adenomyosis%子宫腺肌症痛经病理生理研究进展

    Institute of Scientific and Technical Information of China (English)

    江彩霞(综述); 程忠平(审校)

    2016-01-01

    子宫腺肌症是育龄妇女的常见妇科疾病,主要的病理特征为子宫肌层内存在子宫内膜腺体与间质细胞浸润性生长。临床主要表现为月经过多与逐渐加重的进行性痛经。子宫腺肌症痛经机制十分复杂,缩宫素及其受体、炎性因子、前列腺素等可通过激发子宫平滑肌细胞痉挛收缩引起痛经;而盆腔内脏器官痛觉传导则涉及腹下交感神经纤维(第10胸椎~第1腰椎)及副交感神经纤维(第2骶椎~第4骶椎)。%Adenomyosis is a common gynecologic disorder in women in their reproductive years,which is characterized by the growth of endometrial glands and stroma into the myometrium .The main clinical manifes-tations of adenomyosis are menorrhagia and progressive dysmenorrhea.The pathogenesis of dysmenorrhea in adenomyosis is extremely complicated,oxytocin and oxytocin receptor,inflammatory factors and prostaglandin F2α( PGF2α) may be responsible for increased uterine contractility and adenomyosis associated dysmenorrhea;the pelvic viscera( internal organs) receive nerve impulses from both sympathetic ( T10-L1 ) and parasympa-thetic ( S2-4 ) nervous systems.

  11. Combined Endometrial Ablation and Levonorgestrel Intrauterine System Use in Women With Dysmenorrhea and Heavy Menstrual Bleeding: Novel Approach for Challenging Cases.

    Science.gov (United States)

    Papadakis, Efstathios P; El-Nashar, Sherif A; Laughlin-Tommaso, Shannon K; Shazly, Sherif A M; Hopkins, Matthew R; Breitkopf, Daniel M; Famuyide, Abimbola O

    2015-01-01

    To evaluate the feasibility and impact of levonorgestrel intrauterine system (LNG-IUS) on treatment failure after endometrial ablation (EA) in women with heavy menstrual bleeding (HMB) and dysmenorrhea at 4 years. Cohort study (Canadian Task Force II-2). An academic institution in the upper Midwest. All women with HMB and dysmenorrhea who underwent EA with combined placement of LNG-IUS (EA/LNG-IUS cohort, 23 women) after 2005 and an historic reference group from women who had EA alone (EA cohort, 65 women) from 1998 through the end of 2005. Radiofrequency EA, thermal balloon ablation, and LNG-IUS. The primary outcome was treatment failure defined as persistent pain, bleeding, and hysterectomy after EA at 4 years. The combined treatment failure outcome was documented in 2 patients (8.7%) in the EA/LNG-IUS group and 19 patients (29.2%) in the EA group with an unadjusted OR of .23 (95% CI, .05-1.08). After adjusting for known risk factors of failure, the adjusted OR was .19 (95% CI, .26-.88). None of the women who underwent EA/LNG-IUS had hysterectomy for treatment failure compared with 16 (24%) in the EA group (p = .009); postablation pelvic pain was documented in 1 woman (4.3%) in the EA/LNG-IUS group compared with 8 women (12.3%) in the EA group (p = .24). One woman in the EA/LNG-IUS group (4.3%) presented with persistent bleeding compared with 15 (23.1%) in the EA group (p = .059). Office removal of the intrauterine device was performed in 4 women with no complications. LNG-IUS insertion at the time of EA is feasible and can provide added benefit after EA in women with dysmenorrhea and HMB. Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved.

  12. Effect of Bushenwenyanghuayu decoction on nerve growth factor and bradykinin/bradykinin B1 receptor in a endometriosis dysmenorrhea mouse model.

    Science.gov (United States)

    Jingwei, Chen; Huilan, Du; Ruixiao, Tong; Hua, Yang; Huirong, Ma

    2015-04-01

    To observe the effects of Bushenwenyanghuayu decoction (BD), a Traditional Chinese Medicine (TCM), on the serum concentration of nerve growth factor (NGF) and bradykinin (BK), and protein and mRNA levels of NGF and bradykinin B1 receptor (BKB1R) in a mouse model of endometriosis dysmenorrhea. Seventy-five experimental female BALB/c mice were randomly divided into five groups, 15 mice each: sham, model, BD high dose (61.67 g/kg), BD low dose (15.42 g/kg), and gestrinone (0.4 mg/kg) groups. All the mice except for those in the sham group underwent auto-transplantation surgery and were gavaged estradiol valerate (0.5 mg/kg, daily for 12 days) after surgery. On the 12th day, 1 h after administration, writhing response was induced by intraperitoneal injection of oxytocin at 2 U/mouse. The writhing frequency and latency were recorded and the volume of the ectopic foci was measured. The concentration of serum NGF and BK was detected by enzyme-linked immunosorbent assay, the protein expression of NGF and BKB1R was tested by immunohistochemistry and western blotting, and NGF and BKB1R mRNAs were detected by real-time PCR. Compared with the model group, the volume of the ectopic foci in the treatment groups was significantly lower (P model group were significantly increased (P model group (P model group (P model group (P < 0.01). NGF and BK/BKB1R may play an important role in the development of endometriosis-associated dysmenorrhea, and BD was found to inhibit the development of endometriosis and relieve dysmenorrhea by influencing NGF and BK/ BKB1R mRNA and protein levels.

  13. As Acupressure Decreases Pain, Acupuncture May Improve Some Aspects of Quality of Life for Women with Primary Dysmenorrhea: A Systematic Review with Meta-Analysis.

    Science.gov (United States)

    Abaraogu, Ukachukwu Okoroafor; Tabansi-Ochuogu, Chidinma Samantha

    2015-10-01

    Primary dysmenorrhea is the most common gynecological symptom reported by women and constitutes a high health, social, and economic burden. Chemotherapies, along with their side effects, have not yielded satisfactory outcomes. Alternative nonpharmacological interventions, including acupuncture and acupressure, have been advocated, but evidence regarding their beneficial effect is inconclusive. This study sought to obtain evidence on the effectiveness of acupuncture and acupressure interventions. Twelve electronic databases were searched by using menstrual pain intensity and quality of life as primary and secondary outcomes, respectively, with the PEDro guideline for quality appraisal. Data unsuitable for a meta-analysis were reported as descriptive data. The search yielded 38 citations, from which eight studies were systematically reviewed, four of the eight being eligible for meta-analysis. The systematic review showed moderate methodological quality with a mean of 6.1 out of 10 on the PEDro quality scale. Acupressure showed evidence of pain relief while acupuncture improved both the mental and the physical components of quality of life. In conclusion, physiotherapists should consider using acupuncture and acupressure to treat primary dysmenorrhea, but a need exists for higher quality, randomized, blinded, sham-controlled trials with adequate sample sizes to establish clearly the effects of these modalities.

  14. Effect of acupuncture on Deqi traits and pain intensity in primary dysmenorrhea: analysis of data from a larger randomized controlled trial.

    Science.gov (United States)

    Shi, Guang-Xia; Li, Qian-Qian; Liu, Cun-Zhi; Zhu, Jiang; Wang, Lin-Peng; Wang, Jing; Han, Li-Li; Guan, Li-Ping; Wu, Meng-Meng

    2014-02-21

    Deqi is a central concept in traditional Chinese acupuncture. We performed a secondary analysis on data from a larger randomized controlled trial (RCT) in order to assess the effect of acupuncture on deqi traits and pain intensity in primary dysmenorrhea. A total of 60 primary dysmenorrhea patients were enrolled and randomly assigned to one of three treatment groups. Acupuncture was given at SP6, GB39 or nonacupoint. Subjective pain was measured by a 100-mm visual analogue scale (VAS) before and after acupuncture. The Massachusetts General Hospital acupuncture sensation scales (MASS) with minor modification was used to rate deqi sensations during acupuncture. The results showed that VAS scores of pain after acupuncture were significantly decreased comparing to before acupuncture treatment in all three groups (P = 0.000). However, no significant differences were found among three groups at the beginning or end of acupuncture treatment (P = 0.928, P = 0.419). There was no statistical difference among three groups in terms of intensity of deqi feeling. The types of sensation were similar across the groups with only minor differences among them. Controlled-Trials.com ISRCTN24863192.

  15. YOGA EXERCISE PRESCRIPTION FOR IMPROVING THE SITUATION OF FEMALE STUDENTS DYSMENORRHEA%瑜伽运动处方对女大学生痛经状况的改善

    Institute of Scientific and Technical Information of China (English)

    张雷

    2011-01-01

    The incidence rate of dysmenorrhea female college students increasingly direct impact on their learning, quality of life. For physical health of college students today the situation is not optimistic, the paper has different levels of 53 students in the history of dysmenorrhea, Yoga exercise prescription for treatment, study Yoga to improve the situation of the role of dysmenorrhea, as the settlement and prevention of dysmenorrhea female college students to provide a new way, but also to enhance the students physical fitness, improve the quality of a mental sport for life-long exercise.%大学女生痛经的发生率已越来越高,直接影响到她们的学习和生活质量.针对当今大学生体质健康不容乐观的状况,作者对53名有不同程度痛经史的学生进行了瑜伽运动处方的治疗,研究了瑜伽对痛经状况的改善作用,为女大学生解决和预防痛经提供了一个新的方式,同时也为增强大学生体质、提升心理素质提供了一个适合终身锻炼的体育项目.

  16. The Analysis of Related Factors of Dysmenorrhea in 970 Vocational Stu-dents%970名高职女生痛经相关因素的分析

    Institute of Scientific and Technical Information of China (English)

    罗萍

    2016-01-01

    Objective To understand the eating habits of female students in higher vocational colleges, sleep, exercise, family history of impacts on primary dysmenorrhea and for dysmenorrhea of female physical education provides guidance direction. Methods On higher vocational colleges at all levels, professional girl dysmenorrhea factors survey, issued 981, 970, followed by sta-tistical analysis. Results For breakfast habits, menstrual period eat cold, spicy foods, sleep duration is short, often go to bed late, lack of physical exercise, family history of dysmenorrhea is dysmenorrhea factor. Conclusion Good eating habits and regular rest, moderate exercise can reduce the occurrence of dysmenorrhoea.%目的:了解高职女生的饮食习惯、睡眠、体育锻炼、家族史对原发性痛经的影响,为痛经女性生理健康教育提供指导性方向。方法采用问卷形式对某高职院校各年级、多专业的女生痛经相关因素进行调查,共发放981份,回收970份,而后进行统计分析。结果早餐习惯、经期食用生冷、辛辣刺激食物、睡眠持续时间短、经常迟睡、缺乏体育锻炼、有痛经家族史为痛经的影响因素。结论良好的饮食习惯、规律的作息、适度的锻炼能减少痛经的发生。

  17. The Clinical Experience of Guizhi Fuling Decoction in Treatment of Dysmenorrhea%桂枝茯苓方治疗痛经的临床体会

    Institute of Scientific and Technical Information of China (English)

    李静

    2016-01-01

    Objective To observe the clinical effect of guizhi fuling decoction in treating dysmenorrhea.Methods Selected 66 cases of dysmenorrhea from May 2014 to April 2015 in our hospital, which were divided into two groups according to the random number table method, each group had 33 cases. The observation group used the guizhi fuling decoction, the control group were treated with xiaoyao pill.Results Compared with the control group, the VAS score of the observation group was lower, the curative effect was better, the application of analgesic was less, the difference was statistically signiifcant (P<0.05).Conclusion Guizhi fuling patients can signiifcantly relieve menstrual pain, reduce dependence on painkillers in patients.%目的:观察桂枝茯苓方治疗痛经的临床效果。方法选择2014年5月~2015年4月我院收治的痛经患者66例,按照随机数字表法分为两组,各33例。观察组采用桂枝茯苓方治疗,对照组采用逍遥丸治疗。结果与对照组相比,观察组VAS评分更低,疗效优,应用止痛药少,差异有统计学意义(P<0.05)。结论桂枝茯苓方可缓解患者经期疼痛,减少患者对止痛药的依赖。

  18. Bleeding out the quality-adjusted life years: evaluating the burden of primary dysmenorrhea using time trade-off and willingness-to-pay methods.

    Science.gov (United States)

    Rencz, Fanni; Péntek, Márta; Stalmeier, Peep F M; Brodszky, Valentin; Ruzsa, Gábor; Gradvohl, Edina; Baji, Petra; Gulácsi, László

    2017-07-31

    Primary dysmenorrhea (PD), or painful menstruation in the absence of identified uterine pathology, affects 5 to 9 in every 10 reproductive-aged women. Despite its high prevalence, just a few studies with very small patient numbers have focused on health-related quality of life impairment in PD. We aimed to assess health-related quality of life values for a severe and a mild hypothetical PD health state using 10-year time trade-off and willingness-to-pay methods. In 2015, a nationwide convenience sample of women, aged between 18 and 40 years, was recruited using an Internet-based cross-sectional survey in Hungary. Respondents with a known history of secondary dysmenorrhea were excluded. Data on 1836 and 160 women, with and without a history of PD, respectively, were analysed. Mean utility values for the severe and mild health states were 0.85 (median 0.95) and 0.94 (median 1), respectively. Participants were willing to pay a mean of €1127 (median €161) and €142 (median €16) for a complete cure from the severe and mild PD health states. Compared with the non-PD group, women with PD valued both health states worse according to willingness to pay (P < 0.05) but similar in the time trade-off. It seems that PD substantially contributes to the quality-adjusted life year loss in this age group, which is comparable with losses from chronic diseases such as type 1 diabetes, asthma, atopic eczema, or chronic migraine. Our findings provide a useful input to cost-effectiveness and cost-benefit analyses of PD treatments.

  19. Menstrual Cramps (Dysmenorrhea)

    Science.gov (United States)

    ... them. The electrodes deliver a varying level of electric current to stimulate nerves. TENS may work by raising the threshold for pain signals and stimulating the release of endorphins, your body's ...

  20. Dysmenorrhea: Painful Periods

    Science.gov (United States)

    ... or the hormonal intrauterine device can be tried. Gonadotropin-releasing hormone agonists are another type of medication that may ... that form in the muscle of the uterus. Gonadotropin-releasing Hormone Agonists: Medical therapy used to block the effect ...

  1. Comparison of the effects of acupressure and self-care behaviors training on the intensity of primary dysmenorrhea based on McGill pain questionnaire among Shiraz University students

    Science.gov (United States)

    Behbahani, Bahar Morshed; Ansaripour, Lala; Akbarzadeh, Marzieh; Zare, Najaf; Hadianfard, Mohammad Javad

    2016-01-01

    Background: Dysmenorrhea is one of the common problems during reproductive ages, with prevalence rate of 60–90%. This study aimed to compare the effects of acupressure at Guan yuan (RN-4) and Qu gu (RN-2) acupoints, self-care behaviors training, and ibuprofen on the intensity of primary dysmenorrhea based on McGill pain questionnaire. Materials and Methods: In the randomized clinical trial, 120 females, aged between 18 and 25 years, with primary dysmenorrhea, randomly selected from five dormitories of Shiraz University, Shiraz, Iran were screened and randomized into acupressure group, in that pressure was applied for 20 min over the 1st 2 days of menstruation for two cycles. In the second group, the training group took part in four educational sessions each lasting for 60–90 min and control group received ibuprofen 400 mg. The intensity of pain before and after the intervention was measured using short-form McGill pain questionnaire. The data were entered into the SPSS statistical software (version 16) and analyzed using Kruskal–Wallis test, paired t-test, and Chi-square test. Results: A significant difference was found in the mean intensity of pain before and after the intervention in all the three study groups. The mean score of pain intensity was 10.65 ± 5.71 in the training group, 19 ± 5.41 in the control group, and 14.40 ± 6.87 in the acupressure group after the intervention. The results of Kruskal–Wallis test revealed that both interventions were more effective compared to consumption of ibuprofen. Conclusion: Training and acupressure were more effective than ibuprofen in the reduction of dysmenorrhea. Thus, they can be considered as trainable methods without side effects in adolescent girls. PMID:28250781

  2. 浅析温中理气法在痛经外敷治疗中的运用%Clinical application of the Wenzhong Liqi method in the topical treatment of dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    林唐唐; 潘海燕

    2012-01-01

      目的:分析目前痛经中药外敷治疗研究中主要药物的功效,总结中药外敷治疗痛经的主要治疗原则,为临床提供理论指导。方法:通过对近年来中药外敷治疗痛经的文献进行综述并对其用药机理进行分析,从而得出其治疗原则。结论:温中理气法为中药外敷治疗痛经的主要治疗原则。%  Objective: To analyze the efficacy of the main medicine in TCM topical therapy, and summarize the main principles of treatment of TCM topical in treating dysmenorrhea, to provide theoretical guidance for the clinical. Methods: In recent years, literature of TCM topical in treating dysmenorrhea was reviewed and the mechanism of their medication was analyzed, so as to arrive their treatment principles. Conclusion: The Wenzhong Liqi method was the main principles of treatment of TCM topical in treating dysmenorrhea.

  3. 女大学生原发性痛经的多因素Logistic回归分析%Logistic regression analysis on the multi-factors of primary dysmenorrhea of female college students

    Institute of Scientific and Technical Information of China (English)

    陈丽娟; 闫妍

    2014-01-01

    Objective:To investigate the relative factors of the primary dysmenorrhea of college female students. Methods:Taking class as a group in the method of chester sampling, 1574 female college students randomly were surveyed by self-made questionnaires. And relative factors influencing dysmenorrhea were statistically analyzed. Results: In 1574 selected subjects, the incidence of primary dysmenorrheal in female college students was 65.0% (1023/1574), including 757 mild cases (74.0%), 192 moderate cases (18.8%), 74 severe cases (7.2%). According to Logistic regression analysis, mother with history of dysmenorrhea [OR=1. 352, 95% CI (1.087~1.569), P25 [OR=0.695, 95% CI (0.554~0.951), P8 h [ OR=0. 331, 95% CI ( 0. 225~0. 452 ) , P25[OR=0.695,95%CI(0.554~0.951),P8h [OR=0.331,95%CI(0.225~0.452),P<0.05]是原发性痛经的保护因素。结论:女大学生的原发性痛经发生率较高,不良社会心理环境是引起女大学生原发性痛经的主要危险因素,避免体重偏低和充足睡眠可预防痛经的发生。

  4. Relationship between Dysmenorrhea and Mental Health,Coping Style,Sleep of Girls in Secondary Vocational School%中职女生痛经与心理健康、应对方式、睡眠的关系

    Institute of Scientific and Technical Information of China (English)

    杨芳; 王继华; 黄腊英; 陈跃飞

    2014-01-01

    目的:探讨中职女生痛经与心理健康、应对方式和睡眠状况的关系,为进一步干预提供科学依据。方法随机选择某中职卫校403名女生,用痛经情况问卷、症状自评量表(SCL-90)、简易应对问卷(SCSQ)和睡眠状况自评量表(SRSS)进行调查。结果中职女生痛经发生率为56.58%,农村、有痛经家族史、月经初潮年龄相对较大女生痛经发生率相对较高(χ2=5.653,33.426,9.931;P<0.05);SCL-90评分,除强迫、敌对和精神病性因子外,其余各因子分和阳性项目数,痛经组均高于无痛经组(t=4.079,5.229,8.923,4.899,4.360,2.154,8.483;P<0.05);痛经组SCSQ的积极应对维度分低于无痛经组,消极应对维度分和SRSS总分高于无痛经组( t=-14.186,15.315,7.400;P<0.001)。结论中职女生痛经发生率较高,痛经家族史、初潮年龄和户籍与痛经有关联,痛经学生心理健康水平较低,多采用消极应对方式,睡眠状况较差。%Objective To explore the relationship between dysmenorrhea and mental health ,coping style,sleep state of girls in sec-ondary vocational school ,and provide a scientific proof for further intervention .Methods A total of 403 girls were randomly selected out from girls of a secondary vocational health school .They were investigated with the questionnaire about dysmenorrhea condition and were evaluated with the Symptom Checklist 90 ( SCL-90 ) , Simplified Coping Style Questionnaire ( SCSQ ) and Self -Rating Scale of Sleep (SRSS).Results The positive rate of dysmenorrhea in the girls was 56.58%.The rate in the girls to be in rural or to have a positive family history of dysmenorrhea or a elder age of menarche was relatively higher (χ2 =5.653,33.426,9.931;P<0.05).The factors scores and the number of positive item of SCL -90 but the factors of compel ,hostility and psychoticism in the

  5. 中医辨证分期治疗原发性痛经81例临床疗效观察%Clinical observation on treating 81 cases of primary dysmenorrhea in TCM

    Institute of Scientific and Technical Information of China (English)

    张秀芹

    2013-01-01

    Objective:To investigate the TCM treatment of primary dysmenorrhea. Methods:February 2011 to September 2012, 81 patients with primary dysmenorrhea were collected, aged 16 to 25 years. Duration of 2 months to 3 years. Clinical manifestations of lower abdominal pain before and after menstruation was shown, some patients come with headache, nausea, vomiting or diarrhea. Gynecological examination found no positive signs;in some patients mild lower abdominal tenderness was found. Mild dysmenorrhea was given the Xuefu Zhuyu decoction orally, moderate dysmenorrhea given the Siwu decoction orally, severe dysmenorrhea was given the Taohong Siwu decoction orally for three months. Results:81 patients were followed up for 4 to 9 months. Accordance with the“TCM Syndrome Diagnostic efficacy standards”dysmenorrhea evaluated the efficacy evaluation criteria, 73 cases were cured, improved in 8 cases. Conclusion:TCM treatment of primary dysmenorrhea installments, effective and reliable, easily accepted by patients, worthy of clinical application.%目的:探讨中医辨证分期治疗原发性痛经的临床疗效。方法:2011年2月~2012年9月,采用中医辨证分期治疗原发性痛经患者81例。年龄16~25岁,中位数19岁。病程2个月~3年,中位数1年。临床表现为经期或经行前后下腹部疼痛、坠胀,部分患者伴头痛、恶心、呕吐或腹泻。妇科检查无阳性体征发现,部分患者下腹部轻微压痛。轻度痛经给予血府逐瘀汤口服,中度痛经给予四物汤口服,重度痛经给予桃红四物汤口服。治疗1个月经周期为1个疗程,连续治疗3个疗程。治疗结束后随访观察并评价疗效。结果:本组81例患者均获得随访,随访时间4~9个月,中位数6个月。按照《中医病证诊断疗效标准》中痛经的疗效评定标准评价疗效,本组治愈73例,好转8例。结论:采用中医辨证分期治疗原发性痛经,疗效可靠,患者易

  6. Observation of the Curative Effect of Since the Quasi Square for Treating Dysmenorrhea%自拟方治疗痛经的疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘海洋

    2015-01-01

    Objective To observe the curative ef ect for the treatment of dysmenorrhea. Methods From June 2010 to February 2010 in our hospital of traditional Chinese medicine outpatient treatment to patients with blood stasis type of dysmenor hea haemor heological nature of the treatment. Treatment according to the state administration of traditional Chinese medicine after the release of the evaluation of disease diagnosis curative ef ect of traditional Chinese medicine standard therapeutic ef ect. Results The cure 34 cases, 25 cases ef ectively, the total ef ective rate was 92.18%. Conclusion The proposed treatment of dysmenor hea high ef icient, worth clinical promotion.%目的:观察自拟方治疗痛经的疗效。方法对自2010年6月~2013年2月到我院中医门诊救治的寒凝血瘀型痛经患者行自拟方治疗。治疗结束后根据国家中医药管理局发布的《中医病症诊断疗效标准》评价治疗效果。结果治愈34例,有效25例,总有效率92.18%。结论自拟方治疗痛经有效率高,值得临床推广。

  7. The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

    Science.gov (United States)

    Wei, Shyh-Yuh; Chen, Li-Fen; Lin, Ming-Wei; Li, Wei-Chi; Low, Intan; Yang, Ching-Ju; Chao, Hsiang-Tai; Hsieh, Jen-Chuen

    2017-01-01

    The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the OPRM1 A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This OPRM1 A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience. PMID:28057931

  8. 单纯口服避孕药用于原发性痛经的临床疗效%Clinical Aplication of Simple Oral Contraceptive in the Treatment of Primary Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    杨琼秀; 熊平安

    2011-01-01

    Objective; To study the simple oral contraceptive (mawelon) in the treatment of primary dysmenorrhea treatment effect, and to investigate the changes of prostaglandins (PGE2, PGF2 alpha) levels in menstrual blood and in peripherial blood. Methods: Thirty-five cases of primary dysmenorrhea and 30 healthy subjects (control group) were included in this study, and both groups were sub-divided into a contraceptive group and a placebo (Vitamine E) group respectively. The clinical effect was analyzed, and prostaglandins levels in menstrual blood and in peripherial blood were compared. Results; The levels of prostaglandins in menstrual blood and in peripherial blood were higher in dysmenorrhea group than in cntrol group. After three menstrual cycles of simple oral contraceptive treatment, the levels of prostaglandins in menstrual blood and in peripherial blood were decreased both in dysmenorrhea group and in control group. And the clinical effective rate was higher in dysmenorrhea group versus that in control group. Conclusion · Oral contraceptives can reduce the prostaglandin level and is effective for the primary dysmenorrhea patients.%目的:研究单纯口服避孕药(妈富隆)治疗原发性痛经的效果.方法:收集我院门诊及病房原发性痛经患者35例、对照组(体检正常健康组)30例,痛经组及对照组均随机分为2个亚组,分别给予口服避孕药和安慰剂(维生素E)治疗.接受试验时收集患者月经血以及采集静脉血.治疗时间均为3个月经周期.检测月经血中前列腺素(PGE2、PGF2a)水平以及月经期静脉血中PGE2、PGF2a表达水平.结果:痛经组月经血中以及静脉血中前列腺素水平均高于正常对照组,经3个月经周期口服避孕药治疗后,痛经组口服避孕药后月经血及静脉血中PGE2、PGF2.水平均明显低于治疗前水平,差异有统计学意义;对照组口服避孕药后月经血中以及静脉血中前列腺素水平也低于对照组未口服避孕药

  9. Professor LIU Yu-Xin's Clinical Experience on Treating Dysmenorrhea with Cold Stagnation and Blood Stasis%导师刘宇新教授治疗寒凝血瘀型痛经临证体会

    Institute of Scientific and Technical Information of China (English)

    李铭欣; 刘宇新

    2012-01-01

    青春期原发性痛经是临床常见病,导师辨证求因,运用经前温补肾阳、经期祛瘀止痛、经后益气调经之法治疗寒凝血瘀型痛经,疗效显著.%Primary dysmenorrhea in adolescence is a clinical common disease, and professor LIU's diagnosis method is based on the overall analysis of symptoms, the methods of warming and invigorating kidney Yang before menstrual period, eliminating stasis and relieving pain in menstrual period, replenishing qi and regulating the menstrual function after menstrual period, are effective.

  10. Study on the treatment on primary dysmenorrhea with Wujibaifeng Pills%乌鸡白凤丸治疗原发性痛经的实验研究

    Institute of Scientific and Technical Information of China (English)

    郭起岳; 吴清和; 操红缨; 茹丽; 刘婵; 吴君; 郭重仪; 黄萍

    2016-01-01

    目的:探讨乌鸡白凤丸治疗原发性痛经的作用机制。方法利用缩宫素所致SD雌性大鼠痛经模型,观察乌鸡白凤丸不同剂量对大鼠扭体潜伏期、30 min内扭体发生率和扭体次数、子宫组织中PGF2α和PGE2含量的影响;采用常规方法制备大鼠离体子宫标本,通过BL‐420E生物机能实验系统,以大鼠子宫平滑肌条的平均张力和收缩频率作为评价指标,观察不同剂量乌鸡白凤丸对大鼠子宫肌收缩活动及缩宫素所致子宫痉挛的作用。结果乌鸡白凤丸能明显延长痛经模型大鼠扭体潜伏期,降低30 min内扭体发生率,减少扭体次数(P<0.01);能明显降低痛经模型大鼠子宫组织中PGF2α的含量(P<0.01),升高PGE2的含量( P<0.05),降低PG F2α/PG E2比值( P<0.01);可显著降低大鼠正常子宫和缩宫素引起的痉挛子宫平滑肌条的平均张力和收缩频率(P<0.01)。结论乌鸡白凤丸对原发性痛经造成的疼痛具有良好的改善作用,其作用机制可能与调节子宫组织内PG F2α和PG E2含量及抑制子宫收缩相关。%Objective To explore the therapeutic mechanism of Wujibaifeng Pills .Method By using the dysmenorrhea model of SD fe‐male rats induced by oxytocin ,the effect of different doses of Wujibaifeng Pills on latency period of twist body of rats was ob‐served ,the incidence and number of twist body in 30 mins were measured ,and the content of PGF2αand PGE2 of uterus was detec‐ted;by routine method ,the specimen of uterus were prepared ,according to the evaluate average tension and contractility frequency of uterine smooth muscle (by biological and functional experimental system‐BL‐420E) ,the contractility and cramping (oxytocin‐in‐duced) of uterus at different doses of Wujibaifeng Pills were explored .Result After administered Wujibaifeng Pills ,the latency pe‐riod of twist body of primary dysmenorrhea rats was

  11. Expressions of oxytocin receptor and estrogen receptor in adenomyosis and their relationships with dysmenorrhea%OTR、ER在子宫腺肌病中的表达及与痛经的关系

    Institute of Scientific and Technical Information of China (English)

    徐影; 赵艳晖; 邹颖刚; 张炜旸

    2012-01-01

    目的:探讨OTR、ER在子宫腺肌病患者在位及病灶组织中的表达及其与痛经的关系.方法:采用免疫组化法检测30例子宫腺肌病在位和异位内膜中OTR、ER的表达,以子宫正常肌层组织和在位内膜为对照.结果:在子宫腺肌病灶组织中OTR、ER的表达高于在位内膜组及对照组(P<0.05);在子宫腺肌病组的在位内膜和病灶组织中,痛经组OTR、ER的表达高于无痛经组及对照组(P<0.05);在不同痛经程度分组中OTR、ER的表达依次降低.在子宫腺肌病的在位内膜和病灶组织中,OTR、ER两者之间存在正相关关系.结论:子宫腺肌病组织中OTR、ER的表达随痛经程度增强而增加,在子宫腺肌病痛经的发生与发展间可能存在协同作用.%Objective; To explore the expression levels of oxytocin receptor and estrogen receptor in eutopic endometrium and ec-topic endometrium of the patients with adenomyosis and their relationships with dysmenorrhea Methods; Immunohistochemical staining was used to detect the expression levels of oxytocin receptor and estrogen receptor in eutopic endometrium and ectopic endometrium of 30 patients with adenomyosis, normal uterine muscular tissue and eutopic endometrium were designed as control group. Results: The expression levels of oxytocin receptor and estrogen receptor in ectopic endometrium of adenomyosis group were significantly higher than those in eutopic endometrium of adenomyosis group and control group ( P < 0.05); in eutopic endometrium and ectopic endometrium of adenomyosis group, the expression levels of oxytocin receptor and estrogen receptor in dysmenorrhea subgroup were significantly higher than those in non - dysmenorrhe-a subgroup ( P < 0.05 ) ; the expression levels of oxytocin receptor and estrogen receptor decreased sequently in the subgroups with different degrees of dysmenorrhea; in eutopic endometrium and ectopic endometrium of adenomyosis group, there was a positive correlation

  12. [Clinical Trials for Observing the Influence of Acupuncture Needle-stimulation Induced Sharp Pain on Curative Effect in Primary Dysmenorrhea Patients].

    Science.gov (United States)

    Ru, Shang-qing; Zhang, Peng; Li, Jing; Wang, Pei; Lin, Chi; Hu, Ni-juan; Hao, Jie; Hao, Mian-yi; Sun, Jon-jun; Wang, Ya-feng; Zhu, Jiang

    2016-04-01

    To observe the influence of acupuncture needle stimulation-induced sharp pain on the curative effect of acupuncture therapy for primary dysmenorrhea (PD) patients with cold damp stagnation syndrome (CDSS). A total of 87 PD patients with CDSS experiencing abdominal pain (> or =40 mm in visual analogue scale, VAS) were randomly asigned to deqi-expectation group and no-deqi-expectation group which were further divided into deqi-expectation + sharp pain (n = 31), deqi-expectation + no-sharp pain (n = 12), no-deqi-expectation + sharp pain (n = 17), no-deqi-expectation + no- sharp pain (n =27) groups. On the first day of abdominal pain attack, bilateral Sanyinjiao (SP 6) were punctured respectively with thicker needles with deeper insertion for deqi-expectation patients and thin filiform needles with shallow insertion for no-deqi-expectation patients. The needles were manipulated for 30 s with uniform reinforcing-reducing method for all the deqi-expectation patients, which was repeated once again every 10 min during 30 min of needle retention. The VAS was used to evaluate the patients' abdominal pain severity before treatment and 0, 10 min after acupuncture needle withdrawal. Following acupuncture stimulation of SP 6, the VAS scores of menstrual pain at both 0 min and 10 min after withdrawing acupuncture needles were significantly decreased in the deqi-expectation + sharp pain group, deqi-expectation + no-sharp pain group, no-deqi-expectation+sharp pain group and no-deqi-expectation + no-sharp pain group (Pdeqi-expectation + sharp pain group ( Pdeqi-expectation plus sharp pain and deqi- expectation + no-sharp pain groups, and between no-deqi-expectation + sharp pain and no-deqi-expectation + no-sharp pain groups (P>0.05). Acupuncture stimulation of SP 6 has an immediate analgesic effect in PD women with cold damp stagnation syndrome, which was not affected by needling-induced sharp pain, deqi-expectation, and thicker or thinner needle with shallow and deeper insertion.

  13. 止痛方配合耳穴贴压对痛经患者的疗效观察%Clinical efficacy of analgesic prescription combined with auricular plaster therapy for dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    韩冬梅; 廉印玲

    2016-01-01

    目的 观察止痛方配合耳穴贴压治疗痛经的效果.方法 收集本院门诊收治的痛经患者60例,分为治疗组和对照组,每组30例.治疗组采用止痛方(当归、熟地、赤芍、川芎、元胡、川楝子、蒲黄、五灵脂、乌药、川牛膝、小茴香、香附、枳壳、半夏、乳香)配合耳穴贴压疗法;对照组单用止痛方,比较两组的疗效.结果 治疗组总有效率93.3%,对照组总有效率73.3%,治疗组显著优于对照组(P<0.05).结论 痛方配合耳穴贴压治疗痛经的效果优于单用止痛方.%Objective To observe the efficacy of analgesic prescription combined with auricular plaster therapy in the treatment of dysmenorrhea.Methods Sixty dysmenorrhea patients treated in our hospital clinics from May 2013 to November 2011 were randomly divided into a treatment group and a control group,30 patients in each group.The treatment group adopted the analgesic prescription (Angelica sinensis,prepared Rehmannia glutinosa,Radix Paeoniae Rubra,Ligusticum chuanxiong,Corydalis yanhusuo,Melia toosendan,Pollen Typhae,feces of Trogopterus xanthipes,Lindera aggregata,Cyathula officinalis,Foeniculum vulgare,Cyperus rotundus,Citrus aurantium,and Pinellia ternate and frankincense) combined with auricular plaster therapy,and the control group was treated with the analgesic prescription alone.The curative effects of 2 groups were compared.Results The total effectiveness of the treatment group was 93.3%,and the total effectiveness of the control group was 73.3%.The treatment group was better than the control group,and there was statistically significant difference (P < 0.05).Conclusion The analgesic prescription combined with auricular plaster therapy has better clinical efficacy than the analgesic prescription alone for the treatment of dysmenorrhea.

  14. 维生素E治疗功能性痛经的疗效及安全性分析%Analysis of Curative Effect and Safety of Vitamin E in Treatment of Func-tional Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    张丽; 李勇

    2016-01-01

    Objective To study and research the effect of taking vitamin E orally in treatment of functional dysmenorrhea and evaluate its safety by the random and control method. Methods 100 cases of patients diagnosed with functional dysmen-orrhea from June 2013 to September 2014 were selected and randomly divided into two groups with 50 cases in each, the control group took non-steroidal anti-inflammatory drugs orally, the treatment group took vitamin E capsules three times per day and 10 mg per time, and the treatment effects of the two groups were respectively observed after 3 courses of treatment. Results The total effective rate in the treatment group after treatment was obviously higher than that in the control group with statistical significance, (82% vs 90%), P<0.05, and the evaluation of safety of the two groups was better. Conclusion Taking vitamin E orally can effectively treat functional dysmenorrhea and relieve pains for a longer time with good safety.%目的:利用随机对照的方法探讨和研究口服维生素E对功能性痛经的治疗效果及安全性评估。方法方便选取2013年6月—2014年9月期间该院收治的100例确诊为功能性痛经的患者,平均、随机地将其分为对照组和治疗组,每组50例患者,对照组口服非甾体抗炎药,治疗组口服维生素E胶囊,3次/d,10 mg/次,在3个疗程后分别观察两组的治疗效果。结果对照组在治疗后总有效率为82%;治疗组在治疗后总有效率为90%,治疗组总有效率明显高于对照组,差异有统计学意义(P<0.05);两组的安全性评估均较好。结论口服维生素E能有效地治疗功能性痛经,能更长时间缓解其疼痛,安全性较好。

  15. 针刺腹肌肌筋膜触发点治疗原发性痛经的疗效%Efficacy of acupuncture at abdominal myofascial trigger points for the treatment of patients with primary dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    刘琳; 黄强民; 刘庆广; 马彦韬; 赵佳敏

    2016-01-01

    Objective To retrospectively observe the efficacy of acupuncture at myofacial trigger points (MTrPs) in abdominal muscles for the treatment of patients with primary dysmenorrhea.Methods Sixtyfive patients with moderate or severe primary dysmenorrhea were treated with acupuncture therapy.The MTrPs in abdominal region were localized and repeatedly acupunctured and injected with 1% lidocaine,combined with auto-stretching exercise of abdominal muscles,0.5-1.0 min/time,3-5 times/d.VAS and effects were evaluated at the menstrual period after every acupuncture,and one year after last acupuncture.Results The effective rate was 63% (41/65 cases),100% (65/65 cases) and 100% (65/65 cases) after the acupuncture 1,2 times and 1 year after the treatment respectively.Conclusion Acupuncture at MTrPs in abdominal region combined with stretching exercise is effective for the treatment of primary dysmenorrhea.%目的 回顾性分析针刺腹肌肌筋膜触发点(MTrPs)治疗原发性痛经的效果.方法 选择中、重度原发性痛经患者65例,在腹肌肌筋膜定位MTrPs,并在月经中期对MTrPs进行针刺并注射1%利多卡因治疗,针刺时需引出腹肌局部跳动,反复针刺直至跳动消失.每次针刺结束后指导患者行腹肌牵张锻炼,保持0.5~1.0 min/次·3~5次/d.于每次治疗后的下一次月经期及最后一次治疗的1年后,评估VAS及疗效.当VAS≤3时,结束针刺治疗.结果 第1、2次治疗后及1年后随访有效率分别为63%(41/65例),100%(65/65例)和100%(65/65例).结论 针刺腹肌MTrPs结合腹肌牵张锻炼可有效缓解原发性痛经.

  16. Influences of Deqi on Immediate Analgesia Effect of Needling SP6 (Sanyinjiao) in Patients with Primary Dysmenorrhea in Cold and Dampness Stagnation Pattern: Study Protocol for a Randomized Controlled Trial.

    Science.gov (United States)

    Liu, Yu-Qi; Zhang, Peng; Xie, Jie-Ping; Ma, Liang-Xiao; Yuan, Hong-Wen; Li, Jing; Lin, Chi; Wang, Pei; Yang, Guo-Yan; Zhu, Jiang

    2015-01-01

    Deqi, according to traditional Chinese medicine, is a specific needle sensation during the retention of needles at certain acupoints and is considered to be necessary to produce therapeutic effects from acupuncture. Although some modern researches have showed that Deqi is essential for producing acupuncture analgesia and anesthesia, the data are not enough. It is a paper of a multicenter, randomized controlled study protocol, to evaluate the influences of Deqi on acupuncture SP6 in Cold and Dampness Stagnation pattern primary dysmenorrhea patients, in terms of reducing pain and anxiety, and to find out the relationship between Deqi and the temperature changes at SP6 (Sanyinjiao) and CV4 (Guanyuan). The results of this trial will be helpful to explain the role of Deqi in acupuncture analgesia and may provide a new objective index for measuring Deqi in the future study. This trial is registered with ChiCTR-TRC-13003086.

  17. Influences of Deqi on Immediate Analgesia Effect of Needling SP6 (Sanyinjiao in Patients with Primary Dysmenorrhea in Cold and Dampness Stagnation Pattern: Study Protocol for a Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Yu-qi Liu

    2015-01-01

    Full Text Available Deqi, according to traditional Chinese medicine, is a specific needle sensation during the retention of needles at certain acupoints and is considered to be necessary to produce therapeutic effects from acupuncture. Although some modern researches have showed that Deqi is essential for producing acupuncture analgesia and anesthesia, the data are not enough. It is a paper of a multicenter, randomized controlled study protocol, to evaluate the influences of Deqi on acupuncture SP6 in Cold and Dampness Stagnation pattern primary dysmenorrhea patients, in terms of reducing pain and anxiety, and to find out the relationship between Deqi and the temperature changes at SP6 (Sanyinjiao and CV4 (Guanyuan. The results of this trial will be helpful to explain the role of Deqi in acupuncture analgesia and may provide a new objective index for measuring Deqi in the future study. This trial is registered with ChiCTR-TRC-13003086.

  18. Analysis of history and characteristics of prescription of the umbilicus therapy in treating dysmenorrhea%脐疗治疗痛经方剂的历史沿革及特点

    Institute of Scientific and Technical Information of China (English)

    马玉侠; 陈晟; 谢晓佳; 于岩瀑; 高树中; 衣华强

    2013-01-01

    目的:探讨脐疗治疗痛经方剂的分布概况及特点.方法:收集整理古今文献中以脐疗治疗痛经的复方,建立数据库,通过数据筛选等功能分别对方剂的频次、剂型、药物使用等进行分析.结果:共收集方剂146首,涉及用药203味.按发展过程分为明清时代与近现代两个阶段,明清时期27首,占方剂总数18.49%;近现代119首,占81.51%.结论:根据方剂的分布及文献研究,脐疗治疗痛经方剂剂型演变特点为:明清时代以膏、丸、丹剂为主,近现代以散剂、贴剂为主,配制工艺逐渐由纷繁复杂向简单实用转变.%Objective;To discuss the history and characteristics of prescription of the umbilicus therapy in treating dysmenorrhea. Methods:Collecting ancient and modern literatures of treating dysmenorrhea,and establishing a database,using Microsoft Excel and analyze the frequency,dosage form of the prescription. Results: The development process of the umbilicus therapy in treating dysmenorrheal is divided into two stages, the Ming and Qing dynasties and modern. 27 cases in Ming and Qing dynasties, accounting for 18.49% of the total number of the collection of prescription. 119 cases in modern, accounting for 81.51% of the total number. Conclusion;The complicated formulations and preparation process in Ming and Qing dynasties are changed into simple and practical in modern society.

  19. 原发性痛经患者大脑皮质形态学变化的观察%Morphological alterations in gray matter related to primary dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    梁俊华; 沈爱群; 郑晓慧; 张敏; 冯威; 范明霞; 李怀芳

    2016-01-01

    目的 研究与原发性痛经相关的大脑皮质形态上的变化,同时探讨此种变化和原发性痛经之间可能关系.方法 选取2015年1至12月,在同济大学附属同济医院妇产科门急诊就诊的20例原发性痛经的患者及20例年龄及月经情况与之类似正常对照,行头颅高分辨率结构像的磁共振扫描,扫描后利用SPM8对两组的全脑灰质体积进行基于体素的统计学处理.结果 与对照组相比,痛经组在左、右侧海马旁回;左、右侧颞中回;左侧顶上小叶与顶下小叶;左侧中央后回;右侧顶上小时与顶下小叶等脑区灰质体积萎缩变薄.结论 原发性痛经患者的部分脑区灰质确实存在萎缩变薄,这些脑区功能均与大脑疼痛处理和躯体感觉有关,提示这些变化与原发性痛经相关.%Objective To investigate the structural changes of gray matter in women with primary dysmenorrhea (PDM) and discuss the potential relationships between the changes and etiology of the disease.Methods We used an optimized voxel-based morphometry (VBM) approach to compare total and regional volumetric changes of gray matter in 20 primary dysmenorrhea patients with 20 healthy age and menstrual cycle matched controls.All subjects were patients from the outpatient department of Tongji Hospital in 2015.Results Abnormal volumetric decreases of gray matter were found in the left and right parahippocampus,the left and right middle temporal gyms,the left and right superior parietal lobule,the left postcentral cortex,the left and right inferior parietal lobule,which involved in pain transmission,pain modulation and somatic sensation.Conclusion Abnormal gray matter volume changes are present in some encephalic regions of PDM patients.The functions of these regions are associated with pain modulation and somatic sensation,which suggests the changes are related with PDM.

  20. The effectiveness of connective tissue massage in the treatment of primary dysmenorrhea among young women Efetividade da massagem do tecido conjuntivo no tratamento da dismenorréia primária em mulheres jovens

    Directory of Open Access Journals (Sweden)

    Conceição Aparecida de Almeida Santos Reis

    2010-06-01

    Full Text Available OBJECTIVE: to evaluate the possible effectiveness of connective tissue massage for the non-medical treatment of primary dysmenorrhea. METHODS: this was a pilot observational cohort study. SETTING: University clinics. PARTICIPANTS: Seventy two young women presenting primary dysmenorrhea. INTERVENTION: Physiotherapy students in their last year at university and physiotherapists were trained for 20 hours to apply the massage. All volunteers were submitted to lumbar connective tissue massage twice weekly, while they were not menstruating, during the three menstrual cycles that followed admission. The following regions were manipulated: sacral, lumbar, last thoracic vertebrae and subcostal. INDICATORS: Pain score, use of pain medication and other menstrual systemic symptoms over time (before treatment, after each of the three menstrual periods during treatment, and in the second and in the third month following treatment. RESULTS: after the first treatment month, the pain score decreased significantly (pOBJETIVO: avaliar a possível efetividade da massagem do tecido conjuntivo para o tratamento não medicamentoso da dismenorréia primária. MÉTODOS: estudo piloto, do tipo observacional de coorte com setenta e duas mulheres jovens com dismenorréia primária em Clínica Universitária. Estudantes de fisioterapia e fisioterapeutas receberam treinamento de 20 horas para aplicar a massagem. Todas as voluntárias receberam massagem do tecido conjuntivo lombar duas vezes por semana, no período intermenstrual durante os três ciclos menstruais após a admissão. As regiões manipuladas foram: sacral, lombar, última vértebra torácica e sub-costal. Desfechos avaliados: Escore de dor, uso de medicamentos e ocorrência de outros sintomas sistêmicos ao longo do tempo (antes do tratamento, após cada ciclo menstrual durante o tratamento e nos dois meses após o tratamento. RESULTADOS: o escore de dor diminuiu significativamente após o primeiro mês de

  1. The efficacy and mechanism of Yoga treatment for primary dysmenorrhea suf-fered by female college students%瑜伽治疗女大学生原发性痛经的疗效及其机理

    Institute of Scientific and Technical Information of China (English)

    朱荣; 傅姗

    2013-01-01

    In order to observe the effects of Yoga exercise on the uterine blood flow and endometrial secretions PGF2α, PGE2 and AVP of female college students suffering primary dysmenorrhea during their menstrual periods, and to probe into the mechanism of dysmenorrheal symptom improvement made by Yoga exercise, the authors di-vided 20 female college students, who had been diagnosed as having primary dysmenorrhea by doctors, randomly into 2 groups, namely, an experiment group which contained 11 female college students and a control group which contained 9 female college students, let the testees in the experiment group do the Yoga exercise for 3 months, 3 times per week, 1 hour per time, while the testees in the control group did not do the Yoga exercise, before the ex-periment, after 2 months of experiment, and after 3 months of experiment, used a color Doppler ultrasound instrument to measure the changing of the resistance index (RI), pulsation index (PI) and ratio of peak systolic blood flow to peak diastolic blood flow (S/D) of the uterine and arcuate arteries of the testees within 24 hours after menses, applied the ELISA method to measure the PGF2α, PGE2 and AVP concentrations of menstrual blood, used a dysmenorrheal symptom evaluation form to evaluate the degree of menstrual pain before and after the experiment, and revealed the following findings:after 3 months of exercising, the S/D, RI and PI of the arcuate artery and the S/D and RI of the uterine artery and the degree of pain of the testees in the experiment group were all lower than those measured be-fore the experiment (P<0.05), in which the RI of the arcuate and uterine arteries and the degree of pain of the testees in the experiment group were significantly lower than those of the testees in the control group (P<0.05);the ratio of PGF2αto PGE2 and AVP concentration of menstrual blood of the testees in the experiment group were significantly lower than those of the testees in the control group (P<0.05). The

  2. Clinical Efficacy of Gestodene-ethinylestradiol Combined Vitamin B6 in the Treatment of Primary Dysmenorrhea%去氧孕烯炔雌醇联合维生素B6治疗原发痛经的临床疗效

    Institute of Scientific and Technical Information of China (English)

    朱仲初; 陈秀文

    2016-01-01

    目的::探究去氧孕烯炔雌醇联合维生素 B6治疗原发痛经的效果。方法:选取某院2013年9月~2014年10月收治的58例原发痛经患者,将其随机分成观察组和对照组,各29例。观察组通过去氧孕烯炔雌醇联合维生素 B6进行治疗,对照组通过单纯服用维生素 B6进行治疗,对比两组患者的治疗效果。结果:观察组的治疗总有效率为96.55%,明显优于对照组72.41%,差异有统计学的意义,P <0.05。结论:原发痛经通过去氧孕烯炔雌醇联合维生素 B6进行治疗,治疗效果较佳,值得临床方面应用和推广。%Objective:To explore the effect of gestodene-ethinylestradiol combined with vitamin B6 in the treatment of primary dysmenorrhea.Methods:58 patients with primary dysmenorrhea treated in a hospital from September 2013 October to were randomly divided into observation group and control group,29 cases in each group.The patients of observation group received desogestrel ethinylestradiol combined vitamin B6 treatment,and the patients of control group received simply vitamin B6 treatment;Then compared the treat-ment effect between the two groups.Results:The total effective rate of observation group was 96.55%,sig-nificantly better than that of control group (72.41%),which the difference was statistically significant (P <0.05).Conclusion:Primary dysmenorrhea treated with desogestrel ethinylestradiol combined with vitamin B6 has good curative effect,which is worthy of clinical application and promotion.

  3. 气血瘀滞型原发性痛经中医身心同治的临床疗效观察与分析%Observation on and Analysis of the Clinical Efficacy of Mental and Physical Therapy in Patients with Qi or Blood Stagnation Type of Primary Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    柴华; 王嘉梅

    2015-01-01

    Objective:To observe the clinical efficacy of mental and physical therapy on patients with Qi or blood stagnation type of primary dysmenorrhea.Methods:A total of 1 20 patients with Qi or blood stagnation type of primary dysmenorrhea were random-ly divided into the intervention group and the control group with 60 cases in each.Chinese medicine were given to both the inter-vention group and the control group,and additional psychological intervention was given to the control group.Comparison was made on the effective rate between the two groups after three courses of treatment.Results:The total effect rate of the intervention group was 93.33% and that of the control group was 80.00%,which means that the intervention group had a higher effective rate than the control group.The results are of statistical difference (P <0.05).Conclusion:Mental and physical therapy can effec-tively relieved the symptoms of Qi or blood stagnation type of primary dysmenorrhea.%目的:观察基于中医理论的身心同治方法对气血瘀滞型原发性痛经的临床疗效。方法:将120例气血瘀滞型原发性痛经的门诊患者随机分为治疗组和对照组各60例,2组均给予中药治疗,治疗组在中药治疗的基础上进行心理干预,3个月后观察2组有效率。结果:治疗组总有效率为93.33%,对照组总有效率为80.00%,治疗组总有效率高于对照组,且具有统计学意义(P <0.05)。结论:采用身心同治的综合干预方法治疗气血瘀滞型原发性痛经临床效果显著。

  4. 基于中药外敷VS非甾体类抗炎药治疗原发性痛经的临床疗效Meta分析%A Meta-analysis of clinical effcacy of TCM medicine external applicationsVS non steroidal anti-inlfammatory drugs on primary dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    吴婷婷

    2016-01-01

    Objective: To evaluate clinical effcacy of external application of TCM medicines VS non steroidal anti-inlfammatory drugs on primary dysmenorrhea. Methods: A systematic search in CNKI, Wanfang, VIP, Pubmed, EMBASE, and Cochrane library database was implemented; and documents period was from the beginning of the database establishment to March 2016; and related data was counted by statistical software. Results: The differences among all indexes were statistically signiifcant,P<0.01. Conclusion: Compared with non steroidal anti-inlfammatory drugs, clinical effciency of external application of TCM medicine on primary dysmenorrhea was better, could improve pain condition, with fewer recurrences.%目的:评价中药外敷VS非甾体抗炎药治疗原发性痛经的临床疗效。方法:系统检索CNKI、万方、维普、Pubmed、Embase、Cochrane library几大数据库,检索时间从数据库建库到2016年3月,并使用相关统计软件进行统计。结果:中药外敷VS非甾体抗炎药治疗原发性痛经的相关指标比较,差异均显著,P<0.01。结论:中药外敷治疗原发性痛经的有效率及疼痛状况改善优于非甾体抗炎药治疗,复发率也较服用非甾体抗炎药治疗低。

  5. Clinical Observation of the Leonurus artemisia Cream versus Dan’e Fukang Cream in the Treatment of Pri-mary Dysmenorrhea%益母草膏对比丹莪妇康煎膏治疗原发性痛经的临床观察

    Institute of Scientific and Technical Information of China (English)

    李明慧; 芦小娟; 张亚凤; 刘天舒

    2016-01-01

    OBJECTIVE:To compare the efficacy and safety of Leonurus artemisia cream and Dan’e fukang cream in the treat-ment of primary dysmenorrhea. METHODS:80 patients with primary dysmenorrheal were randomly divided into L. artemisia cream group (40 cases) and Dan’e fukang cream group (40 cases). L. artemisia cream group received L. artemisia cream 10 g, orally,twice a day. Dan’e fukang cream group received Dan’e fukang cream 10 g,orally,twice a day. The treatment was stated before 10 days of menstruation. 10 days was regarded as 1 treatment course,and it lasted for 6 courses. Cold drink and food were forbid during medication,washing face and feet with warm water,soaking feet with hot water if they can,paying attention to keep the lower abdomen and legs warm. If patients felt unbearable pain in menstruation,0.3 g Ibuprofen sustained release capsule was given,orally twice a day. Clinical efficacy,symptom score(dysmenorrhea degree,abdominal pain,lumbosacral pain)before and af-ter treatment,dysmenorrhea duration,frequency of taking painkillers and the incidence of adverse reactions in 2 groups were ob-served. RESULTS:There were no significant differences in the total effective rate and the incidence of adverse reactions in 2 groups (P>0.05). Before treatment,there were no significant differences in dysmenorrhea degree,abdominal pain,lumbosacral pain score,dysmenorrheal duration and frequency of taking painkillers in 2 groups (P>0.05). After treatment,the dysmenorrhea degree,abdominal pain,lumbosacral pain score in 2 groups were significantly lower than before,and Dan’e fukang cream group was lower than L. artemisia cream group with statistical sighificance(P0.05). CONCLUSIONS:Both L. artemisia cream and Dan’e fukang cream have good efficacy and safety in the treat-ment of primary dysmenorrhea,while Dan’e fukang cream is superior to L. artemisia cream in terms of improving clinical symp-toms.%目的:比较益母草膏与丹莪妇康煎膏治疗原发性痛经

  6. Evaluation study on integration effect of Taohong Siwu Tang in treating primary dysmenorrhea%桃红四物汤用于原发性痛经的整合效应评价研究

    Institute of Scientific and Technical Information of China (English)

    刘立; 段金廒; 华永庆; 刘培; 尚尔鑫; 唐于平; 宿树兰

    2012-01-01

    response, and calcium ion ( Ca2 + ) and nitric oxide ( NO) levels in uterine tissue of mice. In the isolated uterus contraction experiment, the oxytocin-induced isolated uterus contraction mice model was established to observe the effect of the samples on the isolated uterus contraction index. HPLC-DAD method was adopted for the content determination of effect sites. Result: According to the evaluation of the integration geological effect, beside TH-2 and TH4, other three active fractions ( TH-9, TH-10 and TH-11) extracted from Taohong Siwu Tang are the main effect sites. Their chemical components were analyzed and identified as monoterpene glycosides, phthalides, organic acids, etc. Conclusion: The effect sites of Taohong Siwu Tang on dysmenorrhea are TH-9, TH-10 and TH-11, which are 30%-50% active fractions obtained from water-soluble small-molecular fractions by gradient elution using ethanol through macroporous absorption resin. Compared with TH-10 and TH-11, TH-9 shows stronger effect, which may be related to the type and content of chemical components it contains.

  7. 中药穴位贴敷加红外线照射治疗血瘀型原发性痛经的临床研究%Clinical Research on Chinese Medicine Acupoint Application Combined with Infrared Irradiation Treating Primary Dysmenorrhea with Blood Stasis Type

    Institute of Scientific and Technical Information of China (English)

    钟小瑜

    2013-01-01

      Objective To observe the clinical effect of Chinese medicine acupoint application combined with infrared irradiation treating primary dysmenorrhea with blood stasis type. Methods The clinical data of 120 patients with primary dysmenorrhea with blood stasis type treated in the third hospital and songgang hospital of shenzhen from July 2009 to July 2012 were analyzed retrospectively and were divided into 2 groups. The control group were given peroral treatment of vitamins and analgesic drugs, and the observation group received the treatment of Chinese medicine acupoint application combined with infrared irradiation. The treatment effect of 2 groups were compared. Results In the observation group, the total effective rate was 95.3%, cure rate was 69.2%and cumulative score of pain was (11.42±3.71)scores. And in the control group, the total effective rate was 81.8%, cure rate was 34.5%and cumulative score of pain was (16.56±5.45)scores. The difference between 2 groups was significant(P<0.05). In addition, the comparison between two groups in incidental symptoms including blood clot, anomalous cycle, swollen breasts, dizziness, headache, nausea and vomit, cold limbs and sacrococcygeal pain had evident difference, (P<0.05), which had statistical significance. Conclusion The clinical effect of Chinese medicine acupoint application combined with infrared irradiation treating primary dysmenorrhea with blood stasis type is significant.%  目的探讨中药穴位贴敷加红外线照射治疗血瘀型原发性痛经的临床效果。方法选取深圳第三中医院和松岗人民医院2012年7月至2013年4月的120例血瘀型原发性痛经患者,将这120例血瘀型原发性痛经分成2组,对照组予以维生素和止痛药物口服治疗,观察组予以中药穴位贴敷敷加红外线照射治疗,比较两组治疗后的效果情况。结果观察组的总有效率为95.3%,治愈率为69.2%,疼痛积分为(11.42±3.71)分;而

  8. 原发性痛经患者外周血细胞因子和PGF2α的变化及临床意义%Changes in Peripheral Blood of Patients with Primary Dysmenorrhea Cytokines and PGF2α and Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    黄益于

    2015-01-01

    目的:探究原发性痛经患者外周血细胞因子和PGF2α的变化及临床意义。方法:选取2011年11月-2013年11月来本科就诊的50例原发性痛经患者作为观察组,选取同期来本院体检的50例健康月经期女性作为对照组。利用酶联免疫吸实验(ELISA)法对两组女性的经期外周血细胞因子和PGF2α的变化情况进行测定,比较两组经前、经中IL-10、IFN-r、PGF2α等指标的变化情况。结果:观察组经前1周内、经中IL-4、IL-5水平无明显变化(P>0.05),而经中IL-10、IFN-r、PGF2α水平高于经前(P0.05),但经中PGF2α水平高于经前(P 0.05), while the IL-10, IFN-r, PGF2 in the alpha level than the former (P 0.05), but the PGF2 alpha level was higher than before (P<0.05). The observation group’s IL-5, IL-10,IFN-r, PGF2 levels were significantly higher than those in control group(P<0.05).Conclusion:Primary dysmenorrhea and the pathogenesis of PGF2 alpha secretion, peripheral blood cell factors, cytokines in peripheral blood in patients with primary dysmenorrhea in vivo and PGF2 levels will appear abnormal changes in PGF2 secretion, and has a certain relationship with cell immune factor.

  9. 元胡白芷配方对大鼠外周血中致痛和镇痛物质的影响%Study on the effects of Yuanhuzhitong formula on pain-related substances in formalin-induced pain model and dysmenorrhea rats

    Institute of Scientific and Technical Information of China (English)

    刘群; 黄欣; 苏乐群

    2012-01-01

    OBJECTIVE To investigate the effects of Yuanhuzhitong formula on prostaglandins, |3-endorphin and monoamine transmitter of pain models of rats. METHODS Using tool drugs to measure analgesic effect of Yuanhuzhitong formula and detect the content of prostaglandins, β- endorphin and monoamine transmitter in formalin-induced pain model and dysmenorrhea rats. RESULTS Yuanhuzhitong formula had apparent analgesic effect in the experimental models; at the same time, the formula could reduce the content of PGF2a and the ratios of PGF2a and PGE2(P<0. 05)in the dysmenorrhea rats. In the formalin-induced pain model, the formula could reduce the content of β- endorphin and 5-HT, while there was no effect on the other monoamine transmitters. CONCLUSION Yuanhuzhitong formula alleviates pain through regulating the content of prostaglandins, β-endorphin and monoamine transmitter of pain models of rats.%目的:研究元胡白芷配方对疼痛大鼠血清中的前列腺素、β-内啡肽和单胺类递质的影响.方法:建立大鼠痛经和福尔马林疼痛模型,采用行为学评价元胡白芷配方的镇痛效果,测定大鼠外周血中的前列腺素类物质、β内啡肽和单胺类递质的含量.结果:元胡白芷配方药液对两种疼痛模型镇痛效果明显;给药后能降低痛经大鼠血中的前列腺素F2α的含量,降低PGF2α/PGE2 (P<0.05);福尔马林模型中,元胡白芷配方可降低外周血中β-内啡肽和5羟色胺的含量(P<0.05),对多巴胺及去甲肾上腺素无明显影响.结论:元胡白芷配方镇痛效果显著,对外周血中前列腺素、单胺类及β-内啡肽有显著影响,其作用具有多靶点的特点.

