WorldWideScience

Sample records for dynamic product assembly

  1. Dynamics of assembly production flow

    Science.gov (United States)

    Ezaki, Takahiro; Yanagisawa, Daichi; Nishinari, Katsuhiro

    2015-06-01

    Despite recent developments in management theory, maintaining a manufacturing schedule remains difficult because of production delays and fluctuations in demand and supply of materials. The response of manufacturing systems to such disruptions to dynamic behavior has been rarely studied. To capture these responses, we investigate a process that models the assembly of parts into end products. The complete assembly process is represented by a directed tree, where the smallest parts are injected at leaves and the end products are removed at the root. A discrete assembly process, represented by a node on the network, integrates parts, which are then sent to the next downstream node as a single part. The model exhibits some intriguing phenomena, including overstock cascade, phase transition in terms of demand and supply fluctuations, nonmonotonic distribution of stockout in the network, and the formation of a stockout path and stockout chains. Surprisingly, these rich phenomena result from only the nature of distributed assembly processes. From a physical perspective, these phenomena provide insight into delay dynamics and inventory distributions in large-scale manufacturing systems.

  2. Dynamic behaviour of diagnostic assemblies

    International Nuclear Information System (INIS)

    Pecinka, L.

    1980-01-01

    The methodology is shown of calculating the frequency spectrum of a diagnostic assembly. The oscillations of the assembly as a whole, of a fuel rod bundle, the assembly jacket and of the individual rods in the bundle were considered. The manufacture is suggested of a model assembly which would be used for testing forced vibrations using an experimental water loop. (M.S.)

  3. Virtual Reality and Haptics for Product Assembly

    Directory of Open Access Journals (Sweden)

    Maria Teresa Restivo

    2012-01-01

    Full Text Available Haptics can significantly enhance the user's sense of immersion and interactivity. An industrial application of virtual reality and haptics for product assembly is described in this paper, which provides a new and low-cost approach for product assembly design, assembly task planning and assembly operation training. A demonstration of the system with haptics device interaction was available at the session of exp.at'11.

  4. Assembly and method for drying a product

    NARCIS (Netherlands)

    Boxtel, van A.J.B.; Bartels, P.V.; Djaeni, M.; Sanders, J.P.M.; Straten, van G.

    2008-01-01

    The application relates to an assembly for drying a product, comprising at least on drying device and at least one adsorption device, in which the adsorption device is provided with regenerable adsorption material for extracting water from a gas and comprises a gas inlet and a gas outlet, and is

  5. Math on the Job. Metal Product Assembler.

    Science.gov (United States)

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    This booklet is intended to help mainstreamed mentally retarded, emotionally disturbed, or learning disabled high school students acquire a basic understanding of the responsibilities and working conditions of metal product assemblers and to practice basic math skills necessary in the occupation. The first section provides a brief introduction to…

  6. Dynamics of magnetic nano-particle assembly

    International Nuclear Information System (INIS)

    Kondratyev, V N

    2010-01-01

    Ferromagnetically coupled nano-particle assembly is analyzed accounting for inter- and intra- particle electronic structures within the randomly jumping interacting moments model including quantum fluctuations due to the discrete levels and disorder. At the magnetic jump anomalies caused by quantization the magnetic state equation and phase diagram are found to indicate an existence of spinodal regions and critical points. Arrays of magnetized nano-particles with multiple magnetic response anomalies are predicted to display some specific features. In a case of weak coupling such arrays exhibit the well-separated instability regions surrounding the anomaly positions. With increasing coupling we observe further structure modification, plausibly, of bifurcation type. At strong coupling the dynamical instability region become wide while the stable regime arises as a narrow islands at small disorders. It is shown that exploring correlations of magnetic noise amplitudes represents convenient analytical tool for quantitative definition, description and study of supermagnetism, as well as self-organized criticality.

  7. An assembly of tritium production experiment

    International Nuclear Information System (INIS)

    Abe, Toshihiko

    1981-01-01

    An assembly for tritium production experiment, i.e. Tritium Extraction System (TREX) constructed as a small scale test facility for tritium production, and Tritium Removal System (TRS) attached to TREX, and the preliminary results of the experiments with them are described. The radiological safety of the process and operation is also an important consideration. Lithium-aluminum alloy was selected as the most promising target material. The following matters are involved in the scope of production technology: the selection of a target material and target preparation, reactor irradiation, the construction of a facility for the extraction of tritium from the irradiated target, the establishment of the optimum conditions of extraction, the purification, collection and storage of tritium, and the inspection of the product. The tritium production experiment at JAERI is yet on the initial stage; the development is to be continued with the stepwise increase of the scale of tritium production. (J.P.N.)

  8. Modular Product Families and Assembly Systems

    DEFF Research Database (Denmark)

    Thyssen, Jesper

    2005-01-01

    This research centres on assembly systems designed for utilizing product modularization. Altogether, the task for companies has become an issue of managing the overall trade-off between the external market’s desire for variety and the internal efficiency and effectiveness. Product modularization...... a number of theoretical and managerial implications are identified. From a management point of view, the most im-portant finding is that modularization needs to be configured for the two competitive situations, i.e. 1) the volume flexible configuration focusing on generational product variety and 2......) the mix flexible con-figuration focusing on the simultaneous product variety. These two views are in particular different in respect to the understanding of product modularization. All in all, modularization needs to be, and can be, configured in regard to the specific task, which is believed constituting...

  9. Dynamic Multi-Component Hemiaminal Assembly

    Science.gov (United States)

    You, Lei; Long, S. Reid; Lynch, Vincent M.

    2012-01-01

    A simple approach to generating in situ metal templated tris-(2-picolyl)amine-like multi-component assemblies with potential applications in molecular recognition and sensing is reported. The assembly is based on the reversible covalent association between di-(2-picolyl)amine and aldehydes. Zinc ion is the best for inducing assembly among the metal salts investigated, while 2-picolinaldehyde is the best among the heterocyclic aldehydes studied. Although an equilibrium constant of 6.6 * 103 M-1 was measured for the assembly formed by 2-picolinaldehdye, di-(2-picolyl)amine, and zinc triflate, the equilibrium constants for other systems are in the 102 M-1 range. X-ray structural analysis revealed that zinc adopts a trigonal bipyramidal geometry within the assembled ligand. The diversity and equilibrium of the assemblies are readily altered by simply changing concentrations, varying components, or adding counter anions. PMID:21919095

  10. Dynamic multiprotein assemblies shape the spatial structure of cell signaling.

    Science.gov (United States)

    Nussinov, Ruth; Jang, Hyunbum

    2014-01-01

    Cell signaling underlies critical cellular decisions. Coordination, efficiency as well as fail-safe mechanisms are key elements. How the cell ensures that these hallmarks are at play are important questions. Cell signaling is often viewed as taking place through discrete and cross-talking pathways; oftentimes these are modularized to emphasize distinct functions. While simple, convenient and clear, such models largely neglect the spatial structure of cell signaling; they also convey inter-modular (or inter-protein) spatial separation that may not exist. Here our thesis is that cell signaling is shaped by a network of multiprotein assemblies. While pre-organized, the assemblies and network are loose and dynamic. They contain transiently-associated multiprotein complexes which are often mediated by scaffolding proteins. They are also typically anchored in the membrane, and their continuum may span the cell. IQGAP1 scaffolding protein which binds proteins including Raf, calmodulin, Mek, Erk, actin, and tens more, with actin shaping B-cell (and likely other) membrane-anchored nanoclusters and allosterically polymerizing in dynamic cytoskeleton formation, and Raf anchoring in the membrane along with Ras, provides a striking example. The multivalent network of dynamic proteins and lipids, with specific interactions forming and breaking, can be viewed as endowing gel-like properties. Collectively, this reasons that efficient, productive and reliable cell signaling takes place primarily through transient, preorganized and cooperative protein-protein interactions spanning the cell rather than stochastic, diffusion-controlled processes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Dynamical analysis of critical assembly CC-1

    International Nuclear Information System (INIS)

    Aleman Fernandez, J.R.

    1990-01-01

    The computer code CC-1, elaborated for the analysis of transients in Critical Assemblies is described. The results by the program are compared with the ones presented in the Safety Report for the Critical Assembly of ''La Quebrada'' Nuclear Research Centre (CIN). 7 refs

  12. Harnessing natural product assembly lines: structure, promiscuity, and engineering.

    Science.gov (United States)

    Ladner, Christopher C; Williams, Gavin J

    2016-03-01

    Many therapeutically relevant natural products are biosynthesized by the action of giant mega-enzyme assembly lines. By leveraging the specificity, promiscuity, and modularity of assembly lines, a variety of strategies has been developed that enables the biosynthesis of modified natural products. This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and non-ribosomal peptide analogues.

  13. Hierarchical silica particles by dynamic multicomponent assembly

    DEFF Research Database (Denmark)

    Wu, Z. W.; Hu, Q. Y.; Pang, J. B.

    2005-01-01

    Abstract: Aerosol-assisted assembly of mesoporous silica particles with hierarchically controllable pore structure has been prepared using cetyltrimethylammonium bromide (CTAB) and poly(propylene oxide) (PPO, H[OCH(CH3)CH2],OH) as co-templates. Addition of the hydrophobic PPO significantly...... influences the delicate hydrophilic-hydrophobic balance in the well-studied CTAB-silicate co-assembling system, resulting in various mesostructures (such as hexagonal, lamellar, and hierarchical structure). The co-assembly of CTAB, silicate clusters, and a low-molecular-weight PPO (average M-n 425) results...... in a uniform lamellar structure, while the use of a high-molecular-weight PPO (average M-n 2000), which is more hydrophobic, leads to the formation of hierarchical pore structure that contains meso-meso or meso-macro pore structure. The role of PPO additives on the mesostructure evolution in the CTAB...

  14. Spatio-temporal Dynamics and Mechanisms of Stress Granule Assembly.

    Directory of Open Access Journals (Sweden)

    Daisuke Ohshima

    2015-06-01

    Full Text Available Stress granules (SGs are non-membranous cytoplasmic aggregates of mRNAs and related proteins, assembled in response to environmental stresses such as heat shock, hypoxia, endoplasmic reticulum (ER stress, chemicals (e.g. arsenite, and viral infections. SGs are hypothesized as a loci of mRNA triage and/or maintenance of proper translation capacity ratio to the pool of mRNAs. In brain ischemia, hippocampal CA3 neurons, which are resilient to ischemia, assemble SGs. In contrast, CA1 neurons, which are vulnerable to ischemia, do not assemble SGs. These results suggest a critical role SG plays in regards to cell fate decisions. Thus SG assembly along with its dynamics should determine the cell fate. However, the process that exactly determines the SG assembly dynamics is largely unknown. In this paper, analyses of experimental data and computer simulations were used to approach this problem. SGs were assembled as a result of applying arsenite to HeLa cells. The number of SGs increased after a short latent period, reached a maximum, then decreased during the application of arsenite. At the same time, the size of SGs grew larger and became localized at the perinuclear region. A minimal mathematical model was constructed, and stochastic simulations were run to test the modeling. Since SGs are discrete entities as there are only several tens of them in a cell, commonly used deterministic simulations could not be employed. The stochastic simulations replicated observed dynamics of SG assembly. In addition, these stochastic simulations predicted a gamma distribution relative to the size of SGs. This same distribution was also found in our experimental data suggesting the existence of multiple fusion steps in the SG assembly. Furthermore, we found that the initial steps in the SG assembly process and microtubules were critical to the dynamics. Thus our experiments and stochastic simulations presented a possible mechanism regulating SG assembly.

  15. Dynamics of self-assembled cytosine nucleobases on graphene

    Science.gov (United States)

    Saikia, Nabanita; Johnson, Floyd; Waters, Kevin; Pandey, Ravindra

    2018-05-01

    Molecular self-assembly of cytosine (C n ) bases on graphene was investigated using molecular dynamics methods. For free-standing C n bases, simulation conditions (gas versus aqueous) determine the nature of self-assembly; the bases prefer to aggregate in the gas phase and are stabilized by intermolecular H-bonds, while in the aqueous phase, the water molecules disrupt base-base interactions, which facilitate the formation of π-stacked domains. The substrate-induced effects, on the other hand, find the polarity and donor-acceptor sites of the bases to govern the assembly process. For example, in the gas phase, the assembly of C n bases on graphene displays short-range ordered linear arrays stabilized by the intermolecular H-bonds. In the aqueous phase, however, there are two distinct configurations for the C n bases assembly on graphene. For the first case corresponding to low surface coverage, the bases are dispersed on graphene and are isolated. The second configuration archetype is disordered linear arrays assembled with medium and high surface coverage. The simulation results establish the role of H-bonding, vdW π-stacking, and the influence of graphene surface towards the self-assembly. The ability to regulate the assembly into well-defined patterns can aid in the design of self-assembled nanostructures for the next-generation DNA based biosensors and nanoelectronic devices.

  16. Uncertainty propagation through dynamic models of assemblies of mechanical structures

    International Nuclear Information System (INIS)

    Daouk, Sami

    2016-01-01

    When studying the behaviour of mechanical systems, mathematical models and structural parameters are usually considered deterministic. Return on experience shows however that these elements are uncertain in most cases, due to natural variability or lack of knowledge. Therefore, quantifying the quality and reliability of the numerical model of an industrial assembly remains a major question in low-frequency dynamics. The purpose of this thesis is to improve the vibratory design of bolted assemblies through setting up a dynamic connector model that takes account of different types and sources of uncertainty on stiffness parameters, in a simple, efficient and exploitable in industrial context. This work has been carried out in the framework of the SICODYN project, led by EDF R and D, that aims to characterise and quantify, numerically and experimentally, the uncertainties in the dynamic behaviour of bolted industrial assemblies. Comparative studies of several numerical methods of uncertainty propagation demonstrate the advantage of using the Lack-Of-Knowledge theory. An experimental characterisation of uncertainties in bolted structures is performed on a dynamic test rig and on an industrial assembly. The propagation of many small and large uncertainties through different dynamic models of mechanical assemblies leads to the assessment of the efficiency of the Lack-Of-Knowledge theory and its applicability in an industrial environment. (author)

  17. The Model of Temperature Dynamics of Pulsed Fuel Assembly

    CERN Document Server

    Bondarchenko, E A; Popov, A K

    2002-01-01

    Heat exchange process differential equations are considered for a subcritical fuel assembly with an injector. The equations are obtained by means of the use of the Hermit polynomial. The model is created for modelling of temperature transitional processes. The parameters and dynamics are estimated for hypothetical fuel assembly consisting of real mountings: the powerful proton accelerator and the reactor IBR-2 core at its subcritica l state.

  18. Simulation model of dynamical behaviour of reactor fuel assemblies

    International Nuclear Information System (INIS)

    Planchard, J.

    1994-01-01

    This report briefly describes the homogenized dynamical equations of a tube bundle placed in a perfect irrotational fluid, on case of small displacements. This approach can be used to study the mechanical behaviour of fuel assemblies of PWR reactor submitted to earthquake or depressurization blow-down. The numerical calculations require to define the added mass matrix of the fuel assemblies, for which the principle of computation is presented. (author). 14 refs., 4 figs

  19. Classification of assembly techniques for micro products

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Tosello, Guido; Gegeckaite, Asta

    2005-01-01

    of components and level of integration are made. This paper describes a systematic characterization of micro assembly methods. This methodology offers the opportunity of a cross comparison among different techniques to gain a choosing principle of the favourable micro assembly technology in a specific case...

  20. Self-assembling, dynamic alphaPNAs

    DEFF Research Database (Denmark)

    Nielsen, Peter E

    2009-01-01

    In the recent report published in Science, Ghadiri and coworkers describe dynamic tPNAs, alphaPNA derivatives with a nucleobase attached via a thioester bond that are a step forward toward self-repairing and replicating molecules.......In the recent report published in Science, Ghadiri and coworkers describe dynamic tPNAs, alphaPNA derivatives with a nucleobase attached via a thioester bond that are a step forward toward self-repairing and replicating molecules....

  1. Optimal production planning for PCB assembly

    CERN Document Server

    Ho, William

    2006-01-01

    Focuses on the optimization of the Printed circuit board (PCB) assembly lines' efficiency. This book integrates the component sequencing and the feeder arrangement problems together for the pick-and-place machine and the chip shooter machines.

  2. Dynamics of nuclear fuel assemblies in vertical flow channels

    International Nuclear Information System (INIS)

    Mason, V.A.

    1988-01-01

    DYNMOD is a computer program designed to predict the dynamic behaviour of nuclear fuel assemblies in axial flow. The calculations performed by DYNMOD and the input data required by the program are described in this report. Examples of DYNMOD usage and a brief assessment of the accuracy of the dynamic model are also presented. It is intended that the report will be used as a reference manual by users of DYNMOD

  3. Driving dynamic colloidal assembly using eccentric self-propelled colloids

    OpenAIRE

    Ma, Zhan; Lei, Qun-li; Ni, Ran

    2017-01-01

    Designing protocols to dynamically direct the self-assembly of colloidal particles has become an important direction in soft matter physics because of the promising applications in fabrication of dynamic responsive functional materials. Here using computer simulations, we found that in the mixture of passive colloids and eccentric self-propelled active particles, when the eccentricity and self-propulsion of active particles are high enough, the eccentric active particles can push passive coll...

  4. Dynamic response of a typical synchrotron magnet/girder assembly

    International Nuclear Information System (INIS)

    Jendrzejczyk, J.A.; Smith, R.K.; Vogt, M.E.

    1993-06-01

    In the Advanced Photon Source, the synchrotron booster ring accelerates positrons to the required energy level of 7 GeV. The positrons are then injected into the storage ring where they continue to orbit for 10--15 h. The storage ring quadrupoles have very stringent vibration criteria that must be satisfied to ensure that beam emittance growth is within acceptable limits, viz., <10%. Because the synchrotron booster ring is not operated after particle insertion into the storage ring, its vibration response is not a critical issue relative to the performance of the storage ring beam. Nevertheless, the synchrotron pulses at a frequency of 2 Hz, and if a vibration response frequency of the synchrotron magnet/girder assembly were to coincide with the pulsation frequency or its near harmonics, large-amplitude motion could result, with the effect that it could compromise the operation of the synchrotron. Due to the complex dynamics of the synchrotron magnet/girder assembly, it is necessary to measure the dynamic response of a prototypic assembly and its components to ensure that the inherent dynamic response frequencies are not equal to 2 Hz or any near harmonics. Dynamic-response measurement of the synchrotron girder assembly and component magnets is the subject of this report

  5. Studying protein assembly with reversible Brownian dynamics of patchy particles

    International Nuclear Information System (INIS)

    Klein, Heinrich C. R.; Schwarz, Ulrich S.

    2014-01-01

    Assembly of protein complexes like virus shells, the centriole, the nuclear pore complex, or the actin cytoskeleton is strongly determined by their spatial structure. Moreover, it is becoming increasingly clear that the reversible nature of protein assembly is also an essential element for their biological function. Here we introduce a computational approach for the Brownian dynamics of patchy particles with anisotropic assemblies and fully reversible reactions. Different particles stochastically associate and dissociate with microscopic reaction rates depending on their relative spatial positions. The translational and rotational diffusive properties of all protein complexes are evaluated on-the-fly. Because we focus on reversible assembly, we introduce a scheme which ensures detailed balance for patchy particles. We then show how the macroscopic rates follow from the microscopic ones. As an instructive example, we study the assembly of a pentameric ring structure, for which we find excellent agreement between simulation results and a macroscopic kinetic description without any adjustable parameters. This demonstrates that our approach correctly accounts for both the diffusive and reactive processes involved in protein assembly

  6. Studying protein assembly with reversible Brownian dynamics of patchy particles

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Heinrich C. R. [Institute for Theoretical Physics, Heidelberg University, 69120 Heidelberg (Germany); Schwarz, Ulrich S., E-mail: ulrich.schwarz@bioquant.uni-heidelberg.de [Institute for Theoretical Physics, Heidelberg University, 69120 Heidelberg (Germany); BioQuant, Heidelberg University, 69120 Heidelberg (Germany)

    2014-05-14

    Assembly of protein complexes like virus shells, the centriole, the nuclear pore complex, or the actin cytoskeleton is strongly determined by their spatial structure. Moreover, it is becoming increasingly clear that the reversible nature of protein assembly is also an essential element for their biological function. Here we introduce a computational approach for the Brownian dynamics of patchy particles with anisotropic assemblies and fully reversible reactions. Different particles stochastically associate and dissociate with microscopic reaction rates depending on their relative spatial positions. The translational and rotational diffusive properties of all protein complexes are evaluated on-the-fly. Because we focus on reversible assembly, we introduce a scheme which ensures detailed balance for patchy particles. We then show how the macroscopic rates follow from the microscopic ones. As an instructive example, we study the assembly of a pentameric ring structure, for which we find excellent agreement between simulation results and a macroscopic kinetic description without any adjustable parameters. This demonstrates that our approach correctly accounts for both the diffusive and reactive processes involved in protein assembly.

  7. Combinatorial Models for Assembly and Decomposition of Products

    OpenAIRE

    A. N. Bojko

    2015-01-01

    The paper discusses the most popular combinatorial models that are used for the synthesis of design solutions at the stage of the assembly process flow preparation. It shows that while assembling the product the relations of parts can be represented as a structure of preferences, which is formed on the basis of objective design restrictions put in at the stage of the product design. This structure is a binary preference relation pre-order. Its symmetrical part is equivalence and describes the...

  8. Dynamic simulations of many-body electrostatic self-assembly

    Science.gov (United States)

    Lindgren, Eric B.; Stamm, Benjamin; Maday, Yvon; Besley, Elena; Stace, A. J.

    2018-03-01

    Two experimental studies relating to electrostatic self-assembly have been the subject of dynamic computer simulations, where the consequences of changing the charge and the dielectric constant of the materials concerned have been explored. One series of calculations relates to experiments on the assembly of polymer particles that have been subjected to tribocharging and the simulations successfully reproduce many of the observed patterns of behaviour. A second study explores events observed following collisions between single particles and small clusters composed of charged particles derived from a metal oxide composite. As before, observations recorded during the course of the experiments are reproduced by the calculations. One study in particular reveals how particle polarizability can influence the assembly process. This article is part of the theme issue `Modern theoretical chemistry'.

  9. Investigation of transient dynamics of capillary assisted particle assembly yield

    Energy Technology Data Exchange (ETDEWEB)

    Virganavičius, D. [Institute of Materials Science, Kaunas University of Technology, K. Baršausko St. 59, Kaunas LT-51423 (Lithuania); Laboratory of Micro- and Nanotechnology, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Juodėnas, M. [Institute of Materials Science, Kaunas University of Technology, K. Baršausko St. 59, Kaunas LT-51423 (Lithuania); Tamulevičius, T., E-mail: tomas.tamulevicius@ktu.lt [Institute of Materials Science, Kaunas University of Technology, K. Baršausko St. 59, Kaunas LT-51423 (Lithuania); Department of Physics, Kaunas University of Technology, Studentų St. 50, Kaunas LT-51368 (Lithuania); Schift, H. [Laboratory of Micro- and Nanotechnology, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Tamulevičius, S. [Institute of Materials Science, Kaunas University of Technology, K. Baršausko St. 59, Kaunas LT-51423 (Lithuania); Department of Physics, Kaunas University of Technology, Studentų St. 50, Kaunas LT-51368 (Lithuania)

    2017-06-01

    Highlights: • Regular particles arrays were assembled by capillary force assisted deposition. • Deposition yield dynamics was investigated at different thermal velocity regimes. • Yield transient behavior was approximated with logistic function. • Pattern density influence for switching behavior was assessed. - Abstract: In this paper, the transient behavior of the particle assembly yield dynamics when switching from low yield to high yield deposition at different velocity and thermal regimes is investigated. Capillary force assisted particle assembly (CAPA) using colloidal suspension of green fluorescent 270 nm diameter polystyrene beads was performed on patterned poly (dimethyl siloxane) substrates using a custom-built deposition setup. Two types of patterns with different trapping site densities were used to assess CAPA process dynamics and the influence of pattern density and geometry on the deposition yield transitions. Closely packed 300 nm diameter circular pits ordered in hexagonal arrangement with 300 nm pitch, and 2 × 2 mm{sup 2} square pits with 2 μm spacing were used. 2-D regular structures of the deposited particles were investigated by means of optical fluorescence and scanning electron microscopy. The fluorescence micrographs were analyzed using a custom algorithm enabling to identify particles and calculate efficiency of the deposition performed at different regimes. Relationship between the spatial distribution of particles in transition zone and ambient conditions was evaluated and quantified by approximation of the yield profile with a logistic function.

  10. Combinatorial Models for Assembly and Decomposition of Products

    Directory of Open Access Journals (Sweden)

    A. N. Bojko

    2015-01-01

    Full Text Available The paper discusses the most popular combinatorial models that are used for the synthesis of design solutions at the stage of the assembly process flow preparation. It shows that while assembling the product the relations of parts can be represented as a structure of preferences, which is formed on the basis of objective design restrictions put in at the stage of the product design. This structure is a binary preference relation pre-order. Its symmetrical part is equivalence and describes the entry of parts into the assembly unit. The asymmetric part is a partial order. It specifies part- ordering time in in the course of the assembly process. The structure of preferences is a minimal description of the restrictions and constraints in the assembly process. It can serve as a source for generating multiple assembly sequences of a product and its components, which are allowed by design. This multiplicity increases the likelihood of rational choice under uncertainty, unpredictable changes in the properties of technological or industrial systems.Incomplete dominance relation gives grounds for further examination and better understanding of the project situation. Operation field of the study is limited to a set of disparate elements of the partial order. Different strategies for processing the disparate elements may be offered, e.g. selection of the most informative pairs, comparison of which foremost linearizes the original partial order.

  11. Mudular Product Families and Assembly Systems

    DEFF Research Database (Denmark)

    Thyssen, Jesper

    of theoretical and managerial implications are identified. From a management point of view, the most important finding is that modularization needs to be configured for two competitive situations, i.e. the volume flexible configuration focusing on generational product variety and the mix flexible configuration...... focusing on the simultaneous product variety. These two views are in particular different as to the understanding of product modularization. All in all, modularization needs to be, and can be, configured with regard to the specific task, which is believed constituting one important contribution......  The main objective of this thesis is to investigate the phenomenon of product modularization as an apparently both powerful and complex means. The focal research objective is to obtain an improved insight and understanding of the relationship between variables associated with configuration...

  12. Managing lifelike behavior in a dynamic self-assembled system

    Science.gov (United States)

    Ropp, Chad; Bachelard, Nicolas; Wang, Yuan; Zhang, Xiang

    Self-organization can arise outside of thermodynamic equilibrium in a process of dynamic self-assembly. This is observed in nature, for example in flocking birds, but can also be created artificially with non-living entities. Such dynamic systems often display lifelike properties, including the ability to self-heal and adapt to environmental changes, which arise due to the collective and often complex interactions between the many individual elements. Such interactions are inherently difficult to predict and control, and limit the development of artificial systems. Here, we report a fundamentally new method to manage dynamic self-assembly through the direct external control of collective phenomena. Our system consists of a waveguide filled with mobile scattering particles. These particles spontaneously self-organize when driven by a coherent field, self-heal when mechanically perturbed, and adapt to changes in the drive wavelength. This behavior is governed by particle interactions that are completely mediated by coherent wave scattering. Compared to hydrodynamic interactions which lead to compact ordered structures, our system displays sinusoidal degeneracy and many different steady-state geometries that can be adjusted using the external field.

  13. Dynamic colloidal assembly pathways via low dimensional models

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Yuguang; Bevan, Michael A., E-mail: mabevan@jhu.edu [Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Thyagarajan, Raghuram; Ford, David M. [Chemical Engineering, University of Massachusetts, Amherst, Massachusetts 01003 (United States)

    2016-05-28

    Here we construct a low-dimensional Smoluchowski model for electric field mediated colloidal crystallization using Brownian dynamic simulations, which were previously matched to experiments. Diffusion mapping is used to infer dimensionality and confirm the use of two order parameters, one for degree of condensation and one for global crystallinity. Free energy and diffusivity landscapes are obtained as the coefficients of a low-dimensional Smoluchowski equation to capture the thermodynamics and kinetics of microstructure evolution. The resulting low-dimensional model quantitatively captures the dynamics of different assembly pathways between fluid, polycrystal, and single crystals states, in agreement with the full N-dimensional data as characterized by first passage time distributions. Numerical solution of the low-dimensional Smoluchowski equation reveals statistical properties of the dynamic evolution of states vs. applied field amplitude and system size. The low-dimensional Smoluchowski equation and associated landscapes calculated here can serve as models for predictive control of electric field mediated assembly of colloidal ensembles into two-dimensional crystalline objects.

  14. Dynamic covalent gels assembled from small molecules:from discrete gelators to dynamic covalent polymers

    Institute of Scientific and Technical Information of China (English)

    Jian-Yong Zhang; Li-Hua Zeng; Juan Feng

    2017-01-01

    Dynamic covalent chemistry has emerged recently to be a powerful tool to construct functional materials.This article reviews the progress in the research and development of dynamic covalent chemistry in gels assembled from small molecules.First dynamic covalent reactions used in gels are reviewed to understand the dynamic covalent bonding.Afterwards the catalogues of dynamic covalent gels are reviewed according to the nature of gelators and the interactions between gelators.Dynamic covalent bonding can be involved to form low molecular weight gelators.Low molecular weight molecules with multiple functional groups react to form dynamic covalent cross-linked polymers and act as gelators.Two catalogues of gels show different properties arising from their different structures.This review aims to illustrate the structure-property relationships of these dynamic covalent gels.

  15. Bucket Brigades to Increase Productivity in a Luxury Assembly Line

    OpenAIRE

    Carlo, Filippo De; Borgia, Orlando; Tucci, Mario

    2013-01-01

    One of the most challenging issues in manual assembly lines is to achieve the best balance of workloads. There are many analytic approaches to solve this problem, but they are often neglected, since they are time-consuming and require high level engineering skills. Fashion bags packaging lines must comply with a number of different products with low production volumes, while the organization of the line is often under the mere responsibility of the foreman, who balances workloads in an empiri...

  16. Dynamic characterization of satellite assembly for responsive space applications

    International Nuclear Information System (INIS)

    Mascarenas, David; Macknelly, David; Mullins, Josh; Wiest, Heather; Park, Gyuhae

    2013-01-01

    The rapid deployment of satellites for responsive space surveillance applications is hindered by the need to flight-qualify their components and the resulting mechanical assembly. Conventional methods for qualification testing of satellite components are costly and time consuming. Furthermore, full-scale vehicles must be subjected to simulated launch loads during testing, and this harsh testing environment increases the risk of damage to satellite components during qualification. This work focuses on replacing this potentially destructive testing procedure with a non-destructive structural health monitoring (SHM)-based technique while maintaining the same level of confidence in the testing procedure's ability to qualify the satellite for flight. We focus on assessing the performance of SHM techniques to replace the high-cost qualification procedure and to localize faults introduced by improper assembly. The goal of this work is to create a dual-use system that can both assist in the process of qualifying the satellite for launch, as well as provide continuous structural integrity monitoring during manufacture, transport, launch and deployment. SHM techniques were applied on a small-scale structure representative of a responsive satellite. The test structure consisted of an extruded aluminum space-frame covered with aluminum shear plates assembled using bolted joints. Multiple piezoelectric transducers were bonded to the test structure and acted as combined actuators and sensors. Piezoelectric active-sensing based techniques, including measurements of low-frequency global frequency response functions and high-frequency wave propagation techniques, were employed. Using these methods in conjunction with finite element modeling, the dynamic properties of the test structure were established and areas of potential damage could be identified and localized. A procedure for guiding the effective placement of the sensors and actuators is also outlined. (paper)

  17. Molecular Dynamics Simulation of Salt Diffusion in Polyelectrolyte Assemblies.

    Science.gov (United States)

    Zhang, Ran; Duan, Xiaozheng; Ding, Mingming; Shi, Tongfei

    2018-06-05

    The diffusion of salt ions and charged probe molecules in polyelectrolyte assemblies is often assumed to follow a theoretical hopping model, in which the diffusing ion is hopping between charged sites of chains based on electroneutrality. However, experimental verification of diffusing pathway at such microscales is difficult, and the corresponding molecular mechanisms remain elusive. In this study, we perform all-atom molecular dynamics (MD) simulations of salt diffusion in polyelectrolyte (PE) assembly of poly (sodium 4-styrenesulfonate) (PSS) and poly (diallyldimethylammonium chloride) (PDAC). Besides the ion hopping mode, the diffusing trajectories are found presenting common features of a jump process, i.e., subjecting to PE relaxation, water pockets in the structure open and close, thus the ion can move from one pocket to another. Anomalous subdiffusion of ions and water is observed due to the trapping scenarios in these water pockets. The jump events are much rarer compared with ion hopping but significantly increases salt diffusion with increasing temperature. Our result strongly indicates that salt diffusion in hydrated PDAC/PSS is a combined process of ion hopping and jump motion. This provides new molecular explanation for the coupling of salt motion with chain motion and the nonlinear increase of salt diffusion at glass transition temperature.

  18. Vegetation Dynamics and Community Assembly in Post-Agricultural Heathland

    DEFF Research Database (Denmark)

    Kepfer Rojas, Sebastian

    that land-use legacies are still present in the soil and were important determinants of vegetation dynamics and community assembly. However, the effects of land-use legacies were mostly mediated by the understory vegetation and differed according to the functional groups. The distance to the edge, a proxy...... for the proximity to external seed sources, was an important factor affecting different components of the structure of the vegetation, demonstrating the importance of dispersal in the development of the community. My results indicate that the effect of the biotic interactions varies along abiotic gradients (e......Summary This PhD study aims at understanding how biotic, abiotic and stochastic factors interact to structure a heathland vegetation community managed under different traditional land-use practices for centuries prior to abandonment ca. 120 years ago. This study is part of one of the longest...

  19. Dynamic and bio-orthogonal protein assembly along a supramolecular polymer

    NARCIS (Netherlands)

    Petkau - Milroy, K.; Uhlenheuer, D.A.; Spiering, A.J.H.; Vekemans, J.A.J.M.; Brunsveld, L.

    2013-01-01

    Dynamic protein assembly along supramolecular columnar polymers has been achieved through the site-specific covalent attachment of different SNAP-tag fusion proteins to self-assembled benzylguanine-decorated discotics. The self-assembly of monovalent discotics into supramolecular polymers creates a

  20. Vectorization and parallelization of a production reactor assembly code

    International Nuclear Information System (INIS)

    Vujic, J.L.; Martin, W.R.; Michigan Univ., Ann Arbor, MI

    1991-01-01

    In order to use efficiently the new features of supercomputers, production codes, usually written 10 -20 years ago, must be tailored for modern computer architectures. We have chosen to optimize the CPM-2 code, a production reactor assembly code based on the collision probability transport method. Substantial speedup in the execution times was obtained with the parallel/vector version of the CPM-2 code. In addition, we have developed a new transfer probability method, which removes some of the modelling limitations of the collision probability method encoded in the CPM-2 code, and can fully utilize the parallel/vector architecture of a multiprocessor IBM 3090. (author)

  1. Vectorization and parallelization of a production reactor assembly code

    International Nuclear Information System (INIS)

    Vujic, J.L.; Martin, W.R.

    1991-01-01

    In order to efficiently use new features of supercomputers, production codes, usually written 10 - 20 years ago, must be tailored for modern computer architectures. We have chosen to optimize the CPM-2 code, a production reactor assembly code based on the collision probability transport method. Substantial speedups in the execution times were obtained with the parallel/vector version of the CPM-2 code. In addition, we have developed a new transfer probability method, which removes some of the modelling limitations of the collision probability method encoded in the CPM-2 code, and can fully utilize parallel/vector architecture of a multiprocessor IBM 3090. (author)

  2. Thermal Hydraulic Computational Fluid Dynamics Simulations and Experimental Investigation of Deformed Fuel Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Mays, Brian [AREVA Federal Services, Lynchburg, VA (United States); Jackson, R. Brian [TerraPower, Bellevue, WA (United States)

    2017-03-08

    The project, Toward a Longer Life Core: Thermal Hydraulic CFD Simulations and Experimental Investigation of Deformed Fuel Assemblies, DOE Project code DE-NE0008321, was a verification and validation project for flow and heat transfer through wire wrapped simulated liquid metal fuel assemblies that included both experiments and computational fluid dynamics simulations of those experiments. This project was a two year collaboration between AREVA, TerraPower, Argonne National Laboratory and Texas A&M University. Experiments were performed by AREVA and Texas A&M University. Numerical simulations of these experiments were performed by TerraPower and Argonne National Lab. Project management was performed by AREVA Federal Services. The first of a kind project resulted in the production of both local point temperature measurements and local flow mixing experiment data paired with numerical simulation benchmarking of the experiments. The project experiments included the largest wire-wrapped pin assembly Mass Index of Refraction (MIR) experiment in the world, the first known wire-wrapped assembly experiment with deformed duct geometries and the largest numerical simulations ever produced for wire-wrapped bundles.

  3. Bucket Brigades to Increase Productivity in a Luxury Assembly Line

    Directory of Open Access Journals (Sweden)

    Filippo De Carlo

    2013-08-01

    Full Text Available One of the most challenging issues in manual assembly lines is to achieve the best balance of workloads. There are many analytic approaches to solve this problem, but they are often neglected, since they are time-consuming and require high level engineering skills. Fashion bags packaging lines must comply with a number of different products with low production volumes, while the organization of the line is often under the mere responsibility of the foreman, who balances workloads in an empirical way. The aim of this work is to evaluate the effectiveness of the arrangement of bucket brigades (BBs for an assembly line of luxury handbags. To do this, it was decided to perform a testing activity in a company producing fashion handbags in order to compare the self-made design with the BBs and with a simple assembly line balancing problem algorithm. The originality of this research lies in the fact that there are no studies in the literature on BBs applied to the packaging of highly variable small batches. The results were excellent, showing the advantages of BBs in terms of flexibility, the reduction of work in the process and the ability to handle small anomalies.

  4. Conformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies.

    Science.gov (United States)

    Kim, Do-Nyun; Altschuler, Josiah; Strong, Campbell; McGill, Gaël; Bathe, Mark

    2011-01-01

    The conformational dynamics data bank (CDDB, http://www.cdyn.org) is a database that aims to provide comprehensive results on the conformational dynamics of high molecular weight proteins and protein assemblies. Analysis is performed using a recently introduced coarse-grained computational approach that is applied to the majority of structures present in the electron microscopy data bank (EMDB). Results include equilibrium thermal fluctuations and elastic strain energy distributions that identify rigid versus flexible protein domains generally, as well as those associated with specific functional transitions, and correlations in molecular motions that identify molecular regions that are highly coupled dynamically, with implications for allosteric mechanisms. A practical web-based search interface enables users to easily collect conformational dynamics data in various formats. The data bank is maintained and updated automatically to include conformational dynamics results for new structural entries as they become available in the EMDB. The CDDB complements static structural information to facilitate the investigation and interpretation of the biological function of proteins and protein assemblies essential to cell function.

  5. Interface between the production plan and the master production schedule in assembly environments

    OpenAIRE

    Moya Navarro, Marcos; Sánchez Brenes, Magaly

    2012-01-01

    In a production environment there is a direct relationship between the market and the manufacturing process of goods.When production is immersed in an assembly environment, the process of production planning and scheduling becomes complex, and the enterprises have the risk of losing competitive advantages in terms of not meeting delivery dates and production high costs. Linear programming has become an appropriate tool for production planning and scheduling in complex manufacturing environmen...

  6. Seismic analysis of fuel and target assemblies at a production reactor

    International Nuclear Information System (INIS)

    Braverman, J.I.; Wang, Y.K.

    1991-01-01

    This paper describes the unique modeling and analysis considerations used to assess the seismic adequacy of the fuel and target assemblies in a production reactor at Savannah River Site. This confirmatory analysis was necessary to provide assurance that the reactor can operate safely during a seismic event and be brought to a safe shutdown condition. The plant which was originally designed in the 1950's required to be assessed to more current seismic criteria. The design of the reactor internals and the magnitude of the structural responses enabled the use of a linear elastic dynamic analysis. A seismic analysis was performed using a finite element model consisting of the fuel and target assemblies, reactor tank, and a portion of the concrete structure supporting the reactor tank. The effects of submergence of the fuel and target assemblies in the water contained within the reactor tank can have a significant effect on their seismic response. Thus, the model included hydrodynamic fluid coupling effects between the assemblies and the reactor tank. Fluid coupling mass terms were based on formulations for solid bodies immersed in incompressible and frictionless fluids. The potential effects of gap conditions were also assessed in this evaluation. 5 refs., 6 figs., 1 tab

  7. Dynamic transformation of self-assembled structures using anisotropic magnetized hydrogel microparticles

    Science.gov (United States)

    Yoshida, Satoru; Takinoue, Masahiro; Iwase, Eiji; Onoe, Hiroaki

    2016-08-01

    This paper describes a system through which the self-assembly of anisotropic hydrogel microparticles is achieved, which also enables dynamic transformation of the assembled structures. Using a centrifuge-based microfluidic device, anisotropic hydrogel microparticles encapsulating superparamagnetic materials on one side are fabricated, which respond to a magnetic field. We successfully achieve dynamic assembly using these hydrogel microparticles and realize three different self-assembled structures (single and double pearl chain structures, and close-packed structures), which can be transformed to other structures dynamically via tuning of the precessional magnetic field. We believe that the developed system has potential application as an effective platform for a dynamic cell manipulation and cultivation system, in biomimetic autonomous microrobot organization, and that it can facilitate further understanding of the self-organization and complex systems observed in nature.

  8. Further development of the Dynamic Control Assemblies Worth Measurement Method for Advanced Reactivity Computers

    International Nuclear Information System (INIS)

    Petenyi, V.; Strmensky, C.; Jagrik, J.; Minarcin, M.; Sarvaic, I.

    2005-01-01

    The dynamic control assemblies worth measurement technique is a quick method for validation of predicted control assemblies worth. The dynamic control assemblies worth measurement utilize space-time corrections for the measured out of core ionization chamber readings calculated by DYN 3D computer code. The space-time correction arising from the prompt neutron density redistribution in the measured ionization chamber reading can be directly applied in the advanced reactivity computer. The second correction concerning the difference of spatial distribution of delayed neutrons can be calculated by simulation the measurement procedure by dynamic version of the DYN 3D code. In the paper some results of dynamic control assemblies worth measurement applied for NPP Mochovce are presented (Authors)

  9. Measurement and analysis on dynamic behaviour of parallel-plate assembly in nuclear reactors

    International Nuclear Information System (INIS)

    Chen Junjie; Guo Changqing; Zou Changchuan

    1997-01-01

    Measurement and analysis on dynamic behaviour of parallel-plate assembly in nuclear reactors have been explored. The electromagnetic method, a new method of measuring and analysing dynamic behaviour with the parallel-plate assembly as the structure of multi-parallel-beams joining with single-beam, has been presented. Theoretical analysis and computation results of dry-modal natural frequencies show good agreement with experimental measurements

  10. Visit to the Russian Production and Assembly Sites in March 2000 (photos obtained from MPI)

    CERN Multimedia

    2000-01-01

    Photo1 - EST electrode production at LPI. Photo2 - EST electrode production at LPI. Photo3 - EST electrode production at LPI. Photo4 - Cold test of EST electrodes at LPI. Photo5 - Cold test of EST electrodes at LPI. Photo6 - The device for cleaning honeycomb mats at JINR. Photo7 - Module assembly at IHEP. Photo8 - Module assembly at IHEP. Photo9 - Module assembly at IHEP. Photo10 - Transport cases for "Molniya" modules (former bomb cases)

  11. Dynamic analytical and experimental research of shock absorber to safeguard the nuclear fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Dundulis, Gintautas, E-mail: gintas@mail.lei.lt [Laboratory of Nuclear Installation Safety, Lithuanian Energy Institute, Breslaujos str. 3, LT-44403 Kaunas (Lithuania); Grybenas, Albertas [Laboratory of Materials Research and Testing, Lithuanian Energy Institute, Breslaujos str. 3, LT-44403 Kaunas (Lithuania); Karalevicius, Renatas [Laboratory of Nuclear Installation Safety, Lithuanian Energy Institute, Breslaujos str. 3, LT-44403 Kaunas (Lithuania); Makarevicius, Vidas [Laboratory of Materials Research and Testing, Lithuanian Energy Institute, Breslaujos str. 3, LT-44403 Kaunas (Lithuania); Rimkevicius, Sigitas; Uspuras, Eugenijus [Laboratory of Nuclear Installation Safety, Lithuanian Energy Institute, Breslaujos str. 3, LT-44403 Kaunas (Lithuania)

    2013-07-15

    Highlights: • Plastical deformation of the shock absorber. • Dynamic testing of the scaled shock absorber. • Dynamic simulation of the shock absorber using finite element method. • Strain-rate evaluation in dynamic analysis. • Variation of displacement, acceleration and velocity during dynamic impact. -- Abstract: The Ignalina Nuclear Power Plant (NPP) has two RBMK-1500 graphite moderated boiling water multi-channel reactors. The Ignalina NPP Unit 1 was shut down at the end of 2004 while Unit 2 has been in operation for over 5 years. After shutdown at the Unit 1 remained spent fuel assemblies with low burn-up depth. In order to reuse these assemblies in the reactor of Unit 2 a special set of equipment was developed. One of the most important items of this set is a container, which is used for the transportation of spent fuel assemblies between the reactors of Unit 1 and Unit 2. A special shock absorber was designed to avoid failure of fuel assemblies in case of hypothetical spent fuel assemblies drop accident during uploading/unloading of spent fuel assemblies to/from container. This shock absorber was examined using scaled experiments and finite element analysis. Static and dynamic investigations of the shock absorber were performed for the estimation and optimization of its geometrical parameters. The objective of this work is the estimation whether the proposed design of shock absorber can fulfil the stopping function of the spent fuel assemblies and is capable to withstand the dynamics load. Experimental testing of scaled shock absorber models and dynamic analytical investigations using the finite element code ABAQUS/Explicit were performed. The simulation model was verified by comparing the experimental and simulation results and it was concluded that the shock absorber is capable to withstand the dynamic load, i.e. successful force suppression function in case of accident.

  12. Group dynamics in the Citizens' Assembly on Electoral Reform

    NARCIS (Netherlands)

    Jongh, M.S. de

    2013-01-01

    In 2006, the Dutch Ministry of the Interior and Kingdom Relations set up a national citizen assembly on electoral reform. One hundred and forty Dutch citizens were asked to work together for nine months to investigate various electoral systems for choosing members of the Parliament, and eventually

  13. Approach to Dynamic Assembling of Individualized Learning Paths

    Science.gov (United States)

    Lubchak, Vladimir; Kupenko, Olena; Kuzikov, Borys

    2012-01-01

    E-learning students are generally heterogeneous and have different capabilities knowledge base and needs. The aim of the Sumy State University (SSU) e-learning system project is to cater to these individual needs by assembling individual learning path. This paper shows current situation with e-learning in Ukraine, state-of-art of development of…

  14. Reactor Dynamics Experiments with a Sub-Critical Assembly

    International Nuclear Information System (INIS)

    Miley, G.H.; Yang, Y.; Wu, L.; Momota, H.

    2004-01-01

    A resurgence in use of nuclear power is now underway worldwide. However due to the shutdown of many university research reactors , student laboratories must rely more heavily on use of sub-critical assemblies. Here a driven sub-critical is described that uses a cylindrical Inertial Electrostatic Confinement (IEC) device to provide a fusion neutron source. The small IEC neutron source would be inserted in a fuel element position, with its power input controlled externally at a control panel. This feature opens the way to use of the critical assembly for a number of transient experiments such as sub-critical pulsing and neutron wave propagation. That in turn adds important new insights and excitement for the student teaching laboratory

  15. Microtubule dynamics. II. Kinetics of self-assembly

    DEFF Research Database (Denmark)

    Flyvbjerg, H.; Jobs, E.

    1997-01-01

    Inverse scattering theory describes the conditions necessary and sufficient to determine an unknown potential from known scattering data. No similar theory exists for when and how one may deduce the kinetics of an unknown chemical reaction from quantitative information about its final state and i...... to analyze the self-assembly of microtubules from tubulin are general, and many other reactions and processes may be studied as inverse problems with these methods when enough experimental data are available....

  16. Market Dynamics and Productivity in Developing Countries ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    25 nov. 2009 ... Market Dynamics and Productivity in Developing Countries : Economic Reforms in the Middle East and North Africa. Book cover Market Dynamics and Productivity in Developing Countries: Economic Reforms in the Middle East. Directeur(s):. Khalid Sekkat. Maison(s) d'édition: Springer, CDRI. 25 novembre ...

  17. A participatory and integrative approach to increase productivity and comfort in assembly

    NARCIS (Netherlands)

    Looze, M.P. de; Rhijn, G. van; Tuinzaad, B.; Deursen, J. van

    2000-01-01

    Manufacturers of manually assembled products are more and more forced to improve the flow of assembly orders together with a more efficient employment, in order to meet increasing demands on short delivery times, high product variety, good quality and low manufacturing costs. At the same time, the

  18. "Cloud" assemblies: quantum dots form electrostatically bound dynamic nebulae around large gold nanoparticles.

    Science.gov (United States)

    Lilly, G Daniel; Lee, Jaebeom; Kotov, Nicholas A

    2010-10-14

    Dynamic self-assembled structures of nanoparticles can be produced using predominantly electrostatic interactions. Such assemblies were made from large, positively charged Au metal nanoparticles surrounded by an electrostatically bound cloud of smaller, negatively charged CdSe/ZnS or CdTe quantum dots. At low concentrations they are topologically similar to double electric layers of ions and corona-like assemblies linked by polymer chains. They can also be compared to the topological arrangement of some planetary systems in space. The great advantages of the cloud assemblies are (1) their highly dynamic nature compared to more rigid covalently bound assemblies, (2) simplicity of preparation, and (3) exceptional versatility in components and resulting optical properties. Photoluminescence intensity enhancement originating from quantum resonance between excitons and plasmons was observed for CdSe/ZnS quantum dots, although CdTe dots displayed emission quenching. To evaluate more attentively their dynamic behavior, emission data were collected for the cloud-assemblies with different ratios of the components and ionic strengths of the media. The emission of the system passes through a maximum for 80 QDs ∶ 1 Au NP as determined by the structure of the assemblies and light absorption conditions. Ionic strength dependence of luminescence intensity contradicts the predictions based on the Gouy-Chapman theory and osmotic pressure at high ionic strengths due to formation of larger chaotic colloidally stable assemblies. "Cloud" assemblies made from different nanoscale components can be used both for elucidation of most fundamental aspects of nanoparticle interactions, as well as for practical purposes in sensing and biology.

  19. Protein dynamics during presynaptic complex assembly on individual ssDNA molecules

    OpenAIRE

    Gibb, Bryan; Ye, Ling F.; Kwon, YoungHo; Niu, Hengyao; Sung, Patrick; Greene, Eric C.

    2014-01-01

    Homologous recombination is a conserved pathway for repairing double?stranded breaks, which are processed to yield single?stranded DNA overhangs that serve as platforms for presynaptic complex assembly. Here we use single?molecule imaging to reveal the interplay between Saccharomyce cerevisiae RPA, Rad52, and Rad51 during presynaptic complex assembly. We show that Rad52 binds RPA?ssDNA and suppresses RPA turnover, highlighting an unanticipated regulatory influence on protein dynamics. Rad51 b...

  20. Dynamic protein assembly by programmable DNA strand displacement

    Science.gov (United States)

    Chen, Rebecca P.; Blackstock, Daniel; Sun, Qing; Chen, Wilfred

    2018-03-01

    Inspired by the remarkable ability of natural protein switches to sense and respond to a wide range of environmental queues, here we report a strategy to engineer synthetic protein switches by using DNA strand displacement to dynamically organize proteins with highly diverse and complex logic gate architectures. We show that DNA strand displacement can be used to dynamically control the spatial proximity and the corresponding fluorescence resonance energy transfer between two fluorescent proteins. Performing Boolean logic operations enabled the explicit control of protein proximity using multi-input, reversible and amplification architectures. We further demonstrate the power of this technology beyond sensing by achieving dynamic control of an enzyme cascade. Finally, we establish the utility of the approach as a synthetic computing platform that drives the dynamic reconstitution of a split enzyme for targeted prodrug activation based on the sensing of cancer-specific miRNAs.

  1. THE DYNAMIC RESPONSE OF THERMOMETER-WELL ASSEMBLIES.

    Science.gov (United States)

    parameter models of the thermometric system were constructed and gave acceptable agreement with the experimental results. These models can be used to predict the dynamic behavior of any similar thermometer system. (Author)

  2. Unbalance influence on the rotating assembly dynamics of a hydro

    Science.gov (United States)

    Jurcu, M.; Pădureanu, I.; Campian, C. V.; Haţiegan, C.

    2018-01-01

    The dynamics of the rotating parts of a hydro is characterized by the dynamic interaction between the rotor, the stator and the working fluid in order to operate the hydro. The main factors influencing the dynamics of the rotating parts of a hydro are: rotor unbalance, unbalanced magnetic pull, shaft misalignment and hydraulic flow regime. Rotor unbalanced is one of the most common factors influencing the dynamic stability of the rotating parts of a hydro. The unbalanced is determined by: uneven distribution of rotating masses, displacement of parts in the rotor during rotation, inhomogeneity of rotor component materials, expansion of the rotor due to heating, and rising speed during the transient discharge of the load. The mechanical imbalance of a rotor can lead to important forces, responsible for the vibration of the machine, which ultimately leads to a shorter operating time. Even a low unbalance can lead, in the case of high speed machines, to major unbalance forces that cause significant damage to the equipment. The unbalance forces cause additional vibrations in the bearings as well as in the foundation plate. To avoid these vibrations, it is necessary in the first stage to balance the static rotor in the construction plant and then to a dynamic rotation balancing.

  3. Dynamics of nuclear fuel assemblies in vertical flow channels: computer modelling and associated studies

    International Nuclear Information System (INIS)

    Mason, V.A.; Pettigrew, M.J.; Lelli, G.; Kates, L.; Reimer, E.

    1978-10-01

    A computer model, designed to predict the dynamic behaviour of nuclear fuel assemblies in axial flow, is described in this report. The numerical methods used to construct and solve the matrix equations of motion in the model are discussed together with an outline of the method used to interpret the fuel assembly stability data. The mathematics developed for forced response calculations are described in detail. Certain structural and hydrodynamic modelling parameters must be determined by experiment. These parameters are identified and the methods used for their evaluation are briefly described. Examples of typical applications of the dynamic model are presented towards the end of the report. (author)

  4. Primal and dual dynamic Luenberger productivity indicators

    NARCIS (Netherlands)

    Oude Lansink, A.G.J.M.; Stefanou, S.E.; Serra, T.

    2015-01-01

    This paper develops primal and dual versions of the dynamic Luenberger productivity growth measures that are based on the dynamic directional distance function and intertemporal cost minimization, respectively. The empirical application focuses on panel data of Dutch dairy farms over the period

  5. Nonconsumable electrode assembly and use thereof for the electrolytic production of metals and silicon

    Science.gov (United States)

    Byrne, Stephen C.; Ray, Siba P.

    1984-01-01

    A nonconsumable electrode assembly suitable for use in the production of metal by electrolytic reduction of a metal compound dissolved in a molten salt, the assembly comprising a metal conductor attached to a ceramic electrode body by a metal bond on a portion of the body having a level of free metal or metal alloy sufficient to effect a metal bond.

  6. Diffusion welded nonconsumable electrode assembly and use thereof for electrolytic production of metals and silicon

    Science.gov (United States)

    Byrne, Stephen C.; Vasudevan, Asuri K.

    1984-01-01

    A nonconsumable electrode assembly suitable for use in the production of metal by electrolytic reduction of a metal compound dissolved in a molten salt, the assembly comprising a metal conductor diffusion welded to a portion of a ceramic electrode body having a level of free metal or metal alloy sufficient to effect a metal bond.

  7.  The Assembly of Lean Production: An Analysis of Doing Production Improvements

    OpenAIRE

    Andersson, Gunnar

    2011-01-01

    This thesis is an analysis of the assembly of the zero-defects project at Glomma Papp AS, a company on manufacture of paper, corrugated board, solid board and display, in Sarpsborg Norway. The zero-defects project was a local production improvement project based on approaches, tools and methods known as Lean. The project is seen as an actor-network, which means that its reality, and the understandings and practices of it, are effects of the web of people, structures, technologies and others w...

  8. Supramolecular assembly/reassembly processes: molecular motors and dynamers operating at surfaces.

    Science.gov (United States)

    Ciesielski, Artur; Samorì, Paolo

    2011-04-01

    Among the many significant advances within the field of supramolecular chemistry over the past decades, the development of the so-called "dynamers" features a direct relevance to materials science. Defined as "combinatorial dynamic polymers", dynamers are constitutional dynamic systems and materials resulting from the application of the principles of supramolecular chemistry to polymer science. Like supramolecular materials in general, dynamers are reversible dynamic multifunctional architectures, capable of modifying their constitution by exchanging, recombining, incorporating components. They may exhibit a variety of novel properties and behave as adaptive materials. In this review we focus on the design of responsive switchable monolayers, i.e. monolayers capable to undergo significant changes in their physical or chemical properties as a result of external stimuli. Scanning tunneling microscopy studies provide direct evidence with a sub-nanometre resolution, on the formation and dynamic response of these self-assembled systems featuring controlled geometries and properties.

  9. Large-scale molecular dynamics simulations of self-assembling systems.

    Science.gov (United States)

    Klein, Michael L; Shinoda, Wataru

    2008-08-08

    Relentless increases in the size and performance of multiprocessor computers, coupled with new algorithms and methods, have led to novel applications of simulations across chemistry. This Perspective focuses on the use of classical molecular dynamics and so-called coarse-grain models to explore phenomena involving self-assembly in complex fluids and biological systems.

  10. DNA Self-Assembly and Computation Studied with a Coarse-grained Dynamic Bonded Model

    DEFF Research Database (Denmark)

    Svaneborg, Carsten; Fellermann, Harold; Rasmussen, Steen

    2012-01-01

    We utilize a coarse-grained directional dynamic bonding DNA model [C. Svaneborg, Comp. Phys. Comm. (In Press DOI:10.1016/j.cpc.2012.03.005)] to study DNA self-assembly and DNA computation. In our DNA model, a single nucleotide is represented by a single interaction site, and complementary sites can...

  11. Dynamics of decanethiol self-assembled monolayers on Au(111) studied by Scanning tunnelling microscopy

    NARCIS (Netherlands)

    Wu, Hairong; Sotthewes, Kai; Kumar, Avijit; Vancso, Gyula J.; Schön, Peter Manfred; Zandvliet, Henricus J.W.

    2013-01-01

    We investigated the dynamics of decanethiol self-assembled monolayers on Au(111) surfaces using time-resolved scanning tunneling microscopy at room temperature. The expected ordered phases (β, δ, χ*, and ) and a disordered phase (ε) were observed. Current–time traces with the feedback loop disabled

  12. Due date assignment procedures with dynamically updated coefficients for multi-level assembly job shops

    NARCIS (Netherlands)

    Adam, N.R.; Bertrand, J.W.M.; Morehead, D.C.; Surkis, J.

    1993-01-01

    This paper presents a study of due date assignment procedures in job shop environments where multi-level assembly jobs are processed and due dates are internally assigned. Most of the reported studies in the literature have focused on string type jobs. We propose a dynamic update approach (which

  13. Investigation of transient dynamics of capillary assisted particle assembly yield

    DEFF Research Database (Denmark)

    Tamulevičius, S.; Virganavičius, D.; Juodėnas, M.

    2017-01-01

    diameter polystyrene beads was performed on patterned poly (dimethyl siloxane) substrates using a custom-built deposition setup. Two types of patterns with different trapping site densities were used to assess CAPA process dynamics and the influence of pattern density and geometry on the deposition yield....... The fluorescence micrographs were analyzed using a custom algorithm enabling to identify particles and calculate efficiency of the deposition performed at different regimes. Relationship between the spatial distribution of particles in transition zone and ambient conditions was evaluated and quantified...... by approximation of the yield profile with a logistic function....

  14. Dynamics of nanoparticle self-assembly into superhydrophobic liquid marbles during water condensation.

    Science.gov (United States)

    Rykaczewski, Konrad; Chinn, Jeff; Walker, Marlon L; Scott, John Henry J; Chinn, Amy; Jones, Wanda

    2011-12-27

    Nanoparticles adsorbed onto the surface of a drop can fully encapsulate the liquid, creating a robust and durable soft solid with superhydrophobic characteristics referred to as a liquid marble. Artificially created liquid marbles have been studied for about a decade but are already utilized in some hair and skin care products and have numerous other potential applications. These soft solids are usually formed in small quantity by depositing and rolling a drop of liquid on a layer of hydrophobic particles but can also be made in larger quantities in an industrial mixer. In this work, we demonstrate that microscale liquid marbles can also form through self-assembly during water condensation on a superhydrophobic surface covered with a loose layer of hydrophobic nanoparticles. Using in situ environmental scanning electron microscopy and optical microscopy, we study the dynamics of liquid marble formation and evaporation as well as their interaction with condensing water droplets. We demonstrate that the self-assembly of nanoparticle films into three-dimensional liquid marbles is driven by multiple coalescence events between partially covered droplets and is aided by surface flows causing rapid nanoparticle film redistribution. We also show that droplet and liquid marble coalescence can occur due to liquid-to-liquid contact or squeezing of the two objects into each other as a result of compressive forces from surrounding droplets and marbles. Irrelevant of the mechanism, coalescence of marbles and drops can cause their rapid movement across and rolling off the edge of the surface. We also demonstrate that the liquid marbles randomly moving across the surface can be captured and immobilized by hydrophilic surface patterns.

  15. A computational investigation on the connection between dynamics properties of ribosomal proteins and ribosome assembly.

    Directory of Open Access Journals (Sweden)

    Brittany Burton

    Full Text Available Assembly of the ribosome from its protein and RNA constituents has been studied extensively over the past 50 years, and experimental evidence suggests that prokaryotic ribosomal proteins undergo conformational changes during assembly. However, to date, no studies have attempted to elucidate these conformational changes. The present work utilizes computational methods to analyze protein dynamics and to investigate the linkage between dynamics and binding of these proteins during the assembly of the ribosome. Ribosomal proteins are known to be positively charged and we find the percentage of positive residues in r-proteins to be about twice that of the average protein: Lys+Arg is 18.7% for E. coli and 21.2% for T. thermophilus. Also, positive residues constitute a large proportion of RNA contacting residues: 39% for E. coli and 46% for T. thermophilus. This affirms the known importance of charge-charge interactions in the assembly of the ribosome. We studied the dynamics of three primary proteins from E. coli and T. thermophilus 30S subunits that bind early in the assembly (S15, S17, and S20 with atomic molecular dynamic simulations, followed by a study of all r-proteins using elastic network models. Molecular dynamics simulations show that solvent-exposed proteins (S15 and S17 tend to adopt more stable solution conformations than an RNA-embedded protein (S20. We also find protein residues that contact the 16S rRNA are generally more mobile in comparison with the other residues. This is because there is a larger proportion of contacting residues located in flexible loop regions. By the use of elastic network models, which are computationally more efficient, we show that this trend holds for most of the 30S r-proteins.

