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Sample records for dura mater

  1. Permeability of dura mater

    DEFF Research Database (Denmark)

    Tfelt-Hansen, Peer Carsten

    2011-01-01

    In the wake of cortical spreading depression (CSD) it has been suggested that noxious substances diffuse through the dura with resulting firing of epidural nerves. In my view this is unlikely because there are good reasons to suggest that there must be a dura-brain barrier. Alternatively collater...

  2. Histological investigation of resected dura mater attached to spinal meningioma.

    Science.gov (United States)

    Yamamuro, Kenichi; Seichi, Atsushi; Kimura, Atsushi; Kikkawa, Ichiro; Kojima, Masahiro; Inoue, Hirokazu; Hoshino, Yuichi

    2012-10-15

    Histological observational study of patients with spinal meningioma. To clarify the status of tumor cell invasion into the dura mater and to provide fundamental information for appropriate management of dural attachment. Histological appearance of the dura attached to spinal meningioma has not been sufficiently evaluated. Dura mater resected in a Simpson Grade 1 manner from 25 consecutive patients with spinal meningiomas (World Health Organization grade 1) was histologically observed to determine the status of tumor cell invasion. As no clear borders such as a tumor capsule between tumor and dura mater were observed, histological findings of the dura mater were classified into the following 3 categories: grade 1, no dural invasion, with only inflammation of the dura; grade 2: dural invasion below the zone between the inner and outer layers; and grade 3, dural invasion into or over the zone between the inner and outer layers (full-thickness invasion). In our microscopic study, 19 of the 25 cases of spinal meningioma showed evidence of dural invasion and 15 cases showed full-thickness invasion. This histological investigation of resected dura mater attached to spinal meningioma showed a high rate of full-thickness tumor invasion into the dura mater.

  3. Electronic dura mater for long-term multimodal neural interfaces

    Science.gov (United States)

    Minev, Ivan R.; Musienko, Pavel; Hirsch, Arthur; Barraud, Quentin; Wenger, Nikolaus; Moraud, Eduardo Martin; Gandar, Jérôme; Capogrosso, Marco; Milekovic, Tomislav; Asboth, Léonie; Torres, Rafael Fajardo; Vachicouras, Nicolas; Liu, Qihan; Pavlova, Natalia; Duis, Simone; Larmagnac, Alexandre; Vörös, Janos; Micera, Silvestro; Suo, Zhigang; Courtine, Grégoire; Lacour, Stéphanie P.

    2015-01-01

    The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.

  4. Viscoelastic finite-element analysis of human skull - dura mater ...

    African Journals Online (AJOL)

    SERVER

    2008-03-18

    Mar 18, 2008 ... In the work, the dynamic characteristics of the human skull-dura mater ... Ansys' finite element processor, a simplified three-dimensional finite element ... brain, cerebrospinal fluid (CSF), and the brain's blood ... ICP is often not preventable. .... The creep of linear viscoelastic solid can be simulated by the.

  5. Random Forests for Dura Mater Microvasculature Segmentation Using Epifluorescence Images.

    Science.gov (United States)

    Kassim, Yasmin M; Surya Prasath, V B; Pelapur, Rengarajan; Glinskii, Olga V; Maude, Richard J; Glinsky, Vladislav V; Huxley, Virginia H; Palaniappan, Kannappan

    2016-08-01

    Automatic segmentation of microvascular structures is a critical step in quantitatively characterizing vessel remodeling and other physiological changes in the dura mater or other tissues. We developed a supervised random forest (RF) classifier for segmenting thin vessel structures using multiscale features based on Hessian, oriented second derivatives, Laplacian of Gaussian and line features. The latter multiscale line detector feature helps in detecting and connecting faint vessel structures that would otherwise be missed. Experimental results on epifluorescence imagery show that the RF approach produces foreground vessel regions that are almost 20 and 25 percent better than Niblack and Otsu threshold-based segmentations respectively.

  6. Cavernous hemangioma of the dura mater mimicking meningioma

    Science.gov (United States)

    Di Vitantonio, Hambra; De Paulis, Danilo; Ricci, Alessandro; Marzi, Sara; Dehcordi, Soheila Raysi; Galzio, Renato Juan

    2015-01-01

    Background: Cavernomas are benign lesions that most commonly occur intra-parenchymally, but occasionally they have been described as arising from the dura mater. Extra-axial cavernous angiomas (or hemangiomas) account for 0.4–2% of all intracranial vascular malformations, and they usually occur in the middle cranial fossa, associated with the cavernous sinus. Other possible localizations (e.g. tentorium, convexity, anterior cranial fossa, cerebellopontine angle, Meckel's cave, sella turcica and internal auditory meatus) are rare, and they account only for 0.2–0.5%. Case Description: We report a case of a 30-year-old female presenting with a 2 years history of headache unresponsive to drug therapy. The magnetic resonance imaging showed a dural-based lesion in the left frontal region; the lesion size was: 1.5 cm × 3.5 cm. The appearance suggested a convexity meningioma. A left frontal craniotomy was performed, and the histopathological diagnosis deposed for a cavernous hemangioma of the dura mater. The follow-up at 1-year was good without any neurologic deficit. Conclusions: Dural-based cavernous hemangiomas of the convexity are uncommon lesions. Up to now, only 13 cases have been described in the literature. The authors have discussed clinical aspects, radiological features, surgical treatment, and operative findings. PMID:26421218

  7. Treatment for infection of artificial dura mater using free fascia lata.

    Science.gov (United States)

    Nakano, Takashi; Yoshikawa, Katsuhiro; Kunieda, Takeharu; Arakawa, Yoshiki; Kikuchi, Takayuki; Yamawaki, Satoko; Naitoh, Motoko; Kawai, Katsuya; Suzuki, Shigehiko

    2014-07-01

    Synthetic artificial dura mater materials, such as expanded polytetrafluoroethylene sheets, are widely used in dura mater reconstruction in cases involving brain tumors or trauma surgery. In patients with postoperative infection related to the use of artificial dura mater, surgical debridement of the infected wound and removal of the artificial dura mater materials are necessary to control infection. In cases involving cerebrospinal fluid leakage, dura mater reconstruction must be performed immediately. Many useful techniques for performing dura mater reconstruction to treat postoperative infection have been reported; however, some have drawbacks with respect to the need for microvascular anastomosis or difficulties in obtaining watertight closure. We successfully treated 6 patients with postoperative artificial dura mater infection using free thigh fascia lata. Some surgeons believe that the use of free fascia in infected wounds is dangerous because free fascia is a non-vascularized tissue. However, performing complete debridement and covering such free fascia with well-vascularized tissue allow the fascia to become vascularized and tolerant of infection. Therefore, if the blood flow in the scalp is acceptable after a sufficient debridement, free fascia lata can be used for reconstruction in patients with postoperative infection of artificial dura mater. Furthermore, skull reconstruction can be performed safely and easily with solid-type artificial bone, sometimes combined with tissue expansion, thus resulting in good aesthetic outcomes.