  10. Simultaneous determination of naringin,hesperidin and neohesperidin in dysmenorrhea patches by HPLC%HPLC 法同时测定痛经贴剂中柚皮苷、橙皮苷和新橙皮苷的含量

    Institute of Scientific and Technical Information of China (English)

    张丽君; 田军; 刘永

    2015-01-01

    目的:建立 HPLC 法同时测定痛经贴剂中柚皮苷、橙皮苷和新橙皮苷的含量。方法采用高效液相色谱法,以 Cosmosil-C18为色谱柱(5μm,4.6 mm ×250 mm);乙腈—0.1%磷酸(21∶79)为流动相;流速为1.0 mL· min -1;检测波长为283 nm;柱温为25℃;进样量为10μL。结果柚皮苷浓度在10.63~340 mg·L -1,橙皮苷浓度在7.81~250 mg·L -1,新橙皮苷浓度在8.13~260 mg·L -1范围内线性关系良好,平均加样回收率分别为98.01%、97.90%和98.60%。结论该方法简单、准确、可靠,可用于痛经贴剂的质量控制。%Objective To establish a method for simultaneous determination of naringin,hesperidin and neohesperidin in dysmenorrhea patches by HPLC.Methods The HPLC method was validated using a Cosmosil C18 analytical column(5 μm,4.6 mm ×250 mm)and the mobile phase was acetonitrile -0.1% phosphoric acid (21∶79)at a flow rate of 1.0 mL·min -1 with UV detection at 283 nm.The column temperature was kept at 25℃ and the injection volume was 10 μL.Results The linear ranges of naringin,hesperidin and neo-hesperidin were 10.63 ~340 mg·L -1 ,7.81 ~250 mg·L -1 and 8.13 ~260 mg·L -1 ,respectively.The average sample recovery rates were 98.01 %,97.90 % and 98.60 %,respectively.Conclusion The method is simple,accurate and reliable,which can be used for quality control of dysmenorrhea patches.

  11. 四物汤合失笑散加味联合吲哚美辛治疗气滞血瘀型原发性痛经40例%Modified SiWuTang and ShiXiaoSan Combined with Indomatacin in Treating 40 Cases of Primary Dysmenorrhea of Qi Stagnation and Blood Stasis Pattern

    Institute of Scientific and Technical Information of China (English)

    刘丽萍

    2013-01-01

    目的:观察四物汤合失笑散加味联合吲哚美辛治疗气滞血瘀型原发性痛经的临床疗效.方法:将80例患者随机分为观察组和对照组各40 例.2 组患者均给予吲哚美辛治疗,25 mg/ 次,4 次/d,口服.观察组同时在月经来潮前5 天给予四物汤合失笑散加减,水煎分服,1 剂/d,经后2 天停药.2 组均以1 个月经周期为1 个治疗周期,连续治疗3个周期后观察疗效.结果:全血高切黏度(200/s)、低切黏度(3/s)、血浆黏度2组治疗后均较治疗前明显改善(P<0.05),且治疗后观察组与对照组相比差异显著(P<0.05).观察组治愈率为52.50%,总有效率为92.50%;对照组治愈率为35.00%,总有效率为77.50%,2 组相比差异显著(P<0.05).结论:四物汤合失笑散加味联合吲哚美辛治疗气滞血瘀型原发性痛经疗效显著.%Objective: To observe curative effects of modified SiWuTang and ShiXiaoSan combined with indomatacin in the treatment for primary dysmenorrhea of Qi stagnation and blood stasis pattern. Method: Eighty patients were randomly divided into the observation group and the control group. Both groups received oral indomatacin, 25 mg each time, 4 times each day. The observation group took modified SiWuTang and ShiXiaoSan in the five days of the periods, decocted with water, one dose each day, till the 2nd day when the period finished. One menstrual cycle was one course of treatment. Curative effects were explored after three consecutive courses of treatment. Result: Whole blood high shear viscosity (200/s), low shear viscosity (3/s) and plasma viscosity of both groups were improved after treating than before treating significantly (P<0.05), and the observation groups showed significant difference compared with the control group after treating (P<0.05). Cure rate and total effective rate of the observation group were 52.50% and 92.50% , superior to 35.00% and 77.50% of the control group with significant difference (P<0.05). Conclusion

  12. 温针加穴位贴敷对寒湿凝滞型原发性痛经的疗效影响%Therapeutic effect of warm needling plus acupoint sticking therapy on primary dysmenorrhea due to cold-dampness retention

    Institute of Scientific and Technical Information of China (English)

    罗开涛; 占道伟; 范迪慧; 梁海丽; 金月琴

    2016-01-01

    Objective:To observe the clinical efficacy of warm needling plus acupoint sticking therapy for primary dysmenorrhea. Methods:A total of 60 eligible cases were randomly allocated into a treatment group (n=30) and a control group (n=30) according to their sequence of consultation. Patients in the treatment group were treated with warm needling combined with acupoint sticking therapy, whereas patients in the control group were treated with oral Ibuprofen (Fenbid) capsules. After two menstrual cycles, the visual analogue scale (VAS) score, COX menstrual symptom scale (CMSS) and clinical efficacy were compared between the two groups. Results:After treatment, the VAS and CMSS scores were significantly reduced in both groups, indicating that both treatment protocols can remarkably alleviate pain. There was a between-group statistical difference in comparing the CMSS score (P0.05). However, the follow-up visit showed between-group statistical differences in comparing VOA and CMSS scores (bothP Conclusion:Warm needling plus acupoint sticking therapy is a simple but effective therapy for primary dysmenorrhea. In addition, it causes fewer cases with relapse.%目的:观察温针加穴位贴敷治疗原发性痛经的临床疗效。方法:将符合条件的60例患者按就诊的先后顺序采用随机数字表分为治疗组和药物组,每组30例,治疗组采用温针加穴位贴敷,对照组口服芬必得胶囊,治疗两个月经周期,然后对比两组患者治疗后视觉模拟量表(visual analogue scale, VAS)评分、COX痛经症状量表(COX menstrual symptom scale, CMSS)评分及临床疗效。结果:治疗后,两组患者疼痛VAS评分及CMSS评分均明显降低,说明两种治疗方案均可明显缓解痛经患者的疼痛。治疗后, CMSS评分组间差异有统计学意义(P<0.05),而疼痛VAS评分差异无统计学意义(P>0.05)。随访时,两组患者疼痛VAS评分及CMSS评分差异均有统计学意义(均 P<0.01)。治疗组临床疗效

  13. 电针三阴交穴和血海穴对实验性类痛经大鼠痛调节机制的影响%Effect of Pain Modulatory System with Electroacupuncture “Sanyinjiao”, “Xuehai” on Experimental Dysmenorrhea Model Rats

    Institute of Scientific and Technical Information of China (English)

    任晓暄; 郭孟玮; 赵雅芳; 丁喜艳; 李春华; 嵇波; 朱江; 张露芬

    2011-01-01

    Objective: To explore whether the specificity of acupoint effects exists by research the effect on expression of k - opioid receptor in cornu dorsale medullae spinals of different segments and contents of ENK, p - EP in the periaque-ductal gray ( PAG) of midbrain of experimental dysmenorrhea model rats with electroacupuncture( EA) acupoints of different property innervated by the same nerve segment. Methods; 64 female SD rats were randomized into saline control group, model control group, EA "Sanyinjiao"(SP6) and "XueHai"(SP10) groups with 16 rats in each group. Except saline control group, the remaining groups were given consecutive subcutaneous injection of estradiol benzoate for 10 days, lh after the last administration, intraperitoneal injection of oxytocin each rat to create experimental dysmenorrhea rat model, saline control group gave the same dose of saline per day. On the 10th day, except saline control group and model control group, the remaining groups were given EA. Immediately, observing pain response - writhing response, and then detecting the expression of k - opioid receptor in T13 ,L1 ,L2 ,L6 ,S1 segments by immunohistochemical staining and the content of ENK, p - EP in PAG by ELJSA. Results; ①Writhing response: Compared with the saline control . group, writhing latency of model control group was significantly shortened and writhing time and writhing score of model control group were significantly increased(P <0.01). Compared with the model group, writhing latency of EA "Sanyin-jiao" group was significantly prolonged (P <0.05); Writhing score and writhing time decreased significantly in each group (P<0. 01). ②Expression of k -opioid receptor in cornu dorsale medullae spinals; Compared with the model group, the IOD of each segment increased significantly in EA "Sanyinjiao" and "Xuehai" group (P <0. 05, P < 0. 01); The IOD of L2 and SI segment increased significantly in EA "Sanyinjiao" group compared with in EA "Xuehai" group(P<0.01,P<0.05).

  14. Comparison of Acupressure Effect on Sanyinjiao Point with that of Vitamin E on Primary Dysmenorrhea

    Directory of Open Access Journals (Sweden)

    Z Bostani khalesi

    2009-10-01

    Results: The present study revealed that there was significant differences in the rate of pain during the cycles in both groups. There was a significant difference in pain intensity for each group before and after the treatment (P<0.05. Significant difference was found between two groups in the duration of pain in second months (P<0.05. Conclusion: The findings showed that acupressure at Sanyinjiao point can be used as an effective, available, cost effective intervention for reducing pain in dysmenorrheal.

  15. [Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac].

    Science.gov (United States)

    López Rosales, C; Cisneros Lugo, J H; Romo Enciso, L J; García Sandoval, M G

    1989-07-01

    Sixty patients with primary dismenorrhea were treated: 20 with nimesulide, 20 with fentiazac and 20 with mefenamic acid during three consecutive cycles under double blind design. The doses used in each group were: nimesulide or fentiazac 100 mg, every 12 hrs., mefenamic acid 500 mg. every 8 hrs. in all cases during 5 days, beginning a day before the beginning, of the menstruation. The pain evolution and the symptoms were evaluated three times a day using a scale from 0 to 10, so measure its intensity. Concluding, the nimesulide is useful in the treatment of pain associated with primary dismenorrhea, answering with little statistical advantage over the fentiazac and with bigger statistical advantage over the mefenamic acid. The tolerance was excellent with the three drugs studied.

  16. Differences in the Tongue Features of Primary Dysmenorrhea Patients and Controls over a Normal Menstrual Cycle

    National Research Council Canada - National Science Library

    Jihye Kim; Haebeom Lee; Hyunho Kim; Jong Yeol Kim; Keun Ho Kim

    2017-01-01

      Background. The aims of this study were to investigate the relationships between tongue features and the existence of menstrual pain and to provide basic information regarding the changes in tongue features...

  17. 痛经奇效食疗方十二则%Dietotherapy Recipes for Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    于辉

    2008-01-01

    1.乌豆蛋酒汤:乌豆(黑豆)60g,鸡蛋2个.黄酒或米酒100ml。将乌豆与鸡蛋加水同煮即可。具有调中、下气、止痛功效。适用于妇女气血虚弱型痛经,并有和血润肤功效。

  18. [Analysis of self-management education on improving the symptoms of female college students with primary dysmenorrhea in Shaoyang].

    Science.gov (United States)

    Tang, Juan; Xu, Huilan

    2016-04-01

    目的:探讨自我管理教育对改善女大学生原发性痛经症状及生命质量的效果。方法:整群抽取邵阳市两所高校的女大学生进行问卷调查,筛查出原发性痛经者,按基线调查的痛经程度的比例分层随机抽取2个校区中的痛经者,分为干预组和对照组。干预组(n=195)实施自我管理教育,对照组(n=195)不采取任何干预措施,观察6个月之后比较两组的痛经症状积分、视觉模拟评分(visual analogue scale,VAS)、痛经程度和生命质量。结果:干预后干预组的痛经症状积分、VAS、痛经程度均明显低于基线和对照组(P<0.05),生理健康总分和心理健康总分明显高于基线和对照组(P< 0.05)。结论:自我管理教育能有效改善原发性痛经者的痛经症状、疼痛程度和生命质量。.

  19. Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial

    Directory of Open Access Journals (Sweden)

    Mario I. Ortiz

    2016-10-01

    Full Text Available Resumen INTRODUCCIÓN La dismenorrea primaria es causada por la descarga de las prostaglandinas en el tejido uterino. Por lo tanto, los fármacos antiinflamatorios no esteroideos son la terapia inicial para la dismenorrea. El tratamiento para la dismenorrea puede incluir la administración de monoterapia o la combinación de fármacos. Sin embargo, la evidencia clínica científica sobre la eficacia de los medicamentos con dos o tres fármacos combinados es escasa o ausente. OBJETIVO Evaluar y comparar la eficacia y seguridad de dos combinaciones, en dosis fija y oral para el alivio de los síntomas de la dismenorrea primaria en mujeres mexicanas. Basados en la fisiopatología de la dismenorrea primaria, se utilizó una combinación comercializada en México de paracetamol, pirilamina y pamabrom. El comparador seleccionado fue un medicamento que contiene naproxeno sódico, paracetamol y pamabrom. MÉTODOS Se realizó un estudio en un solo centro, a doble ciego, experimental, paralelo y aleatorizado. Las pacientes con dismenorrea primaria que se incluyeron fueron mayores de 17 años de edad y con una intensidad del dolor mayor a 45 milímetros en una escala visual analógica. Las pacientes fueron aleatorizadas para recibir tabletas con naproxeno sódico, paracetamol y pamabrom o tabletas con paracetamol, pirilamina y pamabrom para un ciclo menstrual. Se evaluó la intensidad de la sintomatología y el dolor de las pacientes a lo largo de un período menstrual. Se utilizó análisis estadístico descriptivo e inferencial. RESULTADOS Se incluyó una población con intención de tratar de 91 mujeres, con una edad media de 21,3 ± 3,2 años la cual recibió tabletas de paracetamol, pirilamina y pamabrom. Otras 98 participantes, con una edad media de 21,0 ± 3,2 años, recibieron tabletas de naproxeno sódico, paracetamol y pamabrom. Las evaluaciones de dolor de las participantes con la escala visual analógica durante el ciclo menstrual demostraron una reducción significativa en ambos grupos de tratamiento (p0,05. CONCLUSIONES Los resultados mostraron que ambas combinaciones de fármacos no fueron diferentes en reducir el dolor dismenorreico. Del mismo modo, ambos tratamientos fueron bien tolerados. Por lo tanto, ambos tratamientos se pueden utilizar para el tratamiento de la dismenorrea primaria.

  20. 现代口服避孕药与痛经%Modern Oral Contraceptive Pills and Dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    雷贞武

    2007-01-01

    口服避孕药不仅有很好的避孕效果外,对许多与内分泌有关的妇科疾病也有良好的治疗作用,痛经就是其中之一。本文就口服避孕药治疗痛经的相关问题作一介绍。

  1. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial

    National Research Council Canada - National Science Library

    Rahnama, Parvin; Montazeri, Ali; Huseini, Hassan Fallah; Kianbakht, Saeed; Naseri, Mohsen

    2012-01-01

    .... The students were all residents of the dormitories of Shahed University. They were randomly assigned into two equal groups, one for ginger and the other for placebo in two different treatment protocols with monthly intervals...

  2. Assessment of Heat-sensitization at Guanyuan (CV 4) in Patients with Primary Dysmenorrhea: A Comparative Study between Moxibustion Sensation and Infrared Thermography

    Institute of Scientific and Technical Information of China (English)

    陈日新; 陈明人; 李巧林; 张波; 迟振海; 谢丁一; 洪珏

    2010-01-01

    目的:采用灸感与红外法对原发性痛经患者关元穴热敏态进行检测对比研究,探讨腧穴热敏态红外客观显示的可能性.方法:共纳入原发性痛经患者71例,比较灸感法与红外法对原发性痛经患者关元穴热敏态的检测差异.结果:原发性痛经患者关元穴区发生热敏化时,其红外辐射强度多数显示低温特征,与灸感法比较,其敏感性(真阳性率)为76.6%,特异性(真阴性率)为70.1%,准确性为74.6%;艾灸热敏态关元穴区后,产生明显纵向或横向扩散的红外辐射增强区域,与灸感法比较,其敏感性(真阳性率)为78.7%,特异性(真阴性率)为83.3%,准确性为80.3%.结论:原发性痛经患者关元穴区热敏态在一定程度上可被红外成像客观显示;艾灸热敏腧穴产生的腧穴热敏现象(如扩热、传热),除了被受试者主观感觉之外,在一定程度上也能被红外成像客观显示.

  3. Treating 40 Cases of Dysmenorrhea with Quick Painkiller%止痛快治疗功能性痛经40例

    Institute of Scientific and Technical Information of China (English)

    邵萍丽; 刘粉莉

    2006-01-01

    止痛快是我的老师陕西中医学院杨鉴冰教授治疗痛经的自拟方,笔者自2002年至2004年,对辨证为寒凝血瘀的功能性痛经治疗40例,效果颇佳。现报道如下:

  4. Evidence-Based Treatment for a Patient with Primary Dysmenorrhea%1例原发性痛经的循证治疗

    Institute of Scientific and Technical Information of China (English)

    程小尧; 杨荣秀

    2010-01-01

    目的 为原发性痛经患者提供合适的治疗方案.方法 计算机检索Cochrane图书馆(2009年第1期)、PubMed(1950年1月~2009年5月)、ACP Journal Club(OVID 1991年1月~2009年5月)等数据库,查找原发性痛经治疗相关的系统评价/Meta分析和随机对照试验,获取最佳证据用于临床.结果 共检出系统评价11篇、随机对照试验1篇.通过对检出文献进行分析,结合患者及家属的意愿,为患者提供了合理的治疗方案.结论 采用循证医学的方法,为原发性痛经提供合理的治疗方案,可有效提高治疗效果.

  5. Knowledge, Attitude, and Healthcare-Seeking Behavior Towards ...

    African Journals Online (AJOL)

    Knowledge, Attitude, and Healthcare-Seeking Behavior Towards. Dysmenorrhea among Female ... had negative attitude towards dysmenorrhea. Major effects of ..... to cite this article:***. Source of Support: Nil, Conflict of Interest: None declared.

  6. Influence of angelica essential oil aromatherapy on rats model of dysmenorrhea%当归精油香薰疗法对大鼠痛经模型的影响

    Institute of Scientific and Technical Information of China (English)

    殷玲; 徐莹; 叶红; 沈升万; 应立英

    2010-01-01

    [目的]探讨当归精油香薰疗法对大鼠痛经模型的影响.[方法]取Wistar雌性大鼠24只,随机分为香薰组和病理模型组各12只,先制备痛经模型,然后香薰组应用当归精油香薰10 d.在第11天注射缩宫素后观察两组30 min内大鼠扭体次数及血清β-内啡肽(β-EP)、血栓素B2(TXB2)、6酮前列腺素F1a(6-K-PGF1a)水平,并进行脾脏、胸腺病理学观察.[结果]香薰组大鼠30 min内扭体发生次数与模型组比较差异有统计学意义(P<0.01),香薰组血清中β-EP、6-K-PGF1a含量明显高于病理模型组(P<0.01),TXB2含量低于病理模型组(P<0.01),脾脏、胸腺的病理改变两组间无明显区别.[结论]当归精油香薰疗法对大鼠痛经模型有良好的镇痛作用,其作用机制可能与神经内分泌激素的综合性调节作用有关.

  7. Effect of ibuprofen sustained-release capsules on primary dysmenorrhea of female college students%布洛芬治疗女大学生原发性痛经的疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴国英; 陈步红

    2010-01-01

    目的 观察布洛芬缓释胶囊治疗女大学生原发性痛经的临床疗效.方法 回顾性分析60名女大学生服用布洛芬缓释胶囊治疗原发性痛经临床资料.结果 布洛芬缓释胶囊治疗原发性痛经总有效率为93.33%,无效率为6.67%,消化道不良反应8例,无其他不良反应.结论 布洛芬缓释胶囊治疗女大学生原发性痛经安全、有效,不良反应小.

  8. Randomized Controlled Study on the Analgesic Effect of Superficial Needling plus Electrostimulation of Sanyinjiao (SP 6) for Primary Dysmenorrhea%电浮针对原发性痛经镇痛作用的随机对照研究

    Institute of Scientific and Technical Information of China (English)

    职良喜

    2007-01-01

    目的:观察电浮针疗法对原发性痛经(PD)的镇痛作用及临床疗效.方法:171例PD患者,随机分为电浮针组、浮针组和药物组各57例,电浮针组采用电针刺激(疏波频率约 60 Hz、串长 2.5 s,密波频率约 60 Hz、串长 5 s,强度2~3 V,持续 30 min)与浮针疗法相结合,远取三阴交穴治疗,浮针组采用浮针疗法取三阴交穴治疗,药物组采用口服布洛芬缓释胶囊(0.3 mg/次,2次/日)治疗,3组均连续治疗3个月经周期,治疗后随访3个月经周期统计疗效.结果:纳入171例患者,163例完成试验,脱落8例.电浮针组、浮针组与药物组总有效率(ITT/PP)分别为94.74%/96.43%、91.23%/96.30%和77.19%/83.02%;电浮针组:近期治愈40/40,显效9/9,好转5/5,无效3/2;浮针组:近期治愈38/38,显效10/10,好转4/4,无效5/2;药物组:近期治愈10/10,显效27/27,好转7/7,无效13/9.ITT和PP分析结果一致:电浮针和浮针组的总疗效以及痊愈率显著优于药物组(P<0.01),电浮针与浮针组的总疗效以及痊愈率差异无显著性意义;短时间内电浮针组镇痛作用优于浮针组(P<0.05).结论:三阴交穴电浮针疗法对PD的镇痛作用具有高效快捷、安全无痛的特点,临床疗效显著优于口服布洛芬缓释胶囊.

  9. 心痛定与金佛止痛丸治疗原发性痛经疗效比较%Therapeutic effect comparison between nifedipine and Jinfo painkiller in the treatment of original dysmenorrhea

    Institute of Scientific and Technical Information of China (English)

    何小静

    2007-01-01

    目的 对心痛定与金佛止痛丸治疗原发性痛经进行临床疗效比较. 方法 对原发性痛经患者52例随机分为2组,治疗组27例,含服心痛定每次10 mg,每天3次,连服3 d;对照组25例,口服金佛止痛丸每次10g,每天2次,连服3 d;连续3个月经周期为一个疗程.进行临床疗效、复发率、不良反应等观察. 结果 治疗组总有效率96%,对照组总有效率84%,差异有统计学意义(P<0.05).复发率治疗组7%,对照组36%,差异有统计学意义(P<0.05),治疗组不良反应低于对照组. 结论 心痛定对治疗原发性痛经效果优于金佛止痛丸,且服用方便,显效快,复发率低,值得推广.

  10. 全蝎炮制的研究概况%Research on Pathogenic Factors and Pathogenesis of Primary Dysmenorrhea and Progress in Its Treatment with TCM and Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    滕坤; 李超英; 张海丰

    2003-01-01

    @@ 全蝎又名全虫,为钳蝎科动物东亚钳蝎Buthus martensii karsch的干燥体.性味辛、平;有毒,具有熄风镇痉、攻毒散结、通络止痛的功效.用于小儿惊风、抽搐痉挛、中风口喎、半身不遂、破伤风、风湿顽痹、偏正头痛、疮疡、瘰疬等症[1].药用价值高,临床应用广泛,现对其炮制方法作一综述,为进一步研究奠定基础.

  11. 原发性痛经与考试焦虑综合征相关性研究%The study of the relevance of primary dysmenorrhea and test-caused anxiety

    Institute of Scientific and Technical Information of China (English)

    常琳琳; 高玉霞; 李雅琴

    2007-01-01

    目的:揭示原发性痛经与考试焦虑的相关性.方法:选取护理学专业2003~2006级全日制本科女生295人.调查方法为发放自设问卷和考试焦虑测验量表(TAT).结果:自设问卷的回收率为91.86%,有效率为91.86%,TAT量表回收率为91.86%,有效率为91.19%.原发性痛经患病率约为56.45%,与2000年全国妇女月经生理常数协作组报道的56.06%很接近.同时对痛经者与非痛经者的焦虑程度进行了统计学处理,经过方差分析,χ2=4.96,P<0.05,两者比较有统计学意义,表明痛经者与非痛经者对考试的焦虑程度不同.结论:考试焦虑与原发性痛经互为因果,互相促进.心理因素与痛经相关.

  12. Discussion about traditional Chinese medicine causes and pathogenesis of moderate and severe primary dysmenorrhea based on questionnaire investigation%基于调查的中重度原发性痛经中医病因病机探讨

    Institute of Scientific and Technical Information of China (English)

    刘玉祁; 解秸萍; 苑鸿雯; 佘延芬; 朱江; 宋佳杉; 陈寅萤; 郑媛媛; 马增斌; 陈旭; 杨欢

    2012-01-01

    目的:对女大学生进行问卷调查以探讨中重度原发性痛经的中医病因病机.方法:以中重度原发性痛经女大学生为调查对象,调查其平时、痛经及证型分布情况并进行描述性统计分析.结果:163例被调查者中,有69.94%平时较怕冷,57.06%易手脚冰冷,77.30%喜热饮热食,83.44%每周运动少于3次.78.53%、64.42%的患者因吃冰品冷饮或用冷水洗衣服引起或加重腹痛,66.26%、74.23%因吃热食热饮或热敷腹部缓解腹痛.腹痛时69.33%的患者排便次数增加且大便变稀软;61.35%、56.44%左侧或右侧尺脉沉.68.10%的患者被诊断为寒湿凝滞证.结论:调查发现中重度原发性痛经的中医病因为寒邪,病机以外感寒邪而致寒湿凝滞胞宫为主.%Objective: To discuss traditional Chinese medicine (TCM) causes and pathogenesis of moderate and severe primary dysmenorrheal (PD) through questionnaire investigation among female college students. Methods: Female college students with moderate and severe PD were investigated. The ordinary times status, menstrual period conditions and pattern distribution of these patients were surveyed and analyzed by descriptive statistics. Results: Of all the 163 female college students with moderate and severe PD who finishied this investigation, at ordinary times, 69.94% averted to cold, 57.06% had cold limbs, 77.30% preferred warm food and drinks and 83.44% did physical activities less than 3 times a week. There were 78.53% and 64.42% patients whose menstrual pain were caused or aggravated by taking cold food and drinks or by washing clothes with cold water. While there were 66.26% patients whose menstrual pain were relieved by eating warm food and drinks and 74.23% by applying hot compress on lower abdomen. When menstrual pain occurred, 69.33% patients had more motions and more watery, soft stools than usual and 61.35% and 56.44% had sunken pulse in the left and right Chi position respectively. 68.10% was diagnosed as the pattern of accumulation of cold-dampness. Conclusion: This study suggested that for moderate and severe PD, the TCM cause is cold pathogen and the major TCM pathogenesis is accumulation of cold and dampness in uterus resulting from exterior cold pathogen.

  13. Clinical Observation of Combination Oral Contraceptive Pill for the Treatment of Primary Dysmenorrhea%复方口服避孕药治疗原发性痛经的临床观察

    Institute of Scientific and Technical Information of China (English)

    莫翠玲; 黎娟

    2010-01-01

    目的 研究复方口服避孕药物治疗原发性痛经导致疼痛和经期不适的疗效.方法 原发性痛经患者130例随机分为实验组(n=70)和对照组(n=60),实验组给予复方口服避孕药,对照组嘱其充分休息.分别用简式McGill疼痛问卷、目测类比疼痛评分和经期不适问卷评估服药前和服药1、3、6个周期后疼痛及经期不适的程度.结果 用药前两组的SF-MPQ、VAS、MDQ评分无统计学差异(P >0.05);服用1个月经周期后,实验组的各项指标评分较对照组有显著性差异(P <0.05);3个周期后,实验组的SF-MPQ、VAS评分较对照组有明显显著性差异(P <0.01),MDQ评分较对照组有显著性差异(P <0.05);6个周期后,实验组的SF-MPQ、VAS和MDQ评分较对照组有明显的显著性差异(P <0.01).结论 复方口服避孕药可有效缓解痛经带来的疼痛和不适.

  14. Painful menstrual periods

    Science.gov (United States)

    Menstruation - painful; Dysmenorrhea; Periods - painful; Cramps - menstrual; Menstrual cramps ... related activities for a few days during each menstrual cycle. Painful menstruation is the leading cause of ...

  15. Drug: D06700 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 4], (Atractylodes rhizome [DR:D06780] | Atractylodes lancea rhizome [DR:D06752]) Cold constitution...; Weak constitution; Disorder of menstruation; Dysmenorrhea; Climacteric disturbance Therap

  16. Investigating the Relationship between Mode of Delivery and Dysmenorrheal in 15-49 Year Old Women in Ahvaz

    Directory of Open Access Journals (Sweden)

    P Shahri

    2013-06-01

    Full Text Available Introduction: Approximately 50% of all women experience dysmenorrhea. It seems that childbirth can decrease menstrual pain; though, significant effect of delivery mode on dysmenorrhea has not been clearly explained. This study was carried out to determine the association between mode of delivery and dysmenorrhea frequency and severity. Methods: This is a cross-sectional and analytical study in which 384 eligible women were selected randomly from 9 health centers in Ahvaz. A questionnaire was used for data collection including two sections of demographic characteristics as well as obstetric and menstrual history. Severity of dysmenorrheal was investigated through verbal Multidimensional scoring system (VMSS and rated on a four-point scale: 0= no dysmenorrhea, 1=minimal, 2=moderate, 3=severe dysmenorrheal. The research data was analyzed through chi-square and McNamara. Results: Frequency of caesarean was 41.4% and frequency of dysmenorrhea was 51.6%, while before the first delivery, it was 79.4%. Before and after delivery most frequent scale in severity of dysmenorrheal involved 1 and 0 respectively. Using McNamara, there was a significant relationship between delivery and frequency of dysmenorrhea (P<0.001; though, type of delivery did not reveal any relationship to the frequency and severity of dysmenorrhea. There was a positive association among frequency of dysmenorrhea with education, ethnicity and occupation. Conclusion: According to the results, overall delivery declines dysmenorrheal, however; there is no difference between vaginal and caesarean delivery. Hence, further researches are required to explore this issue.

  17. Prevalence and factors associated with dysmenorrheal in health science students

    OpenAIRE

    Yáñez, Natalia; Bautista-Roa, Sandra-Johanna; Ruiz-Sternberg, Jaime-Enrique; Ruiz-Sternberg, Angela María

    2011-01-01

    Introduction: Dysmenorrhea has a prevalence between 60 and 93%. Different factors have been associated with it, such as age at menarche, body mass index, exercise, smoking and maternal history of dysmenorrhea, among others. Materials and methods: A cross-sectional study was conducted, based on an anonymous survey applied to a random sample of 127 women from the school of medicine and psychology at the Universidad Del Rosario. Results: The prevalence of  dysmenorrhea was 73%. 67% of participan...

  18. Drug: D06920 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ark [DR:D06689], Coptis rhizome [DR:D00092], Gardenia fruit [DR:D06731] Disorder of menstruation; Dysmenorrhea; Climacteric disturban...ce; Nervous disease Therapeutic category: 5200 Therapeut

  19. Drug: D07816 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available X18 M01AB05 M02AA15 S01BC03 Indication: For relief of mild to moderate pain, Migraine, Primary dysmenorrhea, Osteoarthritis..., Rheumatoid arthritis nonsteroidal antiinflammatory drugs (NSAIDs

  20. Estimulación eléctrica nerviosa transcutánea y dismenorrea primaria: un reporte de caso

    Directory of Open Access Journals (Sweden)

    Yaneth Herazo Beltrán

    2011-08-01

    Full Text Available Primary dysmenorrhea is pelvic pain during the menstrual cycle. The A delta and C fibers are sensitized by the increased release of prostaglandins and leukotrienes, thus causing pain. Transcutaneous Electric Nerve Stimulation (TENS is a physiotherapeutic strategy that mitigates pain sensation. Objective: The aim of this paper is topresent six cases of women in childbearing age who were diagnosedwith primary dysmenorrhea and received transcutaneous electricnerve stimulation. Materials and methods: A type of study, case report, was conducted with six women between 15 and 25 years of age with medical diagnosis of primary dysmenorrhea. We assessed pain intensity utilizing the visual analogue pain scale and located thepain by using a pain test map. Results: Pain intensity decreased inall treated women. Conclusion: Transcutaneous electric nerve stimulation (TENS is a physiotherapeutic strategy that mitigates painsensation. We conclude that high frequency TENSis a safe noninvasive modality to achieve reduction of pain in primary dysmenorrhea.

  1. Effect of female genital mutilation on female sexual function, Alexandria, Egypt

    Directory of Open Access Journals (Sweden)

    Manal Ibrahim Hanafi Mahmoud

    2016-03-01

    Conclusion: FGM was a risk factor for dysmenorrhea, obstructed labor and postpartum hemorrhage. Cases had lower mean sexual function; moreover, half of them convinced with FGM practice and with its continuation.

  2. A Survey of TCM Treatment for Endometriosis

    Institute of Scientific and Technical Information of China (English)

    HAN Yu-fen; HOU Li-hui; ZHOU Ya-jie; WU Xiao-ke

    2009-01-01

    @@ Endometriosis (EM) refers to the disorders caused by the endometrial tissues growing out. of the uterine cavity but in other parts of the body,which may include the progressive dysmenorrhea,dyspareunia,sterility,and abnormal menstruation.

  3. Drug: D02709 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ritis, Osteoarthritis, Primary dysmenorrhea, etc. cyclooxygenase-2 (COX-2) inhibito...gif Anti-inflammatory; Analgesic [cyclooxygenase (COX-2) inhibitor] [DS:H00445 H00630] ATC code: M01AH03 Indications: Rheumatoid arth

  4. Effect Of Relaxation Education, Based on Theory of planned behavior On students’ painful dismenorrhea

    OpenAIRE

    2015-01-01

    Background and Aim: Dysmenorrhea is one of the most common problems in females. “Theory of Planned Behavior” is one of the important theories that explains the main process of adopting health behaviors. The present study assessed applying “ the Theory of Planned Behavior in relaxation training regarding the  severity and duration of painful dysmenorrhea in Mashhad girl students. Materials and Methods: In this Semi-experimental study, 160  first year intermediate students of Mashhad city w...

  5. The Effect of 8 weeks aerobic exercise and yoga on primary dismenorrhea

    Directory of Open Access Journals (Sweden)

    T Siahpour

    2013-10-01

    Full Text Available Abstract Background & aim: Dysmenorrhea, menstrual cramps without physical pain is a common complaint in gynecology. The aim of this study was to investigate the effect of aerobic training on primary Dysmenorrhea in a period of 8 weeks. Materials & Methods: In the present clinical-trial study, 60 non-athlete girls with primary Dysmenorrhea were randomly divided into three groups: aerobic training, yoga and control groups. Based on the visual analog scale of pain intensity, pain duration and amount of analgesics administered was assessed before and after the period of primary Dysmenorrhea using a questionnaire. In this eight-week exercise program, the aerobic exercises group for 60 minutes in three weeks and yoga exercises group in three sessions per week for 60 minutes, the yoga breathing techniques, exercises, asana and relaxation techniques were performed. There was no intervention in the control group. Data were analyzed by Wilcoxon, Kruskal-Wallis and Mann Whitney (p0.05. There was a significant decrease in the analgesic consumption in the yoga group compared to the exercise group (p<0/05. Conclusion: Both aerobic and yoga are effective in the treatment of primary Dysmenorrhea, but yoga has a greater reduction property on drug dosage. Key words: primary dysmenorrhea, aerobic exercise, yoga exercise, female student

  6. A influência do método Pilates na flexibilidade muscular, sintomas e qualidade de vida em mulheres com dismenorreia primária = The influence of the Pilates method on muscular flexibility, symptoms, and quality of life in women with primary dysmenorrhea

    Directory of Open Access Journals (Sweden)

    Fonseca, Juliany Marques Abreu da

    2016-01-01

    Conclusões: Além de alívio álgico, os exercícios do método Pilates proporcionaram melhora da flexibilidade muscular, redução da dor e dos desconfortos associados à dismenorreia e influência positiva na qualidade de vida, indicando ser alternativa eficaz para o tratamento sintomático da dismenorreia primária

  7. Gambaran Pengetahuan Remaja Puteri Terhadap Nyeri Haid (Dismenore dan Cara Penanggulangannya

    Directory of Open Access Journals (Sweden)

    Erlina Rustam

    2015-01-01

    Full Text Available AbstrakDismenore merupakan gangguan menstruasi yang sering terjadi pada remaja putri. Untuk mengobatinya penderita cendrung menggunakan tindakan Farmakologi dan non Farmakologi. Telah dilakukan penelitian tentang gambaran pengetahuan dan cara menanggulangi dismenore pada remaja putri mahasiswi STIFARM Padang angkatan 2013 dengan jumlah responden 56 orang. Penelitian ini bersifat deskriptif dengan pengambilan data dilakukan dengan menggunakan kuesioner dan disajikan dalam bentuk tabel. Parameter yang digunakan adalah pengetahuan tentang menstruasi, dismenore dan tindakan yang dilakukan ketika mengalami dismenore. Dari penelitian didapat hasil yang tinggi dari pengetahuan remaja putri mengenai pengertian, lama dan penyebab menstruasi, pengetahuan yang rendah tentang siklus dan hormon yang berperan dalam menstruasi. Mempunyai pengetahuan yang tinggi terhadap dismenore seperti pengertian dismenore, usia yang sering mengalami dismenore, derajat dan penyebab dismenore. Tindakan yang dilakukan untuk mengatasi dismenore adalah tindakan non farmakologi (17,86%. Secara Farmakologi remaja putri menggunakan obat tradisional daun sirih (67,00%, Sedangkan yang memilih obat jadi adalah OJ-2 (40,00%. Efek samping obat yang dirasakan adalah mengantuk (56,52%. Alasan pemilihan obat adalah karena cepat menghilangkan nyeri (97,83%. Disarankan untuk melakukan penyuluhan tentang cara pengobatan dismenore baik secara Farmakologi maupun nonfarmakologi.Kata kunci: Dismenore, pengetahuan, pengobatanAbstractDysmenorrhea is the most common gynecologic health problem presented among female adolescents. To treat this condition, patients tend to either use pharmacologic or non farmacologic treatments available. A research had been done on the description of knowledge and how to over come a dysmenorrhea in female students of STIFARM Padang with sample 56 students. This is a descriptive study with data collection is done by using a questionnaire and presented in tabular form

  8. Relationship between selected health problems and exposures among women semiconductor workers in Malaysia.

    Science.gov (United States)

    Chee, H L; Rampal, K G

    2003-08-01

    A study conducted between 1998-2001 on the semiconductor industry in Penang and Selangor found that irregular menstruation, dysmenorrhea and stress were identified as the three leading health problems by women workers from a checklist of 16 health problems. After adjusting for confounding factors, including age, working duration in current factory, and marital status, in a multiple logistic regression model, wafer polishing workers were found to experience significantly higher odds of experiencing irregular menstruation. Dysmenorrhea was found to be significantly associated with chemical usage and poor ventilation, while stress was found to be related to poor ventilation, noise and low temperatures.

  9. Hubungan OAINS pada Pengobatan Dismenorea dengan Kejadian Dispepsia pada Mahasiswi Fakultas Kedokteran Universitas Andalas

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    Siti Dwiaulia Risnomarta

    2015-05-01

    Full Text Available AbstrakDismenorea merupakan salah satu keluhan ginekologi tersering yang membawa pasien datang ke dokter. Dismenorea terjadi 40-80% dan 5-10% nya membutuhkan pengobatan. Obat anti inflamasi non steroid (OAINS paling sering digunakan untuk pengobatan dismenorea primer. Namun efek samping sering terjadi terutama pada saluran cerna. Tujuan penelitian ini adalah untuk mengetahui hubungan OAINS sebagai pengobatan dismenorea dengan kejadian dispepsia pada mahasiswi Fakultas Kedokteran Universitas Andalas. Rancangan penelitian adalah analitik cross-sectional. Subjek penelitian berjumlah 62 orang yang diambil dengan menggunakan metode total sampling. Dari penelitian ini diperoleh jumlah responden yang mengalami dispepsia sebanyak 14 orang (22,6%. Penelitian ini menilai OAINS (jenis,jumlah, dan kombinasi pada pengobatan dismenorea dengan kejadian dispepsia. Derajat dispepsia yang dikeluhkan umumnya ringan. Hasil uji chi-square antara jenis OAINS pada pengobatan dismenorea dan kejadian dispepsia didapatkan p = 0,120. Hasil uji chi-square antara jumlah OAINS pada pengobatan dismenorea dengan kejadian dispepsia didapatkan p = 1,00. Hasil uji chi-square antara kombinasi OAINS pada pengobatan dismenorea dengan kejadian dispepsia didapatkan p = 0,125. Berdasarkan hasil penelitian didapatkan bahwa tidak terdapat hubungan antara jenis, jumlah, dan kombinasi OAINS pada pengobatan dismenorea dengan kejadian dispepsia.Kata kunci: dismenorea, OAINS, dispepsia AbstractDysmenorrhea is one of most common gynecological complaint that bring the patients come to see doctor. Dysmenorrhea occurs 40-80% and 5-10% need treatment. Non-steroidal anti-inflammatory drugs (NSAIDs are the most common treatment for primary dysmenorrhea. The side effects of NSAIDs often occur, especially in gastointestinal. The objective of this study was to determine the relationship of NSAIDs in the treatment of dysmenorrhea and dyspepsia incident in female students of Faculty of Medicine of

  10. Menstrual Cramps

    Science.gov (United States)

    ... symptoms cause you to miss school or other activities and over-the-counter medicine and other comfort measures don’t help, you should make an appointment with your health care provider. Tags: cramps , period , period tracker Related Content Menstrual Periods Painful Periods (Dysmenorrhea) I’ ...

  11. Prevalencia y factores asociados a dismenorrea en estudiantes de ciencias de la salud

    Directory of Open Access Journals (Sweden)

    Natalia Yáñez

    2010-12-01

    Full Text Available Introduction: Dysmenorrhea has a prevalence between 60 and 93%. Different factors have been associated such as age at menarche, body mass index, exercise, smoking and maternal history of dysmenorrheaamong others. Materials and methods: A cross-sectional study wasconducted, based on an anonymous survey applied to a random sample of127 women from the school of medicine and psychology at the Universidad Del Rosario. Results: The prevalence of dysmenorrhea was 73%. 67% of participants presenting with menstrual pain, reportedthey have taken medication for pain relief, (66.7% self medicated. 32.5% of respondents with dysmenorrhea have been absent from theiracademic or social work, with a percentage of school absenteeismdue to pain from 74.5% in at least one day. The risk of dysmenorrhoeawas 2.36 times higher in women who had mothers with this history (OR = 2.36, 95% CI 1.03 to 5.40. No associations with other factors were found. Conclusions: Dysmenorrhea is a disease with a high prevalenceand significant impact on school absenteeism. Maternal history ofdysmenorrhea was the only factor positively associated in this study.

  12. Menstrual and oral contraceptive use patterns among deployed military women by race and ethnicity.

    Science.gov (United States)

    Deuster, Patricia A; Powell-Dunford, Nicole; Crago, Mark S; Cuda, Amanda S

    2011-01-01

    Menstrual cycle patterns and concerns and oral contraceptive use in the combat environment were examined in Caucasian, Asian, Hispanic, and African American women to guide the development of educational resources for women soldiers. An anonymous, questionnaire was completed by 455 U.S. Army women-Caucasian (CA: n = 141); Asian (AS: n = 67); Hispanic (HIS: n = 67); and African American (AA: n = 184) to compare menstrual patterns and concerns, dysmenorrhea, and oral contraceptive patterns. Total menstrual concerns were significantly lower among African Americans relative to Caucasians, Asians, or Hispanics; Asians and Hispanics reported the greatest concern. Overall, secondary amenorrhea was noted by 14.9% of women. Severe dysmenorrhea rates were significantly lower in African American (6.1%) compared to Caucasian (11.6%), Asian (20.9%) and Hispanic (19.7%) women. Asian women reported missing less work-only 9.3% with moderate to severe dysmenorrhea missed work compared to 25.1% of all other women. Only 9.2% of women with mild, compared to 25.8% with moderate to severe (OR = 3.44; p ≤ 0.0001) dysmenorrhea sought health care. Less than 50% of women took oral contraceptive, and less than half of those women took oral contraceptive continuously. African Americans seemed to experience menstruation as less bothersome than others, despite no difference in the proportion with menstrual irregularities, mean duration of menses, and/or mean time between cycles.

  13. Menarche: Prior Knowledge and Experience.

    Science.gov (United States)

    Skandhan, K. P.; And Others

    1988-01-01

    Recorded menstruation information among 305 young women in India, assessing the differences between those who did and did not have knowledge of menstruation prior to menarche. Those with prior knowledge considered menarche to be a normal physiological function and had a higher rate of regularity, lower rate of dysmenorrhea, and earlier onset of…

  14. Clinical Experience in TCM Treatment of Chronic Cervicitis

    Institute of Scientific and Technical Information of China (English)

    周宜强; 范宏宇

    2002-01-01

    @@ Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemorrhage, pain in the lower limbs or lumbosacral region, dysmenorrhea and infertility.

  15. Clinical Application of Point Diji

    Institute of Scientific and Technical Information of China (English)

    栾继萍

    2004-01-01

    @@ Diji (SP 8) is a cleft point of the Spleen Channel of Foot-Taiyang. Its indications include abdominal pain, diarrhea, edema, dysmenorrhea and certain other symptoms caused by incoordination between the liver and the spleen. Either taking the point alone or together with some other adjunct points in clinical practice, the author has obtained satisfactory curative effects.

  16. Menstrual-Cycle and Menstruation Disorders in Episodic vs Chronic Migraine: An Exploratory Study.

    Science.gov (United States)

    Spierings, Egilius L H; Padamsee, Aliya

    2015-07-01

    Migraine is a chronic condition of recurring moderate-to-severe headaches that affects an estimated 6% of men and 18% of women. The highest prevalence is in those 18-49 years of age, generally when women menstruate. It is divided into episodic and chronic migraine depending on the total number of headache days per month being 14 or less or 15 or more, respectively. Migraine has been associated with menorrhagia, dysmenorrhea, and endometriosis, the latter particularly in chronic migraine. We conducted a questionnaire survey of 96 women with migraine, 18-45 years old, to determine the occurrence of the menstrual-cycle disorders, oligomenorrhea, polymenorrhea, and irregular cycle, and the menstruation disorders, dysmenorrhea and menorrhagia, in episodic vs chronic migraine. The prevalence of menstrual-cycle disorders in general (41.2 vs 22.2%) and dysmenorrhea (51.0 vs 28.9%) was statistically significantly higher in the women with chronic migraine than in those with episodic migraine (P ≤ 0.05) (not corrected for multiple comparisons). Whether the migraine was menstruation sensitive, that is, the headaches consistently occurred or worsened with menstruation, did not impact the prevalence of menstrual disorders. We conclude that chronic migraine is possibly more often than episodic migraine associated with menstrual-cycle disorders in general and dysmenorrhea, without impact on menstruation sensitivity of the headaches. Wiley Periodicals, Inc.

  17. How Do Health Care Providers Diagnose Menstrual Irregularities?

    Science.gov (United States)

    ... the vagina Sweet, M. G., Schmidt-Dalton, T. A., Weiss, P. M., & Madsen, K. P. (2012). Evaluation and management of abnormal uterine bleeding in premenopausal women. American Family Physician , 85, 35-43. [top] French, L. (2005). Dysmenorrhea. American Family Physician , 71, 285- ...

  18. The Menstrual Cycle and the Female Athlete.

    Science.gov (United States)

    Kolka, Margaret A.; Stephenson, Lou A.

    1982-01-01

    The effects of the menstrual cycle on the performance, heart rate, and body temperature of female athletes are discussed. Biological causes of menstrual problems such as dysmenorrhea and amenorrhea are explained. Research indicates that the higher the level of training achieved, the less effect each cycle phase has on physical performance. (PP)

  19. A study on the menstruation of Korean adolescent girls in Seoul

    Directory of Open Access Journals (Sweden)

    Jin Chul Lee

    2011-05-01

    Full Text Available Purpose : Westernized eating habits have been associated with earlyage menstruation, which increases the incidence of dysmenorrhea and premenstrual syndrome among adolescent girls. We therefore surveyed changes in menarche timing and the general menstrual characteristics of adolescent girls in Seoul, Korea. Methods : We surveyed 538 teenage girls who visited our hospital between July and November 2007. Items explored included age at menarche, general menstrual characteristics, occurrence of premenstrual syndrome and treatment thereof, and an association between present dysmenorrhea and a family history of the condition. Results : Average age at menarche was 12.6 years, with 29% (n=156 subjects beginning menstruation at age 12 years. The prevalence of dysmenorrhea was 82% (n=435. The main symptoms were abdominal (53.2% and lower back pain (34.2%, and 15.2% of girls who experienced such symptoms required medication. Present dysmenorrhea, and a family history thereof, were statistically correlated (P&lt;0.05. In addition, 58.8% (n=316 of teenage girls had symptoms of premenstrual syndrome. The most frequent psychological symptoms were fatigue (36.4% and nervousness (38.7%, whereas the most common physical symptom was menstrual cramps (46.5%. Most subjects (87.6% tolerated the symptoms of premenstrual syndrome without medication; 11.4% took medicines including painkillers; but only 0.1% of subjects visited a doctor. Conclusion : The average age at menarche in Korean girls was 12.6 years, thus younger than in the past. Most teenage girls experienced dysmenorrhea and premenstrual syndrome, but few consulted a doctor. Organized treatment plans are required to manage menstrual problems in teenage girls.

  20. Correlation between aromatase expression in the eutopic endometrium of symptomatic patients and the presence of endometriosis

    Directory of Open Access Journals (Sweden)

    Maia Jr H

    2012-02-01

    Full Text Available Hugo Maia Jr1,2, Clarice Haddad1,2, Julio Casoy11CEPARH, 2Itaigara Memorial Day Hospital, Salvador, Bahia, BrazilObjective: To investigate whether aromatase expression in the eutopic endometrium correlates with the presence and severity of endometriosis in patients with infertility and/or dysmenorrhea undergoing laparoscopy and hysteroscopy.Patients: The study involved 106 patients of reproductive age with symptoms of dysmenorrhea and infertility. Sixteen endometriosis-free asymptomatic patients were used as a control group.Methods: Concomitant laparoscopy and hysteroscopy was carried out in all cases. An endometrial biopsy was taken to determine aromatase p450 expression by immunohistochemistry. Endometriosis was staged according to the American Society of Reproductive Medicine classification.Results: Endometriosis was diagnosed by laparoscopy in 92/106 symptomatic patients. In this group, aromatase expression was detected in the eutopic endometrium of 66/92 patients with endometriosis (72% and in 13/14 (95% patients in the symptomatic, endometriosis-free group (P = 0.09. Aromatase expression was not detected in any patients from the control group. In the endometriosis group, aromatase expression was detected in the eutopic endometrium of 28/45 patients (62% with American Society of Reproductive Medicine classification stage 1 of the disease, in 11/14 patients (78% with stage II, 14/20 patients (70% with stage III, and in 12/13 patients (92% with stage IV; however, the difference was only statistically significant between stages I and IV (P = 0.04.Conclusion: Aromatase expression in the endometrium was associated with the presence of dysmenorrhea and infertility irrespective of the presence of endometriosis. When endometriosis was present, however, there was a tendency for aromatase expression to be positively correlated with dysmenorrhea severity.Keywords: aromatase, endometrium, endometriosis, Cox-2, dysmenorrhea

  1. Gynecologic pain related to occupational stress among female factory workers in Tianjin, China

    Science.gov (United States)

    Sznajder, Kristin K; Harlow, Siobán D; Burgard, Sarah A; Wang, Yanrang; Han, Cheng; Liu, Jing

    2014-01-01

    Background: Dysmenorrhea, dyspareunia, and non-cyclic pelvic pain are health concerns for factory workers in China and may be increased by occupational stress. Objectives: To estimate the prevalence and demographic and occupational factors associated with three types of gynecologic pain among female factory workers in Tianjin. Methods: The study included 651 female workers from three factories in Tianjin, China. Logistic regression models were estimated to determine associations between occupational stress and gynecologic pain. Results: Occupational stress including high job strain, exhaustion, and stress related to working conditions was a risk factor for gynecologic pain. High job strain and poor job security were associated with an increased risk for dysmenorrhea. Compulsory overtime and exhaustion were associated with increased non-cyclic pelvic pain. Working overtime and exhaustion were associated with increased dyspareunia. Conclusions: As China’s population of female factory workers grows, research on the reproductive health of this population is essential. PMID:24804338

  2. Skipping breakfast adversely affects menstrual disorders in young college students.

    Science.gov (United States)

    Fujiwara, Tomoko; Sato, Natsuyo; Awaji, Hiroyo; Sakamoto, Hiroko; Nakata, Rieko

    2009-01-01

    In the present study we conducted a questionnaire survey to examine the relationship between dietary habits and menstrual disorders in young women. Subjects were recruited from 315 college students and were classified as: Group I, eating breakfast; Group II, skipping breakfast; Group III, not eating fast foods; Group IV, eating fast foods; Group V, not eating processed foods; and Group VI, eating processed foods. The intensity of dysmenorrhea was scored using three grades. All participants were further divided into groups based on having regular or irregular menstruation, having premenstrual symptoms or not, and self-perception of good or poor general health. General health was poor in Groups II and VI, and dysmenorrhea scores were high in Groups II, IV and VI. The incidence of irregular menses was also high in Group II. However, there was no apparent relation between premenstrual symptoms and dietary habits. These findings suggest that skipping breakfast adversely affects menstrual disorders in young college students.

  3. Clinical Analysis of 144 Cases of Endometriosis%子宫内膜异位症144例临床预后分析

    Institute of Scientific and Technical Information of China (English)

    苏明兰; 杨法

    2014-01-01

    Objective To investigate the clinical characteristics of patients with endometriosis,treatment and prevention. Methods The clinical data of 144 patients with endometriosis were analyzed,and pelvic pain,dysmenorrhea and infertility patients were fol owed up for 2 to 3 years Phone . Results 144 patients underwent surgery,endometriosis,pelvic pain in patients with the defense team representing 54.5%,34.5%dysmenorrhea,infertility 37.5%,postoperative pelvic pain remission rate of 75.2%,50.5%response rate dysmenorrhea pregnancy rate of 63.5%. Conclusions Clinical features master EM timely surgical treatment after diagnosis is to relieve pelvic pain,dysmenorrhea,infertility effective means to improve the pregnancy rate.%目的:探讨子宫内膜异位症患者的临床特点、治疗方法及预防。方法对144例子宫内膜异位症患者的临床资料进行分析,并对盆腔痛、痛经和不孕患者进行电话随访2~3年。结果144例患者行手术治疗,子宫内膜异位症联防队员患者中盆腔痛占54.5%,痛经占34.5%,不孕占37.5%,术后盆腔痛症状缓解率75.2%,痛经症状缓解率50.5%,妊娠率63.5%。结论掌握EM的临床特点,确诊后及时进行手术治疗是缓解盆腔痛、痛经,提高不孕者妊娠率的有效手段。

  4. Preparation and clinical application of the Bawei Huayu mixture%八味化瘀合剂的制备与临床应用

    Institute of Scientific and Technical Information of China (English)

    马永明; 陈淑萍; 刘秋鹤

    2013-01-01

      目的:探讨八味化瘀合剂的制备与治疗产后胎盘、胎膜残留、痛经、闭经的临床疗效。方法:建立该制剂的质量控制方法;观察其治疗产后胎盘、胎膜残留、痛经、闭经的的疗效。结果:处方配伍及制备过程合理,治疗观察103例病例,胎盘、胎膜残留治愈率87.3%,显效98.2%。痛经有效率90.0%,闭经有效率66.6%。临床疗效显著。结论:八味化瘀合剂治疗产后胎盘、胎膜残留、痛经、闭经疗效确切,有临床推广应用价值。%Objective:To investigate the preparation of the Bawei Huayu mixture and the efficacy for treating postpartum residual placental membranes, dysmenorrhea, amenorrhea. Methods: Establishing quality control methods of the formulations, the efficacy was observed for treating postpartum residual placental membranes, dysmenorrhea, amenorrhea. Results: Prescription compatibility and preparation process was reasonable, 103 cases were observed and treated, the cure rate of postpartum residual placental membranes was 87.3%, and the markedly efficiency was 98.2%. The efficiency was 90.0% for treating dysmenorrhea, and was 66.6% for treating amenorrhea, clinical efficacy was significant. Conclusion:The Bawei Huayu mixture is effective in treating postpartum residual placental membranes, dysmenorrhea, amenorrhea, worthy of clinical application.

  5. Comparison of Norethindrone-Containing OCPs to Desogestrel OCPs and Depro-Provera in Women

    Science.gov (United States)

    1999-10-01

    women were due to pregnancy (2). Relative to treatment , the continuation of or restarting of oral contraceptive pills and related bleeding disorders...resolution of this problem (13,14,19). Another benefit of oral contraceptives, especially DOCA, is the effect on hirsutism (13,14,19). Several studies...comparative studies examining treatment efficacy of various contraceptive regimens have not been conducted. Although the etiology of dysmenorrhea has yet

  6. Drug: D02341 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available pain, Primary dysmenorrhea, Rheumatoid arthritis, Osteoarthritis, etc. cyclooxygenase-1 (COX-1) inhibitor [...c acid (USAN/INN) Target-based classification of drugs [BR:br08310] Enzymes Oxidoreductases cyclooxygenase-1... (COX-1) [HSA:5742] [KO:K00509] Meclofenamic acid [ATC:M01AG04 M02AA18] D02341 Meclofenamic acid (USAN/INN) cyclooxygenase...HSA:5742] [KO:K00509]; cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987];

  7. Women Aboard Navy Ships: A Comprehensive Health and Readiness Research Project. Volume 1

    Science.gov (United States)

    1996-12-31

    college students . There have been relatively few large, population-based studies of the association of behavioral and life style variables with...Stephens T, Sutton J, McPherson B. Exercise, fitness and health: a consensus of current knowledge . Champaign (IL): Human Kinetics Books, 1990. 18. Pronk N...the 15 million menstruating women in the United States suffer to one degree or another from dysmenorrhea and other menstrual and premenstrual

  8. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC

    OpenAIRE

    Bharati, Abinash C.; Sahu, Alakh N.

    2012-01-01

    Medicinal plants are widely being used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Biophytum sensitivum DC (Oxalidaceae) is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrhea. It is a small, flowering, annual herb with sensitive leaves. It grows throu...

  9. Première consultation de contraception chez les adolescentes

    OpenAIRE

    Beliard, Aude

    2016-01-01

    Adequate contraception prescription is mandatory for teenagers to avoid any unwanted pregnancy. Counselling and description of side effect improve compliance. Use of condom is important to avoid sexually transmitted infections. Combined estroprogestin contraception has multiple non-contraceptive benefits, e.g. dysmenorrhea improvement. Familial and personal history is needed before contraception prescription. Further consultation 3 months later has to be planned to evaluate compliance, side e...

  10. New Imaging Kit for Assessment of Estrogen Receptors with Single Photon Emission Computed Tomography

    Science.gov (United States)

    2006-09-01

    3Department of Obstetrics and Gynecology 1,2The University of Texas M. D. Anderson Cancer Center, Houston, Texas and 3Taipei Medical University...age are affected. Symptoms may include dysmenorrhea, pelvic pain, abdominal swelling associated with tenesmus and infertility . Despite there were...of women with pelvic endometriosis presenting with chronic pelvic pain or infertility . Fertil Steril 1997;67:238-43. 18 Submitted to Cancer

  11. A CASE-CONTROL EPIDEMIOLOGIC STUDY OF ENDOMETRIOSIS

    Institute of Scientific and Technical Information of China (English)

    韩美玲; 潘凌亚; 吴葆桢; 边旭明

    1994-01-01

    A case-control study involving 203 cases of pelvic endometriosis seen from 1987-1989,and 406 randomly selected and age-matched community controls was conducted in order to provide information relevant to effective prophylxaix of the disease.The diagnosis was confirmed by pathology from laparotomy and/or laproscopy.A questionnaire focused on menstrual,marital and reproductive status,professional exposurs and physical activities,and the results were analyzed by a conditional logistic regression model.Women characterized by earlier menarche (≤12 years)and longer period(≥8 days)were found to be saaociated with an elevated incurring risk,and a trend of increasing risk associated with primary dysmenorrhea(RR=2.1 for mild to moderate and RR=5.2 for severe dysmenorrhea),energetic physical activity during menstruation(RR=2.1),and allergic diathesis (RR=1.8)was seen.An inverse relationship was observed between the number of pregnancies and risk of endometrio-sis,and the protective effect was most significant when only the number of full-term pregnancies was counted.The risk factors of endometriosis are discussed,and intensive treatment of primary dysmenorrhea and avoidance of strenuous exercise during menstruation are identified as important as important measures in the prevention of endometriosis.

  12. Premature childbirth: pregnant women's characteristics of a population in the South area of São Paulo

    Directory of Open Access Journals (Sweden)

    Aline Zorzim Berger

    Full Text Available Abstract Objectives: to identify the characteristics of pregnant women who had premature child-birth (PPT in the South region of São Paulo city. Methods: a cross-sectional observational study with a data collection of 122 medical files on pregnant women who had PPT in 2013. The collected data were analyzed by a statistical package, Graphpad Prism 6. As for the variables that were shown to be significant in the multivariate regression, an analysis was performed in a dichotomous form by odds ratio. Results: the mean age of the pregnant women was 24.9 years old. Of the 122 pregnant women, 34.4% were included in the age group considered to be at risk by the Ministry of Health. The predominant race was mixed (46.2%. 41.8% were high school graduates. Regarding to personal background, the history on urinary infection was mostly mentioned (37.5%. In relation to family history regarding clinical conditions, 43% had diabetes history and 61% had hypertension. As for gynecological history, 37.5% reported having dysmenorrhea during menstrual cycles. Multivariate analysis was performed and found that particularly hypertension and dysmenorrhea were the most significant. Conclusions: Regarding to women´s risk factors for premature childbirth, the most determining factor was dysmenorrhea, followed by hypertension.

  13. Effect of near-infrared rays on female menstrual pain in Korea.

    Science.gov (United States)

    Lee, Jin-Min; Kim, Kye-Ha

    2017-09-01

    Most Korean women who experience menstrual pain have reported taking pain medicine and making use of complementary alternative therapies. However, because some interventions may cause side effects, more effective pain-relieving measures need to be identified. This study using a non-equivalent group design, evaluated the effects of near-infrared rays on dysmenorrhea among Korean women. The experimental group wore a near-infrared ray abdominal belt for the duration of one menstrual cycle until the end of the menstrual period, while the control group used hot packs. The level of menstrual pain, menstrual pain duration, and pain medicine use were measured. The menstrual pain, average menstrual pain duration, and use of analgesics were reduced in the near-infrared rays group. The results of this study indicate that the near-infrared ray LED belt was effective in reducing menstrual pain, menstrual pain duration compared to the use of analgesics in Korean women with dysmenorrhea. Therefore, near-infrared rays may be used to relieve menstrual pain and improve the quality of life of women with dysmenorrhea in Korea. © 2017 John Wiley & Sons Australia, Ltd.

  14. The Effect of Aromatherapy Abdominal Massage on Alleviating Menstrual Pain in Nursing Students: A Prospective Randomized Cross-Over Study

    Directory of Open Access Journals (Sweden)

    Tyseer M. F. Marzouk

    2013-01-01

    Full Text Available Dysmenorrhea is a common cause of sickness absenteeism from both classes and work. This study investigated the effect of aromatherapy massage on a group of nursing students who are suffering of primary dysmenorrhea. A randomized blind clinical trial of crossover design was used. In the first treatment phase, group 1 ( received aromatherapy abdominal massage once daily for seven days prior to menstruation using the essential oils (cinnamon, clove, rose, and lavender in a base of almond oil. Group 2 ( received the same intervention but with placebo oil (almond oil. In the second treatment phase, the two groups switched to alternate regimen. Level and duration of pain and the amount of menstrual bleeding were evaluated at the baseline and after each treatment phase. During both treatment phases, the level and duration of menstrual pain and the amount of menstrual bleeding were significantly lower in the aromatherapy group than in the placebo group. These results suggests that aromatherapy is effective in alleviating menstrual pain, its duration and excessive menstrual bleeding. Aromatherapy can be provided as a nonpharmacological pain relief measure and as a part of nursing care given to girls suffering of dysmenorrhea, or excessive menstrual bleeding.

