WorldWideScience

Sample records for dynamic system immortalizing

  1. Brain Prostheses as a Dynamic System (Immortalizing the Human Brain?)

    CERN Document Server

    Astakhov, Vadim

    2007-01-01

    Interest in development of brain prostheses, which might be proposed to recover mental functions lost due to neuron-degenerative disease or trauma, requires new methods in molecular engineering and nanotechnology to build artificial brain tissues. We develop a Dynamic Core model to analyze complexity of damaged biological neural network as well as transition and recovery of the system functionality due to changes in the system environment. We provide a method to model complexity of physical systems which might be proposed as an artificial tissue or prosthesis. Delocalization of Dynamic Core model is developed to analyze migration of mental functions in dynamic bio-systems which undergo architecture transition induced by trauma. Term Dynamic Core is used to define a set of causally related functions and Delocalization is used to describe the process of migration. Information geometry and topological formalisms are proposed to analyze information processes. A holographic model is proposed to construct dynamic e...

  2. Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.

    Directory of Open Access Journals (Sweden)

    Masao Takeuchi

    Full Text Available Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation. To further address these questions, we performed whole transcriptome analysis to the human mesenchymal stem cell line, UE6E7T-3, which was immortalized with hTERT and human papillomavirus type 16 E6/E7 genes, in association with progress of transformation in these cells. At early stages of culture, UE6E7T-3 cells preferentially lost one copy of chromosome 13, as previously described; in addition, tumor suppressor genes, DNA repair genes, and apoptosis-activating genes were overexpressed. After the loss of chromosome 13, additional aneuploidy and genetic alterations that drove progressive transformation, were observed. At this stage, the cell line expressed oncogenes as well as genes related to anti-apoptotic functions, cell-cycle progression, and chromosome instability (CIN; these pro-tumorigenic changes were concomitant with a decrease in tumor suppressor gene expression. At later stages after prolong culture, the cells exhibited chromosome translocations, acquired anchorage-independent growth and tumorigenicity in nude mice, (sarcoma and exhibited increased expression of genes encoding growth factor and DNA repair genes, and decreased expression of adhesion genes. In particular, glypican-5 (GPC5, which encodes a cell-surface proteoglycan that might be a biomarker for sarcoma, was expressed at high levels in association with transformation. Patched (Ptc1, the cell surface receptor for hedgehog (Hh signaling, was also significantly overexpressed and co-localized with GPC5. Knockdown of GPC5 expression decreased cell proliferation, suggesting that it plays a key role in growth in U3-DT cells (transformants derived from UE6E7T-3 cells through the Hh signaling pathway. Thus, the UE6E7T-3 cell culture model is a useful tool for assessing the functional

  3. Three-dimensional culture system can induce expression of casein in immortalized bovine mammary epithelial cells.

    Science.gov (United States)

    Zhan, Kang; Lin, Miao; Liu, MingMei; Sui, YangNan; Babekir, Haitham Mohammed; Zhao, GuoQi

    2017-05-01

    Primary bovine mammary epithelial cells (BMECs) are not ideal models for long-term studies of lactation mechanisms because these cells in a monolayer culture system cannot be polarized to simulate the physiological functions in vitro. We investigate the effects of different culture models and karyotypes on casein expression in a three-dimensional (3D) culture system. The immortalized cells' karyotypes were analyzed at passages 10, 20, 30 and 40 to detect the effects of chromosome stability. Western blotting examined that whether or not the immortalized cells at passages 5, 10, 20, 30, 40 and 50 could induce expression of casein in a 3D culture system. The proper polarization of the acinar structures was monitored. BMECs were successfully immortalized. The cell karyotype at passage 30 remained at 60 chromosomes and the average value was 57.1 ± 0.40 after passage 40. The polarized protein's levels were up-regulated in 3D culture compared to 2D culture. Expression of αs1, β and κ-casein could be detectable in a passage range in 3D culture. Expression of αs2-casein was undetectable in all experimental groups. However, all casein expressions were barely detectable in traditional 2D culture system. Therefore, 3D culture system is an important tool for the long-term study of lactation mechanisms in vitro. © 2016 Japanese Society of Animal Science.

  4. Immortality in Empedocles

    OpenAIRE

    Long, Alex

    2017-01-01

    Most of the work for the paper was undertaken in Toronto during a Leverhulme Research Fellowship. The paper examines Empedocles’ attributions of immortality. I argue that Empedocles does not withhold immortality from the gods but rather has an unorthodox conception of what immortality is. Immortality does not mean, or imply, endless duration. A god’s immortality is its continuity, as one and the same organism, over a long but finite period. This conception of divine immortality then influe...

  5. THE IDEA OF IMMORTALITY IN THE THEOCENTRICAL IDEOLOGICAL SYSTEMS AND IN A RELIGIOUS WORLDVIEW

    Directory of Open Access Journals (Sweden)

    Ekaterina Vadimovna Shiryaeva

    2015-01-01

    Full Text Available The article addresses the idea of human immortality, reflected in different ways in different forms of religious outlook, analyzes cultural, historical and individualpersonal traits of the existence of this idea. It is proved that individual- personal characteristics of the subject of religious consciousness have crucial significance for the predominance of soft or rigid forms of retribution beyond the grave. The article makes comparison of Christianity, Islam and Buddhism and Western and Orthodox versions of immortality within the Christian religion. Detailed attention is paid to the ideas of the immortality in Russian philosophy (the heritage of N.F. Fedorov, N.A.Berdyaev, S.L. Frank, Lev Shestov.It is concluded that the moral reasons for rejecting the death by Russian thinkers are in their special attention to the value of the bodily-spiritual unity of the human personality.It is stated that two main social functions performed by religion as a social institution are repressive and compensatory functions; the latter exist and interact as a dialectical contradiction. The author considers the typical approaches to the problem of death and immortality by Orthodox theologians of the 19th and 20th centuries; it is noted that in their works there is a tendency towards decreasing the repressive component in the models of the underworld retribution. At the same time, the disciplinary function of the official church religiosity is important, as the church retains its influence mainly through the implementation of this function.It is concluded that the perceptions of the human postmortem existence reflect the national-cultural and subjective-personal features of understanding the justice as an ethical category, as well as the fact that the idea of immortality in religious consciousness takes different forms not only in accordance with the type of religion but rather with the type of personal attitude to the problem of death.

  6. Immortality of cancers

    Science.gov (United States)

    Duesberg, Peter; McCormack, Amanda

    2013-01-01

    Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Here we advance a karyotypic theory of immortality based on the theory that carcinogenesis is a form of speciation. Accordingly, cancers are generated from normal cells by random karyotypic rearrangements and selection for cancer-specific reproductive autonomy. Since such rearrangements unbalance long-established mitosis genes, cancer karyotypes vary spontaneously but are stabilized perpetually by clonal selections for autonomy. To test this theory we have analyzed neoplastic clones, presumably immortalized by transfection with overexpressed telomerase or with SV40 tumor virus, for the predicted clonal yet flexible karyotypes. The following results were obtained: (1) All immortal tumorigenic lines from cells transfected with overexpressed telomerase had clonal and flexible karyotypes; (2) Searching for the origin of such karyotypes, we found spontaneously increasing, random aneuploidy in human fibroblasts early after transfection with overexpressed telomerase; (3) Late after transfection, new immortal tumorigenic clones with new clonal and flexible karyotypes were found; (4) Testing immortality of one clone during 848 unselected generations showed the chromosome number was stable, but the copy numbers of 36% of chromosomes drifted ± 1; (5) Independent immortal tumorigenic clones with individual, flexible karyotypes arose after individual latencies; (6) Immortal tumorigenic clones with new flexible karyotypes also arose late from cells of a telomerase-deficient mouse rendered aneuploid by SV40 virus. Because immortality and tumorigenicity: (1) correlated exactly with individual clonal but flexible karyotypes; (2) originated simultaneously with such karyotypes; and (3) arose in the absence of telomerase, we conclude that clonal and flexible karyotypes generate the immortality of cancers. PMID:23388461

  7. Dynamical systems

    CERN Document Server

    Sternberg, Shlomo

    2010-01-01

    Celebrated mathematician Shlomo Sternberg, a pioneer in the field of dynamical systems, created this modern one-semester introduction to the subject for his classes at Harvard University. Its wide-ranging treatment covers one-dimensional dynamics, differential equations, random walks, iterated function systems, symbolic dynamics, and Markov chains. Supplementary materials offer a variety of online components, including PowerPoint lecture slides for professors and MATLAB exercises.""Even though there are many dynamical systems books on the market, this book is bound to become a classic. The the

  8. Immortality of Cu damascene interconnects

    Science.gov (United States)

    Hau-Riege, Stefan P.

    2002-04-01

    We have studied short-line effects in fully-integrated Cu damascene interconnects through electromigration experiments on lines of various lengths and embedded in different dielectric materials. We compare these results with results from analogous experiments on subtractively-etched Al-based interconnects. It is known that Al-based interconnects exhibit three different behaviors, depending on the magnitude of the product of current density, j, and line length, L: For small values of (jL), no void nucleation occurs, and the line is immortal. For intermediate values, voids nucleate, but the line does not fail because the current can flow through the higher-resistivity refractory-metal-based shunt layers. Here, the resistance of the line increases but eventually saturates, and the relative resistance increase is proportional to (jL/B), where B is the effective elastic modulus of the metallization system. For large values of (jL/B), voiding leads to an unacceptably high resistance increase, and the line is considered failed. By contrast, we observed only two regimes for Cu-based interconnects: Either the resistance of the line stays constant during the duration of the experiment, and the line is considered immortal, or the line fails due to an abrupt open-circuit failure. The absence of an intermediate regime in which the resistance saturates is due to the absence of a shunt layer that is able to support a large amount of current once voiding occurs. Since voids nucleate much more easily in Cu- than in Al-based interconnects, a small fraction of short Cu lines fails even at low current densities. It is therefore more appropriate to consider the probability of immortality in the case of Cu rather than assuming a sharp boundary between mortality and immortality. The probability of immortality decreases with increasing amount of material depleted from the cathode, which is proportional to (jL2/B) at steady state. By contrast, the immortality of Al-based interconnects is

  9. System Dynamics

    Science.gov (United States)

    Morecroft, John

    System dynamics is an approach for thinking about and simulating situations and organisations of all kinds and sizes by visualising how the elements fit together, interact and change over time. This chapter, written by John Morecroft, describes modern system dynamics which retains the fundamentals developed in the 1950s by Jay W. Forrester of the MIT Sloan School of Management. It looks at feedback loops and time delays that affect system behaviour in a non-linear way, and illustrates how dynamic behaviour depends upon feedback loop structures. It also recognises improvements as part of the ongoing process of managing a situation in order to achieve goals. Significantly it recognises the importance of context, and practitioner skills. Feedback systems thinking views problems and solutions as being intertwined. The main concepts and tools: feedback structure and behaviour, causal loop diagrams, dynamics, are practically illustrated in a wide variety of contexts from a hot water shower through to a symphony orchestra and the practical application of the approach is described through several real examples of its use for strategic planning and evaluation.

  10. Zeno's Paradox of Immortality.

    Science.gov (United States)

    Olshansky, S Jay; Carnes, Bruce A

    2013-01-01

    Scientists who speculate on the future of human longevity have a broad range of views ranging from the promise of immortality, to radical life extension, to declines in life expectancy. Among those who contend that radical life extension is already here, or on the horizon, or immortality is forthcoming, elements of their reasoning appear surprisingly close, if not identical, to a famous mathematical paradox posed by the ancient Greek mathematician known as Zeno. Here we examine the underlying assumptions behind the views that much longer life expectancies are forthcoming or have already arrived, and place their line of reasoning within the context of a new Zeno paradox described here as The Paradox of Immortality. Copyright © 2012 S. Karger AG, Basel.

  11. Dynamical systems

    CERN Document Server

    Birkhoff, George D

    1927-01-01

    His research in dynamics constitutes the middle period of Birkhoff's scientific career, that of maturity and greatest power. -Yearbook of the American Philosophical Society The author's great book€¦is well known to all, and the diverse active modern developments in mathematics which have been inspired by this volume bear the most eloquent testimony to its quality and influence. -Zentralblatt MATH In 1927, G. D. Birkhoff wrote a remarkable treatise on the theory of dynamical systems that would inspire many later mathematicians to do great work. To a large extent, Birkhoff was writing about his o

  12. Dynamic Logics of Dynamical Systems

    CERN Document Server

    Platzer, André

    2012-01-01

    We survey dynamic logics for specifying and verifying properties of dynamical systems, including hybrid systems, distributed hybrid systems, and stochastic hybrid systems. A dynamic logic is a first-order modal logic with a pair of parametrized modal operators for each dynamical system to express necessary or possible properties of their transition behavior. Due to their full basis of first-order modal logic operators, dynamic logics can express a rich variety of system properties, including safety, controllability, reactivity, liveness, and quantified parametrized properties, even about relations between multiple dynamical systems. In this survey, we focus on some of the representatives of the family of differential dynamic logics, which share the ability to express properties of dynamical systems having continuous dynamics described by various forms of differential equations. We explain the dynamical system models, dynamic logics of dynamical systems, their semantics, their axiomatizations, and proof calcul...

  13. The epigenetics of germ-line immortality: lessons from an elegant model system.

    Science.gov (United States)

    Furuhashi, Hirofumi; Kelly, William G

    2010-08-01

    Epigenetic mechanisms are thought to help regulate the unique transcription program that is established in germ cell development. During the germline cycle of many organisms, the epigenome undergoes waves of extensive resetting events, while a part of epigenetic modification remains faithful to specific loci. Little is known about the mechanisms underlying these events, how loci are selected for, or avoid, reprogramming, or even why these events are required. In particular, although the significance of genomic imprinting phenomena involving DNA methylation in mammals is now well accepted, the role of histone modification as a transgenerational epigenetic mechanism has been the subject of debate. Such epigenetic mechanisms may help regulate transcription programs and/or the pluripotent status conferred on germ cells, and contribute to germ line continuity across generations. Recent studies provide new evidence for heritability of histone modifications through germ line cells and its potential effects on transcription regulation both in the soma and germ line of subsequent generations. Unraveling transgenerational epigenetic mechanisms involving highly conserved histone modifications in elegant model systems will accelerate the generation of new paradigms and inspire research in a wide variety of fields, including basic developmental studies and clinical stem cell research.

  14. Science, self, and immortality.

    Science.gov (United States)

    Haught, John F

    2011-10-01

    The following considers the concept of scientific naturalism in relation to life after death and contrasts three alternative perspectives on immortality of the soul, including naturalistic fatalism, otherworldly optimism, and long-suffering hope. © 2011 New York Academy of Sciences.

  15. Generation and evaluation of a human corneal model cell system for ophthalmologic issues using the HPV16 E6/E7 oncogenes as uniform immortalization platform.

    Science.gov (United States)

    Schulz, Simon; Steinberg, Thorsten; Beck, David; Tomakidi, Pascal; Accardi, Rosita; Tommasino, Massimo; Reinhard, Thomas; Eberwein, Philipp

    2013-01-01

    The present study aimed at employing the human papillomavirus type 16 (HPV16) E6/E7 gene platform, to create a uniform authentic in vitro model cell system of the human cornea for ophthalmologic issues and here especially for prospective biomaterial evaluations for therapeutic regenerative approaches. Therefore, HPV16 E6/E7 genes were employed as uniform platform to immortalize primary human corneal keratinocytes (IHCK), fibroblasts (IHCF), and endothelial (IHCE) cells. qPCR revealed that E6/E7 mRNA transcription persisted at rising passages and FISH detection of the chromosome portfolio 1, 8, 10 and 18 showed fairly the disomic cytogenetic status. Hot spot passages proved oscillation of aneuploidies in the entire passage spectrum under study, while hot spot aneuploidies annotated prevalence for distinct chromosomes. Though IIF revealed general endurance, tissue-innate corneal biomarkers were modulated, i.e. expressed in a temporal-confluence, temporal-spatial or passage-dependent manner. In summary, by the fairly normal chromosomal status, and expression of tissue-innate biomarkers, we created for the first time a uniform authentic in vitro model cell system of the human cornea, by application of the HPV16 E6/E7 immortalization platform only. This system renders a precious tool for prospective iterative in vitro studies on issues such as corneal tissue homeostasis, pharmaceutical generics, and/or evaluation of new biomaterials for clinical corneal applications. Copyright © 2013 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

  16. Probabilistic immortality of Cu damascene interconnects

    Science.gov (United States)

    Hau-Riege, Stefan P.

    2002-02-01

    We have studied electromigration short-line effects in Cu damascene interconnects through experiments on lines of various lengths L, stressed at a variety of current densities j, and embedded in different dielectric materials. We observed two modes of resistance evolution: Either the resistance of the lines remains constant for the duration of the test, so that the lines are considered immortal, or the lines fail due to abrupt open-circuit failure. The resistance was not observed to gradually increase and then saturate, as commonly observed in Al-based interconnects, because the barrier is too thin and resistive to serve as a redundant current path should voiding occur. The critical stress for void nucleation was found to be smaller than 41 MPa, since voiding occurred even under the mildest test conditions of j=2 MA/cm2 and L=10.5 μm at 300 °C. A small fraction of short Cu lines failed even at low current densities, which deems necessary a concept of probabilistic immortality rather than deterministic immortality. Experiments and modeling suggest that the probability of immortality is described by (jL2/B), where B is the effective elastic modulus of the metallization scheme. By contrast, the immortality of Al-based interconnects with shunt layers is described by (jL) if no voids nucleate, and (jL/B) if voids do nucleate. Even though the phenomenology of short-line effects differs for Al- and Cu-based interconnects, the immortality of interconnects of either materials system can be explained by the phenomena of nucleation barriers for void formation and void-growth saturation. The differences are due solely to the absence of a shunt layer and the low critical stress for void nucleation in the case of Cu.

  17. Ageing and immortality.

    Science.gov (United States)

    Rose, M R; Mueller, L D

    2000-01-01

    The concept of the force of natural selection was developed to explain the evolution of ageing. After ageing, however, comes a period in which mortality rates plateau and some individual organisms could, in theory, live forever. This late-life immortality has no presently agreed upon explanation. Two main theories have been offered. The first is heterogeneity within ageing cohorts, such that only extremely robust individuals survive ageing. This theory can be tested by comparisons of more and less robust cohorts. It can also be tested by fitting survival data to its models. The second theory is that late-life plateaus in mortality reflect the inevitable late-life plateau in the force of natural selection. This theory can be tested by changing the force of natural selection in evolving laboratory populations, particularly the age at which the force plateaus. This area of research has great potential for elucidating the overall structure of life-history evolution, particularly the interrelationship between the three life-history phases of development, ageing and immortality. PMID:11127912

  18. The Immortal Fire Within

    Science.gov (United States)

    Sheehan, William

    2007-12-01

    Preface; Key to abbreviations in notes; 1. Through rugged ways; 2. Ardent and faithful work with a telescope; 3. Mars; his moons and his heavens; 4. A seeker of comets; 5. Vanderbilt astronomer; 6. In the realm of the nebulae; 7. Go west, young man!; 8. Hanging fire; 9. On Mt. Hamilton; 10. A year of wonders; 11. The young rebel; 12. 'I am tired here'; 13. Immortality; 14. Travels and travails; 15. Barnard and Mars; 16. Nature's true artisan; 17. A tide in his affairs; 18. Yerkes observatory; 19. Disappointments and triumphs; 20. The comet and Milky Way photographs; 21. Comet tales; 22. Observer of all that shines - or obscures; 23. Eclipse and decline; 24. Ad astra; Index.

  19. Dynamical system synchronization

    CERN Document Server

    Luo, Albert C J

    2013-01-01

    Dynamical System Synchronization (DSS) meticulously presents for the first time the theory of dynamical systems synchronization based on the local singularity theory of discontinuous dynamical systems. The book details the sufficient and necessary conditions for dynamical systems synchronizations, through extensive mathematical expression. Techniques for engineering implementation of DSS are clearly presented compared with the existing techniques.  This book also:  Presents novel concepts and methods for dynamical system synchronization Extends beyond the Lyapunov theory for dynamical system synchronization Introduces companion and synchronization of discrete dynamical systems Includes local singularity theory for discontinuous dynamical systems Covers the invariant domains of synchronization Features more than 75 illustrations Dynamical System Synchronization is an ideal book for those interested in better understanding new concepts and methodology for dynamical system synchronization, local singularity...

  20. for hybrid dynamical systems

    Directory of Open Access Journals (Sweden)

    Wassim M. Haddad

    2001-01-01

    Full Text Available In this paper we develop a unified dynamical systems framework for a general class of systems possessing left-continuous flows; that is, left-continuous dynamical systems. These systems are shown to generalize virtually all existing notions of dynamical systems and include hybrid, impulsive, and switching dynamical systems as special cases. Furthermore, we generalize dissipativity, passivity, and nonexpansivity theory to left-continuous dynamical systems. Specifically, the classical concepts of system storage functions and supply rates are extended to left-continuous dynamical systems providing a generalized hybrid system energy interpretation in terms of stored energy, dissipated energy over the continuous-time dynamics, and dissipated energy over the resetting events. Finally, the generalized dissipativity notions are used to develop general stability criteria for feedback interconnections of left-continuous dynamical systems. These results generalize the positivity and small gain theorems to the case of left-continuous, hybrid, and impulsive dynamical systems.

  1. An In Vitro System Comprising Immortalized Hypothalamic Neuronal Cells (GT1–7 Cells for Evaluation of the Neuroendocrine Effects of Essential Oils

    Directory of Open Access Journals (Sweden)

    Dai Mizuno

    2015-01-01

    Full Text Available Aromatherapy and plant-based essential oils are widely used as complementary and alternative therapies for symptoms including anxiety. Furthermore, it was reportedly effective for the care of several diseases such as Alzheimer’s disease and depressive illness. To investigate the pharmacological effects of essential oils, we developed an in vitro assay system using immortalized hypothalamic neuronal cells (GT1–7 cells. In this study, we evaluated the effects of essential oils on neuronal death induced by hydrogen peroxide (H2O2, aluminum, zinc, or the antagonist of estrogen receptor (tamoxifen. Among tests of various essential oils, we found that H2O2-induced neuronal death was attenuated by the essential oils of damask rose, eucalyptus, fennel, geranium, ginger, kabosu, mandarin, myrrh, and neroli. Damask rose oil had protective effects against aluminum-induced neurotoxicity, while geranium and rosemary oil showed protective activity against zinc-induced neurotoxicity. In contrast, geranium oil and ginger oil enhanced the neurotoxicity of tamoxifen. Our in vitro assay system could be useful for the neuropharmacological and endocrine pharmacological studies of essential oils.

  2. The illusion of cell immortality

    Science.gov (United States)

    Hayflick, L

    2000-01-01

    Normal cultured cell populations are mortal but cells that are immortal are abnormal and most have properties of cancer cells. Nevertheless, this distinction becomes blurred because the terms ‘mortality’ and ‘immortality’ are subject to enormous variations in understanding. Forty years ago we showed that cell mortality and immortality are inextricably linked to longevity determination, ageing and cancer. We suggested that a counting mechanism existed in normal cells and that has now been identified as telomere attrition. This replicometer, in combination with the discovery of the enzyme telomerase, has gone very far in explaining why most normal somatic cells have a finite capacity to replicate both in vivo and in vitro and how immortal cancer cells circumvent this inevitability. It is suggested that telomere attrition may be better understood as a direct measure of longevity determination and to only have an indirect association with age changes. © 2000 Cancer Research Campaign PMID:10970682

  3. Dynamic Interactive Learning Systems

    Science.gov (United States)

    Sabry, Khaled; Barker, Jeff

    2009-01-01

    This paper reviews and discusses the notions of interactivity and dynamicity of learning systems in relation to information technologies and design principles that can contribute to interactive and dynamic learning. It explores the concept of dynamic interactive learning systems based on the emerging generation of information as part of a…

  4. Dynamical Systems Conference

    CERN Document Server

    Gils, S; Hoveijn, I; Takens, F; Nonlinear Dynamical Systems and Chaos

    1996-01-01

    Symmetries in dynamical systems, "KAM theory and other perturbation theories", "Infinite dimensional systems", "Time series analysis" and "Numerical continuation and bifurcation analysis" were the main topics of the December 1995 Dynamical Systems Conference held in Groningen in honour of Johann Bernoulli. They now form the core of this work which seeks to present the state of the art in various branches of the theory of dynamical systems. A number of articles have a survey character whereas others deal with recent results in current research. It contains interesting material for all members of the dynamical systems community, ranging from geometric and analytic aspects from a mathematical point of view to applications in various sciences.

  5. Disruptive chemicals, senescence and immortality.

    Science.gov (United States)

    Carnero, Amancio; Blanco-Aparicio, Carmen; Kondoh, Hiroshi; Lleonart, Matilde E; Martinez-Leal, Juan Fernando; Mondello, Chiara; Scovassi, A Ivana; Bisson, William H; Amedei, Amedeo; Roy, Rabindra; Woodrick, Jordan; Colacci, Annamaria; Vaccari, Monica; Raju, Jayadev; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Salem, Hosni K; Memeo, Lorenzo; Forte, Stefano; Singh, Neetu; Hamid, Roslida A; Ryan, Elizabeth P; Brown, Dustin G; Wise, John Pierce; Wise, Sandra S; Yasaei, Hemad

    2015-06-01

    Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of 'driver mutations' enabling a selective advantage in a particular micro-environment. Clonal selection is the driving force behind tumorigenesis and possesses three basic requirements: (i) effective competitive proliferation of the variant clone when compared with its neighboring cells, (ii) acquisition of an indefinite capacity for self-renewal, and (iii) establishment of sufficiently high levels of genetic and epigenetic variability to permit the emergence of rare variants. However, several questions regarding the process of clonal evolution remain. Which cellular processes initiate carcinogenesis in the first place? To what extent are environmental carcinogens responsible for the initiation of clonal evolution? What are the roles of genotoxic and non-genotoxic carcinogens in carcinogenesis? What are the underlying mechanisms responsible for chemical carcinogen-induced cellular immortality? Here, we explore the possible mechanisms of cellular immortalization, the contribution of immortalization to tumorigenesis and the mechanisms by which chemical carcinogens may contribute to these processes. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. Bisimulation of Dynamical Systems

    NARCIS (Netherlands)

    Schaft, Arjan van der

    2004-01-01

    A general notion of bisimulation is studied for dynamical systems. An algebraic characterization of bisimulation together with an algorithm for computing the maximal bisimulation relation is derived using geometric control theory. Bisimulation of dynamical systems is shown to be a concept which

  7. Transplantation of Immortalized CD34+ and CD34- Adipose-Derived Stem Cells Improve Cardiac Function and Mitigate Systemic Pro-Inflammatory Responses.

    Directory of Open Access Journals (Sweden)

    Jong-Ho Kim

    Full Text Available Adipose-derived stem cells (ADSCs have the potential to differentiate into various cell lineages and they are easily obtainable from patients, which makes them a promising candidate for cell therapy. However, a drawback is their limited life span during in vitro culture. Therefore, hTERT-immortalized CD34+ and CD34- mouse ADSC lines (mADSCshTERT tagged with GFP were established. We evaluated the proliferation capacity, multi-differentiation potential, and secretory profiles of CD34+ and CD34- mADSCshTERT in vitro, as well as their effects on cardiac function and systemic inflammation following transplantation into a rat model of acute myocardial infarction (AMI to assess whether these cells could be used as a novel cell source for regeneration therapy in the cardiovascular field. CD34+ and CD34- mADSCshTERT demonstrated phenotypic characteristics and multi-differentiation potentials similar to those of primary mADSCs. CD34+ mADSCshTERT exhibited a higher proliferation ability compared to CD34- mADSCshTERT, whereas CD34- mADSCshTERT showed a higher osteogenic differentiation potential compared to CD34+ mADSCshTERT. Primary mADSCs, CD34+, and CD34- mADSCshTERT primarily secreted EGF, TGF-β1, IGF-1, IGF-2, MCP-1, and HGFR. CD34+ mADSCshTERT had higher secretion of VEGF and SDF-1 compared to CD34- mADSCshTERT. IL-6 secretion was severely reduced in both CD34+ and CD34- mADSCshTERT compared to primary mADSCs. Transplantation of CD34+ and CD34- mADSCshTERT significantly improved the left ventricular ejection fraction and reduced infarct size compared to AMI-induced rats after 28 days. At 28 days after transplantation, engraftment of CD34+ and CD34- mADSCshTERT was confirmed by positive Y chromosome staining, and differentiation of CD34+ and CD34- mADSCshTERT into endothelial cells was found in the infarcted myocardium. Significant decreases were observed in circulating IL-6 levels in CD34+ and CD34- mADSCshTERT groups compared to the AMI

  8. Stability of dynamical systems

    CERN Document Server

    Liao, Xiaoxin; Yu, P 0

    2007-01-01

    The main purpose of developing stability theory is to examine dynamic responses of a system to disturbances as the time approaches infinity. It has been and still is the object of intense investigations due to its intrinsic interest and its relevance to all practical systems in engineering, finance, natural science and social science. This monograph provides some state-of-the-art expositions of major advances in fundamental stability theories and methods for dynamic systems of ODE and DDE types and in limit cycle, normal form and Hopf bifurcation control of nonlinear dynamic systems.ʺ Presents

  9. Does 'Immortal DNA strand' exist in 'immortal' stem cells?

    Institute of Scientific and Technical Information of China (English)

    Linheng Li

    2007-01-01

    @@ Stem cells function to generate differentiated cells,and,at the same time,are maintained as‘immortal'cells through self-renewal.Accumulated evidence indicates that adult stem cells may be the most common precursor for cancers in adult mammalian tissue[1],and this concept is gaining increasing support[2,3].Meanwhile,this also raises the question of how stem cells,which have a much longer lifespan compared to other progenitor and mature ceils,can avoid accumulating mutations from DNA replica-tion errors.

  10. Natural selection and immortality.

    Science.gov (United States)

    Danchin, Antoine

    2009-08-01

    Genomes replicate while the host cells reproduce. I explore the reproduction/replication dialogue, based on a deep analysis of bacterial genomes, in relation to ageing. Making young structures from aged ones implies creating information. I revisit Information Theory, showing that the laws of physics permit de novo creation of information, provided an energy-dependent process preserving functional entities makes room for entities accumulating information. I identify explicit functions involved in the process and characterise some of their genes. I suggest that the energy source necessary to establish reproduction while replication is temporarily stopped could be the ubiquitous polyphosphates. Finally, I show that rather than maintain and repair the original individual, organisms tend to metamorphose into young ones, sometimes totally, sometimes progressively. This permits living systems to accumulate information over generations, but has the drawback, in multicellular organisms, to open the door for immortalisation, leading to cancer.

  11. Shadowing in dynamical systems

    CERN Document Server

    Pilyugin, Sergei Yu

    1999-01-01

    This book is an introduction to the theory of shadowing of approximate trajectories in dynamical systems by exact ones. This is the first book completely devoted to the theory of shadowing. It shows the importance of shadowing theory for both the qualitative theory of dynamical systems and the theory of numerical methods. Shadowing Methods allow us to estimate differences between exact and approximate solutions on infinite time intervals and to understand the influence of error terms. The book is intended for specialists in dynamical systems, for researchers and graduate students in the theory of numerical methods.

  12. Fractional Dynamical Systems

    CERN Document Server

    Edelman, Mark

    2014-01-01

    In this paper the author presents the results of the preliminary investigation of fractional dynamical systems based on the results of numerical simulations of fractional maps. Fractional maps are equivalent to fractional differential equations describing systems experiencing periodic kicks. Their properties depend on the value of two parameters: the non-linearity parameter, which arises from the corresponding regular dynamical systems; and the memory parameter which is the order of the fractional derivative in the corresponding non-linear fractional differential equations. The examples of the fractional Standard and Logistic maps demonstrate that phase space of non-linear fractional dynamical systems may contain periodic sinks, attracting slow diverging trajectories, attracting accelerator mode trajectories, chaotic attractors, and cascade of bifurcations type trajectories whose properties are different from properties of attractors in regular dynamical systems. The author argues that discovered properties s...

  13. Progressive transformation of immortalized esophageal epithelial cells

    Institute of Scientific and Technical Information of China (English)

    Zhong-Ying Shen; Li-Yan Xu; Min-Hua Chen; Jian Shen; Wei-Jia Cai; Yi Zeng

    2002-01-01

    .CONCLUSION: In continual cultivation of fetal esophageal epithelial cells with transduction of HPV18E6E7, cells from the 10th to the 85th passage were changed gradually from preimmortal, immortal, precancerous to malignantly transformed stages. All of these changes were in a dynamic progressive process. The establishment of a continuous line of esophageal epithelium may provide a in vitro model of carcinogenesis induced by HPV.

  14. Invitation to dynamical systems

    CERN Document Server

    Scheinerman, Edward R

    2012-01-01

    This text is designed for those who wish to study mathematics beyond linear algebra but are unready for abstract material. Rather than a theorem-proof-corollary exposition, it stresses geometry, intuition, and dynamical systems. 1996 edition.

  15. ON PERIODIC DYNAMICAL SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    LU WENLIAN; CHEN TIANPING

    2004-01-01

    The authors investigate the existence and the global stability of periodic solution for dynamical systems with periodic interconnections, inputs and self-inhibitions. The model is very general, the conditions are quite weak and the results obtained are universal.

  16. Dynamic performance management system

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    An integrated, efficient and effective performance management system, "dynamic performance management system", is presented, which covers the entire performance management process including measures design, analysis, and dynamic update. The analysis of performance measures using causal loop diagrams, qualitative inference and analytic network process is mainly discussed. A real world case study is carried out throughout the paper to explain how the framework works. A software tool for DPMS, Performance Analyzer, is also introduced.

  17. Strategies for immortalization of primary hepatocytes

    Science.gov (United States)

    Eva, Ramboer; Bram, De Craene; Joery, De Kock; Tamara, Vanhaecke; Geert, Berx; Vera, Rogiers; Mathieu, Vinken

    2014-01-01

    The liver has the unique capacity to regenerate in response to a damaging event. Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte cell cycle is a complex process that is tightly regulated by several well-established mechanisms. In vitro, isolated hepatocytes do not longer retain this proliferative capacity. However, in vitro cell growth can be boosted by immortalization of hepatocytes. Well-defined immortalization genes can be artificially overexpressed in hepatocytes or the cells can be conditionally immortalized leading to controlled cell proliferation. This paper discusses the current immortalization techniques and provides a state-of-the-art overview of the actually available immortalized hepatocyte-derived cell lines and their applications. PMID:24911463

  18. Dynamics of Information Systems

    CERN Document Server

    Hirsch, Michael J; Murphey, Robert

    2010-01-01

    Our understanding of information and information dynamics has outgrown classical information theory. This book presents the research explaining the importance of information in the evolution of a distributed or networked system. It presents techniques for measuring the value or significance of information within the context of a system

  19. Dynamic Systems Modeling

    Directory of Open Access Journals (Sweden)

    Sorin Dan ŞANDOR

    2003-01-01

    Full Text Available System Dynamics was introduced by Jay W. Forrester in the 1960s. Since then the methodology was adopted in many areas of natural or social sciences. This article tries to present briefly how this methodology works, both as Systems Thinking and as Modelling with Vensim computer software.

  20. Semipredictable dynamical systems

    Science.gov (United States)

    García-Morales, Vladimir

    2016-10-01

    A new class of deterministic dynamical systems, termed semipredictable dynamical systems, is presented. The spatiotemporal evolution of these systems have both predictable and unpredictable traits, as found in natural complex systems. We prove a general result: The dynamics of any deterministic nonlinear cellular automaton (CA) with p possible dynamical states can be decomposed at each instant of time in a superposition of N layers involving p0, p1, …, pN - 1 dynamical states each, where the pk ∈ N , k ∈ [ 0 , N - 1 ] are divisors of p. If the divisors coincide with the prime factors of p this decomposition is unique. Conversely, we also prove that N CA working on symbols p0, p1, …, pN - 1 can be composed to create a graded CA rule with N different layers. We then show that, even when the full spatiotemporal evolution can be unpredictable, certain traits (layers) can exactly be predicted. We present explicit examples of such systems involving compositions of Wolfram's 256 elementary CA and a more complex CA rule acting on a neighborhood of two sites and 12 symbols and whose rule table corresponds to the smallest Moufang loop M12(S3, 2).

  1. Dynamic system classifier

    CERN Document Server

    Pumpe, Daniel; Müller, Ewald; Enßlin, Torsten A

    2016-01-01

    Stochastic differential equations describe well many physical, biological and sociological systems, despite the simplification often made in their derivation. Here the usage of simple stochastic differential equations to characterize and classify complex dynamical systems is proposed within a Bayesian framework. To this end, we develop a dynamic system classifier (DSC). The DSC first abstracts training data of a system in terms of time dependent coefficients of the descriptive stochastic differential equation. Thereby the DSC identifies unique correlation structures within the training data. For definiteness we restrict the presentation of DSC to oscillation processes with a time dependent frequency {\\omega}(t) and damping factor {\\gamma}(t). Although real systems might be more complex, this simple oscillator captures many characteristic features. The {\\omega} and {\\gamma} timelines represent the abstract system characterization and permit the construction of efficient signal classifiers. Numerical experiment...

  2. Dynamic system classifier

    Science.gov (United States)

    Pumpe, Daniel; Greiner, Maksim; Müller, Ewald; Enßlin, Torsten A.

    2016-07-01

    Stochastic differential equations describe well many physical, biological, and sociological systems, despite the simplification often made in their derivation. Here the usage of simple stochastic differential equations to characterize and classify complex dynamical systems is proposed within a Bayesian framework. To this end, we develop a dynamic system classifier (DSC). The DSC first abstracts training data of a system in terms of time-dependent coefficients of the descriptive stochastic differential equation. Thereby the DSC identifies unique correlation structures within the training data. For definiteness we restrict the presentation of the DSC to oscillation processes with a time-dependent frequency ω (t ) and damping factor γ (t ) . Although real systems might be more complex, this simple oscillator captures many characteristic features. The ω and γ time lines represent the abstract system characterization and permit the construction of efficient signal classifiers. Numerical experiments show that such classifiers perform well even in the low signal-to-noise regime.

  3. Complexity in Dynamical Systems

    Science.gov (United States)

    Moore, Cristopher David

    The study of chaos has shown us that deterministic systems can have a kind of unpredictability, based on a limited knowledge of their initial conditions; after a finite time, the motion appears essentially random. This observation has inspired a general interest in the subject of unpredictability, and more generally, complexity; how can we characterize how "complex" a dynamical system is?. In this thesis, we attempt to answer this question with a paradigm of complexity that comes from computer science, we extract sets of symbol sequences, or languages, from a dynamical system using standard methods of symbolic dynamics; we then ask what kinds of grammars or automata are needed a generate these languages. This places them in the Chomsky heirarchy, which in turn tells us something about how subtle and complex the dynamical system's behavior is. This gives us insight into the question of unpredictability, since these automata can also be thought of as computers attempting to predict the system. In the culmination of the thesis, we find a class of smooth, two-dimensional maps which are equivalent to the highest class in the Chomsky heirarchy, the turning machine; they are capable of universal computation. Therefore, these systems possess a kind of unpredictability qualitatively different from the usual "chaos": even if the initial conditions are known exactly, questions about the system's long-term dynamics are undecidable. No algorithm exists to answer them. Although this kind of unpredictability has been discussed in the context of distributed, many-degree-of -freedom systems (for instance, cellular automata) we believe this is the first example of such phenomena in a smooth, finite-degree-of-freedom system.

  4. Staphylococcal superantigens stimulate immortalized human adipocytes to produce chemokines.

    Directory of Open Access Journals (Sweden)

    Bao G Vu

    Full Text Available BACKGROUND: Human adipocytes may have significant functions in wound healing and the development of diabetes through production of pro-inflammatory cytokines after stimulation by gram-negative bacterial endotoxin. Diabetic foot ulcers are most often associated with staphylococcal infections. Adipocyte responses in the area of the wound may play a role in persistence and pathology. We studied the effect of staphylococcal superantigens (SAgs on immortalized human adipocytes, alone and in the presence of bacterial endotoxin or staphylococcal α-toxin. METHODOLOGY/PRINCIPAL FINDINGS: Primary non-diabetic and diabetic human preadipocytes were immortalized by the reverse transcriptase component of telomerase (TERT and the E6/E7 genes of human papillomavirus. The immortal cells were demonstrated to have properties of non-immortalized pre-adipocytes and could be differentiated into mature and functional adipocytes. Differentiated adipocytes exposed to staphylococcal SAgs produced robust levels of cytokines IL-6 and IL-8, but there were no significant differences in levels between the non-diabetic and diabetic cells. Cytokine production was increased by co-incubation of adipocytes with SAgs and endotoxin together. In contrast, α-toxin alone was cytotoxic at high concentrations, but, at sub-cytotoxic doses, did not stimulate production of IL-6 and IL-8. CONCLUSIONS/SIGNIFICANCE: Endotoxin has been proposed to contribute to diabetes through enhanced insulin resistance after chronic exposure and stimulation of adipocytes to produce cytokines. Our data indicate staphylococcal SAgs TSST-1 and SEB alone and in combination with bacterial endotoxin also stimulate adipocytes to produce cytokines and thus may contribute to the inflammatory response found in chronic diabetic ulcers and in the systemic inflammation that is associated with the development and persistence of diabetes. The immortal human pre-adipocytes reported here will be useful for studies to

  5. Universal mortality law and immortality

    Science.gov (United States)

    Azbel', Mark Ya.

    2004-10-01

    Well-protected human and laboratory animal populations with abundant resources are evolutionarily unprecedented. Physical approach, which takes advantage of their extensively quantified mortality, establishes that its dominant fraction yields the exact law, which is universal for all animals from yeast to humans. Singularities of the law demonstrate new kinds of stepwise adaptation. The law proves that universal mortality is an evolutionary by-product, which at any given age is reversible, independent of previous life history, and disposable. Life expectancy may be extended, arguably to immortality, by minor biological amendments in the animals. Indeed, in nematodes with a small number of perturbed genes and tissues it increased 6-fold (to 430 years in human terms), with no apparent loss in health and vitality. The law relates universal mortality to specific processes in cells and their genetic regulation.

  6. Complexified dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    Bender, Carl M [Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Holm, Darryl D [Department of Mathematics, Imperial College, London SW7 2AZ (United Kingdom); Hook, Daniel W [Blackest Laboratory, Imperial College, London SW7 2BZ (United Kingdom)

    2007-08-10

    Many dynamical systems, such as the Lotka-Volterra predator-prey model and the Euler equations for the free rotation of a rigid body, are PT symmetric. The standard and well-known real solutions to such dynamical systems constitute an infinitessimal subclass of the full set of complex solutions. This paper examines a subset of the complex solutions that contains the real solutions, namely those having PT symmetry. The condition of PT symmetry selects out complex solutions that are periodic. (fast track communication)

  7. Establishment and culture optimization of a new type of pituitary immortalized cell line

    Energy Technology Data Exchange (ETDEWEB)

    Kokubu, Yuko [Graduate School of Life and Environmental Sciences, The University of Tsukuba, Tsukuba, Ibaraki 305-8562 (Japan); Asashima, Makoto [Graduate School of Life and Environmental Sciences, The University of Tsukuba, Tsukuba, Ibaraki 305-8562 (Japan); Life Science Center of TARA, The University of Tsukuba, Ibaraki-ken 305-8577 (Japan); Kurisaki, Akira, E-mail: akikuri@hotmail.com [Graduate School of Life and Environmental Sciences, The University of Tsukuba, Tsukuba, Ibaraki 305-8562 (Japan); Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562 (Japan)

    2015-08-07

    The pituitary gland is a center of the endocrine system that controls homeostasis in an organism by secreting various hormones. The glandular anterior pituitary consists of five different cell types, each expressing specific hormones. However, their regulation and the appropriate conditions for their in vitro culture are not well defined. Here, we report the immortalization of mouse pituitary cells by introducing TERT, E6, and E7 transgenes. The immortalized cell lines mainly expressed a thyrotroph-specific thyroid stimulating hormone beta (Tshb). After optimization of the culture conditions, these immortalized cells proliferated and maintained morphological characteristics similar to those of primary pituitary cells under sphere culture conditions in DMEM/F12 medium supplemented with N2, B27, basic FGF, and EGF. These cell lines responded to PKA or PKC pathway activators and induced the expression of Tshb mRNA. Moreover, transplantation of the immortalized cell line into subcutaneous regions and kidney capsules of mice further increased Tshb expression. These results suggest that immortalization of pituitary cells with TERT, E6, and E7 transgenes is a useful method for generating proliferating cells for the in vitro analysis of pituitary regulatory mechanisms. - Highlights: • Mouse pituitary cell lines were immortalized by introducing TERT, E6, and E7. • The immortalized cell lines mainly expressed thyroid stimulating hormone beta. • The cell lines responded to PKA or PKC pathway activators, and induced Tshb.

  8. Altered chromosome 6 in immortal human fibroblasts.

    Science.gov (United States)

    Hubbard-Smith, K; Patsalis, P; Pardinas, J R; Jha, K K; Henderson, A S; Ozer, H L

    1992-05-01

    Human diploid fibroblasts have a limited life span in vitro, and spontaneous immortalization is an extremely rare event. We have used transformation of human diploid fibroblasts by an origin-defective simian virus 40 genome to develop series of genetically matched immortal cell lines to analyze immortalization. Comparison of a preimmortal transformant (SVtsA/HF-A) with its uncloned and cloned immortalized derivatives (AR5 and HAL) has failed to reveal any major alteration involving the simian virus 40 genome. Karyotypic analysis, however, demonstrated that all of the immortal cell lines in this series have alterations of chromosome 6 involving loss of the portion distal to 6q21. The karyotypic analysis was corroborated by DNA analyses. Southern analysis demonstrated that only one copy of three proto-oncogene loci (ros1, c-myb, and mas1) on 6q was retained in immortal cells. Polymerase chain reaction analysis of the microsatellite polymorphism at 6q22 (D6S87) showed loss of heterozygosity. In addition, elevated expression of c-myb (6q22-23) was observed. We hypothesize that the region at and/or distal to 6q21 plays a role in immortalization, consistent with the presence of a growth suppressor gene.

  9. Altered chromosome 6 in immortal human fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard-Smith, K.; Pardinas, J.R.; Jha, K.K.; Ozer, H.L. (New Jersey Medical School, Newark, NJ (United States)); Patsalis, P.; Henderson, A.S. (City Univ. of New York, NY (United States))

    1992-05-01

    Human diploid fibroblasts have a limited life span in vitro, and spontaneous immortalization is an extremely rare event. We have used transformation of human diploid fibroblasts by an origin-defective simian virus 40 genome to develop series of genetically matched immortal cell lines to analyze immortalization. Comparison of a preimmortal transformant (SVtsA/HF-A) with its uncloned and cloned immortalized derivatives (AR5 and HAL) has failed to reveal any major alteration involving the simian virus 40 genome. Karyotypic analysis, however, demonstrated that all of the immortal cell lines in this series have alterations of chromosome 6 involving loss of the portion distal to 6q21. The karyotypic analysis was corroborated by DNA analyses. Southern analysis demonstrated that only one copy of three proto-oncogene loci (ros1, c-myb, and mas1) on 6q was retained in immortal cells. Polymerase chain reaction analysis of the microsatellite polymorphism at 6q22 (D6S87) showed loss of heterozygosity. In addition, elevated expression of c-myb (6q22-23) was observed. We hypothesize that the region at and/or distal to 6q21 plays a role in immortalization, consistent with the presence of a growth suppressor gene. 66 refs., 6 figs., 2 tabs.

  10. System dynamics with interaction discontinuity

    CERN Document Server

    Luo, Albert C J

    2015-01-01

    This book describes system dynamics with discontinuity caused by system interactions and presents the theory of flow singularity and switchability at the boundary in discontinuous dynamical systems. Based on such a theory, the authors address dynamics and motion mechanism of engineering discontinuous systems due to interaction. Stability and bifurcations of fixed points in nonlinear discrete dynamical systems are presented, and mapping dynamics are developed for analytical predictions of periodic motions in engineering discontinuous dynamical systems. Ultimately, the book provides an alternative way to discuss the periodic and chaotic behaviors in discontinuous dynamical systems.

  11. Immortalization of Werner syndrome and progeria fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Saito, H.; Moses, R.E. (Baylor College of Medicine, Houston, TX (USA))

    1991-02-01

    Human fibroblast cells from two different progeroid syndromes, Werner syndrome (WS) and progeria, were established as immortalized cell lines by transfection with plasmid DNA containing the SV40 early region. The lineage of each immortalized cell line was confirmed by VNTR analysis. Each of the immortalized cell lines maintained its original phenotype of slow growth. DNA repair ability of these cells was also studied by measuring sensitivity to killing by uv or the DNA-damaging drugs methyl methansulfonate, bleomycin, and cis-dichlorodiamine platinum. The results showed that both WS and progeria cells have normal sensitivity to these agents.

  12. Maintenance of telomeres in SV40-transformed pre-immortal and immortal human fibroblasts.

    Science.gov (United States)

    Small, M B; Hubbard, K; Pardinas, J R; Marcus, A M; Dhanaraj, S N; Sethi, K A

    1996-09-01

    Shortening of telomeres has been hypothesized to contribute to cellular senescence and may play a role in carcinogenesis of human cells. Furthermore, activation of telomerase has frequently been demonstrated in tumor-derived and in vitro immortalized cells. In this study, we have assessed these phenomena during the life span of simian virus 40 (SV40)-transformed preimmortal and immortal human fibroblasts. We observed progressive reduction in telomere length in preimmortal transformed cells with extended proliferative capacity, with the most dramatic shortening at late passage. Telomere lengths became stabilized (or increased) in immortal fibroblasts accompanied, in one case, by the activation of telomerase. However, an independent immortal cell line that displayed stable telomeres did not have detectable telomerase activity. Furthermore, we found significant telomerase activity in two preimmortal derivatives. Our results provide further evidence for maintenance of telomeres in immortalized human fibroblasts, but they suggest a lack of causal relationship between telomerase activation and immortalization.

  13. "Tuck Everlasting": Winnie Foster's Intimations of Immortality.

    Science.gov (United States)

    Berger, Peter N.

    1998-01-01

    Tells the plot of the novel "Tuck Everlasting" by Natalie Babbitt--the Tucks are invulnerable and immortal, but everlasting life holds trials for them. Provides seven questions for stimulating student response to the novel. (PA)

  14. "Tuck Everlasting": Winnie Foster's Intimations of Immortality.

    Science.gov (United States)

    Berger, Peter N.

    1998-01-01

    Tells the plot of the novel "Tuck Everlasting" by Natalie Babbitt--the Tucks are invulnerable and immortal, but everlasting life holds trials for them. Provides seven questions for stimulating student response to the novel. (PA)

  15. Multistability in dynamical systems

    CERN Document Server

    Mendes, R V

    1999-01-01

    In neuroscience, optics and condensed matter there is ample physical evidence for multistable dynamical systems, that is, systems with a large number of attractors. The known mathematical mechanisms that lead to multiple attractors are homoclinic tangencies and stabilization, by small perturbations or by coupling, of systems possessing a large number of unstable invariant sets. A short review of the existent results is presented, as well as two new results concerning the existence of a large number of stable periodic orbits in a perturbed marginally stable dissipative map and an infinite number of such orbits in two coupled quadratic maps working on the Feigenbaum accumulation point.

  16. Interactive Dynamic-System Simulation

    CERN Document Server

    Korn, Granino A

    2010-01-01

    Showing you how to use personal computers for modeling and simulation, Interactive Dynamic-System Simulation, Second Edition provides a practical tutorial on interactive dynamic-system modeling and simulation. It discusses how to effectively simulate dynamical systems, such as aerospace vehicles, power plants, chemical processes, control systems, and physiological systems. Written by a pioneer in simulation, the book introduces dynamic-system models and explains how software for solving differential equations works. After demonstrating real simulation programs with simple examples, the author

  17. Stationary dynamical systems

    CERN Document Server

    Furstenberg, Hillel

    2009-01-01

    Following works of Furstenberg and Nevo and Zimmer we present an outline of a theory of stationary (or m-stationary) dynamical systems for a general acting group G equipped with a probability measure m. Our purpose is two-fold: First to suggest a more abstract line of development, including a simple structure theory. Second, to point out some interesting applications; one of these is a Szemeredi type theorem for SL(2,R).

  18. The immortality of humoral immunity.

    Science.gov (United States)

    Elgueta, Raul; de Vries, Victor C; Noelle, Randolph J

    2010-07-01

    Decades of high-titered antibody are sustained due to the persistence of memory B cells and long-lived plasma cells (PCs). The differentiation of each of these subsets is antigen- and T-cell driven and is dependent on signals acquired and integrated during the germinal center response. Inherent in the primary immune response must be the delivery of signals to B cells to create these populations, which have virtual immortality. Differences in biology and chemotactic behavior disperse memory B cells and long-lived PCs to a spectrum of anatomic sites. Each subset must rely on survival factors that can support their longevity. This review focuses on the generation of each of these subsets, their survival, and renewal, which must occur to sustain serological memory. In this context, we discuss the role of antigen, bystander inflammation, and cellular niches. The contribution of BAFF (B-cell activating factor belonging to the tumor necrosis factor family) and APRIL (a proliferation-inducing ligand) to the persistence of memory B cells and PCs are also detailed. Insights that have been provided over the past few years in the regulation of long-lived B-cell responses will have profound impact on vaccine development, the treatment of pre-sensitized patients for organ transplantation, and therapeutic interventions in both antibody- and T-cell-mediated autoimmunity.

  19. Dynamical systems theory for music dynamics

    CERN Document Server

    Boon, J P

    1994-01-01

    Abstract:We show that, when music pieces are cast in the form of time series of pitch variations, the concepts and tools of dynamical systems theory can be applied to the analysis of {\\it temporal dynamics} in music. (i) Phase space portraits are constructed from the time series wherefrom the dimensionality is evaluated as a measure of the {\\pit global} dynamics of each piece. (ii) Spectral analysis of the time series yields power spectra (\\sim f^{-\

  20. Butschli Dynamic Droplet System

    DEFF Research Database (Denmark)

    Armstrong, R.; Hanczyc, M.

    2013-01-01

    of a technology with living properties. Otto Butschli first described the system in 1898, when he used alkaline water droplets in olive oil to initiate a saponification reaction. This simple recipe produced structures that moved and exhibited characteristics that resembled, at least superficially, the amoeba. We......Dynamical oil-water systems such as droplets display lifelike properties and may lend themselves to chemical programming to perform useful work, specifically with respect to the built environment. We present Butschli water-in-oil droplets as a model for further investigation into the development...... to the oil phase), qualify this system as an example of living technology. The analysis of the Butschli droplets suggests that a set of conditions may precede the emergence of lifelike characteristics and exemplifies the richness of this rudimentary chemical system, not only for artificial life...