  8. Cranial Reconstruction following the Removal of an Infected Synthetic Dura Mater Substitute

    Directory of Open Access Journals (Sweden)

    Nobutaka Yoshioka, MD

    2014-04-01

    Conclusions: Staged cranial reconstruction after the removal of an infected synthetic dura mater substitute using an algorithmic approach is feasible and safe, produces satisfactory cosmetic results, and is not associated with any complications.

  9. Evidence for CGRP re-uptake in rat dura mater encephali

    DEFF Research Database (Denmark)

    Gupta, Saurabh; Amrutkar, Dipak Vasantrao; Mataji, Aydin;

    2010-01-01

    Calcitonin gene-related peptide (CGRP) is widely distributed in the trigeminovascular system and released from sensory fibres of the cranial dura mater upon noxious stimulation. Such release may be a mechanism underlying migraine headache. Based on data from guinea pig basilar artery preparations...

  10. Microvascular anatomy of spinal dural arteriovenous fistulas: arteriovenous connections and their relationships with the dura mater.

    Science.gov (United States)

    Takai, Keisuke; Komori, Takashi; Taniguchi, Makoto

    2015-10-01

    OBJECT The microvascular anatomy of spinal dural arteriovenous fistulas (AVFs), especially the relationships of the vessels with the dura mater, has yet to be angiographically demonstrated in detail and proven histologically. METHODS From January 2012 through April 2014, a total of 7 patients with spinal dural AVFs in the thoracic region underwent open microsurgical obliteration at Tokyo Metropolitan Neurological Hospital. The microvascular anatomy of spinal dural AVFs was comprehensively assessed by using advanced microangiography, including 3D computer graphics and intraoperative indocyanine green video angiography, and by histological findings. RESULTS The 2 microangiography techniques revealed the spatial course and in vivo blood flow of the meningeal vessels and their relationships with the dura mater in sufficient detail. The meningeal branch of the intercostal artery split into multiple meningeal vessels on the outer dural surface adjacent to the root sleeve. After crossing the dura mater to the inner dural surface, these vessels gathered and joined a single intradural draining vessel. On the inner dural surface, the single draining vessel was fed by the surrounding multiple meningeal vessels, which appeared to be caput medusae. Histological findings revealed that the structure of the meningeal branch of the intercostal artery corresponded to that of a normal artery. The structure of intradural draining vessels corresponded to that of a vein modified by retrograde arterial inflow. On the inner dural surface, more than 1 meningeal artery gathered and joined with the proximal radiculomedullary vein. CONCLUSIONS Spinal dural AVFs are located on the inner dural surface, where multiple direct AV connections between more than 1 meningeal feeding artery and a single proximal radiculomedullary vein occur at the site where the vein connects to the dura mater.

  11. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Hoon; Lee, Ji Hoon; Ko, Yong; Paik, Seoung Sam; Lee, Young Jun [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of); Park, Dong Woo [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement.

  12. Use of equine pericardium sheet (LYOMESH®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery

    Science.gov (United States)

    Cavallo, Luigi M.; Solari, Domenico; Somma, Teresa; Di Somma, Alberto; Chiaramonte, Carmela; Cappabianca, Paolo

    Objective The aim of this study was to describe the use of equine pericardium sheet (Lyomesh ® ) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary adenomas. Methods We reviewed data of patients that underwent surgery by means of an endoscopic endonasal transsphenoidal approach for the removal of pituitary adenomas over a 12-months period, starting in May 2012, i.e. when we adopted Lyomesh ® (Audio Technologies, Piacenza, Italy) an equine pericardium sheet, as dura mater substitute. Results: During the 12-months period evaluated, we performed an endoscopic endonasal transsphenoidal operation for a variety of pituitary lesions on 102 consecutive patients. Among these, in 12 patients (9.4%) harboring a pituitary adenoma, the implant of the pericardium sheet was used. Four patients (33.3%) presented a small intraoperative cerebrospinal fluid (CSF) leak; in these cases the Lyomesh ® was placed intradurally with fibrin glue and, thereafter, several layers were positioned in extradural space. In 8 other subjects without any evidence of CSF leak, the dural substitute was placed intradurally and fibrin glue was injected intradurally to hold the material in place. Conclusions: Even if based on a relatively small patient series, our experience demonstrated that the use of equine pericardium sheet (Lyomesh ® ) as dura mater substitute in transsphenoidal surgery is safe and biocompatible, as compared with other dural substitutes. PMID:24251248

  13. Cannula-aided penetration: a simple method to insert structurally weak electrodes into brain through the dura mater.

    Science.gov (United States)

    Matsuzaka, Yoshiya; Sakamoto, Kazuhiro; Tanaka, Tetsu; Furusawa, Yoshihito; Mushiake, Hajime

    2009-09-01

    We developed a simple and inexpensive method to insert structurally weak electrodes into the brain through the thickened dura mater in chronic animal experiments. It uses a commonly available intravenous (IV) needle and a cannula to secure a small puncture in the dura mater, through which an electrode is advanced into the underlying cerebral cortex. In addition to its simplicity and cost-effectiveness, this method provides greater degree of freedom regarding the shape and the placement of electrodes compared to the conventional guide tube systems.

  14. Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis

    DEFF Research Database (Denmark)

    Lukács, M; Warfvinge, K; Tajti, J

    2017-01-01

    BACKGROUND: Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund's Adjuvant (CFA) onto the dura mater caused activation in rat trigeminal ganglion (TG) which was abolished by a s...

  15. Research Status of the Artiifcial Dura Mater%人工硬脑膜材料的研究现状

    Institute of Scientific and Technical Information of China (English)

    张宇杭; 胥光申

    2016-01-01

    在神经外科手术中,硬脑膜替代物对于维持解剖学的完整和脑组织保护是十分重要的。近年来,随着组织工程和生物材料研究技术的发展,人工硬脑膜的研究取得许多进展。本文对人工硬脑膜国内外的相关文献进行了检索和综合分析,并展望了未来人工硬脑膜研究重点和发展方向。%Dura mater substitutes are of great importance in keeping anatomies intact and protecting brain tissue in neurosurgical operations. With the continuous development of tissue engineering and biomaterials in recent years, the research progress of the artiifcial dural materials has made remarkable progress. In this paper, the related literature about dura mater both at home and abroad were searched and analyzed comprehensively. The paper also examined the prospect of the focus and development direction of dura mater in the future research.

  16. Vertical osteoconductivity of sputtered hydroxyapatite-coated mini titanium implants after dura mater elevation: Rabbit calvarial model.