  15. [Application of TB type thermal balloon endometrial ablation for the treatment of abnormal uterine bleeding].

    Science.gov (United States)

    Wang, W; Zhai, Y; Zhang, Z H; Li, Y; Zhang, Z Y

    2016-11-08

    Objective: To investigate the clinical efficacy, safety and promotion value of TB type thermal balloon endometrial ablation in the treatment of abnormal uterine bleeding. Methods: Fourty three patients who had received TB type endometrial ablation system for treatment of abnormal uterine bleeding from January, 2015 to January, 2016 in theDepartment of gynecology, Beijing Chaoyang Hospital were enrolled in this study. The intra-operative and post-operative complications and improvement of abnormal uterine bleeding and dysmenorrhea were observed. Results: There were nointra-operative complication occurred, such as uterine perforation, massive hemorrhage or surrounding organ damage. At 6 months after operation, 32 patients developed amenorrhea, 6 developed menstrual spotting, 3 developed menstruation with a small volume and 1 had a normal menstruation. No menstruation with an increased volume occurred. The occurrence of amenorrhea was 76.19% and the response rate was 97.62%.At 6 months after operation, 1 case had no response, 2 cases had partial response and 11 cases had complete response among the 14 cases of pre-operative dysmenorrhea; only 3 cases still had anemia among the 23 cases of pre-operative anemia. Compared with before treatment, patients with dysmenorrhea and anemia both significantly reduced with a statistically significant difference(P<0.01). Conclusion: TB type thermal balloon endometrial ablation has a significant efficacy with high safety for the treatment of abnormal uterine bleeding, which could have clinical promotion practice.

  16. Premenstrual Symptoms in Dysmenorrheic College Students: Prevalence and Relation to Vitamin D and Parathyroid Hormone Levels

    Directory of Open Access Journals (Sweden)

    Bayan A. Obeidat

    2012-11-01

    Full Text Available Objectives: To determine the prevalence of premenstrual symptoms (PMS due to primary dysmenorrhea among a sample of university female students, and to explore possible association with vitamin D and parathyroid (PTH levels, as well as frequency of consumption of dairy products. Design: A cross-sectional study. Setting: One Jordanian university. Subjects: A total of 177 female students aged between 18 and 24 years who experienced primary dysmenorrhea participated in the study and completed a self administered questionnaire to collect information concerning demographics, menstruation- related information, associated specified premenstrual symptoms, and consumption of dairy products. Plasma 25-hydroxyvitamin vitamin D level and intact parathyroid hormone level were measured. Results: Of the 177 participants 91.5% had two or more symptoms among which fatigue, mood swings, anxiety, abdominal bloating, and depression were the most prevalent symptoms. There was no evident association between presence of symptoms and vitamin D status, PTH level or dairy products consumption. Headaches and social withdrawal were significantly lower in those women who consumed high amounts of dairy products. Conclusion: Premenstrual symptoms are very common in young women with primary dysmenorrhea. PMS has no relation to levels of vitamin D, parathyroid hormone or dairy products consumption. Headache and social withdrawal may be affected by dairy product consumption.

  17. Effect of mifepristone on the expression of β-endorphin the ectopic focus of adenomyosis%米非司酮对子宫腺肌病异位病灶组织β-内啡肽表达的影响

    Institute of Scientific and Technical Information of China (English)

    王绍光; 姜学强

    2011-01-01

    目的 探讨米非司酮对子宫腺肌病异位病灶组织B-内啡肽表达的影响及其与痛经的关系.方法 应用免疫组化法检测子宫腺肌病异位病灶组织中β-内啡肽的表达.结果 轻度痛经组异位内膜组织β-内啡肽在增生期和分泌期的表达水平均高于中度痛经组(t=2.672、2.711,均P<0.05),中度痛经组异位内膜组织β-内啡肽在增生期和分泌期的表达水平均高于重度痛经组(t=2.341、2.365,均P<0.05).米非司酮治疗后,子宫腺肌病异位内膜组织β-内啡肽在增生期和分泌期的表达均高于子宫腺肌病对照组(t=2.478、2.356,均P<0.05),但均低于正常子宫内膜(t=2.123、2.233,均P<0.05).结论 子宫腺肌病异位病灶中β-内啡肽的表达随着痛经程度的加重而下降,米非司酮可以升调β-内啡肽,缓解痛经.%Objective To investigate the effect of mifepristone on the expression of β-endorphin in the ectopic focus of adenomyosis.Methods The expression of β-endorphin was measured by the immunochemistry method.Results During proliferative phase and secretory phase,the β-endorphin of mild dysmenorrhea were higher than that of midrange dysmenorrhea(t=2.672,2.711,all P<0.05),the β-endorphin of midrange dysmenorrhea was higher than that of severe dysmenorrhea(t=2.341,2.365,all P<0.05),the difference was significant.After being cured by mifepfistone,the expression of β-endorphin in the ectopic focus of adenomyosis was higher than that of control group (t=2.478,2.356,all P<0.05),still lower than that of normal endometrial tissue,(t=2.123,2.233,all P<0.05),the difference was significant.Conclusion The expression of β-endorphin in the ectopic focus of adenomyosis decreased significandy accompanied with the aggravation of the dysmenorrhea,and the mifepfistone could upregulate the β-endorphin and relieve the dysmenorrhea.

  18. Effects of Letrozole Compared with Danazol on Patients with Confirmed Endometriosis: A Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Navid Koleini

    2010-01-01

    Full Text Available Background: Letrozole is an aromatase inhibitor which can decrease estrogen production inperipheral tissues and endometriosis. Danazol, as an androgen, inhibits estrogen production inovaries and recently has been introduced as an aromatase inhibitor. This study was designed tocompare the effects of Danazol with Letrozole on endometriosis symptom relief.Materials and Methods: This study was a randomized clinical trial in which 105 patients withconfirmed endometriosis were randomly assigned to one of three groups. Group 1 received Letrozoletablets (2.5 mg/day, calcium (1000 mg/day and vitamin D (800 IU/day. Group 2 received Danazoltablets (600 mg/day, calcium (1000 mg/day and vitamin D (800 IU/day. Group 3 (placebo groupwere assigned to take two calcium tablets daily (500 mg/tablet and vitamin D (800 IU/day. Pelvicpain, dysmenorrhea and dyspareunia were assessed in participants at baseline and monthly duringthe study for a total of six months. Data were analyzed via SPSS version 15 software with Freidmanand Wilcoxon tests.Results: Mean age in three groups has no significant difference. Of the 105 participants who wereenrolled in this study, 38 patients were assigned to group 1 (Letrozole group, 37 patients in group 2(Danazol group and 31 patients were placed in group 3 (placebo group. This study showed that themean scores for chronic pelvic pain, dysmenorrhea and dyspareunia for the Letrozole group wereless than the Danazol and placebo groups.Conclusion: This study showed that Letrozole can be more effective than Danazol for reducingchronic pelvic pain, dyspareunia and dysmenorrhea in patients suffering from recurrent endometriosis(Registeration Number: IRCT138812043414N1.

  19. Laparoscopic resection versus myolysis in the management of symptomatic uterine adenomyosis: alternatives to conventional treatment

    Directory of Open Access Journals (Sweden)

    Wachyu Hadisaputra

    2006-03-01

    Full Text Available Effective therapy preserving reproductive function in adenomyosis is warranted. From June 2003 to June 2004, patients diagnosed as having adenomyosis by transvaginal ultrasound and had symptoms of menorrhagia, dysmenorrhea, and pelvic pain were randomly allocated to either receive laparoscopic resection or myolysis. GnRH analog was given for 3 cycles after surgery. Within 6 months, symptoms were evaluated using questionnaires and at the end of follow up, adenomyosis volume was assessed by transvaginal ultra-sound. There were 20 patients included, 10 patients had resection and the rest underwent myolysis. Both procedures did not yield sig-nificant complications. Subjective evaluation by questionnaires was done in all patients. Three patients could not be evaluated objec-tively by transvaginal ultrasound, 2 patients resigned and 1 was pregnant. There was no significant difference in menorrhagia and dysmenorrhea reduction score between the 2 groups (p=0.399 and 0.213, respectively. In both groups, dysmenorrhea was reduced significantly after treatment. No significant statistical difference was found in median adenomyosis volume increment (p=0.630 be-tween the resection (median=+15.35% (-100-159} and myolysis groups (median=+48.43% (-100-553. Five patients were pregnant, 3 from the resection group and 2 from the myolysis group. Uterine rupture was found in 1 patient (from the myolysis group at the age of 8 months of pregnancy. The effectiveness of laparoscopic adenomyosis resection was not significantly different compared with lapa-rascopic myolysis as an alternative conservative surgery in treating symptomatic adenomyosis. Myolysis was not recommended for women who wish to be pregnant. (Med J Indones 2006; 15:9-17Keywords: laparascopy, resection, myolysis, conservative surgery, symptomatic adenomyosis

  20. Effect Of Relaxation Education, Based on Theory of planned behavior On students’ painful dismenorrhea

    Directory of Open Access Journals (Sweden)

    Zeinab Jalambadani

    2015-10-01

    Full Text Available Background and Aim: Dysmenorrhea is one of the most common problems in females. “Theory of Planned Behavior” is one of the important theories that explains the main process of adopting health behaviors. The present study assessed applying “ the Theory of Planned Behavior in relaxation training regarding the  severity and duration of painful dysmenorrhea in Mashhad girl students. Materials and Methods: In this Semi-experimental study, 160  first year intermediate students of Mashhad city who suffered from dysmenorrhea were assessed.They had been randomly selected from 5 girl high- schools in the 6th educational district. They were divided into equal groups  “case” and “control”. Intervention was made in four sessions. The requisite  data was gathered by means of  a researcher designed questionnaire before  and 3 months after the education of the students. Finally, the obtained data was fed into SPSS software (v:16 using statistical  tests including   Wilcoxon, Mann-Whitney, Independent T-test, Paired T and X2. Results: After educational intervention, mean level of knowledge, attitude, perceived behavioral control, and willed performance of relaxation techniques significantly increased  in the case group (P<0.05. These changes were not significant in the control group. Besides, no statistically significant difference in subjective norms was observed between the two groups after intervention. Meditation education group was increased significantly (P<0.05. Conclusion: Education of relaxation base on the Theory of Planned Behavior is effective in reduced pain intensity and its duration.

  1. [Endocrino-gynecologic problems of the female adolescent].

    Science.gov (United States)

    Sirpresi, S; Antoniazzi, F; Costantini, E; Zamboni, G; Tatò, L

    1996-01-01

    Adolescence is usually defined as the period of rapid physical and psychological growth and development occurring during the second decade of life. After the introduction about the physiology of puberty and menstrual cycle, the major problems in female adolescents are discussed: delayed puberty, hypo and hypergonadotropic hypogonadism, causes of primary and secondary amenorrhea, menstrual irregularity, dysfunctional uterine bleeding, dysmenorrhea, breast disorders, hirsutism, acne. Finally, adolescent pregnancy prevention and contraception are discussed. The Authors want to stress the importance of the endocrinological and gynaecological disorders in female adolescents and their impact on the psychological and emotional development at this very delicate age.

  2. Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men.

    Science.gov (United States)

    Giamberardino, M A; Berkley, K J; Iezzi, S; de Bigontina, P; Vecchiet, L

    1997-06-01

    Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at matched intervals. Thresholds of the three tissues were measured four times during the course of one menstrual cycle at four sites. Two of the sites were on the abdomen within the uterine viscerotome (abdomen-rectus abdominis, left and right) and two were outside it on the limbs (leg-quadriceps, arm-deltoid). Calculated from the beginning of menstruation (day 0), the menstrual phases studied were menstrual (days 2-6), periovulatory (days 12-16), luteal (days 17-22) and premenstrual (days 25-28). Spontaneous pain associated with menstruation was measured from diary estimates on a VAS scale. Whereas the highest thresholds always occurred in the luteal phase regardless of segmental site or stimulus depth, the lowest thresholds occurred in the periovulatory stage for skin, whereas those for muscle/subcutis occurred perimenstrually. Dysmenorrhea accentuated the impact of menstrual phase. For non-dysmenorrheic women menstrual trends were significant only in abdominal muscle and subcutis, but for dysmenorrheic women the trends were also significant in abdominal skin and in limb muscle and subcutis. Dysmenorrhea also lowered thresholds mainly in muscle and sometimes in subcutis, but never in skin, with the greatest hyperalgesic effects in left abdominis muscle. Abdominal sites were more vulnerable to menstrual influences than limb sites. Muscle thresholds, but not skin or subcutis thresholds, were significantly lower in abdomen than in limbs, particularly in dysmenorrheic women. The amount of abdominal muscle hyperalgesia correlated significantly with the amount of spontaneous menstrual pain. Only minor sex differences were observed for pain thresholds of the

  3. A case of parasitic myoma 4 years after laparoscopic myomectomy

    Directory of Open Access Journals (Sweden)

    Osman Temizkan

    2014-01-01

    Full Text Available We present a case of parasitic myoma complaining of abdominal pain, constipation, dyspareunia and dysmenorrhea 4 years after laparoscopic myomectomy. We performed laparoscopic myomectomy for multiple parasitic myomas. Three myomas were very firmly attached to bowel and mesentery. Parasitic myoma after laparoscopic surgery is very rare condition there are almost 35 cases in the literature. It is related with variable symptoms or can be asymptomatic. Laparoscopic surgeons should be aware of this situation, and further investigation should be made in case of suspicion. Surgery for parasitic myomas can be difficult in case of bowel and mesentery involvement and patient should be informed about the extensive surgery.

  4. 妇科常用中药介绍%Introducing common gynecological medicine

    Institute of Scientific and Technical Information of China (English)

    刘宏

    2013-01-01

    对用于治疗痛经、闭经、癥瘕,治疗崩漏证,治疗产后瘀阻腹痛及恶露不绝证,治疗产后虚热证等妇科疾病的中药归纳介绍。%The TCM was summarized and introduced, which for treating dysmenorrhea, amenorrhea, Zhengjia, metrorrhagia, postpartum blood stagnation abdominal pain, lochia must not, postpartum hot syndrome and other gynecological diseases.

  5. Effect of Surgical Removal of Endometriomas on Cyclic and Non-cyclic Pelvic Pain

    Directory of Open Access Journals (Sweden)

    Murat Api

    2015-07-01

    Full Text Available Background: Endometriosis is a complex disease with a spectrum of pain symptoms from mild dysmenorrhea to debilitating pelvic pain. There is no concrete evidence in the literature whether endometriotic cyst per se, causes pain spectrum related to the disease. The aim of the present study was to evaluate the effect of surgical removal of endometriomas on pain symptoms. Materials and Methods: In this prospective, observational, before-after study, which was conducted between March 2012 and January 2013 in Training and Research Hospital,Adana, Turkey, a total of 23 patients including 16 sexually active and 7 virgin symptomatic women were questioned for non-cyclic pelvic pain (NCPP, intensity of the NCPP, presence of cyclic dysmenorrhea, and dyspareunia before and after the endometrioma operation. Participants who were sonographically diagnosed and later pathologically confirmed as having endometrioma without sign and symptoms of deep infiltrative endometriosis (DIE were also questioned for pain symptoms before and after the laparoscopic removal of cyst wall. Patients with intraabdominal adhesions, history of pelvic inflammatory disease, and pathological diagnosis other than endometrioma were excluded. No ancillary procedures were applied for pain management, but if pain was present, pelvic peritoneal endometriotic lesions were ablated beside the removal of ovarian endometriotic cysts. Results: Out of 23 cases with endometrioma, 91 and 78% reported to have NCPP and dysmenorrhea, respectively, before the operation, while 60 and 48%, respectively, after the operation (McNemar’s test, P=0.016 for both figures. Among the sexually active cases, 31% (5/16 had dyspareunia before the operation and only 1 case reported the pain relief after the operation (McNemar’s test, P=1. Intensity of NCPP were reported to be none (8.7%, moderate (21.7%, severe (56.5% and unbearable (13% before the operation and decreased to none (43.5%, mild (43.5%, moderate (4

  6. The Clinical Cases of Moxibustion Therapy%艾灸疗法验案举偶

    Institute of Scientific and Technical Information of China (English)

    陈慧

    2013-01-01

    Moxibustion set lement, the float is Yang; can go three yin and permeability of the classics; can dampness and cold, from the il s and in addition to chronic il ness. Moxibustion treat corns, beriberi, dysmenorrhea, premenstrual pain, curative ef ect is bet er.%艾灸可以沉降而纳诸浮越之阳;可以走三阴而透诸经;可以祛湿散寒,起沉疴而除痼疾。用艾灸治疗鸡眼、脚气、痛经、经前腰痛,疗效较佳。

  7. Severe Hemoperitoneum Following Rupture of Uterine Diverticulum due to Pregnancy: a Case Report

    Directory of Open Access Journals (Sweden)

    Yaghmaei Minoo

    2009-06-01

    Full Text Available Uterovaginal malformations, occur in 0.16% of women and contribute to the problems of infertility, recurrent pregnancy loss, dysmenorrhea, dyspareunia, amenorrhea and a poor outcome in pregnancy. True diverticulum is an exceedingly rare anomaly and is like a tubular formation connected to uterine cavity that ends in a cul-de sac and It is not classified as any of mullerian duct anomalies. In this article a case of uterine diverticulum rupture due to pregnancy in a 19 years old woman with nausea, vomiting and abdominal pain is reported. Although rare, in complicated pregnancy we should think to genital tract anomalies.

  8. Iatrogenic Uterine Diverticulum in Pregnancy After Robotic-assisted Myomectomy.

    Science.gov (United States)

    DeStephano, Christopher C; Jernigan, Amelia M; Szymanski, Linda M

    2015-01-01

    Uterine diverticula are rare outpouchings of the uterus associated with abnormal uterine bleeding, pelvic pain, dysmenorrhea, and adverse obstetric events. At the time of cesarean delivery at 36 5/7 weeks' gestation during the patient's first pregnancy and 36 6/7 weeks during the second pregnancy, a fundal iatrogenic uterine diverticulum at the site of a prior robotic-assisted myomectomy was noted. The outpouching communicated with the endometrial cavity and was extremely attenuated, palpably 2 to 3 mm thick. Further research is needed to determine the incidence of iatrogenic uterine diverticulum after robotic myomectomy and whether these malformations increase the risk of adverse obstetric outcomes.

  9. Imaging diagnosis of accessory and cavitated uterine mass, a rare mullerian anomaly

    Directory of Open Access Journals (Sweden)

    Nishchint Jain

    2014-01-01

    Full Text Available Accessory and Cavitated Uterine Mass (ACUM is a rare form of developmental Mullerian anomaly seen in young females, which presents as chronic recurrent pelvic pain and severe dysmenorrhea. It is an accessory cavity lying within an otherwise normal uterus. It is lined by functional endometrium and surrounded by myometrium-like smooth muscle cells; hence, it bears striking macroscopic and microscopic resemblance to the uterus. Hysterosalpingography (HSG, Ultrasonography (USG, and Magnetic Resonance Imaging (MRI form the mainstay of diagnostic imaging. The entity is often under diagnosed; therefore, a high index of suspicion combined with HSG and MRI imaging can help in making an accurate diagnosis.

  10. Two-dimensional power Doppler-three-dimensional ultrasound imaging of a cesarean section dehiscence with utero-peritoneal fistula: a case report

    Directory of Open Access Journals (Sweden)

    Royo Pedro

    2009-01-01

    Full Text Available Abstract Introduction An imaging diagnosis after an iterative cesarean delivery is reviewed demonstrating a fine ultrasound-pathologic correlation. Case presentation A 33-year-old woman (G3, P3 presented referring intense dysmenorrhea and intermenstrual spotting since her third cesarean delivery, 1 year before. A cesarean section dehiscence with utero-peritoneal fistula was diagnosed by transvaginal ultrasound. Conclusion We can conclude that transvaginal two-dimensional power Doppler and three-dimensional ultrasound are highly accurate in detecting cesarean section dehiscence and uterine fistula.

  11. Acute abdomen in a case with noncommunicating rudimentary horn and unicornuate uterus.

    Science.gov (United States)

    Atmaca, Rusen; Germen, Aysegul Tezcan; Burak, Feza; Kafkasli, Ayse

    2005-01-01

    Unicornuate uterus with a rudimentary horn is the rarest congenital anatomic anomaly of the female genital system, causing many obstetrical and gynecologic complications. The frequency of this pathology is approximately 1/100 000. A rudimentary horn usually develops following insufficient development of mullerian ducts. These patients present with dysmenorrhea, dyspareunia, and chronic pelvic pain because of endometriosis and rarely with acute abdominal symptoms following distention and torsion of the noncommunicating rudimentary horn. The case of a patient referred for acute abdomen after distention of a noncommunicating rudimentary horn is presented herein.

  12. Super Infection of An Ovarian Dermoid Cyst with Actinomyces in An Infertile Woman

    Directory of Open Access Journals (Sweden)

    Saghar Salehpour

    2013-01-01

    Full Text Available We present super infection of an ovarian dermoid cyst with actinomyces in an infertile patient.This is a case-report study for evaluation a couple with male factor infertility, who was a goodcandidate for intracytoplasmic sperm injection (ICSI, while a 10 cm dermoid cyst was foundin the woman’s right ovary. Patient complained of pelvic pain, intermittent fever, dysmenorrhea,and dyspareunia. The cyst was extracted using laparoscopy, whilst in histopathologicalexamination, an actinomycosis super infection was reported. Actinomyc super infection of anovarian dermoid cyst is a very rare incident which can also occur in women with no history ofintrauterine device (IUD usage or previous fertility.

  13. Super infection of an ovarian dermoid cyst with actinomyces in an infertile woman.

    Science.gov (United States)

    Salehpour, Saghar; Akbari Sene, Azadeh

    2013-07-01

    We present super infection of an ovarian dermoid cyst with actinomyces in an infertile patient. This is a case-report study for evaluation a couple with male factor infertility, who was a good candidate for intracytoplasmic sperm injection (ICSI), while a 10 cm dermoid cyst was found in the woman's right ovary. Patient complained of pelvic pain, intermittent fever, dysmenorrhea, and dyspareunia. The cyst was extracted using laparoscopy, whilst in histopathological examination, an actinomycosis super infection was reported. Actinomyc super infection of an ovarian dermoid cyst is a very rare incident which can also occur in women with no history of intrauterine device (IUD) usage or previous fertility.

  14. Prescott tests of equality in binary data under a three-treatment three-period crossover design.

    Science.gov (United States)

    Zhu, Lixia; Lui, Kung-Jong

    2016-12-09

    Three test procedures accounting for patients with tied responses based on Prescott's ideas are developed for comparing three treatments under a three-period crossover trial in binary data. Monte Carlo simulation is employed to evaluate the performance of these test procedures in a variety of situations. The test procedures proposed here are noted to have power larger than those procedures, which utilize only those patients with un-tied responses. The data taken from a three-period crossover trial comparing two different doses of an analgesic with placebo for the relief of primary dysmenorrhea are used to illustrate the use of the test procedures developed here.

  15. 中医二期疗法治疗子宫腺肌病痛经120例

    Institute of Scientific and Technical Information of China (English)

    王妍; 魏绍斌; 魏少奔

    2015-01-01

    Objective:To observe the clinical effection of treatment according to menstrual and non-menstrual for dysmenorrhea due to adenomyosis.Methods:120 patients with adenomyosis were collected and given the traditional treatment according to menstrual and non-menstrual. The patients took the decoction of SiNi and JinLingZi and ShiXiao powder and DuYiWei capsules during menstrual. The patients took the decoction of PuQiaoXiaoLuo and ShiXiao powder and NeiYiKangFu tablet anf FuAnNing suppository during non-menstrual.The changes of the degree and duration of dysmenorrhea were observed. Results:The degree and duration of dysmenorrhea after treatment were significantly reduced(P<0.05).Conclusion:The treatment of adenomyosis according to menstrual and non- menstrual can effectively alleviate dysmenorrhea. It is worthy of popularization and application.%目的:观察中医二期疗法治疗子宫腺肌病痛经的临床疗效。方法:120例给予中医二期疗法治疗(经期服用汤剂四逆金铃失笑散加减、中成药独一味胶囊,非经期服用汤剂蒲翘消瘰失笑散加减、中成药内异康复片、妇安宁栓直肠给药),观察治疗前后痛经程度及持续时间的变化。结果:中医二期疗法能使经行腹痛疼痛程度改善及经行腹痛疼痛持续时间缩短(P<0.05)。结论:中医二期疗法治疗子宫腺肌病痛经疗效确切。

  16. Super Infection of An Ovarian Dermoid Cyst with Actinomyces in An Infertile Woman

    Science.gov (United States)

    Salehpour, Saghar; Akbari Sene, Azadeh

    2013-01-01

    We present super infection of an ovarian dermoid cyst with actinomyces in an infertile patient. This is a case-report study for evaluation a couple with male factor infertility, who was a good candidate for intracytoplasmic sperm injection (ICSI), while a 10 cm dermoid cyst was found in the woman’s right ovary. Patient complained of pelvic pain, intermittent fever, dysmenorrhea, and dyspareunia. The cyst was extracted using laparoscopy, whilst in histopathological examination, an actinomycosis super infection was reported. Actinomyc super infection of an ovarian dermoid cyst is a very rare incident which can also occur in women with no history of intrauterine device (IUD) usage or previous fertility. PMID:24520476

  17. Hypovolemic shock due to giant uterus leiomyoma detachment.

    Science.gov (United States)

    Galani, P; Kapetanakis, S; Papadopoulos, C; Dimitrakopoulou, G; Kosma, L; Lafoyianni, S; Dimitrakova, E; Papathanasiou, J; Fiska, A

    2010-01-01

    Uterine leiomyoma (UL) is the most common benign gynecologic tumor of the reproductive age females. It is symptomatic only in 25% of the patients causing dysmenorrhea, menorrhagia or anemia. In some patients it occurs just as a palpable abdominal mass. In this study, we report a 50-year-old woman with a giant mass, attached to the uterus, which was detached and therefore led to shock due to major hemorrhage. Surgical removal of both the mass and the uterus confirmed the diagnosis of a pedunculated uterine leiomyoma.

  18. Deep endometriosis of the colon.

    Science.gov (United States)

    Ropacka-Lesiak, Mariola; Świder-Musielak, Joanna; Wójcicka, Małgorzata; Łyczywek, Anna; Skrzypek, Maciej; Waliszewski, Wojciech

    2013-01-01

    The article presents a case of deep intestinal endometriosis in a 27-year-old woman who complained of dysmenorrhea and infertility. The diagnostic process included ultrasonography as well as colonoscopy, barium enema and CT imaging. Because of the presence of two distant changes which involved nearly the full thickness of the rectal wall and the major part of its circumference, the decision to perform an anterior rectal resection with a simultaneous retroperitoneal colorectostomy was made. The Knight technique was implemented. The surgery involved the anterior rectal resection, the transverse rectal stump closure by use of a stapling device (TA50), and the creation of colorectal circular anastomosis with the CEEA 31 stapler.

  19. Postoperative Levonorgestrel-Releasing Intrauterine System Insertion After Gonadotropin-Releasing Hormone Agonist Treatment for Preventing Endometriotic Cyst Recurrence: A Prospective Observational Study.

    Science.gov (United States)

    Kim, Min Kyoung; Chon, Seung Joo; Lee, Jae Hoon; Yun, Bo Hyon; Cho, SiHyun; Choi, Young Sik; Lee, Byung Seok; Seo, Seok Kyo

    2017-01-01

    The aim of this study was to evaluate the effectiveness of postoperative levonorgestrel-releasing intrauterine system (LNG-IUS) insertion after gonadotropin-releasing hormone agonist (GnRH-a) treatment for preventing endometriotic cyst recurrence. The LNG-IUS was applied to 28 women who had undergone surgery for endometriosis followed by 6 cycles of GnRH-a treatment. Clinical characteristics, endometriosis recurrence, and adverse effects were analyzed. Student t test was performed for analysis. Before surgery, 20 (71.4%) patients had dysmenorrhea, and the mean pain score (visual analog scale [VAS]) was 4.26. The numbers of women diagnosed with stage III endometriosis and stage IV endometriosis were 15 (53.6%) and 13 (46.4%), respectively, according to the revised American Fertility Society scoring system. The mean cancer antigen 125 levels and VAS scores were significantly lower after treatment than before treatment (11.61 vs 75.66 U/mL, P < .0001 and 0.50 vs 4.26 U/mL, P < .0001, respectively). Of the 28 patients, 13 (46.4%) simultaneously had adenomyosis, and 2 (7.1%) underwent LNG-IUS removal because of unresolved vaginal bleeding and dysmenorrhea. Recurrence was noted in 2 (7.1%) women. Postoperative LNG-IUS insertion after GnRH-a treatment is an effective approach for preventing endometriotic cyst recurrence, especially in women who do not desire to conceive.

  20. Menstrual abnormalities in school going girls - are they related to dietary and exercise pattern?

    Science.gov (United States)

    Vani K, Rupa; K S, Veena; L, Subitha; Kumar V R, Hemanth; A, Bupathy

    2013-11-01

    Adolescence is the transitional phase of physical and mental development between childhood and adulthood and is characterized by immense hormonal changes.75% of girls experience some problems associated with menstruation. We tried to find out the prevalence of menstrual abnormalities in school going girls in Pondicherry and their association with dietary and exercise habits. A cross-sectional questionnaire based study was conducted in adolescent girls who attained menarche in four secondary schools of Pondicherry, India. All students who attained menarche and willing to participate in the study were invited to answer the questionnaire, which dealt with anthropometric data, socioeconomic data, menstrual history, and diet and exercise pattern. Chi-square test and Fisher's exact test was used to compare the dietary and exercise patterns among students having menstrual abnormalities and those who do not have menstrual abnormalities. A total of 853 students participated in the study. Dysmenorrhea and premenstrual symptoms were the most frequent problems encountered. Premenstrual symptoms were significantly more common among girls who were overweight, in girls who were eating junk food regularly, in girls who were eating less food (dieting) in order to lose weight and in those who were not doing regular physical activity. Dysmenorrhea was significantly more common in the girls who were dieting to lose weight. Passage of clots was also significantly high in the girls who were dieting. Lifestyle modifications like regular physical activity, decreasing the intake of junk food and promoting healthy eating habits should be emphasised in school health education programs to improve their menstrual health.

  1. Epithelial-to-mesenchymal transition in the development of adenomyosis

    Directory of Open Access Journals (Sweden)

    Ben-Shian Huang

    2015-08-01

    Full Text Available Adenomyosis is a hormone-related disease that affects 10–66% of women, and women with this disorder suffer from menorrhagia, dysmenorrhea, pelvic pain, abnormal uterine bleeding, and/or infertility. Regarding the etiology of the disease, the current trend of thought is that adenomyosis or adenomyoma results as a down-growth and invagination of the endometrial basalis into the adjacent myometrium after disruption of the normally intact boundary between the two. The eutopic endometrium of adenomyosis presents invasive characteristics, including increased angiogenesis and proliferation, decreased apoptosis, induction of the local production of estrogens, induction of progesterone resistance, and impaired cytokine expression, and these changes enhance the ability of the endometrium to infiltrate the junctional zone myometrium and the growth of ectopic tissue. Hysterectomy is the major strategy to relieve secondary dysmenorrhea caused by adenomyosis. However, fertility and uterine preservation are compromised by such treatment. The traditional pharmacological therapies for adenomyosis are primarily aimed at the suppression of endogenous estrogen production, but the results are not satisfactory. Thus, there is an urgent need to develop novel treatment strategies for adenomyosis. There has been evidence that indicates that the estrogen-induced epithelial–mesenchymal transition (EMT may play a role in the development of adenomyosis. In this article, we will concentrate on the estrogen-induced EMT in the pathogenesis of adenomyosis.

  2. Reduction in Endometrioma Size with Three Months of Aromatase Inhibition and Progestin Add-Back.

    Science.gov (United States)

    Agarwal, Sanjay K; Foster, Warren G

    2015-01-01

    The purpose of this study was to assess the impact of 3 months of aromatase inhibition together with progestin add-back on ovarian endometrioma size. This prospective cohort study was performed at University Medical Center (UC San Diego). Women trying to conceive were excluded. After informed consent, all women were treated with the aromatase inhibitor letrozole (5 mg/d) with norethindrone acetate (5 mg/d) add-back for 3 months. Pre- and posttreatment assessments of endometrioma sizes were performed by ultrasound. The impact of treatment on pain was determined using the patient assessed endpoints of the Biberoglu and Behrman scale. These included assessing dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain each on a scale from 0 to 3. The primary endpoint of this study was the change in ultrasound documented endometrioma size. Fourteen endometriomas in 8 consecutive women were treated for 3 m. Mean endometrioma diameter decreased 50% from 4.6 ± 1.6 cm to 2.3 ± 1.6 cm (mean ± SD). This represents a 75% decrease in endometrioma volume. Endometriosis symptoms of dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain also improved with treatment. In conclusion, a 3-month course of high dose aromatase inhibition with progestin add-back significantly reduces ovarian endometrioma size and warrants further investigation.

  3. Optimal management of chronic cyclical pelvic pain: an evidence-based and pragmatic approach

    Directory of Open Access Journals (Sweden)

    Ha Ryun Won

    2010-08-01

    Full Text Available Ha Ryun Won, Jason AbbottDepartment of Endo-Gynecology, Royal Hospital for Women, Sydney, New South Wales, AustraliaAbstract: This article reviews the literature on management of chronic cyclical pelvic pain (CCPP. Electronic resources including Medline, PubMed, CINAHL, The Cochrane Library, Current Contents, and EMBASE were searched using MeSH terms including all ­subheadings and keywords: “cyclical pelvic pain”, “chronic pain”, “dysmenorrheal”, “nonmenstrual ­pelvic pain”, and “endometriosis”. There is a dearth of high-quality evidence for this common ­problem. Chronic pelvic pain affects 4%–25% of women of reproductive age. Dysmenorrhea of varying degree affects 60% of women. Endometriosis is the commonest pathologic cause of CCPP. Other gynecological causes are adenomyosis, uterine fibroids, and pelvic floor myalgia, although other systems disease such as irritable bowel syndrome or interstitial cystitis may be responsible. ­Management options range from simple to invasive, where simple medical ­treatment such as the combined oral contraceptive pill may be used as a first-line treatment prior to invasive ­management. This review outlines an approach to patients with CCPP through history, physical examination, and investigation to identify the cause(s of the pain and its optimal management.Keywords: cyclical pelvic pain, chronic pain, dysmenorrhea, nonmenstrual pelvic pain, endometriosis

  4. Effects of a Bovine Lactoferrin Formulation from Cow’s Milk on Menstrual Distress in Volunteers: A Randomized, Crossover Study

    Directory of Open Access Journals (Sweden)

    Hiroshi M. Ueno

    2016-05-01

    Full Text Available Dysmenorrhea is a highly prevalent complaint and highly undiagnosed gynecologic condition. Dairy products have a potential in the management of menstrual distress, and bovine lactoferrin can help the subjective dysphoria associated with dysmenorrhea. In the present study, we aimed to investigate the effects of a lactoferrin formulation isolated from cow’s milk on menstrual symptoms in volunteers. A double-blind, randomized, placebo-controlled, crossover study of the iron-lactoferrin complex (FeLf was performed in thirty-five healthy Japanese women. Participants received the 150 mg FeLf (per day or placebo from day ten of the luteal phase to day four of the follicular phase. The Moos Menstrual Distress Questionnaire (MDQ was measured for menstrual distress, and heart rate variability was measured as an index of autonomic nerve balance during menses. A visual analog scale for menstrual pain, and a verbal rating scale for quality of life during the first three days of menstruation were measured. The MDQ score for the automatic nervous system subscale was lower and the parasympathetic nervous system activity was greater in FeLf than in placebo for intention-to-treat or per-protocol populations. The other variables were not different between the groups. No treatment-related side effects were observed during the study. The results indicate that FeLf can provide a beneficial effect on the psychological symptoms in women affected by menstrual distress.

  5. Endometriosis in teenagers.

    Science.gov (United States)

    Sarıdoğan, Ertan

    2015-08-01

    Endometriosis affects a significant proportion of teenagers. Published studies suggest that laparoscopically confirmed endometriosis could be found in over 60% of adolescent girls undergoing laparoscopic investigation for pain, in 75% of girls with chronic pelvic pain resistant to treatment and in 70% of girls with dysmenorrhea and in approximately 50% of girls with chronic pelvic pain not necessarily resistant to treatment. Both early and advanced forms, including deep endometriosis have been reported to be present in teenagers. It has recently been claimed that deep endometriosis has its roots in teenage years. Risk factors include obstructive mullerian anomalies, family history, early menarche and early onset dysmenorrhea. Both surgical and medical treatment approaches are used for treatment in this age group, but care should be taken when treatment with GnRHa and progestins is being considered due to their potential impact on bone formation. Further studies are urgently needed to determine whether early diagnosis and treatment of teenage endometriosis lead to better long term outcomes or simply increase number of interventions without preventing progression of the disease.

  6. Inhibitory effects of active fraction and its main components of Shaofu Zhuyu decoction on uterus contraction.

    Science.gov (United States)

    Su, Shulan; Hua, Yongqing; Duan, Jin-Ao; Zhou, Wei; Shang, Erxin; Tang, Yuping

    2010-01-01

    Shaofu Zhuyu decoction is a famous formula for treating primary dysmenorrhea in China since the Qing dynasty. In this paper, the inhibitory effects of active-guided fraction and its main bioactive components of Shaofu Zhuyu decoction on a model of non-pregnant mice uterine contraction induced by oxytocin in vitro were investigated. Qualitative and quantitative chemical analyses were used to correlate the chemical composition of active fraction with the spasmolytic effects. Seven ingredients in the active fraction were identified and quantified by HPLC-DAD. Three ingredients, ferulic acid, vanillic acid, and typhaneoside, were evaluated for their effects on mice isolated uterine contraction induced by oxytocin in vitro. The ED(50) of them were 63.0 microg/ml, 57.6 microg/ml, 109.7 microg/ml, respectively. Furthermore, the inhibitory activity of the combination of these three compounds was prior to the fraction and seven compounds group. The ED(50) was 65.5 microg/ml. The data stated that ferulic acid, vanillic acid, and typhaneoside were possibly the main active components in the bioactive fraction of Shaofu Zhuyu decoction. The study also implied that Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus and justified the traditional use of the prescription for treating the uterine cramping associated dysmenorrhea.

  7. Experience of Professor LI Ying for treating menstrual pain%李颖教授治疗经行腹痛的经验

    Institute of Scientific and Technical Information of China (English)

    梁艳; 尹燕飞

    2014-01-01

    经行腹痛,亦称痛经,是妇科常见病、多发病之一。许多妇女在经期或经期前后有轻度不适,不过痛经是指经期的疼痛影响了正常的活动,并且需要药物治疗。导师治疗本病多以温胞散寒、活血化瘀为治则,自拟经验方治疗,疗效显著。%Menstrual pain also known as dysmenorrhea, is a common gynecological diseases and frequently-occurring. Many women have mild discomfort during menstruation or menstrual period before and after, and dysmenorrhea refers to menstrual pain affecting the normal activities and requires medication. According to the treatment principles of warm and cold cells, blood circulation, my mentor use the experience recipe to treat this disease, has a significant effect.

  8. 左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的研究进展%Research Progress in Levonorgestrel Intrauterine Releasing System Treating Endometriosis

    Institute of Scientific and Technical Information of China (English)

    李水莲

    2013-01-01

    左炔诺孕酮宫内缓释系统(LNG-IUS),以20 μg/d的剂量释放高效孕激素,使子宫内膜腺体萎缩,间质蜕膜样变,黏膜变薄,能有效缓解子宫内膜异位症(EMs)患者痛经、深部性交痛及慢性盆腔痛,可缩小子宫体积,减少月经量,降低保守性手术后中/重度痛经复发率.近年来,LNG-IUS用于缓解EMs和防止其复发均取得了较好效果.%Levonorgestrel intrauterine releasing system( LNG-IUS ),through releasing 20 μ g/d dose of efficient progestational hormone, making the endometrial glands atrophy, interstitial decidual change, mucous membrane thinned,can effectively relieve EMs patients dysmenorrhea, deep sexual pain and chronic pelvic pain,reduce uterine volume,reduce menstrual quantity,and reduce the moderate/severe dysmenorrhea recurrence rate of conservative surgery. In recent years, LNG-IUS has achieved good effect in relieving EMs and preventing the recurrence.

  9. 子宫内膜异位症与其他妇科良性疾病的相关性研究%Correlation between Endometriosis and Other Benign Gynecological Diseases

    Institute of Scientific and Technical Information of China (English)

    蔡柏岑; 周应芳; 石贺元

    2014-01-01

    目的:探讨子宫内膜异位症(endometriosis,EM)与其它妇科疾病的相关性,为EM诊治提供依据。方法回顾分析2005年7月~2009年6月北京大学第一临床医学院妇产科的妇科盆腔手术病例资料。对EM与妇科疾病的相关因素进行分析。结果①EM与其它妇科疾病相比,患者年龄较轻、初潮年龄较早、月经周期较短、经期较长、痛经及不孕人数较多、术中出血较多,且多合并子宫腺肌病,差异有统计学意义(P<0.05)。②痛经为EM的独立危险因素。③子宫肌瘤合并 EM者,年龄较轻、初潮年龄较早,痛经、不孕者较多;产次及人流次数较少。④子宫腺肌病合并EM者,年龄较轻、初潮年龄较早、未孕未产者较多。⑤其他子宫、卵巢、输卵管良性疾病合并EM者,痛经人数显著增多。结论①EM最常合并子宫腺肌病;②痛经为子宫内膜异位症的独立危险因素。%Objective: To determine the correlation between endometriosis and other benign gynecological diseases. Methods: A retrospective study of patients who received pelvic surgeries in Obstetric & Gynecology department of Peking University first hospital during Jul. 1,2005 to Jun. 30,2009. Identifying the related factors between endometriosis and other benign gynecological diseases. Results:(1) Compared with other gynecologic diseases,patients with endometriosis are more younger, having earlier age at menarche,shorter menstrual cycle,longer period,more dysmenorrhea,infertility and bleeding. Moreover,patients with endometriosis are more common accompanying with adenomyosis (P<0.05). (2) Multivariate logistic regression demonstrates that dysmenorrhea is the risk factor of endometriosis. (3) Compared with leiomyomas,uterine fibroids with endometriosis are younger and having earlier age at menarche,and more dysmenorrhea and infertility. (4) Compared with adenomyosis, endometriosis with adenomyosis is younger and having earlier

  10. Correlation between pelvic adhesions and pain symptoms of endometriosis%子宫内膜异位症患者盆腔粘连与疼痛的相关性

    Institute of Scientific and Technical Information of China (English)

    郝敏; 赵卫红; 王永红

    2009-01-01

    目的 探讨子宫内膜异位症(内异症)患者中盆腔粘连的发生率及其与疼痛症状的相关性. 方法 分析2003年1月至2007年12月间480例内异症患者盆腔粘连及痛经、慢性盆腔痛(CPP)、性交痛与排便痛的发生情况,评价内异症患者的盆腔粘连与疼痛症状之间的相关性.根据美国生育学会1985年修订的内异症分期标准(r-AFS)分为Ⅰ期155例,Ⅱ期33例,Ⅲ期108例,Ⅳ期184例. 结果 (1)480例内异症患者中,72.3%(347/480)存在盆腔粘连;Ⅰ期25.2%(39/155),Ⅱ期78.8%(26/33),Ⅲ期90.7%(98/108),Ⅳ期100.0%(184/184),且盆腔粘连程度与内异症的临床期别间呈正相关关系(rs=0.870,P<0.01);(2)480例内异症患者中,伴痛经者占61.0%(293/480),其中轻、中、重度痛经分别为52.2%(153/293)、26.6%(78/293)、21.2%(62/293);伴CPP者占23.8%(114/480),伴性交痛者占15.4%(74/480),伴排便痛者占7.1%(34/480);(3)卵巢粘连与痛经和CPP呈正相关关系(rs=0.367、0.267,P<0.01);子宫底后壁粘连与痛经和CPP呈正相关关系(rs=0.336、0.164,P<0.01);输卵管粘连与痛经、CPP和排便痛均呈显著正相关关系(rs=0.283、0.225、0.159, P<0.01);直肠粘连与痛经呈正相关关系(rs=0.101,P<0.05).除性交痛外,内异症患者的盆腔粘连程度与其痛经、CPP及排便痛均呈正相关关系(rs=0.470、0.273、0.132、P<0.01).结论 盆腔粘连是内异症的特征性病变,粘连部位及程度与疼痛症状密切相关.%Objective To study the incidence of pelvic adhesions in endometriosis(EM) and the relationship between pelvic adhesions and pain symptoms. Methods The incidence of pelvic adhesions, dysmenorrhea, chronic pelvic pain, dyspareunia, dyschizia in 480 patients with EM were studied retrospectively to evaluate the correlation between pelvic adhesions and the degree of pain symptoms. In accordance with the revised American Fertility Society classification (r-AFS), it was observed that 155 cases were in Stage Ⅰ,33 cases

  11. Ethnomedicine of menstruation in rural Dominica, West Indies.

    Science.gov (United States)

    Flores, Katherine E; Quinlan, Marsha B

    2014-05-14

    In Dominica, women offer dysmenorrhea, delayed menses, and menorrhagia as prevalent menstrual troubles. Dominican humoral theory considers menstruation to be "hot" such that menstrual problems are caused by the introduction of too much "cold" in the body. These conditions can be painful and may require herbal medicine. Our method finds the most culturally salient plants for these conditions-those which are of common knowledge across the population. We hypothesize that cultural agreement on ethnobotanical treatments (1) reflects their perceived ethnophysiological efficacy, and that (2) salient plants contain bioactive compounds appropriate for the menstrual conditions for which Dominicans employ the plants. Qualitative data on local explanatory models and treatment of menstrual conditions were collected using participant-observation, focus groups, and informal key informant interviews. Quantitative ethnobotanical data come from freelist (or "free-list") tasks, conducted with 54 adults. Mean salience values calculated from freelisted data reveal that the same four plants, Cinnamomum verum (synonym Cinnamomum zeylanicum) (Lauraceae), Mentha suaveolens (Lamiaceae), Pimenta racemosa (Myrtaceae) and Sphagneticola trilobata (synonym Wedelia trilobata) (Asteraceae) are used to treat dysmenorrhea and delayed menses. The only remedy reported for menorrhagia, Sphagneticola trilobata (Asteraceae), is also a treatment for dysmenorrhea and delayed menses. The Dominican humoral system views menstruation as a "hot" condition, yet these "bush medicines" are also "hot." Dominicans do not view menstruation as a problem, rather, they reckon that excess "cold" in a woman׳s menstruating body impedes menstrual function to cause problems thus requiring "hot" plants to alleviate their symptoms. A literature review revealed that all four plants contain analgesic, anti-nociceptive, and anti-inflammatory properties. Additionally, Mentha suaveolens is muscle-relaxing and anti

  12. [Clinical study of high intensity focused ultrasound ablation combined with GnRH-a and LNG-IUS for the treatment of adenomyosis].

    Science.gov (United States)

    Ye, M Z; Deng, X L; Zhu, X G; Xue, M

    2016-09-25

    Objective: To investigate the clinical effect of dysmenorrhea in patients with adenomyosis treated by high intensity focused ultrasound(HIFU)ablation combined with gonadotropin-releasing hormone agonist(GnRH-a)and levonorgestrel-releasing intrauterine system(LNG-IUS). Methods: From April 2012 to December 2015, 477 cases of adenomyosis patients with dysmenorrhea were treated by HIFU in the Third Xiangya Hospital. Among them, some patients were treated with HIFU alone, some of them were treated with HIFU combined with GnRH-a and(or)LNG-IUS, thus were classified as H group, H+G group, H+M group and H+G+M group. The improvements of clinical results were compared among the four groups and the influencing factors of HIFU treatment for adenomyosis were also analyzed. Results: During the follow-up period, the overall effective rates of the treatment decreased with time, 3 months 89.4%(345/386), 12 months 84.0%(221/263), 24 months 74.2%(98/132), and the overall recurrence rate was 12.9%(39/303). The significant difference in the curative at 3 months[H group 83.7%(170/203), H+M group 95.0%(95/100), H+G group 100.0%(43/43), H+G+M group 96.8%(30/31)], 12 months[H group 79.4%(123/155), H+M group 93.2%(69/74), H+G group 11/12, H+G+M group 15/17], and 24 months[H group 68.0%(51/75), H+M group 96.4%(27/28), H+G group 6/12, H+G+M group 15/15]after HIFU treatment and recurrence rate[H group 19.0%(29/153), H+M group 3.3%(3/90), H+G group 19.4%(6/31), H+G+M group 4.5%(1/22)]were observed among the four groups(PLNG-IUS could improve the treatment effect in relief of dysmenorrhea. Based on our results, individual treatment protocol should be selected for different patients.

  13. 子宫腺肌病118例诊疗分析%Clinical analysis of 118 cases of uterine adenomyosis

    Institute of Scientific and Technical Information of China (English)

    童德梅; 陆小玲; 石杰

    2015-01-01

    目的:探讨子宫腺肌病的发病因素、临床特征及诊疗方法.方法:收治子宫腺肌病患者118例,回顾性分析其临床资料.结果:行非手术和保留子宫手术治疗共59例,宫内放置曼月乐痛经缓解率71.42%,腺肌瘤病灶切除术后,宫内放置曼月乐痛经缓解率88.24%,而单纯腺肌瘤病灶切除,未放置曼月乐痛经缓解率64.29%.本组月经紊乱或月经过多者均改善.不孕12例中,治疗后妊娠并分娩2例(16.67%).结论:在临床上可通过综合判断提高对子宫腺肌病的诊断准确率.宫内放置曼月乐是子宫腺肌病理想的辅助治疗方法.%Objective:To explore the pathogenic factors,clinical features and treatment methods of uterine adenomyosis.Methods:118 patients with adenomyosis were selected,and the clinical data were retrospectively analyzed.Results:59 cases were given non operation treatment and retain uterine operation treatment,laying up mirena in uterine cavity,dysmenorrhea relief rate was 71.42%;after adenomyoma lesions resection,laying up mirena in uterine cavity,dysmenorrhea relief rate was 88.24% ,but the pure adenomyoma lesions resection,without mirena,dysmenorrhea relief rate was 64.29% .In this group,patients with menstrual disorders or menorrhagia were improved.In 12 cases of infertility,after treatment,2 cases(16.67%) had pregnancy and childbirth. Conclusion:In clinical practice,the comprehensive judgment can improve the accuracy of diagnosis of uterine adenomyosis.Laying up mirena in uterine cavity was an ideal auxiliary treatment for uterine adenomyosis.

  14. 探讨中药肉桂与食用桂皮的比较与鉴定分析%Comparative study and analysis of Chinese traditional medicine cassia and cinnamon

    Institute of Scientific and Technical Information of China (English)

    茹青堂

    2014-01-01

    Objective to explore the research of traditional chinese medicine cinnamon and comparison analysis and identification of cinnamon.Methods the traditional chinese medicine cassia and cinnamon compare, observe the morphological and histological, differences, and then were randomly divided into 61 cases of dysmenorrhea into two groups, 30 cases in the control group taking cinnamon, the observation group of 31 cases taking cinnamon, two groups were observed and pain relief and complications.Results the traditional chinese medicine cassia and cinnamon in morphology, microscopic characters, there is signiifcant difference, two groups of clinical effect in the treatment of dysmenorrhea, the control group the total effective rate was 53.3%, total effective rate of observation group was 83.9%, the observation group was better than the control group.Conclusion there is difference, chinese cinnamon and cinnamon do not mix, in clinical treatment, therapeutic effect on dysmenorrhea of congealing cold and blood stasis syndrome of cinnamon was obviously better than that of cinnamon, and after operation was signiifcantly lower than the control group.%目的:探讨研究中药肉桂与食用桂皮之间的比较和鉴定分析。方法将中药肉桂与食用桂皮做比较,观察其在性状、显微等方面的差异,然后将61例痛经的患者随机分为两组,对照组30例服用桂皮,观察组31例服用肉桂,观察两组的疼痛缓解情况及并发症的发生。结果中药肉桂与食用桂皮在形态、性状、显微等方面有明显差异,两组在治疗痛经的临床效果上,对照组总有效率为53.3%,观察组总有效率为83.9%,观察组明显优于对照组。结论中药肉桂与食用桂皮有较大的差异,不能混用,在临床治疗上,中药肉桂对痛经寒凝血淤证的治疗作用明显优于食用桂皮,并且并发证的发生明显低于对照组。

  15. Application analysis of levonorgestrel intrauterine device in treatment of young and middle-aged people with adenomyosis%左炔诺孕酮宫内节育器在中青年子宫腺肌症治疗中的应用分析

    Institute of Scientific and Technical Information of China (English)

    涂小娥; 刘强

    2014-01-01

    目的:探析左炔诺孕酮宫内节育系统在中青年子宫腺肌症治疗中的临床效果。方法选取我院就诊治疗子宫肌腺患者28例子宫腺肌患者,观察在放置左炔诺孕酮宫内节育器前后痛经、月经量、子宫体积、子宫内膜厚度、血清CA125、血清性激素水平的变化情况,比较治疗前后患者临床症状、激素水平的变化及不良反应。结果左炔诺孕酮宫内节育器放置12个月后,患者的痛经程度降低,子宫体积和子宫内膜厚度明显减小,CA125水平明显减低,与放置前相比差异有统计学意义(P<0.05)。结论利用左炔诺孕酮宫内节育器可明显改善子宫腺肌症中痛经、月经量等临床症状,值得临床进一步研究进而推广。%Objective To explore the clinical effects of levonorgestrel intrauterine device in the treatment of young and middle-aged people with adenomyosis.Methods Twenty-eight patients with adenomyosis treated in our hospital were selected.Changes of the patients'dysmenorrhea,menstrual blood volume,uterine volume, endometrial thickness,serum CA125 and serum sex hormone levels after placing the levonorgestrel intrauterine device were observed.The clinical symptoms,hormone level changes and adverse reactions of the patients before and after the placement of levonorgestrel intrauterine device were compared.Results After placing the levonorgestrel intrauterine device for 12 months, the patients'dysmenorrhea degree decreased,uterine volume and endometrial thickness significantly reduced, and CA125 level significantly lowered,with significant differences to those before placing (P<0.05).Conclusion The application of levonorgestrel intrauterine device can significantly improve the clinical symptoms such as dysmenorrhea and menstrual blood volume in adenomyosis,thereby worthy of further clinical study and subsequent promotion.

  16. Application analysis of levonorgestrel-releasing intrauterine device in the treatment of young and middle-aged patients with adenomyosis%左炔诺孕酮宫内节育器在中青年子宫腺肌症治疗中的应用分析

    Institute of Scientific and Technical Information of China (English)

    徐红云

    2015-01-01

    目的 探讨临床上使用左炔诺孕酮宫内节育器治疗中青年子宫腺肌症的疗效. 方法 选取2013年1月至2014年9月鄢陵县人民医院收治的24例子宫腺症患者为研究对象,于宫内置左炔诺孕酮宫内节育器,随访1年,观察记录节育器放置前和放置后4、8、12 个月时患者的月经量、痛经程度、子宫大小、子宫内膜厚度、血清CA125及性激素变化情况. 结果 连续放置1年后患者月经量显著减少、痛经程度明显减轻、子宫大小和子宫内膜厚度显著降低、CA125水平显著降低,与放置前比较差异有统计学意义( P0.05). 结论 左炔诺孕酮宫内节育可显著改善中青年子宫腺肌症患者的月经量并缓解痛经,是一种较好的治疗中青年子宫腺肌症的保守治疗手段.%Objective To investigate the clinical effect of levonorgestrel-releasing intrauterine device on young and middle-aged patients with adenomyosis .Methods Twenty-four patients with adeno-myosis from January 2013 to September 2014 were selected and treated by levonorgestrel-releasing intrau-terine device .The menstrual capacity , dysmenorrhea of the degree , uterine size , endometrial thickness , serum CA125 and serum sex hormone levels were detected before and 4 , 8 , 12 months after treatment . Results After treatment for 12 months, the menstrual capacity , dysmenorrhea of the degree , uterine size, endometrial thickness, serum CA125 were changed significantly (P0.05).Conclusions The application of levonorgestrel-releasing intrauterine device is good to im-prove the clinical symptoms such as menstrual capacity and dysmenorrhea of the degree in adenomyosis , which can be a good conservative treatment method for the treatment of young and middle-aged patients with adenomyosis .

  17. Spasmolytic and anti-inflammatory effects of Aloysia triphylla and citral, in vitro and in vivo studies.

    Science.gov (United States)

    Ponce-Monter, Héctor; Fernández-Martínez, Eduardo; Ortiz, Mario I; Ramírez-Montiel, Martha L; Cruz-Elizalde, Delia; Pérez-Hernández, Nury; Cariño-Cortés, Raquel

    2010-01-01

    Aloysia triphylla is traditionally utilized for the treatment of menstrual colic (primary dysmenorrhea) in Mexico. Citral is the main chemical component found in Aloysia triphylla leaves extract. Primary dysmenorrhea is a very frequent gynecological disorder in menstruating women, affecting 30-60% of them. It is usually treated with non-steroidal anti-inflammatory drugs (NSAIDs); although their effect is rapid, they possess many side effects. Due to these shortcomings, Mexican folk therapy is considered as a feasible alternative. The effects of the hexane extract of Aloysia triphylla and citral on uterine contractions were evaluated in vitro as well as their anti-inflammatory properties and gastric wound capabilities were assessed in vivo. The inhibitory effects on the contractions were analyzed using isolated uterus strips from estrogen primed rats. Contractions were induced by KCl 60 mM, oxytocin 10 mIU/mL, charbacol 10 µM and PGF(2α) 5 µM. The anti-inflammatory effect was assessed on carrageenan-induced rat hind paw edema model. The inhibitory concentration-50 (IC(50)) of the hexane extract of Aloysia triphylla upon each contractile response was for KCl 44.73 ± 2.48 µg/mL, oxytocin 42.16 ± 3.81 µg/mL, charbacol 41.87 ± 1.73 µg/mL and PGF(2α) 28.70 ± 2.40 µg/mL in a concentration-dependent way. The extract of Aloysia triphylla produced a significant inhibitory effect on PGF(2α)-induced contraction compared to its inhibitory actions on the others. Citral exhibited the same inhibitory effect on the contraction induced by PGF(2α). The oral administration of the extract (100-800 mg/kg) and citral (100-800 mg/kg) showed anti-inflammatory activity; furthermore, the maximal dose utilized did not produce gastric injury. These results were compared with anti-inflammatory effects and gastric damage produced by 30 mg/kg of indomethacin p.o. The spasmolytic and anti-inflammatory effects support the traditional use of Aloysia triphylla leaves in the treatment of

  18. Women's Health Among the Chumash

    Directory of Open Access Journals (Sweden)

    James D. Adams

    2006-01-01

    Full Text Available Plants were, and still are, widely used for a number of conditions affecting women in California. This article discusses traditional remedies of the Chumash for dysmenorrhea, premenstrual syndrome, feminine hygiene, heavy menstruation, urinary tract infections, parturition, lactation, infant care, menopause, sexually transmitted diseases, fertility, contraception and abortions. Many plants are presented including Artemisia douglasiana, Paeonia californica, Trichostema lanatum, Salvia apiana, Ephedra viridis, Leymus condensatus, Vitis californica, Eschscholzia californica, Rosa californica, Scirpus acutus, Anemopsis californica and Phoradendron macrophyllum. By providing the specific uses of plants for specific diseases and discussing chemistry, efficacy and safety concerns for each plant, we hope that this article gives direction to women seeking to use plants in their health care.

  19. Comparative effectiveness and impact on health-related quality of life of hysterectomy vs. levonorgestrel intra-uterine system for abnormal uterine bleeding.

    Science.gov (United States)

    Cozza, G; Pinto, A; Giovanale, V; Bianchi, P; Guarino, A; Marziani, R; Frega, A; Caserta, D

    2017-05-01

    To compare hysterectomy and levonorgestrel intra-uterine system (LNG-IUS) for the treatment of abnormal uterine bleeding (AUB) and iron deficiency anemia. Retrospective study evaluating quality of life, sexual function, satisfaction and blood hemoglobin concentration improvement in 60 pre-menopausal women treated with hysterectomy or LNG-IUS. All analysis was performed with statistical software SPSS 21.0 (SPSS Inc., Chicago, IL, USA). Despite superior control of bleeding and dysmenorrhea observed after hysterectomy, LNG-IUS showed similar impact on blood hemoglobin levels, quality of life, satisfaction and sexual function resulting more cost-effective. In the absence of contraindications, LNG-IUS should always be the first therapeutic choice for chronic AUB. Surgical treatment must be considered as an "extrema ratio".

  20. Clinical Study of Vitamin K3 Acupoint Injection In Treating Pelvic Pain

    Institute of Scientific and Technical Information of China (English)

    ZHAO Wen-jie (赵文洁); WANG Li (王莉); WENG Jian'er (翁健儿); YU Jin (俞瑾)

    2003-01-01

    @@ Pelvic pain is one of the most common symptoms in gynecologic outpatients. Primary dysmenorrhea, acute or chronic pelvic inflammatory disease, endometriosis, post-operational pelvic adhesion, blood stagnation of pelvic vein, etc., are mentioned as the often encountered causes of pelvic pain. It has been reported in the recent ten or more years that intramuscular injection of vitamin K3 (Vit K3) could relieve pain induced by smooth muscle spasm(1,2). In order to evaluate the effect of Vit K3 administered by acupoint injection in relieving pelvic pain, 180 patients were treated and observed from April 1997 to April 1999 in our hospital, and good therapeutic effect was obtained. It was reported as follows.

  1. The state of hormonal contraception today: established and emerging noncontraceptive health benefits.

    Science.gov (United States)

    Maguire, Karla; Westhoff, Carolyn

    2011-10-01

    In the 50 years since the advent of combined oral contraceptives the amount of estrogen in oral contraceptives dropped from over 100 mcg to less than 30 mcg. Many noncontraceptive health benefits have emerged that decrease mortality and improve quality of life. Some of the immediate benefits include improvement of menorrhagia and dysmenorrhea, reduction in premenstrual dysphoric disorder symptoms, and decreased acne. As an effective birth control method oral contraceptives also decrease pregnancy-related deaths by preventing pregnancy. After the reproductive years, previous use of oral contraceptives continues to be beneficial, reducing the risk of death from ovarian and endometrial cancer. All these benefits have held up over time whereas cardiovascular risks have lessened because of the decrease in oral contraceptive pill dosage. Decreased ovarian cyst formation is an example of benefit with higher-dose oral contraceptive formulations that no longer holds true with low-dose pills. Copyright © 2011 Mosby, Inc. All rights reserved.

  2. Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis.

    Science.gov (United States)

    Choi, Young Sik; Cho, Sihyun; Lim, Kyung Jin; Jeon, Young Eun; Yang, Hyo In; Lee, Kyung Eun; Heena, Kamdar; Seo, Seok Kyo; Kim, Hye Yeon; Lee, Byung Seok

    2010-12-01

    The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patients who had undergone hysterectomies for adenomyosis. Immunohistochemistry with antibodies against NGF, NGFR p75, and TrkA, was performed. The expression of NGF, NGFR p75, and TrkA in endometrium and myometrium of LNG-IUS-treated patients was significantly decreased compared to those of hormonally untreated patients. Our findings may indicate that the suppression of NGF and its receptors by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis.