  16. Engineering Mathematical Analysis Method for Productivity Rate in Linear Arrangement Serial Structure Automated Flow Assembly Line

    Directory of Open Access Journals (Sweden)

    Tan Chan Sin

    2015-01-01

    Full Text Available Productivity rate (Q or production rate is one of the important indicator criteria for industrial engineer to improve the system and finish good output in production or assembly line. Mathematical and statistical analysis method is required to be applied for productivity rate in industry visual overviews of the failure factors and further improvement within the production line especially for automated flow line since it is complicated. Mathematical model of productivity rate in linear arrangement serial structure automated flow line with different failure rate and bottleneck machining time parameters becomes the basic model for this productivity analysis. This paper presents the engineering mathematical analysis method which is applied in an automotive company which possesses automated flow assembly line in final assembly line to produce motorcycle in Malaysia. DCAS engineering and mathematical analysis method that consists of four stages known as data collection, calculation and comparison, analysis, and sustainable improvement is used to analyze productivity in automated flow assembly line based on particular mathematical model. Variety of failure rate that causes loss of productivity and bottleneck machining time is shown specifically in mathematic figure and presents the sustainable solution for productivity improvement for this final assembly automated flow line.

  17. Relationship between lighting and noise levels and productivity of the occupants in automotive assembly industry.

    Science.gov (United States)

    Akbari, Jafar; Dehghan, Habibollah; Azmoon, Hiva; Forouharmajd, Farhad

    2013-01-01

    Work environment affects human productivity and his performance. The aims of this study were to investigate the effects of lighting and noise levels on human productivity in the automotive assembly industry. Subjects were 181 workers from different parts of an automobile assembly industry. Illuminance (Lx) at the height of 30 inches from the surface of work station and noise (dBA) were locally measured. Also human productivity by the Goldsmith and Hersey scale (1980) was measured. Data were analyzed by using SPSS v20 Pearson correlation coefficient. The results showed that the relationship between noise level and human productivity is negative and significant (P productivity (P > 0.05). Based on the results, in assembly tasks, noise has a negative impact on human productivity, and lighting does not affect this. So, in order to increase employee productivity, noise control and reduction to less than the standard values (less than 85 dB) is necessary.

  18. Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly.

    Science.gov (United States)

    Yeo, Giselle C; Tarakanova, Anna; Baldock, Clair; Wise, Steven G; Buehler, Markus J; Weiss, Anthony S

    2016-02-01

    The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly. We explore the structure-dynamics-function interplay, consider the duality of molecular order and disorder, and identify equally significant functional contributions by local and global structures. To study these organizational stratifications, we perturb a key hinge region by expressing an exon that is universally spliced out in human tropoelastins. We find a herniated nanostructure with a displaced C terminus and explain by molecular modeling that flexible helices are replaced with substantial β sheets. We see atypical higher-order cross-linking and inefficient assembly into discontinuous, thick elastic fibers. We explain this dysfunction by correlating local and global structural effects with changes in the molecule's assembly dynamics. This work has general implications for our understanding of elastomeric proteins, which balance disordered regions with defined structural modules at multiple scales for functional assembly.

  19. Spontaneous Vesicle Self-Assembly: A Mesoscopic View of Membrane Dynamics

    DEFF Research Database (Denmark)

    Shillcock, J. C.

    2012-01-01

    Amphiphilic vesicles are ubiquitous in living cells and industrially interesting as drug delivery vehicles. Vesicle self-assembly proceeds rapidly from nanometer to micrometer length scales and is too fast to image experimentally but too slow for molecular dynamics simulations. Here, we use...... parallel dissipative particle dynamics (DPD) to follow spontaneous vesicle self-assembly for up to 445 mu s with near-molecular resolution. The mean mass and radius of gyration of growing amphiphilic clusters obey power laws with exponents of 0.85 +/- 0.03 and 0.41 +/- 0.02, respectively. We show that DPD...... provides a computational window onto fluid dynamics on scales unreachable by other explicit-solvent simulations....

  20. Dynamic stability of nano-fibers self-assembled from short amphiphilic A6D peptides.

    Science.gov (United States)

    Nikoofard, Narges; Maghsoodi, Fahimeh

    2018-04-07

    Self-assembly of A 6 D amphiphilic peptides in explicit water is studied by using coarse-grained molecular dynamics simulations. It is observed that the self-assembly of randomly distributed A 6 D peptides leads to the formation of a network of nano-fibers. Two other simulations with cylindrical nano-fibers as the initial configuration show the dynamic stability of the self-assembled nano-fibers. As a striking feature, notable fluctuations occur along the axes of the nano-fibers. Depending on the number of peptides per unit length of the nano-fiber, flat-shaped bulges or spiral shapes along the nano-fiber axis are observed at the fluctuations. Analysis of the particle distribution around the nano-fiber indicates that the hydrophobic core and the hydrophilic shell of the nano-structure are preserved in both simulations. The size of the deformations and their correlation times are different in the two simulations. This study gives new insights into the dynamics of the self-assembled nano-structures of short amphiphilic peptides.

  1. Dynamic stability of nano-fibers self-assembled from short amphiphilic A6D peptides

    Science.gov (United States)

    Nikoofard, Narges; Maghsoodi, Fahimeh

    2018-04-01

    Self-assembly of A6D amphiphilic peptides in explicit water is studied by using coarse-grained molecular dynamics simulations. It is observed that the self-assembly of randomly distributed A6D peptides leads to the formation of a network of nano-fibers. Two other simulations with cylindrical nano-fibers as the initial configuration show the dynamic stability of the self-assembled nano-fibers. As a striking feature, notable fluctuations occur along the axes of the nano-fibers. Depending on the number of peptides per unit length of the nano-fiber, flat-shaped bulges or spiral shapes along the nano-fiber axis are observed at the fluctuations. Analysis of the particle distribution around the nano-fiber indicates that the hydrophobic core and the hydrophilic shell of the nano-structure are preserved in both simulations. The size of the deformations and their correlation times are different in the two simulations. This study gives new insights into the dynamics of the self-assembled nano-structures of short amphiphilic peptides.

  2. Programming Cells for Dynamic Assembly of Inorganic Nano-Objects with Spatiotemporal Control.

    Science.gov (United States)

    Wang, Xinyu; Pu, Jiahua; An, Bolin; Li, Yingfeng; Shang, Yuequn; Ning, Zhijun; Liu, Yi; Ba, Fang; Zhang, Jiaming; Zhong, Chao

    2018-04-01

    Programming living cells to organize inorganic nano-objects (NOs) in a spatiotemporally precise fashion would advance new techniques for creating ordered ensembles of NOs and new bio-abiotic hybrid materials with emerging functionalities. Bacterial cells often grow in cellular communities called biofilms. Here, a strategy is reported for programming dynamic biofilm formation for the synchronized assembly of discrete NOs or hetero-nanostructures on diverse interfaces in a dynamic, scalable, and hierarchical fashion. By engineering Escherichia coli to sense blue light and respond by producing biofilm curli fibers, biofilm formation is spatially controlled and the patterned NOs' assembly is simultaneously achieved. Diverse and complex fluorescent quantum dot patterns with a minimum patterning resolution of 100 µm are demonstrated. By temporally controlling the sequential addition of NOs into the culture, multilayered heterostructured thin films are fabricated through autonomous layer-by-layer assembly. It is demonstrated that biologically dynamic self-assembly can be used to advance a new repertoire of nanotechnologies and materials with increasing complexity that would be otherwise challenging to produce. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Dynamic Domains in Data Production Planning

    Science.gov (United States)

    Golden, Keith; Pang, Wanlin

    2005-01-01

    This paper discusses a planner-based approach to automating data production tasks, such as producing fire forecasts from satellite imagery and weather station data. Since the set of available data products is large, dynamic and mostly unknown, planning techniques developed for closed worlds are unsuitable. We discuss a number of techniques we have developed to cope with data production domains, including a novel constraint propagation algorithm based on planning graphs and a constraint-based approach to interleaved planning, sensing and execution.

  4. From one to many: dynamic assembly and collective behavior of self-propelled colloidal motors.

    Science.gov (United States)

    Wang, Wei; Duan, Wentao; Ahmed, Suzanne; Sen, Ayusman; Mallouk, Thomas E

    2015-07-21

    The assembly of complex structures from simpler, individual units is a hallmark of biology. Examples include the pairing of DNA strands, the assembly of protein chains into quaternary structures, the formation of tissues and organs from cells, and the self-organization of bacterial colonies, flocks of birds, and human beings in cities. While the individual behaviors of biomolecules, bacteria, birds, and humans are governed by relatively simple rules, groups assembled from many individuals exhibit complex collective behaviors and functions that do not exist in the absence of the hierarchically organized structure. Self-assembly is a familiar concept to chemists who study the formation and properties of monolayers, crystals, and supramolecular structures. In chemical self-assembly, disorder evolves to order as the system approaches equilibrium. In contrast, living assemblies are typically characterized by two additional features: (1) the system constantly dissipates energy and is not at thermodynamic equilibrium; (2) the structure is dynamic and can transform or disassemble in response to stimuli or changing conditions. To distinguish them from equilibrium self-assembled structures, living (or nonliving) assemblies of objects with these characteristics are referred to as active matter. In this Account, we focus on the powered assembly and collective behavior of self-propelled colloids. These nano- and microparticles, also called nano- and micromotors or microswimmers, autonomously convert energy available in the environment (in the form of chemical, electromagnetic, acoustic, or thermal energy) into mechanical motion. Collections of these colloids are a form of synthetic active matter. Because of the analogy to living swimmers of similar size such as bacteria, the dynamic interactions and collective behavior of self-propelled colloids are interesting in the context of understanding biological active matter and in the development of new applications. The progression

  5. Statistical Methods in Assembly Quality Management of Multi-Element Products on Automatic Rotor Lines

    Science.gov (United States)

    Pries, V. V.; Proskuriakov, N. E.

    2018-04-01

    To control the assembly quality of multi-element mass-produced products on automatic rotor lines, control methods with operational feedback are required. However, due to possible failures in the operation of the devices and systems of automatic rotor line, there is always a real probability of getting defective (incomplete) products into the output process stream. Therefore, a continuous sampling control of the products completeness, based on the use of statistical methods, remains an important element in managing the quality of assembly of multi-element mass products on automatic rotor lines. The feature of continuous sampling control of the multi-element products completeness in the assembly process is its breaking sort, which excludes the possibility of returning component parts after sampling control to the process stream and leads to a decrease in the actual productivity of the assembly equipment. Therefore, the use of statistical procedures for continuous sampling control of the multi-element products completeness when assembled on automatic rotor lines requires the use of such sampling plans that ensure a minimum size of control samples. Comparison of the values of the limit of the average output defect level for the continuous sampling plan (CSP) and for the automated continuous sampling plan (ACSP) shows the possibility of providing lower limit values for the average output defects level using the ACSP-1. Also, the average sample size when using the ACSP-1 plan is less than when using the CSP-1 plan. Thus, the application of statistical methods in the assembly quality management of multi-element products on automatic rotor lines, involving the use of proposed plans and methods for continuous selective control, will allow to automating sampling control procedures and the required level of quality of assembled products while minimizing sample size.

  6. Active Self-Assembled Spinners: dynamic crystals, transport and induced surface flows

    Science.gov (United States)

    Snezhko, Alexey; Kokot, Gasper

    Strongly interacting colloids driven out-of-equilibrium by an external periodic forcing often develop nontrivial collective dynamics. Active magnetic colloids proved to be excellent model experimental systems to explore emergent behavior and active (out-of-equilibrium) self-assembly phenomena. Ferromagnetic micro-particles, suspended at a liquid interface and energized by a rotational homogeneous alternating magnetic field applied along the supporting interface, spontaneously form ensembles of synchronized self-assembled spinners with well-defined characteristic length. The size and the torque of an individual self-assembled spinner are controlled by the frequency of the driving magnetic field. Experiments reveal a rich collective dynamics in large ensembles of synchronized magnetic spinners that spontaneously form dynamic spinner lattices at the interface in a certain range of the excitation parameters. Non-trivial dynamics inside of the formed spinner lattices is observed. Transport of passive cargo particles and structure of the underlying self-induced surface flows is analyzed. The research was supported by the U.S. DOE, Office of Basic Energy Sciences, Division of Materials Science and Engineering.

  7. Dynamic Multi-Component Covalent Assembly for the Reversible Binding of Secondary Alcohols and Chirality Sensing

    Science.gov (United States)

    You, Lei; Berman, Jeffrey S.; Anslyn, Eric V.

    2011-01-01

    Reversible covalent bonding is often employed for the creation of novel supramolecular structures, multi-component assemblies, and sensing ensembles. In spite of remarkable success of dynamic covalent systems, the reversible binding of a mono-alcohol with high strength is challenging. Here we show that a strategy of carbonyl activation and hemiaminal ether stabilization can be embodied in a four-component reversible assembly that creates a tetradentate ligand and incorporates secondary alcohols with exceptionally high affinity. Evidence is presented that the intermediate leading to binding and exchange of alcohols is an iminium ion. Further, to demonstrate the use of this assembly process we explored chirality sensing and enantiomeric excess determinations. An induced twist in the ligand by a chiral mono-ol results in large Cotton effects in the circular dichroism spectra indicative of the alcohol’s handedness. The strategy revealed in this study should prove broadly applicable for the incorporation of alcohols into supramolecular architecture construction. PMID:22109274

  8. Assembly-history dynamics of a pitcher-plant protozoan community in experimental microcosms.

    Directory of Open Access Journals (Sweden)

    Kohmei Kadowaki

    Full Text Available History drives community assembly through differences both in density (density effects and in the sequence in which species arrive (sequence effects. Density effects arise from predictable population dynamics, which are free of history, but sequence effects are due to a density-free mechanism, arising solely from the order and timing of immigration events. Few studies have determined how components of immigration history (timing, number of individuals, frequency alter local dynamics to determine community assembly, beyond addressing when immigration history produces historically contingent assembly.We varied density and sequence effects independently in a two-way factorial design to follow community assembly in a three-species aquatic protozoan community. A superior competitor, Colpoda steinii, mediated alternative community states; early arrival or high introduction density allowed this species to outcompete or suppress the other competitors (Poterioochromonas malhamensis and Eimeriidae gen. sp.. Multivariate analysis showed that density effects caused greater variation in community states, whereas sequence effects altered the mean community composition.A significant interaction between density and sequence effects suggests that we should refine our understanding of priority effects. These results highlight a practical need to understand not only the "ingredients" (species in ecological communities but their "recipes" as well.

  9. Nonequilibrium carrier dynamics in self-assembled InGaAs quantum dots

    International Nuclear Information System (INIS)

    Wesseli, M.; Ruppert, C.; Trumm, S.; Betz, M.; Krenner, H.J.; Finley, J.J.

    2006-01-01

    Carrier dynamics in InGaAs/GaAs quantum dots is analyzed with highly sensitive femtosecond transmission spectroscopy. In a first step, measurements on a large ensemble of nanoislands reveal the dynamical electronic filling of quantum dots from the surrounding wetting layer. Most interestingly, we find a spin-preserving phonon mediated scattering into fully localized states within a few picoseconds. Then, individual artificial atoms are isolated with metallic shadow masks. For the first time, a single self-assembled quantum dot is addressed in an ultrafast transmission experiment. We find bleaching signals in the order of 10 -5 that arise from individual interband transitions of one quantum dot. As a result, we have developed an ultrafast optical tool for both manipulation and read-out of a single self-assembled quantum dot. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  10. Product development projects dynamics and emergent complexity

    CERN Document Server

    Schlick, Christopher

    2016-01-01

    This book primarily explores two topics: the representation of simultaneous, cooperative work processes in product development projects with the help of statistical models, and the assessment of their emergent complexity using a metric from theoretical physics (Effective Measure Complexity, EMC). It is intended to promote more effective management of development projects by shifting the focus from the structural complexity of the product being developed to the dynamic complexity of the development processes involved. The book is divided into four main parts, the first of which provides an introduction to vector autoregression models, periodic vector autoregression models and linear dynamical systems for modeling cooperative work in product development projects. The second part presents theoretical approaches for assessing complexity in the product development environment, while the third highlights and explains closed-form solutions for the complexity metric EMC for vector autoregression models and linear dyn...

  11. Dynamics of Sheep Production in Brazil

    Directory of Open Access Journals (Sweden)

    Samuel Rezende Paiva

    2013-07-01

    Full Text Available Sheep production is present on all continents and has been practiced in Brazil since the colonization. In this study, the multitemporal dynamics of sheep production in Brazil is examined using official government data (Brazilian Institute for Geography and Statistics-IBGE from 1976 to 2010. Maps of flock growth rates and growth acceleration maps by municipality were elaborated. The Southern states are seen to show a reduction in production mainly due to the wool crisis in the 1970s and 80s. The Northeast is seen to be important for meat production. More recently, centerwest and northern states have shown an increase in growth rates but this is still incipient. The maps of growth, acceleration and midpoint for sheep production showed a noticeable return to an increase in production in the South in recent years. The midpoint of production flow was in the northeast direction, which has stagnated. There was great dynamics in sheep production over the whole Brazilian territory, which affected supply chains due to the expansion of domestic and foreign markets. Areas with higher fluctuations in production are more vulnerable in terms of investment policies.

  12. A Modeling approach for analysis and improvement of spindle-holder-tool assembly dynamics

    OpenAIRE

    Budak, Erhan; Ertürk, A.; Erturk, A.; Özgüven, H. N.; Ozguven, H. N.

    2006-01-01

    The most important information required for chatter stability analysis is the dynamics of the involved structures, i.e. the frequency response functions (FRFs) which are usually determined experimentally. In this study, the tool point FRF of a spindle-holder-tool assembly is analytically determined by using the receptance coupling and structural modification techniques. Timoshenko’s beam model is used for increased accuracy. The spindle is also modeled analytically with elastic supports repre...

  13. Nonlinear dynamic behavior of an assembly of tubes under transverse fluid flow

    International Nuclear Information System (INIS)

    Beaufils, B.; Axisa, F.; Antunes, J.

    1989-01-01

    The mechanical vibrations induced by a transverse fluid flow passing through an assembly of cylindrical tubes is investigated. Studies on the numerical modeling of such phenomena are presented. The purpose of the work is to allow the evaluation of the risks induced by the vibrations in industrial heat exchangers. The methods for the analysis of nonlinear problems and numerical calculations of the nonlinear dynamic behavior are performed [fr

  14. The Eating Habits of Giants and Dwarfs: Chemo-dynamics of Halo Assembly in Nearby Galaxies

    Science.gov (United States)

    Romanowsky, Aaron J.; SAGES Team

    2012-01-01

    I will present novel results on the halo assembly of nearby galaxies, from dwarfs to the most massive ellipticals, using Subaru imaging and Keck spectroscopy. Field stars, globular clusters, and planetary nebulae are used as wide-field chemo-dynamical tracers, mapping out halo substructures that were previously known and unknown. Comparisons are made with simulations of galaxy formation. Supported by the National Science Foundation Grants AST-0808099, AST-0909237, and AST-1109878.

  15. Industrial-scale spray layer-by-layer assembly for production of biomimetic photonic systems.

    Science.gov (United States)

    Krogman, K C; Cohen, R E; Hammond, P T; Rubner, M F; Wang, B N

    2013-12-01

    Layer-by-layer assembly is a powerful and flexible thin film process that has successfully reproduced biomimetic photonic systems such as structural colour. While most of the seminal work has been carried out using slow and ultimately unscalable immersion assembly, recent developments using spray layer-by-layer assembly provide a platform for addressing challenges to scale-up and manufacturability. A series of manufacturing systems has been developed to increase production throughput by orders of magnitude, making commercialized structural colour possible. Inspired by biomimetic photonic structures we developed and demonstrated a heat management system that relies on constructive reflection of near infrared radiation to bring about dramatic reductions in heat content.

  16. An Evaluation of Google Glass : Design, Implementation and Evaluation of a Product Assembly Application for Google Glass and Smartphones

    OpenAIRE

    Häger, Johan

    2015-01-01

    Assembling components in a production line could potentially be a tedious task, if performed stepwise by the book. However, an employee who is assembling many different products may not know all the steps by heart. As such they will be reliant on an instruction manual. However, an instruction manual must be carried around and, while assembling components, placed in the assembler's line of sight. Instead new technology could make the process more efficient. Google Glass places a display slight...

  17. Friction welded nonconsumable electrode assembly and use thereof for electrolytic production of metals and silicon

    Science.gov (United States)

    Byrne, Stephen C.; Ray, Siba P.; Rapp, Robert A.

    1984-01-01

    A nonconsumable electrode assembly suitable for use in the production of metal by electrolytic reduction of a metal compound dissolved in a molten salt, the assembly comprising a metal conductor and a ceramic electrode body connected by a friction weld between a portion of the body having a level of free metal or metal alloy sufficient to effect such a friction weld and a portion of the metal conductor.

  18. Self-assembly of actin monomers into long filaments: Brownian Dynamics simulations

    DEFF Research Database (Denmark)

    Shillcock, Julian C.

    2009-01-01

    Brownian dynamics simulations are used to study the dynamical process of self-assembly of actin monomers into long filaments containing up to 1000 actin protomers. In order to overcome the large separation of time scales between the diffusive motion of the freemonomers and the relatively slow....../detachment events. When a single filament is allowed to grow in a bath of constant concentration of free ADP-actin monomers, its growth rate increases linearly with the free monomer concentration in quantitative agreement with in vitro experiments. Theresults also show that the waiting time is governed by...

  19. Dynamics of Major Cereals Productivity in Nepal

    Directory of Open Access Journals (Sweden)

    Samaya Gairhe

    2018-05-01

    Full Text Available Cereal crops have played major roles in addressing food security issues in Nepal. In recent years there have been fluctuations in crop production and demands situations due to various reasons. Thus, the present study aims to analyze the dynamics of major cereals productivity in Nepal from 1995 to 2014. Focus group discussions were done in mid-hills and tarai of Nepal in 2015. Percentage change, compound growth rate, annual rate of change, coefficient of variation, instability index were calculated to analyze results. The result shows that the area, production and productivity of major cereals had an increasing trend over the study period. The major factors contributing on productivity increase in cereal crops were irrigation facilities, use of improved and hybrid seeds, chemical fertilizer and better technical knowhow among the farmers. For effective adoption of research outputs to improve the productivity emphasis should also be given on promotion of public private partnership (PPP in research and development.

  20. Material flow enhancement in production assembly lines under application of zoned order picking systems

    Directory of Open Access Journals (Sweden)

    D. Živanić

    2014-10-01

    Full Text Available Introduced research work relates to the possibility of material flow enhancement in production systems, with the apostrophe on material order picking in production assembly lines. The paper presents basic rules and the results related to formed computer models of zoned order picking systems under the application of developed bound cavities method.

  1. Advantages and Disadvantages of Possible Methods of Managing the Production on the Assembly Lines in the Given Company

    OpenAIRE

    Václavková, Eva

    2014-01-01

    The bachelor thesis deals with methods of lean management, more exactly production planning and managing the production lines assembly. In this thesis, production planning system, kanban cards and heijunka will be described. The aim of this thesis is to describe methods of managing the production lines assembly and to suggest more effective management.

  2. Phase sensitive molecular dynamics of self-assembly glycolipid thin films: A dielectric spectroscopy investigation

    Science.gov (United States)

    Velayutham, T. S.; Ng, B. K.; Gan, W. C.; Majid, W. H. Abd.; Hashim, R.; Zahid, N. I.; Chaiprapa, Jitrin

    2014-08-01

    Glycolipid, found commonly in membranes, is also a liquid crystal material which can self-assemble without the presence of a solvent. Here, the dielectric and conductivity properties of three synthetic glycolipid thin films in different thermotropic liquid crystal phases were investigated over a frequency and temperature range of (10-2-106 Hz) and (303-463 K), respectively. The observed relaxation processes distinguish between the different phases (smectic A, columnar/hexagonal, and bicontinuous cubic Q) and the glycolipid molecular structures. Large dielectric responses were observed in the columnar and bicontinuous cubic phases of the longer branched alkyl chain glycolipids. Glycolipids with the shortest branched alkyl chain experience the most restricted self-assembly dynamic process over the broad temperature range studied compared to the longer ones. A high frequency dielectric absorption (Process I) was observed in all samples. This is related to the dynamics of the hydrogen bond network from the sugar group. An additional low-frequency mechanism (Process II) with a large dielectric strength was observed due to the internal dynamics of the self-assembly organization. Phase sensitive domain heterogeneity in the bicontinuous cubic phase was related to the diffusion of charge carriers. The microscopic features of charge hopping were modelled using the random walk scheme, and two charge carrier hopping lengths were estimated for two glycolipid systems. For Process I, the hopping length is comparable to the hydrogen bond and is related to the dynamics of the hydrogen bond network. Additionally, that for Process II is comparable to the bilayer spacing, hence confirming that this low-frequency mechanism is associated with the internal dynamics within the phase.

  3. Management of research reactor; dynamic characteristics analysis for reactor structures related with vibration of HANARO fuel assembly

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Chang Kee; Shim, Joo Sup [Shinwa Technology Information, Seoul (Korea)

    2001-04-01

    The objective of this study is to deduce the dynamic correlation between the fuel assembly and the reactor structure. Dynamic characteristics analyses for reactor structure related with vibration of HANARO fuel assembly have been performed For the dynamic characteristic analysis, the in-air models of the round and hexagonal flow tubes, 18-element and 36-element fuel assemblies, and reactor structure were developed. By calculating the hydrodynamic mass and distributing it on the in-air models, the in-water models of the flow tubes, the fuel assemblies, and the reactor structure were developed. Then, modal analyses for developed in-air and in-water models have been performed. Especially, two 18-element fuel assemblies and three 36-element fuel assemblies were included in the in-water reactor models. For the verification of the modal analysis results, the natural frequencies and the mode shapes of the fuel assembly were compared with those obtained from the experiment. Finally the analysis results of the reactor structure were compared with them performed by AECL Based on the reactor model without PCS piping, the in-water reactor model including the fuel assemblies was developed, and its modal analysis was performed. The analysis results demonstrate that there are no resonance between the fuel assembly and the reactor structures. 26 refs., 419 figs., 85 tabs. (Author)

  4. The Dynamic Signification of Product Qualities

    DEFF Research Database (Denmark)

    Reijonen, Satu; Tryggestad, Kjell

    2012-01-01

    This article addresses the “greening” of markets by inquiring into how different versions of environmental friendliness of a product are constructed and how they are placed in an order of significance in relation to each other and to other product qualities. The study extends constructivist market...... studies by elaborating on the dynamic signification of product qualities. The case analysis of the development and commercialization of a “polyvinylchloride-free” and “environmentally friendly” urinary drainage bag in the medical devices market shows these qualities to be temporal and fragile outcomes....... It is concluded that, besides a supporting socio-technical market arrangement around the product, the ability of the product to take different matters of concern into account is crucial for the possibility of “greening” markets....

  5. ANALYSIS AND IMPROVEMENT OF PRODUCTION EFFICIENCY IN A CONSTRUCTION MACHINE ASSEMBLY LINE

    Directory of Open Access Journals (Sweden)

    Alidiane Xavier

    2016-07-01

    Full Text Available The increased competitiveness in the market encourages the ongoing development of systems and production processes. The aim is to increase production efficiency to production costs and waste be reduced to the extreme, allowing an increased product competitiveness. The objective of this study was to analyze the overall results of implementing a Kaizen philosophy in an automaker of construction machinery, using the methodology of action research, which will be studied in situ the macro production process from receipt of parts into the end of the assembly line , prioritizing the analysis time of shipping and handling. The results show that the continuous improvement activities directly impact the elimination of waste from the assembly process, mainly related to shipping and handling, improving production efficiency by 30% in the studied processes.

  6. Gradient Dynamics and Entropy Production Maximization

    Science.gov (United States)

    Janečka, Adam; Pavelka, Michal

    2018-01-01

    We compare two methods for modeling dissipative processes, namely gradient dynamics and entropy production maximization. Both methods require similar physical inputs-how energy (or entropy) is stored and how it is dissipated. Gradient dynamics describes irreversible evolution by means of dissipation potential and entropy, it automatically satisfies Onsager reciprocal relations as well as their nonlinear generalization (Maxwell-Onsager relations), and it has statistical interpretation. Entropy production maximization is based on knowledge of free energy (or another thermodynamic potential) and entropy production. It also leads to the linear Onsager reciprocal relations and it has proven successful in thermodynamics of complex materials. Both methods are thermodynamically sound as they ensure approach to equilibrium, and we compare them and discuss their advantages and shortcomings. In particular, conditions under which the two approaches coincide and are capable of providing the same constitutive relations are identified. Besides, a commonly used but not often mentioned step in the entropy production maximization is pinpointed and the condition of incompressibility is incorporated into gradient dynamics.

  7. Effect of fuel assembly mechanical design changes on dynamic response of reactor pressure vessel system under extreme loadings

    International Nuclear Information System (INIS)

    Bhandari, D.R.; Hankinson, M.F.

    1993-01-01

    This paper presents the results of a study to assess the effect of fuel assembly mechanical design changes on the dynamic response of a pressurized water reactor vessel and reactor internals under Loss-Of-Coolant Accident (LOCA) conditions. The results of this study show that the dynamic response of the reactor vessel internals and the core under extreme loadings, such as LOCA, is very sensitive to fuel assembly mechanical design changes. (author)

  8. Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly.

    Science.gov (United States)

    Sardo, Luca; Hatch, Steven C; Chen, Jianbo; Nikolaitchik, Olga; Burdick, Ryan C; Chen, De; Westlake, Christopher J; Lockett, Stephen; Pathak, Vinay K; Hu, Wei-Shau

    2015-11-01

    To increase our understanding of the events that lead to HIV-1 genome packaging, we examined the dynamics of viral RNA and Gag-RNA interactions near the plasma membrane by using total internal reflection fluorescence microscopy. We labeled HIV-1 RNA with a photoconvertible Eos protein via an RNA-binding protein that recognizes stem-loop sequences engineered into the viral genome. Near-UV light exposure causes an irreversible structural change in Eos and alters its emitted fluorescence from green to red. We studied the dynamics of HIV-1 RNA by photoconverting Eos near the plasma membrane, and we monitored the population of photoconverted red-Eos-labeled RNA signals over time. We found that in the absence of Gag, most of the HIV-1 RNAs stayed near the plasma membrane transiently, for a few minutes. The presence of Gag significantly increased the time that RNAs stayed near the plasma membrane: most of the RNAs were still detected after 30 min. We then quantified the proportion of HIV-1 RNAs near the plasma membrane that were packaged into assembling viral complexes. By tagging Gag with blue fluorescent protein, we observed that only a portion, ∼13 to 34%, of the HIV-1 RNAs that reached the membrane were recruited into assembling particles in an hour, and the frequency of HIV-1 RNA packaging varied with the Gag expression level. Our studies reveal the HIV-1 RNA dynamics on the plasma membrane and the efficiency of RNA recruitment and provide insights into the events leading to the generation of infectious HIV-1 virions. Nascent HIV-1 particles assemble on plasma membranes. During the assembly process, HIV-1 RNA genomes must be encapsidated into viral complexes to generate infectious particles. To gain insights into the RNA packaging and virus assembly mechanisms, we labeled and monitored the HIV-1 RNA signals near the plasma membrane. Our results showed that most of the HIV-1 RNAs stayed near the plasma membrane for only a few minutes in the absence of Gag, whereas

  9. Organic production in a dynamic CGE model

    DEFF Research Database (Denmark)

    Jacobsen, Lars Bo

    2004-01-01

    for conventional production into land for organic production, a period of two years must pass before the land being transformed can be used for organic production. During that time, the land is counted as land of the organic industry, but it can only produce the conventional product. To handle this rule, we make......Concerns about the impact of modern agriculture on the environment have in recent years led to an interest in supporting the development of organic farming. In addition to environmental benefits, the aim is to encourage the provision of other “multifunctional” properties of organic farming...... such as rural amenities and rural development that are spillover benefit additional to the supply of food. In this paper we further develop an existing dynamic general equilibrium model of the Danish economy to specifically incorporate organic farming. In the model and input-output data each primary...

  10. Substantiation of strength of TVSA-ALPHA fuel assembly under dynamic seismic loads

    International Nuclear Information System (INIS)

    Tutnov, A.; Kiselev, A.; Kiselev, A.; Krutko, E.; Kiselev, I.; Samoilov, O.; Kaydalov, V.

    2009-01-01

    A special place in the substantiation of the safe operation of fuel assemblies is the assessment their operating capability under seismic loads, leading to short-term (several seconds or tens of seconds) the dynamic effects on the reactor core. The level of acceleration of various elements of the reactor installation can be higher than 1,5 g (g - acceleration of gravity) and depends on the height of these elements relatively the ground, which movement causes an earthquake. This dynamic load cause significant deformation of the active zones design element, in particular of the fuel assemblies (FA), which could lead to a contact (or impact) interaction between them. The report presents the results of studies of stress-strain state of FA of TVSA-ALPHA type under the influence of seismic loads of the 8th level on Richter scale using standard approach. According to a normative approach the natural frequencies and modes of FA are calculated in the preliminary stage. The obtained results are conservative from the point of view that in the real FA design the most loaded SG in the middle of the fuel assemblies are made in a combined with mixing grid variant, which are joint by a common rim. This increases the overall carrying capacity of SG as compared with the calculation SG model. It is also necessary to bear in mind that the dynamic (impact) loading the basic mechanical properties of the material may have a significant difference from static (standard) values. This refers in particular to the yield limit, the value of which can be several times higher than specified in the calculation

  11. Aminobenzoates as building blocks for natural product assembly lines.

    Science.gov (United States)

    Walsh, Christopher T; Haynes, Stuart W; Ames, Brian D

    2012-01-01

    The ortho-, meta-, and para- regioisomers of aminobenzoate are building blocks for a wide range of microbial natural products. Both the ortho-isomer (anthranilate) and PABA derive from the central shikimate pathway metabolite chorismate while the meta-isomer is not available by that route and starts from UDP-3-aminoglucose. PABA is largely funnelled into folate biosynthesis while anthranilate is the scaffold for biosynthetic elaboration into many natural heterocycles, most notably with its role in indole formation for tryptophan biosynthesis. Anthranilate is also converted to benzodiazepinones, fumiquinazolines, quinoxalines, phenoxazines, benzoxazolinates, quinolones, and phenazines, often with redox enzyme participation. The 5-hydroxy form of 3-aminobenzaote is the starter unit for ansa-bridged rifamycins, ansamitocins, and geldanamycins, whereas regioisomers 2-hydroxy, 4-hydroxy and 2,4-dihydroxy-3-aminobenzoate are key components of antimycin, grixazone, and platencin and platensimycin biosynthesis, respectively. The enzymatic mechanisms for generation of the aminobenzoate regioisomers and their subsequent utilization for diverse heterocycle and macrocycle construction are examined.

  12. Adsorption Dynamics and Self-Assembled L-cysteine on Au(100)

    DEFF Research Database (Denmark)

    Engelbrekt, Christian; Nazmutdinov, Renat R.; Yan, Jiawei

    As the only amino acid with a functional thiol group, L - cysteine offers a strong perspective both for binding to gold and other metals, and for gentle immobilization of biomolecules. Binding to single - crystal, atomically planar surfaces offers the additional perspective that bound L - cysteine...... can be structurally mapped at the single - molecule level . In this work, we have followed the adsorption of L - cysteine on single - crystal Au(100) by measuring the electrode potential dynamics during the adsorption process. In situ STM revealed the structure of the self - assembled ordered layers...

  13. Collective Activity of Many Bistable Assemblies Reproduces Characteristic Dynamics of Multistable Perception.

    Science.gov (United States)

    Cao, Robin; Pastukhov, Alexander; Mattia, Maurizio; Braun, Jochen

    2016-06-29

    The timing of perceptual decisions depends on both deterministic and stochastic factors, as the gradual accumulation of sensory evidence (deterministic) is contaminated by sensory and/or internal noise (stochastic). When human observers view multistable visual displays, successive episodes of stochastic accumulation culminate in repeated reversals of visual appearance. Treating reversal timing as a "first-passage time" problem, we ask how the observed timing densities constrain the underlying stochastic accumulation. Importantly, mean reversal times (i.e., deterministic factors) differ enormously between displays/observers/stimulation levels, whereas the variance and skewness of reversal times (i.e., stochastic factors) keep characteristic proportions of the mean. What sort of stochastic process could reproduce this highly consistent "scaling property?" Here we show that the collective activity of a finite population of bistable units (i.e., a generalized Ehrenfest process) quantitatively reproduces all aspects of the scaling property of multistable phenomena, in contrast to other processes under consideration (Poisson, Wiener, or Ornstein-Uhlenbeck process). The postulated units express the spontaneous dynamics of attractor assemblies transitioning between distinct activity states. Plausible candidates are cortical columns, or clusters of columns, as they are preferentially connected and spontaneously explore a restricted repertoire of activity states. Our findings suggests that perceptual representations are granular, probabilistic, and operate far from equilibrium, thereby offering a suitable substrate for statistical inference. Spontaneous reversals of high-level perception, so-called multistable perception, conform to highly consistent and characteristic statistics, constraining plausible neural representations. We show that the observed perceptual dynamics would be reproduced quantitatively by a finite population of distinct neural assemblies, each with

  14. Dynamic structural analysis for assemblies of fuel elements in the core of a PWR

    International Nuclear Information System (INIS)

    Silva Macedo, L.V. da.

    1991-01-01

    It is presented a procedure for the dynamic structural analysis of a PWR core. Impacts between fuel assemblies may occur because of the existence of gaps between them. Thus, the problem is non-linear and an spectral analysis is avoided. It is necessary a time-history response analysis. The Modal Superposition Method with the Duhamel integral was used in order to solve the problem. It is presented an algorithm of solution and also results obtained with the STYCA computer program, developed in the basis of what was proposed here. (author)

  15. A participatory and integrative approach to improve productivity and ergonomics in assembly

    NARCIS (Netherlands)

    Looze, M.P. de; Rhijn, J.W. van; Deursen, J. van; Tuinzaad, G.H.; Reijneveld, C.N.

    2003-01-01

    A participatory and integrative approach was applied to improve the productivity and ergonomics of the assembly lines in two factories, producing magnetic stop valves and office furniture, respectively. Main elements of the approach are the active participation of the company and the integration of

  16. Assembly of Highly Standardized Gene Fragments for High-Level Production of Porphyrins in E. coli

    DEFF Research Database (Denmark)

    Nielsen, Morten Thrane; Madsen, Karina Marie; Seppala, Susanna

    2015-01-01

    to formulate a molecular cloning pipeline and iteratively assemble and optimize a six-gene pathway for protoporphyrin IX synthesis in Escherichia coli. State of the art production levels were achieved through two simple cycles of engineering and screening. The principles defined here are generally applicable...

  17. Design of a full scale model fuel assembly for full power production reactor flow excursion experiments

    International Nuclear Information System (INIS)

    Nash, C.A.; Blake, J.E.; Rush, G.C.

    1990-01-01

    A novel full scale production reactor fuel assembly model was designed and built to study thermal-hydraulic effects of postulated Savannah River Site (SRS) nuclear reactor accidents. The electrically heated model was constructed to simulate the unique annular concentric tube geometry of fuel assemblies in SRS nuclear production reactors. Several major design challenges were overcome in order to produce the prototypic geometry and thermal-hydraulic conditions. The two concentric heater tubes (total power over 6 MW and maximum heat flux of 3.5 MW/m 2 ) (1.1E+6 BTU/(ft 2 hr)) were designed to closely simulate the thermal characteristics of SRS uranium-aluminum nuclear fuel. The paper discusses the design of the model fuel assembly, which met requirements of maintaining prototypic geometric and hydraulic characteristics, and approximate thermal similarity. The model had a cosine axial power profile and the electrical resistance was compatible with the existing power supply. The model fuel assembly was equipped with a set of instruments useful for code analysis, and durable enough to survive a number of LOCA transients. These instruments were sufficiently responsive to record the response of the fuel assembly to the imposed transient

  18. Relationship between Lighting and Noise Levels and Productivity of the Occupants in Automotive Assembly Industry

    Directory of Open Access Journals (Sweden)

    Jafar Akbari

    2013-01-01

    Full Text Available Work environment affects human productivity and his performance. The aims of this study were to investigate the effects of lighting and noise levels on human productivity in the automotive assembly industry. Method. Subjects were 181 workers from different parts of an automobile assembly industry. Illuminance (Lx at the height of 30 inches from the surface of work station and noise (dBA were locally measured. Also human productivity by the Goldsmith and Hersey scale (1980 was measured. Data were analyzed by using SPSS v20 Pearson correlation coefficient. Results. The results showed that the relationship between noise level and human productivity is negative and significant (, , but there was no significant relationship between lighting and human productivity (. Conclusion. Based on the results, in assembly tasks, noise has a negative impact on human productivity, and lighting does not affect this. So, in order to increase employee productivity, noise control and reduction to less than the standard values (less than 85 dB is necessary.

  19. Whole genome assembly of a natto production strain Bacillus subtilis natto from very short read data.

    Science.gov (United States)

    Nishito, Yukari; Osana, Yasunori; Hachiya, Tsuyoshi; Popendorf, Kris; Toyoda, Atsushi; Fujiyama, Asao; Itaya, Mitsuhiro; Sakakibara, Yasubumi

    2010-04-16

    Bacillus subtilis natto is closely related to the laboratory standard strain B. subtilis Marburg 168, and functions as a starter for the production of the traditional Japanese food "natto" made from soybeans. Although re-sequencing whole genomes of several laboratory domesticated B. subtilis 168 derivatives has already been attempted using short read sequencing data, the assembly of the whole genome sequence of a closely related strain, B. subtilis natto, from very short read data is more challenging, particularly with our aim to assemble one fully connected scaffold from short reads around 35 bp in length. We applied a comparative genome assembly method, which combines de novo assembly and reference guided assembly, to one of the B. subtilis natto strains. We successfully assembled 28 scaffolds and managed to avoid substantial fragmentation. Completion of the assembly through long PCR experiments resulted in one connected scaffold for B. subtilis natto. Based on the assembled genome sequence, our orthologous gene analysis between natto BEST195 and Marburg 168 revealed that 82.4% of 4375 predicted genes in BEST195 are one-to-one orthologous to genes in 168, with two genes in-paralog, 3.2% are deleted in 168, 14.3% are inserted in BEST195, and 5.9% of genes present in 168 are deleted in BEST195. The natto genome contains the same alleles in the promoter region of degQ and the coding region of swrAA as the wild strain, RO-FF-1. These are specific for gamma-PGA production ability, which is related to natto production. Further, the B. subtilis natto strain completely lacked a polyketide synthesis operon, disrupted the plipastatin production operon, and possesses previously unidentified transposases. The determination of the whole genome sequence of Bacillus subtilis natto provided detailed analyses of a set of genes related to natto production, demonstrating the number and locations of insertion sequences that B. subtilis natto harbors but B. subtilis 168 lacks

  20. Whole genome assembly of a natto production strain Bacillus subtilis natto from very short read data

    Directory of Open Access Journals (Sweden)

    Fujiyama Asao

    2010-04-01

    Full Text Available Abstract Background Bacillus subtilis natto is closely related to the laboratory standard strain B. subtilis Marburg 168, and functions as a starter for the production of the traditional Japanese food "natto" made from soybeans. Although re-sequencing whole genomes of several laboratory domesticated B. subtilis 168 derivatives has already been attempted using short read sequencing data, the assembly of the whole genome sequence of a closely related strain, B. subtilis natto, from very short read data is more challenging, particularly with our aim to assemble one fully connected scaffold from short reads around 35 bp in length. Results We applied a comparative genome assembly method, which combines de novo assembly and reference guided assembly, to one of the B. subtilis natto strains. We successfully assembled 28 scaffolds and managed to avoid substantial fragmentation. Completion of the assembly through long PCR experiments resulted in one connected scaffold for B. subtilis natto. Based on the assembled genome sequence, our orthologous gene analysis between natto BEST195 and Marburg 168 revealed that 82.4% of 4375 predicted genes in BEST195 are one-to-one orthologous to genes in 168, with two genes in-paralog, 3.2% are deleted in 168, 14.3% are inserted in BEST195, and 5.9% of genes present in 168 are deleted in BEST195. The natto genome contains the same alleles in the promoter region of degQ and the coding region of swrAA as the wild strain, RO-FF-1. These are specific for γ-PGA production ability, which is related to natto production. Further, the B. subtilis natto strain completely lacked a polyketide synthesis operon, disrupted the plipastatin production operon, and possesses previously unidentified transposases. Conclusions The determination of the whole genome sequence of Bacillus subtilis natto provided detailed analyses of a set of genes related to natto production, demonstrating the number and locations of insertion sequences that B

  1. Dilaton dynamics from production of tensionless membranes

    International Nuclear Information System (INIS)

    Cremonini, Sera; Watson, Scott

    2006-01-01

    In this paper we consider classical and quantum corrections to cosmological solutions of 11D supergravity (SUGRA) coming from dynamics of membrane states. We first consider the supermembrane spectrum following the approach of Russo and Tseytlin for consistent quantization. We calculate the production rate of Bogomol'nyi-Prasad-Sommerfield (BPS) membrane bound states in a cosmological background and find that such effects are generically suppressed by the Planck scale, as expected. However, for a modified brane spectrum possessing enhanced symmetry, production can be finite and significant. We stress that this effect could not be anticipated given only a knowledge of the low-energy effective theory. Once on shell, inclusion of these states leads to an attractive force pulling the dilaton towards a fixed point of S-duality, namely g s =1. Although the SUGRA description breaks down in this regime, inclusion of the enhanced states suggests that the center of M-theory moduli space is a dynamical attractor. Moreover, our results seem to suggest that string dynamics does indeed favor a vacuum near fixed points of duality

  2. Dynamic modeling of moment wheel assemblies with nonlinear rolling bearing supports

    Science.gov (United States)

    Wang, Hong; Han, Qinkai; Luo, Ruizhi; Qing, Tao

    2017-10-01

    Moment wheel assemblies (MWA) have been widely used in spacecraft attitude control and large angle slewing maneuvers over the years. Understanding and controlling vibration of MWAs is a crucial factor to achieving the desired level of payload performance. Dynamic modeling of a MWA with nonlinear rolling bearing supports is conducted. An improved load distribution analysis is proposed to more accurately obtain the contact deformations and angles between the rolling balls and raceways. Then, the bearing restoring forces are then obtained through iteratively solving the load distribution equations at every time step. The effects of preload condition, surface waviness, Hertz contact and elastohydrodynamic lubrication could all be reflected in the nonlinear bearing forces. Considering the mass imbalances of the flywheel, flexibility of supporting structures and rolling bearing nonlinearity, the dynamic model of a typical MWA is established based upon the energy theorem. Dynamic tests are conducted to verify the nonlinear dynamic model. The influences of flywheel mass eccentricity and inner/outer waviness amplitudes on the dynamic responses are discussed in detail. The obtained results would be useful for the design and vibration control of the MWA system.

  3. Crossed product algebras associated with topological dynamical systems

    NARCIS (Netherlands)

    Svensson, Pär Christian

    2009-01-01

    We study connections between topological dynamical systems and associated algebras of crossed product type. We derive equivalences between structural properties of a crossed product and dynamical properties of the associated system and furthermore derive qualitative results concerning the crossed

  4. Self-assembly of a constitutional dynamic library of Cu(II) coordination polygons and reversible sorting by crystallization.

    Science.gov (United States)

    Rancan, Marzio; Tessarolo, Jacopo; Zanonato, Pier Luigi; Seraglia, Roberta; Quici, Silvio; Armelao, Lidia

    2013-06-07

    A small coordination constitutional dynamic library (CDL) is self-assembled from Cu(2+) ions and the ortho bis-(3-acetylacetone)benzene ligand. Two coordination polygons, a rhomboid and a triangle, establish a dynamic equilibrium. Quantitative sorting of the rhomboidal polygon is reversibly obtained by crystallization. Thermodynamic and kinetic aspects ruling the CDL system have been elucidated.

  5. Production of solar chemicals: gaining selectivity with hybrid molecule/semiconductor assemblies.

    Science.gov (United States)

    Hennessey, Seán; Farràs, Pau

    2018-05-29

    Research on the production of solar fuels and chemicals has rocketed over the past decade, with a wide variety of systems proposed to harvest solar energy and drive chemical reactions. In this Feature Article we have focused on hybrid molecule/semiconductor assemblies in both powder and supported materials, summarising recent systems and highlighting the enormous possibilities offered by such assemblies to carry out highly demanding chemical reactions with industrial impact. Of relevance is the higher selectivity obtained in visible light-driven organic transformations when using molecular catalysts compared to photocatalytic materials.

  6. Design for manufacturing and assembly key performance indicators to support high-speed product development

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn; Juel Jespersen, Ida Kirstine; Kjærgaard, Thomas

    2018-01-01

    Design for Manufacturing and Assembly (DfMA) has great potential for minimizing late engineering changes (ECs) that impede high-speed product development and delay time-to-profit. However, our understanding of DfMA and its implementation in industry is still incomplete. This paper presents...... an industrial case study on late ECs in high-speed product development and compares the results to other examples from the literature. It then proposes a framework with sets of key performance indicators (KPIs) to measure and improve producability and product quality throughout the product development process....

  7. Visualization of the Serratia Type VI Secretion System Reveals Unprovoked Attacks and Dynamic Assembly

    Directory of Open Access Journals (Sweden)

    Amy J. Gerc

    2015-09-01

    Full Text Available The Type VI secretion system (T6SS is a bacterial nanomachine that fires toxic proteins into target cells. Deployment of the T6SS represents an efficient and widespread means by which bacteria attack competitors or interact with host organisms and may be triggered by contact from an attacking neighbor cell as a defensive strategy. Here, we use the opportunist pathogen Serratia marcescens and functional fluorescent fusions of key components of the T6SS to observe different subassemblies of the machinery simultaneously and on multiple timescales in vivo. We report that the localization and dynamic behavior of each of the components examined is distinct, revealing a multi-stage and dynamic assembly process for the T6SS machinery. We also show that the T6SS can assemble and fire without needing a cell contact trigger, defining an aggressive strategy that broadens target range and suggesting that activation of the T6SS is tailored to survival in specific niches.

  8. Visualization of the Serratia Type VI Secretion System Reveals Unprovoked Attacks and Dynamic Assembly

    Science.gov (United States)

    Gerc, Amy J.; Diepold, Andreas; Trunk, Katharina; Porter, Michael; Rickman, Colin; Armitage, Judith P.; Stanley-Wall, Nicola R.; Coulthurst, Sarah J.

    2015-01-01

    Summary The Type VI secretion system (T6SS) is a bacterial nanomachine that fires toxic proteins into target cells. Deployment of the T6SS represents an efficient and widespread means by which bacteria attack competitors or interact with host organisms and may be triggered by contact from an attacking neighbor cell as a defensive strategy. Here, we use the opportunist pathogen Serratia marcescens and functional fluorescent fusions of key components of the T6SS to observe different subassemblies of the machinery simultaneously and on multiple timescales in vivo. We report that the localization and dynamic behavior of each of the components examined is distinct, revealing a multi-stage and dynamic assembly process for the T6SS machinery. We also show that the T6SS can assemble and fire without needing a cell contact trigger, defining an aggressive strategy that broadens target range and suggesting that activation of the T6SS is tailored to survival in specific niches. PMID:26387948

  9. Dynamic Self-Assembly Induced Rapid Dissolution of Cellulose at Low Temperatures

    International Nuclear Information System (INIS)

    Cai, J.; Zhang, L.; Liu, S.; Liu, Y.; Xu, X.; Chen, X.; Chu, B.; Guo, X.; Xu, J.

    2008-01-01

    Cellulose can be dissolved in precooled (-12 C) 7 wt % NaOH-12 wt % urea aqueous solution within 2 min. This interesting process, to our knowledge, represents the most rapid dissolution of native cellulose. The results from 13C NMR, 15N NMR, 1H NMR, FT-IR, small-angle neutron scattering (SANS), transmission electron microscopy (TEM), and wide-angle X-ray diffraction (WAXD) suggested that NaOH 'hydrates' could be more easily attracted to cellulose chains through the formation of new hydrogen-bonded networks at low temperatures, while the urea hydrates could not be associated directly with cellulose. However, the urea hydrates could possibly be self-assembled at the surface of the NaOH hydrogen-bonded cellulose to form an inclusion complex (IC), leading to the dissolution of cellulose. Scattering experiments, including dynamic and static light scattering, indicated that most cellulose molecules, with limited amounts of aggregation, could exist as extended rigid chains in dilute solution. Further, the cellulose solution was relatively unstable and could be very sensitive to temperature, polymer concentration, and storage time, leading to additional aggregations. TEM images and WAXD provided experimental evidence on the formation of a wormlike cellulose IC being surrounded with urea. Therefore, we propose that the cellulose dissolution at -12 C could arise as a result of a fast dynamic self-assembly process among solvent small molecules (NaOH, urea, and water) and the cellulose macromolecules.

  10. CRAB-II: a computer program to predict hydraulics and scram dynamics of LMFBR control assemblies and its validation

    International Nuclear Information System (INIS)

    Carelli, M.D.; Baker, L.A.; Willis, J.M.; Engel, F.C.; Nee, D.Y.

    1982-01-01

    This paper presents an analytical method, the computer code CRAB-II, which calculates the hydraulics and scram dynamics of LMFBR control assemblies of the rod bundle type and its validation against prototypic data obtained for the Clinch River Breeder Reactor (CRBR) primary control assemblies. The physical-mathematical model of the code is presented, followed by a description of the testing of prototypic CRBR control assemblies in water and sodium to characterize, respectively, their hydraulic and scram dynamics behavior. Comparison of code predictions against the experimental data are presened in detail; excellent agreement was found. Also reported are experimental data and empirical correlations for the friction factor of the absorber bundle in the entire flow range (laminar to turbulent) which represent an extension of the state-of-the-art, since only fuel and blanket assemblies friction factor correlations were previously reported in the open literature

  11. Direction-dependent force-induced dissociation dynamics of an entropic-driven lock-and-key assembly.

    Science.gov (United States)

    Chen, Yen-Fu; Chen, Hsuan-Yi; Sheng, Yu-Jane; Tsao, Heng-Kwong

    2017-09-01

    The unbinding dynamics of a nanosized sphere-and-cavity assembly under the pulling of constant force and constant loading rate is explored by dissipative particle dynamics simulations. The formation of this matched lock-and-key pair in a polymer solution is driven by the depletion attraction. The two-dimensional free energy landscape U(x,z) associated with this assembly is constructed. Our results indicate that the unbinding pathway along the orientation of the assembly is unfavorable due to the relatively high energy barrier compared to that along the tortuous minimum path whose energy barrier is not high. It is also found that the dissociation rate depends on the direction of the external force (θ) with respect to the assembly orientation. The presence of the force component perpendicular to the assembly orientation can reduce the bond lifetime significantly by driving the key particle to approach the minimum path. Moreover, the dissociation dynamics can be facilitated even by a pushing force compared to the spontaneous dissociation (without forces). To elucidate the effective pathway under pulling, the escaping position is analyzed and its mean direction with respect to the assembly orientation rises generally with increasing θ, revealing that the presence of the force component along the minimum pathway is helpful. The importance of the direction of the external pulling has been demonstrated in our simple system. Therefore, this effect should be considered in more complicated unbinding experiments.

  12. Electrode assembly for a lithium ion battery, process for the production of such electrode assembly, and lithium ion battery comprising such electrode assemblies

    NARCIS (Netherlands)

    Mulder, F.M.; Wagemaker, M.

    2013-01-01

    The invention provides an electrode assembly for a lithium ion battery, the electrode assembly comprising a lithium storage electrode layer on a current collector, wherein the lithium storage electrode layer is a porous layer having a porosity in the range of -35 %, with pores having pore widths in

  13. An Optimal Balancing of Multiple Assembly Line For a Batch Production Unit

    Directory of Open Access Journals (Sweden)

    M. Mohan Prasad

    2013-12-01

    Full Text Available Higher Productivity in organizations leads to national prosperity and better standard of living for the whole community. This has motivated several workers on productivity improvement at different levels of XXXX India Pvt Ltd, Chennai. The main objective of this project is to increase the production by changing the layout of the assembly line in making of Transmit Mixer. At present 12 machines are being manufactured in a total of 2 shifts per day. Time study is carried out to identify and avoid the idle time to increase the production rate to 24 machines per day. The organization facing the problems like production time, online inventory, delay and idle time. Here our objective is to reduce the idle time, identifying the cycle time and optimal method of production. The COMSOAL (Computer Method for Sequencing Operations for Assembly Lines and RPW (Ranked Positional Weight algorithms have been used to get the optimal solution. This algorithm provides the better solution, thereby reducing unnecessary movements of the worker within the station. The overall cycle time got reduced when compared with the existing cycle time in order to meet the customer demand. Thus we are proposing this scientific approach to get the optimal solution for increased rate of production of the company without affecting the quality and cost.

  14. CONSIDERATIONS UPON DESIGNING MODULAR CONSTRUCTIONS FOR IMPROVING THE PRODUCTS ASSEMBLING, MAINTENANCE AND RECYCLING PROCESSES

    Directory of Open Access Journals (Sweden)

    BÂRSAN Lucian

    2015-11-01

    Full Text Available Modular constructions are frequently used in industry because of their multiple advantages. Used from the antiquity as a measuring system that ensured good proportions for the objects or buildings, the module is used in present industry as a tool for improving the product maintenance, repair, upgrading, and/or recycling. Modular constructions can be assembled and disassembled easily, facilitating the postuse actions like subassemblies reuse, or materials recovering for the recycling process. An important aspect of this paper is that designers should create the modular solution even from the conceptual design stage and build a structure of functions based on well motivated arguments and which can easily be brake out according to technological possibilities, product functioning and assembly solutions.

  15. Coordinated supply chain dynamic production planning model

    Science.gov (United States)

    Chandra, Charu; Grabis, Janis

    2001-10-01

    Coordination of different and often contradicting interests of individual supply chain members is one of the important issues in supply chain management because the individual members can not succeed without success of the supply chain and vice versa. This paper investigates a supply chain dynamic production planning problem with emphasis on coordination. A planning problem is formally described using a supply chain kernel, which defines supply chain configuration, management policies, available resources and objectives both at supply chain or macro and supply chain member or micro levels. The coordinated model is solved in order to balance decisions made at the macro and micro levels and members' profitability is used as the coordination criterion. The coordinated model is used to determine inventory levels and production capacity across the supply chain. Application of the coordinated model distributes costs burden uniformly among supply chain members and preserves overall efficiency of the supply chain. Influence of the demand series uncertainty is investigated. The production planning model is a part of the integrated supply chain decision modeling system, which is shared among the supply chain members across the Internet.

  16. Input dependent cell assembly dynamics in a model of the striatal medium spiny neuron network

    Directory of Open Access Journals (Sweden)

    Adam ePonzi

    2012-03-01

    Full Text Available The striatal medium spiny neuron (MSNs network is sparsely connected with fairly weak GABAergic collaterals receiving an excitatory glutamatergic cortical projection. Peri stimulus time histograms (PSTH of MSN population response investigated in various experimental studies display strong firing rate modulations distributed throughout behavioural task epochs. In previous work we have shown by numerical simulation that sparse random networks of inhibitory spiking neurons with characteristics appropriate for UP state MSNs form cell assemblies which fire together coherently in sequences on long behaviourally relevant timescales when the network receives a fixed pattern of constant input excitation. Here we first extend that model to the case where cortical excitation is composed of many independent noisy Poisson processes and demonstrate that cell assembly dynamics is still observed when the input is sufficiently weak. However if cortical excitation strength is increased more regularly firing and completely quiescent cells are found, which depend on the cortical stimulation. Subsequently we further extend previous work to consider what happens when the excitatory input varies as it would in when the animal is engaged in behavior. We investigate how sudden switches in excitation interact with network generated patterned activity. We show that sequences of cell assembly activations can be locked to the excitatory input sequence and delineate the range of parameters where this behaviour is shown. Model cell population PSTH display both stimulus and temporal specificity, with large population firing rate modulations locked to elapsed time from task events. Thus the random network can generate a large diversity of temporally evolving stimulus dependent responses even though the input is fixed between switches. We suggest the MSN network is well suited to the generation of such slow coherent task dependent response

  17. Input dependent cell assembly dynamics in a model of the striatal medium spiny neuron network.

    Science.gov (United States)

    Ponzi, Adam; Wickens, Jeff

    2012-01-01

    The striatal medium spiny neuron (MSN) network is sparsely connected with fairly weak GABAergic collaterals receiving an excitatory glutamatergic cortical projection. Peri-stimulus time histograms (PSTH) of MSN population response investigated in various experimental studies display strong firing rate modulations distributed throughout behavioral task epochs. In previous work we have shown by numerical simulation that sparse random networks of inhibitory spiking neurons with characteristics appropriate for UP state MSNs form cell assemblies which fire together coherently in sequences on long behaviorally relevant timescales when the network receives a fixed pattern of constant input excitation. Here we first extend that model to the case where cortical excitation is composed of many independent noisy Poisson processes and demonstrate that cell assembly dynamics is still observed when the input is sufficiently weak. However if cortical excitation strength is increased more regularly firing and completely quiescent cells are found, which depend on the cortical stimulation. Subsequently we further extend previous work to consider what happens when the excitatory input varies as it would when the animal is engaged in behavior. We investigate how sudden switches in excitation interact with network generated patterned activity. We show that sequences of cell assembly activations can be locked to the excitatory input sequence and outline the range of parameters where this behavior is shown. Model cell population PSTH display both stimulus and temporal specificity, with large population firing rate modulations locked to elapsed time from task events. Thus the random network can generate a large diversity of temporally evolving stimulus dependent responses even though the input is fixed between switches. We suggest the MSN network is well suited to the generation of such slow coherent task dependent response which could be utilized by the animal in behavior.

  18. An impact test system design and its applications to dynamic buckling of a spacer grid assembly

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Sheng, E-mail: liusheng_05@126.com; Fan, Chenguang; Yang, Yiren

    2016-11-15

    This study is aimed at investigating the dynamic buckling load, dynamic stiffness, damping and buckling characteristics of the spacer grid assembly (SGA). A pendulum impact test system is designed to experiment the buckling of SGAs. Three criterions are discussed and compared to determine the buckling loads of SGAs: B-R criterion, energy criterion and extreme value criterion. Two approaches are applied to calculate the dynamic stiffness of SGAs: One method is natural period method based on the hypothesis of harmonic motion of the pendulum whose period is approximated because of the passivation and tailing of the impact force time history; and the other is energy method based on the conservation of mechanical energy. The equivalent viscous damping is defined as the resultant cause of dissipation and is obtained by the energy principle. The impact force time history loses its approximate symmetry after buckling occurs. The impact force and displacement reach their maxima almost at the same time at pre-buckling states but not post-buckling states. Vertical straps in SGA are found to be transversely shared by horizontal straps at the buckling position. The buckling of SGA results from the lack of strength of complete structure; and the strength of material has no effects on the buckling.

  19. Numerical evaluation of experimental models to investigate the dynamic behavior of the ITER tokamak assembly

    International Nuclear Information System (INIS)

    Onozuka, M.; Takeda, N.; Nakahira, M.; Shimizu, K.; Nakamura, T.