    Science.gov (United States)

    Wang, Xin; Zakaria, Osama; Madi, Marwa; Kasugai, Shohei

    2015-01-01

    This study evaluated the quantity and quality of newly formed vertical bone induced by sputtered hydroxyapatite-coated titanium implants compared with sandblasted acid-etched implants after dura mater elevation. Hydroxyapatite-coated and non-coated implants (n = 20/group) were used and divided equally into two groups. All implants were randomly placed into rabbit calvarial bone (four implants for each animal) emerging from the inferior cortical layer, displacing the dura mater 3 mm below the original bone. Animals were sacrificed at 4 (n = 5) and 8 (n = 5) weeks post-surgery. Vertical bone height and area were analyzed histologically and radiographically below the original bone. Vertical bone formation was observed in both groups. At 4 and 8 weeks, vertical bone height reached a significantly higher level in the hydroxyapatite compared with the non-coated group (p Vertical bone area was significantly larger in the hydroxyapatite compared with the non-coated group at 4 and 8 weeks (p vertical bone formation can be induced by dura mater elevation and sputtered hydroxyapatite coating can enhance vertical bone formation.

  17. Preliminary exploration of the development of a collagenous artificial dura mater for sustained antibiotic release

    Institute of Scientific and Technical Information of China (English)

    WANG Hao; DONG Hui; KANG Cheng-gui; LIN Cheng; YE Xun; ZHAO Yuan-li

    2013-01-01

    Background Intracranial infection is one of the most common complications of open craniocerebral injury and of conventional craniotomy in neurosurgery.The presence of blood-brain barrier leads to lower drug concentrations in the cerebrospinal fluid than in the venous blood.Increasing the intravenous dosage or frequency carries the risk of systemic adverse reactions or infections in other parts of the body.Developing an artificial dura mater (ADM) for sustained antibiotic release for use during neurosurgery can solve the problems perfectly.Methods Three types of drug-loaded ADMs made of collagen and containing cefuroxime sodium,ceftriaxone sodium,or norvancomycin were prepared.The antibacterial activity and sustained release characteristics of the ADMs were examined using bacteriostatic and release tests.Results Single-layered collagen based ADMs (40 mm×50 mm×5 mm) containing 18 mg cefuroxime sodium or ceftriaxone sodium were not suitable for continued development because of drug preservation and stability issues.Using smaller ADMs (20 mm×30 mm×7 mm),containing 4.86 mg of norvancomycin,with increased collagen density and a three-layered film with two outer drug-free films above and below the antibiotic layer resulted in sustained cumulative release of 2.91 mg (59.9%) of norvancomycin over 72 hours.The similar factor (f2) comparison method proved that products from a same batch were statistically significant similar (f2 >50).Conclusions Artificial ADMs made of collagen can be processed to provide a mature dural repair material for the sustained release of norvancomycin.This system may provide a basis for developing sustained release materials for other drugs.

  18. Vacuum-assisted closure for complex cranial wounds involving the loss of dura mater.

    Science.gov (United States)

    Powers, Alexander K; Neal, Matthew T; Argenta, Louis C; Wilson, John A; DeFranzo, Anthony J; Tatter, Stephen B

    2013-02-01

    The aim in this study was to describe the safety and efficacy of vacuum-assisted closure (VAC) in patients with complex cranial wounds with extensive scalp, bone, and dural defects who were not candidates for immediate free tissue transfer. Five patients (4 men and 1 woman) ages 24-73 years with complex cranial wounds were treated with VAC at Wake Forest Baptist Medical Center. Etiologies included trauma, squamous cell carcinoma, and malignant meningioma. Cutaneous wound defects measured as large as 15 cm in diameter. Four of the 5 patients had open skull defects with concomitant dural defects, and 1 patient had dural dehiscence. After surgical debridement, all 5 patients were treated with the direct application of a VAC device to a reapproximated dura mater (1 patient), to a pericranial flap (1 patient), or to a regenerative tissue matrix overlying CNS tissue (3 patients). In all cases involving open cranial wounds, the VAC device promoted granulation tissue formation over the dural substitute, prevented CSF leakage, and kept the wounds free from local infection. The duration of VAC therapy ranged from 16 to 91 days. Although VAC therapy was intended as a temporary measure until these patients could be stabilized for larger tissue transfer procedures or they succumbed to their primary pathology, 1 patient had a successful skin graft following VAC therapy. Hydrocephalus requiring shunt placement developed in 2 patients during VAC therapy. The VAC dressings applied to a tissue matrix or other barrier over brain tissue in extensive cranial wounds are safe and well tolerated, providing a functional barrier and preventing infection.

  19. Idiopathic spinal cord herniation with duplicated dura mater and dorsal subarachnoid septum. Report of a case and review of the literature

    Science.gov (United States)

    Yamamoto, Norio; Higashino, Kousaku; Sairyo, Koichi

    2014-01-01

    Background Idiopathic spinal cord herniation (ISCH) is a rare condition and its pathogenesis remains unclear. The purpose of this case report is to present an ISCH case with dorsal subarachnoid septum suggesting the pathogenesis of ISCH being adhesions from preexisting inflammation. Methods Single case report. Results A 60-year-old woman presented with Brown-Séquard syndrome below the level of T6. Magnetic resonance imaging revealed the thoracic spinal cord was displaced ventrally, and the dorsal subarachnoid space was enlarged and had a septum between the spinal cord and dura mater. Intraoperatively, the dorsal dura mater was seen to be adherent and the subarachnoid septum was identified after durotomy. The inner layer defect of the duplicated dura mater was found in the ventral dura mater, through which the spinal cord had herniated. After releasing the septum, the adhesions around the dura mater, and the hiatus, the spinal cord was reduced. Conclusions The present case indicates that adhesions around the dura mater can be the pathogenesis of ISCH. PMID:25694934

  20. Diet-Induced Obesity Enhances TRPV1-Mediated Neurovascular Reactions in the Dura Mater.

    Science.gov (United States)

    Marics, Balázs; Peitl, Barna; Pázmándi, Kitti; Bácsi, Attila; Németh, József; Oszlács, Orsolya; Jancsó, Gábor; Dux, Mária

    2017-03-01

    Exploring the pathophysiological changes in transient receptor potential vanilloid 1 (TRPV1) receptor of the trigeminovascular system in high-fat, high-sucrose (HFHS) diet-induced obesity of experimental animals. Clinical and experimental observations suggest a link between obesity and migraine. Accumulating evidence indicates that metabolic and immunological alterations associated with obesity may potentially modulate trigeminovascular functions. A possible target for obesity-induced pathophysiological changes is the TRPV1/capsaicin receptor which is implicated in the pathomechanism of headaches in a complex way. Male Sprague-Dawley rats were fed a regular (n = 25) or HFHS diet (n = 26) for 20 weeks. At the end of the dietary period, body weight of the animals was normally distributed in both groups and it was significantly higher in animals on HFHS diet. Therefore, experimental groups were regarded as control and HFHS diet-induced obese groups. Capsaicin-induced changes in meningeal blood flow and release of calcitonin gene-related peptide (CGRP) from dural trigeminal afferents were measured in control and obese rats. The distribution of TRPV1- and CGRP-immunoreactive meningeal sensory nerves was also compared in whole mount preparations of the dura mater. Metabolic parameters of the animals were assessed by examining glucose and insulin homeostasis as well as plasma cytokine concentrations. HFHS diet was accompanied by reduced food consumption and greater fluid and energy intakes in addition to increased body weight of the animals. HFHS diet increased fasting blood glucose and insulin concentrations as well as levels of circulating proinflammatory cytokines interleukin-1β and interleukin-6. In obese animals, dural application of the archetypal TRPV1 agonist capsaicin resulted in significantly augmented vasodilatory and vasoconstrictor responses as compared to controls. Diet-induced obesity was also associated with enhanced basal and capsaicin

  1. Characterization and morphological comparison of human dura mater, temporalis fascia, and pericranium for the correct selection of an autograft in duraplasty procedures.