  3. High-intensity focused ultrasound treatment of abnormal vaginal bleeding secondary to uterine myoma.

    Science.gov (United States)

    Lim, Jung Hyun; Chung, Dong Jin; Lim, Young Tec; Cho, Sae Hyun; Lee, Jae Mun; Hahn, Seong-Tae

    2011-03-01

    We describe the use of high-intensity focused ultrasound for acute vaginal bleeding secondary to uterine myoma in 2 young female patients. Both patients had episodes of abnormal vaginal bleeding with severe dysmenorrhea that was not efficiently controlled by medical treatment. After high-intensity focused ultrasound ablation, both vaginal bleeding control and symptom relief were achieved without postinterventional complications. The patients remained free of symptoms during 2 months of follow-up and regained normal menstruation after high-intensity focused ultrasound therapy. High-intensity focused ultrasound treatment is one of the least invasive options for dysfunctional vaginal bleeding and may be an effective and safe alternative to other procedures in women of reproductive age with abnormal vaginal bleeding secondary to uterine myoma.

  4. Safety and efficacy of Labisia pumila containing products

    Directory of Open Access Journals (Sweden)

    Muhammad Syafiq Saleh

    2016-01-01

    Full Text Available Labisia pumila is a traditional medicinal plant which has wide therapeutic application including induction of labor and treatment of dysentery, dysmenorrhea and gonorrhea. We aimed for systematic review of the efficacy andsafety of L. pumila extract or its other commercial products availabe in Malaysian market. The marketed 500 mg capsule is composed of 40 mg L. pumila, 10 mg C. caudatum extract and 450 mg excipient. The commercial products did not follow the registration guidelines of Malaysian National Pharmaceutical Control Bureau (NPCB and advertisement guidelines of Malaysian Advertisement Board. Randomized, placebo controlled clinical trials reported the safe consumpotion of L. pumila water extract on postmanoposal women. Information on the efficacy and safety of commercial products are not sufficiently available. Many unregistered products (mostly capsule form are flooded in Malaysian market without having scientific information. Consumption of those products may seriously impair the health of the people.

  5. A Case of Chronic Abdominal Neuropathic Pain and Burning after Female Genital Cutting

    Directory of Open Access Journals (Sweden)

    Vicky Hadid

    2015-01-01

    Full Text Available Introduction. Female genital cutting is prevalent in the Middle Eastern and African countries. This ritual entails not only immediate complications such as infection, pain, and haemorrhage, but also chronic ones including dysmenorrhea and dyspareunia. However, there is limited data on neuropathic pain secondary to female genital mutilation when searching the literature. Case. This case discusses a 38-year-old female with a history of infibulation who presented with a chronic burning abdominal and anterior vulvar pain including the related investigations and treatment. Discussion. This case brings to light the additional delayed complication of this ritual: sensory neuropathy. Our goal is to educate health professionals to be aware of these complications and to appropriately investigate and treat them in order to find a solution to relieve the patients’ symptoms.

  6. Estimation of the treatment effect under an incomplete block crossover design in binary data - A conditional likelihood approach.

    Science.gov (United States)

    Lui, Kung-Jong

    2015-07-15

    A random effects logistic regression model is proposed for an incomplete block crossover trial comparing three treatments when the underlying patient response is dichotomous. On the basis of the conditional distributions, the conditional maximum likelihood estimator for the relative effect between treatments and its estimated asymptotic standard error are derived. Asymptotic interval estimator and exact interval estimator are also developed. Monte Carlo simulation is used to evaluate the performance of these estimators. Both asymptotic and exact interval estimators are found to perform well in a variety of situations. When the number of patients is small, the exact interval estimator with assuring the coverage probability larger than or equal to the desired confidence level can be especially of use. The data taken from a crossover trial comparing the low and high doses of an analgesic with a placebo for the relief of pain in primary dysmenorrhea are used to illustrate the use of estimators and the potential usefulness of the incomplete block crossover design.

  7. Magnetic resonance imaging in deep pelvic endometriosis: iconographic essay

    Energy Technology Data Exchange (ETDEWEB)

    Coutinho Junior, Antonio Carlos; Coutinho, Elisa Pompeu Dias; Lima, Claudio Marcio Amaral de Oliveira; Ribeiro, Erica Barreiros; Aidar, Marisa Nassar [Clinica de Diagnostico por Imagem (CDPI), Rio de Janeiro, RJ (Brazil); Clinica Multi-Imagem, Rio de Janeiro, RJ (Brazil); E-mail: cmaol@br.inter.net; Gasparetto, Emerson Leandro [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Dept. de Radiologia

    2008-03-15

    Endometriosis is characterized by the presence of normal endometrial tissue outside the uterine cavity. In patients with deep pelvic endometriosis, uterosacral ligaments, rectum, rectovaginal septum, vagina or bladder may be involved. Clinical manifestations may be variable, including pelvic pain, dysmenorrhea, dyspareunia, urinary symptoms and infertility. Complete surgical excision is the gold standard for treating this disease, and hence the importance of the preoperative work-up that usually is limited to an evaluation of sonographic and clinical data. Magnetic resonance imaging is of paramount importance in the diagnosis of endometriosis, considering its high accuracy in the identification of lesions intermingled with adhesions, and in the determination of peritoneal lesions extent. The present pictorial review describes the main magnetic resonance imaging findings in deep pelvic endometriosis. (author)

  8. The unicornuate uterus with an occult adenomyotic rudimentary horn.

    Science.gov (United States)

    Frontino, Giada; Bianchi, Stefano; Ciappina, Nevio; Restelli, Elisa; Borruto, Franco; Fedele, Luigi

    2009-01-01

    We report 2 case of an atypical variant of unicornuate uterus in 2 adolescent patients with severe dysmenorrhea. Pelvic ultrasonography and magnetic resonance imaging identified a normal uterine contour. On the right side within the uterine fundus, a nodule was detected with a small hypoechogenic content. At laparoscopy the uterus and adnexae appeared to be normal. No endometriotic lesions were identified. Hysteroscopy identified a single regular cervical canal and a uterine cavity resembling that of a left unicornuate uterus, with a single regular left tubal ostium. Complete resection of the right uterine nodule along with an ipsilateral salpingectomy was performed. The nodule contained a small endometrial cavity and hematometra. Histologic study showed a cavitated adenomyotic uterine rudiment. The patients were discharged on the second postoperative day. No intraoperative or postoperative complications or recurrence of pelvic pain occurred.

  9. Isolation and anticomplement activity of compounds from Dendropanax morbifera.

    Science.gov (United States)

    Park, Bo-Young; Min, Byung-Sun; Oh, Sei-Ryang; Kim, Jung-Hee; Kim, Tae-Jin; Kim, Dong-Hee; Bae, Ki-Hwan; Lee, Hyeong-Kyu

    2004-02-01

    Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrhea. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. Of these, compound 1 showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98 microM, whereas compounds 2-7 were inactive.

  10. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC.

    Science.gov (United States)

    Bharati, Abinash C; Sahu, Alakh N

    2012-01-01

    Medicinal plants are widely being used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Biophytum sensitivum DC (Oxalidaceae) is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrhea. It is a small, flowering, annual herb with sensitive leaves. It grows throughout tropical Africa and Asia, especially in Philippines and the hotter parts of India and Nepal. Phytochemical studies have shown that the major pharmacologically active constituents are amentoflavone and a polysaccharide fraction, BP100 III. Recent pharmacological study shows that it has antioxidant, immunomodulatory, anticancer, anti-inflammatory, chemoprotective, antidiabetic and wound healing potential. This review attempts to describe the ethnobotany, pharmacognosy, traditional uses, chemical constituents, and various pharmacologic activities and other aspects of B. sensitivum.

  11. Testing equality and interval estimation in binary responses when high dose cannot be used first under a three-period crossover design.

    Science.gov (United States)

    Lui, Kung-Jong; Chang, Kuang-Chao

    2015-01-01

    When comparing two doses of a new drug with a placebo, we may consider using a crossover design subject to the condition that the high dose cannot be administered before the low dose. Under a random-effects logistic regression model, we focus our attention on dichotomous responses when the high dose cannot be used first under a three-period crossover trial. We derive asymptotic test procedures for testing equality between treatments. We further derive interval estimators to assess the magnitude of the relative treatment effects. We employ Monte Carlo simulation to evaluate the performance of these test procedures and interval estimators in a variety of situations. We use the data taken as a part of trial comparing two different doses of an analgesic with a placebo for the relief of primary dysmenorrhea to illustrate the use of the proposed test procedures and estimators.

  12. A case report on toxic epidermal necrolysis with etoricoxib

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    J S Kameshwari

    2015-01-01

    Full Text Available Etoricoxib is a selective cyclo-oxygenase 2 (COX-2 enzyme inhibitor and is exploited for its analgesic activity in various disease conditions like osteoarthritis, gouty arthritis, acute pain including postoperative dental pain and primary dysmenorrhea, etc. Although highly efficacious in pain management the safety profile of this COX-2 inhibitor is yet to be established in a broader sense. Short-term clinical trials and postmarketing surveillance have shown a very rare incidence of very serious skin reactions like Steven Johnson syndrome or toxic epidermal necrolysis (TEN. In this case report, we summarize regarding a patient who developed TEN after treatment with etoricoxib for osteoarthritis that later resolved in 15 days after withdrawal and symptomatic treatment.

  13. The pharmacological effects of Salvia species on the central nervous system.

    Science.gov (United States)

    Imanshahidi, Mohsen; Hosseinzadeh, Hossein

    2006-06-01

    Salvia is an important genus consisting of about 900 species in the family Lamiaceae. Some species of Salvia have been cultivated world wide for use in folk medicine and for culinary purposes. The dried root of Salvia miltiorrhiza, for example, has been used extensively for the treatment of coronary and cerebrovascular disease, sleep disorders, hepatitis, hepatocirrhosis, chronic renal failure, dysmenorrhea, amenorrhea, carbuncles and ulcers. S. officinalis, S. leriifolia, S. haematodes, S. triloba and S. divinorum are other species with important pharmacological effects. In this review, the pharmacological effects of Salvia species on the central nervous system will be reviewed. These include sedative and hypnotic, hallucinogenic, skeletal muscle relaxant, analgesic, memory enhancing, anticonvulsant, neuroprotective and antiparkinsonian activity, as well as the inhibition of ethanol and morphine withdrawal syndrome.

  14. Experimental treatments of endometriosis.

    Science.gov (United States)

    Attar, Rukset; Attar, Erkut

    2015-08-01

    Endometriosis is defined as the presence of endometrial gland and stroma outside the uterine cavity. It is an estrogen-dependent disease and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia and infertility. The treatment of endometriosis is conservative or radical surgery, medical therapies or their combination. All currently used hormonally active treatments are effective in the treatment of endometriosis; however, the adverse effects of these hormonal treatments limit their long-term use. Moreover, recurrence rates are high after cessation of therapy, and the treatments have no benefit in endometriosis-associated infertility. Therefore, researchers are working on new treatment modalities with improved side effects, mainly focusing on the molecular targets involved in etiopathogenesis of endometriosis. Here we summarized these novel treatments modalities.

  15. Asymptomatic presentation of silent uterine perforation by Cu-T 380A: a case report with review of literature

    Directory of Open Access Journals (Sweden)

    Sunder Pal Singh

    2014-08-01

    Full Text Available Copper containing intrauterine contraceptive device are used worldwide and considered to be safe, effective, reversible and long term method of birth control. While IUCDs are tolerated well by most of the women, they are also associated with adverse effects like bleeding and dysmenorrhea. Uterine perforation during Cu-T insertion is one of the rarest complications and 30% of which are asymptomatic and can be presented with serious complications if not diagnosed early. This complication can be avoided if proper techniques are used by gynaecologists and health professionals. Education and counseling of the women about feeling the IUCD string after every menstrual cycle and post insertion of IUCD is equally important to facilitate the early detection of misplaced IUCD to prevent serious complications like uterine perforation. [Int J Reprod Contracept Obstet Gynecol 2014; 3(4.000: 1157-1159

  16. Suprofen: the pharmacology and clinical efficacy of a new non-narcotic peripheral analgesic.

    Science.gov (United States)

    Tolman, E L; Rosenthale, M E; Capetola, R J; McGuire, J L

    1984-08-01

    Suprofen is a potent, peripherally-acting, non-narcotic analgesic agent. The mechanism of action of the compound involves inhibition of prostaglandin biosynthesis and, perhaps, direct antagonism of the peripheral, pain inducing actions of prostaglandins, bradykinin and other pain mediators. Suprofen at a dose of 200 mg appears to be equal or greater in efficacy as an analgesic modality than those of ibuprofen, propoxyphene, naproxen and diflunisal or a combination of 650 mg aspirin plus 60 mg codeine. Its clinical utility has been amply demonstrated in the treatment of a number of types of pain including general and orthopedic surgery, episiotomy, post-partum pain, dysmenorrhea, dental pain and musculoskeletal disorders. Suprofen represents a new class of orally effective nonnarcotic analgesics with potential for effective clinical use in the treatment of pain.

  17. Elastin distribution in the normal uterus, uterine leiomyomas, adenomyosis and adenomyomas: a comparison.

    Science.gov (United States)

    Zheng, Wei-Qiang; Ma, Rong; Zheng, Jian-Ming; Gong, Zhi-Jing

    2006-04-01

    To describe the histologic distribution of elastin in the nonpregnant human uterus, uterine leiomyomas, adenomyosis and adenomyomas. Uteri were obtained from women undergoing hysterectomy for benign conditions, including 26 cases of uterine leiomyomas, 24 cases of adenomyosis, 18 adenomyomas and 6 cases of autopsy specimens. Specific histochemical staining techniques were employed in order to demonstrate the distribution of elastin. The distribution of elastin components in the uterus was markedly uneven and showed a decreasing gradient from outer to inner myometrium. No elastin was present within leiomyomas, adenomyomas or adenomyosis. The distribution of elastin may help explain the normal function of the myometrium in labor. It implies that the uneven distribution of elastin components and absence of elastin within leiomyomas, adenomyomas and adenomyosis could be of some clinical significance. The altered elastin distribution in disease states may help explain such symptoms as dysmenorrhea in uterine endometriosis.

  18. 月经不调的中医护理

    Institute of Scientific and Technical Information of China (English)

    马庆彤; 李增云

    2015-01-01

    Menstrual disease syndrome refers to the menstrual period, quantity, color, quality is abnormal, and accompanied by menstrual cycle symptoms is a kind of disease characteristics. Clinical common disease and syndrome have menstruation irregular menstruation, dysmenorrhea, amenorrhea, uterine bleeding, by the line before and after the menstrual period syndromes, the syndrome etc..%月经病证是指月经的期、量、色、质发生异常,以及伴随月经周期出现明显症状为特点的一类疾病。临床常见的月经病证有月经不调、痛经、闭经、崩漏、经行前后诸证、经期前后诸证等。

  19. Promoting the menstrual health of adolescent girls in China.

    Science.gov (United States)

    Su, Jing Jing; Lindell, Deborah

    2016-12-01

    In China, nurses have limited presence in schools, thus, adolescent girls often lack accurate information about menstrual health, which may lead to incorrect and unhealthy menstrual-related behavior. This study investigated the effects of a culturally and developmentally tailored nursing intervention on the menstrual health of adolescent girls in China. Following institutional review board approval, adolescent girls aged 12-15 were recruited from two schools. A quasi-experimental, pretest-posttest design examined the effects of five interactive education sessions on menstrual health. The final sample included 116 adolescent girls. Significant improvement was observed in the intervention group regarding menstrual knowledge, confidence in performing menstrual healthcare behavior, and dysmenorrhea related self-care behavior. A nurse-managed education program improved adolescent girls' menstrual knowledge, promoted a more positive attitude, encouraged confidence, and improved pain relief practice. We recommend that professional nurses globally advocate for school nursing and routine menstrual health education for adolescent girls.

  20. Metabolic evaluation and measurement of ovarian volume in polycystic ovary sydrome: a cross-sectional observational study

    Directory of Open Access Journals (Sweden)

    Mehtap Evran

    2016-03-01

    Full Text Available Purpose: Polycystic ovary sydrome is a disease of women in reproductive period, with hirsutism or hyperandrogenic signs in laboratory evaluation, causing infertility due to dysmenorrhea and unovulation. Accompanying insulin resistance and adiposity may increase cardiometabolic risk. In our study, we planned to represent the physical examination and laboratory findings of the patients diagnosed as polycystic ovary sydrome, together with andominal ultrasonographic evaluation of the ovaries. Material-methods: Twenty-two patients who admitted the endocrinology department with the complaints of hirsutism and dysmenorrhea were included in the study. Purpose: Polycystic ovary sydrome is a disease of women in reproductive period, with hirsutism or hyperandrogenic signs in laboratory evaluation, causing infertility due to dysmenorrhea and unovulation. Accompanying insulin resistance and adiposity may increase cardiometabolic risk. In our study, we planned to represent the physical examination and laboratory findings of the patients diagnosed as polycystic ovary sydrome, together with andominal ultrasonographic evaluation of the ovaries. Material and Methods: Twenty-two patients who admitted the endocrinology department with the complaints of hirsutism and dysmenorrhea were included in the study. Their ages, family histories, polycystic ovary sydrome phenotypes, first menstrual age, length of cyclus and physical examination findings were recorded. Ferriman and Gallwey score was used for hirsutism. Insulin resistance was calculated via HOMA-IR method by making the biochemical and hormonal tests. Ovarian volumes were measured by abdominal ultrasonography. SPSS-16 was used for the statistical analysis of the findings. Results: Mean age was 21.41+/-0.88. Polycystic ovary sydrome phenotypes were B in 40.9%, C in 31.8% and A in 27.3%. Cyclus length was normal in 31.8% (27-34 days. Ferriman and Gallwey score was and #8805;7 in all of the patients. Although

  1. The Effect Observation of Levonorgestrel-releasing Intrauterine System in Adenomyosis%左炔诺孕酮宫内缓释系统治疗子宫腺肌症的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴小平; 林美丽

    2014-01-01

    Objective:To study clinical effect of Levonorgestrel-releasing Intrauterine System in adenomyosis.Method:40 cases of uterine adenomyosis patients in our hospital from January 2012 to March 2013 were admitted for the study,the Levonorgestrel-releasing Intrauterine System was placed into the patient utero,the menstrual flow,dysmenorrhea of the degree,uterine size change were observed and analysed before and after treatment.Result:Before treatment the dysmenorrhea score,menstrual flow,CA125,uterine size were (84.12±4.90)points,(212.01±53.01)ml,(70.38±68.50)U/ml,(190.16±90.04)cm3,placed 3 months in patients with dysmenorrhea score,menstrual flow,CA125,respectively (21.50±8.11)points,(48.21±14.88)ml,(26.01±25.42)U/ml,the difference were statistically significant(P0.05).In addition,patients had no significant adverse reactions.Conclusion:The effect of Levonorgestrel-releasing Intrauterine System in the treatment of adenomyosis is obvious,this method can effectively improve patient menstrual flow,dysmenorrhea and other symptoms,and safe,reliable,it is worthy of clinical application.%目的:观察左炔诺孕酮宫内缓释系统治疗子宫腺肌症的临床疗效。方法:选取2012年1月-2013年3月笔者所在医院收治的40例子宫腺肌症患者为研究对象,将左炔诺孕酮宫内缓释系统放置到患者宫内,对放置前后患者月经量、痛经程度、子宫大小变化等进行全面的观察和分析。结果:放置前患者痛经评分、月经量、CA125、子宫大小分别为(84.12±4.90)分、(212.01±53.01)ml、(70.38±68.50)U/ml、(190.16±90.04)cm3,放置后3个月患者痛经评分、月经量、CA125分别为(21.50±8.11)分、(48.21±14.88)ml、(26.01±25.42)U/ml,差异有统计学意义(P0.05)。此外,患者均无出现明显不良反应。结论:左炔诺孕酮宫内缓释系统治疗子宫腺肌症效果明显,能有效改善患者月经量、痛经等症状,且安全可靠,值得在临床上推广应用。

  2. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC

    Directory of Open Access Journals (Sweden)

    Abinash C Bharati

    2012-01-01

    Full Text Available Medicinal plants are widely being used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Biophytum sensitivum DC (Oxalidaceae is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrhea. It is a small, flowering, annual herb with sensitive leaves. It grows throughout tropical Africa and Asia, especially in Philippines and the hotter parts of India and Nepal. Phytochemical studies have shown that the major pharmacologically active constituents are amentoflavone and a polysaccharide fraction, BP100 III. Recent pharmacological study shows that it has antioxidant, immunomodulatory, anticancer, anti-inflammatory, chemoprotective, antidiabetic and wound healing potential. This review attempts to describe the ethnobotany, pharmacognosy, traditional uses, chemical constituents, and various pharmacologic activities and other aspects of B. sensitivum.

  3. Examining the efficacy, safety, and patient acceptability of the etonogestrel implantable contraceptive

    Directory of Open Access Journals (Sweden)

    Heather Hohmann

    2009-07-01

    Full Text Available Heather HohmannDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Contraceptive implants provide long-acting, highly effective reversible contraception. The etonogestrel implant (ENG implant is a single rod implant that offers three years of efficacy. The ENG implant was designed to provide contraceptive efficacy by inhibiting ovulation and Pearl Index scores reported for this method are similar to other long-acting reversible contraception as well as similar to sterilization. The implant has been shown to be safe during breast feeding and may improve symptoms of dysmenorrhea and endometriosis. Irregular bleeding patterns can be expected with the device’s use and should be addressed in order to decrease rates of discontinuation.Keywords: contraception, Implanon®, progestin-only, ENG-implant

  4. Beta-adrenoceptors in obstetrics and gynecology.

    Science.gov (United States)

    Modzelewska, Beata

    2016-01-01

    One hundred and twenty years after the description of extracts from the adrenal medulla, the use of beta-blockers and beta-agonists evolved from antianginal drugs and tocolytics to ligand-directed signaling. Beta-blockers in the fields of obstetrics and gynecology have so far been limited to the consideration of continuing treatment of disorders of the cardiovascular system and other dysfunctions that started before pregnancy. Studies in recent years have shown that beta-adrenoceptor signaling might be crucial in carcinogenesis and metastasis, apoptosis and anoikis. On the other hand, the use of beta-adrenoceptor agonists in tocolysis is, as yet, the primary method for inhibiting premature uterine contractions. Unfortunately, the efficacy of current pharmacological treatment for the management of preterm labor is regularly questioned. Moreover, studies related to non-pregnant myometrium performed to date indicate that the rhythmic contractions of the uterus are required for menstruation and have an important role in human reproduction. In turn, abnormal uterine contractility has been linked to dysmenorrhea, a condition associated with painful uterine cramping. The benefits of the use of beta2-adrenoceptor agonists in dysmenorrhea are still unclear and should be balanced against a wide range of adverse effects recognized with this class of medication. The ideal tocolytic agent is one which is effective for the pregnant or non-pregnant woman but has no side effects on either the woman or the baby. Looking to the future with both caution and hope, the potential metamorphosis of beta3-adrenoceptor agonists from experimental tools into therapeutic drugs for tocolysis warrants attention.

  5. Long-term results of symptomatic fibroids treated with uterine artery embolization: In conjunction with MR evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Man Deuk [Department of Diagnostic Radiology Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of)], E-mail: mdkim@cha.ac.kr; Lee, Hyun Seok [Department of Diagnostic Radiology Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of); Lee, Mee Hwa [Department of Obstetrics and Gynecology, Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of); Kim, Hee Jin [Department of Diagnostic Radiology Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of); Cho, Jin Ho; Cha, Sun Hee [Department of Obstetrics and Gynecology, Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of)

    2010-02-15

    Objective: The aim of the present study is to determine long-term clinical efficacy of uterine fibroid embolization (UFE) for symptomatic fibroids in conjunction with MR evaluation. Materials and methods: Sixteen patients with a follow-up period of 4 years or longer were analyzed retrospectively. Ages ranged from 27 to 45 (mean 39.5) years. Mean follow-up periods were 5.8 years (range: 4.1-6.9 years). The symptom changes, in terms of menorrhagia and dysmenorrhea and bulk-related symptoms, were assessed. The primary embolic agent was polyvinyl alcohol particle (250-710 {mu}m). All patients underwent preprocedural and long-term follow up MR imaging. Uterine volumes were calculated using MRI. Results: Symptom improvements were reported for menorrhagia (8/9, 88.9%), dysmenorrhea (5/5, 100%), and bulk-related symptoms (7/9, 77.8%) at long-term follow up. Two patients (12.5%) had symptom recurrences at long-term follow-up. Tumor regrowth from incomplete infarction was a cause of recurrence in one patient and newly developed leiomyomas in the other one. One patient underwent hysterectomy because endometriosis developed 4 years after UFE. Of the 14 necrotic myomas on short-term follow up MR after UFE, eight (57.1%) demonstrated maintaining necrosis with further shrinkage and six (42.9%) were no longer visualized on long-term follow up MR images. Overall, the mean volume reduction rates of the predominant fibroid and uterus were 80.5%, 36.7% at long-term follow up, respectively. Conclusion: UFE is an effective treatment for symptomatic fibroids with an acceptable long-term success rate. Long-term MR imaging after UFE revealed persistent necrotic fibroid, non-visualization of fibroids and tumor regrowth when incompletely infarcted.

  6. A twelve-month comparative clinical investigation of two low-dose oral contraceptives containing 20 micrograms ethinylestradiol/75 micrograms gestodene and 20 micrograms ethinylestradiol/150 micrograms desogestrel, with respect to efficacy, cycle control and tolerance.

    Science.gov (United States)

    Endrikat, J; Jaques, M A; Mayerhofer, M; Pelissier, C; Müller, U; Düsterberg, B

    1995-10-01

    The aim of this study was to compare contraceptive reliability, cycle control and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol and 75 micrograms gestodene, with a reference preparation containing the same dose of estrogen combined with 150 micrograms desogestrel. This article presents interim data from centers in France and Austria, involving a total of 479 women and 4,991 cycles. Contraceptive reliability was good with both preparations. Two pregnancies occurred in the gestodene group, but neither were due to method failure. In the desogestrel group there were also two pregnancies, of which one was due to method failure. With respect to cycle control, there is a trend towards a lower incidence of intermenstrual bleeding in the gestodene group. The incidence of spotting (scanty bleeding) during the important first three cycles was 3.5% lower in the gestodene group, and over the first six cycles, it was 7.6% lower. Amenorrhea was similar in both groups, but the incidence of dysmenorrhea was significantly lower in the gestodene group (p=0.001). Adverse events were similar in both groups, with headache, breast tension and nausea the most frequently reported symptoms. Body weight remained relatively constant during treatment in both groups, and no hypertension was reported for any woman during the course of the study. In each treatment group, 19 women discontinued because of adverse events. It is concluded that both preparation are reliable and well tolerated oral contraceptives are reliable and well tolerated oral contraceptives; however, there is a more favourable effect on dysmenorrhea by the gestodene formulation.

  7. Clinical and psychological repercussions of videolaparoscopic tubal ligation: observational, single cohort, retrospective study

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    Daniel Spadoto Dias

    Full Text Available CONTEXT AND OBJECTIVE: Tubal ligation is one of the most commonly used contraceptive methods worldwide. Since the controversy over the potential effects of tubal sterilization still continues, this study aimed to evaluate the clinical and psychological repercussions of videolaparoscopic tubal ligation.DESIGN AND SETTING: Observational, single cohort, retrospective study, conducted in a tertiary public hospital.METHODS: A questionnaire was applied to 130 women aged 21-46 years who underwent videolaparoscopic tubal ligation by means of tubal ring insertion or bipolar electrocoagulation and sectioning, between January 1999 and December 2007. Menstrual cycle interval, intensity and duration of bleeding, premenstrual symptoms, dysmenorrhea, dyspareunia, noncyclic pelvic pain and degree of sexual satisfaction were assessed in this questionnaire. Each woman served as her own control, and comparisons were made between before and after the surgical procedure and between the two techniques used.RESULTS: The clinical and psychological repercussions were significant, with increases in bleeding (P = 0.001, premenstrual symptoms (P < 0.001, dysmenorrhea (P = 0.019 and noncyclic pelvic pain (P = 0.001; and reductions in the number of sexual intercourse occurrences per week (P = 0.001 and in libido (P = 0.001. Women aged ≤ 35 years at the time of sterilization were more likely to develop menstrual abnormalities. The bipolar electrocoagulation method showed greater clinical and psychological repercussions.CONCLUSION: Regardless of the technique used, videolaparoscopic tubal ligation had repercussions consisting of increased menstrual flow and premenstrual symptoms, especially in women aged ≤ 35 years, and also had a negative influence on sexual activity.

  8. Obstetrics and gynecology outpatient scenario of an Indian homeopathic hospital: A prospective, research-targeted study.

    Science.gov (United States)

    Saha, Subhranil; Koley, Munmun; Saha, Sangita; Singh, Rakesh; Hossain, Md Monowar; Pramanik, Indrani

    2016-04-01

    The authors aimed to document prescriptions and clinical outcomes in routine homeopathic practice to short list promising areas of targeted research and efficacy trials of homeopathy in obstetrics and gynecology (O&G). Three homeopathic physicians participated in methodical data collection over a 3-month period in the O&G outpatient setting of The Calcutta Homeopathic Medical College and Hospital, West Bengal, India. A specifically designed Excel spreadsheet was used to record data on consecutive appointments, including date, patient identity, socioeconomic status, place of abode, religion, medical condition/complaint, whether chronic/acute, new/follow-up case, patient-assessed outcome (7-point Likert scale: -3 to +3), prescribed homeopathic medication, and whether other medication/s was being taken for the condition. These spreadsheets were submitted monthly for data synthesis and analysis. Data on 878 appointments (429 patients) were collected, of which 61% were positive, 20.8% negative, and 18.2% showed no change. Chronic conditions (93.2%) were chiefly encountered. A total of 434 medical conditions and 52 varieties were reported overall. The most frequently treated conditions were leucorrhea (20.5%), irregular menses (13.3%), dysmenorrhea (10%), menorrhagia (7.5%), and hypomenorrhea (6.3%). Strongly positive outcomes (+3/+2) were mostly recorded in oligomenorrhea (41.7%), leucorrhea (34.1%), polycystic ovary (33.3%), dysmenorrhea (28%), and irregular menses (22.2%). Individualized prescriptions predominated (95.6%). A total of 122 different medicines were prescribed in decimal (2.9%), centesimal (87.9%), and 50 millesimal potencies (4.9%). Mother tinctures and placebo were prescribed in 3.4% and 30.4% instances, respectively. Several instances of medicine-condition pairings were detected. This systematic recording cataloged the frequency and success rate of treating O&G conditions using homeopathy.

  9. Effect of Guizhifuling capsule combined with levonorgestrel releasing intrauterine system on adenomyosis

    Institute of Scientific and Technical Information of China (English)

    Dong-Tao Shi; Rui Bai

    2016-01-01

    Objective:To explore the clinical efficacy of Guizhifuling capsule combined with levonorgestrel releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis (AM). Methods: A total of 80 patients with AM who were admitted in our hospital from February, 2015 to February, 2016 were included in the study and randomized into the study group and the control group. LNG-IUS was placed in patients in the two groups 7 d after menstruation. The patients in the study group were given additional Guizhifuling capsule, 3 capsules/time, 3 times/d, and the drug was withdrawn in the menstrual period. Six-month treatment was regarded as one course. PBAC was used to evaluate the menstrual blood volume before and after treatment. The chronic pain grading questionnaire method was used for dysmenorrhea degree rating. The vaginal B ultrasound 3 d after menstruation was performed to detect the uterine volume. E2, FSH, LH, and serum CA125 level before and after treatment were detected.Results: The menstrual blood volume, dysmenorrhea degree, and uterine volume after treatment in the two groups were significantly reduced when compared with before treatment (P0.05). After treatment, CA125 level in the two groups was significantly reduced when compared with before treatment (P<0.05), and the reduced degree in the study group was significantly superior to that in the control group (P<0.05).Conclusions:Guizhifuling capsule combined with LNG-IUS in the treatment of AM can significantly improve the clinical symptoms, effectively reduce CA125 level, and has no significant effect on the sex hormone levels with a satisfactory clinical efficacy; therefore, it deserves to be widely recommended in the clinic.

  10. Analysis on Clinical Effect of Mirena in Treatment of Adenomyosis%曼月乐节育环治疗子宫腺肌症临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    刘桃

    2014-01-01

    Objective To explore intrauterine device on Mirena in the treatment of adenomyosis clinical efficacy and side effects .Methods 38 cases of adenomyosis treated with levonorgestrel-releasing intrauterine device were analyzed for menstrual blood volume ,degree of dysmenorrhea,and volume of uterus before and after the im-plantation of intrauterine device.Results The grades of both postoperative dysmenorrhea and menstrual volume markedly decreased,with statistical significance(P<0. 01).The uterus presented a corresponding shrinkage in volume,while there was no statistical differences.Conclusion Levonorgestrel intrauterine device has preferably curative effect and fewer side effect in the treatment of adenomyosis .%目的:探讨宫内节育器曼月乐环在治疗子宫腺肌病中的临床疗效及副反应。方法观察38例子宫腺肌症患者在放置曼月乐环前后月经量、痛经程度以及子宫体积的变化。结果子宫腺肌病患者在放置曼月乐环后痛经程度显著减轻(P<0.01),月经量显著减少(P<0.01),子宫体积相应减小(但差异无显著性)。结论曼月乐环对于治疗子宫腺肌病有较好疗效及较小的副作用。

  11. Menstrual Abnormalities in School Going Girls – Are They Related to Dietary and Exercise Pattern?

    Science.gov (United States)

    Vani K., Rupa; K.S., Veena; L., Subitha; Kumar V.R., Hemanth; A., Bupathy

    2013-01-01

    Context: Adolescence is the transitional phase of physical and mental development between childhood and adulthood and is characterized by immense hormonal changes.75% of girls experience some problems associated with menstruation. Aim: We tried to find out the prevalence of menstrual abnormalities in school going girls in Pondicherry and their association with dietary and exercise habits. Setting and Design: A cross-sectional questionnaire based study was conducted in adolescent girls who attained menarche in four secondary schools of Pondicherry, India. Material and Methods: All students who attained menarche and willing to participate in the study were invited to answer the questionnaire, which dealt with anthropometric data, socioeconomic data, menstrual history, and diet and exercise pattern. Statistical Analysis: Chi-square test and Fisher’s exact test was used to compare the dietary and exercise patterns among students having menstrual abnormalities and those who do not have menstrual abnormalities. Results: A total of 853 students participated in the study. Dysmenorrhea and premenstrual symptoms were the most frequent problems encountered. Premenstrual symptoms were significantly more common among girls who were overweight, in girls who were eating junk food regularly, in girls who were eating less food (dieting) in order to lose weight and in those who were not doing regular physical activity. Dysmenorrhea was significantly more common in the girls who were dieting to lose weight. Passage of clots was also significantly high in the girls who were dieting. Conclusion: Lifestyle modifications like regular physical activity, decreasing the intake of junk food and promoting healthy eating habits should be emphasised in school health education programs to improve their menstrual health. PMID:24392394

  12. Evaluation of Risk Factors Associated with Endometriosis in Infertile Women

    Science.gov (United States)

    Ashrafi, Mahnaz; Sadatmahalleh, Shahideh Jahanian; Akhoond, Mohammad Reza; Talebi, Mehrak

    2016-01-01

    Background Endometriosis affects women’s physical and mental wellbeing. Symptoms include dyspareunia, dysmenorrhea, pelvic pain, and infertility. The purpose of this study is to assess the correlation between some relevant factors and symptoms and risk of an endometriosis diagnosis in infertile women. Materials and Methods A retrospective study of 1282 surgical patients in an infertility Institute, Iran between 2011 and 2013 were evaluated by laparoscopy. Of these, there were 341 infertile women with endometriosis (cases) and 332 infertile women with a normal pelvis (comparison group). Chi-square and t tests were used to compare these two groups. Logistic regression was done to build a prediction model for an endometriosis diagnosis. Results Gravidity [odds ratio (OR): 0.8, confidence interval (CI): 0.6-0.9, P=0.01], parity (OR: 0.7, CI: 0.6-0.9, P=0.01), family history of endometriosis (OR: 4.9, CI: 2.1-11.3, Pgalactorrhea (OR: 2.3, CI: 1.5-3.5, P=0.01), history of pelvic surgery (OR: 1.9, CI: 1.3-2.7, P0.05). Fatigue, diarrhea, constipation, dysmenorrhea, dyspareunia, pelvic pain and premenstrual spotting were more significant among late-stage endometriosis patients than in those with early-stage endometriosis and more prevalent among patients with endometriosis than that of the comparison group. In the logistic regression model, gravidity, family history of endometriosis, history of galactorrhea, history of pelvic surgery, dysmenorrhoea, pelvic pain, dysparaunia, premenstrual spotting, fatigue, and diarrhea were significantly associated with endometriosis. However, the number of pregnancies was negatively related to endometriosis. Conclusion Endometriosis is a considerable public health issue because it affects many women and is associated with the significant morbidity. In this study, we built a prediction model which can be used to predict the risk of endometriosis in infertile women. PMID:27123195

  13. Evaluation of Risk Factors Associated with Endometriosis in Infertile Women

    Directory of Open Access Journals (Sweden)

    Mahnaz Ashrafi

    2016-05-01

    Full Text Available Background: Endometriosis affects women’s physical and mental wellbeing. Symptoms include dyspareunia, dysmenorrhea, pelvic pain, and infertility. The purpose of this study is to assess the correlation between some relevant factors and symptoms and risk of an endometriosis diagnosis in infertile women. Materials and Methods: A retrospective study of 1282 surgical patients in an infertility Institute, Iran between 2011 and 2013 were evaluated by laparoscopy. Of these, there were 341 infertile women with endometriosis (cases and 332 infertile women with a normal pelvis (comparison group. Chi-square and t tests were used to compare these two groups. Logistic regression was done to build a prediction model for an endometriosis diagnosis. Results: Gravidity [odds ratio (OR: 0.8, confidence interval (CI: 0.6-0.9, P=0.01], parity (OR: 0.7, CI: 0.6-0.9, P=0.01, family history of endometriosis (OR: 4.9, CI: 2.1-11.3, P0.05. Fatigue, diarrhea, constipation, dysmenorrhea, dyspareunia, pelvic pain and premenstrual spotting were more significant among late-stage endometriosis patients than in those with early-stage endometriosis and more prevalent among patients with endometriosis than that of the comparison group. In the logistic regression model, gravidity, family history of endometriosis, history of galactorrhea, history of pelvic surgery, dysmenorrhoea, pelvic pain, dysparaunia, premenstrual spotting, fatigue, and diarrhea were significantly associated with endometriosis. However, the number of pregnancies was negatively related to endometriosis. Conclusion: Endometriosis is a considerable public health issue because it affects many women and is associated with the significant morbidity. In this study, we built a prediction model which can be used to predict the risk of endometriosis in infertile women.

  14. Visceral pain as a triggering factor for fibromyalgia symptoms in comorbid patients.

    Science.gov (United States)

    Costantini, Raffaele; Affaitati, Giannapia; Wesselmann, Ursula; Czakanski, Peter; Giamberardino, Maria Adele

    2017-10-01

    Fibromyalgia syndrome (FMS) is a central sensitization syndrome; however, peripheral pain sources potentially exacerbate its symptoms of chronic diffuse musculoskeletal pain and hyperalgesia. This prospective study evaluated visceral pain as a possible triggering factor for FMS pain and hyperalgesia in comorbid patients. Women with (1) FMS + irritable bowel syndrome (IBS); (2) FMS + primary dysmenorrhea (Dys); (3) FMS + Dys secondary to endometriosis (Endo); (4) FMS + colon diverticulosis (Div) were compared with FMS-only women, for fibromyalgia pain (number and intensity of episodes and analgesic consumption) over comparable periods and for somatic hyperalgesia (electrical and pressure pain thresholds) in painful (tender points) and control areas (trapezius, deltoid, quadriceps muscles, and overlying subcutis and skin). In comorbid subgroups, FMS symptoms were also reassessed after treatment of the visceral condition or no treatment. All comorbid groups vs FMS-only had significantly higher FMS pain (number/intensity of episodes and analgesic consumption) and hyperalgesia in deep somatic tissues (subcutis and muscle) at all sites (0.05 Visceral pain (number of IBS days, painful menstrual cycles, and abdominal pain episodes from diverticulitis) correlated directly with all parameters of FMS pain and inversely with muscle pain thresholds at all sites (0.03 pain and hyperalgesia in all tissues and all sites significantly decreased in patients after visceral comorbidity treatment (dietary for 6 months [IBS], hormonal for 6 months [dysmenorrhea], laser [endometriosis], and surgery [diverticulosis]) (0.05 Visceral pain enhances FMS symptoms, probably augmenting the level of central sensitization typical of the syndrome. Systematic assessment and treatment of visceral pain comorbidities should be a part of FMS management strategy.

  15. Predicted Value of Serum Prostaglandin E2 on the Dysmenorrheal Treatment Effect in Adenomyosis Patients with Levonorgestrel-releasing Intrauterine System%血清前列腺素E2预测左炔诺孕酮缓释系统治疗子宫腺肌病痛经效果的价值探讨

    Institute of Scientific and Technical Information of China (English)

    杨丽华; 徐勤; 胡万芹

    2013-01-01

    Objective: To explore the possibility of the serum prostaglandin E2(PGE2) level predictive value on the dysmenorrheal treatment effect in the adenomyosis (ADS) patients with levonorgestrel-releas-ing intrauterine system (LNG-IUS). Methods: Forty-one ADS patients treated with LNG-IUS because of dysmenorrhea were collected. These patients were divided into effective group (n=32) and noneffective group (n=9) according to the effect of relieving dysmenorrhea. The serum PGE2 level before and after 6 months of the LNG-IUS treatment were compared by ELISA, and the influence of serum PGE2 level caused by LNG-IUS and the correlation between the serum PGE2 level and the dysmenorrheal treatment effect with LNG-IUS were analyzed. Results: The serum PGE2 concentrations were 20.95 ± 3.07 pg/ml and 5.56 ± 1.72 pg/ml in the effective group before and after 6 months with LNG-IUS treatment, there was a significant difference between them (P<0.05). The serum PGE2 concentrations were 5.74 ±1.12 pg/ml and 4.95±1.39 pg/ml in the noneffective group before and after 6 months with LNG-IUS treatment, there was no significant difference between them. The serum PGE2 concentration in the effective group was significantly higher than that in the noneffective group (P<0.05). The change of visual analogue scale (VAS) score after 6 months of LNG-IUS treatment had a positive correlation with the serum PGE2 level before LNG-IUS treatment, the higher serum PGE2 concentration was, the more obviously the VAS score decreased (r=0.845, P<0.05). Conclusion: PGE2 might be involved in the occurrence of ADS dysmenorrhea and LNG-IUS relieved dysmenorrhea through decreasing the PGE2 level. It is suggested that the patients with high PGE2 level choose LNG-IUS to treat their dysmenorrhea and the patients with low PGE2 level use other ways to treat dysmenorrhea.%目的:探讨子宫腺肌病(adenomyosis,ADS)患者血清前列腺素E2(prostaglandin E2,PGE2)水平预测左

  16. The Effects of Deqi and Manual Acupuncture Needle Manipulation on the Clinical Outcomes of Acupuncture Analgesia%得气、针刺手法与针刺治疗原发性痛经疗效的关系

    Institute of Scientific and Technical Information of China (English)

    熊瑾; 刘芳; 王伟; 黄光英

    2011-01-01

    Objective: To observe the effects of deqi and manual acupuncture needle manipulation on the acupuncture treatment for primary dysmenorrhea, and to explore the relationship between them. Methods :90 patients with primary dysmenorrhea were randomly divided into manual acupuncture needle manipulation and needle non - manipulation group. The deqi sensations listed in the questionnaire or any other sensations occurred during the treatment were quantified on a numerical scale of 0 - 4 by the volunteers. The pain intensity,pain duration and related symptoms were used to evaluate the clinical success of acupuncture. Results;Two groups showed significant differences in effective percentage (P <0. 001). The manual needle manipulation group showed a significant greater improvement in pain intensity and pain duration compared with the control group ( P < 0. 001). Statistical analysis of the data revealed an obvious correlation between deqi and clinical outcomes of acupuncture analgesia, and the related coefficient was 0. 647 (P <0. 001) . Conclusion;It was suggested that deqi may be the predictor of the treatment outcomes which determine the clinical success of acupuncture treatment for primary dysmenorrhea. Furthermore, it will elicit and enhance the deqi response and achieve the therapeutic benefits in the treatment of acupuncture taking the manual needle manipulation.%目的:观察得气、针刺手法对针刺治疗原发性痛经疗效的影响,探讨手法、得气与针刺镇痛疗效三者之间关系.方法:对90例原发性痛经患者按照完全随机的方法分成针刺手法组和针刺非手法组.对患者得气感觉的程度按照0~4分的量度进行评估.记录针刺治疗前后患者的疼痛程度(VAS)、疼痛持续时间及伴随症状来评估疗效.结果:手法组的有效率显著高于非手法组(P<0.001).两组在疼痛程度、疼痛持续时间上差异均有统计学意义(P<0.001).得气指标与痛经疗效指标之间呈正相关(R=0

  17. Anatomical distribution of pelvic deep infiltrating endometriosis and its relationship with pain symptoms

    Institute of Scientific and Technical Information of China (English)

    DAI Yi; LENG Jin-hua; LANG Jing-he; LI Xiao-yan; ZHANG Jun-ji

    2012-01-01

    Background Endometriosis is a controversial and enigmatic disease.Deep infiltrating endometriosis (DIE) is responsible for painful symptoms and is the least understood type of endometriosis.Little work has been devoted to define the location of DIE lesions and its relationships with pain.The aim of the study was to investigate the relationship between the anatomical distribution of DIE lesions and pain symptoms.Methods Clinical data from 354 patients between May 2003 and December 2007 with laparoscopically diagnosed endometriosis were collected including 177 DIE patients and 177 non-DIE patients.The pain symptoms,including dysmenorrhea (DM),chronic pelvic pain (CPP,defined as intermittent or permanent pelvic pain,not related to the menstruation and longer than 6 months),deep dyspareunia (pelvic pain at intercourse) and dyschezia (pelvic pain with defecation),were recorded for every patient before operation.Endometriotic lesions were recorded by their anatomical distributions,the depth of infiltration and lesion colors.And the relationship between the anatomical distribution of DIE lesions and pain symptoms was analyzed.Pearson's chi-square test or Fisher's exact test,one-way analysis of variance (ANOVA) and linear regression and binary Logistic regression were used for statistical analysis.Results The duration ((13.79±3.94) years) of pain suffering in DIE patients was much longer than that of non-DIE patients (P <0.01).In DIE patients,60.7% of the uterosacral ligament (USL) nodules were bilateral (P <0.01); 44.6% of the cul-de-sacs were completely blocked.Rectum invasion was observed in 19.9% of DIE patients (P=0.03); pelvic adhesion was also more common.Up to 98.41% of the deep infiltrative lesions were located in the posterior pelvic compartment.DIE lesions were also found in bladder (1.58%),USL (67.08%),cul-de-sac (12.02%),recto-vaginal septum (12.66%),rectum and rectosigmoid junction (2.85%) and ureter (3.80%).The odds ratio of USL

  18. Hubungan Aktivitas Fisik Harian dengan Gangguan Menstruasi pada Mahasiswa Fakultas Kedokteran Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Putri Anindita

    2016-09-01

    Full Text Available  AbstrakGangguan menstruasi dapat menimbulkan stres dan menurunkan kualitas hidup wanita. Gambaran menstruasi seseorang dapat memperlihatkan keadaan fungsi reproduksi seseorang dan risiko mengalami berbagai penyakit. Aktivitas fisik diperkirakan sebagai salah satu cara untuk mengurangi terjadinya gangguan menstruasi tersebut. Tujuan penelitian ini adalah menentukan hubungan antara aktivitas fisik harian dan gangguan menstruasi. Desain penelitian  menggunakan cross sectional study dengan jumlah subjek 90 mahasiswi Fakultas Kedokteran Universitas Andalas Angkatan 2011-2013. Data didapatkan dari kuisioner yang diisi langsung oleh masing-masing responden yang kemudian dianalisis denga uji chi-square. Hasil penelitian mendapatkan gangguan menstruasi terjadi pada 73,3% mahasiswi dengan gangguan yang paling sering terjadi yaitu dysmenorrhea sebanyak 63,3%. Sebagian besar mahasiswi tersebut memiliki aktivitas fisik harian yang cukup menurut rekomendasi WHO yaitu sebanyak 60%. Berdasarkan uji chi-square, tidak ditemukan adanya hubungan antara aktivitas fisik harian dan gangguan menstruasi (p= 0,846. Kesimpulan ialah tidak terdapat hubungan yang bermakna antara aktivitas fisik harian dan gangguan menstruasi pada mahasiswi Fakultas Kedokteran Universitas Andalas.Kata kunci: aktivitas fisik, gangguan menstruasi, mahasiswi FK AbstractMenstrual disorder is often cause stress and decrease the life quality of a woman. Menstrual pattern can describe the condition of reproduction function and risk of having several disease. Physical Activity is considered as one of the way to reduce menstrual disorder. The objective of this study was to determine the association between daily physical activity and menstrual disorder.This  study  used cross sectional design on 90 female medical student of Andalas University Class of 2011-2013 as the sample. The data from self reported questionnaire that was given to the students is analyzed using chi-square.The results show

  19. Anxiety and depression in patients with endometriosis: impact and management challenges

    Directory of Open Access Journals (Sweden)

    Laganà AS

    2017-05-01

    Full Text Available Antonio Simone Laganà,1 Valentina Lucia La Rosa,2 Agnese Maria Chiara Rapisarda,3 Gaetano Valenti,3 Fabrizio Sapia,3 Benito Chiofalo,1 Diego Rossetti,4 Helena Ban Frangež,5 Eda Vrtačnik Bokal,5 Salvatore Giovanni Vitale1 1Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G Barresi”, University of Messina, Messina, 2Unit of Psychodiagnostics and Clinical Psychology, 3Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, 4Department of Maternal and Child Health, Gavardo Hospital, Brescia, Italy; 5Department of Reproduction, University Medical Center Ljubljana, Ljubljana, Slovenia Abstract: Endometriosis is one of the most common gynecological diseases and affects ~10% of women in reproductive age. The most common clinical signs of endometriosis are menstrual irregularities, chronic pelvic pain (CPP, dysmenorrhea, dyspareunia and infertility. Symptoms of endometriosis often affect psychological and social functioning of patients. For this reason, endometriosis is considered as a disabling condition that may significantly compromise social relationships, sexuality and mental health. Considering this point, the aim of this narrative review is to elucidate the impact of anxiety and depression in the management of women with endometriosis. Psychological factors have an important role in determining the severity of symptoms, and women who suffer from endometriosis report high levels of anxiety, depression and other psychiatric disorders. In addition, endometriosis is one of the most important causes of CPP; women with endometriosis suffer from a wide range of pelvic pain such as dysmenorrhea, dyspareunia, nonmenstrual (chronic pelvic pain, pain at ovulation, dyschezia and dysuria. Several studies have underlined the influence of CPP on quality of life and psychological well-being of women with endometriosis. Data suggest that the experience of pelvic pain is an

  20. Clinical observation of Mirena intrauterine device in the treatment of adenomyosis%曼月乐宫内节育器治疗子宫腺肌病的疗效观察

    Institute of Scientific and Technical Information of China (English)

    邓淑珍

    2014-01-01

    目的:探讨曼月乐宫内节育器( intrauterine device, IUD)治疗子宫腺肌病的临床疗效。方法选取郴州市第一人民医院中心医院2012年4月至2013年4月期间收治的子宫腺肌病患者共80例,随机分为观察组和对照组各40例。对照组给予药物治疗,观察组给予曼月乐IUD治疗,通过比较两组患者治疗前后的痛经情况、月经状况、子宫体积进行效果评价。结果治疗后两组患者临床症状均得到明显改善(P<0.05);观察组痛经程度,月经状况、子宫体积缩小程度,均明显优于对照组,差异有统计学意义(P<0.05)。结论曼月乐IUD对于治疗子宫腺肌病有一定的临床价值。%Objective To explore the clinical effect of Mirena intrauterine device on adenomyosis. Methods 80 patients with adenomyosis from April 2012 to April 2013 in The Central Hospital of Chenzhou No. 1 People 's Hospital were chosen. All cases were randomized into observation group and control group with 40 cases in each group. Patients in control group were treated with medicine while patients in observation group were treated with Mirena intrauterine device. Dysmenorrhea, menses situation, uterine volume were compared between two groups to evaluate the effect. Results Clinical symptoms of patients in both groups were improved after treatment(P<0. 05). Improvement of dysmenorrhea, menses situation and uterine volume of patients in observation group were superior to that in control group(P<0. 05). Conclusion Mirena intrauterine device is effective in treatment of adenomyosis.

  1. At 10 years of chlormadinone use in Latin America: a review.

    Science.gov (United States)

    Barriga P, Patricio; Ambrosi Penazzo, Nicola; Franco Finotti, Marta; Celis, Alfredo A; Cerdas, Oscar; Chávez, Jorge Armando; Cuitiño, Luis Alfredo; Fernandes, César Eduardo; Plata, Manuel Antonio; Tirán-Saucedo, José; Vanhauwaert, Paula Sofía

    2016-07-01

    Chlormadinone acetate (CMA) is a progesterone derivative (17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961. It was used as progestin-based hormone replacement therapy; since 1999 it was first used for oral contraception combined with ethinyl estradiol (EE). CMA exerts a potent progestagenic effect, about one third higher than that observed with endogenous progesterone. CMA is also an anti-estrogen, showing no androgenic effects (at birth control dose). Unlike progesterone, it has a mild glucosteroidal effect with no anti-mineralocorticoid effect at all. These biological actions have allowed CMA to have a role for therapeutic use in dysmenorrhea, hyperandrogenism, and as a contraceptive agent. In addition, CMA has exhibited beneficial neuroendocrine effects on women's mood. CMA-EE combination has shown excellent contraceptive efficacy, high tolerability, and compliance due to its risk-benefit profile, having additional benefits on skin and hair, such as reduction of seborrhea and acne. Metabolic tolerance of CMA has been demonstrated in several clinical studies. Currently, CMA is formulated to be taken as oral caplets in a 21 caplets package containing 0.03 mg/EE and 2 mg CMA per pill with/without seven placebo additional pills. Another presentation has 24 caplets containing 0.02 mg/EE and 2 mg CMA plus four placebo pills.

  2. Research Progress of Prostaglandin in Endometriosis%前列腺素在子宫内膜异位症中的研究进展

    Institute of Scientific and Technical Information of China (English)

    徐燕颖

    2013-01-01

    子宫内膜异位症(EMs)是育龄期妇女的常见疾病,发病率为5% ~10%,是引起女性不孕的主要原因.患者多出现慢性盆腔痛、痛经、性交困难等症状,严重影响生活质量.EMs的病因复杂,其确切发病机制目前仍不明确.前列腺素E2(PGE2)是一种不稳定型的类花生四烯酸化合物,越来越多的证据表明,PGE2在EMs的病理生理过程中发挥关键作用,如细胞增殖、抗凋亡、免疫抑制和血管生成等.%Endometriosis is the primary cause of infertility in women,with a prevalence ranging from 5% to 10% .Women with endometriosis suffer from symptoms such as chronic pelvic pain,dysmenorrhea and dys-pareunia, which significantly reduce the quality of life.The etiology of Ems is complex,and the exact patho-genesis is still unclear.Prostaglandin E2( PGE2 )is an unstahle eicosanoid.A growing body of evidence demonstrates that PGE2 regulates many pathophysiological processes including cell proliferation, antiapoptosis, immune suppression and angiogenesis.

  3. Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra.

    Science.gov (United States)

    Shi, Yulu; Wu, Debin; Sun, Zhen; Yang, Jing; Chai, Hongyan; Tang, Li; Guo, Yue

    2012-09-01

    Shaoyao-gancao-tang, a Chinese medicinal formula consisting of peony and licorice has been used for the treatment of dysmenorrhea for thousands of years. The purpose of the present study was to demonstrate the analgesic and uterine relaxant effects of isoliquiritigenin (ISL), a flavonoid isolated from the roots of Glycyrrhiza glabra (a type of licorice). In vitro, isoliquiritigenin caused concentration-dependent inhibition of spontaneous contraction of isolated rat uterus and the contraction induced by various types of stimulants, such as acetylcholine (Ach, 10 mM), KCl (40 mM) and oxytocin (1 mU/mL). The uterine contractile response to cumulative concentrations of CaCl₂ was blocked by 0.1 and 1 mM of isoliquiritigenin. The isoliquiritigenin-induced relaxation was partly inhibited by the nitric oxide synthase (NOS) inhibitor Nv-nitro-L-arginine methylester (L-NAME, 100 mM) and the COX-1/COX-2 inhibitor indomethacin (10mM). In vivo, isoliquiritigenin could cause a significant reduction in the acetic acid-induced writhing response and hot-plate test at the high dose. These results indicate that isoliquiritigenin, a flavonoid isolated from the roots of Glycyrrhiza glabra, not only has a spasmolytic effect on uterine contraction, which is in relation to Ca²⁺ channels, NOS and COX, but also an effective activity in reducing pain.

  4. Consider prescribing OCs for perimenopause use.

    Science.gov (United States)

    2000-03-01

    Contraceptive experts advise the use of low-dose (20-35 mcg estrogen) oral contraceptives (OCs) for perimenopausal patients because of their numerous advantages over hormone replacement therapy. Benefits include effective contraception, regular menses, treatment of menorrhagia and dysmenorrhea, reduction of vasomotor symptoms, higher bone density and fewer fractures, and prevention of ovarian and endometrial cancers. Although age limits for OC use for healthy nonsmoking women have been lifted for some time, certain providers still hesitate to prescribe OCs. Moreover, epidemiological studies confirm that low-dose pills are safe for healthy, nonsmoking women with normal blood pressure. More definitive research also found that the increased risk was mainly related to smoking rather than age. Since smoking is an important risk factor in OC use, pill use by smokers over 35 years old is contraindicated. Instead, it is suggested that they use progestin-only pills, IUDs, or barrier contraceptives for birth control. Another research indicates that women who use the pill can decrease their risk of postmenopausal fractures.

  5. MISPLACED AND MIGRATED IUCD: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sankareswari

    2015-12-01

    Full Text Available Misplaced IUCD is the condition when the tail of IUCD is not seen through the cervical os. IUCD migration subsequent to uterine perforation is an uncommon but serious complication. Incidence of perforation varies from 1-3 per 1000 insertions. 4 24 years old female, P3L2A0 with the complaints of severe dysmenorrhea for 4years and abdominal pain with low back pain for 2years. She had 2FTND and IUCD inserted 6months after last delivery in April 2007. 5months later, with 2months amenorrhea, diagnosed as pregnancy with expulsion of IUCD, as there was no thread seen through external cervical os. USG was not done. This pregnancy was terminated at 7th month due to Anencephaly in February 2008. Interval laparoscopic sterilisation done in July 2010. USG on 28/09/2013 revealed IUCD in right ovary when she went for ovum donation and advised removal. After 7.5 years, on 11/10/2013 laparoscopic removal of IUCD done from right ovary which was surrounded by adhesions and pus. Perforated site seen in the fundus of uterus as depression. Appropriate antibiotics given. Post-operative period was uneventful. On follow up, the patient is free of abdominal pain and back pain. This case report highlights the need for vigilance in misplaced IUCD. Plain X ray abdomen and pelvis can pick up the diagnosis and exclude the perforation and migration. So that further complications and morbidity are prevented

  6. Cornual pregnancy as a complicaton of the use of a levonorgestrel intrauterine device: a case report

    Science.gov (United States)

    2009-01-01

    Introduction Complications of copper load intrauterine devices, including ectopic pregnancies are well reported. Rates of ectopic pregnancy are 0.6 to 1.1% per year. However, the levonorgestrel intrauterine device has been described as more protective against ectopic pregnancies due to the addition of the hormone levonorgestrel. The hormone released from the intrauterine device causes some systemic effects, but local effects such as glandular atrophy and stromal decidualization, in addition to foreign body reaction, are dominant. Few case reports have described ampullary ectopic pregnancies. However, we report, for the first time, a major complication of levonorgestrel intrauterine device: a cornual pregnancy. Case presentation A 36-year-old Caucasian nulliparous woman presented with complaints of progressive nausea, abdominal pain and irregular vaginal bleeding for 2 months. For 3 years, she had been using a levonorgestrel intrauterine device. A two-dimensional transvaginal sonogram noted a sac situated external to the endometrial cavity in the right cornua of the uterus with an empty uterus. She was successfully treated with chemotherapy. Conclusion Many complications have been described, including ectopic pregnancies, using copper intrauterine devices. The levonorgestrel-releasing intrauterine system is a particularly good choice for adolescents because of associated non-contraceptive benefits such as decreased menstrual bleeding, dysmenorrhea and pain associated with endometriosis [1]. Yet a cornual pregnancy following the use of a levonorgestrel intrauterine device is a complication which, to our knowledge, has not been described before. Physicians prescribing this type of intrauterine device should be aware of this rare event. PMID:19830226

  7. Effects of acupressure on menstrual distress and low back pain in dysmenorrheic young adult women: an experimental study.

    Science.gov (United States)

    Chen, Huei-Mein; Wang, Hsiu-Hung; Chiu, Min-Huei; Hu, Hsou-Mei

    2015-06-01

    The purpose of this study was to examine the effects of acupressure on menstrual distress and low back pain (LBP) in dysmenorrheic young adult women. In all, 129 female students, who had been experiencing dysmenorrhea with LBP during menstruation and who scored more than 4 points on the visual analog scale for pain, were randomly assigned to an experimental group and a control group. The experimental group (n = 65) received acupressure massage three times a week for 30 minutes on the sanyinjiao (SP6), ciliao (BL32), and taichong (Liver 3) acupoints. The control group (n = 64) received only a manual of menstrual health education without acupressure intervention. Data were collected at five time points: at baseline, 30 minutes, and 4, 8, and 12 months after the intervention. During the 12-month follow-up, the experimental group had significantly lower menstrual distress and LBP scores than the control group. Among 65 participants in the experimental group, 53 (82%) reported a moderate to high levels of menstrual distress, 51 (78%) reported moderate to high levels of LBP relief, and 49 (75%) reported moderate to high levels of satisfaction with acupressure. Our findings may serve as a reference for health care professionals and young women to improve self-care during menstruation and help further understand the therapeutic effects of acupressure on menstrual distress and LBP.

  8. Clinical experiences of Professor WU Bing-huang on emergency treatment with acuuressure%吴炳煌教授徒手急救法临床经验介绍

    Institute of Scientific and Technical Information of China (English)

    洪昆达; 万甜; 王林林; 吴明霞

    2011-01-01

    介绍吴炳煌教授徒手急救法的取穴及操作要点,内容包括昏迷急救法(虚脱、昏厥、血晕、晕针、晕灸或休克等),手法镇痛、镇咳止喘法(包括腹痛、呕吐、腹泻、头痛、牙痛、痛经、腰痛、落枕、咳嗽及哮喘等),并列举了典型病例.%The key points of acupoint selection and manipulations of Professor WU Bing-huang's experiences on emergency treatment with acupressure are introduced.It includes emergency treatment on coma (collapse, faint, faint at the sight of blood, faint during acupuncture, faint during moxibustion, shock, etc.), and pain, cough as well as asthma relieving with acupressure (include abdominal pain, vomiting, diarrhea, headache, toothache, dysmenorrhea, lumbago,neck stiffness after sleep, cough, asthma, etc.).At the same time, typical cases are given as examples.