    2003-01-01

    The most recent assessment method to evaluate the dynamic behavior of the International Thermonuclear Experimental Reactor (ITER) tokamak assembly is outlined. Three experimental models, including a 1/5.8-scale tokamak model, have been considered to validate the numerical analysis methods for dynamic events, particularly seismic ones. The experimental model has been evaluated by numerical calculations and the results are presented. In the calculations, equivalent linearization has been applied for the non-linear characteristics of the support flange connection, caused by the effects of the bolt-fastening and the friction between the flanges. The detailed connecting conditions for the support flanges have been developed and validated for the analysis. Using the conditions, the eigen-mode analysis has shown that the first and second eigen-mode are horizontal vibration modes with the natural frequency of 39 Hz, while the vertical vibration mode is the fourth mode with the natural frequency of 86 Hz. Dynamic analysis for seismic events has shown the maximum acceleration of approximately twofold larger than that of the applied acceleration, and the maximum stress of 104 MPa found in the flange connecting bolt. These values will be examined comparing with experimental results in order to validate the analysis methods

  20. Numerical evaluation of experimental models to investigate the dynamic behavior of the ITER tokamak assembly

    Energy Technology Data Exchange (ETDEWEB)

    Onozuka, M. E-mail: masanori_onozuka@mhi.co.jp; Takeda, N.; Nakahira, M.; Shimizu, K.; Nakamura, T

    2003-09-01

    The most recent assessment method to evaluate the dynamic behavior of the International Thermonuclear Experimental Reactor (ITER) tokamak assembly is outlined. Three experimental models, including a 1/5.8-scale tokamak model, have been considered to validate the numerical analysis methods for dynamic events, particularly seismic ones. The experimental model has been evaluated by numerical calculations and the results are presented. In the calculations, equivalent linearization has been applied for the non-linear characteristics of the support flange connection, caused by the effects of the bolt-fastening and the friction between the flanges. The detailed connecting conditions for the support flanges have been developed and validated for the analysis. Using the conditions, the eigen-mode analysis has shown that the first and second eigen-mode are horizontal vibration modes with the natural frequency of 39 Hz, while the vertical vibration mode is the fourth mode with the natural frequency of 86 Hz. Dynamic analysis for seismic events has shown the maximum acceleration of approximately twofold larger than that of the applied acceleration, and the maximum stress of 104 MPa found in the flange connecting bolt. These values will be examined comparing with experimental results in order to validate the analysis methods.

  1. Boostream: a dynamic fluid flow process to assemble nanoparticles at liquid interface

    Science.gov (United States)

    Delléa, Olivier; Lebaigue, Olivier

    2017-12-01

    CEA-LITEN develops an original process called Boostream® to manipulate, assemble and connect micro- or nanoparticles of various materials, sizes, shapes and functions to obtain monolayer colloidal crystals (MCCs). This process uses the upper surface of a liquid film flowing down a ramp to assemble particles in a manner that is close to the horizontal situation of a Langmuir-Blodgett film construction. In presence of particles at the liquid interface, the film down-flow configuration exhibits an unusual hydraulic jump which results from the fluid flow accommodation to the particle monolayer. In order to master our process, the fluid flow has been modeled and experimentally characterized by optical means, such as with the moiré technique that consists in observing the reflection of a succession of periodic black-and-red fringes on the liquid surface mirror. The fringe images are deformed when reflected by the curved liquid surface associated with the hydraulic jump, the fringe deformation being proportional to the local slope of the surface. This original experimental setup allowed us to get the surface profile in the jump region and to measure it along with the main process parameters (liquid flow rate, slope angle, temperature sensitive fluid properties such as dynamic viscosity or surface tension, particle sizes). This work presents the experimental setup and its simple model, the different experimental characterization techniques used and will focus on the way the hydraulic jump relies on the process parameters.

  2. Protein dynamics during presynaptic complex assembly on individual ssDNA molecules

    Science.gov (United States)

    Gibb, Bryan; Ye, Ling F.; Kwon, YoungHo; Niu, Hengyao; Sung, Patrick; Greene, Eric C.

    2014-01-01

    Homologous recombination is a conserved pathway for repairing double–stranded breaks, which are processed to yield single–stranded DNA overhangs that serve as platforms for presynaptic complex assembly. Here we use single–molecule imaging to reveal the interplay between Saccharomyce cerevisiae RPA, Rad52, and Rad51 during presynaptic complex assembly. We show that Rad52 binds RPA–ssDNA and suppresses RPA turnover, highlighting an unanticipated regulatory influence on protein dynamics. Rad51 binding extends the ssDNA, and Rad52–RPA clusters remain interspersed along the presynaptic complex. These clusters promote additional binding of RPA and Rad52. Together, our work illustrates the spatial and temporal progression of RPA and Rad52 association with the presynaptic complex, and reveals a novel RPA–Rad52–Rad51–ssDNA intermediate, which has implications for understanding how the activities of Rad52 and RPA are coordinated with Rad51 during the later stages recombination. PMID:25195049

  3. De novo protein structure prediction by dynamic fragment assembly and conformational space annealing.

    Science.gov (United States)

    Lee, Juyong; Lee, Jinhyuk; Sasaki, Takeshi N; Sasai, Masaki; Seok, Chaok; Lee, Jooyoung

    2011-08-01

    Ab initio protein structure prediction is a challenging problem that requires both an accurate energetic representation of a protein structure and an efficient conformational sampling method for successful protein modeling. In this article, we present an ab initio structure prediction method which combines a recently suggested novel way of fragment assembly, dynamic fragment assembly (DFA) and conformational space annealing (CSA) algorithm. In DFA, model structures are scored by continuous functions constructed based on short- and long-range structural restraint information from a fragment library. Here, DFA is represented by the full-atom model by CHARMM with the addition of the empirical potential of DFIRE. The relative contributions between various energy terms are optimized using linear programming. The conformational sampling was carried out with CSA algorithm, which can find low energy conformations more efficiently than simulated annealing used in the existing DFA study. The newly introduced DFA energy function and CSA sampling algorithm are implemented into CHARMM. Test results on 30 small single-domain proteins and 13 template-free modeling targets of the 8th Critical Assessment of protein Structure Prediction show that the current method provides comparable and complementary prediction results to existing top methods. Copyright © 2011 Wiley-Liss, Inc.

  4. Aldehyde-functionalized chitosan-montmorillonite films as dynamically-assembled, switchable-chemical release bioplastics.

    Science.gov (United States)

    Chabbi, Jamal; Jennah, Oumayma; Katir, Nadia; Lahcini, Mohamed; Bousmina, Mosto; El Kadib, Abdelkrim

    2018-03-01

    Temporal release of synergistic and/or complementary chemicals (e.g.: drugs) is recognized as extremely challenging because of their frequently intertwined kinetic delivery and presently, straightforward concepts enabling to circumvent this bottleneck are missing in the open literature. In this framework, we report herein on aldehyde-functionalized, transparent and flexible chitosan-montmorillonite hybrid films that act as a new generation of eco-friendly, controlled-chemical release bioplastics. These dynamically-assembled nanomaterials are designed by a ternary assembly from biowaste derived chitin biopolymer, aromatic aldehydes and layered clay nanoparticles. On the basis of their geometrical and conformational properties, the oxygenated groups on the grafted aromatics interact preferentially with either the base Schiff belonging to the carbohydrate (via intramolecular CNHO-Ar known as "imine clip") or with the hydroxyl groups belonging to the clay surface (via intermolecular Si-OHO-Ar). The exfoliated clay nanoparticles within the carbohydrate polymer enables either accelerating or slowing down of the imine (CN) hydrolysis depending on the interaction of the conjugated aromatics. This provides the driving force for fine tuning host-guest interactions at the molecular level and constitutes an entry toward subtle discrimination of different chemicals (e.g. complementary fertilizers, synergistic drugs) during their sequential release. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Skimming or Penetration? Strategic Dynamic Pricing for New Products

    OpenAIRE

    Spann, Martin; Fischer, Marc; Tellis, Gerard J.

    2015-01-01

    Current complex dynamic markets are characterized by numerous brands, each with multiple products and price points, and differentiated on a variety of product attributes plus a large number of new product introductions. This study seeks to analyze dynamic pricing paths in a highly complex branded market, consisting of 663 products under 79 brand names of digital cameras. The authors develop a method to classify dynamic pricing strategies and analyze the choice and correlates of observed prici...

  6. Molecular dynamics of contact behavior of self-assembled monolayers on gold using nanoindentation

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Te-Hua [Institute of Mechanical and Electromechanical Engineering National Formosa University, Yunlin 632, Taiwan (China); Chang, Win-Jin, E-mail: changwj@mail.ksu.edu.tw [Department of Mechanical Engineering Kun Shan University, Tainan 710, Taiwan (China); Fan, Yu-Cheng [Institute of Mechanical and Electromechanical Engineering National Formosa University, Yunlin 632, Taiwan (China); Weng, Cheng-I [Department of Mechanical Engineering National Cheng Kung University, Tainan, 710, Taiwan (China)

    2009-08-15

    Molecular dynamics simulation is used to study nanoindentation of the self-assembled monolayers (SAMs) on an Au surface. The interaction of SAM atoms is described by a general universal force field (UFF), the tight-binding second-moment approximation (TB-SMA) is used for Au substrate, and the Lennard-Jones potential function is employed to describe interaction among the indenter, the SAMs, and the Au substrate atoms. The model consists of a planar Au substrate with n-hexadecanethiol SAM chemisorbed to the substrate. The simulation results show that the contact pressure increases as the SAMs temperature increases. In addition, the contact pressure also increases as the depth and velocity of indentation increase.

  7. Molecular dynamics of contact behavior of self-assembled monolayers on gold using nanoindentation

    International Nuclear Information System (INIS)

    Fang, Te-Hua; Chang, Win-Jin; Fan, Yu-Cheng; Weng, Cheng-I

    2009-01-01

    Molecular dynamics simulation is used to study nanoindentation of the self-assembled monolayers (SAMs) on an Au surface. The interaction of SAM atoms is described by a general universal force field (UFF), the tight-binding second-moment approximation (TB-SMA) is used for Au substrate, and the Lennard-Jones potential function is employed to describe interaction among the indenter, the SAMs, and the Au substrate atoms. The model consists of a planar Au substrate with n-hexadecanethiol SAM chemisorbed to the substrate. The simulation results show that the contact pressure increases as the SAMs temperature increases. In addition, the contact pressure also increases as the depth and velocity of indentation increase.

  8. DNA-programmed dynamic assembly of quantum dots for molecular computation.

    Science.gov (United States)

    He, Xuewen; Li, Zhi; Chen, Muzi; Ma, Nan

    2014-12-22

    Despite the widespread use of quantum dots (QDs) for biosensing and bioimaging, QD-based bio-interfaceable and reconfigurable molecular computing systems have not yet been realized. DNA-programmed dynamic assembly of multi-color QDs is presented for the construction of a new class of fluorescence resonance energy transfer (FRET)-based QD computing systems. A complete set of seven elementary logic gates (OR, AND, NOR, NAND, INH, XOR, XNOR) are realized using a series of binary and ternary QD complexes operated by strand displacement reactions. The integration of different logic gates into a half-adder circuit for molecular computation is also demonstrated. This strategy is quite versatile and straightforward for logical operations and would pave the way for QD-biocomputing-based intelligent molecular diagnostics. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival.

    Science.gov (United States)

    Davì, Valeria; Tanimoto, Hirokazu; Ershov, Dmitry; Haupt, Armin; De Belly, Henry; Le Borgne, Rémi; Couturier, Etienne; Boudaoud, Arezki; Minc, Nicolas

    2018-04-23

    How growing cells cope with size expansion while ensuring mechanical integrity is not known. In walled cells, such as those of microbes and plants, growth and viability are both supported by a thin and rigid encasing cell wall (CW). We deciphered the dynamic mechanisms controlling wall surface assembly during cell growth, using a sub-resolution microscopy approach to monitor CW thickness in live rod-shaped fission yeast cells. We found that polar cell growth yielded wall thinning and that thickness negatively influenced growth. Thickness at growing tips exhibited a fluctuating behavior with thickening phases followed by thinning phases, indicative of a delayed feedback promoting thickness homeostasis. This feedback was mediated by mechanosensing through the CW integrity pathway, which probes strain in the wall to adjust synthase localization and activity to surface growth. Mutants defective in thickness homeostasis lysed by rupturing the wall, demonstrating its pivotal role for walled cell survival. Copyright © 2018 Elsevier Inc. All rights reserved.

  10. NHR dynamic analysis of control rod and fuel assembly of test model

    International Nuclear Information System (INIS)

    Wang Jiachun; Cai Laizhong

    2001-01-01

    The basic purpose is to analyze the dynamic response of the structure, with the seismic excitation, which is the important components of 200 MW Heating Reactor, including the control rod, fuel assembly, zirconium alloy boxes and the relevant parts. The author presents the simplification and building of the model. By comparing the effects under different constraint conditions, the final analyzed model is determined after the preliminary analysis. Then the model is calculated to obtain the frequencies of the model, the analysis of the response spectrum and the time series data under some seismic excitations. From the outcome what is received above, the influence of the basic frequency is discussed. And the displacement and acceleration responses of different sample points are obtained and analyzed to predict the safety of the reactor

  11. Identification of Nonlinear Dynamic Behavior and Failure for Riveted Joint Assemblies

    Directory of Open Access Journals (Sweden)

    B. Langrand

    2000-01-01

    Full Text Available Many different types of rivets need to be modeled to analyze the crashworthiness of aircraft structures. A numerical procedure based on FE modeling and characterization of material failure constitutive models is proposed herein with the aim of limiting the costs of experimental procedures otherwise necessary to obtain these data. Quasi-static and dynamic experiments were carried out on elementary tension (punched and shear (riveted specimens. No strain rate sensitivity was detected in the failure behavior of the riveted joint assemblies. Experimental data were used to identify the Gurson damage parameters of each material (2024-T351 and 7050 aluminum alloys for the sheet metal plate and the rivet respectively by an inverse method. Characterization gave rise to satisfactory correlation between FE models and experiments. Optimized parameters were validated for each material by means of a uniaxial tension test for the sheet metal plate and an ARCAN type specimen in pure tension for the rivet.

  12. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1

    Energy Technology Data Exchange (ETDEWEB)

    Mattiroli, Francesca; Gu, Yajie; Balsbaugh, Jeremy L.; Ahn, Natalie G.; Luger, Karolin

    2017-04-18

    Nucleosome assembly following DNA replication controls epigenome maintenance and genome integrity. Chromatin assembly factor 1 (CAF-1) is the histone chaperone responsible for histone (H3-H4)2 deposition following DNA synthesis. Structural and functional details for this chaperone complex and its interaction with histones are slowly emerging. Using hydrogen-deuterium exchange coupled to mass spectrometry, combined with in vitro and in vivo mutagenesis studies, we identified the regions involved in the direct interaction between the yeast CAF-1 subunits, and mapped the CAF-1 domains responsible for H3-H4 binding. The large subunit, Cac1 organizes the assembly of CAF-1. Strikingly, H3-H4 binding is mediated by a composite interface, shaped by Cac1-bound Cac2 and the Cac1 acidic region. Cac2 is indispensable for productive histone binding, while deletion of Cac3 has only moderate effects on H3-H4 binding and nucleosome assembly. These results define direct structural roles for yeast CAF-1 subunits and uncover a previously unknown critical function of the middle subunit in CAF-1.

  13. Production and cross-sectional characterization of aligned co-electrospun hollow microfibrous bulk assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Feng-Lei [Centre for Imaging Sciences, The University of Manchester, Manchester M13 9PT (United Kingdom); The School of Materials, The University of Manchester, Manchester M13 9PL (United Kingdom); CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester (United Kingdom); Parker, Geoff J.M., E-mail: geoff.parker@manchester.ac.uk [Centre for Imaging Sciences, The University of Manchester, Manchester M13 9PT (United Kingdom); CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester (United Kingdom); Eichhorn, Stephen J. [College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QF (United Kingdom); Hubbard Cristinacce, Penny L. [Centre for Imaging Sciences, The University of Manchester, Manchester M13 9PT (United Kingdom); School of Psychological Sciences, University of Manchester, Manchester M13 9PT (United Kingdom)

    2015-11-15

    The development of co-electrospun (co-ES) hollow microfibrous assemblies of an appreciable thickness is critical for many practical applications, including filtration membranes and tissue-mimicking scaffolds. In this study, thick uniaxially aligned hollow microfibrous assemblies forming fiber bundles and strips were prepared by co-ES of polycaprolactone (PCL) and polyethylene oxide (PEO) as shell and core materials, respectively. Hollow microfiber bundles were deposited on a fixed rotating disc, which resulted in non-controllable cross-sectional shapes on a macroscopic scale. In comparison, fiber strips were produced with tuneable thickness and width by additionally employing an x–y translation stage in co-ES. Scanning electron microscopy (SEM) images of cross-sections of fiber assemblies were analyzed to investigate the effects of production time (from 0.5 h to 12 h), core flow rate (from 0.8 mL/h to 2.0 mL/h) and/or translation speed (from 0.2 mm/s to 5 mm/s) on the pores and porosity. We observed significant changes in pore size and shape with core flow rate but the influence of production time varied; five strips produced under the same conditions had reasonably good size and porosity reproducibility; pore sizes didn't vary significantly from strip bottom to surface, although the porosity gradually decreased and then returned to the initial level. - Highlights: • Hollow microfibrous assemblies based on co-electrospinning are demonstrated. • The thickness and width of co-electrospun strips were controllable. • Cross-sections of fibres had non-normally distributed pore sizes and shapes. • Cross-sections were significantly influenced by production time and flow rate. • Co-electrospun strips had reasonably good reproducible cross-sections.

  14. Design for Manufacture and Assembly for Product Development (Case study : Emergency Lamp)

    Science.gov (United States)

    Ngatilah, Y.; Pulansari, F.; Ernawati, Dira; Pujiastuti, C.; Parwati, C. I.; Prasetyo, B.

    2018-01-01

    Community needs that are not primary but important in everyday life are lights for lighting. State electricity company (PLN) is experiencing limitations in supplying electricity for this puIDRose. Therefore emergency lights (emergency lights) are already marketed in the community, which limited function only illuminate a very limited space. Therefore we developed the design of energy saving lamps using “Light Emitting Diode” (LED) which can illuminate the whole house as well as functioning as mobile phone charger (HP). The method used is Design for Manufacture and Assembly (DFMA), with the result of design development The percentage increase in assembly efficiency (E) is 0.01071 - 0.00645 = 0.00426 or = 39.76%. The decrease in material costs is IDR 234,000 - IDR 214,000 = IDR 20,000 or = 8.54% .Development design is received because of more assembly efficiency than the initial design. Power usage on previous products with series and designs of the original product can last only 4-5 hours non-stop, while the development of the design can survive 9-10 hours 2x more energy efficient.

  15. Self-assembly formation of palm-based esters nano-emulsion: A molecular dynamics study

    Science.gov (United States)

    Abdul Rahman, Mohd. Basyaruddin; Huan, Qiu-Yi; Tejo, Bimo A.; Basri, Mahiran; Salleh, Abu Bakar; Rahman, Raja Noor Zaliha Abdul

    2009-10-01

    Palm-oil esters (POEs) are unsaturated and non-ionic esters that can be prepared by enzymatic synthesis from palm oil. Their nano-emulsion properties possess great potential to act as drug carrier for transdermal drug delivery system. A ratio of 75:5:20 (water/POEs/Span20) was chosen from homogenous region in the phase diagram of our previous experimental work to undergo molecular dynamics simulation. A 15 ns molecular dynamics simulation of nano-emulsion system (water/POEs/Span20) was carried out using OPLS-AA force field. The aggregations of the oil and surfactant molecules are observed throughout the simulation. After 8 ns of simulation, the molecules start to aggregate to form one spherical micelle where the POEs molecules are surrounded by the non-ionic surfactant (Span20) molecules with an average size of 4.2 ± 0.05 nm. The size of the micelle and the ability of palm-based nano-emulsion to self-assemble suggest that this nano-emulsion can potentially use in transdermal drug delivery system.

  16. Probing charge transfer dynamics in self-assembled monolayers by core hole clock approach

    International Nuclear Information System (INIS)

    Zharnikov, Michael

    2015-01-01

    This article reviews recent progress in the application of core hole clock approach in the framework of resonant Auger electron spectroscopy to the monomolecular assembles of alkyl, oligophenyl, and oligo(phenylene–ethynylene) based molecules on Au(1 1 1) substrates, referring mostly to the work by the author et al. The major goal was to study electron transfer (ET) dynamics in these systems serving as prototypes of molecular electronics (ME) devices. The ET pathway to the conductive substrate was unambiguously defined by resonant excitation of the nitrile tailgroup attached to the molecular backbone. Characteristic ET times within the femtosecond domain were determined, along with the attenuation factors for the ET dynamics, analogous to the case of the static transport. The above parameters were found to exhibit strong dependence on the character of the molecular orbital which mediates the ET process. In addition, certain spectral features, which can be associated with an inverse ET from the molecular backbone to the excitation site, were observed upon exchange of the nitrile group by strongly electronegative nitro moiety. The reported results represent a valuable input for theory and a certain potential for applications such as ME devices where optimization of ET can have significant technological impact.

  17. Fuel assemblies

    International Nuclear Information System (INIS)

    Nakatsuka, Masafumi.

    1979-01-01

    Purpose: To prevent scattering of gaseous fission products released from fuel assemblies stored in an fbr type reactor. Constitution; A cap provided with means capable of storing gas is adapted to amount to the assembly handling head, for example, by way of threading in a storage rack of spent fuel assemblies consisting of a bottom plate, a top plate and an assembly support mechanism. By previously eliminating the gas inside of the assembly and the cap in the storage rack, gaseous fission products upon loading, if released from fuel rods during storage, are stored in the cap and do not scatter in the storage rack. (Horiuchi, T.)

  18. Self-assembly, Dynamics and Chirality of Conformational Switches on Metal Surfaces Studied by UHV-STM

    DEFF Research Database (Denmark)

    Nuermaimaiti, Ajiguli

    2013-01-01

    structures formed by the conformational switches and statistical analysis of conformational states, a detailed study of dynamic processes is performed by acquiring time-resolved STM data. Furthermore, one of the possible applications of conformational switches towards inducing chirality in surface assemblies...

  19. Molecular dynamics and energy landscape of decanethiolates in self-assembled monolayers on Au(111) by STM

    NARCIS (Netherlands)

    Sotthewes, Kai; Wu, Hairong; Kumar, Avijit; Vancso, Gyula J.; Schön, Peter Manfred; Zandvliet, Henricus J.W.

    2013-01-01

    The energetics and dynamics of the various phases of decanethiolate self-assembled monolayers on Au(111) surfaces were studied with scanning tunneling microscopy. We have observed five different phases of the decanethiolate monolayer on Au(111): four ordered phases (β, δ, χ*, and ) and one

  20. A universal molecular translator for non-nucleic acid targets that enables dynamic DNA assemblies and logic operations.

    Science.gov (United States)

    Tang, Wei; Hu, Shichao; Wang, Huaming; Zhao, Yan; Li, Na; Liu, Feng

    2014-11-28

    A universal molecular translator based on the target-triggered DNA strand displacement was developed, which was able to convert various kinds of non-nucleic acid targets into a unique output DNA. This translation strategy was successfully applied in directing dynamic DNA assemblies and in realizing three-input logic gate operations.

  1. Visual Perception-Based Statistical Modeling of Complex Grain Image for Product Quality Monitoring and Supervision on Assembly Production Line.

    Directory of Open Access Journals (Sweden)

    Jinping Liu

    Full Text Available Computer vision as a fast, low-cost, noncontact, and online monitoring technology has been an important tool to inspect product quality, particularly on a large-scale assembly production line. However, the current industrial vision system is far from satisfactory in the intelligent perception of complex grain images, comprising a large number of local homogeneous fragmentations or patches without distinct foreground and background. We attempt to solve this problem based on the statistical modeling of spatial structures of grain images. We present a physical explanation in advance to indicate that the spatial structures of the complex grain images are subject to a representative Weibull distribution according to the theory of sequential fragmentation, which is well known in the continued comminution of ore grinding. To delineate the spatial structure of the grain image, we present a method of multiscale and omnidirectional Gaussian derivative filtering. Then, a product quality classifier based on sparse multikernel-least squares support vector machine is proposed to solve the low-confidence classification problem of imbalanced data distribution. The proposed method is applied on the assembly line of a food-processing enterprise to classify (or identify automatically the production quality of rice. The experiments on the real application case, compared with the commonly used methods, illustrate the validity of our method.

  2. Visual Perception-Based Statistical Modeling of Complex Grain Image for Product Quality Monitoring and Supervision on Assembly Production Line.

    Science.gov (United States)

    Liu, Jinping; Tang, Zhaohui; Zhang, Jin; Chen, Qing; Xu, Pengfei; Liu, Wenzhong

    2016-01-01

    Computer vision as a fast, low-cost, noncontact, and online monitoring technology has been an important tool to inspect product quality, particularly on a large-scale assembly production line. However, the current industrial vision system is far from satisfactory in the intelligent perception of complex grain images, comprising a large number of local homogeneous fragmentations or patches without distinct foreground and background. We attempt to solve this problem based on the statistical modeling of spatial structures of grain images. We present a physical explanation in advance to indicate that the spatial structures of the complex grain images are subject to a representative Weibull distribution according to the theory of sequential fragmentation, which is well known in the continued comminution of ore grinding. To delineate the spatial structure of the grain image, we present a method of multiscale and omnidirectional Gaussian derivative filtering. Then, a product quality classifier based on sparse multikernel-least squares support vector machine is proposed to solve the low-confidence classification problem of imbalanced data distribution. The proposed method is applied on the assembly line of a food-processing enterprise to classify (or identify) automatically the production quality of rice. The experiments on the real application case, compared with the commonly used methods, illustrate the validity of our method.

  3. Computational fluid dynamics modeling of two-phase flow in a BWR fuel assembly

    International Nuclear Information System (INIS)

    Andrey Ioilev; Maskhud Samigulin; Vasily Ustinenko; Simon Lo; Adrian Tentner

    2005-01-01

    Full text of publication follows: The goal of this project is to develop an advanced Computational Fluid Dynamics (CFD) computer code (CFD-BWR) that allows the detailed analysis of the two-phase flow and heat transfer phenomena in a Boiling Water Reactor (BWR) fuel bundle under various operating conditions. This code will include more fundamental physical models than the current generation of sub-channel codes and advanced numerical algorithms for improved computational accuracy, robustness, and speed. It is highly desirable to understand the detailed two-phase flow phenomena inside a BWR fuel bundle. These phenomena include coolant phase changes and multiple flow regimes which directly influence the coolant interaction with fuel assembly and, ultimately, the reactor performance. Traditionally, the best analysis tools for the analysis of two-phase flow phenomena inside the BWR fuel assembly have been the sub-channel codes. However, the resolution of these codes is still too coarse for analyzing the detailed intra-assembly flow patterns, such as flow around a spacer element. Recent progress in Computational Fluid Dynamics (CFD), coupled with the rapidly increasing computational power of massively parallel computers, shows promising potential for the fine-mesh, detailed simulation of fuel assembly two-phase flow phenomena. However, the phenomenological models available in the commercial CFD programs are not as advanced as those currently being used in the sub-channel codes used in the nuclear industry. In particular, there are no models currently available which are able to reliably predict the nature of the flow regimes, and use the appropriate sub-models for those flow regimes. The CFD-BWR code is being developed as a customized module built on the foundation of the commercial CFD Code STAR-CD which provides general two-phase flow modeling capabilities. The paper describes the model development strategy which has been adopted by the development team for the

  4. Trapping dynamics of diindenoperylene (DIP) in self-assembled monolayers using molecular simulation

    KAUST Repository

    Kaushik, Ananth P.

    2011-07-01

    All-atom Molecular Dynamics simulation methods employing a well-tested intermolecular potential model, MM3 (Molecular Mechanics 3), demonstrate the propensity for diindenoperylene (DIP) molecules to insert between molecules of a self-assembled monolayer (SAM) during a deposition process intended to grow a thin film of this organic semiconductor molecule onto the surface of self-assembled monolayers. The tendency to insert between SAM molecules is fairly prevalent at normal growth temperatures and conditions, but is most strongly dependent on the density and the nature of the SAM. We posit the existence of an optimal density to favor surface adsorption over insertion for this system. DIP is less likely to insert in fluorinated SAMs, like FOTS (fluorooctatrichlorosilane), than its unfluorinated analog, OTS (octatrichlorosilane). It is also less likely to insert between shorter SAMs (e.g., less insertion in OTS than ODTS (octadecyltrichlorosilane)). Very short length, surface-coating molecules, like HDMS (hexamethyldisilazane), are more likely to scatter energetic incoming DIP molecules with little insertion on first impact (depending on the incident energy of the DIP molecule). Grazing angles of incidence of the depositing molecules generally favor surface adsorption, at least in the limit of low coverage, but are shown to be dependent on the nature of the SAM. The validity of these predictions is confirmed by comparison of the predicted sticking coefficients of DIP at a variety of incident energies on OTS, ODTS, and FOTS SAMs with results obtained experimentally by Desai et al. (2010) [23]. The simulation predictions of the tendency of DIP to insert can be explained, in large part, in terms of binding energies between SAM and DIP molecules. However, we note that entropic and stochastic events play a role in the deposition outcomes. Preliminary studies of multiple deposition events, emulating growth, show an unexpected diffusion of DIP molecules inserted within the

  5. Water ordering controls the dynamic equilibrium of micelle-fibre formation in self-assembly of peptide amphiphiles.

    Science.gov (United States)

    Deshmukh, Sanket A; Solomon, Lee A; Kamath, Ganesh; Fry, H Christopher; Sankaranarayanan, Subramanian K R S

    2016-08-24

    Understanding the role of water in governing the kinetics of the self-assembly processes of amphiphilic peptides remains elusive. Here, we use a multistage atomistic-coarse-grained approach, complemented by circular dichroism/infrared spectroscopy and dynamic light scattering experiments to highlight the dual nature of water in driving the self-assembly of peptide amphiphiles (PAs). We show computationally that water cage formation and breakage near the hydrophobic groups control the fusion dynamics and aggregation of PAs in the micellar stage. Simulations also suggest that enhanced structural ordering of vicinal water near the hydrophilic amino acids shifts the equilibrium towards the fibre phase and stimulates structure and order during the PA assembly into nanofibres. Experiments validate our simulation findings; the measured infrared O-H bond stretching frequency is reminiscent of an ice-like bond which suggests that the solvated water becomes increasingly ordered with time in the assembled peptide network, thus shedding light on the role of water in a self-assembly process.

  6. The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules.

    Science.gov (United States)

    Gulder, Tobias A M; Freeman, Michael F; Piel, Jörn

    2011-03-01

    Bacterial multimodular polyketide synthases (PKSs) are responsible for the biosynthesis of a wide range of pharmacologically active natural products. These megaenzymes contain numerous catalytic and structural domains and act as biochemical templates to generate complex polyketides in an assembly line-like fashion. While the prototypical PKS is composed of only a few different domain types that are fused together in a combinatorial fashion, an increasing number of enzymes is being found that contain additional components. These domains can introduce remarkably diverse modifications into polyketides. This review discusses our current understanding of such noncanonical domains and their role in expanding the biosynthetic versatility of bacterial PKSs.

  7. Molecular dynamic simulation of the self-assembly of DAP12-NKG2C activating immunoreceptor complex.

    Directory of Open Access Journals (Sweden)

    Peng Wei

    Full Text Available The DAP12-NKG2C activating immunoreceptor complex is one of the multisubunit transmembrane protein complexes in which ligand-binding receptor chains assemble with dimeric signal-transducing modules through non-covalent associations in their transmembrane (TM domains. In this work, both coarse grained and atomistic molecular dynamic simulation methods were applied to investigate the self-assembly dynamics of the transmembrane domains of the DAP12-NKG2C activating immunoreceptor complex. Through simulating the dynamics of DAP12-NKG2C TM heterotrimer and point mutations, we demonstrated that a five-polar-residue motif including: 2 Asps and 2 Thrs in DAP12 dimer, as well as 1 Lys in NKG2C TM plays an important role in the assembly structure of the DAP12-NKG2C TM heterotrimer. Furthermore, we provided clear evidences to exclude the possibility that another NKG2C could stably associate with the DAP12-NKG2C heterotrimer. Based on the simulation results, we proposed a revised model for the self-assembly of DAP12-NKG2C activating immunoreceptor complex, along with a plausible explanation for the association of only one NKG2C with a DAP12 dimer.

  8. Dynamics of an assembly of finite-size Lennard-Jones spheres

    International Nuclear Information System (INIS)

    Singh, P.

    1996-01-01

    The time-averaged Fourier spectra of the number density, velocity, and force fields are obtained numerically for an assembly of spherical particles interacting via the Lennard-Jones potential. The magnitude spectra determine the dominant wave numbers, and the phase difference between the Lennard-Jones force and number density spectra determines the nature of the particle dynamics. The latter is used to show that for every wave number k there is a critical frequency ω c (k), such that when ω c (k) the phase difference is π/2 and when ω approx-gt ω c (k) the phase difference is -π/2. The ratio of the frequency and the wave number at which the phase difference changes sign is used to define an effective sound speed for the particle system. The effective sound speed is shown to be a function of the dimensionless wave number, and is locally minimum at the same dimensionless wave numbers for which the static structure factor is minimum. It is also shown that the dynamical response of the particle system for waves with speeds greater than the effective sound speed is similar to the response of the hyperbolic systems of equations, and for waves with speeds smaller than the effective sound speed the response is similar to the response of the elliptic systems. The convection effects are shown to be of the same order of magnitude as the Lennard-Jones forces, and the change of type of the equations from hyperbolic to elliptic occurs when the magnitude of the convection term is comparable to the magnitude of the Lennard-Jones force term. It is also shown that the change of type cannot occur in a theory where the convection term is neglected. copyright 1996 The American Physical Society

  9. The self-assembly, elasticity, and dynamics of cardiac thin filaments.

    Science.gov (United States)

    Tassieri, M; Evans, R M L; Barbu-Tudoran, L; Trinick, J; Waigh, T A

    2008-03-15

    Solutions of intact cardiac thin filaments were examined with transmission electron microscopy, dynamic light scattering (DLS), and particle-tracking microrheology. The filaments self-assembled in solution with a bell-shaped distribution of contour lengths that contained a population of filaments of much greater length than the in vivo sarcomere size ( approximately 1 mum) due to a one-dimensional annealing process. Dynamic semiflexible modes were found in DLS measurements at fast timescales (12.5 ns-0.0001 s). The bending modulus of the fibers is found to be in the range 4.5-16 x 10(-27) Jm and is weakly dependent on calcium concentration (with Ca2+ > or = without Ca2+). Good quantitative agreement was found for the values of the fiber diameter calculated from transmission electron microscopy and from the initial decay of DLS correlation functions: 9.9 nm and 9.7 nm with and without Ca2+, respectively. In contrast, at slower timescales and high polymer concentrations, microrheology indicates that the cardiac filaments act as short rods in solution according to the predictions of the Doi-Edwards chopsticks model (viscosity, eta approximately c(3), where c is the polymer concentration). This differs from the semiflexible behavior of long synthetic actin filaments at comparable polymer concentrations and timescales (elastic shear modulus, G' approximately c(1.4), tightly entangled) and is due to the relative ratio of the contour lengths ( approximately 30). The scaling dependence of the elastic shear modulus on the frequency (omega) for cardiac thin filaments is G' approximately omega(3/4 +/- 0.03), which is thought to arise from flexural modes of the filaments.

  10. Polyubiquitin chain assembly and organisation determine the dynamics of protein activation and degradation

    Directory of Open Access Journals (Sweden)

    Lan K. Nguyen

    2014-01-01

    Full Text Available Protein degradation via ubiquitination is a major proteolytic mechanism in cells. Once a protein is destined for degradation, it is tagged by multiple ubiquitin molecules. The synthesised polyubiquitin chains can be recognised by the 26S proteosome where proteins are degraded. These chains form through multiple ubiquitination cycles that are similar to multi-site phosphorylation cycles. As kinases and phosphatases, two opposing enzymes (E3 ligases and deubiquitinases DUBs catalyse (deubiquitination cycles. Although multi-ubiquitination cycles are fundamental mechanisms of controlling protein concentrations within a cell, their dynamics have never been explored. Here, we fill this knowledge gap. We show that under permissive physiological conditions, the formation of polyubiquitin chain of length greater than two and subsequent degradation of the ubiquitinated protein, which is balanced by protein synthesis, can display bistable, switch-like responses. Interestingly, the occurrence of bistability becomes pronounced, as the chain grows, giving rise to all-or-none regulation at the protein levels. We give predictions of protein distributions under bistable regime awaiting experimental verification. Importantly, we show for the first time that sustained oscillations can robustly arise in the process of formation of ubiquitin chain, largely due to the degradation of the target protein. This new feature is opposite to the properties of multi-site phosphorylation cycles, which are incapable of generating oscillation if the total abundance of interconverted protein forms is conserved. We derive structural and kinetic constraints for the emergence of oscillations, indicating that a competition between different substrate forms and the E3 and DUB is critical for oscillation. Our work provides the first detailed elucidation of the dynamical features brought about by different molecular setups of the polyubiquitin chain assembly process responsible for

  11. Product innovation incentives by an incumbent firm : Dynamic analysis

    NARCIS (Netherlands)

    Dawid, H.; Keoula, M.Y.; Kopel, M.; Kort, Peter

    We employ a dynamic framework to study how product innovation activities of a firm are influenced by its investments in production capacity of an established product and vice versa. The firm initially has capacity to sell an established product. Additionally, it also has the option to undertake an

  12. Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli.

    Science.gov (United States)

    Wang, Jian-Feng; Xiong, Zhi-Qiang; Li, Shi-Yuan; Wang, Yong

    2013-09-01

    Enhancement of the cellular exportation of heterologous compounds is an important aspect to improve the product yield in microbial cell factory. Efflux pumps can expel various intra- or extra-cellular substances out of microbial hosts and increase the cellular tolerance. Thus in this study, by using the hydrophobic sesquiterpene (amorphadiene) and diterpene (kaurene) as two model compounds, we attempted to improve isoprenoid production through systematically engineering the efflux pumps in Escherichia coli BL21(DE3). The pleiotropic resistant pumps, AcrAB-TolC, MdtEF-TolC from E. coli and heterologous MexAB-OprM pump from Pseudomonas aeruginosa, were overexpressed, assembled, and finely modulated. We found that overexpression of AcrB and TolC components can effectively enhance the specific yield of amorphadiene and kaurene, e.g., 31 and 37 % improvement for amorphadiene compared with control, respectively. The heterologous MexB component can enhance kaurene production with 70 % improvement which is more effective than TolC and AcrB. The results suggest that the three components of tripartite efflux pumps play varied effect to enhance isoprenoid production. Considering the highly organized structure of efflux pumps and importance of components interaction, various component combinations were constructed and the copy number of key components AcrB and TolC was finely modulated as well. The results exhibit that the combination TolC and TolC and AcrB improved the specific yield of amorphadiene with 118 %, and AcrA and TolC and AcrB improved that of kaurene with 104 %. This study indicates that assembling and finely modulating efflux pumps is an effective strategy to improve the production of heterologous compounds in E. coli.

  13. Nucleosome Assembly Dynamics Involve Spontaneous Fluctuations in the Handedness of Tetrasomes

    Directory of Open Access Journals (Sweden)

    Rifka Vlijm

    2015-01-01

    Full Text Available DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molecules, we monitor the real-time loading of tetramers or complete histone octamers onto DNA by Nucleosome Assembly Protein-1 (NAP1. Remarkably, we find that tetrasomes exhibit spontaneous flipping between a preferentially occupied left-handed state (ΔLk = −0.73 and a right-handed state (ΔLk = +1.0, separated by a free energy difference of 2.3 kBT (1.5 kcal/mol. This flipping occurs without concomitant changes in DNA end-to-end length. The application of weak positive torque converts left-handed tetrasomes into right-handed tetrasomes, whereas nucleosomes display more gradual conformational changes. Our findings reveal unexpected dynamical rearrangements of the nucleosomal structure, suggesting that chromatin can serve as a “twist reservoir,” offering a mechanistic explanation for the regulation of DNA supercoiling in chromatin.

  14. Assembly and dynamics of the bacteriophage T4 homologous recombination machinery

    Directory of Open Access Journals (Sweden)

    Morrical Scott W

    2010-12-01

    Full Text Available Abstract Homologous recombination (HR, a process involving the physical exchange of strands between homologous or nearly homologous DNA molecules, is critical for maintaining the genetic diversity and genome stability of species. Bacteriophage T4 is one of the classic systems for studies of homologous recombination. T4 uses HR for high-frequency genetic exchanges, for homology-directed DNA repair (HDR processes including DNA double-strand break repair, and for the initiation of DNA replication (RDR. T4 recombination proteins are expressed at high levels during T4 infection in E. coli, and share strong sequence, structural, and/or functional conservation with their counterparts in cellular organisms. Biochemical studies of T4 recombination have provided key insights on DNA strand exchange mechanisms, on the structure and function of recombination proteins, and on the coordination of recombination and DNA synthesis activities during RDR and HDR. Recent years have seen the development of detailed biochemical models for the assembly and dynamics of presynaptic filaments in the T4 recombination system, for the atomic structure of T4 UvsX recombinase, and for the roles of DNA helicases in T4 recombination. The goal of this chapter is to review these recent advances and their implications for HR and HDR mechanisms in all organisms.

  15. Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics.

    Directory of Open Access Journals (Sweden)

    Saisai Wei

    Full Text Available Angiogenin (ANG acts on both vascular endothelial cells and cancer cells, but the underlying mechanism remains elusive. In this study, we carried out a co-immunoprecipitation assay in HeLa cells and identified 14 potential ANG-interacting proteins. Among these proteins, β-actin, α-actinin 4, and non-muscle myosin heavy chain 9 are stress fiber components and involved in cytoskeleton organization and movement, which prompted us to investigate the mechanism of action of ANG in cell migration. Upon confirmation of the interactions between ANG and the three proteins, further studies revealed that ANG co-localized with β-actin and α-actinin 4 at the leading edge of migrating cells. Down-regulation of ANG resulted in fewer but thicker stress fibers with less dynamics, which was associated with the enlargements of focal adhesions. The focal adhesion kinase activity and cell migration capacity were significantly decreased in ANG-deficient cells. Taken together, our data demonstrated that the existence of ANG in the cytoplasm optimizes stress fiber assembly and focal adhesion formation to accommodate cell migration. The finding that ANG promoted cancer cell migration might provide new clues for tumor metastasis research.

  16. Molecular dynamics simulations of surfactant and nanoparticle self-assembly at liquid-liquid interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Luo Mingxiang; Dai, Lenore L [Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409 (United States)

    2007-09-19

    We have performed molecular dynamics (MD) simulations to investigate self-assembly at water-trichloroethylene (TCE) interfaces with the emphasis on systems containing modified hydrocarbon nanoparticles (1.2 nm in diameter) and sodium dodecyl sulfate (SDS) surfactants. The nanoparticles and surfactants were first distributed randomly in the water phase. The MD simulations have clearly shown the progress of migration and final equilibrium of the SDS molecules at the water-TCE interfaces with the nanoparticles either at or in the vicinity of the interfaces. One unique feature is the 'attachment' of surfactant molecules to the nanoparticle clusters in the water phase followed by the 'detachment' at the water-TCE interfaces. At low concentrations of surfactants, the surfactants and nanoparticles co-equilibrate at the interfaces. However, the surfactants, at high concentrations, competitively dominate the interfaces and deplete nanoparticles away from the interfaces. The interfacial properties, such as interfacial thickness and interfacial tension, are significantly influenced by the presence of the surfactants, but not the nanoparticles. The order of the surfactants at the interfaces increases with increasing surfactant concentration, but is independent of nanoparticle concentration. Finally, the simulation has shown that surfactants can aggregate along the water-TCE interfaces, with and without the presence of nanoparticles.

  17. FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics.

    Directory of Open Access Journals (Sweden)

    Ziv Frankenstein

    Full Text Available Studies of the structure and dynamics of macromolecular assemblies often involve comparison of low resolution models obtained using different techniques such as electron microscopy or atomic force microscopy. We present new computational tools for comparing (matching and docking of low resolution structures, based on shape complementarity. The matched or docked objects are represented by three dimensional grids where the value of each grid point depends on its position with regard to the interior, surface or exterior of the object. The grids are correlated using fast Fourier transformations producing either matches of related objects or docking models depending on the details of the grid representations. The procedures incorporate thickening and smoothing of the surfaces of the objects which effectively compensates for differences in the resolution of the matched/docked objects, circumventing the need for resolution modification. The presented matching tool FitEM2EMin successfully fitted electron microscopy structures obtained at different resolutions, different conformers of the same structure and partial structures, ranking correct matches at the top in every case. The differences between the grid representations of the matched objects can be used to study conformation differences or to characterize the size and shape of substructures. The presented low-to-low docking tool FitEM2EMout ranked the expected models at the top.

  18. Dynamic assembly of ultrasoft colloidal networks enables cell invasion within restrictive fibrillar polymers

    Science.gov (United States)

    Douglas, Alison M.; Fragkopoulos, Alexandros A.; Gaines, Michelle K.; Lyon, L. Andrew; Fernandez-Nieves, Alberto; Barker, Thomas H.

    2017-01-01

    In regenerative medicine, natural protein-based polymers offer enhanced endogenous bioactivity and potential for seamless integration with tissue, yet form weak hydrogels that lack the physical robustness required for surgical manipulation, making them difficult to apply in practice. The use of higher concentrations of protein, exogenous cross-linkers, and blending synthetic polymers has all been applied to form more mechanically robust networks. Each relies on generating a smaller network mesh size, which increases the elastic modulus and robustness, but critically inhibits cell spreading and migration, hampering tissue regeneration. Here we report two unique observations; first, that colloidal suspensions, at sufficiently high volume fraction (ϕ), dynamically assemble into a fully percolated 3D network within high-concentration protein polymers. Second, cells appear capable of leveraging these unique domains for highly efficient cell migration throughout the composite construct. In contrast to porogens, the particles in our system remain embedded within the bulk polymer, creating a network of particle-filled tunnels. Whereas this would normally physically restrict cell motility, when the particulate network is created using ultralow cross-linked microgels, the colloidal suspension displays viscous behavior on the same timescale as cell spreading and migration and thus enables efficient cell infiltration of the construct through the colloidal-filled tunnels.

  19. DATA MINING METHODOLOGY FOR DETERMINING THE OPTIMAL MODEL OF COST PREDICTION IN SHIP INTERIM PRODUCT ASSEMBLY

    Directory of Open Access Journals (Sweden)

    Damir Kolich

    2016-03-01

    Full Text Available In order to accurately predict costs of the thousands of interim products that are assembled in shipyards, it is necessary to use skilled engineers to develop detailed Gantt charts for each interim product separately which takes many hours. It is helpful to develop a prediction tool to estimate the cost of interim products accurately and quickly without the need for skilled engineers. This will drive down shipyard costs and improve competitiveness. Data mining is used extensively for developing prediction models in other industries. Since ships consist of thousands of interim products, it is logical to develop a data mining methodology for a shipyard or any other manufacturing industry where interim products are produced. The methodology involves analysis of existing interim products and data collection. Pre-processing and principal component analysis is done to make the data “user-friendly” for later prediction processing and the development of both accurate and robust models. The support vector machine is demonstrated as the better model when there are a lower number of tuples. However as the number of tuples is increased to over 10000, then the artificial neural network model is recommended.

  20. Estimation of neutron production from accelerator head assembly of 15 MV medical LINAC using FLUKA simulations

    Energy Technology Data Exchange (ETDEWEB)

    Patil, B.J., E-mail: bjp@physics.unipune.ac.in [Department of Physics, University of Pune, Pune 411 007 (India); Chavan, S.T., E-mail: sharad@sameer.gov.in [SAMEER, IIT Powai Campus, Mumbai 400 076 (India); Pethe, S.N., E-mail: sanjay@sameer.gov.in [SAMEER, IIT Powai Campus, Mumbai 400 076 (India); Krishnan, R., E-mail: krishnan@sameer.gov.in [SAMEER, IIT Powai Campus, Mumbai 400 076 (India); Bhoraskar, V.N., E-mail: vnb@physics.unipune.ac.in [Department of Physics, University of Pune, Pune 411 007 (India); Dhole, S.D., E-mail: sanjay@physics.unipune.ac.in [Department of Physics, University of Pune, Pune 411 007 (India)

    2011-12-15

    For the production of a clinical 15 MeV photon beam, the design of accelerator head assembly has been optimized using Monte Carlo based FLUKA code. The accelerator head assembly consists of e-{gamma} target, flattening filter, primary collimator and an adjustable rectangular secondary collimator. The accelerators used for radiation therapy generate continuous energy gamma rays called Bremsstrahlung (BR) by impinging high energy electrons on high Z materials. The electron accelerators operating above 10 MeV can result in the production of neutrons, mainly due to photo nuclear reaction ({gamma}, n) induced by high energy photons in the accelerator head materials. These neutrons contaminate the therapeutic beam and give a non-negligible contribution to patient dose. The gamma dose and neutron dose equivalent at the patient plane (SSD = 100 cm) were obtained at different field sizes of 0 Multiplication-Sign 0, 10 Multiplication-Sign 10, 20 Multiplication-Sign 20, 30 Multiplication-Sign 30 and 40 Multiplication-Sign 40 cm{sup 2}, respectively. The maximum neutron dose equivalent is observed near the central axis of 30 Multiplication-Sign 30 cm{sup 2} field size. This is 0.71% of the central axis photon dose rate of 0.34 Gy/min at 1 {mu}A electron beam current.

  1. A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies

    Directory of Open Access Journals (Sweden)

    Delphine Paolantoni

    2015-02-01

    Full Text Available DNA-templated self-assembly is an emerging strategy for generating functional supramolecular systems, which requires the identification of potent multi-point binding ligands. In this line, we recently showed that bis-functionalized guanidinium compounds can interact with ssDNA and generate a supramolecular complex through the recognition of the phosphodiester backbone of DNA. In order to probe the importance of secondary interactions and to identify side groups that stabilize these DNA-templated self-assemblies, we report herein the implementation of a dynamic combinatorial approach. We used an in situ fragment assembly process based on reductive amination and tested various side groups, including amino acids. The results reveal that aromatic and cationic side groups participate in secondary supramolecular interactions that stabilize the complexes formed with ssDNA.

  2. Non-equilibrium magnetic colloidal dispersions at liquid-air interfaces: dynamic patterns, magnetic order and self-assembled swimmers

    International Nuclear Information System (INIS)

    Snezhko, Alexey

    2011-01-01

    Colloidal dispersions of interacting particles subjected to an external periodic forcing often develop nontrivial self-assembled patterns and complex collective behavior. A fundamental issue is how collective ordering in such non-equilibrium systems arises from the dynamics of discrete interacting components. In addition, from a practical viewpoint, by working in regimes far from equilibrium new self-organized structures which are generally not available through equilibrium thermodynamics can be created. In this review spontaneous self-assembly phenomena in magnetic colloidal dispersions suspended at liquid-air interfaces and driven out of equilibrium by an alternating magnetic field are presented. Experiments reveal a new type of nontrivially ordered self-assembled structures emerging in such systems in a certain range of excitation parameters. These dynamic structures emerge as a result of the competition between magnetic and hydrodynamic forces and have complex unconventional magnetic ordering. Nontrivial self-induced hydrodynamic fields accompany each out-of-equilibrium pattern. Spontaneous symmetry breaking of the self-induced surface flows leading to a formation of self-propelled microstructures has been discovered. Some features of the self-localized structures can be understood in the framework of the amplitude equation (Ginzburg-Landau type equation) for parametric waves coupled to the conservation law equation describing the evolution of the magnetic particle density and the Navier-Stokes equation for hydrodynamic flows. To understand the fundamental microscopic mechanisms governing self-assembly processes in magnetic colloidal dispersions at liquid-air interfaces a first-principle model for a non-equilibrium self-assembly is presented. The latter model allows us to capture in detail the entire process of out-of-equilibrium self-assembly in the system and reproduces most of the observed phenomenology. (topical review)

  3. Computational fluid dynamics modeling of two-phase flow in a BWR fuel assembly. Final CRADA Report

    International Nuclear Information System (INIS)

    Tentner, A.

    2009-01-01

    A direct numerical simulation capability for two-phase flows with heat transfer in complex geometries can considerably reduce the hardware development cycle, facilitate the optimization and reduce the costs of testing of various industrial facilities, such as nuclear power plants, steam generators, steam condensers, liquid cooling systems, heat exchangers, distillers, and boilers. Specifically, the phenomena occurring in a two-phase coolant flow in a BWR (Boiling Water Reactor) fuel assembly include coolant phase changes and multiple flow regimes which directly influence the coolant interaction with fuel assembly and, ultimately, the reactor performance. Traditionally, the best analysis tools for this purpose of two-phase flow phenomena inside the BWR fuel assembly have been the sub-channel codes. However, the resolution of these codes is too coarse for analyzing the detailed intra-assembly flow patterns, such as flow around a spacer element. Advanced CFD (Computational Fluid Dynamics) codes provide a potential for detailed 3D simulations of coolant flow inside a fuel assembly, including flow around a spacer element using more fundamental physical models of flow regimes and phase interactions than sub-channel codes. Such models can extend the code applicability to a wider range of situations, which is highly important for increasing the efficiency and to prevent accidents.

  4. Evaluation of the influence of dominance rules for the assembly line design problem under consideration of product design alternatives

    Science.gov (United States)

    Oesterle, Jonathan; Lionel, Amodeo

    2018-06-01

    The current competitive situation increases the importance of realistically estimating product costs during the early phases of product and assembly line planning projects. In this article, several multi-objective algorithms using difference dominance rules are proposed to solve the problem associated with the selection of the most effective combination of product and assembly lines. The list of developed algorithms includes variants of ant colony algorithms, evolutionary algorithms and imperialist competitive algorithms. The performance of each algorithm and dominance rule is analysed by five multi-objective quality indicators and fifty problem instances. The algorithms and dominance rules are ranked using a non-parametric statistical test.

  5. Algorithm of choosing type of mechanical assembly production of instrument making enterprises of Industry 4.0

    Science.gov (United States)

    Zakoldaev, D. A.; Shukalov, A. V.; Zharinov, I. O.; Zharinov, O. O.

    2018-05-01

    The task of the algorithm of choosing the type of mechanical assembly production of instrument making enterprises of Industry 4.0 is being studied. There is a comparison of two project algorithms for Industry 3.0 and Industry 4.0. The algorithm of choosing the type of mechanical assembly production of instrument making enterprises of Industry 4.0 is based on the technological route analysis of the manufacturing process in a company equipped with cyber and physical systems. This algorithm may give some project solutions selected from the primary part or the auxiliary one of the production. The algorithm decisive rules are based on the optimal criterion.

  6. HIV-1 Viral RNA Dynamics at the Plasma Membrane May Provide Insight into Viral Assembly | Poster

    Science.gov (United States)

    Many aspects of how infectious viruses assemble in cells have yet to be completely deciphered. However, as reported in a recent Journal of Virology paper, researchers may be one step closer to understanding how HIV-1, the virus that causes AIDS, assembles and replicates.

  7. Radioactive isotope production for medical applications using Kharkov electron driven subcritical assembly facility.

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, A.; Gohar, Y.; Nuclear Engineering Division

    2007-05-15

    Kharkov Institute of Physics and Technology (KIPT) of Ukraine has a plan to construct an accelerator driven subcritical assembly. The main functions of the subcritical assembly are the medical isotope production, neutron thereby, and the support of the Ukraine nuclear industry. Reactor physics experiments and material research will be carried out using the capabilities of this facility. The United States of America and Ukraine have started collaboration activity for developing a conceptual design for this facility with low enrichment uranium (LEU) fuel. Different conceptual designs are being developed based on the facility mission and the engineering requirements including nuclear physics, neutronics, heat transfer, thermal hydraulics, structure, and material issues. Different fuel designs with LEU and reflector materials are considered in the design process. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements and upgrades. This report is a part of the Argonne National Laboratory Activity within this collaboration for developing and characterizing the subcritical assembly conceptual design. In this study, the medical isotope production function of the Kharkov facility is defined. First, a review was carried out to identify the medical isotopes and its medical use. Then a preliminary assessment was performed without including the self-shielding effect of the irradiated samples. Finally, more detailed investigation was carried out including the self-shielding effect, which defined the sample size and irradiation location for producing each medical isotope. In the first part, the reaction rates were calculated as the multiplication of the cross section with the unperturbed neutron flux of the facility. Over fifty isotopes were considered and all transmutation channels are used including (n,{gamma}), (n,2n), (n,p), and ({gamma},n). In the second part

  8. Radioactive isotope production for medical applications using Kharkov electron driven subcritical assembly facility

    International Nuclear Information System (INIS)

    Talamo, A.; Gohar, Y.

    2007-01-01

    Kharkov Institute of Physics and Technology (KIPT) of Ukraine has a plan to construct an accelerator driven subcritical assembly. The main functions of the subcritical assembly are the medical isotope production, neutron thereby, and the support of the Ukraine nuclear industry. Reactor physics experiments and material research will be carried out using the capabilities of this facility. The United States of America and Ukraine have started collaboration activity for developing a conceptual design for this facility with low enrichment uranium (LEU) fuel. Different conceptual designs are being developed based on the facility mission and the engineering requirements including nuclear physics, neutronics, heat transfer, thermal hydraulics, structure, and material issues. Different fuel designs with LEU and reflector materials are considered in the design process. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements and upgrades. This report is a part of the Argonne National Laboratory Activity within this collaboration for developing and characterizing the subcritical assembly conceptual design. In this study, the medical isotope production function of the Kharkov facility is defined. First, a review was carried out to identify the medical isotopes and its medical use. Then a preliminary assessment was performed without including the self-shielding effect of the irradiated samples. Finally, more detailed investigation was carried out including the self-shielding effect, which defined the sample size and irradiation location for producing each medical isotope. In the first part, the reaction rates were calculated as the multiplication of the cross section with the unperturbed neutron flux of the facility. Over fifty isotopes were considered and all transmutation channels are used including (n,γ), (n,2n), (n,p), and (γ,n). In the second part, the parent

  9. Molecular dynamics simulations of peptide adsorption on self-assembled monolayers

    International Nuclear Information System (INIS)

    Xie Yun; Liu Meifeng; Zhou Jian

    2012-01-01

    All-atom molecular dynamics simulations are performed to investigate the neuromedin-B peptide adsorption on the self-assembled monolayers (SAMs) of SH(CH 2 ) 10 N + (CH 3 ) 2 CH 2 CH(OH)CH 2 SO 3 - (SBT), SH(CH 2 ) 10 OH and SH(CH 2 ) 10 CH 3 . The force-distance profiles show that the surface resistance to peptide adsorption is mainly generated by the water molecules tightly bound to surfaces via hydrogen bonds (hydration water molecules); but surfaces themselves may also set an energy barrier for the approaching peptide. For the SBT-SAM, the surface first exerts a relatively high repulsive force and then a rather week attractive force on the approaching peptide; meanwhile the hydration water molecules exert a strong repulsive force on the peptide. Therefore, SBT-SAM has an excellent performance on resisting protein adsorption. For the OH-SAM and CH 3 -SAM, surfaces show low or little energy barrier but strong affinity to the peptide; and the hydration water molecules apply merely a repulsive force within a much narrower range and with lower intensity compared with the case for the SBT-SAM. The analysis of structural and dynamical properties of the peptide, surface and water indicates that possible factors contributing to surface resistance include the hydrogen-bond formation capability of surfaces, mobility of water molecules near surfaces, surface packing density and chain flexibility of SAMs. There are a large number of hydrogen bonds formed between the hydration water molecules and the functional groups of the SBT-SAM, which greatly lowers the mobility of water molecules near the surface. This tightly-bound water layer effectively reduces the direct contact between the surface and the peptide. Furthermore, the SBT-SAM also has a high flexibility and a low surface packing density, which allows water molecules to penetrate into the surface to form tightly-bound networks and therefore reduces the affinity between the peptide and the surface. The results show that

  10. Production Task Queue Optimization Based on Multi-Attribute Evaluation for Complex Product Assembly Workshop.

    Science.gov (United States)

    Li, Lian-Hui; Mo, Rong

    2015-01-01

    The production task queue has a great significance for manufacturing resource allocation and scheduling decision. Man-made qualitative queue optimization method has a poor effect and makes the application difficult. A production task queue optimization method is proposed based on multi-attribute evaluation. According to the task attributes, the hierarchical multi-attribute model is established and the indicator quantization methods are given. To calculate the objective indicator weight, criteria importance through intercriteria correlation (CRITIC) is selected from three usual methods. To calculate the subjective indicator weight, BP neural network is used to determine the judge importance degree, and then the trapezoid fuzzy scale-rough AHP considering the judge importance degree is put forward. The balanced weight, which integrates the objective weight and the subjective weight, is calculated base on multi-weight contribution balance model. The technique for order preference by similarity to an ideal solution (TOPSIS) improved by replacing Euclidean distance with relative entropy distance is used to sequence the tasks and optimize the queue by the weighted indicator value. A case study is given to illustrate its correctness and feasibility.

  11. Production Task Queue Optimization Based on Multi-Attribute Evaluation for Complex Product Assembly Workshop.

    Directory of Open Access Journals (Sweden)

    Lian-Hui Li

    Full Text Available The production task queue has a great significance for manufacturing resource allocation and scheduling decision. Man-made qualitative queue optimization method has a poor effect and makes the application difficult. A production task queue optimization method is proposed based on multi-attribute evaluation. According to the task attributes, the hierarchical multi-attribute model is established and the indicator quantization methods are given. To calculate the objective indicator weight, criteria importance through intercriteria correlation (CRITIC is selected from three usual methods. To calculate the subjective indicator weight, BP neural network is used to determine the judge importance degree, and then the trapezoid fuzzy scale-rough AHP considering the judge importance degree is put forward. The balanced weight, which integrates the objective weight and the subjective weight, is calculated base on multi-weight contribution balance model. The technique for order preference by similarity to an ideal solution (TOPSIS improved by replacing Euclidean distance with relative entropy distance is used to sequence the tasks and optimize the queue by the weighted indicator value. A case study is given to illustrate its correctness and feasibility.

  12. Dynamics of Cattle Production in Brazil.

    Directory of Open Access Journals (Sweden)

    Concepta McManus

    Full Text Available Movement of livestock production within a country or region has implications for genetics, adaptation, well-being, nutrition, and production logistics, particularly in continental-sized countries, such as Brazil. Cattle production in Brazil from 1977 to 2011 was spatialized, and the annual midpoint of production was calculated. Changes in the relative production and acceleration of production were calculated and spatialized using ARCGIS®. Cluster and canonical discriminant analyses were performed to further highlight differences between regions in terms of cattle production. The mean production point has moved from the Center of Minas Gerais State (in the southeast region to the North of Goiás State (in the Midwest region. This reflects changes in environmental factors, such as pasture type, temperature and humidity. Acceleration in production in the northern region of Brazil has remained strong over the years. More recently, "traditional" cattle-rearing regions, such as the south and southeast, showed a reduction in growth rates as well as a reduction in herd size or internal migration over the period studied. These maps showed that this movement tends to be gradual, with few regions showing high acceleration or deceleration rates.