  1. Near periodicity in dynamical systems

    Institute of Scientific and Technical Information of China (English)

    陈文成

    1995-01-01

    The notion of near periodicity is shown to be equivalent to that of weak near periodicity in dynamical systems. A sufficient condition for the positive near periodicity of a point in dynamical systems is given. The structure of nearly periodic dynamical systems is discussed, and a condition is proved to be necessary and sufficient for a dynamical system on a local compact space to be positively nearly periodic.

  2. Therapeutic targeting of replicative immortality.

    Science.gov (United States)

    Yaswen, Paul; MacKenzie, Karen L; Keith, W Nicol; Hentosh, Patricia; Rodier, Francis; Zhu, Jiyue; Firestone, Gary L; Matheu, Ander; Carnero, Amancio; Bilsland, Alan; Sundin, Tabetha; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G; Amedei, Amedeo; Amin, Amr; Helferich, Bill; Boosani, Chandra S; Guha, Gunjan; Ciriolo, Maria Rosa; Chen, Sophie; Mohammed, Sulma I; Azmi, Asfar S; Bhakta, Dipita; Halicka, Dorota; Niccolai, Elena; Aquilano, Katia; Ashraf, S Salman; Nowsheen, Somaira; Yang, Xujuan

    2015-12-01

    One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic resistance. Innate cellular mechanisms have evolved to regulate replicative potential as a hedge against malignant progression. When activated in the absence of normal terminal differentiation cues, these mechanisms can result in a state of persistent cytostasis. This state, termed "senescence," can be triggered by intrinsic cellular processes such as telomere dysfunction and oncogene expression, and by exogenous factors such as DNA damaging agents or oxidative environments. Despite differences in upstream signaling, senescence often involves convergent interdependent activation of tumor suppressors p53 and p16/pRB, but can be induced, albeit with reduced sensitivity, when these suppressors are compromised. Doses of conventional genotoxic drugs required to achieve cancer cell senescence are often much lower than doses required to achieve outright cell death. Additional therapies, such as those targeting cyclin dependent kinases or components of the PI3K signaling pathway, may induce senescence specifically in cancer cells by circumventing defects in tumor suppressor pathways or exploiting cancer cells' heightened requirements for telomerase. Such treatments sufficient to induce cancer cell senescence could provide increased patient survival with fewer and less severe side effects than conventional cytotoxic regimens. This positive aspect is countered by important caveats regarding senescence reversibility, genomic instability, and paracrine effects that may increase heterogeneity and adaptive resistance of surviving cancer cells. Nevertheless, agents that effectively disrupt replicative immortality will likely be valuable components of new combinatorial approaches to cancer therapy. Copyright © 2015 The Authors

  3. Immortality in view of Maimonides and Spinoza

    Directory of Open Access Journals (Sweden)

    Morteza Shajari

    2014-12-01

    Full Text Available Desire for immortality can be seen as the essential natural impulse. Therefore, different religions and thinkers have attempted to see the issue from different viewpoints. The great Jewish philosopher. Maimonides, due to deep fixation to Judaism, has tried to express their issues to be consistent with the Bible and his own community believes. He, in his discussion of resurrection, believed to three basic steps: The Messiah, the resurrection, and the world hereafter. His standpoint of eternity is dedicated to the hereafter. And we can be immortalized only by acting and teachings in accordance with the Bible and righteousness. Like Maimonides, Spinoza – the other Jewish philosopher - considered the immortality as Ultimate bliss through which the “immutable and eternal love of God" can be achieved. In his opinion, a person reaches this stage, when the lusts and emotions can reasonably be overcome, and also, when the power and anger and contempt and disregard others will respond with love and dignity. Thus, a man can be reached its proper perfection and immortality is reached. The difference between these two philosophers is that Maimonides believes through "actual intellect" -that is Emanation of the active intellect- can be immortalized but, for Spinoza, eternity can be reached through the adequate Ideas.

  4. Dynamics of stochastic systems

    CERN Document Server

    Klyatskin, Valery I

    2005-01-01

    Fluctuating parameters appear in a variety of physical systems and phenomena. They typically come either as random forces/sources, or advecting velocities, or media (material) parameters, like refraction index, conductivity, diffusivity, etc. The well known example of Brownian particle suspended in fluid and subjected to random molecular bombardment laid the foundation for modern stochastic calculus and statistical physics. Other important examples include turbulent transport and diffusion of particle-tracers (pollutants), or continuous densities (''''oil slicks''''), wave propagation and scattering in randomly inhomogeneous media, for instance light or sound propagating in the turbulent atmosphere.Such models naturally render to statistical description, where the input parameters and solutions are expressed by random processes and fields.The fundamental problem of stochastic dynamics is to identify the essential characteristics of system (its state and evolution), and relate those to the input parameters of ...

  5. Cosmological dynamical systems

    CERN Document Server

    Leon, Genly

    2014-01-01

    In this book are studied, from the perspective of the dynamical systems, several Universe models. In chapter 1 we give a bird's eye view on cosmology and cosmological problems. Chapter 2 is devoted to a brief review on some results and useful tools from the qualitative theory of dynamical systems. They provide the theoretical basis for the qualitative study of concrete cosmological models. Chapters 1 and 2 are a review of well-known results. Chapters 3, 4, 5 and 6 are devoted to our main results. In these chapters are extended and settled in a substantially different, more strict mathematical language, several results obtained by one of us in arXiv:0812.1013 [gr-qc]; arXiv:1009.0689 [gr-qc]; arXiv:0904.1577[gr-qc]; and arXiv:0909.3571 [hep-th]. In chapter 6, we provide a different approach to the subject discussed in astro-ph/0503478. Additionally, we perform a Poincar\\'e compactification process allowing to construct a global phase space containing all the cosmological information in both finite and infinite...

  6. Data Systems Dynamic Simulator

    Science.gov (United States)

    Rouff, Christopher; Clark, Melana; Davenport, Bill; Message, Philip

    1993-01-01

    The Data System Dynamic Simulator (DSDS) is a discrete event simulation tool. It was developed for NASA for the specific purpose of evaluating candidate architectures for data systems of the Space Station era. DSDS provides three methods for meeting this requirement. First, the user has access to a library of standard pre-programmed elements. These elements represent tailorable components of NASA data systems and can be connected in any logical manner. Secondly, DSDS supports the development of additional elements. This allows the more sophisticated DSDS user the option of extending the standard element set. Thirdly, DSDS supports the use of data streams simulation. Data streams is the name given to a technique that ignores packet boundaries, but is sensitive to rate changes. Because rate changes are rare compared to packet arrivals in a typical NASA data system, data stream simulations require a fraction of the CPU run time. Additionally, the data stream technique is considerably more accurate than another commonly-used optimization technique.

  7. Duality in Dynamic Fuzzy Systems

    OpenAIRE

    Yoshida, Yuji

    1995-01-01

    This paper shows the resolvent equation, the maximum principle and the co-balayage theorem for a dynamic fuzzy system. We define a dual system for the dynamic fuzzy system, and gives a duality for Snell's optimal stopping problem by the dual system.

  8. SV40-mediated immortalization of human fibroblasts.

    Science.gov (United States)

    Ozer, H L; Banga, S S; Dasgupta, T; Houghton, J; Hubbard, K; Jha, K K; Kim, S H; Lenahan, M; Pang, Z; Pardinas, J R; Patsalis, P C

    1996-01-01

    We have identified a multistep mechanism by which the DNA virus SV40 overcomes cellular senescence. Expression of SV40 T antigen is required for both transient extension of life span and unlimited life span or immortalization. These effects are mediated through inactivation of function of growth suppressors pRB and p53 via complex formation with T antigen. However, immortalization additionally requires inactivation of a novel growth suppressor gene, which has recently been identified to be on the distal portion of the long arm of chromosome 6, designated SEN6. We propose that SEN6 is responsible for cellular senescence in fibroblasts and other cells.

  9. Otto Rank and man's urge to immortality.

    Science.gov (United States)

    Goldwert, M

    1985-04-01

    Otto Rank, one of Sigmund Freud's original followers, posited the existence of an "urge to immortality" as man's deepest drive. In his Psychology and the Soul, Rank traced the desire for immortality through four historical eras, with particular emphasis on the creativity of the hero and the artist. By the end of his life, Rank had not only repudiated orthodox psychoanalysis and developed then abandoned a psychology of the will, he had moved "beyond psychology" to a religious view of history and the nature of man.

  10. Education as Immortality: Toward the Rehabilitation of an Ideal.

    Science.gov (United States)

    Blacker, David

    1998-01-01

    Observes that immortality remains an important animating ideal for teaching and learning, despite being long neglected as theological or egoistic. Makes the case that the role of immortality in pedagogy has a long history in Western thought. Argues that individuals should recognize and address ways that longing for immortality shapes educators'…

  11. Synchronization dynamics of two different dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Albert C.J., E-mail: aluo@siue.edu [Department of Mechanical and Industrial Engineering, Southern Illinois University Edwardsville, Edwardsville, IL 62026-1805 (United States); Min Fuhong [Department of Mechanical and Industrial Engineering, Southern Illinois University Edwardsville, Edwardsville, IL 62026-1805 (United States)

    2011-06-15

    Highlights: > Synchronization dynamics of two distinct dynamical systems. > Synchronization, de-synchronization and instantaneous synchronization. > A controlled pendulum synchronizing with the Duffing oscillator. > Synchronization invariant set. > Synchronization parameter map. - Abstract: In this paper, synchronization dynamics of two different dynamical systems is investigated through the theory of discontinuous dynamical systems. The necessary and sufficient conditions for the synchronization, de-synchronization and instantaneous synchronization (penetration or grazing) are presented. Using such a synchronization theory, the synchronization of a controlled pendulum with the Duffing oscillator is systematically discussed as a sampled problem, and the corresponding analytical conditions for the synchronization are presented. The synchronization parameter study is carried out for a better understanding of synchronization characteristics of the controlled pendulum and the Duffing oscillator. Finally, the partial and full synchronizations of the controlled pendulum with periodic and chaotic motions are presented to illustrate the analytical conditions. The synchronization of the Duffing oscillator and pendulum are investigated in order to show the usefulness and efficiency of the methodology in this paper. The synchronization invariant domain is obtained. The technique presented in this paper should have a wide spectrum of applications in engineering. For example, this technique can be applied to the maneuvering target tracking, and the others.

  12. Collective dynamics of multicellular systems

    Indian Academy of Sciences (India)

    R Maithreye; C Suguna; Somdatta Sinha

    2011-11-01

    We have studied the collective behaviour of a one-dimensional ring of cells for conditions when the individual uncoupled cells show stable, bistable and oscillatory dynamics. We show that the global dynamics of this model multicellular system depends on the system size, coupling strength and the intrinsic dynamics of the cells. The intrinsic variability in dynamics of the constituent cells are suppressed to stable dynamics, or modified to intermittency under different conditions. This simple model study reveals that cell–cell communication, system size and intrinsic cellular dynamics can lead to evolution of collective dynamics in structured multicellular biological systems that is significantly different from its constituent single-cell behaviour.

  13. Dynamical Systems for Creative Technology

    NARCIS (Netherlands)

    van Amerongen, J.

    2010-01-01

    Dynamical Systems for Creative Technology gives a concise description of the physical properties of electrical, mechanical and hydraulic systems. Emphasis is placed on modelling the dynamical properties of these systems. By using a system’s approach it is shown that a limited number of mathematical

  14. Chaos for Discrete Dynamical System

    Directory of Open Access Journals (Sweden)

    Lidong Wang

    2013-01-01

    Full Text Available We prove that a dynamical system is chaotic in the sense of Martelli and Wiggins, when it is a transitive distributively chaotic in a sequence. Then, we give a sufficient condition for the dynamical system to be chaotic in the strong sense of Li-Yorke. We also prove that a dynamical system is distributively chaotic in a sequence, when it is chaotic in the strong sense of Li-Yorke.

  15. Landscape Construction in Dynamical Systems

    Science.gov (United States)

    Tang, Ying; Yuan, Ruoshi; Wang, Gaowei; Ao, Ping

    The idea of landscape has been recently applied to study various of biological problems. We demonstrate that a dynamical structure built into nonlinear dynamical systems allows us to construct such a global optimization landscape, which serves as the Lyapunov function for the ordinary differential equation. We find exact constructions on the landscape for a class of dynamical systems, including a van der Pol type oscillator, competitive Lotka-Volterra systems, and a chaotic system. The landscape constructed provides a new angle for understanding and modelling biological network dynamics.

  16. Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression.

    Science.gov (United States)

    Soo, Julia K; Mackenzie Ross, Alastair D; Kallenberg, David M; Milagre, Carla; Heung Chong, W; Chow, Jade; Hill, Lucy; Hoare, Stacey; Collinson, Rebecca S; Hossain, Mehnaz; Keith, W Nicol; Marais, Richard; Bennett, Dorothy C

    2011-06-01

    Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. Here, with new explantation methods, we investigated which classes of primary pigmented lesions are typically immortal. Nevi yielded a few proliferating cells, consistent with most nevus cells being senescent. No nevus culture (0/28) appeared immortal. Some thin and thick melanoma cultures proved immortal under these conditions, but surprisingly few (4/37). All arrested cultures displayed three senescence markers in some cells: β-galactosidase, nuclear p16, and heterochromatic foci/aggregates. However, melanoma cultures also showed features of telomeric crisis (arrest because of ultrashort telomeres). Moreover, crisis markers including anaphase bridges were frequent in uncultured vertical growth-phase (VGP) melanomas. Conversely, all immortal melanoma cultures expressed telomerase reverse transcriptase and telomerase, showing aneuploidy. The findings suggest that primary melanomas are typically precrisis, with immortalization/telomere maintenance as a late event. 2011 John Wiley & Sons A/S.

  17. Borges, immortality and the circular ruins.

    Science.gov (United States)

    Bronstein, Catalina

    2002-06-01

    The author explores ideas surrounding immortality and death focusing on the interplay between their development in two stories by Borges ('The circular ruins' and 'The immortal') and their manifestation in a patient. With the help of Borges's stories, the author addresses the desperate necessity experienced by some individuals to search for immortality. This is not just an expression of the universal wish to live forever but, at a deeper level, arises from the impossibility of bearing the mental pain of experiencing ordinary human vulnerability and loss - death being the ultimate expression of such vulnerability. It is suggested that the relentless pursuit of immortality in such individuals expresses an omnipotent phantasy of ridding the self of the emotional pain and fear that arises through being alive. It leads to a denial of the emotional significance of passage of time, of separation and sexual differences. In actuality, the individual's state of not feeling approximates to a complete loss of human identity and emotional death, with no place for any meaningful others. The individual him/herself becomes a 'mere image', living in a delusional world peopled by him/herself and his/ her projections, and ending up trapped inside the circular ruins he/she has generated. The horror experienced at the stark awareness of the individual's emotional death and the wish to re-establish contact with the good internal objects that have been attacked sets in motion the long process of searching for the recovery of a sense of temporality (that would still include the wish for immortality) and, with it, a sense of identity.

  18. Structural dynamics in rotating systems

    Science.gov (United States)

    Kiraly, Louis J.

    1993-01-01

    Major issues and recent advances in the structural dynamics of rotating systems are summarized. The objectives and benefits of such systems are briefly discussed. Directions for future research are suggested.

  19. Chaotic Dynamics in Hybrid Systems

    NARCIS (Netherlands)

    P.J. Collins (Pieter)

    2008-01-01

    htmlabstractIn this paper we give an overview of some aspects of chaotic dynamics in hybrid systems, which comprise different types of behaviour. Hybrid systems may exhibit discontinuous dependence on initial conditions leading to new dynamical phenomena. We indicate how methods from topological

  20. Chaotic dynamics in hybrid systems

    NARCIS (Netherlands)

    P.J. Collins (Pieter)

    2008-01-01

    htmlabstractIn this paper we give an overview of some aspects of chaotic dynamics in hybrid systems, which comprise different types of behaviour. Hybrid systems may exhibit discontinuous dependence on initial conditions leading to new dynamical phenomena. We indicate how methods from topological

  1. A new hyperchaotic dynamical system

    Institute of Scientific and Technical Information of China (English)

    Liu Chong-Xin

    2007-01-01

    In this paper a new hyperchaotic system is reported. Some basic dynamical properties, such as continuous specare studied. Dynamical behaviours of the new hyperchaotic system are proved by not only numerical simulation and brief theoretical analysis but also an electronic circuit experiment.

  2. A block in lineage differentiation of immortal human mammary stem / progenitor cells by ectopically-expressed oncogenes

    Directory of Open Access Journals (Sweden)

    Xiangshan Zhao

    2011-01-01

    Full Text Available Introduction: Emerging evidence suggests a direct role of cancer stem cells (CSCs in the development of breast cancer. In vitro cellular models that recapitulate properties of CSCs are therefore highly desirable. We have previously shown that normal human mammary epithelial cells (hMECs immortalized with human telomerase reverse transcriptase (hTERT possess properties of mammary stem / progenitor cells. Materials and Methods: In the present study, we used this cell system to test the idea that other known hMEC-immortalizing oncogenes (RhoA, HPVE6, HPVE7, p53 mutant, and treatment with g-radiation, share with hTERT, the ability to maintain mammary stem / progenitor cells. Results: The results presented here demonstrate that similar to hMECs immortalized with hTERT, all hMEC cell lines immortalized using various oncogenic strategies express stem / progenitor cell markers. Furthermore, analyses using 2D and 3D culture assays demonstrate that all the immortal cell lines retain their ability to self-renew and to differentiate along the luminal lineage. Remarkably, the stem / progenitor cell lines generated using various oncogenic strategies exhibit a block in differentiation along the myoepithelial lineage, a trait that is retained on hTERT-immortalized stem / progenitors. The inability to differentiate along the myoepithelial lineage could be induced by ectopic mutant p53 expression in hTERT-immortalized hMEC. Conclusions: Our studies demonstrate that stem / progenitor cell characteristics of hMECs are maintained upon immortalization by using various cancer-relevant oncogenic strategies. Oncogene-immortalized hMECs show a block in their ability to differentiate along the myoepithelial lineage. Abrogation of the myoepithelial differentiation potential by a number of distinct oncogenic insults suggests a potential explanation for the predominance of luminal and rarity of myoepithelial breast cancers.

  3. Recurrence for random dynamical systems

    CERN Document Server

    Marie, Philippe

    2009-01-01

    This paper is a first step in the study of the recurrence behavior in random dynamical systems and randomly perturbed dynamical systems. In particular we define a concept of quenched and annealed return times for systems generated by the composition of random maps. We moreover prove that for super-polynomially mixing systems, the random recurrence rate is equal to the local dimension of the stationary measure.

  4. ROLLING MILL SYSTEM DYNAMIC DESIGN

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It is studied how the aluminum foil chatter mark is produced and controlledThe stableness of hydraulic AGC system,fluid vibration of capsule system,and electromechanical coupling of AC/AC VVVF system and dec oupling are also studiedIt is shown that rolling mill design should go to syst em dynamic design from traditional designThe framed drawing of system dynamic design program is presented

  5. On Causality in Dynamical Systems

    CERN Document Server

    Harnack, Daniel

    2016-01-01

    Identification of causal links is fundamental for the analysis of complex systems. In dynamical systems, however, nonlinear interactions may hamper separability of subsystems which poses a challenge for attempts to determine the directions and strengths of their mutual influences. We found that asymmetric causal influences between parts of a dynamical system lead to characteristic distortions in the mappings between the attractor manifolds reconstructed from respective local observables. These distortions can be measured in a model-free, data-driven manner. This approach extends basic intuitions about cause-effect relations to deterministic dynamical systems and suggests a mathematically well defined explanation of results obtained from previous methods based on state space reconstruction.

  6. Ergodic theory and dynamical systems

    CERN Document Server

    Coudène, Yves

    2016-01-01

    This textbook is a self-contained and easy-to-read introduction to ergodic theory and the theory of dynamical systems, with a particular emphasis on chaotic dynamics. This book contains a broad selection of topics and explores the fundamental ideas of the subject. Starting with basic notions such as ergodicity, mixing, and isomorphisms of dynamical systems, the book then focuses on several chaotic transformations with hyperbolic dynamics, before moving on to topics such as entropy, information theory, ergodic decomposition and measurable partitions. Detailed explanations are accompanied by numerous examples, including interval maps, Bernoulli shifts, toral endomorphisms, geodesic flow on negatively curved manifolds, Morse-Smale systems, rational maps on the Riemann sphere and strange attractors. Ergodic Theory and Dynamical Systems will appeal to graduate students as well as researchers looking for an introduction to the subject. While gentle on the beginning student, the book also contains a number of commen...

  7. Dynamical systems in classical mechanics

    CERN Document Server

    Kozlov, V V

    1995-01-01

    This book shows that the phenomenon of integrability is related not only to Hamiltonian systems, but also to a wider variety of systems having invariant measures that often arise in nonholonomic mechanics. Each paper presents unique ideas and original approaches to various mathematical problems related to integrability, stability, and chaos in classical dynamics. Topics include… the inverse Lyapunov theorem on stability of equilibria geometrical aspects of Hamiltonian mechanics from a hydrodynamic perspective current unsolved problems in the dynamical systems approach to classical mechanics

  8. Kuramoto dynamics in Hamiltonian systems.

    Science.gov (United States)

    Witthaut, Dirk; Timme, Marc

    2014-09-01

    The Kuramoto model constitutes a paradigmatic model for the dissipative collective dynamics of coupled oscillators, characterizing in particular the emergence of synchrony (phase locking). Here we present a classical Hamiltonian (and thus conservative) system with 2N state variables that in its action-angle representation exactly yields Kuramoto dynamics on N-dimensional invariant manifolds. We show that locking of the phase of one oscillator on a Kuramoto manifold to the average phase emerges where the transverse Hamiltonian action dynamics of that specific oscillator becomes unstable. Moreover, the inverse participation ratio of the Hamiltonian dynamics perturbed off the manifold indicates the global synchronization transition point for finite N more precisely than the standard Kuramoto order parameter. The uncovered Kuramoto dynamics in Hamiltonian systems thus distinctly links dissipative to conservative dynamics.

  9. Reasoning about Dynamic Normative Systems

    NARCIS (Netherlands)

    Knobbout, Max; Dastani, Mehdi; Meyer, John-Jules Charles

    2014-01-01

    The use of normative systems is widely accepted as an effective approach to control and regulate the behaviour of agents in multiagent systems. When norms are added to a normative system, the behaviour of such a system changes. As of yet, there is no clear formal methodology to model the dynamics of

  10. Construction and identification of immortalized rat astrocyte cell line expressing enkephalin

    Institute of Scientific and Technical Information of China (English)

    XU Ying; TIAN Yu-ke; TIAN Xue-bi; AN Ke; YANG Hui

    2007-01-01

    Objective: To provide a sound cell source for further ex-vivo gene therapy for chronic pain, we attempt to develop an immortalized rat astrocyte cell line that expresses enkephalin regulated by doxycycline.Methods: Retrovirus infection method was employed to develop an immortalized rat astrocyte cell line that could express enkephalin regulated by doxycycline. The hPPE gene expression level of immoralized astroyte cells (IAC)/hPPE was detected by RT-PCR, indirect immunofiuorescence staining and radioimmunoassay.Results: IAC carrying Tet-on system transfected with preproenkephalin gene could secrete enkephalin that was regulated by doxycycline in a dose-dependent manner and hPPE gene activation could be repeated in on-off-on cycles through administration or removal of doxycycline.Conclusion: An immortalized rat astrocyte cell line that secrete enkephalin under the control of doxycycline is established successfully, which provides a research basis for transgenic cell transplantation for analgesia.

  11. Dynamic Systems and Software

    DEFF Research Database (Denmark)

    Thomsen, Per Grove

    1996-01-01

    A one-dimensional model with axial discretization of engine components has been formulated using tha balance equations for mass energy and momentum and the ideal gas equation of state. ODE's that govern the dynamic behaviour of the regenerator matrix temperatures are included in the model. Known ...

  12. Dynamic Systems and Software

    DEFF Research Database (Denmark)

    Thomsen, Per Grove

    1996-01-01

    A one-dimensional model with axial discretization of engine components has been formulated using tha balance equations for mass energy and momentum and the ideal gas equation of state. ODE's that govern the dynamic behaviour of the regenerator matrix temperatures are included in the model. Known...

  13. Permutation Complexity in Dynamical Systems

    CERN Document Server

    Amigo, Jose

    2010-01-01

    The study of permutation complexity can be envisioned as a new kind of symbolic dynamics whose basic blocks are ordinal patterns, that is, permutations defined by the order relations among points in the orbits of dynamical systems. Since its inception in 2002 the concept of permutation entropy has sparked a new branch of research in particular regarding the time series analysis of dynamical systems that capitalizes on the order structure of the state space. Indeed, on one hand ordinal patterns and periodic points are closely related, yet ordinal patterns are amenable to numerical methods, while periodicity is not. Another interesting feature is that since it can be shown that random (unconstrained) dynamics has no forbidden patterns with probability one, their existence can be used as a fingerprint to identify any deterministic origin of orbit generation. This book is primarily addressed to researchers working in the field of nonlinear dynamics and complex systems, yet will also be suitable for graduate stude...

  14. Achieving immortality in the C. elegans germline.

    Science.gov (United States)

    Smelick, Chris; Ahmed, Shawn

    2005-01-01

    Germline immortality is a topic that has intrigued theoretical biologists interested in aging for over a century. The germ cell lineage can be passed from one generation to the next, indefinitely. In contrast, somatic cells are typically only needed for a single generation and are then discarded. Germ cells may, therefore, harbor rejuvenation mechanisms that enable them to proliferate for eons. Such processes are thought to be either absent from or down-regulated in somatic cells, although cell non-autonomous forms of rejuvenation are formally possible. A thorough description of mechanisms that foster eternal youth in germ cells is lacking. The mysteries of germline immortality are being addressed in the nematode Caenorhabditis elegans by studying mutants that reproduce normally for several generations but eventually become sterile. The mortal germline mutants probably become sterile as a consequence of accumulating various forms of heritable cellular damage. Such mutants are abundant, indicating that several different biochemical pathways are required to rejuvenate the germline. Thus, forward genetics should help to define mechanisms that enable the germline to achieve immortality.

  15. Immortality versus resurrection in the Christian tradition.

    Science.gov (United States)

    Murphy, Nancey

    2011-10-01

    For those in contemporary society who believe in an afterlife, there are a number of views available. The most common may be based on belief in an immortal soul. However, the early Christian account was, instead, bodily resurrection. As Christianity moved throughout the Mediterranean world, apologists and theologians adapted their teaching on human nature and the afterlife to Greek and Roman philosophies. By the time of Augustine (d. 430), the doctrines of body-soul dualism and immortality of the soul were firmly entrenched in Christian teaching. The incorporation of the concept of an immortal soul into Christian accounts of life after death produced a hybrid account. The body dies, the soul (at least of those who were to be saved) travels to heaven. At the end of history, there would be a general resurrection, and the souls would be reunited with their bodies, although the bodies would be in a transformed, indestructible state. This hybrid account of life after death went largely uncontested until the twentieth century. In this essay, I describe this history and argue for a return to the early Christian view of humans as a unity, not a duality, and for belief in resurrection of the body as the appropriate expectation for eternal life. This would not only be truer to Christian sources, but, valuable, I believe, in focusing Christian attention on the need to care for the environment. © 2011 New York Academy of Sciences.

  16. Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality

    Science.gov (United States)

    Solinas-Toldo, Sabina; Dürst, Matthias; Lichter, Peter

    1997-01-01

    High risk human papillomaviruses (HPVs) known to be closely associated with cervical cancer, such as HPV16 and HPV18, have the potential to immortalize human epithelial cells in culture. Four lines of HPV-transfected keratinocytes were analyzed by comparative genomic hybridization at different time points after transfection. A number of chromosomal imbalances was found to be highly characteristic for the cultures progressing toward immortality. Whereas several of these were new and previously not found as recurrent aberrations in cervical tumors, some were identical to chromosomal changes observed during cervical carcinogenesis. The data put new emphasis on the studied cell system as a relevant model for HPV-induced pathogenesis. PMID:9108068

  17. Approximate reduction of dynamical systems

    CERN Document Server

    Tabuada, Paulo; Julius, Agung; Pappas, George J

    2007-01-01

    The reduction of dynamical systems has a rich history, with many important applications related to stability, control and verification. Reduction of nonlinear systems is typically performed in an exact manner - as is the case with mechanical systems with symmetry--which, unfortunately, limits the type of systems to which it can be applied. The goal of this paper is to consider a more general form of reduction, termed approximate reduction, in order to extend the class of systems that can be reduced. Using notions related to incremental stability, we give conditions on when a dynamical system can be projected to a lower dimensional space while providing hard bounds on the induced errors, i.e., when it is behaviorally similar to a dynamical system on a lower dimensional space. These concepts are illustrated on a series of examples.

  18. Lectures on chaotic dynamical systems

    CERN Document Server

    Afraimovich, Valentin

    2002-01-01

    This book is devoted to chaotic nonlinear dynamics. It presents a consistent, up-to-date introduction to the field of strange attractors, hyperbolic repellers, and nonlocal bifurcations. The authors keep the highest possible level of "physical" intuition while staying mathematically rigorous. In addition, they explain a variety of important nonstandard algorithms and problems involving the computation of chaotic dynamics. The book will help readers who are not familiar with nonlinear dynamics to understand and appreciate sophisticated modern dynamical systems and chaos. Intended for courses in either mathematics, physics, or engineering, prerequisites are calculus, differential equations, and functional analysis.

  19. Dynamic Ocean Track System Plus -

    Data.gov (United States)

    Department of Transportation — Dynamic Ocean Track System Plus (DOTS Plus) is a planning tool implemented at the ZOA, ZAN, and ZNY ARTCCs. It is utilized by Traffic Management Unit (TMU) personnel...

  20. Dynamical systems in population biology

    CERN Document Server

    Zhao, Xiao-Qiang

    2017-01-01

    This research monograph provides an introduction to the theory of nonautonomous semiflows with applications to population dynamics. It develops dynamical system approaches to various evolutionary equations such as difference, ordinary, functional, and partial differential equations, and pays more attention to periodic and almost periodic phenomena. The presentation includes persistence theory, monotone dynamics, periodic and almost periodic semiflows, basic reproduction ratios, traveling waves, and global analysis of prototypical population models in ecology and epidemiology. Research mathematicians working with nonlinear dynamics, particularly those interested in applications to biology, will find this book useful. It may also be used as a textbook or as supplementary reading for a graduate special topics course on the theory and applications of dynamical systems. Dr. Xiao-Qiang Zhao is a University Research Professor at Memorial University of Newfoundland, Canada. His main research interests involve applied...

  1. Aging and immortality in a cell proliferation model.

    Science.gov (United States)

    Antal, T; Blagoev, K B; Trugman, S A; Redner, S

    2007-10-07

    We investigate a model of cell division in which the length of telomeres within a cell regulates its proliferative potential. At each division, telomeres undergo a systematic length decrease as well as a superimposed fluctuation due to exchange of telomere DNA between the two daughter cells. A cell becomes senescent when one or more of its telomeres become shorter than a critical length. We map this telomere dynamics onto a biased branching-diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. Using first-passage ideas, we find a phase transition between finite lifetime and immortality (infinite proliferation) of the cell population as a function of the influence of telomere shortening, fluctuations, and cell division.

  2. DNA asymmetry in stem cells - immortal or mortal?

    Science.gov (United States)

    Yadlapalli, Swathi; Yamashita, Yukiko M

    2013-09-15

    The immortal strand hypothesis proposes that stem cells retain a template copy of genomic DNA (i.e. an 'immortal strand') to avoid replication-induced mutations. An alternative hypothesis suggests that certain cells segregate sister chromatids non-randomly to transmit distinct epigenetic information. However, this area of research has been highly controversial, with conflicting data even from the same cell types. Moreover, historically, the same term of 'non-random sister chromatid segregation' or 'biased sister chromatid segregation' has been used to indicate distinct biological processes, generating a confusion in the biological significance and potential mechanism of each phenomenon. Here, we discuss the models of non-random sister chromatid segregation, and we explore the strengths and limitations of the various techniques and experimental model systems used to study this question. We also describe our recent study on Drosophila male germline stem cells, where sister chromatids of X and Y chromosomes are segregated non-randomly during cell division. We aim to integrate the existing evidence to speculate on the underlying mechanisms and biological relevance of this long-standing observation on non-random sister chromatid segregation.

  3. Nonlinear dynamics in biological systems

    CERN Document Server

    Carballido-Landeira, Jorge

    2016-01-01

    This book presents recent research results relating to applications of nonlinear dynamics, focusing specifically on four topics of wide interest: heart dynamics, DNA/RNA, cell mobility, and proteins. The book derives from the First BCAM Workshop on Nonlinear Dynamics in Biological Systems, held in June 2014 at the Basque Center of Applied Mathematics (BCAM). At this international meeting, researchers from different but complementary backgrounds, including molecular dynamics, physical chemistry, bio-informatics and biophysics, presented their most recent results and discussed the future direction of their studies using theoretical, mathematical modeling and experimental approaches. Such was the level of interest stimulated that the decision was taken to produce this publication, with the organizers of the event acting as editors. All of the contributing authors are researchers working on diverse biological problems that can be approached using nonlinear dynamics. The book will appeal especially to applied math...

  4. Self-Supervised Dynamical Systems

    Science.gov (United States)

    Zak, Michail

    2003-01-01

    Some progress has been made in a continuing effort to develop mathematical models of the behaviors of multi-agent systems known in biology, economics, and sociology (e.g., systems ranging from single or a few biomolecules to many interacting higher organisms). Living systems can be characterized by nonlinear evolution of probability distributions over different possible choices of the next steps in their motions. One of the main challenges in mathematical modeling of living systems is to distinguish between random walks of purely physical origin (for instance, Brownian motions) and those of biological origin. Following a line of reasoning from prior research, it has been assumed, in the present development, that a biological random walk can be represented by a nonlinear mathematical model that represents coupled mental and motor dynamics incorporating the psychological concept of reflection or self-image. The nonlinear dynamics impart the lifelike ability to behave in ways and to exhibit patterns that depart from thermodynamic equilibrium. Reflection or self-image has traditionally been recognized as a basic element of intelligence. The nonlinear mathematical models of the present development are denoted self-supervised dynamical systems. They include (1) equations of classical dynamics, including random components caused by uncertainties in initial conditions and by Langevin forces, coupled with (2) the corresponding Liouville or Fokker-Planck equations that describe the evolutions of probability densities that represent the uncertainties. The coupling is effected by fictitious information-based forces, denoted supervising forces, composed of probability densities and functionals thereof. The equations of classical mechanics represent motor dynamics that is, dynamics in the traditional sense, signifying Newton s equations of motion. The evolution of the probability densities represents mental dynamics or self-image. Then the interaction between the physical and

  5. Nonnegative and Compartmental Dynamical Systems

    CERN Document Server

    Haddad, Wassim M; Hui, Qing

    2010-01-01

    This comprehensive book provides the first unified framework for stability and dissipativity analysis and control design for nonnegative and compartmental dynamical systems, which play a key role in a wide range of fields, including engineering, thermal sciences, biology, ecology, economics, genetics, chemistry, medicine, and sociology. Using the highest standards of exposition and rigor, the authors explain these systems and advance the state of the art in their analysis and active control design. Nonnegative and Compartmental Dynamical Systems presents the most complete treatment available o

  6. Dynamical system approach to phyllotaxis

    DEFF Research Database (Denmark)

    D'ovidio, Francesco; Mosekilde, Erik

    2000-01-01

    and not a dynamical system, mainly because new active elements are added at each step, and thus the dimension of the "natural" phase space is not conserved. Here a construction is presented by which a well defined dynamical system can be obtained, and a bifurcation analysis can be carried out. Stable and unstable...... of the Jacobian, and thus the eigenvalues, is given. It is likely that problems of the above type often arise in biology, and especially in morphogenesis, where growing systems are modeled....

  7. Dynamically reconfigurable photovoltaic system

    Energy Technology Data Exchange (ETDEWEB)

    Okandan, Murat; Nielson, Gregory N.

    2016-12-27

    A PV system composed of sub-arrays, each having a group of PV cells that are electrically connected to each other. A power management circuit for each sub-array has a communications interface and serves to connect or disconnect the sub-array to a programmable power grid. The power grid has bus rows and bus columns. A bus management circuit is positioned at a respective junction of a bus column and a bus row and is programmable through its communication interface to connect or disconnect a power path in the grid. As a result, selected sub-arrays are connected by selected power paths to be in parallel so as to produce a low system voltage, and, alternately in series so as to produce a high system voltage that is greater than the low voltage by at least a factor of ten.

  8. Experimental Modeling of Dynamic Systems

    DEFF Research Database (Denmark)

    Knudsen, Morten Haack

    2006-01-01

    An engineering course, Simulation and Experimental Modeling, has been developed that is based on a method for direct estimation of physical parameters in dynamic systems. Compared with classical system identification, the method appears to be easier to understand, apply, and combine with physical...

  9. Dynamic probabilistic systems

    CERN Document Server

    Howard, Ronald A

    2007-01-01

    This book is an integrated work published in two volumes. The first volume treats the basic Markov process and its variants; the second, semi-Markov and decision processes. Its intent is to equip readers to formulate, analyze, and evaluate simple and advanced Markov models of systems, ranging from genetics and space engineering to marketing. More than a collection of techniques, it constitutes a guide to the consistent application of the fundamental principles of probability and linear system theory.Author Ronald A. Howard, Professor of Management Science and Engineering at Stanford University

  10. Amoebal endosymbiont Parachlamydia acanthamoebae Bn9 can grow in immortal human epithelial HEp-2 cells at low temperature; an in vitro model system to study chlamydial evolution.

    Directory of Open Access Journals (Sweden)

    Chikayo Yamane

    Full Text Available Ancient chlamydiae diverged into pathogenic and environmental chlamydiae 0.7-1.4 billion years ago. However, how pathogenic chlamydiae adapted to mammalian cells that provide a stable niche at approximately 37 °C, remains unknown, although environmental chlamydiae have evolved as endosymbionts of lower eukaryotes in harsh niches of relatively low temperatures. Hence, we assessed whether an environmental chlamydia, Parachlamydia Bn9, could grow in human HEp-2 cells at a low culture temperature of 30 °C. The assessment of inclusion formation by quantitative RT-PCR revealed that the numbers of bacterial inclusion bodies and the transcription level of 16SrRNA significantly increased after culture at 30 °C compared to at 37 °C. Confocal microscopy showed that the bacteria were located close to HEp-2 nuclei and were actively replicative. Transmission electron microscopy also revealed replicating bacteria consisting of reticular bodies, but with a few elementary bodies. Cytochalasin D and rifampicin inhibited inclusion formation. Lactacystin slightly inhibited bacterial inclusion formation. KEGG analysis using a draft genome sequence of the bacteria revealed that it possesses metabolic pathways almost identical to those of pathogenic chlamydia. Interestingly, comparative genomic analysis with pathogenic chlamydia revealed that the Parachlamydia similarly possess the genes encoding Type III secretion system, but lacking genes encoding inclusion membrane proteins (IncA to G required for inclusion maturation. Taken together, we conclude that ancient chlamydiae had the potential to grow in human cells, but overcoming the thermal gap was a critical event for chlamydial adaptation to human cells.

  11. Amoebal Endosymbiont Parachlamydia acanthamoebae Bn9 Can Grow in Immortal Human Epithelial HEp-2 Cells at Low Temperature; An In Vitro Model System to Study Chlamydial Evolution

    Science.gov (United States)

    Nakamura, Shinji; Matsuo, Junji; Ishida, Kasumi; Yamazaki, Sumire; Oguri, Satoshi; Shouji, Natsumi; Hayashi, Yasuhiro; Yoshida, Mitsutaka; Yimin; Yamaguchi, Hiroyuki

    2015-01-01

    Ancient chlamydiae diverged into pathogenic and environmental chlamydiae 0.7–1.4 billion years ago. However, how pathogenic chlamydiae adapted to mammalian cells that provide a stable niche at approximately 37°C, remains unknown, although environmental chlamydiae have evolved as endosymbionts of lower eukaryotes in harsh niches of relatively low temperatures. Hence, we assessed whether an environmental chlamydia, Parachlamydia Bn9, could grow in human HEp-2 cells at a low culture temperature of 30°C. The assessment of inclusion formation by quantitative RT-PCR revealed that the numbers of bacterial inclusion bodies and the transcription level of 16SrRNA significantly increased after culture at 30°C compared to at 37°C. Confocal microscopy showed that the bacteria were located close to HEp-2 nuclei and were actively replicative. Transmission electron microscopy also revealed replicating bacteria consisting of reticular bodies, but with a few elementary bodies. Cytochalasin D and rifampicin inhibited inclusion formation. Lactacystin slightly inhibited bacterial inclusion formation. KEGG analysis using a draft genome sequence of the bacteria revealed that it possesses metabolic pathways almost identical to those of pathogenic chlamydia. Interestingly, comparative genomic analysis with pathogenic chlamydia revealed that the Parachlamydia similarly possess the genes encoding Type III secretion system, but lacking genes encoding inclusion membrane proteins (IncA to G) required for inclusion maturation. Taken together, we conclude that ancient chlamydiae had the potential to grow in human cells, but overcoming the thermal gap was a critical event for chlamydial adaptation to human cells. PMID:25643359

  12. Parametric Resonance in Dynamical Systems

    CERN Document Server

    Nijmeijer, Henk

    2012-01-01

    Parametric Resonance in Dynamical Systems discusses the phenomenon of parametric resonance and its occurrence in mechanical systems,vehicles, motorcycles, aircraft and marine craft, and micro-electro-mechanical systems. The contributors provide an introduction to the root causes of this phenomenon and its mathematical equivalent, the Mathieu-Hill equation. Also included is a discussion of how parametric resonance occurs on ships and offshore systems and its frequency in mechanical and electrical systems. This book also: Presents the theory and principles behind parametric resonance Provides a unique collection of the different fields where parametric resonance appears including ships and offshore structures, automotive vehicles and mechanical systems Discusses ways to combat, cope with and prevent parametric resonance including passive design measures and active control methods Parametric Resonance in Dynamical Systems is ideal for researchers and mechanical engineers working in application fields such as MEM...

  13. Managing Complex Dynamical Systems

    Science.gov (United States)

    Cox, John C.; Webster, Robert L.; Curry, Jeanie A.; Hammond, Kevin L.

    2011-01-01

    Management commonly engages in a variety of research designed to provide insight into the motivation and relationships of individuals, departments, organizations, etc. This paper demonstrates how the application of concepts associated with the analysis of complex systems applied to such data sets can yield enhanced insights for managerial action.

  14. Multibody systems and robot dynamics

    OpenAIRE

    Schiehlen, Werner

    1990-01-01

    The method of multibody system has been developed during the last two decades with application to various engineering topics, including robotics and walking machines. On the other hand, special algorithms for robot dynamics are available featuring the high computational efficiency required for control purposes. This paper shows the close relation between both approaches. Essential criteria for the effeciency of dynamics software are the numbers of coordinates used, which should be minimal. Fo...

  15. Circadian-independent cell mitosis in immortalized fibroblasts.

    Science.gov (United States)

    Yeom, Mijung; Pendergast, Julie S; Ohmiya, Yoshihiro; Yamazaki, Shin

    2010-05-25

    Two prominent timekeeping systems, the cell cycle, which controls cell division, and the circadian system, which controls 24-h rhythms of physiology and behavior, are found in nearly all living organisms. A distinct feature of circadian rhythms is that they are temperature-compensated such that the period of the rhythm remains constant (approximately 24 h) at different ambient temperatures. Even though the speed of cell division, or growth rate, is highly temperature-dependent, the cell-mitosis rhythm is temperature-compensated. Twenty-four-hour fluctuations in cell division have also been observed in numerous species, suggesting that the circadian system is regulating the timing of cell division. We tested whether the cell-cycle rhythm was coupled to the circadian system in immortalized rat-1 fibroblasts by monitoring cell-cycle gene promoter-driven luciferase activity. We found that there was no consistent phase relationship between the circadian and cell cycles, and that the cell-cycle rhythm was not temperature-compensated in rat-1 fibroblasts. These data suggest that the circadian system does not regulate the cell-mitosis rhythm in rat-1 fibroblasts. These findings are inconsistent with numerous studies that suggest that cell mitosis is regulated by the circadian system in mammalian tissues in vivo. To account for this discrepancy, we propose two possibilities: (i) There is no direct coupling between the circadian rhythm and cell cycle but the timing of cell mitosis is synchronized with the rhythmic host environment, or (ii) coupling between the circadian rhythm and cell cycle exists in normal cells but it is disconnected in immortalized cells.

  16. ON COMPLEX DYNAMIC CONTROL SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    CHENG Daizhan

    2003-01-01

    This paper presents some recent works on the control of dynamic systems, which have certain complex properties caused by singularity of the nonlinear structures, structure-varyings, or evolution process etc. First, we consider the structure singularity of nonlinear control systems. It was revealed that the focus of researches on nonlinear control theory is shifting from regular systems to singular systems. The singularity of nonlinear systems causes certain complexity. Secondly, the switched systems are considered. For such systems the complexity is caused by the structure varying. We show that the switched systems have significant characteristics of complex systems. Finally, we investigate the evolution systems. The evolution structure makes complexity, and itself is a proper model for complex systems.

  17. Precise conditional immortalization of mouse cells using tetracycline-regulated SV40 large T-antigen.

    Science.gov (United States)

    Anastassiadis, Konstantinos; Rostovskaya, Maria; Lubitz, Sandra; Weidlich, Stefanie; Stewart, A Francis

    2010-04-01

    Cellular immortalization provides a way for expansion and subsequent molecular characterization of rare cell types. Ideally, immortalization can be achieved by the reversible expression of immortalizing proteins. Here, we describe the use of conditional immortalization based on a modified tetracycline-regulated system for the expression of SV40 large T-antigen in embryonic stem (ES) cells and mice. The modified system relies on a codon improved reverse tetracycline transactivator (irtTA) fused to the ligand-binding domain (LBD) of the androgen receptor (irtTA-ABD) or of a mutated glucocorticoid receptor (irtTA-GBD*). Induction of T-antigen is conferred only after addition of two ligands, one to activate the LBD (mibolerone for irtTA-ABD or dexamethasone for irtTA-GBD*) and one to activate the tetracycline transactivator (doxycycline). In ES cells, changes in gene expression upon large T induction were limited and reversible upon deinduction. Similarly, expression of T-antigen was very tightly regulated in mice. We have isolated and expanded bone marrow mesenchymal stem cells that could be genetically manipulated and maintained their differentiation properties after several passages of expansion under conditions that induce the expression of large T-antigen. 2010 Wiley-Liss, Inc.

  18. Dynamical Systems Some Computational Problems

    CERN Document Server

    Guckenheimer, J; Guckenheimer, John; Worfolk, Patrick

    1993-01-01

    We present several topics involving the computation of dynamical systems. The emphasis is on work in progress and the presentation is informal -- there are many technical details which are not fully discussed. The topics are chosen to demonstrate the various interactions between numerical computation and mathematical theory in the area of dynamical systems. We present an algorithm for the computation of stable manifolds of equilibrium points, describe the computation of Hopf bifurcations for equilibria in parametrized families of vector fields, survey the results of studies of codimension two global bifurcations, discuss a numerical analysis of the Hodgkin and Huxley equations, and describe some of the effects of symmetry on local bifurcation.

  19. Senescence and immortality in hepatocellular carcinoma.

    Science.gov (United States)

    Ozturk, Mehmet; Arslan-Ergul, Ayca; Bagislar, Sevgi; Senturk, Serif; Yuzugullu, Haluk

    2009-12-01

    Cellular senescence is a process leading to terminal growth arrest with characteristic morphological features. This process is mediated by telomere-dependent, oncogene-induced and ROS-induced pathways, but persistent DNA damage is the most common cause. Senescence arrest is mediated by p16(INK4a)- and p21(Cip1)-dependent pathways both leading to retinoblastoma protein (pRb) activation. p53 plays a relay role between DNA damage sensing and p21(Cip1) activation. pRb arrests the cell cycle by recruiting proliferation genes to facultative heterochromatin for permanent silencing. Replicative senescence that occurs in hepatocytes in culture and in liver cirrhosis is associated with lack of telomerase activity and results in telomere shortening. Hepatocellular carcinoma (HCC) cells display inactivating mutations of p53 and epigenetic silencing of p16(INK4a). Moreover, they re-express telomerase reverse transcriptase required for telomere maintenance. Thus, senescence bypass and cellular immortality is likely to contribute significantly to HCC development. Oncogene-induced senescence in premalignant lesions and reversible immortality of cancer cells including HCC offer new potentials for tumor prevention and treatment.

  20. Novel isolation and biochemical characterization of immortalized fibroblasts for tissue engineering vocal fold lamina propria.

    Science.gov (United States)

    Chen, Xia; Thibeault, Susan L

    2009-06-01

    Tissue regeneration of the vocal fold lamina propria extracellular matrix (ECM) will be facilitated by the use of suitable vocal fold fibroblast (VFF) cell lines in appropriate model systems. Primary human VFFs (hVFFs) were steadily transduced by a retroviral vector containing human telomerase reverse transcriptase (hTERT) gene; immortalized cells grew and divided vigorously for more than 120 days. Biochemical characterization of the six transduced lines included, at different time points, expression of hTERT, telomerase activity, telomere lengths, and transcript levels of ECM constituents. Telomere lengths of the transfected lines were elongated and stable. Gene expression levels of collagen Ialpha1, collagen Ialpha2, collagen VIalpha3, elastin, and fibronectin were measured between the transduced cell clones and the primary hVFFs to verify transcription. Absence of inter- and intraspecies contamination was confirmed with DNA fingerprinting and karyotype analysis. Cell morphology, growth, and transcription expression were examined on 2D scaffolds-collagen, fibronectin, and hyaluronic acid. Immortalized hVFFs demonstrated normal attachment and spread on 2D scaffolds. Collagen Ialpha1, collagen Ialpha2, collagen VIalpha3, elastin, and fibronectin transcript expression was measured from immortalized hVFFs, for all surfaces. This is the first report of immortalization and biochemical characterization of hVFFs, providing a novel and invaluable tool for tissue regeneration applications in the larynx.

  1. Dynamical stability of Hamiltonian systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Dynamical stability has become the center of study on Hamiltonian system. In this article we intro-duce the recent development in some areas closely related to this topic, such as the KAM theory, Mather theory, Arnolddiffusion and non-singular collision of n-body problem.

  2. Advanced dynamics of mechanical systems

    CERN Document Server

    Cheli, Federico

    2015-01-01

    This book introduces a general approach for schematization of mechanical systems with rigid and deformable bodies. It proposes a systems approach to reproduce the interaction of the mechanical system with different force fields such as those due to the action of fluids or contact forces between bodies, i.e., with forces dependent on the system states, introducing the concepts of the stability of motion. In the first part of the text mechanical systems with one or more degrees of freedom with large motion and subsequently perturbed in the neighborhood of the steady state position are analyzed. Both discrete and continuous systems (modal approach, finite elements) are analyzed. The second part is devoted to the study of mechanical systems subject to force fields, the rotor dynamics, techniques of experimental identification of the parameters, and random excitations. The book will be especially valuable for students of engineering courses in Mechanical Systems, Aerospace, Automation, and Energy but will also b...

  3. Controlling dynamics in diatomic systems

    Indian Academy of Sciences (India)

    Praveen Kumar; Harjinder Singh

    2007-09-01

    Controlling molecular energetics using laser pulses is exemplified for nuclear motion in two different diatomic systems. The problem of finding the optimized field for maximizing a desired quantum dynamical target is formulated using an iterative method. The method is applied for two diatomic systems, HF and OH. The power spectra of the fields and evolution of populations of different vibrational states during transitions are obtained.

  4. Algebraic Structure of Dynamical Systems

    Science.gov (United States)

    2017-05-22

    Scholar project report; no. 461 (2017) ALGEBRAIC STRUCTURE OF DYNAMICAL SYSTEMS by MIDN 1/C James P. Talisse United States Naval Academy Annapolis, MD...based on the structure of algebraic objects associated with it. In this project we study two algebraic objects, centralizers and topological full groups...group completely defines the system up to time reversal. We apply numerical estimates to draw conclusions about the algebraic properties of this group

  5. Adaptive, dynamic, and resilient systems

    CERN Document Server

    Suri, Niranjan

    2015-01-01

    As the complexity of today's networked computer systems grows, they become increasingly difficult to understand, predict, and control. Addressing these challenges requires new approaches to building these systems. Adaptive, Dynamic, and Resilient Systems supplies readers with various perspectives of the critical infrastructure that systems of networked computers rely on. It introduces the key issues, describes their interrelationships, and presents new research in support of these areas.The book presents the insights of a different group of international experts in each chapter. Reporting on r

  6. Dynamics of immune system vulnerabilities

    Science.gov (United States)

    Stromberg, Sean P.

    The adaptive immune system can be viewed as a complex system, which adapts, over time, to reflect the history of infections experienced by the organism. Understanding its operation requires viewing it in terms of tradeoffs under constraints and evolutionary history. It typically displays "robust, yet fragile" behavior, meaning common tasks are robust to small changes but novel threats or changes in environment can have dire consequences. In this dissertation we use mechanistic models to study several biological processes: the immune response, the homeostasis of cells in the lymphatic system, and the process that normally prevents autoreactive cells from entering the lymphatic system. Using these models we then study the effects of these processes interacting. We show that the mechanisms that regulate the numbers of cells in the immune system, in conjunction with the immune response, can act to suppress autoreactive cells from proliferating, thus showing quantitatively how pathogenic infections can suppress autoimmune disease. We also show that over long periods of time this same effect can thin the repertoire of cells that defend against novel threats, leading to an age correlated vulnerability. This vulnerability is shown to be a consequence of system dynamics, not due to degradation of immune system components with age. Finally, modeling a specific tolerance mechanism that normally prevents autoimmune disease, in conjunction with models of the immune response and homeostasis we look at the consequences of the immune system mistakenly incorporating pathogenic molecules into its tolerizing mechanisms. The signature of this dynamic matches closely that of the dengue virus system.

  7. Dynamical systems probabilistic risk assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Denman, Matthew R.; Ames, Arlo Leroy

    2014-03-01

    Probabilistic Risk Assessment (PRA) is the primary tool used to risk-inform nuclear power regulatory and licensing activities. Risk-informed regulations are intended to reduce inherent conservatism in regulatory metrics (e.g., allowable operating conditions and technical specifications) which are built into the regulatory framework by quantifying both the total risk profile as well as the change in the risk profile caused by an event or action (e.g., in-service inspection procedures or power uprates). Dynamical Systems (DS) analysis has been used to understand unintended time-dependent feedbacks in both industrial and organizational settings. In dynamical systems analysis, feedback loops can be characterized and studied as a function of time to describe the changes to the reliability of plant Structures, Systems and Components (SSCs). While DS has been used in many subject areas, some even within the PRA community, it has not been applied toward creating long-time horizon, dynamic PRAs (with time scales ranging between days and decades depending upon the analysis). Understanding slowly developing dynamic effects, such as wear-out, on SSC reliabilities may be instrumental in ensuring a safely and reliably operating nuclear fleet. Improving the estimation of a plant's continuously changing risk profile will allow for more meaningful risk insights, greater stakeholder confidence in risk insights, and increased operational flexibility.