  9. Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells.

    Science.gov (United States)

    Park, Sunwoo; Lim, Whasun; Bazer, Fuller W; Song, Gwonhwa

    2017-06-15

    Apigenin is a plant-derived flavonoid having antiproliferative, anti-inflammatory, and anti-angiogenic properties in chronic and metabolic diseases, and cancers. However, the functional role of apigenin remains to be identified in human endometriosis that is a benign inflammatory disease causing infertility, dysmenorrhea, dyspareunia, and chronic abdominal or pelvic pain. In the present study, we determined the effects of apigenin on two well-established human endometriosis cell lines (VK2/E6E7 and End1/E6E7). Apigenin reduced proliferation and induced cell cycle arrest and apoptosis in the both endometriosis cell lines. In addition, it disrupted mitochondrial membrane potential (MMP) which was accompanied by an increase in concentration of calcium ions in the cytosol and in pro-apoptotic proteins including Bax and cytochrome c in the VK2/E6E7 and End1/E6E7 cells. Moreover, apigenin treated cells accumulated excessive reactive oxygen species (ROS), and experienced lipid peroxidation and endoplasmic reticulum (ER) stress with activation of the unfolded protein response (UPR) regulatory proteins. Furthermore, the apigenin-induced apoptosis in endometriosis cells was regulated via the ERK1/2, JNK, and AKT cell signaling pathways. Taken together, apigenin is a potential novel therapeutic agent to overcome current limitations in the treatment to endometriosis. © 2017 Wiley Periodicals, Inc.

  10. Contraception and endometriosis: challenges, efficacy, and therapeutic importance

    Directory of Open Access Journals (Sweden)

    Weisberg E

    2015-07-01

    Full Text Available Edith Weisberg,1 Ian S Fraser2 1Family Planning NSW, 2School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia Abstract: Endometriosis is a benign gynecological condition that is estimated to affect 10% of women in the general population and appears to be increasing in incidence. It is an estrogen-dependent inflammatory disease, and is primarily characterized by dysmenorrhea, deep dyspareunia, chronic pelvic pain, and variable effects on fertility. The symptoms may greatly affect quality of life, and symptom control may be the primary aim of initial management, while contraceptive effect is often secondary. It is estimated that 30%–50% of women with endometriosis have an infertility problem, so a considerable number of endometriosis sufferers will require effective, planned contraception to maximize “protection of fertility” and prevent progression of the endometriotic condition. Ideally, this contraception should also provide symptom relief and improvement of physical, mental, and social well-being. At the present time, long-term progestogens appear to be the most effective choice for meeting all of these requirements, but other options need to be considered. It is becoming increasingly recognized that hormonal contraceptive systems are necessary for prevention of disease recurrence following surgical treatment of endometriosis. The personal preferences of the woman are an integral part of the final contraceptive choice. This article discusses the advantages and disadvantages of the contraceptive options available to women with endometriosis. Keywords: pelvic pain, disease recurrence, progestogens, delivery systems, long-acting

  11. Simultaneous determination of eleven major flavonoids in the pollen of Typha angustifolia by HPLC-PDA-MS.

    Science.gov (United States)

    Tao, Weiwei; Yang, Nianyun; Duan, Jin-ao; Wu, Dekang; Guo, Jianming; Tang, Yuping; Qian, Dawei; Zhu, Zhenhua

    2011-01-01

    The pollen of Typha angustifolia L. has been used for the treatment of dysmenorrhea, stranguria and metrorrhagia. Flavonoids are major active compounds in this pollen and their quantification is important for its quality control. To establish an HPLC-PDA-MS method for simultaneous determination of the 11 majority flavonoids in the pollen of T. angustifolia. The optimal condition of separation was achieved on a reversed-phase C₁₈ column with gradient elution of acetonitrile and 0.05% formic acid (v/v) at a flow-rate of 0.8 mL/min; the column temperature was set at 35 °C. All calibration curves showed good linear regression (r²  > 0.9992). The method provided good accuracy, precision, recovery and sensitivity for the quantification of the 11 compounds analysed. The HPLC method established is appropriate for the quality assurance of the pollen of T. angustifolia. Copyright © 2011 John Wiley & Sons, Ltd.

  12. Determination of nucleosides and nucleobases in the pollen of Typha angustifolia by UPLC-PDA-MS.

    Science.gov (United States)

    Tao, Wei-Wei; Duan, Jin-Ao; Yang, Nian-Yun; Guo, Sheng; Zhu, Zhen-Hua; Tang, Yu-Ping; Qian, Da-Wei

    2012-01-01

    The pollen of Typha angustifolia L. has been used traditionally for the treatment of dysmenorrhea, stranguria and metrorrhagia in China. Recently, nucleosides and nucleobases have been proven as important bioactive compounds. Exploration of the nucleoside and nucleobase profiles from the pollen of T. angustifolia is important for improving its therapeutic value and could be convenient for its quality evaluation. To establish an UPLC-PDA-MS method for simultaneous determination of nucleosides and nucleobases in the pollen of T. angustifolia. The analysis was performed on an Acuity UPLCHSS T3 column with a gradient elution of 5 mM ammonium acetate and methanol solution at a flow rate of 0.3 mL/min. Satisfactory separation of these compounds was obtained in less than 12 min. All calibration curves showed good linear regression (r²  > 0.9995). The method provided good accuracy, precision, recovery, and sensitivity for the quantification of the 10 compounds analysed. The UPLC method established is very helpful for optimising their content and could be convenient for quality evaluation of the pollen of T. angustifolia, which has not been reported as far as we are aware. Copyright © 2011 John Wiley & Sons, Ltd.

  13. Clinical significance of three-dimensional sonohysterography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Hye; Lee, Mi Hwa; Lee, Chan; Kim, Jong Wook; Shin, Myung Choel [Pochon Cha University College of Medicine, Pochon (Korea, Republic of)

    1999-12-15

    To evaluate the usefulness of three dimensional sonohysterography (3D SHG) in the evaluation of uterine endometrial and submucosal lesions in comparison with conventional two-dimensional sonohysterography (2D SHG). Our series consisted of 26 patients (mean aged 41 years) who complained of uterine bleeding, menorrhagia, or dysmenorrhea. 2D SHG was performed, and then 3D SHG was done after the volume mode was switched on. Simultaneous display of three perpendicular two-dimensional planes and surface rendering of findings on particular section were obtained. We analyzed whether the endometrium was thickened or not, and the location, size, shape, echogenicity, posterior shadowing, and echogenic rim of the focal lesion. The results were compared with the pathologic findings or MRI. There were submucosal myomas (n=12), intramural myomas (n=2), endometrial polyps (n=7), placental polyp (n=1), and normal endometrial cavities (n=4) on SHG. Nineteen cases were confirmed by pathologic findings or MRI. The results were correlated in 89% (17/19) of the cases. We misdiagnosed 2 cases: focal endometrial hyperplasia and choriocarcinoma were misdiagnosed as endometrial polyp and placental polyp, respectively. Imaging diagnoses were same in the techniques. Comparing with 2D SHG, 3D SHG provided a subjective display of pathologic findings and an additional information about spatial relationship between focal lesion and surroundings.

  14. The Evaluation Of Histopathological Diagnosis In Hysterectomy Materials

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    Cigdem Kunt isguder

    2016-06-01

    Results: The mean age of the patients was 50.48+/-7.50 (min:38, max:74. Leiomyoma with 77 case (%45.3 was the most hysterectomy indicated disease. Thereafter, dysfunctional uterine bleeding in 50 (%29.49, and endometrial hyperplasia 22 (%12.9 were detected. The other clinical indications were uterine prolapse in 17 patients (%10, chronic pelvic pain in 2 (%1.2 and adenomyosis in 2 (%1.2. The results of histopathological reports belong to hysterectomy materials indicated that leiomyoma was the most common pathological finding with 87 cases (%51.2, subsequently adenomyosis in 35 cases (% 20.5 and endometrial hyperplasia in 31 (18.3 was detected. Endometrial polyp was found in 10 cases (%5.9 and atrophic endometrium in 7 cases (%4.1. Combined pathology was defined in 44 hysteterctomy materials. Leiomyoma and endometrial hyperplasia were detected as the most common combination with a ratio of %50. In addition, chronic cervicitis was seen in %64.7 of cervical examinations of hysterectomy materials. Conclusion: Adenomyosis should be kept in mind while planning the diagnosis and treatment of patients whose admitted with compliants of menometrorrhagia, seconder dysmenorrhea and chronic pelvic pain in 4th and 5th decade. Endometrial sampling caused by the co-existence of leiomyoma and endometrial hyperplasia must be necessary in hysterectomy planned cases for leiomyoma those already have menometrorrhagia. [J Contemp Med 2016; 6(2.000: 87-91

  15. Review on Chronic Pelvic Inflammatory Disease Treated by Traditional Chinese Medicine%慢性盆腔炎中医药治疗概述

    Institute of Scientific and Technical Information of China (English)

    姬丽丽

    2012-01-01

    Chronic pelvic inflammatory disease is a common gynecological disease, frequently-occurring. The main clinical manifestations include lower abdominal pain, lumbosacral pain, leucorrhea increase, many accompanied by menstrual disorders, dysmenorrhea, sexual intercourse or defecation before and after pain and infertility. Many TCM therapy of chronic pelvic inflammatory disease are obviously effective, and have advantages. TCM treatment for chronic pelvic inflammatory disease has a broad developing prospect.%慢性盆腔炎是妇科常见病、多发病.临床主要表现为下腹部疼痛,腰骶部酸痛,带下增多,多伴有月经失调、痛经、性交或排便前后疼痛及不孕等症.慢性盆腔炎的中医药治疗方法较多,疗效明显,优势凸现,中医药治疗慢性盆腔炎具有广阔的发展前景.

  16. Clinical signs, symptoms and serum level of interleukin-6 and tumor necrosis factor in women with or without endometriosis

    Institute of Scientific and Technical Information of China (English)

    Wachyu Hadisaputra

    2013-01-01

    Objective: To evaluate clinical signs and symptoms and serum levels of interleukin-6 ( IL-6), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-2 (MMP-2), and vascular endothelial growth factor (VEGF) as non-invasive methods to diagnose endometriosis. Methods: Eighty women scheduled to laparoscopy underwent blood sampling for measurement of IL-6, TNF-α, MMP-2, and VEGF. The diagnosis of endometriosis was established by laparoscopy using The American Fertility Society visual diagnosis. The presence or absence of endometriosis was correlated with clinical signs and symptoms and with serum levels of those substances. Results:The sensitivity and specificity to detect endometriosis of infertility (OR 134.3) were 78 % and 98%, dysmenorrhoea (OR 11.7) were 63 % and 88 %, and chronic pelvic pain (OR 13.0) were 28 % and 100 %. The presence of rectovaginal nodules had a sensitivity 25 % and specificity 100 %. (OR 11.3, 95 %). The sensitivity and specificity of biologic markers IL-6 (OR 2.5) were 68 % and 53%, and TNF-α (OR 28.1) were 68% and 60 %. Conclusions: History of infertility, dysmenorrhea, chronic pelvic pain, dyspareunia, cervical tenderness and rectovaginal nodule are clinical signs and symptoms suggesting endometriosis. IL-6 and TNF-α appears to be best serum markers for endometriosis.

  17. Diagnosis, management, and long-term outcomes of rectovaginal endometriosis

    Directory of Open Access Journals (Sweden)

    Moawad NS

    2013-11-01

    Full Text Available Nash S Moawad,1 Andrea Caplin21Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, University of Florida, 2University of Florida College of Medicine, Gainesville, FL, USAAbstract: Rectovaginal endometriosis is the most severe form of endometriosis. Clinically, it presents with a number of symptoms including chronic pelvic pain, dysmenorrhea, deep dyspareunia, dyschezia, and rectal bleeding. The gold standard for diagnosis is laparoscopy with histological confirmation; however, there are a number of options for presurgical diagnosis, including clinical examination, transvaginal/transrectal ultrasound, magnetic resonance imagining, colonoscopy, and computed tomography colonography. Treatment can be medical or surgical. Medical therapies include birth control pills, oral progestins, gonadotropin-releasing hormone agonists, danazol, and injectable progestins. Analgesics are often used as well. Surgery improves up to 70% of symptoms. Surgery is either ablative or excisional, and is conducted via transvaginal, laparoscopic, laparotomy, or combined approaches. Common surgical techniques involve shaving of the superficial rectal lesion, laparoscopic anterior discoid resection, and low anterior bowel resection and reanastomosis. Outcomes are generally favorable, but postoperative complications may include intra-abdominal bleeding, anastomotic leaks, rectovaginal fistulas, strictures, chronic constipation, and the need for reoperation. Recurrence of rectal endometriosis is a possibility as well. Other outcomes are improved pain-related symptoms and fertility. Long-term outcomes vary according to the management strategy used. This review will provide the most recent approaches and techniques for the diagnosis and treatment of rectovaginal endometriosis.Keywords: pelvic pain, dyspareunia, bowel resection, endometriosis, rectovaginal

  18. Safety, efficacy and patient acceptability of the combined estrogen and progestin transdermal contraceptive patch: a review

    Directory of Open Access Journals (Sweden)

    Alessandra Graziottin

    2008-11-01

    Full Text Available Alessandra GraziottinCenter of Gynecology and Medical Sexology, H San Raffaele Resnati, Via Santa Croce 10/a, 20123 Milano, ItalyAbstract: The worldwide introduction of the first, unique patch for hormonal contraception (ethinyl estradiol/norelgestromin, EE/NGMN patch was widely recognized as a significant event in the development of drug delivery systems. This innovation offers a number of advantages over the oral route, and extensive clinical trials have proved its safety, efficacy, effectiveness, and tolerability. The weekly administration and ease of use/simplicity of the EE/NGMN patch contribute to its acceptability, and help to resolve the two main problems of non-adherence, namely early discontinuation and inconsistent use. The patch offers additional benefits to adolescents (improvement of dysmenorrhea and acne, adults (improvement in emotional and physical well-being, premenstrual syndrome, and menstrual irregularities, and perimenopausal women (correction of hormonal imbalance, modulation of premenopausal symptoms, thus providing high satisfaction rates (in nearly 90% of users. Since its introduction, the transdermal contraceptive patch has proved to be a useful choice for women who seek a convenient formulation which is easy to use, with additional, non-contraceptive tailored benefits for all the ages.Keywords: transdermal, hormonal contraceptive, patient satisfaction, patient adherence

  19. EVALUATION OF NURSING STUDENTS' PREMENSTRUAL SYMPTOMS

    Directory of Open Access Journals (Sweden)

    Kerime Derya TASCI

    2006-12-01

    Full Text Available This study was conducted as a descriptive study for the purpose of determining the kinds of premenstrual symptoms that Denizli Health Sciences School Nursing Students experience and what they do to treat them. The research population included the 126 female students in the Pamukkale University Denizli Health Sciences School Nursing School. Data collects in the classroom. In the examination of the students' menstrual complaints, 47.5% experienced back pain, 59% experienced abdominal pain, 44.3% experienced irritability, 39.3% experienced breast sensitivity/pain, 41% experienced facial or body acne and 32.8% experienced increased appetite every cycle. An examination of the students' responses about procedures during menstruation, 86.9% stated that having a bath was not contraindicated and 60.7% that aspirin-type analgesics should not be used for dysmenorrhea. 77.9% of the students stated that it was normal to have pain during menstruation and 63.9% that walking is beneficial for decreasing menstrual pain. There was a significant difference in the students' answers based on age group and class for experience of menstrual complaints and procedures used (p<0.05. The students' were lived premenstrual symptoms and they had insufficient knowledge of procedures for relief. [TAF Prev Med Bull 2006; 5(6.000: 434-443

  20. Safety, efficacy and patient acceptability of the contraceptive and non-contraceptive uses of the LNG-IUS.

    Science.gov (United States)

    Bednarek, Paula H; Jensen, Jeffrey T

    2010-08-09

    Intrauterine devices (IUDs) provide highly effective, long-term, safe, reversible contraception, and are the most widely used reversible contraceptive method worldwide. The levonorgestrel-releasing intrauterine system (LNG-IUS) is a T-shaped IUD with a steroid reservoir containing 52 mg of levonorgestrel that is released at an initial rate of 20 μg daily. It is highly effective, with a typical-use first year pregnancy rate of 0.1% - similar to surgical tubal occlusion. It is approved for 5 years of contraceptive use, and there is evidence that it can be effective for up to 7 years of continuous use. After removal, there is rapid return to fertility, with 1-year life-table pregnancy rates of 89 per 100 for women less than 30 years of age. Most users experience a dramatic reduction in menstrual bleeding, and about 15% to 20% of women become amenorrheic 1 year after insertion. The device's strong local effects on the endometrium benefit women with various benign gynecological conditions such as menorrhagia, dysmenorrhea, leiomyomata, adenomyosis, and endometriosis. There is also evidence to support its role in endometrial protection during postmenopausal estrogen replacement therapy, and in the treatment of endometrial hyperplasia.

  1. Emerging indications for the levonorgestrel-releasing intrauterine system (LNG-IUS).

    Science.gov (United States)

    Heikinheimo, Oskari; Gemzell-Danielsson, Kristina

    2012-01-01

    The levonorgestrel intrauterine system (LNG-IUS), originally designed for long-term contraceptive use, has been on the Scandinavian market for approximately 20 years. Novel clinical indications for the LNG-IUS, derived mainly from investigator-initiated studies, are emerging. These include heavy menstrual bleeding associated with uterine fibroids, endometriosis, adenomyosis, as well as endometrial hyperplasia. In both cohort and randomized studies, the LNG-IUS is effective in decreasing heavy menstrual bleeding, also in women diagnosed with uterine fibroids. In randomized studies the LNG-IUS has shown comparable clinical efficacy to GnRH analogues or progestins for the symptomatic treatment of endometriosis. Experience with LNG-IUS in adenomyosis is based on prospective cohort studies. Dysmenorrhea has been reported to decrease in all women, and uterine volume was seen to diminish in some of these studies. In the treatment of endometrial hyperplasias, including atypical hyperplasia, the LNG-IUS is equal or superior to treatment with systemic progestins. Further studies are needed to examine the full potential of the LNG-IUS in such common clinical situations.

  2. Integrative treatment in endometriosis

    Institute of Scientific and Technical Information of China (English)

    Yu Jin; Yu Chao-qin

    2006-01-01

    Objective: To study the effectiveness of Yu's Neiyi Recipe on endometriosis.Methods: Yu's Neiyi Recipe was administrated in 48 patients with endometriosis (including 20 infertile cases). The clinical manifestations, ultrasonography, basal body temperature (BBT) and hormonal levels were observed before and 3 months after the treatment. The pregnancy outcome was followed up within 2 years.Results: Efficacy of Yu's Neiyi Recipe in the 48 cases was 93.75% within 3 months of treatment, 15 of the 20 infertile women become pregnant (80%) within 2 years. After the treatment, scores of dysmenorrhea, chronic pelvic pain or dyspareunia, and the size of ovarian endometrioma obviously decreased (P<0.01, P<0.01, P<0.01), meanwhile, the BBT type and high phase score (HPS) significantly improved (P<0.05). During herbal treatment, serum high PRL levels significantly dropped (P<0.05), and serum LH and E2 levels elevated significantly (P<0.05).Conclusions: Yu's Neiyi Recipe not only relieves the symptoms and signs of patients with endometriosis significantly, but also shows a good regulation on patients' ovarian function to improve the rate of ovulation and pregnancy.

  3. Potential of Essential Oils as Penetration Enhancers for Transdermal Administration of Ibuprofen to Treat Dysmenorrhoea

    Directory of Open Access Journals (Sweden)

    Jun Chen

    2015-10-01

    Full Text Available The present study was conducted to evaluate and compare five essential oils (EOs as penetration enhancers (PEs to improve the transdermal drug delivery (TDD of ibuprofen to treat dysmenorrhoea. The EOs were prepared using the steam distillation method and their chemical compositions were identified by GC-MS. The corresponding cytotoxicities were evaluated in epidermal keartinocyte HaCaT cell lines by an MTT assay. Furthermore, the percutaneous permeation studies were carried out to compare the permeation enhancement effect of EOs. Then the therapeutic efficacy of ibuprofen with EOs was evaluated using dysmenorrheal model mice. The data supports a decreasing trend of skin cell viability in which Clove oil >Angelica oil > Chuanxiong oil > Cyperus oil > Cinnamon oil >> Azone. Chuanxiong oil and Angelica oil had been proved to possess a significant permeation enhancement for TDD of ibuprofen. More importantly, the pain inhibitory intensity of ibuprofen hydrogel was demonstrated to be greater with Chuanxiong oil when compared to ibuprofen without EOs (p < 0.05. The contents of calcium ion and nitric oxide (NO were also significantly changed after the addition of Chuanxiong oil (p < 0.05. In summary, we suggest that Chuanxiong oil should be viewed as the best PE for TDD of ibuprofen to treat dysmenorrhea.

  4. Non-contraceptive benefits of oral contraceptives

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    Dhont M

    2011-10-01

    Full Text Available Marc Dhont Department of Obstetrics and Gynecology, Ghent University Hospital, Ghent, Belgium Abstract: The health benefits of the oral contraceptive (OC pill are numerous and outweigh the risks of OC use. There are unintended but useful preventive side effects and potential therapeutic uses of OCs apart from contraception itself. Unequivocal evidence for the protective influence of combined OCs against ovarian and endometrial cancers, and colon cancer to a lesser extent, has been found. The pill also reduces the incidence of benign breast disease, functional ovarian cysts, pelvic inflammatory disease requiring hospitalization, ectopic pregnancy, and iron-deficiency anemia. The pill can be used for the treatment of several gynecologic disorders such as dysmenorrhea, irregular or excessive bleeding, acne, hirsutism, and endometriosis-associated pain, whether prescribed solely to treat these symptoms or prescribed to treat them in addition to providing contraception. These health benefits are often underestimated, as they get too little attention from the mass media. Keywords: the pill, estrogens, progestogens, safety, contraception

  5. The effects of Crocus sativus (saffron and its constituents on nervous system: A review

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    Mohammad Reza Khazdair

    2015-08-01

    Full Text Available Saffron or Crocus sativus L. (C. sativus has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50 of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of disorders including coronary artery diseases, hypertension, stomach disorders, dysmenorrhea and learning and memory impairments. In addition, different studies have indicated that saffron has anti-inflammatory, anti-atherosclerotic, antigenotoxic and cytotoxic activities. Antitussive effects of stigmas and petals of C. sativus and its components, safranal and crocin have also been demonstrated. The anticonvulsant and anti-Alzheimer properties of saffron extract were shown in human and animal studies. The efficacy of C. sativus in the treatment of mild to moderate depression was also reported in clinical trial. Administration of C. sativus and its constituents increased glutamate and dopamine levels in the brain in a dose-dependent manner. It also interacts with the opioid system to reduce withdrawal syndrome. Therefore, in the present article, the effects of C. sativus and its constituents on the nervous system and the possible underlying mechanisms are reviewed. Our literature review showed that C. sativus and its components can be considered as promising agents in the treatment of nervous system disorders.

  6. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review.

    Science.gov (United States)

    Khazdair, Mohammad Reza; Boskabady, Mohammad Hossein; Hosseini, Mahmoud; Rezaee, Ramin; M Tsatsakis, Aristidis

    2015-01-01

    Saffron or Crocus sativus L. (C. sativus) has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50) of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of disorders including coronary artery diseases, hypertension, stomach disorders, dysmenorrhea and learning and memory impairments. In addition, different studies have indicated that saffron has anti-inflammatory, anti-atherosclerotic, antigenotoxic and cytotoxic activities. Antitussive effects of stigmas and petals of C. sativus and its components, safranal and crocin have also been demonstrated. The anticonvulsant and anti-Alzheimer properties of saffron extract were shown in human and animal studies. The efficacy of C. sativus in the treatment of mild to moderate depression was also reported in clinical trial. Administration of C. sativus and its constituents increased glutamate and dopamine levels in the brain in a dose-dependent manner. It also interacts with the opioid system to reduce withdrawal syndrome. Therefore, in the present article, the effects of C. sativus and its constituents on the nervous system and the possible underlying mechanisms are reviewed. Our literature review showed that C. sativus and its components can be considered as promising agents in the treatment of nervous system disorders.

  7. Synthetic Hormones and Clot Formation.

    Science.gov (United States)

    Swanepoel, Albe C; Visagie, Amcois; Pretorius, Etheresia

    2016-08-01

    Combined oral contraceptives (COCs), colloquially referred to as "the pill," have been regarded as a medical breakthrough, as they have improved the lives of countless women, from simplifying family planning to the treatment of acne, endometriosis, polycystic ovarian syndrome, and dysmenorrhea. Unfortunately, COC usage has been associated with an increased occurrence of venous thrombosis and therefore a systemic hypercoagulable state in susceptible females. Here we discuss the health risks of COC usage and use viscoelastic and morphological techniques to investigate the effect of different COC constituents on clot formation, particularly fibrin network packaging and whole blood viscoelasticity. Viscoelastic properties of whole blood showed gender-specific changes while morphological alterations were person-specific, regardless of gender. Using scanning electron microscopy and thromboelastography provides great insight regarding fibrin packaging and the development of a hypercoagulable state in high-risk individuals. We proposed a three-step approach where (1) an individual's coagulation profile baseline is determined, after which (2) the "ideal" combination of constituents is prescribed, and (3) the coagulation profile of the individual is monitored to assess possible risk of thrombosis. Only in following such an individualized patient-oriented approach will we be able to avoid the many health issues due to COC usage in susceptible females.

  8. The Effect of Acupuncture to SP6 on Skin Temperature Changes of SP6 and SP10: An Observation of “Deqi”

    Directory of Open Access Journals (Sweden)

    Jia-Min Yang

    2014-01-01

    Full Text Available Background. Deqi sensation is a complex but an important component for acupuncture effect. In this study, we tried to observe the relationship between Deqi and skin temperature changes and whether there was some relativity between Deqi and needle stimulations on cold congealing and dysmenorrhea rat model. Thirty-two female Sprague Dawley (SD rats were randomly divided into four groups (Saline Control Group, Model Group, Group A with strong stimulation, and Group B with small stimulation. Group A and Group B were performed with different stimulations. We found that, compared with saline control group, model group, and Group B, Group A showed that the skin temperature changes on right acupoint SP6 and SP10 increased significantly at 5 min–10 min interval. The skin temperature changes on left SP6 decreased at instant–5 min interval. The skin temperature changes on right SP10 decreased significantly at instant–5 min interval and 10 min–20 min interval. Thermogenic action along Spleen Meridian of Foot Greater Yin was manifested as simultaneous skin temperature increase on right SP6 and SP10 at 5 min–10 min interval after needling SP6, which was helpful to illustrate the relationship between the characteristic of Deqi and needle stimulations.

  9. The Effect of Acupuncture to SP6 on Skin Temperature Changes of SP6 and SP10: An Observation of "Deqi".

    Science.gov (United States)

    Yang, Jia-Min; Shen, Xiao-Yu; Zhang, Ling; Shen, Song-Xi; Qi, Dan-Dan; Zhu, Shi-Peng; Luo, Li; Ren, Xiao-Xuan; Ji, Bo; Zhang, Lu-Fen; Li, Xiao-Hong; Zhu, Jiang

    2014-01-01

    Background. Deqi sensation is a complex but an important component for acupuncture effect. In this study, we tried to observe the relationship between Deqi and skin temperature changes and whether there was some relativity between Deqi and needle stimulations on cold congealing and dysmenorrhea rat model. Thirty-two female Sprague Dawley (SD) rats were randomly divided into four groups (Saline Control Group, Model Group, Group A with strong stimulation, and Group B with small stimulation). Group A and Group B were performed with different stimulations. We found that, compared with saline control group, model group, and Group B, Group A showed that the skin temperature changes on right acupoint SP6 and SP10 increased significantly at 5 min-10 min interval. The skin temperature changes on left SP6 decreased at instant-5 min interval. The skin temperature changes on right SP10 decreased significantly at instant-5 min interval and 10 min-20 min interval. Thermogenic action along Spleen Meridian of Foot Greater Yin was manifested as simultaneous skin temperature increase on right SP6 and SP10 at 5 min-10 min interval after needling SP6, which was helpful to illustrate the relationship between the characteristic of Deqi and needle stimulations.

  10. The Effect of Acupuncture to SP6 on Skin Temperature Changes of SP6 and SP10: An Observation of “Deqi”

    Science.gov (United States)

    Yang, Jia-Min; Shen, Xiao-Yu; Shen, Song-Xi; Qi, Dan-Dan; Luo, Li; Ren, Xiao-Xuan; Ji, Bo; Zhang, Lu-Fen; Li, Xiao-Hong; Zhu, Jiang

    2014-01-01

    Background. Deqi sensation is a complex but an important component for acupuncture effect. In this study, we tried to observe the relationship between Deqi and skin temperature changes and whether there was some relativity between Deqi and needle stimulations on cold congealing and dysmenorrhea rat model. Thirty-two female Sprague Dawley (SD) rats were randomly divided into four groups (Saline Control Group, Model Group, Group A with strong stimulation, and Group B with small stimulation). Group A and Group B were performed with different stimulations. We found that, compared with saline control group, model group, and Group B, Group A showed that the skin temperature changes on right acupoint SP6 and SP10 increased significantly at 5 min–10 min interval. The skin temperature changes on left SP6 decreased at instant–5 min interval. The skin temperature changes on right SP10 decreased significantly at instant–5 min interval and 10 min–20 min interval. Thermogenic action along Spleen Meridian of Foot Greater Yin was manifested as simultaneous skin temperature increase on right SP6 and SP10 at 5 min–10 min interval after needling SP6, which was helpful to illustrate the relationship between the characteristic of Deqi and needle stimulations. PMID:24665334

  11. Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density.

    Science.gov (United States)

    Carr, Bruce; Dmowski, W Paul; O'Brien, Chris; Jiang, Ping; Burke, Joshua; Jimenez, Roland; Garner, Elizabeth; Chwalisz, Kristof

    2014-11-01

    This randomized double-blind study, with 24-week treatment and 24-week posttreatment periods, evaluated the effects of elagolix (150 mg every day, 75 mg twice a day) versus subcutaneous depot medroxyprogesterone acetate (DMPA-SC) on bone mineral density (BMD), in women with endometriosis-associated pain (n = 252). All treatments induced minimal mean changes from baseline in BMD at week 24 (elagolix 150 mg: -0.11%/-0.47%, elagolix 75 mg: -1.29%/-1.2%, and DMPA-SC: 0.99%/-1.29% in the spine and total hip, respectively), with similar or less changes at week 48 (posttreatment). Elagolix was associated with improvements in endometriosis-associated pain, assessed with composite pelvic signs and symptoms score (CPSSS) and visual analogue scale, including statistical noninferiority to DMPA-SC in dysmenorrhea and nonmenstrual pelvic pain components of the CPSSS. The most common adverse events (AEs) in elagolix groups were headache, nausea, and nasopharyngitis, whereas the most common AEs in the DMPA-SC group were headache, nausea, upper respiratory tract infection, and mood swings. This study showed that similar to DMPA-SC, elagolix treatment had minimal impact on BMD over a 24-week period and demonstrated similar efficacy on endometriosis-associated pain. © The Author(s) 2014.

  12. Chiropractic adjustment in the management of visceral conditions: a critical appraisal.

    Science.gov (United States)

    Jamison, J R; McEwen, A P; Thomas, S J

    1992-01-01

    To establish whether Australian chiropractors regard spinal adjustment as an intervention option for patients presenting with visceral conditions and to ascertain the preferred level of adjustment for patients presenting with migraine, asthma, hypertension or dysmenorrhea. A survey of all chiropractors registered in Australia. Practitioners' opinions regarding the usefulness of spinal adjustment in the management of patients with visceral conditions were canvassed. Based upon their personal clinical experience, practitioners were requested to comment on the appropriate level of adjustment in the management of various visceral conditions. Twenty-two percent of the 1311 chiropractors registered in Australia responded to the survey. More than half of the respondents favored a role for spinal adjustment in the management of patients with visceral conditions. The perceived usefulness of spinal adjustment varied according to the condition being managed, as did the preferred level of adjustment. Chiropractors continue to use spinal adjustment in the management of visceral conditions despite this intervention being regarded as an obstacle to the recommendation of public finding for chiropractic services in Australia. Further investigation into the validity of the chiropractic management of visceral conditions is recommended.

  13. Ibuprofen versus steroids: risk and benefit, efficacy and safety

    Directory of Open Access Journals (Sweden)

    M. Giovannini

    2013-10-01

    Full Text Available In the last few years we have observed an upward trend in the employment of ibuprofen as anti-inflammatory and antipyretic therapy. Therefore the pediatrician has often a precious option in the anti-inflammatory and antipyretic treatment in children instead of using steroids and paracetamol. In clinical practice ibuprofen can be used in the treatment of headache, toothache, otalgy, dysmenorrhea, neuralgia, arthralgia, myalgia, abdominal pain and fever: it is the first choice for these common diseases. However, the use of steroids is a routine, even if non-corticosteroid anti-inflammatory molecules could be useful. Certainly steroids are powerful anti-inflammatory, indicated for the treatment of chronic inflammatory disorders and in acute respiratory and allergic diseases. Beside, thanks to their chemical and pharmacological profile, they also provide patients with an antipyretic effect. However, the use of steroids must be reserved to cases in which other classical antipyretics such as non-steroidal anti-inflammatory drugs are not effective. The possible side effects and risks associated with stepping down steroids must be considered. Although “steroids-phobia” should be discouraged, steroids are to be reserved only as the first indication. In all other cases the pediatrician can use ibuprofen, whose efficacy and safety are widely demonstrated by now.

  14. Vitamin D and female fertility.

    Science.gov (United States)

    Lerchbaum, Elisabeth; Rabe, Thomas

    2014-06-01

    Apart from the well known effects of vitamin D on maintaining calcium homeostasis and promoting bone mineralization, there is some evidence suggesting that vitamin D also modulates human reproductive processes. We will review the most interesting and relevant studies on vitamin D and female fertility published over the past year. In the past year, several observational studies reported a better in-vitro fertilization outcome in women with sufficient vitamin D levels (≥30 ng/ml), which was mainly attributed to vitamin D effects on the endometrium. One randomized controlled trial found an increased endometrial thickness in women with polycystic ovary syndrome (PCOS) receiving vitamin D during intrauterine insemination cycles. Further, vitamin D supplementation had a beneficial effect on serum lipids in PCOS women. Vitamin D treatment improved endometriosis in a rat model and increased vitamin D intake was related to a decreased risk of incident endometriosis. Vitamin D was also favorably associated with primary dysmenorrhea, uterine leiomyoma, and ovarian reserve in late reproductive aged women. In women undergoing in-vitro fertilization, a sufficient vitamin D level (≥30 ng/ml) should be obtained. Vitamin D supplementation might improve metabolic parameters in women with PCOS. A high vitamin D intake might be protective against endometriosis.

  15. Laparascopic ventrosuspension in infertile patients. A new technique.

    Science.gov (United States)

    Serour, G I; Hefnawi, F

    1981-01-01

    This paper describes the application of the Falope-Ring via laparascopy to the round ligaments in 86 infertile patients, for correction of retroversion of the uterus. Diagnostic laparascopy was performed on 2600 cases of infertility at Al-Azhar University Teaching Hospitals during a 3-year period. Laparascopy was performed as a primary mehtod of investigation of infertility, after clinical examination and semen analysis in 866 patients. These included long term cases of infertility, late marriage and cases where pelvic pathology was suspected on clinical grounds. Laparascopy was used as a final line of investigation of infertility in 1734 patients. In 86 patients with retroverted uterus as the only abnormality deteched, ventrosuspension was performed via the laparascope, by applying Falope-Rings to the round ligaments. These patients were followed up for periods varying from 6 months to 2 years. Pregnancy occurred in 24 patients and improvement of backache, deep dysparunea, congestive dysmenorrhea and leukorrhea occurred in 88.37%, 83.72%, 72.05% and 68.76%, respectively. The technique described in this paper is simple, easy to learn, can be performed under general or local anesthesia and is performed during the laparascopic investigation of the infertile cases and thus does not add an extra risk of operation or cost to the patient.

  16. Uptake and continuous use of copper intrauterine device in a cohort of HIV-positive women.

    Science.gov (United States)

    Landolt, Nadia Kancheva; Phanuphak, Nittaya; Teeratakulpisarn, Nipat; Kriengsinyot, Rosalin; Ahluwalia, Jennisa; Pinyakorn, Suteeraporn; Chaithongwongwatthana, Surasith; Ananworanich, Jintanat

    2013-01-01

    Copper intrauterine device (IUD) is not commonly used in many countries, though it provides effective reversible contraception with no or minimal primary systemic side effects. We assessed its uptake and continuation of use among HIV-positive Thai women. Sixty-six of 322 women of reproductive age, whom we approached for the study, met the eligibility criteria. Sterilization (62%) was the main reason for failure to enroll. Twenty-nine of them (44%) underwent IUD insertion. Considering condom use sufficient for pregnancy prevention (12%) was the main reason among eligible women for the refusal to participate in the study. At six months, 54% of enrolled participants reported one or more side effects such as increased menstrual flow (43%), spotting (21%) and dysmenorrhea (11%). The continuation rate of IUD use was high (93%), in spite of the persistent non-systemic side effects. The study showed that copper IUD could be an acceptable contraceptive choice for Thai HIV-positive women. Easy access to the method in a setting linked with the HIV service, and education on IUD risks and benefits is needed to promote the use of IUD in addition to condoms as an effective contraceptive option in HIV-infected women.

  17. Understanding benefits and addressing misperceptions and barriers to intrauterine device access among populations in the United States

    Directory of Open Access Journals (Sweden)

    Yoost J

    2014-07-01

    Full Text Available Jennie Yoost Marshall University Department of Obstetrics and Gynecology, Huntington, WV, USA Abstract: Three intrauterine devices (IUDs, one copper and two containing the progestin levonorgestrel, are available for use in the United States. IUDs offer higher rates of contraceptive efficacy than nonlong-acting methods, and several studies have demonstrated higher satisfaction rates and continuation rates of any birth control method. This efficacy is not affected by age or parity. The safety of IUDs is well studied, and the risks of pelvic inflammatory disease, perforation, expulsion, and ectopic pregnancy are all of very low incidence. Noncontraceptive benefits include decreased menstrual blood loss, improved dysmenorrhea, improved pelvic pain associated with endometriosis, and protection of the endometrium from hyperplasia. The use of IUDs is accepted in patients with multiple medical problems who may have contraindications to other birth control methods. Yet despite well-published data, concerns and misperceptions still persist, especially among younger populations and nulliparous women. Medical governing bodies advocate for use of IUDs in these populations, as safety and efficacy is unchanged, and IUDs have been shown to decrease unintended pregnancies. Dispersion of accurate information among patients and practitioners is needed to further increase the acceptability and use of IUDs. Keywords: IUD, contraception, levonorgestrel, copper

  18. Long-term safety, efficacy, and patient acceptability of the intrauterine Copper T-380A contraceptive device

    Directory of Open Access Journals (Sweden)

    Bliss Kaneshiro

    2010-07-01

    Full Text Available Bliss Kaneshiro, Tod AebyDepartment of Obstetrics and Gynecology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USAAbstract: The intrauterine device (IUD, primarily in the form of the copper IUD, is used by more than 150 million women around the world, making it the most widely used reversible method of contraception. With a remarkably low failure rate of less than 1 per 100 women in the first year of use, the Copper T-380A is in the top tier of contraceptives in terms of efficacy. Risks of utilization include perforation and an increased risk of infection in the first 20 days following insertion. Overall, the number of adverse events is low, making the Copper T-380A a very safe contraceptive method. The most common reasons for the discontinuation of this method are menstrual bleeding and dysmenorrhea. However, cumulative discontinuation rates of Copper T-380A are lower than that have been reported for other methods, indicating that the Copper T-380A is highly acceptable to women. After 5 years, approximately 50% of all women, who have a Copper T-380A inserted, will continue to use this highly effective contraceptive method.Keywords: contraception, perforation, expulsion, pelvic inflammatory disease, continuation

  19. 促性腺激素释放激素激动剂联合左炔诺孕酮宫内缓释系统治疗子宫腺肌病的疗效观察%Effect of GnRH-a combined with levonorgestrel-releasing intrauterine system on the treatment of large adenomyosis

    Institute of Scientific and Technical Information of China (English)

    刘芸; 段华

    2014-01-01

    目的:探讨促性腺激素释放激素激动剂(GnRH-a)联合左炔诺孕酮宫内缓释系统(LNG-IUS)治疗较大子宫腺肌病的效果。方法入选子宫腺肌病所致中、重度痛经合并月经量过多的患者54例,宫腔深度9~12 cm, GnRH-a治疗3个疗程后放置LNG-IUS,比较治疗前,放置后3个月、6个月、12个月患者的痛经缓解程度、子宫体积变化、血红蛋白及血清CA125水平。结果47例完成研究,患者痛经的VAS评分由治疗前的(75.9±10.3)下降为治疗后的(27.1±8.6),VRS评分由(2.2±0.4)分下降为(1.1±0.2)分,子宫体积由(268.2±12.0)cm3下降为(196.3±7.2)cm3,血清CA125水平由(68.2±22.2)U/ml下降为(43.4±22.1)U/ml,血红蛋白由(87.4±10.3)g/L上升为(123.9±23.1)g/L,差异均有统计学意义(P<0.01)。且上述指标在弥漫性和局限性子宫腺肌病均有明显改善。结论 GnRH-a联合LNG-IUS治疗宫腔深度在9~12 cm的子宫腺肌病,近期内能有效缓解痛经及月经量过多的临床症状,短期内避免手术治疗可能带来的相关风险,提高生活质量,值得临床应用。但对于局限性子宫腺肌病的患者使用前应与患者充分沟通,密切随访,观察疗效,适时修改治疗方案。%Objective To evaluate the effect of gonadotropin releasing hormone agonist (GnRH-a) combined with levonorgestrel-releasing intrauterine system (LNG-IUS) on the treatment of large adenomyosis. Methods Fifty-four women with moderate or severe dysmenorrhea associated with adenomyosis were recruited, whose depth of uterine cavity was from 9 to 12 cm. All women were inserted LNG-IUS following 3 courses of GnRH-a. Three, six and twelve months af-ter the placement of LNG-IUS, the uterine size, degree of dysmenorrhea, hemoglobin and CA 125 values were compared to those before therapy. Results Forty-seven women completed the study. There were significant differences between

  20. [Experience with the copper intrauterine device cu-7 (authors transl)].

    Science.gov (United States)

    Erb, H

    1976-08-10

    The effectiveness and tolerability of the Copper-7 IUD were studied in a private medical practice by performing insertions for 103 women, 20-48 years of age. Hysteronometric measurements before the study excluded women with a fundus uteri depth less than 5.5 cm, those with severely ante- or retroflected uterus, and those with myoma uteri or double uterus. For women after uteronomy, insertion was performed at least 6 months later. Follow-up rate, with regular check-ups during a total of 1280 cycles, was 100%. The total failure rate, or Pearl Index, was 1% (1 pregnancy). There were 4 (3.9%) expulsions, and 8 (7.8%) removals for medical reasons including 1 for metritis, 2 for bleeding, and 3 for pain and cramps. The continuation rate, after 1 year of use, was 87%. The ensure optimal contraceptive effect, as well as toleration of the CU-7, potential users should be carefully measured for adequate size of the uterine cavity. Consistent follow-up and personal contact with the physician are very important. This reversible contraceptive method is highly recommended for any women with a normal uterus who does not suffer from dysmenorrhea.

  1. Preparation, Characterization and Pharmacokinetic Study of Xiangfu Siwu Decoction Essential Oil/β-Cyclodextrin Inclusion Complex

    Directory of Open Access Journals (Sweden)

    Junzuan Xi

    2015-06-01

    Full Text Available Xiang-Fu-Si-Wu Decoction (XFSWD, a famous Chinese herbal formula, is considered an effective prescription for treating primary dysmenorrhea. The essential oil is a significant effective ingredient of XFSWD. However, its volatility, instability and poor water-solubility influence its pharmacodynamic effects. β-Cyclodextrin (β-CD has the intrinsic ability to form specific inclusion complexes with such drugs to enhance their stability, solubility and bioavailability. The aim of this study was thus to compare the pharmacokinetic characteristics and the oral bioavailability of XFSWD essential oil (XEO and its β-CD inclusion complex after oral administration to rats. A simple, rapid, and sensitive ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS method was developed for the simultaneous quantification of five active components of XEO in rat plasma. The in vivo data showed that XEO/β-CD inclusion complex displayed higher maximum plasma concentration (Cmax, longer half-time (T1/2 and bigger area under the concentration-time curve (AUC0–24 h. These results demonstrated that the formation of β-CD inclusion complex has significantly increased the oral bioavailability of the drugs in rats than free oil.

  2. Induced Abortion and the Risk of Tubal Infertility

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To explore the association between induced abortion and tubal infertility in Chengdu, China.Methods A 1 :2 case-control study was designed. Infertile women with bilateral tubal occlusion in the case group compared with two control groups: infertile control group with bilateral tubal patency and pregnant control group with currently pregnancy. Data were collected using questionnaires through face-to-face interviews, covering the subjects' demographic details and histories of gynecology and obstetrics. Adjusted odds ratio was calculated as a measure of the association using stepwise multiple logistic regression analysis.Results Induced abortion was not found to be associated with tubal infertility in the analysis including either the infertile controls or the pregnant controls, but other risk factors were found, such as history of acute pelvic inflammatory disease (PID), lower abdominal surgeries, dysmenorrhea and pregnancy.Conclusion It is contended that facing an increasing trend of infertile cases with tubal occlusion in China, it is emphasized that special attention should paid to the long term impact of reproductive tract infection, especially, asymptomatic ones, rather than induced abortion.

  3. Patient selection guidelines in MR-guided focused ultrasound surgery of uterine fibroids: a pictorial guide to relevant findings in screening pelvic MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang-Wook; Kim, Kyoung Ah [Pochon CHA University Bundang CHA General Hospital, Department of Diagnostic Radiology, College of Medicine, Gyunggi-do (Korea); Lee, Chan; Na, Young-Jeong; Jung, Sang-Geun; Kim, Seung-Jo [Pochon CHA University Bundang CHA General Hospital, Comprehensive Gynecologic Cancer Center, College of Medicine, Gyunggi-do (Korea); Cha, Sun Hee [Pochon CHA University Bundang CHA General Hospital, Department of Obstetrics and Gynecology, College of Medicine, Gyunggi-do (Korea); Yu, Jeong-Sik [YongDong Severance Hospital, Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul (Korea)

    2008-12-15

    Uterine leiomyomas (fibroids), the most common benign tumor in women of childbearing age, can cause symptoms including dysmenorrhea, menorrhagia, urinary symptoms, pain and infertility. Hysterectomy is a common approach to treating uterine fibroids, and less invasive surgical approaches such as myomectomy and uterine artery embolization also have been shown to alleviate symptoms. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is the only totally non-invasive surgical approved method for treating uterine fibroids. In clinical trials, MRgFUS resulted in significant relief of uterine fibroid symptoms. The safe and effective use of MRgFUS is affected by fibroid type and location, position relative to adjacent anatomical structures and the presence of co-existent pelvic disease. Additionally, successful outcomes with MRgFUS have been correlated with the volume of fibroids ablated during the procedure. Thus, selection of patients in whom sufficient fibroid volumes can be treated safely using the MRgFUS system is critical for successful outcomes. The MR images in this pictorial essay provide examples of uterine fibroids for which MRgFUS should be considered and is designed to facilitate the selection of patients for whom MRgFUS is most likely to provide sustained symptom relief. (orig.)

  4. Induction of human leukemia U937 cell apoptosis by an ethanol extract of Dendropanax morbifera Lev. through the caspase-dependent pathway.

    Science.gov (United States)

    Lee, Joon Wοο; Park, Cheol; Han, Min Hο; Hong, Su Hyun; Lee, Tae Kyung; Lee, Shin Hwa; Kim, Gi-Young; Choi, Yung Hyun

    2013-09-01

    Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not yet been clearly elucidated. In the present study, we investigated the pro-apoptotic effects of an ethanol extract of D. morbifera stem bark (EEDM) on human leukemia U937 cells. EEDM markedly inhibited the growth of U937 cells by decreasing cell proliferation and inducing apoptosis. EEDM-induced apoptosis in U937 cells was associated with the upregulation of death receptor-related protein levels and downregulation of anti-apoptotic IAP family proteins. The increase in apoptosis was also associated with proteolytic activation of caspase-8, -9 and -3, inhibition of anti‑apoptotic Bcl-2 and Bcl-xL expression, Bid cleavage, and loss of MMP suggesting that apoptosis of U937 cells induced by EEDM was through the extrinsic and intrinsic pathways. However, a pan-caspase inhibitor, z-VED-fmk, significantly inhibited EEDM-induced U937 cell apoptosis indicating that the caspases were key regulators of apoptosis in response to EEDM in U937 cells. Our data suggest that D. morbifera may be a potential anticancer agent for cancer treatment.

  5. Focal adenomyosis (intramural endometriotic cyst) in a very young patient - differential diagnosis with uterine fibromatosis

    Science.gov (United States)

    Manta, L; Suciu, N; Constantin, A; Toader, O; Popa, F

    2016-01-01

    Introduction. Adenomyosis is a widespread disease usually affecting the late reproductive years of the women’s life, which has a great impact on their fertility. The most common form is diffuse adenomyosis, while focal adenomyosis, a cystic variant, is very rare, particularly in patients younger than 30 years old. Materials and methods. We reported a rare case of a 20-year-old Caucasian woman with cystic adenomyosis who was admitted in our service with severe chronic pelvic pain, dysmenorrhea, and menorrhagia, who had received conservative surgical treatment to preserve fertility and improve her obstetrical prognosis. Results and Discussions. Although the necrobiosis of a uterine fibroid was suspected preoperatively, the extemporaneous histopathological exam revealed adenomyosis associated with fibroleiomyoma with hyaline dystrophy and multiple foci of endometriosis of cystic formation in the wall of a young woman without any risk factors. Conclusion. Although a rare lesion in young patients, cystic adenomyosis should be considered when chronic pelvic pain is exacerbated during menstruation and is associated with a uterine tumor. In young patients, the differential diagnosis should be made with uterine malformations (hematometra), necrobiosis of uterine fibroids, pelvic endometriosis. The surgical treatment should be conservative with the excision of the lesion, always taking into account fertility preservation in young patients. PMID:27453751

  6. Effectiveness of the cyclic administration of dienogest in a case of pathological disappearance of intestinal endometriosis

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    Tamura R

    2013-07-01

    Full Text Available Ryo Tamura, Ikunosuke Tsuneki, Toru Yanase Department of Obstetrics and Gynecology, Niigata City General Hospital, Niigata, Japan Abstract: We have reported good control of atypical genital bleeding when using a cyclic administration of dienogest (repeated 4-week cycles, each consisting of the administration of 2 mg/day of dienogest for 3 weeks, followed by 1 week of drug withdrawal in patients with endometriosis. Herein, we report the effectiveness of the long-term cyclic administration (22 months of dienogest in a case of pathological disappearance of intestinal endometriosis diagnosed by endoscopy and histology of the lower gastrointestinal tract. There is no recurrent sign after 16 months of the treatment being stopped. Atypical genital bleeding during treatment was 3–5 days a month in each cycle. Compliance was good, so we could continue the therapy. The long-term cyclic administration of dienogest in patients with intestinal endometriosis may have significant merit. Keyword: atypical genital bleeding, dysmenorrhea, drug compliance, endoscopy, histology

  7. Osteopathic manipulative treatment in gynecology and obstetrics: A systematic review.

    Science.gov (United States)

    Ruffini, Nuria; D'Alessandro, Giandomenico; Cardinali, Lucia; Frondaroli, Franco; Cerritelli, Francesco

    2016-06-01

    The aim of the review was to evaluate the effects of the osteopathic manipulative treatment (OMT) on women with gynaecological and obstetric disorders. An extensive search from inception to April 2014 was conducted on MEDLINE, Embase, the Cochrane library using MeSH and free terms. Clinical studies investigating the effect of OMT in gynaecologic and obstetric conditions were included as well as unpublished works. Reviews and personal contributions were excluded. Studies were screened for population, outcome, results and adverse effects by two independent reviewers using an ad-hoc data extraction form. The high heterogeneity of the studies led to a narrative review. 24 studies were included (total sample=1840), addressing back pain and low back functioning in pregnancy, pain and drug use during labor and delivery, infertility and subfertility, dysmenorrhea, symptoms of (peri)menopause and pelvic pain. Overall, OMT can be considered effective on pregnancy related back pain but uncertain in all other gynaecological and obstetrical conditions. Only three studies (12.5%) mentioned adverse events after OMT. Although positive effects were found, the heterogeneity of study designs, the low number of studies and the high risk of bias of included trials prevented any indication on the effect of osteopathic care. Further investigation with more pragmatic methodology, better and detailed description of interventions and systematic reporting of adverse events are recommended in order to obtain solid and generalizable results. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Characterization of the Active Constituents in Shixiao San Using Bioactivity Evaluation Followed by UPLC-QTOF and Markerlynx Analysis

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    Er-Xin Shang

    2010-09-01

    Full Text Available Shixiao San is a famous Traditional Chinese Medicine (TCM formula that has been used for a long time for the treatment of gynecological diseases. In this paper, the active constituents in Shixiao San were characterized by using bioactivity evaluation followed by UPLC-QTOF and MarkerlynxTM analysis. The analgesic activities of two extracts of Shixiao San were evaluated using the hot-plate test, acetic acid-induced writhing and dysmenorrhea mice model. The results showed that the analgesic activity of Shixiao San vinegary extract (boiling vinegar was superior to the aqueous extract. UPLC-QTOF and MarkerlynxTM analytic results showed that the process of boiling in vinegar may improve the dissolution of Shixiao San flavanoids, and these flavanoids may contribute to the observed analgesic activity. This work demonstrated that UPLC/QTOFMS and MarkerlynxTM could serve as new methods for fast generation and automated analysis of information-rich data from Chinese herbal medicines.

  9. PSEUDO CENTRAL CERVICAL FIBROID IN A NULLIPAROUS GIRL: A CASE REPORT

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    Priyankur

    2014-08-01

    Full Text Available Fibroids are benign (non-cancerous growths on the uterus. There is an overall incidence of 20% in women more than 30yrs of age. The incidence of cervical fibroids is much lower at 1-2%. An unmarried girl presented with complaints of difficulty in passing urine, lower abdominal pain and spasmodic dysmenorrhea for 4 months. Per abdomen there was a firm, non-tender midline mass arising from the pelvis corresponding to 20 weeks size gravid uterus with restricted mobility. Cervix could not be felt. Ultrasonographic examination showed 10.2x10.7 cm fibroid in the posterior wall with no adnexal pathology and bilateral mild hydronephrosis. On laparotomy, the uterus was found to be sitting like a lantern on the dome of St. Paul's Cathedral. A 25x18 cm pseudo central cervical fibroid, partly intramural, partly sub mucous was seen to arise from the posterior cervico isthmic region. Myomectomy was performed successfully. Central cervical fibroid expands the cervix equally in all directions and the uterus is elevated on top of the large tumor. Diagnosis is by ultrasonogram and HSG. Management in cervical fibroid of supravaginal portion is hysterectomy if fertility is not desired and myomectomy if the patient is young and fertility is desired, as in our case.

  10. Review of Pharmacological Properties and Chemical Constituents of Pimpinella anisum.

    Science.gov (United States)

    Shojaii, Asie; Abdollahi Fard, Mehri

    2012-01-01

    Pimpinella anisum (anise), belonging to Umbelliferae family, is an aromatic plant which has been used In Iranian traditional medicine (especially its fruits) as carminative, aromatic, disinfectant, and galactagogue. Because the wide traditional usage of Pimpinella anisum for treatment of diseases, in this review published scientific reports about the composition and pharmacological properties of this plant were collected with electronic literature search of GoogleScholar, PubMed, Sciencedirect, Scopus, and SID from 1970 to 2011. So far, different studies were performed on aniseeds and various properties such as antimicrobial, antifungal, antiviral, antioxidant, muscle relaxant, analgesic and anticonvulsant activity as well as different effects on gastrointestinal system have been reported of aniseeds. It can also reduce morphine dependence and has beneficial effects on dysmenorrhea and menopausal hot flashes in women. In diabetic patients, aniseeds showed hypoglycemic and hypolipidemic effect and reduce lipid peroxidation. The most important compounds of aniseeds essential oil were trans-anetole, estragole, γ-hymachalen, para-anisaldehyde and methyl cavicol. Due to broad spectrum of pharmacological effects, and very few clinical studies of Pimpinella anisum, more clinical trials are recommended to evaluate the beneficial effects of this plant in human models and synthesis of new drugs from the active ingredients of this plant in future.

  11. Morinda citrifolia (Noni as an Anti-Inflammatory Treatment in Women with Primary Dysmenorrhoea: A Randomised Double-Blind Placebo-Controlled Trial

    Directory of Open Access Journals (Sweden)

    H. M. Fletcher

    2013-01-01

    Full Text Available Introduction. Noni (Morinda citrifolia has been used for many years as an anti-inflammatory agent. We tested the efficacy of Noni in women with dysmenorrhea. Method. We did a prospective randomized double-blind placebo-controlled trial in 100 university students of 18 years and older over three menstrual cycles. Patients were invited to participate and randomly assigned to receive 400 mg Noni capsules or placebo. They were assessed for baseline demographic variables such as age, parity, and BMI. They were also assessed before and after treatment, for pain, menstrual blood loss, and laboratory variables: ESR, hemoglobin, and packed cell volume. Results. Of the 1027 women screened, 100 eligible women were randomized. Of the women completing the study, 42 women were randomized to Noni and 38 to placebo. There were no significant differences in any of the variables at randomization. There were also no significant differences in mean bleeding score or pain score at randomization. Both bleeding and pain scores gradually improved in both groups as the women were observed over three menstrual cycles; however, the improvement was not significantly different in the Noni group when compared to the controls. Conclusion. Noni did not show a reduction in menstrual pain or bleeding when compared to placebo.

  12. Bladder Endometriosis Mimicking TCC - A Case Report.

    Science.gov (United States)

    Gupta, Asish; Bhatnagar, Atul; Seth, B N; Dang, Arbinder; Gupta, Vineeta

    2016-02-01

    Endometriosis is the ectopic presence of endometrial tissue outside the uterus. Though on its own endometriosis is not a rare lesion, the involvement of the urinary tract is rare but with the bladder being the most commonly affected organ. Endometriosis is usually seen in females between the ages of 30-40 years and may occur due to fluctuating levels of oestrogen and progesterone. Clinically the patient maybe asymptomatic or show symptoms of dysmenorrhea, irregular or heavy periods, pain in the pelvic area, lower abdomen or in the back. It has been suggested that ultrasonography should be done either before or during menstruation as the lesion becomes more evident and a biopsy taken during this period is a strong aid in reaching a final diagnosis. We report here an unusual case of bladder endometriosis where the patient came with severe pelvic pain and an endoluminal mass seen on the ultrasonographic report. Based on these findings a differential of transitional cell carcinoma was given which was ruled out based on the cystoscopic findings.

  13. Pathophysiology and Immune Dysfunction in Endometriosis

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    Soo Hyun Ahn

    2015-01-01

    Full Text Available Endometriosis is an estrogen-dependent, chronic, proinflammatory disease prevalent in 10% of women of reproductive age worldwide. Characterized by the growth of endometrium-like tissue in aberrant locations outside of the uterus, it is responsible for symptoms including chronic pelvic pain, dysmenorrhea, and subfertility that degrade quality of life of women significantly. In Canada, direct and indirect economic cost of endometriosis amounts to 1.8 billion dollars, and this is elevated to 20 billion dollars in the United States. Despite decades of research, the etiology and pathophysiology of endometriosis still remain to be elucidated. This review aims to bring together the current understanding regarding the pathogenesis of endometriosis with specific focus on mechanisms behind vascularization of the lesions and the contribution of immune factors in facilitating lesion establishment and development. The role of hormones, immune cells, and cytokine signaling is highlighted, in addition to discussing the current pharmaceutical options available for management of pain symptoms in women with endometriosis.

  14. Uterine arterial embolization for uterine leiomyoma: efficacy and clinical outcome

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    Park, Jeong Seon; Lee, Do Yon; Kim, Yong Tae; Park, Ki Hyun; Park, Yong Won; Cho, Jae Sung; Kim, Myung Jun [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of); Won, Je Hwan [Ajou Univ. College of Medicine, Suwon (Korea, Republic of); Kang, Byung Chul [Ewha Womans Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-09-01

    To determine the efficacy and clinical outcome of uterine arterial embolization as a new approach to the management of uterine leiomyomas. Uterine arterial embolization was performed in 21 patients aged 26-62(mean, 42) years. Twenty of these had menorrhagia, dysmenorrhea, and mass-related symptoms (low abdominal discomfort, backache, urinary frequency, etc.) and one was diagnosed incidentally. Bilateral uterine arteries were selected individually and polyvinyl alcohol and/or gelfoam was used as an embolic material. Nineteen patients were followed up after embolization. Seventeen (89.5 %)reported satisfactory improvement of symptoms and follow-up sonography three months later showed a 58.5 % reduction in mean myoma volume. In 17 patients (89.5 %), the menstrual cycle returned to normal. All patients experienced pain after the procedure and other complications were vaginal bleeding (26.3 %) and fever (23.8 %). Uterine arterial embolization represents a new approach to the management of uterine leiomyoma-related symptoms. Further investigations and long-term follow-up are, however, enquired.

  15. Menstrual Cycle Changes in Women with Inflammatory Bowel Disease: A Study from the Ocean State Crohn's and Colitis Area Registry

    Science.gov (United States)

    Saha, Sumona; Zhao, Yingqi; Shah, Samir A.; Esposti, Silvia Degli; Lidofsky, Sheldon; Salih, Sana; Bright, Renee; Law, Meaghan; Moniz, Heather; Flowers, Nicole; Merrick, Marjorie; Sands, Bruce E.