  13. Study and survey of assembling parameters to a radioactive source production laboratory used to verify equipment

    International Nuclear Information System (INIS)

    Gauglitz, Erica; Nagatomy, Helio Rissei; Moura, Eduardo S.; Zeituni, Carlos Alberto; Hilario, Katia A. Fonseca; Rostelato, Maria Elisa C.M.; Karam Junior, Dib

    2009-01-01

    This paper presents the survey of parameters for the installation and implementation of a laboratory for radioactive sources production at immobilized resin. These sources are used in nuclear medicine for verification of dose calibrators, as the standard guidelines of the National Commission of Nuclear CNEN-NE-3.05 'Radioprotection and safety requirements for nuclear medicine services.' The radioisotopes used for this purpose are: Co-57, Cs-137 and Ba-133, with activities of 185 MBq, 9.3 MBq and 5.4 MBq, respectively. The parameters for the assembly of the laboratory shall be defined according to guidelines that guide the deployment of radiochemical laboratories and standards of the National Commission of Nuclear Energy. (author)

  14. Study and survey of assembling parameters to a radioactive source production laboratory used to verify equipment

    Energy Technology Data Exchange (ETDEWEB)

    Gauglitz, Erica; Nagatomy, Helio Rissei; Moura, Eduardo S.; Zeituni, Carlos Alberto; Hilario, Katia A. Fonseca; Rostelato, Maria Elisa C.M., E-mail: egauglitz@ipen.b, E-mail: elisaros@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Karam Junior, Dib, E-mail: dib.karan@usp.b [Universidade de Sao Paulo (USP), SP (Brazil). Escola de Artes, Ciencias e Humanidades

    2009-07-01

    This paper presents the survey of parameters for the installation and implementation of a laboratory for radioactive sources production at immobilized resin. These sources are used in nuclear medicine for verification of dose calibrators, as the standard guidelines of the National Commission of Nuclear CNEN-NE-3.05 'Radioprotection and safety requirements for nuclear medicine services.' The radioisotopes used for this purpose are: Co-57, Cs-137 and Ba-133, with activities of 185 MBq, 9.3 MBq and 5.4 MBq, respectively. The parameters for the assembly of the laboratory shall be defined according to guidelines that guide the deployment of radiochemical laboratories and standards of the National Commission of Nuclear Energy. (author)

  15. EMMA: An Extensible Mammalian Modular Assembly Toolkit for the Rapid Design and Production of Diverse Expression Vectors.

    Science.gov (United States)

    Martella, Andrea; Matjusaitis, Mantas; Auxillos, Jamie; Pollard, Steven M; Cai, Yizhi

    2017-07-21

    Mammalian plasmid expression vectors are critical reagents underpinning many facets of research across biology, biomedical research, and the biotechnology industry. Traditional cloning methods often require laborious manual design and assembly of plasmids using tailored sequential cloning steps. This process can be protracted, complicated, expensive, and error-prone. New tools and strategies that facilitate the efficient design and production of bespoke vectors would help relieve a current bottleneck for researchers. To address this, we have developed an extensible mammalian modular assembly kit (EMMA). This enables rapid and efficient modular assembly of mammalian expression vectors in a one-tube, one-step golden-gate cloning reaction, using a standardized library of compatible genetic parts. The high modularity, flexibility, and extensibility of EMMA provide a simple method for the production of functionally diverse mammalian expression vectors. We demonstrate the value of this toolkit by constructing and validating a range of representative vectors, such as transient and stable expression vectors (transposon based vectors), targeting vectors, inducible systems, polycistronic expression cassettes, fusion proteins, and fluorescent reporters. The method also supports simple assembly combinatorial libraries and hierarchical assembly for production of larger multigenetic cargos. In summary, EMMA is compatible with automated production, and novel genetic parts can be easily incorporated, providing new opportunities for mammalian synthetic biology.

  16. A system dynamics model to determine products mix

    Directory of Open Access Journals (Sweden)

    Mahtab Hajghasem

    2014-02-01

    Full Text Available This paper presents an implementation of system dynamics model to determine appropriate product mix by considering various factors such as labor, materials, overhead, etc. for an Iranian producer of cosmetic and sanitary products. The proposed model of this paper considers three hypotheses including the relationship between product mix and profitability, optimum production capacity and having minimum amount of storage to take advantage of low cost production. The implementation of system dynamics on VENSIM software package has confirmed all three hypotheses of the survey and suggested that in order to reach better mix product, it is necessary to reach optimum production planning, take advantage of all available production capacities and use inventory management techniques.

  17. Dynamics in international market segmentation of new product growth

    NARCIS (Netherlands)

    Lemmens, A.; Croux, C.; Stremersch, S.

    2012-01-01

    Prior international segmentation studies have been static in that they have identified segments that remain stable over time. This paper shows that country segments in new product growth are intrinsically dynamic. We propose a semiparametric hidden Markov model to dynamically segment countries based

  18. Multi-product dynamic advertisement planning in a segmented market

    Directory of Open Access Journals (Sweden)

    Aggarwal Sugandha

    2017-01-01

    Full Text Available In this paper, a dynamic multi-objective linear integer programming model is proposed to optimally distribute a firm’s advertising budget among multiple products and media in a segmented market. To make the media plan responsive to the changes in the market, the distribution is carried out dynamically by dividing the planning horizon into smaller periods. The model incorporates the effect of the previous period advertising reach on the current period (taken through retention factor, and it also considers cross-product effect of simultaneously advertising different products. An application of the model is presented for an insurance firm that markets five different products, using goal programming approach.

  19. New product development with dynamic decision support

    CSIR Research Space (South Africa)

    Venter, JP

    2007-08-01

    Full Text Available The development of new and improved management methods for new product development is important. Existing methods suffer from a number of shortcomings, especially the ability to deal with a mixture of quantitative and qualitative data. The objective...

  20. New product development with dynamic decision support

    CSIR Research Space (South Africa)

    Venter, Jacobus P

    2009-06-01

    Full Text Available The development of new and improved management methods for new product development is important. Existing methods suffer from a number of shortcomings, especially their inability to deal with a mixture of quantitative and qualitative data...

  1. Market Dynamics and Productivity in Developing Countries

    International Development Research Centre (IDRC) Digital Library (Canada)

    Mining and Quarrying and manufacturing industrial production quantity index ..... Notably, the survival rate of the manufacture of wearing apparel, except footwear ...... Thus, weaknesses in design makes Tunisia's public credit registry a less ...

  2. Supervisory Control Technique For An Assembly Workstation As A Dynamic Discrete Event System

    Directory of Open Access Journals (Sweden)

    Daniela Cristina CERNEGA

    2001-12-01

    Full Text Available This paper proposes a control problem statement in the framework of supervisory control technique for the assembly workstations. A desired behaviour of an assembly workstation is analysed. The behaviour of such a workstation is cyclic and some linguistic properties are established. In this paper, it is proposed an algorithm for the computation of the supremal controllable language of the closed system desired language. Copyright © 2001 IFAC.

  3. Dynamic Self-Assembly of Homogenous Microcyclic Structures Controlled by a Silver-Coated Nanopore.

    Science.gov (United States)

    Gao, Rui; Lin, Yao; Ying, Yi-Lun; Liu, Xiao-Yuan; Shi, Xin; Hu, Yong-Xu; Long, Yi-Tao; Tian, He

    2017-07-01

    The self-assembly of nanoparticles is a challenging process for organizing precise structures with complicated and ingenious structures. In the past decades, a simple, high-efficiency, and reproducible self-assembly method from nanoscale to microscale has been pursued because of the promising and extensive application prospects in bioanalysis, catalysis, photonics, and energy storage. However, microscale self-assembly still faces big challenges including improving the stability and homogeneity as well as pursuing new assembly methods and templates for the uniform self-assembly. To address these obstacles, here, a novel silver-coated nanopore is developed which serves as a template for electrochemically generating microcyclic structures of gold nanoparticles at micrometers with highly homogenous size and remarkable reproducibility. Nanopore-induced microcyclic structures are further applied to visualize the diffusion profile of ionic flux. Based on this novel strategy, a nanopore could potentially facilitate the delivery of assembled structures for many practical applications including drug delivery, cellular detection, catalysis, and plasmonic sensing. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Spiropyran-Decorated SiO₂-Pt Janus Micromotor: Preparation and Light-Induced Dynamic Self-Assembly and Disassembly.

    Science.gov (United States)

    Zhang, Qilu; Dong, Renfeng; Chang, Xueyi; Ren, Biye; Tong, Zhen

    2015-11-11

    The controlled self-assembly of self-propelled Janus micromotors may give the micromotors some potential applications in many fields. In this work, we design a kind of SiO2-Pt Janus catalytic micromotor functionalized by spiropyran (SP) moieties on the surface of the SiO2 hemisphere. The spiropyran-modified SiO2-Pt Janus micromotor exhibits autonomous self-propulsion in the presence of hydrogen peroxide fuel in N,N-dimethylformamide (DMF)/H2O (1:1 in volume) mixture. We demonstrate that the self-propelled Janus micromotors can dynamically assemble into multiple motors because of the electrostatic attractions and π-π stacking between MC molecules induced by UV light irradiation (λ = 365 nm) and also quickly disassemble into mono motors when the light is switched to green light (λ = 520 nm) for the first time. Furthermore, the assembled Janus motors can move together automatically with different motion patterns propelled by the hydrogen peroxide fuels upon UV irradiation. The work provides a new approach not only to the development of the potential application of Janus motors but also to the fundamental science of reversible self-assembly and disassembly of Janus micromotors.

  5. Dynamics of hadron strong production and decay

    International Nuclear Information System (INIS)

    Burns, T. J.; Close, F. E.; Thomas, C. E.

    2008-01-01

    We generalize results of lattice QCD to determine the spin-dependent symmetries and factorization properties of meson production in Okubo-Zweig-Iizuka allowed processes. This explains some conjectures previously made in the literature about axial meson decays and gives predictions for exclusive decays of vector charmonia, including ways of establishing the structure of Y(4260) and Y(4325) from their S-wave decays. Factorization gives a selection rule which forbids e + e - →D*D 2 near threshold with the tensor meson in helicity 2. The relations among amplitudes for double charmonia production e + e - →ψ+χ 0,1,2 are expected to differ from the analogous relations among light flavor production such as e + e - →ωf 0,1,2

  6. Automation Framework for Flight Dynamics Products Generation

    Science.gov (United States)

    Wiegand, Robert E.; Esposito, Timothy C.; Watson, John S.; Jun, Linda; Shoan, Wendy; Matusow, Carla

    2010-01-01

    XFDS provides an easily adaptable automation platform. To date it has been used to support flight dynamics operations. It coordinates the execution of other applications such as Satellite TookKit, FreeFlyer, MATLAB, and Perl code. It provides a mechanism for passing messages among a collection of XFDS processes, and allows sending and receiving of GMSEC messages. A unified and consistent graphical user interface (GUI) is used for the various tools. Its automation configuration is stored in text files, and can be edited either directly or using the GUI.

  7. Adoption of Dynamic Product Information: An Empirical Investigation of Supporting Purchase Decisions on Product Bundles

    OpenAIRE

    Maass, Wolfgang; Kowatsch, Tobias

    2008-01-01

    Up until now, brick-and-mortar stores provide consumers with static product information in the form of printed product labels. This kind of product information does neither adapt to consumer needs nor facilitates new business models (e.g. consumer experience or ad hoc product bundling by products itself). By contrast, dynamic product information provided by mobile recommendation agents (MRA) may leverage these limitations. In this article we formulate a Simplified Consumer Choice (SCC) model ...

  8. Production and characterization of novel self-assembling biosurfactants from Aspergillus flavus.

    Science.gov (United States)

    Ishaq, U; Akram, M S; Iqbal, Z; Rafiq, M; Akrem, A; Nadeem, M; Shafi, F; Shafiq, Z; Mahmood, S; Baig, M A

    2015-10-01

    This work was conducted to produce, purify and characterize biosurfactants from Aspergillus flavus AF612 isolated from citrus fruit. Biosurfactant named 'Uzmaq' was isolated from A. flavus AF612. The chemical characterization of the biosurfactant was conducted. Biosurfactant Uzmaq produced by A. flavus, was composed of methoxy phenyl oxime glycosides. Two molecular forms of the biosurfactant, Uzmaq-A and Uzmaq-B were isolated. Biological properties (antifungal activity) were evaluated. The fractions of the biosurfactant were isolated and their surface properties were analysed. Uzmaq-A and Uzmaq-B had critical micelle concentration (CMC) around 170 and 80 mg l(-1) , and lowered surface tension of water up to 20 and 25 m Nm(-1) respectively. The biosurfactants were stable at pH 3-12 and temperature up to 80°C. Growth and biosurfactant production kinetics were also analysed. Novel biosurfactant Uzmaq was produced from A. flavus, which was composed of methoxy phenyl oxime glycosides. The surface activity of Uzmaq was better than the maximum values of synthetic chemical surfactants. The biosurfactant showed antifungal activity and self-assembling properties. Aspergillus flavus AF612 can be used for commercial production of Uzmaq that may be employed for controlled drug release applications and bioremediation. © 2015 The Society for Applied Microbiology.

  9. Dynamic Investment Strategies and Leadership in Product Innovation

    NARCIS (Netherlands)

    Dawid, H.; Keoula, M.Y.; Kopel, M.; Kort, Peter

    2017-01-01

    We employ a dynamic market model with endogenous creation of submarkets to study the optimal product innovation strategies of incumbent firms. Firms invest in production capacity and R&D knowledge stock, where the latter determines the hazard rate of innovation. We find that under Markov Perfect

  10. Random walk in genome space: A key ingredient of intermittent dynamics of community assembly on evolutionary time scales

    KAUST Repository

    Murase, Yohsuke

    2010-06-01

    Community assembly is studied using individual-based multispecies models. The models have stochastic population dynamics with mutation, migration, and extinction of species. Mutants appear as a result of mutation of the resident species, while migrants have no correlation with the resident species. It is found that the dynamics of community assembly with mutations are quite different from the case with migrations. In contrast to mutation models, which show intermittent dynamics of quasi-steady states interrupted by sudden reorganizations of the community, migration models show smooth and gradual renewal of the community. As a consequence, instead of the 1/f diversity fluctuations found for the mutation models, 1/f2, random-walk like fluctuations are observed for the migration models. In addition, a characteristic species-lifetime distribution is found: a power law that is cut off by a "skewed" distribution in the long-lifetime regime. The latter has a longer tail than a simple exponential function, which indicates an age-dependent species-mortality function. Since this characteristic profile has been observed, both in fossil data and in several other mathematical models, we conclude that it is a universal feature of macroevolution. © 2010 Elsevier Ltd.

  11. Random walk in genome space: A key ingredient of intermittent dynamics of community assembly on evolutionary time scales

    KAUST Repository

    Murase, Yohsuke; Shimada, Takashi; Ito, Nobuyasu; Rikvold, Per Arne

    2010-01-01

    Community assembly is studied using individual-based multispecies models. The models have stochastic population dynamics with mutation, migration, and extinction of species. Mutants appear as a result of mutation of the resident species, while migrants have no correlation with the resident species. It is found that the dynamics of community assembly with mutations are quite different from the case with migrations. In contrast to mutation models, which show intermittent dynamics of quasi-steady states interrupted by sudden reorganizations of the community, migration models show smooth and gradual renewal of the community. As a consequence, instead of the 1/f diversity fluctuations found for the mutation models, 1/f2, random-walk like fluctuations are observed for the migration models. In addition, a characteristic species-lifetime distribution is found: a power law that is cut off by a "skewed" distribution in the long-lifetime regime. The latter has a longer tail than a simple exponential function, which indicates an age-dependent species-mortality function. Since this characteristic profile has been observed, both in fossil data and in several other mathematical models, we conclude that it is a universal feature of macroevolution. © 2010 Elsevier Ltd.

  12. Lateral hydraulic forces calculation on PWR fuel assemblies with computational fluid dynamics codes

    International Nuclear Information System (INIS)

    Corpa Masa, R.; Jimenez Varas, G.; Moreno Garcia, B.

    2016-01-01

    To be able to simulate the behavior of nuclear fuel under operating conditions, it is required to include all the representative loads, including the lateral hydraulic forces which were not included traditionally because of the difficulty of calculating them in a reliable way. Thanks to the advance in CFD codes, now it is possible to assess them. This study calculates the local lateral hydraulic forces, caused by the contraction and expansion of the flow due to the bow of the surrounding fuel assemblies, on of fuel assembly under typical operating conditions from a three loop Westinghouse PWR reactor. (Author)

  13. Joint Dynamic Pricing of Multiple Perishable Products Under Consumer Choice

    OpenAIRE

    Yalç{\\i}n Akçay; Harihara Prasad Natarajan; Susan H. Xu

    2010-01-01

    In response to competitive pressures, firms are increasingly adopting revenue management opportunities afforded by advances in information and communication technologies. Motivated by these revenue management initiatives in industry, we consider a dynamic pricing problem facing a firm that sells given initial inventories of multiple substitutable and perishable products over a finite selling horizon. Because the products are substitutable, individual product demands are linked through consume...

  14. SPATIAL DYNAMICS OF CEARÁ’S COCONUT PRODUCTION

    Directory of Open Access Journals (Sweden)

    Leandro Vieira Cavalcante

    2017-07-01

    Full Text Available The main purpose of this article is to discuss the spatial dynamics of coconut production in the State of Ceará (Brazil while highlighting the spatialization of this process and the characterization of the coconut production spaces in Ceará’s territory. It also debates the effect agricultural activity has on the space production process, empirically evidenced from the coconut cultivation analysis.

  15. Dynamic molecular oxygen production in cometary comae

    Science.gov (United States)

    Yao, Yunxi; Giapis, Konstantinos P.

    2017-05-01

    Abundant molecular oxygen was discovered in the coma of comet 67P/Churyumov-Gerasimenko. Its origin was ascribed to primordial gaseous O2 incorporated into the nucleus during the comet's formation. This thesis was put forward after discounting several O2 production mechanisms in comets, including photolysis and radiolysis of water, solar wind-surface interactions and gas-phase collisions. Here we report an original Eley-Rideal reaction mechanism, which permits direct O2 formation in single collisions of energetic water ions with oxidized cometary surface analogues. The reaction proceeds by H2O+ abstracting a surface O-atom, then forming an excited precursor state, which dissociates to produce O2-. Subsequent photo-detachment leads to molecular O2, whose presence in the coma may thus be linked directly to water molecules and their interaction with the solar wind. This abiotic O2 production mechanism is consistent with reported trends in the 67P coma and raises awareness of the role of energetic negative ions in comets.

  16. Dynamical simulation of electron transfer processes in self-assembled monolayers at metal surfaces using a density matrix approach

    Science.gov (United States)

    Prucker, V.; Bockstedte, M.; Thoss, M.; Coto, P. B.

    2018-03-01

    A single-particle density matrix approach is introduced to simulate the dynamics of heterogeneous electron transfer (ET) processes at interfaces. The characterization of the systems is based on a model Hamiltonian parametrized by electronic structure calculations and a partitioning method. The method is applied to investigate ET in a series of nitrile-substituted (poly)(p-phenylene)thiolate self-assembled monolayers adsorbed at the Au(111) surface. The results show a significant dependence of the ET on the orbital symmetry of the donor state and on the molecular and electronic structure of the spacer.

  17. Dynamical simulation of electron transfer processes in self-assembled monolayers at metal surfaces using a density matrix approach.

    Science.gov (United States)

    Prucker, V; Bockstedte, M; Thoss, M; Coto, P B

    2018-03-28

    A single-particle density matrix approach is introduced to simulate the dynamics of heterogeneous electron transfer (ET) processes at interfaces. The characterization of the systems is based on a model Hamiltonian parametrized by electronic structure calculations and a partitioning method. The method is applied to investigate ET in a series of nitrile-substituted (poly)(p-phenylene)thiolate self-assembled monolayers adsorbed at the Au(111) surface. The results show a significant dependence of the ET on the orbital symmetry of the donor state and on the molecular and electronic structure of the spacer.

  18. Dynamic Covalent Self-Assembly of Mono-, Bi- and Trimacro-cycles from Hydrogen Bonded Preorganized Templates

    Institute of Scientific and Technical Information of China (English)

    LIN Jianbin; WU Jing; JIANG Xikui; LI Zhanting

    2009-01-01

    This paper describes the dynamic covalent assembly of three mono-, bi- and trimacrocycles by utilizing hydro-gen bonding-driven zigzag anthranilamides as "leading" components. The monomacrocycle, a tetraamino molecule, was prepared from the [24+2] coupling reaction of a "'U"-shaped dialdehyde and a porphyrin diamine, followed by the reduction of the macrocyclic tetraimine by NaBH3CN, while the bi-and trimacrocycles were obtained through two six-component coupling reactions with rigid tri- and tetraamino-appended oligomers as templates.

  19. Direct and quantitative characterization of dynamic ligand exchange between coordination-driven self-assembled supramolecular polygons.

    Science.gov (United States)

    Zheng, Yao-Rong; Stang, Peter J

    2009-03-18

    The direct observation of dynamic ligand exchange between Pt-N coordination-driven self-assembled supramolecular polygons (triangles and rectangles) has been achieved using stable (1)H/(2)D isotope labeling of the pyridyl donors and electrospray ionization mass spectrometry combined with NMR spectroscopy. Both the thermodynamic and kinetic aspects of such exchange processes have been established on the basis of quantitative mass spectral results. Further investigation has shown that the exchange is highly dependent on experimental conditions such as temperature, solvent, and the counteranions.

  20. The effects of the pedestal/floor interface on the dynamic characteristics of the storage ring girder support assemblies

    International Nuclear Information System (INIS)

    Jendrzejczyk, J.A.; Chen, S.S.; Zhu, S.; Mangra, D.; Smith, R.K.

    1993-05-01

    To avoid unacceptable vibration of the storage ring quadrupoles, and to ensure that the established vibration criteria are satisfied, the philosophy from inception of the APS has been (1) to locate and design the machine to minimize motion of the storage ring basemat and, (2) following construction, to monitor machine operation and user experiments to ensure that vibration sources are not introduced. This report addresses the design of the storage ring girder support assemblies, and, specifically, the effect of the pedestal/floor interface on the dynamic characteristics (i.e., resonant frequencies, damping, and mode shape)

  1. Changes in Dimensionality and Fractal Scaling Suggest Soft-Assembled Dynamics in Human EEG

    DEFF Research Database (Denmark)

    Wiltshire, Travis; Euler, Matthew J.; McKinney, Ty

    2017-01-01

    Humans are high-dimensional, complex systems consisting of many components that must coordinate in order to perform even the simplest of activities. Many behavioral studies, especially in the movement sciences, have advanced the notion of soft-assembly to describe how systems with many components...

  2. The plutonium product: design of the rod and of the assembly

    International Nuclear Information System (INIS)

    Francillon, G.

    1985-10-01

    On the base of physical and experimental data the aim to be reached is to design a mixed oxide-fuel rod and a mixed oxide-fuel assembly which will be introduced in a PWR type reactor while ensuring the operation and safety of the unit required presently. This paper presents successively the MOX fuel rod and the MOX fuel assembly [fr

  3. A Neural Assembly-Based View on Word Production: The Bilingual Test Case

    Science.gov (United States)

    Strijkers, Kristof

    2016-01-01

    I will propose a tentative framework of how words in two languages could be organized in the cerebral cortex based on neural assembly theory, according to which neurons that fire synchronously are bound into large-scale distributed functional units (assemblies), which represent a mental event as a whole ("gestalt"). For language this…

  4. Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli.

    Science.gov (United States)

    Stahlhut, Steen G; Siedler, Solvej; Malla, Sailesh; Harrison, Scott J; Maury, Jérôme; Neves, Ana Rute; Forster, Jochen

    2015-09-01

    Plant secondary metabolites are an underutilized pool of bioactive molecules for applications in the food, pharma and nutritional industries. One such molecule is fisetin, which is present in many fruits and vegetables and has several potential health benefits, including anti-cancer, anti-viral and anti-aging activity. Moreover, fisetin has recently been shown to prevent Alzheimer's disease in mice and to prevent complications associated with diabetes type I. Thus far the biosynthetic pathway of fisetin in plants remains elusive. Here, we present the heterologous assembly of a novel fisetin pathway in Escherichia coli. We propose a novel biosynthetic pathway from the amino acid, tyrosine, utilizing nine heterologous enzymes. The pathway proceeds via the synthesis of two flavanones never produced in microorganisms before--garbanzol and resokaempferol. We show for the first time a functional biosynthetic pathway and establish E. coli as a microbial platform strain for the production of fisetin and related flavonols. Copyright © 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

  5. Measurement of the ^235mU Production Cross Section Using a Critical Assembly*

    Science.gov (United States)

    Macri, Robert; Authier, Nicolas; Becker, John; Belier, Gilbert; Bond, Evelyn; Bredeweg, Todd; Glover, S.; Meot, Vincent; Rundberg, Robert; Vieira, David; Wilhelmy, Jerry

    2006-10-01

    Measurements of the creation and destruction cross sections for actinide nuclei constitute an important experimental effort in support of Stockpile Stewardship. In this talk I will give a progress report on the effort to measure the production cross section of the ^235mU isomer integrated over a fission neutron spectrum. This ongoing experiment is fielded at CEA in Valduc, France, taking advantage of the CALIBAN critical assembly. This effort is performed in collaboration with LANL, LLNL, Bruyeres le Chatel, and Valduc staff. This experiment utilizes a technique to measure internal conversion electrons from the ^235mU isomer with the French BIII detector (Bruyeres le Chatel), and involves a substantial chemistry effort (LANL) to prepare targets for irradiation and counting, as well as to remove fission fragments after irradiation. Experimental techniques will be discussed and preliminary data presented. *Work performed under the auspices of the U.S. Department of Energy by Los Alamos National Laboratory (W-7405-ENG-36) and Lawrence Livermore National Laboratory (W-7405-ENG-48), and CEA-DAM under CEA-DAM NNSA-DOE agreement.

  6. Dynamic products shaping information to engage and persuade

    CERN Document Server

    Colombo, Sara

    2016-01-01

    This book explores how dynamic changes in products' sensory features can be used to convey information to the user in an effective and engaging way. The aim is to supply the reader with a clear understanding of an important emerging area of research and practice in product design, referred to as dynamic products, which is opening up new possibilities for the integration of product design with digital and smart technologies and offering an alternative to the use of digital interfaces. Dynamic products are artifacts displaying sensory characteristics – visual, tactile, auditory, or olfactory – that change in a proactive and reversible way over time, addressing one or more of the user's senses. The reader will learn why and how to communicate by means of such dynamic products. Their potential advantages and limitations are identified and design tools are proposed to support the design activity. It is hoped that the book will stimulate the design community to reflect upon the ever more compelling need to merg...

  7. Delayed nonlinear cournot and bertrand dynamics with product differentiation.

    Science.gov (United States)

    Matsumoto, Akio; Szidarovszky, Ferenc

    2007-07-01

    Dynamic duopolies will be examined with product differentiation and isoelastic price functions. We will first prove that under realistic conditions the equilibrium is always locally asymptotically stable. The stability can however be lost if the firms use delayed information in forming their best responses. Stability conditions are derived in special cases, and simulation results illustrate the complexity of the dynamism of the systems. Both price and quantity adjusting models are discussed.

  8. Analysis and results of a hydrogen-moderated isotope production assembly in the Fast Flux Test Facility

    International Nuclear Information System (INIS)

    Wootan, D.W.; Rawlins, J.A.; Carter, L.L.; Brager, H.R.; Schenter, R.E.

    1989-01-01

    This paper reports on a cobalt test assembly containing yttrium hydride pins for neutron moderation irradiated in the Fast Flux Test Facility (FFTF) during cycle 9A for 137.7 equivalent full-power days at a power level of 291 MW. The 36 test pins consisted of a batch of 32 pins containing cobalt metal used to produce 60 Co and a set of four pins with europium oxide to produce 153 Gd, a radioisotope used in detection of the bone disease osteoporosis. Postirradiation examination of the cobalt pins determined the 60 Co production to be predictable to an accuracy of ∼ 5%. The measured 60 Co spatially distributed concentrations were within 20% of the calculated concentrations. The assembly average 60 Co measured activity was 4% less than the calculated value. The europium oxide pins were gamma scanned for the europium isotopes 152 Eu and 154 Eu to an absolute accuracy of ≅ 10%. The measured europium radioisotope and 153 Gd concentrations were within 20% of calculated values. The hydride assembly performed well and is an excellent vehicle for many FFTF isotope production applications. The results also demonstrate the accuracy of the calculational methods developed by the Westinghouse Hanford Company for predicting isotope production rates in this type of assembly

  9. Structural, optical and Carrier dynamics of self-assembled InGaN nanocolumns on Si(111)

    Science.gov (United States)

    Kumar, Praveen; Devi, Pooja; Soto Rodriguez, P. E. D.; Jain, Rishabh; Jaggi, Neena; Sinha, R. K.; Kumar, Mahesh

    2018-05-01

    We investigated the morphological, structural, optical, electrical and carrier relaxation dynamic changes on the self-assembled grown InGaN nanocolumns (NCs) directly on p-Si(111) substrate at two different substrate temperature, namely 580 °C (A) and 500 °C (B). The emission wavelength of comparably low temperature (LT) grown NCs was red-shifted from 3.2eV to 2.4eV. First observations on the charge carrier dynamics of these directly grown NCs show comparable broad excited state absorption (ESA) for LT gown NCs, which manifest bi-exponential decay due to the radiative defects generated during the coalescence of these NCs.

  10. Physiological evidence of interpersonal dynamics in a cooperative production task

    DEFF Research Database (Denmark)

    Mønster, Dan; Håkonsson, Dorthe Døjbak; Eskildsen, Jacob Kjær

    2016-01-01

    Recent research suggests that shared behavioral dynamics during interpersonal interaction are indicative of subjective and objective outcomes of the interaction, such as feelings of rapport and success of performance. The role of shared physiological dynamics to quantify interpersonal interaction...... production task. Moreover, high team synchrony is found indicative of team cohesion, while low team synchrony is found indicative of a teams' decision to adopt a new behavior across multiple production sessions. We conclude that team-level measures of synchrony offer new and complementary information...

  11. The dynamics of rice production in Indonesia 1961–2009

    Directory of Open Access Journals (Sweden)

    Dyah R. Panuju

    2013-01-01

    Full Text Available Rice is one of the important agricultural products in Indonesia. The production has been fully supported by infrastructure including research and development as well as government regulations in pricing. Its vulnerability to climate change requires adaptation strategies on irrigation, biotechnology and selection of alternative crops. The primary goal of this paper was to evaluate the historical perspective of the dynamics of rice production, technologies particularly in seed inventions, labour in farming and consumption of rice from 1961 to 2009 in conjunction with land capability. The study of historical rice production could be a benefit for future agricultural planning in Indonesia.

  12. Control of dynamical self-assembly of strongly Brownian nanoparticles through convective forces induced by ultrafast laser

    Science.gov (United States)

    Ilday, Serim; Akguc, Gursoy B.; Tokel, Onur; Makey, Ghaith; Yavuz, Ozgun; Yavuz, Koray; Pavlov, Ihor; Ilday, F. Omer; Gulseren, Oguz

    We report a new dynamical self-assembly mechanism, where judicious use of convective and strong Brownian forces enables effective patterning of colloidal nanoparticles that are almost two orders of magnitude smaller than the laser beam. Optical trapping or tweezing effects are not involved, but the laser is used to create steep thermal gradients through multi-photon absorption, and thereby guide the colloids through convective forces. Convective forces can be thought as a positive feedback mechanism that helps to form and reinforce pattern, while Brownian motion act as a competing negative feedback mechanism to limit the growth of the pattern, as well as to increase the possibilities of bifurcation into different patterns, analogous to the competition observed in reaction-diffusion systems. By steering stochastic processes through these forces, we are able to gain control over the emergent pattern such as to form-deform-reform of a pattern, to change its shape and transport it spatially within seconds. This enables us to dynamically initiate and control large patterns comprised of hundreds of colloids. Further, by not relying on any specific chemical, optical or magnetic interaction, this new method is, in principle, completely independent of the material type being assembled.

  13. Dynamics and regulation at the tip : a high resolution view on microtubele assembly

    NARCIS (Netherlands)

    Munteanu, Laura

    2008-01-01

    Microtubules are highly dynamic protein polymers that and are essential for intracellular organization and fundamental processes like transport and cell division. In cells, a wide family of microtubule-associated proteins (MAPs) tightly regulates microtubule dynamics. The work presented in this

  14. Parallel processing for nonlinear dynamics simulations of structures including rotating bladed-disk assemblies

    Science.gov (United States)

    Hsieh, Shang-Hsien

    1993-01-01

    The principal objective of this research is to develop, test, and implement coarse-grained, parallel-processing strategies for nonlinear dynamic simulations of practical structural problems. There are contributions to four main areas: finite element modeling and analysis of rotational dynamics, numerical algorithms for parallel nonlinear solutions, automatic partitioning techniques to effect load-balancing among processors, and an integrated parallel analysis system.

  15. Dynamic simulation for effective workforce management in new product development

    OpenAIRE

    M. Mutingi

    2012-01-01

    Effective planning and management of workforce for new product development (NPD) projects is a great challenge to many organisations, especially in the presence of engineering changes during the product development process. The management objective in effective workforce management is to recruit, develop and deploy the right people at the right place at the right time so as to fulfill organizational objectives. In this paper, we propose a dynamic simulation model to address the workforce mana...

  16. SACHET, Dynamic Fission Products Inventory in PWR Multiple Compartment System

    International Nuclear Information System (INIS)

    Kodaira, Hideki

    1990-01-01

    1 - Description of program or function: SACHET evaluates the dynamic fission product inventories in the multiple compartment system of pressurized water reactor (PWR) plants. 2 - Method of solution: SACHET utilizes a matrix of fission product core inventory which is previously calculated by the ORIGEN code. 3 - Restrictions on the complexity of the problem: Liquid wastes such as chemical waste and detergent waste are not included

  17. Dynamic simulation for effective workforce management in new product development

    Directory of Open Access Journals (Sweden)

    M. Mutingi

    2012-10-01

    Full Text Available Effective planning and management of workforce for new product development (NPD projects is a great challenge to many organisations, especially in the presence of engineering changes during the product development process. The management objective in effective workforce management is to recruit, develop and deploy the right people at the right place at the right time so as to fulfill organizational objectives. In this paper, we propose a dynamic simulation model to address the workforce management problem in a typical NPD project consisting of design, prototyping, and production phases. We assume that workforce demand is a function of project work remaining and the current available skill pool. System dynamics simulation concepts are used to capture the causality relationships and feedback loops in the workforce system from a systems thinking. The evaluation of system dynamics simulation reveals the dynamic behaviour in NPD workforce management systems and shows how adaptive dynamic recruitment and training decisions can effectively balance the workforce system during the NPD process.

  18. Plasma membrane is the site of productive HIV-1 particle assembly.

    Directory of Open Access Journals (Sweden)

    Nolwenn Jouvenet

    2006-12-01

    Full Text Available Recently proposed models that have gained wide acceptance posit that HIV-1 virion morphogenesis is initiated by targeting the major structural protein (Gag to late endosomal membranes. Thereafter, late endosome-based secretory pathways are thought to deliver Gag or assembled virions to the plasma membrane (PM and extracellular milieu. We present several findings that are inconsistent with this model. Specifically, we demonstrate that HIV-1 Gag is delivered to the PM, and virions are efficiently released into the extracellular medium, when late endosome motility is abolished. Furthermore, we show that HIV-1 virions are efficiently released when assembly is rationally targeted to the PM, but not when targeted to late endosomes. Recently synthesized Gag first accumulates and assembles at the PM, but a proportion is subsequently internalized via endocytosis or phagocytosis, thus accounting for observations of endosomal localization. We conclude that HIV-1 assembly is initiated and completed at the PM, and not at endosomal membranes.

  19. Dynamic Self-Assembly of Gold/Polymer Nanocomposites: pH-Encoded Switching between 1D Nanowires and 3D Nanosponges.

    Science.gov (United States)

    Zhang, Qi; Xu, Tian-Yi; Zhao, Cai-Xin; Jin, Wei-Hang; Wang, Qian; Qu, Da-Hui

    2017-10-05

    The design of tunable dynamic self-assembly of nanoparticles with switchable assembled dimensions and morphologies is a challenging goal whose realization is vital for the evolution of smart nanomaterials. Herein, we report on chitosan polymer as an effective supramolecular "glue" for aldehyde-modified Au nanoparticles to reversibly modulate the states of self-assembled nanocomposites. By simultaneous integration of dynamic covalent Schiff base interactions and noncovalent hydrogen bonds, the chitosan/Au nanocomposites could reversibly transform their assembled morphologies from one-dimensional nanowires to three-dimensional nanosponges in response to the variation of pH value. Moreover, the obtained nanosponges could be used as an efficient pH-controlled cargo release system. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Investment age and dynamic productivity growth in the Spanish food processing industry

    NARCIS (Netherlands)

    Kapelko, Magda; Oude Lansink, A.G.J.M.; Stefanou, S.E.

    2016-01-01

    This article analyzes the relation between investment age, measured as the number of years since investment spike, and dynamic productivity growth and its components, which include dynamic technical change, dynamic inefficiency change, and dynamic scale inefficiency change. The empirical application

  1. Technical products for radiation shielding. Shield assembled from lead blocks for radiation protection. General technical requirements

    International Nuclear Information System (INIS)

    1981-01-01

    The object of this standard description is the general technological requirements of 50 and 100 mm thick radiation protection shields assembled from lead blocks. The standard contains the definitions, types, parameters and dimensions of shields, their technical and acceptance criteria with testing methods, tagging, packaging, transportation and storage requirements, producer's liability. Some illustrated assembling examples, preferred parameters and dosimetry methods for shield inspection are given. (R.P.)

  2. ASPECTS OF REGIONAL COMPETITIVENESS THROUGH DYNAMIC PRICES OF PETROLEUM PRODUCTS

    Directory of Open Access Journals (Sweden)

    Daniela\tENACHESCU

    2015-06-01

    Full Text Available This paper presents aspects regarding the dynamics of prices of petroleum products: gasoline and diesel in Romania in the period 2003(2007-2014. Both focus on relationship-price raw material and finished product by the impact of market prices. Given that the price of fuel is a key factor in economic development but also in the living of population, this paper has proposed to analyze some aspects of the dynamics of prices of petroleum products in correlation with commodity prices in a competitive market in 2003 -2014. In the analized period, price of oil barrel has a dynamics substantially influenced by the global political turbulences but also by lower oil demand due to consumption reduction, especially lately. Increases and decreases were abrupt and unpredictable in the early years of the first decade of the XXI century. Political crises in the Middle East, the economic crisis started in 2007 and especially the crisis in Ukraine and policies adopted by the EU and the US have led to extremely large fluctuations in oil prices from one period to another . This dynamic will only cover the price of petroleum products namely gazoline and diesel for vehicles.

  3. Product quality driven design of bakery operations using dynamic optimization

    NARCIS (Netherlands)

    Hadiyanto, M.; Esveld, D.C.; Boom, R.M.; Straten, van G.; Boxtel, van A.J.B.

    2008-01-01

    Abstract Quality driven design uses specified product qualities as a starting point for process design. By backward reasoning the required process conditions and processing system were found. In this work dynamic optimization was used as a tool to generate processing solutions for baking processes

  4. Minimum entropy production principle from a dynamical fluctuation law

    Czech Academy of Sciences Publication Activity Database

    Maes, C.; Netočný, Karel

    2007-01-01

    Roč. 48, č. 5 (2007), 053306/1-053306/12 ISSN 0022-2488 R&D Projects: GA ČR GA202/07/0404 Institutional research plan: CEZ:AV0Z10100520 Keywords : dynamical fluctuations * entropy production Subject RIV: BE - Theoretical Physics Impact factor: 1.137, year: 2007

  5. Price and inventory dynamics in petroleum product markets

    International Nuclear Information System (INIS)

    Considine, T.J.; Heo, Eunnyeong

    2000-01-01

    Unlike many studies of commodity inventory behavior, this paper estimates a model with endogenous spot and forward prices, inventories, production, and net imports. Our application involves markets for refined petroleum products in the United States. Our model is built around the supply and demand for storage. We estimate the model using Generalized Method of Moments and perform dynamic, simultaneous simulations to estimate the impacts of supply and demand shocks. Supply curves for the industry are inelastic and upward sloping. High inventory levels depress prices. Inventories fall in response to higher sales, consistent with production smoothing. Under higher input prices, refiners reduce their stocks of crude oil but increase their product inventories, consistent with cost smoothing. In some cases, imports of products are more variable than production or inventories. 25 refs

  6. Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE

    OpenAIRE

    Hu, Zonglin; Gogol, Edward P.; Lutkenhaus, Joe

    2002-01-01

    Selection of the division site in Escherichia coli is regulated by the min system and requires the rapid oscillation of MinD between the two halves of the cell under the control of MinE. In this study we have further investigated the molecular basis for this oscillation by examining the interaction of MinD with phospholipid vesicles. We found that MinD bound to phospholipid vesicles in the presence of ATP and, upon binding, assembled into a well-ordered helical array that deformed the vesicle...

  7. Distributing flight dynamics products via the World Wide Web

    Science.gov (United States)

    Woodard, Mark; Matusow, David

    1996-01-01

    The NASA Flight Dynamics Products Center (FDPC), which make available selected operations products via the World Wide Web, is reported on. The FDPC can be accessed from any host machine connected to the Internet. It is a multi-mission service which provides Internet users with unrestricted access to the following standard products: antenna contact predictions; ground tracks; orbit ephemerides; mean and osculating orbital elements; earth sensor sun and moon interference predictions; space flight tracking data network summaries; and Shuttle transport system predictions. Several scientific data bases are available through the service.

  8. Assessment of assembly homogenized two-steps core dynamic calculations using direct whole core transport solutions

    International Nuclear Information System (INIS)

    Hursin, Mathieu; Downar, Thomas J.; Yoon, Joo Il; Joo, Han Gyu

    2016-01-01

    Highlights: • Reactivity initiated accident analysis with direct whole core transient transport code. • Comparison with usual “two steps” procedure. • Effect of effective delayed neutron fraction definition on energy deposition in the fuel. • Effect of homogenized few-group cross sections generation at the assembly level on energy deposition in the fuel. • Effect of effective fuel temperature definition on energy deposition in the fuel. - Abstract: The impact of the approximations in the “two-steps” procedure used in the current generation of nodal simulators for core transient calculations is assessed by using a higher order solution obtained from a direct, whole core, transient transport calculation. A control rod ejection accident in an idealized minicore is analyzed with PARCS, which uses the two-steps procedure and DeCART which provides the higher order solution. DeCART is used as lattice code to provide the homogenized cross sections and kinetics parameters to PARCS. The approximations made by using (1) the homogenized few-group cross sections and kinetic parameters generated at the assembly level, (2) an effective delayed neutrons fraction, (3) an effective fuel temperature and (4) the few-group formulation are investigated in terms of global and local core power behavior. The results presented in the paper show that the current two-steps procedure produces sufficiently accurate transient results with respect to the direct whole core calculation solution, provided that its parameters are carefully generated using the prescriptions described in the present article.

  9. Fuel-assembly behavior under dynamic impact loads due to dry-storage cask mishandling

    International Nuclear Information System (INIS)

    1991-07-01

    Continued operation of nuclear power plants is contingent on the ability to provide adequate storage of spent fuel. Until recently, utilities have been able to maintain interim in-pool spent fuel storage. However, many facilities have reached their capacity and are now faced with shipping their spent fuel in dry casks to alternate storage facilities. The objective of this report is to provide estimates of the structural integrity of irradiated LWR fuel rods subjected to impact loads resulting from postulated cask handling accidents. This is accomplished in five stages: (1) Material properties for irradiated fuel are compiled for use in the structural analyses. (2) Results from parametric analyses of representative assembly designs are used to determine the most limiting case for end and side drop postulated handling accidents. (3) Detailed structural analysis results are presented for these critical designs. The detailed analyses include the coupling of assembly interaction with the cask and cask internals. (4) Criteria for both ultimate stress and brittle fracture failure modes of fuel rod cladding are established. (5) Safe cask handling drop height limits are computed based on items 2 through 4 above. 44 figs., 18 tabs

  10. Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly and packaging occur concurrently at the periphery of the replication center.

    Directory of Open Access Journals (Sweden)

    Gabriela N Condezo

    2017-04-01

    Full Text Available Adenovirus (AdV morphogenesis is a complex process, many aspects of which remain unclear. In particular, it is not settled where in the nucleus assembly and packaging occur, and whether these processes occur in a sequential or a concerted manner. Here we use immunofluorescence and immunoelectron microscopy (immunoEM to trace packaging factors and structural proteins at late times post infection by either wildtype virus or a delayed packaging mutant. We show that representatives of all assembly factors are present in the previously recognized peripheral replicative zone, which therefore is the AdV assembly factory. Assembly intermediates and abortive products observed in this region favor a concurrent assembly and packaging model comprising two pathways, one for capsid proteins and another one for core components. Only when both pathways are coupled by correct interaction between packaging proteins and the genome is the viral particle produced. Decoupling generates accumulation of empty capsids and unpackaged cores.

  11. Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.

    Science.gov (United States)

    Kumar, Pramod; Satyam, Abhigyan; Fan, Xingliang; Collin, Estelle; Rochev, Yury; Rodriguez, Brian J; Gorelov, Alexander; Dillon, Simon; Joshi, Lokesh; Raghunath, Michael; Pandit, Abhay; Zeugolis, Dimitrios I

    2015-03-04

    Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly sophisticated supramolecular assemblies. However, in dilute ex vivo microenvironments, prolonged culture time is required to develop an extracellular matrix-rich implantable device. Herein, we assessed the influence of macromolecular crowding, a biophysical phenomenon that regulates intra- and extra-cellular activities in multicellular organisms, in human corneal fibroblast culture. In the presence of macromolecules, abundant extracellular matrix deposition was evidenced as fast as 48 h in culture, even at low serum concentration. Temperature responsive copolymers allowed the detachment of dense and cohesive supramolecularly assembled living substitutes within 6 days in culture. Morphological, histological, gene and protein analysis assays demonstrated maintenance of tissue-specific function. Macromolecular crowding opens new avenues for a more rational design in engineering of clinically relevant tissue modules in vitro.

  12. Folding and self-assembly of polypeptides: Dynamics and thermodynamics from molecular simulation

    Science.gov (United States)

    Fluitt, Aaron Michael

    Empowered by their exquisite three-dimensional structures, or "folds," proteins carry out biological tasks with high specificity, efficiency, and fidelity. The fold that optimizes biological function represents a stable configuration of the constituent polypeptide molecule(s) under physiological conditions. Proteins and polypeptides are not static, however: battered by thermal motion, they explore a distribution of folds that is determined by the sequence of amino acids, the presence and identity of other molecules, and the thermodynamic conditions. In this dissertation, we apply molecular simulation techniques to the study of two polypeptides that have unusually diffuse distributions of folds under physiological conditions: polyglutamine (polyQ) and islet amyloid polypeptide (IAPP). Neither polyQ nor IAPP adopts a predominant fold in dilute aqueous solution, but at sufficient concentrations, both are prone to self-assemble into stable, periodic, and highly regular aggregate structures known as amyloid. The appearance of amyloid deposits of polyQ in the brain, and of IAPP in the pancreas, are associated with Huntington's disease and type 2 diabetes, respectively. A molecular view of the mechanism(s) by which polyQ and IAPP fold and self-assemble will enhance our understanding of disease pathogenesis, and it has the potential to accelerate the development of therapeutics that target early-stage aggregates. Using molecular simulations with spatial and temporal resolution on the atomic scale, we present analyses of the structural distributions of polyQ and IAPP under various conditions, both in and out of equilibrium. In particular, we examine amyloid fibers of polyQ, the IAPP dimer in solution, and single IAPP fragments at a lipid bilayer. We also benchmark the molecular models, or "force fields," available for such studies, and we introduce a novel simulation algorithm.

  13. The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system.

    Science.gov (United States)

    Gu, Shuang; Shevchik, Vladimir E; Shaw, Rosie; Pickersgill, Richard W; Garnett, James A

    2017-10-01

    Many Gram-negative commensal and pathogenic bacteria use a type II secretion system (T2SS) to transport proteins out of the cell. These exported proteins or substrates play a major role in toxin delivery, maintaining biofilms, replication in the host and subversion of host immune responses to infection. We review the current structural and functional work on this system and argue that intrinsically disordered regions and protein dynamics are central for assembly, exo-protein recognition, and secretion competence of the T2SS. The central role of intrinsic disorder-order transitions in these processes may be a particular feature of type II secretion. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Insight of Transmembrane Processes of Self-Assembling Nanotubes Based on a Cyclic Peptide Using Coarse Grained Molecular Dynamics Simulation.

    Science.gov (United States)

    Fu, Yankai; Yan, Tingxuan; Xu, Xia

    2017-09-28

    Transmembrane self-assembling cyclic peptide (SCP) nanotubes are promising candidates for delivering specific molecules through cell membranes. The detailed mechanisms behind the transmembrane processes, as well as stabilization factors of transmembrane structures, are difficult to elucidate through experiments. In this study, the effects of peptide sequence and oligomeric state on the transmembrane capabilities of SCP nanotubes and the perturbation of embedded SCP nanotubes acting on the membrane were investigated based on coarse grained molecular dynamics simulation. The simulation results reveal that hydrophilic SCP oligomers result in the elevation of the energy barrier while the oligomerization of hydrophobic SCPs causes the reduction of the energy barrier, further leading to membrane insertion. Once SCP nanotubes are embedded, membrane properties such as density, thickness, ordering state and lateral mobility are adjusted along the radial direction. This study provides insight into the transmembrane strategy of SCP nanotubes and sheds light on designing novel transport systems.

  15. Plasmas for environmental issues: from hydrogen production to 2D materials assembly

    Science.gov (United States)

    Tatarova, E.; Bundaleska, N.; Sarrette, J. Ph; Ferreira, C. M.

    2014-12-01

    It is well recognized at present that the unique, high energy density plasma environment provides suitable conditions to dissociate/atomize molecules in remediation systems, to convert waste and biomass into sustainable energy sources, to purify water, to assemble nanostructures, etc. The remarkable plasma potential is based on its ability to supply simultaneously high fluxes of charged particles, chemically active molecules, radicals (e.g. O, H, OH), heat, highly energetic photons (UV and extreme UV radiation), and strong electric fields in intrinsic sheath domains. Due to this complexity, low-temperature plasma science and engineering is a huge, highly interdisciplinary field that spans many research disciplines and applications across many areas of our daily life and industrial activities. For this reason, this review deals only with some selected aspects of low-temperature plasma applications for a clean and sustainable environment. It is not intended to be a comprehensive survey, but just to highlight some important works and achievements in specific areas. The selected issues demonstrate the diversity of plasma-based applications associated with clean and sustainable ambiance and also show the unity of the underlying science. Fundamental plasma phenomena/processes/features are the common fibers that pass across all these areas and unify all these applications. Browsing through different topics, we try to emphasize these phenomena/processes/features and their uniqueness in an attempt to build a general overview. The presented survey of recently published works demonstrates that plasma processes show a significant potential as a solution for waste/biomass-to-energy recovery problems. The reforming technologies based on non-thermal plasma treatment of hydrocarbons show promising prospects for the production of hydrogen as a future clean energy carrier. It is also shown that plasmas can provide numerous agents that influence biological activity. The simultaneous

  16. Speech production in people who stutter: Testing the motor plan assembly hypothesis

    NARCIS (Netherlands)

    Lieshout, P.H.H.M. van; Hulstijn, W.; Peters, H.F.M.

    1996-01-01

    The main purpose of the present study was to test the hypothesis that persons who stutter, when compared to persons who do not stutter, are less able to assemble abstract motor plans for short verbal responses. Subjects were adult males who stutter and age- and sex-matched control speakers, who were

  17. Optimization of the recombinant production and purification of a self-assembling peptide in Escherichia coli

    NARCIS (Netherlands)

    Rad-Malekshahi, Mazda; Flement, Matthias; Hennink, Wim E.; Mastrobattista, Enrico

    2014-01-01

    Background: Amphiphilic peptides are important building blocks to generate nanostructured biomaterials for drug delivery and tissue engineering applications. We have shown that the self-assembling peptide SA2 (Ac-AAVVLLLWEE) can be recombinantly produced in E. coli when fused to the small

  18. Amphiphilic copolymers based on polyoxazoline and grape seed vegetable oil derivatives: self-assemblies and dynamic light scattering

    Energy Technology Data Exchange (ETDEWEB)

    Travelet, Christophe, E-mail: Christophe.Travelet@cermav.cnrs.fr [Universite Joseph Fourier (UJF), Institut de Chimie Moleculaire de Grenoble (ICMG-FR 2607 CNRS), PolyNat Carnot institute, Arcane LabEx, domaine universitaire de Grenoble, Centre de Recherches sur les Macromolecules Vegetales - CERMAV-UPR 5301 CNRS (France); Stemmelen, Mylene; Lapinte, Vincent [Universite de Montpellier II, Institut Charles Gerhardt Montpellier (UMR 5253 CNRS-UM2-UM1-ENSCM), equipe ingenierie et architectures macromoleculaires (France); Dubreuil, Frederic [Universite Joseph Fourier (UJF), Institut de Chimie Moleculaire de Grenoble (ICMG-FR 2607 CNRS), PolyNat Carnot institute, Arcane LabEx, domaine universitaire de Grenoble, Centre de Recherches sur les Macromolecules Vegetales - CERMAV-UPR 5301 CNRS (France); Robin, Jean-Jacques [Universite de Montpellier II, Institut Charles Gerhardt Montpellier (UMR 5253 CNRS-UM2-UM1-ENSCM), equipe ingenierie et architectures macromoleculaires (France); and others

    2013-06-15

    The self-assembly in solution of original structures of amphiphilic partially natural copolymers based on polyoxazoline [more precisely poly(2-methyl-2-oxazoline) (POx)] and grape seed vegetable oil derivatives (linear, T-, and trident-structure) is investigated. The results show that such systems are found, using dynamic light scattering (DLS), to spontaneously self-organize into monomodal, narrow-size, and stable nanoparticles in aqueous medium. The obtained hydrodynamic diameters (D{sub h}) range from 8.6 to 32.5 nm. Specifically, such size increases strongly with increasing natural block (i.e., lipophilic species) length due to higher hydrophobic interactions (from 10.1 nm for C{sub 19} to 19.2 nm for C{sub 57}). Furthermore, increasing the polyoxazoline (i.e., hydrophilic block) length leads to a moderate linear increase of the D{sub h}-values. Therefore, the first-order size effect comes from the natural lipophilic block, whereas the characteristic size can be tuned more finely (i.e., in a second-order) by choosing appropriately the polyoxazoline length. The DLS results in terms of characteristic size are corroborated using nanoparticle tracking analysis (NTA), and also by atomic force microscopy (AFM) and transmission electron microscopy (TEM) imaging where well-defined spherical and individual nanoparticles exhibit a very good mechanical resistance upon drying. Moreover, changing the lipophilic block architecture from linear to T-shape, while keeping the same molar mass, generates a branching and thus a shrinking by a factor of 2 of the nanoparticle volume, as observed by DLS. In this paper, it is clearly shown that the self-assemblies of amphiphilic block copolymer obtained from grape seed vegetable oil derivatives (sustainable renewable resources) as well as their tunability are of great interest for biomass valorization at the nanoscale level [continuation of the article by Stemmelen et al. (Polym Chem 4:1445-1458, 2013)].Graphical Abstract

  19. Amphiphilic copolymers based on polyoxazoline and grape seed vegetable oil derivatives: self-assemblies and dynamic light scattering

    International Nuclear Information System (INIS)

    Travelet, Christophe; Stemmelen, Mylène; Lapinte, Vincent; Dubreuil, Frédéric; Robin, Jean-Jacques

    2013-01-01

    The self-assembly in solution of original structures of amphiphilic partially natural copolymers based on polyoxazoline [more precisely poly(2-methyl-2-oxazoline) (POx)] and grape seed vegetable oil derivatives (linear, T-, and trident-structure) is investigated. The results show that such systems are found, using dynamic light scattering (DLS), to spontaneously self-organize into monomodal, narrow-size, and stable nanoparticles in aqueous medium. The obtained hydrodynamic diameters (D h ) range from 8.6 to 32.5 nm. Specifically, such size increases strongly with increasing natural block (i.e., lipophilic species) length due to higher hydrophobic interactions (from 10.1 nm for C 19 to 19.2 nm for C 57 ). Furthermore, increasing the polyoxazoline (i.e., hydrophilic block) length leads to a moderate linear increase of the D h -values. Therefore, the first-order size effect comes from the natural lipophilic block, whereas the characteristic size can be tuned more finely (i.e., in a second-order) by choosing appropriately the polyoxazoline length. The DLS results in terms of characteristic size are corroborated using nanoparticle tracking analysis (NTA), and also by atomic force microscopy (AFM) and transmission electron microscopy (TEM) imaging where well-defined spherical and individual nanoparticles exhibit a very good mechanical resistance upon drying. Moreover, changing the lipophilic block architecture from linear to T-shape, while keeping the same molar mass, generates a branching and thus a shrinking by a factor of 2 of the nanoparticle volume, as observed by DLS. In this paper, it is clearly shown that the self-assemblies of amphiphilic block copolymer obtained from grape seed vegetable oil derivatives (sustainable renewable resources) as well as their tunability are of great interest for biomass valorization at the nanoscale level [continuation of the article by Stemmelen et al. (Polym Chem 4:1445–1458, 2013)].Graphical AbstractAmphiphilic copolymers based

  20. Assembly Line Productivity Assessment by Comparing Optimization-Simulation Algorithms of Trajectory Planning for Industrial Robots

    Directory of Open Access Journals (Sweden)

    Francisco Rubio

    2015-01-01

    Full Text Available In this paper an analysis of productivity will be carried out from the resolution of the problem of trajectory planning of industrial robots. The analysis entails economic considerations, thus overcoming some limitations of the existing literature. Two methodologies based on optimization-simulation procedures are compared to calculate the time needed to perform an industrial robot task. The simulation methodology relies on the use of robotics and automation software called GRASP. The optimization methodology developed in this work is based on the kinematics and the dynamics of industrial robots. It allows us to pose a multiobjective optimization problem to assess the trade-offs between the economic variables by means of the Pareto fronts. The comparison is carried out for different examples and from a multidisciplinary point of view, thus, to determine the impact of using each method. Results have shown the opportunity costs of non using the methodology with optimized time trajectories. Furthermore, it allows companies to stay competitive because of the quick adaptation to rapidly changing markets.

  1. Exploring the Dynamics of Responses to Food Production Shocks

    Directory of Open Access Journals (Sweden)

    Aled Jones

    2017-06-01

    Full Text Available Food production shocks can lead to food crises where access to appropriate quantities and quality of food become inadequate, unaffordable, or unreliable on a major scale. While the physical causes of food production shocks are well researched, the dynamics of responses to them are less well understood. This paper reviews those dynamics and includes evidence gathered via interviews of 44 expert practitioners sourced globally from academia, government, industry, think-tanks, and development/relief organizations. The paper confirms that policy interventions are often prioritised for national interests and poorly coordinated at regional and global scales. The paper acknowledges future compounding trends such as climate change and demographic shifts and suggests that while there are signs of incremental progress in better managing the impacts of shock events, coordinated responses at scale will require a paradigm shift involving major policy, market, and technological advancements, and a wide range of public and private sector stakeholders.

  2. Dynamic Pricing Competition with Strategic Customers Under Vertical Product Differentiation

    OpenAIRE

    Qian Liu; Dan Zhang

    2013-01-01

    We consider dynamic pricing competition between two firms offering vertically differentiated products to strategic customers who are intertemporal utility maximizers. We show that price skimming arises as the unique pure-strategy Markov perfect equilibrium in the game under a simple condition. Our results highlight the asymmetric effect of strategic customer behavior on quality-differentiated firms. Even though the profit of either firm decreases as customers become more strategic, the low-qu...

  3. Dynamic strategic responses among advertisers: the case of meat products

    OpenAIRE

    Jeffrey Hyde; Brent Gloy

    2007-01-01

    The case of strategic advertising response is examined for branded and generic meat products (beef, pork, and poultry). A dynamic conceptual model is developed to identify the determinants of advertising expenditures. A time-series model is then used to examine the competitive behavior of branded and generic meat advertisers. The results identify two types of advertising strategies those based upon changes in revenues and those based upon changes in competitor advertising expenditures. Most g...

  4. Dynamical coupled channel approach to omega meson production

    Energy Technology Data Exchange (ETDEWEB)

    Mark Paris

    2007-09-10

    The dynamical coupled channel approach of Matsuyama, Sato, and Lee is used to study the $\\omega$--meson production induced by pions and photons scattering from the proton. The parameters of the model are fixed in a two-channel (\\omega N,\\pi N) calculation for the non-resonant and resonant contributions to the $T$ matrix by fitting the available unpolarized differential cross section data. The polarized photon beam asymmetry is predicted and compared to existing data.

  5. Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

    Directory of Open Access Journals (Sweden)

    Hiroki Oguri

    2012-06-01

    Full Text Available By emulating the universal biosynthetic strategy, which employs modular assembly and divergent cyclizations, we have developed a four-step synthetic process to yield a collection of natural-product-inspired scaffolds. Modular assembly of building blocks onto a piperidine-based manifold 6, having a carboxylic acid group, was achieved through Ugi condensation, N-acetoacetylation and diazotransfer, leading to cyclization precursors. The rhodium-catalyzed tandem cyclization and divergent cycloaddition gave rise to tetracyclic and hexacyclic scaffolds by the appropriate choice of dipolarophiles installed at modules 3 and 4. A different piperidine-based manifold 15 bearing an amino group was successfully applied to demonstrate the flexibility and scope of the unified four-step process for the generation of structural diversity in the fused scaffolds. Evaluation of in vitro antitrypanosomal activities of the collections and preliminary structure–activity relationship (SAR studies were also undertaken.

  6. The application of dynamic programming in production planning

    Science.gov (United States)

    Wu, Run

    2017-05-01

    Nowadays, with the popularity of the computers, various industries and fields are widely applying computer information technology, which brings about huge demand for a variety of application software. In order to develop software meeting various needs with most economical cost and best quality, programmers must design efficient algorithms. A superior algorithm can not only soul up one thing, but also maximize the benefits and generate the smallest overhead. As one of the common algorithms, dynamic programming algorithms are used to solving problems with some sort of optimal properties. When solving problems with a large amount of sub-problems that needs repetitive calculations, the ordinary sub-recursive method requires to consume exponential time, and dynamic programming algorithm can reduce the time complexity of the algorithm to the polynomial level, according to which we can conclude that dynamic programming algorithm is a very efficient compared to other algorithms reducing the computational complexity and enriching the computational results. In this paper, we expound the concept, basic elements, properties, core, solving steps and difficulties of the dynamic programming algorithm besides, establish the dynamic programming model of the production planning problem.