  8. Dynamical systems probabilistic risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ames, Arlo Leroy [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-03-01

    Probabilistic Risk Assessment (PRA) is the primary tool used to risk-inform nuclear power regulatory and licensing activities. Risk-informed regulations are intended to reduce inherent conservatism in regulatory metrics (e.g., allowable operating conditions and technical specifications) which are built into the regulatory framework by quantifying both the total risk profile as well as the change in the risk profile caused by an event or action (e.g., in-service inspection procedures or power uprates). Dynamical Systems (DS) analysis has been used to understand unintended time-dependent feedbacks in both industrial and organizational settings. In dynamical systems analysis, feedback loops can be characterized and studied as a function of time to describe the changes to the reliability of plant Structures, Systems and Components (SSCs). While DS has been used in many subject areas, some even within the PRA community, it has not been applied toward creating long-time horizon, dynamic PRAs (with time scales ranging between days and decades depending upon the analysis). Understanding slowly developing dynamic effects, such as wear-out, on SSC reliabilities may be instrumental in ensuring a safely and reliably operating nuclear fleet. Improving the estimation of a plant's continuously changing risk profile will allow for more meaningful risk insights, greater stakeholder confidence in risk insights, and increased operational flexibility.

  9. Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells.

    Science.gov (United States)

    Yang, X; Nakao, Y; Pater, M M; Tang, S C; Pater, A

    1997-09-01

    We studied the molecular mechanism of successive multistep cervical carcinogenic progression with our previously established in vitro model system. This system was composed of primary human endocervical cells (HEN), two lines of HEN immortalized by HPV16 and their counterparts subsequently malignantly transformed by cigarette smoke condensate (CSC). The expression was examined of diverse cellular genes associated with oncogenesis and senescence, especially for cervical cancer. Consistent results were seen for the pairs of immortalized and malignantly transformed lines. Immortalization of HEN by HPV16 resulted in enhanced expression of H-ras, c-myc, B-myb, p53, p16INK4 and PCNA mRNA; enhanced expression of p16 and PCNA proteins; decreased expression of WAF1/p21/Cip1/Sid1 and fibronectin mRNA; and decreased p53 protein. On the other hand, the CSC-transformed counterparts of HPV16-immortalized cells had up-regulated levels of B-myb, p53 and WAF1 mRNA and p53 protein. Our results indicate that the differential activation or inactivation of multiple cellular genes is important for the immortalization, as well as the transformation, of human cervical cells. Further, we suggest that our in vitro model system is useful for investigating the molecular mechanism of multistep cervical carcinogenesis.

  10. Formal languages in dynamical systems

    CERN Document Server

    Troll, G

    1993-01-01

    We treat here the interrelation between formal languages and those dynamical systems that can be described by cellular automata (CA). There is a well-known injective map which identifies any CA-invariant subshift with a central formal language. However, in the special case of a symbolic dynamics, i.e. where the CA is just the shift map, one gets a stronger result: the identification map can be extended to a functor between the categories of symbolic dynamics and formal languages. This functor additionally maps topological conjugacies between subshifts to empty-string-limited generalized sequential machines between languages. If the periodic points form a dense set, a case which arises in a commonly used notion of chaotic dynamics, then an even more natural map to assign a formal language to a subshift is offered. This map extends to a functor, too. The Chomsky hierarchy measuring the complexity of formal languages can be transferred via either of these functors from formal languages to symbolic dynamics and p...

  11. Synchronization of nonautonomous dynamical systems

    Directory of Open Access Journals (Sweden)

    Peter E. Kloeden

    2003-04-01

    Full Text Available The synchronization of two nonautonomous dynamical systems is considered, where the systems are described in terms of a skew-product formalism, i. e., in which an inputed autonomous driving system governs the evolution of the vector field of a differential equation with the passage of time. It is shown that the coupled trajectories converge to each other as time increases for sufficiently large coupling coefficient and also that the component sets of the pullback attractor of the coupled system converges upper semi continuously as the coupling parameter increases to the diagonal of the product of the corresponding component sets of the pullback attractor of a system generated by the average of the vector fields of the original uncoupled systems.

  12. Hidden attractors in dynamical systems

    Science.gov (United States)

    Dudkowski, Dawid; Jafari, Sajad; Kapitaniak, Tomasz; Kuznetsov, Nikolay V.; Leonov, Gennady A.; Prasad, Awadhesh

    2016-06-01

    Complex dynamical systems, ranging from the climate, ecosystems to financial markets and engineering applications typically have many coexisting attractors. This property of the system is called multistability. The final state, i.e., the attractor on which the multistable system evolves strongly depends on the initial conditions. Additionally, such systems are very sensitive towards noise and system parameters so a sudden shift to a contrasting regime may occur. To understand the dynamics of these systems one has to identify all possible attractors and their basins of attraction. Recently, it has been shown that multistability is connected with the occurrence of unpredictable attractors which have been called hidden attractors. The basins of attraction of the hidden attractors do not touch unstable fixed points (if exists) and are located far away from such points. Numerical localization of the hidden attractors is not straightforward since there are no transient processes leading to them from the neighborhoods of unstable fixed points and one has to use the special analytical-numerical procedures. From the viewpoint of applications, the identification of hidden attractors is the major issue. The knowledge about the emergence and properties of hidden attractors can increase the likelihood that the system will remain on the most desirable attractor and reduce the risk of the sudden jump to undesired behavior. We review the most representative examples of hidden attractors, discuss their theoretical properties and experimental observations. We also describe numerical methods which allow identification of the hidden attractors.

  13. Dynamical Systems and Motion Vision.

    Science.gov (United States)

    1988-04-01

    TASK Artificial Inteligence Laboratory AREA I WORK UNIT NUMBERS 545 Technology Square . Cambridge, MA 02139 C\\ II. CONTROLLING OFFICE NAME ANO0 ADDRESS...INSTITUTE OF TECHNOLOGY ARTIFICIAL INTELLIGENCE LABORATORY A.I.Memo No. 1037 April, 1988 Dynamical Systems and Motion Vision Joachim Heel Abstract: In this... Artificial Intelligence L3 Laboratory of the Massachusetts Institute of Technology. Support for the Laboratory’s [1 Artificial Intelligence Research is

  14. Cosmological immortality: how to eliminate aging on a universal scale.

    Science.gov (United States)

    Vidal, Clement

    2014-01-01

    The death of our universe is as certain as our individual death. Some cosmologists have elaborated models which would make the cosmos immortal. In this paper, I examine them as cosmological extrapolations of immortality narratives that civilizations have developed to face death anxiety. I first show why cosmological death should be a worry, then I briefly examine scenarios involving the notion of soul or resurrection on a cosmological scale. I discuss in how far an intelligent civilization could stay alive by engaging in stellar, galactic and universal rejuvenation. Finally, I argue that leaving a cosmological legacy via universe making is an inspiring and promising narrative to achieve cosmological immortality.

  15. Dynamic security assessment processing system

    Science.gov (United States)

    Tang, Lei

    The architecture of dynamic security assessment processing system (DSAPS) is proposed to address online dynamic security assessment (DSA) with focus of the dissertation on low-probability, high-consequence events. DSAPS upgrades current online DSA functions and adds new functions to fit into the modern power grid. Trajectory sensitivity analysis is introduced and its applications in power system are reviewed. An index is presented to assess transient voltage dips quantitatively using trajectory sensitivities. Then the framework of anticipatory computing system (ACS) for cascading defense is presented as an important function of DSAPS. ACS addresses various security problems and the uncertainties in cascading outages. Corrective control design is automated to mitigate the system stress in cascading progressions. The corrective controls introduced in the dissertation include corrective security constrained optimal power flow, a two-stage load control for severe under-frequency conditions, and transient stability constrained optimal power flow for cascading outages. With state-of-the-art computing facilities to perform high-speed extended-term time-domain simulation and optimization for large-scale systems, DSAPS/ACS efficiently addresses online DSA for low-probability, high-consequence events, which are not addressed by today's industrial practice. Human interference is reduced in the computationally burdensome analysis.

  16. Network dynamics and systems biology

    Science.gov (United States)

    Norrell, Johannes A.

    The physics of complex systems has grown considerably as a field in recent decades, largely due to improved computational technology and increased availability of systems level data. One area in which physics is of growing relevance is molecular biology. A new field, systems biology, investigates features of biological systems as a whole, a strategy of particular importance for understanding emergent properties that result from a complex network of interactions. Due to the complicated nature of the systems under study, the physics of complex systems has a significant role to play in elucidating the collective behavior. In this dissertation, we explore three problems in the physics of complex systems, motivated in part by systems biology. The first of these concerns the applicability of Boolean models as an approximation of continuous systems. Studies of gene regulatory networks have employed both continuous and Boolean models to analyze the system dynamics, and the two have been found produce similar results in the cases analyzed. We ask whether or not Boolean models can generically reproduce the qualitative attractor dynamics of networks of continuously valued elements. Using a combination of analytical techniques and numerical simulations, we find that continuous networks exhibit two effects---an asymmetry between on and off states, and a decaying memory of events in each element's inputs---that are absent from synchronously updated Boolean models. We show that in simple loops these effects produce exactly the attractors that one would predict with an analysis of the stability of Boolean attractors, but in slightly more complicated topologies, they can destabilize solutions that are stable in the Boolean approximation, and can stabilize new attractors. Second, we investigate ensembles of large, random networks. Of particular interest is the transition between ordered and disordered dynamics, which is well characterized in Boolean systems. Networks at the

  17. Statistical Mechanics of Dynamical Systems

    Science.gov (United States)

    Mori, H.; Hata, H.; Horita, T.; Kobayashi, T.

    A statistical-mechanical formalism of chaos based on the geometry of invariant sets in phase space is discussed to show that chaotic dynamical systems can be treated by a formalism analogous to that of thermodynamic systems if one takes a relevant coarse-grained quantity, but their statistical laws are quite different from those of thermodynamic systems. This is a generalization of statistical mechanics for dealing with dissipative and hamiltonian (i.e., conservative) dynamical systems of a few degrees of freedom. Thus the sum of the local expansion rate of nearby orbits along relevant orbit over a long but finite time has been introduced in order to describe and characterize (1) a drastic change of the structure of a chaotic attractor at a bifurcation and anomalous phenomena associated, (2) a critical scaling of chaos in the neighborhood of a critical point for the bifurcation to a nonexotic state, and a self-similar temporal structure of a critical orbit on the critical 2^∞ attractor an the critical golden tori without mixing, (3) the critical KAM torus, diffusion and repeated sticking of a chaotic orbit to a critical torus in hamiltonian systems. Here a q-phase transition, analogous to the ferromagnetic phase transition, plays an important role. They are illustrated numerically and theoretically by treating the driven damped pendulum, the driven Duffing equation, the Henon map, and the dissipative and conservative standard maps. This description of chaos breaks the time-reversal symmetry of hamiltonian dynamical laws analogously to statistical mechanics of irreversible processes. The broken time-reversal symmetry is brought about by orbital instability of chaos.

  18. Survivability of Deterministic Dynamical Systems

    Science.gov (United States)

    Hellmann, Frank; Schultz, Paul; Grabow, Carsten; Heitzig, Jobst; Kurths, Jürgen

    2016-07-01

    The notion of a part of phase space containing desired (or allowed) states of a dynamical system is important in a wide range of complex systems research. It has been called the safe operating space, the viability kernel or the sunny region. In this paper we define the notion of survivability: Given a random initial condition, what is the likelihood that the transient behaviour of a deterministic system does not leave a region of desirable states. We demonstrate the utility of this novel stability measure by considering models from climate science, neuronal networks and power grids. We also show that a semi-analytic lower bound for the survivability of linear systems allows a numerically very efficient survivability analysis in realistic models of power grids. Our numerical and semi-analytic work underlines that the type of stability measured by survivability is not captured by common asymptotic stability measures.

  19. Structural Dynamics of Electronic Systems

    Science.gov (United States)

    Suhir, E.

    2013-03-01

    The published work on analytical ("mathematical") and computer-aided, primarily finite-element-analysis (FEA) based, predictive modeling of the dynamic response of electronic systems to shocks and vibrations is reviewed. While understanding the physics of and the ability to predict the response of an electronic structure to dynamic loading has been always of significant importance in military, avionic, aeronautic, automotive and maritime electronics, during the last decade this problem has become especially important also in commercial, and, particularly, in portable electronics in connection with accelerated testing of various surface mount technology (SMT) systems on the board level. The emphasis of the review is on the nonlinear shock-excited vibrations of flexible printed circuit boards (PCBs) experiencing shock loading applied to their support contours during drop tests. At the end of the review we provide, as a suitable and useful illustration, the exact solution to a highly nonlinear problem of the dynamic response of a "flexible-and-heavy" PCB to an impact load applied to its support contour during drop testing.

  20. Substitution dynamical systems spectral analysis

    CERN Document Server

    Queffélec, Martine

    2010-01-01

    This volume mainly deals with the dynamics of finitely valued sequences, and more specifically, of sequences generated by substitutions and automata. Those sequences demonstrate fairly simple combinatorical and arithmetical properties and naturally appear in various domains. As the title suggests, the aim of the initial version of this book was the spectral study of the associated dynamical systems: the first chapters consisted in a detailed introduction to the mathematical notions involved, and the description of the spectral invariants followed in the closing chapters. This approach, combined with new material added to the new edition, results in a nearly self-contained book on the subject. New tools - which have also proven helpful in other contexts - had to be developed for this study. Moreover, its findings can be concretely applied, the method providing an algorithm to exhibit the spectral measures and the spectral multiplicity, as is demonstrated in several examples. Beyond this advanced analysis, many...

  1. System dynamics in hydropower plants

    Energy Technology Data Exchange (ETDEWEB)

    Stuksrud, Dag Birger

    1998-12-31

    The main purpose of this thesis on system dynamics in hydropower plants was to establish new models of a hydropower system where the turbine/conduits and the electricity supply and generation are connected together as one unit such that possible interactions between the two power regimes can be studied. In order to describe the system dynamics as well as possible, a previously developed analytic model of high-head Francis turbines is improved. The model includes the acceleration resistance in the turbine runner and the draft tube. Expressions for the loss coefficients in the model are derived in order to obtain a purely analytic model. The necessity of taking the hydraulic inertia into account is shown by means of simulations. Unstable behaviour and a higher transient turbine speed than expected may occur for turbines with steep characteristics or large draft tubes. The turbine model was verified previously with respect to a high-head Francis turbine; the thesis performs an experimental verification on a low-head Francis turbine and compares the measurements with simulations from the improved turbine model. It is found that the dynamic turbine model is, after adjustment, capable of describing low-head machines as well with satisfying results. The thesis applies a method called the ``Limited zero-pole method`` to obtain new rational approximations of the elastic behaviour in the conduits with frictional damping included. These approximations are used to provide an accurate state space formulation of a hydropower plant. Simulations performed with the new computer programs show that hydraulic transients such as water-hammer and mass oscillations are reflected in the electric grid. Unstable governing performance in the electric and hydraulic parts also interact. This emphasizes the need for analysing the whole power system as a unit. 63 refs., 149 figs., 4 tabs.

  2. Multi-particle dynamical systems and polynomials

    Science.gov (United States)

    Demina, Maria V.; Kudryashov, Nikolai A.

    2016-05-01

    Polynomial dynamical systems describing interacting particles in the plane are studied. A method replacing integration of a polynomial multi-particle dynamical system by finding polynomial solutions of partial differential equations is introduced. The method enables one to integrate a wide class of polynomial multi-particle dynamical systems. The general solutions of certain dynamical systems related to linear second-order partial differential equations are found. As a by-product of our results, new families of orthogonal polynomials are derived.

  3. Dynamic information theory and information description of dynamic systems

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper, we develop dynamic statistical information theory established by the author. Starting from the ideas that the state variable evolution equations of stochastic dynamic systems, classical and quantum nonequilibrium statistical physical systems and special electromagnetic field systems can be regarded as their information symbol evolution equations and the definitions of dynamic information and dynamic entropy, we derive the evolution equations of dynamic information and dynamic entropy that describe the evolution laws of dynamic information. These four kinds of evolution equations are of the same mathematical type. They show in unison when information transmits in coordinate space outside the systems that the time rate of change of dynamic information densities originates from their drift, diffusion and dissipation in state variable space inside the systems and coordinate space in the transmission processes, and that the time rate of change of dynamic entropy densities is caused by their drift, diffusion and production in state variable space inside the systems and coordinate space in the transmission processes. When space noise can be neglected, an information wave will appear. If we only consider the information change inside the systems, dynamic information evolution equations reduce to information equations corresponding to the dynamic equations which describe evolution laws of the above dynamic systems. This reveals that the evolution laws of respective dynamic systems can be described by information equations in a unified fashion. Hence, the evolution processes of these dynamic systems can be abstracted as the evolution processes of information. Furthermore, we present the formulas for information flow, information dissipation rate, and entropy production rate. We prove that the information production probably emerges in a dynamic system with internal attractive interaction between the elements, and derive a formula for this information

  4. Power system dynamics and control

    CERN Document Server

    Kwatny, Harry G

    2016-01-01

    This monograph explores a consistent modeling and analytic framework that provides the tools for an improved understanding of the behavior and the building of efficient models of power systems. It covers the essential concepts for the study of static and dynamic network stability, reviews the structure and design of basic voltage and load-frequency regulators, and offers an introduction to power system optimal control with reliability constraints. A set of Mathematica tutorial notebooks providing detailed solutions of the examples worked-out in the text, as well as a package that will enable readers to work out their own examples and problems, supplements the text. A key premise of the book is that the design of successful control systems requires a deep understanding of the processes to be controlled; as such, the technical discussion begins with a concise review of the physical foundations of electricity and magnetism. This is followed by an overview of nonlinear circuits that include resistors, inductors, ...

  5. Cilia containing 9 + 2 structures grown from immortalized cells

    Institute of Scientific and Technical Information of China (English)

    Ming Zhang; Jose G Assouline

    2007-01-01

    Cilia depend on their highly differentiated structure, a 9 + 2 arrangement, to remove particles from the lung and to transport reproductive cells. Immortalized cells could potentially be of great use in cilia research. Immortalization of cells with cilia structure containing the 9 + 2 arrangement might be able to generate cell lines with such cilia structure. However, whether immortalized cells can retain such a highly differentiated structure remains unclear. Here we demonstrate that (1) using E1a gene transfection, tracheal cells are immortalized; (2) interestingly, in a gel culture the immortalized cells form spherical aggregations within which a lumen is developed; and (3) surprisingly, inside the aggregation, cilia containing a 9 + 2 arrangement grow from the cell's apical pole and protrude into the lumen. These results may influence future research in many areas such as understanding the mechanisms of cilia differentiation, cilia generation in other existing cell lines, cilia disorders, generation of other highly differentiated structures besides cilia using the gel culture,immortalization of other ciliated cells with the E1a gene, development of cilia motile function, and establishment of a research model to provide uniform ciliated cells.

  6. System dynamics for mechanical engineers

    CERN Document Server

    Davies, Matthew

    2015-01-01

    This textbook is ideal for mechanical engineering students preparing to enter the workforce during a time of rapidly accelerating technology, where they will be challenged to join interdisciplinary teams. It explains system dynamics using analogies familiar to the mechanical engineer while introducing new content in an intuitive fashion. The fundamentals provided in this book prepare the mechanical engineer to adapt to continuous technological advances with topics outside traditional mechanical engineering curricula by preparing them to apply basic principles and established approaches to new problems. This book also: ·         Reinforces the connection between the subject matter and engineering reality ·         Includes an instructor pack with the online publication that describes in-class experiments with minimal preparation requirements ·         Provides content dedicated to the modeling of modern interdisciplinary technological subjects, including opto-mechanical systems, high...

  7. Dynamics of complex quantum systems

    CERN Document Server

    Akulin, Vladimir M

    2014-01-01

    This book gathers together a range of similar problems that can be encountered in different fields of modern quantum physics and that have common features with regard to multilevel quantum systems. The main motivation was to examine from a uniform standpoint various models and approaches that have been developed in atomic, molecular, condensed matter, chemical, laser and nuclear physics in various contexts. The book should help senior-level undergraduate, graduate students and researchers putting particular problems in these fields into a broader scientific context and thereby taking advantage of well-established techniques used in adjacent fields. This second edition has been expanded to include substantial new material (e.g. new sections on Dynamic Localization and on Euclidean Random Matrices and new chapters on Entanglement, Open Quantum Systems, and Coherence Protection). It is based on the author’s lectures at the Moscow Institute of Physics and Technology, at the CNRS Aimé Cotton Laboratory, and on ...

  8. Topological dimension and dynamical systems

    CERN Document Server

    Coornaert, Michel

    2015-01-01

    Translated from the popular French edition, the goal of the book is to provide a self-contained introduction to mean topological dimension, an invariant of dynamical systems introduced in 1999 by Misha Gromov. The book examines how this invariant was successfully used by Elon Lindenstrauss and Benjamin Weiss to answer a long-standing open question about embeddings of minimal dynamical systems into shifts. A large number of revisions and additions have been made to the original text. Chapter 5 contains an entirely new section devoted to the Sorgenfrey line. Two chapters have also been added: Chapter 9 on amenable groups and Chapter 10 on mean topological dimension for continuous actions of countable amenable groups. These new chapters contain material that have never before appeared in textbook form. The chapter on amenable groups is based on Følner’s characterization of amenability and may be read independently from the rest of the book. Although the contents of this book lead directly to several active ar...

  9. Stability in dynamical systems I

    Energy Technology Data Exchange (ETDEWEB)

    Courant, E.D.; Ruth, R.D.; Weng, W.T.

    1984-08-01

    We have reviewed some of the basic techniques which can be used to analyze stability in nonlinear dynamical systems, particularly in circular particle accelerators. We have concentrated on one-dimensional systems in the examples in order to simply illustrate the general techniques. We began with a review of Hamiltonian dynamics and canonical transformations. We then reviewed linear equations with periodic coefficients using the basic techniques from accelerator theory. To handle nonlinear terms we developed a canonical perturbation theory. From this we calculated invariants and the amplitude dependence of the frequency. This led us to resonances. We studied the cubic resonance in detail by using a rotating coordinate system in phase space. We then considered a general isolated nonlinear resonance. In this case we calculated the width of the resonance and estimated the spacing of resonances in order to use the Chirikov criterion to restrict the validity of the analysis. Finally the resonance equation was reduced to the pendulum equation, and we examined the motion on a separatrix. This brought us to the beginnings of stochastic behavior in the neighborhood of the separatrix. It is this complex behavior in the neighborhood of the separatrix which causes the perturbation theory used here to diverge in many cases. In spite of this the methods developed here have been and are used quite successfully to study nonlinear effects in nearly integrable systems. When used with caution and in conjunction with numerical work they give tremendous insight into the nature of the phase space structure and the stability of nonlinear differential equations. 14 references.

  10. Chaos Cryptography with Dynamical Systems

    Science.gov (United States)

    Anderson, Robert; Morse, Jack; Schimmrigk, Rolf

    2001-11-01

    Cryptography is a subject that draws strength from an amazing variety of different mathematical fields, including such deep results as the Weil-Dwork-Deligne theorem on the zeta function. Physical theories have recently entered the subject as well, an example being the subject of quantum cryptography, motivated in part by Shor's insight into the vulnerability of prime number factorization based crypto systems. In this contribution we describe a cryptographic algorithm which is based on the dynamics of a class of physical models that exhibit chaotic behavior. More precisely, we consider dissipative systems which are described by nonlinear three-dimensional systems of differential equations with strange attractor surfaces of non-integer Lyapunov dimension. The time evolution of such systems in part of the moduli space shows unpredictable behavior, which suggests that they might be useful as pseudorandom number generators. We will show that this is indeed the case and illustrate our procedure mainly with the Lorenz attractor, though we also briefly mention the Rössler system. We use this class of nonlinear models to construct an extremely fast stream cipher with a large keyspace, which we test with Marsaglia's battery of DieHard tests.

  11. Nonlinear dynamics non-integrable systems and chaotic dynamics

    CERN Document Server

    Borisov, Alexander

    2017-01-01

    This monograph reviews advanced topics in the area of nonlinear dynamics. Starting with theory of integrable systems – including methods to find and verify integrability – the remainder of the book is devoted to non-integrable systems with an emphasis on dynamical chaos. Topics include structural stability, mechanisms of emergence of irreversible behaviour in deterministic systems as well as chaotisation occurring in dissipative systems.

  12. Uncertain dynamical systems defined by pseudomeasures

    Science.gov (United States)

    Hamm, Andreas

    1997-06-01

    This paper deals with uncertain dynamical systems in which predictions about the future state of a system are assessed by so-called pseudomeasures. Two special cases are stochastic dynamical systems, where the pseudomeasure is the conventional probability measure, and fuzzy dynamical systems in which the pseudomeasure is a so-called possibility measure. New results about possibilistic systems and their relation to deterministic and to stochastic systems are derived by using idempotent pseudolinear algebra. By expressing large deviation estimates for stochastic perturbations in terms of possibility measures, we obtain a new interpretation of the Freidlin-Wentzell quasipotentials for stochastic perturbations of dynamical systems as invariant possibility densities.

  13. Uncertain dynamical systems defined by pseudomeasures

    CERN Document Server

    Hamm, A

    1996-01-01

    This paper deals with uncertain dynamical systems in which predictions about the future state of a system are assessed by so called pseudomeasures. Two special cases are stochastic dynamical systems, where the pseudomeasure is the conventional probability measure, and fuzzy dynamical systems in which the pseudomeasure is a so called possibility measure. New results about possibilistic systems and their relation to deterministic and to stochastic systems are derived by using idempotent pseudolinear algebra. By expressing large deviation estimates for stochastic perturbations in terms of possibility measures, the Freidlin-Wentzell quasipotentials for stochastic perturbations of dynamical systems obtain a new interpretation as invariant possibility densities.

  14. A method for the immortalization of newborn mouse skin keratinocytes

    Directory of Open Access Journals (Sweden)

    Brianna O Hammiller

    2015-07-01

    Full Text Available Isolation and culture of mouse primary epidermal keratinocytes is a common technique that allows for easy genetic and environmental manipulation. However, due to their limited lifespan in culture, experiments utilizing primary keratinocytes require large numbers of animals, and are time consuming and expensive. To avoid these issues, we developed a method for the immortalization of primary mouse epidermal keratinocytes. Upon isolation of newborn epidermal keratinocytes according to established methods, the cells were cultured long-term in keratinocyte growth factor-containing medium. The cells senesced within a few weeks and eventually, small, slowly growing colonies emerged. After they regained confluency, the cells were passaged and slowly refilled the dish. With several rounds of subculture, the cells adapted to culture conditions, were easily subcultured, maintained normal morphology, and were apparently immortal. The immortalized cells retained the ability to differentiate with increased calcium concentrations, and were maintained to high passage numbers, while maintaining a relatively stable karyotype. Analysis of multiple immortalized cell lines as well as primary keratinocyte cultures, revealed increased numbers of chromosomes, especially in the primary keratinocytes, and chromosomal aberrations in most of the immortalized cultures and in the primary keratinocytes. Orthotopic grafting of immortalized keratinocytes together with fibroblasts onto nude mouse hosts produced skin while v-rasHa infection of the immortalized keratinocytes prior to grafting produced squamous cell carcinoma. In summary, this method of cell line generation allows for decreased use of animals, reduces the expense and time involved in research, and provides a useful model for cutaneous keratinocyte experimentation.

  15. Area Logistics System Based on System Dynamics Model

    Institute of Scientific and Technical Information of China (English)

    GUI Shouping; ZHU Qiang; LU Lifang

    2005-01-01

    At present, there are few effective ways to analyze area logistics systems. This paper uses system dynamics to analyze the area logistics system and establishes a system dynamics model for the area logistics system based on the characteristics of the area logistics system and system dynamics. Numerical simulations with the system dynamic model were used to analyze a logistic system. Analysis of the Guangzhou economy shows that the model can reflect the actual state of the system objectively and can be used to make policy and harmonize environment.

  16. Distributed Slicing in Dynamic Systems

    CERN Document Server

    Fernandez, Antonio; Jimenez, Ernesto; Kermarrec, Anne-Marie; Raynal, Michel

    2007-01-01

    Peer to peer (P2P) systems are moving from application specific architectures to a generic service oriented design philosophy. This raises interesting problems in connection with providing useful P2P middleware services capable of dealing with resource assignment and management in a large-scale, heterogeneous and unreliable environment. The slicing service, has been proposed to allow for an automatic partitioning of P2P networks into groups (slices) that represent a controllable amount of some resource and that are also relatively homogeneous with respect to that resource. In this paper we propose two gossip-based algorithms to solve the distributed slicing problem. The first algorithm speeds up an existing algorithm sorting a set of uniform random numbers. The second algorithm statistically approximates the rank of nodes in the ordering. The scalability, efficiency and resilience to dynamics of both algorithms rely on their gossip-based models. These algorithms are proved viable theoretically and experimenta...

  17. Dynamical systems of algebraic origin

    CERN Document Server

    Schmidt, Klaus

    1995-01-01

    Although much of classical ergodic theory is concerned with single transformations and one-parameter flows, the subject inherits from statistical mechanics not only its name, but also an obligation to analyze spatially extended systems with multidimensional symmetry groups. However, the wealth of concrete and natural examples which has contributed so much to the appeal and development of classical dynamics, is noticeably absent in this more general theory. The purpose of this book is to help remedy this scarcity of explicit examples by introducing a class of continuous Zd-actions diverse enough to exhibit many of the new phenomena encountered in the transition from Z to Zd, but which nevertheless lends itself to systematic study: the Zd-actions by automorphisms of compact, abelian groups. One aspect of these actions, not surprising in itself but quite striking in its extent and depth nonetheless, is the connection with commutative algebra and arithmetical algebraic geometry. The algebraic framework resulting...

  18. The GBT Dynamic Scheduling System

    Science.gov (United States)

    McCarty, M. T.; Balser, D. S.; Braatz, J.; Clark, M. H.; Condon, J.; Creager, R. E.; Maddalena, R. J.; Marganian, P.; O'Neil, K.; Sessoms, E.; Shelton, A. L.

    2012-09-01

    The Robert C. Byrd Green Bank Telescope (GBT) Dynamic Scheduling System (DSS), in use since September, 2009, was designed to maximize observing efficiency while preserving telescope flexibility and data quality without creating undue adversity for the observers. Using observing criteria; observer availability and qualifications for remote observing; three-dimensional weather forecasts; and telescope state, the DSS software optimally schedules observers 24 to 48 hours in advance for a telescope that has a wide-range of capabilities and a geographical location with variable weather patterns. The DSS project was closed October 28, 2011 and will now enter a continuing maintenance and enhancement phase. Recent improvements include a new resource calendar for incorporating telescope maintenance activities, a sensitivity calculator that leverages the scheduling algorithms to facilitate consistent tools for proposal preparation, improved support for monitoring observations, scheduling of high frequency continuum and spectral line observations for both sparse and fully sampled array receivers, and additional session parameters for observations having special requirements.

  19. Biofluid Dynamics in Cardiovascular System

    Science.gov (United States)

    Chung, Hansol; Yoo, Su Jung; Kyung, Richard

    2011-11-01

    Biofluid dynamics is characterized by the study of fluids in biological systems. Common biofluid systems include blood flow in the cardiovascular system and airflow in the lungs. The mathematical modeling of blood flow through the complex geometry of a prosthetic heart valve is a difficult task. In such a problem the complex geometries of the valve must be modeled properly so that they can be studied numerically. The present analysis is performed on a disk-type prosthetic heart valve. The valve is assumed to be in the aortic position and observed the structure of the valve cage influence the flow field near an aortic valve. For the purpose of mathematical modeling, the laminar incompressible two-dimensional steady flow of a homogeneous Newtonian fluid with constant viscosity is assumed. The flow is considered during the greater part of systole when the valve is fully open. Convergent numerical solutions are obtained for Reynolds numbers of 30, 180, 900 and 4500. Stream function, horizontal velocity, vertical velocity and shear stress solutions are computed at every grid point.

  20. Immortalized cells and one oncogene in malignant transformation: old insights on new explanation

    Science.gov (United States)

    2011-01-01

    Background Nearly thirty years ago, it was first shown that malignant transformation with single oncogene necessarily requires the immortal state of the cell. From that time this thesis for the cells of human origin was not disproved. The basic point which we want to focus on by this short communication is the correct interpretation of the results obtained on the widely used human embryonic kidney 293 (HEK293) cells. Results Intensive literature analysis revealed an increasing number of recent studies discovering new oncogenes with non-overlapping functions. Since the 1970s, dozens of oncogenes have been identified in human cancer. Cultured cell lines are often used as model systems in these experiments. In some investigations the results obtained on such cells are interpreted by the authors as a malignant transformation of normal animal or even normal human cells (as for example with HEK293 cells). However, when a cell line gains the ability to undergo continuous cell division, the cells are not normal any more, they are immortalized cells. Nevertheless, the authors consider these cells as normal human ones, what is basically incorrect. Moreover, it was early demonstrated that the widely used human embryonic kidney 293 (HEK293) cells have a relationship to neurons. Conclusions Thus, the experiments with established cell lines reinforce the notion that immortality is an essential requirement for malignant transformation that cooperates with other oncogenic changes to program the neoplastic state and substances under such investigation should be interpreted as factors which do not malignantly transform normal cells alone, but possess the ability to enhance the tumorigenic potential of already immortalized cells. PMID:21605454

  1. Variation, "evolution", immortality and genetic instabilities in tumour cells.

    Science.gov (United States)

    Bignold, L P

    2007-08-18

    The pathological characteristics of tumour cells often include variation of their histopathological features (i.e. "degrees of de-differentiation") between cases of the same tumour type and between different foci within individual tumours. Usually, only a few cell lines from tumours are immortal. Currently, somatic mutation, replicative infidelity of DNA and aneuploidy are suggested as alternative mechanisms of genomic disturbance underlying tumours. Nevertheless, apart from Hansemann's ideas of "anaplasia" and "de-differentiation" (proposed in the 1890s), and supposed "evolutionary themes" in cancer cell biology, little has been published concerning how histopathologic variation and immortality in tumour cells might arise. This paper reviews applications of the concepts of "variation" to tumours, including concepts of "evolution" and "cellular Darwinism". It is proposed that combinations of somatic mutation, DNA replicative infidelity and aneuploidy may explain the variabilities in tumours, and provide immortality in occasional tumour cells. A possible model involves (i) an initial somatic mutation causing reduced replicative fidelity of DNA, which could be variable in intensity, and thus give rise to variations between cases; (ii) a phase of replicative infidelity of DNA causing daughter cells lines to develop various abnormalities to different degrees, and hence provide for variation between areas of the same tumour. As a last event (iii) occasional asymmetric chromosomal distributions (aneuploidy) might "refresh" the ability of a daughter cell to replicate DNA faithfully causing them to become immortal. Thus extensively mutant and variable, hyperploid, and occasionally immortal cells might arise.

  2. Immortality of cell lines: challenges and advantages of establishment.

    Science.gov (United States)

    Maqsood, Muhammad Irfan; Matin, Maryam M; Bahrami, Ahmad Reza; Ghasroldasht, Mohammad M

    2013-10-01

    Cellular immortality happens upon impairment of cell-cycle checkpoint pathways (p53/p16/pRb), reactivation or up-regulation of telomerase enzyme, or upregulation of some oncogenes or oncoproteins leading to a higher rate of cell division.There are also some other factors and mechanisms involved in immortalisation, which need to be discovered. Immortalisation of cells derived from different sources and establishment of immortal cell lines has proven useful in understanding the molecular pathways governing cell developmental cascades in eukaryotic, especially human, cells. After the breakthrough of achieving the immortal cells and understanding their critical importance in the field of molecular biology, intense efforts have been dedicated to establish cell lines useful for elucidating the functions of telomerase, developmental lineage of progenitors, self-renewal potency, cellular transformation, differentiation patterns and some bioprocesses, like odontogenesis. Meanwhile, discovering the exact mechanisms of immortality, a major challenge for science yet, is believed to open new gateways toward understanding and treatment of cancer in the long term. This review summarises the methods involved in establishing immortality, its advantages and the challenges still being faced in this field. © 2013 International Federation for Cell Biology.

  3. Immortality in the Christian Physicalistic Theology: A Critical Survey

    Directory of Open Access Journals (Sweden)

    Hasan Ahmadizade

    2017-07-01

    Full Text Available Physicalistic Theology is a term that has no exact definition in theologian views. In the 20th century some of Christian thinkers on theology, like Nancy Murphy and Peter van Inwagen, by accepting a Physicalistic approach on human being, tried to analyze the Christian beliefs about human identity and his immortality. This approach today is called Physicalistic Theology. According to this approach, human is not but this physical body itself and so we can simply analyze the immortality problem. In this article we try to by an analytic and descriptive method, analyze the immortality of human according to the view of Physicalistic Theology. We will analyze the most important reasoning of Physicalistic Theology that is: no-interaction between the material and the immaterial, interaction between the person and the body, and the physicalism in Christian beliefs. One of the conclusions of this article is that according to Physicalistic view, the person that at some time has not been in the world, must exists any time to destroyed forever because the Christians believe to things that cannot justify rationally. The problem of immortality is one of these matters. Physicalistic Theology try to prove the immortality based on the miracles and the absolute power of God.

  4. On dynamic decoupling and dynamic path controllability in economic systems

    NARCIS (Netherlands)

    Nijmeijer, Henk

    1989-01-01

    In this paper the dynamic decouplability and dynamic path controllability of nonlinear discrete-time economic systems in state space form are discussed. Based on the observation that both properties are equivalent, a (theoretical) efficient way of target path controllability is proposed. This is ill

  5. Robust dissipativity for uncertain impulsive dynamical systems

    Directory of Open Access Journals (Sweden)

    Liu Bin

    2003-01-01

    Full Text Available We discuss the robust dissipativity with respect to the quadratic supply rate for uncertain impulsive dynamical systems. By employing the Hamilton-Jacobi inequality approach, some sufficient conditions of robust dissipativity for this kind of system are established. Finally, we specialize the obtained results to the case of uncertain linear impulsive dynamical systems.

  6. An Axiomatic Representation of System Dynamics

    CERN Document Server

    Baianu, I

    2004-01-01

    An axiomatic representation of system dynamics is introduced in terms of categories, functors, organismal supercategories, limits and colimits of diagrams. Specific examples are considered in Complex Systems Biology, such as ribosome biogenesis and Hormonal Control in human subjects. "Fuzzy" Relational Structures are also proposed for flexible representations of biological system dynamics and organization.

  7. The Piwi-piRNA pathway: road to immortality.

    Science.gov (United States)

    Sturm, Ádám; Perczel, András; Ivics, Zoltán; Vellai, Tibor

    2017-10-01

    Despite its medical, social, and economic significance, understanding what primarily causes aging, that is, the mechanisms of the aging process, remains a fundamental and fascinating problem in biology. Accumulating evidence indicates that a small RNA-based gene regulatory machinery, the Piwi-piRNA pathway, represents a shared feature of nonaging (potentially immortal) biological systems, including the germline, somatic cancer stem cells, and certain 'lower' eukaryotic organisms like the planarian flatworm and freshwater hydra. The pathway primarily functions to repress the activity of mobile genetic elements, also called transposable elements (TEs) or 'jumping genes', which are capable of moving from one genomic locus to another, thereby causing insertional mutations. TEs become increasingly active and multiply in the genomes of somatic cells as the organism ages. These characteristics of TEs highlight their decisive mutagenic role in the progressive disintegration of genetic information, a molecular hallmark associated with aging. Hence, TE-mediated genomic instability may substantially contribute to the aging process. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  8. Inducible immortality in hTERT-human mesenchymal stem cells.

    Science.gov (United States)

    Piper, Samantha L; Wang, Miqi; Yamamoto, Akira; Malek, Farbod; Luu, Andrew; Kuo, Alfred C; Kim, Hubert T

    2012-12-01

    Human mesenchymal stem cells (hMSCs) are attractive candidates for tissue engineering and cell-based therapy because of their multipotentiality and availability in adult donors. However, in vitro expansion and differentiation of these cells is limited by replicative senescence. The proliferative capacity of hMSCs can be enhanced by ectopic expression of telomerase, allowing for long-term culture. However, hMSCs with constitutive telomerase expression demonstrate unregulated growth and even tumor formation. To address this problem, we used an inducible Tet-On gene expression system to create hMSCs in which ectopic telomerase expression can be induced selectively by the addition of doxycycline (i-hTERT hMSCs). i-hTERT hMSCs have inducible hTERT expression and telomerase activity, and are able to proliferate significantly longer than wild type hMSCs when hTERT expression is induced. They stop proliferating when hTERT expression is turned off and can be rescued when expression is re-induced. They retain multipotentiality in vitro even at an advanced age. We also used a selective inhibitor of telomere elongation to show that the mechanism driving immortalization of hMSCs by hTERT is dependent upon maintenance of telomere length. Thanks to their extended lifespan, preserved multipotentiality and controlled growth, i-hTERT hMSCs may prove to be a useful tool for the development and testing of novel stem cell therapies. Copyright © 2012 Orthopaedic Research Society.

  9. hTERT-immortalized ovine microglia propagate natural scrapie isolates.

    Science.gov (United States)

    Muñoz-Gutiérrez, Juan F; Schneider, David A; Baszler, Timothy V; Greenlee, Justin J; Nicholson, Eric M; Stanton, James B

    2015-02-16

    Ex vivo propagation of natural prion isolates (i.e., propagated solely in the natural host) is crucial for the characterization and study of transmissible spongiform encephalopathies (TSEs). Several well-established, prion-permissive cell culture systems are available; however, only a few cell lines are permissive to natural prion isolates and these cells are not pathophysiologically relevant (e.g., renal epithelium and fibroblast-like cells). Therefore, a pathophysiologically relevant cell line derived from a natural TSE host could be used for propagation of natural prion isolates. In this study, ovine brain macrophages (microglia) were immortalized by transfection with the human telomerase reverse transcriptase (hTERT) gene to identify cell lines (hTERT-microglia) permissive to natural scrapie prion isolates. Following transfection, hTERT-microglia were passaged up to 100 times and their lifespan was significantly longer compared to parental cells (Fisher's exact test, Pscrapie isolates (i.e., derived from brain homogenates of sheep infected with scrapie). Prion infectivity and partial protease resistance of the prion protein were maintained in hTERT-microglia. Comparisons between scrapie-permissive and non-permissive hTERT-microglia sublines revealed that overall quantity of the normal cellular prion protein was not associated with prion permissiveness. The use of hTERT-microglia in future TSE studies may be more germane to the characterization of the cellular and subcellular pathophysiology of natural scrapie prion isolates and to investigate host-specific factors involved in prion replication.

  10. Hybrid Dynamical Systems Modeling, Stability, and Robustness

    CERN Document Server

    Goebel, Rafal; Teel, Andrew R

    2012-01-01

    Hybrid dynamical systems exhibit continuous and instantaneous changes, having features of continuous-time and discrete-time dynamical systems. Filled with a wealth of examples to illustrate concepts, this book presents a complete theory of robust asymptotic stability for hybrid dynamical systems that is applicable to the design of hybrid control algorithms--algorithms that feature logic, timers, or combinations of digital and analog components. With the tools of modern mathematical analysis, Hybrid Dynamical Systems unifies and generalizes earlier developments in continuous-time and discret

  11. In Vitro Endothelialization Test of Biomaterials Using Immortalized Endothelial Cells.

    Directory of Open Access Journals (Sweden)

    Ken Kono

    Full Text Available Functionalizing biomaterials with peptides or polymers that enhance recruitment of endothelial cells (ECs can reduce blood coagulation and thrombosis. To assess endothelialization of materials in vitro, primary ECs are generally used, although the characteristics of these cells vary among the donors and change with time in culture. Recently, primary cell lines immortalized by transduction of simian vacuolating virus 40 large T antigen or human telomerase reverse transcriptase have been developed. To determine whether immortalized ECs can substitute for primary ECs in material testing, we investigated endothelialization on biocompatible polymers using three lots of primary human umbilical vein endothelial cells (HUVEC and immortalized microvascular ECs, TIME-GFP. Attachment to and growth on polymer surfaces were comparable between cell types, but results were more consistent with TIME-GFP. Our findings indicate that TIME-GFP is more suitable for in vitro endothelialization testing of biomaterials.

  12. An optimization framework of biological dynamical systems.

    Science.gov (United States)

    Horie, Ryota

    2008-07-07

    Different biological dynamics are often described by different mathematical equations. On the other hand, some mathematical models describe many biological dynamics universally. Here, we focus on three biological dynamics: the Lotka-Volterra equation, the Hopfield neural networks, and the replicator equation. We describe these three dynamical models using a single optimization framework, which is constructed with employing the Riemannian geometry. Then, we show that the optimization structures of these dynamics are identical, and the differences among the three dynamics are only in the constraints of the optimization. From this perspective, we discuss the unified view for biological dynamics. We also discuss the plausible categorizations, the fundamental nature, and the efficient modeling of the biological dynamics, which arise from the optimization perspective of the dynamical systems.

  13. Attachment is a dynamic system

    Directory of Open Access Journals (Sweden)

    Zlatka Cugmas

    2003-04-01

    Full Text Available On the basis of the study of recent scientific literature about the development of attachment, the author answers the following questions: which are the postulates the theory of attachment has about the stability of the patterns of attachment, which level of stability in the patterns of attachment from infancy to adulthood these studies illuminate and which factors significantly influence the (instability of the patterns of attachment in time. The theory of attachment assumes that normal circumstances elicit stability. Changes, however, can be the result of important events influencing the sensitivity of the object of attachment. Agreement has not yet been reached regarding the percentage of stability in the patterns of attachment. There is more agreement regarding attachment in adulthood than that in childhood. The results depend on the size and characteristics of the subjects of the research, the measuring instruments, type of data analysis etc. The author concludes that attachment is a dynamic system influenced by significant changes in life (the cognitive development of the child, external care, parents' divorce, different stressful situations. As the influence of stressful events on the individual person' s quality of attachment is examined, it is necessary to consider also his/her temperamental characteristics, role of other people in their lives, etc.

  14. Genes involved in immortalization of human mammary cells

    Energy Technology Data Exchange (ETDEWEB)

    Stampfer, Martha R.; Yaswen, Paul

    2001-09-27

    Breast cancer progression is characterized by inappropriate cell growth. Normal cells cease growth after a limited number of cell divisions--a process called cellular senescence-while tumor cells may acquire the ability to proliferate indefinitely (immortality). Inappropriate expression of specific oncogenes in a key cellular signaling pathway (Ras, Raf) can promote tumorigenicity in immortal cells, while causing finite lifespan cells to undergo a rapid senescence-like arrest. We have studied when in the course of transformation of cultured human mammary epithelial cells (HMEC), the response to overexpressed oncogenic Raf changes from being tumor-suppressive to tumor enhancing, and what are the molecular underpinnings of this response. Our data indicate: (1) HMEC acquire the ability to maintain growth in the presence of oncogenic Raf not simply as a consequence of overcoming senescence, but as a result of a newly discovered step in the process of immortal transformation uncovered by our lab, termed conversion. Immortal cells that have not undergone conversion (e.g., cells immortalized by exogenous introduction of the immortalizing enzyme, telomerase) remain growth inhibited. (2) Finite lifespan HMEC growth arrest in response to oncogenic Raf using mediators of growth inhibition that are very different from those used in response to oncogenic Raf by rodent cells and certain other human cell types, including the connective tissue cells from the same breast tissue. While many diverse cell types appear to have in common a tumor-suppressive response to this oncogenic signal, they also have developed multiple mechanisms to elicit this response. Understanding how cancer cells acquire the crucial capacity to be immortal and to abrogate normal tumor-suppressive mechanisms may serve both to increase our understanding of breast cancer progression, and to provide new targets for therapeutic intervention. Our results indicate that normal HMEC have novel means of enforcing a Raf

  15. Dynamical systems generated by linear maps

    CERN Document Server

    Dolićanin, Ćemal B

    2014-01-01

    The book deals with dynamical systems, generated by linear mappings of finite dimensional spaces and their applications. These systems have a relatively simple structure from the point of view of the modern dynamical systems theory. However, for the dynamical systems of this sort, it is possible to obtain explicit answers to specific questions being useful in applications. The considered problems are natural and look rather simple, but in reality in the course of investigation, they confront users with plenty of subtle questions, and their detailed analysis needs a substantial effort. The problems arising are related to linear algebra and dynamical systems theory, and therefore, the book can be considered as a natural amplification, refinement and supplement to linear algebra and dynamical systems theory textbooks.

  16. Multibody system dynamics, robotics and control

    CERN Document Server

    Gerstmayr, Johannes

    2013-01-01

    The volume contains 19 contributions by international experts in the field of multibody system dynamics, robotics and control. The book aims to bridge the gap between the modeling of mechanical systems by means of multibody dynamics formulations and robotics. In the classical approach, a multibody dynamics model contains a very high level of detail, however, the application of such models to robotics or control is usually limited. The papers aim to connect the different scientific communities in multibody dynamics, robotics and control. Main topics are flexible multibody systems, humanoid robots, elastic robots, nonlinear control, optimal path planning, and identification.

  17. From Coupled Dynamical Systems to Biological Irreversibility

    OpenAIRE

    Kaneko, Kunihiko

    2002-01-01

    In the first half of the paper, some recent advances in coupled dynamical systems, in particular, a globally coupled map are surveyed. First, dominance of Milnor attractors in partially ordered phase is demonstrated. Second, chaotic itinerancy in high-dimensional dynamical systems is briefly reviewed, with discussion on a possible connection with a Milnor attractor network. Third, infinite-dimensional collective dynamics is studied, in the thermodynamic limit of the globally coupled map, wher...

  18. Electronic emulator of linear dynamic systems

    OpenAIRE

    Garan, Maryna; Kovalenko, Iaroslav; Moučka, Michal; Vagaská, Alena

    2015-01-01

    The aim of this article is development and realization of electronic emulator of dynamic systems with setting of parameters from PC. This emulator is the first prototype, which is meant to prove the possibility of emulating the behavior of dynamic systems by microprocessor. The main goal of research is creating of equipment, which can emulate a behavior of pneumatic muscle with sufficient accuracy. Dynamic of pneumatic muscles is significantly non-linear and changeable in the dependence on...

  19. Nonautonomous dynamical systems in the life sciences

    CERN Document Server

    Pötzsche, Christian

    2013-01-01

    Nonautonomous dynamics describes the qualitative behavior of evolutionary differential and difference equations, whose right-hand side is explicitly time dependent. Over recent years, the theory of such systems has developed into a highly active field related to, yet recognizably distinct from that of classical autonomous dynamical systems. This development was motivated by problems of applied mathematics, in particular in the life sciences where genuinely nonautonomous systems abound. The purpose of this monograph is to indicate through selected, representative examples how often nonautonomous systems occur in the life sciences and to outline the new concepts and tools from the theory of nonautonomous dynamical systems that are now available for their investigation.

  20. Stability Analysis of MEMS Gyroscope Dynamic Systems

    OpenAIRE

    M. Naser-Moghadasi; S. A. Olamaei; F. Setoudeh

    2013-01-01

    In this paper, the existence of a common quadratic Lyapunov function for stability analysis of MEMS Gyroscope dynamic systems has been studied then a new method based on stochastic stability of MEMS Gyroscope system has been proposed.

  1. Dynamic Simulation for Missile Erection System

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In order to study the dynamic characteristics of the missile erection system, it can be considered as a rigid-flexible coupling multi-body system. Firstly, the actual system is abstracted as an equal and simplified one and then the forces applied to it are analyzed. Secondly, the rigid-flexible coupling dynamic simulation for erection system is accomplished by use of the system simulation software, for example Pro/E, ADAMS, ANSYS, MATLAB/Simulink, etc. Finally, having the aid of simulation results, the kinetic and dynamic characteristics of the flexible bodies in erection system are analyzed.The simulation considering the erection system as a rigid-flexible coupling system can provide valuable results to the research of its kinetic, dynamic and vibrational characteristics.

  2. Semicontinuity of attractors for impulsive dynamical systems

    Science.gov (United States)

    Bonotto, E. M.; Bortolan, M. C.; Collegari, R.; Czaja, R.

    2016-10-01

    In this paper we introduce the concept of collective tube conditions which assures a suitable behaviour for a family of dynamical systems close to impulsive sets. Using the collective tube conditions, we develop the theory of upper and lower semicontinuity of global attractors for a family of impulsive dynamical systems.

  3. Narcissistic group dynamics of multiparty systems

    NARCIS (Netherlands)

    Schruijer, S.G.L.

    2015-01-01

    Purpose – This paper aims to introduce and illustrate the notion of narcissistic group dynamics. It is claimed that narcissism does not simply reside within individuals but can be characteristic of groups and social systems. In this case, the focus is on narcissistic dynamics in multiparty systems.

  4. Dynamic disturbance decoupling for nonlinear systems

    NARCIS (Netherlands)

    Huijberts, H.J.C.; Nijmeijer, H.; Wegen, van der L.L.M.

    1992-01-01

    In analogy with the dynamic input-output decoupling problem the dynamic disturbance decoupling problem for nonlinear systems is introduced. A local solution of this problem is obtained in the case that the system under consideration is invertible. The solution is given in algebraic as well as in geo

  5. About supramolecular systems for dynamically probing cells

    NARCIS (Netherlands)

    Brinkmann, J.; Cavatorta, E.; Sankaran, S.; Schmidt, B.; van Weerd, Jasper; Jonkheijm, Pascal

    2014-01-01

    This article reviews the state of the art in the development of strategies for generating supramolecular systems for dynamic cell studies. Dynamic systems are crucial to further our understanding of cell biology and are consequently at the heart of many medical applications. Increasing interest has

  6. Narcissistic group dynamics of multiparty systems

    NARCIS (Netherlands)

    Schruijer, S.G.L.

    2015-01-01

    Purpose – This paper aims to introduce and illustrate the notion of narcissistic group dynamics. It is claimed that narcissism does not simply reside within individuals but can be characteristic of groups and social systems. In this case, the focus is on narcissistic dynamics in multiparty systems.

  7. System dynamics modelling of situation awareness

    CSIR Research Space (South Africa)

    Oosthuizen, R

    2015-11-01

    Full Text Available . The feedback loops and delays in the Command and Control system also contribute to the complex dynamic behavior. This paper will build on existing situation awareness models to develop a System Dynamics model to support a qualitative investigation through...