    Science.gov (United States)

    Morales-Avalos, Rodolfo; Soto-Domínguez, Adolfo; García-Juárez, Jaime; Saucedo-Cardenas, Odila; Bonilla-Galvan, José R; Cardenas-Serna, Marcela; Guzmán-López, Santos; Elizondo-Omaña, Rodrigo E

    2017-01-01

    The objective of this study was to characterize and compare the morphological characteristics of the dura mater, the pericranium, and the temporal fascia to ascertain the most adequate tissue to use as a dura graft. 20 dura mater, 20 pericranium and 20 temporalis fascia samples were analyzed. Each of the samples was stained with hematoxylin and eosin, orcein, Van Gieson, Masson's trichrome and Verhoeff-Van Gieson (600 slides in total) for a general morphological evaluation, as well as a quantitative, morphometric and densitometric analysis of elastic fibers present in each of the tissues. The micro-densitometric analysis of the tissues indicated that the area occupied by the elastic fibers showed values of 1.766 ± 1.376, 4.580 ± 3.041, and 8.253 ± 4.467 % for the dura mater, the temporalis fascia and the pericranium, respectively (p fascia and the pericranium, respectively (p fascia and dura mater vs. pericranium). This is the first study to compare the dura mater with tissues for dural autograft and to quantify the elastic component present in these tissues. The results indicate that the temporalis fascia is a better dural graft because of its intrinsic tissue properties.

  2. Laser bonding with ICG-infused chitosan patches: preliminary experiences in suine dura mater and vocal folds

    Science.gov (United States)

    Rossi, Francesca; Matteini, Paolo; Ratto, Fulvio; Pini, Roberto; Iacoangeli, Maurizio; Giannoni, Luca; Fortuna, Damiano; Di Cicco, Emiliano; Corbara, Sylwia; Dallari, Stefano

    2014-05-01

    Laser bonding is a promising minimally invasive approach, emerging as a valid alternative to conventional suturing techniques. It shows widely demonstrated advantages in wound treatment: immediate closuring effect, minimal inflammatory response and scar formation, reduced healing time. This laser based technique can overcome the difficulties in working through narrow surgical corridors (e.g. the modern "key-hole" surgery as well as the endoscopy setting) or in thin tissues that are impossible to treat with staples and/or stitches. We recently proposed the use of chitosan matrices, stained with conventional chromophores, to be used in laser bonding of vascular tissue. In this work we propose the same procedure to perform laser bonding of vocal folds and dura mater repair. Laser bonding of vocal folds is proposed to avoid the development of adhesions (synechiae), after conventional or CO2 laser surgery. Laser bonding application in neurosurgery is proposed for the treatment of dural defects being the Cerebro Spinal Fluid leaks still a major issue. Vocal folds and dura mater were harvested from 9-months old porks and used in the experimental sessions within 4 hours after sacrifice. In vocal folds treatment, an IdocyanineGreen-infused chitosan patch was applied onto the anterior commissure, while the dura mater was previously incised and then bonded. A diode laser emitting at 810 nm, equipped with a 600 μm diameter optical fiber was used to weld the patch onto the tissue, by delivering single laser spots to induce local patch/tissue adhesion. The result is an immediate adhesion of the patch to the tissue. Standard histology was performed, in order to study the induced photothermal effect at the bonding sites. This preliminary experimental activity shows the advantages of the proposed technique in respect to standard surgery: simplification of the procedure; decreased foreign-body reaction; reduced inflammatory response; reduced operating times and better handling in

  3. Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study

    Directory of Open Access Journals (Sweden)

    Iraklis Papageorgiou

    2014-06-01

    Full Text Available Medical interventions for the treatment of spinal disc degeneration include total disc replacement and fusion devices. There are, however, concerns regarding the generation of wear particles by these devices, the majority of which are in the nanometre sized range with the potential to cause adverse biological effects in the surrounding tissues. The aims of this study were to develop an organ culture model of the porcine dura mater and to investigate the biological effects of CoCr nanoparticles in this model. A range of histological techniques were used to analyse the structure of the tissue in the organ culture. The biological effects of the CoCr wear particles and the subsequent structural changes were assessed using tissue viability assays, cytokine assays, histology, immunohistochemistry, and TEM imaging. The physiological structure of the dura mater remained unchanged during the seven days of in vitro culture. There was no significant loss of cell viability. After exposure of the organ culture to CoCr nanoparticles, there was significant loosening of the epithelial layer, as well as the underlying collagen matrix. TEM imaging confirmed these structural alterations. These structural alterations were attributed to the production of MMP-1, -3, -9, -13, and TIMP-1. ELISA analysis revealed that there was significant release of cytokines including IL-8, IL-6, TNF-α, ECP and also the matrix protein, tenascin-C. This study suggested that CoCr nanoparticles did not cause cytotoxicity in the dura mater but they caused significant alterations to its structural integrity that could lead to significant secondary effects due to nanoparticle penetration, such as inflammation to the local neural tissue.

  4. Visualisation of the intact dura mater and brain surface in infant autopsies: a minimally destructive technique for the post-mortem assessment of head injury.

    Science.gov (United States)

    Cheshire, Emma C; Malcomson, Roger D G; Rutty, Guy N; James, Deryk S

    2015-03-01

    During the post-mortem examination of babies and young children, it is important to be able to visualise the brain and its coverings, particularly in cases where a head injury is likely to have occurred. In this paper, we present an improved method for removal of the calvarial bones in infant autopsies to enable viewing of the dura mater and brain. In contrast to the standard post-mortem procedure for observing and removing the brain, this novel technique is minimally disruptive, allowing the dura mater to remain undamaged. Specialised paediatric neurosurgical tools were used to remove the skull bones from 23 neonates, infants and young children during post-mortem examination. In 21 of our 23 cases, the calvarial bones were removed successfully with the dura mater remaining intact. In one case, there was a thickening of the dura mater which created a strong adherence of this membrane to the bone. In another case, the dura mater was slightly damaged due to the inexperience of the operator in using the neurosurgical tools. This method of calvarial bone removal reduces the degree of post-mortem artefact and enhances the ability to observe and photographically document autopsy findings, including the artefact-free detection of signs of injury such as epidural or subdural haematoma, and brain swelling. This technique has now become a routine practise in both of our units to remove the skull bones in infant/young children post-mortem examinations.