  7. Static and dynamic analysis of beam assemblies using a differential system on an oriented graph

    Czech Academy of Sciences Publication Activity Database

    Náprstek, Jiří; Fischer, Cyril

    2015-01-01

    Roč. 155, July (2015), s. 28-41 ISSN 0045-7949 R&D Projects: GA ČR(CZ) GA15-01035S Institutional support: RVO:68378297 Keywords : symmetric operators * oriented graph * dynamic stiffness matrix * slope deflection method * finite element method Subject RIV: JM - Building Engineering Impact factor: 2.425, year: 2015 http://www.sciencedirect.com/science/article/pii/S0045794915000590#

  8. The influence of interparticle correlations and self-assembly on the dynamic initial magnetic susceptibility spectra of ferrofluids

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, A.O., E-mail: alexey.ivanov@urfu.ru [Institute of Mathematics and Computer Sciences, Ural Federal University, Lenin Avenue 51, 620000 Ekaterinburg (Russian Federation); Kantorovich, S.S. [Institute of Mathematics and Computer Sciences, Ural Federal University, Lenin Avenue 51, 620000 Ekaterinburg (Russian Federation); Faculty of Physics, University of Vienna, Sensengasse 8, 1090 Vienna (Austria); Elfimova, E.A.; Zverev, V.S. [Institute of Mathematics and Computer Sciences, Ural Federal University, Lenin Avenue 51, 620000 Ekaterinburg (Russian Federation); Sindt, J.O. [School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, Scotland (United Kingdom); Camp, P.J. [Institute of Mathematics and Computer Sciences, Ural Federal University, Lenin Avenue 51, 620000 Ekaterinburg (Russian Federation); School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, Scotland (United Kingdom)

    2017-06-01

    Using computer simulations and a mean-field theoretical approach, we study how the growth in dipolar interparticle correlations manifests itself in the frequency-dependent initial magnetic susceptibility of a ferrofluid. Our recently developed theory gives the correct single-particle Debye-theory results in the low-concentration, non-interacting regime; and it yields the exact leading-order contributions from interparticle correlations. The susceptibility spectra are analysed in terms of the low-frequency behaviours of the real and imaginary parts, and the position of the peak in the imaginary part. By comparing the theoretical predictions to the results from Brownian dynamics simulations, it is possible to identify the conditions where correlations are important, but where self-assembly has not developed. We also provide a qualitative explanation for the behaviour of spectra beyond the mean-field limit. - Highlights: • The interparticle interaction influences the dynamic susceptibility spectra of magnetic fluids. • The imaginary part maximum shifts to lower frequencies due to the dipolar interparticle interaction. • Chain formation should influence the susceptibility spectrum by shifting the absorption peak to lower frequencies.

  9. The influence of interparticle correlations and self-assembly on the dynamic initial magnetic susceptibility spectra of ferrofluids

    International Nuclear Information System (INIS)

    Ivanov, A.O.; Kantorovich, S.S.; Elfimova, E.A.; Zverev, V.S.; Sindt, J.O.; Camp, P.J.

    2017-01-01

    Using computer simulations and a mean-field theoretical approach, we study how the growth in dipolar interparticle correlations manifests itself in the frequency-dependent initial magnetic susceptibility of a ferrofluid. Our recently developed theory gives the correct single-particle Debye-theory results in the low-concentration, non-interacting regime; and it yields the exact leading-order contributions from interparticle correlations. The susceptibility spectra are analysed in terms of the low-frequency behaviours of the real and imaginary parts, and the position of the peak in the imaginary part. By comparing the theoretical predictions to the results from Brownian dynamics simulations, it is possible to identify the conditions where correlations are important, but where self-assembly has not developed. We also provide a qualitative explanation for the behaviour of spectra beyond the mean-field limit. - Highlights: • The interparticle interaction influences the dynamic susceptibility spectra of magnetic fluids. • The imaginary part maximum shifts to lower frequencies due to the dipolar interparticle interaction. • Chain formation should influence the susceptibility spectrum by shifting the absorption peak to lower frequencies.

  10. Investigation of the dynamic behavior of the ITER tokamak assembly using a 1/5.8-scale model

    Energy Technology Data Exchange (ETDEWEB)

    Onozuka, M. [Mitsubishi Heavy Industries, Ltd., Nuclear Systems Engineering Department, Konan 2-16-5, Minato-ku, Tokyo 108-8215 (Japan)]. E-mail: masanori_onozuka@mhi.co.jp; Shimizu, K. [Mitsubishi Heavy Industries, Ltd., Nuclear Systems Engineering Department, Konan 2-16-5, Minato-ku, Tokyo 108-8215 (Japan); Nakamura, T. [Mitsubishi Heavy Industries, Ltd., Nuclear Systems Engineering Department, Konan 2-16-5, Minato-ku, Tokyo 108-8215 (Japan); Takeda, N. [Japan Atomic Energy Research Institute, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan); Nakahira, M. [Japan Atomic Energy Research Institute, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan); Tado, S. [Japan Atomic Energy Research Institute, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan); Shibanuma, K. [Japan Atomic Energy Research Institute, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan)

    2006-02-15

    The dynamic behavior of the ITER tokamak assembly has been investigated, using a 1/5.8-scale model. In the static load test, the observed deformations and stresses were confirmed to be linearly proportional to the applied loads. In the vibration test, the first and third eigen-modes corresponded to horizontal vibration modes, with natural frequencies of about 29 and 81 Hz, respectively. The global-twisting and oval modes were found to be in the second and forth modes, with frequencies of about 60 and 86 Hz, respectively. A comparison of experimental and analytical results showed that the deflections and the induced stresses in the analysis were approximately half of those found in the experiment. Natural frequencies have also been compared. The frequency in the first mode was almost the same for both the experiment and the analysis. However, in higher vibration modes, the natural frequencies in the experiment were found to be smaller than those in the analysis. To further examine the dynamic behavior of the coil structure, a vibration test of the entire sub-scale model is planned using the vibration stage rather than the shaker.

  11. Developing a capillary electrophoresis based method for dynamically monitoring enzyme cleavage activity using quantum dots-peptide assembly.

    Science.gov (United States)

    Wang, Jianhao; Fan, Jie; Liu, Li; Ding, Shumin; Liu, Xiaoqian; Wang, Jianpeng; Gao, Liqian; Chattopadhaya, Souvik; Miao, Peng; Xia, Jiang; Qiu, Lin; Jiang, Pengju

    2017-10-01

    Herein, a novel assay has been developed for monitoring PreScission protease (His-PSP) mediated enzyme cleavage of ATTO 590 labeled peptide substrate (ATTO-LEV). This novel method is based on combining the use of capillary electrophoresis and fluorescence detection (CE-FL) to dynamically monitor the enzyme cleavage activity. A multivalent peptide substrate was first constructed by immobilizing His-tagged ATTO 590 labeled peptide substrate (ATTO-LEVH6) onto the surface of CdSe/ZnS quantum dots (QDs). Once successfully immobilized, the novel multivalent peptide substrate resulted in the Förster resonance energy transfer (FRET) from QDs to ATTO 590. The ATTO-LEVH6-QD assembly was then incubated with His-PSP to study the proteolytic cleavage of surface bound ATTO-LEVH6 by CE-FL. Our data suggests that PreScission-mediated proteolytic cleavage is enzyme concentration- and incubation time-dependent. By combining capillary electrophoresis, QDs and FRET, our study herein not only provides a new method for the detection and dynamically monitoring of PSP enzyme cleavage activity, but also can be extended to the detection of many other enzymes and proteases. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Defining Determinants and Dynamics and Cellulose Microfibril Biosynthesis, Assembly and Degredation OSP Number: 63079/A001

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2013-12-01

    The central paradigm for converting plant biomass into soluble sugars for subsequent conversion to transportation fuels involves the enzymatic depolymerization of lignocellulosic plant cell walls by microbial enzymes. Despite decades of intensive research, this is still a relatively inefficient process, due largely to the recalcitrance and enormous complexity of the substrate. A major obstacle is still insufficient understanding of the detailed structure and biosynthesis of major wall components, including cellulose. For example, although cellulose is generally depicted as rigid, insoluble, uniformly crystalline microfibrils that are resistant to enzymatic degradation, the in vivo structures of plant cellulose microfibrils are surprisingly complex. Crystallinity is frequently disrupted, for example by dislocations and areas containing chain ends, resulting in “amorphous” disordered regions. Importantly, microfibril structure and the relative proportions of crystalline and non-crystalline disordered surface regions vary substantially and yet the molecular mechanisms by which plants regulate microfibril crystallinity, and other aspects of microfibril architecture, are still entirely unknown. This obviously has a profound effect on susceptibility to enzymatic hydrolysis and so this is a critical area of research in order to characterize and optimize cellulosic biomass degradation. The entire field of cell wall assembly, as distinct from polysaccharide biosynthesis, and the degree to which they are coupled, are relatively unexplored, despite the great potential for major advances in addressing the hurdle of biomass recalcitrance. Our overarching hypothesis was that identification of the molecular machinery that determine microfibril polymerization, deposition and structure will allow the design of more effective degradative systems, and the generation of cellulosic materials with enhanced and predictable bioconversion characteristics. Our experimental framework had

  13. Magnetic properties of novel dynamic self-assembled structures generated on the liquid/air interface

    International Nuclear Information System (INIS)

    Snezhko, A.; Aranson, I.S.

    2007-01-01

    We report on experimental and theoretical studies of magnetic properties of recently discovered dynamic multi-segment self-organized structures ('magnetic snakes'). Magnetic order and response of such snakes are determined by a novel unconventional mechanism provided by a self-induced surface wave. It gives rise to a nontrivial magnetic order: the segments of the snake exhibit long-range antiferromagnetic order mediated by the surface waves, while each segment is composed of ferromagnetically aligned chains of microparticles. Magnetic properties of the snakes are probed by in-plane magnetic field. A phenomenological model is proposed to explain the experimental observations

  14. Investigation on musculoskeletal discomfort and ergonomics risk factors among production team members at an automotive component assembly plant

    Science.gov (United States)

    Aziz, Fazilah Abdul; Ghazalli, Zakri; Zuki Mohamed, Nik Mohd; Isfar, Amri

    2017-10-01

    Musculoskeletal discomfort (MSD) is very common condition in automotive industry. MSD is affecting the worker’s health, well-being and lower down the productivity. Therefore, the main objective of this study was to identify the prevalence of MSD and ergonomics risk factors among the production team members at a selected automotive component manufacturer in Malaysia. MSD data were collected by conducting structure interview with all participants by referring to the Cornell Musculoskeletal Disorder Questionnaire (CMDQ). Those production team members who achieved a total discomfort score for all body regions more than 100 was selected for job task assessment. The physical exposure risk factors of work related musculoskeletal disorders (WMSD) has evaluated by using Quick Exposure Check (QEC) techniques. The results of the study identified the severe MSD associated with production assembly team members. It is expected that the prevalence of MSD for those production assembly team members was lower back (75.4%), upper back (63.2%), right shoulder (61.4%), and right wrist (60%). The QEC analysis discovered that about 70% of job tasks had very high risks for neck posture and 60% had high risks for the back (in moving condition) and shoulder/arm postures. There were 80% of respondents have produced a high score for exposure risk to vibration. As a conclusion, the main implication of the current study is that special attention should be paid to the physical and psychosocial aspects in production team members with musculoskeletal discomfort to improve their safety, health, and well-being, maintain work ability and productivity.

  15. Relational dynamics in the multi-helices knowledge production system

    DEFF Research Database (Denmark)

    Thai, Thi Minh; Hjortsø, Carsten Nico Portefée

    -level dynamics are characterized by political ambidexterity that enables the state to maintain control by privileging traditional science and education constituencies, and at the same time support the transition of the knowledge production system towards international methodology and quality standards through......Drawing on the triple helix framework and organizational institutionalism, this article applies a qualitative research approach to analyze structures, institutional logics, power relations that shape inter-organizational relations and the structuration of a knowledge production system...... in an emerging economy. Findings highlight the emergence of a fifth-helices knowledge production system includes the state, science and education, industry, international actors, and society. The system comprises two major segments, one associated with the traditional command economy and characterized...

  16. Characterization of transcriptome dynamics during watermelon fruit development: sequencing, assembly, annotation and gene expression profiles.

    Science.gov (United States)

    Guo, Shaogui; Liu, Jingan; Zheng, Yi; Huang, Mingyun; Zhang, Haiying; Gong, Guoyi; He, Hongju; Ren, Yi; Zhong, Silin; Fei, Zhangjun; Xu, Yong

    2011-09-21

    Cultivated watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai var. lanatus] is an important agriculture crop world-wide. The fruit of watermelon undergoes distinct stages of development with dramatic changes in its size, color, sweetness, texture and aroma. In order to better understand the genetic and molecular basis of these changes and significantly expand the watermelon transcript catalog, we have selected four critical stages of watermelon fruit development and used Roche/454 next-generation sequencing technology to generate a large expressed sequence tag (EST) dataset and a comprehensive transcriptome profile for watermelon fruit flesh tissues. We performed half Roche/454 GS-FLX run for each of the four watermelon fruit developmental stages (immature white, white-pink flesh, red flesh and over-ripe) and obtained 577,023 high quality ESTs with an average length of 302.8 bp. De novo assembly of these ESTs together with 11,786 watermelon ESTs collected from GenBank produced 75,068 unigenes with a total length of approximately 31.8 Mb. Overall 54.9% of the unigenes showed significant similarities to known sequences in GenBank non-redundant (nr) protein database and around two-thirds of them matched proteins of cucumber, the most closely-related species with a sequenced genome. The unigenes were further assigned with gene ontology (GO) terms and mapped to biochemical pathways. More than 5,000 SSRs were identified from the EST collection. Furthermore we carried out digital gene expression analysis of these ESTs and identified 3,023 genes that were differentially expressed during watermelon fruit development and ripening, which provided novel insights into watermelon fruit biology and a comprehensive resource of candidate genes for future functional analysis. We then generated profiles of several interesting metabolites that are important to fruit quality including pigmentation and sweetness. Integrative analysis of metabolite and digital gene expression

  17. Spontaneous assembly of HSP90 inhibitors at water/octanol interface: A molecular dynamics simulation study

    Science.gov (United States)

    Zolghadr, Amin Reza; Boroomand, Samaneh

    2017-02-01

    Drug absorption at an acceptable dose depends on the pair of solubility and permeability. There are many potent therapeutics that are not active in vivo, presumably due to the lack of capability to cross the cell membrane. Molecular dynamics simulation of radicicol, diol-radicicol, cyclopropane-radicicol and 17-DMAG were performed at water/octanol interface to suggest interfacial activity as a physico-chemical characteristic of these heat shock protein 90 (HSP90) inhibitors. We have observed that orally active HSP90 inhibitors form aggregates at the water/octanol and DPPC-lipid/water interfaces by starting from an initial configuration with HSP90 inhibitors embedded in the water matrix.

  18. Recovery after mass extinction: evolutionary assembly in large-scale biosphere dynamics.

    Science.gov (United States)

    Solé, Ricard V; Montoya, José M; Erwin, Douglas H

    2002-01-01

    Biotic recoveries following mass extinctions are characterized by a process in which whole ecologies are reconstructed from low-diversity systems, often characterized by opportunistic groups. The recovery process provides an unexpected window to ecosystem dynamics. In many aspects, recovery is very similar to ecological succession, but important differences are also apparently linked to the innovative patterns of niche construction observed in the fossil record. In this paper, we analyse the similarities and differences between ecological succession and evolutionary recovery to provide a preliminary ecological theory of recoveries. A simple evolutionary model with three trophic levels is presented, and its properties (closely resembling those observed in the fossil record) are compared with characteristic patterns of ecological response to disturbances in continuous models of three-level ecosystems. PMID:12079530

  19. INSURANCE OF KNITTED PRODUCTS QUALITY THROUGH THE ANALYSIS AND EVALUATION OF NON-QUALITY DURING ASSEMBLY BY STITCHING

    Directory of Open Access Journals (Sweden)

    LUTIC Liliana

    2014-05-01

    Full Text Available In a knitting factory, any activity oriented toward evaluation, maintenance or improvement of products quality level is based on measuring and examining the product quality characteristics, in order to establish conformity to the quality specifications and/or naming the non-quality characteristics, thus noticing defects or fabrication deficiencies. The quality of the stitching operation has a particular influence on the finite product quality and is determined on side by the quality of knitted pieces, and on the other by insuring the correlation between the technological parameters of the stitching operation and the physico-mechanical characteristics of the knittings that are to be assembled through stitching. Although the product execution processes comprise of manufacturing the elements and distinct subassemblies and their ulterior assembly, they present various difference dictated by the constructive particularities of the machine, as well as fabric characteristics. Because of the multiple interactions between the material, yarn and working parts of the sawing machine, inadequacies in the technological discipline can result in negative effects on both the knitted and stitching thread as well as the machine. A part of these can be fixed by extra time consuming tasks (yarn breaks, stitching ruffling etc., while other defects appear during the usage of the product cheapening it (stitch tearing by perforating the knitted on the stitching line, pilling effect, dimensional instability etc.. This paper systematically presents, the main defects that may occur during the stitching operation of the products made out of circular knitted, as well as the causes that generate them along with preventive or corrective actions.

  20. Entropy equilibrium equation and dynamic entropy production in environment liquid

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The entropy equilibrium equation is the basis of the nonequilibrium state thermodynamics. But the internal energy implies the kinetic energy of the fluid micelle relative to mass center in the classical entropy equilibrium equation at present. This internal energy is not the mean kinetic energy of molecular movement in thermodynamics. Here a modified entropy equilibrium equation is deduced, based on the concept that the internal energy is just the mean kinetic energy of the molecular movement. A dynamic entropy production is introduced into the entropy equilibrium equation to describe the dynamic process distinctly. This modified entropy equilibrium equation can describe not only the entropy variation of the irreversible processes but also the reversible processes in a thermodynamic system. It is more reasonable and suitable for wider applications.

  1. Dynamic Simulation and Optimization of Nuclear Hydrogen Production Systems

    Energy Technology Data Exchange (ETDEWEB)

    Paul I. Barton; Mujid S. Kaximi; Georgios Bollas; Patricio Ramirez Munoz

    2009-07-31

    This project is part of a research effort to design a hydrogen plant and its interface with a nuclear reactor. This project developed a dynamic modeling, simulation and optimization environment for nuclear hydrogen production systems. A hybrid discrete/continuous model captures both the continuous dynamics of the nuclear plant, the hydrogen plant, and their interface, along with discrete events such as major upsets. This hybrid model makes us of accurate thermodynamic sub-models for the description of phase and reaction equilibria in the thermochemical reactor. Use of the detailed thermodynamic models will allow researchers to examine the process in detail and have confidence in the accurary of the property package they use.

  2. De novo transcriptome assembly associated with fumonisin production by the rice pathogen Fusarium fujikuroi

    Directory of Open Access Journals (Sweden)

    Keerthi S. Guruge

    2018-06-01

    Full Text Available The present study employed a next-generation sequencing method to assemble a de novo transcriptome database designed to distinguish gene expression changes exhibited by the fumonisin-producing fungus Fusarium fujikuroi when grown under ‘fumonisin-producing’ compared to ‘non-fumonisin-producing’ conditions. The raw data of this study have been deposited at DNA Data Bank of Japan (DDBJ under the accession ID DRA006146. Keywords: Fusarium fujikuroi, Fumonisin, Next-generation sequencing, Transcriptome, Gene-expression

  3. Molecular assembly and magnetic dynamics of two novel Dy6 and Dy8 aggregates.

    Science.gov (United States)

    Guo, Yun-Nan; Chen, Xiao-Hua; Xue, Shufang; Tang, Jinkui

    2012-04-02

    Complexation of dysprosium(III) with the heterodonor chelating ligand o-vanillin picolinoylhydrazone (H(2)ovph) in the presence of a carbonato ligand affords two novel Dy(6) and Dy(8) clusters, namely, [Dy(6)(ovph)(4)(Hpvph)(2)Cl(4)(H(2)O)(2)(CO(3))(2)]·CH(3)OH·H(2)O·CH(3)CN (2) and [Dy(8)(ovph)(8)(CO(3))(4)(H(2)O)(8)]·12CH(3)CN·6H(2)O (3). Compound 2 is composed of three petals of the Dy(2) units linked by two carbonato ligands, forming a triangular prism arrangement, while compound 3 possesses an octanuclear core with an unprecedented tub conformation, in which Dy(ovph) fragments are attached to the sides of the carbonato core. The static and dynamic magnetic properties are reported and discussed. In the Dy(6) aggregate, three Dy(2) "skeletons", having been well preserved (see the scheme), contribute to the single-molecule-magnet behavior with a relatively slow tunneling rate, while the Dy(8) cluster only exhibits a rather small relaxation barrier.

  4. Vibrational dynamics of icosahedrally symmetric biomolecular assemblies compared with predictions based on continuum elasticity.

    Science.gov (United States)

    Yang, Zheng; Bahar, Ivet; Widom, Michael

    2009-06-03

    Coarse-grained elastic network models elucidate the fluctuation dynamics of proteins around their native conformations. Low-frequency collective motions derived by simplified normal mode analysis are usually involved in biological function, and these motions often possess noteworthy symmetries related to the overall shape of the molecule. Here, insights into these motions and their frequencies are sought by considering continuum models with appropriate symmetry and boundary conditions to approximately represent the true atomistic molecular structure. We solve the elastic wave equations analytically for the case of spherical symmetry, yielding a symmetry-based classification of molecular motions together with explicit predictions for their vibrational frequencies. We address the case of icosahedral symmetry as a perturbation to the spherical case. Applications to lumazine synthase, satellite tobacco mosaic virus, and brome mosaic virus show that the spherical elastic model efficiently provides insights on collective motions that are otherwise obtained by detailed elastic network models. A major utility of the continuum models is the possibility of estimating macroscopic material properties such as the Young's modulus or Poisson's ratio for different types of viruses.

  5. Dynamics of Singlet Fission and Electron Injection in Self-Assembled Acene Monolayers on Titanium Dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Justin C [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Pace, Natalie A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Arias, Dylan H [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Christensen, Steven T [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Granger, Devin B. [University of Kentucky; Anthony, John E. [University of Kentucky

    2018-02-26

    We employ a combination of linear spectroscopy, electrochemistry, and transient absorption spectroscopy to characterize the interplay between electron transfer and singlet fission dynamics in polyacene-based dyes attached to nanostructured TiO2. For triisopropyl silylethynyl (TIPS)-pentacene, we find that the singlet fission time constant increases to 6.5 ps on a nanostructured TiO2 surface relative to a thin film time constant of 150 fs, and that triplets do not dissociate after they are formed. In contrast, TIPS-tetracene singlets quickly dissociate in 2 ps at the molecule/TiO2 interface, and this dissociation outcompetes the relatively slow singlet fission process. The addition of an alumina layer slows down electron injection, allowing the formation of triplets from singlet fission in 40 ps. However, the triplets do not inject electrons, which is likely due to a lack of sufficient driving force for triplet dissociation. These results point to the critical balance required between efficient singlet fission and appropriate energetics for interfacial charge transfer.

  6. THERMAL DIAGNOSTICS WITH THE ATMOSPHERIC IMAGING ASSEMBLY ON BOARD THE SOLAR DYNAMICS OBSERVATORY: A VALIDATED METHOD FOR DIFFERENTIAL EMISSION MEASURE INVERSIONS

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Mark C. M.; Boerner, P.; Schrijver, C. J.; Malanushenko, A. [Lockheed Martin Solar and Astrophysics Laboratory, 3251 Hanover Street Bldg. 252, Palo Alto, CA 94304 (United States); Testa, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Chen, F.; Peter, H., E-mail: cheung@lmsal.com [Max Planck Institute for Solar System Research, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany)

    2015-07-10

    We present a new method for performing differential emission measure (DEM) inversions on narrow-band EUV images from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory. The method yields positive definite DEM solutions by solving a linear program. This method has been validated against a diverse set of thermal models of varying complexity and realism. These include (1) idealized Gaussian DEM distributions, (2) 3D models of NOAA Active Region 11158 comprising quasi-steady loop atmospheres in a nonlinear force-free field, and (3) thermodynamic models from a fully compressible, 3D MHD simulation of active region (AR) corona formation following magnetic flux emergence. We then present results from the application of the method to AIA observations of Active Region 11158, comparing the region's thermal structure on two successive solar rotations. Additionally, we show how the DEM inversion method can be adapted to simultaneously invert AIA and Hinode X-ray Telescope data, and how supplementing AIA data with the latter improves the inversion result. The speed of the method allows for routine production of DEM maps, thus facilitating science studies that require tracking of the thermal structure of the solar corona in time and space.

  7. Application of X-ray digital radiography to online automated inspection of interior assembly structures of complex products

    International Nuclear Information System (INIS)

    Han Yueping; Han Yan; Li Ruihong; Wang Liming

    2009-01-01

    The paper proposes an application of X-ray digital radiography to online automated inspection and recognition of the interior assembly structures of complex products by means of the multiple views techniques. First, a vertical hybrid projection function (VHPF) is proposed as the recognition feature of a two-dimensional image. VHPF combines an integral projection function and a standard deviation function so that it can reflect the mean and the variance of the pixels in the vertical direction in an image. Secondly, by considering the different importance grades of objects inside the product and the independence of these objects along the circumference, the paper presents a hierarchical recognition method and uses a neural network system to speed up the computation process with parallel operations. Thirdly, using the whole-orientation features of one standard swatch and by extracting its maximal system of linear independence as the feature basis, the issue of blind areas for recognition is resolved. Based on this approach, the first domestic X-ray multi-view digital detection system has been developed and applied to the online detection of objects containing complicated assembly structures.

  8. Enhancement of thermo-stability and product tolerance of Pseudomonas putida nitrile hydratase by fusing with self-assembling peptide.

    Science.gov (United States)

    Liu, Yi; Cui, Wenjing; Liu, Zhongmei; Cui, Youtian; Xia, Yuanyuan; Kobayashi, Michihiko; Zhou, Zhemin

    2014-09-01

    Self-assembling amphipathic peptides (SAPs) are the peptides that can spontaneously assemble into ordered nanostructures. It has been reported that the attachment of SAPs to the N- or C-terminus of an enzyme can benefit the thermo-stability of the enzyme. Here, we discovered that the thermo-stability and product tolerance of nitrile hydratase (NHase) were enhanced by fusing with two of the SAPs (EAK16 and ELK16). When the ELK16 was fused to the N-terminus of β-subunit, the resultant NHase (SAP-NHase-2) became an active inclusion body; EAK16 fused NHase in the N-terminus of β-subunit (SAP-NHase-1) and ELK16 fused NHase in the C-terminus of β-subunit (SAP-NHase-10) did not affect NHase solubility. Compared with the deactivation of the wild-type NHase after 30 min incubation at 50°C, SAP-NHase-1, SAP-NHase-2 and SAP-NHase-10 retained 45%, 30% and 50% activity; after treatment in the buffer containing 10% acrylamide, the wild-type retained 30% activity, while SAP-NHase-1, SAP-NHase-2 and SAP-NHase-10 retained 52%, 42% and 55% activity. These SAP-NHases with enhanced thermo-stability and product tolerance would be helpful for further industrial applications of the NHase. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  9. Work-related musculoskeletal disorders (WMDs) risk assessment at core assembly production of electronic components manufacturing company

    Science.gov (United States)

    Yahya, N. M.; Zahid, M. N. O.

    2018-03-01

    This study conducted to assess the work-related musculoskeletal disorders (WMDs) among the workers at core assembly production in an electronic components manufacturing company located in Pekan, Pahang, Malaysia. The study is to identify the WMDs risk factor and risk level. A set of questionnaires survey based on modified Nordic Musculoskeletal Disorder Questionnaires have been distributed to respective workers to acquire the WMDs risk factor identification. Then, postural analysis was conducted in order to measure the respective WMDs risk level. The analysis were based on two ergonomics assessment tools; Rapid Upper Limb Assessment (RULA) and Rapid Entire Body Assessment (REBA). The study found that 30 respondents out of 36 respondents suffered from WMDs especially at shoulder, wrists and lower back. The WMDs risk have been identified from unloading process, pressing process and winding process. In term of the WMDs risk level, REBA and RULA assessment tools have indicated high risk level to unloading and pressing process. Thus, this study had established the WMDs risk factor and risk level of core assembly production in an electronic components manufacturing company at Malaysia environment.

  10. Real-Time Observation of Exciton-Phonon Coupling Dynamics in Self-Assembled Hybrid Perovskite Quantum Wells.

    Science.gov (United States)

    Ni, Limeng; Huynh, Uyen; Cheminal, Alexandre; Thomas, Tudor H; Shivanna, Ravichandran; Hinrichsen, Ture F; Ahmad, Shahab; Sadhanala, Aditya; Rao, Akshay

    2017-11-28

    Self-assembled hybrid perovskite quantum wells have attracted attention due to their tunable emission properties, ease of fabrication, and device integration. However, the dynamics of excitons in these materials, especially how they couple to phonons, remains an open question. Here, we investigate two widely used materials, namely, butylammonium lead iodide (CH 3 (CH 2 ) 3 NH 3 ) 2 PbI 4 and hexylammonium lead iodide (CH 3 (CH 2 ) 5 NH 3 ) 2 PbI 4 , both of which exhibit broad photoluminescence tails at room temperature. We performed femtosecond vibrational spectroscopy to obtain a real-time picture of the exciton-phonon interaction and directly identified the vibrational modes that couple to excitons. We show that the choice of the organic cation controls which vibrational modes the exciton couples to. In butylammonium lead iodide, excitons dominantly couple to a 100 cm -1 phonon mode, whereas in hexylammonium lead iodide, excitons interact with phonons with frequencies of 88 and 137 cm -1 . Using the determined optical phonon energies, we analyzed photoluminescence broadening mechanisms. At low temperatures (photoluminescence line shape observed in hybrid perovskite quantum wells and provide insights into the mechanism of exciton-phonon coupling in these materials.

  11. Ellerman bombs observed with the new vacuum solar telescope and the atmospheric imaging assembly onboard the solar dynamics observatory

    Science.gov (United States)

    Chen, Yajie; Tian, Hui; Xu, Zhi; Xiang, Yongyuan; Fang, Yuliang; Yang, Zihao

    2017-12-01

    Ellerman bombs (EBs) are believed to be small-scale reconnection events occurring around the temperature minimum region in the solar atmosphere. They are often identified as significant enhancements in the extended Hα wings without obvious signatures in the Hα core. Here we explore the possibility of using the 1700 Å images taken by the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO) to study EBs. From the Hα wing images obtained with the New Vacuum Solar Telescope (NVST) on 2015 May 2, we have identified 145 EBs and 51% of them clearly correspond to the bright points (BPs) in the AIA 1700 Å images. If we resize the NVST images using a linear interpolation to make the pixel sizes of the AIA and NVST images the same, some previously identified EBs disappear and about 71% of the remaining EBs are associated with BPs. Meanwhile, 66% of the compact brightenings in the AIA 1700 Å images can be identified as EBs in the Hα wings. The intensity enhancements of the EBs in the Hα wing images reveal a linear correlation with those of the BPs in the AIA 1700 Å images. Our study suggests that a significant fraction of EBs can be observed with the AIA 1700 Å filter, which is promising for large-sample statistical study of EBs as the seeing-free and full-disk SDO/AIA data are routinely available.

  12. Dynamic assembly, localization and proteolysis of the Bacillus subtilis SMC complex

    Directory of Open Access Journals (Sweden)

    Rinn Cornelia

    2005-06-01

    Full Text Available Abstract Background SMC proteins are key components of several protein complexes that perform vital tasks in different chromosome dynamics. Bacterial SMC forms a complex with ScpA and ScpB that is essential for chromosome arrangement and segregation. The complex localizes to discrete centres on the nucleoids that during most of the time of the cell cycle localize in a bipolar manner. The complex binds to DNA and condenses DNA in an as yet unknown manner. Results We show that in vitro, ScpA and ScpB form different complexes with each other, among which the level of the putative 2 ScpA/4 ScpB complex showed a pronounced decrease in level upon addition of SMC protein. Different mutations of the ATPase-binding pocket of SMC reduced, but did not abolish interaction of mutant SMC with ScpA and ScpB. The loss of SMC ATPase activity led to a loss of function in vivo, and abolished proper localization of the SMC complex. The formation of bipolar SMC centres was also lost after repression of gyrase activity, and was abnormal during inhibition of replication, resulting in single central clusters. Resumption of replication quickly re-established bipolar SMC centres, showing that proper localization depends on ongoing replication. We also found that the SMC protein is subject to induced proteolysis, most strikingly as cells enter stationary phase, which is partly achieved by ClpX and LonA proteases. Atomic force microscopy revealed the existence of high order rosette-like SMC structures in vitro, which might explain the formation of the SMC centres in vivo. Conclusion Our data suggest that a ScpA/ScpB sub-complex is directly recruited into the SMC complex. This process does not require SMC ATPase activity, which, however, appears to facilitate loading of ScpA and ScpB. Thus, the activity of SMC could be regulated through binding and release of ScpA and ScpB, which has been shown to affect SMC ATPase activity. The proper bipolar localization of the SMC

  13. Network spandrels reflect ecological assembly.

    Science.gov (United States)

    Maynard, Daniel S; Serván, Carlos A; Allesina, Stefano

    2018-03-01

    Ecological networks that exhibit stable dynamics should theoretically persist longer than those that fluctuate wildly. Thus, network structures which are over-represented in natural systems are often hypothesised to be either a cause or consequence of ecological stability. Rarely considered, however, is that these network structures can also be by-products of the processes that determine how new species attempt to join the community. Using a simulation approach in tandem with key results from random matrix theory, we illustrate how historical assembly mechanisms alter the structure of ecological networks. We demonstrate that different community assembly scenarios can lead to the emergence of structures that are often interpreted as evidence of 'selection for stability'. However, by controlling for the underlying selection pressures, we show that these assembly artefacts-or spandrels-are completely unrelated to stability or selection, and are instead by-products of how new species are introduced into the system. We propose that these network-assembly spandrels are critically overlooked aspects of network theory and stability analysis, and we illustrate how a failure to adequately account for historical assembly can lead to incorrect inference about the causes and consequences of ecological stability. © 2018 John Wiley & Sons Ltd/CNRS.

  14. Fuel assembly

    International Nuclear Information System (INIS)

    Kawai, Mitsuo.

    1988-01-01

    Purpose: To reduce the corrosion rate and suppress the increase of radioactive corrosion products in reactor water of nuclear fuel assemblies for use in BWR type reactors having spacer springs made of nickel based deposition reinforced type alloys. Constitution: Spacer rings made of nickel based deposition reinforced type alloy are incorporated and used as fuel assemblies after applying treatment of dipping and maintaining at high temperature water followed by heating in steams. Since this can remove the nickel leaching into reactor water at the initial stage, Co-58 as the radioactive corrosion products in the reactor water can be reduced, and the operation at in-service inspection or repairement can be facilitated to improve the working efficiency of the nuclear power plant. The dipping time is desirably more than 10 hours and more desirably more than 30 hours. (Horiuchi, T. )

  15. 75 FR 14467 - In the Matter of: Certain Dynamic Random Access Memory Semiconductors and Products Containing...

    Science.gov (United States)

    2010-03-25

    ... Access Memory Semiconductors and Products Containing Same, Including Memory Modules; Notice of... semiconductors and products containing same, including memory modules, by reason of infringement of certain... importation of certain dynamic random access memory semiconductors or products containing the same, including...

  16. Yeast diversity and dynamics in the production processes of Norwegian dry-cured meat products.

    Science.gov (United States)

    Asefa, Dereje T; Møretrø, Trond; Gjerde, Ragnhild O; Langsrud, Solveig; Kure, Cathrine F; Sidhu, Maan S; Nesbakken, Truls; Skaar, Ida

    2009-07-31

    This study investigate the diversity and dynamics of yeasts in the production processes of one unsmoked and two smoked dry-cured meat products of a Norwegian dry-cured meat production facility. A longitudinal observational study was performed to collect 642 samples from the meat, production materials, room installations and indoor and outdoor air of the production facility. Nutrient rich agar media were used to isolate the yeasts. Morphologically different isolates were re-cultivated in their pure culture forms. Both classical and molecular methods were employed for species identification. Totally, 401 yeast isolates belonging to 10 species of the following six genera were identified: Debaryomyces, Candida, Rhodotorula, Rhodosporidium, Cryptococcus and Sporidiobolus. Debaryomyces hansenii and Candida zeylanoides were dominant and contributed by 63.0% and 26.4% respectively to the total isolates recovered from both smoked and unsmoked products. The yeast diversity was higher at the pre-salting production processes with C. zeylanoides being the dominant. Later at the post-salting stages, D. hansenii occurred frequently. Laboratory studies showed that D. hansenii was more tolerant to sodium chloride and nitrite than C. zeylanoides. Smoking seems to have a killing or a temporary growth inhibiting effect on yeasts that extend to the start of the drying process. Yeasts were isolated only from 31.1% of the environmental samples. They belonged to six different species of which five of them were isolated from the meat samples too. Debaryomyces hansenii and Rhodotorula glutinis were dominant with a 62.6% and 22.0% contribution respectively. As none of the air samples contained D. hansenii, the production materials and room installations used in the production processes were believed to be the sources of contamination. The dominance of D. hansenii late in the production process replacing C. zeylanoides should be considered as a positive change both for the quality and safety

  17. Reduced-order computational model in nonlinear structural dynamics for structures having numerous local elastic modes in the low-frequency range. Application to fuel assemblies

    International Nuclear Information System (INIS)

    Batou, A.; Soize, C.; Brie, N.

    2013-01-01

    Highlights: • A ROM of a nonlinear dynamical structure is built with a global displacements basis. • The reduced order model of fuel assemblies is accurate and of very small size. • The shocks between grids of a row of seven fuel assemblies are computed. -- Abstract: We are interested in the construction of a reduced-order computational model for nonlinear complex dynamical structures which are characterized by the presence of numerous local elastic modes in the low-frequency band. This high modal density makes the use of the classical modal analysis method not suitable. Therefore the reduced-order computational model is constructed using a basis of a space of global displacements, which is constructed a priori and which allows the nonlinear dynamical response of the structure observed on the stiff part to be predicted with a good accuracy. The methodology is applied to a complex industrial structure which is made up of a row of seven fuel assemblies with possibility of collisions between grids and which is submitted to a seismic loading

  18. Reduced-order computational model in nonlinear structural dynamics for structures having numerous local elastic modes in the low-frequency range. Application to fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Batou, A., E-mail: anas.batou@univ-paris-est.fr [Université Paris-Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 5 bd Descartes, 77454 Marne-la-Vallee (France); Soize, C., E-mail: christian.soize@univ-paris-est.fr [Université Paris-Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 5 bd Descartes, 77454 Marne-la-Vallee (France); Brie, N., E-mail: nicolas.brie@edf.fr [EDF R and D, Département AMA, 1 avenue du général De Gaulle, 92140 Clamart (France)

    2013-09-15

    Highlights: • A ROM of a nonlinear dynamical structure is built with a global displacements basis. • The reduced order model of fuel assemblies is accurate and of very small size. • The shocks between grids of a row of seven fuel assemblies are computed. -- Abstract: We are interested in the construction of a reduced-order computational model for nonlinear complex dynamical structures which are characterized by the presence of numerous local elastic modes in the low-frequency band. This high modal density makes the use of the classical modal analysis method not suitable. Therefore the reduced-order computational model is constructed using a basis of a space of global displacements, which is constructed a priori and which allows the nonlinear dynamical response of the structure observed on the stiff part to be predicted with a good accuracy. The methodology is applied to a complex industrial structure which is made up of a row of seven fuel assemblies with possibility of collisions between grids and which is submitted to a seismic loading.

  19. Endurance test for IR rig for RI production assembly (test procedure)

    International Nuclear Information System (INIS)

    Chung, Heung June; Ryu, Jeong Soo

    2000-08-01

    This test procedure details the test loop, test method, and test procedure for pressure drop, vibration and endurance test of IR Rig for RI production. From the pressure drop test, the hydraulic design requirements of the capsule are verified. HANARO limit condition is checked and the compatibility with HANARO core is verified. From flow induced vibration test vibration frequency and displacement are investigated. The wear of IR Rig is investigated through endurance test, and these data are used to evaluate the expected wear at maximum resident time of the IR Rig for RI production

  20. Terminating DNA Tile Assembly with Nanostructured Caps.

    Science.gov (United States)

    Agrawal, Deepak K; Jiang, Ruoyu; Reinhart, Seth; Mohammed, Abdul M; Jorgenson, Tyler D; Schulman, Rebecca

    2017-10-24

    Precise control over the nucleation, growth, and termination of self-assembly processes is a fundamental tool for controlling product yield and assembly dynamics. Mechanisms for altering these processes programmatically could allow the use of simple components to self-assemble complex final products or to design processes allowing for dynamic assembly or reconfiguration. Here we use DNA tile self-assembly to develop general design principles for building complexes that can bind to a growing biomolecular assembly and terminate its growth by systematically characterizing how different DNA origami nanostructures interact with the growing ends of DNA tile nanotubes. We find that nanostructures that present binding interfaces for all of the binding sites on a growing facet can bind selectively to growing ends and stop growth when these interfaces are presented on either a rigid or floppy scaffold. In contrast, nucleation of nanotubes requires the presentation of binding sites in an arrangement that matches the shape of the structure's facet. As a result, it is possible to build nanostructures that can terminate the growth of existing nanotubes but cannot nucleate a new structure. The resulting design principles for constructing structures that direct nucleation and termination of the growth of one-dimensional nanostructures can also serve as a starting point for programmatically directing two- and three-dimensional crystallization processes using nanostructure design.

  1. Matrix product algorithm for stochastic dynamics on networks applied to nonequilibrium Glauber dynamics

    Science.gov (United States)

    Barthel, Thomas; De Bacco, Caterina; Franz, Silvio

    2018-01-01

    We introduce and apply an efficient method for the precise simulation of stochastic dynamical processes on locally treelike graphs. Networks with cycles are treated in the framework of the cavity method. Such models correspond, for example, to spin-glass systems, Boolean networks, neural networks, or other technological, biological, and social networks. Building upon ideas from quantum many-body theory, our approach is based on a matrix product approximation of the so-called edge messages—conditional probabilities of vertex variable trajectories. Computation costs and accuracy can be tuned by controlling the matrix dimensions of the matrix product edge messages (MPEM) in truncations. In contrast to Monte Carlo simulations, the algorithm has a better error scaling and works for both single instances as well as the thermodynamic limit. We employ it to examine prototypical nonequilibrium Glauber dynamics in the kinetic Ising model. Because of the absence of cancellation effects, observables with small expectation values can be evaluated accurately, allowing for the study of decay processes and temporal correlations.

  2. Dynamical pion production via parametric resonance from disoriented chiral condensates

    Science.gov (United States)

    Hiro-Oka, Hideaki; Minakata, Hisakazu

    2000-04-01

    We discuss a dynamical mechanism of pion production from disoriented chiral condensates. It leads to an explosive production of pions via the parametric resonance mechanism, which is similar to the reheating mechanism in inflationary cosmology. Classically it is related with the instability in the solutions of the Mathieu equation and we explore the quantum aspects of the mechanism. We show that nonlinearities and back reactions can be ignorable for a sufficiently long time under the small amplitude approximations of background σ oscillations, which may be appropriate for the late stage of a nonequilibrium phase transition. It allows us to obtain an explicit quantum state of the produced pions and σ, the squeezed state of BCS type. Single particle distributions and two pion correlation functions are computed within these approximations. The results obtained illuminate the characteristic features of multipion states produced through the parametric amplification mechanism. In particular, two pion correlations of various charge combinations contain back-to-back correlations which cannot be masked by the identical particle interference effect. We suggest that the parametric resonance mechanism might be a cause of the long lasting amplification of low-momentum modes in linear sigma model simulations.

  3. Modular Nuclease-Responsive DNA Three-Way Junction-Based Dynamic Assembly of a DNA Device and Its Sensing Application.

    Science.gov (United States)

    Zhu, Jing; Wang, Lei; Xu, Xiaowen; Wei, Haiping; Jiang, Wei

    2016-04-05

    Here, we explored a modular strategy for rational design of nuclease-responsive three-way junctions (TWJs) and fabricated a dynamic DNA device in a "plug-and-play" fashion. First, inactivated TWJs were designed, which contained three functional domains: the inaccessible toehold and branch migration domains, the specific sites of nucleases, and the auxiliary complementary sequence. The actions of different nucleases on their specific sites in TWJs caused the close proximity of the same toehold and branch migration domains, resulting in the activation of the TWJs and the formation of a universal trigger for the subsequent dynamic assembly. Second, two hairpins (H1 and H2) were introduced, which could coexist in a metastable state, initially to act as the components for the dynamic assembly. Once the trigger initiated the opening of H1 via TWJs-driven strand displacement, the cascade hybridization of hairpins immediately switched on, resulting in the formation of the concatemers of H1/H2 complex appending numerous integrated G-quadruplexes, which were used to obtain label-free signal readout. The inherent modularity of this design allowed us to fabricate a flexible DNA dynamic device and detect multiple nucleases through altering the recognition pattern slightly. Taking uracil-DNA glycosylase and CpG methyltransferase M.SssI as models, we successfully realized the butt joint between the uracil-DNA glycosylase and M.SssI recognition events and the dynamic assembly process. Furthermore, we achieved ultrasensitive assay of nuclease activity and the inhibitor screening. The DNA device proposed here will offer an adaptive and flexible tool for clinical diagnosis and anticancer drug discovery.

  4. Economic consequences of QA and QC in fuel and fuel assembly production

    International Nuclear Information System (INIS)

    Strasser, A.A.

    1984-01-01

    The planning of quality control and quality assurance programs for fuel fabrication must balance the cost of the programs, their effectiveness, and the economic consequences of failure to meet the product specifications. The cost of fuel failures can be very high in comparison to the cost of quality control, and this provides considerable economic justification for increasing the level of quality control if its effectiveness in reducing failure potential can be demonstrated. Typical costs and examples are discussed. (orig.)

  5. Development of the control assembly pattern and dynamic analysis of the Generation IV large gas-cooled fast reactor (GFR)

    Energy Technology Data Exchange (ETDEWEB)

    Girardin, G.

    2009-07-15

    During the past ten years, different independent factors, such as the rapidly increasing worldwide demand in energy, societal concerns about greenhouse gas emissions, and the high and volatile prices for fossil fuels, have contributed to the renewed interest in nuclear technology. In this context, the Generation IV International Forum (GIF) launched the initiative to collaborate on the research and development efforts needed for the next generation of nuclear reactors. A particular goal set for Generation IV systems is closure of the nuclear fuel cycle; they are expected to offer a better utilization of natural resources, as also a minimization of long-lived radioactive wastes. Among the systems selected by the GIF, the Gas-cooled Fast Reactor (GFR) is a highly innovative system with advanced fuel geometry and materials. The principal aim of the present research is to develop and qualify the control assembly (CA) pattern and corresponding CA implementation scheme for the 2400 MWth reference GFR design. The work has been carried out in three successive phases: (1) validation of the neutronics tools, (2) the CA pattern development and related static analysis, and (3) dynamic core behaviour studies for hypothetical CA driven transients. The deterministic code system ERANOS and its associated nuclear data libraries for fast reactors were developed and validated for sodium-cooled reactors. In order to validate ERANOS for GFR applications, a systematic reanalysis of the GFR-relevant integral data generated at PSI during the GCFR-PROTEUS experimental program of the 1970’s was undertaken. The reference PROTEUS test lattice has been analyzed with ERANOS-2.0 and its associated, adjusted nuclear data library ERALIB1. Benchmark calculations were performed with the Monte Carlo code MCNPX, allowing one to both check the deterministic results and to analyze the sensitivity to different modern data libraries. For the main reaction rate ratios, the new analysis of the GCFR

  6. Development of the control assembly pattern and dynamic analysis of the Generation IV large gas-cooled fast reactor (GFR)

    International Nuclear Information System (INIS)

    Girardin, G.

    2009-07-01

    During the past ten years, different independent factors, such as the rapidly increasing worldwide demand in energy, societal concerns about greenhouse gas emissions, and the high and volatile prices for fossil fuels, have contributed to the renewed interest in nuclear technology. In this context, the Generation IV International Forum (GIF) launched the initiative to collaborate on the research and development efforts needed for the next generation of nuclear reactors. A particular goal set for Generation IV systems is closure of the nuclear fuel cycle; they are expected to offer a better utilization of natural resources, as also a minimization of long-lived radioactive wastes. Among the systems selected by the GIF, the Gas-cooled Fast Reactor (GFR) is a highly innovative system with advanced fuel geometry and materials. The principal aim of the present research is to develop and qualify the control assembly (CA) pattern and corresponding CA implementation scheme for the 2400 MWth reference GFR design. The work has been carried out in three successive phases: (1) validation of the neutronics tools, (2) the CA pattern development and related static analysis, and (3) dynamic core behaviour studies for hypothetical CA driven transients. The deterministic code system ERANOS and its associated nuclear data libraries for fast reactors were developed and validated for sodium-cooled reactors. In order to validate ERANOS for GFR applications, a systematic reanalysis of the GFR-relevant integral data generated at PSI during the GCFR-PROTEUS experimental program of the 1970’s was undertaken. The reference PROTEUS test lattice has been analyzed with ERANOS-2.0 and its associated, adjusted nuclear data library ERALIB1. Benchmark calculations were performed with the Monte Carlo code MCNPX, allowing one to both check the deterministic results and to analyze the sensitivity to different modern data libraries. For the main reaction rate ratios, the new analysis of the GCFR

  7. Development of the control assembly pattern and dynamic analysis of the generation IV large gas-cooled fast reactor (GFR)

    International Nuclear Information System (INIS)

    Girardin, G.

    2009-01-01

    Among the systems selected by the GIF, the Gas-cooled Fast Reactor (GFR) is a highly innovative system with advanced fuel geometry and materials. It is in the context of the large, 2400 MWth reference GFR design that the present doctoral research has been conducted, the principal aim having been to develop and qualify the control assembly (CA) pattern and corresponding CA implementation scheme for this system. The work has been carried out in three successive and complementary phases: (1) validation of the neutronics tools, (2) the CA pattern development and related static analysis, and (3) dynamic core behavior studies for hypothetical CA driven transients. During the first phase of the thesis, the reference PROTEUS test lattice from these experiments has been analyzed with ERANOS-2.0 and its associated, adjusted nuclear data library ERALIB1. Additionally, benchmark calculations were performed with the Monte Carlo code MCNPX, allowing one to both check the deterministic results and to analyze the sensitivity to different modern data libraries. It has been found that, for the main reaction rate ratios, the new analysis of the GCFR-PROTEUS reference lattice generally yields good agreement - within 1σ measurement uncertainty - with experimental values and with the Monte Carlo simulations. As shown by the analysis, the predictions were in somewhat better agreement in the case of the adjusted ERALIB1 library. The applicability of ERANOS-2.0/ERALIB1 as the reference neutronics tool for the GFR analysis could thus be demonstrated. Furthermore, neutronics aspects related to the novel features of the GFR, for which new experimental investigations are needed, were highlighted. In the second phase of the research, the CA pattern was developed for the GFR, based on iterative neutronics and thermal-hydraulics calculations, 2D and 3D neutronics models for the reactor core having first been set up using the reference ERANOS-2.0/ERALIB1 computational scheme. For the thermal

  8. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

    Science.gov (United States)

    Huang, William Y C; Yan, Qingrong; Lin, Wan-Chen; Chung, Jean K; Hansen, Scott D; Christensen, Sune M; Tu, Hsiung-Lin; Kuriyan, John; Groves, Jay T

    2016-07-19

    The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the LAT assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the LAT assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. The generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes.

  9. Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase.

    Science.gov (United States)

    Moss, David K; Wilde, Andrew; Lane, Jon D

    2009-03-01

    During apoptosis, the interphase microtubule network is dismantled then later replaced by a novel, non-centrosomal microtubule array. These microtubules assist in the peripheral redistribution of nuclear fragments in the apoptotic cell; however, the regulation of apoptotic microtubule assembly is not understood. Here, we demonstrate that microtubule assembly depends upon the release of nuclear RanGTP into the apoptotic cytoplasm because this process is blocked in apoptotic cells overexpressing dominant-negative GDP-locked Ran (T24N). Actin-myosin-II contractility provides the impetus for Ran release and, consequently, microtubule assembly is blocked in blebbistatin- and Y27632-treated apoptotic cells. Importantly, the spindle-assembly factor TPX2 (targeting protein for Xklp2), colocalises with apoptotic microtubules, and siRNA silencing of TPX2, but not of the microtubule motors Mklp1 and Kid, abrogates apoptotic microtubule assembly. These data provide a molecular explanation for the assembly of the apoptotic microtubule network, and suggest important similarities with the process of RanGTP- and TPX2-mediated mitotic spindle formation.

  10. Self-assembled supramolecular system PDINH on TiO2 surface enhances hydrogen production.

    Science.gov (United States)

    Li, Xin; Lv, Xingshuai; Zhang, Qianqian; Huang, Baibiao; Wang, Peng; Qin, Xiaoyan; Zhang, Xiaoyang; Dai, Ying

    2018-09-01

    Constructing organic-inorganic hybrids is one of the hopeful strategies to improve photocatalyst performance. In this study, perylene-3,4,9,10-tetracarboxylic diimide (PDINH) and commercial TiO 2 P25 are chosen as raw materials to construct a PDINH/TiO 2 organic-inorganic hybrid, which has higher photocatalytic H 2 production activity and photocurrent intensity than pure PDINH and TiO 2 , respectively. The apparent quantum efficiency for H 2 production over 0.5%PDINH/TiO 2 reaches as high as 70.69% using irradiation at 365 nm. Moreover, XRD, DRS, HRTEM, FT-IR, and XPS are used to characterize the crystal structure, optical absorption, morphology, molecular structure, and chemical bonds, as well as the elemental and chemical states of PDINH/TiO 2 organic-inorganic hybrid. The interfaces between PDINH and TiO 2 , which largely determine photocatalytic performance, is also analyzed systematically. Furthermore, charge density difference (Δρ) is used to analyze the electron-ion interactions of PDINH and TiO 2 , and reveals that substantial charge transfer occurs from PDINH to TiO 2 . Copyright © 2018. Published by Elsevier Inc.

  11. Static and dynamic investigations of poly(aspartic acid) and Pluronic F127 complex prepared by self-assembling in aqueous solution

    Science.gov (United States)

    Nita, Loredana E.; Chiriac, Aurica P.; Bercea, Maria; Nistor, Manuela T.

    2015-12-01

    The present investigation is focused on evaluation of self-assembling ability in aqueous solutions of two water soluble polymers: poly(aspartic acid) (PAS) and Pluronic F127 (PL). The intermolecular complexes, realized between polyacid and neutral copolymer surfactant in different ratios, have been studied by combining various characterization techniques as rheology, DLS, spectroscopy, microscopy, chemical imaging, and zeta potential determination, measurements performed in static and/or dynamic conditions. In static conditions, when the equilibrium state between PAS/PL polymeric pair was reached, and depending on the polymers mixture composition, and of experimental rheological conditions, positive or negative deviations from the additive rule are registered. Conformational changes of the macromolecular chains and correspondingly physical interactions are generated between PL and PAS for self-assembly and the formation of interpolymer complex as suprastructure with micellar configuration. The phenomenon was better evidenced in case of 1/1 wt ratio between the two polymers. In dynamic conditions of determination, during ;in situ; evaluation of the hydrodynamic diameter, zeta potential and conductivity, when the equilibrium state is not reached and as result either the intermolecular bonds are not achieved, the self-assembling process is not so obvious evidenced.

  12. Assembly and calibration of a new experimental apparatus for production and utilization of capture gamma rays

    International Nuclear Information System (INIS)

    Semmler, R.

    1993-01-01

    A new experimental apparatus has been mounted at the tangential beam tube B H 4/12 of the IPEN IEA-R1 (2 MW) reactor, for production and utilization of capture gamma rays. In this type of experiment, monochromatic gamma radiation, with energy resolution of about 10 eV, is produced by thermal neutron capture in several materials placed near the reactor core. By changing the target material it was possible to obtain up to 30 gamma lines in the 5 to 11 MeV energy range and so, the present experimental arrangement may be considered as an excellent gamma ray source for photonuclear reactions studies in low excitation energies. (author)

  13. Nuclear performance of target-blanket assemblies for electronuclear fuel production

    International Nuclear Information System (INIS)

    Alsmiller, R.G. Jr.; Gabriel, T.A.; Barish, J.

    1978-01-01

    The results of calculations of high energy transport carried out to evaluate the nuclear performance of several of the designs that have been proposed for electronuclear fuel production are presented. Topics covered include: results for 1-GeV protons and 1-GeV deuterons incident on a lithium target surrounded by a 238 U blanket; results for 1 GeV protons and 1-GeV deuterons incident on a thorium salt; results for 1-GeV protons, incident on a gas-cooled system fueled by either 238 UO 2 or 232 ThO 2 ; and results for protons in the energy range 0.5 to 10 GeV incident on a very large natural uranium target

  14. Study and survey of assembling parameters to a radioactive source production laboratory used to verify equipment

    International Nuclear Information System (INIS)

    Gauglitz, Erica

    2010-01-01

    This paper presents a survey of parameters for the proper and safe flooring, doors, windows, fume hoods and others, in a radiochemical laboratory. The layout of each item follows guidelines and national standards of the National Commission of Nuclear Energy (CNEN) and the International Atomic Energy Agency (IAEA), aiming to ensure the radiological protection of workers and environment. The adequate items arrangement in the radiochemical laboratory ensures quality and safety in the production of 57 Co 137 Cs and 133 Ba radioactive sealed sources, with activities 185, 9.3 and 5.4 MBq, respectively. These sources are used to verify meter activity equipment and should be available throughout the Nuclear Medicine Center, following the recommendations of CNEN-NN-3.05 standard R equirements for Radiation Protection and Safety Services for Nuclear Medicine , to verify the activity of radiopharmaceuticals that are administered in patients, for diagnosis and therapy. Verification of measuring activity equipment will be used to perform accuracy, reproducibility and linearity tests, which should show results within the limits specified in the standard CNEN-NN-3.05. (author)

  15. Neutron production with a pyroelectric double-crystal assembly without nano-tip

    International Nuclear Information System (INIS)

    Tornow, W.; Corse, W.; Crimi, S.; Fox, J.

    2010-01-01

    Two cylindrical LiTaO 3 crystals facing each other's deuterated circular face were exposed to deuterium gas at an ambient pressure of a few mTorr. With a distance of about 4 cm between the z + and z - cut crystal faces, neutrons were produced via the 2 H(d,n) 3 He fusion reaction upon the heating and cooling of the crystals. The 2.5 MeV neutrons were detected with organic liquid scintillation detectors equipped with neutron-gamma pulse-shape discrimination electronics to reject pulses generated by the intense X-ray flux. During the cooling phase of naked crystals, deuterium ion-beam (D 2 + ) energies of up to 400 keV were obtained as deduced from the associated electron bremsstrahlung end-point energy. The highest electron-beam energy observed during the heating phase was 360 keV. With a layer of deuterated polyethylene evaporated on the front face of the crystals, the maximal energies were about 10% lower. In contrast to earlier studies, an electric-field enhancing nano-tip was not employed. Neutron yields up to 500 per thermal cycle were observed, resulting in a total neutron production yield of about 1.6x10 4 neutrons per thermal cycle. Our approach has the potential of being substantially improved by reducing the frequency of the discharges we are currently experiencing with our geometry, which was not designed for the unprecedented high potentials produced in the presentwork.

  16. CANDELS : THE COSMIC ASSEMBLY NEAR-INFRARED DEEP EXTRAGALACTIC LEGACY SURVEY-THE HUBBLE SPACE TELESCOPE OBSERVATIONS, IMAGING DATA PRODUCTS, AND MOSAICS

    NARCIS (Netherlands)

    Koekemoer, Anton M.; Faber, S. M.; Ferguson, Henry C.; Grogin, Norman A.; Kocevski, Dale D.; Koo, David C.; Lai, Kamson; Lotz, Jennifer M.; Lucas, Ray A.; McGrath, Elizabeth J.; Ogaz, Sara; Rajan, Abhijith; Riess, Adam G.; Rodney, Steve A.; Strolger, Louis; Casertano, Stefano; Castellano, Marco; Dahlen, Tomas; Dickinson, Mark; Dolch, Timothy; Fontana, Adriano; Giavalisco, Mauro; Grazian, Andrea; Guo, Yicheng; Hathi, Nimish P.; Huang, Kuang-Han; van der Wel, Arjen; Yan, Hao-Jing; Acquaviva, Viviana; Alexander, David M.; Almaini, Omar; Ashby, Matthew L. N.; Barden, Marco; Bell, Eric F.; Bournaud, Frederic; Brown, Thomas M.; Caputi, Karina I.; Cassata, Paolo; Challis, Peter J.; Chary, Ranga-Ram; Cheung, Edmond; Cirasuolo, Michele; Conselice, Christopher J.; Cooray, Asantha Roshan; Croton, Darren J.; Daddi, Emanuele; Dave, Romeel; de Mello, Duilia F.; de Ravel, Loic; Dekel, Avishai; Donley, Jennifer L.; Dunlop, James S.; Dutton, Aaron A.; Elbaz, David; Fazio, Giovanni G.; Filippenko, Alexei V.; Finkelstein, Steven L.; Frazer, Chris; Gardner, Jonathan P.; Garnavich, Peter M.; Gawiser, Eric; Gruetzbauch, Ruth; Hartley, Will G.; Haeussler, Boris; Herrington, Jessica; Hopkins, Philip F.; Huang, Jia-Sheng; Jha, Saurabh W.; Johnson, Andrew; Kartaltepe, Jeyhan S.; Khostovan, Ali A.; Kirshner, Robert P.; Lani, Caterina; Lee, Kyoung-Soo; Li, Weidong; Madau, Piero; McCarthy, Patrick J.; McIntosh, Daniel H.; McLure, Ross J.; McPartland, Conor; Mobasher, Bahram; Moreira, Heidi; Mortlock, Alice; Moustakas, Leonidas A.; Mozena, Mark; Nandra, Kirpal; Newman, Jeffrey A.; Nielsen, Jennifer L.; Niemi, Sami; Noeske, Kai G.; Papovich, Casey J.; Pentericci, Laura; Pope, Alexandra; Primack, Joel R.; Ravindranath, Swara; Reddy, Naveen A.; Renzini, Alvio; Rix, Hans-Walter; Robaina, Aday R.; Rosario, David J.; Rosati, Piero; Salimbeni, Sara; Scarlata, Claudia; Siana, Brian; Simard, Luc; Smidt, Joseph; Snyder, Diana; Somerville, Rachel S.; Spinrad, Hyron; Straughn, Amber N.; Telford, Olivia; Teplitz, Harry I.; Trump, Jonathan R.; Vargas, Carlos; Villforth, Carolin; Wagner, Cory R.; Wandro, Pat; Wechsler, Risa H.; Weiner, Benjamin J.; Wiklind, Tommy; Wild, Vivienne; Wilson, Grant; Wuyts, Stijn; Yun, Min S.