  8. Classification of Dynamic Vehicle Routing Systems

    DEFF Research Database (Denmark)

    Larsen, Allan; Madsen, Oli B.G.; Solomon, Marius M.

    2007-01-01

    to classify dynamic vehicle routing systems. Methods for evaluation of the performance of algorithms that solve on-line routing problems are discussed and we list some of the most important issues to include in the system objective. Finally, we provide a three-echelon classification of dynamic vehicle routing...

  9. Logical entropy of quantum dynamical systems

    Directory of Open Access Journals (Sweden)

    Ebrahimzadeh Abolfazl

    2016-01-01

    Full Text Available This paper introduces the concepts of logical entropy and conditional logical entropy of hnite partitions on a quantum logic. Some of their ergodic properties are presented. Also logical entropy of a quantum dynamical system is dehned and ergodic properties of dynamical systems on a quantum logic are investigated. Finally, the version of Kolmogorov-Sinai theorem is proved.

  10. Dynamical systems on 2- and 3-manifolds

    CERN Document Server

    Grines, Viacheslav Z; Pochinka, Olga V

    2016-01-01

    This book provides an introduction to the topological classification of smooth structurally stable diffeomorphisms on closed orientable 2- and 3-manifolds.The topological classification is one of the main problems of the theory of dynamical systems and the results presented in this book are mostly for dynamical systems satisfying Smale's Axiom A. The main results on the topological classification of discrete dynamical systems are widely scattered among many papers and surveys. This book presents these results fluidly, systematically, and for the first time in one publication. Additionally, this book discusses the recent results on the topological classification of Axiom A diffeomorphisms focusing on the nontrivial effects of the dynamical systems on 2- and 3-manifolds. The classical methods and approaches which are considered to be promising for the further research are also discussed. < The reader needs to be familiar with the basic concepts of the qualitative theory of dynamical systems which are present...

  11. TRANSPLANTATION AND POTENTIAL IMMORTALITY OF MAMMALIAN TISSUES

    Science.gov (United States)

    Loeb, Leo

    1926-01-01

    1. Serial transplantation of tumors made it possible in 1901 and following years to draw the conclusion that various mammalian tissues have potential immortality. Serial transplantations of normal tissues did not succeed at first, because the homoioreaction on the part of the lymphocytes and connective tissue of the host injures the transplant. 2. In continuation of these experiments we found that cartilage of the rat can be transplanted serially to other rats at least for a period of 3 years. At the end of that time great parts of the transplanted cartilage and perichondrium are alive. 3. Not only the cartilage of young rats can be homoiotransplanted, but also the cartilage of very old rats which are nearing the end of life. By using such animals we have been able to obtain cartilage and perichondrium approaching an age of 6 years which is almost double the average age of a rat. 4. We found that cartilage can be homoiotransplanted more readily than other tissues for the following reasons: (a) While in principle the homoioreaction towards cartilage is the same as against other tissues, cartilage elicits this reaction with less intensity; (b) cartilage is better able to resist the invasion of lymphocytes and connective tissue than the majority of other tissues; (c) a gradual adaptation between transplant and host seems to take place in the case of cartilage transplantation, as a result of which the lymphocytic reaction on the part of the host tissue decreases progressively the longer the cartilage is kept in the strange host. 5. At time of examination we not only found living transplanted cartilage tissue, but also perichondrial tissue, which in response to a stimulus apparently originating in the necrotic central cartilage, had been proliferating and replacing it. These results suggest that it may perhaps be possible under favorable conditions to keep cartilage alive indefinitely through serial transplantations. 6. At the same time these experiments permit the

  12. Measuring an Individual's Investment in the Future: Symbolic Immortality, Sensation Seeking, and Psychic Numbness.

    Science.gov (United States)

    Mathews, Robert C.; Mister, Rena D.

    1988-01-01

    Operationalized Lifton's constructs of symbolic immortality and developed instrument to measure individual's needs for symbolic immortality in Lifton's five modes (biological, religious, nature, creative, experiential) in study which also examined age effects on needs for symbolic immortality and relation between sensation seeking and symbolic…

  13. Locus of Control and Level of Conflict as Correlates of Immortality Orientation.

    Science.gov (United States)

    O'Dowd, William

    1985-01-01

    Assessed the orientation of 14 male professors toward immortality as a psychological motive. Results showed a generally low conscious concern with immortality issues; however, respondents who have accepted some sort of immortality show a more internal locus of control and better adjustment. (JAC)

  14. Dynamics of vehicle-road coupled system

    CERN Document Server

    Yang, Shaopu; Li, Shaohua

    2015-01-01

    Vehicle dynamics and road dynamics are usually considered to be two largely independent subjects. In vehicle dynamics, road surface roughness is generally regarded as random excitation of the vehicle, while in road dynamics, the vehicle is generally regarded as a moving load acting on the pavement. This book suggests a new research concept to integrate the vehicle and the road system with the help of a tire model, and establishes a cross-subject research framework dubbed vehicle-pavement coupled system dynamics. In this context, the dynamics of the vehicle, road and the vehicle-road coupled system are investigated by means of theoretical analysis, numerical simulations and field tests. This book will be a valuable resource for university professors, graduate students and engineers majoring in automotive design, mechanical engineering, highway engineering and other related areas. Shaopu Yang is a professor and deputy president of Shijiazhuang Tiedao University, China; Liqun Chen is a professor at Shanghai Univ...

  15. Identification of dynamic systems, theory and formulation

    Science.gov (United States)

    Maine, R. E.; Iliff, K. W.

    1985-01-01

    The problem of estimating parameters of dynamic systems is addressed in order to present the theoretical basis of system identification and parameter estimation in a manner that is complete and rigorous, yet understandable with minimal prerequisites. Maximum likelihood and related estimators are highlighted. The approach used requires familiarity with calculus, linear algebra, and probability, but does not require knowledge of stochastic processes or functional analysis. The treatment emphasizes unification of the various areas in estimation in dynamic systems is treated as a direct outgrowth of the static system theory. Topics covered include basic concepts and definitions; numerical optimization methods; probability; statistical estimators; estimation in static systems; stochastic processes; state estimation in dynamic systems; output error, filter error, and equation error methods of parameter estimation in dynamic systems, and the accuracy of the estimates.

  16. Transcribing the balanced scorecard into system dynamics

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    2013-01-01

    the cause-and-effect relationships of an integrated BSC model. Including dynamic aspects of BSCs into the discussion is only in its infancy, so the aim of our work is also to contribute to both scholars’ and practitioners’ general understanding of how such delayed dynamic effects propagate through system......The purpose of this paper is to show how a System Dynamics Modelling approach can be integrated into the Balanced Scorecard (BSC) for a case company with special focus on the handling of causality in a dynamic perspective. The BSC model includes five perspectives and a number of financial and non...

  17. Symbolic Immortality in Ordinary Contexts: Impediments to the Nuclear Era.

    Science.gov (United States)

    Schmitt, Raymond L.

    1982-01-01

    Lifton's writings indicate that fear of nuclear holocaust has severely impaired and threatens to negate traditional modes of symbolic immortality in America. Lifton's research, however, has been limited to extreme contexts. Data were triangulated in four distinctive American contexts. Found substantial negative evidence of Lifton's suspicions in…

  18. The Golden Bough: Literature and the Idea of Immortality.

    Science.gov (United States)

    Klotz, Kenneth

    1979-01-01

    All works of literature reflect man's obsession with death and his creative attempts to evade or postpone it. Art cannot solve the problem, but within the limits of human capabilities, we come to art, whether as artists or audience, for our own small share in the "intimations of immortality." (Author/SJL)

  19. The French Academy: Arbitrator of Taste, Order, Genius--Immortality.

    Science.gov (United States)

    Buzash, Michael D.

    The French Academy is the oldest of the scholarly societies of France. Its ideals and preferences of order, genius, and immortality have influenced the schools, conservatories, universities, and archives and the intellectual and artistic tastes of the time. Its foundation was laid by nine lettered, well-educated laymen and ecclesiastics around…

  20. Dynamical systems, attractors, and neural circuits.

    Science.gov (United States)

    Miller, Paul

    2016-01-01

    Biology is the study of dynamical systems. Yet most of us working in biology have limited pedagogical training in the theory of dynamical systems, an unfortunate historical fact that can be remedied for future generations of life scientists. In my particular field of systems neuroscience, neural circuits are rife with nonlinearities at all levels of description, rendering simple methodologies and our own intuition unreliable. Therefore, our ideas are likely to be wrong unless informed by good models. These models should be based on the mathematical theories of dynamical systems since functioning neurons are dynamic-they change their membrane potential and firing rates with time. Thus, selecting the appropriate type of dynamical system upon which to base a model is an important first step in the modeling process. This step all too easily goes awry, in part because there are many frameworks to choose from, in part because the sparsely sampled data can be consistent with a variety of dynamical processes, and in part because each modeler has a preferred modeling approach that is difficult to move away from. This brief review summarizes some of the main dynamical paradigms that can arise in neural circuits, with comments on what they can achieve computationally and what signatures might reveal their presence within empirical data. I provide examples of different dynamical systems using simple circuits of two or three cells, emphasizing that any one connectivity pattern is compatible with multiple, diverse functions.

  1. Dynamical System Approaches to Combinatorial Optimization

    DEFF Research Database (Denmark)

    Starke, Jens

    2013-01-01

    Several dynamical system approaches to combinatorial optimization problems are described and compared. These include dynamical systems derived from penalty methods; the approach of Hopfield and Tank; self-organizing maps, that is, Kohonen networks; coupled selection equations; and hybrid methods....... Many of them are investigated analytically, and the costs of the solutions are compared numerically with those of solutions obtained by simulated annealing and the costs of a global optimal solution. Using dynamical systems, a solution to the combinatorial optimization problem emerges in the limit...... of large times as an asymptotically stable point of the dynamics. The obtained solutions are often not globally optimal but good approximations of it. Dynamical system and neural network approaches are appropriate methods for distributed and parallel processing. Because of the parallelization...

  2. Dynamical systems revisited : Hybrid systems with Zeno executions

    OpenAIRE

    ZHANG, JUN; Johansson, Karl Henrik; Lygeros, John; Sastry, Shankar

    2000-01-01

    Results from classical dynamical systems are generalized to hybrid dynamical systems. The concept of omega limit set is introduced for hybrid systems and is used to prove new results on invariant sets and stability, where Zeno and non-Zeno hybrid systems can be treated within the same framework. As an example, LaSalle's Invariance Principle is extended to hybrid systems. Zeno hybrid systems are discussed in detail. The omega limit set of a Zeno execution is characterized for classes of hybrid...

  3. Component Based Dynamic Reconfigurable Test System

    Institute of Scientific and Technical Information of China (English)

    LAI Hong; HE Lingsong; ZHANG Dengpan

    2006-01-01

    In this paper, a novel component based framework of test system is presented for the new requirements of dynamic changes of test functions and reconfiguration of test resources. The complexity of dynamic reconfiguration arises from the scale, redirection, extensibility and interconnection of components in test system. The paper is started by discussing the component assembly based framework which provide the open platform to the deploy of components and then the script interpreter model is introduced to dynamically create the components and build the test system by analyzing XML based information of test system. A pipeline model is presented to provide the data channels and behavior reflection among the components. Finally, a dynamic reconfigurable test system is implemented on the basis of COM and applied in the remote test and control system of CNC machine.

  4. Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake.

    Science.gov (United States)

    Kemp, Sarah J; Thorley, Andrew J; Gorelik, Julia; Seckl, Michael J; O'Hare, Michael J; Arcaro, Alexandre; Korchev, Yuri; Goldstraw, Peter; Tetley, Teresa D

    2008-11-01

    Primary human alveolar type 2 (AT2) cells were immortalized by transduction with the catalytic subunit of telomerase and simian virus 40 large-tumor antigen. Characterization by immunochemical and morphologic methods demonstrated an AT1-like cell phenotype. Unlike primary AT2 cells, immortalized cells no longer expressed alkaline phosphatase, pro-surfactant protein C, and thyroid transcription factor-1, but expressed increased caveolin-1 and receptor for advanced glycation end products (RAGE). Live cell imaging using scanning ion conductance microscopy showed that the cuboidal primary AT2 cells were approximately 15 microm and enriched with surface microvilli, while the immortal AT1 cells were attenuated more than 40 microm, resembling these cells in situ. Transmission electron microscopy highlighted the attenuated morphology and showed endosomal vesicles in some immortal AT1 cells (but not primary AT2 cells) as found in situ. Particulate air pollution exacerbates cardiopulmonary disease. Interaction of ultrafine, nano-sized particles with the alveolar epithelium and/or translocation into the cardiovasculature may be a contributory factor. We hypothesized differential uptake of nanoparticles by AT1 and AT2 cells, depending on particle size and surface charge. Uptake of 50-nm and 1-microm fluorescent latex particles was investigated using confocal microscopy and scanning surface confocal microscopy of live cells. Fewer than 10% of primary AT2 cells internalized particles. In contrast, 75% immortal AT1 cells internalized negatively charged particles, while less than 55% of these cells internalized positively charged particles; charge, rather than size, mattered. The process was rapid: one-third of the total cell-associated negatively charged 50-nm particle fluorescence measured at 24 hours was internalized during the first hour. AT1 cells could be important in translocation of particles from the lung into the circulation.

  5. Partial Dynamical Symmetry in Nuclear Systems

    Energy Technology Data Exchange (ETDEWEB)

    Escher, J E

    2003-06-02

    Partial dynamical symmetry (PDS) extends and complements the concepts of exact and dynamical symmetry. It allows one to remove undesired constraints from an algebraic theory, while preserving some of the useful aspects of a dynamical symmetry, and to study the effects of symmetry breaking in a controlled manner. An example of a PDS in an interacting fermion system is presented. The associated PDS Hamiltonians are closely related with a realistic quadrupole-quadrupole interaction and provide new insights into this important interaction.

  6. Dynamic Double Curvature Mould System

    DEFF Research Database (Denmark)

    Jepsen, Christian Raun; Kristensen, Mathias Kræmmergaard; Kirkegaard, Poul Henning

    2011-01-01

    The present paper describes a concept for a reconfigurable mould surface which is designed to fit the needs of contemporary architecture. The core of the concept presented is a dynamic surface manipulated into a given shape using a digital signal created directly from the CAD drawing of the design...

  7. Expectations of immortality: dam safety management into the next millennium

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, M.D. [Tonkin and Taylor International Ltd., Auckland, (New Zealand)

    1999-07-01

    Topics concerning the problems associated with older and aging dams are considered including: what can be done to extent the lifetime of an old dam, the decision to decommission a dam based on a value judgment that the risk of maintaining the dam is too great for society's acceptance, the possibility of change in the level of risk tolerance with time in a technological environment, traditional surveillance methods used by dam owners in the Y2K situation, and the unreality of dam immortality. Trends and means for preserving older dams for their owner's purposes are outlined, as well as their lifetime compared to that of the downstream systems they serve. Despite the fact that we live in a throwaway society, dam owners cannot just leave their dam asset when they are through with using it. Someone has to maintain the dam, or ensure that it is safely decommissioned when the owner is finished with it. On a worldwide scale the available pool of experienced dam engineers is shrinking. This problem needs to be addressed by a shift towards operating and dam safety management skills based on a firm awareness of dam design principles. A shift in society's expectations has occurred such that dam designers and owners must now recognize the impact a dam can have both on its natural and social environments. Because of the increasing emphasis on paying attention to the impacts of people's activities on the planet, engineers more than anyone else must have a significant influence in that direction. 9 refs.

  8. Modeling the Dynamics of an Information System

    Directory of Open Access Journals (Sweden)

    Jacek Unold

    2003-11-01

    Full Text Available The article concentrates on the nature of a social subsystem of an information system. It analyzes the nature of information processes of collectivity within an IS and introduces a model of IS dynamics. The model is based on the assumption that a social subsystem of an information system works as a nonlinear dynamic system. The model of IS dynamics is verified on the indexes of the stock market. It arises from the basic assumption of the technical analysis of the markets, that is, the index chart reflects the play of demand and supply, which in turn represents the crowd sentiment on the market.

  9. SIAM conference on applications of dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    A conference (Oct.15--19, 1992, Snowbird, Utah; sponsored by SIAM (Society for Industrial and Applied Mathematics) Activity Group on Dynamical Systems) was held that highlighted recent developments in applied dynamical systems. The main lectures and minisymposia covered theory about chaotic motion, applications in high energy physics and heart fibrillations, turbulent motion, Henon map and attractor, integrable problems in classical physics, pattern formation in chemical reactions, etc. The conference fostered an exchange between mathematicians working on theoretical issues of modern dynamical systems and applied scientists. This two-part document contains abstracts, conference program, and an author index.

  10. Planar dynamical systems selected classical problems

    CERN Document Server

    Liu, Yirong; Huang, Wentao

    2014-01-01

    This book presents in an elementary way the recent significant developments in the qualitative theory of planar dynamical systems. The subjects are covered as follows: the studies of center and isochronous center problems, multiple Hopf bifurcations and local and global bifurcations of the equivariant planar vector fields which concern with Hilbert's 16th problem. This book is intended for graduate students, post-doctors and researchers in the area of theories and applications of dynamical systems. For all engineers who are interested the theory of dynamical systems, it is also a reasona

  11. Dynamic stability experiment of Maglev systems

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Y.; Mulcahy, T.M.; Chen, S.S. [and others

    1995-04-01

    This report summarizes the research performed on Maglev vehicle dynamic stability at Argonne National Laboratory during the past few years. It also documents magnetic-force data obtained from both measurements and calculations. Because dynamic instability is not acceptable for any commercial Maglev system, it is important to consider this phenomenon in the development of all Maglev systems. This report presents dynamic stability experiments on Maglev systems and compares their numerical simulation with predictions calculated by a nonlinear dynamic computer code. Instabilities of an electrodynamic system (EDS)-type vehicle model were obtained from both experimental observations and computer simulations for a five-degree-of-freedom Maglev vehicle moving on a guideway consisting of double L-shaped aluminum segments attached to a rotating wheel. The experimental and theoretical analyses developed in this study identify basic stability characteristics and future research needs of Maglev systems.

  12. Dynamics of mechanical systems with variable mass

    CERN Document Server

    Belyaev, Alexander

    2014-01-01

    The book presents up-to-date and unifying formulations for treating dynamics of different types of mechanical systems with variable mass. The starting point is overview of the continuum mechanics relations of balance and jump for open systems from which extended Lagrange and Hamiltonian formulations are derived. Corresponding approaches are stated at the level of analytical mechanics with emphasis on systems with a position-dependent mass and at the level of structural mechanics. Special emphasis is laid upon axially moving structures like belts and chains, and on pipes with an axial flow of fluid. Constitutive relations in the dynamics of systems with variable mass are studied with particular reference to modeling of multi-component mixtures. The dynamics of machines with a variable mass are treated in detail and conservation laws and the stability of motion will be analyzed. Novel finite element formulations for open systems in coupled fluid and structural dynamics are presented.

  13. Coherent regimes of globally coupled dynamical systems

    DEFF Research Database (Denmark)

    de Monte, Silvia; D'ovidio, Francesco; Mosekilde, Erik

    2003-01-01

    This Letter presents a method by which the mean field dynamics of a population of dynamical systems with parameter diversity and global coupling can be described in terms of a few macroscopic degrees of freedom. The method applies to populations of any size and functional form in the region...

  14. Parallelized implementation of dynamical particle system

    Science.gov (United States)

    Mašek, Jan; Frantík, Petr; Vořechovský, Miroslav

    2017-07-01

    The paper presents approaches to implementation of solution of discrete dynamical system of mutually repelling particles. Two platforms: a single-thread JAVA process and parallelized CUDA C solution, are employed for the dynamical simulation. Qualities of both platforms are discussed and explained as their performance when solving two proposed interaction laws is compared.

  15. SV40TAg和Cre/loxP系统诱导的正常人可逆性转化黑素细胞在豚鼠体内的存活能力和复色实验%Survival and melanogenic potential of reversibly immortalized human melanocytes mediated by SV40T antigen gene and Cre/loxP system in Guinea pigs

    Institute of Scientific and Technical Information of China (English)

    王鹰; 曾志华; 杨希川; 郝飞; 钟白玉

    2010-01-01

    目的 研究SV40TAg基因和Cre/loxP系统在体外诱导正常人黑素细胞的可逆性转化以及转化细胞在豚鼠体内的存活能力和复色效果.方法 用Cre-ER~(T2)病毒上清感染经SV40TAg基因转化的正常人黑素细胞(MCT),诱导Cre重组酶表达(MCTC);过氧化氢法建立黄褐色雄性豚鼠白癜风动物模型,按黑素细胞移植方法进行原代黑素细胞和MCTC移植,观察MCTC在豚鼠体内的存活能力及复色效果.结果 MCTC细胞移植实验结果显示,1个月左右移植区即可见色素沉着,连续观察3个月,可见0.5~1 cm的黑色斑片或褐色斑片形成,移植成功率为82.5%,原代黑素细胞移植成功率为76.7%.病理观察移植区有明显黑素沉积,部分毛囊内也可见黑素沉积.结论 联合应用SV40TAg基因和Cre/loxP系统可以成功地诱导具有良好生物学安全性的人源性可逆性永生化黑素细胞,具有与原代黑素细胞相似的在体存活率,具备在体黑素合成功能,可以达到良好的复色效果.%Objective To study the survival and melanogenic potential of human melanocytes reversibly immortalized via SV40T antigen gene and Cre/loxP system in Guinea pigs. Methods The supernatants of retrovirus vector Cre-ERT2 were used to infect melanocytes which had been successfully transfected by SV40TAg gene (MCT), then the expression of Cre recombinase was induced with tamoxifen in infected cells; subsequently, the surviving cells, which were named as MCTC, were subjected to expansion culture. Guinea pigs were utilized to establish animal models of vitiligo, then MCTC and primary melanocytes were transplanted respectively into the animal models. The repigmentation at the transplanted area was observed with naked eyes successively until 3 months after the transplantation when tissue samples were obtained from implanted area and nonimplanted area of guinea pigs and subjected to Masson-Fontana silver stain and Hematoxylin-eosin stain for the analysis of

  16. Introduction to Chaotic Dynamical Systems

    Science.gov (United States)

    1992-12-01

    independent eigenvectors. The details can be found in Borrelli-Coleman [Ref. 2] and Boyce - DiPrima [Ref. 5]. The c, are determined once an initial...constructed using techniques described in Boyce - DiPrima [Ref. 5]. These "generalized- eigenvectors are placed in the appropriate eigenspace depending...Oscillations. DYnamical SY51emns. and flhtircations I4 er, Fields. Springer-NVerlag. 1 983. 5. Bovce. Williamn E.. and Richard C. DiPrima . Elementarv

  17. Neural circuits as computational dynamical systems.

    Science.gov (United States)

    Sussillo, David

    2014-04-01

    Many recent studies of neurons recorded from cortex reveal complex temporal dynamics. How such dynamics embody the computations that ultimately lead to behavior remains a mystery. Approaching this issue requires developing plausible hypotheses couched in terms of neural dynamics. A tool ideally suited to aid in this question is the recurrent neural network (RNN). RNNs straddle the fields of nonlinear dynamical systems and machine learning and have recently seen great advances in both theory and application. I summarize recent theoretical and technological advances and highlight an example of how RNNs helped to explain perplexing high-dimensional neurophysiological data in the prefrontal cortex.

  18. Solved problems in dynamical systems and control

    CERN Document Server

    Tenreiro-Machado, J; Valério, Duarte; Galhano, Alexandra M

    2016-01-01

    This book presents a collection of exercises on dynamical systems, modelling and control. Each topic covered includes a summary of the theoretical background, problems with solutions, and further exercises.

  19. Retrovirus-Mediated Gene Transfer in Immortalization of Progenitor Hair Cell Lines in Newborn Rat

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yuan; ZHAI Suo-qiang; SONG Wei; GUO Wei; ZHENG Gui-liang; HU Yin-yan

    2008-01-01

    Objective To present an experimental method that allows isolation of greater epithelial ridge (GER) and lesser epithelial ridge(LER) cells from postnatal rat cochleae using a combinatorial approach of enzymatic digestion and mechanical separation and to investigate a retrovirus-mediated gene transfer technique for its possibl utility in immortalization of the GER and LER cell lines, in an effort to establish an in vitro model system of hair cell differentiation. Methods GER and LER cells were dissected from postnatal rat cochleae and immortalized by transferring the SV40 large T antigen using a retrovirus. The established cell lines were confirmed through morphology observation, immunnocytochemical staining and RT-PCR analysis. The Hathl gene was transferred into the cell lines using adenovirus-mediated techniques to explore their potential to differentiate into hair cells. Results The established cell lines were stably maintained for more than 20 passages and displayed many features similar to primary GER and LER cells. They grew in patches and assumed a polygonal morphology. Immunostaining showed labeling by SV40 large T antigen and Islet1 (a specific marker for GER and LER). All passages of the cell lines expressed SV40 large T antigen on RT-PCR analysis. The cells also showed the capability to differenti-ate into hair cell-like cells when forced to express Hathl. Conclusion Retrovirus-mediated gene transfer can be used in establishing immortalized progenitor hair cell lines in newborn rat, which may provide an invaluable system for studying hair cell differentiation and regeneration for new treatment of sensory hearing loss caused by hair cell loss.

  20. Dynamic Response Analysis of Motorized Spindle System

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; LUO Yi-chao; XU Juan; XIAO Ru-feng; LI Xian-hui

    2013-01-01

    As to motorized spindle system, this paper builds a simplified 3D model of spindle and bearing, performs structure modal analysis, reveals its dynamic characteristics under the free model;furthermore, modifies bearing radial stiffness and number of model, and studies the change of modal parameters. On this basis, through the harmonic response analysis of the finite element model, dy-namic response characteristic caused by imbalance of monitored spindle system and law of vibration response to different amount of unbalance is analyzed.

  1. Multidimensional dynamical systems accepting the normal shift

    CERN Document Server

    Boldin, A Y

    1994-01-01

    The dynamical systems of the form \\ddot\\bold r=\\bold F (\\bold r,\\dot\\bold r) in \\Bbb R^n accepting the normal shift are considered. The concept of weak normality for them is introduced. The partial differential equations for the force field \\bold F(\\bold r,\\dot\\bold r) of the dynamical systems with weak and complete normality are derived.

  2. Dynamics and Controls in Maglev Systems

    Science.gov (United States)

    1992-09-01

    and Alscher, H. 1986. "The Magnetic Train Transrapid 06," Proc. Int. Conf. Maglev and Linear Drives, May 14-16, 1986, Vancouver, B.C., Canada, Publ. by...AD-A263 087 ANL-92/43It Il~l Iif IIt[11 Materials and Components Dynamics and Controls Technology Division Materials and Components in Maglev ...Argonne, Illinois 60439 Distribution Category: All Transportation Systems Reports (UC-330) Dynamics and Controls in Maglev Systems by Y. Cai and S. S

  3. Uncertainty Quantification in Hybrid Dynamical Systems

    CERN Document Server

    Sahai, Tuhin

    2011-01-01

    Uncertainty quantification (UQ) techniques are frequently used to ascertain output variability in systems with parametric uncertainty. Traditional algorithms for UQ are either system-agnostic and slow (such as Monte Carlo) or fast with stringent assumptions on smoothness (such as polynomial chaos and Quasi-Monte Carlo). In this work, we develop a fast UQ approach for hybrid dynamical systems by extending the polynomial chaos methodology to these systems. To capture discontinuities, we use a wavelet-based Wiener-Haar expansion. We develop a boundary layer approach to propagate uncertainty through separable reset conditions. We also introduce a transport theory based approach for propagating uncertainty through hybrid dynamical systems. Here the expansion yields a set of hyperbolic equations that are solved by integrating along characteristics. The solution of the partial differential equation along the characteristics allows one to quantify uncertainty in hybrid or switching dynamical systems. The above method...

  4. Uncertainty quantification in hybrid dynamical systems

    Science.gov (United States)

    Sahai, Tuhin; Pasini, José Miguel

    2013-03-01

    Uncertainty quantification (UQ) techniques are frequently used to ascertain output variability in systems with parametric uncertainty. Traditional algorithms for UQ are either system-agnostic and slow (such as Monte Carlo) or fast with stringent assumptions on smoothness (such as polynomial chaos and Quasi-Monte Carlo). In this work, we develop a fast UQ approach for hybrid dynamical systems by extending the polynomial chaos methodology to these systems. To capture discontinuities, we use a wavelet-based Wiener-Haar expansion. We develop a boundary layer approach to propagate uncertainty through separable reset conditions. We also introduce a transport theory based approach for propagating uncertainty through hybrid dynamical systems. Here the expansion yields a set of hyperbolic equations that are solved by integrating along characteristics. The solution of the partial differential equation along the characteristics allows one to quantify uncertainty in hybrid or switching dynamical systems. The above methods are demonstrated on example problems.

  5. Identification and Modelling of Linear Dynamic Systems

    Directory of Open Access Journals (Sweden)

    Stanislav Kocur

    2006-01-01

    Full Text Available System identification and modelling are very important parts of system control theory. System control is only as good as good is created model of system. So this article deals with identification and modelling problems. There are simple classification and evolution of identification methods, and then the modelling problem is described. Rest of paper is devoted to two most known and used models of linear dynamic systems.

  6. Dynamics and control of technical systems

    CERN Document Server

    Balthazar, José M; Kaczmarczyk, Stefan

    2014-01-01

    The main topics of this Special Issue are linear and, mainly, nonlinear dynamics, chaos and control of systems and structures and their applications in different field of science and engineering. According to the goal of the Special Issue, the selected contributions are divided into three major parts: ""Vibration Problems in Vertical Transportation Systems"", ""Nonlinear Dynamics, Chaos and Control of Elastic Structures"" and ""New Strategies and Challenges for Aerospace and Ocean Structures Dynamics and Control"". The discussion of real problems in aerospace and how these problems can be unde

  7. Dynamical systems examples of complex behaviour

    CERN Document Server

    Jost, Jürgen

    2005-01-01

    Our aim is to introduce, explain, and discuss the fundamental problems, ideas, concepts, results, and methods of the theory of dynamical systems and to show how they can be used in speci?c examples. We do not intend to give a comprehensive overview of the present state of research in the theory of dynamical systems, nor a detailed historical account of its development. We try to explain the important results, often neglecting technical re?nements 1 and, usually, we do not provide proofs. One of the basic questions in studying dynamical systems, i.e. systems that evolve in time, is the construction of invariants that allow us to classify qualitative types of dynamical evolution, to distinguish between qualitatively di?erent dynamics, and to studytransitions between di?erent types. Itis also important to ?nd out when a certain dynamic behavior is stable under small perturbations, as well as to understand the various scenarios of instability. Finally, an essential aspect of a dynamic evolution is the transformat...

  8. Dynamics of Propellant Feedline Systems

    Science.gov (United States)

    1987-05-01

    45 5-15 Prgram results using Euler’s method (x=813 m, L=3048 m, a=981 ms, D-0.61 m, Qo=0 .89 m 3/s, Uv=-10.06 m) 47 5-16 Program results using forward...was the constant pressure reservoir at the downstream end. The con- ditions here were evaluated by substituting the known pressure once more into Eq...et al. LOX Suction Duct Dynamic Evaluation , D13339, Sumnary of Test Results. The Boeing Company Report D5-14061, May 1970. 19. Simpson, A. R. and E. B

  9. Detecting recurrence domains of dynamical systems by symbolic dynamics.

    Science.gov (United States)

    beim Graben, Peter; Hutt, Axel

    2013-04-12

    We propose an algorithm for the detection of recurrence domains of complex dynamical systems from time series. Our approach exploits the characteristic checkerboard texture of recurrence domains exhibited in recurrence plots. In phase space, recurrence plots yield intersecting balls around sampling points that could be merged into cells of a phase space partition. We construct this partition by a rewriting grammar applied to the symbolic dynamics of time indices. A maximum entropy principle defines the optimal size of intersecting balls. The final application to high-dimensional brain signals yields an optimal symbolic recurrence plot revealing functional components of the signal.

  10. Dynamical evolution of planetary systems

    CERN Document Server

    Morbidelli, Alessandro

    2011-01-01

    The apparent regularity of the motion of the giant planets of our solar system suggested for decades that said planets formed onto orbits similar to the current ones and that nothing dramatic ever happened during their lifetime. The discovery of extra-solar planets showed astonishingly that the orbital structure of our planetary system is not typical. Many giant extra-solar planets have orbits with semi major axes of $\\sim 1$ AU, and some have even smaller orbital radii, sometimes with orbital periods of just a few days. Moreover, most extra-solar planets have large eccentricities, up to values that only comets have in our solar system. Why such a big diversity between our solar system and the extra-solar systems, as well as among the extra-solar systems themselves? This chapter aims to give a partial answer to this fundamental question....

  11. Dynamic modeling of solar dynamic components and systems

    Science.gov (United States)

    Hochstein, John I.; Korakianitis, T.

    1992-09-01

    The purpose of this grant was to support NASA in modeling efforts to predict the transient dynamic and thermodynamic response of the space station solar dynamic power generation system. In order to meet the initial schedule requirement of providing results in time to support installation of the system as part of the initial phase of space station, early efforts were executed with alacrity and often in parallel. Initially, methods to predict the transient response of a Rankine as well as a Brayton cycle were developed. Review of preliminary design concepts led NASA to select a regenerative gas-turbine cycle using a helium-xenon mixture as the working fluid and, from that point forward, the modeling effort focused exclusively on that system. Although initial project planning called for a three year period of performance, revised NASA schedules moved system installation to later and later phases of station deployment. Eventually, NASA selected to halt development of the solar dynamic power generation system for space station and to reduce support for this project to two-thirds of the original level.

  12. Dynamic control of the space tethered system

    Science.gov (United States)

    Malashin, A. A.; Smirnov, N. N.; Bryukvina, O. Yu.; Dyakov, P. A.

    2017-02-01

    We discuss the problem of simultaneous dynamical stabilization and suppression of transverse and longitudinal vibrations of the space tethered system deployed along a certain trajectory. The dynamics of the system is described by a system of nonlinear partial differential equations for the longitudinal and transverse waves and we consider a non-classical version of the problem with one moving boundary. We formulate a mathematical model and perform the analytic and numerical analysis of the boundary control problem based on the Lyapunov method. A scheme of the deployment mechanism is suggested. It includes a control torque and transverse displacement of the boundary and ensures stable deployment of the whole system.

  13. Dynamic Properties of Impulse Measuring Systems

    DEFF Research Database (Denmark)

    Pedersen, A.; Lausen, P.

    1971-01-01

    After some basic considerations the dynamic properties of the measuring system are subjected to a general examination based on a number of responses, characteristic of the system. It is demonstrated that an impulse circuit has an internal impedance different from zero, for which reason the intera......After some basic considerations the dynamic properties of the measuring system are subjected to a general examination based on a number of responses, characteristic of the system. It is demonstrated that an impulse circuit has an internal impedance different from zero, for which reason...

  14. Fuzzy system dynamics and optimization with application to manpower systems

    Directory of Open Access Journals (Sweden)

    C. Mbohwa

    2012-10-01

    Full Text Available The dynamics of human resource recruitment and training in an uncertain environment creates a challenge for many policy makers in various organisations. In the presence of fuzzy manpower demand and training capacity, many companies fear losing critical human resources when their employees leave. As such, the development of effective dynamic policies for recruitment and training in a fuzzy dynamic environment is imperative. In this frame of mind, a fuzzy systems dynamics modelling approach is proposed to enable the policy maker to develop reliable dynamic policies relating recruitment, training, and available skills, from a systems perspective. It is anticipated in this study that fuzzy system dynamics and optimization approach would help organizations to design effective manpower policies and strategies.

  15. Dynamic memory management for embedded systems

    CERN Document Server

    Atienza Alonso, David; Poucet, Christophe; Peón-Quirós, Miguel; Bartzas, Alexandros; Catthoor, Francky; Soudris, Dimitrios

    2015-01-01

    This book provides a systematic and unified methodology, including basic principles and reusable processes, for dynamic memory management (DMM) in embedded systems.  The authors describe in detail how to design and optimize the use of dynamic memory in modern, multimedia and network applications, targeting the latest generation of portable embedded systems, such as smartphones. Coverage includes a variety of design and optimization topics in electronic design automation of DMM, from high-level software optimization to microarchitecture-level hardware support. The authors describe the design of multi-layer dynamic data structures for the final memory hierarchy layers of the target portable embedded systems and how to create a low-fragmentation, cost-efficient, dynamic memory management subsystem out of configurable components for the particular memory allocation and de-allocation patterns for each type of application.  The design methodology described in this book is based on propagating constraints among de...

  16. System dynamics an introduction for mechanical engineers

    CERN Document Server

    Seeler, Karl A

    2014-01-01

    This essential textbook takes the student from the initial steps in modeling a dynamic system through development of the mathematical models needed for feedback control.  The generously-illustrated, student-friendly text focuses on fundamental theoretical development rather than the application of commercial software.  Practical details of machine design are included to motivate the non-mathematically inclined student. This book also: Emphasizes the linear graph method for modeling dynamic systems Offers a systematic approach for creating an engineering model, extracting information, and formulating mathematical analyses Adopts a unifying theme of power flow as the dynamic agent that eases analysis of hybrid systems, such as machinery Presents differential equations as dynamic operators and stresses input/output relationships Introduces Mathcad and programming in MATLAB Allows for use of Open Source Computational Software (R or C) Features over 1000 illustrations

  17. Geometry and stability of dynamical systems

    CERN Document Server

    Punzi, Raffaele

    2008-01-01

    We reconsider both the global and local stability of solutions of continuously evolving dynamical systems from a geometric perspective. We clarify that an unambiguous definition of stability generally requires the choice of additional geometric structure that is not intrinsic to the dynamical system itself. While global Lyapunov stability is based on the choice of seminorms on the vector bundle of perturbations, we propose a definition of local stability based on the choice of a linear connection. We show how this definition reproduces known stability criteria for second order dynamical systems. In contrast to the general case, the special geometry of Lagrangian systems provides completely intrinsic notions of global and local stability. We demonstrate that these do not suffer from the limitations occurring in the analysis of the Maupertuis-Jacobi geodesics associated to natural Lagrangian systems.

  18. Immortalization of human articular chondrocytes and induction of their phenotype

    Institute of Scientific and Technical Information of China (English)

    何清义; 李起鸿; 杨柳; 许建中

    2003-01-01

    Objective To immortalize human articular chondrocytes (HACs) using gene transfection and to maintain stable phenotype of transformed HACs after induction.Methods HACs were transfected with the retroviral vector pLXSN encoding human papillomavirus 16E7 (HPV16E7), and the transformed clones were sorted and proliferated. Karyotype analysis, clone forming tests and nude mice tumor forming tests were applied to check the characteristics of the transformation. Type Ⅱ collagen of transformed chondrocytes was inducted with free serum medium (FSM) supplemented with nutridoma-sp and ascorbate. Results Immortalized HACs were isolated with fifty passages achieved. The HPV16E7 transformed cells were confirmed to be benign. Induction of FSM with nutridoma-sp and ascorbate promoted type Ⅱ collagen of transformed chondrocytes to the high levels of normal chondrocytes. Conclusion HACs transformed with HPV16E7 survive for long periods in vitro, and type Ⅱ collagen can maintain stability after induction.

  19. Dynamics of Multibody Systems Near Lagrangian Points

    Science.gov (United States)

    Wong, Brian

    This thesis examines the dynamics of a physically connected multi-spacecraft system in the vicinity of the Lagrangian points of a Circular Restricted Three-Body System. The spacecraft system is arranged in a wheel-spoke configuration with smaller and less massive satellites connected to a central hub using truss/beams or tether connectors. The kinematics of the system is first defined, and the kinetic, gravitational potential energy and elastic potential energy of the system are derived. The Assumed Modes Method is used to discretize the continuous variables of the system, and a general set of ordinary differential equations describing the dynamics of the connectors and the central hub are obtained using the Lagrangian method. The flexible body dynamics of the tethered and truss connected systems are examined using numerical simulations. The results show that these systems experienced only small elastic deflections when they are naturally librating or rotating at moderate angular velocities, and these deflections have relatively small effect on the attitude dynamics of the systems. Based on these results, it is determined that the connectors can be modeled as rigid when only the attitude dynamics of the system is of interest. The equations of motion of rigid satellites stationed at the Lagrangian points are linearized, and the stability conditions of the satellite are obtained from the linear equations. The required conditions are shown to be similar to those of geocentric satellites. Study of the linear equations also revealed the resonant conditions of rigid Lagrangian point satellites, when a librational natural frequency of the satellite matches the frequency of its station-keeping orbit leading to large attitude motions. For tethered satellites, the linear analysis shows that the tethers are in stable equilibrium when they lie along a line joining the two primary celestial bodies of the Three-Body System. Numerical simulations are used to study the long term

  20. Hybrid dynamical systems observation and control

    CERN Document Server

    Defoort, Michael

    2015-01-01

    This book is a collection of contributions defining the state of current knowledge and new trends in hybrid systemssystems involving both continuous dynamics and discrete events – as described by the work of several well-known groups of researchers. Hybrid Dynamical Systems presents theoretical advances in such areas as diagnosability, observability and stabilization for various classes of system. Continuous and discrete state estimation and self-triggering control of nonlinear systems are advanced. The text employs various methods, among them, high-order sliding modes, Takagi–Sugeno representation and sampled-data switching to achieve its ends. The many applications of hybrid systems from power converters to computer science are not forgotten; studies of flexible-joint robotic arms and – as representative biological systems – the behaviour of the human heart and vasculature, demonstrate the wide-ranging practical significance of control in hybrid systems. The cross-disciplinary origins of study ...

  1. Differential gene expression in SV40-mediated immortalization of human fibroblasts.

    Science.gov (United States)

    Pardinas, J; Pang, Z; Houghton, J; Palejwala, V; Donnelly, R J; Hubbard, K; Small, M B; Ozer, H L

    1997-06-01

    Normal human diploid fibroblasts (HF) have a limited life span, undergo senescence, and rarely, if ever, spontaneously immortalize in culture. Introduction of the gene for T antigen encoded by the DNA virus SV40 extends the life span of HF and increases the frequency of immortalization; however, immortalization requires both T-dependent and T-independent functions. We previously generated independent SV40-transformed non-immortal (pre-immortal) HF cell lines from which we then obtained immortal sublines as part of a multifaceted approach to identify functions responsible for immortalization. In this study we undertook a search for cellular mRNAs which are differentially expressed upon immortalization. A lambda cDNA library was prepared from a pre-immortal SV40-transformed HF (HF-C). We screened the library with a subtracted probe enriched for sequences present in HF-C and reduced in immortal AR5 cells. A more limited screen was also employed for sequences overexpressed in AR5 using a different strategy. Alterations in the level of mRNAs in AR5 encoding functions relevant to signal transduction pathways were identified; however, most cDNAs encoded novel sequences. In an effort to clarify which of the altered mRNAs are most relevant to immortalization, we performed Northern analysis with RNA prepared from three paired sets of independent pre-immortal and immortal (4 cell lines) SV40-transformants using eight cloned cDNAs which show reduced expression in AR5. Three of these were reduced in additional immortal cell lines as well; one, J4-4 (unknown function) is reduced in all the immortal cell lines tested; a second, J4-3 (possible PP2C type phosphatase) is reduced in 2 of the 3 matched sets; and a third, J2-2 (unknown function) is reduced in 2 unrelated immortal cell lines. Although the roles of these genes are as yet unclear, their further analysis should extend our understanding of the molecular bases for immortalization. In particular, the patterns of expression of

  2. Nonlinear dynamics in distributed systems

    CERN Document Server

    Adjali, I; Gell-Mann, Murray; Iqbal Adjali; Jose-Luis Fernandez-Villacanas; Michael Gell

    1994-01-01

    formulate it in a way that the deterministic and stochastic processes within the system are clearly separable. We show how internal fluctuations can be analysed in a systematic way using Van Kanpen's expansion method for Markov processes. We present some results for both stationary and time-dependent states. Our approach allows the effect of fluctuations to be explored, particularly in finite systems where such processes assume increasing importance.

  3. Ontology of Earth's nonlinear dynamic complex systems

    Science.gov (United States)

    Babaie, Hassan; Davarpanah, Armita

    2017-04-01

    As a complex system, Earth and its major integrated and dynamically interacting subsystems (e.g., hydrosphere, atmosphere) display nonlinear behavior in response to internal and external influences. The Earth Nonlinear Dynamic Complex Systems (ENDCS) ontology formally represents the semantics of the knowledge about the nonlinear system element (agent) behavior, function, and structure, inter-agent and agent-environment feedback loops, and the emergent collective properties of the whole complex system as the result of interaction of the agents with other agents and their environment. It also models nonlinear concepts such as aperiodic, random chaotic behavior, sensitivity to initial conditions, bifurcation of dynamic processes, levels of organization, self-organization, aggregated and isolated functionality, and emergence of collective complex behavior at the system level. By incorporating several existing ontologies, the ENDCS ontology represents the dynamic system variables and the rules of transformation of their state, emergent state, and other features of complex systems such as the trajectories in state (phase) space (attractor and strange attractor), basins of attractions, basin divide (separatrix), fractal dimension, and system's interface to its environment. The ontology also defines different object properties that change the system behavior, function, and structure and trigger instability. ENDCS will help to integrate the data and knowledge related to the five complex subsystems of Earth by annotating common data types, unifying the semantics of shared terminology, and facilitating interoperability among different fields of Earth science.

  4. Stressed SIRT7: facing a crossroad of senescence and immortality.

    Science.gov (United States)

    Liu, Jun-Ping; Chen, Ruping

    2015-06-01

    SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality. © 2015 Wiley Publishing Asia Pty Ltd.

  5. Koschei the immortal and anti-aging drugs.

    Science.gov (United States)

    Blagosklonny, M V

    2014-12-04

    In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.

  6. Koschei the immortal and anti-aging drugs

    Science.gov (United States)

    Blagosklonny, M V

    2014-01-01

    In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors. PMID:25476900

  7. Nonequilibrium quantum dynamics in optomechanical systems

    Science.gov (United States)

    Patil, Yogesh Sharad; Cheung, Hil F. H.; Shaffer, Airlia; Wang, Ke; Vengalattore, Mukund

    2016-05-01

    The thermalization dynamics of isolated quantum systems has so far been explored in the context of cold atomic systems containing a large number of particles and modes. Quantum optomechanical systems offer prospects of studying such dynamics in a qualitatively different regime - with few individually addressable modes amenable to continuous quantum measurement and thermalization times that vastly exceed those observed in cold atomic systems. We have experimentally realized a dynamical continuous phase transition in a quantum compatible nondegenerate mechanical parametric oscillator. This system is formally equivalent to the optical parametric amplifiers whose dynamics have been a subject of intense theoretical study. We experimentally verify its phase diagram and observe nonequilibrium behavior that was only theorized, but never directly observed, in the context of optical parametric amplifiers. We discuss prospects of using nonequilibrium protocols such as quenches in optomechanical systems to amplify weak nonclassical correlations and to realize macroscopic nonclassical states. This work was supported by the DARPA QuASAR program through a Grant from the ARO and the ARO MURI on non-equilibrium manybody dynamics.

  8. The data system dynamic simulation /DSDS/

    Science.gov (United States)

    Hooper, J. W.; Piner, J. R.

    1978-01-01

    The paper describes the development by NASA of the data system dynamic simulation (DSDS) which provides a data system simulation capability for a broad range of programs, with the capability to model and simulate all or any portion of an end-to-end data system to multiple levels of fidelity. Versatility is achieved by specifying parameters which define the performance characteristics of data system components, and by specifying control and data paths in a data system. DSDS helps reduce overall simulation cost and the time required for obtaining a data systems analysis, and helps provide both early realistic representations of data systems and the flexibility to study design changes and operating strategies.

  9. Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study.

    Directory of Open Access Journals (Sweden)

    Yim Ling Yip

    Full Text Available Nasopharyngeal carcinoma (NPC is common among southern Chinese including the ethnic Cantonese population living in Hong Kong. Epstein-Barr virus (EBV infection is detected in all undifferentiated type of NPC in this endemic region. Establishment of stable and latent EBV infection in premalignant nasopharyngeal epithelial cells is an early event in NPC development and may contribute to its pathogenesis. Immortalized primary nasopharyngeal epithelial cells represent an important tool for investigation of EBV infection and its tumorigenic potential in this special type of epithelial cells. However, the limited availability and small sizes of nasopharyngeal biopsies have seriously restricted the establishment of primary nasopharyngeal epithelial cells for immortalization. A reliable and effective method to immortalize primary nasopharyngeal epithelial cells will provide unrestricted materials for EBV infection studies. An earlier study has reported that Bmi-1 expression could immortalize primary nasopharyngeal epithelial cells. However, its efficiency and actions in immortalization have not been fully characterized. Our studies showed that Bmi-1 expression alone has limited ability to immortalize primary nasopharyngeal epithelial cells and additional events are often required for its immortalization action. We have identified some of the key events associated with the immortalization of primary nasopharyngeal epithelial cells. Efficient immortalization of nasopharyngeal epithelial cells could be reproducibly and efficiently achieved by the combined actions of Bmi-1 expression, activation of telomerase and silencing of p16 gene. Activation of MAPK signaling and gene expression downstream of Bmi-1 were detected in the immortalized nasopharyngeal epithelial cells and may play a role in immortalization. Furthermore, these newly immortalized nasopharyngeal epithelial cells are susceptible to EBV infection and supported a type II latent EBV infection

  10. Transcription profiles of non-immortalized breast cancer cell lines

    Directory of Open Access Journals (Sweden)

    Holland James F

    2006-04-01

    Full Text Available Abstract Background Searches for differentially expressed genes in tumours have made extensive use of array technology. Most samples have been obtained from tumour biopsies or from established tumour-derived cell lines. Here we compare cultures of non-immortalized breast cancer cells, normal non-immortalized breast cells and immortalized normal and breast cancer cells to identify which elements of a defined set of well-known cancer-related genes are differentially expressed. Methods Cultures of cells from pleural effusions or ascitic fluids from breast cancer patients (MSSMs were used in addition to commercially-available normal breast epithelial cells (HMECs, established breast cancer cell lines (T-est and established normal breast cells (N-est. The Atlas Human Cancer 1.2 cDNA expression array was employed. The data obtained were analysed using widely-available statistical and clustering software and further validated through real-time PCR. Results According to Significance Analysis of Microarray (SAM and AtlasImage software, 48 genes differed at least 2-fold in adjusted intensities between HMECs and MSSMs (p Conclusion The expression profiles of 1176 genes were determined in finite life-span cultures of metastatic breast cancer cells and of normal breast cells. Significant differences were detected between the finite life-span breast cancer cell cultures and the established breast cancer cell lines. These data suggest caution in extrapolating information from established lines for application to clinical cancer research.

  11. Immortalization of human normal and NF1 neurofibroma Schwann cells.

    Science.gov (United States)

    Li, Hua; Chang, Lung-Ji; Neubauer, Debbie R; Muir, David F; Wallace, Margaret R

    2016-10-01

    Neurofibromas, which are benign Schwann cell tumors, are the hallmark feature in the autosomal dominant condition neurofibromatosis 1 (NF1) and are associated with biallelic loss of NF1 gene function. There is a need for effective therapies for neurofibromas, particularly the larger, plexiform neurofibromas. Tissue culture is an important tool for research. However, it is difficult to derive enriched human Schwann cell cultures, and most enter replicative senescence after 6-10 passages, impeding cell-based research in NF1. Through exogenous expression of human telomerase reverse transcriptase and murine cyclin-dependent kinase (mCdk4), normal (NF1 wild-type), neurofibroma-derived Schwann cells heterozygous for NF1 mutation, and neurofibroma-derived Schwann cells homozygous for NF1 mutation were immortalized, including some matched samples from the same NF1 patient. Initial experiments employed retroviral vectors, while subsequent work utilized lentiviral vectors carrying these genes because of improved efficiency. Expression of both transgenes was required for immortalization. Molecular and immunohistochemical analysis indicated that these cell lines are of Schwann cell lineage and have a range of phenotypes, many of which are consistent with their primary cultures. This is the first report of immortalization and detailed characterization of multiple human NF1 normal nerve and neurofibroma-derived Schwann cell lines, which will be highly useful research tools to study NF1 and other Schwann tumor biology and conditions.

  12. Biomechanics of Posterior Dynamic Stabilization Systems

    Directory of Open Access Journals (Sweden)

    D. U. Erbulut

    2013-01-01

    Full Text Available Spinal rigid instrumentations have been used to fuse and stabilize spinal segments as a surgical treatment for various spinal disorders to date. This technology provides immediate stability after surgery until the natural fusion mass develops. At present, rigid fixation is the current gold standard in surgical treatment of chronic back pain spinal disorders. However, such systems have several drawbacks such as higher mechanical stress on the adjacent segment, leading to long-term degenerative changes and hypermobility that often necessitate additional fusion surgery. Dynamic stabilization systems have been suggested to address adjacent segment degeneration, which is considered to be a fusion-associated phenomenon. Dynamic stabilization systems are designed to preserve segmental stability, to keep the treated segment mobile, and to reduce or eliminate degenerative effects on adjacent segments. This paper aimed to describe the biomechanical aspect of dynamic stabilization systems as an alternative treatment to fusion for certain patients.

  13. Dynamic modeling of the INAPRO aquaponic system

    NARCIS (Netherlands)

    Karimanzira, Divas; Keesman, Karel J.; Kloas, Werner; Baganz, Daniela; Rauschenbach, Thomas

    2016-01-01

    The use of modeling techniques to analyze aquaponics systems is demonstrated with an example of dynamic modeling for the production of Nile tilapia (Oreochromis niloticus) and tomatoes (Solanum lycopersicon) using the innovative double recirculating aquaponic system ASTAF-PRO. For the management and

  14. Reaction dynamics in polyatomic molecular systems

    Energy Technology Data Exchange (ETDEWEB)

    Miller, W.H. [Lawrence Berkeley Laboratory, CA (United States)

    1993-12-01

    The goal of this program is the development of theoretical methods and models for describing the dynamics of chemical reactions, with specific interest for application to polyatomic molecular systems of special interest and relevance. There is interest in developing the most rigorous possible theoretical approaches and also in more approximate treatments that are more readily applicable to complex systems.