  5. Reparación de la duramadre con poliesteruretano Repair of dura mater with polyesterurethane

    Directory of Open Access Journals (Sweden)

    K Barbosa

    2005-03-01

    were excluded. The clinical observations were made a day after surgery, at 15 and 90 days later to find signs of filtration of cerebrospinal fluid, wound infection and meningitis. Results: Neither filtration of the cerebrospinal fluid nor infection was found in any of the 30 patients (craniotomy 53.3 %, craniectomy 3.3 %, repair of depressed fractures of the cranium 20 %, repair of lumbar myelomeningocele 6.7 %, instrumentation and fusion of thoracolumbar spine 3.3 %, thoracic laminectomy 3.3 %, lumbar laminectomies 6.7 %, and lumbar discectomy 3.3 %. In a patient that was reoperated on (relapse due to cerebral metastasis, there were not observed adherences of the graft to the cortical surface. Conclusions: It seems that polyesterutherane is an appropriate dural substitute that can be easily manipulated (and in this case with no cost and that produces a hermetic closure of the dura mater without complications or adherences to the cortical surface. Key words: Duroplasty, dural substitute, polyesterurethane

  6. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, S.; Saito, K.; Moskowitz, M.A.

    1987-12-01

    Utilizing /sup 125/I-BSA administered intravenously, a simple, reliable, and sensitive method was established for the detection of plasma protein extravasation in the dura of rats and guinea pigs following chemical, electrical, or immunological stimulation. Extravasated /sup 125/I-BSA or Evans blue was noted in the dura and conjunctiva but not in the temporalis muscle of saline-perfused rats following intravenous capsaicin, 1 mumol/kg. Capsaicin-induced extravasation was mediated by unmyelinated and small myelinated fibers since leakage did not develop in adult animals in whom these fibers were destroyed by capsaicin pretreatment (50 mg/kg) as neonates. An ipsilateral increase in Evans blue and /sup 125/I-BSA was found in the dura, eyelids, lips and gingival mucosa, and snout following electrical stimulation of the rat trigeminal ganglion. This increase was also C-fiber dependent. Among those peptides contained in perivascular afferent fibers and administered intravenously, substance P (SP) and neurokinin A (NKA), but not calcitonin gene-related peptide, caused a dose-dependent extravasation in the dura and conjunctiva of rats. Neonatal capsaicin pretreatment did not attenuate SP- nor NKA-induced effects in the dura and actually increased extravasation in the conjunctiva. Intravenous administration of 5-HT or bradykinin to normal adult rats or adult rats pretreated as neonates with capsaicin increased levels of /sup 125/I-BSA in both the dura and the conjunctiva. Histamine and prostaglandin E2, on the other hand, caused protein leakage in the conjunctiva but not in the dura of rats; however, histamine did induce extravasation in the dura of guinea pigs.

  7. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    Science.gov (United States)

    Filatova, S. A.; Kamynin, V. A.; Ryabova, A. V.; Loshchenov, V. B.; Zelenkov, P. V.; Zolotovskii, I. O.; Tsvetkov, V. B.; Kurkov, A. S.

    2015-08-01

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone.

  8. Intraventricular pneumocephalus after accidental perforation of the dura mater. Case report

    OpenAIRE

    2006-01-01

    JUSTIFICATIVA E OBJETIVOS: O uso de ar para a realização do teste da perda da resistência com a finalidade de identificar o espaço peridural é extremamente difundido no mundo inteiro, porém uma das complicações possíveis é a perfuração acidental de dura-máter que apresenta incidência estimada entre 1% e 2%. O objetivo deste relato foi descrever um caso de paciente com pneumoencéfalo intraventricular após perfuração acidental de dura-máter usando a técnica da perda da resistência com ar. RELAT...

  9. Stimulation of rat cranial dura mater with potassium chloride causes CGRP release into the cerebrospinal fluid and increases medullary blood flow.

    Science.gov (United States)

    Dux, Mária; Will, Christine; Eberhardt, Mirjam; Fischer, Michael J M; Messlinger, Karl

    2017-02-10

    Primary headaches may be accompanied by increased intracranial blood flow induced by the release of the potent vasodilator calcitonin gene-related peptide (CGRP) from activated meningeal afferents. We aimed to record meningeal and medullary blood flow simultaneously and to localize the sites of CGRP release in rodent preparations in vivo and ex vivo. Blood flow in the exposed rat parietal dura mater and the medulla oblongata was recorded by laser Doppler flowmetry, while the dura was stimulated by topical application of 60mM potassium chloride (KCl). Samples of jugular venous plasma and cerebrospinal fluid (CSF) collected from the cisterna magna were analysed for CGRP concentrations using an enzyme immunoassay. In a hemisected rat skull preparation lined with dura mater the CGRP releasing effect of KCl superfusion was examined. Superfusion of the dura mater with KCl decreased meningeal blood flow unless alpha-adrenoceptors were blocked by phentolamine, whereas the medullary blood flow was increased. The same treatment caused increased CGRP concentrations in jugular plasma and CSF and induced significant CGRP release in the hemisected rat skull preparation. Anaesthesia of the trigeminal ganglion by injection of lidocaine reduced increases in medullary blood flow and CGRP concentration in the CSF upon meningeal KCl application. CGRP release evoked by depolarisation of meningeal afferents is accompanied by increased blood flow in the medulla oblongata but not the dura mater. This discrepancy can be explained by the smooth muscle depolarising effect of KCl and the activation of sympathetic vasoconstrictor mechanisms. The medullary blood flow response is most likely mediated by CGRP released from activated central terminals of trigeminal afferents. Increased blood supply of the medulla oblongata and CGRP release into the CSF may also occur in headaches accompanying vigorous activation of meningeal afferents.

  10. Pulsed estrogen therapy prevents post-OVX porcine dura mater microvascular network weakening via a PDGF-BB-dependent mechanism.