    2011-01-01

    This paper describes the Hubble Space Telescope imaging data products and data reduction procedures for the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). This survey is designed to document the evolution of galaxies and black holes at z approximate to 1.5-8, and to study

  17. Photocatalytic H 2 production from water splitting under visible light irradiation using Eosin Y-sensitized mesoporous-assembled Pt/TiO 2 nanocrystal photocatalyst

    Science.gov (United States)

    Sreethawong, Thammanoon; Junbua, Chompoonuch; Chavadej, Sumaeth

    Sensitized photocatalytic production of hydrogen from water splitting is investigated under visible light irradiation over mesoporous-assembled titanium dioxide (TiO 2) nanocrystal photocatalysts, without and with Pt loading. The photocatalysts are synthesized by a sol-gel process with the aid of a structure-directing surfactant and are characterized by N 2 adsorption-desorption analysis, X-ray diffraction, UV-vis spectroscopy, scanning electron microscopy, transmission electron microscopy and energy-dispersive X-ray analysis. The dependence of hydrogen production on the type of TiO 2 photocatalyst (synthesized mesoporous-assembled and commercial non-mesoporous-assembled TiO 2 without and with Pt loading), the calcination temperature of the synthesized photocatalyst, the sensitizer (Eosin Y) concentration, the electron donor (diethanolamine) concentration, the photocatalyst dosage and the initial solution pH is systematically studied. The results show that in the presence of the Eosin Y sensitizer, the Pt-loaded mesoporous-assembled TiO 2 synthesized by a single-step sol-gel process and calcined at 500 °C exhibits the highest photocatalytic activity for hydrogen production from a 30 vol.% diethanolamine aqueous solution with dissolved 2 mM Eosin Y. Moreover, the optimum photocatalyst dosage and initial solution pH for the maximum photocatalytic activity for hydrogen production are 3.33 g dm -3 and 11.5, respectively.

  18. Neutron production with a pyroelectric double-crystal assembly without nano-tip

    Energy Technology Data Exchange (ETDEWEB)

    Tornow, W., E-mail: tornow@tunl.duke.ed [Department of Physics, Duke University and Triangle Universities Nuclear Laboratory, Durham, NC 27708-0308 (United States); Corse, W. [Department of Physics, Duke University and Triangle Universities Nuclear Laboratory, Durham, NC 27708-0308 (United States); Crimi, S. [Harriet L. Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458 (United States); Fox, J. [Department of Physics, Duke University and Triangle Universities Nuclear Laboratory, Durham, NC 27708-0308 (United States)

    2010-12-21

    Two cylindrical LiTaO{sub 3} crystals facing each other's deuterated circular face were exposed to deuterium gas at an ambient pressure of a few mTorr. With a distance of about 4 cm between the z{sup +} and z{sup -} cut crystal faces, neutrons were produced via the {sup 2}H(d,n){sup 3}He fusion reaction upon the heating and cooling of the crystals. The 2.5 MeV neutrons were detected with organic liquid scintillation detectors equipped with neutron-gamma pulse-shape discrimination electronics to reject pulses generated by the intense X-ray flux. During the cooling phase of naked crystals, deuterium ion-beam (D{sub 2}{sup +}) energies of up to 400 keV were obtained as deduced from the associated electron bremsstrahlung end-point energy. The highest electron-beam energy observed during the heating phase was 360 keV. With a layer of deuterated polyethylene evaporated on the front face of the crystals, the maximal energies were about 10% lower. In contrast to earlier studies, an electric-field enhancing nano-tip was not employed. Neutron yields up to 500 per thermal cycle were observed, resulting in a total neutron production yield of about 1.6x10{sup 4} neutrons per thermal cycle. Our approach has the potential of being substantially improved by reducing the frequency of the discharges we are currently experiencing with our geometry, which was not designed for the unprecedented high potentials produced in the presentwork.

  19. Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components

    Science.gov (United States)

    Gerling, Thomas; Wagenbauer, Klaus F.; Neuner, Andrea M.; Dietz, Hendrik

    2015-03-01

    We demonstrate that discrete three-dimensional (3D) DNA components can specifically self-assemble in solution on the basis of shape-complementarity and without base pairing. Using this principle, we produced homo- and heteromultimeric objects, including micrometer-scale one- and two-stranded filaments and lattices, as well as reconfigurable devices, including an actuator, a switchable gear, an unfoldable nanobook, and a nanorobot. These multidomain assemblies were stabilized via short-ranged nucleobase stacking bonds that compete against electrostatic repulsion between the components’ interfaces. Using imaging by electron microscopy, ensemble and single-molecule fluorescence resonance energy transfer spectroscopy, and electrophoretic mobility analysis, we show that the balance between attractive and repulsive interactions, and thus the conformation of the assemblies, may be finely controlled by global parameters such as cation concentration or temperature and by an allosteric mechanism based on strand-displacement reactions.

  20. Bcs1p can rescue a large and productive cytochrome bc(1) complex assembly intermediate in the inner membrane of yeast mitochondria.

    Science.gov (United States)

    Conte, Laura; Trumpower, Bernard L; Zara, Vincenzo

    2011-01-01

    The yeast cytochrome bc(1) complex, a component of the mitochondrial respiratory chain, is composed of ten distinct protein subunits. In the assembly of the bc(1) complex, some ancillary proteins, such as the chaperone Bcs1p, are actively involved. The deletion of the nuclear gene encoding this chaperone caused the arrest of the bc(1) assembly and the formation of a functionally inactive bc(1) core structure of about 500-kDa. This immature bc(1) core structure could represent, on the one hand, a true assembly intermediate or, on the other hand, a degradation product and/or an incorrect product of assembly. The experiments here reported show that the gradual expression of Bcs1p in the yeast strain lacking this protein was progressively able to rescue the bc(1) core structure leading to the formation of the functional homodimeric bc(1) complex. Following Bcs1p expression, the mature bc(1) complex was also progressively converted into two supercomplexes with the cytochrome c oxidase complex. The capability of restoring the bc(1) complex and the supercomplexes was also possessed by the mutated yeast R81C Bcsp1. Notably, in the human ortholog BCS1L, the corresponding point mutation (R45C) was instead the cause of a severe bc(1) complex deficiency. Differently from the yeast R81C Bcs1p, two other mutated Bcs1p's (K192P and F401I) were unable to recover the bc(1) core structure in yeast. This study identifies for the first time a productive assembly intermediate of the yeast bc(1) complex and gives new insights into the molecular mechanisms involved in the last steps of bc(1) assembly. Copyright © 2010 Elsevier B.V. All rights reserved.

  1. Development of process route for production of tubing for various core sub-assemblies and heat exchangers for 500 MWe Indian PFBR

    International Nuclear Information System (INIS)

    Lakshminarayana, B.; Phani Babu, C.; Dubey, A.K.; Surender, A.; Deshpande, K.V.K.; Maity, P.K.

    2009-01-01

    India's three stage Nuclear Power Program has entered its second stage on commercial scale with the commencement of construction of 500 MWe Prototype Fast Breeder Reactor (PFBR) at Kalpakkam. Nuclear Fuel Complex (NFC), Hyderabad is playing a crucial role in the manufacture of all the critical sub-assemblies and control elements for this reactor. The challenging task of process development and production of the various critical tubing for these sub assemblies for PFBR has been taken up by Stainless Steel Tubes Plant (SSTP), NFC with indigenous development of the equipment and technology

  2. The role of quorum sensing signalling in EPS production and the assembly of a sludge community into aerobic granules.

    Science.gov (United States)

    Tan, Chuan Hao; Koh, Kai Shyang; Xie, Chao; Tay, Martin; Zhou, Yan; Williams, Rohan; Ng, Wun Jern; Rice, Scott A; Kjelleberg, Staffan

    2014-06-01

    Quorum sensing (QS) signalling has been extensively studied in single species populations. However, the ecological role of QS in complex, multi-species communities, particularly in the context of community assembly, has neither been experimentally explored nor theoretically addressed. Here, we performed a long-term bioreactor ecology study to address the links between QS, organization and composition of complex microbial communities. The conversion of floccular biomass to highly structured granules was found to be non-random, but strongly and positively correlated with N-acyl-homoserine-lactone (AHL)-mediated QS. Specific AHLs were elevated up to 100-fold and were strongly associated with the initiation of granulation. Similarly, the levels of particular AHLs decreased markedly during the granular disintegration phase. Metadata analysis indicated that granulation was accompanied by changes in extracellular polymeric substance (EPS) production and AHL add-back studies also resulted in increased EPS synthesis. In contrast to the commonly reported nanomolar to micromolar signal concentrations in pure culture laboratory systems, QS signalling in the granulation ecosystem occurred at picomolar to nanomolar concentrations of AHLs. Given that low concentrations of AHLs quantified in this study were sufficient to activate AHL bioreporters in situ in complex granular communities, AHL mediated QS may be a common feature in many natural and engineered ecosystems, where it coordinates community behaviour.

  3. In situ WetSTEM observation of gold nanorod self-assembly dynamics in a drying colloidal droplet

    Czech Academy of Sciences Publication Activity Database

    Novotný, F.; Wandrol, P.; Proška, J.; Šlouf, Miroslav

    2014-01-01

    Roč. 20, č. 2 (2014), s. 385-393 ISSN 1431-9276 R&D Projects: GA TA ČR TE01020118; GA ČR GAP205/10/0348 Institutional support: RVO:61389013 Keywords : gold nanorods * self-assembly * in situ Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.877, year: 2014

  4. Development of a membrane electrode assembly production process for proton exchange membrane fuel cell (PEMFC) by sieve printing

    International Nuclear Information System (INIS)

    Bonifacio, Rafael Nogueira

    2010-01-01

    Energy is a resource that presents historical trend of growth in demand. Projections indicate that future energy needs will require a massive use of hydrogen as fuel. The use of systems based on the use of proton exchange membrane fuel cell (PEMFC) has features that allow its application for stationary applications, automotive and portable power generation. The use of hydrogen as fuel for PEMFC has the advantage low pollutants' emission, when compared to fossil fuels. For the reactions in a PEMFC is necessary to build membrane electrode assembly (MEA). And the production of MEAs and its materials are relevant to the final cost of kW of power generated by systems of fuel cell. This represent currently a technological and financial barriers to large-scale application of this technology. In this work a process of MEAs fabrication were developed that showed high reproducibility, rapidity and low cost by sieve printing. The process of sieve printing and the ink composition as a precursor to the catalyst layer were developed, which allow the preparation of electrodes for MEAs fabrication with the implementation of the exact catalyst loading, 0.6 milligrams of platinum per square centimeters (mgPt.cm -2 ) suitable for cathodes and 0.4 mgPt.cm -2 for anode in only one application step per electrode. The ink was developed, produced, characterized and used with similar characteristics to ink of sieve printing build for other applications. The MEAs produced had a performance of up to 712 mA.cm -2 by 600 mV to 25 cm 2 MEA area. The MEA cost production for MEAs of 247.86 cm 2 , that can generate 1 kilowatt of energy was estimated to US$ 7,744.14 including cost of equipment, materials and labor. (author)

  5. Fuel assembly

    International Nuclear Information System (INIS)

    Wataumi, Kazutoshi; Tajiri, Hiroshi.

    1992-01-01

    In a fuel assembly of a BWR type reactor, a pellet to be loaded comprises an external layer of fissile materials containing burnable poisons and an internal layer of fissile materials not containing burnable poison. For example, there is provided a dual type pellet comprising an external layer made of UO 2 incorporated with Gd 2 O 3 at a predetermined concentration as the burnable poisons and an internal layer made of UO 2 not containing Gd 2 O 3 . The amount of the burnable poisons required for predetermined places is controlled by the thickness of the ring of the external layer. This can dissipate an unnecessary poisoning effect at the final stage of the combustion cycle. Further, since only one or a few kinds of powder mixture of the burnable poisons and the fissile materials is necessary, production and product control can be facilitated. (I.N.)

  6. Productivity and Regional Employment in Spain: A Dynamic Approach

    Directory of Open Access Journals (Sweden)

    F. Javier Escribá Pérez

    2013-01-01

    Full Text Available This paper analyses the impact of sectorial and territorial factors on the dynamics of employment in regional industries in Spain over the period 1980-2006. A dynamic panel data model is estimated using panel data techniques (System-GMM, which provide an alternative methodology for addressing the problem of variable endogeneity. The results confirm the robustness of the contemporary effects: diversification, market size and dynamics in the sector affect employment in the short term. However, effects in the long term are more uncertain.

  7. Components production and assemble of the irradiation capsule of the Surveillance Program of Materials of the nuclear power plant of Laguna Verde

    International Nuclear Information System (INIS)

    Medrano, A.

    2009-01-01

    To predict the effects of the neutrons radiation and the thermal environment about the mechanical properties of the reactor vessel materials of the nuclear power plant of Laguna Verde, a surveillance program is implemented according to the outlines settled by Astm E185-02 -Standard practice for design of surveillance programs for light-water moderated nuclear power reactor vessels-. This program includes the installation of three irradiation capsules of similar materials to those of the reactor vessels, these samples are test tubes for mechanical practices of impact and tension. In the National Institute of Nuclear Research and due to the infrastructure as well as of the actual human resources of the Pilot Plant of Nuclear Fuel Assembles Production it was possible to realize the materials rebuilding extracted in 2005 of Unit 2 of nuclear power plant of Laguna Verde as well as the production, assemble and reassignment of the irradiation capsule made in 2006. At the present time the surveillance materials extracted in 2008 of Unit 1 of the nuclear power plant of Laguna Verde are reconstituting and the components are manufactured for the assembles of the irradiation capsule that will be reinstalled in the reactor vessel in 2010. The purpose of the present work is to describe the necessary components as well as its disposition during the assembles of the irradiation capsule for the surveillance program of the reactors vessel of the nuclear power plant of Laguna Verde. (Author)

  8. Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE

    OpenAIRE

    Suefuji, Kyoko; Valluzzi, Regina; RayChaudhuri, Debabrata

    2002-01-01

    Accurate positioning of the division septum at the equator of Escherichia coli cells requires a rapid oscillation of MinD ATPase between the polar halves of the cell membrane, together with the division inhibitor MinC, under MinE control. The mechanism underlying MinD oscillation remains poorly understood. Here, we demonstrate that purified MinD assembles into protein filaments in the presence of ATP. Incubation with phospholipid vesicles further stimulates MinD polymerization. Addition of pu...

  9. Systems and methods for creation of conducting networks of magnetic particles through dynamic self-assembly process

    Science.gov (United States)

    Snezhko, Oleksiy [Woodridge, IL; Aronson, Igor [Darien, IL; Kwok, Wai-Kwong [Downers Grove, IL

    2011-01-25

    Self-assembly of magnetic microparticles in AC magnetic fields. Excitation of the system by an AC magnetic field provides a variety of patterns that can be controlled by adjusting the frequency and the amplitude of the field. At low particle densities the low-frequency magnetic excitation favors cluster phase formation, while high frequency excitation favors chains and netlike structures. For denser configurations, an abrupt transition to the network phase was obtained.

  10. Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET

    Science.gov (United States)

    Hardin, John W.; Warnasooriya, Chandani; Kondo, Yasushi; Nagai, Kiyoshi; Rueda, David

    2015-01-01

    In large ribonucleoprotein machines, such as ribosomes and spliceosomes, RNA functions as an assembly scaffold as well as a critical catalytic component. Protein binding to the RNA scaffold can induce structural changes, which in turn modulate subsequent binding of other components. The spliceosomal U4/U6 di-snRNP contains extensively base paired U4 and U6 snRNAs, Snu13, Prp31, Prp3 and Prp4, seven Sm and seven LSm proteins. We have studied successive binding of all protein components to the snRNA duplex during di-snRNP assembly by electrophoretic mobility shift assay and accompanying conformational changes in the U4/U6 RNA 3-way junction by single-molecule FRET. Stems I and II of the duplex were found to co-axially stack in free RNA and function as a rigid scaffold during the entire assembly, but the U4 snRNA 5′ stem-loop adopts alternative orientations each stabilized by Prp31 and Prp3/4 binding accounting for altered Prp3/4 binding affinities in presence of Prp31. PMID:26503251

  11. Consequences of Molecular-Scale Non-Equilibrium Activity on the Dynamics and Mechanics of Self-Assembled Actin-Based Structures and Materials

    Science.gov (United States)

    Marshall Mccall, Patrick

    Living cells are hierarchically self-organized forms of active soft matter: molecules on the nanometer scale form functional structures and organelles on the micron scale, which then compose cells on the scale of 10s of microns. While the biological functions of intracellular organelles are defined by the composition and properties of the structures themselves, how those bulk properties emerge from the properties and interactions of individual molecules remains poorly understood. Actin, a globular protein which self-assembles into dynamic semi-flexible polymers, is the basic structural material of cells and the major component of many functional organelles. In this thesis, I have used purified actin as a model system to explore the interplay between molecular-scale dynamics and organelle-scale functionality, with particular focus on the role of molecular-scale non-equilibrium activity. One of the most canonical forms of molecular-scale non-equilibrium activity is that of mechanoenzymes, also called motor proteins. These proteins utilized the free energy liberated by hydrolysis of ATP to perform mechanical work, thereby introducing non-equilibrium "active" stresses on the molecular scale. Combining experiments with mathematical modeling, we demonstrate in this thesis that non-equilibrium motor activity is sufficient to drive self-organization and pattern formation of the multimeric actin-binding motor protein Myosin II on 1D reconstituted actomyosin bundles. Like myosin, actin is itself an ATPase. However, nono-equilibrium ATP hydrolysis on actin is known to regulate the stability and assembly kinetics of actin filaments rather than generate active stresses per se. At the level of single actin filaments, the inhomogeneous nucleotide composition generated along the filament length by hydrolysis directs binding of regulatory proteins like cofilin, which mediate filament disassembly and thereby accelerate actin filament turnover. The concequences of this non

  12. De novo assembly, gene annotation, and marker discovery in stored-product pest Liposcelis entomophila (Enderlein using transcriptome sequences.

    Directory of Open Access Journals (Sweden)

    Dan-Dan Wei

    Full Text Available BACKGROUND: As a major stored-product pest insect, Liposcelis entomophila has developed high levels of resistance to various insecticides in grain storage systems. However, the molecular mechanisms underlying resistance and environmental stress have not been characterized. To date, there is a lack of genomic information for this species. Therefore, studies aimed at profiling the L. entomophila transcriptome would provide a better understanding of the biological functions at the molecular levels. METHODOLOGY/PRINCIPAL FINDINGS: We applied Illumina sequencing technology to sequence the transcriptome of L. entomophila. A total of 54,406,328 clean reads were obtained and that de novo assembled into 54,220 unigenes, with an average length of 571 bp. Through a similarity search, 33,404 (61.61% unigenes were matched to known proteins in the NCBI non-redundant (Nr protein database. These unigenes were further functionally annotated with gene ontology (GO, cluster of orthologous groups of proteins (COG, and Kyoto Encyclopedia of Genes and Genomes (KEGG databases. A large number of genes potentially involved in insecticide resistance were manually curated, including 68 putative cytochrome P450 genes, 37 putative glutathione S-transferase (GST genes, 19 putative carboxyl/cholinesterase (CCE genes, and other 126 transcripts to contain target site sequences or encoding detoxification genes representing eight types of resistance enzymes. Furthermore, to gain insight into the molecular basis of the L. entomophila toward thermal stresses, 25 heat shock protein (Hsp genes were identified. In addition, 1,100 SSRs and 57,757 SNPs were detected and 231 pairs of SSR primes were designed for investigating the genetic diversity in future. CONCLUSIONS/SIGNIFICANCE: We developed a comprehensive transcriptomic database for L. entomophila. These sequences and putative molecular markers would further promote our understanding of the molecular mechanisms underlying

  13. Fuel Assembly Damping Summary

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kanghee; Kang, Heungseok; Oh, Dongseok; Yoon, Kyungho; Kim, Hyungkyu; Kim, Jaeyong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    This paper summary the fuel assembly damping data in air/in still water/under flow, released from foreign fuel vendors, compared our data with the published data. Some technical issues in fuel assembly damping measurement testing are also briefly discussed. Understanding of each fuel assembly damping mechanisms according to the surrounding medium and flow velocity can support the fuel design improvement in fuel assembly dynamics and structural integrity aspect. Because the upgraded requirements of the newly-developed advanced reactor system will demands to minimize fuel design margin in integrity evaluation, reduction in conservatism of fuel assembly damping can contribute to alleviate the fuel design margin for sure. Damping is an energy dissipation mechanism in a vibrating mechanical structure and prevents a resonant structure from having infinite vibration amplitudes. The sources of fuel assembly damping are various from support friction to flow contribution, and it can be increased by the viscosity or drag of surrounding fluid medium or the average velocity of water flowing. Fuel licensing requires fuel design evaluation in transient or accidental condition. Dynamic response analysis of fuel assembly is to show fuel integrity and requires information on assembly-wise damping in dry condition and under wet or water flowing condition. However, damping measurement test for the full-scale fuel assembly prototype is not easy to carry out because of the scale (fuel prototype, test facility), unsteadiness of test data (scattering, random sampling and processing), instrumentation under water flowing (water-proof response measurement), and noise. LWR fuel technology division in KAERI is preparing the infra structure for damping measurement test of full-scale fuel assembly, to support fuel industries and related research activities. Here is a preliminary summary of fuel assembly damping, published in the literature. Some technical issues in fuel assembly damping

  14. Hydrogen production over Au-loaded mesoporous-assembled SrTiO3 nanocrystal photocatalyst: Effects of molecular structure and chemical properties of hole scavengers

    International Nuclear Information System (INIS)

    Puangpetch, Tarawipa; Chavadej, Sumaeth; Sreethawong, Thammanoon

    2011-01-01

    Graphical abstract: Formic acid, which is the smallest and completely-dissociated water-soluble carboxylic acid, exhibited the highest hydrogen production enhancement ability over the 1 wt.% Au-loaded mesoporous-assembled SrTiO 3 nanocrystal photocatalyst. Display Omitted Research highlights: → The 1 wt.% Au-loaded mesoporous-assembled SrTiO 3 nanocrystal photocatalyst was synthesized. → The molecular structure and chemical properties of hole scavengers affected H 2 production rate. → Formic acid exhibited the highest photocatalytic H 2 production enhancement ability. -- Abstract: The hydrogen production via the photocatalytic water splitting under UV irradiation using different compounds as hole scavengers (including methanol, formic acid, acetic acid, propanoic acid, hydrochloric acid, and sulfuric acid) under a low concentration range ( 3 nanocrystal photocatalyst. The results indicated that the hydrogen production efficiency greatly depended on the molecular structure, chemical properties, and concentration of the hole scavengers. Formic acid, which is the smallest and completely-dissociated water-soluble carboxylic acid, exhibited the highest hydrogen production enhancement ability. The 2.5 vol.% aqueous formic acid solution system provided the highest photocatalytic hydrogen production rate.

  15. Paramyxovirus Infection Mimics In Vivo Cellular Dynamics in Three-Demensional Human Bronchio-Epithelial Tissue-Like Assemblies

    Science.gov (United States)

    Deatly, Anne M.; Lin, Yen-Huei; McCarthy, Maureen; Chen, Wei; Miller, Lynn Z.; Quiroz, Jorge; Nowak, Becky M.; Lerch, Robert A.; Udem, Stephen A.; Goodwin, Thomas J.

    2012-01-01

    Respiratory syncytial virus and parainfluenza virus cause severe respiratory disease, especially in infants, children and the elderly. An in vitro model that accurately mimics infection of the human respiratory epithelium (HRE) would facilitate vaccine development greatly. Monolayer cultures traditionally used to study these viruses do not accurately and precisely differentiate the replication efficiencies of wild type and attenuated viruses. Therefore, we engineered novel three-dimensional (3D) tissue-like assemblies (TLAs) of human broncho-epithelial (HBE) cells to produce a more physiologically relevant in vitro model of the HRE. TLAs resemble HRE structurally and by expression of differentiated epithelial cell markers. Most significantly, wild type viruses exhibited a clear growth advantage over attenuated strains in TLAs unlike monolayer cultures. In addition, the TLAs responded to virus infection by secreting pro-inflammatory mediators similar to the respiratory epithelia of infected children. These characteristics make the TLA model a valuable platform technology to develop and evaluate live, attenuated respiratory virus vaccine candidates for human use. Respiratory virus diseases, the most frequent and least preventable of all infectious diseases, range in severity from the common cold to severe bronchiolitis and pneumonia . Two paramyxoviruses, respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3), are responsible for a majority of the most severe respiratory diseases of infants and young children. RSV causes 70% of all bronchiolitis cases and is a major cause of morbidity and mortality worldwide, especially in infants. PIV3 causes 10-15% of bronchiolitis and pneumonia during infancy, second only to RSV, and 40% of croup in infants To date, licensed vaccines are not available to prevent these respiratory diseases. At present, traditional monkey kidney (Vero and LLC-MK2) and human (HEp-2) tissue culture cells and small animal models (mouse

  16. Effect of Food Regulation on the Spanish Food Processing Industry: A Dynamic Productivity Analysis.

    Science.gov (United States)

    Kapelko, Magdalena; Oude Lansink, Alfons; Stefanou, Spiro E

    2015-01-01

    This article develops the decomposition of the dynamic Luenberger productivity growth indicator into dynamic technical change, dynamic technical inefficiency change and dynamic scale inefficiency change in the dynamic directional distance function context using Data Envelopment Analysis. These results are used to investigate for the Spanish food processing industry the extent to which dynamic productivity growth and its components are affected by the introduction of the General Food Law in 2002 (Regulation (EC) No 178/2002). The empirical application uses panel data of Spanish meat, dairy, and oils and fats industries over the period 1996-2011. The results suggest that in the oils and fats industry the impact of food regulation on dynamic productivity growth is negative initially and then positive over the long run. In contrast, the opposite pattern is observed for the meat and dairy processing industries. The results further imply that firms in the meat processing and oils and fats industries face similar impacts of food safety regulation on dynamic technical change, dynamic inefficiency change and dynamic scale inefficiency change.

  17. Effect of Food Regulation on the Spanish Food Processing Industry: A Dynamic Productivity Analysis

    Science.gov (United States)

    Kapelko, Magdalena; Lansink, Alfons Oude; Stefanou, Spiro E.

    2015-01-01

    This article develops the decomposition of the dynamic Luenberger productivity growth indicator into dynamic technical change, dynamic technical inefficiency change and dynamic scale inefficiency change in the dynamic directional distance function context using Data Envelopment Analysis. These results are used to investigate for the Spanish food processing industry the extent to which dynamic productivity growth and its components are affected by the introduction of the General Food Law in 2002 (Regulation (EC) No 178/2002). The empirical application uses panel data of Spanish meat, dairy, and oils and fats industries over the period 1996-2011. The results suggest that in the oils and fats industry the impact of food regulation on dynamic productivity growth is negative initially and then positive over the long run. In contrast, the opposite pattern is observed for the meat and dairy processing industries. The results further imply that firms in the meat processing and oils and fats industries face similar impacts of food safety regulation on dynamic technical change, dynamic inefficiency change and dynamic scale inefficiency change. PMID:26057878

  18. Development and use of dynamic product-line architectures

    NARCIS (Netherlands)

    Andersson, J; Bosch, J

    Software product families are used to shorten time-to-market, improve quality and lower cost, by means of effective reuse. The paper presents the results of case study conducted at four Swedish companies that are involved in either the development of or development with a software product family.

  19. Blood platelet production : optimization by dynamic programming and simulation

    NARCIS (Netherlands)

    Haijema, R.; Wal, van der J.; Dijk, van N.M.

    2007-01-01

    Blood platelets are precious, as voluntarily supplied by donors, and highly perishable, with limited lifetimes of 5–7 days. Demand is highly variable and uncertain. A practical production and inventory rule is strived for that minimizes shortages and spill. The demand and production are periodic, as

  20. Blood Platelet Production: Optimization by Dynamic Programming and Simulation

    NARCIS (Netherlands)

    Haijema, R.; Wal, van der J.; Dijk, van N.M.

    2007-01-01

    Blood platelets are precious, as voluntarily supplied by donors, and highly perishable, with limited lifetimes of 5¿7 days. Demand is highly variable and uncertain. A practical production and inventory rule is strived for that minimizes shortages and spill. The demand and production are periodic, as

  1. Field studies into the dynamics of product development tasks

    NARCIS (Netherlands)

    Oorschot, van K.E.; Bertrand, J.W.M.; Rutte, C.G.

    2005-01-01

    Purpose – This paper aims to describe three exploratory field studies investigating which characteristics add to later time to market and/or low product functionality of newly developed products. The studies are conducted at the level of developments tasks, or work packages. The first and second

  2. Sequence Identification, Recombinant Production, and Analysis of the Self-Assembly of Egg Stalk Silk Proteins from Lacewing Chrysoperla carnea.

    Science.gov (United States)

    Neuenfeldt, Martin; Scheibel, Thomas

    2017-06-13

    Egg stalk silks of the common green lacewing Chrysoperla carnea likely comprise at least three different silk proteins. Based on the natural spinning process, it was hypothesized that these proteins self-assemble without shear stress, as adult lacewings do not use a spinneret. To examine this, the first sequence identification and determination of the gene expression profile of several silk proteins and various transcript variants thereof was conducted, and then the three major proteins were recombinantly produced in Escherichia coli encoded by their native complementary DNA (cDNA) sequences. Circular dichroism measurements indicated that the silk proteins in aqueous solutions had a mainly intrinsically disordered structure. The largest silk protein, which we named ChryC1, exhibited a lower critical solution temperature (LCST) behavior and self-assembled into fibers or film morphologies, depending on the conditions used. The second silk protein, ChryC2, self-assembled into nanofibrils and subsequently formed hydrogels. Circular dichroism and Fourier transform infrared spectroscopy confirmed conformational changes of both proteins into beta sheet rich structures upon assembly. ChryC3 did not self-assemble into any morphology under the tested conditions. Thereby, through this work, it could be shown that recombinant lacewing silk proteins can be produced and further used for studying the fiber formation of lacewing egg stalks.

  3. Influence of Oxygenated Compounds on Reaction Products in a Microwave Plasma Methane Pyrolysis Assembly for Post-Processing of Sabatier Methane

    Science.gov (United States)

    Mansell, J. Matthew; Abney, Morgan B.

    2012-01-01

    The state-of-the-art Carbon Dioxide Reduction Assembly (CRA) was delivered to the International Space Station (ISS) in April 2010. The system is designed to accept carbon dioxide from the Carbon Dioxide Removal Assembly and hydrogen from the Oxygen Generation Assembly. The two gases are reacted in the CRA in a Sabatier reactor to produce water and methane. Venting of methane results in an oxygen resupply requirement of about 378 lbs per crew member per year. If the oxygen is supplied as water, the total weight for resupply is about 476 lb per crew member per year. For long-term missions beyond low Earth orbit, during which resupply capabilities will be further limited, recovery of hydrogen from methane is highly desirable. For this purpose, NASA is pursuing development of a Plasma Pyrolysis Assembly (PPA) capable of recovering hydrogen from methane. Under certain conditions, water vapor and carbon dioxide (nominally intended to be separated from the CRA outlet stream) may be present in the PPA feed stream. Thus, testing was conducted in 2010 to determine the effect of these oxygenated compounds on PPA performance, particularly the effect of inlet carbon dioxide and water variations on the PPA product stream. This paper discusses the test set-up, analysis, and results of this testing.

  4. Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

    Science.gov (United States)

    Grosse, Stefanie; Penaud-Budloo, Magalie; Herrmann, Anne-Kathrin; Börner, Kathleen; Fakhiri, Julia; Laketa, Vibor; Krämer, Chiara; Wiedtke, Ellen; Gunkel, Manuel; Ménard, Lucie; Ayuso, Eduard; Grimm, Dirk

    2017-10-15

    The discovery that adeno-associated virus 2 (AAV2) encodes an eighth protein, called assembly-activating protein (AAP), transformed our understanding of wild-type AAV biology. Concurrently, it raised questions about the role of AAP during production of recombinant vectors based on natural or molecularly engineered AAV capsids. Here, we show that AAP is indeed essential for generation of functional recombinant AAV2 vectors in both mammalian and insect cell-based vector production systems. Surprisingly, we observed that AAV2 capsid proteins VP1 to -3 are unstable in the absence of AAP2, likely due to rapid proteasomal degradation. Inhibition of the proteasome led to an increase of intracellular VP1 to -3 but neither triggered assembly of functional capsids nor promoted nuclear localization of the capsid proteins. Together, this underscores the crucial and unique role of AAP in the AAV life cycle, where it rapidly chaperones capsid assembly, thus preventing degradation of free capsid proteins. An expanded analysis comprising nine alternative AAV serotypes (1, 3 to 9, and rh10) showed that vector production always depends on the presence of AAP, with the exceptions of AAV4 and AAV5, which exhibited AAP-independent, albeit low-level, particle assembly. Interestingly, AAPs from all 10 serotypes could cross-complement AAP-depleted helper plasmids during vector production, despite there being distinct intracellular AAP localization patterns. These were most pronounced for AAP4 and AAP5, congruent with their inability to rescue an AAV2/AAP2 knockout. We conclude that AAP is key for assembly of genuine capsids from at least 10 different AAV serotypes, which has implications for vectors derived from wild-type or synthetic AAV capsids. IMPORTANCE Assembly of adeno-associated virus 2 (AAV2) is regulated by the assembly-activating protein (AAP), whose open reading frame overlaps with that of the viral capsid proteins. As the majority of evidence was obtained using virus

  5. Dynamics of actual aggregation of petroleum products in snow cover

    Science.gov (United States)

    Begunova, L. A.; Kuznetsova, O. V.; Begunov, D. A.; Kuznetsova, A. N.

    2017-11-01

    The paper presents issues of snow cover pollution by petroleum products. Petroleum products content was determined using the fluorimetric method of analysis. The samples of snow were selected on the territory of Angarsk and Irkutsk cities. According to the obtained data, the content of petroleum products in the analyzed samples exceeds the background value up to 6 times. Analysis of the reference data for similar research confirms need for creation of an environmental monitoring centralized system to monitor atmospheric precipitation and, particularly, snow cover.

  6. Modelling the dynamics of the health-production complex in livestock herds

    DEFF Research Database (Denmark)

    Sørensen, J.T.; Enevoldsen, Carsten

    1992-01-01

    This paper reviews how the dynamics of the health-production complex in livestock herds is mimicked by livestock herd simulation models. Twelve models simulating the dynamics of dairy, beef, sheep and sow herds were examined. All models basically included options to alter input and output...

  7. Exploring the dynamic and complex integration of sustainability performance measurement into product development

    DEFF Research Database (Denmark)

    Rodrigues, Vinicius Picanco; Morioka, S.; Pigosso, Daniela Cristina Antelmi

    2016-01-01

    In order to deal with the complex and dynamic nature of sustainability integration into the product development process, this research explore the use of a qualitative System Dynamics approach by using the causal loop diagram (CLD) tool. A literature analysis was followed by a case study, aiming ...

  8. Production of entropy on simplified dynamics in spin glass systems

    CERN Document Server

    Saakyan, D B

    2001-01-01

    In models of spin glasses one eliminates condition of extreme based on one of the order parameters. On the basis of the available expression for static sum one derived the effective hamiltonian for parameter and the appropriate energy. Relaxation of the system is studied as energy exchange between the degree of freedom related to the order slow parameter and with the rest of the system. At that level one may indicate point of glass capture within phase space on the basis of the static solutions. One studies p-spin model without magnetic field in case of replica symmetry violation. One studies dynamics of p-spin glass in magnetic field in replica-symmetrical phase. One studied model of spins with quadratic interaction when dynamic constants had temperature differing from temperature of space

  9. Production dynamics of fine roots in beech forests: possible mechanism of resource allocation between above- and below-ground production

    Science.gov (United States)

    Nakahata, R.; Osawa, A.; Naramoto, M.; Mizunaga, H.; Sato, M.

    2017-12-01

    The masting phenomenon that seed production has large annual variation with spatial synchrony appears generally in beeches. Therefore, net primary production and carbon allocation mechanism in beech forests may differ among several years in relation to annual variation of seed production. On the other hand, fine roots play key roles in carbon dynamics and nutrient and water acquisition of an ecosystem. Evaluation of fine root dynamics is essential to understand long-term dynamics of production in forest ecosystems. Moreover, the influence of mast seeding on resource allocation should be clarified in such beech forests. The aim of this study is to clarify possible relationships between the patterns of above- and below-ground production in relation to the masting events using observation data of litter fall and fine root dynamics. We applied the litter trap method and a minirhizotron method in a cool-temperate natural forest dominated by beech (Fagus crenata Blume). Ten litter traps were set from 2008 to 2016, then annual leaf and seed production were estimated. Four minirhizotron tubes were buried in Aug. 2008 and soil profiles were scanned monthly until Nov. 2016 during the periods of no snow covering. The scanned soil profiles were analyzed for calculating fine root production using the WinRHIZO Tron software. In the present study site, rich production of mast seeding occurred biennially and fine root production showed various seasonal patterns. There was no significant correlation between seed production and annual fine root production in the same year. However, seed production had a positive correlation with fine root production in autumn in the previous year and indicated a negative correlation with that in autumn in the current year. These results indicate that higher fine root production has led to increased nutrient acquisition, which resulted in rich seed production in the next year. It is also suppressed after the masting events due to shortage in

  10. Production system dynamism and parasitic interac- tion of swine in ...

    African Journals Online (AJOL)

    pasture and on swine with poor body condition compared to zero grazing, and on swine with ... Many countries practice different kinds of production approaches. ... farms with an average herd size of 29 swine were sampled by random sam-.

  11. Higher-Twist Dynamics in Large Transverse Momentum Hadron Production

    International Nuclear Information System (INIS)

    Francois, Alero

    2009-01-01

    A scaling law analysis of the world data on inclusive large-p # perpendicular# hadron production in hadronic collisions is carried out. A significant deviation from leading-twist perturbative QCD predictions at next-to-leading order is reported. The observed discrepancy is largest at high values of x # perpendicular# = 2p # perpendicular#/√s. In contrast, the production of prompt photons and jets exhibits the scaling behavior which is close to the conformal limit, in agreement with the leading-twist expectation. These results bring evidence for a non-negligible contribution of higher-twist processes in large-p # perpendicular# hadron production in hadronic collisions, where the hadron is produced directly in the hard subprocess rather than by gluon or quark jet fragmentation. Predictions for scaling exponents at RHIC and LHC are given, and it is suggested to trigger the isolated large-p # perpendicular# hadron production to enhance higher-twist processes.

  12. The role of electrostatics and temperature on morphological transitions of hydrogel nanostructures self-assembled by peptide amphiphiles via molecular dynamics simulations.

    Science.gov (United States)

    Fu, Iris W; Markegard, Cade B; Chu, Brian K; Nguyen, Hung D

    2013-10-01

    Smart biomaterials that are self-assembled from peptide amphiphiles (PA) are known to undergo morphological transitions in response to specific physiological stimuli. The design of such customizable hydrogels is of significant interest due to their potential applications in tissue engineering, biomedical imaging, and drug delivery. Using a novel coarse-grained peptide/polymer model, which has been validated by comparison of equilibrium conformations from atomistic simulations, large-scale molecular dynamics simulations are performed to examine the spontaneous self-assembly process. Starting from initial random configurations, these simulations result in the formation of nanostructures of various sizes and shapes as a function of the electrostatics and temperature. At optimal conditions, the self-assembly mechanism for the formation of cylindrical nanofibers is deciphered involving a series of steps: (1) PA molecules quickly undergo micellization whose driving force is the hydrophobic interactions between alkyl tails; (2) neighboring peptide residues within a micelle engage in a slow ordering process that leads to the formation of β-sheets exposing the hydrophobic core; (3) spherical micelles merge together through an end-to-end mechanism to form cylindrical nanofibers that exhibit high structural fidelity to the proposed structure based on experimental data. As the temperature and electrostatics vary, PA molecules undergo alternative kinetic mechanisms, resulting in the formation of a wide spectrum of nanostructures. A phase diagram in the electrostatics-temperature plane is constructed delineating regions of morphological transitions in response to external stimuli. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Seismic behaviour of fuel assembly

    Energy Technology Data Exchange (ETDEWEB)

    Song, Heuy Gap; Jhung, Myung Jo [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1993-11-01

    A general approach for the dynamic time-history analysis of the reactor core is presented in this paper as a part of the fuel assembly qualification program. Several detailed core models are set up to reflect the placement of the fuel assemblies within the core shroud. Peak horizontal responses are obtained for each model for the motions induced from earthquake. The dynamic responses such as fuel assembly shear force, bending moment and displacement, and spacer grid impact loads are carefully investigated. Also, the sensitivity responses are obtained for the earthquake motions and the fuel assembly non-linear response characteristics are discussed. (Author) 9 refs., 24 figs., 1 tab.

  14. Bacteriophage Assembly

    Directory of Open Access Journals (Sweden)

    Anastasia A. Aksyuk

    2011-02-01

    Full Text Available Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors. The sequence and molecular mechanisms of phage assembly have been elucidated by a variety of methods. Differences and similarities of assembly processes in several different groups of bacteriophages are discussed in this review. The general principles of phage assembly are applicable to many macromolecular complexes.

  15. Sequence assembly

    DEFF Research Database (Denmark)

    Scheibye-Alsing, Karsten; Hoffmann, S.; Frankel, Annett Maria

    2009-01-01

    Despite the rapidly increasing number of sequenced and re-sequenced genomes, many issues regarding the computational assembly of large-scale sequencing data have remain unresolved. Computational assembly is crucial in large genome projects as well for the evolving high-throughput technologies and...... in genomic DNA, highly expressed genes and alternative transcripts in EST sequences. We summarize existing comparisons of different assemblers and provide a detailed descriptions and directions for download of assembly programs at: http://genome.ku.dk/resources/assembly/methods.html....

  16. Dynamic optimization approach for integrated supplier selection and tracking control of single product inventory system with product discount

    Science.gov (United States)

    Sutrisno; Widowati; Heru Tjahjana, R.

    2017-01-01

    In this paper, we propose a mathematical model in the form of dynamic/multi-stage optimization to solve an integrated supplier selection problem and tracking control problem of single product inventory system with product discount. The product discount will be stated as a piece-wise linear function. We use dynamic programming to solve this proposed optimization to determine the optimal supplier and the optimal product volume that will be purchased from the optimal supplier for each time period so that the inventory level tracks a reference trajectory given by decision maker with minimal total cost. We give a numerical experiment to evaluate the proposed model. From the result, the optimal supplier was determined for each time period and the inventory level follows the given reference well.

  17. Welding facilities for NPP assembling

    International Nuclear Information System (INIS)

    Rojtenberg, S.S.

    1987-01-01

    Recommendations concerning the choice of equipment for welding in pre-assembling work shops, in the enlarging assembling shops and at the assembling site, are given. Advanced production automatic welders and semiautomatic machines, applied during the NPP equipment assembling as well as automatic machines specially produced for welding the main reactor components and pipelines are described. Automatic and semiautomatic machine and manual welding post supply sources are considered

  18. Effect of the nitrogen incorporation and fast carrier dynamics in (In,Ga)AsN/GaP self-assembled quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, J.-P.; Almosni, S.; Léger, Y.; Perrin, M.; Even, J.; Cornet, C., E-mail: charles.cornet@insa-rennes.fr; Durand, O. [UMR FOTON, CNRS, INSA-Rennes, F-35708 Rennes (France); Robert, C. [Tyndall National Institute, University College Cork, Lee Maltings, Cork (Ireland); Balocchi, A.; Carrère, H.; Marie, X. [Université de Toulouse, INSA-CNRS-UPS, LPCNO, F-31077 Toulouse (France)

    2014-12-15

    We report on the structural and optical properties of (In,Ga)AsN self-assembled quantum dots grown on GaP (001) substrate. A comparison with nitrogen free (In,Ga)As system is presented, showing a clear modification of growth mechanisms and a significant shift of the photoluminescence spectrum. Low temperature carrier recombination dynamics is studied by time-resolved photoluminescence, highlighting a drastic reduction of the characteristic decay-time when nitrogen is incorporated in the quantum dots. Room temperature photoluminescence is observed at 840 nm. These results reveal the potential of (In,Ga)AsN as an efficient active medium monolithically integrated on Si for laser applications.

  19. Production and Testing of Kiln-cast Glass Components for an Interlocking, Dry-assembled Transparent Bridge

    NARCIS (Netherlands)

    Bristogianni, T.; Oikonomopoulou, F.; Veer, F.A.; Snijder, A.H.; Nijsse, R.

    A pedestrian glass bridge, located at the TU Delft campus site, is being designed by the TU Delft Glass & Transparency Lab. Specifically, the arch-formed bridge consists of cast glass, dry-assembled, interlocking components. To validate the shape of the components, glass mock-ups in 1:2 scale

  20. Dynamics of ethylene production in response to compatible Nod factor

    DEFF Research Database (Denmark)

    Reid, Dugald; Liu, Huijun; Kelly, Simon

    2018-01-01

    Establishment of symbiotic nitrogen-fixation in legumes is regulated by the plant hormone ethylene, but it has remained unclear whether and how its biosynthesis is regulated by the symbiotic pathway. We established a sensitive ethylene detection system for Lotus japonicus and found that ethylene...... production increased as early as six hours after inoculation with Mesorhizobium loti. This ethylene response was dependent on Nod factor production by compatible rhizobia. Analyses of nodulation mutants showed that perception of Nod factor was required for ethylene emission, while downstream transcription...... factors including CYCLOPS, NIN and ERN1 were not required for this response. Activation of the nodulation signalling pathway in spontaneously nodulating mutants was also sufficient to elevate ethylene production. Ethylene signalling is controlled by EIN2, which is duplicated in L. japonicus. We obtained...

  1. Laser Pulse Production for NASA's Global Ecosystem Dynamics Investigation (GEDI) Lidar

    Science.gov (United States)

    Stysley, Paul R.; Coyle, D. Barry; Clarke, Greg B.; Frese, Erich; Blalock, Gordon; Morey, Peter; Kay, Richard B.; Poulios, Demetrios; Hersh, Michael

    2016-01-01

    The Lasers and Electro-Optics Branch at Goddard Space Flight Center has been tasked with building the Lasers for the Global Ecosystems Dynamics Investigation (GEDI) Lidar Mission, to be installed on the Japanese Experiment Module (JEM) on the International Space Station (ISS)1. GEDI will use three NASA-developed lasers, each coupled with a Beam Dithering Unit (BDU) to produce three sets of staggered footprints on the Earth's surface to accurately measure global biomass. We will report on the design, assembly progress, test results, and delivery process of this laser system.

  2. Weak decays and the dynamics of heavy quark production

    International Nuclear Information System (INIS)

    Milani, P.

    1980-02-01

    The parent-child relation governing the yield of particles arising from the subsequent decay of primarily-produced hadrons is investigated in the high-Psub(T) regime. An approximation scheme is developed and applied to the study of leptons and kaons coming from charged mesons produced in hadronic collisions. Correlations of the final particles are considered and a generalised Sternheimer relation, whereby given the moments of the decay distribution, the parent correlations may be simply extracted from the decay products, is developed. Finally the predictions of QCD for heavy quark production as observed through their weak decays, are investigated. (author)

  3. Jet production and the dynamical role of color

    International Nuclear Information System (INIS)

    Brodsky, S.J.

    1977-05-01

    It is discussed how multiparticle jets which originate from quarks, multiquarks, hadrons, or gluons can be distinguished by their quantum number retention, leading particle distributions, and hadronic multiplicity. The possible quantitative connection between initial color separation and hadron multiplicity is emphasized. Evidence for wee quark exchange as a dominant hadronic mechanism is presented. Also discussed are several new mechanisms for gluon jet production. Finally, the possibility of utilizing a high multiplicity trigger to expose gluon exchange and production contributions in hadron- and lepton-induced reactions are considered

  4. A dynamic model for managing overlapped iterative product development

    NARCIS (Netherlands)

    Lin, J.; Chai, K.H.; Wong, Y.S.; Brombacher, A.C.

    2008-01-01

    Intense competition in many industries impels firms to develop more products in less time. Overlapping of development activities is regarded as one of the most promising strategies to reduce project cycle time. However, the gain from overlapping must be weighed against the additional resource and

  5. Dynamical regimes due to technological change in a microeconomical model of production

    Science.gov (United States)

    Hamacher, K.

    2012-09-01

    We develop a microeconomical model to investigate the impact of technological change onto production decisions of suppliers—modeling an effective feedback mechanism of the market. An important property—the time horizon of production planning—is related to the Kolmogorov entropy of the one-dimensional maps describing price dynamics. We simulate this price dynamics in an ensemble representing the whole macroeconomy. We show how this model can be used to support ongoing research in economic growth and incorporate the obtained microeconomic findings into the discussion about appropriate macroeconomic quantities such as the production function—thus effectively underpinning macroeconomics with microeconomical dynamics. From there we can show that the model exhibits different dynamical regimes (suggesting "phase transitions") with respect to an order parameter. The non-linear feedback under technological change was found to be the crucial mechanism. The implications of the obtained regimes are finally discussed.

  6. Properties of Molecular organized assemblies at interfaces

    Indian Academy of Sciences (India)

    Dr.AURNA

    Organized molecular assemblies. An organized molecular assembly is a group of atoms or ..... Simulations of the growth of clusters on a .... dynamics and function. ➢Actively ... Study of amphiphilic derivatives of YIGSR, mutated at hyper active ...

  7. Evaluating social science and humanities knowledge production: An exploratory analysis of dynamics in science systems

    NARCIS (Netherlands)

    van Hemert, P.P.; Nijkamp, P.; Verbraak, J.

    2009-01-01

    Knowledge is gaining increasing importance in modern-day society as a factor of production and, ultimately, growth. This article explores the dynamics in university knowledge production and its effect on the state of university-industry-policy exchange in the Netherlands. Science systems are said to

  8. Decomposition principles applied to the dynamic production and work-force scheduling problem

    NARCIS (Netherlands)

    Aardal, K.I.; Ari, A.

    1987-01-01

    One of the most important problems in the production and inventory planning field, is the scheduling of production and work force in a dynamic environment. Although this problem can be formulated as a linear program, it is often quite difficult to solve directly, due to its large scale. Instead, it

  9. Study the nature of changes in the dynamic viscosity of milk and fruit products

    Directory of Open Access Journals (Sweden)

    A. N. Ostrikov

    2013-01-01

    Full Text Available The variation of the dynamic viscosity of dairy products and fruit puree with the free run-off on the vertical wall of the vacuum chamber with a two-stage vacuum evaporation was studied. The effect of evaporation temperature and product moisture on the rheological properties of milk and fruit blends was investigated.

  10. Dynamic effects of social influence and direct marketing on the adoption of high-technology products

    NARCIS (Netherlands)

    Risselada, H.; Verhoef, P.C.; Bijmolt, T.H.A.

    Many firms capitalize on their customers' social networks to improve the success rate of their new products. In this article, the authors analyze the dynamic effects of social influence and direct marketing on the adoption of a new high-technology product. Social influence is likely to play a role

  11. Primary production, nutrient dynamics and mineralisation in a northeastern Greenland fjord during the summer thaw

    DEFF Research Database (Denmark)

    Rysgaard, S.; Finster, K.; Dahlgaard, H.

    1996-01-01

    This investigation represents the first integrated study of primary production, nutrient dynamics and mineralisation in a northeastern fjord of Greenland. The data presented represent conditions and activities during the early summer thaw (first 2 weeks of July). Primary production (5.3 mmol C m(...

  12. Hydrogen production from water splitting over Eosin Y-sensitized mesoporous-assembled perovskite titanate nanocrystal photocatalysts under visible light irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Puangpetch, Tarawipa [Department of Chemical Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom 73000 (Thailand); Sommakettarin, Pichayaon [The Petroleum and Petrochemical College, Chulalongkorn University, Soi Chula 12, Phyathai Road, Pathumwan, Bangkok 10330 (Thailand); Chavadej, Sumaeth; Sreethawong, Thammanoon [The Petroleum and Petrochemical College, Chulalongkorn University, Soi Chula 12, Phyathai Road, Pathumwan, Bangkok 10330 (Thailand); Center for Petroleum, Petrochemicals, and Advanced Materials, Chulalongkorn University, Bangkok 10330 (Thailand)

    2010-11-15

    The photocatalytic water splitting is a promising process for producing H{sub 2} from two abundant renewable sources of water and solar light, with the aid of a suitable photocatalyst. In this work, a combination of sensitizer addition and noble metal loading was employed to modify perovskite photocatalysts in order to achieve the enhancement of photocatalytic H{sub 2} production under visible light irradiation. The dependence of the H{sub 2} production on type of mesoporous-assembled perovskite titanate nanocrystal photocatalysts (MgTiO{sub 3}, CaTiO{sub 3}, and SrTiO{sub 3}), calcination temperature of photocatalyst, Pt loading, type and concentration of electron donor (diethanolamine, DEA; and triethanolamine, TEA), concentration of sensitizer (Eosin Y, E.Y.), photocatalyst dosage, and initial solution pH, was systematically studied. The experimental results showed that the 0.5 wt.% Pt-loaded mesoporous-assembled SrTiO{sub 3} nanocrystal synthesized by a single-step sol-gel method and calcined at 650 C exhibited the highest photocatalytic H{sub 2} production activity from a 15 vol% DEA aqueous solution with dissolved 0.5 mM E.Y. Moreover, the optimum photocatalyst dosage and initial solution pH for the maximum photocatalytic H{sub 2} production activity were found to be 6 g/l and 11.6, respectively. (author)

  13. Non-equilibrium Dynamics, Thermalization and Entropy Production

    International Nuclear Information System (INIS)

    Hinrichsen, Haye; Janotta, Peter; Gogolin, Christian

    2011-01-01

    This paper addresses fundamental aspects of statistical mechanics such as the motivation of a classical state space with spontaneous transitions, the meaning of non-equilibrium in the context of thermalization, and the justification of these concepts from the quantum-mechanical point of view. After an introductory part we focus on the problem of entropy production in non-equilibrium systems. In particular, the generally accepted formula for entropy production in the environment is analyzed from a critical perspective. It is shown that this formula is only valid in the limit of separated time scales of the system's and the environmental degrees of freedom. Finally, we present an alternative simple proof of the fluctuation theorem.

  14. Modeling the Potential Effects of New Tobacco Products and Policies: A Dynamic Population Model for Multiple Product Use and Harm

    Science.gov (United States)

    Vugrin, Eric D.; Rostron, Brian L.; Verzi, Stephen J.; Brodsky, Nancy S.; Brown, Theresa J.; Choiniere, Conrad J.; Coleman, Blair N.; Paredes, Antonio; Apelberg, Benjamin J.

    2015-01-01

    Background Recent declines in US cigarette smoking prevalence have coincided with increases in use of other tobacco products. Multiple product tobacco models can help assess the population health impacts associated with use of a wide range of tobacco products. Methods and Findings We present a multi-state, dynamical systems population structure model that can be used to assess the effects of tobacco product use behaviors on population health. The model incorporates transition behaviors, such as initiation, cessation, switching, and dual use, related to the use of multiple products. The model tracks product use prevalence and mortality attributable to tobacco use for the overall population and by sex and age group. The model can also be used to estimate differences in these outcomes between scenarios by varying input parameter values. We demonstrate model capabilities by projecting future cigarette smoking prevalence and smoking-attributable mortality and then simulating the effects of introduction of a hypothetical new lower-risk tobacco product under a variety of assumptions about product use. Sensitivity analyses were conducted to examine the range of population impacts that could occur due to differences in input values for product use and risk. We demonstrate that potential benefits from cigarette smokers switching to the lower-risk product can be offset over time through increased initiation of this product. Model results show that population health benefits are particularly sensitive to product risks and initiation, switching, and dual use behaviors. Conclusion Our model incorporates the variety of tobacco use behaviors and risks that occur with multiple products. As such, it can evaluate the population health impacts associated with the introduction of new tobacco products or policies that may result in product switching or dual use. Further model development will include refinement of data inputs for non-cigarette tobacco products and inclusion of health

  15. Analysis of the dynamic response of a double rupture disc assembly to simulated sodium-water reaction pressure pulses

    International Nuclear Information System (INIS)

    Leonard, J.R.

    1980-03-01

    A series of double rupture disc experiments were conducted in 1979 to evaluate the dynamic response characteristics of this pressure relief apparatus. The tests were performed in a facility with water simulating sodium and rising pressure pulses representative of the pressure increase resulting from a water/steam leak from a steam generator into sodium in the intermediate heat transport system of a breeder reactor power plant. Maximum source pressures ranged in magnitude from 50 psi to 800 psi. Dynamic response characteristics of each of the two rupture discs were similar to those observed in larger scale sodium-water experiments conducted in the Series I and Series II Large Leak Test Program at the Energy Technology Engineering Center. The SRI double rupture disc dynamic behavior was found to be consistent and amendable to modelling in the TRANSWRAP II computer code. A series of correlations which represent rupture disc buckling parameters were developed for use in the TRANSWRAP II code. The semi-empirical modeling of the rupture discs in the TRANSWRAP II code showed very good agreement with the experimental results

  16. Dynamics of a Bertrand duopoly with differentiated products and nonlinear costs: Analysis, comparisons and new evidences

    International Nuclear Information System (INIS)

    Brianzoni, Serena; Gori, Luca; Michetti, Elisabetta

    2015-01-01

    This paper studies mathematical properties and dynamics of a duopoly with price competition and horizontal product differentiation by introducing quadratic production costs (decreasing returns to scale), thus extending the model with linear costs (constant returns to scale) of Fanti et al. [11]. The economy is described by a two-dimensional non-invertible discrete time dynamic system. The paper first determines fixed points and other invariant sets, showing that synchronized dynamics can occur. Then, stability properties are compared in the cases of quadratic costs and linear costs by considering the degree of product differentiation and the speed of adjustment of prices as key parameters. It is also shown that synchronization takes place if products tend to be relatively complements and stressed similarities and differences between models with quadratic and linear costs. Finally, the paper focuses on the phenomenon of multistability thus underlying new evidences in comparison with the model with linear costs.

  17. Self-assembled 3D flower-like Ni2+-Fe3+ layered double hydroxides and their calcined products

    International Nuclear Information System (INIS)

    Xiao Ting; Tang Yiwen; Jia Zhiyong; Li Dawei; Hu Xiaoyan; Li Bihui; Luo Lijuan

    2009-01-01

    This paper describes a facile solvothermal method to synthesize self-assembled three-dimensional (3D) Ni 2+ -Fe 3+ layered double hydroxides (LDHs). Flower-like Ni 2+ -Fe 3+ LDHs constructed of thin nanopetals were obtained using ethylene glycol (EG) as a chelating reagent and urea as a hydrolysis agent. The reaction mechanism and self-assembly process are discussed. After calcinating the as-prepared LDHs at 450 0 C in nitrogen gas, porous NiO/NiFe 2 O 4 nanosheets were obtained. This work resulted in the development of a simple, cheap, and effective route for the fabrication of large area Ni 2+ -Fe 3+ LDHs as well as porous NiO/NiFe 2 O 4 nanosheets.

  18. Process development for automated solar-cell and module production. Task 4. Automated array assembly. Quarterly report No. 3

    Energy Technology Data Exchange (ETDEWEB)

    Hagerty, J. J.; Gifford, M.

    1981-04-15

    The Automated Lamination Station is mechanically complete and is currently undergoing final wiring. The high current driver and isolator boards have been completed and installed, and the main interface board is under construction. The automated vacuum chamber has had a minor redesign to increase stiffness and improve the cover open/close mechanism. Design of the Final Assembly Station has been completed and construction is underway.

  19. A Market Dynamics Model for New Industrial Products and Its Application

    OpenAIRE

    Shmuel S. Oren; Michael H. Rothkopf

    1984-01-01

    New product planning models attempt to predict the market consequences of product line and product design decisions. One output of such models, especially those driven by subjective or market research data, is usually theoretical market shares based upon consumer preferences under idealized conditions. This paper describes a class of models that bridge the gap between such theoretical market shares and dynamic sales forecasts. This model accounts for differences in customer awareness of diffe...

  20. Colour dynamics in large psub(T) hadron production on nuclei

    International Nuclear Information System (INIS)

    Kopeliovich, B.Z.; Niedermayer, F.

    1984-01-01

    The color dynamics of hadron production with large transverse momentum (psub(T)) on nuclei is investigated. Retardation by colour forces of colour objects propagating through nuclear matter leads to considerable shadowing of hard processes inside the nucleus. This explains the weak A dependence of the production cross section for large psub(T) meson pairs. The small absorption of compressed hadronic configurations inside the nucleus explains the linear A dependence of pp-pair production

  1. To Capture Dynamic Shop Floor Knowledge in Global Production Networks

    DEFF Research Database (Denmark)

    Madsen, Erik Skov; Riis, Jens Ove; Sørensen, Brian Vejrum

    2007-01-01

    ­ing of the jobs to be transferred and has led to a changed focus for training new workers. Secondly, the paper will address how to capture the knowl­edge associated with carrying out these jobs. And third, planning the trans­fer process will be discussed to form a basis for future continuous improve...... industrial companies with plans to transfer production units to an­other location, this paper addresses  the initial steps of pursuing this issue by presenting and testing a model for identification of the activities, task and  knowledge on the shop floor jobs. This has provided a broader understand...

  2. Novel and facile method, dynamic self-assemble, to prepare SnO₂/rGO droplet aerogel with complex morphologies and their application in supercapacitors.

    Science.gov (United States)

    Chen, Mingxi; Wang, Huan; Li, Lingzhi; Zhang, Zhe; Wang, Cong; Liu, Yu; Wang, Wei; Gao, Jianping

    2014-08-27

    A facile and novel method to prepare SnO2/reduced graphene oxide (rGO) droplet aerogels with complex morphologies had been developed. This method has been named dynamic self-assemble. Aerogels with both "egg-tart" and "mushroom" shapes were obtained by this method. The changes in the graphene oxide (GO) droplet morphologies during the dynamic process of a GO droplet falling into a SnCl2 target solution were monitored using a high speed camera. The formed SnO2/rGO aerogels were then characterized by Raman spectroscopy, thermogravimetric analysis, X-ray diffraction analysis, and X-ray photoelectron spectroscopy. The microstructures of the SnO2/rGO aerogels were observed with scanning electron microscopy and transmission electron microscopy. Finally, the SnO2/rGO droplet aerogels were used as the electrode material in a symmetrical two-electrode supercapacitor and the electrochemical performance of the supercapacitor was investigated using cyclic voltammetry and galvanostatic charge/discharge methods. The SnO2/rGO electrodes demonstrated excellent electrochemical performance and stability. At a scan rate of 5 mV/s, their highest gravimetric and volumetric specific capacitances were 310 F/g and 180 F/cm(3), respectively, and their energy and power densities were as high as 30 Wh·kg(-1) and 8.3 kW·kg(-1), respectively.

  3. Effect of Vaginal or Systemic Estrogen on Dynamics of Collagen Assembly in the Rat Vaginal Wall1

    Science.gov (United States)

    Montoya, T. Ignacio; Maldonado, P. Antonio; Acevedo, Jesus F.; Word, R. Ann

    2014-01-01

    ABSTRACT The objective of this study was to compare the effects of systemic and local estrogen treatment on collagen assembly and biomechanical properties of the vaginal wall. Ovariectomized nulliparous rats were treated with estradiol or conjugated equine estrogens (CEEs) either systemically, vaginal CEE, or vaginal placebo cream for 4 wk. Low-dose local CEE treatment resulted in increased vaginal epithelial thickness and significant vaginal growth without uterine hyperplasia. Furthermore, vaginal wall distensibility increased without compromise of maximal force at failure. Systemic estradiol resulted in modest increases in collagen type I with no change in collagen type III mRNA. Low-dose vaginal treatment, however, resulted in dramatic increases in both collagen subtypes whereas moderate and high dose local therapies were less effective. Consistent with the mRNA results, low-dose vaginal estrogen resulted in increased total and cross-linked collagen content. The inverse relationship between vaginal dose and collagen expression may be explained in part by progressive downregulation of estrogen receptor-alpha mRNA with increasing estrogen dose. We conclude that, in this menopausal rat model, local estrogen treatment increased total and cross-linked collagen content and markedly stimulated collagen mRNA expression in an inverse dose-effect relationship. High-dose vaginal estrogen resulted in downregulation of estrogen receptor-alpha and loss of estrogen-induced increases in vaginal collagen. These results may have important clinical implications regarding the use of local vaginal estrogen therapy and its role as an adjunctive treatment in women with loss of vaginal support. PMID:25537371

  4. Thermodynamic of the associated cycle and application to the assembly of thermochemical iodine sulphur cycle and a nuclear engine for the hydrogen production

    International Nuclear Information System (INIS)

    Dumont, Y.