  15. Detection of Abrupt Changes in Dynamic Systems,

    Science.gov (United States)

    1984-01-01

    the detection of abrupt chnages in dynamic systems. These efforts have been motivated by a wide variety of applications includinq the detection of...34Failure Detection in Dynimic Systems," AGARD Lecture Series No. 109 on Fault Tolerance Design and Redundancy Management Technqiues, Athens, Rome, and

  16. Chaotic dynamics in N-body systems

    NARCIS (Netherlands)

    Boekholt, Tjarda Coenraad Nico

    2015-01-01

    Ever since Isaac Newton in 1687 posed the N-body problem, astronomers have been looking for its solutions in order to understand the evolution of dynamical systems, such as our own solar system, star clusters and galaxies. The main difficulty is that small errors grow exponentially, so that numerica

  17. Chaotic dynamics in N-body systems

    NARCIS (Netherlands)

    Boekholt, Tjarda Coenraad Nico

    2015-01-01

    Ever since Isaac Newton in 1687 posed the N-body problem, astronomers have been looking for its solutions in order to understand the evolution of dynamical systems, such as our own solar system, star clusters and galaxies. The main difficulty is that small errors grow exponentially, so that

  18. RESEARCH OF DYNAMIC CHARACTERIATIC FOR TRANSMISSION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The kinetic precision of transmission chain is a key problem in the research of gear cutting machine transmission system.The traditional point of view is to consider the transmission chain as a geometrical meshing system,thus it is deemed that the kinetic precision of the transmission chain only depends on the manufacturing and assembly errors of its transmission parts.But further research reveals that the kinetic precision of transmission system is closely related with the system dynamic effects.Therefore,from the dynamic point of view,it is discerned that not only deems the transmission chain as a geometrical meshing system but also considers it as a dynamic system performing with torsional vibration.On the basis of analyses and processes of measuring data of samples from tests of cutting machine's kinetic precision of transmission chain,the results represent that the influences of dynamic characteristics of the transmission system on its kinetic precision is non-negligible.Experimental methods for discerning the transfer function of torsional vibration of gear transmission system and experimental results have been given.

  19. Transcribing the balanced scorecard into system dynamics

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    2013-01-01

    The purpose of this paper is to show how a System Dynamics Modelling approach can be integrated into the Balanced Scorecard (BSC) for a case company with special focus on the handling of causality in a dynamic perspective. The BSC model includes five perspectives and a number of financial and non......-financial measures. The overall idea of BSC is to make the strategy operational, as proposed by Kaplan and Norton (2007) and to use the strategy for simulation. Our results indicate that a company may gain great insight from simulation studies. The hypothesised model may be used as the first step in quantifying...... the cause-and-effect relationships of an integrated BSC model. Including dynamic aspects of BSCs into the discussion is only in its infancy, so the aim of our work is also to contribute to both scholars’ and practitioners’ general understanding of how such delayed dynamic effects propagate through system...

  20. Topological theory of dynamical systems recent advances

    CERN Document Server

    Aoki, N

    1994-01-01

    This monograph aims to provide an advanced account of some aspects of dynamical systems in the framework of general topology, and is intended for use by interested graduate students and working mathematicians. Although some of the topics discussed are relatively new, others are not: this book is not a collection of research papers, but a textbook to present recent developments of the theory that could be the foundations for future developments. This book contains a new theory developed by the authors to deal with problems occurring in diffentiable dynamics that are within the scope of general topology. To follow it, the book provides an adequate foundation for topological theory of dynamical systems, and contains tools which are sufficiently powerful throughout the book. Graduate students (and some undergraduates) with sufficient knowledge of basic general topology, basic topological dynamics, and basic algebraic topology will find little difficulty in reading this book.

  1. Dynamic Responsive Systems for Catalytic Function.

    Science.gov (United States)

    Vlatković, Matea; Collins, Beatrice S L; Feringa, Ben L

    2016-11-21

    Responsive systems have recently gained much interest in the scientific community in attempts to mimic dynamic functions in biological systems. One of the fascinating potential applications of responsive systems lies in catalysis. Inspired by nature, novel responsive catalytic systems have been built that show analogy with allosteric regulation of enzymes. The design of responsive catalytic systems allows control of catalytic activity and selectivity. In this Review, advances in the field over the last four decades are discussed and a comparison is made amongst the dynamic responsive systems based on the principles underlying their catalytic mechanisms. The catalyst systems are sorted according to the triggers used to achieve control of the catalytic activity and the distinct catalytic reactions illustrated. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Dynamic System Using Conjunctive Operator

    Directory of Open Access Journals (Sweden)

    József Dombi

    2006-01-01

    Full Text Available We present a tool to describe and simulate dynami systems. We use positive andnegative influences. Our starting point is aggregation. We build positive and negativeeffects with proper transformations of the sigmoid function and using the conjunctiveoperator. From the input we calculate the output effect with the help of the aggregationoperator. This algorithm is comparable with the concept of fuzzy cognitive maps.

  3. Dynamical time versus system time inquantum mechanics

    Institute of Scientific and Technical Information of China (English)

    Du(s)an Arsenovi(c); Nikola Buri(c); Dragomir Davidovi(c); Slobodan Prvanovi(c)

    2012-01-01

    Properties of an operator representing the dynamical time in the extended parameterization invariant formulation of quantum mechanics are studied.It is shown that this time operator is given by a positive operator measure analogously to the quantities that are known to represent various measurable time operators.The relation between the dynamical time of the extended formulation and the best known example of the system time operator,i.e.,for the free one-dimensional particle,is obtained.

  4. NONLINEAR DYNAMIC ANALYSIS OF FLEXIBLE MULTIBODY SYSTEM

    Institute of Scientific and Technical Information of China (English)

    A.Y.T.Leung; WuGuorong; ZhongWeifang

    2004-01-01

    The nonlinear dynamic equations of a multibody system composed of flexible beams are derived by using the Lagrange multiplier method. The nonlinear Euler beam theory with inclusion of axial deformation effect is employed and its deformation field is described by exact vibration modes. A numerical procedure for solving the dynamic equations is presented based on the Newmark direct integration method combined with Newton-Raphson iterative method. The results of numerical examples prove the correctness and efficiency of the method proposed.

  5. Solar dynamic power system definition study

    Science.gov (United States)

    Wallin, Wayne E.; Friefeld, Jerry M.

    1988-01-01

    The solar dynamic power system design and analysis study compared Brayton, alkali-metal Rankine, and free-piston Stirling cycles with silicon planar and GaAs concentrator photovoltaic power systems for application to missions beyond the Phase 2 Space Station level of technology for all power systems. Conceptual designs for Brayton and Stirling power systems were developed for 35 kWe and 7 kWe power levels. All power systems were designed for 7-year end-of-life conditions in low Earth orbit. LiF was selected for thermal energy storage for the solar dynamic systems. Results indicate that the Stirling cycle systems have the highest performance (lowest weight and area) followed by the Brayton cycle, with photovoltaic systems considerably lower in performance. For example, based on the performance assumptions used, the planar silicon power system weight was 55 to 75 percent higher than for the Stirling system. A technology program was developed to address areas wherein significant performance improvements could be realized relative to the current state-of-the-art as represented by Space Station. In addition, a preliminary evaluation of hardenability potential found that solar dynamic systems can be hardened beyond the hardness inherent in the conceptual designs of this study.

  6. Network signatures of cellular immortalization in human lymphoblastoid cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Sung-Mi; Jung, So-Young; Nam, Hye-Young; Kim, Hye-Ryun; Lee, Mee-Hee; Kim, Jun-Woo; Han, Bok-Ghee [National Biobank of Korea, Center for Genome Science, Korea National Institute of Health, Osong 363-951 (Korea, Republic of); Jeon, Jae-Pil, E-mail: jaepiljeon@hanmail.net [Division of Brain Diseases, Center for Biomedical Science, Korea National Institute of Health, Osong 363-951 (Korea, Republic of)

    2013-11-15

    Highlights: •We identified network signatures of LCL immortalization from transcriptomic profiles. •More than 41% of DEGs are possibly regulated by miRNAs in LCLs. •MicroRNA target genes in LCLs are involved in apoptosis and immune-related functions. •This approach is useful to find functional miRNA targets in specific cell conditions. -- Abstract: Human lymphoblastoid cell line (LCL) has been used as an in vitro cell model in genetic and pharmacogenomic studies, as well as a good model for studying gene expression regulatory machinery using integrated genomic analyses. In this study, we aimed to identify biological networks of LCL immortalization from transcriptomic profiles of microRNAs and their target genes in LCLs. We first selected differentially expressed genes (DEGs) and microRNAs (DEmiRs) between early passage LCLs (eLCLs) and terminally differentiated late passage LCLs (tLCLs). The in silico and correlation analysis of these DEGs and DEmiRs revealed that 1098 DEG–DEmiR pairs were found to be positively (n = 591 pairs) or negatively (n = 507 pairs) correlated with each other. More than 41% of DEGs are possibly regulated by miRNAs in LCL immortalizations. The target DEGs of DEmiRs were enriched for cellular functions associated with apoptosis, immune response, cell death, JAK–STAT cascade and lymphocyte activation while non-miRNA target DEGs were over-represented for basic cell metabolisms. The target DEGs correlated negatively with miR-548a-3p and miR-219-5p were significantly associated with protein kinase cascade, and the lymphocyte proliferation and apoptosis, respectively. In addition, the miR-106a and miR-424 clusters located in the X chromosome were enriched in DEmiR–mRNA pairs for LCL immortalization. In this study, the integrated transcriptomic analysis of LCLs could identify functional networks of biologically active microRNAs and their target genes involved in LCL immortalization.

  7. Dynamics of Nonlinear Time-Delay Systems

    CERN Document Server

    Lakshmanan, Muthusamy

    2010-01-01

    Synchronization of chaotic systems, a patently nonlinear phenomenon, has emerged as a highly active interdisciplinary research topic at the interface of physics, biology, applied mathematics and engineering sciences. In this connection, time-delay systems described by delay differential equations have developed as particularly suitable tools for modeling specific dynamical systems. Indeed, time-delay is ubiquitous in many physical systems, for example due to finite switching speeds of amplifiers in electronic circuits, finite lengths of vehicles in traffic flows, finite signal propagation times in biological networks and circuits, and quite generally whenever memory effects are relevant. This monograph presents the basics of chaotic time-delay systems and their synchronization with an emphasis on the effects of time-delay feedback which give rise to new collective dynamics. Special attention is devoted to scalar chaotic/hyperchaotic time-delay systems, and some higher order models, occurring in different bran...

  8. Dynamical entropy for systems with stochastic perturbation

    Science.gov (United States)

    Ostruszka; Pakonski; Slomczynski; Zyczkowski

    2000-08-01

    Dynamics of deterministic systems perturbed by random additive noise is characterized quantitatively. Since for such systems the Kolmogorov-Sinai (KS) entropy diverges if the diameter of the partition tends to zero, we analyze the difference between the total entropy of a noisy system and the entropy of the noise itself. We show that this quantity is finite and non-negative and we call it the dynamical entropy of the noisy system. In the weak noise limit this quantity is conjectured to tend to the KS entropy of the deterministic system. In particular, we consider one-dimensional systems with noise described by a finite-dimensional kernel for which the Frobenius-Perron operator can be represented by a finite matrix.

  9. Energy efficiency of a dynamic glazing system

    Energy Technology Data Exchange (ETDEWEB)

    Lollini, R. [Institute for Renewable Energy, EURAC Research, Viale Druso 1, I-39100 Bolzano (Italy); Danza, L.; Meroni, I. [ITC-CNR, Construction Technologies Institute - Italian National Research Council, Via Lombardia, 49 - 20098 San Giuliano Milanese (MI) (Italy)

    2010-04-15

    The reduction of air-conditioning energy consumptions is one of the main indicators to act on when improving the energy efficiency in buildings. In the case of advanced technological buildings, a meaningful contribution to the thermal loads and the energy consumptions reduction could depend on the correct configuration and management of the envelope systems. In recent years, the architectural trend toward highly transparent all-glass buildings presents a unique challenge and opportunity to advance the market for emerging, smart, dynamic window and dimmable daylighting control technologies (). A prototype dynamic glazing system was developed and tested at ITC-CNR; it is aimed at actively responding to the external environmental loads. Both an experimental campaign and analyses by theoretical models were carried out, aimed at evaluating the possible configurations depending on different weather conditions in several possible places. Therefore, the analytical models of the building-plant system were defined by using a dynamic energy simulation software (EnergyPlus). The variables that determine the system performance, also influenced by the boundary conditions, were analysed, such as U- and g-value; they concern both the morphology of the envelope system, such as dimensions, shading and glazing type, gap airflow thickness, in-gap airflow rate, and management, in terms of control algorithm parameters tuning fan and shading systems, as a function of the weather conditions. The configuration able to provide the best performances was finally identified by also assessing such performances, integrating the dynamic system in several building types and under different weather conditions. The dynamic envelope system prototype has become a commercial product with some applications in facade systems, curtain walls and windows. The paper describes the methodological approach to prototype development and the main results obtained, including simulations of possible applications on

  10. Stirling Engine Dynamic System Modeling

    Science.gov (United States)

    Nakis, Christopher G.

    2004-01-01

    The Thermo-Mechanical systems branch at the Glenn Research Center focuses a large amount time on Stirling engines. These engines will be used on missions where solar power is inefficient, especially in deep space. I work with Tim Regan and Ed Lewandowski who are currently developing and validating a mathematical model for the Stirling engines. This model incorporates all aspects of the system including, mechanical, electrical and thermodynamic components. Modeling is done through Simplorer, a program capable of running simulations of the model. Once created and then proven to be accurate, a model is used for developing new ideas for engine design. My largest specific project involves varying key parameters in the model and quantifying the results. This can all be done relatively trouble-free with the help of Simplorer. Once the model is complete, Simplorer will do all the necessary calculations. The more complicated part of this project is determining which parameters to vary. Finding key parameters depends on the potential for a value to be independently altered in the design. For example, a change in one dimension may lead to a proportional change to the rest of the model, and no real progress is made. Also, the ability for a changed value to have a substantial impact on the outputs of the system is important. Results will be condensed into graphs and tables with the purpose of better communication and understanding of the data. With the changing of these parameters, a more optimal design can be created without having to purchase or build any models. Also, hours and hours of results can be simulated in minutes. In the long run, using mathematical models can save time and money. Along with this project, I have many other smaller assignments throughout the summer. My main goal is to assist in the processes of model development, validation and testing.

  11. Handbook of dynamical systems, v.3

    CERN Document Server

    Takens, F; Broer, H W

    2010-01-01

    In this volume, the authors present a collection of surveys on various aspects of the theory of bifurcations of differentiable dynamical systems and related topics. By selecting these subjects, they focus on those developments from which research will be active in the coming years. The surveys are intended to educate the reader on the recent literature on the following subjects: transversality and generic properties like the various forms of the so-called Kupka-Smale theorem, the Closing Lemma and generic local bifurcations of functions (so-called catastrophe theory) and generic local bifurcations in 1-parameter families of dynamical systems, and notions of structural stability and moduli. * Covers recent literature on various topics related to the theory of bifurcations of differentiable dynamical systems* Highlights developments that are the foundation for future research in this field* Provides material in the form of surveys, which are important tools for introducing the bifurcations of differentiable dyn...

  12. Abstraction of Dynamical Systems by Timed Automata

    DEFF Research Database (Denmark)

    Wisniewski, Rafael; Sloth, Christoffer

    2011-01-01

    requirements, which by classical control methods is impossible. We put forward a method for abstracting dynamical systems, where level sets of Lyapunov functions are used to generate the partitioning of the state space. We propose to partition the state space using an entire family of functions. The properties......To enable formal verification of a dynamical system, given by a set of differential equations, it is abstracted by a finite state model. This allows for application of methods for model checking. Consequently, it opens the possibility of carrying out the verification of reachability and timing...... of these functions ensure that the discrete model captures the behaviors of a dynamical system by generating appropriate equivalence classes of the states. These equivalence classes make up the partition of the state space....

  13. On non-stationarity of dynamic systems

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar

    2004-01-01

    . Covariance structure of dynamic systems tends to vary over time. Here some procedures to find stable solutions to linear dynamic systems with low rank are presented. Subsets of variables and samples to be included in a model are considered. The procedures are based on the H-principle of mathematical...... that are based on exact solutions. With in few seconds the algorithms can provide with solutions of models having hundreds or thousands of variables. The procedure is described mathematically and demonstrated for a dynamic industrial case. It is shown how the algorithms can provide solutions involving NIR data...... for process control. The method is simple to apply and the motivation of the procedure is obvious for industrial applications. It can be used, e.g., when modelling on-line systems....

  14. Fully antisymmetrised dynamics for bulk fermion systems

    CERN Document Server

    Vantournhout, Klaas

    2011-01-01

    The neutron star's crust and mantel are typical examples of non-uniform bulk systems with spacial localisations. When modelling such systems at low temperatures, as is the case in the crust, one has to work with antisymmetrised many-body states to get the correct fermion behaviour. Fermionic molecular dynamics, which works with an antisymmetrised product of localised wave packets, should be an appropriate choice. Implementing periodic boundary conditions into the fermionic molecular dynamics formalism would allow the study of the neutron star's crust as a bulk quantum system. Unfortunately, the antisymmetrisation is a non-local entanglement which reaches far out of the periodically repeated unit cell. In this proceeding, we give a brief overview how periodic boundary conditions and fermionic molecular dynamics can be combined without truncating the long-range many-body correlation induced by the antisymmetry of the many-body state.

  15. Abstraction of Dynamical Systems by Timed Automata

    Directory of Open Access Journals (Sweden)

    Rafael Wisniewski

    2011-04-01

    Full Text Available To enable formal verification of a dynamical system, given by a set of differential equations, it is abstracted by a finite state model. This allows for application of methods for model checking. Consequently, it opens the possibility of carrying out the verification of reachability and timing requirements, which by classical control methods is impossible. We put forward a method for abstracting dynamical systems, where level sets of Lyapunov functions are used to generate the partitioning of the state space. We propose to partition the state space using an entire family of functions. The properties of these functions ensure that the discrete model captures the behaviors of a dynamical system by generating appropriate equivalence classes of the states. These equivalence classes make up the partition of the state space.

  16. Recent Developments in System Dynamics Software

    OpenAIRE

    Valyi, I.

    1987-01-01

    This paper is a short review of a conference held in Sevilla, Spain, in October 1987. Organized by the Systems Dynamic Society, it concentrated around concepts in methodology and applications of nonlinear system modelling within the framework introduced by Jay Forrester and his followers. The attitude to this approach is controversial. For example, the respective methodologies do not involve the identification of system parameters and the construction of the models from available data do...

  17. Uncertain dynamical systems: A differential game approach

    Science.gov (United States)

    Gutman, S.

    1976-01-01

    A class of dynamical systems in a conflict situation is formulated and discussed, and the formulation is applied to the study of an important class of systems in the presence of uncertainty. The uncertainty is deterministic and the only assumption is that its value belongs to a known compact set. Asymptotic stability is fully discussed with application to variable structure and model reference control systems.

  18. Power system dynamics stability and control

    CERN Document Server

    Padiyar, K R

    2008-01-01

    Modern power systems tend to be very Complex not only due to increasing Demand for quality power, but also on Account of extensive interconnections and increasing dependence on control for optimum utilization for existing resources. A good Knowledge of system dynamics and control is Essential for secure operation of the system. This book is intended to serve the needs of the Student and practicing engineers. A Large number of illustrative examples are included to provide an insight into the application of the theory.

  19. Nonlinear Dynamics, Chaotic and Complex Systems

    Science.gov (United States)

    Infeld, E.; Zelazny, R.; Galkowski, A.

    2011-04-01

    Part I. Dynamic Systems Bifurcation Theory and Chaos: 1. Chaos in random dynamical systems V. M. Gunldach; 2. Controlling chaos using embedded unstable periodic orbits: the problem of optimal periodic orbits B. R. Hunt and E. Ott; 3. Chaotic tracer dynamics in open hydrodynamical flows G. Karolyi, A. Pentek, T. Tel and Z. Toroczkai; 4. Homoclinic chaos L. P. Shilnikov; Part II. Spatially Extended Systems: 5. Hydrodynamics of relativistic probability flows I. Bialynicki-Birula; 6. Waves in ionic reaction-diffusion-migration systems P. Hasal, V. Nevoral, I. Schreiber, H. Sevcikova, D. Snita, and M. Marek; 7. Anomalous scaling in turbulence: a field theoretical approach V. Lvov and I. Procaccia; 8. Abelian sandpile cellular automata M. Markosova; 9. Transport in an incompletely chaotic magnetic field F. Spineanu; Part III. Dynamical Chaos Quantum Physics and Foundations Of Statistical Mechanics: 10. Non-equilibrium statistical mechanics and ergodic theory L. A. Bunimovich; 11. Pseudochaos in statistical physics B. Chirikov; 12. Foundations of non-equilibrium statistical mechanics J. P. Dougherty; 13. Thermomechanical particle simulations W. G. Hoover, H. A. Posch, C. H. Dellago, O. Kum, C. G. Hoover, A. J. De Groot and B. L. Holian; 14. Quantum dynamics on a Markov background and irreversibility B. Pavlov; 15. Time chaos and the laws of nature I. Prigogine and D. J. Driebe; 16. Evolutionary Q and cognitive systems: dynamic entropies and predictability of evolutionary processes W. Ebeling; 17. Spatiotemporal chaos information processing in neural networks H. Szu; 18. Phase transitions and learning in neural networks C. Van den Broeck; 19. Synthesis of chaos A. Vanecek and S. Celikovsky; 20. Computational complexity of continuous problems H. Wozniakowski; Part IV. Complex Systems As An Interface Between Natural Sciences and Environmental Social and Economic Sciences: 21. Stochastic differential geometry in finance studies V. G. Makhankov; Part V. Conference Banquet

  20. Challenges for ice age dynamics: a dynamical systems perspective

    CERN Document Server

    Crucifix, Michel; Mitsui, Takahito

    2015-01-01

    This chapter is dedicated to the slow dynamics of the climate system, at time scales of one~thousand to one million years. We focus specifically on the phenomenon of ice ages that has characterised the slow evolution of climate over the Quaternary. Ice ages are a form of variability featuring interactions between different large-scale components and processes in the climate system, including ice sheet, deep-ocean and carbon cycle dynamics. This variability is also at least partly controlled by changes in the seasonal and latitudinal incoming solar radiation associated with the combined effects of changes in Earth's orbit shape, precession of equinoxes, and changes in obliquity. A number of possible mechanisms are reviewed in this chapter. We stress that the nature of the interactions between these slow dynamics and faster modes of variability, such as millennium and centennial modes of variability, are still poorly understood. For example, whether the time sequence of ice ages is robustly determined or not by...

  1. The dynamics of surge in compression systems

    Indian Academy of Sciences (India)

    A N Vishwanatha Rao; O N Ramesh

    2007-02-01

    In air-compression systems, instabilities occur during operation close to their peak pressure-rise capability. However, the peak efficiency of a compression system lies close to this region of instability. A surge is a violent mode of instability where there is total breakdown of flow in the system and pressure-rise capability is lost drastically. Generally, all compression systems operate with a margin defined as the ‘surge margin’, and, consequently, system operational efficiency is lower. It is of interest to study compression-system surge to understand its dynamics in order to operate compression systems close to the instability for achieving high efficiency safely without encountering surge. Unsteady pressure data from a compression system, captured during surge oscillations, reveal many aspects of flow physics and are analysed to understand the surge dynamics of the system. A set of controlled experiments was conducted with a simple desktop experimental test set-up and essential aspects of surge dynamics have been characterised.

  2. Quantum Simulation for Open-System Dynamics

    Science.gov (United States)

    Wang, Dong-Sheng; de Oliveira, Marcos Cesar; Berry, Dominic; Sanders, Barry

    2013-03-01

    Simulations are essential for predicting and explaining properties of physical and mathematical systems yet so far have been restricted to classical and closed quantum systems. Although forays have been made into open-system quantum simulation, the strict algorithmic aspect has not been explored yet is necessary to account fully for resource consumption to deliver bounded-error answers to computational questions. An open-system quantum simulator would encompass classical and closed-system simulation and also solve outstanding problems concerning, e.g. dynamical phase transitions in non-equilibrium systems, establishing long-range order via dissipation, verifying the simulatability of open-system dynamics on a quantum Turing machine. We construct an efficient autonomous algorithm for designing an efficient quantum circuit to simulate many-body open-system dynamics described by a local Hamiltonian plus decoherence due to separate baths for each particle. The execution time and number of gates for the quantum simulator both scale polynomially with the system size. DSW funded by USARO. MCO funded by AITF and Brazilian agencies CNPq and FAPESP through Instituto Nacional de Ciencia e Tecnologia-Informacao Quantica (INCT-IQ). DWB funded by ARC Future Fellowship (FT100100761). BCS funded by AITF, CIFAR, NSERC and USARO.

  3. A Dynamical Simulation Facility for Hybrid Systems

    CERN Document Server

    Back, A; Myers, M; Back, Allen; Guckenheimer, John; Myers, Mark

    1993-01-01

    Abstract: This paper establishes a general framework for describing hybrid dynamical systems which is particularly suitable for numerical simulation. In this context, the data structures used to describe the sets and functions which comprise the dynamical system are crucial since they provide the link between a natural mathematical formulation of a problem and the correct application of standard numerical algorithms. We describe a partial implementation of the design methodology and use this simulation tool for a specific control problem in robotics as an illustration of the utility of the approach for practical applications.

  4. Very Large System Dynamics Models - Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    Jacob J. Jacobson; Leonard Malczynski

    2008-10-01

    This paper provides lessons learned from developing several large system dynamics (SD) models. System dynamics modeling practice emphasize the need to keep models small so that they are manageable and understandable. This practice is generally reasonable and prudent; however, there are times that large SD models are necessary. This paper outlines two large SD projects that were done at two Department of Energy National Laboratories, the Idaho National Laboratory and Sandia National Laboratories. This paper summarizes the models and then discusses some of the valuable lessons learned during these two modeling efforts.

  5. Robust control synthesis for uncertain dynamical systems

    Science.gov (United States)

    Byun, Kuk-Whan; Wie, Bong; Sunkel, John

    1989-01-01

    This paper presents robust control synthesis techniques for uncertain dynamical systems subject to structured parameter perturbation. Both QFT (quantitative feedback theory) and H-infinity control synthesis techniques are investigated. Although most H-infinity-related control techniques are not concerned with the structured parameter perturbation, a new way of incorporating the parameter uncertainty in the robust H-infinity control design is presented. A generic model of uncertain dynamical systems is used to illustrate the design methodologies investigated in this paper. It is shown that, for a certain noncolocated structural control problem, use of both techniques results in nonminimum phase compensation.

  6. Reversible part of a quantum dynamical system

    OpenAIRE

    2016-01-01

    In this work a quantum dynamical system $(\\mathfrak M,\\Phi, \\varphi)$ is constituted by a von Neumann algebra $\\mathfrak M$, by a unital Schwartz map $\\Phi:\\mathfrak{M\\rightarrow M}$ and by a $\\Phi$-invariant normal faithful state $\\varphi$ on $\\mathfrak M$. The ergodic properties of a quantum dynamical system, depends on its reversible part $(\\mathfrak{D}_\\infty,\\Phi_\\infty, \\varphi_\\infty)$. It is constituted by a von Neumann sub-algebra $\\mathfrak{D}_\\infty$ of $\\mathfrak M$ by an automorp...

  7. Mechanics and dynamics of reconstituted cytoskeletal systems.

    Science.gov (United States)

    Jensen, Mikkel H; Morris, Eliza J; Weitz, David A

    2015-11-01

    The intracellular cytoskeleton is an active dynamic network of filaments and associated binding proteins that control key cellular properties, such as cell shape and mechanics. Due to the inherent complexity of the cell, reconstituted model systems have been successfully employed to gain an understanding of the fundamental physics governing cytoskeletal processes. Here, we review recent advances and key aspects of these reconstituted systems. We focus on the importance of assembly kinetics and dynamic arrest in determining network mechanics, and highlight novel emergent behavior occurring through interactions between cytoskeletal components in more complex networks incorporating multiple biopolymers and molecular motors.

  8. Operationalizing sustainability in urban coastal systems: a system dynamics analysis.

    Science.gov (United States)

    Mavrommati, Georgia; Bithas, Kostas; Panayiotidis, Panayiotis

    2013-12-15

    We propose a system dynamics approach for Ecologically Sustainable Development (ESD) in urban coastal systems. A systematic analysis based on theoretical considerations, policy analysis and experts' knowledge is followed in order to define the concept of ESD. The principles underlying ESD feed the development of a System Dynamics Model (SDM) that connects the pollutant loads produced by urban systems' socioeconomic activities with the ecological condition of the coastal ecosystem that it is delineated in operational terms through key biological elements defined by the EU Water Framework Directive. The receiving waters of the Athens Metropolitan area, which bears the elements of typical high population density Mediterranean coastal city but which currently has also new dynamics induced by the ongoing financial crisis, are used as an experimental system for testing a system dynamics approach to apply the concept of ESD. Systems' thinking is employed to represent the complex relationships among the components of the system. Interconnections and dependencies that determine the potentials for achieving ESD are revealed. The proposed system dynamics analysis can facilitate decision makers to define paths of development that comply with the principles of ESD.

  9. Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants.

    Science.gov (United States)

    Simon, Matt; Sarkies, Peter; Ikegami, Kohta; Doebley, Anna-Lisa; Goldstein, Leonard D; Mitchell, Jacinth; Sakaguchi, Aisa; Miska, Eric A; Ahmed, Shawn

    2014-05-08

    Defects in the Piwi/piRNA pathway lead to transposon desilencing and immediate sterility in many organisms. We found that the C. elegans Piwi mutant prg-1 became sterile after growth for many generations. This phenotype did not occur for RNAi mutants with strong transposon-silencing defects and was separable from the role of PRG-1 in transgene silencing. Brief periods of starvation extended the transgenerational lifespan of prg-1 mutants by stimulating the DAF-16/FOXO longevity transcription factor. Constitutive activation of DAF-16 via reduced daf-2 insulin/IGF-1 signaling immortalized prg-1 strains via RNAi proteins and histone H3 lysine 4 demethylases. In late-generation prg-1 mutants, desilencing of repetitive segments of the genome occurred, and silencing of repetitive loci was restored in prg-1; daf-2 mutants. This study reveals an unexpected interface between aging and transgenerational maintenance of germ cells, where somatic longevity is coupled to a genome-silencing pathway that promotes germ cell immortality in parallel to the Piwi/piRNA system. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Constraint Embedding Technique for Multibody System Dynamics

    Science.gov (United States)

    Woo, Simon S.; Cheng, Michael K.

    2011-01-01

    Multibody dynamics play a critical role in simulation testbeds for space missions. There has been a considerable interest in the development of efficient computational algorithms for solving the dynamics of multibody systems. Mass matrix factorization and inversion techniques and the O(N) class of forward dynamics algorithms developed using a spatial operator algebra stand out as important breakthrough on this front. Techniques such as these provide the efficient algorithms and methods for the application and implementation of such multibody dynamics models. However, these methods are limited only to tree-topology multibody systems. Closed-chain topology systems require different techniques that are not as efficient or as broad as those for tree-topology systems. The closed-chain forward dynamics approach consists of treating the closed-chain topology as a tree-topology system subject to additional closure constraints. The resulting forward dynamics solution consists of: (a) ignoring the closure constraints and using the O(N) algorithm to solve for the free unconstrained accelerations for the system; (b) using the tree-topology solution to compute a correction force to enforce the closure constraints; and (c) correcting the unconstrained accelerations with correction accelerations resulting from the correction forces. This constraint-embedding technique shows how to use direct embedding to eliminate local closure-loops in the system and effectively convert the system back to a tree-topology system. At this point, standard tree-topology techniques can be brought to bear on the problem. The approach uses a spatial operator algebra approach to formulating the equations of motion. The operators are block-partitioned around the local body subgroups to convert them into aggregate bodies. Mass matrix operator factorization and inversion techniques are applied to the reformulated tree-topology system. Thus in essence, the new technique allows conversion of a system with

  11. Chaotic dynamics of controlled electric power systems

    Science.gov (United States)

    Kozlov, V. N.; Trosko, I. U.

    2016-12-01

    The conditions for appearance of chaotic dynamics of electromagnetic and electromechanical processes in energy systems described by the Park-Gorev bilinear differential equations with account for lags of coordinates and restrictions on control have been formulated. On the basis of classical equations, the parameters of synchronous generators and power lines, at which the chaotic dynamics of energy systems appears, have been found. The qualitative and quantitative characteristics of chaotic processes in energy associations of two types, based on the Hopf theorem, and methods of nonstationary linearization and decompositions are given. The properties of spectral characteristics of chaotic processes have been investigated, and the qualitative similarity of bilinear equations of power systems and Lorentz equations have been found. These results can be used for modernization of the systems of control of energy objects. The qualitative and quantitative characteristics for power energy systems as objects of control and for some laws of control with the feedback have been established.

  12. Complex and Adaptive Dynamical Systems A Primer

    CERN Document Server

    Gros, Claudius

    2011-01-01

    We are living in an ever more complex world, an epoch where human actions can accordingly acquire far-reaching potentialities. Complex and adaptive dynamical systems are ubiquitous in the world surrounding us and require us to adapt to new realities and the way of dealing with them. This primer has been developed with the aim of conveying a wide range of "commons-sense" knowledge in the field of quantitative complex system science at an introductory level, providing an entry point to this both fascinating and vitally important subject. The approach is modular and phenomenology driven. Examples of emerging phenomena of generic importance treated in this book are: -- The small world phenomenon in social and scale-free networks. -- Phase transitions and self-organized criticality in adaptive systems. -- Life at the edge of chaos and coevolutionary avalanches resulting from the unfolding of all living. -- The concept of living dynamical systems and emotional diffusive control within cognitive system theory. Techn...

  13. Complex and adaptive dynamical systems a primer

    CERN Document Server

    Gros, Claudius

    2007-01-01

    We are living in an ever more complex world, an epoch where human actions can accordingly acquire far-reaching potentialities. Complex and adaptive dynamical systems are ubiquitous in the world surrounding us and require us to adapt to new realities and the way of dealing with them. This primer has been developed with the aim of conveying a wide range of "commons-sense" knowledge in the field of quantitative complex system science at an introductory level, providing an entry point to this both fascinating and vitally important subject. The approach is modular and phenomenology driven. Examples of emerging phenomena of generic importance treated in this book are: -- The small world phenomenon in social and scale-free networks. -- Phase transitions and self-organized criticality in adaptive systems. -- Life at the edge of chaos and coevolutionary avalanches resulting from the unfolding of all living. -- The concept of living dynamical systems and emotional diffusive control within cognitive system theory. Techn...

  14. Dynamical entropy for systems with stochastic perturbation

    CERN Document Server

    Ostruszka, A; Slomczynski, W; Zyczkowski, K; Ostruszka, Andrzej; Pakonski, Prot; Slomczynski, Wojciech; Zyczkowski, Karol

    1999-01-01

    Dynamics of deterministic systems perturbed by random additive noise is characterized quantitatively. Since for such systems the KS-entropy diverges we analyse the difference between the total entropy of a noisy system and the entropy of the noise itself. We show that this quantity is non negative and in the weak noise limit is conjectured to tend to the KS-entropy of the deterministic system. In particular, we consider one-dimensional systems with noise described by a finite-dimensional kernel, for which the Frobenius-Perron operator can be represented by a finite matrix.

  15. A dynamic 3D foot reconstruction system.

    Science.gov (United States)

    Thabet, Ali K; Trucco, Emanuele; Salvi, Joaquim; Wang, Weijie; Abboud, Rami J

    2011-01-01

    Foot problems are varied and range from simple disorders through to complex diseases and joint deformities. Wherever possible, the use of insoles, or orthoses, is preferred over surgery. Current insole design techniques are based on static measurements of the foot, despite the fact that orthoses are prevalently used in dynamic conditions while walking or running. This paper presents the design and implementation of a structured-light prototype system providing dense three dimensional (3D) measurements of the foot in motion, and its use to show that foot measurements in dynamic conditions differ significantly from their static counterparts. The input to the system is a video sequence of a foot during a single step; the output is a 3D reconstruction of the plantar surface of the foot for each frame of the input. Engineering and clinical tests were carried out for the validation of the system. The accuracy of the system was found to be 0.34 mm with planar test objects. In tests with real feet, the system proved repeatable, with reconstruction differences between trials one week apart averaging 2.44 mm (static case) and 2.81 mm (dynamic case). Furthermore, a study was performed to compare the effective length of the foot between static and dynamic reconstructions using the 4D system. Results showed an average increase of 9 mm for the dynamic case. This increase is substantial for orthotics design, cannot be captured by a static system, and its subject-specific measurement is crucial for the design of effective foot orthoses.

  16. Safety Injection System Filling Using Dynamic Venting

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Sung Je; Kim, Wong Bae; Huh, Jin; Lee, Joo Hee; Im, In Young; Kim, Eun kee [KEPCO Engineering and Construction Company, Daejeon (Korea, Republic of)

    2015-05-15

    In the APR+, the water-level elevation of the in-containment refueling water storage tank (IRWST) is lower than the highest piping of the SIS. Since the gravity filling of water from IRWST cannot fill all SIS piping, an SIP or an SCP test line is newly provided in order to allow the dynamic venting of the SIS. NEI 09-10 Revision 1a-A has concluded that use of dynamic venting is an effective means to remove gas from local high points and traps in piping when correctly based on the dynamic flow rate, void volume, Floude number, and the system water volume. In this study, feasibility of the dynamic vent is investigated. The work presented in this study evaluates the SIS and the SCS filling using the dynamic venting which is supposed to be applied to the APR+. The main ideas are as follows; 1. Dynamic venting using SIPs for the APR+ is not appropriate on the basis of 12 inches in diameter and with the flow rate, 1,460 gpm. 2. Because the high point of the SIS and the SCS is located at the piping that the two systems are sharing, the accumulated gas at the highest point can be removed by using the SCPs, and the dimension of the new piping will be determined by its length of them and the number of elbows. The calculated results are shown in Table 2. 3. The applicability of the dynamic venting methods using the SCPs that are mentioned above should be evaluated in the aspect of the system operation after the piping arrangements are settled in the APR+. The assessments to determine the pump operation time are also required.

  17. Brand Equity Evolution: a System Dynamics Model

    Directory of Open Access Journals (Sweden)

    Edson Crescitelli

    2009-04-01

    Full Text Available One of the greatest challenges in brand management lies in monitoring brand equity over time. This paper aimsto present a simulation model able to represent this evolution. The model was drawn on brand equity concepts developed by Aaker and Joachimsthaler (2000, using the system dynamics methodology. The use ofcomputational dynamic models aims to create new sources of information able to sensitize academics and managers alike to the dynamic implications of their brand management. As a result, an easily implementable model was generated, capable of executing continuous scenario simulations by surveying casual relations among the variables that explain brand equity. Moreover, the existence of a number of system modeling tools will allow extensive application of the concepts used in this study in practical situations, both in professional and educational settings

  18. Coherent Dynamics of Complex Quantum Systems

    CERN Document Server

    Akulin, Vladimir M

    2006-01-01

    A large number of modern problems in physics, chemistry, and quantum electronics require a consideration of population dynamics in complex multilevel quantum systems. The purpose of this book is to provide a systematic treatment of these questions and to present a number of exactly solvable problems. It considers the different dynamical problems frequently encountered in different areas of physics from the same perspective, based mainly on the fundamental ideas of group theory and on the idea of ensemble average. Also treated are concepts of complete quantum control and correction of decoherence induced errors that are complementary to the idea of ensemble average. "Coherent Dynamics of Complex Quantum Systems" is aimed at senior-level undergraduate students in the areas of Atomic, Molecular, and Laser Physics, Physical Chemistry, Quantum Optics and Quantum Informatics. It should help them put particular problems in these fields into a broader scientific context and thereby take advantage of the well-elabora...

  19. Anomalous Dynamical Responses in a Driven System

    CERN Document Server

    Dutta, Suman

    2016-01-01

    The interplay between structure and dynamics in non-equilibrium steady-state is far from understood. We address this interplay by tracking Brownian Dynamics trajectories of particles in a binary colloid of opposite charges in an external electric field, undergoing cross-over from homogeneous to lane state, a prototype of heterogeneous structure formation in non-equilibrium systems. We show that the length scale of structural correlations controls heterogeneity in diffusion and consequent anomalous dynamic responses, like the exponential tail in probability distributions of particle displacements and stretched exponential structural relaxation. We generalise our observations using equations for steady state density which may aid to understand microscopic basis of heterogeneous diffusion in condensed matter systems.

  20. Prediction of Dynamical Systems by Symbolic Regression

    CERN Document Server

    Quade, Markus; Shafi, Kamran; Niven, Robert K; Noack, Bernd R

    2016-01-01

    We study the modeling and prediction of dynamical systems based on conventional models derived from measurements. Such algorithms are highly desirable in situations where the underlying dynamics are hard to model from physical principles or simplified models need to be found. We focus on symbolic regression methods as a part of machine learning. These algorithms are capable of learning an analytically tractable model from data, a highly valuable property. Symbolic regression methods can be considered as generalized regression methods. We investigate two particular algorithms, the so-called fast function extraction which is a generalized linear regression algorithm, and genetic programming which is a very general method. Both are able to combine functions in a certain way such that a good model for the prediction of the temporal evolution of a dynamical system can be identified. We illustrate the algorithms by finding a prediction for the evolution of a harmonic oscillator based on measurements, by detecting a...

  1. Dynamics of fracture in dissipative systems

    Energy Technology Data Exchange (ETDEWEB)

    Rautiainen, T.T.; Kaski, K. [Helsinki Univ. of Technology, Otaniemi (Finland). Lab. of Computational Engineering; Alava, M.J. [Helsinki Univ. of Technology, Otaniemi (Finland). Lab. of Physics

    1997-12-31

    Dynamics of fracture in two-dimensional systems is studied with a dissipative network model by including the local relaxation of the force field via Maxwellian viscoelasticity. In addition to disorder the fundamentals of crack formation and propagation depend on the strength of dissipation compared to the loading rate. We investigate the dynamics of a single crack and the role of stress reduction at the crack tip when dissipation is increased. As a consequence, the crack starts to propagate slowly and it reaches terminal velocity later. If the relaxation of local forces is strong enough compared with crack velocity, crack arrest takes place. For a disordered system, the presence of strong dissipation in local dynamics is reflected as ductility and as an increase in the damage, accumulated during the fracture process. (orig.) 25 refs.

  2. Integrability of dynamical systems algebra and analysis

    CERN Document Server

    Zhang, Xiang

    2017-01-01

    This is the first book to systematically state the fundamental theory of integrability and its development of ordinary differential equations with emphasis on the Darboux theory of integrability and local integrability together with their applications. It summarizes the classical results of Darboux integrability and its modern development together with their related Darboux polynomials and their applications in the reduction of Liouville and elementary integrabilty and in the center—focus problem, the weakened Hilbert 16th problem on algebraic limit cycles and the global dynamical analysis of some realistic models in fields such as physics, mechanics and biology. Although it can be used as a textbook for graduate students in dynamical systems, it is intended as supplementary reading for graduate students from mathematics, physics, mechanics and engineering in courses related to the qualitative theory, bifurcation theory and the theory of integrability of dynamical systems.

  3. An exploration of dynamical systems and chaos

    CERN Document Server

    Argyris, John H; Haase, Maria; Friedrich, Rudolf

    2015-01-01

    This book is conceived as a comprehensive and detailed text-book on non-linear dynamical systems with particular emphasis on the exploration of chaotic phenomena. The self-contained introductory presentation is addressed both to those who wish to study the physics of chaotic systems and non-linear dynamics intensively as well as those who are curious to learn more about the fascinating world of chaotic phenomena. Basic concepts like Poincaré section, iterated mappings, Hamiltonian chaos and KAM theory, strange attractors, fractal dimensions, Lyapunov exponents, bifurcation theory, self-similarity and renormalisation and transitions to chaos are thoroughly explained. To facilitate comprehension, mathematical concepts and tools are introduced in short sub-sections. The text is supported by numerous computer experiments and a multitude of graphical illustrations and colour plates emphasising the geometrical and topological characteristics of the underlying dynamics. This volume is a completely revised and enlar...

  4. Topic: Catchment system dynamics: Processes and feedbacks

    Science.gov (United States)

    Keesstra, Saskia

    2015-04-01

    In this meeting we can talk about my main expertise: the focus of my research ocus revolves around understanding catchment system dynamics in a holistic way by incorporating both processes on hillslopes as well as in the river channel. Process knowledge enables explanation of the impact of natural and human drivers on the catchment systems and which consequences these drivers have for water and sediment connectivity. Improved understanding of the catchment sediment and water dynamics will empower sustainable land and river management and mitigate soil threats like erosion and off-side water and sediment accumulation with the help of nature's forces. To be able to understand the system dynamics of a catchment, you need to study the catchment system in a holistic way. In many studies only the hillslopes or even plots are studied; or only the channel. However, these systems are connected and should be evaluated together. When studying a catchment system any intervention to the system will create both on- as well as off sites effects, which should especially be taken into account when transferring science into policy regulations or management decisions.

  5. Dynamic system multivariate calibration by system identification methods

    Directory of Open Access Journals (Sweden)

    Rolf Ergon

    1998-04-01

    Full Text Available In the first part of the paper, the optimal estimator for normally nonmeasured primary outputs from a linear and time invariant dynamic system is developed. The estimator is based on an underlying Kalman filter, utilizing all available information in known inputs and measured secondary outputs. Assuming sufficient experimental data, the optimal estimator can be identified by specifying an output error model in a standard prediction error identification method. It is further shown that static estimators found by the ordinary least squares method or multivariate calibration by means of principal component regression (PCR or partial least squares regression (PLSR can be seen as special cases of the optimal dynamic estimator. Finally, it is shown that dynamic system PCR and PLSR solutions can be developed as special cases of the general estimator for dynamic systems.

  6. Controlling Complex Systems and Developing Dynamic Technology

    Science.gov (United States)

    Avizienis, Audrius Victor

    In complex systems, control and understanding become intertwined. Following Ilya Prigogine, we define complex systems as having control parameters which mediate transitions between distinct modes of dynamical behavior. From this perspective, determining the nature of control parameters and demonstrating the associated dynamical phase transitions are practically equivalent and fundamental to engaging with complexity. In the first part of this work, a control parameter is determined for a non-equilibrium electrochemical system by studying a transition in the morphology of structures produced by an electroless deposition reaction. Specifically, changing the size of copper posts used as the substrate for growing metallic silver structures by the reduction of Ag+ from solution under diffusion-limited reaction conditions causes a dynamical phase transition in the crystal growth process. For Cu posts with edge lengths on the order of one micron, local forces promoting anisotropic growth predominate, and the reaction produces interconnected networks of Ag nanowires. As the post size is increased above 10 microns, the local interfacial growth reaction dynamics couple with the macroscopic diffusion field, leading to spatially propagating instabilities in the electrochemical potential which induce periodic branching during crystal growth, producing dendritic deposits. This result is interesting both as an example of control and understanding in a complex system, and as a useful combination of top-down lithography with bottom-up electrochemical self-assembly. The second part of this work focuses on the technological development of devices fabricated using this non-equilibrium electrochemical process, towards a goal of integrating a complex network as a dynamic functional component in a neuromorphic computing device. Self-assembled networks of silver nanowires were reacted with sulfur to produce interfacial "atomic switches": silver-silver sulfide junctions, which exhibit

  7. Dynamics of quasi-stable dissipative systems

    CERN Document Server

    Chueshov, Igor

    2015-01-01

    This book is  devoted to background material and recently developed mathematical methods in the study of infinite-dimensional dissipative systems. The theory of such systems is motivated by the long-term goal to establish rigorous mathematical models for turbulent and chaotic phenomena. The aim here is to offer general methods and abstract results pertaining to fundamental dynamical systems properties related to dissipative long-time behavior. The book systematically presents, develops and uses the quasi-stability method while substantially extending it by including for consideration new classes of models and PDE systems arising in Continuum Mechanics. The book can be used as a textbook in dissipative dynamics at the graduate level.   Igor Chueshov is a Professor of Mathematics at Karazin Kharkov National University in Kharkov, Ukraine.

  8. A dynamically reconfigurable data stream processing system

    Energy Technology Data Exchange (ETDEWEB)

    Nogiec, J.M.; Trombly-Freytag, K.; /Fermilab

    2004-11-01

    This paper describes a component-based framework for data stream processing that allows for configuration, tailoring, and runtime system reconfiguration. The system's architecture is based on a pipes and filters pattern, where data is passed through routes between components. A network of pipes and filters can be dynamically reconfigured in response to a preplanned sequence of processing steps, operator intervention, or a change in one or more data streams. This framework provides several mechanisms supporting dynamic reconfiguration and can be used to build static data stream processing applications such as monitoring or data acquisition systems, as well as self-adjusting systems that can adapt their processing algorithm, presentation layer, or data persistency layer in response to changes in input data streams.

  9. A minimum principle for chaotic dynamical systems

    Science.gov (United States)

    Bracken, Paul; Góra, Paweł; Boyarsky, Abraham

    2002-06-01

    Discrete time dynamical systems generated by the iteration of nonlinear maps, such as the logistic map or the tent map, provide interesting examples of chaotic systems. But what is the physical principle behind the emergence of these maps? In the continuous time settings, differential equations of mechanics arise from the minimization of the energy function (Hamiltonian). However, there is no general physical principle for the discrete time analogue of differential equations, namely, maps. In this note, we present an approach to this problem. Using a natural definition of energy for chaotic systems, we minimize energy subject to the constraint that the observed dynamical system has a known entropy. We consider the case where the natural invariant measure is Lebesgue. Invoking the Euler-Lagrange equation, we derive a nonlinear second order differential equation whose solution is the chaotic map that minimizes energy.

  10. Trust dynamics in a large system implementation

    DEFF Research Database (Denmark)

    Schlichter, Bjarne Rerup; Rose, Jeremy

    2013-01-01

    A large information systems implementation (such as Enterprise Resource Planning systems) relies on the trust of its stakeholders to succeed. Such projects impact diverse groups of stakeholders, each with their legitimate interests and expectations. Levels of stakeholder trust can be expected...... outcomes, but largely ignored the dynamics of trust relations. Giddens, as part of his study of modernity, theorises trust dynamics in relation to abstract social systems, though without focusing on information systems. We use Giddens’ concepts to investigate evolving trust relationships in a longitudinal...... to vary in large-scale implementations (which can take several years), and cannot be taken for granted. Previous studies have largely focused on the taxonomic deconstruction of the trust construct, through point-in-time variance studies. They have identified the relationship between trust and project...

  11. Design tools for complex dynamic security systems.

    Energy Technology Data Exchange (ETDEWEB)

    Byrne, Raymond Harry; Rigdon, James Brian; Rohrer, Brandon Robinson; Laguna, Glenn A.; Robinett, Rush D. III (.; ); Groom, Kenneth Neal; Wilson, David Gerald; Bickerstaff, Robert J.; Harrington, John J.

    2007-01-01

    The development of tools for complex dynamic security systems is not a straight forward engineering task but, rather, a scientific task where discovery of new scientific principles and math is necessary. For years, scientists have observed complex behavior but have had difficulty understanding it. Prominent examples include: insect colony organization, the stock market, molecular interactions, fractals, and emergent behavior. Engineering such systems will be an even greater challenge. This report explores four tools for engineered complex dynamic security systems: Partially Observable Markov Decision Process, Percolation Theory, Graph Theory, and Exergy/Entropy Theory. Additionally, enabling hardware technology for next generation security systems are described: a 100 node wireless sensor network, unmanned ground vehicle and unmanned aerial vehicle.

  12. Diffused Knowledge Immortalizes Itself The LOCKSS Program

    CERN Document Server

    Reich, Victoria A

    2003-01-01

    The LOCKSS model, 'Lots of Copies Keeps Stuff Safe,' creates low-cost, persistent digital 'caches' of authoritative versions of http-delivered content. The LOCKSS software enables institutions to locally collect, store, preserve and archive authorized content, thus safeguarding their community's access to that content. The current version of LOCKSS software is restricted to electronic journals. Accuracy and completeness of LOCKSS caches are assured through a peer-to-peer polling and reputation system (operated through LCAP, LOCKSS' communication protocol), which is both robust and secure. LOCKSS replicas cooperate to detect and repair preservation failures. LOCKSS is designed to run on inexpensive hardware and to require almost no technical administration. The software has been under development since 1999 and is distributed as open source.

  13. The search of a digital immortality?

    Directory of Open Access Journals (Sweden)

    Carla Landuzzi

    2015-12-01

    Full Text Available The text intends to examine how technological innovations allow the construction of web spaces for shared funeral rituals and their partecipation by those same communities that move across the network. It can be assumed a new resacralization process of rituals referring to an individual system of meanings. The web may be capable of reappropriating the experience of pain through new ways that allow flexible access and fruition without spatial or temporal limits. They are interactive rituals that build an elective sociality, as practiced by the inclusion decisions under emotionally meaningful groups. The search for a digital alter ego that will survive the earthly physicality threatens to tarnish the very identity of the dead.

  14. Geometric analysis of nondeterminacy in dynamical systems

    DEFF Research Database (Denmark)

    Wisniewski, Rafal; Raussen, Martin Hubert

    2007-01-01

    This article intends to provide some new insights into concurrency using ideas from the theory of dynamical systems. Inherently discrete concurrency corresponds to a parallel continuous concept: a discrete state space corresponds to a differential manifold, an execution path corresponds to a flow...

  15. Partial dynamical symmetry in a fermion system

    Science.gov (United States)

    Escher; Leviatan

    2000-02-28

    The relevance of the partial dynamical symmetry concept for an interacting fermion system is demonstrated. Hamiltonians with partial SU(3) symmetry are presented in the framework of the symplectic shell model of nuclei and shown to be closely related to the quadrupole-quadrupole interaction. Implications are discussed for the deformed light nucleus 20Ne.

  16. Partial dynamical symmetry in a fermion system

    CERN Document Server

    Escher, J; Escher, Jutta; Leviatan, Amiram

    2000-01-01

    The relevance of the partial dynamical symmetry concept for an interactingfermion system is demonstrated. Hamiltonians with partial SU(3) symmetry arepresented in the framework of the symplectic shell-model of nuclei and shown tobe closely related to the quadrupole-quadrupole interaction. Implications arediscussed for the deformed light nucleus $^{20}$Ne.

  17. On multi-dissipative dynamic systems

    DEFF Research Database (Denmark)

    Thygesen, Uffe Høgsbro

    1999-01-01

    We consider deterministic dynamic systems with state space representations which are dissipative in the sense of Willems (1972) with respect to several supply rates. This property is of interest in robustness analysis and in multi-objective control. We give conditions under which the convex cone...

  18. The Matrix exponential, Dynamic Systems and Control

    DEFF Research Database (Denmark)

    Poulsen, Niels Kjølstad

    2004-01-01

    The matrix exponential can be found in various connections in analysis and control of dynamic systems. In this short note we are going to list a few examples. The matrix exponential usably pops up in connection to the sampling process, whatever it is in a deterministic or a stochastic setting...

  19. Improving homogeneity by dynamic speed limit systems.

    NARCIS (Netherlands)

    Nes, N. van Brandenberg, S. & Twisk, D.A.M.