    Directory of Open Access Journals (Sweden)

    Olga V Glinskii

    Full Text Available In postmenopausal women, estrogen (E2 deficiencies are frequently associated with higher risk of intracranial hemorrhage, increased incidence of stroke, cerebral aneurysm, and decline in cognitive abilities. In younger postpartum women and those using oral contraceptives, perturbations in E2 are associated with higher risk of cerebral venous thrombosis. A number of serious intracranial pathologic conditions linked to E2 deficiencies, such as dural sinus thrombosis, dural fistulae, non-parenchymal intracranial hemorrhages, migraines, and spontaneous cerebrospinal fluid leaks, involve the vessels not of the brain itself, but of the outer fibrous membrane of the brain, the dura mater (DM. The pathogenesis of these disorders remains mysterious and how estrogen regulates structural and functional integrity of DM vasculature is largely unknown. Here, we demonstrate that post ovariectomy (OVX DM vascular remodeling is manifested by microvessel destabilization, capillary rarefaction, increased vascular permeability, and aberrant angio-architecture, and is the result of disrupted E2-regulated PDGF-BB signaling within dura microvasculature. These changes, associated with the reduction in systemic PDGF-BB levels, are not corrected by a flat-dose E2 hormone replacement therapy (HRT, but are largely prevented using HRT schedules mimicking physiological E2 fluctuations. We demonstrate that 1 E2 regulates PDGF-BB production by endothelial cells in a dose-dependent manner and 2 optimization of PDGF-BB levels and induction of robust PDGF-mediated endothelial cell-vascular pericyte interactions require high (estrous E2 concentrations. We conclude that high (estrous levels of E2 are important in controlling PDGF-mediated crosstalk between endothelial cells and pericytes, a fundamental mechanism governing microvessel stability and essential for preserving intracranial homeostasis.

  11. Pulsed Estrogen Therapy Prevents Post-OVX Porcine Dura Mater Microvascular Network Weakening via a PDGF-BB-Dependent Mechanism

    Science.gov (United States)

    Glinskii, Olga V.; Huxley, Virginia H.; Glinskii, Vladimir V.; Rubin, Leona J.; Glinsky, Vladislav V.

    2013-01-01

    In postmenopausal women, estrogen (E2) deficiencies are frequently associated with higher risk of intracranial hemorrhage, increased incidence of stroke, cerebral aneurysm, and decline in cognitive abilities. In younger postpartum women and those using oral contraceptives, perturbations in E2 are associated with higher risk of cerebral venous thrombosis. A number of serious intracranial pathologic conditions linked to E2 deficiencies, such as dural sinus thrombosis, dural fistulae, non-parenchymal intracranial hemorrhages, migraines, and spontaneous cerebrospinal fluid leaks, involve the vessels not of the brain itself, but of the outer fibrous membrane of the brain, the dura mater (DM). The pathogenesis of these disorders remains mysterious and how estrogen regulates structural and functional integrity of DM vasculature is largely unknown. Here, we demonstrate that post ovariectomy (OVX) DM vascular remodeling is manifested by microvessel destabilization, capillary rarefaction, increased vascular permeability, and aberrant angio-architecture, and is the result of disrupted E2-regulated PDGF-BB signaling within dura microvasculature. These changes, associated with the reduction in systemic PDGF-BB levels, are not corrected by a flat-dose E2 hormone replacement therapy (HRT), but are largely prevented using HRT schedules mimicking physiological E2 fluctuations. We demonstrate that 1) E2 regulates PDGF-BB production by endothelial cells in a dose-dependent manner and 2) optimization of PDGF-BB levels and induction of robust PDGF-mediated endothelial cell-vascular pericyte interactions require high (estrous) E2 concentrations. We conclude that high (estrous) levels of E2 are important in controlling PDGF-mediated crosstalk between endothelial cells and pericytes, a fundamental mechanism governing microvessel stability and essential for preserving intracranial homeostasis. PMID:24349391

  12. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    Energy Technology Data Exchange (ETDEWEB)

    Filatova, S A; Kamynin, V A; Ryabova, A V; Loshchenov, V B; Tsvetkov, V B; Kurkov, A S [A M Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation); Zelenkov, P V [N. N. Burdenko Scientific Research Neurosurgery Institute, Moscow (Russian Federation); Zolotovskii, I O [Ulyanovsk State University, Ulyanovsk (Russian Federation)

    2015-08-31

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone. (laser applications in medicine)

  13. The Effects of 910-MHz Electromagnetic Field on Rat Cranial Arachnoid and Dura Mater Collagen. The Axial Periodicity of Collagen Fibrils

    Directory of Open Access Journals (Sweden)

    Margaret Tzaphlidou

    2004-01-01

    Full Text Available The axial periodicity of rat arachnoid and dura mater collagen fibrils exposed to 910 MHz for 2 h/day for 30 consecutive days was measured by means of image analysis of electron-optical data. Such measurements were compared with those from sham-exposed animals. These measurements reveal that on exposure, the intermolecular interactions during collagen fibril assembly are affected.

  14. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

    Institute of Scientific and Technical Information of China (English)

    Ho-Sung Lee; Dai-In Kang; Seung Zhoo Yoon; Yeon Hee Ryu; Inhyung Lee; Hoon-Gi Kim; Byung-Cheon Lee; Ki Bog Lee

    2015-01-01

    With chromium-hematoxylin staining, we found evidence for the existence of novel age-depen-dent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-depen-dent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increas-ing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

  15. Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate.

    Science.gov (United States)

    Dong, Zhao; Jiang, Lei; Wang, Xiaohui; Wang, Xiaolin; Yu, Shengyuan

    2011-01-12

    The trigeminovascular nociception induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in anesthetized animals has been widely used as a model for investigation of the pathophysiology of vascular headache such as migraine. However, little is known whether pain behaviors can be induced using this model in conscious animals. Thus, to establish a new model of trigeminovascular nociception in conscious animals and to examine the effects of morphine and rizatriptan benzoate on nociceptive behaviors in this new model, we electrically stimulated the dura mater surrounding the superior sagittal sinus. We found that grooming and head-flick activities were altered partially in a frequency-dependent way and that frequencies ranging from 10 to 20 Hz more easily provoked these behaviors. Moreover, we also demonstrated that these behaviors were reduced by morphine and rizatriptan benzoate. Thus, this new model will provide a useful and appropriate tool to directly assess changes in the intensity of pain for further investigation of pathophysiological mechanisms of migraine in conscious animals.

  16. The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate.

    Science.gov (United States)

    Wang, Xiaolin; Yu, Shengyuan; Dong, Zhao; Jiang, Lei

    2011-01-07

    Fos expression in the brain was systematically investigated by means of immunohistochemical staining after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats. Fos-like immunoreactive neurons are distributed mainly in the upper cervical spinal cord, spinal trigeminal nucleus caudal part, raphe magnus nucleus, periaqueductal gray, ventromedial hypothalamic nucleus, and mediodorsal thalamus nucleus. With the pre-treatment of intraperitoneal injection of rizatriptan benzoate, the number of Fos-like immunoreactive neurons decreased in the spinal trigeminal nucleus caudal part and raphe magnus nucleus, increased in the periaqueductal gray, and remained unchanged in the ventromedial hypothalamic nucleus and mediodorsal thalamus nucleus. These results provide morphological evidence that the nuclei described above are involved in the development and maintenance of the trigeminovascular headache.