    2008-01-01

    This thesis is devoted to the design of an assembly of a hydrogen production process by the thermochemical iodine-sulphur cycle and a nuclear reactor. The suggested coupling network uses a power cycle which produces a work which is directly used for the heat pump running. The purpose of this thermodynamic cycle association is to recover the rejected energy at low temperature of a process to provide the energy needs of this same process at high temperature. This association is applied to the studied coupling. The construction of the energy distribution network is designed by the pinch analysis. In the case of a conventional coupling, the efficiency of hydrogen production is 22.0%. By integrating the associated cycles into the coupling, the efficiency of production is 42.6%. The exergetic efficiency, representative of the energy using quality, increases from 58.7% to 85.4%. (author) [fr

  5. Lageos assembly operation plan

    Science.gov (United States)

    Brueger, J.

    1975-01-01

    Guidelines and constraints procedures for LAGEOS assembly, operation, and design performance are given. Special attention was given to thermal, optical, and dynamic analysis and testing. The operation procedures illustrate the interrelation and sequence of tasks in a flow diagram. The diagram also includes quality assurance functions for verification of operation tasks.

  6. Assembly of primary cilia

    DEFF Research Database (Denmark)

    Pedersen, Lotte B; Veland, Iben R; Schrøder, Jacob M

    2008-01-01

    knowledge about IFT is based on studies performed in Chlamydomonas and Caenorhabditis elegans. Therefore, our review of the IFT literature includes studies performed in these two model organisms. The role of several non-IFT proteins (e.g., centrosomal proteins) in the ciliary assembly process is also...... discussed. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc....

  7. Dynamic Determinants of Korean Productivity Changes: with Emphasis on Trade

    Directory of Open Access Journals (Sweden)

    Sangho Kim

    2005-12-01

    Full Text Available This study investigates the relationship between trade and economic growth in Korea during the period 1980~2003. The empirical results suggest the existence of Granger causality running from imports to total factor productivity (TFP growth, and the relatively weak causal relationship between exports and TFP. In light of this causal relationship between imports and TFP growth, TFP growth is regressed on various trade variables, along with R&D investments and government size. The results indicate that imports have significant positive effects on TFP but that exports do not. The results also indicate that the salutary impact of imports on TFP growth stems not only from competitive pressure and new knowledge acquired from foreign rivals in the context of increased imports of final goods but also from technological transfers embodied by imports from developed countries. Most of the empirical results still hold when TFP growth is replaced with GDP growth.

  8. Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

    OpenAIRE

    Mol, Clifford D.; Brooun, Alexei; Dougan, Douglas R.; Hilgers, Mark T.; Tari, Leslie W.; Wijnands, Robert A.; Knuth, Mark W.; McRee, Duncan E.; Swanson, Ronald V.

    2003-01-01

    UDP-N-acetylmuramic acid:l-alanine ligase (MurC) catalyzes the addition of the first amino acid to the cytoplasmic precursor of the bacterial cell wall peptidoglycan. The crystal structures of Haemophilus influenzae MurC in complex with its substrate UDP-N-acetylmuramic acid (UNAM) and Mg2+ and of a fully assembled MurC complex with its product UDP-N-acetylmuramoyl-l-alanine (UMA), the nonhydrolyzable ATP analogue AMPPNP, and Mn2+ have been determined to 1.85- and 1.7-Å resolution, respective...

  9. Cooperative assembly of Co-Smad4 MH1 with R-Smad1/3 MH1 on DNA: a molecular dynamics simulation study.

    Directory of Open Access Journals (Sweden)

    Guihong Wang

    Full Text Available Smads, the homologs of Sma and MAD proteins, play a key role in gene expression regulation in the transforming growth factor-β (TGF-β signaling pathway. Recent experimental studies have revealed that Smad4/R-Smad heterodimers bound on DNA are energetically more favorable than homodimeric R-Smad/R-Smad complexes bound on DNA, which indicates that Smad4 might act as binding vehicle to cooperatively assemble with activated R-Smads on DNA in the nucleus. However, the details of interaction mechanism for cooperative recruitment of Smad4 protein to R-Smad proteins on DNA, and allosteric communication between the Smad4-DNA and R-Smad-DNA interfaces via DNA mediating are not yet clear so far.In the present work, we have constructed a series of Smadn+DNA+Smadn (n = 1, 3, 4 models and carried out molecular dynamics simulations, free energy calculations and DNA dynamics analysis for them to study the interaction properties of Smadn (n = 1, 3, 4 with DNA molecule.The results revealed that the binding of Smad4 protein to DNA molecule facilitates energetically the formation of the heteromeric Smad4+DNA+Smad1/3 complex by increasing the affinity of Smad1/3 with DNA molecule. Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations. The present work theoretically explains the mechanism of cooperative recruitment of Smad4 protein to Smad1/3 protein via DNA-mediated indirect readout mode in the nucleus.

  10. Science dynamics and research production indicators, indexes, statistical laws and mathematical models

    CERN Document Server

    Vitanov, Nikolay K

    2016-01-01

    This book deals with methods to evaluate scientific productivity. In the book statistical methods, deterministic and stochastic models and numerous indexes are discussed that will help the reader to understand the nonlinear science dynamics and to be able to develop or construct systems for appropriate evaluation of research productivity and management of research groups and organizations. The dynamics of science structures and systems is complex, and the evaluation of research productivity requires a combination of qualitative and quantitative methods and measures. The book has three parts. The first part is devoted to mathematical models describing the importance of science for economic growth and systems for the evaluation of research organizations of different size. The second part contains descriptions and discussions of numerous indexes for the evaluation of the productivity of researchers and groups of researchers of different size (up to the comparison of research productivities of research communiti...

  11. Probing the Energetics of Dynactin Filament Assembly and the Binding of Cargo Adaptor Proteins Using Molecular Dynamics Simulation and Electrostatics-Based Structural Modeling.

    Science.gov (United States)

    Zheng, Wenjun

    2017-01-10

    Dynactin, a large multiprotein complex, binds with the cytoplasmic dynein-1 motor and various adaptor proteins to allow recruitment and transportation of cellular cargoes toward the minus end of microtubules. The structure of the dynactin complex is built around an actin-like minifilament with a defined length, which has been visualized in a high-resolution structure of the dynactin filament determined by cryo-electron microscopy (cryo-EM). To understand the energetic basis of dynactin filament assembly, we used molecular dynamics simulation to probe the intersubunit interactions among the actin-like proteins, various capping proteins, and four extended regions of the dynactin shoulder. Our simulations revealed stronger intersubunit interactions at the barbed and pointed ends of the filament and involving the extended regions (compared with the interactions within the filament), which may energetically drive filament termination by the capping proteins and recruitment of the actin-like proteins by the extended regions, two key features of the dynactin filament assembly process. Next, we modeled the unknown binding configuration among dynactin, dynein tails, and a number of coiled-coil adaptor proteins (including several Bicaudal-D and related proteins and three HOOK proteins), and predicted a key set of charged residues involved in their electrostatic interactions. Our modeling is consistent with previous findings of conserved regions, functional sites, and disease mutations in the adaptor proteins and will provide a structural framework for future functional and mutational studies of these adaptor proteins. In sum, this study yielded rich structural and energetic information about dynactin and associated adaptor proteins that cannot be directly obtained from the cryo-EM structures with limited resolutions.

  12. Dynamic Pricing of New Products in Competitive Markets: A Mean-Field Game Approach

    OpenAIRE

    Chenavaz, Régis; Paraschiv, Corina; Turinici, Gabriel

    2017-01-01

    Dynamic pricing of new products has been extensively studied in monopolistic and oligopolistic markets. But, the optimal control and differential game tools used to investigate the pricing behavior on markets with a finite number of firms are not well-suited to model competitive markets with an infinity of firms. Using a mean-field games approach, this paper examines dynamic pricing policies in competitive markets, where no firm exerts market power. The theoretical setting is based on a diffu...

  13. Fuel assembly

    International Nuclear Information System (INIS)

    Nakajima, Akiyoshi; Bessho, Yasunori; Aoyama, Motoo; Koyama, Jun-ichi; Hirakawa, Hiromasa; Yamashita, Jun-ichi; Hayashi, Tatsuo

    1998-01-01

    In a fuel assembly of a BWR type reactor in which a water rod of a large diameter is disposed at the central portion, the cross sectional area perpendicular to the axial direction comprises a region a of a fuel rod group facing to a wide gap water region to which a control rod is inserted, a region b of a fuel rod group disposed on the side of the wide gap water region other than the region a, a region d of a fuel rod group facing to a narrow gap water region and a region c of a fuel rod group disposed on the side of the narrow gap water region other than the region d. When comparing an amount of fission products contained in the four regions relative to that in the entire regions and average enrichment degrees of fuel rods for the four regions, the relative amount and the average enrichment degree of the fuel rod group of the region a is minimized, and the relative amount and the average enrichment degree of the fuel rod group in the region b is maximized. Then, reactor shut down margin during cold operation can be improved while flattening the power in the cross section perpendicular to the axial direction. (N.H.)

  14. Dynamic Game Behavior of Retailers Considering the Quality of Substitute Products Based on Delay Decision

    Science.gov (United States)

    Bao, Binshuo; Ma, Junhai

    2017-12-01

    Motivated by the Silk Road Economic Belt and the 21st-Century Maritime Silk Road project, i.e. the Belt and Road (B&R), more goods will flow around the world. With this trading platform, people can buy products at relatively cheap prices, and it is easier for people to buy various goods. The quality and quantity of products thus attract more and more attention in the supply chains. This paper discusses the quantity decision by considering the product quality in parallel supply chains where two manufacturers produce substitute products and then sell them to their downstream retailers separately. In terms of the changing quantity, as well as the different quality, this paper establishes a dynamic game model to explore the dynamic behavior when the optimal profits of two retailers have been calculated. The dynamic behaviors of the system, such as stable region, bifurcation and chaos, strange attractors and the largest Lyapunov exponents (LLE) are analyzed. The effect of the quantity adjustment parameter on the stability of the supply chain system is investigated through numerical simulations. Furthermore, a dynamic game model is established based on the quality delay decision, to investigate the influence of the quality delay parameter on the dynamic game model and the profits. Finally, the optimal decisions are obtained and analyzed.

  15. A thiol-disulfide oxidoreductase of the Gram-positive pathogen Corynebacterium diphtheriae is essential for viability, pilus assembly, toxin production and virulence.

    Science.gov (United States)

    Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Jooya, Neda; Chang, Chungyu; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung

    2015-12-01

    The Gram-positive pathogen Corynebacterium diphtheriae exports through the Sec apparatus many extracellular proteins that include the key virulence factors diphtheria toxin and the adhesive pili. How these proteins attain their native conformations after translocation as unfolded precursors remains elusive. The fact that the majority of these exported proteins contain multiple cysteine residues and that several membrane-bound oxidoreductases are encoded in the corynebacterial genome suggests the existence of an oxidative protein-folding pathway in this organism. Here we show that the shaft pilin SpaA harbors a disulfide bond in vivo and alanine substitution of these cysteines abrogates SpaA polymerization and leads to the secretion of degraded SpaA peptides. We then identified a thiol-disulfide oxidoreductase (MdbA), whose structure exhibits a conserved thioredoxin-like domain with a CPHC active site. Remarkably, deletion of mdbA results in a severe temperature-sensitive cell division phenotype. This mutant also fails to assemble pilus structures and is greatly defective in toxin production. Consistent with these defects, the ΔmdbA mutant is attenuated in a guinea pig model of diphtheritic toxemia. Given its diverse cellular functions in cell division, pilus assembly and toxin production, we propose that MdbA is a component of the general oxidative folding machine in C. diphtheriae. © 2015 John Wiley & Sons Ltd.

  16. Nuclear fuel assembly

    International Nuclear Information System (INIS)

    Anthony, A.J.

    1980-01-01

    A bimetallic spacer means is cooperatively associated with a nuclear fuel assembly and operative to resist the occurrence of in-reactor bowing of the nuclear fuel assembly. The bimetallic spacer means in one embodiment of the invention includes a space grid formed, at least principally, of zircaloy to the external surface of which are attached a plurality of stainless steel strips. In another embodiment the strips are attached to fuel pins. In each of the embodiments, the stainless steel strips during power production expand outwardly to a greater extent than do the members to which the stainless steel strips are attached, thereby forming stiff springs which abut against like bimetallic spacer means with which the other nuclear fuel assemblies are provided in a given nuclear reactor core to thus prevent the occurrence of in-reactor bowing of the nuclear fuel assemblies. (author)

  17. Dynamics of particle production by strong electric fields in non-Abelian plasmas

    International Nuclear Information System (INIS)

    Dawson, John F.; Mihaila, Bogdan; Cooper, Fred

    2010-01-01

    We develop methods for computing the dynamics of fermion pair production by strong color electric fields including backreaction using the semiclassical Boltzmann-Vlasov (B-V) equation. We implement the Schwinger pair production by inserting a source term in the B-V equation which includes Pauli-Blocking effects. We present numerical results for a model with SU(2) symmetries in (1+1) Cartesian dimensions.

  18. High rate monitoring CH4 production dynamics and their link with behavioral phases in cattle

    OpenAIRE

    Blaise, Yannick; Lebeau, Frédéric; Andriamandroso, Andriamasinoro; Beckers, Yves; Heinesch, Bernard; Bindelle, Jérôme

    2016-01-01

    Microbial fermentation in the rumen produces methane (CH4) which is a loss of energy for ruminants and also contributes to global warming. While the respiration chamber is the standard reference for CH4 emissions quantification, daily CH4 production dynamics can be measured only by steps of 30 min and measurements on pasture are impossible. The alternative method using SF6 as tracer gas can be applied for grazing animals but provides average CH4 production values over at least several hours, ...

  19. Comparison between remote sensing and a dynamic vegetation model for estimating terrestrial primary production of Africa.

    Science.gov (United States)

    Ardö, Jonas

    2015-12-01

    Africa is an important part of the global carbon cycle. It is also a continent facing potential problems due to increasing resource demand in combination with climate change-induced changes in resource supply. Quantifying the pools and fluxes constituting the terrestrial African carbon cycle is a challenge, because of uncertainties in meteorological driver data, lack of validation data, and potentially uncertain representation of important processes in major ecosystems. In this paper, terrestrial primary production estimates derived from remote sensing and a dynamic vegetation model are compared and quantified for major African land cover types. Continental gross primary production estimates derived from remote sensing were higher than corresponding estimates derived from a dynamic vegetation model. However, estimates of continental net primary production from remote sensing were lower than corresponding estimates from the dynamic vegetation model. Variation was found among land cover classes, and the largest differences in gross primary production were found in the evergreen broadleaf forest. Average carbon use efficiency (NPP/GPP) was 0.58 for the vegetation model and 0.46 for the remote sensing method. Validation versus in situ data of aboveground net primary production revealed significant positive relationships for both methods. A combination of the remote sensing method with the dynamic vegetation model did not strongly affect this relationship. Observed significant differences in estimated vegetation productivity may have several causes, including model design and temperature sensitivity. Differences in carbon use efficiency reflect underlying model assumptions. Integrating the realistic process representation of dynamic vegetation models with the high resolution observational strength of remote sensing may support realistic estimation of components of the carbon cycle and enhance resource monitoring, providing suitable validation data is available.

  20. Model non-equilibrium molecular dynamics simulations of heat transfer from a hot gold surface to an alkylthiolate self-assembled monolayer.

    Science.gov (United States)

    Zhang, Yue; Barnes, George L; Yan, Tianying; Hase, William L

    2010-05-07

    Model non-equilibrium molecular dynamics (MD) simulations are presented of heat transfer from a hot Au {111} substrate to an alkylthiolate self-assembled monolayer (H-SAM) to assist in obtaining an atomic-level understanding of experiments by Wang et al. (Z. Wang, J. A. Carter, A. Lagutchev, Y. K. Koh, N.-H. Seong, D. G. Cahill, and D. D. Dlott, Science, 2007, 317, 787). Different models are considered to determine how they affect the heat transfer dynamics. They include temperature equilibrated (TE) and temperature gradient (TG) thermostat models for the Au(s) surface, and soft and stiff S/Au(s) models for bonding of the S-atoms to the Au(s) surface. A detailed analysis of the non-equilibrium heat transfer at the heterogeneous interface is presented. There is a short time temperature gradient within the top layers of the Au(s) surface. The S-atoms heat rapidly, much faster than do the C-atoms in the alkylthiolate chains. A high thermal conductivity in the H-SAM, perpendicular to the interface, results in nearly identical temperatures for the CH(2) and CH(3) groups versus time. Thermal-induced disorder is analyzed for the Au(s) substrate, the S/Au(s) interface and the H-SAM. Before heat transfer occurs from the hot Au(s) substrate to the H-SAM, there is disorder at the S/Au(s) interface and within the alkylthiolate chains arising from heat-induced disorder near the surface of hot Au(s). The short-time rapid heating of the S-atoms enhances this disorder. The increasing disorder of H-SAM chains with time results from both disorder at the Au/S interface and heat transfer to the H-SAM chains.

  1. Self-assembly dynamics for the transition of a globular aggregate to a fibril network of lysozyme proteins via a coarse-grained Monte Carlo simulation

    Directory of Open Access Journals (Sweden)

    R. B. Pandey

    2015-09-01

    Full Text Available The self-organizing dynamics of lysozymes (an amyloid protein with 148 residues with different numbers of protein chains, Nc = 1,5,10, and 15 (concentration 0.004 – 0.063 is studied by a coarse-grained Monte Carlo simulation with knowledge-based residue-residue interactions. The dynamics of an isolated lysozyme (Nc = 1 is ultra-slow (quasi-static at low temperatures and becomes diffusive asymptotically on raising the temperature. In contrast, the presence of interacting proteins leads to concentration induced protein diffusion at low temperatures and concentration-tempering sub-diffusion at high temperatures. Variation of the radius of gyration of the protein with temperature shows a systematic transition from a globular structure (at low T to a random coil (high T conformation when the proteins are isolated. The crossover from globular to random coil becomes sharper upon increasing the protein concentration (i.e. with Nc = 5,10, with larger Rg at higher temperatures and concentration; Rg becomes smaller on adding more protein chains (e.g. Nc = 15 a non-monotonic response to protein concentration. Analysis of the structure factor (S(q provides an estimate of the effective dimension (D ≥ 3, globular conformation at low temperature, and D ∼ 1.7, random coil, at high temperatures of the isolated protein. With many interacting proteins, the morphology of the self-assembly varies with scale, i.e. at the low temperature (T = 0.015, D ∼ 2.9 on the scale comparable to the radius of gyration of the protein, and D ∼ 2.3 at the large scale over the entire sample. The global network of fibrils appears at high temperature (T = 0.021 with D ∼ 1.7 (i.e. a random coil morphology at large scale involving tenuous distribution of micro-globules (at small scales.

  2. Production of hyaline-like cartilage by bone marrow mesenchymal stem cells in a self-assembly model.

    Science.gov (United States)

    Elder, Steven H; Cooley, Avery J; Borazjani, Ali; Sowell, Brittany L; To, Harrison; Tran, Scott C

    2009-10-01

    A scaffoldless or self-assembly approach to cartilage tissue engineering has been used to produce hyaline cartilage from bone marrow-derived mesenchymal stem cells (bMSCs), but the mechanical properties of such engineered cartilage and the effects the transforming growth factor (TGF) isoform have not been fully explored. This study employs a cell culture insert model to produce tissue-engineered cartilage using bMSCs. Neonatal pig bMSCs were isolated by plastic adherence and expanded in monolayer before being seeded into porous transwell inserts and cultured for 4 or 8 weeks in defined chondrogenic media containing either TGF-beta1 or TGF-beta3. Following biomechanical evaluation in confined compression, colorimetric dimethyl methylene blue and Sircol dye-binding assays were used to analyze glycosaminoglycan (GAG) and collagen contents, respectively. Histological sections were stained with toluidine blue for proteoglycans and with picrosirius red to reveal collagen orientation, and immunostained for detection of collagen types I and II. Neocartilage increased in thickness, collagen, and GAG content between 4 and 8 weeks. Proteoglycan concentration increased with depth from the top surface. The tissue contained much more collagen type II than type I, and there was a consistent pattern of collagen alignment. TGF-beta1-treated and TGF-beta3-treated constructs were similar at 4 weeks, but 8-week TGF-beta1 constructs had a higher aggregate modulus and GAG content compared to TGF-beta3. These results demonstrate that bMSCs can generate functional hyaline-like cartilage through a self-assembling process.

  3. Dynamic structural change of the self-assembled lanthanum complex induced by lithium triflate for direct catalytic asymmetric aldol-Tishchenko reaction.

    Science.gov (United States)

    Horiuchi, Yoshihiro; Gnanadesikan, Vijay; Ohshima, Takashi; Masu, Hyuma; Katagiri, Kosuke; Sei, Yoshihisa; Yamaguchi, Kentaro; Shibasaki, Masakatsu

    2005-09-05

    The development of a direct catalytic asymmetric aldol-Tishchenko reaction and the nature of its catalyst are described. An aldol-Tishchenko reaction of various propiophenone derivatives with aromatic aldehydes was promoted by [LaLi3(binol)3] (LLB), and reactivity and enantioselectivity were dramatically enhanced by the addition of lithium trifluoromethanesulfonate (LiOTf). First, we observed a dynamic structural change of LLB by the addition of LiOTf using 13C NMR spectroscopy, electronspray ionization mass spectrometry (ESI-MS), and cold-spray ionization mass spectrometry (CSI-MS). X-ray crystallography revealed that the structure of the newly generated self-assembled complex was a binuclear [La2Li4(binaphthoxide)5] complex 6. A reverse structural change of complex 6 to LLB by the addition of one equivalent of Li2(binol) was also confirmed by ESI-MS and experimental results. The drastic concentration effects on the direct catalytic asymmetric aldol-Tishchenko reaction suggested that the addition of LiOTf to LLB generated an active oligomeric catalyst species.

  4. Beyond "on" or "with": Questioning Power Dynamics and Knowledge Production in "Child-Oriented" Research Methodology

    Science.gov (United States)

    Hunleth, Jean

    2011-01-01

    By taking a reflexive approach to research methodology, this article contributes to discussions on power dynamics and knowledge production in the social studies of children. The author describes and analyzes three research methods that she used with children--drawing, child-led tape-recording and focus group discussions. These methods were carried…

  5. Forest production dynamics along a wood density spectrum in eastern US forests

    Science.gov (United States)

    C.W. Woodall; M.B. Russell; B.F. Walters; A.W. D' Amato; K. Zhu; S.S. Saatchi

    2015-01-01

    Emerging plant economics spectrum theories were confirmed across temperate forest systems of the eastern US where the use of a forest stand's mean wood density elucidated forest volume and biomass production dynamics integrating aspects of climate, tree mortality/growth, and rates of site occupancy.

  6. Amenable crossed product Banach algebras associated with a class of C*-dynamical systems

    NARCIS (Netherlands)

    Jeu, de M.F.E.; Elharti, R.; Pinto, P.R.

    2017-01-01

    We prove that the crossed product Banach algebra ℓ1(G,A;α) that is associated with a C∗-dynamical system (A,G,α) is amenable if G is a discrete amenable group and A is a commutative or finite dimensional C∗-algebra. Perspectives for further developments are indicated.

  7. Iridium-Catalyzed Dynamic Kinetic Isomerization: Expedient Synthesis of Carbohydrates from Achmatowicz Rearrangement Products.

    Science.gov (United States)

    Wang, Hao-Yuan; Yang, Ka; Bennett, Scott R; Guo, Sheng-rong; Tang, Weiping

    2015-07-20

    A highly stereoselective dynamic kinetic isomerization of Achmatowicz rearrangement products was discovered. This new internal redox isomerization provided ready access to key intermediates for the enantio- and diastereoselective synthesis of a series of naturally occurring sugars. The nature of the de novo synthesis also enables the preparation of both enantiomers. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Optimization of PV-based energy production by dynamic PV-panel/inverter configuration

    DEFF Research Database (Denmark)

    Paasch, Kasper; Nymand, Morten; Haase, Frerk

    This paper investigates the possible increase in annual energy production of a PV system with more than one MPPT (maximum power point tracker) input channels under Nordic illumination conditions, in case a concept of dynamic switching of the PV panels is used at the inputs of the inverters....

  9. Analysing the Effects of a Pigs Production Quota within a Dynamic CGE Framework

    DEFF Research Database (Denmark)

    Adams, Philip D; Hansen, Lill Thanning; Jacobsen, Lars Bo

    2001-01-01

    In this paper we address the issue of timing and announcement within a dynamic applied general equilibrium model of the Danish economy. Specifically we analyse the introduction of a quota on the production of pigs. Two scenarios are analysed, namely the introduction of a once-off quota without any...

  10. Dynamic Relationship between Gross Domestic Product and Domestic Investment in Rwanda

    Science.gov (United States)

    Ocaya, Bruno; Ruranga, Charles; Kaberuka, William

    2012-01-01

    This study uses a VAR model to analyse the dynamic relationship between gross domestic product (GDP) and domestic investment (DI) in Rwanda for the period 1970 to 2011. Several selection lag criteria chose a maximum lag of one, and a bivariate VAR(1) model specification in levels was adopted. Unit root tests show that both GDP and DI series are…

  11. Simultaneous oxidation of aniline and tannic acid with peroxydisulfate: self-assembly of oxidation products from nanorods to microspheres

    Czech Academy of Sciences Publication Activity Database

    Janoševic, A.; Ciric-Marjanovic, G.; Šljukic Paunkovic, B.; Pašti, I.; Trifunovic, S.; Marjanovic, B.; Stejskal, Jaroslav

    2012-01-01

    Roč. 162, 9/10 (2012), s. 843-856 ISSN 0379-6779 R&D Projects: GA ČR GA202/09/1626 Institutional research plan: CEZ:AV0Z40500505 Institutional support: RVO:61389013 Keywords : copolymerization * anilin e * tannic acid Subject RIV: BK - Fluid Dynamics Impact factor: 2.109, year: 2012

  12. Evaluation of hydrogen production system coupling with HTTR using dynamic analysis code

    International Nuclear Information System (INIS)

    Sato, Hiroyuki; Ohashi, Hirofumi; Inaba, Yoshitomo; Nishihara, Tetsuo; Hayashi, Koji; Inagaki, Yoshiyuki

    2006-01-01

    The Japan Atomic Energy Agency (JAEA) was entrusted 'Development of Nuclear Heat Utilization Technology' by Ministry of Education, Culture, Sports, Science and Technology. In this development, the JAEA investigated the system integration technology to couple the hydrogen production system by steam reforming with the High Temperature Engineering Test Reactor (HTTR). Prior to the construction of the hydrogen production system coupling with the HTTR, a dynamic analysis code had to be developed to evaluate the system transient behaviour of the hydrogen production system because there are no examples of chemical facilities coupled with nuclear reactor in the world. This report describes the evaluation of the hydrogen production system coupling with HTTR using analysis code, N-HYPAC, which can estimate transient behaviour of the hydrogen production system by steam reforming. The results of this investigation provide that the influence of the thermal disturbance caused by the hydrogen production system on the HTTR can be estimated well. (author)

  13. Photoelectrocatalytic Glucose Oxidation to Promote Hydrogen Production over Periodically Ordered TiO2 Nanotube Arrays Assembled of Pd Quantum Dots

    International Nuclear Information System (INIS)

    Zhang, Yajun; Zhao, Guohua; Shi, Huijie; Zhang, Ya-nan; Huang, Wenna; Huang, Xiaofeng; Wu, Zhongyi

    2015-01-01

    Highlights: • Solar-driven PEC glucose oxidation to promote hydrogen production was presented. • The excellent PEC activity of Pd QDs@TNTAs was investigated. • The rate of hydrogen production from glucose was about 15 times than water. • A low-cost and efficient method in renewables-to-hydrogen conversion was put forward. - Abstract: The development of highly efficient and low-cost approaches for catalytic hydrogen production from renewable energy is of tremendous importance for a truly sustainable hydrogen-based energy carrier in future life. Herein, the probability of utilizing solar light to product hydrogen from biomass derivative, glucose, was systematically demonstrated by using the periodically ordered TiO 2 nanotube arrays (TNTAs) assembled of Palladium quantum dots (Pd QDs), i.e. Pd QDs@ TNTAs as photoanode. The results showed that remarkably increased photocurrent density was obtained in the glucose solution compared to the pure KOH electrolyte over as-prepared photoelectrode, which indicated that the glucose could be faster oxidized than water oxidation, and thus could promote the hydrogen production on Pt cathode. The yield of hydrogen production from glucose oxidation reached as high as 164.8 μmol cm −1 over Pd QDs@TNTAs photoanode and Pt cathode system (denoted as Pd QDs@TNTAs/Pt) under the solar light irradiation for 6 h, which was about 15 times higher than that from pure water splitting. The superior hydrogen production performance could be attributed to the less endergonic process of the glucose oxidation than water, as well as the efficient synergistic photoelectrocatalytic (PEC) glucose oxidation over Pd QDs@TNTAs photoanode which possesses excellent photoelectrochemical performance and structure characteristics. Moreover, a probable mechanism for the PEC hydrogen production from biomass derivatives oxidation was proposed and discussed

  14. Dynamics of nutrient utilization, heat production, and body composition in broiler breeder hens during egg production.

    Science.gov (United States)

    Caldas, Justina V; Hilton, Katie; Boonsinchai, Nirun; England, Judith A; Mauromoustakos, Andy; Coon, Craig N

    2018-04-24

    Changes in heat production (HP) and body composition (BC) in modern broiler breeders can provide means to understand nutrient utilization. Twelve Cobb 500 breeders were evaluated 10 times from 26 to 59 wk of age. The same wired caged breeders were moved to respiratory chambers connected to an indirect calorimetry to obtain oxygen consumption (VO2) and carbon dioxide production (VCO2), HP, and respiratory exchange ratio (RER). The same hens were evaluated for BC using a dual X-ray absorptiometry (DEXA). Data were analyzed during light (16 h) and dark (8 h) period using a mixed model to evaluate calorimetry parameters, a factorial design 2 × 10 for normalized calorimetry parameters, and Complete Randomized Design (CRD)-one way ANOVA for BC. Means were separated by Tukey-Honest Significant difference (HSD). HP increased with age (d) in 0.152 kcal/d, VO2 and VCO2 were 0.031 and 0.024 L/d per each increase in age (d), respectively. In the light period, hens consumed +17.4 L/d VO2 and produced +18.9 L/d VCO2 (P production. Lean body mass ranged from 642 to 783 g/kg during the whole study reaching the lowest at 37 and 50 wk and the highest at 26 to 33 wk (P production is reduced, and HP increased at 54 and 59 wk (P lean mass structure. Broiler breeders change nutrient fuel use during egg production. Indirect calorimetry and DEXA can be used to pursue further feed strategies to maximize egg production and maintain a healthy breeder.

  15. Assemble-to-order systems: a review

    NARCIS (Netherlands)

    Atan, Z.; Ahmadi, T.; Stegehuis, C.; de Kok, A.G.; Adan, I.J.B.F.

    2017-01-01

    In this paper, we review the recent literature on assemble-to-order systems. Each assemble-to-order system consists of multiple components and end-products. The components are assembled into the end-products after information on customer demand is received but the decision on what components to

  16. Magnetic nanoparticle assemblies

    CERN Document Server

    Trohidou, Kalliopi N

    2014-01-01

    Magnetic nanoparticles with diameters in the range of a few nanometers are today at the cutting edge of modern technology and innovation because of their use in numerous applications ranging from engineering to biomedicine. A great deal of scientific interest has been focused on the functionalization of magnetic nanoparticle assemblies. The understanding of interparticle interactions is necessary to clarify the physics of these assemblies and their use in the development of high-performance magnetic materials. This book reviews prominent research studies on the static and dynamic magnetic properties of nanoparticle assemblies, gathering together experimental and computational techniques in an effort to reveal their optimized magnetic properties for biomedical use and as ultra-high magnetic recording media.

  17. A Dynamic Bayesian Network Model for the Production and Inventory Control

    Science.gov (United States)

    Shin, Ji-Sun; Takazaki, Noriyuki; Lee, Tae-Hong; Kim, Jin-Il; Lee, Hee-Hyol

    In general, the production quantities and delivered goods are changed randomly and then the total stock is also changed randomly. This paper deals with the production and inventory control using the Dynamic Bayesian Network. Bayesian Network is a probabilistic model which represents the qualitative dependence between two or more random variables by the graph structure, and indicates the quantitative relations between individual variables by the conditional probability. The probabilistic distribution of the total stock is calculated through the propagation of the probability on the network. Moreover, an adjusting rule of the production quantities to maintain the probability of a lower limit and a ceiling of the total stock to certain values is shown.

  18. Liaison based assembly design

    Energy Technology Data Exchange (ETDEWEB)

    Ames, A.; Kholwadwala, D.; Wilson, R.H.

    1996-12-01

    Liaison Based Assembly Design extends the current information infrastructure to support design in terms of kinematic relationships between parts, or liaisons. These liaisons capture information regarding contact, degrees-of-freedom constraints and containment relationships between parts in an assembly. The project involved defining a useful collection of liaison representations, investigating their properties, and providing for maximum use of the data in downstream applications. We tested our ideas by implementing a prototype system involving extensions to Pro/Engineer and the Archimedes assembly planner. With an expanded product model, the design system is more able to capture design intent. When a product update is attempted, increased knowledge availability improves our ability to understand the effect of design changes. Manufacturing and analysis disciplines benefit from having liaison information available, so less time is wasted arguing over incomplete design specifications and our enterprise can be more completely integrated.

  19. Evaluation of Sustainability of Brazilian Ethanol Production: A model in System Dynamics

    Directory of Open Access Journals (Sweden)

    Arnoldo Jose de Hoyos Guevara

    2017-01-01

    Full Text Available System dynamics is an approach to analyze the behavior of complex systems, such as the productive chains, strictly considering the inherent characteristics. This approach is based on mathematical concepts of nonlinear processes developed in mathematics and physics and consolidated in engineering. The concepts inherent in this approach assists in creating a mathematical model that represents a production chain by using computer simulation. Thus, the main objective of this paper is to present the formalization of the dynamic model of assessing the sustainability of Brazilian ethanol production. We analyzed the external environment and the scenarios needed for a deeper understanding of relation of cause and effect, causal loops and diagrams of flows and stocks because of the awareness stage, with regard to understanding the problems involved, according to methodology known as design science.

  20. Design and production of a 2.5 kWe insulated metal substrate-based densely packed CPV assembly

    Science.gov (United States)

    Micheli, Leonardo; Sarmah, Nabin; Luo, Xichun; Reddy, K. S.; Mallick, Tapas K.

    2014-09-01

    The original design of a new 144-cell concentrating photovoltaic assembly is presented in this paper. It is conceived to work under 500 suns and to generate about 2.5 kWe. An insulated metal substrate was selected as baseplate, in order to get the best compromise between costs and thermal performances. It is based on a 2mm thick aluminum plate, which is in charge of removing the heat as quick as possible. The copper pattern and thickness has been designed accordingly to the IPC Generic Standard on Printed Board Design and to the restrictions of fit a reflective 125x primary optics and a 4x secondary refractive optics. The original outline of the conductive copper layer has been developed to minimize Joule losses by reducing the number of interconnections between the cells in series. Multijunction solar cells and Schottky bypass diodes have been soldered onto the board as surface mounted components. All the fabrication processes are described. This board represents a novelty for the innovative pattern of the conductive layer, which can be easily adapted to be coupled with different optics geometries and to allocate a different number of cells. The use of an IMS as baseplate will give an experimental contribution to the debate about the exploitability of this kind of substrates in CPV. This board is being characterized indoor and outdoor: the results will be used to improve the design and the reliability of the future receivers.

  1. Fuel assembly reconstitution

    International Nuclear Information System (INIS)

    Morgado, Mario M.; Oliveira, Monica G.N.; Ferreira Junior, Decio B.M.; Santos, Barbara O. dos; Santos, Jorge E. dos

    2009-01-01

    Fuel failures have been happened in Nuclear Power Plants worldwide, without lost of integrity and safety, mainly for the public, environment and power plants workers. The most common causes of these events are corrosion (CRUD), fretting and pellet cladding interaction. These failures are identified by increasing the activity of fission products, verified by chemical analyses of reactor coolant. Through these analyses, during the fourth operation cycle of Angra 2 Nuclear Power Plant, was possible to observe fuel failure indication. This indication was confirmed in the end of the cycle during the unloading of reactor core through leakage tests of fuel assembly, using the equipment called 'In Mast Sipping' and 'Box Sipping'. After confirmed, the fuel assembly reconstitution was scheduled, and happened in April, 2007, where was identified the cause and the fuel rod failure, which was substitute by dummy rods (zircaloy). The cause was fretting by 'debris'. The actions to avoid and prevent fuel assemblies failures are important. The goals of this work are to describe the methodology of fuel assembly reconstitution using the FARE (Fuel Assembly Reconstitution Equipment) system, to describe the results of this task in economic and security factors of the company and show how the fuel assembly failures are identified during operation and during the outage. (author)

  2. Synergistic dynamics of nitrogen and phosphorous influences lipid productivity in Chlorella minutissima for biodiesel production.

    Science.gov (United States)

    Arora, Neha; Patel, Alok; Pruthi, Parul A; Pruthi, Vikas

    2016-08-01

    The study synergistically optimized nitrogen and phosphorous concentrations for attainment of maximum lipid productivity in Chlorella minutissima. Nitrogen and phosphorous limited cells (N(L)P(L)) showed maximum lipid productivity (49.1±0.41mg/L/d), 1.47 folds higher than control. Nitrogen depletion resulted in reduced cell size with large sized lipid droplets encompassing most of the intracellular space while discrete lipid bodies were observed under nitrogen sufficiency. Synergistic N/P starvations showed more prominent effect on photosynthetic pigments as to individual deprivations. Phosphorous deficiency along with N starvation exhibited 17.12% decline in carbohydrate while no change in nitrogen sufficient cells were recorded. The optimum N(L)P(L) concentration showed balance between biomass and lipid by maintaining intermediate cell size, pigments, carbohydrate and proteins. FAME profile showed C14-C18 carbon chains in N(L)P(L) cells with biodiesel properties comparable to plant oil methyl esters. Hence, synergistic N/P limitation was effective for enhancing lipid productivity with reduced consumption of nutrients. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Fuel assembly

    International Nuclear Information System (INIS)

    Abe, Hideaki; Sakai, Takao; Ishida, Tomio; Yokota, Norikatsu.

    1992-01-01

    The lower ends of a plurality of plate-like shape memory alloys are secured at the periphery of the upper inside of the handling head of a fuel assembly. As the shape memory alloy, a Cu-Zn alloy, a Ti-Pd alloy or a Fe-Ni alloy is used. When high temperature coolants flow out to the handling head, the shape memory alloy deforms by warping to the outer side more greatly toward the upper portion thereof with the temperature increase of the coolants. As the result, the shape of the flow channel of the coolants is changed so as to enlarge at the exit of the upper end of the fuel assembly. Then, the pressure loss of the coolants in the fuel assembly is decreased by the enlargement. Accordingly, the flow rate of the coolants in the fuel assembly is increased to lower the temperature of the coolants. Further, high temperature coolants and low temperature coolants are mixed sufficiently just above the fuel assembly. This can suppress the temperature fluctuation of the mixed coolants in the upper portion of the reactor core, thereby enabling to decrease a fatigue and failures of the structural components in the upper portion of the reactor core. (I.N.)

  4. Industrial Assembly Cases

    DEFF Research Database (Denmark)

    Ellekilde, Lars-Peter; Buch, Jacob Pørksen; Iversen, Thorbjørn Mosekjær

    This technical report presents 13 different industrial assembly tasks, which are composed of 70 different operations. The report is written to provide an overview and do as such not contain product specific information such as object weights, dimensions etc. The operations are classified into a set...

  5. Biosynthesis: Reprogramming assembly lines

    Science.gov (United States)

    Menon, Binuraj R. K.; Jenner, Matthew

    2018-03-01

    Rational engineering of biosynthetic assembly lines for production of new compounds is an attractive prospect, yet it presents many challenges. Learning from biology, some of the rules for expanding the chemical diversity of non-ribosomal peptides have been uncovered in two recent studies.

  6. Decomposition and Cross-Product-Based Method for Computing the Dynamic Equation of Robots

    Directory of Open Access Journals (Sweden)

    Ching-Long Shih

    2012-08-01

    Full Text Available This paper aims to demonstrate a clear relationship between Lagrange equations and Newton-Euler equations regarding computational methods for robot dynamics, from which we derive a systematic method for using either symbolic or on-line numerical computations. Based on the decomposition approach and cross-product operation, a computing method for robot dynamics can be easily developed. The advantages of this computing framework are that: it can be used for both symbolic and on-line numeric computation purposes, and it can also be applied to biped systems, as well as some simple closed-chain robot systems.

  7. Dynamic flowgraph modeling of process and control systems of a nuclear-based hydrogen production plant

    Energy Technology Data Exchange (ETDEWEB)

    Al-Dabbagh, Ahmad W. [Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario (Canada); Lu, Lixuan [Faculty of Energy Systems and Nuclear Science, Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario (Canada)

    2010-09-15

    Modeling and analysis of system reliability facilitate the identification of areas of potential improvement. The Dynamic Flowgraph Methodology (DFM) is an emerging discrete modeling framework that allows for capturing time dependent behaviour, switching logic and multi-state representation of system components. The objective of this research is to demonstrate the process of dynamic flowgraph modeling of a nuclear-based hydrogen production plant with the copper-chlorine (Cu-Cl) cycle. Modeling of the thermochemical process of the Cu-Cl cycle in conjunction with a networked control system proposed for monitoring and control of the process is provided. This forms the basis for future component selection. (author)

  8. Sustainable MSD prevention: management for continuous improvement between prevention and production. Ergonomic intervention in two assembly line companies.

    Science.gov (United States)

    Caroly, S; Coutarel, F; Landry, A; Mary-Cheray, I

    2010-07-01

    To increase output and meet customers' needs, companies have turned to the development of production management systems: Kaizen, one piece flow, Kanban, etc. The aim of such systems is to accelerate decisions, react to environmental issues and manage various productions. In the main, this type of management system has led to the continuous improvement of production performance. Consequently, such production management systems can have unexpected negative effects on operators' health and safety. Conversely, regulation and control systems focusing on work-related risks have obliged firms to implement health and safety management systems such as OHSAS 18001. The purpose of this type of system, also based on continuous improvement, is to reduce risks, facilitate work-related activities and identify solutions in terms of equipment and tools. However, the prevention actions introduced through health and safety systems often result in other unexpected and unwanted effects on production. This paper shows how companies can improve the way they are run by taking into account both types of management system. Copyright 2010 Elsevier Ltd. All rights reserved.

  9. Benchmark calculations of power distribution within fuel assemblies. Phase 2: comparison of data reduction and power reconstruction methods in production codes

    International Nuclear Information System (INIS)

    2000-01-01

    Systems loaded with plutonium in the form of mixed-oxide (MOX) fuel show somewhat different neutronic characteristics compared with those using conventional uranium fuels. In order to maintain adequate safety standards, it is essential to accurately predict the characteristics of MOX-fuelled systems and to further validate both the nuclear data and the computation methods used. A computation benchmark on power distribution within fuel assemblies to compare different techniques used in production codes for fine flux prediction in systems partially loaded with MOX fuel was carried out at an international level. It addressed first the numerical schemes for pin power reconstruction, then investigated the global performance including cross-section data reduction methods. This report provides the detailed results of this second phase of the benchmark. The analysis of the results revealed that basic data still need to be improved, primarily for higher plutonium isotopes and minor actinides. (author)

  10. Human Assisted Assembly Processes

    Energy Technology Data Exchange (ETDEWEB)

    CALTON,TERRI L.; PETERS,RALPH R.

    2000-01-01

    Automatic assembly sequencing and visualization tools are valuable in determining the best assembly sequences, but without Human Factors and Figure Models (HFFMs) it is difficult to evaluate or visualize human interaction. In industry, accelerating technological advances and shorter market windows have forced companies to turn to an agile manufacturing paradigm. This trend has promoted computerized automation of product design and manufacturing processes, such as automated assembly planning. However, all automated assembly planning software tools assume that the individual components fly into their assembled configuration and generate what appear to be a perfectly valid operations, but in reality the operations cannot physically be carried out by a human. Similarly, human figure modeling algorithms may indicate that assembly operations are not feasible and consequently force design modifications; however, if they had the capability to quickly generate alternative assembly sequences, they might have identified a feasible solution. To solve this problem HFFMs must be integrated with automated assembly planning to allow engineers to verify that assembly operations are possible and to see ways to make the designs even better. Factories will very likely put humans and robots together in cooperative environments to meet the demands for customized products, for purposes including robotic and automated assembly. For robots to work harmoniously within an integrated environment with humans the robots must have cooperative operational skills. For example, in a human only environment, humans may tolerate collisions with one another if they did not cause much pain. This level of tolerance may or may not apply to robot-human environments. Humans expect that robots will be able to operate and navigate in their environments without collisions or interference. The ability to accomplish this is linked to the sensing capabilities available. Current work in the field of cooperative

  11. 75 FR 44283 - In the Matter of Certain Dynamic Random Access Memory Semiconductors and Products Containing Same...

    Science.gov (United States)

    2010-07-28

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-707] In the Matter of Certain Dynamic Random Access Memory Semiconductors and Products Containing Same, Including Memory Modules; Notice of a... importation of certain dynamic random access memory semiconductors and products containing same, including...

  12. Process development for automated solar cell and module production. Task 4. Automated array assembly. Quarterly report No. 1

    Energy Technology Data Exchange (ETDEWEB)

    Hagerty, J. J.

    1980-10-15

    Work has been divided into five phases. The first phase is to modify existing hardware and controlling computer software to: (1) improve cell-to-cell placement accuracy, (2) improve the solder joint while reducing the amount of solder and flux smear on the cell's surface, and (3) reduce the system cycle time to 10 seconds. The second phase involves expanding the existing system's capabilities to be able to reject broken cells and make post-solder electrical tests. Phase 3 involves developing new hardware to allow for the automated encapsulation of solar modules. This involves three discrete pieces of hardware: (1) a vacuum platen end effector for the robot which allows it to pick up the 1' x 4' array of 35 inter-connected cells. With this, it can also pick up the cover glass and completed module, (2) a lamination preparation station which cuts the various encapsulation components from roll storage and positions them for encapsulation, and (3) an automated encapsulation chamber which interfaces with the above two and applies the heat and vacuum to cure the encapsulants. Phase 4 involves the final assembly of the encapsulated array into a framed, edge-sealed module completed for installation. For this we are using MBA's Glass Reinforced Concrete (GRC) in panels such as those developed by MBA for JPL under contract No. 955281. The GRC panel plays the multiple role of edge frame, substrate and mounting structure. An automated method of applying the edge seal will also be developed. The final phase (5) is the fabrication of six 1' x 4' electrically active solar modules using the above developed equipment. Progress is reported. (WHK)

  13. Fuel assembly

    International Nuclear Information System (INIS)

    Nakatsuka, Masafumi; Matsuzuka, Ryuji.

    1976-01-01

    Object: To provide a fuel assembly which can decrease pressure loss of coolant to uniform temperature. Structure: A sectional area of a flow passage in the vicinity of an inner peripheral surface of a wrapper tube is limited over the entire length to prevent the temperature of a fuel element in the outermost peripheral portion from being excessively decreased to thereby flatten temperature distribution. To this end, a plurality of pincture-frame-like sheet metals constituting a spacer for supporting a fuel assembly, which has a plurality of fuel elements planted lengthwise and in given spaced relation within the wrapper tube, is disposed in longitudinal grooves and in stacked fashion to form a substantially honeycomb-like space in cross section. The fuel elements are inserted and supported in the space to form a fuel assembly. (Kamimura, M.)

  14. Fuel assemblies

    International Nuclear Information System (INIS)

    Nagano, Mamoru; Yoshioka, Ritsuo

    1983-01-01

    Purpose: To effectively utilize nuclear fuels by increasing the reactivity of a fuel assembly and reduce the concentration at the central region thereof upon completion of the burning. Constitution: A fuel assembly is bisected into a central region and a peripheral region by disposing an inner channel box within a channel box. The flow rate of coolants passing through the central region is made greater than that in the peripheral region. The concentration of uranium 235 of the fuel rods in the central region is made higher. In such a structure, since the moderating effect in the central region is improved, the reactivity of the fuel assembly is increased and the uranium concentration in the central region upon completion of the burning can be reduced, fuel economy and effective utilization of uranium can be attained. (Kamimura, M.)

  15. Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli.

    Science.gov (United States)

    Harder, Björn-Johannes; Bettenbrock, Katja; Klamt, Steffen

    2018-01-01

    Based on the recently constructed Escherichia coli itaconic acid production strain ita23, we aimed to improve the productivity by applying a two-stage process strategy with decoupled production of biomass and itaconic acid. We constructed a strain ita32 (MG1655 ΔaceA Δpta ΔpykF ΔpykA pCadCs), which, in contrast to ita23, has an active tricarboxylic acid (TCA) cycle and a fast growth rate of 0.52 hr -1 at 37°C, thus representing an ideal phenotype for the first stage, the growth phase. Subsequently we implemented a synthetic genetic control allowing the downregulation of the TCA cycle and thus the switch from growth to itaconic acid production in the second stage. The promoter of the isocitrate dehydrogenase was replaced by the Lambda promoter (p R ) and its expression was controlled by the temperature-sensitive repressor CI857 which is active at lower temperatures (30°C). With glucose as substrate, the respective strain ita36A grew with a fast growth rate at 37°C and switched to production of itaconic acid at 28°C. To study the impact of the process strategy on productivity, we performed one-stage and two-stage bioreactor cultivations. The two-stage process enabled fast formation of biomass resulting in improved peak productivity of 0.86 g/L/hr (+48%) and volumetric productivity of 0.39 g/L/hr (+22%) in comparison to the one-stage process. With our dynamic production strain, we also resolved the glutamate auxotrophy of ita23 and increased the itaconic acid titer to 47 g/L. The temperature-dependent activation of gene expression by the Lambda promoters (p R /p L ) has been frequently used to improve protein or, in a few cases, metabolite production in two-stage processes. Here we demonstrate that the system can be as well used in the opposite direction to selectively knock-down an essential gene (icd) in E. coli to design a two-stage process for improved volumetric productivity. The control by temperature avoids expensive inducers and has the

  16. Application of dynamic compaction technology for high performance and precision powder products

    International Nuclear Information System (INIS)

    Lee, Chang Kyu; Lee, Jung Gu; Lee, Min Ku; Uhm, Young Rang; Park, Jin Ju; Lee, Gyeong Ja; Hong, Soon Jik

    2011-06-01

    The automation technology of magnetic pulsed compaction (MPC) has been developed for mass production of high performance powder products by dynamic compaction method. The pulse power equipment in MPC system has been modified for improved lifetime and productivity, so the modified one can produce high-density compacts at a rate of 10 times/min with semipermanent lifetime. Using this modified pulse power equipment, two types of automated MPC apparatus were constructed, which are operated by mechanical and hydraulic driving systems, respectively. By repeated compaction operations at a rate of 5 times/min, durability and productivity of these automated apparatus have been proven to be suitable for mass production. In addition, the lifetime of mold and punch for MPC has been improved by optimizing design and material as well as employing new lubrication system. By applying such automated MPC apparatus, detailed mass production technologies have been developed for several powder products such as diamond drilling segments, ceramic targets for optical coating, silver coins for water disinfection and small powder products for automobile. The developed powder products showed improved performance as compared to commercial ones, so they will be mass-produced industrially before long

  17. Assessing the productivity change of water companies in England and Wales: A dynamic metafrontier approach.

    Science.gov (United States)

    Molinos-Senante, María; Maziotis, Alexandros; Sala-Garrido, Ramon

    2017-07-15

    The assessment of productivity change and its drivers across water companies and over time is a powerful tool for both regulators and companies when setting water tariffs. Water and sewerage companies (WaSCs) and water only companies (WoCs) provide different services. Hence, their productivity change cannot directly be evaluated jointly. In this paper and for the first time, we provide a pioneering approach to assess and compare the dynamics of productivity change of WaSCs and WoCs. To achieve this, both the traditional Malmquist productivity index and the metafrontier Malmquist productivity index and its components are computed to assess the productivity change for a sample of English and Welsh water companies over the period 2001-2014. The findings from both indices indicate that productivity for both WaSCs and WoCs did not improve during this period, mainly due to the negative shift in the production frontier which offset the positive effect of efficiency change. It is also reported that the performance of the WoCs over time was slightly better than that of the WaSCs. Finally, our study provides some insights into the relationship between productivity change and the regulatory cycle. This information is essential to improve the regulation of water and sewerage services, contributing to the long-term sustainability of the urban water cycle. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Assemblies of amyloid-β30-36 hexamer and its G33V/L34T mutants by replica-exchange molecular dynamics simulation.

    Directory of Open Access Journals (Sweden)

    Zhenyu Qian

    Full Text Available The aggregation of amyloid-β peptides is associated with the pathogenesis of Alzheimer's disease, in which the 30-36 fragments play an important part as a fiber-forming hydrophobic region. The fibrillar structure of Aβ30-36 has been detected by means of X-ray diffraction, but its oligomeric structural determination, biophysical characterization, and pathological mechanism remain elusive. In this study, we have investigated the structures of Aβ30-36 hexamer as well as its G33V and L34T mutants in explicit water environment using replica-exchange molecular dynamics (REMD simulations. Our results show that the wild-type (WT Aβ30-36 hexamer has a preference to form β-barrel and bilayer β-sheet conformations, while the G33V or L34T mutation disrupts the β-barrel structures: the G33V mutant is homogenized to adopt β-sheet-rich bilayers, and the structures of L34T mutant on the contrary get more diverse. The hydrophobic interaction plays a critical role in the formation and stability of oligomeric assemblies among all the three systems. In addition, the substitution of G33 by V reduces the β-sheet content in the most populated conformations of Aβ30-36 oligomers through a steric effect. The L34T mutation disturbs the interpeptide hydrogen bonding network, and results in the increased coil content and morphological diversity. Our REMD runs provide structural details of WT and G33V/L34T mutant Aβ30-36 oligomers, and molecular insight into the aggregation mechanism, which will be helpful for designing novel inhibitors or amyloid-based materials.

  19. N.3142 National Assembly law proposition aiming to help the purchasing of households facing the petroleum products prices increase

    International Nuclear Information System (INIS)

    2006-01-01

    This text presents the problem of the households purchasing facing the increase of the petroleum products. It recalls the government policy, and criticizes the french government gap in favor of the households. In the second part it proposes to replace the ''floating TIPP'' and to reallocate a part of the exceptional incomes of the petroleum companies. (A.L.B.)

  20. Evaluation of water productivity under climate change in irrigated areas of the arid Northwest China using an assemble statistical downscaling method and an agro-hydrological model

    Science.gov (United States)

    Liu, Liu; Guo, Zezhong; Huang, Guanhua

    2018-06-01

    The Heihe River Basin (HRB) is the second largest inland river basin, located in the arid region of Northwest China with a serious water shortage. Evaluation of water productivity will provide scientific implications for agricultural water-saving in irrigated areas of the arid region under climate change. Based on observed meteorological data, 23 GCMs outputs and the ERA-40 reanalysis data, an assemble statistical downscaling model was developed to generate climate change scenarios under RCP2.6, RCP4.5, RCP8.5 respectively, which were then used to drive the SWAP-EPIC model to simulate crop growth in the irrigated areas of the middle HRB for the future period from 2018 to 2047. Crop yield showed an increasing trend, while crop water consumption decreased gradually in Gaotai and Ganzhou irrigated areas. The water productivity in future 30 years showed an increasing trend in both Gaotai and Ganzhou areas, with the most significant increase under RCP4.5 scenario, which were both larger than 2 kg m-3. Compared with that of the period from 2012 to 2015, the water productivity during 2018-2047 under three RCP scenarios increased by 9.2, 14.3 and 11.8 % in the Gaotai area, and 15.4, 21.6, 19.9 % in the Ganzhou area, respectively.

  1. Entropy production and nonequilibrium stationarity in quantum dynamical systems. Physical meaning of van Hove limit

    International Nuclear Information System (INIS)

    Ojima, Izumi

    1989-01-01

    With aid of the so-called dilation method, a concise formula is obtained for the entropy production in the algebraic formulation of quantum dynamical systems. In this framework, the initial ergodic state of an external force system plays a pivotal role in generating dissipativity as a conditional expectation. The physical meaning of van Hove limit is clarified through the scale-changing transformation to control transitions between microscopic and macroscopic levels. It plays a crucial role in realizing the macroscopic stationary in the presence of microscopic fluctuations as well as in the transition from non-Markovian (groupoid) dynamics to Markovian dissipative processes of state changes. The extension of the formalism to cases with spatial and internal inhomogeneity is indicated in the light of the groupoid dynamical systems and noncommutative integration theory

  2. Dynamics of Mycoplasma hyopneumoniae seroconversion and infection in pigs in the three main production systems.

    Science.gov (United States)

    Giacomini, Enrico; Ferrari, Nicola; Pitozzi, Alessandra; Remistani, Michela; Giardiello, Daniele; Maes, Dominiek; Alborali, Giovanni Loris

    2016-06-01

    In this study, we investigated the dynamics of Mycoplasma hyopneumoniae infections in 66 pig farms, with different production systems (one-, two-, and three-site systems), and considered different risk factors. Serological assay was used to detect serum antibodies against M. hyopneumoniae and real time polymerase chain reaction (RT-PCR) was performed to detect M. hyopneumoniae DNA in tracheobronchial swabs. Results demonstrated that M. hyopneumoniae infection status was predominantly influenced by the age of the animals and the type of production system. Infection rates were higher in older animals and the prevalence was higher in the one- and two-site systems than in the three-site systems. Dynamics of infection by RT-PCR showed that earlier M. hyopneumoniae infection on one-site farms occurs earlier, while on two- and three-site farms occurs later but spreads faster, suggesting that contact between animals of different age favors the transmission.

  3. A dynamic programming algorithm for the buffer allocation problem in homogeneous asymptotically reliable serial production lines

    Directory of Open Access Journals (Sweden)

    Diamantidis A. C.

    2004-01-01

    Full Text Available In this study, the buffer allocation problem (BAP in homogeneous, asymptotically reliable serial production lines is considered. A known aggregation method, given by Lim, Meerkov, and Top (1990, for the performance evaluation (i.e., estimation of throughput of this type of production lines when the buffer allocation is known, is used as an evaluative method in conjunction with a newly developed dynamic programming (DP algorithm for the BAP. The proposed algorithm is applied to production lines where the number of machines is varying from four up to a hundred machines. The proposed algorithm is fast because it reduces the volume of computations by rejecting allocations that do not lead to maximization of the line's throughput. Numerical results are also given for large production lines.

  4. N2O production dynamics in nitrifying/denitrifying activated sludge under defined environmental conditions

    DEFF Research Database (Denmark)

    Pellicer i Nàcher, Carles; Jensen, Marlene Mark; Petersen, Morten S.

    contributor to global warming and the destruction of the ozone layer. The present study makes use of unique datasets collected during controlled batch tests with activated sludge biomass to test and calibrate a pseudo-mechanistic model that predicts N2O production by nitrifying and heterotrophic bacteria....... The proposed model described successfully the observed N2O production dynamics and confirmed that the availability of ammonia, low dissolved oxygen and nitrite accumulation were the main factors triggering N2O production. Nitrifier-denitrification was proposed as the main pathway catalyzing the conversion...... that a minor portion of the N2O produced was actually released to the gas phase. This work represents a step further in the use and calibration of process models to control and understand better N2O production and emissions during conventional wastewater treatment....

  5. Valve assembly

    International Nuclear Information System (INIS)

    Sandling, M.

    1981-01-01

    An improved valve assembly, used for controlling the flow of radioactive slurry, is described. Radioactive contamination of the air during removal or replacement of the valve is prevented by sucking air from the atmosphere through a portion of the structure above the valve housing. (U.K.)

  6. Fuel assembly

    International Nuclear Information System (INIS)

    Gjertsen, R.K.; Bassler, E.A.; Huckestein, E.A.; Salton, R.B.; Tower, S.N.

    1988-01-01

    A fuel assembly adapted for use with a pressurized water nuclear reactor having capabilities for fluid moderator spectral shift control is described comprising: parallel arranged elongated nuclear fuel elements; means for providing for axial support of the fuel elements and for arranging the fuel elements in a spaced array; thimbles interspersed among the fuel elements adapted for insertion of a rod control cluster therewithin; means for structurally joining the fuel elements and the guide thimbles; fluid moderator control means for providing a volume of low neutron absorbing fluid within the fuel assembly and for removing a substantially equivalent volume of reactor coolant water therefrom, a first flow manifold at one end of the fuel assembly sealingly connected to a first end of the moderator control tubes whereby the first ends are commonly flow connected; and a second flow manifold, having an inlet passage and an outlet passage therein, sealingly connected to a second end of the moderator control tubes at a second end of the fuel assembly

  7. Productivity Dynamics and the Role of “Big-Box” Entrants in Retailing

    OpenAIRE

    Maican, Florin; Orth, Matilda

    2012-01-01

    Entry of large (“big-box”) stores along with a drastic fall in the total number of stores is a striking trend in retail markets. We use a dynamic structural model to estimate retail productivity in a local market setting. In particular, we provide a general strategy of how to measure the causal effect of entry of large stores on productivity separate from demand. To control for endogeneity of large entrants, we use political preferences. Using detailed data on all retail food stores in Sweden...