    2010-01-01

    Homogeneity of driving speeds is an important variable in determining road safety; more homogeneous driving speeds increase road safety. This study investigates the effect of introducing dynamic speed limit systems on homogeneity of driving speeds. A total of 46 subjects twice drove a route along 12

  20. LOCAL ENTROPY FUNCTION OF DYNAMICAL SYSTEM

    Directory of Open Access Journals (Sweden)

    İsmail TOK

    2013-05-01

    Full Text Available In this work, we first,define the entropy function of the topological dynamical system and investigate basic properties of this function without going into details. Let (X,A,T be a probability measure space and consider P = { pl5p2,...,pn} a finite measurable partition of all sub-sets of topological dynamical system (X,T.Then,the quantity H (P = ^ zpt is called the i=1 entropy function of finite measurable partition P.Where f-1 log t if 0 0.If diam(P < s,then the quantity L^ (T = h^ (T - h^ (T,P is called a local entropy function of topological dynamical system (X,T . In conclusion, Let (X,T and (Y,S be two topological dynamical system. If TxS is a transformation defined on the product space (XxY,TxS with (TxS(x , y = (Tx,Sy for all (x,y X x Y.Then L ^^ (TxS = L^d(T + L (S .and, we prove some fundamental properties of this function.

  1. A dynamic systems approach to family assessment

    NARCIS (Netherlands)

    van Geert, PLC; Lichtwarck-Aschoff, A

    2005-01-01

    The dynamic systems approach provides a general framework for studying processes. Properties of that approach are applied to the issue of fan-lily assessment. The description covers methods of assessment of short-term processes (e.g., dyadic interaction) and long-term processes (e.g., changes in int

  2. A Dynamic and Individualized Web System.

    Science.gov (United States)

    Connolly, Christopher G.

    Many universities have striven to provide their students, parents, faculty, staff, and alumni with robust, useful, and informative Web sites. Villanova University (Villanova, Pennsylvania) has spent the last 12 months overhauling its static Web site to a dynamic and individualized Web system. At the outset, the term "portal" was adopted by the…

  3. Major depression as a complex dynamic system

    NARCIS (Netherlands)

    Cramer, A.O.J.; van Borkulo, C.D.; Giltay, E.J.; van der Maas, H.L.J.; Kendler, K.S.; Scheffer, M.; Borsboom, D.

    2016-01-01

    In this paper, we characterize major depression (MD) as a complex dynamic system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulti

  4. Computational dynamics of acoustically driven microsphere systems.

    Science.gov (United States)

    Glosser, Connor; Piermarocchi, Carlo; Li, Jie; Dault, Dan; Shanker, B

    2016-01-01

    We propose a computational framework for the self-consistent dynamics of a microsphere system driven by a pulsed acoustic field in an ideal fluid. Our framework combines a molecular dynamics integrator describing the dynamics of the microsphere system with a time-dependent integral equation solver for the acoustic field that makes use of fields represented as surface expansions in spherical harmonic basis functions. The presented approach allows us to describe the interparticle interaction induced by the field as well as the dynamics of trapping in counter-propagating acoustic pulses. The integral equation formulation leads to equations of motion for the microspheres describing the effect of nondissipative drag forces. We show (1) that the field-induced interactions between the microspheres give rise to effective dipolar interactions, with effective dipoles defined by their velocities and (2) that the dominant effect of an ultrasound pulse through a cloud of microspheres gives rise mainly to a translation of the system, though we also observe both expansion and contraction of the cloud determined by the initial system geometry.

  5. A system dynamics model for communications networks

    Science.gov (United States)

    Awcock, A. J.; King, T. E. G.

    1985-09-01

    An abstract model of a communications network in system dynamics terminology is developed as implementation of this model by a FORTRAN program package developed at RSRE is discussed. The result of this work is a high-level simulation package in which the performance of adaptive routing algorithms and other network controls may be assessed for a network of arbitrary topology.

  6. The Matrix exponential, Dynamic Systems and Control

    DEFF Research Database (Denmark)

    Poulsen, Niels Kjølstad

    2004-01-01

    The matrix exponential can be found in various connections in analysis and control of dynamic systems. In this short note we are going to list a few examples. The matrix exponential usably pops up in connection to the sampling process, whatever it is in a deterministic or a stochastic setting...

  7. Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression.

    Science.gov (United States)

    Gordon, Katrina; Clouaire, Thomas; Bao, Xun X; Kemp, Sadie E; Xenophontos, Maria; de Las Heras, Jose Ignacio; Stancheva, Irina

    2014-04-01

    Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-responsiveness to growth inhibitory signals. Both genetic and epigenetic changes can contribute to cancer development and progression. Given the vast genetic heterogeneity of human cancers and difficulty to monitor cancer-initiating events in vivo, the precise relationship between acquisition of genetic mutations and the temporal progression of epigenetic alterations in transformed cells is largely unclear. Here, we use an in vitro model system to investigate the contribution of cellular immortality and oncogenic transformation of primary human cells to epigenetic reprogramming of DNA methylation and gene expression. Our data demonstrate that extension of replicative life span of the cells is sufficient to induce accumulation of DNA methylation at gene promoters and large-scale changes in gene expression in a time-dependent manner. In contrast, continuous expression of cooperating oncogenes in immortalized cells, although essential for anchorage-independent growth and evasion of apoptosis, does not affect de novo DNA methylation at promoters and induces subtle expression changes. Taken together, these observations imply that cellular immortality promotes epigenetic adaptation to highly proliferative state, whereas transforming oncogenes confer additional properties to transformed human cells.

  8. Dynamic system uncertainty propagation using polynomial chaos

    Directory of Open Access Journals (Sweden)

    Xiong Fenfen

    2014-10-01

    Full Text Available The classic polynomial chaos method (PCM, characterized as an intrusive methodology, has been applied to uncertainty propagation (UP in many dynamic systems. However, the intrusive polynomial chaos method (IPCM requires tedious modification of the governing equations, which might introduce errors and can be impractical. Alternative to IPCM, the non-intrusive polynomial chaos method (NIPCM that avoids such modifications has been developed. In spite of the frequent application to dynamic problems, almost all the existing works about NIPCM for dynamic UP fail to elaborate the implementation process in a straightforward way, which is important to readers who are unfamiliar with the mathematics of the polynomial chaos theory. Meanwhile, very few works have compared NIPCM to IPCM in terms of their merits and applicability. Therefore, the mathematic procedure of dynamic UP via both methods considering parametric and initial condition uncertainties are comparatively discussed and studied in the present paper. Comparison of accuracy and efficiency in statistic moment estimation is made by applying the two methods to several dynamic UP problems. The relative merits of both approaches are discussed and summarized. The detailed description and insights gained with the two methods through this work are expected to be helpful to engineering designers in solving dynamic UP problems.

  9. Dynamic system uncertainty propagation using polynomial chaos

    Institute of Scientific and Technical Information of China (English)

    Xiong Fenfen; Chen Shishi; Xiong Ying

    2014-01-01

    The classic polynomial chaos method (PCM), characterized as an intrusive methodology, has been applied to uncertainty propagation (UP) in many dynamic systems. However, the intrusive polynomial chaos method (IPCM) requires tedious modification of the governing equations, which might introduce errors and can be impractical. Alternative to IPCM, the non-intrusive polynomial chaos method (NIPCM) that avoids such modifications has been developed. In spite of the frequent application to dynamic problems, almost all the existing works about NIPCM for dynamic UP fail to elaborate the implementation process in a straightforward way, which is important to readers who are unfamiliar with the mathematics of the polynomial chaos theory. Meanwhile, very few works have compared NIPCM to IPCM in terms of their merits and applicability. Therefore, the mathematic procedure of dynamic UP via both methods considering parametric and initial condition uncertainties are comparatively discussed and studied in the present paper. Comparison of accuracy and efficiency in statistic moment estimation is made by applying the two methods to several dynamic UP problems. The relative merits of both approaches are discussed and summarized. The detailed description and insights gained with the two methods through this work are expected to be helpful to engineering designers in solving dynamic UP problems.

  10. Dynamic analysis of higher order biological systems.

    Science.gov (United States)

    Sato, K

    1981-01-01

    Humans and animals consist of a variety of bio-systems exhibiting various bio-phenomena over the course of time, from the past to the present and into future, up to just before their death. Each state of a bio-phenomenon at any time is related in stochastic fashion not only to its past history, but those of many other bio- and natural phenomena, enormous in number, in their internal and external environments. Most states of these bio-phenomena sway more or less around respective averages, which suggest their levels of homeostasis, essentially important for maintaining life. In the above past history of sway was hidden an essential characteristic, i.e., dynamic higher-order activity, of the bio-system, whereas the bio- and natural phenomena in the environments act to drive, i.e., stimulate, as an ensemble, the bio-system to exhibit the bio-phenomena as its responses. From this new point of view, mono- and multivariate dynamic stimulation-system (activity)-response relations in stochastic fashion can be seen as an extension leading from of one of the most fundamental static laws of excitability, that is the threshold stimulus-excitability-unit response relation in physiology. The dynamic mono- and multivariate higher-order activities, each of which consisted of some first- and second-order component activities, can be described in the frequency and time-patterns as the power spectral densities or frequency responses and (unit) impulse responses, respectively. Some of these "dynamic activities" were manifested in the brain system of humans and cats, the human "posture holding system," "the pressure regulatory system" in the human pulmonary circulation and the "glucoregulatory system" of dogs, respectively.

  11. Automated design of complex dynamic systems.

    Directory of Open Access Journals (Sweden)

    Michiel Hermans

    Full Text Available Several fields of study are concerned with uniting the concept of computation with that of the design of physical systems. For example, a recent trend in robotics is to design robots in such a way that they require a minimal control effort. Another example is found in the domain of photonics, where recent efforts try to benefit directly from the complex nonlinear dynamics to achieve more efficient signal processing. The underlying goal of these and similar research efforts is to internalize a large part of the necessary computations within the physical system itself by exploiting its inherent non-linear dynamics. This, however, often requires the optimization of large numbers of system parameters, related to both the system's structure as well as its material properties. In addition, many of these parameters are subject to fabrication variability or to variations through time. In this paper we apply a machine learning algorithm to optimize physical dynamic systems. We show that such algorithms, which are normally applied on abstract computational entities, can be extended to the field of differential equations and used to optimize an associated set of parameters which determine their behavior. We show that machine learning training methodologies are highly useful in designing robust systems, and we provide a set of both simple and complex examples using models of physical dynamical systems. Interestingly, the derived optimization method is intimately related to direct collocation a method known in the field of optimal control. Our work suggests that the application domains of both machine learning and optimal control have a largely unexplored overlapping area which envelopes a novel design methodology of smart and highly complex physical systems.

  12. Automated design of complex dynamic systems.

    Science.gov (United States)

    Hermans, Michiel; Schrauwen, Benjamin; Bienstman, Peter; Dambre, Joni

    2014-01-01

    Several fields of study are concerned with uniting the concept of computation with that of the design of physical systems. For example, a recent trend in robotics is to design robots in such a way that they require a minimal control effort. Another example is found in the domain of photonics, where recent efforts try to benefit directly from the complex nonlinear dynamics to achieve more efficient signal processing. The underlying goal of these and similar research efforts is to internalize a large part of the necessary computations within the physical system itself by exploiting its inherent non-linear dynamics. This, however, often requires the optimization of large numbers of system parameters, related to both the system's structure as well as its material properties. In addition, many of these parameters are subject to fabrication variability or to variations through time. In this paper we apply a machine learning algorithm to optimize physical dynamic systems. We show that such algorithms, which are normally applied on abstract computational entities, can be extended to the field of differential equations and used to optimize an associated set of parameters which determine their behavior. We show that machine learning training methodologies are highly useful in designing robust systems, and we provide a set of both simple and complex examples using models of physical dynamical systems. Interestingly, the derived optimization method is intimately related to direct collocation a method known in the field of optimal control. Our work suggests that the application domains of both machine learning and optimal control have a largely unexplored overlapping area which envelopes a novel design methodology of smart and highly complex physical systems.

  13. Keystroke Dynamics Authentication For Collaborative Systems

    OpenAIRE

    Giot, Romain; El-Abed, Mohamad; Rosenberger, Christophe

    2009-01-01

    International audience; We present in this paper a study on the ability and the benefits of using a keystroke dynamics authentication method for collaborative systems. Authentication is a challenging issue in order to guarantee the security of use of collaborative systems during the access control step. Many solutions exist in the state of the art such as the use of one time passwords or smart-cards. We focus in this paper on biometric based solutions that do not necessitate any additional se...

  14. Unified symmetry of Vacco dynamical systems

    Institute of Scientific and Technical Information of China (English)

    Li Yuan-Cheng; Jing Hong-Xing; Xia Li-Li; Wang Jing; Hou Qi-Bao

    2007-01-01

    Based on the total time derivative along the trajectory of the time, we study the unified symmetry of Vacco dynamical systems. The definition and the criterion of the unified symmetry for the system are given. Three kinds of conserved quantities, i.e. the Noether conserved quantity, the generalized Hojman conserved quantity and the Mei conserved quantity, are deduced from the unified symmetry. An example is presented to illustrate the results.

  15. Parameter identifiability of linear dynamical systems

    Science.gov (United States)

    Glover, K.; Willems, J. C.

    1974-01-01

    It is assumed that the system matrices of a stationary linear dynamical system were parametrized by a set of unknown parameters. The question considered here is, when can such a set of unknown parameters be identified from the observed data? Conditions for the local identifiability of a parametrization are derived in three situations: (1) when input/output observations are made, (2) when there exists an unknown feedback matrix in the system and (3) when the system is assumed to be driven by white noise and only output observations are made. Also a sufficient condition for global identifiability is derived.

  16. Nonlinear dynamic macromodeling techniques for audio systems

    Science.gov (United States)

    Ogrodzki, Jan; Bieńkowski, Piotr

    2015-09-01

    This paper develops a modelling method and a models identification technique for the nonlinear dynamic audio systems. Identification is performed by means of a behavioral approach based on a polynomial approximation. This approach makes use of Discrete Fourier Transform and Harmonic Balance Method. A model of an audio system is first created and identified and then it is simulated in real time using an algorithm of low computational complexity. The algorithm consists in real time emulation of the system response rather than in simulation of the system itself. The proposed software is written in Python language using object oriented programming techniques. The code is optimized for a multithreads environment.

  17. Stability precision dynamic testing system on artillery

    Science.gov (United States)

    Wang, Chunyan; Li, Bo

    2014-12-01

    Dynamic feature of Weapon equipments is one of important performance index for evaluating the performance of the whole weapon system. The construction of target range in our country in fire control dynamic testing is relatively backward; therefore, it has greatly influenced the evaluation on the fire control system. In order to solve this problem, it's urgent to develop a new testing instrument so as to adjust to the armament research process and promote weapon system working more efficiently and thereby meeting the needs of modernization in national defense. This paper proposes a new measure which is used to test the stability precision of the fire control system, and it is installed on the moving base. Using the method, we develop a testing system which can test the stability precision of the fire control system and achieve a high precision results after testing. The innovation of the system is we can receive the image not only by CCD, but our eyes. It also adopts digital image-forming and image processing technique for real-time measurement and storing of the target information; it simultaneously adopts the method adjusting the platform and the corresponding fixture mounted on a sample to measure the stable precision and the precision of corner of stabilizator. In this paper, we make a description on the construction of the system and the idea of the designing of the optical system. Finally, we introduce the actual application of the system and testing results.

  18. Synchronization in multicell systems exhibiting dynamic plasticity

    Indian Academy of Sciences (India)

    C Suguna; Somdatta Sinha

    2008-08-01

    Collective behaviour in multicell systems arises from exchange of chemicals/signals between cells and may be different from their intrinsic behaviour. These chemicals are products of regulated networks of biochemical pathways that underlie cellular functions, and can exhibit a variety of dynamics arising from the non-linearity of the reaction processes. We have addressed the emergent synchronization properties of a ring of cells, diffusively coupled by the end product of an intracellular model biochemical pathway exhibiting non-robust birhythmic behaviour. The aim is to examine the role of intercellular interaction in stabilizing the non-robust dynamics in the emergent collective behaviour in the ring of cells. We show that, irrespective of the inherent frequencies of individual cells, depending on the coupling strength, the collective behaviour does synchronize to only one type of oscillations above a threshold number of cells. Using two perturbation analyses, we also show that this emergent synchronized dynamical state is fairly robust under external perturbations. Thus, the inherent plasticity in the oscillatory phenotypes in these model cells may get suppressed to exhibit collective dynamics of a single type in a multicell system, but environmental influences can sometimes expose this underlying plasticity in its collective dynamics.

  19. Taiji Ruler: Legacy of the Sleeping Immortal

    Directory of Open Access Journals (Sweden)

    Kenneth S. Cohen

    2012-07-01

    Full Text Available This article describes the history, development, and principles of the two major Taiji Ruler lineages: one associated with the Song Dynasty (960-1279 CE imperial family, and the other lesser known, Daoist lineage, transmitted by Hu Yaozhen and his successors, including the well known Chen Style Taijiquan teacher, Feng Zhiqiang. The Taiji Ruler is a traditional system of health-enhancing qigong that is attributed to the Song Dynasty Daoist recluse Chen Xiyi and was first taught publicly in the 1950s. The exercises may be practiced while holding a foot-long wooden object, the Ruler, or with a variety of training devices, such as a wooden or stone ball. Mr. Cohen began studying Taji Ruler with various teachers more than 30 years ago, but also bases his research on works in Chinese and English. Both the teachers and literature agree that the ultimate goal of the Ruler is to blend with the original qi of the universe and, in the process, to achieve vitality and longevity.    

  20. Establishment and characterization of a telomerase immortalized porcine luteal cells.

    Science.gov (United States)

    Zhang, Liang; Huang, Yong; Wang, Zhenyu; Luo, Xiaomao; Zhang, Hongling; Du, Qian; Chang, Lingling; Zhao, Xiaomin; Tong, Dewen

    2017-05-01

    Luteal cells play a crucial role in pregnancy through secreting progesterone to maintain pregnancy and support of fetus. However, low cellular yields and inability to passage primary porcine luteal cells (PLCs) in vitro limit the luteal cell study. Therefore, developing an immortalized porcine luteal cell line is necessary for studying luteal cells activity and function in different diseases. In this study, primary PLCs were obtained from gilts at day 30 to day 50 of gestation and immortalized by human telomerase reverse transcriptase (hTERT). The porcine corpus luteal cell line (hTERT-PLCs) expressed hTERT gene steady, maintained high hTERT activity and normal karyotype. The phase contrast microscope and transmission electron microscope observation showed primary PLCs and hTERT-PLCs were polygonal and exhibited abundant mitochondria, smooth endoplasmic reticulum and lipid droplets. 3β hydroxysteroid dehydrogenase (3βHSD) and Oil-Red-O staining showed that hTERT-PLCs at passage 30 and 50 were similar to primary PLCs. The hTERT-PLCs expressed steroidogenesis-related proteins, enzymes and receptors, such as steroidogenic acute regulatory protein, P450 cholesterol side-chain cleavage, 3βHSD, 20αHSD, luteinizing hormone receptor, progesterone receptor, prolactin receptor, estrogen receptorα/β, as well as primary PLCs. Consequently, hTERT-PLCs could secret progesterone and exhibited similar responses to luteinizing hormone and prostaglandin F2α as primary PLCs. In addition, the hTERT-PLCs did not show neoplastic transformation or anchorage independent growth. In summary, we developed an immortalized porcine luteal cell line which maintained its originally morphological, biological and functional characteristics. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. On sequential dynamical systems and simulation

    Energy Technology Data Exchange (ETDEWEB)

    Barrett, C.L.; Mortveit, H.S.; Reidys, C.M.

    1999-06-01

    The generic structure of computer simulations motivates a new class of discrete dynamical systems that captures this structure in a mathematically precise way. This class of systems consists of (1) a loopfree graph {Upsilon} with vertex set {l_brace}1,2,{hor_ellipsis},n{r_brace} where each vertex has a binary state, (2) a vertex labeled set of functions (F{sub i,{Upsilon}}:F{sub 2}{sup n} {r_arrow} F{sub 2}{sup n}){sub i} and (3) a permutation {pi} {element_of} S{sub n}. The function F{sub i,{Upsilon}} updates the state of vertex i as a function of the states of vertex i and its {Upsilon}-neighbors and leaves the states of all other vertices fixed. The permutation {pi} represents the update ordering, i.e., the order in which the functions F{sub i,{Upsilon}} are applied. By composing the functions F{sub i,{Upsilon}} in the order given by {pi} one obtains the dynamical system (equation given in paper) which the authors refer to as a sequential dynamical system, or SDS for short. The authors will present bounds for the number of functionally different systems and for the number of nonisomorphic digraphs {Gamma}[F{sub {Upsilon}},{pi}] that can be obtained by varying the update order and applications of these to specific graphs and graph classes. This will be done using both combinatorial/algebraic techniques and probabilistic techniques. Finally the authors give results on dynamical system properties for some special systems.

  2. The pursuit of immortality: from the ego to the soul.

    Science.gov (United States)

    Miller, Lisa; Miller, Kenneth; Haught, John; Murphy, Nancey

    2011-10-01

    Moderated by Lisa Miller from Newsweek, evolutionary biologist Kenneth Miller (Brown University) and theologians John Haught (Georgetown University) and Nancey Murphy (Fuller Theological Seminary) discuss the questions Are we immortal? Do our souls exist beyond our bodies? and What scientific evidence is there for mystical experience? from a cultural, historical, and scientific perspective. The following is an edited transcript of the discussion that occurred March 23, 2011, 7:00-8:15 PM, at the New York Academy of Sciences in New York City. © 2011 New York Academy of Sciences.

  3. The Immortality of the Soul: History of a Political Argument

    Directory of Open Access Journals (Sweden)

    Miguel Saralegui

    2014-08-01

    Full Text Available The paper examines a fundamental and little studied issue of political theology: the relationship between the defense of the immortality of the soul and the preservation of public order. It carries out a historical survey of authors such as Pietro Pomponazzi and Thomas More, who resort to political reasons in order to defend it, and David Hume, who feels that there are no political grounds to support such a relationship. Finally, the article analyzes the arguments proposed to show that its efficacy is conditioned by the historical situation.

  4. Preparation of dynamic gravity testing system

    Science.gov (United States)

    Bowin, Carl

    Bowin's interest at WHOI is to obtain the most accurate gravity and gravity gradient measurements possible. The Navy's interest is to have the most accurate navigation possible. Neither can have one without the other. Through Zarak Corporation, Bowin has proposed to the Navy Air System Command to develop a dynamic navigational gravity/gravity gradient (NAV/GRAV) system utilizing superconducting squid gravity and tensor gravity gradient sensors for high precision performance. The proposed system development incorporates that inter-dependency, not only to provide the best estimates of both, but also to provide estimates of the quality of the results obtained. Zarak is pursuing funds for the development of superconducting gravity and gravity gradient sensors. Such sensors, when available, will then be utilized in this palletized system for higher accuracy navigation, gravity and gravity gradient determination. It is desired that initial testing utilize Vibrating String Accelerometers (VSA) gravity sensors and readout systems available at WHOI. This way the development and testing of the NAV/GRAV system can proceed using the VSA sensors while the superconducting gravity sensors are being fabricated. Initial dynamic systems tests will be in a van vehicle for convenience and practicality. The system units will be palletized, and therefore they shall be easily transferable, and thus also be usable in aircraft and ships. It is planned that WHOI will have loan of prototype systems for about two months each year for earth research use.

  5. Scalable Molecular Dynamics for Large Biomolecular Systems

    Directory of Open Access Journals (Sweden)

    Robert K. Brunner

    2000-01-01

    Full Text Available We present an optimized parallelization scheme for molecular dynamics simulations of large biomolecular systems, implemented in the production-quality molecular dynamics program NAMD. With an object-based hybrid force and spatial decomposition scheme, and an aggressive measurement-based predictive load balancing framework, we have attained speeds and speedups that are much higher than any reported in literature so far. The paper first summarizes the broad methodology we are pursuing, and the basic parallelization scheme we used. It then describes the optimizations that were instrumental in increasing performance, and presents performance results on benchmark simulations.

  6. Structural dynamics of electronic and photonic systems

    CERN Document Server

    Suhir, Ephraim; Steinberg, David S

    2011-01-01

    The proposed book will offer comprehensive and versatile methodologies and recommendations on how to determine dynamic characteristics of typical micro- and opto-electronic structural elements (printed circuit boards, solder joints, heavy devices, etc.) and how to design a viable and reliable structure that would be able to withstand high-level dynamic loading. Particular attention will be given to portable devices and systems designed for operation in harsh environments (such as automotive, aerospace, military, etc.)  In-depth discussion from a mechanical engineer's viewpoint will be conducte

  7. Coevolutionary immune system dynamics driving pathogen speciation.

    Directory of Open Access Journals (Sweden)

    Kimberly J Schlesinger

    Full Text Available We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen clearance. The dynamics of these chronic infections display emergent structure, including branching patterns corresponding to asexual pathogen speciation, which is fundamentally driven by the coevolutionary interaction. Over time, continued branching creates an increasingly fragile immune system, and leads to the eventual catastrophic loss of immune control.

  8. Dynamical systems with applications using Maple

    CERN Document Server

    Lynch, Stephen

    2001-01-01

    "The text treats a remarkable spectrum of topics and has a little for everyone. It can serve as an introduction to many of the topics of dynamical systems, and will help even the most jaded reader, such as this reviewer, enjoy some of the interactive aspects of studying dynamics using Maple." —UK Nonlinear News (Review of First Edition) "The book will be useful for all kinds of dynamical systems courses…. [It] shows the power of using a computer algebra program to study dynamical systems, and, by giving so many worked examples, provides ample opportunity for experiments. … [It] is well written and a pleasure to read, which is helped by its attention to historical background." —Mathematical Reviews (Review of First Edition) Since the first edition of this book was published in 2001, Maple™ has evolved from Maple V into Maple 13. Accordingly, this new edition has been thoroughly updated and expanded to include more applications, examples, and exercises, all with solutions; two new chapters on neural n...

  9. Geometric phases in discrete dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    Cartwright, Julyan H.E., E-mail: julyan.cartwright@csic.es [Instituto Andaluz de Ciencias de la Tierra, CSIC–Universidad de Granada, E-18100 Armilla, Granada (Spain); Instituto Carlos I de Física Teórica y Computacional, Universidad de Granada, E-18071 Granada (Spain); Piro, Nicolas, E-mail: nicolas.piro@epfl.ch [École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland); Piro, Oreste, E-mail: piro@imedea.uib-csic.es [Departamento de Física, Universitat de les Illes Balears, E-07122 Palma de Mallorca (Spain); Tuval, Idan, E-mail: ituval@imedea.uib-csic.es [Mediterranean Institute for Advanced Studies, CSIC–Universitat de les Illes Balears, E-07190 Mallorca (Spain)

    2016-10-14

    In order to study the behaviour of discrete dynamical systems under adiabatic cyclic variations of their parameters, we consider discrete versions of adiabatically-rotated rotators. Parallelling the studies in continuous systems, we generalize the concept of geometric phase to discrete dynamics and investigate its presence in these rotators. For the rotated sine circle map, we demonstrate an analytical relationship between the geometric phase and the rotation number of the system. For the discrete version of the rotated rotator considered by Berry, the rotated standard map, we further explore this connection as well as the role of the geometric phase at the onset of chaos. Further into the chaotic regime, we show that the geometric phase is also related to the diffusive behaviour of the dynamical variables and the Lyapunov exponent. - Highlights: • We extend the concept of geometric phase to maps. • For the rotated sine circle map, we demonstrate an analytical relationship between the geometric phase and the rotation number. • For the rotated standard map, we explore the role of the geometric phase at the onset of chaos. • We show that the geometric phase is related to the diffusive behaviour of the dynamical variables and the Lyapunov exponent.

  10. Geometry and dynamics of integrable systems

    CERN Document Server

    Matveev, Vladimir

    2016-01-01

    Based on lectures given at an advanced course on integrable systems at the Centre de Recerca Matemàtica in Barcelona, these lecture notes address three major aspects of integrable systems: obstructions to integrability from differential Galois theory; the description of singularities of integrable systems on the basis of their relation to bi-Hamiltonian systems; and the generalization of integrable systems to the non-Hamiltonian settings. All three sections were written by top experts in their respective fields. Native to actual problem-solving challenges in mechanics, the topic of integrable systems is currently at the crossroads of several disciplines in pure and applied mathematics, and also has important interactions with physics. The study of integrable systems also actively employs methods from differential geometry. Moreover, it is extremely important in symplectic geometry and Hamiltonian dynamics, and has strong correlations with mathematical physics, Lie theory and algebraic geometry (including mir...

  11. Dynamical systems on networks a tutorial

    CERN Document Server

    Porter, Mason A

    2016-01-01

    This volume is a tutorial for the study of dynamical systems on networks. It discusses both methodology and models, including spreading models for social and biological contagions. The authors focus especially on “simple” situations that are analytically tractable, because they are insightful and provide useful springboards for the study of more complicated scenarios. This tutorial, which also includes key pointers to the literature, should be helpful for junior and senior undergraduate students, graduate students, and researchers from mathematics, physics, and engineering who seek to study dynamical systems on networks but who may not have prior experience with graph theory or networks. Mason A. Porter is Professor of Nonlinear and Complex Systems at the Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, UK. He is also a member of the CABDyN Complexity Centre and a Tutorial Fellow of Somerville College. James P. Gleeson is Professor of Industrial and Appli...

  12. Solar system dynamics in general relativity

    CERN Document Server

    Battista, Emmanuele; Esposito, Giampiero; Di Fiore, Luciano; Simo, Jules; Grado, Aniello

    2016-01-01

    Recent work in the literature has advocated using the Earth-Moon-planetoid Lagrangian points as observables, in order to test general relativity and effective field theories of gravity in the solar system. However, since the three-body problem of classical celestial mechanics is just an approximation of a much more complicated setting, where all celestial bodies in the solar system are subject to their mutual gravitational interactions, while solar radiation pressure and other sources of nongravitational perturbations also affect the dynamics, it is conceptually desirable to improve the current understanding of solar system dynamics in general relativity, as a first step towards a more accurate theoretical study of orbital motion in the weak-gravity regime. For this purpose, starting from the Einstein equations in the de Donder-Lanczos gauge, this paper arrives first at the Levi-Civita Lagrangian for the geodesic motion of celestial bodies, showing in detail under which conditions the effects of internal stru...

  13. Dynamic graph system for a semantic database

    Science.gov (United States)

    Mizell, David

    2015-01-27

    A method and system in a computer system for dynamically providing a graphical representation of a data store of entries via a matrix interface is disclosed. A dynamic graph system provides a matrix interface that exposes to an application program a graphical representation of data stored in a data store such as a semantic database storing triples. To the application program, the matrix interface represents the graph as a sparse adjacency matrix that is stored in compressed form. Each entry of the data store is considered to represent a link between nodes of the graph. Each entry has a first field and a second field identifying the nodes connected by the link and a third field with a value for the link that connects the identified nodes. The first, second, and third fields represent the rows, column, and elements of the adjacency matrix.

  14. Keystroke Dynamics Authentication For Collaborative Systems

    CERN Document Server

    Giot, Romain; Rosenberger, Christophe; 10.1109/CTS.2009.5067478

    2009-01-01

    We present in this paper a study on the ability and the benefits of using a keystroke dynamics authentication method for collaborative systems. Authentication is a challenging issue in order to guarantee the security of use of collaborative systems during the access control step. Many solutions exist in the state of the art such as the use of one time passwords or smart-cards. We focus in this paper on biometric based solutions that do not necessitate any additional sensor. Keystroke dynamics is an interesting solution as it uses only the keyboard and is invisible for users. Many methods have been published in this field. We make a comparative study of many of them considering the operational constraints of use for collaborative systems.

  15. Keystroke Dynamics-Based Credential Hardening Systems

    Science.gov (United States)

    Bartlow, Nick; Cukic, Bojan

    abstract Keystroke dynamics are becoming a well-known method for strengthening username- and password-based credential sets. The familiarity and ease of use of these traditional authentication schemes combined with the increased trustworthiness associated with biometrics makes them prime candidates for application in many web-based scenarios. Our keystroke dynamics system uses Breiman’s random forests algorithm to classify keystroke input sequences as genuine or imposter. The system is capable of operating at various points on a traditional ROC curve depending on application-specific security needs. As a username/password authentication scheme, our approach decreases the system penetration rate associated with compromised passwords up to 99.15%. Beyond presenting results demonstrating the credential hardening effect of our scheme, we look into the notion that a user’s familiarity to components of a credential set can non-trivially impact error rates.

  16. The impact of anticipation in dynamical systems

    CERN Document Server

    Gerlee, P; Lundh, T; Wennberg, B

    2016-01-01

    The flocking of animals is often modelled as a dynamical system, in which individuals are represented as particles whose interactions are determined by the current state of the system. Many animals, however, including humans, have predictive capabilities, and presumably base their behavioural decisions---at least partially---upon an anticipated state of their environment. We explore a minimal version of this idea in the context of particles that interact according to a pairwise potential. Anticipation enters the picture by calculating the interparticle forces from linear extrapolation of the positions some time $\\tau$ into the future. Our analysis shows that for intermediate values of $\\tau$ the particles rapidly form milling structures, induced by velocity alignment that emerges from the prediction. We also show that for $\\tau > 0$, any dynamical system governed by an even potential becomes dissipative. These results suggest that anticipation could play an important role in collective behaviour, since it ind...

  17. The dynamical crossover in attractive colloidal systems

    Energy Technology Data Exchange (ETDEWEB)

    Mallamace, Francesco [Dipartimento di Fisica e Scienze della Terra, Università di Messina and CNISM, I-98168 Messina (Italy); Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Corsaro, Carmelo [Dipartimento di Fisica e Scienze della Terra, Università di Messina and CNISM, I-98168 Messina (Italy); Stanley, H. Eugene [Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215 (United States); Mallamace, Domenico [Dipartimento di Scienze dell’Ambiente, della Sicurezza, del Territorio, degli Alimenti e della Salute, Università di Messina, I-98166 Messina (Italy); Chen, Sow-Hsin [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2013-12-07

    We study the dynamical arrest in an adhesive hard-sphere colloidal system. We examine a micellar suspension of the Pluronic-L64 surfactant in the temperature (T) and volume fraction (ϕ) phase diagram. According to mode-coupling theory (MCT), this system is characterized by a cusp-like singularity and two glassy phases: an attractive glass (AG) phase and a repulsive glass (RG) phase. The T − ϕ phase diagram of this system as confirmed by a previous series of scattering data also exhibits a Percolation Threshold (PT) line, a reentrant behavior (AG-liquid-RG), and a glass-to-glass transition. The AG phase can be generated out of the liquid phase by using T and ϕ as control parameters. We utilize viscosity and nuclear magnetic resonance (NMR) techniques. NMR data confirm all the characteristic properties of the colloidal system phase diagram and give evidence of the onset of a fractal-like percolating structure at a precise threshold. The MCT scaling laws used to study the shear viscosity as a function of ϕ and T show in both cases a fragile-to-strong liquid glass-forming dynamic crossover (FSC) located near the percolation threshold where the clustering process is fully developed. These results suggest a larger thermodynamic generality for this phenomenon, which is usually studied only as a function of the temperature. We also find that the critical values of the control parameters, coincident with the PT line, define the locus of the FSC. In the region between the FSC and the glass transition lines the system dynamics are dominated by clustering effects. We thus demonstrate that it is possible, using the conceptual framework provided by extended mode-coupling theory, to describe the way a system approaches dynamic arrest, taking into account both cage and hopping effects.

  18. Overcoming Dynamic Disturbances in Imaging Systems

    Science.gov (United States)

    Young, Eric W.; Dente, Gregory C.; Lyon, Richard G.; Chesters, Dennis; Gong, Qian

    2000-01-01

    We develop and discuss a methodology with the potential to yield a significant reduction in complexity, cost, and risk of space-borne optical systems in the presence of dynamic disturbances. More robust systems almost certainly will be a result as well. Many future space-based and ground-based optical systems will employ optical control systems to enhance imaging performance. The goal of the optical control subsystem is to determine the wavefront aberrations and remove them. Ideally reducing an aberrated image of the object under investigation to a sufficiently clear (usually diffraction-limited) image. Control will likely be distributed over several elements. These elements may include telescope primary segments, telescope secondary, telescope tertiary, deformable mirror(s), fine steering mirror(s), etc. The last two elements, in particular, may have to provide dynamic control. These control subsystems may become elaborate indeed. But robust system performance will require evaluation of the image quality over a substantial range and in a dynamic environment. Candidate systems for improvement in the Earth Sciences Enterprise could include next generation Landsat systems or atmospheric sensors for dynamic imaging of individual, severe storms. The technology developed here could have a substantial impact on the development of new systems in the Space Science Enterprise; such as the Next Generation Space Telescope(NGST) and its follow-on the Next NGST. Large Interferometric Systems of non-zero field, such as Planet Finder and Submillimeter Probe of the Evolution of Cosmic Structure, could benefit. These systems most likely will contain large, flexible optormechanical structures subject to dynamic disturbance. Furthermore, large systems for high resolution imaging of planets or the sun from space may also benefit. Tactical and Strategic Defense systems will need to image very small targets as well and could benefit from the technology developed here. We discuss a novel

  19. Dynamic combinatorial self-replicating systems.

    Science.gov (United States)

    Moulin, Emilie; Giuseppone, Nicolas

    2012-01-01

    Thanks to their intrinsic network topologies, dynamic combinatorial libraries (DCLs) represent new tools for investigating fundamental aspects related to self-organization and adaptation processes. Very recently the first examples integrating self-replication features within DCLs have pushed even further the idea of implementing dynamic combinatorial chemistry (DCC) towards minimal systems capable of self-construction and/or evolution. Indeed, feedback loop processes - in particular in the form of autocatalytic reactions - are keystones to build dynamic supersystems which could possibly approach the roots of "Darwinian" evolvability at mesoscale. This topic of current interest also shows significant potentialities beyond its fundamental character, because truly smart and autonomous materials for the future will have to respond to changes of their environment by selecting and by exponentially amplifying their fittest constituents.

  20. A completion construction for continuous dynamical systems

    CERN Document Server

    Calcines, J M Garcia; Rodriguez, M T Rivas

    2012-01-01

    In this work we construct the $\\Co^{\\r}$-completion and $\\Co^{\\l}$-completion of a dynamical system. If $X$ is a flow, we construct canonical maps $X\\to \\Co^{\\r}(X)$ and $X\\to \\Co^{\\l}(X)$ and when these maps are homeomorphism we have the class of $\\Co^{\\r}$-complete and $\\Co^{\\l}$-complete flows, respectively. In this study we find out many relations between the topological properties of the completions and the dynamical properties of a given flow. In the case of a complete flow this gives interesting relations between the topological properties (separability properties, compactness, convergence of nets, etc.) and dynamical properties (periodic points, omega limits, attractors, repulsors, etc.).

  1. uncertain dynamic systems on time scales

    Directory of Open Access Journals (Sweden)

    V. Lakshmikantham

    1995-01-01

    Full Text Available A basic feedback control problem is that of obtaining some desired stability property from a system which contains uncertainties due to unknown inputs into the system. Despite such imperfect knowledge in the selected mathematical model, we often seek to devise controllers that will steer the system in a certain required fashion. Various classes of controllers whose design is based on the method of Lyapunov are known for both discrete [4], [10], [15], and continuous [3–9], [11] models described by difference and differential equations, respectively. Recently, a theory for what is known as dynamic systems on time scales has been built which incorporates both continuous and discrete times, namely, time as an arbitrary closed sets of reals, and allows us to handle both systems simultaneously [1], [2], [12], [13]. This theory permits one to get some insight into and better understanding of the subtle differences between discrete and continuous systems. We shall, in this paper, utilize the framework of the theory of dynamic systems on time scales to investigate the stability properties of conditionally invariant sets which are then applied to discuss controlled systems with uncertain elements. For the notion of conditionally invariant set and its stability properties, see [14]. Our results offer a new approach to the problem in question.

  2. Control theory of digitally networked dynamic systems

    CERN Document Server

    Lunze, Jan

    2013-01-01

    The book gives an introduction to networked control systems and describes new modeling paradigms, analysis methods for event-driven, digitally networked systems, and design methods for distributed estimation and control. Networked model predictive control is developed as a means to tolerate time delays and packet loss brought about by the communication network. In event-based control the traditional periodic sampling is replaced by state-dependent triggering schemes. Novel methods for multi-agent systems ensure complete or clustered synchrony of agents with identical or with individual dynamic

  3. Modal interactions in dynamical and structural systems

    Energy Technology Data Exchange (ETDEWEB)

    Nayfeh, A.H.; Balachandran, B. (Virginia Polytechnic Institute and State Univ., Blacksburg (USA))

    1989-11-01

    The authors review theoretical and experimental studies of the influence of modal interactions on the nonlinear response of harmonically excited structural and dynamical systems. In particular, they discuss the response of pendulums, ships, rings, shells, arches, beam structures, surface waves, and the similarities in the qualitative behavior of these systems. The systems are characterized by quadratic nonlinearities which may lead to two-to-one and combination autoparametric resonances. These resonances give rise to a coupling between the modes involved in the resonance leading to nonlinear periodic, quasi-periodic, and chaotic motions.

  4. Wave disturbance filtering in dynamic positioning systems

    Directory of Open Access Journals (Sweden)

    Tor S. Schei

    1996-04-01

    Full Text Available Three different approaches to wave disturbance filtering in dynamic positioning systems are studied in this paper. It is shown that a conventional design based on notch filters leads to approximately the same achievable performance of the total control system as can be achieved with an observer based design. It is also shown that a proposed passivity based design leads to a conventional filter with PD-controller. However, there is a relation between the parameters in the filter and the PD-controller, which ensures the passivity properties of the control system.

  5. Classical dynamics of particles and systems

    CERN Document Server

    Marion, Jerry B

    1965-01-01

    Classical Dynamics of Particles and Systems presents a modern and reasonably complete account of the classical mechanics of particles, systems of particles, and rigid bodies for physics students at the advanced undergraduate level. The book aims to present a modern treatment of classical mechanical systems in such a way that the transition to the quantum theory of physics can be made with the least possible difficulty; to acquaint the student with new mathematical techniques and provide sufficient practice in solving problems; and to impart to the student some degree of sophistication in handl

  6. Attractivity and bifurcation for nonautonomous dynamical systems

    CERN Document Server

    Rasmussen, Martin

    2007-01-01

    Although, bifurcation theory of equations with autonomous and periodic time dependence is a major object of research in the study of dynamical systems since decades, the notion of a nonautonomous bifurcation is not yet established. In this book, two different approaches are developed which are based on special definitions of local attractivity and repulsivity. It is shown that these notions lead to nonautonomous Morse decompositions, which are useful to describe the global asymptotic behavior of systems on compact phase spaces. Furthermore, methods from the qualitative theory for linear and nonlinear systems are derived, and nonautonomous counterparts of the classical one-dimensional autonomous bifurcation patterns are developed.

  7. International Conference on Dynamical Systems : Theory and Applications

    CERN Document Server

    2016-01-01

    The book is a collection of contributions devoted to analytical, numerical and experimental techniques of dynamical systems, presented at the international conference "Dynamical Systems: Theory and Applications," held in Lódz, Poland on December 7-10, 2015. The studies give deep insight into new perspectives in analysis, simulation, and optimization of dynamical systems, emphasizing directions for future research. Broadly outlined topics covered include: bifurcation and chaos in dynamical systems, asymptotic methods in nonlinear dynamics, dynamics in life sciences and bioengineering, original numerical methods of vibration analysis, control in dynamical systems, stability of dynamical systems, vibrations of lumped and continuous sytems, non-smooth systems, engineering systems and differential equations, mathematical approaches to dynamical systems, and mechatronics.

  8. International Conference on Dynamical Systems : Theory and Applications

    CERN Document Server

    2016-01-01

    The book is the second volume of a collection of contributions devoted to analytical, numerical and experimental techniques of dynamical systems, presented at the international conference "Dynamical Systems: Theory and Applications," held in Lódz, Poland on December 7-10, 2015. The studies give deep insight into new perspectives in analysis, simulation, and optimization of dynamical systems, emphasizing directions for future research. Broadly outlined topics covered include: bifurcation and chaos in dynamical systems, asymptotic methods in nonlinear dynamics, dynamics in life sciences and bioengineering, original numerical methods of vibration analysis, control in dynamical systems, stability of dynamical systems, vibrations of lumped and continuous sytems, non-smooth systems, engineering systems and differential equations, mathematical approaches to dynamical systems, and mechatronics.

  9. Dynamics of vaccination strategies via projected dynamical systems.

    Science.gov (United States)

    Cojocaru, Monica-Gabriela; Bauch, Chris T; Johnston, Matthew D

    2007-07-01

    Previous game theoretical analyses of vaccinating behaviour have underscored the strategic interaction between individuals attempting to maximise their health states, in situations where an individual's health state depends upon the vaccination decisions of others due to the presence of herd immunity. Here, we extend such analyses by applying the theories of variational inequalities (VI) and projected dynamical systems (PDS) to vaccination games. A PDS provides a dynamics that gives the conditions for existence, uniqueness and stability properties of Nash equilibria. In this paper, it is used to analyse the dynamics of vaccinating behaviour in a population consisting of distinct social groups, where each group has different perceptions of vaccine and disease risks. In particular, we study populations with two groups, where the size of one group is strictly larger than the size of the other group (a majority/minority population). We find that a population with a vaccine-inclined majority group and a vaccine-averse minority group exhibits higher average vaccine coverage than the corresponding homogeneous population, when the vaccine is perceived as being risky relative to the disease. Our model also reproduces a feature of real populations: In certain parameter regimes, it is possible to have a majority group adopting high vaccination rates and simultaneously a vaccine-averse minority group adopting low vaccination rates. Moreover, we find that minority groups will tend to exhibit more extreme changes in vaccinating behaviour for a given change in risk perception, in comparison to majority groups. These results emphasise the important role played by social heterogeneity in vaccination behaviour, while also highlighting the valuable role that can be played by PDS and VI in mathematical epidemiology.

  10. Network Physiology: How Organ Systems Dynamically Interact.

    Science.gov (United States)

    Bartsch, Ronny P; Liu, Kang K L; Bashan, Amir; Ivanov, Plamen Ch

    2015-01-01

    We systematically study how diverse physiologic systems in the human organism dynamically interact and collectively behave to produce distinct physiologic states and functions. This is a fundamental question in the new interdisciplinary field of Network Physiology, and has not been previously explored. Introducing the novel concept of Time Delay Stability (TDS), we develop a computational approach to identify and quantify networks of physiologic interactions from long-term continuous, multi-channel physiological recordings. We also develop a physiologically-motivated visualization framework to map networks of dynamical organ interactions to graphical objects encoded with information about the coupling strength of network links quantified using the TDS measure. Applying a system-wide integrative approach, we identify distinct patterns in the network structure of organ interactions, as well as the frequency bands through which these interactions are mediated. We establish first maps representing physiologic organ network interactions and discover basic rules underlying the complex hierarchical reorganization in physiologic networks with transitions across physiologic states. Our findings demonstrate a direct association between network topology and physiologic function, and provide new insights into understanding how health and distinct physiologic states emerge from networked interactions among nonlinear multi-component complex systems. The presented here investigations are initial steps in building a first atlas of dynamic interactions among organ systems.

  11. Dynamical Systems on Spectral Metric Spaces

    CERN Document Server

    Bellissard, Jean V; Reihani, Kamran

    2010-01-01

    Let (A,H,D) be a spectral triple, namely: A is a C*-algebra, H is a Hilbert space on which A acts and D is a selfadjoint operator with compact resolvent such that the set of elements of A having a bounded commutator with D is dense. A spectral metric space, the noncommutative analog of a complete metric space, is a spectral triple (A,H,D) with additional properties which guaranty that the Connes metric induces the weak*-topology on the state space of A. A *-automorphism respecting the metric defined a dynamical system. This article gives various answers to the question: is there a canonical spectral triple based upon the crossed product algebra AxZ, characterizing the metric properties of the dynamical system ? If $\\alpha$ is the noncommutative analog of an isometry the answer is yes. Otherwise, the metric bundle construction of Connes and Moscovici is used to replace (A,$\\alpha$) by an equivalent dynamical system acting isometrically. The difficulties relating to the non compactness of this new system are di...

  12. The Dynamic Balancer electrical safety systems

    Energy Technology Data Exchange (ETDEWEB)

    Konkel, H.

    1997-12-01

    The Pantex Plant Dynamic Balancer is used to identify physical imbalance in some weapon systems. This study was conducted at the request of the US Department of Energy/Albuquerque Operations Office (USDOE/AL) Dynamic Balancer Project Team to identify the electrical conditions required for motor over-speed to occur and to discuss the functions of the various electrical protective features associated with the Dynamic Balancer (DB). As is shown through the development of a fault tree, numerous electrical and human failures are required for over-speed conditions to occur. As directed by the Project Team, no effort was made to develop detailed fault trees for all electrical systems, to quantify basic events in the fault tree, or to develop accident scenarios leading to or resulting from over-speed. The Pantex Building 12-60, Bay 2, facility electrical circuits and grounding are described, and potential hazards are discussed. DB motor over-speed is a safety concern, and therefore, the controls that limit this condition are described and discussed in detail. Other safety-significant electrical circuits are discussed as well. These safety systems also are described in the facility Basis for Interim Operation. A potential for a motor over-speed that is not sensed by the standard safety protective systems does exist. This fault pathway is discussed, and recommendations to mitigate its effect are made.

  13. Network Physiology: How Organ Systems Dynamically Interact.

    Directory of Open Access Journals (Sweden)

    Ronny P Bartsch

    Full Text Available We systematically study how diverse physiologic systems in the human organism dynamically interact and collectively behave to produce distinct physiologic states and functions. This is a fundamental question in the new interdisciplinary field of Network Physiology, and has not been previously explored. Introducing the novel concept of Time Delay Stability (TDS, we develop a computational approach to identify and quantify networks of physiologic interactions from long-term continuous, multi-channel physiological recordings. We also develop a physiologically-motivated visualization framework to map networks of dynamical organ interactions to graphical objects encoded with information about the coupling strength of network links quantified using the TDS measure. Applying a system-wide integrative approach, we identify distinct patterns in the network structure of organ interactions, as well as the frequency bands through which these interactions are mediated. We establish first maps representing physiologic organ network interactions and discover basic rules underlying the complex hierarchical reorganization in physiologic networks with transitions across physiologic states. Our findings demonstrate a direct association between network topology and physiologic function, and provide new insights into understanding how health and distinct physiologic states emerge from networked interactions among nonlinear multi-component complex systems. The presented here investigations are initial steps in building a first atlas of dynamic interactions among organ systems.

  14. Towards Maturity in 1 Peter: Freedom, Holiness, Immortality

    Directory of Open Access Journals (Sweden)

    Paul B. Decock

    2016-04-01

    Full Text Available Growth towards maturity is dependent on the presence of freedom, holiness and immortality. These are presented as divine qualities that are utterly lacking in human beings. However, while human beings are ignorant and weak, sinful and mortal the addressees of 1 Peter1 are reminded that they have also been begotten anew by the imperishable seed of God’s Word, the Good News of Jesus Christ in order to share immortal life. This article looks first at human beings who as God’s creatures are ‘flesh’, but are also enabled to acknowledge their ‘fleshly’ state, to appreciate (‘desire’ and ‘taste’ (2:2–3 the Gospel and to submit to God. The second part considers the saving role of Christ as the powerful yet rejected ‘stone’ placed and offered by God as the model and means to transcend the ‘flesh’ in the flesh (4:1–2. A final part focuses on the new birth and the growth process in which the fleshly desires and ways of living give way to a manner of life, which is a witness to God’s saving power.

  15. Introduction to turbulent dynamical systems in complex systems

    CERN Document Server

    Majda, Andrew J

    2016-01-01

    This volume is a research expository article on the applied mathematics of turbulent dynamical systems through the paradigm of modern applied mathematics. It involves the blending of rigorous mathematical theory, qualitative and quantitative modeling, and novel numerical procedures driven by the goal of understanding physical phenomena which are of central importance to the field. The contents cover general framework, concrete examples, and instructive qualitative models. Accessible open problems are mentioned throughout. Topics covered include: · Geophysical flows with rotation, topography, deterministic and random forcing · New statistical energy principles for general turbulent dynamical systems, with applications · Linear statistical response theory combined with information theory to cope with model errors · Reduced low order models · Recent mathematical strategies for online data assimilation of turbulent dynamical systems as well as rigorous results for finite ensemble Kalman filters The volume wi...

  16. Immortalization protocols used in cell culture models of human breast morphogenesis

    DEFF Research Database (Denmark)

    Gudjonsson, T; Villadsen, R; Rønnov-Jessen, L

    2004-01-01

    of the tissue of origin. In recent years, we have sought to establish immortalized primary breast cells, which retain crucial characteristics of their original in situ tissue pattern. This review discusses various approaches to immortalization of breast-derived epithelial and stromal cells and the application...

  17. Dying To Teach: The Educator's Search for Immortality. Advances in Contemporary Educational Thought Series, Volume 18.

    Science.gov (United States)

    Blacker, David J.

    This book offers both an intellectual history and a sustained argument for the inescapability of education's immortality agenda. It seeks a Hegelian synthesis of common ideas about living in one's students by giving them something of oneself, developing the image of immortality as an a-temporal, mythic, meaning-making, relational enterprise.…

  18. Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation

    NARCIS (Netherlands)

    Schippers, IJ; Moshage, H; Roelofsen, H; Muller, M; Heymans, HSA; Ruiters, M; Kuipers, F

    Primary human hepatocytes were immortalized by stable transfection with a recombinant plasmid containing the early region of simian virus (SV) 40. The cells were cultured in serum-free, hormonally defined medium during the immortalization procedure. Foci of dividing cells were seen after 3 months.

  19. Quantum speed limits in open system dynamics.

    Science.gov (United States)

    del Campo, A; Egusquiza, I L; Plenio, M B; Huelga, S F

    2013-02-01

    Bounds to the speed of evolution of a quantum system are of fundamental interest in quantum metrology, quantum chemical dynamics, and quantum computation. We derive a time-energy uncertainty relation for open quantum systems undergoing a general, completely positive, and trace preserving evolution which provides a bound to the quantum speed limit. When the evolution is of the Lindblad form, the bound is analogous to the Mandelstam-Tamm relation which applies in the unitary case, with the role of the Hamiltonian being played by the adjoint of the generator of the dynamical semigroup. The utility of the new bound is exemplified in different scenarios, ranging from the estimation of the passage time to the determination of precision limits for quantum metrology in the presence of dephasing noise.