    2014-01-01

    Background and Aims The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year prior to IBD diagnosis or in the initial years after diagnosis. Methods Women aged 18 and above in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. All subjects were enrolled within 6 months of IBD diagnosis and followed prospectively. Menstrual cycle characteristics were retrospectively assessed. To assess for changes over time, general linear models for correlated data were used for continuous outcomes and generalized estimating equations were used for discrete outcomes. Results 121 subjects were studied. Twenty-five percent of subjects experienced a change in cycle interval in the year prior to IBD diagnosis and 21% experienced a change in duration of flow. Among women with dysmenorrhea, 40% experienced a change in the intensity of their menstrual pain and 31% experienced a change in its duration. Overall cycle regularity increased over time.. Quality of life (QOL) was significantly lower in women without regular cycles across all time points. Conclusions Changes in menstrual function occur frequently in the year prior to IBD diagnosis; therefore screening for menstrual irregularities should be considered in women with newly diagnosed IBD. Patients can be reassured that cycles typically become more regular over time. PMID:24451220

  16. COMPARATIVE ANALYSIS OF DIFFERENT BRANDS OF DICLOFENAC SODIUM

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    SAFILA NAVEED

    2014-08-01

    Full Text Available Objective: The aim of this study to analyze the different brands of diclofenac sodium. Diclofenac is a widely used analgesic, classified as Non steroidal anti inflammatory drug. In different clinical conditions such as acute or chronic pain and inflammation especially as in surgery, back pain, dysmenorrhea, renal and biliary colic as well as in postoperative and post-traumatic conditions, diclofenac sodium has been an effective analgesic agent. No one of the NSAID non-steroidal anti-inflammatory agents is suitable drug for all patients requiring such therapy. Therefore it is important to choose best brand because different brands available in markeet. Method: In our present study different brands of Diclofenac Sodium are evaluated for weight variation, hardness and friability. Results: The results showed that all parameters (weight-variation, thickness, hardness, friability of different brands of Diclofenac Sodium, are in accordance with the BP/USP limits. Conclusion: We conclude that all drugs are in accordance with USP/BP therefore we can choose from any one of them for therapeutic purpose.

  17. Coxibs: Evolving role in pain management.

    Science.gov (United States)

    Katz, Nathaniel

    2002-12-01

    Traditional pain management strategies have relied on the use of opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen, as well as other adjuvant analgesics. However, the limited activity of these drugs and the substantial adverse effects associated with their use has left many patients without dependable options for effective treatment. Recent advances in the understanding of pain and its pathophysiologic mechanisms have led to the development of novel therapeutic options. Cyclooxygenase (COX)-2-specific inhibitors (coxibs) have an established efficacy in the treatment of chronic arthritic pain comparable to that of traditional NSAIDs, without the degree of gastrointestinal (GI) complications commonly attributed to NSAID use. Recent trials also have shown the effectiveness of 1 of the coxibs for relief of chronic lower back pain. Numerous studies have shown that coxibs are efficacious for the management of acute pain in various clinical settings, including orthopedic surgery, dental surgery, and dysmenorrhea. The superior safety profile of coxibs in conjunction with a comparable efficacy to nonselective NSAIDs supports the use of coxibs in balanced analgesic regimens. Decreased GI and antiplatelet effects of coxibs compared to traditional NSAIDs provide the potential to incorporate coxibs into the pain management algorithm used to treat cancer pain.

  18. Prevention of unintended pregnancy and use of contraception-important factors for preconception care.

    Science.gov (United States)

    Kallner, Helena Kopp; Danielsson, Kristina Gemzell

    2016-09-20

    Preservation of fertility and optimizing health before pregnancy is becoming increasingly important in societies where childbirth often is postponed. Research shows that as women postpone childbirth they achieve higher levels of education and higher incomes. This leads to advantages for their children and for society. However, as women postpone childbearing they are at risk for contracting conditions which may affect fertility and/or pregnancies, pregnancy outcome, and the newborn child. Preconception counseling is therefore becoming increasingly important. Women are often unaware of the added health benefits of contraception and have the right to be well informed so they can make decisions to fulfill their reproductive desires. Contraception can reduce the risk of unintended pregnancies, ectopic and molar pregnancies, and sexually transmitted infections. In addition, hormonal contraceptives reduce the risk of some types of cancer, dysmenorrhea, heavy menstrual bleeding, and anemia and are a treatment for endometriosis. Contraception should increasingly be looked upon as a means of preserving fertility and optimizing health status before a planned pregnancy. Thus, effective contraception can provide women with a possibility of achieving their long-term reproductive goals, although childbearing is actually postponed. The most effective contraceptive methods are the long-acting reversible contraceptives, which have been shown to be highly effective especially in young women who have difficulties with adherence to user-dependent methods. Therefore, these methods should increasingly be promoted in all age groups.

  19. Inductive effect of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus on in vitro production of estradiol.

    Science.gov (United States)

    Telefo, P B; Moundipa, P F; Tchouanguep, F M

    2004-04-01

    In the course of a preliminary clarification of the mechanisms of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus, locally used to regulate the menstrual cycle and to treat dysmenorrhea or cases of infertility in women, pieces of proestrus rat ovary were incubated in the presence of increasing concentration of the plant extract and/or human Chorionic Gonadotropin (hCG). The in vitro production of estradiol and progesterone by ovarian cells of proestrus rat was significantly increased in the presence of various concentration of hCG (P < 0.05). The different concentration of the plant extract increased the production of estradiol by twofold. In addition, the in vitro production of estradiol by ovarian cells increased by 13-fold when they were incubated with hCG (0.1 IU/ml) and a concentration of 130 microg/ml of the plant extract. These results clearly attest the direct effects of some chemical components of the leaf mixture of the plants on ovarian steroidogenesis.

  20. Morinda citrifolia (Noni) as an Anti-Inflammatory Treatment in Women with Primary Dysmenorrhoea: A Randomised Double-Blind Placebo-Controlled Trial.

    Science.gov (United States)

    Fletcher, H M; Dawkins, J; Rattray, C; Wharfe, G; Reid, M; Gordon-Strachan, G

    2013-01-01

    Introduction. Noni (Morinda citrifolia) has been used for many years as an anti-inflammatory agent. We tested the efficacy of Noni in women with dysmenorrhea. Method. We did a prospective randomized double-blind placebo-controlled trial in 100 university students of 18 years and older over three menstrual cycles. Patients were invited to participate and randomly assigned to receive 400 mg Noni capsules or placebo. They were assessed for baseline demographic variables such as age, parity, and BMI. They were also assessed before and after treatment, for pain, menstrual blood loss, and laboratory variables: ESR, hemoglobin, and packed cell volume. Results. Of the 1027 women screened, 100 eligible women were randomized. Of the women completing the study, 42 women were randomized to Noni and 38 to placebo. There were no significant differences in any of the variables at randomization. There were also no significant differences in mean bleeding score or pain score at randomization. Both bleeding and pain scores gradually improved in both groups as the women were observed over three menstrual cycles; however, the improvement was not significantly different in the Noni group when compared to the controls. Conclusion. Noni did not show a reduction in menstrual pain or bleeding when compared to placebo.

  1. A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice.

    Science.gov (United States)

    Cora, Michelle C; Gwinn, William; Wilson, Ralph; King, Debra; Waidyanatha, Suramya; Kissling, Grace E; Brar, Sukhdev S; Olivera, Dorian; Blystone, Chad; Travlos, Greg

    2017-07-01

    Black cohosh rhizome, available as a dietary supplement, is most commonly marketed as a remedy for dysmenorrhea and menopausal symptoms. A previous subchronic toxicity study of black cohosh dried ethanolic extract (BCE) in female mice revealed a dose-dependent ineffective erythropoiesis with a macrocytosis consistent with the condition known as megaloblastic anemia. The purpose of this study was to investigate potential mechanisms by which BCE induces these particular hematological changes. B6C3F1/N female mice (32/group) were exposed by gavage to vehicle or 1,000 mg/kg BCE for 92 days. Blood samples were analyzed for hematology, renal and hepatic clinical chemistry, serum folate and cobalamin, red blood cell (RBC) folate, and plasma homocysteine and methylmalonic acid (MMA). Folate levels were measured in liver and kidney. Hematological changes included decreased RBC count; increased mean corpuscular volume; and decreased reticulocyte, white blood cell, neutrophil, and lymphocyte counts. Blood smear evaluation revealed increased Howell-Jolly bodies and occasional basophilic stippling in treated animals. Plasma homocysteine and MMA concentrations were increased in treated animals. Under the conditions of our study, BCE administration caused hematological and clinical chemistry changes consistent with a functional cobalamin, and possibly folate, deficiency. Further studies are needed to elucidate the mechanism by which BCE causes increases in homocysteine and MMA.

  2. Aromatase inhibitors in the treatment of deep endometriosis

    Directory of Open Access Journals (Sweden)

    Simone Ferrero

    2009-09-01

    Full Text Available Recent case reports and pilot studies suggested that aromatase inhibitors might be effective in treating pain symptoms related to the presence of endometriosis. We present the case of a 32-year-old woman who suffered dysmenorrhea, dyspareunia, chronic pelvic pain, and dyschezia caused by rectovaginal endometriosis. Pain symptoms recurred after treatment with the oral contraceptive pill; the patient refused surgery. Therefore a double-drug regimen including letrozole (2.5 mg/day and norethisterone acetate (2.5 mg/day was offered to the patient. The scheduled length of treatment was six months. This double-drug regimen determined a quick and significant improvement in all pain symptoms. During treatment, the patient complained mild arthralgia. After the interruption of treatment, pain symptoms quickly recurred and at 6-month follow-up their intensity was similar to baseline values. Operative laparoscopy was performed, the presence of rectovaginal endometriosis was confirmed and all visible endometriotic lesions were excised. Aromatase inhibitors might be offered when pain symptoms caused by endometriosis persist during the administration of other hormonal therapies and the patient refuses surgery. However, women must be informed that these drugs determine only a temporary relief of pain symptoms and might cause adverse effects (such as arthralgia.

  3. Müllerian duct anomalies and mimics in children and adolescents: correlative intraoperative assessment with clinical imaging.

    Science.gov (United States)

    Junqueira, Beatriz L P; Allen, Lisa M; Spitzer, Rachel F; Lucco, Kerith L; Babyn, Paul S; Doria, Andrea S

    2009-01-01

    Müllerian duct anomalies (MDAs) are congenital entities that result from nondevelopment, defective vertical or lateral fusion, or resorption failure of the müllerian (paramesonephric) ducts. MDAs are common, although the majority are asymptomatic, and have been classified by the American Society of Reproductive Medicine according to clinical manifestations, prognosis, and treatment. Accurate diagnosis of an MDA is essential, since the management approach varies depending on the type of malformation. In females, when a müllerian duct becomes obstructed, the patient may present with an abdominal mass and dysmenorrhea. If the patient is not treated in a timely fashion, the consequences can be severe, extending even to infertility. When an MDA is suspected, ultrasonography (US) should be performed initially to delineate any abnormalities in the genital tract. However, US cannot help identify the type of MDA. In contrast, magnetic resonance imaging is a valuable technique for noninvasive evaluation of the female pelvic anatomy and accurate MDA classification. If obstruction is present, surgical correction of the MDA may be required, and further counseling of the patient with regard to reproductive possibilities becomes important. Supplemental material available at http://radiographics.rsnajnls.org/cgi/content/full/29/4/1085/DC1.

  4. 蝎毒疗法临床治疗乳腺癌股骨头坏死的体会

    Institute of Scientific and Technical Information of China (English)

    张铭信

    2015-01-01

    The scorpion has ever been the medical profession recognized is a rare medicinal herbs in China, "Bencao Gangmu" records of the scorpion has a wind out spasm, effect of Sanjie, active attack, relieve swelling and pain and dysmenorrhea.Effect of scorpion scorpion venom is 18 times, including anticancer, antiviral, anti-inflammatory, analgesic and so on many kinds of protein peptide, combined with traditional Chinese medicine prescription and treatment based on syndrome differentiation, treatment of breast cancer and avascular necrosis of the femoral headhave a magical effect, and no toxic side effect, low cost, and is worthy of clinicalpromotion of large capacity.%全蝎自古以来就被医疗界认定是我国的名贵药材,《本草纲目》记载了全蝎具有熄风解痉、攻毒散结、痛经活络、消肿止痛等功效。蝎毒功效是全蝎的18倍,内含抗癌、抗炎、抗病毒、镇痛等多种蛋白质短肽,结合中医经方和辩证施治,临床治疗乳腺癌和股骨头坏死有着神奇的效果,且无任何毒副作用,费用低,值得临床大力推广。

  5. Spasmolytic effect of constituents from Lepechinia caulescens on rat uterus.

    Science.gov (United States)

    Perez-Hernandez, Nury; Ponce-Monter, Hector; Medina, Jorge A; Joseph-Nathan, Pedro

    2008-01-04

    Lepechinia caulescens Ortega Epling (Lamiaceae) is a perennial herb used in Mexican folk medicine to treat diabetes, hypertension, gastrointestinal infections, dysmenorrhea and as abortifacient. In this study, a bioassay-guided fractionation of the hexanes extract of the leaves, evaluating the capacity to relax contraction of rat uterus rings induced by KCl (60mM), was made. The results indicated that, from the four isolated terpenes, spathulenol (1) was the most potent spasmolytic agent, followed by methyl 9alpha,13alpha-epidioxyabiet-8(14)-en-18-oate (2), 9alpha-hydroxydehydroabietyl alcohol (4) and dehydroabietic acid (3) studied at 10 and 30 microg/mL. The spasmolytic activity of 1 was totally reverted by addition of increasing extracellular Ca2+ concentrations ([Ca2+]o), while incubation of uterus rings with 1 in calcium free solutions reduced the contraction produced by [Ca2+]o in a concentration-dependent manner. Moreover, the presence of L-NAME (100 microM) or propranolol (10 microM) did not block the spasmolytic effect. These results suggest that 1 induces a greater blocking action on voltage-operated calcium channels. EtOAc and MeOH extracts of the leaves, which showed slight relaxing activity, led to 4 and rosmarinic acid (5).

  6. Inhibition of lipopolysaccharid-induced sickness behavior by a dry extract from the roots of Pelargonium sidoides (EPs 7630) in mice.

    Science.gov (United States)

    Nöldner, M; Schötz, K

    2007-01-01

    The host response to infections comprise the synthesis and release of proinflammatory cytokines (e.g. IL-1ss, TNF-alpha, IL-6) which induce symptoms of sickness behavior characterised by anorexia, depressed activity, listlessness or malaise. In laboratory animals, sickness behavior can be induced by the administration of cytokines itself or by cytokine-inducers such as lipopolysaccharide (LPS), the active fragment of endotoxin from Gram-negative bacteria. Preparations from roots of Pelargonium sidoides have been traditionally used in South African folk medicine for the treatment of different diseases (e.g. diarrhea, dysmenorrhea, hepatic disorders and respiratory tract infections including tuberculosis). Today, aqueous ethanolic extracts of Pelargonium sidoides are marketed mainly for respiratory tract infections. We studied the effects of the extract EPs 7630 and different fractions separated by ultrafiltration in an animal model of sickness behavior. The results of this study demonstrate that the extract EPs 7630 and the high-molecular weight fraction (F3) alleviate the symptoms of sickness behavior.

  7. Premenstrual Syndrome in Turkish college students and its effects on life quality.

    Science.gov (United States)

    Pinar, Gul; Colak, Meric; Oksuz, Ergun

    2011-01-01

    The purpose of this research is to analyze the frequency of Premenstrual Syndrome (PMS) in college students, the factors affecting Premenstrual Syndrome and the effect of Premenstrual Syndrome on life quality. The research was performed on 316 students who study at Medical Sciences Faculty of Başkent University and accepted to take part in the research. The data of the research was compiled by using "Questionnaire Form", "PMS Rating Scale" and "Life Quality Scale" developed by the researchers. In the analysis of the data; Percentage distribution, Chi-square test, One Way Anova test, Logistic regression, Multi nominal regression analysis were used. PMS was detected in 72.1% of the students. The most frequent symptoms are mainly low back pain, stress-discomfort, nervous-anger, distention and breast tenderness. PMS was found significantly high in those students who have menstrual irregularity, who have dysmenorrhea, who consume 2 cups of coffee or above per day and who smoke and drink alcohol (pstudents and this adversely affects the life quality. It was revealed that the preventive, instructive and consultancy roles of the medical staff became more of an issue in reducing the effect of the factors causing and/or aggravating these symptoms in order to decrease PMS incidence and to improve the life quality of the students. Copyright © 2010. Published by Elsevier B.V.

  8. Efficacy, safety, and patient acceptability of the etonogestrel and ethinyl estradiol vaginal ring

    Directory of Open Access Journals (Sweden)

    Lete I

    2014-07-01

    Full Text Available Iñaki Lete, Maialen Pérez de Arrilucea, María Rodríguez, Eskerne BelloDepartment of Gynecology, University Hospital Araba, Vitoria, Spain Abstract: The contraceptive vaginal ring (CVR is a combined hormonal contraceptive method, containing ethinyl estradiol and etonogestrel, that works by inhibiting ovulation. It differs from combined oral contraceptives (COCs in the route of administration, which is vaginal, and the frequency of administration, which is monthly. The efficacy of the CVR is similar to that of COCs but compliance appears to be better in typical users. The CVR enables appropriate control of the menstrual cycle, with a similar side effect profile to COCs, while achieving good user acceptance. Different studies have established noncontraceptive beneficial effects of the CVR; for example, it can be useful for treating dysmenorrhea or excess menstrual bleeding. Recent epidemiological studies have confirmed that the risk of venous thromboembolism with the CVR is similar to that of COCs, including COCs that contain levonorgestrel. Keywords: contraceptive vaginal ring, efficacy, cycle control, acceptability, safety

  9. [Intra-uterine device and nulliparous women].

    Science.gov (United States)

    Trignol-Viguier, N; Blin, E; Marret, H

    2014-06-01

    Intra-uterine device (IUD) is one of the birth control methods, which is available for nulliparous women, even though misconceptions still remain in medical or popular opinion. Only 1.3 % of nulliparous have a IUD as contraception in France while it is the second methods used by all women, after pill. The best contraception is the one chosen by women; however, the choice for a nulliparous of an IUD may be really difficult, despite the increasing number of women wishing to use it. Long-acting reversible contraceptives utilization, including IUD, is probably one of the issues to decrease the unintended pregnancies. An exhaustive and clear information about IUD is necessary to allow an informed and real choice. This prescription must consider contraindications and medical conditions for safe insertion, especially to avoid infection by screening STD (Chlamydia trachomatis and Nesseria gonorrhoeae) in nulliparous womenIUD preferred. Even if side effects such as expulsion, pelvic pains or dysmenorrhea are more frequent by nulliparous, IUD is a first intention choice for contraception to be consider, that women could obtain easily, including in emergency contraception situation.

  10. Meta-analysis of bipolar radiofrequency endometrial ablation versus thermal balloon endometrial ablation for the treatment of heavy menstrual bleeding.

    Science.gov (United States)

    Zhai, Yan; Zhang, Zihan; Wang, Wei; Zheng, Tingping; Zhang, Huili

    2017-10-06

    Heavy menstrual bleeding is a common problem that can severely affect quality of life. To compare bipolar radiofrequency endometrial ablation and thermal balloon ablation for heavy menstrual bleeding in terms of efficacy and health-related quality of life (HRQoL). Online registries were systematically searched using relevant terms without language restriction from inception to November 24, 2016. Randomized control trials or cohort studies of women with heavy menstrual bleeding comparing the efficacy of two treatments were eligible. Data were extracted. Results were expressed as risk ratios (RRs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs). Six studies involving 901 patients were included. Amenorrhea rate at 12 months was significantly higher after bipolar radiofrequency endometrial ablation than after thermal balloon ablation (RR 2.73, 95% CI 2.00-3.73). However, no difference at 12 months was noted for dysmenorrhea (RR 1.04, 95% CI 0.68-1.58) or treatment failure (RR 0.78, 95% CI 0.38-1.60). The only significant difference for HRQoL outcomes was for change in SAQ pleasure score (12 months: WMD -3.51, 95% CI -5.42 to -1.60). Bipolar radiofrequency endometrial ablation and thermal balloon ablation reduce menstrual loss and improve quality of life. However, bipolar radiofrequency endometrial ablation is more effective in terms of amenorrhea rate and SAQ pleasure. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  11. GOSSYPIUM HERBACEUM LINN: AN ETHNOPHARMACOLOGICAL REVIEW

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    Rahman Khaleequr

    2012-10-01

    Full Text Available Gossypium herbaceum Linn is known as cotton plant, belongs to the family Malvaceae, and occupies an imperative place in traditional systems of medicine especially in Unani and Ayurvedic medicines. The plant is widely distributed throughout western India, Africa, Middle East countries, central Asia and graded availability is found in Iran, Afghanistan, Russian and Turkistan. The qualitative phytochemical study of this plant extract indicates the presence of carbohydrates, saponins, steroids, glycosides, phenolic compounds such as tannins and flavonoids. The principle pigment of cotton seed is gossypol, a phenolic compound. The unsaponifiable fraction of Indian cottonseed oil contains sitosterol, ergostoerol, lipids, gossypol, oleic, palmitic, and linoleic acids. The herb has been used traditionally from antiquity, in the treatment of inadequate lactation, bronchial asthma, dysmenorrhea, diarrhea, dysentery, otalgia, sexual debility, general weakness, diabetes, lung and skin diseases. It chiefly possesses antifertlility, galactagogue, antispermatogenic, antidiabetic, antiviral and antibacterial activity. This work is an endeavor to explore and assemble the various pharmacological action and pharmacognostic aspects of the plant G. herbaceum reported till date.

  12. Analysis of the Effect of Levonorgestrel Releasing Intrauterine System in the Treatment of Uterine Gland Myopathy%左炔诺孕酮宫内缓释系统治疗子宫腺肌症效果分析

    Institute of Scientific and Technical Information of China (English)

    陶俐辛

    2015-01-01

    目的:探究子宫腺肌症采用左炔诺孕酮宫内缓释系统治疗的临床疗效。方法选取42例子宫腺肌症患者,均采用左炔诺孕酮宫内缓释系统治疗,分析临床疗效。结果治疗后患者痛经评分、月经量、子宫体积、Hb(血红蛋白浓度)以及CA125(糖类抗原125)等均优于治疗前(P <0.05)。结论子宫腺肌症采用左炔诺孕酮宫内缓释系统治疗效果显著。%Objective The clinical curative effect of adenomyosis treated with levonorgestrel releasing intrauterine system.Methods Select 42 cases of patients with uterine gland muscle disease,al the levonorgestrel releasing intrauterine system in the treatment,to observe and compare the clinical indexes of patients before and after treatment.ResultsAfter treatment, dysmenorrhea score, menstrual volume, uterine volume, Hb (hemoglobin concentration) and CA125 (carbohydrate antigen 125) were superior to those of the treatment (P < 0.05). ConclusionAdenomyosis of levonorgestrel releasing intrauterine system in the treatment effect is significant.

  13. Contraceptive implants: current perspectives

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    Rowlands S

    2014-09-01

    Full Text Available Sam Rowlands,1,2 Stephen Searle3 1Centre of Postgraduate Medical Research and Education, School of Health and Social Care, Bournemouth University, Bournemouth, United Kingdom; 2Dorset HealthCare, Bournemouth, United Kingdom; 3Sexual Health Services, Chesterfield, United KingdomAbstract: Progestin-only contraceptive implants are a highly cost-effective form of long-acting reversible contraception. They are the most effective reversible contraceptives and are of a similar effectiveness to sterilization. Pregnancies are rare in women using this method of contraception, and those that do occur must be fully investigated, with an ultrasound scan of the arm and serum etonogestrel level if the implant cannot be located. There are very few contraindications to use of implants, and they have an excellent safety profile. Both acceptability and continuation with the method are high. Noncontraceptive benefits include improvements in dysmenorrhea, ovulatory pain, and endometriosis. Problematic bleeding is a relatively common adverse effect that must be covered in preinsertion information-giving and supported adequately if it occurs. Recognized training for both insertion and removal should be undertaken. Care needs to be taken at both insertion and removal to avoid neurovascular injury. Implants should always be palpable; if they are not, noninsertion should be assumed until disproven. Etonogestrel implants are now radiopaque, which aids localization. Anticipated difficult removals should be performed by specially trained experts. Keywords: contraceptive, subdermal implant, etonogestrel, levonorgestrel, progestin-only, long-acting reversible contraception

  14. [Abdomino-pelvic actinomycosis associated with an intrauterine device. Apropos of a case].

    Science.gov (United States)

    Domecq, G; Mendoza, E; Docobo, F; Lozano, M; Gavilan, F; Fernández Dovale, M

    1982-05-01

    Although over 300 cases of pelvic actinomycosis have been published, it was not until 1973 that the 1st case of pelvic actinomycosis associated with the new generation of IUDs was described. Data is provided in this article on the causative agent, laboratory procedures, surgical excision, and pathological studies in 1 case of abdominal-pelvic actinomycosis, and the findings are compared to other reports in the English and Spanish literature. A multipara of 25 years with fever, metrorrhagia, and painful tumoration began to suffer dysmenorrhea in June 1980 but attributed the symptoms to the Copper 250 Multiload IUD she had used since July 1979. A laparotomy in December 1980 disclosed the infection, and pathological tests confirmed the diagnosis. The exact incidence of the association of actinomycosis and the IUD is not known, but the microorganism, Actinomyces-Israeli, is more common in wearers of IUDs than in other women. The diagnosis of actinomycosis is confirmed through microbiological study and histological identification. Treatment since 1945 has consisted of large doses of penicillin over long periods of time, but the use of other antibiotics including tetracycline and erythromycin has been introduced. The abscess or abscesses should be excised and the IUD removed in cases where a relationship is suspected.

  15. [Adnexal actinomycosis in a woman using an intrauterine contraceptive device (IUD)].

    Science.gov (United States)

    Pawlina, W; Bogdanowicz, M

    1987-01-01

    The case-study of genital actinomycosis in a 33-year old woman wearing a "Copper T200" IUD is presented. She was hospitalized and treated for lower abdominal pain and non-characteristic signs of adnexitis twice. Adnexectomy on the left side was performed to remove an orange-size cyst. Histo-pathological examination of a prepared tissue sample revealed a colony of Actinomyces. Following the operation the patient was treated with 3 x 500 mg Flagyl (metronidazole) 3 x 80 mg of Gentamicin im. The wound healed in 19 days after operation. This woman had worn the IUD continuously for more than 3 years, thus there was an increased risk of uterine lesions. The most frequent consequences of wearing IUDs for a long time are dysmenorrhea and endometritis and therapeutic approaches are detailed. Since its first description in the literature in 1857 actinomycosis has not been mentioned frequently. However, with the spread of IUDs, the number of actinomycosis-like cases has increased and this justifies the need for improved diagnosis. The frequency of actinomycosis occurring in women wearing IUDs ranges between 1.6% and 19.7%

  16. Heterotopic respiratory mucosa of the uterine corpus

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    Sarala Ravindran

    2016-03-01

    Full Text Available A 47-year-old, single, Chinese woman presented with pain on the 1st day of menses for more than 30 years. Her dysmenorrhea worsened over years and underwent a total abdominal hysterectomy and bilateral salpingooophorectomy. The myometrium showed trabeculated appearance, and there were adhesions between ovaries and fallopian tubes. A pale solid brownish mass measuring 1.5 cm and times; 1 cm and times; 0.6 cm with fibrous whitish cut surfaces was present on the lateral wall of the uterus in the lower uterine segment. Histologically, adenomyosis and left ovarian endometriosis were confirmed. The lateral uterine wall nodule showed a tubular structure lined by ciliated pseudostratified columnar epithelium. Smooth muscle bundles were found around the entire tubular structure. Lobules of salivary type glands containing both serous and mucous cells are present. The pathological diagnosis of heterotopic respiratory mucosa (HRM was made. To our knowledge, this is the first reported case of HRM of the uterine corpus. [J Interdiscipl Histopathol 2016; 4(1.000: 26-28

  17. Gynecologic and obstetric implications of the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome hypermobility type) in 82 Italian patients.

    Science.gov (United States)

    Castori, Marco; Morlino, Silvia; Dordoni, Chiara; Celletti, Claudia; Camerota, Filippo; Ritelli, Marco; Morrone, Aldo; Venturini, Marina; Grammatico, Paola; Colombi, Marina

    2012-09-01

    Joint hypermobility syndrome (JHS) emerges as likely the most common clinical form of Ehlers-Danlos syndrome. Given the striking predominance of affected women, practitioners often face gynecologic and obstetric issues. However, their decisions are still based on personal experience rather than literature due to the lack of a consistent body of evidence. We collected a set of gynecologic and obstetric features in 82 post-puberal women with JHS attending two Italian centers. Common gynecologic findings were dysmenorrhea (82.9%), meno/metrorrhagias (53.7%), irregular menses (46.3%), and dispareunia/vulvodinia (31.7%). Forty women were nulliparous and 42 had one or more pregnancy for a total of 93 diagnosed conceptions. Of them, 16.1% were spontaneous abortions, 6.5% voluntary interruptions, 10.7% preterm deliveries, and 66.7% deliveries at term. Overall outcome of proceeding pregnancies was good with no stillbirth and fetal/neonatal hypoxic/ischemic event. Non-operative vaginal delivery was registered in 72.2%, forceps/vacuum use in 5.5% and cesarean in 22.3%. Local/total anesthesia was successfully performed in 17 pregnancies without any problem. Major post-partum complications included abnormal scar formation after cesarean or episiotomy (46.1%), hemorrhage (19.4%), pelvic prolapses (15.3%), deep venous thrombosis (4.2%), and coccyx dislocation (1.4%). Prolapses were the most clinically relevant complication and associated with episiotomy. Gathered data were discussed for practically oriented considerations.

  18. An appropriate solvent for the preparation of Prasaplai extract

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    Prasan Tangyuenyongwatana

    2009-11-01

    Full Text Available Prasaplai is a Thai traditional formulation for relieving dysmenorrhea and adjusting the cycle of menstruation. Threefatty acid esters, (E-4-(3,4-dimethoxyphenylbut-3-en-1-yl linoleate (1, (E-4-(3,4-dimethoxyphenylbut-3-en-1-yl oleate(2 and (E-4-(3,4-dimethoxyphenylbut-3-en-1-yl palmitate (3, were formed during storage by the interaction of componentsin the preparation. The recommended dose (1.0 g of Prasaplai was separately extracted by exhaustive sonication with three different solvents; which are hexane, 40% ethanol and distilled water, and yielded 26.70±0.11 mg (2.7% w/w, 33.96± 0.05 mg (3.40% w/w, and 49.83±0.30 mg (4.98% w/w, respectively. The crude extracts were analyzed by HPLC for contents of the four major compounds i.e (E-1-(3,4-dimethoxyphenylbut-3-en-1-ol (compound D, (E-1-(3,4-dimethoxyphenylbutadiene (DMPBD, piperine, -asarone, and three artifacts. The results showed that only the hexane extractcontained the artifacts while the 40% ethanol extract contained the maximum amounts of the major active anti-inflammatorycomponents, and water extract contained only compound D. These results suggest that the 40% ethanol extract should be theappropriate extract for the preparation of Prasaplai in modern dosage forms due to the high content of active anti-inflammatory agents in the extract.

  19. [Lesion of pelvic organs in secondary varicose veins of the small pelvis].

    Science.gov (United States)

    Tsukanov, Yu T; Tsukanov, A Yu; Levdansky, E G

    2015-01-01

    The authors studied peculiarities of pelvic organs lesions in patients presenting with secondary small pelvic varicose veins (SPVV) induced by endured thrombosis of iliac veins. The study included a total of 70 patients after endured thrombosis of iliac veins verified by radiodiagnostic methods. The average duration of thrombosis amounted to 3.8 years. The patients were subdivided into two groups. The Study Group comprised 48 patients presenting with small pelvic varicose veins revealed by duplex scanning; the Control Group was composed of 22 patients with no varicose pelvic veins. It was determined that characteristic features of patients with secondary SPVV having developed after iliac veins thrombosis included chronic pelvic pain, dilatation of cavernous veins of the rectum, inguinal vein varicosity and varicose veins of the groin and anterior abdominal wall. Formation of secondary SPVV after endured iliac vein thrombosis leads to disorders of pelvic organs, similar to those in primary varicosity, but more often being functional. Endured iliac veins thrombosis in formation of secondary SPVV leads to urination impairments with prevalence of moderately pronounced symptomatology. Small pelvic organs dysfunction in women with secondary SPVV due to endured iliac veins thrombosis manifests itself in dyspareunia, leukorrhea, and dysmenorrhea.

  20. Skipping breakfast is associated with reproductive dysfunction in post-adolescent female college students.

    Science.gov (United States)

    Fujiwara, Tomoko; Nakata, Rieko

    2010-12-01

    Although increasing attention has been paid to the adverse effects of skipping breakfast on quality of life, there are very few reports concerning the relationship between skipping breakfast and reproductive function. Therefore, we examined this issue by conducting a questionnaire survey of female college students aged from 18 to 20 years old. The 5 annual surveys of questionnaire demonstrated that the severity of dysmenorrhea was significantly higher in the population that skipped breakfast. The incidence of irregular menses was also higher in the population that skipped breakfast, although there was no difference in the incidence of premenstrual symptoms. The group that skipped breakfast showed a tendency to suffer from constipation. In addition, despite no difference in body mass index, there was a significantly higher incidence of a self-perception of poor general health among the group that skipped breakfast. These findings suggest that skipping breakfast is associated with menstrual disorders, and affects the physical condition of female college students who are undergoing post-adolescent maturation. Since these menstrual disorders may influence the quality of life of young women not only in the present but also in the future, skipping breakfast should be re-evaluated from the perspective of future reproductive function.

  1. 不孕症妇女子宫内膜异位症危险因素对照研究分析%Controlled Study and Analysis of the Risk Factors of Infertile Women with Endometriosis

    Institute of Scientific and Technical Information of China (English)

    方明珠; 丁书贵; 郭华峰

    2014-01-01

    endometriosis, dysmenorrhea extent, menstrual volume, dyspareunia, oral contraceptives, pregnancy history, pelvic pain, and other factors (P<0.05). Multi-factor logistic regression analysis showed that age, duration of infertility, body mass index, dysmenorrhea, pelvic pain, dyspareunia, and the family history of endometrio-sis are the risk factors related to endometriosis. Conclusion Low BMI value,a family history of endometriosis, menstrual history and pelvic pain are high risk factors of the infertile women with endometriosis, whereas multi-pregnancy is a protective factor of en-dometriosis.

  2. 左炔诺孕酮宫内缓释系统治疗子宫腺疾症的疗效分析%Curative effect analysis of levonorgestrel releasing Intrauterine system which is used in adenomyosis

    Institute of Scientific and Technical Information of China (English)

    刘侠

    2014-01-01

    Objective To study curative effect of Levonorgestrel releasing Intrauterine system which is used in the treatment of adenomyosis.Method Follow the 60 cases of adenomyosis treated with levonorgestrel-releasing intrauterine system from October,2011 to October,2012. The follow-up of two years,Before treatment and after treatment 3,6,12,24 months Visual analog scale (VAS),serum carcinoembryonic antigen (CA125) value,changes and treatment of endometrial menstrual quantity,2 years of patient satisfaction.Results The placement of levonorgestrel releasing intrauterine system after the symptoms of dysmenorrhea patients obviously relieved, menstrual quantity obvious reduction, the menstrual period is shortened obviously,ultrasound examination of the endometrial thickness was significantly thinner,Compared with before treatment, the difference had statistical significance;Compared with before treatment, no significant difference of serum CA125 level and the size of the uterus. The main adverse reactions are:vaginal spotting, a little off the ring, amenorrhea,At the end of 2 satisfaction is 94.58%,the continuation rate was 100%.Conclusion Levonorgestrel releasing intrauterine system is an effective method for treatment of uterine adenomyosis,or suitable for dysmenorrhea and menorrhagia patients with adenomyosis.%目的:探讨子宫腺疾症患者宫内放置左炔诺孕酮宫内缓释系统(LNG-IUS)的临床疗效。方法随机选取2011年10月—2012年10月因子宫腺肌症就诊于我院的患者60例,均放置左炔诺孕酮宫内缓释系统。随诊两年,观察治疗前,治疗后3,6,12和24个月时视觉模拟评分(VAS)、血清癌抗原(CA125)值,月经量、子宫内膜变化及治疗2年患者满意度。结果放置左炔诺孕酮宫内缓释系统后患者痛经症状明显缓解,月经量明显减少,经期明显缩短,超声复查子宫内膜厚度明显变薄,与治疗前比较,差异有统计学意义;血清CA125水

  3. 左炔诺孕酮宫内缓释系统对子宫腺肌病患者月经模式的影响%Effects of Levonorgestrel-Releasing Intrauterine System on Menstrual Patterns of Patients with Adenomyosis

    Institute of Scientific and Technical Information of China (English)

    段志珍; 洪莉; 程艳香

    2013-01-01

    Objective To explore the variation of menstrual patterns of patients who suffered from adenomyosis after the treatment with levonorgestrel via intrauterine releasing system.Methods Seventy patients with adenomyosis who were inserted with levonorgestrel-releasing intrauterine system were selected.The variation of menstrual patterns was assessed through menstrual blood loss method and dysmenorrhea scoring at beginning and 1,3, 6, 9 months after insertion.Results Sixty-five patients completed follow-up, which accounted for 92.9%.Menstrual blood volume of baseline and 1 ,3,6,9 months after therapy was (193.03±134.79), (21.08±32.13),(5.56±7.16), (2.13±4.28), (1.51 ±2.89),respectively.Compared to the baseline, the menstrual blood volume and blood clot of the patients were significantly decreased at 1,3,6,9 months after treatment.The dysmenorrhea score of 27 patients at the same time point was 1.85 ±0.82 (prior-insertion),0.48 ±0.51 (one month post-insertion),0.13 ±0.34 (three months post-insertion), 0 (six months post-insertion), respectively, and the dysmenorrheal normally occurred after vaginal ring operation was obviously relieved after insertion.Conclusion Levonorgestrel-releasing intrauterine system displays good therapeutic effect on improving the menstrual patterns of patients with adenomyosis.%目的 探讨左炔诺孕酮宫内缓释系统对子宫腺肌病患者月经模式的影响.方法 选择因子宫腺肌病放置左炔诺孕酮宫内缓释系统的患者70例.采用月经失血法、痛经评分法评价患者放置前,放置后1,3,6,9个月月经模式.结果 65例患者完成随访,随访率为92.9%.月经量评分:放置前(193.03±134.79)分,放置后1个月(21.08±32.13)分,放置后3个月(5.56±7.16)分,放置后6个月(2.13±4.28)分,放置后9个月(1.51±2.89)分,与放置前比较,放置后1,3,6,9个月患者,月经量、血块均明显减少;其中27例痛经患者痛经评分:放置前(1.85±0.82)分,放置后1个月(0.48±0.51)

  4. Irregularidades menstruales y de hormonas sexuales en mujeres que se les diagnosticó la diabetes tipo 1 antes de la menarquia o después de esta Menstruation disorders and sexual hormones in women diagnosed with type 1 diabetes before menarche or after it

    Directory of Open Access Journals (Sweden)

    Yaquelín González Ricardo

    2010-04-01

    determine the sexual hormones levels and to establish the influence of this entity on the menarche age. METHODS: a cross-sectional descriptive study was conducted in 74 women aged 15 and 35, all seen in the Diabetes Care Center of Ciudad de La Habana, Cuba, which were distributed in two groups: A and B, both with n= 37; A: diagnosed with diabetes before the menarche appearance and B; after it. We designed a questionnaire of general data and puberal and menstrual medical records; we determined the presence of fasting glycemia, glycosylated hemoglobin and sexual hormones; both groups were compared using the t Student and chi² tests. RESULTS: we achieved a high frequency of dysmenorrhea, menorrhhea and premenstrual tension, as well the loss of a correlation among some sexual hormones. Earlier presence of type 1 diabetes mellitus determined a greater age of menarche, lower levels of gonadotropins (LH and FSH and oligomenorrhea. CONCLUSIONS: type 1 diabetes mellitus diagnosed before menarche seems to interfere with maturation and subsequent function of female gonadal axis, which conditioned a greater frequency of dysmenorrhea and menstrual irregularities.

  5. 少腹逐瘀汤临床应用研究进展%Research Progress of the Composition of Shaofu Zhuyu Decoction and Clinical Application

    Institute of Scientific and Technical Information of China (English)

    李业雷; 徐辉; 付梦佳

    2014-01-01

    Objective:To analysis Shaofu Zhuyu decoction efficacy of the composition and its clinical application .Methods: browse through an extensive recent literature magazine , organize collection of the relevant literature .Results:Shaofu Zhuyu decoction is widely used in clinical primary dysmenorrhea , chronic pelvic inflammatory disease , uterine bleeding , infertility and other gynecological disea-ses, chronic prostatitis, impotence, semen liquefaction psychosis male disease , lumbar disc herniation , ulcerative colitis and gastritis and other diseases .Conclusion:Shaofu Zhuyu decoction is widely used in clinical blood stasis treatment of pain and inflammation , re-flects the same drug treatment of different diseases ,"different diseases"in Chinese medical thought .%目的:对少腹逐瘀汤的临床应用研究进展作总结分析。方法:通过广泛浏览近期文献杂志,对有关文献进行收集整理。结果:少腹逐瘀汤在临床上广泛应用于原发性痛经、慢性盆腔炎、崩漏、不孕症等妇科疾病,慢性前列腺炎、阳痿、精液不液化症等男科疾病,腰椎间盘突出症,溃疡性结肠炎和胃炎等疾病。结论:少腹逐瘀汤在临床广泛应用于瘀血阻络性痛症及炎症的治疗,体现了以相同药物治疗不同疾病的“异病同治”的中医学思想。

  6. Hormonal treatment for endometriosis associated pelvic pain

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    Wu Shun Felix Wong

    2011-01-01

    Full Text Available AbstractBackground: Endometriosis is a common gynecological problem associated with chronic pelvic pain. Objective: To evaluate the effectiveness of current hormonal treatments of endometriosis associated pain.Materials and Methods: Randomized Controlled studies identified from databases of Medline and Cochrane Systemic Review groups were pooled. 7 RCTs were recruited for evaluation in this review. Data from these studies were pooled and meta-analysis was performed in three comparison groups: 1 Progestogen versus GnRHa; 2 Implanon versus Progestogen (injection; 3 Combined oral contraceptive pills versus placebo and progestogen. Response to treatment was measured as a reduction in pain score. Pain improvement was defined as improvement ≥1 at the end of treatment. Results: There was no significant difference between treatment groups of progestogen and GnRHa (RR: 0.036; CI:-0.030-0.102 for relieving endometriosis associated pelvic pain. Long acting progestogen (Implanon and Mirena are not inferior to GnRHa and depot medroxy progesterone acetate (DMPA (RR: 0.006; CI:-0.142-0.162. Combined oral contraceptive pills demonstrated effective treatment of relieving endometriosis associated pelvic pain when compared with placebo groups (RR:0.321CI-0.066-0.707. Progestogen was more effective than combined oral contraceptive pills in controlling dysmenorrhea (RR:-0.160; CI:-0.386-0.066, however, progestogen is associated with more side effects like spotting and bloating than the combined contraceptive pills. Conclusion: Combined oral contraceptive pills (COCP, GnRHa and progestogens are equally effective in relieving endometriosis associated pelvic pain. COCP and progestogens are relatively cheap and more suitable for long-term use as compared to GnRHa. Long-term RCT of medicated contraceptive devices like Mirena and Implanon are required to evaluate their long-term effects on relieving the endometriosis associated pelvic pain

  7. Intrauterine levonorgestrel delivery with frameless fibrous delivery system: review of clinical experience.

    Science.gov (United States)

    Wildemeersch, Dirk; Andrade, Amaury; Goldstuck, Norman D; Hasskamp, Thomas; Jackers, Geert

    2017-01-01

    The concept of using a frameless intrauterine device (IUD) instead of the conventional plastic framed IUD is not new. Frameless copper IUDs have been available since the late 1990s. They rely on an anchoring system to retain in the uterine cavity. The clinical experience with these IUDs suggests that frameless IUDs fit better as they are thin and, therefore, do not disturb or irritate the uterus. High tolerance and continuation rates have been achieved as complaints of pain are virtually nonexistent and the impact on menstrual blood loss is minimal. Conventional levonorgestrel-releasing intrauterine systems (LNG-IUSs) are very popular as they significantly reduce menstrual bleeding and provide highly effective contraception. However, continuation of use remains problematic, particularly in young users. Total or partial expulsion and displacement of the LNG-IUS also occur too often due to spatial incompatibility within a small uterine cavity, as strong uterine contractions originate, attempting to get rid of the bothersome IUD/IUS. If not expelled, embedment ensues, often leading to chronic pain and early removal of the IUD/IUS. Several studies conducted recently have requested attention to the relationship between the LNG-IUS and the endometrial cavity. Some authors have proposed to measure the cavity width prior to inserting an IUD, as many uterine cavities are much smaller than the currently existing LNG-IUSs. A frameless fibrous drug delivery system fits, in principle, in all uterine cavities and may therefore be preferable to framed drug delivery systems. This review examines the clinical performance, acceptability, and potential of the frameless LNG-IUS (FibroPlant(®)) when used for contraception, treatment of heavy menstrual bleeding, dysmenorrhea, and endometrial suppression in women using estrogen replacement therapy, endometrial hyperplasia, and other gynecological conditions. The review concludes that FibroPlant LNG-IUS offers unique advantages in

  8. Cornual pregnancy as a complicaton of the use of a levonorgestrel intrauterine device: a case report

    Directory of Open Access Journals (Sweden)

    Beltman JJ

    2009-07-01

    Full Text Available Abstract Introduction Complications of copper load intrauterine devices, including ectopic pregnancies are well reported. Rates of ectopic pregnancy are 0.6 to 1.1% per year. However, the levonorgestrel intrauterine device has been described as more protective against ectopic pregnancies due to the addition of the hormone levonorgestrel. The hormone released from the intrauterine device causes some systemic effects, but local effects such as glandular atrophy and stromal decidualization, in addition to foreign body reaction, are dominant. Few case reports have described ampullary ectopic pregnancies. However, we report, for the first time, a major complication of levonorgestrel intrauterine device: a cornual pregnancy. Case presentation A 36-year-old Caucasian nulliparous woman presented with complaints of progressive nausea, abdominal pain and irregular vaginal bleeding for 2 months. For 3 years, she had been using a levonorgestrel intrauterine device. A two-dimensional transvaginal sonogram noted a sac situated external to the endometrial cavity in the right cornua of the uterus with an empty uterus. She was successfully treated with chemotherapy. Conclusion Many complications have been described, including ectopic pregnancies, using copper intrauterine devices. The levonorgestrel-releasing intrauterine system is a particularly good choice for adolescents because of associated non-contraceptive benefits such as decreased menstrual bleeding, dysmenorrhea and pain associated with endometriosis 1. Yet a cornual pregnancy following the use of a levonorgestrel intrauterine device is a complication which, to our knowledge, has not been described before. Physicians prescribing this type of intrauterine device should be aware of this rare event.

  9. Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine

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    Dong-Yi eHe

    2011-02-01

    Full Text Available In China, Korea and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of paeony (TGP, which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotrience B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of pro-inflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

  10. Improving accuracy of intraoperative diagnosis of endometriosis: Role of firefly in minimal access robotic surgery

    Directory of Open Access Journals (Sweden)

    John R Lue

    2016-01-01

    Full Text Available Endometriosis continues to be a major primary gynecologic etiology of chronic pelvic pain. The symptom profile, which includes cyclic pelvic pain, dysmenorrhea, and dyspareunia or dyschezia, is nonspecific and does not correlate with the extent or severity of disease. Trans-vaginal or trans-rectal ultrasound, as well as magnetic resonance imaging, can help visualize endometriomas and deeply infiltrating endometriosis. Additionally, there have been no serum marker tests available so far. However, even intraoperatively, the diagnosis may be missed, leading to under diagnosis and delayed or noninitiation of treatment. There are thought to be three distinct endometriotic lesions of the pelvis that are seen laparoscopically. The first is that which is visible on the pelvic peritoneal surface or the surface of the ovary, which is commonly termed peritoneal endometriosis. Second, endometriotic lesions that occur within the ovary and form cysts that are often lined with endometrioid mucosa are termed endometriomas. Lastly, rectovaginal endometriomas are endometriotic lesions that contain a mixture of adipose and fibrous tissue located between the rectum and vagina. All of these lesions can be singular or multiple and the pelvis may contain one or all three types of lesions. The shared histologic feature with all three lesions is the presence of endometrial epithelial cells or endometrial stroma. During a diagnostic procedure, the da-Vinci robot and its firefly mode allow for three dimensional visualization and seven degrees of instrument articulation for meticulous dissection of fibrotic areas of peritoneum that may contain deep infiltrating lesions of endometriosis. This case report describes a relatively new and innovative technique for effectively diagnosing and successfully treating endometriosis when other less invasive methods have failed.

  11. Relationship Analysis between Pelvic Pain and Pathological Changes of Patients with Endometriosis%子宫内膜异位症患者盆腔疼痛与病变的关系分析

    Institute of Scientific and Technical Information of China (English)

    于翠革

    2015-01-01

    目的:分析子宫内膜异位症患者盆腔疼痛与病变之间的关系。方法:选取2013年2月~2015年2月100例子宫内膜异位症患者进行治疗,主要对患者的病变发生位置、盆腔粘连、类型、浸润程度等进行分析,探讨其盆腔疼痛与病变的关系。结果:轻度粘连者性交疼痛、排便痛/肛门坠胀发生率及痛经程度均显著优于中、重度粘连者(P<0.05)。结论:子宫内膜异位症盆腔疼痛与粘连程度相关,因此将病灶完全切除才能有效解决疼痛问题。%Objective:To analyze the relationship between pelvic pain and pathological changes of patients with endometriosis. Methods:100 cases of patients with endometriosis selected from February 2015 to February 2013 were treated, the location of lesions, pelvic adhesion, type and degree of invasion were mainly analyzed, to explore the relationship between pelvic pain and pathological changes. Results:Dyspareunia, incidence of defeca-tion pain or anus bulge and dysmenorrhea degree of mild adhesion were significantly superior to those of moderate and severe adhesions (P<0.05). Conclusion:Pelvic pain of endometriosis is associated with adhesion degree, so only lesions completely removed can effectively solve the problem of pain.

  12. Comparing the effects of aerobic exercise and Foeniculum vulgare on pre-menstrual syndrome

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    Hassan Pazoki

    2016-03-01

    Full Text Available Introduction: Premenstrual syndrome (PMS has been identified by a number of psychological and physical symptoms which occur cyclically in the luteal phase of the menstrual cycle. The present study has been carried out to compare the effects of regular exercise and Foeniculum vulgare extract (fennel together and separately on PMS in high school girls. Materials and methods: In this randomized clinical trial 48 students aged 16–18 years were selected by filling the daily record of severity of problem questionnaire (DRSP-Q. The participants were divided into four equal groups: the first group received fennel, the second group had aerobic exercise, the third group received fennel along with exercise and the last group was control group without fennel and exercise. Participants filled DRSP-Q three times: the first menstrual cycle before the intervention, the first menstrual cycle after four weeks and finally the first menstrual cycle after eight weeks of intervention. Results: After 8 weeks of intervention the severity of PMS symptoms reduced significantly in experimental groups (fennel, exercise and fennel + exercise compared to control group (P < 0.05. Meanwhile, there were not any significant differences in age, body mass index, age at menarche, age at dysmenorrhea onset and duration of menstruation among the four groups. Discussions: The result of this study indicated that fennels and exercise could reduce the severity of premenstrual syndrome. In addition, fennel extract and exercise together seem to be more effective on symptoms of anxiety and depression compared with using them alone.

  13. 血管内皮生长因子及其受体与功能失调性子宫出血的研究进展%Research Progress of Vascular Endothelial Growth Factor and Its Receptor and Dysfunctional Uterine Bleeding

    Institute of Scientific and Technical Information of China (English)

    张志革

    2012-01-01

    Vascular endothelial growth factor( VEGF )is a strong angiogenesis accelerator with extremely high expression in endometrial glands of women with anovulatory dysfunctional uterine bleeding,which is cyclically expressed and regulated by many fsctors. Researches in the last 10 years showed that VEGF was related to abnormal uterine bleeding,infertility,dysmenorrhea and other gynecological diseases,especially that tt has been paid much attention to the role of VEGF in the occurrence of abnormal uterine bleeding. Here is to make a review on the physical and chemical characteristics,mechanism,influencing factors and the effect of VEGF and its receptor in dysfunctional uterine bleeding.%血管内皮生长因子是一种极强的血管生成促进剂,在无排卵性功能失调性子宫出血妇女子宫内膜腺体中浓度极高,呈周期性表达,受多种因素的调控.近10年来研究发现,血管内皮生长因子与女性异常子宫出血、不孕、痛经等疾病相关,尤其是它在异常子宫出血的发病过程中所起的作用备受关注.现就血管内皮生长因子及其受体的理化特征、作用机制、影响因素及其在功能失调性子宫出血发病过程中的作用进行综述.

  14. Social Determinants and Reproductive Factors of the Menopausal Symptoms among Women in Tabriz-Iran

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    Mahasti Alizadeh

    2015-01-01

    Full Text Available Background: Menopause is a natural event in which different degrees of psychosomatic changes occur. The social, demographic and behavioral factors in different nations have a significant effect on symptoms of menopause. The aim of this study was to determine the relationship between the personal, demographic, social and reproductive factors with symptoms of menopause and the frequency of the mental and physical symptoms of menopause among women in Tabriz, Northwest of Iran.   Methods: A cross-sectional study was conducted in the clinics and health centers of Tabriz, East Azerbaijan and Iran. A total of 300 women aged 40-60 years filled a questionnaire on the socio demographic variables, reproductive history and symptoms checklist.  Results: Among the symptoms, muscle and joint pain (68.7%, and increased facial hair (20.5% were the most and the least common ones respectively. According to participants, as age increases, the symptoms worsen (p=0.003. The frequency of the symptoms of the employed women was less than those of retired ones and housewives (p=0.001. The physical and mental symptoms had negative relation with educational status (p<0.05. An increase in the number of the children, the history of the oral contraceptive use and dysmenorrhea had positive relation with the frequency of the symptoms.  Conclusion: The quality of life of the women during menopause worsens with an increase in age and number of children, whereas it improves with higher educational levels and employment.

  15. Research Advances of Endometriosis Relative Genes%子宫内膜异位症相关基因研究进展

    Institute of Scientific and Technical Information of China (English)

    张春斌; 常春艳; 刘爽; 谈西满; 胡玉红; 张金波; 罗佳滨

    2009-01-01

    Endometriosis is a chronic recurrent and progressive disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 15% of women of child-bearing age. It can cause dyspareunia, pelvic pain, dysmenorrhea, and infertility. Although the etiology of endometriosis is unknown, several hypotheses have been proposed to explain its origin. Recently,genetic factors are thought to contribute to the development of this disease, and polygene/multiple factor theory has been accepted generally. This article presents an overview of research advancement of genes related to endometriosis, including gene polymorphism and abnormal expression of gene product. We try to explain the developmental mechanism of endometriosis from the angle of molecular genetics.%子宫内膜异位症(内异症)是一种易复发并具有侵袭性的慢性疾病,特点是有生长功能的子宫内膜腺上皮腺体和间质细胞出现在正常子宫体腔内膜以外,可以影响约15%生育年龄的妇女,引起性交痛、盆腔疼痛、痛经和不孕.目前内异症病因不清,已经提出几种假说解释它的发生机制,研究认为遗传因素在内异症的发生发展中起作用,多基因/多因素理论已经被广泛接受.本文对内异症相关基因多态性和基因产物异常表达的研究加以分析,试图从分子遗传学角度解释内异症发生发展的机制.

  16. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids.

    Science.gov (United States)

    Kidd, Parris M

    2007-09-01

    The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are orthomolecular, conditionally essential nutrients that enhance quality of life and lower the risk of premature death. They function exclusively via cell membranes, in which they are anchored by phospholipid molecules. DHA is proven essential to pre- and postnatal brain development, whereas EPA seems more influential on behavior and mood. Both DHA and EPA generate neuroprotective metabolites. In double-blind, randomized, controlled trials, DHA and EPA combinations have been shown to benefit attention deficit/hyperactivity disorder (AD/HD), autism, dyspraxia, dyslexia, and aggression. For the affective disorders, meta-analyses confirm benefits in major depressive disorder (MDD) and bipolar disorder, with promising results in schizophrenia and initial benefit for borderline personality disorder. Accelerated cognitive decline and mild cognitive impairment (MCI) correlate with lowered tissue levels of DHA/EPA, and supplementation has improved cognitive function. Huntington disease has responded to EPA. Omega-3 phospholipid supplements that combine DHA/EPA and phospholipids into the same molecule have shown marked promise in early clinical trials. Phosphatidylserine with DHA/EPA attached (Omega-3 PS) has been shown to alleviate AD/HD symptoms. Krill omega-3 phospholipids, containing mostly phosphatidylcholine (PC) with DHA/EPA attached, markedly outperformed conventional fish oil DHA/EPA triglycerides in double-blind trials for premenstrual syndrome/dysmenorrhea and for normalizing blood lipid profiles. Krill omega-3 phospholipids demonstrated anti-inflammatory activity, lowering C-reactive protein (CRP) levels in a double-blind trial. Utilizing DHA and EPA together with phospholipids and membrane antioxidants to achieve a triple cell membrane synergy may further diversify their currently wide range of clinical applications.

  17. Noncontraceptive benefits of the estradiol valerate/dienogest combined oral contraceptive: a review of the literature

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    Nappi RE

    2014-08-01

    Full Text Available Rossella E Nappi,1 Marco Serrani,2 Jeffrey T Jensen3 1Department of Obstetrics and Gynecology, Research Centre for Reproductive Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy; 2Global Medical Affairs Women's Healthcare, Bayer HealthCare Pharmaceuticals, Berlin, Germany; 3Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA Abstract: Combined oral contraceptives formulated to include estradiol (E2 have recently become available for the indication of pregnancy prevention. A combined estradiol valerate and dienogest pill (E2V/DNG, designed to be administered using an estrogen step-down and a progestin step-up regimen over 26 days of active treatment followed by 2 days of placebo (26/2-day regimen, has also undergone research to assess the potential for additional noncontraceptive benefits. Randomized, placebo-controlled studies have demonstrated that E2V/DNG is an effective treatment for heavy menstrual bleeding – a reduction in median menstrual blood loss approaching 90% occurs after 6 months of treatment. To date, E2V/DNG is the only oral contraceptive approved for this indication. Comparator studies have also demonstrated a reduction in hormone withdrawal-associated symptoms in users of E2V/DNG compared with a conventional 21/7-day regimen of ethinylestradiol/levonorgestrel. Other potential noncontraceptive benefits associated with E2V/DNG, like improvement in dysmenorrhea, sexual function, and quality of life, are comparable with those associated with other combined oral contraceptives and are discussed further in this review. Keywords: heavy menstrual bleeding, hormone withdrawal-associated symptoms, quality of life

  18. A chewable low-dose oral contraceptive: a new birth control option?

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    Weisberg E

    2012-04-01

    Full Text Available Edith Weisberg1,21Sydney Centre for Reproductive Health Research, Research Division of Family Planning NSW, 2Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, AustraliaAbstract: A new chewable combined oral contraceptive pill containing ethinyl estradiol (EE 0.025 mg and norethindrone (NE 0.8 mg in a 24/4 regimen was approved for marketing in December 2010. Each of the four inactive tablets contains 75 mg ferrous fumarate, which has no therapeutic benefit. The tablet can be taken with food but not water as this affects the absorption of EE. The Pearl index based on intention to treat women aged 18–35 years has been reported at 2.01 (confidence interval [CI] 1.21, 3.14 and for the whole population 1.65 (CI 1.01, 2.55. The effect of a body mass index of >35 was not studied. Regular withdrawal bleeding occurred for 78.6% of women in Cycle 1, but by Cycle 13 almost half the women failed to have a withdrawal bleed. This new formulation provides an intermediate dose of an EE/NE combination that will be useful for women experiencing breakthrough bleeding on the lower-dose EE/NE pill. The convenience of a low-dose pill, which can be chewed without the need for water, will be useful to enable women who have forgotten a pill to take one whenever they remember, provided they carry it with them. The advantage of a 24/4 regimen is better suppression of follicular development in the pill-free interval and may be beneficial for women who experience menstrual cycle-related problems, such as heavy bleeding or dysmenorrhea.Keywords: combined oral contraceptive, low dose, ethinyl estradiol, norethindrone

  19. Onset of menstrual cycle and menses features among secondary school girls in Italy: A questionnaire study on 3,783 students

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    Vincenzo De Sanctis

    2014-01-01

    Full Text Available Premise: Healthcare professionals need updated information about what is the range of "normal" variation of menstrual cycle features to support young girls and their parents in managing reproductive health, and to detect diseases early. Materials and Methods: This cross-sectional study aimed to provide an updated picture of age at menarche and main menstrual cycle characteristics and complaints in an Italian population-based sample of 3,783 adolescents attending secondary school. Girls filled in a self-administered anonymous questionnaire including questions about demography, anthropometry, smoking and drinking habits, use of contraceptive, socioeconomic status, age at menarche, menstrual pattern, and physical/psychological menstrual complaints. Mean age at menarche and prevalence of polymenorrhea (cycle length 35 days, irregularity, dysmenorrhea, and of physical/psychological complaints were computed. Factors associated with age at menarche and menstrual disturbances were explored by using multiple logistic models. Results: The girls′ mean age was 17.1 years (SD 1.4 years and the mean age at menarche was 12.4 years (SD 1.3 years; menarche occurred with two monthly peaks of frequency in July-September and in December-January (P 6 days was shown in 19.6% of girls. Gynecological age was significantly associated with cycle length (P < 0.0001 with long cycles becoming more regular within the fourth year after menarche, while frequency of polymenorrhea stabilized after the second gynecological year. Oligomenorrhea and irregularity were both significantly associated with long menstrual bleeding (adjusted OR = 2.36; 95% CI = 1.55-3.60, and adjusted OR = 2.59; 95% CI = 1.95-3.44, respectively. Conclusions: The findings of the study support the levelling-off of secular trend in menarche anticipation in Italy and confirm the timing in menstrual cycle regularization. The study provides updated epidemiological data on frequency of menstrual abnormalities

  20. Clinical research on the efficacy of Mirena in combined with mifepristone in the treatment of adenomyosis

    Institute of Scientific and Technical Information of China (English)

    Li-Juan Cao; Xin-Jun Shu

    2016-01-01

    Objective:To observe the clinical effect of levonorgestrel slow-release system (LNG-IUS, Mirena) in combined with mifepristone in the treatment of adenomyosis (AM). Methods:A total of 76 patients with AM who were admitted in our hospital from January, 2013 to January, 2015 were included in the study and randomized into the treatment group and the control group with 38 cases in each group. The patients in the treatment group were given Mirena in combined with mifepristone, while the patients in the control group were only placed with Mirena. The changes of symptoms and sex hormone levels before and after treatment between the two groups were compared. B ultrasound was used to examine the uterine volume and intimal thickness. Results:The comparison of menstrual cycle before and after treatment between the two groups was not statistically significant. After treatment, the menstrual duration in the two groups was significantly shortened when compared with before treatment, PBAC and VAS scores were significantly reduced. The improvement degree of dysmenorrhea after treatment in the treatment was significantly superior to that in the control group. The endometrial thickness and uterine volume after treatment in the two groups were significantly reduced when compared with before treatment, but the comparison between the two groups was not statistically significant. The serum CA125 after treatment in the treatment group was significantly lower than that in the control group. The comparison of LH, FSH, and E2 levels before and after treatment between the two groups was not statistically significant. Conclusions:Mirena in combined with mifepristone in the treatment of AM can effectively alleviate the clinical symptoms with no effect on sex hormone levels;therefore, it deserves to be widely recommended in the clinic.