  8. Forming of the dynamics of the changes in convergent production system depending on size of production party

    Directory of Open Access Journals (Sweden)

    Bożena Zwolińska

    2017-09-01

    Full Text Available Background: In terms of Lean Six Sigma, the whole process focuses on clients and their needs. Existence of a client generates the supply of companies. Extended customization has a negative impact for a structure of the production system. Dynamics of changes and no predictability of system’s state in time t+1 lead to increase of the operational costs. It particularly affects those companies which are producing goods using MTO (make – to – order method in short series. The goal of this article is to establish a mathematical model defining how the structure of a production system is subject to change depending on the volume of the production batch for a production system in accordance with MTO. Furthermore pilot calculations have been presented which determine the probability value, how subsequent random variables are contained within three standard deviations (±3δ from the determined expected value (ET for the entire production structure. Months of analysis and research on introducing selected lean toolbox components to a polish company from the small and medium enterprises sector resulted in the models presented in the article. The production structure of the discussed actual facility is complex and is of converged nature in accordance with MTO, while the final products are manufactured in short production series with a relatively wide customization options. Materials and results: Wrought models consider theories of  Klir and Maserovicz [Mesarovic 1964] and also theory of mass operation (one of the probability areas.  In the article there are results from two models which are fundamental in defining problems in logistics engineering and production in scientific research. Important attribute of presented models is a fact that they consider relations between variables in a structure of consecutive processes and also consider relations between a size of production party and a real object. Presented models are not only theoretical coverage

  9. EEG Spectral Dynamics of Video Commercials: Impact of the Narrative on the Branding Product Preference.

    Science.gov (United States)

    Wang, Regina W Y; Chang, Yu-Ching; Chuang, Shang-Wen

    2016-11-07

    Neuromarketing has become popular and received a lot of attention. The quality of video commercials and the product information they convey to consumers is a hotly debated topic among advertising agencies and product advertisers. This study explored the impact of advertising narrative and the frequency of branding product exposures on the preference for the commercial and the branding product. We performed electroencephalography (EEG) experiments on 30 subjects while they watched video commercials. The behavioral data indicated that commercials with a structured narrative and containing multiple exposures of the branding products had a positive impact on the preference for the commercial and the branding product. The EEG spectral dynamics showed that the narratives of video commercials resulted in higher theta power of the left frontal, bilateral occipital region, and higher gamma power of the limbic system. The narratives also induced significant cognitive integration-related beta and gamma power of the bilateral temporal regions and the parietal region. It is worth noting that the video commercials with a single exposure of the branding products would be indicators of attention. These new findings suggest that the presence of a narrative structure in video commercials has a critical impact on the preference for branding products.

  10. EEG Spectral Dynamics of Video Commercials: Impact of the Narrative on the Branding Product Preference

    Science.gov (United States)

    Wang, Regina W. Y.; Chang, Yu-Ching; Chuang, Shang-Wen

    2016-01-01

    Neuromarketing has become popular and received a lot of attention. The quality of video commercials and the product information they convey to consumers is a hotly debated topic among advertising agencies and product advertisers. This study explored the impact of advertising narrative and the frequency of branding product exposures on the preference for the commercial and the branding product. We performed electroencephalography (EEG) experiments on 30 subjects while they watched video commercials. The behavioral data indicated that commercials with a structured narrative and containing multiple exposures of the branding products had a positive impact on the preference for the commercial and the branding product. The EEG spectral dynamics showed that the narratives of video commercials resulted in higher theta power of the left frontal, bilateral occipital region, and higher gamma power of the limbic system. The narratives also induced significant cognitive integration-related beta and gamma power of the bilateral temporal regions and the parietal region. It is worth noting that the video commercials with a single exposure of the branding products would be indicators of attention. These new findings suggest that the presence of a narrative structure in video commercials has a critical impact on the preference for branding products. PMID:27819348

  11. On extremals of the entropy production by ‘Langevin–Kramers’ dynamics

    International Nuclear Information System (INIS)

    Muratore-Ginanneschi, Paolo

    2014-01-01

    We refer as ‘Langevin–Kramers’ dynamics to a class of stochastic differential systems exhibiting a degenerate ‘metriplectic’ structure. This means that the drift field can be decomposed into a symplectic and a gradient-like component with respect to a pseudo-metric tensor associated with random fluctuations affecting increments of only a sub-set of the degrees of freedom. Systems in this class are often encountered in applications as elementary models of Hamiltonian dynamics in a heat bath eventually relaxing to a Boltzmann steady state. Entropy production control in Langevin–Kramers models differs from the now well-understood case of Langevin–Smoluchowski dynamics for two reasons. First, the definition of entropy production stemming from fluctuation theorems specifies a cost functional which does not act coercively on all degrees of freedom of control protocols. Second, the presence of a symplectic structure imposes a non-local constraint on the class of admissible controls. Using Pontryagin control theory and restricting the attention to additive noise, we show that smooth protocols attaining extremal values of the entropy production appear generically in continuous parametric families as a consequence of a trade-off between smoothness of the admissible protocols and non-coercivity of the cost functional. Uniqueness is, however, always recovered in the over-damped limit as extremal equations reduce at leading order to the Monge–Ampère–Kantorovich optimal mass-transport equations. (paper)

  12. A model of milk production in lactating dairy cows in relation to energy and nitrogen dynamics.

    Science.gov (United States)

    Johnson, I R; France, J; Cullen, B R

    2016-02-01

    A generic daily time-step model of a dairy cow, designed to be included in whole-system pasture simulation models, is described that includes growth, milk production, and lactation in relation to energy and nitrogen dynamics. It is a development of a previously described animal growth and metabolism model that describes animal body composition in terms of protein, water, and fat, and energy dynamics in relation to growth requirements, resynthesis of degraded protein, and animal activity. This is further developed to include lactation and fetal growth. Intake is calculated in relation to stage of lactation, pasture availability, supplementary feed, and feed quality. Energy costs associated with urine N excretion and methane fermentation are accounted for. Milk production and fetal growth are then calculated in relation to the overall energy and nitrogen dynamics. The general behavior of the model is consistent with expected characteristics. Simulations using the model as part of a whole-system pasture simulation model (DairyMod) are compared with experimental data where good agreement between pasture, concentrate and forage intake, as well as milk production over 3 consecutive lactation cycles, is observed. The model is shown to be well suited for inclusion in large-scale system simulation models. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  13. Soft matter assemblies as nanomedicine platforms for cancer chemotherapy: a journey from market products towards novel approaches.

    Science.gov (United States)

    Jäger, Eliézer; Giacomelli, Fernando C

    2015-01-01

    The current review aims to outline the likely medical applications of nanotechnology and the potential of the emerging field of nanomedicine. Nanomedicine can be defined as the investigation area encompassing the design of diagnostics and therapeutics at the nanoscale, including nanobots, nanobiosensors, nanoparticles and other nanodevices, for the remediation, prevention and diagnosis of a variety of illnesses. The ultimate goal of nanomedicine is to improve patient quality-of-life. Because nanomedicine includes the rational design of an enormous number of nanotechnology-based products focused on miscellaneous diseases, a variety of nanomaterials can be employed. Therefore, this review will focus on recent advances in the manufacture of soft matterbased nanomedicines specifically designed to improve diagnostics and cancer chemotherapy efficacy. It will be particularly highlighted liposomes, polymer-drug conjugates, drug-loaded block copolymer micelles and biodegradable polymeric nanoparticles, emphasizing the current investigations and potential novel approaches towards overcoming the remaining challenges in the field as well as formulations that are in clinical trials and marketed products.

  14. Forest based biomass for energy in Uganda: Stakeholder dynamics in feedstock production

    International Nuclear Information System (INIS)

    Hazelton, Jennifer A.; Windhorst, Kai; Amezaga, Jaime M.

    2013-01-01

    Insufficient energy supply and low levels of development are closely linked. Both are major issues in Uganda where growing demand cannot be met by overstretched infrastructure and the majority still rely on traditional biomass use. Uganda's renewable energy policy focuses on decentralised sources including modern biomass. In this paper, stakeholder dynamics and potential socio-economic impacts of eight modern bioenergy feedstock production models in Uganda are considered, and key considerations for future planning provided. For these models the main distinctions were land ownership (communal or private) and feedstock type (by-product or plantation). Key social issues varied by value chain (corporate, government or farmer/NGO), and what production arrangement was in place (produced for own use or sale). Small, privately owned production models can be profitable but are unlikely to benefit landless poor and, if repeated without strategic planning, could result in resource depletion. Larger projects can have greater financial benefits, though may have longer term natural resource impacts felt by adjacent communities. Bioenergy initiatives which allow the rural poor to participate through having a collaborative stake, rather than receiving information, and provide opportunities for the landless are most likely to result in socio-economic rural development to meet policy goals. The structured approach to understanding stakeholder dynamics used was found to be robust and sufficiently adaptable to provide meaningful analysis. In conclusion; local, context-specific planning and assessment for bioenergy projects, where all stakeholders have the opportunity to be collaborators in the process throughout its full lifecycle, is required to achieve rural development objectives. -- Highlights: • Stakeholder dynamics and socio-economics in 8 Ugandan bioenergy projects considered. • Key distinctions were ownership, feedstock, value chain and production arrangement. • Small

  15. Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae.

    Science.gov (United States)

    Mol, Clifford D; Brooun, Alexei; Dougan, Douglas R; Hilgers, Mark T; Tari, Leslie W; Wijnands, Robert A; Knuth, Mark W; McRee, Duncan E; Swanson, Ronald V

    2003-07-01

    UDP-N-acetylmuramic acid:L-alanine ligase (MurC) catalyzes the addition of the first amino acid to the cytoplasmic precursor of the bacterial cell wall peptidoglycan. The crystal structures of Haemophilus influenzae MurC in complex with its substrate UDP-N-acetylmuramic acid (UNAM) and Mg(2+) and of a fully assembled MurC complex with its product UDP-N-acetylmuramoyl-L-alanine (UMA), the nonhydrolyzable ATP analogue AMPPNP, and Mn(2+) have been determined to 1.85- and 1.7-A resolution, respectively. These structures reveal a conserved, three-domain architecture with the binding sites for UNAM and ATP formed at the domain interfaces: the N-terminal domain binds the UDP portion of UNAM, and the central and C-terminal domains form the ATP-binding site, while the C-terminal domain also positions the alanine. An active enzyme structure is thus assembled at the common domain interfaces when all three substrates are bound. The MurC active site clearly shows that the gamma-phosphate of AMPPNP is positioned between two bound metal ions, one of which also binds the reactive UNAM carboxylate, and that the alanine is oriented by interactions with the positively charged side chains of two MurC arginine residues and the negatively charged alanine carboxyl group. These results indicate that significant diversity exists in binding of the UDP moiety of the substrate by MurC and the subsequent ligases in the bacterial cell wall biosynthesis pathway and that alterations in the domain packing and tertiary structure allow the Mur ligases to bind sequentially larger UNAM peptide substrates.

  16. Exopolymeric substances from drinking water biofilms: Dynamics of production and relation with disinfection by products.

    Science.gov (United States)

    Lemus Pérez, M F; Rodríguez Susa, M

    2017-06-01

    Exopolymeric substances (EPS) as an external matrix of biofilm could react with disinfectants in drinking water networks forming disinfection by-products (DBP). Based on an experimental setup using two chlorine conditions-biofilm 1 (2.6 ± 0.8 mgCl/L) and biofilm 2 (0.7 ± 0.2 mg Cl/L)-samples of biofilms were recovered during 9 campaigns and EPS were extracted. Analyses of SUVA, fluorescence and amino acid (AA) content were carried out on the EPS to observe variation over time and correlations with DBP formation potential (DBP fp ) after chlorination. SUVA values were under 2 L/mgC*m showing that both EPS were hydrophilic. Slightly higher SUVA in biofilm 2 with low variation over time was observed. Fluorescence showed that aromatic proteins and fulvic like substances were the principal components and increased in biofilm 1 over time. AA decreased with time, and higher values of alanine, threonine, proline and isoleucine were observed in biofilm 2. Based on general associations, the SUVA of biofilm 2 correlated well with chloroform (CF) (r = 0.80). Generally, in both biofilms, tryptophan-like substances were negatively correlated with DBP while humic acid-like substances correlated positively, but with low indexes (r = 0.3-0.6). Correlations of data from individual sampling increased the indices (r over 0.8), suggesting a temporal influence of other factors on DBP fp such as inorganics, filtered water and the structural composition of EPS. In biofilm 1, Br-haloacetic acids (Br-HAA), dibromoacetonitrile and bromochloro acetonitrile were inversely associated with arginine and valine, as were di and trichloropropanone to arginine. On the contrary, in biofilm 2, the following amino acids correlated positively with DBP: alanine with Br-HAA, alanine with CF, alanine with N-DBP (chloropicrin, di and tri-chloro acetonitrile), and valine with CF. As this is the first report about the relation between temporal variation of EPS and DBP fp of biofilms in two

  17. Developing a Dynamic SPARROW Water Quality Decision Support System Using NASA Remotely-Sensed Products

    Science.gov (United States)

    Al-Hamdan, M. Z.; Smith, R. A.; Hoos, A.; Schwarz, G. E.; Alexander, R. B.; Crosson, W. L.; Srikishen, J.; Estes, M., Jr.; Cruise, J.; Al-Hamdan, A.; Ellenburg, W. L., II; Flores, A.; Sanford, W. E.; Zell, W.; Reitz, M.; Miller, M. P.; Journey, C. A.; Befus, K. M.; Swann, R.; Herder, T.; Sherwood, E.; Leverone, J.; Shelton, M.; Smith, E. T.; Anastasiou, C. J.; Seachrist, J.; Hughes, A.; Graves, D.

    2017-12-01

    The USGS Spatially Referenced Regression on Watershed Attributes (SPARROW) surface water quality modeling system has been widely used for long term, steady state water quality analysis. However, users have increasingly requested a dynamic version of SPARROW that can provide seasonal estimates of nutrients and suspended sediment to receiving waters. The goal of this NASA-funded project is to develop a dynamic decision support system to enhance the southeast SPARROW water quality model and finer-scale dynamic models for selected coastal watersheds through the use of remotely-sensed data and other NASA Land Information System (LIS) products. The spatial and temporal scale of satellite remote sensing products and LIS modeling data make these sources ideal for the purposes of development and operation of the dynamic SPARROW model. Remote sensing products including MODIS vegetation indices, SMAP surface soil moisture, and OMI atmospheric chemistry along with LIS-derived evapotranspiration (ET) and soil temperature and moisture products will be included in model development and operation. MODIS data will also be used to map annual land cover/land use in the study areas and in conjunction with Landsat and Sentinel to identify disturbed areas that might be sources of sediment and increased phosphorus loading through exposure of the bare soil. These data and others constitute the independent variables in a regression analysis whose dependent variables are the water quality constituents total nitrogen, total phosphorus, and suspended sediment. Remotely-sensed variables such as vegetation indices and ET can be proxies for nutrient uptake by vegetation; MODIS Leaf Area Index can indicate sources of phosphorus from vegetation; soil moisture and temperature are known to control rates of denitrification; and bare soil areas serve as sources of enhanced nutrient and sediment production. The enhanced SPARROW dynamic models will provide improved tools for end users to manage water

  18. Dynamic simulation of pure hydrogen production via ethanol steam reforming in a catalytic membrane reactor

    International Nuclear Information System (INIS)

    Hedayati, Ali; Le Corre, Olivier; Lacarrière, Bruno; Llorca, Jordi

    2016-01-01

    Ethanol steam reforming (ESR) was performed over Pd-Rh/CeO 2 catalyst in a catalytic membrane reactor (CMR) as a reformer unit for production of fuel cell grade pure hydrogen. Experiments were performed at 923 K, 6–10 bar, and fuel flow rates of 50–200 μl/min using a mixture of ethanol and distilled water with steam to carbon ratio of 3. A static model for the catalytic zone was derived from the Arrhenius law to calculate the total molar production rates of ESR products, i.e. CO, CO 2 , CH 4 , H 2 , and H 2 O in the catalytic zone of the CMR (coefficient of determination R 2  = 0.993). The pure hydrogen production rate at steady state conditions was modeled by means of a static model based on the Sieverts' law. Finally, a dynamic model was developed under ideal gas law assumptions to simulate the dynamics of pure hydrogen production rate in the case of the fuel flow rate or the operating pressure set point adjustment (transient state) at isothermal conditions. The simulation of fuel flow rate change dynamics was more essential compared to the pressure change one, as the system responded much faster to such an adjustment. The results of the dynamic simulation fitted very well to the experimental values at P = 7–10 bar, which proved the robustness of the simulation based on the Sieverts' law. The simulation presented in this work is similar to the hydrogen flow rate adjustments needed to set the electrical load of a fuel cell, when fed online by the pure hydrogen generating reformer studied. - Highlights: • Ethanol steam reforming (ESR) experiments were performed in a Pd-Ag membrane reactor. • The model of the catalytic zone of the reactor was derived from the Arrhenius law. • The permeation zone (membrane) was modeled based on the Sieverts' law. • The Sieverts' law model showed good results for the range of P = 7–10 bar. • Pressure and fuel flow rate adjustments were considered for dynamic simulation.

  19. Mapping quantitative trait loci (QTL in sheep. II. Meta-assembly and identification of novel QTL for milk production traits in sheep

    Directory of Open Access Journals (Sweden)

    Lam Mary K

    2009-10-01

    Full Text Available Abstract An (Awassi × Merino × Merino backcross family of 172 ewes was used to map quantitative trait loci (QTL for different milk production traits on a framework map of 200 loci across all autosomes. From five previously proposed mathematical models describing lactation curves, the Wood model was considered the most appropriate due to its simplicity and its ability to determine ovine lactation curve characteristics. Derived milk traits for milk, fat, protein and lactose yield, as well as percentage composition and somatic cell score were used for single and two-QTL approaches using maximum likelihood estimation and regression analysis. A total of 15 significant (P P http://crcidp.vetsci.usyd.edu.au/cgi-bin/gbrowse/oaries_genome/. Many of the QTL for milk production traits have been reported on chromosomes 1, 3, 6, 16 and 20. Those on chromosomes 3 and 20 are in strong agreement with the results reported here. In addition, novel QTL were found on chromosomes 7, 8, 9, 14, 22 and 24. In a cross-species comparison, we extended the meta-assembly by comparing QTL regions of sheep and cattle, which provided strong evidence for synteny conservation of QTL regions for milk, fat, protein and somatic cell score data between cattle and sheep.

  20. Application of a system dynamics model to improve the performance of make-to-order production

    Directory of Open Access Journals (Sweden)

    Yi-Lun Elaine Ho

    2015-08-01

    Full Text Available This study provides a system dynamics (SD model of make-to-order (MTO production and discusses the key factors of production improvement. The proposed system can be divided into three subsystems: income/cost, order/production, and human resources (HR. The time delay between customer demand, production demand, order quantity, material demand, and inventory is considered in a practical application. In addition, this paper considers how the cycle time is affected by the total input of HR; how unit transportation cost is influenced by the delivery quantity; and how unit penalty (shortage cost is affected by the amount of shortage. The production capacity, yield, and holding cost needed to satisfy practical demands are all considered. A simulation approach to MTO production for meeting contract requests is presented in this study. Simulation results reveal that the amount of shortage will be the most important factor affecting the policy for the replenishment of material. Although the rise in production capacity leads to a reduced amount of shortage, it does not play a significant role. A sensitivity analysis of the replenishment of material policy is conducted to find out the best suggested policy. The SD model is also shown to quickly simulate changes in system behaviour, which allows an organisation enough time to respond to and conquer any unpredictable situation that might occur.

  1. Production and quality assurance automation in the Goddard Space Flight Center Flight Dynamics Facility

    Science.gov (United States)

    Chapman, K. B.; Cox, C. M.; Thomas, C. W.; Cuevas, O. O.; Beckman, R. M.

    1994-01-01

    The Flight Dynamics Facility (FDF) at the NASA Goddard Space Flight Center (GSFC) generates numerous products for NASA-supported spacecraft, including the Tracking and Data Relay Satellites (TDRS's), the Hubble Space Telescope (HST), the Extreme Ultraviolet Explorer (EUVE), and the space shuttle. These products include orbit determination data, acquisition data, event scheduling data, and attitude data. In most cases, product generation involves repetitive execution of many programs. The increasing number of missions supported by the FDF has necessitated the use of automated systems to schedule, execute, and quality assure these products. This automation allows the delivery of accurate products in a timely and cost-efficient manner. To be effective, these systems must automate as many repetitive operations as possible and must be flexible enough to meet changing support requirements. The FDF Orbit Determination Task (ODT) has implemented several systems that automate product generation and quality assurance (QA). These systems include the Orbit Production Automation System (OPAS), the New Enhanced Operations Log (NEOLOG), and the Quality Assurance Automation Software (QA Tool). Implementation of these systems has resulted in a significant reduction in required manpower, elimination of shift work and most weekend support, and improved support quality, while incurring minimal development cost. This paper will present an overview of the concepts used and experiences gained from the implementation of these automation systems.

  2. Structure and dynamics of the microbial communities underlying the carboxylate platform for biofuel production

    Energy Technology Data Exchange (ETDEWEB)

    Hollister, Emily B.; Gentry, Terry J. [Texas A and M Univ., College Station, TX (United States). Dept. of Soil and Crop Sciences; Forrest, Andrea K.; Holtzapple, Mark T. [Texas A and M Univ., College Station, TX (United States). Dept. of Chemical Engineering; Wilkinson, Heather H.; Ebbole, Daniel J. [Texas A and M Univ., College Station, TX (United States). Dept. of Plant Pathology and Microbiology; Malfatti, Stephanie A.; Tringe, Susannah G. [DOE Joint Genome Institute, Walnut Creek, CA (United States)

    2010-09-15

    The carboxylate platform utilizes a mixed microbial community to convert lignocellulosic biomass into chemicals and fuels. While much of the platform is well understood, little is known about its microbiology. Mesophilic (40 C) and thermophilic (55 C) fermentations employing a sorghum feedstock and marine sediment inoculum were profiled using 16S rRNA tag-pyrosequencing over the course of a 30-day incubation. The contrasting fermentation temperatures converted similar amounts of biomass, but the mesophilic community was significantly more productive, and the two temperatures differed significantly with respect to propionic and butyric acid production. Pyrotag sequencing revealed the presence of dynamic communities that responded rapidly to temperature and changed substantially over time. Both temperatures were dominated by bacteria resembling Clostridia, but they shared few taxa in common. The species-rich mesophilic community harbored a variety of Bacteroidetes, Actinobacteria, and {gamma}-Proteobacteria, whereas the thermophilic community was composed mainly of Clostridia and Bacilli. Despite differences in composition and productivity, similar patterns of functional class dynamics were observed. Over time, organisms resembling known cellulose degraders decreased in abundance, while organisms resembling known xylose degraders increased. Improved understanding of the carboxylate platform's microbiology will help refine platform performance and contribute to our growing knowledge regarding biomass conversion and biofuel production processes. (orig.)

  3. A heuristic algorithm to approximate dynamic program of a novel new product development process

    Directory of Open Access Journals (Sweden)

    Hamed Fazlollahtabar

    2016-01-01

    Full Text Available We are concerned with a new product development (NPD network in digital environment in which the aim is to find integrated attributes for value added purposes. Different views exist for new product development. Here, the effective factors are categorized into customers, competitors and the company’s own past experience. Also, various attributes are considered for the development of a product. Thus, using digital data of attributes, the optimal set of attributes is chosen for user in the new product development. Regarding the multi stage decision making process of the customer, competitor and company’s own past experience, we develop a multi-dimensional dynamic program as a useful tool for multi stage decision making. To counteract the dynamism of the digital data in different time periods, two concepts of state and policy direction are introduced to determine the cost of moving through the stages of the proposed NPD digital network. Since the space requirements and value function computations become impractical for even moderate size, we approximate the optimal value function developing a heuristic algorithm.

  4. Structure and dynamics of the microbial communities underlying the carboxylate platform for biofuel production

    Energy Technology Data Exchange (ETDEWEB)

    Hollister, Emily B; Gentry, Terry J [Texas A and M Univ., College Station, TX (United States). Dept. of Soil and Crop Sciences; Forrest, Andrea K; Holtzapple, Mark T [Texas A and M Univ., College Station, TX (United States). Dept. of Chemical Engineering; Wilkinson, Heather H; Ebbole, Daniel J [Texas A and M Univ., College Station, TX (United States). Dept. of Plant Pathology and Microbiology; Malfatti, Stephanie A; Tringe, Susannah G [DOE Joint Genome Institute, Walnut Creek, CA (United States)

    2010-09-15

    The carboxylate platform utilizes a mixed microbial community to convert lignocellulosic biomass into chemicals and fuels. While much of the platform is well understood, little is known about its microbiology. Mesophilic (40 C) and thermophilic (55 C) fermentations employing a sorghum feedstock and marine sediment inoculum were profiled using 16S rRNA tag-pyrosequencing over the course of a 30-day incubation. The contrasting fermentation temperatures converted similar amounts of biomass, but the mesophilic community was significantly more productive, and the two temperatures differed significantly with respect to propionic and butyric acid production. Pyrotag sequencing revealed the presence of dynamic communities that responded rapidly to temperature and changed substantially over time. Both temperatures were dominated by bacteria resembling Clostridia, but they shared few taxa in common. The species-rich mesophilic community harbored a variety of Bacteroidetes, Actinobacteria, and {gamma}-Proteobacteria, whereas the thermophilic community was composed mainly of Clostridia and Bacilli. Despite differences in composition and productivity, similar patterns of functional class dynamics were observed. Over time, organisms resembling known cellulose degraders decreased in abundance, while organisms resembling known xylose degraders increased. Improved understanding of the carboxylate platform's microbiology will help refine platform performance and contribute to our growing knowledge regarding biomass conversion and biofuel production processes. (orig.)

  5. Production of Truncated Candida antarctica Lipase B Gene Using Automated PCR Gene Assembly Protocol and Expression in Yeast for use in Ethanol and Biodiesel Production.

    Science.gov (United States)

    An improved column-based process for production of biodiesel was developed using a column containing a strongly basic anion-exchange resin in sequence with a column containing a resin to which a lipase biocatalyst is bound. Currently most biodiesel is produced by transesterification of triglyceride...

  6. Fuel assembly

    International Nuclear Information System (INIS)

    Yokota, Tokunobu.

    1990-01-01

    A fuel assembly used in a FBR type nuclear reactor comprises a plurality of fuel rods and a moderator guide member (water rod). A moderator exit opening/closing mechanism is formed at the upper portion of the moderator guide member for opening and closing a moderator exit. In the initial fuel charging operation cycle to the reactor, the moderator exit is closed by the moderator exit opening/closing mechanism. Then, voids are accumulated at the inner upper portion of the moderator guide member to harden spectrum and a great amount of plutonium is generated and accumulated in the fuel assembly. Further, in the fuel re-charging operation cycle, the moderator guide member is used having the moderator exit opened. In this case, voids are discharged from the moderator guide member to decrease the ratio, and the plutonium accumulated in the initial charging operation cycle is burnt. In this way, the fuel economy can be improved. (I.N.)

  7. Fuel assemblies

    International Nuclear Information System (INIS)

    Echigoya, Hironori; Nomata, Terumitsu.

    1983-01-01

    Purpose: To render the axial distribution relatively flat. Constitution: First nuclear element comprises a fuel can made of zircalloy i.e., the metal with less neutron absorption, which is filled with a plurality of UO 2 pellets and sealed by using a lower end plug, a plenum spring and an upper end plug by means of welding. Second fuel element is formed by substituting a part of the UO 2 pellets with a water tube which is sealed with water and has a space for allowing the heat expansion. The nuclear fuel assembly is constituted by using the first and second fuel elements together. In such a structure, since water reflects neutrons and decrease their leakage to increase the temperature, reactivity is added at the upper portion of the fuel assembly to thereby flatten the axial power distribution. Accordingly, stable operation is possible only by means of deep control rods while requiring no shallow control rods. (Sekiya, K.)

  8. Fuel assembly

    International Nuclear Information System (INIS)

    Watanabe, Shoichi; Hirano, Yasushi.

    1998-01-01

    A one-half or more of entire fuel rods in a fuel assembly comprises MOX fuel rods containing less than 1wt% of burnable poisons, and at least a portion of the burnable poisons comprises gadolinium. Then, surplus reactivity at an initial stage of operation cycle is controlled to eliminate burnable poisons remained unburnt at a final stage, as well as increase thermal reactivity. In addition, the content of fission plutonium is determined to greater than the content of uranium 235, and fuel rods at corner portions are made not to incorporate burnable poisons. Fuel rods not containing burnable poisons are disposed at positions in adjacent with fuel rods facing to a water rod at one or two directions. Local power at radial center of the fuel assembly is increased to flatten the distortion of radial power distribution. (N.H.)

  9. Approach of describing dynamic production of volatile fatty acids from sludge alkaline fermentation.

    Science.gov (United States)

    Wang, Dongbo; Liu, Yiwen; Ngo, Huu Hao; Zhang, Chang; Yang, Qi; Peng, Lai; He, Dandan; Zeng, Guangming; Li, Xiaoming; Ni, Bing-Jie

    2017-08-01

    In this work, a mathematical model was developed to describe the dynamics of fermentation products in sludge alkaline fermentation systems for the first time. In this model, the impacts of alkaline fermentation on sludge disintegration, hydrolysis, acidogenesis, acetogenesis, and methanogenesis processes are specifically considered for describing the high-level formation of fermentation products. The model proposed successfully reproduced the experimental data obtained from five independent sludge alkaline fermentation studies. The modeling results showed that alkaline fermentation largely facilitated the disintegration, acidogenesis, and acetogenesis processes and severely inhibited methanogenesis process. With the pH increase from 7.0 to 10.0, the disintegration, acidogenesis, and acetogenesis processes respectively increased by 53%, 1030%, and 30% while methane production decreased by 3800%. However, no substantial effect on hydrolysis process was found. The model also indicated that the pathway of acetoclastic methanogenesis was more severely inhibited by alkaline condition than that of hydrogentrophic methanogenesis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. A Solvable Dynamic Principal-Agent Model with Linear Marginal Productivity

    Directory of Open Access Journals (Sweden)

    Bing Liu

    2018-01-01

    Full Text Available We study how to design an optimal contract which provides incentives for agent to put forth the desired effort in a continuous time dynamic moral hazard model with linear marginal productivity. Using exponential utility and linear production, three different information structures, full information, hidden actions and hidden savings, are considered in the principal-agent model. Applying the stochastic maximum principle, we solve the model explicitly, where the agent’s optimization problem becomes the principal’s problem of choosing an optimal contract. The explicit solutions to our model allow us to analyze the distortion of allocations. The main effect of hidden actions is a reduction of effort, but the a smaller effect is on the consumption allocation. In the hidden saving case, the consumption distortion almost vanishes but the effort distortion is expanded. In our setting, the agent’s optimal effort is also reduced with the decline of marginal productivity.

  11. Implementation of unused production factors in agriculture by means of dynamic optimization models with random constraints

    Directory of Open Access Journals (Sweden)

    Jadwiga Zaród

    2011-01-01

    Full Text Available The farms of Western Pomerania province possess a large surplus of manpower. The dynamic optimization models with random constraints served the investigation of the possibilities of implementation of the unused man-hours. Those models regarded four successive years 2003-2006. The solution proceeded in two steps. The first step let us construct the assumption of the surplus or the deficiency of production factors. In the next step additional variables regarding the lease of arable grounds were introduced while the unused man-hours were implemented with various probability. The optimal solutions indicated the area of particular crops, the quantity of livestock and the farm income dependent on the use of the existing employment. This study aims at the presentation of the possibility of implementation of unused man-hours in farms dealing solely with the crop production and also the production of crop and livestock.

  12. Technology Evaluation of Process Configurations for Second Generation Bioethanol Production using Dynamic Model-based Simulations

    DEFF Research Database (Denmark)

    Morales Rodriguez, Ricardo; Meyer, Anne S.; Gernaey, Krist

    2011-01-01

    An assessment of a number of different process flowsheets for bioethanol production was performed using dynamic model-based simulations. The evaluation employed diverse operational scenarios such as, fed-batch, continuous and continuous with recycle configurations. Each configuration was evaluated...... against the following benchmark criteria, yield (kg ethanol/kg dry-biomass), final product concentration and number of unit operations required in the different process configurations. The results has shown the process configuration for simultaneous saccharification and co-fermentation (SSCF) operating...... in continuous mode with a recycle of the SSCF reactor effluent, results in the best productivity of bioethanol among the proposed process configurations, with a yield of 0.18 kg ethanol /kg dry-biomass....

  13. General Assembly

    CERN Multimedia

    Staff Association

    2016-01-01

    5th April, 2016 – Ordinary General Assembly of the Staff Association! In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Tuesday, April 5th 2016 from 11:00 to 12:00 in BE Auditorium, Meyrin (6-2-024). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its financial management, and an opportunity to express one’s opinion, including taking part in the votes. Other points are listed on the agenda, as proposed by the Staff Council. Who can vote? Only “ordinary” members (MPE) of the SA can vote. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give his/her opinion? The Ordinary General Asse...

  14. Fuel assembly

    International Nuclear Information System (INIS)

    Ueda, Sei; Ando, Ryohei; Mitsutake, Toru.

    1995-01-01

    The present invention concerns a fuel assembly suitable to a BWR-type reactor and improved especially with the nuclear characteristic, heat performance, hydraulic performance, dismantling or assembling performance and economical property. A part of poison rods are formed as a large-diameter/multi-region poison rods having a larger diameter than a fuel rod. A large number of fuel rods are disposed surrounding a large diameter water rod and a group of the large-diameter/multi-region poison rods in adjacent with the water rod. The large-diameter water rod has a burnable poison at the tube wall portion. At least a portion of the large-diameter poison rods has a coolant circulation portion allowing coolants to circulate therethrough. Since the large-diameter poison rods are disposed at a position of high neutron fluxes, a large neutron multiplication factor suppression effect can be provided, thereby enabling to reduce the number of burnable poison rods relative to fuels. As a result, power peaking in the fuel assembly is moderated and a greater amount of plutonium can be loaded. In addition the flow of cooling water which tends to gather around the large diameter water rod can be controlled to improve cooling performance of fuels. (N.H.)

  15. Production of membrane-electrode assemblies to be used in high temperature solid oxide fuel cells; Producao de conjugados eletrolito-eletrodos para pilhas a combustivel de oxido solido de alta temperatura

    Energy Technology Data Exchange (ETDEWEB)

    Villalobos, Pedro R.; Silva, Gilmar Clemente; Miranda, Paulo Emilio V. de [Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Metalurgica e de Materiais. Lab. de Hidrogenio], e-mail: vlobos@labh2.coppe.ufrj.br

    2004-07-01

    This article describes the production and characterization of membrane-electrode assemblies to be used in high temperature solid oxide fuel cells. The single cells produced were characterized using scanning electron microscopy and X ray diffractometry, seeking the morphological characterization of the complete device and to verify the stability of the materials used with respect to the processing conditions. (author)

  16. Photocatalytic H{sub 2} production from water splitting under visible light irradiation using Eosin Y-sensitized mesoporous-assembled Pt/TiO{sub 2} nanocrystal photocatalyst

    Energy Technology Data Exchange (ETDEWEB)

    Sreethawong, Thammanoon; Chavadej, Sumaeth [The Petroleum and Petrochemical College, Chulalongkorn University, Soi Chula 12, Phyathai Road, Pathumwan, Bangkok 10330 (Thailand); Center for Petroleum, Petrochemicals, and Advanced Materials, Chulalongkorn University, Bangkok 10330 (Thailand); Junbua, Chompoonuch [The Petroleum and Petrochemical College, Chulalongkorn University, Soi Chula 12, Phyathai Road, Pathumwan, Bangkok 10330 (Thailand)

    2009-05-15

    Sensitized photocatalytic production of hydrogen from water splitting is investigated under visible light irradiation over mesoporous-assembled titanium dioxide (TiO{sub 2}) nanocrystal photocatalysts, without and with Pt loading. The photocatalysts are synthesized by a sol-gel process with the aid of a structure-directing surfactant and are characterized by N{sub 2} adsorption-desorption analysis, X-ray diffraction, UV-vis spectroscopy, scanning electron microscopy, transmission electron microscopy and energy-dispersive X-ray analysis. The dependence of hydrogen production on the type of TiO{sub 2} photocatalyst (synthesized mesoporous-assembled and commercial non-mesoporous-assembled TiO{sub 2} without and with Pt loading), the calcination temperature of the synthesized photocatalyst, the sensitizer (Eosin Y) concentration, the electron donor (diethanolamine) concentration, the photocatalyst dosage and the initial solution pH is systematically studied. The results show that in the presence of the Eosin Y sensitizer, the Pt-loaded mesoporous-assembled TiO{sub 2} synthesized by a single-step sol-gel process and calcined at 500 C exhibits the highest photocatalytic activity for hydrogen production from a 30 vol.% diethanolamine aqueous solution with dissolved 2 mM Eosin Y. Moreover, the optimum photocatalyst dosage and initial solution pH for the maximum photocatalytic activity for hydrogen production are 3.33 g dm{sup -3} and 11.5, respectively. (author)

  17. Fabrication of TiO{sub 2} hierarchical architecture assembled by nanowires with anatase/TiO{sub 2}(B) phase-junctions for efficient photocatalytic hydrogen production

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, Yong; Ouyang, Feng, E-mail: ouyangfh@hit.edu.cn

    2017-05-01

    Highlights: • H-titanate nanowires hierarchical architectures (TNH) were prepared by a hydrothermal method. • Calcinations of TNH leads to the formation of anatase/TiO{sub 2}(B) phase-junctions. • The hierarchical architecture offered enhanced light harvesting and large specific surface area. • The 1D nanowires and anatase/TiO{sub 2}(B) phase-junctions both can enhance the separation of photoinduced electron-hole. • The products calcined at the optimum conditions (450 °C) exhibited a maximum hydrogenproduction rate of 7808 μmol g{sup −1} h{sup −1}. - Abstract: TiO{sub 2} hierarchical architecture assembled by nanowires with anatase/TiO{sub 2}(B) phase-junctions was prepared by a hydrothermal process followed by calcinations. The optimum calcination treatment (450 °C) not only led to the formation of anatase/TiO{sub 2}(B) phase-junctions, but also kept the morphology of 1D nanowire and hierarchical architecture well. The T-450 load 0.5 wt% Pt cocatalysts showed the best photocatalytic hydrogen production activity, with a maximum hydrogen production rate of 7808 μmol g{sup −1} h{sup −1}. The high photocatalytic activity is ascribed to the combined effects of the following three factors: (1) the hierarchical architecture exhibits better light harvesting; (2) the larger specific surface area provides more surface active sites for the photocatalytic reaction; (3) the 1D nanowires and anatase/TiO{sub 2}(B) phase-junctions both can enhance the separation of photoinduced electron-hole pairs and inhibit their recombination.

  18. Future active layer dynamics and carbon dioxide production from thawing permafrost layers in Northeast Greenland

    DEFF Research Database (Denmark)

    Hollesen, Jørgen; Elberling, Bo; Jansson, P.E.

    2011-01-01

    Thawing permafrost and the resulting mineralization of previously frozen organic carbon (C) is considered an important future feedback from terrestrial ecosystems to the atmosphere. Here, we use a dynamic process oriented permafrost model, the CoupModel, to link surface and subsurface temperatures....... The model is successfully adjusted and applied for the study area and shown to be able to simulate active layer dynamics. Subsequently, the model is used to predict the active layer thickness under future warming scenarios. The model predicts an increase of maximum active layer thickness from today 70 to 80......–105 cm as a result of a 2–6 °C warming. An additional increase in the maximum active layer thickness of a few centimetres may be expected due to heat production from decomposition of organic matter. Simulated future soil temperatures and water contents are subsequently used with measured basal soil...

  19. Determining the number of kanbans for dynamic production systems: An integrated methodology

    Directory of Open Access Journals (Sweden)

    Özlem Uzun Araz

    2016-08-01

    Full Text Available Just-in-time (JIT is a management philosophy that reduces the inventory levels and eliminates manufacturing wastes by producing only the right quantity at the right time. A kanban system is one of the key elements of JIT philosophy. Kanbans are used to authorize production and to control movement of materials in JIT systems. In Kanban systems, the efficiency of the manufacturing system depends on several factors such as number of kanbans, container size etc. Hence, determining the number of kanbans is a critical decision in Kanban systems. The aim of this study is to develop a methodology that can be used in order to determine the number of kanbans in a dynamic production environment. In this methodology, the changes in system state is monitored in real time manner, and the number of the kanbans are dynamically re-arranged. The proposed methodology integrates simulation, neural networks and Mamdani type fuzzy inference system. The methodology is modelled in simulation environment and applied on a hypothetic production system. We also performed several comparisons for different control policies to show the effectiveness of the proposed methodology.

  20. Collision dynamics and particle production in relativistic nucleus- nucleus collisions at CERN

    International Nuclear Information System (INIS)

    Harris, J.W.

    1990-03-01

    The possibility of forming a quark-gluon plasma is the primary motivation for studying nucleus-nucleus collisions at very high energies. Various ''signatures'' for the existence of a quark-gluon plasma in these collisions have been proposed. These include an enhancement in the production of strange particles, suppression of J/Ψ production, observation of direct photons from the plasma, event-by-event fluctuations in the rapidity distributions of produced particles, and various other observables. However, the system will evolve dynamically from a pure plasma or mixed phase through expansion, cooling, hadronization and freezeout into the final state particles. Therefore, to be able to determine that a new, transient state of matter has been formed it will be necessary to understand the space-time evolution of the collision process and the microscopic structure of hadronic interactions, at the level of quarks and gluons, at high temperatures and densities. In this talk I will review briefly the present state of our understanding of the dynamics of these collisions and, in addition, present a few recent results on particle production from the NA35 experiment at CERN. 21 refs., 5 figs

  1. Nectar production dynamics and sugar composition in two Mucuna species (Leguminosae, Faboideae) with different specialized pollinators

    Science.gov (United States)

    Agostini, Kayna; Sazima, Marlies; Galetto, Leonardo

    2011-11-01

    Nectar is secreted in particular rhythms throughout the lifespan of a flower, which allows determining the nectar production dynamics. This paper compares nectar features in Mucuna japira and Mucuna urens describing: dynamics of nectar production, floral response to nectar removal, resorption, nectar sugar composition, and variation in nectar sugar composition. M. japira inflorescence bears 12-21 yellow flowers, which are in anthesis for 7 days, whereas M. urens inflorescence bears 36-54 greenish flowers, but only 1-3 flowers are in anthesis simultaneously that last one night. Nectar volume and sugar concentration were measured, and the amount of sugar was estimated. Qualitative and quantitative nectar sugar composition was determined. Both species had a constant nectar sugar concentration (ca. 10% for M. japira and ca. 16% for M. urens) and secreted high volumes of nectar (ca. 340 μl per flower for M. japira and 310 μl per flower for M. urens), during 5 days for M. japira and 6 h for M. urens, but after the first removal, i.e., when flower opening mechanism is triggered, nectar production stops immediately. Nectar resorption occurred in both species. Nectar sugar composition showed some similarities between the species. Variation in nectar sugar composition occurred in both species. The Mucuna species are dependent on their pollinators to produce fruits and seeds, and they have different strategies to promote the necessary interaction with birds or bats, especially related to nectar and flower characteristics.

  2. New route for uranium concentrate production from Caetite ore, Bahia State, Brazil; dynamic leaching - direct precipitation

    Energy Technology Data Exchange (ETDEWEB)

    Morais, Carlos A. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)]. E-mail: cmorais@cdtn.br; Gomiero, Luiz A.; Scassiotti Filho, Walter [Industrias Nucleares do Brasil S.A. (INB), Caetite, BA (Brazil)]. E-mails: gomiero@inb.gov.br; scassiotti@inb.gov.br

    2007-07-01

    The common uranium concentrate production consists of ore leaching, uranium purification/concentration by solvent extraction and uranium precipitation as ammonium diuranate steps. In the present work, a new route of uranium concentrate production from Caetite, BA-Brazil ore was investigated. The following steps were investigated: dynamic leaching of the ground ore with sulfuric acid; sulfuric liquor pre-neutralization until pH 3.7; uranium peroxide precipitation. The study was carried out in bath and continuous circuits. In the dynamic leaching of ground ore in agitated tanks the uranium content in the leached ore may be as low as 100 {mu}g/g U{sub 3}O{sub 8}, depending on grinding size. In the pre-neutralization step, the iron content in the liquor is decreased in 99 wt.%, dropping from 3.62 g/L to 0.030 g/L. The sulfate content in the liquor reduces from 46 g/L to 22 g/L. A calcinated final product assaying 99.7 wt.% U{sub 3}O{sub 8} was obtained. The full process recovery was over 94%. (author)

  3. Dynamics of productivity change in the Australian electricity industry: Assessing the impacts of electricity reform

    Energy Technology Data Exchange (ETDEWEB)

    Aghdam, Reza Fathollahzadeh, E-mail: reza_f_a@yahoo.com [Department of Finance and Economics, College of Industrial Management, King Fahd University of Petroleum and Minerals, PO Box 257, Dhahran 31261 (Saudi Arabia)

    2011-06-15

    The Australian electricity industry has undergone a significant reform, since the mid-1990s. Key changes comprised functional unbundling, market restructuring, regulatory reform, public corporatisation and privatisation. Technological development has been another indisputable constituent of these changes, in the wake of ICT revolution. The principle rationale behind these changes has been that they would improve productivity of the industry and social well-being of people. This paper examines the dynamics of productivity changes in the Australian electricity industry and conducts several hypotheses-testings to identify whether industry's efficiency measures are truly improved as a result of the reform-driven changes. Malmquist Total Factor Productivity Index approach and ANOVA are used for this purpose. The results reveal that the productivity gains in the industry have been largely driven by technological improvements and, to a lesser extent, by reform-induced comparative efficiency gains. On average at national level and for the entire industry, there are efficiency gains that, to large extents, can be attributed to functional unbundling and public corporatisation and, to a lesser extent, to market restructuring and privatisation. The results, however, reveal that the reform-driven changes have made insignificant contribution to comparative efficiency, at the level of thermal generation. - Highlights: > Dynamics of productivity changes in Australian electricity industry are examined. > Several hypotheses are also tested against reform-driven changes. > Technology impact is proved to be far larger than reform-induced impacts. > Unbundling and corporatisation had larger impacts than market restructuring and privatisation. > At thermal generation level, no reform-induced impact is encountered.

  4. Floodplain Vegetation Productivity and Carbon Cycle Dynamics of the Middle Fork Flathead River of Northwest Montana

    Science.gov (United States)

    Oakins, A. J.; Kimball, J. S.; Relyea, S.; Stanford, J. A.

    2005-05-01

    River floodplains are vital natural features that store floodwaters, improve water quality, provide habitat, and create recreational opportunities. Recent studies have shown that strong interactions among flooding, channel and sediment movement, vegetation, and groundwater create a dynamic shifting habitat mosaic that promotes biodiversity and complex food webs. Multiple physical and environmental processes interact within these systems to influence forest productivity, including water availability, nutrient supply, soil texture, and disturbance history. This study is designed to quantify the role of groundwater depth and meteorology in determining spatial and temporal patterns of net primary productivity (NPP) within the Nyack floodplain of the Middle Fork Flathead River, Northwestern Montana. We examine three intensive field sites composed of mature, mixed deciduous and evergreen conifer forest with varying hydrologic and vegetative characteristics. We use a modified Biome-BGC ecosystem process model with field-collected data (LAI, increment growth cores, groundwater depth, vegetation sap-flow, and local meteorology) to describe the effects of floodplain groundwater dynamics on vegetation community structure, and carbon/nitrogen cycling. Initial results indicate that conifers are more sensitive than deeper-rooted deciduous species to variability in groundwater depth and meteorological conditions. Forest productivity also shows a non-linear response to groundwater depth. Sites with intermediate groundwater depths (0.2-0.5m) allow vegetation to maintain connectivity to groundwater over longer periods during the growing season, are effectively uncoupled from atmospheric constraints on photosynthesis, and generally have greater productivity. Shallow groundwater sites (<0.2m) are less productive due to the indirect effects of reduced soil aerobic decomposition and reduced plant available nitrogen.

  5. Dynamics of productivity change in the Australian electricity industry: Assessing the impacts of electricity reform

    International Nuclear Information System (INIS)

    Aghdam, Reza Fathollahzadeh

    2011-01-01

    The Australian electricity industry has undergone a significant reform, since the mid-1990s. Key changes comprised functional unbundling, market restructuring, regulatory reform, public corporatisation and privatisation. Technological development has been another indisputable constituent of these changes, in the wake of ICT revolution. The principle rationale behind these changes has been that they would improve productivity of the industry and social well-being of people. This paper examines the dynamics of productivity changes in the Australian electricity industry and conducts several hypotheses-testings to identify whether industry's efficiency measures are truly improved as a result of the reform-driven changes. Malmquist Total Factor Productivity Index approach and ANOVA are used for this purpose. The results reveal that the productivity gains in the industry have been largely driven by technological improvements and, to a lesser extent, by reform-induced comparative efficiency gains. On average at national level and for the entire industry, there are efficiency gains that, to large extents, can be attributed to functional unbundling and public corporatisation and, to a lesser extent, to market restructuring and privatisation. The results, however, reveal that the reform-driven changes have made insignificant contribution to comparative efficiency, at the level of thermal generation. - Highlights: → Dynamics of productivity changes in Australian electricity industry are examined. → Several hypotheses are also tested against reform-driven changes. → Technology impact is proved to be far larger than reform-induced impacts. → Unbundling and corporatisation had larger impacts than market restructuring and privatisation. → At thermal generation level, no reform-induced impact is encountered.

  6. Revealing dynamics and consequences of fit and misfit between formal and informal networks in multi-institutional product development collaborations

    NARCIS (Netherlands)

    Kratzer, J.; Gemuenden, Hans G.; Lettl, Christopher

    The study presents a longitudinal examination about dynamics and consequences of fit and misfit between formally ascribed design interfaces and informal communication networks in two large multi-institutional product development collaborations in space industry. Findings: (1) formally ascribed

  7. Assembling Toyota in Portugal

    OpenAIRE

    Machado, Tiago; Moniz, António

    2003-01-01

    A lot has been written over the last decade with regard to Toyota and the productive model associated to it (toyota-ism). And more specifically concerning the "(…) best-seller that changed the... sociological world" (Castillo, 1998: 31). But the case of Salvador Caetano’s Ovar Industrial Division (OID), that assembles Toyota light commercial vehicles in Portugal, allows us to put forward a sub-hypothesis that fits into the analysis schema proposed in the First GERPISA International Program – ...

  8. An integral analysis for second generation bioethanol production via a dynamic model-based simulation approach: stochastic nonlinear optimisation

    DEFF Research Database (Denmark)

    Morales Rodriguez, Ricardo; Meyer, Anne S.; Gernaey, Krist

    of cellulose, co-fermentation of sugars and downstream processes for purification and recovery of most value-added products. The dynamic model involves both the mass and energy balances coupled with constitutive dynamic equations to assess the process yield and energy efficiency of different bioethanol...

  9. Fuel assembly

    International Nuclear Information System (INIS)

    Fujibayashi, Toru.

    1970-01-01

    Herein disclosed is a fuel assembly in which a fuel rod bundle is easily detachable by rotating a fuel rod fastener rotatably mounted to the upper surface of an upper tie-plate supporting a fuel bundle therebelow. A locking portion at the leading end of each fuel rod protrudes through the upper tie-plate and is engaged with or separated from the tie-plate by the rotation of the fastener. The removal of a desired fuel rod can therefore be remotely accomplished without the necessity of handling pawls, locking washers and nuts. (Owens, K.J.)

  10. Assembling consumption

    DEFF Research Database (Denmark)

    Assembling Consumption marks a definitive step in the institutionalisation of qualitative business research. By gathering leading scholars and educators who study markets, marketing and consumption through the lenses of philosophy, sociology and anthropology, this book clarifies and applies...... the investigative tools offered by assemblage theory, actor-network theory and non-representational theory. Clear theoretical explanation and methodological innovation, alongside empirical applications of these emerging frameworks will offer readers new and refreshing perspectives on consumer culture and market...... societies. This is an essential reading for both seasoned scholars and advanced students of markets, economies and social forms of consumption....

  11. Validation of the standalone implementation of the dynamic wake meandering model for power production

    DEFF Research Database (Denmark)

    Keck, Rolf-Erik Henrik Jussi

    2015-01-01

    This paper presents validation for using the standalone implementation of the dynamic wake meandering (DWM) model to conduct numerical simulations of power production of rows of wind turbines. The standalone DWM model is an alternative formulation of the conventional DWM model that does not require...... information exchange with an aeroelastic code. As a consequence, the standalone DWM model has significantly shorter computational times and lower demands on the user environment. The drawback of the standalone DWM model is that it does not have the capability to predict turbine loads. Instead, it should...

  12. Mechanisms of defect production and atomic mixing in high energy displacement cascades: A molecular dynamics study

    International Nuclear Information System (INIS)

    Diaz de la Rubia, T.; Guinan, M.W.

    1991-01-01

    We have performed molecular dynamics computer simulation studies of displacement cascades in Cu at low temperature. For 25 keV recoils we observe the splitting of a cascade into subcascades and show that cascades in Cu may lead to the formation of vacancy and interstitial dislocation loops. We discuss a new mechanism of defect production based on the observation of interstitial prismatic dislocation loop punching from cascades at 10 K. We also show that below the subcascade threshold, atomic mixing in the cascade is recoil-energy dependent and obtain a mixing efficiency that scales as the square root of the primary recoil energy. 44 refs., 12 figs

  13. Working group II report: Production and dynamics of high brightness beams

    International Nuclear Information System (INIS)

    Sheffield, R.L.

    1996-01-01

    This paper summarizes the main discussions of the Working Group on the Production and Dynamics of High Brightness Beams. The following topics are covered in this paper. Proposed new electron sources and needed research on existing sources is covered. The discussions on issues relating to the description of phase space on non-thermalized electron beam distributions and the theoretical modeling on non-thermalized electron beam distributions is presented. Finally, the present status of the theoretical modeling of beam transport in bends is given

  14. Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.

    Directory of Open Access Journals (Sweden)

    Anja Eskat

    Full Text Available Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN, which contains a 5-subunit (CENP-P/O/R/Q/U sub-complex. Here we show using a fluorescent three-hybrid (F3H assay and fluorescence resonance energy transfer (FRET in living mammalian cells that CENP-P/O/R/Q/U subunits exist in a tightly packed arrangement that involves multifold protein-protein interactions. This sub-complex is, however, not pre-assembled in the cytoplasm, but rather assembled on kinetochores through the step-wise recruitment of CENP-O/P heterodimers and the CENP-P, -O, -R, -Q and -U single protein units. SNAP-tag experiments and immuno-staining indicate that these loading events occur during S-phase in a manner similar to the nucleosome binding components of the CCAN, CENP-T/W/N. Furthermore, CENP-P/O/R/Q/U binding to the CCAN is largely mediated through interactions with the CENP-N binding protein CENP-L as well as CENP-K. Once assembled, CENP-P/O/R/Q/U exchanges slowly with the free nucleoplasmic pool indicating a low off-rate for individual CENP-P/O/R/Q/U subunits. Surprisingly, we then find that during late S-phase, following the kinetochore-binding step, both CENP-Q and -U but not -R undergo oligomerization. We propose that CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation necessary for microtubule-attachment.

  15. CANDELS: THE COSMIC ASSEMBLY NEAR-INFRARED DEEP EXTRAGALACTIC LEGACY SURVEY—THE HUBBLE SPACE TELESCOPE OBSERVATIONS, IMAGING DATA PRODUCTS, AND MOSAICS

    International Nuclear Information System (INIS)

    Koekemoer, Anton M.; Ferguson, Henry C.; Grogin, Norman A.; Lotz, Jennifer M.; Lucas, Ray A.; Ogaz, Sara; Rajan, Abhijith; Casertano, Stefano; Dahlen, Tomas; Faber, S. M.; Kocevski, Dale D.; Koo, David C.; Lai, Kamson; McGrath, Elizabeth J.; Riess, Adam G.; Rodney, Steve A.; Dolch, Timothy; Strolger, Louis; Castellano, Marco; Dickinson, Mark

    2011-01-01

    This paper describes the Hubble Space Telescope imaging data products and data reduction procedures for the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). This survey is designed to document the evolution of galaxies and black holes at z ≈ 1.5-8, and to study Type Ia supernovae at z > 1.5. Five premier multi-wavelength sky regions are selected, each with extensive multi-wavelength observations. The primary CANDELS data consist of imaging obtained in the Wide Field Camera 3 infrared channel (WFC3/IR) and the WFC3 ultraviolet/optical channel, along with the Advanced Camera for Surveys (ACS). The CANDELS/Deep survey covers ∼125 arcmin 2 within GOODS-N and GOODS-S, while the remainder consists of the CANDELS/Wide survey, achieving a total of ∼800 arcmin 2 across GOODS and three additional fields (Extended Groth Strip, COSMOS, and Ultra-Deep Survey). We summarize the observational aspects of the survey as motivated by the scientific goals and present a detailed description of the data reduction procedures and products from the survey. Our data reduction methods utilize the most up-to-date calibration files and image combination procedures. We have paid special attention to correcting a range of instrumental effects, including charge transfer efficiency degradation for ACS, removal of electronic bias-striping present in ACS data after Servicing Mission 4, and persistence effects and other artifacts in WFC3/IR. For each field, we release mosaics for individual epochs and eventual mosaics containing data from all epochs combined, to facilitate photometric variability studies and the deepest possible photometry. A more detailed overview of the science goals and observational design of the survey are presented in a companion paper.

  16. Interfaz entre el plan de producción y el programa de producción en ambientes de ensamble Interface between the production plan and the master production schedule in assembly environments

    Directory of Open Access Journals (Sweden)

    Marcos Moya Navarro

    2012-11-01

    Full Text Available En un entorno de producción existe una relación directa entre el mercado y los procesos de manufactura de los bienes. Sin embargo, cuando la producción está inmersa en un ambiente de ensamble, el procedimiento de la planificación y la programación se vuelve complejo, con el riesgo de que la empresa pierda ventaja competitiva en términos de incumplimiento de las fechas de entrega y elevados costos de planificación y control. La programación lineal constituye una herramienta apropiada para construir modelos de programación y control de la producción en entornos de manufactura complejos. El objetivo de este trabajo es mostrar la interfaz entre el plan de producción y el programa de producción en ambientes de ensamble mediante el modelado por programación lineal. Para ello, se seleccionó un entorno que produce tres productos finales cuya estructura de producto está dispuesta en tres niveles con un máximo de ocho componentes. Los datos proporcionados por el plan de producción se desglosaron en diez órdenes, cada una indicando el tipo de producto, la cantidad por producir y su respectiva fecha de entrega. Los resultados obtenidos en el programa de producción establecieron la recepción de pedidos planificados y el programa de componentes totales requeridos en cada periodo de producción, para minimizar los costos totales de emisión de órdenes de producción e inventario.In a production environment there is a direct relationship between the market and the manufacturing process of goods.When production is immersed in an assembly environment, the process of production planning and scheduling becomes complex, and the enterprises have the risk of losing competitive advantages in terms of not meeting delivery dates and production high costs. Linear programming has become an appropriate tool for production planning and scheduling in complex manufacturing environments. The aim of this paper is to show the interface between both the

  17. An informatics model for guiding assembly of telemicrobiology workstations for malaria collaborative diagnostics using commodity products and open-source software

    Directory of Open Access Journals (Sweden)

    Crandall Ian

    2009-07-01

    Full Text Available Abstract Background Deficits in clinical microbiology infrastructure exacerbate global infectious disease burdens. This paper examines how commodity computation, communication, and measurement products combined with open-source analysis and communication applications can be incorporated into laboratory medicine microbiology protocols. Those commodity components are all now sourceable globally. An informatics model is presented for guiding the use of low-cost commodity components and free software in the assembly of clinically useful and usable telemicrobiology workstations. Methods The model incorporates two general principles: 1 collaborative diagnostics, where free and open communication and networking applications are used to link distributed collaborators for reciprocal assistance in organizing and interpreting digital diagnostic data; and 2 commodity engineering, which leverages globally available consumer electronics and open-source informatics applications, to build generic open systems that measure needed information in ways substantially equivalent to more complex proprietary systems. Routine microscopic examination of Giemsa and fluorescently stained blood smears for diagnosing malaria is used as an example to validate the model. Results The model is used as a constraint-based guide for the design, assembly, and testing of a functioning, open, and commoditized telemicroscopy system that supports distributed acquisition, exploration, analysis, interpretation, and reporting of digital microscopy images of stained malarial blood smears while also supporting remote diagnostic tracking, quality assessment and diagnostic process development. Conclusion The open telemicroscopy workstation design and use-process described here can address clinical microbiology infrastructure deficits in an economically sound and sustainable manner. It can boost capacity to deal with comprehensive measurement of disease and care outcomes in individuals and

  18. An informatics model for guiding assembly of telemicrobiology workstations for malaria collaborative diagnostics using commodity products and open-source software.

    Science.gov (United States)

    Suhanic, West; Crandall, Ian; Pennefather, Peter

    2009-07-17

    Deficits in clinical microbiology infrastructure exacerbate global infectious disease burdens. This paper examines how commodity computation, communication, and measurement products combined with open-source analysis and communication applications can be incorporated into laboratory medicine microbiology protocols. Those commodity components are all now sourceable globally. An informatics model is presented for guiding the use of low-cost commodity components and free software in the assembly of clinically useful and usable telemicrobiology workstations. The model incorporates two general principles: 1) collaborative diagnostics, where free and open communication and networking applications are used to link distributed collaborators for reciprocal assistance in organizing and interpreting digital diagnostic data; and 2) commodity engineering, which leverages globally available consumer electronics and open-source informatics applications, to build generic open systems that measure needed information in ways substantially equivalent to more complex proprietary systems. Routine microscopic examination of Giemsa and fluorescently stained blood smears for diagnosing malaria is used as an example to validate the model. The model is used as a constraint-based guide for the design, assembly, and testing of a functioning, open, and commoditized telemicroscopy system that supports distributed acquisition, exploration, analysis, interpretation, and reporting of digital microscopy images of stained malarial blood smears while also supporting remote diagnostic tracking, quality assessment and diagnostic process development. The open telemicroscopy workstation design and use-process described here can address clinical microbiology infrastructure deficits in an economically sound and sustainable manner. It can boost capacity to deal with comprehensive measurement of disease and care outcomes in individuals and groups in a distributed and collaborative fashion. The workstation

  19. Dynamic optimization of the complex adaptive controlling by the structure of enterprise’s product range

    Directory of Open Access Journals (Sweden)

    Andrey Fyodorovich Shorikov

    2013-06-01

    Full Text Available This paper reviews a methodical approach to solve multi-step dynamic problem of optimal integrated adaptive management of a product portfolio structure of the enterprise. For the organization of optimal adaptive terminal control of the system the recurrent algorithm, which reduces an initial multistage problem to the realization of the final sequence of problems of optimal program terminal control is offered. In turn, the decision of each problem of optimal program terminal control is reduced to the realization of the final sequence only single-step operations in the form of the problems solving of linear and convex mathematical programming. Thus, the offered approach allows to develop management solutions at current information support, which consider feedback, and which create the optimal structure of an enterprise’s product lines, contributing to optimising of profits, as well as maintenance of the desired level of profit for a long period of time

  20. Yeast dynamics during spontaneous fermentation of mawe and tchoukoutou, two traditional products from Benin

    DEFF Research Database (Denmark)

    Greppi, Anna; Rantisou, Kalliopi; Padonou, Wilfrid

    2013-01-01

    Mawe and tchoukoutou are two traditional fermented foods largely consumed in Benin, West Africa. Their preparations remain as a house art and they are the result of spontaneous fermentation processes. In this study, dynamics of the yeast populations occurring during spontaneous fermentations...... of mawe and tchoukoutou were investigated using both culture-dependent and -independent approaches. For each product, two productions were followed. Samples were taken at different fermentation times and yeasts were isolated, resulting in the collection of 177 isolates. They were identified by the PCR......-DGGE technique followed by the sequencing of the D1/D2 domain of the 26S rRNA gene. The predominant yeast species identified were typed by rep-PCR. Candida krusei was the predominant yeast species in mawe fermentation followed by Candida glabrata and Kluyveromyces marxianus. Other yeast species were detected...