  20. Classification framework for partially observed dynamical systems

    Science.gov (United States)

    Shen, Yuan; Tino, Peter; Tsaneva-Atanasova, Krasimira

    2017-04-01

    We present a general framework for classifying partially observed dynamical systems based on the idea of learning in the model space. In contrast to the existing approaches using point estimates of model parameters to represent individual data items, we employ posterior distributions over model parameters, thus taking into account in a principled manner the uncertainty due to both the generative (observational and/or dynamic noise) and observation (sampling in time) processes. We evaluate the framework on two test beds: a biological pathway model and a stochastic double-well system. Crucially, we show that the classification performance is not impaired when the model structure used for inferring posterior distributions is much more simple than the observation-generating model structure, provided the reduced-complexity inferential model structure captures the essential characteristics needed for the given classification task.

  1. Dynamical systems with applications using MATLAB

    CERN Document Server

    Lynch, Stephen

    2014-01-01

    This textbook, now in its second edition, provides a broad introduction to both continuous and discrete dynamical systems, the theory of which is motivated by examples from a wide range of disciplines. It emphasizes applications and simulation utilizing MATLAB®, Simulink®, the Image Processing Toolbox™, and the Symbolic Math Toolbox™, including MuPAD. Features new to the second edition include, sections on series solutions of ordinary differential equations, perturbation methods, normal forms, Gröbner bases, and chaos synchronization; chapters on image processing and binary oscillator computing; hundreds of new illustrations, examples, and exercises with solutions; and over eighty up-to-date MATLAB® program files and Simulink model files available online. These files were voted MATLAB® Central Pick of the Week in July 2013.  The hands-on approach of Dynamical Systems with Applications using MATLAB®, Second Edition, has minimal prerequisites, only requiring familiarity with ordinary differential equ...

  2. A dynamical system for interacting flapping swimmers

    Science.gov (United States)

    Oza, Anand; Ramananarivo, Sophie; Ristroph, Leif; Shelley, Michael

    2015-11-01

    We present the results of a theoretical investigation into the dynamics of interacting flapping swimmers. Our study is motivated by the recent experiments of Becker et al., who studied a one-dimensional array of self-propelled flapping wings that swim within each other's wakes in a water tank. They discovered that the system adopts certain ``schooling modes'' characterized by specific spatial phase relationships between swimmers. To rationalize these phenomena, we develop a discrete dynamical system in which the swimmers are modeled as heaving airfoils that shed point vortices during each flapping cycle. We then apply our model to recent experiments in the Applied Math Lab, in which two tandem flapping airfoils are free to choose both their speed and relative positions. We expect that our model may be used to understand how schooling behavior is influenced by hydrodynamics in more general contexts. Thanks to the NSF for its support.

  3. Fission dynamics with systems of intermediate fissility

    Indian Academy of Sciences (India)

    E Vardaci; A Di Nitto; P N Nadtochy; A Brondi; G La Rana; R Moro; M Cinausero; G Prete; N Gelli; E M Kozulin; G N Knyazheva; I M Itkis

    2015-08-01

    A 4 light charged particle spectrometer, called 8 LP, is in operation at the Laboratori Nazionali di Legnaro, Italy, for studying reaction mechanisms in low-energy heavy-ion reactions. Besides about 300 telescopes to detect light charged particles, the spectrometer is also equipped with an anular PPAC system to detect evaporation residues and a two-arm time-of-flight spectrometer to detect fission fragments. The spectrometer has been used in several fission dynamics studies using as a probe light charged particles in the fission and evaporation residues (ER) channels. This paper proposes a journey within some open questions about the fission dynamics and a review of the main results concerning nuclear dissipation and fission time-scale obtained from several of these studies. In particular, the advantages of using systems of intermediate fissility will be discussed.

  4. A Type System for Dynamic Web Documents

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Sandholm, Anders

    2000-01-01

    Many interactive Web services use the CGI interface for communication with clients. They will dynamically create HTML documents that are presented to the client who then resumes the interaction by submitting data through incorporated form fields. This protocol is difficult to statically type......-check if the dynamic documents are created by arbitrary script code using printf-like statements. Previous proposals have suggested using static document templates which trades flexibility for safety. We propose a notion of typed, higher-order templates that simultaneously achieve flexibility and safety. Our type...... system is based on a flow analysis of which we prove soundness. We present an efficient runtime implementation that respects the semantics of only well-typed programs. This work is fully implemented as part of the system for defining interactive Web services....

  5. High Performance Interactive System Dynamics Visualization

    Energy Technology Data Exchange (ETDEWEB)

    Bush, Brian W [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Brunhart-Lupo, Nicholas J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Gruchalla, Kenny M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Duckworth, Jonathan C [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-14

    This brochure describes a system dynamics simulation (SD) framework that supports an end-to-end analysis workflow that is optimized for deployment on ESIF facilities(Peregrine and the Insight Center). It includes (I) parallel and distributed simulation of SD models, (ii) real-time 3D visualization of running simulations, and (iii) comprehensive database-oriented persistence of simulation metadata, inputs, and outputs.

  6. Introduction to differential equations with dynamical systems

    CERN Document Server

    Campbell, Stephen L

    2011-01-01

    Many textbooks on differential equations are written to be interesting to the teacher rather than the student. Introduction to Differential Equations with Dynamical Systems is directed toward students. This concise and up-to-date textbook addresses the challenges that undergraduate mathematics, engineering, and science students experience during a first course on differential equations. And, while covering all the standard parts of the subject, the book emphasizes linear constant coefficient equations and applications, including the topics essential to engineering students. Stephen Cam

  7. Temporal logic runtime verification of dynamic systems

    CSIR Research Space (South Africa)

    Seotsanyana, M

    2010-07-01

    Full Text Available linear temporal logic as well as extended regular expressions. Java with assertion (Jass) [8] is a general monitoring methodology implemented for sequential, concurrent and reactive systems written in java. The tool Jass is a pre- compiler... that translates annotations into a pure java code in which a compliance with specification is tested dynamically at runtime. Assertions extends the Design by Contract [11], that allows specification of assertions in the form of pre- and post-conditions, class...

  8. High Performance Interactive System Dynamics Visualization

    Energy Technology Data Exchange (ETDEWEB)

    Bush, Brian W [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Brunhart-Lupo, Nicholas J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Gruchalla, Kenny M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Duckworth, Jonathan C [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-14

    This presentation describes a system dynamics simulation (SD) framework that supports an end-to-end analysis workflow that is optimized for deployment on ESIF facilities(Peregrine and the Insight Center). It includes (I) parallel and distributed simulation of SD models, (ii) real-time 3D visualization of running simulations, and (iii) comprehensive database-oriented persistence of simulation metadata, inputs, and outputs.

  9. Second International Colloquium on Dynamical Systems

    CERN Document Server

    Seade, José; Verjovski, Alberto

    1988-01-01

    The objective of the meeting was to have together leading specialists in the field of Holomorphic Dynamical Systems in order to present their current reseach in the field. The scope was to cover iteration theory of holomorphic mappings (i.e. rational maps), holomorphic differential equations and foliations. Many of the conferences and articles included in the volume contain open problems of current interest. The volume contains only research articles.

  10. Quantum Dynamics of Nonlinear Cavity Systems

    OpenAIRE

    Nation, Paul D.

    2010-01-01

    We investigate the quantum dynamics of three different configurations of nonlinear cavity systems. To begin, we carry out a quantum analysis of a dc superconducting quantum interference device (SQUID) mechanical displacement detector comprised of a SQUID with a mechanically compliant loop segment. The SQUID is approximated by a nonlinear current-dependent inductor, inducing a flux tunable nonlinear Duffing term in the cavity equation of motion. Expressions are derived for the detector signal ...

  11. Aspects of effective dynamics for nonequilibrium systems

    OpenAIRE

    Thomas, Simi

    2013-01-01

    In this work we present a few general and some specific aspects of effective dynamics of macroscopic observables, obtained through the study of some models. The purpose of statistical physics is to build connections between microscopic variables (which are enormous in number and usually fast in ``speed'') and the macroscopic variables (usually fewer and slower compared to the microscopic variables). Much can be inferred about the microscopic state of a system from the nature of a well defined...

  12. NMR Dynamic Studies in Living Systems

    Institute of Scientific and Technical Information of China (English)

    闫永彬; 范明杰; 罗雪春; 张日清

    2002-01-01

    Nuclear magnetic resonance (NMR) can noninvasively monitor the intracellular concentrations and kinetic properties of numerous inorganic and organic compounds. These characteristics have made NMR a useful tool for dynamic studies of living systems. Applications of NMR to living systems have successfully extended to many areas, including studies of metabolic regulation, ion transport, and intracellular reaction rates in vivo. The major purpose of this review is to summarize the results that can be obtained by modern NMR techniques in living systems. With the advances of new techniques, NMR measurements of various nuclides have been performed for specific physiological purposes. Although some technical problems still remain and there are still discrepancies between NMR and traditional biochemical results, the abundant and unique information obtained from NMR spectra suggests that NMR will be more extensively applied in future studies of living systems. The fast development of these new techniques is providing many new NMR applications in living systems, as well as in structural biology.

  13. Complex and adaptive dynamical systems a primer

    CERN Document Server

    Gros, Claudius

    2013-01-01

    Complex system theory is rapidly developing and gaining importance, providing tools and concepts central to our modern understanding of emergent phenomena. This primer offers an introduction to this area together with detailed coverage of the mathematics involved. All calculations are presented step by step and are straightforward to follow. This new third edition comes with new material, figures and exercises. Network theory, dynamical systems and information theory, the core of modern complex system sciences, are developed in the first three chapters, covering basic concepts and phenomena like small-world networks, bifurcation theory and information entropy. Further chapters use a modular approach to address the most important concepts in complex system sciences, with the emergence and self-organization playing a central role. Prominent examples are self-organized criticality in adaptive systems, life at the edge of chaos, hypercycles and coevolutionary avalanches, synchronization phenomena, absorbing phase...

  14. Dynamic Channel Allocation in Sectored Cellular Systems

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It is known that dynamic channel assignment(DCA) strategy outperforms the fixed channel assignment(FCA) strategy in omni-directional antenna cellular systems. One of the most important methods used in DCA was channel borrowing. But with the emergence of cell sectorization and spatial division multiple access(SDMA) which are used to increase the capacity of cellular systems, the channel assignment faces a series of new problems. In this paper, a dynamic channel allocation scheme based on sectored cellular systems is proposed. By introducing intra-cell channel borrowing (borrowing channels from neighboring sectors) and inter-cell channel borrowing (borrowing channels from neighboring cells) methods, previous DCA strategies, including compact pattern based channel borrowing(CPCB) and greedy based dynamic channel assignment(GDCA) schemes proposed by the author, are improved significantly. The computer simulation shows that either intra-cell borrowing scheme or inter-cell borrowing scheme is efficient enough to uniform and non-uniform traffic service distributions.

  15. Prediction of dynamical systems by symbolic regression

    Science.gov (United States)

    Quade, Markus; Abel, Markus; Shafi, Kamran; Niven, Robert K.; Noack, Bernd R.

    2016-07-01

    We study the modeling and prediction of dynamical systems based on conventional models derived from measurements. Such algorithms are highly desirable in situations where the underlying dynamics are hard to model from physical principles or simplified models need to be found. We focus on symbolic regression methods as a part of machine learning. These algorithms are capable of learning an analytically tractable model from data, a highly valuable property. Symbolic regression methods can be considered as generalized regression methods. We investigate two particular algorithms, the so-called fast function extraction which is a generalized linear regression algorithm, and genetic programming which is a very general method. Both are able to combine functions in a certain way such that a good model for the prediction of the temporal evolution of a dynamical system can be identified. We illustrate the algorithms by finding a prediction for the evolution of a harmonic oscillator based on measurements, by detecting an arriving front in an excitable system, and as a real-world application, the prediction of solar power production based on energy production observations at a given site together with the weather forecast.

  16. Immortalization capacity of HPV types is inversely related to chromosomal instability

    DEFF Research Database (Denmark)

    Schütze, Denise M; Krijgsman, Oscar; Snijders, Peter J F

    2016-01-01

    High-risk human papillomavirus (hrHPV) types induce immortalization of primary human epithelial cells. Previously we demonstrated that immortalization of human foreskin keratinocytes (HFKs) is HPV type dependent, as reflected by the presence or absence of a crisis period before reaching immortality....... This study determined how the immortalization capacity of ten hrHPV types relates to DNA damage induction and overall genomic instability in HFKs.Twenty five cell cultures obtained by transduction of ten hrHPV types (i.e. HPV16/18/31/33/35/45/51/59/66/70 E6E7) in two or three HFK donors each were studied.......All hrHPV-transduced HFKs showed an increased number of double strand DNA breaks compared to controls, without exhibiting significant differences between types. However, immortal descendants of HPV-transduced HFKs that underwent a prior crisis period (HPV45/51/59/66/70-transduced HFKs) showed...

  17. Effects of hTERT immortalization on osteogenic and adipogenic differentiation of dental pulp stem cells

    Directory of Open Access Journals (Sweden)

    Ikbale El-Ayachi

    2016-03-01

    Full Text Available These data relate to the differentiation of human dental pulp stem cells (DPSC and DPSC immortalized by constitutively expressing human telomerase reverse transcriptase (hTERT through both osteogenic and adipogenic lineages (i.e. to make bone producing and fat producing cells from these dental pulp stem cells. The data augment another study to characterize immortalized DPSC for the study of neurogenetic “Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders” [1]. Two copies of one typical control cell line (technical replicates were used in this study. The data represent the differentiation of primary DPSC into osteoblast cells approximately 60% more effectively than hTERT immortalized DPSC. Conversely, both primary and immortalized DPSC are poorly differentiated into adipocytes. The mRNA expression levels for both early and late adipogenic and osteogenic gene markers are shown.

  18. Metric Entropy of Nonautonomous Dynamical Systems

    Directory of Open Access Journals (Sweden)

    Kawan Christoph

    2014-01-01

    Full Text Available We introduce the notion of metric entropy for a nonautonomous dynamical system given by a sequence (Xn; μn of probability spaces and a sequence of measurable maps fn : Xn → Xn+1 with fnμn = μn+1. This notion generalizes the classical concept of metric entropy established by Kolmogorov and Sinai, and is related via a variational inequality to the topological entropy of nonautonomous systems as defined by Kolyada, Misiurewicz, and Snoha. Moreover, it shares several properties with the classical notion of metric entropy. In particular, invariance with respect to appropriately defined isomorphisms, a power rule, and a Rokhlin-type inequality are proved

  19. Testing relativity with solar system dynamics

    Science.gov (United States)

    Hellings, R. W.

    1984-01-01

    A major breakthrough is described in the accuracy of Solar System dynamical tests of relativistic gravity. The breakthrough was achieved by factoring in ranging data from Viking Landers 1 and 2 from the surface of Mars. Other key data sources included optical transit circle observations, lunar laser ranging, planetary radar, and spacecraft (Mariner 9 to Mars and Mariner 10 to Mercury). The Solar System model which is used to fit the data and the process by which such fits are performed are explained and results are discussed. The results are fully consistent with the predictions of General Relativity.

  20. Non-Markovian Dynamics of Quantum Systems

    Science.gov (United States)

    Chruściński, Dariusz; Kossakowski, Andrzej

    2011-01-01

    We analyze a local approach to the non-Markovian evolution of open quantum systems. It turns out that any dynamical map representing evolution of such a system may be described either by non-local master equation with memory kernel or equivalently by equation which is local in time. The price one pays for the local approach is that the corresponding generator might be highly singular and it keeps the memory about the starting point 't0'. Remarkably, singularities of generator may lead to interesting physical phenomena like revival of coherence or sudden death and revival of entanglement.

  1. Non-Markovian dynamics for bipartite systems

    OpenAIRE

    2008-01-01

    We analyze the appearance of non-Markovian effects in the dynamics of a bipartite system coupled to a reservoir, which can be described within a class of non-Markovian equations given by a generalized Lindblad structure. A novel master equation, which we term quantum Bloch-Boltzmann equation, is derived, describing both motional and internal states of a test particle in a quantum framework. When due to the preparation of the system or to decoherence effects one of the two degrees of freedom i...

  2. Testing relativity with solar system dynamics

    Science.gov (United States)

    Hellings, R. W.

    1984-01-01

    A major breakthrough is described in the accuracy of Solar System dynamical tests of relativistic gravity. The breakthrough was achieved by factoring in ranging data from Viking Landers 1 and 2 from the surface of Mars. Other key data sources included optical transit circle observations, lunar laser ranging, planetary radar, and spacecraft (Mariner 9 to Mars and Mariner 10 to Mercury). The Solar System model which is used to fit the data and the process by which such fits are performed are explained and results are discussed. The results are fully consistent with the predictions of General Relativity.

  3. Vertebrate gravity sensors as dynamic systems

    Science.gov (United States)

    Ross, M. D.

    1985-01-01

    This paper considers verterbrate gravity receptors as dynamic sensors. That is, it is hypothesized that gravity is a constant force to which an acceleration-sensing system would readily adapt. Premises are considered in light of the presence of kinocilia on hair cells of vertebrate gravity sensors; differences in loading of the sensors among species; and of possible reduction in loading by inclusion of much organic material in otoconia. Moreover, organic-inorganic interfaces may confer a piezoelectric property upon otoconia, which increase the sensitivity of the sensory system to small accelerations. Comparisons with man-made accelerometers are briefly taken up.

  4. Cosmic infinity: A dynamical system approach

    CERN Document Server

    Bouhmadi-López, Mariam; Morais, João; Silva, César M

    2016-01-01

    Dynamical system techniques are extremely useful to study cosmology. It turns out that in most of the cases, we deal with finite isolated fixed points corresponding to a given cosmological epoch. However, it is equally important to analyse the asymptotic behaviour of the universe. On this paper, we show how this can be carried out for 3-forms model. In fact, we show that there are fixed points at infinity mainly by introducing appropriate compactifications and defining a new time variable that washes away any potential divergence of the system. The richness of 3-form models allows us as well to identify normally hyperbolic non-isolated fixed points.

  5. Dynamical properties of unconventional magnetic systems

    Energy Technology Data Exchange (ETDEWEB)

    Helgesen, G. [ed.

    1997-05-01

    The Advanced Study Institute addressed the current experimental and theoretical knowledge of the dynamical properties of unconventional magnetic systems including low-dimensional and mesoscopic magnetism, unconventional ground state, quantum magnets and soft matter. The main approach in this Advanced Study Institute was to obtain basic understanding of co-operative phenomena, fluctuations and excitations in the wide range unconventional magnetic systems now being fabricated or envisioned. The report contains abstracts for lectures, invited seminars and posters, together with a list of the 95 participants from 24 countries with e-mail addresses

  6. Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy.

    Science.gov (United States)

    Duesberg, Peter; McCormack, Amanda

    2013-03-01

    Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Here we advance a karyotypic theory of immortality based on the theory that carcinogenesis is a form of speciation. Accordingly, cancers are generated from normal cells by random karyotypic rearrangements and selection for cancer-specific reproductive autonomy. Since such rearrangements unbalance long-established mitosis genes, cancer karyotypes vary spontaneously but are stabilized perpetually by clonal selections for autonomy. To test this theory we have analyzed neoplastic clones, presumably immortalized by transfection with overexpressed telomerase or with SV40 tumor virus, for the predicted clonal yet flexible karyotypes. The following results were obtained: (1) All immortal tumorigenic lines from cells transfected with overexpressed telomerase had clonal and flexible karyotypes; (2) Searching for the origin of such karyotypes, we found spontaneously increasing, random aneuploidy in human fibroblasts early after transfection with overexpressed telomerase; (3) Late after transfection, new immortal tumorigenic clones with new clonal and flexible karyotypes were found; (4) Testing immortality of one clone during 848 unselected generations showed the chromosome number was stable, but the copy numbers of 36% of chromosomes drifted ± 1; (5) Independent immortal tumorigenic clones with individual, flexible karyotypes arose after individual latencies; (6) Immortal tumorigenic clones with new flexible karyotypes also arose late from cells of a telomerase-deficient mouse rendered aneuploid by SV40 virus. Because immortality and tumorigenicity: (1) correlated exactly with individual clonal but flexible karyotypes; (2) originated simultaneously with such karyotypes; and (3) arose in the absence of telomerase, we conclude that clonal and flexible karyotypes generate the immortality of cancers.

  7. Robustness of dynamic systems with parameter uncertainties

    CERN Document Server

    Balemi, S; Truöl, W

    1992-01-01

    Robust Control is one of the fastest growing and promising areas of research today. In many practical systems there exist uncertainties which have to be considered in the analysis and design of control systems. In the last decade methods were developed for dealing with dynamic systems with unstructured uncertainties such as HOO_ and £I-optimal control. For systems with parameter uncertainties, the seminal paper of V. L. Kharitonov has triggered a large amount of very promising research. An international workshop dealing with all aspects of robust control was successfully organized by S. P. Bhattacharyya and L. H. Keel in San Antonio, Texas, USA in March 1991. We organized the second international workshop in this area in Ascona, Switzer­ land in April 1992. However, this second workshop was restricted to robust control of dynamic systems with parameter uncertainties with the objective to concentrate on some aspects of robust control. This book contains a collection of papers presented at the International W...

  8. Literature Review on Dynamic Cellular Manufacturing System

    Science.gov (United States)

    Nouri Houshyar, A.; Leman, Z.; Pakzad Moghadam, H.; Ariffin, M. K. A. M.; Ismail, N.; Iranmanesh, H.

    2014-06-01

    In previous decades, manufacturers faced a lot of challenges because of globalization and high competition in markets. These problems arise from shortening product life cycle, rapid variation in demand of products, and also rapid changes in manufcaturing technologies. Nowadays most manufacturing companies expend considerable attention for improving flexibility and responsiveness in order to overcome these kinds of problems and also meet customer's needs. By considering the trend toward the shorter product life cycle, the manufacturing environment is towards manufacturing a wide variety of parts in small batches [1]. One of the major techniques which are applied for improving manufacturing competitiveness is Cellular Manufacturing System (CMS). CMS is type of manufacturing system which tries to combine flexibility of job shop and also productivity of flow shop. In addition, Dynamic cellular manufacturing system which considers different time periods for the manufacturing system becomes an important topic and attracts a lot of attention to itself. Therefore, this paper made attempt to have a brief review on this issue and focused on all published paper on this subject. Although, this topic gains a lot of attention to itself during these years, none of previous researchers focused on reviewing the literature of that which can be helpful and useful for other researchers who intend to do the research on this topic. Therefore, this paper is the first study which has focused and reviewed the literature of dynamic cellular manufacturing system.

  9. Introduction to Dynamical Systems and Geometric Mechanics

    Science.gov (United States)

    Maruskin, Jared M.

    2012-01-01

    Introduction to Dynamical Systems and Geometric Mechanics provides a comprehensive tour of two fields that are intimately entwined: dynamical systems is the study of the behavior of physical systems that may be described by a set of nonlinear first-order ordinary differential equations in Euclidean space, whereas geometric mechanics explores similar systems that instead evolve on differentiable manifolds. In the study of geometric mechanics, however, additional geometric structures are often present, since such systems arise from the laws of nature that govern the motions of particles, bodies, and even galaxies. In the first part of the text, we discuss linearization and stability of trajectories and fixed points, invariant manifold theory, periodic orbits, Poincaré maps, Floquet theory, the Poincaré-Bendixson theorem, bifurcations, and chaos. The second part of the text begins with a self-contained chapter on differential geometry that introduces notions of manifolds, mappings, vector fields, the Jacobi-Lie bracket, and differential forms. The final chapters cover Lagrangian and Hamiltonian mechanics from a modern geometric perspective, mechanics on Lie groups, and nonholonomic mechanics via both moving frames and fiber bundle decompositions. The text can be reasonably digested in a single-semester introductory graduate-level course. Each chapter concludes with an application that can serve as a springboard project for further investigation or in-class discussion.

  10. Recovery of important physiological functions in 3D culture of immortal hepatocytes

    DEFF Research Database (Denmark)

    Wrzesinski, Krzysztof; Fey, S. J.

    2011-01-01

    hepatocytes using the classical approaches (in “2D”) and using a system which leads to the generation of spheroids of cells held in suspension (“3D”). Both approaches gave rise to cultures where the large majority of cells were viable, produced similar amounts of ATP, incorporated similar amounts......It is widely expected that cells grown in 3D environments (in suspension, on scaffolds etc.) will be superior to growing cells in classical 2D culture flasks. These expectations include the belief that cells grown in 3D culture will possess physiological characteristics that resemble more closely...... to grow human liver cells in ‘3 dimensional’ cultures so that they behave very similar to the liver in our bodies. By growing the immortal hepatocytes in specially designed bioreactors they form small pieces of ‘pseudotissue’ which exhibit several of the functions seen in the adult liver. We have grown...

  11. Two Core Systems of Dynamic Logic

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-jun; LI Ke-sheng; HAO Yi-jiang

    2012-01-01

    Dynamic Logic (DL) is a formal system for reasoning on the input/output behaviors of programs. Hoare Logic (HL) is the precursor of all dynamic logics known today. Two core systems of DL are Propositional Dynamic Logic (PDL) and Quantificational Dynamic Logic (QDL). PDL is an extension of propositional logic with programs and is the appropriate place to begin investigating DL. QDL can be viewed as the first-order version of PDL. Predicate Dynamic Logic (DPL) is a subsystem of QDL and can be regarded as the most basic of a hierarchy of formulas-as-programs languages. These systems constitute the main topic of this essay. The authors’ elaboration here is very brief and sketchy and with the aim of providing the readers with only the most essence of the topic on the basis of other researchers’ works. The last part is the important one in which the authors summarize the approaches of extending Dynamic Logic. The conclusions are as follows: variants of DL are obtained by reinterpreting some constructs as something else, and/or by adding rules or operators, and/or by restricting or extending or revising some constructs, and/or combining a kind of logic with another one, and/or using a comprehensive way which insights from other disciplines according to its application in various domains. In all these cases, the authors give examples to illustrate the conclusion. It is generally proposed that sometimes the introduction of a new operator or rule or construct, or the introduction of reinterpretation or restriction or extension or revision of some constructs will increase expressive power and sometimes not; sometimes it has effect on the complexity of deciding satisfiability and sometimes not. Finally, the authors sum up major aspects which we should consider during investigating a specific variant of DL. The researchers should focus on the well-formed expressions and on the validity of expressions about it with respect to standard, non-standard and syntactically

  12. Complex and adaptive dynamical systems a primer

    CERN Document Server

    Gros, Claudius

    2015-01-01

    This primer offers readers an introduction to the central concepts that form our modern understanding of complex and emergent behavior, together with detailed coverage of accompanying mathematical methods. All calculations are presented step by step and are easy to follow. This new fourth edition has been fully reorganized and includes new chapters, figures and exercises. The core aspects of modern complex system sciences are presented in the first chapters, covering network theory, dynamical systems, bifurcation and catastrophe theory, chaos and adaptive processes, together with the principle of self-organization in reaction-diffusion systems and social animals. Modern information theoretical principles are treated in further chapters, together with the concept of self-organized criticality, gene regulation networks, hypercycles and coevolutionary avalanches, synchronization phenomena, absorbing phase transitions and the cognitive system approach to the brain. Technical course prerequisites are the standard ...

  13. Probabilistic Model for Dynamic Signature Verification System

    Directory of Open Access Journals (Sweden)

    Chai Tong Yuen

    2011-11-01

    Full Text Available This study has proposed the algorithm for signature verification system using dynamic parameters of the signature: pen pressure, velocity and position. The system is proposed to read, analyze and verify the signatures from the SUSig online database. Firstly, the testing and reference samples will have to be normalized, re-sampled and smoothed through pre-processing stage. In verification stage, the difference between reference and testing signatures will be calculated based on the proposed thresholded standard deviation method. A probabilistic acceptance model has been designed to enhance the performance of the verification system. The proposed algorithm has reported False Rejection Rate (FRR of 14.8% and False Acceptance Rate (FAR of 2.64%. Meanwhile, the classification rate of the system is around 97%.

  14. Dynamical Systems Theory: Application to Pedagogy

    Science.gov (United States)

    Abraham, Jane L.

    Theories of learning affect how cognition is viewed, and this subsequently leads to the style of pedagogical practice that is used in education. Traditionally, educators have relied on a variety of theories on which to base pedagogy. Behavioral learning theories influenced the teaching/learning process for over 50 years. In the 1960s, the information processing approach brought the mind back into the learning process. The current emphasis on constructivism integrates the views of Piaget, Vygotsky, and cognitive psychology. Additionally, recent scientific advances have allowed researchers to shift attention to biological processes in cognition. The problem is that these theories do not provide an integrated approach to understanding principles responsible for differences among students in cognitive development and learning ability. Dynamical systems theory offers a unifying theoretical framework to explain the wider context in which learning takes place and the processes involved in individual learning. This paper describes how principles of Dynamic Systems Theory can be applied to cognitive processes of students, the classroom community, motivation to learn, and the teaching/learning dynamic giving educational psychologists a framework for research and pedagogy.

  15. Persistent topological features of dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    Maletić, Slobodan, E-mail: slobodan@hitsz.edu.cn [Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen (China); Institute of Nuclear Sciences Vinča, University of Belgrade, Belgrade (Serbia); Zhao, Yi, E-mail: zhao.yi@hitsz.edu.cn [Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen (China); Rajković, Milan, E-mail: milanr@vinca.rs [Institute of Nuclear Sciences Vinča, University of Belgrade, Belgrade (Serbia)

    2016-05-15

    Inspired by an early work of Muldoon et al., Physica D 65, 1–16 (1993), we present a general method for constructing simplicial complex from observed time series of dynamical systems based on the delay coordinate reconstruction procedure. The obtained simplicial complex preserves all pertinent topological features of the reconstructed phase space, and it may be analyzed from topological, combinatorial, and algebraic aspects. In focus of this study is the computation of homology of the invariant set of some well known dynamical systems that display chaotic behavior. Persistent homology of simplicial complex and its relationship with the embedding dimensions are examined by studying the lifetime of topological features and topological noise. The consistency of topological properties for different dynamic regimes and embedding dimensions is examined. The obtained results shed new light on the topological properties of the reconstructed phase space and open up new possibilities for application of advanced topological methods. The method presented here may be used as a generic method for constructing simplicial complex from a scalar time series that has a number of advantages compared to the mapping of the same time series to a complex network.

  16. On potential kernels associated with random dynamical systems

    Directory of Open Access Journals (Sweden)

    Mohamed Hmissi

    2015-01-01

    In particular, we provide a constructive method for global Lyapunov functions for gradient-like random dynamical systems. This result generalizes an analogous theorem known for deterministic dynamical systems.

  17. A dynamic human health risk assessment system.

    Science.gov (United States)

    Prasad, Umesh; Singh, Gurmit; Pant, A B

    2012-05-01

    An online human health risk assessment system (OHHRAS) has been designed and developed in the form of a prototype database-driven system and made available for the population of India through a website - www.healthriskindia.in. OHHRAS provide the three utilities, that is, health survey, health status, and bio-calculators. The first utility health survey is functional on the basis of database being developed dynamically and gives the desired output to the user on the basis of input criteria entered into the system; the second utility health status is providing the output on the basis of dynamic questionnaire and ticked (selected) answers and generates the health status reports based on multiple matches set as per advise of medical experts and the third utility bio-calculators are very useful for the scientists/researchers as online statistical analysis tool that gives more accuracy and save the time of user. The whole system and database-driven website has been designed and developed by using the software (mainly are PHP, My-SQL, Deamweaver, C++ etc.) and made available publically through a database-driven website (www.healthriskindia.in), which are very useful for researchers, academia, students, and general masses of all sectors.

  18. Modeling the Dynamic Digestive System Microbiome

    Directory of Open Access Journals (Sweden)

    Anne M. Estes

    2015-08-01

    Full Text Available “Modeling the Dynamic Digestive System Microbiome” is a hands-on activity designed to demonstrate the dynamics of microbiome ecology using dried pasta and beans to model disturbance events in the human digestive system microbiome. This exercise demonstrates how microbiome diversity is influenced by: 1 niche availability and habitat space and 2 a major disturbance event, such as antibiotic use. Students use a pictorial key to examine prepared models of digestive system microbiomes to determine what the person with the microbiome “ate.” Students then model the effect of taking antibiotics by removing certain “antibiotic sensitive” pasta. Finally, they add in “environmental microbes” or “native microbes” to recolonize the digestive system, determine how resilient their model microbome community is to disturbance, and discuss the implications. Throughout the exercise, students discuss differences in the habitat space available and microbiome community diversity. This exercise can be modified to discuss changes in the microbiome due to diet shifts and the emergence of antibiotic resistance in more depth.

  19. Quantitative Adaptation Analytics for Assessing Dynamic Systems of Systems.

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, John H.; Miner, Nadine E.; Wilson, Michael L.; Le, Hai D.; Kao, Gio K; Melander, Darryl J.; Longsine, Dennis Earl [Sandia National Laboratories, Unknown, Unknown; Vander Meer, Robert Charles,

    2015-01-01

    Our society is increasingly reliant on systems and interoperating collections of systems, known as systems of systems (SoS). These SoS are often subject to changing missions (e.g., nation- building, arms-control treaties), threats (e.g., asymmetric warfare, terrorism), natural environments (e.g., climate, weather, natural disasters) and budgets. How well can SoS adapt to these types of dynamic conditions? This report details the results of a three year Laboratory Directed Research and Development (LDRD) project aimed at developing metrics and methodologies for quantifying the adaptability of systems and SoS. Work products include: derivation of a set of adaptability metrics, a method for combining the metrics into a system of systems adaptability index (SoSAI) used to compare adaptability of SoS designs, development of a prototype dynamic SoS (proto-dSoS) simulation environment which provides the ability to investigate the validity of the adaptability metric set, and two test cases that evaluate the usefulness of a subset of the adaptability metrics and SoSAI for distinguishing good from poor adaptability in a SoS. Intellectual property results include three patents pending: A Method For Quantifying Relative System Adaptability, Method for Evaluating System Performance, and A Method for Determining Systems Re-Tasking.

  20. System and mathematical modeling of quadrotor dynamics

    Science.gov (United States)

    Goodman, Jacob M.; Kim, Jinho; Gadsden, S. Andrew; Wilkerson, Stephen A.

    2015-05-01

    Unmanned aerial systems (UAS) are becoming increasingly visible in our daily lives; and range in operation from search and rescue, monitoring hazardous environments, and to the delivery of goods. One of the most popular UAS are based on a quad-rotor design. These are typically small devices that rely on four propellers for lift and movement. Quad-rotors are inherently unstable, and rely on advanced control methodologies to keep them operating safely and behaving in a predictable and desirable manner. The control of these devices can be enhanced and improved by making use of an accurate dynamic model. In this paper, we examine a simple quadrotor model, and note some of the additional dynamic considerations that were left out. We then compare simulation results of the simple model with that of another comprehensive model.

  1. Curating Transient Population in Urban Dynamics System

    CERN Document Server

    Thakur, Gautam S; Stewart, Robert N; Urban, Marie L; Bhaduri, Budhendra L

    2016-01-01

    For past several decades, research efforts in population modelling has proven its efficacy in understanding the basic information about residential and commercial areas, as well as for the purposes of planning, development and improvement of the community as an eco-system. More or less, such efforts assume static nature of population distribution, in turn limited by the current ability to capture the dynamics of population change at a finer resolution of space and time. Fast forward today, more and more people are becoming mobile, traveling across borders impacting the nuts and bolts of our urban fabric. Unfortunately, our current efforts are being surpassed by the need to capture such transient population. It is becoming imperative to identify and define them, as well as measure their dynamics and interconnectedness. In this work, we intend to research urban population mobility patterns, gauge their transient nature, and extend our knowledge of their visited locations. We plan to achieve this by designing an...

  2. Dynamics of quantum trajectories in chaotic systems

    CERN Document Server

    Wisniacki, D A; Benito, R M

    2003-01-01

    Quantum trajectories defined in the de Broglie--Bohm theory provide a causal way to interpret physical phenomena. In this Letter, we use this formalism to analyze the short time dynamics induced by unstable periodic orbits in a classically chaotic system, a situation in which scars are known to play a very important role. We find that the topologies of the quantum orbits are much more complicated than that of the scarring and associated periodic orbits, since the former have quantum interference built in. Thus scar wave functions are necessary to analyze the corresponding dynamics. Moreover, these topologies imply different return routes to the vicinity of the initial positions, and this reflects in the existence of different contributions in each peak of the survival probability function.

  3. Geometric methods for discrete dynamical systems

    CERN Document Server

    Easton, Robert W

    1998-01-01

    This book looks at dynamics as an iteration process where the output of a function is fed back as an input to determine the evolution of an initial state over time. The theory examines errors which arise from round-off in numerical simulations, from the inexactness of mathematical models used to describe physical processes, and from the effects of external controls. The author provides an introduction accessible to beginning graduate students and emphasizing geometric aspects of the theory. Conley''s ideas about rough orbits and chain-recurrence play a central role in the treatment. The book will be a useful reference for mathematicians, scientists, and engineers studying this field, and an ideal text for graduate courses in dynamical systems.

  4. Extensions to Dynamic System Simulation of Fissile Solution Systems

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Steven Karl [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bernardin, John David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kimpland, Robert Herbert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Spernjak, Dusan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-08-24

    Previous reports have documented the results of applying dynamic system simulation (DSS) techniques to model a variety of fissile solution systems. The SUPO (Super Power) aqueous homogeneous reactor (AHR) was chosen as the benchmark for comparison of model results to experimental data for steadystate operation.1 Subsequently, DSS was applied to additional AHR to verify results obtained for SUPO and extend modeling to prompt critical excursions, ramp reactivity insertions of various magnitudes and rate, and boiling operations in SILENE and KEWB (Kinetic Experiment Water Boiler).2 Additional models for pressurized cores (HRE: Homogeneous Reactor Experiment), annular core geometries, and accelerator-driven subcritical systems (ADAHR) were developed and results reported.3 The focus of each of these models is core dynamics; neutron kinetics, thermal hydraulics, radiolytic gas generation and transport are coupled to examine the time-based evolution of these systems from start-up through transition to steady-state. A common characteristic of these models is the assumption that (a) core cooling system inlet temperature and flow and (b) plenum gas inlet pressure and flow are held constant; no external (to core) component operations that may result in dynamic change to these parameters are considered. This report discusses extension of models to include explicit reference to cooling structures and radiolytic gas handling. The accelerator-driven subcritical generic system model described in References 3 and 4 is used as a basis for this extension.

  5. Dynamics of Hamiltonian Systems and Memristor Circuits

    Science.gov (United States)

    Itoh, Makoto; Chua, Leon

    In this paper, we show that any n-dimensional autonomous systems can be regarded as subsystems of 2n-dimensional Hamiltonian systems. One of the two subsystems is identical to the n-dimensional autonomous system, which is called the driving system. Another subsystem, called the response system, can exhibit interesting behaviors in the neighborhood of infinity. That is, the trajectories approach infinity with complicated nonperiodic (chaotic-like) behaviors, or periodic-like behavior. In order to show the above results, we project the trajectories of the Hamiltonian systems onto n-dimensional spheres, or n-dimensional balls by using the well-known central projection transformation. Another interesting behavior is that the transient regime of the subsystems can exhibit Chua corsage knots. We next show that generic memristors can be used to realize the above Hamiltonian systems. Finally, we show that the internal state of two-element memristor circuits can have the same dynamics as n-dimensional autonomous systems.

  6. Wind turbine control systems: Dynamic model development using system identification and the fast structural dynamics code

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, J.G.; Wright, A.D.; Butterfield, C.P.

    1996-10-01

    Mitigating the effects of damaging wind turbine loads and responses extends the lifetime of the turbine and, consequently, reduces the associated Cost of Energy (COE). Active control of aerodynamic devices is one option for achieving wind turbine load mitigation. Generally speaking, control system design and analysis requires a reasonable dynamic model of {open_quotes}plant,{close_quotes} (i.e., the system being controlled). This paper extends the wind turbine aileron control research, previously conducted at the National Wind Technology Center (NWTC), by presenting a more detailed development of the wind turbine dynamic model. In prior research, active aileron control designs were implemented in an existing wind turbine structural dynamics code, FAST (Fatigue, Aerodynamics, Structures, and Turbulence). In this paper, the FAST code is used, in conjunction with system identification, to generate a wind turbine dynamic model for use in active aileron control system design. The FAST code is described and an overview of the system identification technique is presented. An aileron control case study is used to demonstrate this modeling technique. The results of the case study are then used to propose ideas for generalizing this technique for creating dynamic models for other wind turbine control applications.

  7. Effect of signal modulating noise in bistable stochastic dynamical systems

    Institute of Scientific and Technical Information of China (English)

    肖方红; 闫桂荣; 张新武

    2003-01-01

    The effect of signal modulating noise in bistable stochastic dynamical systems is studied.The concept of instan taneous steady state is proposed for bistable dynamical systems.By making a dynamical analysis of bistable stochastic systems,we find that global and local effect of signal modulating noise as well as stochastic resonance can occur in bistable dynamical systems on which both a weak sinusoidal signal and noise are forced.The effect is demonstrated by numerical simulation.

  8. Dynamic Analysis of Power System Voltage Stability.

    Science.gov (United States)

    Gebreselassie, Assefa

    This thesis investigates the effects of loads and voltage regulators on the dynamic voltage stability of power systems. The analysis focuses on the interactions of machine flux dynamics with loads and voltage control devices. The results are based on eigenvalue analysis of the linearized models and time simulation of the nonlinear models, using models from the Power System Toolbox, a Matlab -based package for the simulation and small signal analysis of nonlinear power systems. The voltage stability analysis results are developed using a single machine single load system with typical machine and network parameters and the NPCC 10-machine system. Dynamic models for generators, exciters and loads are used. The generator is modeled with a pair of poles and one damper circuit in both the d-axis and the q-axis. Saturation effects are included in the model. The IEEE Type DC1 DC commutator exciter model is used for all the exciters. Five different types of loads: constant impedance, constant current, constant power, a first order induction motor model (slip model) and a third order induction motor model (slip-flux model) are considered. The modes of instability and the stability limits of the different representation of loads are examined for two different operating modes of the exciters. The first, when all the exciters are on automatic control and the second when some exciters are on manual control. Modal participation factors are used to determine the characteristics of the critical modes. The characteristics of the unstable modes are verified by performing time simulation of the nonlinear models. Oscillatory and non-oscillatory instabilities are experienced by load buses when all the exciters are on automatic control and some exciters are on manual control respectively, for loads which are predominantly constant power and induction motors. It is concluded that the mode of instability does not depend on the type of loads but on the operating condition of the exciters

  9. Adaptive information filtering for dynamic recommender systems

    CERN Document Server

    Jin, Ci-Hang; Zhang, Yi-Cheng; Zhou, Tao

    2009-01-01

    The dynamic environment in the real world calls for the adaptive techniques for information filtering, namely to provide real-time responses to the changes of system data. Where many incremental algorithms are designed for this purpose, they are usually challenged by the worse and worse performance resulted from the cumulative errors over time. In this Letter, we propose two incremental diffusion-based algorithms for the personalized recommendations, which integrate some pieces of local and fast updatings to achieve the approximate results. In addition to the fast responses, the errors of the proposed algorithms do not cumulate over time, that is to say, the global recomputing is unnecessary. This remarkable advantage is demonstrated by several metrics on algorithmic accuracy for two movie recommender systems and a social bookmarking system.

  10. Systems approaches to study root architecture dynamics

    Directory of Open Access Journals (Sweden)

    Candela eCuesta

    2013-12-01

    Full Text Available The plant root system is essential for providing anchorage to the soil, supplying minerals and water, and synthesizing metabolites. It is a dynamic organ modulated by external cues such as environmental signals, water and nutrients availability, salinity and others. Lateral roots are initiated from the primary root post-embryonically, after which they progress through discrete developmental stages which can be independently controlled, providing a high level of plasticity during root system formation.Within this review, main contributions are presented, from the classical forward genetic screens to the more recent high-throughput approaches, combined with computer model predictions, dissecting how lateral roots and thereby root system architecture is established and developed.

  11. Chaotic Behavior in a Switched Dynamical System

    Directory of Open Access Journals (Sweden)

    Fatima El Guezar

    2008-01-01

    Full Text Available We present a numerical study of an example of piecewise linear systems that constitute a class of hybrid systems. Precisely, we study the chaotic dynamics of the voltage-mode controlled buck converter circuit in an open loop. By considering the voltage input as a bifurcation parameter, we observe that the obtained simulations show that the buck converter is prone to have subharmonic behavior and chaos. We also present the corresponding bifurcation diagram. Our modeling techniques are based on the new French native modeler and simulator for hybrid systems called Scicos (Scilab connected object simulator which is a Scilab (scientific laboratory package. The followed approach takes into account the hybrid nature of the circuit.

  12. A modular system for computational fluid dynamics

    Science.gov (United States)

    McCarthy, D. R.; Foutch, D. W.; Shurtleff, G. E.

    This paper describes the Modular System for Compuational Fluid Dynamics (MOSYS), a software facility for the construction and execution of arbitrary solution procedures on multizone, structured body-fitted grids. It focuses on the structure and capabilities of MOSYS and the philosophy underlying its design. The system offers different levels of capability depending on the objectives of the user. It enables the applications engineer to quickly apply a variety of methods to geometrically complex problems. The methods developer can implement new algorithms in a simple form, and immediately apply them to problems of both theoretical and practical interest. And for the code builder it consitutes a toolkit for fast construction of CFD codes tailored to various purposes. These capabilities are illustrated through applications to a particularly complex problem encountered in aircraft propulsion systems, namely, the analysis of a landing aircraft in reverse thrust.

  13. Structural system identification: Structural dynamics model validation

    Energy Technology Data Exchange (ETDEWEB)

    Red-Horse, J.R.

    1997-04-01

    Structural system identification is concerned with the development of systematic procedures and tools for developing predictive analytical models based on a physical structure`s dynamic response characteristics. It is a multidisciplinary process that involves the ability (1) to define high fidelity physics-based analysis models, (2) to acquire accurate test-derived information for physical specimens using diagnostic experiments, (3) to validate the numerical simulation model by reconciling differences that inevitably exist between the analysis model and the experimental data, and (4) to quantify uncertainties in the final system models and subsequent numerical simulations. The goal of this project was to develop structural system identification techniques and software suitable for both research and production applications in code and model validation.

  14. Dynamics and Habitability in Binary Star Systems

    CERN Document Server

    Eggl, Siegfried; Pilat-Lohinger, Elke

    2014-01-01

    Determining planetary habitability is a complex matter, as the interplay between a planet's physical and atmospheric properties with stellar insolation has to be studied in a self consistent manner. Standardized atmospheric models for Earth-like planets exist and are commonly accepted as a reference for estimates of Habitable Zones. In order to define Habitable Zone boundaries, circular orbital configurations around main sequence stars are generally assumed. In gravitationally interacting multibody systems, such as double stars, however, planetary orbits are forcibly becoming non circular with time. Especially in binary star systems even relatively small changes in a planet's orbit can have a large impact on habitability. Hence, we argue that a minimum model for calculating Habitable Zones in binary star systems has to include dynamical interactions.

  15. Aging and the germ line: where mortality and immortality meet.

    Science.gov (United States)

    Jones, D Leanne

    2007-01-01

    Germ cells are highly specialized cells that form gametes, and they are the only cells within an organism that contribute genes to offspring. Germline stem cells (GSCs) sustain gamete production, both oogenesis (egg production) and spermatogenesis (sperm production), in many organisms. Since the genetic information contained within germ cells is passed from generation to generation, the germ line is often referred to as immortal. Therefore, it is possible that germ cells possess unique strategies to protect and transmit the genetic information contained within them indefinitely. However, aging often leads to a dramatic decrease in gamete production and fecundity. In addition, single gene mutations affecting longevity often have a converse effect on reproduction. Recent studies examining age-related changes in GSC number and activity, as well as changes to the stem cell microenvironment, provide insights into the mechanisms underlying the observed reduction in gametogenesis over the lifetime of an organism.

  16. Motoneuron differentiation of immortalized human spinal cord cell lines.

    Science.gov (United States)

    Li, R; Thode, S; Zhou, J; Richard, N; Pardinas, J; Rao, M S; Sah, D W

    2000-02-01

    Human motoneuron cell lines will be valuable tools for spinal cord research and drug discovery. To create such cell lines, we immortalized NCAM(+)/neurofilament(+) precursors from human embryonic spinal cord with a tetracycline repressible v-myc oncogene. Clonal NCAM(+)/neurofilament(+) cell lines differentiated exclusively into neurons within 1 week. These neurons displayed extensive processes, exhibited immunoreactivity for mature neuron-specific markers such as tau and synaptophysin, and fired action potentials upon current injection. Moreover, a clonal precursor cell line gave rise to multiple types of spinal cord neurons, including ChAT(+)/Lhx3(+)/Lhx4(+) motoneurons and GABA(+) interneurons. These neuronal restricted precursor cell lines will expedite the elucidation of molecular mechanisms that regulate the differentiation, maturation and survival of specific subsets of spinal cord neurons, and the identification and validation of novel drug targets for motoneuron diseases and spinal cord injury.

  17. Application of spontaneously immortalized odontoblast cells in tooth regeneration.

    Science.gov (United States)

    Arany, Szilvia; Kawagoe, Masami; Sugiyama, Toshihiro

    2009-03-27

    Here, we report on the first attempt to bioengineer tooth using a spontaneously immortalized mesenchymal cell line. To assess the odontogenic potential of this cell line, odontoblast-lineage cells (OLC) were re-associated with competent dental epithelium isolated from E14.5 mice. A novel three-dimensional organ germ culture method was applied to nurture the constructs in vitro. Additionally, recombinants were transplanted under the kidney capsule in host animals for 2 weeks. Transplants developed into tooth tissues in one-third of the cases. OLC-derived GFP-positive cells could be identified in mineralizing tooth germs by immunohistochemistry. OLCs were capable of intercellular and cell-matrix communication, thus they eventually differentiated into functional odontoblasts. In summary, we managed to utilize OLCs for dental mesenchyme substitution in tooth regeneration experiments. Therefore, our spontaneously transformed cell line proved its potential for future complex, tooth developmental and bioengineering studies.

  18. Dynamics of coupled human-landscape systems

    Science.gov (United States)

    Werner, B. T.; McNamara, D. E.

    2007-11-01

    A preliminary dynamical analysis of landscapes and humans as hierarchical complex systems suggests that strong coupling between the two that spreads to become regionally or globally pervasive should be focused at multi-year to decadal time scales. At these scales, landscape dynamics is dominated by water, sediment and biological routing mediated by fluvial, oceanic, atmospheric processes and human dynamics is dominated by simplifying, profit-maximizing market forces and political action based on projection of economic effect. Also at these scales, landscapes impact humans through patterns of natural disasters and trends such as sea level rise; humans impact landscapes by the effect of economic activity and changes meant to mitigate natural disasters and longer term trends. Based on this analysis, human-landscape coupled systems can be modeled using heterogeneous agents employing prediction models to determine actions to represent the nonlinear behavior of economic and political systems and rule-based routing algorithms to represent landscape processes. A cellular model for the development of New Orleans illustrates this approach, with routing algorithms for river and hurricane-storm surge determining flood extent, five markets (home, labor, hotel, tourism and port services) connecting seven types of economic agents (home buyers/laborers, home developers, hotel owners/ employers, hotel developers, tourists, port services developer and port services owners/employers), building of levees or a river spillway by political agents and damage to homes, hotels or port services within cells determined by the passage or depth of flood waters. The model reproduces historical aspects of New Orleans economic development and levee construction and the filtering of frequent small-scale floods at the expense of large disasters.

  19. Immortalized Rat Astrocyte Strain Genetically Modified by Rat Preprogalanin Gene

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    To construct an immortalized rat astrocyte strain genetically modified by rat preprogalanin gene (IAST/GAL) and detect its galanin (GAL) expression and secretion, a cDNA fragment of rat GAL in plasmid of pBS KS(+)-GAL was inserted into eukaryotic expression vector pcDNA3.1(+) by DNA recombinant technology, then the restriction enzyme digestion and DNA sequencing were carried out to evaluate the recombinant. The pcDNA3.1 (+)-GAL and pcDNA3.1 (+) construct were transfected into immortalized rat astrocyte strain (IAST) by lipofectamine and the population of cells which stably integrated the construct was selected with 600 μg/mL G418. Individual clones were screened and expanded into clonal cell strains. Detection of Neo gene was used to validate the success of the transfection. Immunocytochemical staining, RT-PCR and radioimmunoassay were used to detect the expression and secretion level of GAL. The recombinant had been successfully constructed by restriction enzyme digestion and DNA sequencing. Detection of Neo gene showed that the pcDNA3.1 (+)-GAL and pcDNA3.1 (+) have been successfully transfected into IAST. After selection by using G418, IAST/GAL and IAST/Neo cell strains were obtained.IAST/GAL, IAST/Neo and IAST were immunostained positively for GAL, but the GAL average optical density of IAST/GAL was significantly higher than that of IAST/Neo and IAST (P<0.01). The level of GAL mRNA expression and the supernatant concentration of GAL in cultured IAST/GAL were significantly higher than those of IAST and IAST/Neo (P<0.01), but no significant differences were found between the IAST and IAST/Neo (P>0.05). It was concluded that IAST/GAL strain was constructed successfully and it might provide a basis for the further study of pain therapy.

  20. Differential dynamic logics - automated theorem proving for hybrid systems

    OpenAIRE

    Platzer, André

    2008-01-01

    Hybrid systems are models for complex physical systems and are defined as dynamical systems with interacting discrete transitions and continuous evolutions along differential equations. With the goal of developing a theoretical and practical foundation for deductive verification of hybrid systems, we introduce differential dynamic logic as a new logic with which correctness properties of hybrid systems with parameterized system dynamics can be specified and verified naturally. As a verificati...

  1. Qualitative theory of p-adic dynamical systems

    Science.gov (United States)

    Zelenov, E. I.

    2014-02-01

    We consider a class of dynamical systems over the p-adic number field: hierarchical dynamical systems. We prove a strong variant of the Poincaré theorem on the number of returns for such systems and show that hierarchical systems do not admit mixing. We describe hierarchical dynamical systems over the projective line and present an example of a nonhierarchical p-adic system that admits mixing: the p-adic baker's transformation.

  2. Dynamic system evolution and markov chain approximation

    Directory of Open Access Journals (Sweden)

    Roderick V. Nicholas Melnik

    1998-01-01

    Full Text Available In this paper computational aspects of the mathematical modelling of dynamic system evolution have been considered as a problem in information theory. The construction of mathematical models is treated as a decision making process with limited available information.The solution of the problem is associated with a computational model based on heuristics of a Markov Chain in a discrete space–time of events. A stable approximation of the chain has been derived and the limiting cases are discussed. An intrinsic interconnection of constructive, sequential, and evolutionary approaches in related optimization problems provides new challenges for future work.