  17. 硬脊膜完整性可影响脑脊液中细胞因子的水平☆%Dura mater spinalis integrity may influence cytokine levels in the cerebrospinal fluid

    Institute of Scientific and Technical Information of China (English)

    白万山; 王新伟; 袁文; 王占超; 梁磊; 王会学

    2013-01-01

    BACKGROUND:Pathophysiological mechanisms after spinal cord injury are very complex, so there is no compressive and in-depth understanding on it. OBJECTIVE:To study the effect of dura mater spinalis integrity on cytokine levels in the cerebrospinal fluid of animal models of spinal cord injury. METHODS:The white rabbit models of spinal cord injury were established using clamp compression method, and then the models were randomly divided into four groups:no dura mater spinalis defect group, dura mater spinalis defect group, dura mater spinalis defect composite with membrane repairing group and dura mater spinalis defect composite with autologous fascia repair group. Enzyme-linked immunosorbent assay was performed to detect the changes of levels of cytokines (interleukin-6, interleukin-10 and tumor necrosis factorα) in the cerebrospinal fluid at 30 minutes, 1, 3, 6, 12 and 36 hours after surgery. RESULTS AND CONCLUSION:The levels of interleukin-6, interleukin-10 and tumor necrosis factorαin the cerebrospinal fluid of the dura mater spinalis defect group, dura mater spinalis defect composite with membrane repairing group and dura mater spinalis defect composite with autologous fascia repair group were significantly lower than those of the no dura mater spinalis defect group at 6 hours after surgery (P0.05). The results indicate that maintaining the integrity of dura mater spinalis of the spinal cord injury model can affect the levels of interleukin-6, interleukin-10 and tumor necrosis factorαin the cerebrospinal fluid, thus inhibiting the inflammatory response.%  背景:脊髓损伤后的病理生理机制非常复杂,人们对此认识还很不全面、深入。目的:观察脊髓损伤动物模型中硬脊膜完整性对脑脊液内细胞因子水平的影响。  方法:采用钳夹压迫法建立新西兰大白兔脊髓损伤模型,随机分为无硬脊膜缺损组、硬脊膜缺损组、硬脊膜缺损复合膜修复组、硬脊膜缺损

  18. Efeito da quercetina sobre o extravasamento plasmático no sistema nervoso dura-mater de ratos

    Directory of Open Access Journals (Sweden)

    Luiz Arthur Rangel Cyrino

    2002-01-01

    Full Text Available Estudos recentes têm demonstrado que os bioflavonóides afetam vários sistemas enzimáticos nos mamíferos. A dura-máter é um tecido que recebe inervação peptidérgica. No cérebro, a inflamação neurogênica envolve a liberação da substância P (SP por terminais nervosos sensoriais e é modulada pela endopeptidase neutra (NEP e pela enzima conversora da angiotensina (ECA. Neste estudo, avaliamos o efeito da quercetina, que representa mais de 50% dos bioflavonóides, sobre o extravasamento plasmático induzido pela SP em tecidos selecionados no sistema nervoso central de ratos e dura-máter. Também examinamos o efeito da inibição seletiva das enzimas metabolizadoras da SP (NEP e ECA. A administração de SP (10 nmol/kg e 30 nmol/kg, i.v. aumentou o extravasamento plasmático de maneira dose dependente na duramáter, não apresentando nenhum efeito nos outros tecidos; este efeito foi potencializado por inibidores seletivos da NEP e da ECA. A quercetina (30 mg/kg v.o. aumentou o extravasamento plasmático em relação ao controle em todos os tecidos. O prétratamento com quercetina potenciou significativamente o extravasamento plasmático induzido pela SP (10 nmol/kg na dura-máter. Resultados obtidos com o pré-tratamento com antagonistas específicos para receptores da substância P e bradicinina (NK-1 e B2 sugerem que o aumento do extravasamento plasmático induzido pela quercetina e a potenciação da resposta à SP foram devidos ao acúmulo deste neuropeptídeo na dura-máter.

  19. Effects of variation of chitosan concentration on the characteristics of membrane cellulose bacteria-chitosan biocomposites as candidates for artificial dura mater

    Science.gov (United States)

    Widiyanti, Prihartini; Jabbar, Hajria; Rudyardjo, Djony Izak

    2017-02-01

    This study was conducted to determine the effect of variation in concentration of chitosan on the physical and biological characteristics of the membrane of bacterial cellulose-chitosan biocomposites through immersion precipitation method. Bacterial cellulose membrane was soaked in a solution of chitosan whose concentration variation are 0.1%; 0.3%; 0.5% and 0.7%. The characterization tests which were conducted included the analysis of functional groups (FTIR), tensile strength test, morphology test (SEM), and cytotoxicity assay using MTT Assay method. Based on the cluster analysis test, the results of FTIR spectra indicate changes in the physical bond which means that there is interaction between the bacterial cellulose membrane with chitosan on each sample. The bacteria produced cellulose membrane with tensile strength of 10.53 ± 0.19 MPa while the microbial cellulose membrane by adding 0.5% chitosan concentration had tensile strength value of 8:58 ± 0.19 MPa. It shows that with the addition of chitosan it would decrease the tensile strength in microbial cellulose membrane. This was shown by 496.2 nm - 2,032 µm pore size with a thickness (mm) of 0:35 ± 0.33 to 0.81 ± 0.26. Based on the test results of the analysis of functional groups, tensile strength test, and morphology test, membrane microbial cellulose-chitosan biocomposites have the potential to be used as artificial dura mater candidate.

  20. Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats

    Institute of Scientific and Technical Information of China (English)

    Jiang Lei; Dong Zhao; Li Fengpeng; Liu Ruozhuo; Qiu Enchao; Wang Xiaolin; Yu Shengyuan

    2014-01-01

    Background The molecular and cellular origins of migraine headache are among the most complex problems in contemporary neurology.Up to now the pathogenesis of migraine still remains unclearly defined.The objective of this study was to explore new factors that may be related to the mechanism of migraine.Methods The present study performed a comprehensive analysis of gene expression in the trigeminal nucleus caudalis induced by electrical stimulation of dura mater surrounding the superior sagittal sinus in conscious rats using microarray analysis followed by quantitative real-time reverse-transcribed polymerase chain reaction (qRT-PCR) verification.Student's two sample t-test was employed when two groups were compared.A P value <0.05 was considered to be statistically significant.Results Comparing the placebo and the electrical stimulation groups,40 genes were determined to be significantly differentially expressed.These significantly differentially expressed genes were involved in many pathways,including transporter activity,tryptophan metabolism,G protein signaling,kinase activity,actin binding,signal transducer activity,anion transport,protein folding,enzyme inhibitor activity,coenzyme metabolism,binding,ion transport,cell adhesion,metal ion transport,oxidoreductase activity,mitochondrion function,and others.Most of the genes were involved in more than 2 pathways.Of particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of Kdr.Conclusion These findings may provide important clues for a better understanding of the molecular mechanism of migraine.

  1. Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72).