  1. Intrauterine levonorgestrel delivery with frameless fibrous delivery system: review of clinical experience

    Science.gov (United States)

    Wildemeersch, Dirk; Andrade, Amaury; Goldstuck, Norman D; Hasskamp, Thomas; Jackers, Geert

    2017-01-01

    The concept of using a frameless intrauterine device (IUD) instead of the conventional plastic framed IUD is not new. Frameless copper IUDs have been available since the late 1990s. They rely on an anchoring system to retain in the uterine cavity. The clinical experience with these IUDs suggests that frameless IUDs fit better as they are thin and, therefore, do not disturb or irritate the uterus. High tolerance and continuation rates have been achieved as complaints of pain are virtually nonexistent and the impact on menstrual blood loss is minimal. Conventional levonorgestrel-releasing intrauterine systems (LNG-IUSs) are very popular as they significantly reduce menstrual bleeding and provide highly effective contraception. However, continuation of use remains problematic, particularly in young users. Total or partial expulsion and displacement of the LNG-IUS also occur too often due to spatial incompatibility within a small uterine cavity, as strong uterine contractions originate, attempting to get rid of the bothersome IUD/IUS. If not expelled, embedment ensues, often leading to chronic pain and early removal of the IUD/IUS. Several studies conducted recently have requested attention to the relationship between the LNG-IUS and the endometrial cavity. Some authors have proposed to measure the cavity width prior to inserting an IUD, as many uterine cavities are much smaller than the currently existing LNG-IUSs. A frameless fibrous drug delivery system fits, in principle, in all uterine cavities and may therefore be preferable to framed drug delivery systems. This review examines the clinical performance, acceptability, and potential of the frameless LNG-IUS (FibroPlant®) when used for contraception, treatment of heavy menstrual bleeding, dysmenorrhea, and endometrial suppression in women using estrogen replacement therapy, endometrial hyperplasia, and other gynecological conditions. The review concludes that FibroPlant LNG-IUS offers unique advantages in reducing

  2. 子宫腺肌瘤保守性治疗效果分析%Effect Analysis of the Conservative Treatment of Uterine Adenomyoma

    Institute of Scientific and Technical Information of China (English)

    黄华仪; 覃碧芳

    2012-01-01

    Objective:Explored the clinical efficacy of Adenomyosis laparoscopic resection of uterine home Mirena. Methods:Retrospectived analysis of 50 cases of uterine adenomyosis patients, acceptance of laparoscopic uterine gland myomectomy uterine home Mirena in 29 patients (study group), laparoscopic uterine adenomyoma excision combined with oral Marvelon patients21 cases (control group).Results:Observation group were dysmenorrhea relief and reduction in menstrual flow with the control group were significantly different (P<0.05).Conclusion:Treatmented to retain the uterus Adenomyosis laparoscopic resection cavity set Man Month music, not only eased the symptoms, but also to retain the uterus and reproductive function.%目的:探讨子宫腺肌瘤腹腔镜切除术宫腔置曼月乐的临床疗效.方法:回顾性分析本院50例子宫腺肌瘤患者,接受腹腔镜子宫腺肌瘤切除术宫腔置曼月乐患者29例(观察组),接受腹腔镜子宫腺肌瘤切除术结合口服妈富隆患者21例(对照组).结果:观察组术后痛经程度缓解及月经量减少与对照组有显著差异(P<0.05).结论:保留子宫的子宫腺肌瘤腹腔镜切除术宫腔置曼月乐的治疗方法,既缓解了症状,又保留了子宫及生育功能.

  3. Awareness of menstrual abnormality amongst college students in urban area of Ile-Ife, Osun State, Nigeria

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    Esimai O

    2010-01-01

    Full Text Available Background: Disturbances of menstrual bleeding are major social and medical problem for women and account for high percentage of gynecological visit. Objectives: The objective of the study was to document menstrual abnormalities experienced by female college students, their awareness and health seeking behavior. Materials and Methods: A cross-sectional survey was undertaken, 400 students were selected using stratified sampling technique and interviewed using semi-structured self-administered questionnaire. Inferential statistical analysis such as Chi-square test and logistic regressions were carried out. Results: The mean age at menarche was 14.18 years. Irregular menstrual cycles were reported in 9.0%. Dysmenorrhea was present in 62.5%, and 12.5% reported school absenteeism. Students′ awareness of menstrual abnormalities was poor (29%. A few of them (10.5% decided to seek help for menstrual abnormalities. The awareness of students on menstrual abnormalities was significantly influenced by their age (OR = 2.33, P = 0.03; however, age at menarche and level of study did not influence their awareness (OR = 0.45, P = 0.24 and OR = 1.42, P = 0.12. History of dysmenorrheal (OR = 10.2, P = 0.001 and academic disturbance (OR = 5.45, P = 0.001 had significant influence on the health seeking behavior of the students. Conclusion: There was a general lack of information about menstrual issues and when to seek help. There is a need to educate female college students about menstrual issues in order to improve their health seeking behavior as regards menstrual abnormalities.

  4. Effects of fufang yimucao oral liquid on acute ache model mice

    Institute of Scientific and Technical Information of China (English)

    Fengjie Wang; Mingsan Miao; Yulin Zhang; Jingjing Shi; Yalei Yang; Huili Liu

    2007-01-01

    BACKGROUND: Fufang yimucao oral liquid has markedly effects on ameliorating circulation, restraining uterine constriction induced by oxytocin, alleviating dysmenorrhea, as a traditional medicine on promoting blood circulation by removing blood stasis, yimucao could ameliorate abnormal hemorrheological when hemorrhagic shock happens, enhance the hemoperfusion of organs and actively react on the result of hemorrhagic shock. OBJECTIVE: To investigate the abirritation of fufang yimucao oral liquid on pain model mice induced by hot board method and acetic acid twist body method and dysmenorrhea model mice induced by estradiol. DESIGN: Entirely randomly grouping and control experiment.SETTING: Pharmacological Laboratory, Henan College of Traditional Chinese Medicine. MATERIALS: A total of 200 female Kunming genus mice of grade 2 and weighing 18-21 g were collected. Fufang yimucao oral liquid, mainly consist of yimucao, danggui, chuanxiong, muxiang, and so on, was produced by Henan Joyline&Joysun Pharmaceutical Stock Co., Ltd. (batch number: 050701); yimucao oral liquid was produced by Shangqiu Lvyuan Pharmaceutical Co., Ltd. (batch number: 050108); estradiol slice by Shanghai Xinyi Kangjie Pharmaceutical Co., Ltd. (batch number: 050301); YSL-6A intelligence hot plate instrument by Shandong Equipments Station of the Medical Science.METHODS:The experiment was carried out in the Animal Experiment Center of the Henan College of Traditional Chinese Medicine from August to November 2005. The high-, middle- and low-dosage fufang yimucao oral liquid in the experiment was 1, 0.5 and 0.25 in volume fraction, respectively, and yimucao oral liquid was 0.5.①Among 80 mice, 60 mice were eligible in pain threshold tested by hot plate, and randomly dividing into 5 groups with 12 in each group. Mice in the high-, middle- and low-dose fufang yimucao oral liquid groups were perfused with 1 mL, 0.5 mL and 0.25 mL/mL fufang yimucao, and mice in the yimucao group and saline group were

  5. High prevalence of chronic pelvic pain in women in Ribeirão Preto, Brazil and direct association with abdominal surgery

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    Gabriela Pagano de Oliveira Goncalves da Silva

    2011-01-01

    Full Text Available INTRODUCTION: Chronic pelvic pain is a disease that directly affects the social and professional lives of women. OBJECTIVE: To estimate the prevalence of this clinical condition and to identify independent factors associated with it in women living in Ribeirão Preto, Brazil. METHODS: A one-year cross-sectional study was conducted in a population sample of 1,278 women over the age of 1,278 women over the age of 14 years. The target population was predominantly composed of women who are treated by the public health system. The questionnaire was administered by interviewers who were not linked to the city health care programs. The prevalence of the morbidity was estimated. First, we identified the significant variables associated with pelvic pain (p<0.10 and then we attributed values of 0 or 1 to the absence or presence of these variables. Logistic regression analysis was used to identify and estimate the simultaneous impact of the independent variables. The results were expressed by odds ratio and their 95% confidence interval with p<0.05. RESULTS: The disease was found in 11.5% (147/1,278 of the sample. The independent predictors were dyspareunia, previous abdominal surgery, depression, dysmenorrhea, anxiety, current sexual activity, low back pain, constipation, urinary symptoms, and low educational level. CONCLUSION: The prevalence of chronic pelvic pain in Ribeirão Preto is high and is associated with conditions that can usually be prevented, controlled, or resolved by improvement of public health policies and public education.

  6. Prevalence and conditions associated with chronic pelvic pain in women from São Luís, Brazil

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    L.S.C. Coelho

    2014-09-01

    Full Text Available The objective of the present study was to estimate the prevalence of chronic pelvic pain in the community of São Luís, capital of the State of Maranhão, Northeastern Brazil, and to identify independent conditions associated with it. A cross-sectional study was conducted, including a sample of 1470 women older than 14 years predominantly served by the public health system. The interviews were held in the subject's home by trained interviewers not affiliated with the public health services of the municipality. The homes were visited at random according to the city map and the prevalence of the condition was estimated. To identify the associated conditions, the significant variables (P=0.10 were selected and entered in a multivariate analysis model. Data are reported as odds ratio and 95% confidence interval, with the level of significance set at 0.05. The prevalence of chronic pelvic pain was 19.0%. The independent conditions associated with this diagnosis were: dyspareunia (OR=3.94, premenopausal status (OR=2.95, depressive symptoms (OR=2.33, dysmenorrhea (OR=1.77, smoking (OR=1.72, irregular menstrual flow (OR=1.62, and irritative bladder symptoms (OR=1.90. The prevalence of chronic pelvic pain in Sao Luís is high and is associated with the conditions cited above. Guidelines based on prevention and/or early identification of risk factors may reduce the prevalence of chronic pelvic pain in São Luís, Brazil.

  7. Rapid rehabilitation programme following sacral stress fracture in a long-distance running female athlete.

    Science.gov (United States)

    Knobloch, Karsten; Schreibmueller, Louisa; Jagodzinski, Michael; Zeichen, Johannes; Krettek, Christian

    2007-11-01

    Stress fractures occur in normal bone due to mechanical overload by cyclic stress increasing the osteoclastic activity, thus facilitating weakening leading to fracture of bones. Long-distance running may lead to stress fractures of the mid- and distal tibia and of the metatarsal bones. Stress fractures to the sacrum are rare. Certain factors for stress fractures in runners have been identified, such as leg-length inequality, a high longitudinal arch of the foot, forefoot varus, and menstrual irregularities in case of female athlete triad. We report on a 22-year-old female runner (usually training 140 km/week) suffering a sacral fatigue-type fracture. The female athlete triad with eating disorders, dysmenorrhea, and osteopenia was ruled out. Sexual hormone blood samples proofed normal values. The diagnosis was performed using magnetic resonance imaging 2 weeks after the onset of buttock pain. A conservative treatment regimen was initiated with strict physical rest for the first 2 weeks, and then gradual increase of physical activity with 60-90 min of daily cycling and moderate 2 x 60 min cross-training. After another 2 weeks time, daily 60-90 min of walking, Nordic pole walking, and moderate strength training two times a week was performed. At 7 weeks running was started, gradually increased to 90 km/week without any pain. A rapid rehabilitation programme after sacral stress fractures involving low impact physical activity, such as Walking and Nordic pole walking, is applicable to female athletes after ruling out the female athlete triad.

  8. Estrogenic and progestagenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS.

    Science.gov (United States)

    Locklear, Tracie D; Huang, Yue; Frasor, Jonna; Doyle, Brian J; Perez, Alice; Gomez-Laurito, Jorge; Mahady, Gail B

    2010-07-01

    To investigate the biological activities of Justicia pectoralis Jacq. (Acanthaceae), an herbal medicine used in Costa Rica (CR) for the management of menopausal symptoms and dysmenorrhea. The aerial parts of J. pectoralis were collected, dried and extracted in methanol. To establish possible mechanisms of action of JP for the treatment of menopausal symptoms, the estrogenic and progesterone agonists, and antiinflammatory activities were investigated. The methanol extract (JP-M) was tested in ER and PR binding assays, a COX-2 enzyme inhibition assay, the ERbeta-CALUX assay in U2-OS cells, as well as reporter and endogenous gene assays in MCF-7 K1 cells. The JP-M extract inhibited COX-2 catalytic activity (IC(50) 4.8 microg/mL); bound to both ERalpha and ERbeta (IC(50) 50 microg/mL and 23.1 microg/mL, respectively); induced estrogen-dependent transcription in the ERbeta-CALUX; and bound to the progesterone receptor (IC(50) 22.8 microg/mL). The extract also modulated the expression of endogenous estrogen responsive genes pS2, PR, and PTGES in MCF-7 cells at a concentration of 20 microg/mL. Activation of a 2 ERE-construct in transiently transfected MCF-7 cells by the extract was inhibited by the estrogen receptor antagonist ICI 182,780, indicating that the effects were mediated through the estrogen receptor. Finally, the extract weakly enhanced the proliferation of MCF-7 cells, however this was not statistically significant as compared with DMSO controls. Extracts of J. pectoralis have estrogenic, progestagenic and anti-inflammatory effects, and thus have a plausible mechanism of action, explaining its traditional use for menopause and PMS. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  9. Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

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    Guo, Song; Lu, Xiaowei; Gu, Ruihuan; Zhang, Di; Sun, Yijuan; Feng, Yun

    2017-01-01

    Purpose Adenomyosis is a common, benign gynecological condition of the female reproductive tract characterized by heavy menstrual bleeding and dysmenorrhea. Gonadotropin-releasing hormone (GnRH) agonists are one of the medications used in adenomyosis treatment; however, their underlying mechanisms are poorly understood. Moreover, it is difficult to obtain endometrial samples from women undergoing such treatment. To overcome this, we generated an adenomyosis mouse model, which we treated with an GnRH agonist to determine its effect on pregnancy outcomes. We also analyzed endometrial gene expression following GnRH agonist treatment to determine the mechanisms that may affect pregnancy outcome in individuals with adenomyosis. Methods Neonatal female mice were divided into a control group, an untreated adenomyosis group, and an adenomyosis group treated with a GnRH agonist (n=6 each). The pregnancy outcome was observed and compared among the groups. Then, three randomly chosen transcriptomes from endometrial tissues from day 4 of pregnancy were analyzed between the adenomyosis group and the GnRH agonist treatment group by RNA sequencing and quantitative reverse transcription polymerase chain reaction (PCR). Results The litter size was significantly smaller in the adenomyosis group than in the control group (7±0.28 vs 11±0.26; Ppregnancy outcome of adenomyosis in a mouse model. Besides pituitary down-regulation, other possible mechanisms such as the regulation of cell proliferation may play a role in this. These new insights into GnRH agonist mechanisms will be useful for future adenomyosis treatment. PMID:28331289

  10. The prevalence of female sexual dissatisfaction and the dominant risk factors that may impair sexual satisfaction in Malaysian women

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    Hatta Sidi

    2007-09-01

    Full Text Available The study aims were to investigate the prevalence of sexual dissatisfaction and the potential risk factors. This was a cross-sectional study on women attending primary care setting in Malaysia over a period of March to June 2005, and used a non-probability sampling method. A validated questionnaire for sexual function was used. A total of 230 married women aged 21 – 62 years old participated in this study. The ressults show that the majority of the respondents were less than 45 years old, predominantly Malays, and with higher academic achievement. We noted that 52.2% (120/230 study subjects had sexual dissatisfaction. Race, salary, education level, medical problems, dysmenorrhea, and menacrhe were likely not correlated with sexual dissatisfaction. The dominant risk factor related to sexual dissatisfaction was age of husband. In additional, sexual dissatisfaction was moderately (P = 0.077 related to sexual per month. The subjects who had their husbands aged 43-75 years compared with 24-42 years had 68% increased risk to experience sexual dissatisfaction [adjusted relative risk (RRa = 1.68; 95% confidence interval (CI = 1.15 - 2.44]. In term of sexual frequency per month, those who had 1-3 times per month than 4-5 times per month had two-fold increased risk to experience sexual dissatisfaction (RRa = 2.03; 95% CI = 0.93-4.42; p = 0.077. In conclusion, the prevalence of sexual dissatisfaction was very high in Malaysian primary care population and it was strongly associated with women who married to an older husband and with infrequent sexual activity. (Med J Indones 2007; 16:187-94 Keywords: sexual dissatisfaction, age of husbands, malaysian women

  11. A study of nutritional status and high risk behavior of adolescents in Ahmedabad: A Cross Sectional Study

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    Mital Prajapati

    2011-01-01

    Full Text Available Background: Adolescence is a distinct age group (10-19 yrs with complex needs because of physical and psychological development during puberty. Aim: To evaluate adolescents’ nutritional status and high risk behavior. Settings and design: A Cross Sectional study was conducted in West Zone of Ahmedabad Municipal Corporation, Gujarat. Methods & Material: 401 students (10-19years from 10 schools and colleges surveyed using pretested questionnaire about nutritional status and high risk behavior. To analyze nutritional status height, weight and BMI were taken and analyzed using WHO growth standards 2007. Statistical analysis: Qualitative data analysis done using Epi Info and WHO Anthro Plus softwares. Results: 47.4% (95% CI= 30.7% - 64.6% were stunted and 19.5% (95%CI=12.6% - 28.7% were overweight according to WHO growth standards 2007. Awareness about HIV/AIDS was 93.27% and main media of awareness was television(55.35%. 13.22% were sexually active and 35.85% used condoms during last sexual act. 22.56% have habit of masturbation. 25.19% students believe masturbation is bad habit. Only boys (15.9% had addiction and common was tobacco chewing (61.29%. No one was Intravenous Drug User. Mean age for menarche was 12.84 yrs. From them 60.93% have problems during menstruation. Most common problem was dysmenorrhea (58.7%. For discussing sexual health problems, 74.64% students prefer with friends. Conclusions: Adolescents have many health problems that need to be taken care of by effective interventions. Key message: Nationwide adolescent health data is inadequate. Focus must be given on analyzing adolescent health issues and to solve them.

  12. Analysis on Risk and Protective Factors Related to Premature Ovarian Failure

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    Peng-li LI

    2015-09-01

    Full Text Available Objective: To investigate the risk and protective factors related to premature ovarian failure (POF. Methods: A total of 168 patients with POF inFuning County Hospital of TCM were selected as POF group, and another 42 POF-free patients served as control group at the same term. The patients in both groups were inquired in details by investigators in the form of questionnaire, and the relevant risk questionnaires for POF and A-type behavior scale were filled. The risk and protective factors related to POF were analyzed after database was established via input of qualified raw data into 2007 Excel Table.Results: The incidence of POF in patients at the age of 35-40 was dramatically higher than those at the age of 17-24, 25-29 and 30-34, and there existed statistical significance (P<0.01. No significant difference was presented between two groups in terms of age of menarche, menstrual cycle, menstrual period, dysmenorrhea and active smoking (P>0.05, but there was statistical significance by comparison to gravidity, times of artificial abortion, history of mumps, history of ovarian surgery, passive smoking, physical exercise, intake of bean products, sleep quality, A-type character and self-felt much stress (P<0.05. Multi-factor Logistic regression analysis further revealed that artificial abortion, history of mumps, passive smoking, poor sleep quality and A-type character were all independent risk factors for POF (OR=5.555, 3.906, 4.031, 3.723, 5.912, and physical exercise belonged to the protective factor for POF (OR=0.102.Conclusion: Artificial abortion, history of mumps, passive smoking, poor sleep quality and A-type character pertain to risk factors for POF, and physical exercise to the protective factor for POF.

  13. In Vitro and In Vivo Effects of Tumor Suppressor Gene PTEN on Endometriosis: An Experimental Study

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    Lv, Juan; Zhu, Qiaoying; Jia, Xuemei; Yu, Ningzhu; Li, Qian

    2016-01-01

    Background Endometriosis can cause dysmenorrhea and infertility. Its pathogenesis has not yet been clarified and its treatment continues to pose enormous challenges. The protein tyrosine phosphatase (PTEN) gene is a tumor suppressor gene. The aim of this study was to investigate the role and significance of PTEN protein in the occurrence, development, and treatment of endometriosis through changes in apoptosis rate, cell cycle, and angiogenesis. Material/Methods PTEN was overexpressed and silenced in lentiviral vectors and inserted into primary endometrial cells. The changes in cell cycle and apoptosis in the different PTEN expression groups were evaluated using flow cytometry. Vessel growth mimicry was observed using 3-dimensional culture. A human-mouse chimeric endometriosis model was constructed using SCID mice. Hematoxylin and eosin staining and immunohistochemistry were used to detect pathological changes in ectopic endometrial tissues and the expression of VEGF protein in a human-mouse chimeric endometriosis mouse model. Results PTEN overexpression significantly increased apoptosis and inhibited the cell cycle compared with the silenced and control groups. Furthermore, cells expressing low PTEN levels were better able to undergo vasculogenic mimicry, and exhibited significantly increased angiogenesis compared to cells overexpressing PTEN. We found that ectopic foci were more easily formed in the endometrial tissue of SCID mice with low PTEN expression, and the VEGF expression in this group was relatively high. Conclusions PTEN inhibits the occurrence and development of endometriosis by regulating angiogenesis and the apoptosis and cell cycle of endometrial cells; therefore, we propose that the PTEN gene can be used to treat endometriosis. PMID:27744455

  14. Characteristics of the menstrual cycle in 13-year-old Flemish girls and the impact of menstrual symptoms on social life.

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    Hoppenbrouwers, Karel; Roelants, Mathieu; Meuleman, Christel; Rijkers, Anna; Van Leeuwen, Karla; Desoete, Annemie; D'Hooghe, Thomas

    2016-05-01

    This study aimed to investigate the characteristics of symptoms related to the menstrual cycle and their impact on social activities in young teenage girls. Between March and June 2009, all girls born in 1996 who were residents of eight regions in Flanders (Belgium) received a semi-structured questionnaire, including questions about the age of menarche, characteristics of the menstrual cycle, and its impact on social activities. Participants were 792 13-year-old girls (15.7 % of the target population). Out of 363 (47.2 % of participants) postmenarcheal girls, 41.6 % (95 % confidence interval (CI) 36.4-47.0 %) reported painful menstruations. The proportion of girls with painful menstrual periods decreased approximately 16 % with each year the age at menarche increased (relative risk (RR) = 0.84; 0.73-0.98; p menstrual complaints are common in young adolescent girls and the likelihood of pain increased significantly with lower menarcheal age. What is Known? • Menstrual cycle-related symptoms may negatively interfere with school absence and social activities. • Early menarche and severe dysmenorrhea are correlated with endometriosis. What is New? • In this large population-based study on the characteristics of the menstrual cycle in young teenage girls at or shortly after menarche, painful menstruation was highly prevalent (41.7 %), but related school absenteeism was low (3.2 %). The likelihood of pain increased significantly with lower menarcheal age. • The findings support the need for a systematic evaluation of the characteristics of the menstrual cycle shortly after menarche.

  15. Adolescent health problems in India: A review from 2001 to 2015

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    Punyatoya Bej

    2015-12-01

    Full Text Available Adolescence is a period in which all the habits and behaviour like high risk behaviour, substance abuse and eating habits develop that have lifelong impact. In India, programmes have been launched to address all the problems faced during adolescent period, still then adolescents are facing problems. In this review the problems faced by Indian adolescents were highlighted from the past 14 years’ studies. The studies were searched from 2001 to 2015 from Pub Med, Google scholar and other community medicine and public health related journals. The problems included were sexual health and teenage pregnancy, problems related to menstruation, illicit drugs, tobacco and alcohol use. Anaemia, eating problems, obesity, behavioural problems and oral health among adolescent were also reviewed. Nineteen abstracts and 52 full texts were available. Sexual health knowledge among adolescent varies from 41% to poor. Knowledge about sexually transmitted diseases and sexuality is less. Prevalence of dysmenorrhoea varies from 67.2% to 56.15% among adolescent girls. Prevalence of tobacco use varies from 25.1 to 12%. Prevalence of obesity varies from 3.4% to 0.35% and overweight varies from 5.5% to 5.84%. Prevalence of anaemia varies from 29% to 41.1%. Adolescents are facing depressive problems, physical fights, worry and loneliness. Prevalence of depression varies from 18.4% to 13.3%. Prevalence of dental problems varies from 18.2 to 41%. The review revealed that adolescents in India are facing problems of sexually transmitted infections, dysmenorrhea, tobacco and alcohol use, depression, physical fights, worry, loneliness and oral health problems. This needs a participation of family, community and government to resolve the issue.

  16. [Long-term use of combined hormonal contraception--myths and reality].

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    Novotná, M; Huvar, I; Bláha, O

    2002-09-01

    To assess relationship of long-term use of combined oral contraception (COC) and women health, discussion about myths connected with use of COC. Review of literature. Department of Obstetrics and Gynaecology, Hospital of Merciful Brothers, Brno, Czech Republic. Identification of studies able to address the topic using Medline database search. Besides reliable control of fertility COC protect women against dysmenorrhea, iron deficiency anemia, ovarian cysts and uterine fibroids. COC plays very important role in gynecologic endocrinology suppressing effectively hyperandrogenism, which has not only cosmetic effect but brings also improvement in cardiovascular health of affected perimenopausal women. Premenopausal using of COC could help preserve bone mineral density and can reduce the risk of developing Alzheimer's disease. The most important feature is protective effect against endometrial (by 70%) and ovarian (by 50%) cancer which increases with duration of COC use and is long lasting and may be observed 15 to 20 years after stopping use. Association of use COC with increased risk neither of cervical cancer nor breast cancer has not been confirmed. Controversy still persists over the association of long-term (longer than 8 years) COC use by young nulliparas and breast cancer. The risk in this group of users is probably slightly increased. But no authorities recommended any restriction of COC's prescription. Some studies have suggested an inverse relationship between use of COC and risk of colorectal cancer. The only established evidence of direct association between OC use and cancer risk is the increased risk for hepatocellular carcinoma in the absence of hepatitis B (but maximum by 4 cases per 1,000,000 users per year). Most non-contraceptive health benefits of COC are still not widely appreciated in spite of much evidence. The final decision of contraception method is upon well and adequate informed user by well educated doctor.

  17. The relationship between Exercise and premenstrual syndrome

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    Ameneh Safarzadeh

    2016-09-01

    Full Text Available Premenstrual syndrome (PMS starts during puberty years and it continues to the menopausal period. PMS manifests itself during every monthly luteal stage in the form of a complex of somatic, psychological and behavioral disorders. Exercises such as walking, cycling, swimming and slow running are a few suitable methods for settling down the tension and eliminating the PMS. It is evident that sport in comparison to the therapeutically drugs is free from side effects and it is devoid of any risks. Therefore, the objective of the present study is assessing the relationship between exercises and premenstrual syndrome (PMS. The present descriptive-analytical study has been conducted on 160 students of Zahedan University of Medical Sciences in 2014-2015 academic year. For gathering data a two-section questionnaire was used. The first section was related to the demographic features and the second section pertained to PSTT standard questionnaire. The questionnaires were completed in three consecutive periods of the menstrual cycle by the students based on a self-report method. Gathered data w analyzed by through SPSS 19.0. The statistical tests were used such as the descriptive statistical tests, Chi square and independent samples t-test. The participators’ average age was 21.06 ± 2.19. The subjects did exercise s ( 86 students less than twice a week, did physical activities between 2 and 4 days in a week (44 students and 30 subjects did exercises more than 4 times weekly. They had experiences of dysmenorrhea during their menstrual cycle (120 subjects. There was not observed a significant relationship between age and PMS (P>0.05. The relationship between the individuals citizenship with PMS was statistically significant (P=0.04. The relationship between sport and PMS in three measured periods was statistically significant (P<0.05. The results obtained from the present study indicated that doing regular physical exercises and continuous sport can be

  18. Sexual and Reproductive Outcomes in Early Stage Cervical Cancer Patients after Excisional Cone as a Fertility-sparing Surgery: An Italian Experience

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    Fanfani, Francesco; Landoni, Fabio; Gagliardi, Maria Lucia; Fagotti, Anna; Preti, Eleonora; Moruzzi, Maria Cristina; Monterossi, Giorgia; Scambia, Giovanni

    2014-01-01

    Background The purpose of this study was to analyze the quality of life in terms of sexual and reproductive outcome in patients suffering from early stage cervical cancer, submitted to an excisional cone as fertility-sparing treatment. Methods A multicenter retrospective analysis about specific dimensions of physical, psychological, reproductive and sexual functions after a cold-knife conization plus pelvic laparoscopic lymphadenectomy was conducted at Division of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome-Italy and at Division of Gynecology, European Institute of Oncology, Milan-Italy. The aim of this study was twofold. It aimed to analyze the quality of life in patients submitted to minimally invasive surgery and to compare these data with radical trachelectomy. Results Twenty-three patients with an average age of 30 years decided to participate in this study. After the treatment, all women (100%) had regular menstruation, 7 (30.4%) had increased not invalidating dysmenorrhea; 1 (4.4%) experienced a cervical stenosis; 6 among 10 patients that tried to conceive (60%) obtained one spontaneous pregnancy; 4 more (40%) underwent in vitro fertilization and embryo transfer and only 1 of them (25%) was successful. About sexual assessment, 1 patient (4.4%) had trouble in lubricating, 3 (13%) had anxiety about performance, 6 (26.1%) complained of dyspareunia which was resolved within 3 subsequent months. All patients (100%) obtained a complete psychological and physical recovery. Conclusion This study demonstrated preliminary encouraging data about sexual and reproductive outcome after excisional conization. A comparison with trachelectomy surely needs longer follow-ups, more cases and prospective analyses. PMID:24696793

  19. Phytotherapy and women's reproductive health: the Cameroonian perspective.

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    Njamen, Dieudonne; Mvondo, Marie Alfrede; Djiogue, Sefirin; Ketcha Wanda, Germain Jean Magloire; Magne Nde, Chantal Beatrice; Vollmer, Günter

    2013-05-01

    Approximately 80 % of the population in Africa use traditional medicinal plants to improve their state of health. The reason of such a wide use of medicinal plants has been mainly attributed to their accessibility and affordability. Expectation of little if any side effects, of a "natural" and therefore safe treatment regimen, as well as traditional beliefs additionally contribute to their popularity. Several of these plants are used by women to relieve problems related to their reproductive health, during or after their reproductive life, during pregnancy, or following parturition. The African pharmacopoeia thus provides plants used for preventing and/or treating gynecological infections, dysmenorrhea, irregular menstruations, oligomenorrhea or protracted menstruation, and infertility. Such plants may then be used as antimicrobians, emmenagogues, or as suppressors of uterine flow. African medicinal plants are also used during pregnancy for prenatal care, against fetal malposition or malpresentation, retained dead fetus, and against threatened abortion. Some others are used as anti-fertilizing drugs for birth control. Such plants may exert various activities, namely, anti-implantation or early abortifacient, anti-zygotic, blastocytotoxic, and anti-ovulatory effects. Some herbs could also act as sexual drive suppressors or as a post-coital contraceptive by reducing the fertility index. A number of these plants have already been subject to scientific investigations and many of their properties have been assessed as estrogenic, oxytocic, or anti-implantation. Taking into account the diversity of the African pharmacopoeia, we are still at an early stage in the phytochemical and pharmacological characterization of these medicinal plants that affect the female reproductive system, in order to determine, through in vitro and in vivo studies, their pharmacological properties and their active principles.

  20. The problem in the evaluation of the efficacy and safety of nonsteroidal anti-inflammatory drugs

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    N. V. Chichasova

    2016-01-01

    Full Text Available The review gives data on the safety of nimesulide used for the treatment of chronic joint diseases. The first-line treatment at its any stage for joint diseases is nonsteroidal anti-inflammatory drugs (NSAIDs. Questions have recently arisen of the safety of nimesulide; however, epidemiological findings and clinical experience confirm a positive benefit/risk profile of nimesulide in the treatment of acute pain. The International Consensus Meeting (Vienna, 2014 noted that the risk of severe adverse hepatic NSAID reactions was low and the rate of liver damage associated with nimesulide was completely similar to that observed with other NSAIDs. There are data available in the literature on the rate of serious adverse liver reactions to different NSAIDs and paracetamol. The rate of such reactions to all NSAIDs per million patientyears was 1.55 and that to nimesulide was 1.88. The members of the International Consensus Group concluded that nimesulide, if properly used, remained a valuable and safe drug for the treatment of various conditions, characterized by the presence of acute inflammatory pain, by virtue of the rapid onset of analgesic action and an evidence-based positive benefit/risk profile. The long successful experience with nimesulide in our country suggests that the agent may be successfully used to treat chronic and acute pain (including dysmenorrhea in a daily dose of 200 mg/day. The safety profile of the drug is quite satisfactorily for all adverse reactions typical of NSAIDs, including its negative effect on the liver.

  1. Preventive Adolescent Health Care in Family Practice: A Program Summary

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    Barry Knishkowy

    2006-01-01

    Full Text Available The AMA Guidelines for Adolescent Preventive Services (GAPS has been the cornerstone of preventive care for teenagers since its publication in 1994. Despite this, there has been little documentation of their implementation in the family medicine literature. This article gives an overview of a family practice–based adolescent preventive health program based on GAPS recommendations, and reports on compliance, feasibility and health issues. A Community-Oriented Primary Care (COPC program targeted all adolescent patients aged 12—18 years in two Israeli family practices. 321 teenagers were invited to participate. Every 7th and 10th grader was invited for a preventive health visit with the family physician and nurse. The visits included a medical evaluation, screening and counseling regarding health issues recommended by GAPS, and counseling regarding personal health concerns. Parents were also invited to meet with the staff. 184 (57% of the adolescents invited for health visits attended. The overall visit time was 47 minutes, including 12 minutes for a questionnaire and 35 minutes with providers. Common biomedical problems included overweight, acne and dysmenorrhea. Health risk behaviors and psychosocial problems included cigarette or alcohol use, dieting, infrequent/never seat belt use, and feeling depressed. 78% wanted to discuss at least one personal health issue. 27% were invited for follow-up visits. Only 3% of the parents came for visits. A community-oriented approach facilitates bringing adolescents for preventive health visits. Many previously undetected health issues, particularly psychosocial and behavioral, are revealed during these visits. A concerns checklist aids in addressing personal health concerns.

  2. Protective Effect of White-fleshed Peach (Prunus persica (L.) Batsch) on Chronic Nicotine-induced Toxicity

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    Kim, Hyun-Jeong; Park, Kwang-Kyun; Chung, Won-Yoon; Lee, Sun Kyoung; Kim, Ki-Rim

    2017-01-01

    Background Nicotine is a major toxic component of tobacco smoke and has been recognized as a risk factor to induce oxidative tissue damage, which is a precursor to cardiovascular diseases, lung-related diseases, and cancers. Peaches (Prunus persica) have been used for the treatment of degenerative disorders, such as hypermenorrhea, dysmenorrhea, and infertility in Asian countries. In this study, we investigated the effects of white-fleshed peach on the excretion of nicotine metabolites and 1-hydroxypyrene in smokers and chronic nicotine-induced tissue damages in mice. Methods The concentrations of cotinine and 1-hydroxypyrene were measured in urine of smokers before or after intake of white-fleshed peaches. In addition, ICR mice were injected with nicotine (5 mg/kg body weight) and then orally administered with white-fleshed peach extracts (WFPE) (250 or 500 mg/kg body weight) for 36 days. The oxidative stress parameters and the activities of antioxidant enzymes were measured in liver and kidney tissues. Also, histological changes and nitrotyrosine expression were assessed. Results Intake of white-fleshed peaches increased the urinary concentration of nicotine metabolites and 1-hydroxypyrene in 91.67% and 83.33% of smokers, respectively. WFPE decreased the malondialdehyde levels and recovered the activities of antioxidant enzymes in nicotine-injected mice. In addition, WFPE inhibited nitrotyrosine expression and inflammatory responses in the liver, kidney, and lung tissues of nicotine-treated mice. Conclusions White-fleshed peaches may increase the metabolism of toxic components in tobacco smoke in smokers and protect normal tissues against nicotine toxicity in mice. Therefore, supplementation of white-fleshed peaches might be beneficial to smokers.

  3. Research progress on contractile modulation mechanism of non-pregnant uterine%非孕期子宫收缩调控机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    罗宁; 程忠平

    2012-01-01

    Uterine contractile activity plays an important regulatory role in many aspects of women reproductive function, including transport of sperm and embryo and implantation, menstruation, gestation and parturition. Abnormal uterine contractility may lead to many common diseases such as infertility, implantation failure, dysmenorrhea, endometriosis, spontaneous miscarriage or preterm birth. So it is very important to gain a comprehensive cognition of physiological pathways that underlie the contractile activity of uterine in non-pregnant state. This review summarized an overview of contractile apparatus of uterine myocytes, physiological pathways and the molecular mechanism by which uterine contractility might be regulated, aiming to provide deeper understanding of the mechanism of uterine contractility.%子宫收缩活动参与调控女性生殖系统许多方面的功能,如精子和胚胎的转运和着床、月经、妊娠和分娩等.子宫的异常收缩可导致许多常见疾病,如不孕、受精卵植入失败、痛经、子宫内膜异位、自然流产及早产等.因此,深入地认识非孕期子宫收缩及其调节的生理机制尤为重要.该文对子宫平滑肌细胞内收缩相关的结构、功能和调节作以综述,以期加深对参与子宫收缩调控的相关分子机制的理解.

  4. Pattern of self-medication with analgesics among Iranian University students in central Iran

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    Shadi Sarahroodi

    2012-01-01

    Full Text Available Background: Self-medication is defined as the use of drugs for the treatment of self-diagnosed disorders. It is influenced by factors such as education, family, society, law, availability of drugs and exposure to advertisements. This study was performed to evaluate self-medication with analgesics and its pattern among different groups of Iranian University Students. Materials and Methods: A randomized, cross-sectional, multicenter study was conducted from December 2009 to February 2010. The target population of this study was 564 students out of 10,000 students attending four medical and non-medical science universities in Qom state. Data was analyzed using SPSS version 16, and analysis was conducted with descriptive analysis procedures. Results: 76.6% of the students had used analgesics in self-medication in the previous 3 months. The frequency of analgesic use in the study period was once in 19.2% of the participants, twice in 22.2%, three times in 16.3% and more than three times in 35.5% of the participants, although 6.8% of them were not sure when they were used. Of all the respondents, 49.8% reported headache as the problem. This was the most common problem, after which came Dysmenorrhea,headache and stomach ache. Bone and joint pains were other problems that led to the use of analgesics. The most commonly used source of information for self-medication with analgesics was advice from friends and family (54.7%, previously prescribed medications (30.1%, their medical knowledge (13.3% and recommendation of a pharmacist (1.9%. Conclusion: Self-medication with analgesics is very high among Iranian students in Qom city. This could be an index for other parts of the Iranian community. Because the source of information about analgesics is inappropriate, we would recommend education courses about analgesics and self-medication on the radio and television for the entire population.

  5. Ten-year literature review of global endometrial ablation with the NovaSure® device

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    Gimpelson RJ

    2014-03-01

    Full Text Available Richard J Gimpelson Mercy Clinic, Minimally Invasive Gynecology, Department of Obstetrics and Gynecology, Mercy Hospital St Louis, St Louis, MO, USA Abstract: This review examines the peer-reviewed literature describing prospective studies that report amenorrhea rates, patient satisfaction, and surgical reintervention rates following the NovaSure® endometrial ablation procedure. A search of the English-language literature published from 2000 to 2011 was conducted using PubMed. Ten prospective studies, six single-arm NovaSure trials, and four randomized controlled trials comparing the NovaSure procedure with other global endometrial ablation modalities met the inclusion criteria and were reviewed. The follow-up periods ranged from 6 to 60 months. Amenorrhea rates for the NovaSure procedure ranged from 30.0% to 75.0%. Patients who reported being satisfied with the NovaSure procedure ranged from 85.0% to 94.0%. In randomized controlled trials with other global endometrial ablation modalities, amenorrhea rates at 12 months with the NovaSure procedure ranged from 43.0% to 56.0%, while other modalities ranged from 8% to 24%. In addition, this manuscript reviews the following: the NovaSure technology; use of the NovaSure procedure in the office setting; intraoperative and postoperative pain; effects on premenstrual syndrome (PMS; dysmenorrhea; special circumstances, including presence of uterine disease, history of cesarean delivery, coagulopathy, or use of anticoagulant medication; post-procedure uterine cavity assessment and cancer risk; contraception and pregnancy; and safety. Keywords: abnormal uterine bleeding, menorrhagia, endometrial ablation, NovaSure®

  6. 藏红花加温胆汤对子宫内膜异位症患者外周血基质金属蛋白酶9水平的影响%Effect of Wendan Decoction plus Saffron on serum MMP-9 in endometriosis of uterus

    Institute of Scientific and Technical Information of China (English)

    杨慧君; 赵鲜

    2016-01-01

    for 24 weeks.The serum estradiol, MMP-9 and matrix metalloproteninases inhibitor-1(TIMP-1) were detected before and after treatment, the degree of pain and clinical efficacy were compared.Results Compared with before treatment, levels of estradiol(E2),progesterone(P) and luteotropic hormone(LH) decreased in two groups(P<0.01), the levels of MMP-9, MMP-9/TIMP-1 decreased(P<0.01), levels of TIMP-1 increased(P<0.01), levels of CA125 decreased(P <0.01), and the maximum diameter of pelvic mass line decreased(P<0.01), dysmenorrhea pelvic pain, dyspareunia and VAS score decreased(P<0.01).Compared with the control group, levels of E2, P and LH in the research group were lower(P<0.01), the levels of MMP-9, MMP-9/TIMP-1 were lower(P<0.01), levels of TIMP-1 were higher(P<0.01), levels of CA125 were lower(P<0.01), the maximum diameter of pelvic mass line were lower(P<0.01), dysmenorrhea and pelvic pain and VAS scores were lower(P<0.01), and the effective rate of research group was higher(P<0.05).Conclusion Wendan Decoction plus Saffron in the treatment of endometriosis of uterus was effective, and it can reduce endometriosis, dysmenorrhea and pelvic pain degree, reduce pelvic mass, and may reduce the level of serum MMP-9 related.

  7. 外来女工生殖健康主要影响因素的研究进展%Study on Influencing Factors of Reproductive Health irt Female Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    付显华; 吴兰笛; 王家骥; 朱春燕; 周志衡

    2011-01-01

    This paper describes the reproductive health status of the female migrant workers. The female migrant workers are the main group of sexually transmitted diseases. Both the prevalence of the reproductive system and the induced abortion rate among the unmarried women are high. Their subheahh rate is as high as 67.91% ,the dysmenorrhea and irregular menstruation are the principal factors which affect the subhealth of the foreign female workers. The affecting factors of reproductive health of the female migrant workers include the institutions,personal factors,environmental risk factors and occupational hazards and so on. The occupational hazards exert greater influence on the reproductive health becauise it can induce menoxenia,infertlity, spontaneous abortion and premature birth. But there are few relevant in-depth reporting in domestic news,which reflect the reality that we have confronted in preventing environmental risk factors and occupational hazards. This paper propose that the related department should make a lot of effective polices to promote the reproductive health of the female migrant workers.%本文阐述了外来女工生殖健康的现状.外来女工是性传播疾病的重点人群,她们生殖系统疾病的患病率和未婚流产率居高不下、亚健康发生率高达67.91%,导致亚健康的危险因素主要是痛经和月经不调等生殖健康问题.影响外来女工的生殖健康的危险因素主要有制度因素、个人因素、环境与职业有害因素等.其中环境与职业有害因素对女性生殖健康的影响较大,可引起月经异常、不孕、自然流产、早产等,而国内鲜见此类报道,暴露了我国防治外来女工职业危害的堪忧现状.本文建议从外来女工生殖健康的影响因素着手,采取多角度、综合干预的手段改善外来女工生殖健康,为有关部门的决策提供依据.

  8. Adolescents and oral contraceptives.

    Science.gov (United States)

    Sanfilippo, J S

    1991-01-01

    Oral contraceptive (OC) options for adolescents are provides. Clarification for those desiring a birth control method is necessary and the benefits of decreased acne and dysmenorrhea with low dose OCs should be stressed along with the importance of compliance. A community effort is suggested to communicate the sexual and contraceptive alternatives, including abstinence and outercourse (sexual stimulation to orgasm without intercourse). Attention is given to concerns associated with teenage sexual activity, prevention of adolescent pregnancy, contraceptive options for the adolescent patient, adolescent attitudes toward birth control OCs, management of the adolescent OC user, manipulation of steroid components of OCs to respond to adolescent concerns, and other hormonal contraceptive options such as minipills or abstinence. The text is supplemented with tables: the % of US women by single years of age for 1971, 1976, 1979, and 1982; comparative pregnancy and abortion rates for the US and 5 other countries; federal cost for teen childbearing; adolescent nonhormonal contraceptive methods (advantages, disadvantages, and retail cost); checklist to identify those at risk for noncompliance with OCs; hormonal side effects of OCs; risks from OCs to adolescents; and benefits of OCs. Concern about adolescent pregnancy dates back to Aristotle. A modern profile shows girls form single-parent families are sexually active at an earlier age, adolescent mothers produce offspring who repeat the cycle, victims of sexual abuse are more likely to be sexually active, and teenagers in foster care are 4 times more likely to be sexually active and 8 times more likely to become pregnant. Prevention involves a multifaceted approach. OCs are the most appropriate contraceptive choice for adolescents. Frequency of intercourse is closely associated with OC use after approximately 15 months of unprotected sexual activity. At risk for noncompliance variables are scales of personality development

  9. Evaluation of a new, low-dose levonorgestrel intrauterine contraceptive system over 5 years of use.

    Science.gov (United States)

    Gemzell-Danielsson, Kristina; Apter, Dan; Dermout, Sylvia; Faustmann, Thomas; Rosen, Kimberly; Schmelter, Thomas; Merz, Martin; Nelson, Anita

    2017-03-01

    To evaluate the efficacy and safety of a new, low-dose levonorgestrel intrauterine contraceptive system (LNG-IUS 12) for up to 5 years of use. In this Phase III study, 2885 nulliparous and parous women aged 18-35 years were randomized to LNG-IUS 8 or LNG-IUS 12 for 3 years. After 3 years, women using LNG-IUS 12 could continue for up to 2 additional years (5 years total). The primary outcome was occurrence of pregnancy (Pearl Index). Secondary outcomes included safety, bleeding, dysmenorrhea, discontinuations, and user satisfaction. From August 2007 through May 2008, out of 2885 women who were enrolled, 1453 were randomized to LNG-IUS 12. Placement was attempted in 1452/1453 (full analysis set). Mean age at baseline was 27.1 years; 39.5% were nulliparous. The cumulative 5-year Pearl Index (PI) was 0.29; the 5-year cumulative failure rate was 1.4%. The 5-year PI for ectopic pregnancy was 0.18. Over 5 years, 55.3% of women reported study drug-related treatment-emergent adverse events (TEAEs). Crude incidences of pelvic inflammatory disease, uterine perforation, and complete/partial LNG-IUS 12 expulsion were 0.6%, 0.2%, and 3.7%, respectively. Women using LNG-IUS 12 generally experienced less frequent bleeding over time. The incidence of amenorrhea during the last 90-day reference interval (end of Year 5) was 22.6%. Overall, 870 (59.9%) and 550 (37.9%) women completed 3 and 5 years of treatment, respectively; 77.8% of women who entered the extension phase completed 5 years of use. Over 5 years, 22.6% discontinued due to TEAEs, including 13 women who discontinued due to pregnancy; 76 discontinued due to bleeding problems including amenorrhea; and 163 discontinued due to desire for pregnancy, 71.2% of whom conceived within 12 months. In this study including parous and nulliparous women, LNG-IUS 12 was highly effective over 5 years of use and associated with a favorable safety profile. LNG-IUS 12 offers women a low-dose contraceptive option for up to 5 years. Copyright

  10. Intrauterine levonorgestrel delivery with frameless fibrous delivery system: review of clinical experience

    Directory of Open Access Journals (Sweden)

    Wildemeersch D

    2017-01-01

    currently existing LNG-IUSs. A frameless fibrous drug delivery system fits, in principle, in all uterine cavities and may therefore be preferable to framed drug delivery systems. This review examines the clinical performance, acceptability, and potential of the frameless LNG-IUS (FibroPlant® when used for contraception, treatment of heavy menstrual bleeding, dysmenorrhea, and endometrial suppression in women using estrogen replacement therapy, endometrial hyperplasia, and other gynecological conditions. The review concludes that FibroPlant LNG-IUS offers unique advantages in reducing side effects. Keywords: LNG-IUS, frameless, efficacy, safety, acceptability

  11. Analysis on reproductive health status and effect factors of migrant female workers in Shenzhen%深圳外来女工生殖健康状况及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    付显华; 吴兰笛; 王家骥; 朱春燕; 周志衡

    2011-01-01

    Objective: To understand the reproductive health status and effect factors of migrant female workers in Shenzhen.Methods: Stratified cluster random sampling method was used to survey the reproductive health status of 3 622 migrant female workers in Shenzhen by spot field investigation, and the results were analyzed by non- conditional logistic regression analysis.Results: The prevalence of reproductive system diseases among migrant female workers was 12.3%, the first five diseases included vaginitis ( 112 women,3.09% ), irregular menstruation ( 101 women, 2.79% ), dysmenorrhea (60 women, 1.66% ), cervicitis (74 women, 2.04% ) and pelvic inflammatory disease (38 women, 1.05% ); multivariate logistic analysis showed that the risk factors of reproductive system diseases included history of induced abortion, having sexual behavior in recent three months, working more than 2 years and older age.Conclusion: The prevalence of reproductive system diseases among migrant female workers is high, it is urgent to provide effective reproductive health education and services for them.%目的:了解深圳外来女工的生殖健康状况及其影响因素.方法:采用随机分层整群抽样方法对3 622名深圳外来女工进行生殖健康相关问题的现场问卷调查,对调查数据进行非条件Logistic回归分析.结果:外来女工生殖系统疾病患病率12.3%,前5名疾病分别是阴道炎(112人,3.09%)、月经不调(101人,2.79%)、痛经(60人,1.66%)、宫颈炎(74人,2.04%)、盆腔炎(38人,1.05%);多因素分析显示有人工流产史、近3个月有性行为、工作时间大于2年、年龄大是生殖健康疾病患病的危险因素.结论:外来女工的生殖系统疾病患病率高,为她们提供有效地生殖健康教育和服务刻不容缓.

  12. Burden of menstrual symptoms in Japanese women – an analysis of medical care-seeking behavior from a survey-based study

    Directory of Open Access Journals (Sweden)

    Tanaka E

    2013-12-01

    Full Text Available Erika Tanaka,1 Mikio Momoeda,2 Yutaka Osuga,3 Bruno Rossi,4 Ken Nomoto,5 Masakane Hayakawa,5 Kinya Kokubo,6 Edward CY Wang1 1Health Economics and Outcomes Research, Bayer Yakuhin Ltd, Tokyo, Japan; 2Department of Integrated Women's Health, St Luke's International Hospital, Tokyo, Japan; 3Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan; 4Market Access, Bayer Yakuhin Ltd, Osaka, Japan; 5Medical Affairs Women's Health and Dermatology, Bayer Yakuhin Ltd, Osaka, Japan; 6Consumer Goods/Service and Healthcare Industry Consulting Department, Nomura Research Institute, Tokyo, Japan Background: Menstrual symptoms are associated with various health problems in women of reproductive age, and this may impact their quality of life. Despite this, Japanese women are likely to hesitate seeking a specialist's medical help for their menstrual symptoms. Purpose: To study subject parameters including symptom severity, gynecological disorders, and treatments in medical care-seeking women (outpatient and women opting for self-care (nonvisit, to identify reasons why Japanese women do not see a gynecologist, and to document the benefit of gynecologist visits by assessing the impact on women's daily lives. Methods: Two online surveys were conducted among women aged 15–49 years. Sampling was structured to approximate the age and geographic distribution in Japan. Results of the first survey and part of the second survey on the overall current burden of menstrual symptoms are reported in a separate publication. Further outcomes from the second survey reported in this paper included data from the outpatient (n=274 and nonvisit (n=500 groups on symptom severity, gynecological disorders, medical treatment use, reasons for not seeking medical care, and the improvement of daily life. Results: The outpatient group tended to have greater symptom severity compared to the nonvisit group. Uterine fibroids, dysmenorrhea

  13. [Changes of menstruation patterns and adverse effects during the treatment of LNG-IUS for symptomatic adenomyosis].

    Science.gov (United States)

    Li, L; Leng, J H; Zhang, J J; Jia, S Z; Li, X Y; Shi, J H; Dai, Y; Zhang, J R; Li, T; Xu, X X; Liu, Z Z; You, S S; Chang, X Y; Lang, J H

    2016-09-25

    Objective: To investigate the changes of mestruation patterns and adverse effects during the treatment of levonorgestrel-releasing intrauterine system(LNG-IUS)for symptomatic adenomyosis in a prospective cohort study. Methods: From December, 2006 to December, 2014, patients of symptomatic adenomyosis diagnosed by transvaginal ultrasound in Peking Union Medical College Hospital were given LNG-IUS. Before and after placement of IUS, all patients' parameters were recorded, including carrying status of IUS, symptoms and scores of dysmenorrhea, menstruation scores, biochemical indicators, physical parameters, menstruation patterns and adverse effects. Risk factors for changes of menstruation patterns and adverse effects, and their impact on treatment effects were analyzed. Results: Totally 1 100 cases met inclusion criteria, with median age 36 years(range 20-44 years), median follow-up 35 months(range 1 -108 months). During follow-up changes of menstruation patterns increased significantly with amenorrhea and shortened-menstruation being the most common manifestations. On 3, 6, 12, 24, 36, 48 and 60 months after the placement of LNG-IUS, 0, 5.8%(43/744), 6.9%(47/682), 10.1%(60/595), 17.3%(87/502), 27.2%(104/383)and 29.6%(82/277)patients achieved amenorrhea respectively(P12 months after placement, abdominal pain and body weight increasing ≥5 kg/year were the most common adverse effects. Changes of menstruation patterns, total and subclassifications of adverse effects were neither dependent on patient parameters, treatment modes and treatment effects, nor could predict future LNG-IUS carrying status(all P> 0.05). After taking out of LNG-IUS, most changes of menstruation and adverse effects disappeared. Conclusions: During the treatment of LNG-IUS for symptomatic adenomyosis, changes of menstruation patterns increase gradually with amenorrhea and shortened-menstruation being the most common manifestations, while adverse effects decrease significantly. Changes of

  14. Endometriose de septo retovaginal: doença de diagnóstico e tratamento específicos Rectovaginal septum endometriosis: a disease with specific diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Mauricio Simões Abrão

    2003-09-01

    Full Text Available RACIONAL: O envolvimento do septo retovaginal, reto e sigmóide pela endometriose pode causar sintomas intensos como dismenorréia, dor pélvica, dispareunia de profundidade, tenesmo e proctorragia cíclicos, em mulheres em idade reprodutiva. O diagnóstico pode ser suspeitado diante da história clínica típica e exame ginecológico adequado, ou ainda através de exame retal, enema opaco ou colonoscopia, entre outros. As indicações cirúrgicas, em geral, estão relacionadas à intensidade dos sintomas e falha no tratamento conservador. No entanto, o tratamento de escolha, para este tipo de endometriose, é a ressecção cirúrgica do tecido acometido, a fim de aliviar os sintomas e evitar progressão da doença. A localização correta assim como a avaliação da presença de extensão do processo em direção ao reto, ligamentos uterossacros ou septo retovaginal é extremamente importante para se garantir um tratamento cirúrgico eficaz. OBJETIVO: Descrever os principais aspectos relacionados à endometriose de septo retovaginal e fornecer aos cirurgiões gerais algumas informações específicas sobre esta enigmática doença. CONCLUSÃO: A endometriose de septo retovaginal é doença freqüente, de diagnóstico e tratamento específicos.BACKGROUND: The involvement of the rectovaginal septum, of rectum and sigmoid by endometriosis leads to intense symptoms as dysmenorrhea, pelvic pain, deep dyspareunia, tenesmus and hematochezia in young and middle aged women during periods. The diagnosis can be made by tipycal history and vaginal examination, rectal examination, barium enema, proctoscopy and so on. The indications of operation include severe clinic symptoms and failed conservative therapy. The treatment of choice for this type of endometriosis is the surgical resection of affected tissue, in order to relieve patient symptoms, and avoid disease progression. The correct assessment as to the presence and extension of the endometriosis

  15. Ressonância magnética na endometriose pélvica profunda: ensaio iconográfico Magnetic resonance imaging in deep pelvic endometriosis: iconographic essay

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Coutinho Junior

    2008-04-01

    Full Text Available A endometriose caracteriza-se pela presença de tecido endometrial funcionante heterotópico. Em pacientes com endometriose pélvica profunda pode haver acometimento dos ligamentos útero-sacros, reto, septo retovaginal, vagina ou bexiga. Os sintomas podem ser variados e incluem dor pélvica, dismenorréia, dispareunia, sintomas urinários e infertilidade. O padrão-ouro para o tratamento é a ressecção completa dessas lesões. Assim, é muito importante a avaliação pré-operatória dessas pacientes, sendo esta avaliação, em geral, limitada em relação aos dados clínicos e ultra-sonográficos. A ressonância magnética tem grande importância no diagnóstico da endometriose, principalmente por permitir a identificação das lesões de permeio a aderências e a avaliação da extensão das lesões subperitoneais. Neste estudo são ilustrados, na forma de ensaio iconográfico, os principais achados da endometriose pélvica profunda à ressonância magnética.Endometriosis is characterized by the presence of normal endometrial tissue outside the uterine cavity. In patients with deep pelvic endometriosis, uterosacral ligaments, rectum, rectovaginal septum, vagina or bladder may be involved. Clinical manifestations may be variable, including pelvic pain, dysmenorrhea, dyspareunia, urinary symptoms and infertility. Complete surgical excision is the gold standard for treating this disease, and hence the importance of the preoperative work-up that usually is limited to an evaluation of sonographic and clinical data. Magnetic resonance imaging is of paramount importance in the diagnosis of endometriosis, considering its high accuracy in the identification of lesions intermingled with adhesions, and in the determination of peritoneal lesions extent. The present pictorial review describes the main magnetic resonance imaging findings in deep pelvic endometriosis.

  16. Microbial and cytopathological study of intrauterine contraceptive device users

    Directory of Open Access Journals (Sweden)

    Agarwal Krishna

    2004-09-01

    Full Text Available CONTEXT: Intrauterine contraceptive device (IUCD is a commonly used birth-spacing method which is fitted into maternal system. Clinical, microbial and cytopathological monitoring of women using these devices are important for ascertaining their side effects, risk of genital tract infection and carcinogenic potential. AIMS: To study clinical, microbial and cytopathological changes in IUCD users in a tertiary care hospital. DESIGN: Prospective analytic. SETTING: Tertiary hospital. MATERIAL AND METHODS: women visiting Family Planning clinic for follow up (IUCD users, n=100 or for IUCD insertion (controls, n=50 were enrolled in the study. Each subject underwent detailed history, general physical, systemic, and per local examination. Vaginal discharge was subjected to pH testing, KOH and wet mount examination, gram staining, and for culture and sensitivity. Bacterial vaginosis was defined using Nugent criteria. Cervical smears were examined and reported as per Bethesda system. STATISTICAL ANALYSIS: The information was entered into Microsoft Excel spreadsheet. The results were analyzed using EPI Info version-6 and Stata statistical software version 7 packages. Two-tailed t-test, chi2 test with Yates correction and two-tailed Fisher Exact tests were applied. RESULTS: Most women used CuT 200 (92%. Median duration of use was 2 years. Chief complaints of IUCD users included backache (54%, vaginal discharge (46%, pain lower abdomen (34%, dyspareunia (22%, menorrhagia (18% and dysmenorrhea (14%. Mean hemoglobin was lower in IUCD users than controls (11.2±1.7 versus 11.9±1.8 g/dL, p 0.02. Proportion of women with anemia was higher in IUCD users than in controls (29% versus 16%, p 0.12. Cervical erosion was significantly increased in study group as compared the controls (20% versus 0%, p=0.00 whereas only insignificant increase in vaginitis (6% versus 0%, p=0.17. Trichomonas vaginalis and fungal hyphae positivity and gram stain findings and bacterial

  17. Adolescent reproductive health challenges among schoolgirls in southeast Nigeria: role of knowledge of menstrual pattern and contraceptive adherence

    Directory of Open Access Journals (Sweden)

    Ajah LO

    2015-08-01

    Full Text Available Leonard Ogbonna Ajah,1 Ebele Samuel Onubogu,1 Okechukwu Bonaventure Anozie,1 Lucky Osaheni Lawani,1 Chukwuemeka Anthony Iyoke,2 Emeka Ogah Onwe,3 Monique Iheoma Ajah4 1Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, 2Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, 3Department of Paediatrics, 4Well Women Centre, Federal Teaching Hospital, Abakaliki, Nigeria Background: Reproductive health services in the form of adolescent health and contraceptive services are fundamental in the prevention of a high incidence of teenage pregnancy. The purpose of this study was to determine the age at menarche, menstrual pattern, and awareness of and use of modern contraception among secondary school girls in Abakaliki, Nigeria.Subjects and materials: This was a cross-sectional study in which self-administered questionnaires were completed by 482 adolescent girls at two girls’ secondary schools between August and September 2012.Results: The mean age at menarche was 13.13±1.37 years. The mean menstrual cycle length was 27.8±3.14 days, and the mean duration of menstrual flow was 4.8±1.14 days. Thirty-seven (7.7% respondents were ignorant of their cycle length, while 29 (6.0% had irregular cycles. Premenstrual syndrome and dysmenorrhea were major menstrual issues, which resulted in 69 (14.3% and 59 (12.2% of respondents resorting to self-medication and absenteeism from school, respectively. Mothers were the main source of their daughters’ adolescent education, while friends and mass media were the main source of contraceptive information. Though there was a high level (75.7% of awareness of contraceptive information among the girls, usage (8.9% was poor. Only eight (18.6% of the 43 respondents who had ever used modern contraception were adherent to modern contraceptives. Students who were more than 15 years old, attained menarche at 13 years or less, and whose families were of

  18. Summary of clinic application of Xiaoyao Powder in recent ten years%逍遥散近十年的临床应用概述

    Institute of Scientific and Technical Information of China (English)

    郭艳苓

    2013-01-01

    逍遥散为调和肝脾的常用代表方剂,具有疏肝解郁、健脾和营、养血调经之功.笔者总结近十年逍遥散临床应用概况,在妇科领域有痛经、月经不调、经前期紧张综合征、乳腺病、不孕症、更年期综合征等,消化系统疾病如肠易激综合症、功能性消化不良等,内分泌系统疾病如高催乳素血症、糖尿病、甲亢性心脏病等,神经系统疾病如神经衰弱、失眠等,皮肤科的黄褐斑、痤疮等都有应用.只要辨证准确,谨守病机,都取得了理想的治疗效果,充分体现了中医异病同治的治则精髓.%Xiaoyao Powder is a representative prescription for relieving Qi stagnancy, tonifying spleen and reconciling Ying, nourishing blood for regulating tnenstruation. The author has made a summary oi the clinie application of Xiaoyao Powder in recent ten years. Fust, it is used in gynaecology for dysmen-orrhea, irregular tnenstrnation, premenstrual tension syndrome, mastosis, infertility, menopause syndrome. Second, it is suitable for irritable bowel syndrome, funrtional dyspepsia in digestive system. Third, it is suitable for hyperprolactinemia, diabetes, hyperthyroid heart disease in endocrine system. Four, it is suitable for neurosism, insomnia in nervous system. Five, it is also suitable for chloasma, acne in dermatology. This prescription has achieved a lot on the basis of accurate differentiation and cautiously grasping pathogenesis, all of which embodies the core of rules of treatment, namely , homotherapy for heter-opathy.