  3. Advances in dynamical systems and control

    CERN Document Server

    Zgurovsky, Mikhail

    2016-01-01

    Focused on recent advances, this book covers theoretical foundations as well as various applications. It presents modern mathematical modeling approaches to the qualitative and numerical analysis of solutions for complex engineering problems in physics, mechanics, biochemistry, geophysics, biology and climatology. Contributions by an international team of respected authors bridge the gap between abstract mathematical approaches, such as applied methods of modern analysis, algebra, fundamental and computational mechanics, nonautonomous and stochastic dynamical systems on the one hand, and practical applications in nonlinear mechanics, optimization, decision making theory and control theory on the other. As such, the book will be of interest to mathematicians and engineers working at the interface of these fields. .

  4. The self as a complex dynamic system

    Directory of Open Access Journals (Sweden)

    Sarah Mercer

    2011-04-01

    Full Text Available This article explores the potential offered by complexity theories for understanding language learners’ sense of self and attempts to show how the self might usefully be conceived of as a complex dynamic system. Rather than presenting empirical findings, the article discusses existent research on the self and aims at outlining a conceptual perspective that may inform future studies into the self and possibly other individual learner differences. The article concludes by critically considering the merits of a complexity perspective but also reflecting on the challenges it poses for research.

  5. Thermodynamic Cross-Effects from Dynamical Systems

    CERN Document Server

    Matyas, L; Vollmer, J; Matyas, Laszlo; Tel, Tamas; Vollmer, Jurgen

    1999-01-01

    We give a thermodynamically consistent description of simultaneous heat and particle transport, as well as of the associated cross-effects, in the framework of a chaotic dynamical system, a generalized multibaker map. Besides the density, a second field with appropriate source terms is included in order to mimic, after coarse graining, a spatial temperature distribution and its time evolution. A new expression is derived for the irreversible entropy production in a steady state, as the average of the growth rate of the relative density, a unique combination of the two fields.

  6. Dynamic Efficiency of a Container Crane’s Hoisting Transmission System under Hoisting Dynamic Load

    Directory of Open Access Journals (Sweden)

    Yuanyuan Liu

    2016-01-01

    Full Text Available The dynamic efficiency of hoisting transmission system on a container crane is fundamental for accurate efficiency prediction, while the dynamic efficiency of hoisting transmission system has not been investigated sufficiently. This paper will focus on dynamic efficiency of hoisting transmission system under hoisting dynamic load. A power loss model of gearbox was built. Then the dynamic model of gear transmission was developed including time-varying mesh stiffness and hoisting dynamic load was studied. Power loss, dynamic efficiency, and equivalent static efficiency were conducted in hoisting and lowering working conditions. The result shows that dynamic efficiency which consists of the significant lower frequency component coincided with hoisting load torque of the higher frequency component which is directly related to dynamic mesh and bearing force. And in two processes, the equivalent static efficiency in constant speed stage is min, whereas maximum value occurs in different stage. The research results lay a foundation for hoisting gear transmission dynamic efficiency analysis.

  7. Allocation of Resources Dynamically In Cloud Systems

    Directory of Open Access Journals (Sweden)

    D. Sivapriyanka,

    2014-05-01

    Full Text Available Cloud Computing is a newly evolving platform that can be accessed as a service by the users. It is used as storage for files, applications and infrastructure through the Internet. User can access everything as a service in on-demand basis named as pay-as-you-go model. Service-oriented Architecture (SOA has been adopted in diverse circulated systems such as World Wide Web services, grid computing schemes, utility computing systems and cloud computing schemes. These schemes are called as Service Oriented Systems. One of the open issues is to prioritize service requests in dynamically altering environments where concurrent instances of processes may compete for assets. If we want to prioritize the request, we need to monitor the assets that the cloud services have and founded on the available assets the demanded assets can be assigned to the user. Hence, we propose an approach to find present status of the system by utilizing Dynamic Adaptation Approach. The major target of the research work is to prioritize the service demand, which maximizes the asset utilization in an effective kind that decreases the penalty function for the delayed service. The main concerns should be allotted to requests founded on promise violations of SLA objectives. While most existing work in the area of quality of service supervising and SLA modeling focuses normally on purely mechanical schemes, we consider service-oriented systems spanning both programs founded services and human actors. Our approach deals with these challenges and assigns priority to the requested service to avoid service delay using Prioritization Algorithm.

  8. On the Theory of Nonlinear Dynamics and its Applications in Vehicle Systems Dynamics

    DEFF Research Database (Denmark)

    True, Hans

    1999-01-01

    We present a brief outline of nonlinear dynamics and its applications to vehicle systems dynamics problems. The concept of a phase space is introduced in order to illustrate the dynamics of nonlinear systems in a way that is easy to perceive. Various equilibrium states are defined...... of nonlinear dynamics in vehicle simulations is discussed, and it is argued that it is necessary to know the equilibrium states of the full nonlinear system before the simulation calculations are performed....

  9. Dynamical flexibility of torsionally vibrating mechatronic system

    Directory of Open Access Journals (Sweden)

    A. Buchacz

    2008-01-01

    Full Text Available Purpose: of this paper is the application of the approximate method called Galerkin’s method to solve the task of assigning the frequency-modal analysis and characteristics of a mechatronic system.Design/methodology/approach: was the formulated and solved as a problem in the form of a set of differential equations of the considered mechatronic model of an object. To obtain the solution, Galerkin’s method was used. The discussed torsionally vibrating mechatronic system consists of mechanical system, which is a continuous bar of circular cross-section, clamped on its ends. The electrical subsystem of the considered mechatronic system is a ring transducer to be perfectly bonded to the bar surface.Findings: this study is that the parameters of the transducer have an important influence on the values of natural frequencies and on the form of the characteristics of the said mechatronic system. The results of the calculations were not only presented in a mathematical form but also as transients of the examined dynamical characteristic which are a function of frequency of the assumed excitation.Research limitations/implications: is that the linear mechatronic system was considered, for this type of systems, such approach is sufficient.Practical implications: of this researches was that another approach is presented, that means in the domain of frequency spectrum analysis. The method used and the obtained results can be of some value for designers of mechatronic systems.Originality/value: of this paper is that the mechatronic system, created from mechanical and electrical subsystems with electromechanical bondage was examined. This approach is other than those considered elsewhere.

  10. Scalable persistent identifier systems for dynamic datasets

    Science.gov (United States)

    Golodoniuc, P.; Cox, S. J. D.; Klump, J. F.

    2016-12-01

    Reliable and persistent identification of objects, whether tangible or not, is essential in information management. Many Internet-based systems have been developed to identify digital data objects, e.g., PURL, LSID, Handle, ARK. These were largely designed for identification of static digital objects. The amount of data made available online has grown exponentially over the last two decades and fine-grained identification of dynamically generated data objects within large datasets using conventional systems (e.g., PURL) has become impractical. We have compared capabilities of various technological solutions to enable resolvability of data objects in dynamic datasets, and developed a dataset-centric approach to resolution of identifiers. This is particularly important in Semantic Linked Data environments where dynamic frequently changing data is delivered live via web services, so registration of individual data objects to obtain identifiers is impractical. We use identifier patterns and pattern hierarchies for identification of data objects, which allows relationships between identifiers to be expressed, and also provides means for resolving a single identifier into multiple forms (i.e. views or representations of an object). The latter can be implemented through (a) HTTP content negotiation, or (b) use of URI querystring parameters. The pattern and hierarchy approach has been implemented in the Linked Data API supporting the United Nations Spatial Data Infrastructure (UNSDI) initiative and later in the implementation of geoscientific data delivery for the Capricorn Distal Footprints project using International Geo Sample Numbers (IGSN). This enables flexible resolution of multi-view persistent identifiers and provides a scalable solution for large heterogeneous datasets.

  11. Covariant GNS Representation for C*-Dynamical Systems

    CERN Document Server

    Pandiscia, Carlo

    2012-01-01

    We extend the covariant GNS representation of Niculescu, Str\\"oh and Zsid\\'o for C*-dynamical systems with time-evolution of the system (dynamics) a homomorphism of C*-algebras, to any dynamical systems, where the dynamics is an unital completely positive map. We give also an overview on its application to the reversible dilation theory as formulated by B. Kummerer.

  12. Adding Dynamic Innovation to Environmental Management Systems

    DEFF Research Database (Denmark)

    Schmidt, Kirsten

    to the ongoing development of the organization? Based on a case study in a global, but Danish based production company, the paper discusses the development of more dynamic, yet still systematic, environmental effort in organizations by introducing a matrix structure of the environmental management. In the matrix......Over the last two decades, a number of organizations have implemented Environmental Management Systems (EMS) to assure a systematic approach and continuous improvements. Such systems include a number of “rules” for specific actions to be taken by members of the organization in given situations....... While such procedures may ensure a certain level of environmental effort they also tend to favor a learning style in the organization based on optimization of already known actions. This is among other things due to the fact that a certified EMS should include regular audits, and to the people...

  13. On Fixed Points of Linguistic Dynamic Systems

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Linguistic dynamic systems (LDS) are dynamic systems whose state variables are generalized from numbers to words. Generally speaking, LDS can model all evolving processes in word domains by using linguistic evolving laws which are naturally the linguistic extension of evolving laws in numbers. There are two kinds of LDS; namely, type-I and type-II LDS. If the word domain is modeled by fuzzy sets, then the evolving laws of a type-I LDS are constructed by applying the fuzzy extension principle to those of its conventional counterpart. On the other hand, the evolving laws of a type-II LDS are modeled by fuzzy if/then rules. Note that the state spaces of both type-I and type-II LDSs are word continuum. However, in practice, the representation of the state space of a type-II LDS consists of finite number while its computation actually involves a word continuum. In this paper, the existence of fixed points of type-II LDS is studied based on point-to-fuzzy-set mappings. The properties of the fixed point of type-II LDS are also studied. In addition, linguistic controllers are designed to control type-II LDS to goal states specified in words.

  14. Major depression as a complex dynamical system

    CERN Document Server

    Cramer, Angélique O J; Giltay, Erik J; van der Maas, Han L J; Kendler, Kenneth S; Scheffer, Marten; Borsboom, Denny

    2016-01-01

    In this paper, we characterize major depression (MD) as a complex dynamical system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulting dynamics. With respect to architecture, we show that individuals vulnerable to developing MD are those with strong connections between symptoms: e.g., only one night of poor sleep suffices to make a particular person feel tired. Such vulnerable networks, when pushed by forces external to the system such as stress, are more likely to end up in a depressed state; whereas networks with weaker connections tend to remain in or return to a healthy state. We show this with a simulation in which we model the probability of a symptom becoming active as a logistic function of the activity of its neighboring symptoms. Additionally, we show that this model potentially explains some well-known empirical phenomena such as s...

  15. Dynamical Systems Approach to Magnetised Cosmological Perturbations

    CERN Document Server

    Hobbs, S; Hobbs, Stacey; Dunsby, Peter K. S.

    2000-01-01

    Assuming a large-scale homogeneous magnetic field, we follow the covariant and gauge-invariant approach used by Tsagas and Barrow to describe the evolution of density and magnetic field inhomogeneities and curvature perturbations in a matter-radiation universe. We use a two parameter approximation scheme to linearize their exact non-linear general-relativistic equations for magneto-hydrodynamic evolution. Using a two-fluid approach we set up the governing equations as a fourth order autonomous dynamical system. Analysis of the equilibrium points for the radiation dominated era lead to solutions similar to the super-horizon modes found analytically by Tsagas and Maartens. We find that a study of the dynamical system in the dust-dominated era leads naturally to a magnetic critical length scale closely related to the Jeans Length. Depending on the size of wavelengths relative to this scale, these solutions show three distinct behaviours: large-scale stable growing modes, intermediate decaying modes, and small-sc...

  16. Disease processes as hybrid dynamical systems

    Directory of Open Access Journals (Sweden)

    Pietro Liò

    2012-08-01

    Full Text Available We investigate the use of hybrid techniques in complex processes of infectious diseases. Since predictive disease models in biomedicine require a multiscale approach for understanding the molecule-cell-tissue-organ-body interactions, heterogeneous methodologies are often employed for describing the different biological scales. Hybrid models provide effective means for complex disease modelling where the action and dosage of a drug or a therapy could be meaningfully investigated: the infection dynamics can be classically described in a continuous fashion, while the scheduling of multiple treatment discretely. We define an algebraic language for specifying general disease processes and multiple treatments, from which a semantics in terms of hybrid dynamical system can be derived. Then, the application of control-theoretic tools is proposed in order to compute the optimal scheduling of multiple therapies. The potentialities of our approach are shown in the case study of the SIR epidemic model and we discuss its applicability on osteomyelitis, a bacterial infection affecting the bone remodelling system in a specific and multiscale manner. We report that formal languages are helpful in giving a general homogeneous formulation for the different scales involved in a multiscale disease process; and that the combination of hybrid modelling and control theory provides solid grounds for computational medicine.

  17. Dynamics of human respiratory system mycoflora

    Directory of Open Access Journals (Sweden)

    Anna Biedunkiewicz

    2014-08-01

    Full Text Available The study aimed at determing the prevalence of individual species of fungi in the respiratory systems of women and men, analysis of the dynamics of the fungi in individual sections of the respiratory system as concerns their quantity and identification of phenology of the isolated fungi coupled with an attempt at identifying their possible preferences for appearing during specific seasons of thc year. During 10 years of studies (1989- 1998. 29 species of fungi belonging: Candida, Geolrichum, Saccharomyces, Saccharomycopsis, Schizosaccharomyces, Torulopsis, Trichosporon and Aspergillus were isolated from the ontocenoses of the respiratory systems of patients at the Independent Public Center for Pulmonology and Oncology in Olsztyn. Candida albicans was a clearly dominating fungus. Individual species appeared individually, in twos or threes in a single patient, they were isolated more frequently in the spring and autumn, less frequently during the winter and summer. The largest number of fungi species were isolated from sputum (29 species, bronchoscopic material (23 species and pharyngeal swabs (15 species. Sacchoromycopsis capsularis and Trichosporon beigelii should be treated as new for the respiratory system. Biodiversity of fungi, their numbers and continous fluctuations in frequency indicate that the respiratory system ontocenose offers the optimum conditions for growth and development of the majority of the majority of yeasts - like fungi.

  18. Dissipative dynamics of superconducting hybrid qubit systems

    Energy Technology Data Exchange (ETDEWEB)

    Montes, Enrique; Calero, Jesus M; Reina, John H, E-mail: enriquem@univalle.edu.c, E-mail: j.reina-estupinan@physics.ox.ac.u [Departamento de Fisica, Universidad del Valle, A.A. 25360, Cali (Colombia)

    2009-05-01

    We perform a theoretical study of composed superconducting qubit systems for the case of a coupled qubit configuration based on a hybrid qubit circuit made of both charge and phase qubits, which are coupled via a sigma{sub x} x sigma{sub z} interaction. We compute the system's eigen-energies in terms of the qubit transition frequencies and the strength of the inter-qubit coupling, and describe the sensitivity of the energy crossing/anti-crossing features to such coupling. We compute the hybrid system's dissipative dynamics for the cases of i) collective and ii) independent decoherence, whereby the system interacts with one common and two different baths of harmonic oscillators, respectively. The calculations have been performed within the Bloch-Redfield formalism and we report the solutions for the populations and the coherences of the system's reduced density matrix. The dephasing and relaxation rates are explicitly calculated as a function of the heat bath temperature.

  19. On Dynamic Systems with Piecewise Linear Feature

    Directory of Open Access Journals (Sweden)

    Amalia Ţîrdea

    2010-10-01

    Full Text Available Impact dynamics is considered to be one of the most important problems which arise in vibrating systems. Such impact oscillator occurs in the motion with amplitude constraining stop. In the past years, this simple model has been found rich phenomena and given benefit for understanding of impact systems. Different types of impacting response, such as periodic and non-periodic oscillations, can be predicted by using bifurcation diagrams. Many mechanical systems in engineering applications represent systems which are driven in some way and which undergo intermittent or a continuous sequence of contacts with limiting motion by constraints. For example, the principles of the operation of vibration hammers, impact dampers, inertial shakers, milling and forming machines etc, are based on the impact action for moving bodies. With other equipment, machines with clearances, heat exchangers, steam generator tubes, fuel rods in nuclear power plants, rolling railway wheel sets, piping systems, gear transmissions and so on, impacts also occur, but they are undesirable as they bring about failures, strains, and increased noise levels.

  20. On Nonnegative Solutions of Fractional q-Linear Time-Varying Dynamic Systems with Delayed Dynamics

    Directory of Open Access Journals (Sweden)

    M. De la Sen

    2014-01-01

    Full Text Available This paper is devoted to the investigation of nonnegative solutions and the stability and asymptotic properties of the solutions of fractional differential dynamic linear time-varying systems involving delayed dynamics with delays. The dynamic systems are described based on q-calculus and Caputo fractional derivatives on any order.

  1. Response and Reliability Problems of Dynamic Systems

    DEFF Research Database (Denmark)

    Nielsen, Søren R. K.

    The present thesis consists of selected parts of the work performed by the author on stochastic dynamics and reliability theory of dynamically excited structures primarily during the period 1986-1996.......The present thesis consists of selected parts of the work performed by the author on stochastic dynamics and reliability theory of dynamically excited structures primarily during the period 1986-1996....

  2. A Dynamic Systems Theory approach to second language acquisition

    NARCIS (Netherlands)

    de Bot, K.; Lowie, W.M.; Verspoor, M.H.

    In this article it is argued that language can be seen as a dynamic system, i.e. a set of variables that interact over time, and that language development can be seen as a dynamic process. Language development shows some of the core characteristics of dynamic systems: sensitive dependence on initial

  3. A Dynamic Systems Theory approach to second language acquisition

    NARCIS (Netherlands)

    de Bot, K.; Lowie, W.M.; Verspoor, M.H.

    2007-01-01

    In this article it is argued that language can be seen as a dynamic system, i.e. a set of variables that interact over time, and that language development can be seen as a dynamic process. Language development shows some of the core characteristics of dynamic systems: sensitive dependence on initial

  4. Dynamic handling control system and assistance systems; Fahrdynamikregelsystem und Assistenzsysteme

    Energy Technology Data Exchange (ETDEWEB)

    Steiner, M.; Baumann, M.; Regensburger, U.; Schmid, V.; Haemmerling, C.; Seekircher, J.; Reichmann, M.; Kiesewetter, W. [DaimlerChrysler AG (Germany)

    2005-10-01

    For the new Mercedes-Benz S-Class the well-known ESP was further developed into the Adaptive Brake. For this purpose dynamic handling functions, such as the ESP vehicle-trailer stabilization, and added value functions, such as hold and pre-filling, were added. Innovative assistance systems like brake assist BAS Plus, adaptive cruise control system Distronic Plus and night view assist can see with 'high-tech eyes' on the basis of radar and infrared technology and offer an unprecedented support to the driver in conjunction with ABR. (orig.)

  5. Maximal aggregation of polynomial dynamical systems.

    Science.gov (United States)

    Cardelli, Luca; Tribastone, Mirco; Tschaikowski, Max; Vandin, Andrea

    2017-09-19

    Ordinary differential equations (ODEs) with polynomial derivatives are a fundamental tool for understanding the dynamics of systems across many branches of science, but our ability to gain mechanistic insight and effectively conduct numerical evaluations is critically hindered when dealing with large models. Here we propose an aggregation technique that rests on two notions of equivalence relating ODE variables whenever they have the same solution (backward criterion) or if a self-consistent system can be written for describing the evolution of sums of variables in the same equivalence class (forward criterion). A key feature of our proposal is to encode a polynomial ODE system into a finitary structure akin to a formal chemical reaction network. This enables the development of a discrete algorithm to efficiently compute the largest equivalence, building on approaches rooted in computer science to minimize basic models of computation through iterative partition refinements. The physical interpretability of the aggregation is shown on polynomial ODE systems for biochemical reaction networks, gene regulatory networks, and evolutionary game theory.

  6. A network-based dynamical ranking system

    CERN Document Server

    Motegi, Shun

    2012-01-01

    Ranking players or teams in sports is of practical interests. From the viewpoint of networks, a ranking system is equivalent a centrality measure for sports networks, whereby a directed link represents the result of a single game. Previously proposed network-based ranking systems are derived from static networks, i.e., aggregation of the results of games over time. However, the score (i.e., strength) of a player, for example, depends on time. Defeating a renowned player in the peak performance is intuitively more rewarding than defeating the same player in other periods. To account for this factor, we propose a dynamic variant of such a network-based ranking system and apply it to professional men's tennis data. Our ranking system, also interpreted as a centrality measure for directed temporal networks, has two parameters. One parameter represents the exponential decay rate of the past score, and the other parameter controls the effect of indirect wins on the score. We derive a set of linear online update equ...

  7. Dynamics of the Yellowstone hydrothermal system

    Science.gov (United States)

    Hurwitz, Shaul; Lowenstern, Jacob B.

    2014-01-01

    The Yellowstone Plateau Volcanic Field is characterized by extensive seismicity, episodes of uplift and subsidence, and a hydrothermal system that comprises more than 10,000 thermal features, including geysers, fumaroles, mud pots, thermal springs, and hydrothermal explosion craters. The diverse chemical and isotopic compositions of waters and gases derive from mantle, crustal, and meteoric sources and extensive water-gas-rock interaction at variable pressures and temperatures. The thermal features are host to all domains of life that utilize diverse inorganic sources of energy for metabolism. The unique and exceptional features of the hydrothermal system have attracted numerous researchers to Yellowstone beginning with the Washburn and Hayden expeditions in the 1870s. Since a seminal review published a quarter of a century ago, research in many fields has greatly advanced our understanding of the many coupled processes operating in and on the hydrothermal system. Specific advances include more refined geophysical images of the magmatic system, better constraints on the time scale of magmatic processes, characterization of fluid sources and water-rock interactions, quantitative estimates of heat and magmatic volatile fluxes, discovering and quantifying the role of thermophile microorganisms in the geochemical cycle, defining the chronology of hydrothermal explosions and their relation to glacial cycles, defining possible links between hydrothermal activity, deformation, and seismicity; quantifying geyser dynamics; and the discovery of extensive hydrothermal activity in Yellowstone Lake. Discussion of these many advances forms the basis of this review.

  8. Wind energy conversion. Volume IV. Drive system dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Sanchez, M.; Labuszewski, T.

    1978-09-01

    The dynamics of the drive system and various approaches to power transmission are described. The effects on performance of using a constant rotor speed as opposed to a rotor speed varying with the wind speed are discussed for various rotor operating schedules and typical wind distributions. The dynamics of the combined rotor, alternator, and drive system are analyzed. Conditions which could lead to electro-dynamic instabilities and desynchronization are discussed as well as means for stabilizing the system. The dynamics of the drive system and important design conditions for various drive systems are discussed, such as location of the alternators, use of hydraulic drive systems and smoothing techniques.

  9. Genetic Algorithms in Dynamical Systems Optimisation and Adaptation

    NARCIS (Netherlands)

    Reus, N.M. de; Visser, E.K.; Bruggeman, B.

    1998-01-01

    Both in the design of dynamical systems, ranging from control systems to state estimators as in the adaptation of these systems the use of genetic algorithms is worth studying. This paper presents some approaches for using genetic algorithms in dynamical systems. The layouts and specific uses are di

  10. Dynamic management of sustainable development methods for large technical systems

    CERN Document Server

    Krishans, Zigurds; Merkuryev, Yuri; Oleinikova, Irina

    2014-01-01

    Dynamic Management of Sustainable Development presents a concise summary of the authors' research in dynamic methods analysis of technical systems development. The text illustrates mathematical methods, with a focus on practical realization and applications.

  11. Advances in dynamic network modeling in complex transportation systems

    CERN Document Server

    Ukkusuri, Satish V

    2013-01-01

    This book focuses on the latest in dynamic network modeling, including route guidance and traffic control in transportation systems and other complex infrastructure networks. Covers dynamic traffic assignment, flow modeling, mobile sensor deployment and more.

  12. The conserved mitochondrial gene distribution in relatives of Turritopsis nutricula, an immortal jellyfish

    National Research Council Canada - National Science Library

    Devarapalli, Pratap; Kumavath, Ranjith N; Barh, Debmalya; Azevedo, Vasco

    2014-01-01

    Turritopsis nutricula (T. nutricula) is the one of the known reported organisms that can revert its life cycle to the polyp stage even after becoming sexually mature, defining itself as the only immortal organism in the animal kingdom...

  13. Impulsive Stabilization of Uncertain Dynamical Systems and Chaos Control

    Institute of Scientific and Technical Information of China (English)

    LIUBin; YAOJian; FANGJinqing; LIUXinzhi

    2004-01-01

    In this paper, a general impulsive control problem for uncertain dynamical systems is investigated.By utilizing the method of Lyapunov functions, a set of stability criteria for uncertain impulsive dynamical systems are established. These obtained results are then appliedto derive conditions under which an uncertain dynamical system can be robustly stabilized by an impulsive control law. Finally, we demonstrate our method by controlling the famous Lorenz system with uncertain perturbation.

  14. Regularities in the dynamics and development of the International System

    CERN Document Server

    Piepers, Ingo

    2014-01-01

    A finite-time singularity accompanied by log-periodic oscillations shaped the war dynamics and development of the International System during the period 1495 - 1945. The identification of this singularity provides us with a perspective to penetrate and decode the dynamics of the International System. Various regularities in the dynamics of the International System can be identified. These regularities are remarkably consistent, and can be attributed to the connectivity and the growth of connectivity of the International System.

  15. Dynamical Systems, Cytokine Storms, and Blood Filtration

    Science.gov (United States)

    Foster, Glenn; Hubler, Alfred

    2008-03-01

    Various infections and non-infectious diseases can trigger immune cells and the proteins (cytokines) the cells use to communicate with each other to be caught in a positive feedback loop; this ``cytokine storm'' is frequently fatal. By examining the network of cytokine-immune cell interactions we will illustrate why anti-mediator drugs have been generally ineffective in stopping this feedback. A more effective approach may be to try and reduce interactions by dampening many signals at once by filtering the cytokines out of the blood directly (think dialysis). We will argue that feedback on an out of control nonlinear dynamical system is easier to understand than its normal healthy state and apply filtration to a toy model of immune response.

  16. Dynamics of ranking processes in complex systems.

    Science.gov (United States)

    Blumm, Nicholas; Ghoshal, Gourab; Forró, Zalán; Schich, Maximilian; Bianconi, Ginestra; Bouchaud, Jean-Philippe; Barabási, Albert-László

    2012-09-21

    The world is addicted to ranking: everything, from the reputation of scientists, journals, and universities to purchasing decisions is driven by measured or perceived differences between them. Here, we analyze empirical data capturing real time ranking in a number of systems, helping to identify the universal characteristics of ranking dynamics. We develop a continuum theory that not only predicts the stability of the ranking process, but shows that a noise-induced phase transition is at the heart of the observed differences in ranking regimes. The key parameters of the continuum theory can be explicitly measured from data, allowing us to predict and experimentally document the existence of three phases that govern ranking stability.

  17. Dynamics of delayed piecewise linear systems

    Directory of Open Access Journals (Sweden)

    Laszlo E. Kollar

    2003-02-01

    Full Text Available In this paper the dynamics of the controlled pendulum is investigated assuming backlash and time delays. The upper equilibrium of the pendulum is stabilized by a piecewise constant control force which is the linear combination of the sampled values of the angle and the angular velocity of the pendulum. The control force is provided by a motor which drives one of the wheels of the cart through an elastic teeth belt. The contact between the teeth of the gear (rigid and the belt (elastic introduces a nonlinearity known as ``backlash" and causes the oscillation of the controlled pendulum around its upper equilibrium. The processing and sampling delays in the determination of the control force tend to destabilize the controlled system as well. We obtain conditions guaranteeing that the pendulum remains in the neighborhood of the upper equilibrium. Experimental findings obtained on a computer controlled inverted pendulum cart structure are also presented showing good agreement with the simulation results.

  18. The GBT Dynamic Scheduling System: An Update

    Science.gov (United States)

    Clark, M. H.; Balser, D. S.; Braatz, J.; Condon, J.; Creager, R. E.; McCarty, M. T.; Maddalena, R. J.; Marganian, P.; O'Neil, K.; Sessoms, E.; Shelton, A. L.

    2011-07-01

    The Robert C. Byrd Green Bank Telescope's (GBT) Dynamic Scheduling System (DSS), in production use since September 2009, was designed to maximize observing efficiency while maintaining the GBT's flexibility, improving data quality, and minimizing any undue adversity for the observers. Using observing criteria, observer availability and qualifications, three-dimensional weather forecasts, and telescope state, the DSS software is capable of optimally scheduling observers 24 to 48 hours in advance on a telescope having a wide-range of capabilities in a geographical location with variable weather patterns. Recent improvements for the GBT include an expanded frequency coverage (0.390-90 GHz), proper treatment of fully sampled array receivers, increasingly diverse observing criteria, the ability to account for atmospheric instability from clouds, and new tools for scheduling staff to control and interact with generated schedules and the underlying database.

  19. Autonomous learning by simple dynamical systems with delayed feedback.

    Science.gov (United States)

    Kaluza, Pablo; Mikhailov, Alexander S

    2014-09-01

    A general scheme for the construction of dynamical systems able to learn generation of the desired kinds of dynamics through adjustment of their internal structure is proposed. The scheme involves intrinsic time-delayed feedback to steer the dynamics towards the target performance. As an example, a system of coupled phase oscillators, which can, by changing the weights of connections between its elements, evolve to a dynamical state with the prescribed (low or high) synchronization level, is considered and investigated.

  20. STABILITY ANALYSIS OF THE DYNAMIC INPUT-OUTPUT SYSTEM

    Institute of Scientific and Technical Information of China (English)

    GuoChonghui; TangHuanwen

    2002-01-01

    The dynamic input-output model is well known in economic theory and practice. In this paper, the asymptotic stability and balanced growth solutions of the dynamic input-output system are considered. Under some natural assumptions which do not require the technical coefficient matrix to be indecomposable,it has been proved that the dynamic input-output system is not asymptotically stable and the closed dynamic input-output model has a balanced growth solution.

  1. Transport and Dynamics in Toroidal Fusion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Sovinec, Carl [Univ. of Wisconsin, Madison, WI (United States)

    2016-09-07

    The study entitled, "Transport and Dynamics in Toroidal Fusion Systems," (TDTFS) applied analytical theory and numerical computation to investigate topics of importance to confining plasma, the fourth state of matter, with magnetic fields. A central focus of the work is how non-thermal components of the ion particle distribution affect the "sawtooth" collective oscillation in the core of the tokamak magnetic configuration. Previous experimental and analytical research had shown and described how the oscillation frequency decreases and amplitude increases, leading to "monster" or "giant" sawteeth, when the non-thermal component is increased by injecting particle beams or by exciting ions with imposed electromagnetic waves. The TDTFS study applied numerical computation to self-consistently simulate the interaction between macroscopic collective plasma dynamics and the non-thermal particles. The modeling used the NIMROD code [Sovinec, Glasser, Gianakon, et al., J. Comput. Phys. 195, 355 (2004)] with the energetic component represented by simulation particles [Kim, Parker, Sovinec, and the NIMROD Team, Comput. Phys. Commun. 164, 448 (2004)]. The computations found decreasing growth rates for the instability that drives the oscillations, but they were ultimately limited from achieving experimentally relevant parameters due to computational practicalities. Nonetheless, this effort provided valuable lessons for integrated simulation of macroscopic plasma dynamics. It also motivated an investigation of the applicability of fluid-based modeling to the ion temperature gradient instability, leading to the journal publication [Schnack, Cheng, Barnes, and Parker, Phys. Plasmas 20, 062106 (2013)]. Apart from the tokamak-specific topics, the TDTFS study also addressed topics in the basic physics of magnetized plasma and in the dynamics of the reversed-field pinch (RFP) configuration. The basic physics work contributed to a study of two-fluid effects on interchange dynamics, where

  2. Coupled dynamic systems and Le Chatelier's principle in noise control

    Science.gov (United States)

    Maidanik, G.; Becker, K. J.

    2004-05-01

    Investigation of coupling an externally driven dynamic system-a master dynamic system-to a passive one-an adjunct dynamic system-reveals that the response of the adjunct dynamic system affects the precoupled response of the master dynamic system. The responses, in the two dynamic systems when coupled, are estimated by the stored energies (Es) and (E0), respectively. Since the adjunct dynamic system, prior to coupling, was with zero (0) stored energy, E0s=0, the precoupled stored energy (E00) in the master dynamic system is expected to be reduced to (E0) when coupling is instituted; i.e., one expects E0dynamic system would result from the coupling. It is argued that the change in the disposition of the stored energies as just described may not be the only change. The coupling may influence the external input power into the master dynamic system which may interfere with the expected noise control. Indeed, the coupling may influence the external input power such that the expected beneficial noise control may not materialize. Examples of these kinds of noise control reversals are cited.

  3. Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis.

    Science.gov (United States)

    Yildiz, Gokhan; Arslan-Ergul, Ayca; Bagislar, Sevgi; Konu, Ozlen; Yuzugullu, Haluk; Gursoy-Yuzugullu, Ozge; Ozturk, Nuri; Ozen, Cigdem; Ozdag, Hilal; Erdal, Esra; Karademir, Sedat; Sagol, Ozgul; Mizrak, Dilsa; Bozkaya, Hakan; Ilk, Hakki Gokhan; Ilk, Ozlem; Bilen, Biter; Cetin-Atalay, Rengul; Akar, Nejat; Ozturk, Mehmet

    2013-01-01

    Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed to bypass the senescence barrier (become "immortal") by inactivating growth control genes such as TP53 and CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition is accompanied by major phenotypic and biochemical changes mediated by genome-wide transcriptional modifications. This appears to happen during hepatocellular carcinoma (HCC) development in patients with liver cirrhosis, however, the accompanying transcriptional changes are virtually unknown. We investigated genome-wide transcriptional changes related to the senescence-to-immortality switch during hepatocellular carcinogenesis. Initially, we performed transcriptome analysis of senescent and immortal clones of Huh7 HCC cell line, and identified genes with significant differential expression to establish a senescence-related gene list. Through the analysis of senescence-related gene expression in different liver tissues we showed that cirrhosis and HCC display expression patterns compatible with senescent and immortal phenotypes, respectively; dysplasia being a transitional state. Gene set enrichment analysis revealed that cirrhosis/senescence-associated genes were preferentially expressed in non-tumor tissues, less malignant tumors, and differentiated or senescent cells. In contrast, HCC/immortality genes were up-regulated in tumor tissues, or more malignant tumors and progenitor cells. In HCC tumors and immortal cells genes involved in DNA repair, cell cycle, telomere extension and branched chain amino acid metabolism were up-regulated, whereas genes involved in cell signaling, as well as in drug, lipid, retinoid and glycolytic metabolism were down-regulated. Based on these distinctive gene expression features we developed a 15-gene

  4. Dynamical systems and spherically symmetric cosmological models

    Science.gov (United States)

    He, Yanjing

    2006-06-01

    In this thesis we present a study of the timelike self-similar spherically symmetric cosmological models with two scalar fields with exponential potentials. We first define precisely the timelike self-similar spherically symmetric (TSS) spacetimes. We write the TSS metric in a conformally isometric form in a coordinate system adapted to the geometry of the spacetime manifold. In this coordinate system, both the metric functions of the TSS spacetimes and the potential functions of the scalar fields can be simplified to four undetermined functions of a single coordinate. As a result, the Einstein field equations reduce to an autonomous system of first-order ODEs and polynomial constraints in terms of these undetermined functions. By introducing new bounded variables as well as a new independent variable and solving the constraints, we are able to apply the theory of dynamical systems to study the properties of the TSS solutions. By finding invariant sets and associated monotonic functions, by applying the LaSalle Invariance Principle and the Monotonicity Principle, by applying the [straight phi] t -connected property of a limit set, and using other theorems, we prove that all of the TSS trajectories are heteroclinic trajectories. In addition, we conduct numerical simulations to confirm and support the qualitative analysis. We obtain all possible types of TSS solutions, by analyzing the qualitative behavior of the original system of ODES from those of the reduced one. We obtain asymptotic expressions for the TSS solutions (e.g., the asymptotic expressions for the metric functions, the source functions and the Ricci scalar). In particular, self-similar flat Friedmann-Robertson-Walker spacetimes are examined in order to obtain insights into the issues related to the null surface in general TSS spacetimes in these coordinates. A discussion of the divergence of the spacetime Ricci scalar and the possible extension of the TSS solutions across the null boundary is presented

  5. Fluid flow dynamics in MAS systems.

    Science.gov (United States)

    Wilhelm, Dirk; Purea, Armin; Engelke, Frank

    2015-08-01

    The turbine system and the radial bearing of a high performance magic angle spinning (MAS) probe with 1.3mm-rotor diameter has been analyzed for spinning rates up to 67kHz. We focused mainly on the fluid flow properties of the MAS system. Therefore, computational fluid dynamics (CFD) simulations and fluid measurements of the turbine and the radial bearings have been performed. CFD simulation and measurement results of the 1.3mm-MAS rotor system show relatively low efficiency (about 25%) compared to standard turbo machines outside the realm of MAS. However, in particular, MAS turbines are mainly optimized for speed and stability instead of efficiency. We have compared MAS systems for rotor diameter of 1.3-7mm converted to dimensionless values with classical turbomachinery systems showing that the operation parameters (rotor diameter, inlet mass flow, spinning rate) are in the favorable range. This dimensionless analysis also supports radial turbines for low speed MAS probes and diagonal turbines for high speed MAS probes. Consequently, a change from Pelton type MAS turbines to diagonal turbines might be worth considering for high speed applications. CFD simulations of the radial bearings have been compared with basic theoretical values proposing considerably smaller frictional loss values. The discrepancies might be due to the simple linear flow profile employed for the theoretical model. Frictional losses generated inside the radial bearings result in undesired heat-up of the rotor. The rotor surface temperature distribution computed by CFD simulations show a large temperature gradient over the rotor.

  6. On the Relaxation Dynamics of Disordered Systems

    Science.gov (United States)

    Dobramysl, Ulrich

    We investigate the properties of two distinct disordered systems: the two-species predator-prey Lotka-Volterra model with rate variability, and an elastic line model to simulate vortex lines in type-II superconductors. We study the effects of intrinsic demographic variability with inheritance in the reaction rates of the Lotka-Volterra model via zero-dimensional Monte Carlo simulations as well as two-dimensional lattice simulations. Individuals of each species are assigned inheritable predation efficiencies during their creation, leading to evolutionary dynamics and thus population-level optimization. We derive an effective subspecies mean-field theory and compare its results to our numerical data. Furthermore, we introduce environmental variability via quenched spatial reaction-rate randomness. We investigate the competing effects and relative importance of the two types of variability, and find that both lead to a remarkable enhancement of the species densities, while the aforementioned optimization effects are essentially neutral in the densities. Additionally, we collected extinction time histograms for small systems and find a marked increase in the stability of the populations against extinction due to the presence of variability. We employ an elastic line model to investigate the steady-state properties and non-equilibrium relaxation kinetics of magnetic vortex lines in disordered type-II superconductors. To this end, we developed a versatile and efficient Langevin molecular dynamics simulation code, allowing us to do a careful study of samples with or without vortex-vortex interactions or disorder allows us to disentangle the various complex relaxational features present in this system and investigate their origin. In particular, we compare disordered samples with randomly distributed point defects versus correlated columnar defects. We extract two-time quantities such as the mean-square displacement, the height and density correlations, to investigate the

  7. The catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts.

    Science.gov (United States)

    Vidale, Pamela; Magnani, Elisa; Nergadze, Solomon G; Santagostino, Marco; Cristofari, Gael; Smirnova, Alexandra; Mondello, Chiara; Giulotto, Elena

    2012-10-01

    Many human primary somatic cells can be immortalized by inducing telomerase activity through the exogenous expression of the human telomerase catalytic subunit (hTERT). This approach has been extended to the immortalization of cell lines from several mammals. Here, we show that hTERT expression is not sufficient to immortalize primary fibroblasts from three equid species, namely donkey, Burchelli's zebra and Grevy's zebra. In vitro analysis of a reconstituted telomerase composed by hTERT and an equid RNA component of telomerase (TERC) revealed a low activity of this enzyme compared to human telomerase, suggesting a low compatibility of equid and human telomerase subunits. This conclusion was also strengthened by comparison of human and equid TERC sequences, which revealed nucleotide differences in key regions for TERC and TERT interaction. We then succeeded in immortalizing equid fibroblasts by expressing hTERT and hTERC concomitantly. Expression of both human telomerase subunits led to telomerase activity and telomere elongation, indicating that human telomerase is compatible with the other equid telomerase subunits and proteins involved in telomere metabolism. The immortalization procedure described herein could be extended to primary cells from other mammals. The availability of immortal cells from endangered species could be particularly useful for obtaining new information on the organization and function of their genomes, which is relevant for their preservation.

  8. Shadows of the susceptible-infectious-susceptible immortality transition in small networks

    Science.gov (United States)

    Holme, Petter

    2015-07-01

    Much of the research on the behavior of the SIS model on networks has concerned the infinite size limit; in particular the phase transition between a state where outbreaks can reach a finite fraction of the population, and a state where only a finite number would be infected. For finite networks, there is also a dynamic transition—the immortality transition—when the per-contact transmission probability λ reaches 1. If λ <1 , the probability that an outbreak will survive by an observation time t tends to zero as t →∞ ; if λ =1 , this probability is 1. We show that treating λ =1 as a critical point predicts the λ dependence of the survival probability also for more moderate λ values. The exponent, however, depends on the underlying network. This fact could, by measuring how a vertex's deletion changes the exponent, be used to evaluate the role of a vertex in the outbreak. Our work also confirms an extremely clear separation between the early die-off (from the outbreak failing to take hold in the population) and the later extinctions (corresponding to rare stochastic events of several consecutive transmission events failing to occur).

  9. Predictability of threshold exceedances in dynamical systems

    Science.gov (United States)

    Bódai, Tamás

    2015-12-01

    In a low-order model of the general circulation of the atmosphere we examine the predictability of threshold exceedance events of certain observables. The likelihood of such binary events-the cornerstone also for the categoric (as opposed to probabilistic) prediction of threshold exceedances-is established from long time series of one or more observables of the same system. The prediction skill is measured by a summary index of the ROC curve that relates the hit- and false alarm rates. Our results for the examined systems suggest that exceedances of higher thresholds are more predictable; or in other words: rare large magnitude, i.e., extreme, events are more predictable than frequent typical events. We find this to hold provided that the bin size for binning time series data is optimized, but not necessarily otherwise. This can be viewed as a confirmation of a counterintuitive (and seemingly contrafactual) statement that was previously formulated for more simple autoregressive stochastic processes. However, we argue that for dynamical systems in general it may be typical only, but not universally true. We argue that when there is a sufficient amount of data depending on the precision of observation, the skill of a class of data-driven categoric predictions of threshold exceedances approximates the skill of the analogous model-driven prediction, assuming strictly no model errors. Therefore, stronger extremes in terms of higher threshold levels are more predictable both in case of data- and model-driven prediction. Furthermore, we show that a quantity commonly regarded as a measure of predictability, the finite-time maximal Lyapunov exponent, does not correspond directly to the ROC-based measure of prediction skill when they are viewed as functions of the prediction lead time and the threshold level. This points to the fact that even if the Lyapunov exponent as an intrinsic property of the system, measuring the instability of trajectories, determines predictability

  10. Organic Carbon Dynamics in Glacier Systems

    Science.gov (United States)

    Barker, J.; Sharp, M.; Klassen, J.; Foght, J.; Turner, R.

    2004-12-01

    The biogeochemical cycling of organic carbon (OC) has important implications for aquatic system ecology because the abundance and molecular characteristics of OC influence contaminant transport and bioavailability, and determine its suitability as a substrate for microbial metabolism. There have been few studies of OC cycling in glacier systems, and questions remain regarding the abundance, provenance, and biogeochemical transformations of OC in these environments. To address these questions, the abundance and molecular characteristics of OC is investigated in three glacier systems. These systems are characterized by different thermal and hydrological regimes and have different potential OC sources. John Evans Glacier is a polythermal glacier in arctic Canada. Outre Glacier is a temperate glacier in the Coast Mountains of British Columbia, Canada. Victoria Upper Glacier is a cold-based glacier in the McMurdo Dry Valleys of Antarctica. To provide an indication of the extent to which glacier system OC dynamics are microbially mediated, microbial culturing and identification is performed and organic acid abundance and speciation is determined. Where possible, samples of supraglacial runoff, glacier ice and basal ice and subglacial meltwater were collected. The dissolved organic carbon (DOC) concentration in each sample was measured by combustion/non-dispersive infrared gas analysis. Emission and synchronous fluorescence spectroscopy were used to characterize the molecular properties of the DOC from each environment. When possible, microbial culturing and identification was performed and organic acid identification and quantification was measured by ion chromatography. DOC exists in detectable quantities (0.06-46.6 ppm) in all of the glacier systems that were investigated. The molecular characteristics of DOC vary between glaciers, between environments at the same glacier, and over time within a single environment. Viable microbes are recoverable in significant (ca

  11. The Quest for Immortality: Science at the Frontiers of Aging

    Energy Technology Data Exchange (ETDEWEB)

    Olshansky, S. Jay (University of Illinois at Chicago); Carnes, Bruce A. (University of Chicago)

    2001-10-24

    For more than a decade, Dr. Olshansky and Dr. Carnes have been working in the field of aging to identify the biological attributes of species that influence their length of life. Amid countless claims by scientists and the lay population that human life expectancy will continue to rise indefinitely in the future, Olshansky and Carnes have stood fast in their conviction that such claims are without any scientific basis. In their book The Quest for Immortality, S. Jay Olshansky and Bruce A. Carnes provide a comprehensive account of the real science of aging, from a historical overview of religious and philosophical thinking about aging and death, to the biology behind the changes we see in the mirror, to the promising but frightening future of genetic engineering. They demystify the complex language and concepts of science, explain how to distinguish real science from media hype in order to help readers make informed health decisions, and offer a powerfully optimistic vision of aging and health in the twenty-first century.

  12. The singularity of being: Lacan and the immortal within.

    Science.gov (United States)

    Ruti, Mari

    2010-12-01

    Drawing on the work of Eric Santner, Slavoj Žižek, and Alenka Zupančič, this paper constructs a theory of subjective singularity from a Lacanian perspective. It argues that, unlike the "subject" (who comes into existence as a result of symbolic prohibition), or the "person" (who is aligned with the narcissistic conceits of the imaginary), the singular self emerges in response to a galvanizing directive arising from the real. This directive summons the individual to a "character" beyond his or her social and intersubjective investments. Consequently, singularity expresses the individual's nonnegotiable distinctiveness, eccentricity, or idiosyncrasy at the same time as it prevents both symbolic and imaginary closure. It opens to layers of rebelliousness that indicate that there are components of human life that exceed the realm of normative sociality. Indeed, insofar as singularity articulates something about the "undead" pulse of jouissance, it connects the individual to a paradoxical kind of immortality. This does not mean that the individual will not die, but rather that he or she is capable of "transcendent" experiences, such as heightened states of creativity, that (always momentarily) reach "outside" the parameters of mortal life. Such experiences allow the individual to feel "real" in ways that fend off symbolic abduction and psychic death.

  13. DYSCO: A software system for modeling general dynamic systems

    Science.gov (United States)

    Berman, Alex

    1989-01-01

    The DYSCO program has been under development since 1979. It has been funded by Army and Air Force laboratories and by the Kaman Aerospace Corporation. It is presently available at a number of government and nongovernment installations. It has been used to analyze a very broad range of dynamics problems. A principle feature of the software design of DYSCO is the separation of the executive from the technology. The executive, which controls all the operations, is intelligent in the sense that it knows that its function is to assemble differential equations and to prepare them for solution. The technology library contains FORTRAN routines which perform standard functions, such as, computing the equation coefficients of an element (or component) given the local state at any time. The technology library also contains algorithms and procedures for solving the coupled system equations. The system was designed to allow easy additional of technology to the library. Any linear or nonlinear structural entity, control system, or set of ordinary differential equations may be simply coded and added to the library, as well as algorithms for time or frequency domain solution. The program is described with emphasis on its usefulness in easily modeling unusual concepts and configurations, performing analysis of damage, evaluating new algorithms, and simulating dynamic tests.

  14. Rapid dynamical chaos in an exoplanetary system

    CERN Document Server

    Deck, Katherine M; Agol, Eric; Carter, Joshua A; Lissauer, Jack J; Ragozzine, Darin; Winn, Joshua N

    2012-01-01

    We report on the long-term dynamical evolution of the two-planet Kepler-36 system, which we studied through numerical integrations of initial conditions that are consistent with observations of the system. The orbits are chaotic with a Lyapunov time of only ~10 years. The chaos is a consequence of a particular set of orbital resonances, with the inner planet orbiting 34 times for every 29 orbits of the outer planet. The rapidity of the chaos is due to the interaction of the 29:34 resonance with the nearby first order 6:7 resonance, in contrast to the usual case in which secular terms in the Hamiltonian play a dominant role. Only one contiguous region of phase space, accounting for ~4.5% of the sample of initial conditions studied, corresponds to planetary orbits that do not show large scale orbital instabilities on the timescale of our integrations (~200 million years). The long-lived subset of the allowed initial conditions are those that satisfy the Hill stability criterion by the largest margin. Any succes...

  15. Hybrid modeling and prediction of dynamical systems

    Science.gov (United States)

    Lloyd, Alun L.; Flores, Kevin B.

    2017-01-01

    Scientific analysis often relies on the ability to make accurate predictions of a system’s dynamics. Mechanistic models, parameterized by a number of unknown parameters, are often used for this purpose. Accurate estimation of the model state and parameters prior to prediction is necessary, but may be complicated by issues such as noisy data and uncertainty in parameters and initial conditions. At the other end of the spectrum exist nonparametric methods, which rely solely on data to build their predictions. While these nonparametric methods do not require a model of the system, their performance is strongly influenced by the amount and noisiness of the data. In this article, we consider a hybrid approach to modeling and prediction which merges recent advancements in nonparametric analysis with standard parametric methods. The general idea is to replace a subset of a mechanistic model’s equations with their corresponding nonparametric representations, resulting in a hybrid modeling and prediction scheme. Overall, we find that this hybrid approach allows for more robust parameter estimation and improved short-term prediction in situations where there is a large uncertainty in model parameters. We demonstrate these advantages in the classical Lorenz-63 chaotic system and in networks of Hindmarsh-Rose neurons before application to experimentally collected structured population data. PMID:28692642

  16. Dynamics and Control of a Class of Underactuated Mechanical Systems

    OpenAIRE

    Reyhanoglu, Mahmut; van der Schaft, Arjan; McClamroch, N. Harris; Kolmanovsky, Ilya

    1999-01-01

    This paper presents a theoretical framework for the dynamics and control of underactuated mechanical systems, defined as systems with fewer inputs than degrees of freedom. Control system formulation of underactuated mechanical systems is addressed and a class of underactuated systems characterized by nonintegrable dynamics relations is identified. Controllability and stabilizability results are derived for this class of underactuated systems. Examples are included to illustrate the results; t...

  17. Reversible immortalization of Nestin-positive precursor cells from pancreas and differentiation into insulin-secreting cells

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Pei; Li, Li; Qi, Hui [The Clinical Medical Research Center, The Second Clinical Medical College (Shenzhen People' s Hospital), Jinan University, 518020 Shenzhen (China); Zhou, Han-xin [Department of General Surgery, First Hospital (Shenzhen Second People' s Hospital) of Shenzhen University, 518020 Shenzhen (China); Deng, Chun-yan [The Clinical Medical Research Center, The Second Clinical Medical College (Shenzhen People' s Hospital), Jinan University, 518020 Shenzhen (China); Li, Fu-rong, E-mail: frli62@yahoo.com [The Clinical Medical Research Center, The Second Clinical Medical College (Shenzhen People' s Hospital), Jinan University, 518020 Shenzhen (China); Shenzhen Institution of Gerontology, 518020 Shenzhen (China)

    2012-02-10

    Highlights: Black-Right-Pointing-Pointer The NPPCs from mouse pancreas were isolated. Black-Right-Pointing-Pointer Tet-on system for SV40 large in NPPCs was used to get RINPPCs. Black-Right-Pointing-Pointer The RINPPCs can undergo at least 80 population doublings without senescence. Black-Right-Pointing-Pointer The RINPPCs can be induced to differentiate into insulin-producing cells. Black-Right-Pointing-Pointer The combination of GLP-1 and sodium butyrate promoted the differentiation process. -- Abstract: Pancreatic stem cells or progenitor cells posses the ability of directed differentiation into pancreatic {beta} cells. However, these cells usually have limited proliferative capacity and finite lifespan in vitro. In the present study, Nestin-positive progenitor cells (NPPCs) from mouse pancreas that expressed the pancreatic stem cells or progenitor cell marker Nestin were isolated to obtain a sufficient number of differentiated pancreatic {beta} cells. Tet-on system for SV40 large T-antigen expression in NPPCs was used to achieve reversible immortalization. The reversible immortal Nestin-positive progenitor cells (RINPPCs) can undergo at least 80 population doublings without senescence in vitro while maintaining their biological and genetic characteristics. RINPPCs can be efficiently induced to differentiate into insulin-producing cells that contain a combination of glucagon-like peptide-1 (GLP-1) and sodium butyrate. The results of the present study can be used to explore transplantation therapy of type I diabetes mellitus.

  18. Nonlinear dynamics analysis of a new autonomous chaotic system

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, a new nonlinear autonomous system introduced by Chlouverakis and Sprott is studied further, to present very rich and complex nonlinear dynamical behaviors. Some basic dynamical properties are studied either analytically or nuchaotic system with very high Lyapunov dimensions is constructed and investigated. Two new nonlinear autonomous systems can be changed into one another by adding or omitting some constant coefficients.

  19. A Formal Framework for P Systems with Dynamic Structure

    OpenAIRE

    Freund, Rudolf; Pérez Hurtado de Mendoza, Ignacio; Riscos Núñez, Agustín; Verlan, Sergey

    2012-01-01

    This article introduces a formalism/framework able to describe different variants of P systems having a dynamic structure. This framework can be useful for the definition of new variants of P systems with dynamic structure, for the comparison of existing definitions as well as for their extension. We give a precise definition of the formalism and show how existing variants of P systems with dynamic structure can be translated to it.

  20. Entropy of Fuzzy Partitions and Entropy of Fuzzy Dynamical Systems

    Directory of Open Access Journals (Sweden)

    Dagmar Markechová

    2016-01-01

    Full Text Available In the paper we define three kinds of entropy of a fuzzy dynamical system using different entropies of fuzzy partitions. It is shown that different definitions of the entropy of fuzzy partitions lead to different notions of entropies of fuzzy dynamical systems. The relationships between these entropies are studied and connections with the classical case are mentioned as well. Finally, an analogy of the Kolmogorov–Sinai Theorem on generators is proved for fuzzy dynamical systems.