  19. Síndrome pós-laqueadura: repercussões clínicas e psíquicas da pós-laqueadura Post-tubal sterilization syndrome: evaluation of the psychological and clinical disturbances in tubal ligation syndrome

    Directory of Open Access Journals (Sweden)

    Rogério Dias

    1998-05-01

    Full Text Available O objetivo deste estudo foi investigar as alterações menstruais e os efeitos psíquicos decorrentes da laqueadura tubária - síndrome pós-laqueadura. Os autores acompanharam prospectivamente 300 mulheres do Setor de Endoscopia Ginecológica e Planejamento Familiar do Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP, durante um, três e cinco anos após o procedimento cirúrgico de laqueadura. Diferentes parâmetros foram analisados após a laqueadura, tais como: intervalo do ciclo menstrual, duração e intensidade do fluxo menstrual, dismenorréia, dor pélvica, taxa de arrependimento e outros, comparando-se com os padrões prévios ao procedimento. Nossos achados sugerem que a maioria das mulheres estudadas não apresentaram alterações pós-laqueadura. Tais achados não negam ou diminuem a importância e os benefícios da esterilização tubária, mas servem como ponto de partida para futuras investigações.The purpose of the present study was to investigate the menstrual disturbances and the psychological effects of post-tubal sterilization - the so-called post-tubal sterilization syndrome. Does it exist? The authors followed-up prospectively 300 women from the Gynecological Endoscopy and Family Planning Section, Department of Obstetrics and Gynecology, Botucatu Medical School, Universidade Estadual Paulista (UNESP during one, three and five years after tubal sterilization surgery. Different parameters such as menstrual cycle length, duration of menstrual flow, dysmenorrhea, pelvic pain, regret rates etc, after tubal ligation, were analyzed. Each woman served as her own control. In conclusion, our findings suggest that most women reported no menstrual changes subsequent to sterilization. These findings do not deny or diminish the importance or benefits of tubal sterilization, but serve as a focus for further investigation.

  20. The postal tubal ligation syndrome.

    Science.gov (United States)

    Faber, E; Rocko, J M; Timmes, J J; Zolli, A F

    1981-01-01

    The frequency of symptoms following tubal ligation calls for an examination of the basic problem with the methods now used. This discussion recommends a modification of tubal ligation which as performed during the past 2-1/2 years has been symptom free, post operatively. What is meant by symptom free is those symptoms which can be directly related to tubal ligation. Symptomatology is complex and insidious. Characteristically, there is a latent period of no symptoms. This asymptomatic period may be totally subjective and may last several years during which time the correlation between surgery and symptoms is obscured. This is particularly the case if purely symptomatic therapeusis has had some degree of success. The latest period is followed by the gradual development of the following: menstrual disorders; abdominal pain which is usually located in the lower abdomen and is of 2 varieties, i.e., dysmenorrhea and nonmenstrual pain; and infection. Physical examination demonstrates little. This set of symptoms, which has been documented also by Poma et al., and when taken as a whole, constitutes a syndrome which should be termed the posttubal ligation syndrome. These patients give a history of repeat X-rays, biopsies, endoscopies, and surgical exploration. Some of these patients have had 4 or 5 celiotomies. A modification of the traditional method of tubal ligation definitely requires consideration. The characteristics of the oviducts which need mention and emphasis are reviewed. On the basis of the reviewed considerations, it becomes obvious that smooth transport of the ovum is a necessity and that obstruction in the tubes will cause a reaction similar to obstruction anywhere in the body. Tubal ligation should be performed in such a manner so as not to obstruct the ova from passing down the tube. The tubes should be cut fairly close to the uterus and be tied. The rest of the tube from fimbria to the isthmus should be left open. In this manner, the ovum passes into the

  1. 子宫内膜异位症发病的研究探讨

    Institute of Scientific and Technical Information of China (English)

    于博

    2014-01-01

    目的:探讨分析与子宫内膜异位症发病相关的因素,为预防子宫内膜异位提供科学的依据。方法采用病例对照研究中的成组设计的方法,从我院选择100例子宫内膜异位症患者作为病例组,另外选择100例非子宫内膜异位症患者作为对照组,分别调查两组患者的个人习惯、月经史和生育史,进行相关分析,从而筛选出子宫内膜异位症发病的危险因素。结果与子宫内膜异位症发病相关的因素有痛经、经量过大、经期参加体育运动、喜欢穿紧身衣裤、IgA水平升高等。结论子宫内膜异位症的发病与个人的生活习惯、月经史以及免疫功能等因素显著相关。%Objective:To study the risk factors associated with endometriosis in o rder to find possible ways to prevent endometriosis. Methods:In a case control study,100 women with endometriosis and 100 with non-endometriosis diseases were included.The investigation included:personal habits,menstrua l histories,pregnancy histories and so on.Results:Single factor analysis indicated the risk factors related to endometriosis were dysmenorrhea,menorrhagia,wearing tight und erclothes,taking exercise in menstrual period and high IgA level.There were significant difference (P<0.05) between two groups.Conclusion:The study suggested that the re were correlations between endometriosis and personal habits,menstrual histories and mimune function.

  2. Mirena Treatment of Adenomyosis Evaluation and Analysis of Adverse Reactions%曼月乐治疗子宫腺肌病的效果评价及不良反应探析

    Institute of Scientific and Technical Information of China (English)

    李秀红

    2014-01-01

    Objective The effects of Mirena adenomyosis treatment,and adverse reactions are discussed.Methods 50 cases of uterine adenomyosis patients admitted to our hospital for the object,randomized control group,the main use of methyltestosterone tablets for treatment in the experimental group were treated using Mirena.Two groups of patients for clinical efficacy were observed and compared.Results The patients in the experimental group menstrual flow after treatment was significantly less than the control group,dysmenorrhea score lower than the control group,uterine volume less than the control group,the differences are significant,statistically significant(P<0.05).Adverse reactions include controls acne,hirsutism,changes in libido and sound thicker,the experimental group adverse reactions include vaginal spotting,ring off,breast tenderness,and amenorrhea.Conclusion Mirena adenomyosis treatment,safe and reliable,worthy of popularization and application.%目的:对曼月乐治疗子宫腺肌病的效果以及不良反应进行探讨。方法选取我院收治的50例子宫腺肌病患者为对象,随机分组,对照组主要采用甲睾酮片进行治疗,实验组采用曼月乐进行治疗。对两组患者的临床疗效进行观察和比较。结果实验组患者治疗后的月经量明显比对照组少,痛经评分比对照组低,子宫体积比对照组小,差异明显,有统计学意义(P<0.05)。对照组不良反应包括痤疮、多毛、性欲改变以及声音变粗,实验组不良反应包括阴道点滴出血、环脱落、乳房胀痛以及闭经。结论采用曼月乐对子宫腺肌病进行治疗,安全可靠,值得普及和应用。

  3. SAFETY AND TOLERABILITY OF ANTIEPILEPTIC DRUGS AT WOMEN WITH EPILEPSY (DATA OF SVT. LUKA’S INSTITUTE OF CHILD NEUROLOGY AND EPILEPSY

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    K. Yu. Мukhin

    2015-01-01

    Full Text Available Women with epilepsy are referred to the special risk group due to the development of side effects of antiepileptic drugs (АED. Women’s neuroendocrinal disorders can be caused by the disease itself-epilepsy, as well as by the undertaken therapy. We have carried out a retrospective research in order to assess the safety and the tolerance of different AED at young girls and women of reproductive age. Was analyzed the data base of patients of Svt. Luka’s Institute of Child Neurology and Epilepsy, comprising all patients, who have been monitored in the period between 2000 and 2014 inclusive at the age between 15–40 years (n = 301. The research included patients, with different diagnosed forms of focal or generalized epilepsy, who were taking AED both during mono and polytherapy. Were analyzed all cases of neuroendocrinal, especially reproductive disorders, including the considerable gain of weight, menstrual disorder, sterility at AED background. Also was analyzed the result of all registered pregnancies at women with epilepsy (at the background of the antiepileptic therapy, as well as without treatment during pregnancy. The retrospective data analysis has revealed 51 сase (17 % in the group under review of expressed neuroendocrinal, reproductive and cosmetic side effects (including the menstrual disorder: dysmenorrhea, opsomenorrhea, amenorrhea, anovulatory cycles, sterility, unfavorable pregnancy outcomes, as well as cosmetic endocrinal side effects: obesity, hirsutism, hair loss. Most patients have got such combined side effects. Our research results show, that in most cases the pregnancy at women with epilepsy ends by birth of a healthy child, the pregnancy outcome depends on many factors, it also differs according to applied AED. Valproic acid drugs show the highest teratogenic risk. Also at the back ground of the therapy with valproic acid have been registered most cases of neuroendocrinal reproductive diseases at women

  4. Improvement of the liver pathology by the aqueous extract and the n-butanol fraction of Sida pilosa Retz in Schistosoma mansoni-infected mice.

    Science.gov (United States)

    Jatsa, Hermine Boukeng; Russo, Remo Castro; Pereira, Cintia Aparecida de Jesus; Aguilar, Edenil Costa; Garcia, Cristiana Couto; Araújo, Emília Souza; Oliveira, Jailza Lima Rodrigues; Rodrigues, Vanessa Fernandes; de Oliveira, Vinícius Gustavo; Alvarez-Leite, Jacqueline Isaura; Braga, Fernão Castro; Louis-Albert Tchuem Tchuente; Kamtchouing, Pierre; Negrão-Corrêa, Deborah Aparecida; Teixeira, Mauro Martins

    2016-03-02

    Sida pilosa Retz (Malvaceae) is a plant used in Africa for the treatment of intestinal helminthiasis, lower abdominal pains and dysmenorrhea. In order to determine the potential use of S. pilosa in the treatment of schistosomiasis mansoni, we evaluated the schistosomicidal, antioxidant and anti-fibrotic properties of the aqueous extract and the n-butanol fraction of its aerial parts. S. pilosa aqueous extract (SpAE) at 100, 200 and 400mg/kg and n-butanol fraction (SpBF) at 50, 100 and 200mg/kg were administered per os to Schistosoma mansoni-infected mice for 4 weeks. Praziquantel (100mg/kg × 5 days) was used as reference drug. After sacrifice, worm burden and egg count, transaminases and proteins levels were evaluated. Malondialdehyde (MDA), lipid hydroperoxydes (LOOH), catalase (CAT), superoxide dismutase (SOD), eosinophil peroxidase (EPO) and myeloperoxidase (MPO) were also measured. The anti-fibrotic effect of the plant was evaluated by the determination of hydroxyproline and γ-interferon (IFN-γ). The treatment of S. mansoni-infected mice by SpAE or SpBF resulted in a moderate reduction of worm burden and egg load in the liver and intestine. Both SpAE and SpBF significantly reversed the increasing liver proteins, MDA, LOOH and CAT levels induced by the infection. Moreover, SOD activity was improved by SpAE and SpBF. Schistosomiasis mansoni considerably increased the EPO (p<0.001) and MPO activities (p<0.001). SpAE treatment significantly reduced EPO and MPO activities at all doses. SpBF failed to reduce the increasing MPO and decreased EPO only at the highest dose. S. mansoni-infection induced an increase in hydroxyproline content (p<0.001) and a decrease in IFN-γ level (p<0.001). Both SpAE and SpBF significantly reduced hepatic hydroxyproline content, while only SpAE (p<0.05) improved IFN-γ level. These results suggest that the liver pathology in schistosomiasis mansoni is improved by S. pilosa aqueous extract, which disclosed a moderate schistosomicidal

  5. [Gyneco-obstetrical morbidity in the population of Santiago].

    Science.gov (United States)

    Salinas, H; Kaempffer, A M; Walton, R; Bocaz, J; Hernández, E; Ramírez, R; Villaroel, R; Báez, M; Carmona, M; Castillo, P

    1988-01-01

    1607 women were interviewed about their gyneco-obstetrical health in a survey of 469 randomly selected households in the province of Santiago, Chile. The dependent variables correspond to the frequency of gynecologic or obstetrical morbidity and demand for medical attention in 2 weeks of April, 1987. Independent variables were age, educational status, and health insurance coverage. 125 of the households were headed by uninsured persons. The average woman was 34.4 years old. 43.1% had 8 years or less of education, 42.6% had 9.12 years, and 14.2% had 13 or more years. 21 new cases of acute obstetrical or gynecological disorders were reported, including 15 of vulvovaginitis, 3 abortions, 1 bartholinitis, 1 intrahepatic cholestasis of pregnancy, and 1 urinary tract infection. There were 55 cases of chronic disorders, including 12 benign ovarian lesions, 8 dysmenorrheas, 8 uterine dystropias, 10 cases of menstrual disturbances, 1 of infertility, 4 benign cervical lesions, 5 benign uterine lesions, 2 pelvic inflammations, 2 cervical cancers, 2 breast cancers, and 1 ovarian cancer. Among the 1607 women, 11 had consulted for family planning in the 2 weeks, 25 for pregnancy, 22 for gynecological conditions, and 9 for postpartum care. 58.3% of the women aged 15-49 used a contraceptive method. The proportions of users of oral contraceptives and IUDs respectively were 62.5% and 37.5% for women under 20, 60% and 40% for women 20-29, 27% and 61% for women 30-39, and 15.1% and 60.6% for women 40-49. 28.2% of women over 15 had had a Pap test in the past year. The proportions of different age groups having Pap tests ranged from 2.0% for women under 20 to 46.7% for women aged 30-39. 3 women in the sample households had died in the past year of gyneco-obstetric causes, 1 of complications of childbirth and 2 of cervical cancer.

  6. Valdecoxib (Pharmacia).

    Science.gov (United States)

    Gotta, Alexander W

    2002-02-01

    Pharmacia (formerly Searle), in collaboration with Pfizer and Yamanouchi, has developed valdecoxib, a second-generation cyclooxygenase (COX)-2 inhibitor as a follow-up to celecoxib, for the treatment of arthritis. Pharmacia filed an NDA with the FDA in March 2001 for the treatment of acute pain, dysmenorrhea, osteoarthritis (OA) and rheumatoid arthritis (RA). At this time, Pharmacia anticipated a 12-month review [402883]. In June 2001, launch was anticipated in 2002 [412616], and in November 2001, valdecoxib was granted FDA approval [429715]. The company claims that valdecoxib has improved potency and broader therapeutic range than other COX-2 inhibitors including celecoxib, and has the potential for once-daily dosing [287279], [313957]. By 1999, due to the poor water solubility of valdecoxib, Searle was also developing the prodrug parecoxib [324667]. Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667]. In April 2000, Morgan Stanley Dean Witter estimated sales would be US $400 million in 2003, rising to US $750 million in 2004 [375906]. In April 2001, Merrill Lynch predicted world sales of US $460 million in 2002, rising to $1,065 million in 2005 [420574]. In September 2000, Merrill Lynch reported that additional pain data were being accumulated for this drug, the possible inclusion of which could push filing back to later in the first half of 2001 [382577]. In May 2001, Merrill Lynch expected launch in 2002 [411811]. In August 2001, Lehman Brothers predicted that launch would take place in thefirst half of 2002 and the product would make peak sales of US $1,500 million [420809]. Credit Suisse predicted in this month that total sales would reach US $330 million in 2002, rising to US $1832 million in 2004 [422318]. In September 2001, Morgan Stanley expected launch in the first half of 2002 [427113]. By October

  7. 腹腔镜与经腹卵巢巧克力囊肿剥除术后的临床疗效分析%Clinical Curative Effect Analysis of Laparoscopic Ovarian Chocolate Cyst Removed and Abdominal Postoperative

    Institute of Scientific and Technical Information of China (English)

    张翠娟; 林金凤; 李济衡

    2013-01-01

      目的比较腹腔镜与传统开腹手术初次卵巢巧克力囊肿剥除术后的临床疗效。方法回顾性分析及追踪回访我院近10年来60例行开腹手术与60例腹腔镜手术患者的临床与随访资料,观察和比较术后是否复发,以及术后痛经的程度的改善和术后卵巢功能的恢复及术后妊娠率。结果两组患者均顺利完成手术,无术中术后并发症。手术时间60~135min。术后平均住院天数4.52d。结论腹腔镜手术优于传统开腹手术,不会增加复发的风险。同时,腹腔镜作为微创手术,具有创伤小,同时又放大作用,可观察整个盆腹腔以及微小的异位病症,手术彻底,恢复时间短等优点,值得临床广泛推广和应用。%  Objective Comparison of laparoscopy and traditional laparotomy in initial clinical effect of postoperative ovarian chocolate cyst removed. Methods Retrospective analysis and tracing visit our Institute over the past 10 years 60 routine laparotomy and 60 cases of laparoscopic surgery in patients with clinical and follow-up of information, observation and comparison of postoperative recurrence and postoperative degrees of improvement of dysmenorrhea and ovarian function recovery after operation and postoperative pregnancy rate. Result Two groups of patients were successfully operated, no postoperative complications. Operative time was 60 to 135min. The mean postoperative hospital stay days 4.52d. Conclusions Laparoscopic surgery than traditional open surgery, does not increase the risk of recurrence. At the same time, as a minimally invasive laparoscopic surgery, with small wounds, while zoom in, and observe the entire ectopic symptoms of abdominal and small, operative completely, recovery time is short, and other advantages, is widely promoted and clinical applications.

  8. Aspectos epidemiológicos e clínicos da endometriose pélvica: uma série de casos Epidemiological and clinical aspects of pelvic endometriosis: series of cases

    Directory of Open Access Journals (Sweden)

    Patrick Bellelis

    2010-01-01

    Full Text Available OBJETIVO: Descrever aspectos clínicos e epidemiológicos das pacientes portadoras de endometriose pélvica operadas em nosso serviço. MÉTODOS: Estudo retrospectivo de 892 pacientes submetidas a videolaparoscopia com confirmação histológica do diagnóstico de endometriose. RESULTADOS: A média de idade foi de 33,2 ± 6,3 anos, sendo 78,7% brancas. Observamos 76,9% de mulheres com 2º ou 3º graus completos; 56,5% das pacientes eram nulíparas e 62,2% relataram dismenorreia como principal queixa. A dor pélvica crônica foi o sintoma mais prevalente, seguido pela dispareunia de profundidade, sendo referidos por 56,8% e 54,7% das pacientes, respectivamente. A infertilidade foi referida por 39,8% das 892 pacientes. CONCLUSÃO: A endometriose é uma doença geralmente diagnosticada na 4º década da vida das pacientes, as quais apresentam queixas clínicas relacionadas com frequência à dor pélvica e infertilidade, que devem sempre ser questionadas para orientar a hipótese diagnóstica.OBJECTIVE: To describe clinical and epidemiological aspects of patients with pelvic endometriosis who were operated in our service. METHODS: A retrospective study was made of 892 patients submitted to laparoscopy with histological confirmation of diagnosis of endometriosis. RESULTS: The mean age was 33.2 ± 6.3 years and 78.7% were Caucasian. We found that 76.9% of women had higher education. 56.5% of patients were nulliparous and 62.2% reported dysmenorrhea as the main complaint. Chronic pelvic pain was the most prevalent symptom, followed by deep dyspareunia, mentioned by 56.8% and 54.7% of patients, respectively. Infertility was reported by 39.8% of the 892 patients. CONCLUSION: Endometriosis is a disease diagnosed in the 4th decade of life, of patients who have multiple complaints . They must always be questioned to properly orient diagnosis and monitor results of treatment.

  9. Drospirenone detected in postmortem blood of a young woman with pulmonary thromboembolism: A case report and review of the literature.

    Science.gov (United States)

    Idota, Nozomi; Kobayashi, Masaki; Miyamori, Daisuke; Kakiuchi, Yasuhiro; Ikegaya, Hiroshi

    2015-03-01

    Progestin/estrogen oral contraceptives have some side effects, including venous thromboembolism. To alleviate side effects, improvements have been made to low-dose oral contraceptives, including reductions in the amount of estrogen and/or changes the type of progestin. A compound drug containing 3mg drospirenone and 20μg ethinylestradiol (DRSP/EE20, YAZ®) was released in overseas markets in 2006, and in Japan in 2010 as a newly developed low-dose medicines. This drug is expected to have lower side effects. We received a medicolegal autopsy case of a young woman who had been prescribed YAZ for dysmenorrhea for 17months. The autopsy revealed a blood clot in her pulmonary artery bifurcation. Blood screening by ultra-performance liquid chromatography-mass spectrometry analysis did not detect any medicinal toxicants. However, from police investigations, it is strongly believed that she had been taking YAZ. Therefore we performed a single ion resolution mode assay and detected DRSP. A quantitative analysis revealed 32.3ng/mL of DRSP. As no other cause of the pulmonary thromboembolism was evident, we consider YAZ as the likely cause of the pulmonary thromboembolism. Recent reports from the past few years suggest a higher risk of venous thromboembolism with DRSP/EE20 than earlier progestin/estrogen oral contraceptives. Comparing the risk associated with DRSP/EE20 and DRSP/EE30, one report found no differences and another report showed DRSP/EE20 was associated with a higher risk than DRSP/EE30. No cases of thrombosis caused by progestin alone have been reported. But comparing the risk between DRSP/EE20 and other progestins/EE20, two studies reported DRSP/EE20 had a higher risk than other progestins/EE20. The incidence of venous thromboembolism is highest in the first year of use and decreases thereafter. Because DRSP/EE20 has been on the market for only a couple of years, it is necessary for clinicians to use the drug carefully and accumulate more side-effect data. It is

  10. Antipyretic, analgesic and anti-inflammatory effects of Kickxia ramosissima.

    Science.gov (United States)

    Jan, Shumaila; Khan, Muhammad Rashid

    2016-04-22

    Branched cancerwort, Kickxia ramosissima (Wall.) Janchen (Scrophulariaceae) is traditionally used for the treatment of inflammatory disorders such as rheumatism, diabetes, jaundice and for activation of immune system. Local communities also used this plant for the treatment of spleen enlargement, as febrifuge and in dysmenorrhea. In this investigation antipyretic, analgesic and anti-inflammatory effects of K. ramosissima have been evaluated. Dried powder of the whole plant of K. ramosissima was extracted with methanol (KRM) and partitioned with solvents to obtain the n-hexane (KRH), chloroform (KRC), ethyl acetate (KRE), n-butanol (KRB) and the residual aqueous (KRA) fraction. KRM and the derived fractions were analyzed for the phytochemical constituents, yeast induced pyrexia, analgesic and anti-inflammatory activities by using carrageenan and Freunds' complete adjuvant-induced paw edema model in rat. On account of appreciable effects of KRM in the aforesaid models, KRM was subjected to the carrageenan induced air pouch model in rat. The exudate of air pouch was analyzed for the count of neutrophils, monocytes, lymphocytes and WBCs and for the estimation of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), nitric oxide (NO) and prostaglandin (PGE2). Phytochemical investigation of KRM indicated the existence of tannins, flavonoids, alkaloids, coumarins, cardiac glycosides, saponins, terpenoids and phlobatannins. Maximum concentration of total phenolic was determined in KRB followed by KRM while reverse was true for total flavonoids contents. KRM (200mg/kg) distinctly decreased the rectal temperature in yeast induced pyrexia comparable to standard, paracetamol. Pain sensation was effectively inhibited at 200mg/kg p.o. of KRM and KRB as manifested by a decrease (PAnti-inflammatory effects of KRM were evident and edema formation induced with carrageenan and Freunds' complete adjuvant-induced paw edema in rat was significantly (Pinflammatory mediators; IL-6, NO

  11. Five-year review of copper T intrauterine device use at the University of Calabar Teaching Hospital, Calabar

    Directory of Open Access Journals (Sweden)

    Iklaki CU

    2015-10-01

    Full Text Available Christopher U Iklaki, Anthony U Agbakwuru, Atim E Udo, Sylvester E Abeshi Department of Obstetrics and Gynaecology, University of Calabar, Calabar, Nigeria Background: The intrauterine devices (IUDs are widely used contraceptive methods all over the world today. They are effective and recommended for use up to 10 years. They are not without side effects, which often prompt the users to request for removal. Objective: To determine the utilization rate of copper T intrauterine contraceptive device (IUCD, side effects, and request for removal at the University of Calabar Teaching Hospital, Calabar. Methods: The data on usage of the various forms of temporary contraception provided by the Family Planning Clinic of this center from January 1, 2006 to December 31, 2010 were collated. The records of usage of IUCD during same period were carefully studied. Results: During this period, a total of 10,880 users were provided with various forms of contraceptives. Copper T IUD was the commonest form of contraception used at the University of Calabar Teaching Hospital Family Planning Unit over the period under review (2006–2010 with a rate of 4,069 (37.40%. There was a yearly higher request for IUCD over other forms of contraceptives over the period. Of a total of 4,069 users of the copper T IUD method over the period, 1,410 (34.65% belonged to the age group of 25–29 years. Eleven (4.61% of the users requested for its removal due to abnormal vaginal bleeding, while five (2.08% removed theirs due to abnormal vaginal discharge. The major reason for removal was the desire for pregnancy that accounted for 165 (70.26%, while one (0.51% was removed due to dysmenorrhea. Conclusion: The copper T380A was very effective, safe with fewer side effects, and easily available in this study. The request for removal is also low in our environment. Keywords: copper T380A, contraception, request for removal

  12. Application of uterine cavity gauze packing in the hemorrhage during cesarean section%宫腔纱条填塞对剖宫产术中出血的应用

    Institute of Scientific and Technical Information of China (English)

    何泽真; 车显

    2016-01-01

    Objective:To explore the application value of uterine cavity gauze packing in the hemorrhage during cesarean section. Methods:42 patients with hemorrhage during cesarean section were selected.They were given uterine cavity gauze packing for hemostasis.The vaginal bleeding amount,body temperature and lochia were recorded after postoperative 24 hours,48 hours and when taking gauze.The menstruation return,whether dysmenorrhea and contraceptive methods were given postpartum follow up. Results:41 cases had successful hemostasis and retention of the uterus,and the treatment success rate was 97.6%.1 case was given subtotal hysterectomy.Women were followed up for good recovery.Conclusion:Uterine cavity gauze packing in the treatment of the hemorrhage during cesarean section is economic and effective,improves the uterine retention rate of patients,protects the reproduction ability of patients.%目的:探讨宫腔填塞对剖宫产术中出血的应用价值。方法:收治剖宫产术中出血患者42例,均行子宫腔填塞纱条止血,记录术后24 h、48 h及取纱条时的阴道出血量、体温及恶露情况。产后随访月经复潮、有无痛经、避孕方法。结果:41例成功止血并保留子宫,治疗成功率97.6%;1例行子宫次全切除术。随访产妇恢复良好。结论:宫腔纱条填塞治疗剖宫产术中大出血经济、有效,提高患者子宫保留率,保障患者再生育能力。

  13. Effectiveness of manual therapies: the UK evidence report

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    Leininger Brent

    2010-02-01

    dysmenorrhea when compared to sham manipulation, or for Stage 1 hypertension when added to an antihypertensive diet. In children, the evidence is inconclusive regarding the effectiveness for otitis media and enuresis, and it is not effective for infantile colic and asthma when compared to sham manipulation. Massage is effective in adults for chronic low back pain and chronic neck pain. The evidence is inconclusive for knee osteoarthritis, fibromyalgia, myofascial pain syndrome, migraine headache, and premenstrual syndrome. In children, the evidence is inconclusive for asthma and infantile colic.

  14. Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

    Science.gov (United States)

    Jarrell, John

    2009-01-01

    Pelvic pain is a common condition that is associated with dysmenorrhea and endometriosis. In some women the severe episodes of cyclic pain change and the resultant pain becomes continuous and this condition becomes known as Chronic Pelvic Pain. This state can be present even after the appropriate medical or surgical therapy has been instituted. It can be associated with pain and tenderness in the muscles of the abdomen wall and intra-pelvic muscles leading to severe dyspareunia. Additional symptoms of irritable bowel and interstitial cystitis are common. A common sign of the development of this state is the emergence of cutaneous allodynia which emerges from the so-called viscero-somatic reflex. A simple bedside test for the presence of cutaneous allodynia is presented that does not require excessive time or special equipment. This test builds on previous work associated with changes in sensation related to gall bladder function and the viscera-somatic reflex(1;2). The test is undertaken with the subject s permission after an explanation of how the test will be performed. Allodynia refers to a condition in which a stimulus that is not normally painful is interpreted by the subject as painful. In this instance the light touch associated with a cotton-tipped applicator would not be expected to be painful. A positive test is however noted by the woman as suddenly painful or suddenly sharp. The patterns of this sensation are usually in a discrete pattern of a dermatome of the nerves that innervate the pelvis. The underlying pathology is now interpreted as evidence of neuroplasticity as a consequence of severe and repeating pain with changes in the functions of the dorsal horns of the spinal cord that results in altered function of visceral tissues and resultant somatic symptoms(3). The importance of recognizing the condition lies in an awareness that this process may present coincidentally with the initiating condition or after it has been treated. It also permits the

  15. Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

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    Guo S

    2017-03-01

    Full Text Available Song Guo,1,* Xiaowei Lu,1,* Ruihuan Gu,2 Di Zhang,3 Yijuan Sun,2 Yun Feng1 1Department of Obstetrics and Gynecology, Reproductive Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Gynecology, Shanghai Ji Ai Genetics & In Vitro Fertilization Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People’s Republic of China; 3Department of Gynecology and Obstetrics, Jinan Military General Hospital, Jinan, People’s Republic of China *These authors contributed equally to this work Purpose: Adenomyosis is a common, benign gynecological condition of the female reproductive tract characterized by heavy menstrual bleeding and dysmenorrhea. Gonadotropin-releasing hormone (GnRH agonists are one of the medications used in adenomyosis treatment; however, their underlying mechanisms are poorly understood. Moreover, it is difficult to obtain endometrial samples from women undergoing such treatment. To overcome this, we generated an adenomyosis mouse model, which we treated with an GnRH agonist to determine its effect on pregnancy outcomes. We also analyzed endometrial gene expression following GnRH agonist treatment to determine the mechanisms that may affect pregnancy outcome in individuals with adenomyosis.Methods: Neonatal female mice were divided into a control group, an untreated adenomyosis group, and an adenomyosis group treated with a GnRH agonist (n=6 each. The pregnancy outcome was observed and compared among the groups. Then, three randomly chosen transcriptomes from endometrial tissues from day 4 of pregnancy were analyzed between the adenomyosis group and the GnRH agonist treatment group by RNA sequencing and quantitative reverse transcription polymerase chain reaction (PCR.Results: The litter size was significantly smaller in the adenomyosis group than in the control group (7±0.28 vs 11±0.26; P<0.05. However, the average live litter

  16. Alcoolização de miomas uterinos: uma nova estratégia terapêutica Ethanol sclerotherapy for uterine myomas: A new therapeutic strategy

    Directory of Open Access Journals (Sweden)

    Lucilo Ávila

    2002-01-01

    Full Text Available O estudo avaliou a segurança, eficácia e resultados da técnica de alcoolização para tratamento da miomatose uterina. Analisou-se uma série de 20 pacientes (idade variando entre 20 e 40 anos submetidas a alcoolização para tratamento de miomatose uterina sintomática. O procedimento foi realizado sob anestesia geral, guiado por ultra-sonografia transvaginal. Realizou-se seguimento clínico e ultra-sonográfico (ultra-sonografia transvaginal e doppler colorido com um e seis meses depois do tratamento. Analisaram-se os parâmetros: frequência de sintomas, mapa vascular (doppler e tamanho da tumoração. Utilizaram-se os testes do qui-quadrado e Mann-Whitney. Significância pThe aim of this study was to evaluate the safety, efficacy and outcome of ethanol sclerotherapy for uterine myomata. This is a series of 20 patients (aged 20 to 40 years with symptomatic uterine myomata submitted to ethanol sclerotherapy. The procedure was performed under sedation and guided by transvaginal ultrasound. The patients were followed clinically and ultrasonically (transvaginal sonography and color Doppler evaluation one month and six months after treatment. The frequency of symptoms, intratumoral color flow mapping and tumoral size were analyzed. Chi-square and Mann-Whitney tests were used at a 5% level of significance. Postprocedure complications were not observed. A significant relief of dysmenorrhea was observed with one and six months and the frequency of pelvic pain and menorrhagia was significantly reduced with six months. A significant reduction of tumoral size was observed, from 89,4 cm3 (inicial volume to 73,5 cm3 e 69,9 cm3 (one and six months, respectively. The frequency of intratumoral high blood flow was 80% before and 15% and 20% one and six months after the procedure (p=0,0001. It can be concluded that these preliminary results indicate that transvaginal ultrasound-guided ethanol sclerotherapy can be an effective treatment for uterine myomas

  17. Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity.

    Directory of Open Access Journals (Sweden)

    Iñaki González-Foruria

    Full Text Available Endometriosis is a benign gynaecological disease. Abundant bulk of evidence suggests that patients with endometriosis have an immunity dysfunction that enables ectopic endometrial cells to implant and proliferate. Previous studies show that natural killer cells have a pivotal role in the immune control of endometriosis.This is a prospective laboratory study conducted in a tertiary-care university hospital between January 2011 and April 2013. We investigated non-pregnant, younger than 42-year-old patients (n= 202 during surgery for benign gynaecological conditions. After complete surgical exploration of the abdominopelvic cavity, 121 women with histologically proven endometriosis and 81 endometriosis-free controls women were enrolled. Patients with endometriosis were classified according to a surgical classification in three different types of endometriosis: superficial peritoneal endometriosis (SUP, ovarian endometrioma (OMA and deep infiltrating endometriosis (DIE. Peritoneal fluid samples were obtained from all study participants during the surgery in order to detect soluble NKG2D ligands (MICA, MICB and ULBP-2. When samples with undetectable peritoneal fluid levels of MICA, MICB and ULBP-2 were excluded, MICA ratio levels were significantly higher in endometriosis patients than in controls (median, 1.1 pg/mg; range, 0.1-143.5 versus median, 0.6 pg/mg; range, 0.1-3.5; p=0.003. In a similar manner peritoneal fluid MICB levels were also increased in endometriosis-affected patients compared with disease-free women (median, 4.6 pg/mg; range, 1.2-4702 versus median, 3.4 pg/mg; range, 0.7-20.1; p=0.001. According to the surgical classification, peritoneal fluid soluble MICA, MICB and ULBP-2 ratio levels were significantly increased in DIE as compared to controls (p=0.015, p=0.003 and p=0.045 respectively. MICA ratio levels also correlated with dysmenorrhea (r=0.232; p=0.029, total rAFS score (r=0.221; p=0.031 and adhesions rAFS score (r=0.221; p=0

  18. Age at menarche and menstrual cycle pattern among school adolescent girls in Central India.

    Science.gov (United States)

    Dambhare, Dharampal G; Wagh, Sanjay V; Dudhe, Jayesh Y

    2012-01-01

    The onset of menstruation is part of the maturation process. However, variability in menstrual cycle characteristics and menstrual disorders are common. The purpose of this study was to determine the age at menarche and patterns of menstruation among school adolescent girls and explore its variation across socio-economic and demographic factors. This is a cross-sectional descriptive study carried out on 1100 school adolescent girls in district Wardha, Central India. Data were collected using a self-administered structured questionnaire on menstruation. Data was entered and analyzed by using Epi Info 6.04 software package. Chi- square value was used for testing statistical significance. Mean ages of menarche were 13.51 + 1.04 years and 13.67 + 0.8 years for urban and rural areas respectively. Abnormal cycle length was common and affected 30.48%. The majority 56.15 experienced dysmenorrhoea and 56.16 percent had premenstrual syndrome. Self medication was practiced by 7.13% of the adolescent girls. The most common premenstrual symptom was headache 26.74%. Absenteeism from the school 13.9% was the effect of menstruation related problems on their daily routine. Dysmenorrhea and premenstrual symptoms were perceived as most distressing symptoms leading to school absenteeism. Majority of the girls 75.58% had discussed menstrual problems with someone, most commonly with their mothers 38.15%. There was a general lack of information about menstrual issues especially with regards to cycle length, duration of menses and age at menarche. Girls from families of high socio-economic class have significantly lower mean menarcheal age in both urban and rural area. The mean age of menarche was significantly higher in girls involved in vigorous sporting activity in urban area compared to their non-sporting counterparts. Age at menarche was delayed. The menstrual disorders among female adolescents are common. A school health education on menstrual problems targeting adolescent girls and

  19. [Disease and contraception. Recent aspects].

    Science.gov (United States)

    Rozenbaum, H

    1985-01-01

    This article reviews several different articles which have contributed to an understanding of the harmful or beneficial effects of oral contraceptives (OCs) on various diseases. The Royal College of General Practitioners study found that current OC users compared to women who had never used OCs had relative risks of .52 for menorrhagia, .37 for dysmenorrhea, .65 for irregular cycles, .72 for intermenstrual bleeding, and .71 for premenstrual syndrome. Several studies found combined OCs to offer protection against ovarian cysts. Microdose progestin only pills did not ameliorate most menstrual problems and aggravated ovarian cysts. Despite some theoretical grounds for suspecting an association between pituitary prolactinomas and OC use, recent studies have failed to find an increased relative risk for prolactinomas in women using OCs for contraceptive purposes, although 1 study found an increased risk in women using OCs for cycle control. 1 study reported 11 pregnancies in 30 diabetic women in 15 months of IUD use; the high rate was attributed to abnormal patterns of mineral deposit on the IUD surface. The 11 pregnancies occurred with 5 Gravigardes, 5 Saf-T-Coils, and 1 Dalkon Shield. Other studies on the contrary have noted no difference in pregnancy rates among 103 diabetic women using Copper Ts or 118 diabetic women using Lippes loops. Combined OCs appear to reduce the incidence of rheumatoid arthritis by 1/2 among current OC users and to protect former users as well. Combined OCs aggravate lupus erythmatous but synthetic progestins alone are effective without aggravating the condition. It has recently been argued that low dose OCs are not contraindicated in cases of sickle cell disease and may even offer protection against thromboembolic vascular accidents for women with sickle cell anemia. Estimates of relative risk of pelvic infection among IUD users vary from 1.5 to 6.5, with the risk apparently greatest for women under 25. Recent studies have indicated that

  20. Attributes and Barriers to Care of Pelvic Pain in University Women

    Science.gov (United States)

    Mann, Julie; Shuster, Jonathan; Moawad, Nash

    2014-01-01

    Study Objective To describe rates of pelvic pain in university women ages 18 and older and to explore the barriers to adequate health care for pelvic pain in this population. Design A cross-sectional study (Canadian Task Force classification II-2). Setting University of Florida, Gainesville, FL. Patients A total of 2000 female students at the University of Florida were randomly selected for participation. Interventions The 2000 sample members were sent a questionnaire to be completed online. Measurements and Main Results The online questionnaire was hosted through the REDCap electronic data capture tool hosted at the University of Florida. This questionnaire included demographic items, general health and health behavior questions, measures to assess different types of pelvic pain (e.g., dysmenorrheal; dyspareunia; urinary, bowel, and vulvar pain), items regarding barriers to care for pelvic pain problems, and quality of life measures. Data were exported to SAS software (SAS Institute Inc., Cary, NC) for analysis. Of the 2000 subjects who received the questionnaire invitation, 390 filled out the questionnaire, yielding a response rate of 19.5%. Respondents’ ages ranged from 18 to 62 with a mean of 23 years. A total of 72.8% of respondents reported experiencing pelvic pain over the past 12 months. Dysmenorrhea was reported by nearly 80% of participants, over one third of participants noted deep dyspareunia, and a significant proportion of participants reported symptoms related to bowel movements. Vulvar symptoms, including superficial dyspareunia, were reported by 21.5% of participants. Most participants with pelvic pain (78.8%) have not received any diagnosis for their pain, whereas 73.6% reported not yet having visited a doctor. Significant barriers to receiving adequate medical care were reported, including difficulty with insurance coverage and physicians’ lack of time and knowledge or interest in chronic pelvic pain conditions. Conclusion Pelvic pain in

  1. Research Progress of Acupuncture and Moxibustion in the Treatment of Diabetic Peripheral Neuropathy%针灸治疗糖尿病合并周围神经病变的研究进展

    Institute of Scientific and Technical Information of China (English)

    张彩红

    2016-01-01

    Diabetic peripheral neuropathy ( DPN ) , as one of the common complications of diabetes , has a very high morbidity .Clinical performance is acromegaly paresthesia , numbness, pain, severe muscle atrophy and even partial paralysis , which made a great impact on people’ s healthy life.Treatment for this disease are general common improving local blood circulation , nutrition, Chinese medicine acupuncture and moxibustion with regulating qi and blood , the role of dysmenorrhea pain , which had obvious treatment value for DPN patients.In recent years , a large number of clinical reports for the old patients with DPN given acupuncture and moxibustion therapy can achieve good curative effect .Through the review of acupuncture and moxibustion in the treatment of DPN in recent years , the article showed that specific methods and effects of clinical application of acupuncture and moxibustion therapy .%糖尿病周围神经病变( DPN)作为糖尿病常见并发症之一,具有极高的致残率。临床上表现为肢端感觉异常、麻木、疼痛,病情严重出现肌肉萎缩甚至局部瘫痪,对人们健康生活造成极大影响,治疗本病的方法常见的改善局部血液循环,营养神经,中医针灸具有调节气血,通经活络的作用,对于DPN患者的具有比较明显的治疗价值,近年来大量临床报道显示对老年DPN患者给予针灸治疗能够取得良好疗效,文章通过对近几年的针灸治疗DPN的回顾,说明针灸治疗的临床运用的具体的方法和作用。

  2. 浅析阿司匹林抵抗产生的机理与防治措施%Brief Analysis on the Generation Mechanism of Aspirin Resistance and Control Measures

    Institute of Scientific and Technical Information of China (English)

    卫东

    2011-01-01

    Aspirin is the most used medicine with long time antipyretic, analgesic and anti-inflammatory, it can inhibit prostaglandin synthase of body temperature regulation center, making prostaglandin (pge1) synthesis and release decrease, thereby restoring the body normal reaction of temperature, so that achieving peripheral vasodilatation and perspiration with body temperature returning to normal. This product still has the function of anti-inflammatory, anti-rheumatic, and promoting the body's excretion of uric acid synthesized against platelet aggregation, which is suitable for alleviating fever and moderate pain such as arthritis, neuralgia, muscle pain, headache, migraine, dysmenorrhea, toothache, sore throat, colds and flu symptoms. But despite regular taking aspirin for the clinical 5% to 60% of patients, it can not effectively inhibit platelet activity, a phenomenon known as aspirin resistance. Combined with years of experience and based on the pharmacokinetics of aspirin, the resistance mechanism of aspirin and its control measures are discussed.%阿司匹林是使用最多、使用时间长的解热、镇痛和消炎药物,能抑制体温调节中枢的前列腺素合成酶,使前列腺素(pge1)合成、释放减少,从而恢复体温中枢的正常反应性,使外周血管扩张并排汗,使体温恢复正常.本品尚具抗炎、抗风湿作用,并促进人体内所合成的尿酸的排泄,对抗血小板的聚集.适用于解热,减轻中度疼痛如关节炎、神经痛、肌肉痛、头痛、偏头痛、痛经、牙痛、咽喉痛、感冒及流感症状.但是临床上有5%~60%的患者虽常规服用阿司匹林,却不能有效地抑制血小板的活性,这种现象被称为阿司匹林抵抗,本文结合多年经验,以研究阿司匹林动力学为基础,探讨了阿司匹林抵抗机理及其防治措施.

  3. A pharmacokinetic comparison of single doses of once-daily cyclobenzaprine extended-release 15 mg and 30 mg: a randomized, double-blind, two-period crossover study in healthy volunteers.

    Science.gov (United States)

    Darwish, Mona; Chang, Steven; Hellriegel, Edward T

    2009-01-01

    The purpose of this study was to compare the pharmacokinetics and tolerability of single oral doses of cyclobenzaprine extended-release (CER) 15- and 30-mg capsules. This was a randomized, double-blind, 2-period crossover study in healthy adults aged 18 to 40 years. Subjects were assigned to receive a single dose of either CER 15 mg or 30 mg on days 1 and 15, separated by a 14-day washout. Study comparisons included the plasma cyclobenzaprine AUC to 168 hours after dosing (AUC(0-168)), AUC(0-infinity), and C(max). Plasma cyclobenzaprine T(max), terminal elimination t(1/2), and adverse events (AEs) were also assessed. Sixteen subjects (9 women, 7 men) were randomized to receive cyclobenzaprine 15 mg or 30 mg; 13 (81.3%) were white and 3 (18.8%) were black. Mean age and weight were 30.2 years and 70.7 kg, respectively. The shapes of the pharmacokinetic profiles for CER 15 and 30 mg were parallel. Mean observed values for dose-dependent pharmacokinetic parameters of CER 15 and 30 mg were as follows: AUC(0-168), 318.3 and 736.6 ng . h/mL, respectively; AUC(0-infinity)), 354.1 and 779.9 ng . h/mL; and C(max), 8.3 and 19.9 ng/mL. Dose-independent parameters were comparable across doses. Median observed Tmax was 6.0 hours for both CER doses; mean t(1/2) was 33.4 hours for CER 15 mg and 32.0 hours for CER 30 mg. The bioavailability of the 2 doses, as indicated by the least squares mean AUC(0-infinity), was 330.3 ng . h/mL for CER 15 mg and 755.1 ng . h/mL for CER 30 mg. During the CER 15-mg treatment sequence, 5 subjects experienced 5 AEs (headache, dizziness, musculoskeletal pain, dermatitis, and glossodynia); during the CER 30-mg treatment sequence, 2 subjects experienced 2 AEs (somnolence and dysmenorrhea). All AEs were mild in intensity. No serious AEs occurred during the study. Once-daily CER 15 and 30 mg exhibited similarly shaped pharmacokinetic profiles. AUC(0-168), AUC(0-infinity)), and C(max) values for the 30-mg dose were approximately double those for the 15-mg

  4. Comparisons of pharmacokinetic and tissue distribution profile of four major bioactive components after oral administration of Xiang-Fu-Si-Wu Decoction effective fraction in normal and dysmenorrheal symptom rats.

    Science.gov (United States)

    Liu, Pei; Li, Wei; Li, Zhen-hao; Qian, Da-wei; Guo, Jian-ming; Shang, Er-xin; Su, Shu-lan; Tang, Yu-ping; Duan, Jin-ao

    2014-07-03

    Xiang-Fu-Si-Wu Decoction (XFSWD) has been widely used to treat primary dysmenorrhea in clinical practice for hundreds of years and shown great efficacy. One fraction of XFSWD, which was an elution product by macroporous adsorption resin from aqueous extract solution with 60% ethanol (XFSWE), showed great analgesic effect. The present study was conducted to investigate the possible pharmacokinetic and tissue distribution profiles of four major bioactive constituents (berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine) after oral administration of XFSWE in dysmenorrheal symptom rats, and to compare the difference between normal and dysmenorrheal symptom rats. Estradiol benzoate and oxytocin were used to produce dysmenorrheal symptom rat model. The experimental period was seven days. At the final day of experimental period, both normal and dysmenorrheal symptom rats were orally administrated with XFSWE, and then the blood and tissues samples were collected at different time points. Berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine in blood and tissue samples were determined by LC-MS/MS. Pharmacokinetic parameters were calculated from the plasma concentration-time data using non-compartmental methods. The differences of pharmacokinetic parameters among groups were tested by one-way analysis of variance (ANOVA). There were statistically significant differences (Pnormal and dysmenorrheal symptom rats that orally administered with same dosage of XFSWE. In tissue distribution study, the results showed that the overall trend was C(Spleen)>C(Liver)>C(Kidney)>C(Uterus)>C(Heart)>C(Lung)>C(Ovary)>C(Brain)>C(Thymus), C(M-60 min)>C(M-120 min)>C(M-30 min)>C(C-60 min)>C(C-120 min)>C(C-30 min). The contents of protopine in liver, spleen and uterus were more than that in other tissues of dysmenorrheal symptom rats. Compared to normal rats, partial contents of the compounds in dysmenorrheal symptom rats׳ tissues at different time points had significant

  5. Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae)

    Science.gov (United States)

    Michel, Joanna L; Chen, Yegao; Zhang, Hongjie; Huang, Yue; Krunic, Alecjev; Orjala, Jimmy; Veliz, Mario; Soni, Kapil K.; Soejarto, Djaja Doel; Caceres, Armando; Perez, Alice; Mahady, Gail B

    2010-01-01

    Ethnopharmacological relevance Our previous work has demonstrated that several plants in the Piperaceae family are commonly used by the Q’eqchi Maya of Livingston, Guatemala to treat amenorrhea, dysmenorrhea, and pain. Extracts of Piper hispidum Swingle (Piperaceae), bound to the estrogen (ER) and serotonin (5-HT7) receptors. Aim of the study To investigate the estrogenic and serotonergic activities of P. hispidum extracts in functionalized assays, identify the active chemical constituents in the leaf extract, and test these compounds as agonists or antagonists of ER and 5-HT7. Materials and methods The effects of the P. hispidum leaf extracts were investigated in estrogen reporter gene and endogenous gene assays in MCF-7 cells to determine if the extracts acted as an estrogen agonist or antagonist. In addition, the active compounds were isolated using ER- and 5-HT7 receptor bioassay-guided fractionation. The structures of the purified compounds were identified using high-resolution LC-MS and NMR spectroscopic methods. The ER- and 5-HT7-agonist effects of the purified chemical constituents were tested in a 2ERE-reporter gene assay in MCF-7 cells and in serotonin binding and functionalized assays. Results Three butenolides including one new compound (1) were isolated from the leaves of P. hispidum, and their structures were determined. Compound 1 bound to the serotonin receptor 5-HT7 with IC50 values of 16.1 and 8.3 μM, respectively, and using GTP shift assays, compound 1 was found to be a partial agonist of the 5-HT7 receptor. The P. hispidum leaf extracts, as well as compounds 2 and 3 enhanced the expression of estrogen responsive reporter and endogenous genes in MCF-7 cells, demonstrating estrogen agonist effects. Conclusions Extracts of P. hispidum act as agonists of the ER and 5-HT7 receptors. Compound 1, a new natural product, identified as 9, 10-methylenedioxy-5,6-Z-fadyenolide, was isolated as the 5-HT7 agonist. Compounds 2 and 3 are reported for the

  6. The Clinical Efficacy of LNG-IUS in the Treatment of Menstrual Abnormalities and Anemia of Adenomyosis%放置曼月乐治疗子宫腺肌病患者月经异常和贫血的疗效分析

    Institute of Scientific and Technical Information of China (English)

    郝茜

    2009-01-01

    目的 探讨曼月乐对子宫腺肌病患者月经异常和贫血的临床效果.方法 对86例子宫腺肌病患者放置曼月乐后进行6个月的随访,在1、2、4、6个月时利用VAS评分法分析患者痛经程度、月经量、经期以及贫血症状情况.结果 患者痛经评分、月经量运月下降,在1、2、4、6个月时,较放置前有明显下降(P<0.05或P<0.01),经期在第6个月时明显缩短(P<0.01);贫血症患者比例逐月降低,较放置前有明显下降(P<0.05或P<0.01).结论 曼月乐是治疗子宫腺肌病的一种较为有效且安全的方法.%OBJECTIVE To investigate the the clinical efficacy of levonorgestrel-releasing intrauterine system(LNG-IUS)in the treatment of adenomyosis. METHODS Eighty six patients with adenomysois were followed up in 0,1,2,4,6 months after treating with LNG-IUS, dysmenorrhea, menstrual blood volume, menstrual period and anemia of the patients. RESULTS Dysmenorrheal scores and menstrual blood volume of the patients decreased gradually after LNG-IUS, it was decreased significantly (P<0.05 or P<0.01 ), when the sixth moth menstrual period of patients was less than it when before LNG-IUS, anemia of adenomyosis was decreased gradually after LNG-IUS, and it were decreased significantly(P<0.05 or P<0.01 ). CONCLUSIONS LIG-IUS is an effective and safe therapy for adenomyosis.

  7. Effectiveness of manual therapies: the UK evidence report.

    Science.gov (United States)

    Bronfort, Gert; Haas, Mitch; Evans, Roni; Leininger, Brent; Triano, Jay

    2010-02-25

    The purpose of this report is to provide a succinct but comprehensive summary of the scientific evidence regarding the effectiveness of manual treatment for the management of a variety of musculoskeletal and non-musculoskeletal conditions. The conclusions are based on the results of systematic reviews of randomized clinical trials (RCTs), widely accepted and primarily UK and United States evidence-based clinical guidelines, plus the results of all RCTs not yet included in the first three categories. The strength/quality of the evidence regarding effectiveness was based on an adapted version of the grading system developed by the US Preventive Services Task Force and a study risk of bias assessment tool for the recent RCTs. By September 2009, 26 categories of conditions were located containing RCT evidence for the use of manual therapy: 13 musculoskeletal conditions, four types of chronic headache and nine non-musculoskeletal conditions. We identified 49 recent relevant systematic reviews and 16 evidence-based clinical guidelines plus an additional 46 RCTs not yet included in systematic reviews and guidelines.Additionally, brief references are made to other effective non-pharmacological, non-invasive physical treatments. Spinal manipulation/mobilization is effective in adults for: acute, subacute, and chronic low back pain; migraine and cervicogenic headache; cervicogenic dizziness; manipulation/mobilization is effective for several extremity joint conditions; and thoracic manipulation/mobilization is effective for acute/subacute neck pain. The evidence is inconclusive for cervical manipulation/mobilization alone for neck pain of any duration, and for manipulation/mobilization for mid back pain, sciatica, tension-type headache, coccydynia, temporomandibular joint disorders, fibromyalgia, premenstrual syndrome, and pneumonia in older adults. Spinal manipulation is not effective for asthma and dysmenorrhea when compared to sham manipulation, or for Stage 1

  8. Clinical efficiency of Levonorgestrel-releasing intrauterine system in the treatment of 69 cases with adenomyosis%左炔诺孕酮宫内节育系统治疗子宫腺肌病的临床观察

    Institute of Scientific and Technical Information of China (English)

    居蓉

    2014-01-01

    Objective To evaluate the clinical efficiency of Levonorgestrel-releasing intrauterine system(LNG-IUS) in the treatment of adenomyosis. Methods Sixty-nine patients with adenomyosis were treated with LNG-IUS during March 2011 to June 2013. The menstrual quality,menstrual period,VAS and VRS score were carried out before treatment and at one,three and six months after treatment. The amount and period of menstruation were valued by test. Results Among 69 patients, menstrual quality were reduced, dysmenorrhea and chronic pelvic pain were alleviated, which were significantly different from those before treatment(P<0.05).Conclusion LNG-IUS inserting inside uterine cavity can significantly alleviate the clinical symptoms of adenomyosis and improve the patients quality.%目的:观察左炔诺孕酮宫内节育系统(LNG-IUS)治疗子宫腺肌病所致痛经、月经过多及慢性盆腔痛的临床疗效。方法选取2011年3月~2013年6月门诊确诊子宫腺肌病患者69例,排除禁忌证后给予放置左炔诺孕酮宫内节育系统治疗,随访6个月,观察患者的月经量、月经期、痛经及慢性盆腔痛的改善情况。结果与放置左炔诺孕酮宫内节育系统前相比,放置后患者月经量明显减少,痛经程度、慢性盆腔痛明显改善,差异均具有统计学意义(P<0.05)。结论左炔诺孕酮宫内节育系统可以有效缓解子宫腺肌病临床症状,提高患者生活质量。

  9. 广东省江门市区妇女乳腺疾病调查及相关风险因素分析%Prevalence and related risk factors of breast disease in women in urban area of Jiangmen, Guangdong

    Institute of Scientific and Technical Information of China (English)

    陆珊珊; 林颖; 冯持真

    2012-01-01

    目的 探讨广东省江门市区妇女乳腺疾病发生的相关风险因素,为乳腺疾病的防治提供参考依据.方法 2009年5月至2010年12月对江门市区12 365名妇女进行乳腺疾病筛查.结果 江门市区妇女乳腺疾病的患病率达34.51%,乳腺癌检出率为150/10万.高学历、痛经、饮酒、乳腺自检与乳腺疾病呈正相关(OR值分别为1.10、1.15、1.35、1.12),初潮年龄晚、月经周期长、绝经与乳腺疾病呈负相关(OR值分别为0.96、0.99、0.62).结论 育龄妇女是乳腺疾病重点防治对象.乳腺疾病筛查应作为妇女保健工作的重点,妇女应适时婚育、合理膳食、学习乳腺自我检查、提高自我保健意识.%Objective To understand the prevalence and related risk factors of breast disease in women in the urban area of Jiangmen and provide evidence for the prevention and treatment of breast disease. Methods From May 2009 to December 2010,a breast disease screening was conducted in 12 365 women in the urban area in Jiangmen. Results The prevalence of breast disease in women was 34. 51 % and the detection rate of breast cancer was 150/lakh. High education level, dysmenorrhea, alcohol use and breast self examination were positively correlated with breast disease (OR = 1. 10, 1.15, 1.35, 1.12). Late menarche, long menstrual cycle, menopause were negatively correlated with breast diseases ( OR = 0. 96, 0. 99, 0. 62). Conclusion Child bearing aged women are the key population in breast disease prevention and treatment. Breast disease screening is one of the priorities in women health care, and women' s self health care, being married and having baby at appropriate time, having healthy diet and breast self examination, is important to reduce the risk of breast disease.

  10. Breakfast:to eat or to skip?%早餐:吃还是不吃?

    Institute of Scientific and Technical Information of China (English)

    王佳佳; 郭静; 许红霞

    2015-01-01

    Objective As more people choose to skip breakfast, this study is to evaluate the impact of breakfast skipping (BS) on human health. Methods We collected and analyzed the results from observational studies, RCT studies, meta analysis and other reviews. Results These studies indicated that BS is associated with high risk of type 2 diabetes, high cardiometabolic risk factors, bone mass loss, and dysmenorrhea in young women. It worsens cognitive outcomes in malnourished children and adolescence. Some evidence established a link between obesity and BS, but some authors argued that the proposed effect of BS on obesity has not yet to establish a causal relationship. In the studies we reviewed, the duration of overnight fasting is rarely speciifed. Including this factor in the studies might result in different conclusions. Conclusions We would suggest that breakfast is as important as other meals of the day. Well-designed epidemiological studies are needed before we can reach further conclusions.%目的不吃早餐(breakfastskipping,BS)的人日益增多,本文讨论不吃早餐对健康的影响。方法通过文献检索,对观察性研究、随机对照研究、meta分析等文献进行综合评述。结果多数研究倾向于吃早餐与低BMI水平有关,不吃早餐可能增加体重,但其因果关系没有得到确认,可能与多数研究没有考虑“过夜禁食时间”有关。不吃早餐还与糖尿病及心血管疾病发病风险增加、骨密度丢失、女性痛经等有关,甚至可能影响儿童及青少年认知能力。结论需要更大样本量、更严谨设计的前瞻性研究才能获得科学的结论,可能早餐只是一天中的一餐,而不一定是“一天中最重要的一餐”。

  11. Screening of breast diseases and investigation on related factors among the married women in rural area of Bangbu city%蚌埠市农村已婚妇女乳腺疾病筛查及相关因素调查

    Institute of Scientific and Technical Information of China (English)

    高攀; 张秀军; 于玉领; 余国斌; 孙业桓

    2012-01-01

    . Multivariate logistic regression analysis showed that compared with the rural married women of childbearing age with junior high school educational level or above, without dysmenorrhea, induced abortion history, and abortion history, the women with primary school educational level or above, with dysmenorrhea, induced abortion history, and abortion history had higher risk of breast diseases; compared with the rural married women of childbearing age with age ≤ 29 years, menstrual cycle ≤ 24 days, low amount of menstruation, and average annual family income =≤5 000 Yuan, the women with age >29 years, long menstrual cycle, high amount of menstruation, and high average annual family income had higher risk of breast diseases. Conclusion; The incidences of breast diseases are relatively high among the rural married women, and they are affected by many factors, general investigation should be carried out regularly, and secondary prevention of breast diseases should be enhanced.

  12. 育龄人群不孕不育影响因素分析%Analysis on the effect factors of infertility among the population of childbearing age

    Institute of Scientific and Technical Information of China (English)

    于建春; 王苏梅; 刘秀丽; 林静; 宁鲁勇; 刘华强; 王平; 刘向东

    2012-01-01

    , menstrual cycle, menstrual volume, dysmenorrhea, secondary amenorrhea, uterine diseases, ovarian diseases, tubal diseases, cervical diseases, vaginal section, peculiar smell of vaginal section, pelvic infection, times of induced abortion, times of curettage of uterine cavity, times of induce abortionwith drug, ectopic pregnancy, times of abdominal surgery, medical history of mental diseases, medical history of lower abdominal pain, taking medicine for a long time, separation in two places, taking contraceptive drugs, using intrauterine device, history of exposure to haz-ardous substances, adverse life history, and mental stress. The effect factors of male infertility included occupation, educational level, average per capita income, body height, body weight, chromosomal diseases, testicular diseases, epididymal diseases, tubal diseases, disorder of ejaculation, medical history of hyperpyrexia, varicocele, history of exposure to hazardous substances, working strength, working at high temperature, exposure to noises, and mental stress. The results of multivariate analysis showed that the effect factors of infertile population of childbearing age included menstrual volume, dysmenorrhea, uterine diseases, tubal diseases, times of curettage of uterine cavity, separation in two places, female mental stress, male occupation, male body weight, and testicular diseases. Conclusion: Enhancing publicity, improving the quality of population of childbearing age, strengthening management, providing high quality service for population of childbearing age, enhancing reproductive health education may reduce the incidence of infertility.

  13. Clinical analysis of efficacy and quality of life of segmental bowel resection for bowel endometriosis%节段性肠切除术治疗肠道子宫内膜异位症患者的临床疗效及生命质量分析

    Institute of Scientific and Technical Information of China (English)

    刘多; 沈慧敏; 梁炎春; 王伟; 刘田雨; 尚春亮; 姚书忠

    2016-01-01

    Objective To evaluate the efficacy and quality of life of segmental bowel resection for bowel endometriosis. Methods Totally 62 symptomatic patients with bowel endometriosis undergoing segmental bowel resection were recruited. A visual analogue scale (VAS) and the 36-item short form health survey (SF-36) questionnaire were administered before and at least 1 year after surgery, respectively. Pregnancy rates were also recorded. Results Sixty-two patients in total underwent follow-up ranging from 12 to 74 months. All patients complained of obvious pain symptoms, including dysmenorrhea, dyspareunia, pain on defecation and chronic pelvic pain. The relief of dysmenorrhea (2.9 ± 2.2 versus 7.5 ± 2.9), dyspareunia (0.7 ± 0.5 versus 4.3 ± 2.2) and pain on defecation (1.6 ± 0.7 versus 7.3 ± 1.9) after surgery was statistically significant (all P<0.01). The scores for all 8 domains of the SF-36 questionnaire were significant improved after segmental bowel resection (al