    Science.gov (United States)

    Lukács, M; Warfvinge, K; Tajti, J; Fülöp, F; Toldi, J; Vécsei, L; Edvinsson, L

    2017-12-01

    Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund's Adjuvant (CFA) onto the dura mater caused activation in rat trigeminal ganglion (TG) which was abolished by a systemic administration of kynurenic acid (KYNA) derivate (SZR72). Here, we hypothesize that this activation may extend to the trigeminal complex in the brainstem and is attenuated by treatment with SZR72. Activation in the trigeminal nucleus caudalis (TNC) and the trigeminal tract (Sp5) was achieved by application of CFA onto the dural parietal surface. SZR72 was given intraperitoneally (i.p.), one dose prior CFA deposition and repeatedly daily for 7 days. Immunohistochemical studies were performed for mapping glutamate, c-fos, PACAP, substance P, IL-6, IL-1β and TNFα in the TNC/Sp5 and other regions of the brainstem and at the C1-C2 regions of the spinal cord. We found that CFA increased c-fos and glutamate immunoreactivity in TNC and C1-C2 neurons. This effect was mitigated by SZR72. PACAP positive fibers were detected in the fasciculus cuneatus and gracilis. Substance P, TNFα, IL-6 and IL-1β immunopositivity were detected in fibers of Sp5 and neither of these molecules showed any change in immunoreactivity following CFA administration. This is the first study demonstrating that dural application of CFA increases the expression of c-fos and glutamate in TNC neurons. Treatment with the KYNA analogue prevented this expression.

  2. 偏头痛大鼠硬脑膜肥大细胞脱颗粒与神经源性炎症相关因子的变化%Changes on degranulation of mast cells and neurogenic inflammation-related factors in the dura mater of the rat model of migraine

    Institute of Scientific and Technical Information of China (English)

    徐武; 史兆春; 韦俊超; 曹月州; 吴婷; 万琪

    2011-01-01

    目的 观察偏头痛大鼠硬脑膜肥大细胞脱颗粒与神经源性炎症相关因子的变化,探讨偏头痛疼痛产生的可能机制.方法 64只SD大鼠随机分为刺激组(32只)和假手术组(32只).电刺激大鼠单侧三叉神经节建立偏头痛模型,放射免疫法测定刺激侧颈静脉血中降钙素基因相关肽(CGRP)的含量.酶联免疫吸附法测定刺激侧颈静脉血中组胺和硬脑膜中前列腺素E2(PGE2)的含量,甲苯胺蓝染色观察硬脑膜肥大细胞的数量及脱颗粒百分率,免疫组织化学染色法、免疫蛋白质印迹技术观察硬脑膜中环氧化酶-2(COX-2)的阳性细胞数及蛋白表达.结果 假手术组和刺激组颈静脉血中CGRP含量分别为(59.20±11.66)pg/ml和(82.84±16.24)pg/ml(t=-3.34);组胺含量分别为(9.87±0.88)ng/ml和(11.59±1.20)ng/ml(t=-3.27);硬脑膜中肥大细胞数量分别为15.46±2.40和11.63±1.67(t=3.71),脱颗粒百分率分别为14.09%±4.53%、29.10%±9.39%(t=-4.07).两组硬脑膜中PGE2的含量分别为(80.70±10.60)pg/ml和(382.30±20.90)pg/ml(t=-16.674);硬脑膜中COX-2阳性细胞数分别为42.00±18.40和139.00±20.50(t=-7.994),COX-2蛋白表达(吸光度值)分别为19.50±9.20和359.20±21.90(t=-5.190).两组间比较,上述指标差异均有统计学意义(P<0.05).结论 电刺激单侧三叉神经节可诱导硬脑膜肥大细胞脱颗粒及神经源性炎症的产生,相关炎症因子的改变可能是偏头痛疼痛发生的重要病理生理基础.%Objective To observe the changes on the neurogenic inflammation-related factors in the dura mater of the rat model of migraine and investigate the possible mechanism of the pain of migraine.Methods SD rats were randomly divided into stimulation group ( n = 32 ) and sham group ( n = 32 ).Unilateral trigeminal ganglion was stimulated to induce migraine for rats in the stimulation group. Rats in the sham group were subjected to sham surgery. The levels of calcitonin gene-related peptide (CGRP) in

  3. 小儿外科手术中行丙泊酚靶控加单次硬膜的效果探究%Effect exploration of implementation of propofol target control plus one-time dura mater in pediatric surgery

    Institute of Scientific and Technical Information of China (English)

    时文俊

    2014-01-01

    Objective To investigate the implementation effect of propofol target control plus one-time dura mater in pediatric surgery. Methods Eighty children who received surgical treatment in our hospital from September 2012 to January 2014 were selected as the study subjects and randomly and evenly divided into the study group and the control group, which received one-time epidural plus propofol target control and ketamine anesthesia respectively. The patients' blood pressure, heart rate, oxyhemoglobin saturation, physical tamper, muscle relaxation and other indicators of the two groups in different time periods were compared. Results In the control group, the blood pressure and heart rates at the beginning of surgery and at the end of surgery increased significantly compared to the blood pressure and heart rate before surgery(P < 0.05), and in the study group, the blood pressure did not change significantly, but it was lower than that of the control group in the corresponding period, with statistically significant difference(P<0.05). In the study group, the heart rates at the beginning of surgery and at the end of surgery reduced significantly compared to the heart rate before surgery(P<0.05) and reduced a lot compared to the heart rate of the control group in the corresponding period(P<0.05). The study group had less physical tamper and shorter awakening time, with statistically significant differences(P < 0.05). Conclusion In pediatric surgery, the implementation of propofol target control plus one-time dura mater does not have large influence on the children's respiratory circulation and has the features of good effect, fast awakening and safety.%目的:探究在小儿外科手术中行丙泊酚靶控加单次硬膜的效果。方法选取2012年9月~2014年1月来本院接受手术治疗的80例患儿作为研究对象,随机等分为研究组和对照组,分别为单次硬膜外加丙泊酚靶控和氯胺酮麻醉,比较不同时间段的两组患者血

  4. Effects of Yunnan Baiyao through inner layer of cerebral dura mater on cerebral perfusion and oxygen metabolism in rabbits with severe traumatic brain injury%硬脑膜夹层导入云南白药对兔重型颅脑创伤后脑灌注和氧代谢的影响

    Institute of Scientific and Technical Information of China (English)

    徐震; 吕晓皑; 尹利明; 竺国充; 张昕; 李徐; 陈祖鹏

    2012-01-01

    Objective: To explore the effects of Yunnan Baiyao through inner layer of cerebral dura mater on cerebral perfusion and oxygen metabolism in rabbits with severe traumatic brain injury. Methods: 40 New Zealand white rabbits were divided into cerebral dura mater Yunnan Baiyao group(A group), intravenous Mannitol group(B group), oral Yunnan Baiyao group (C group) and control group(D group). Record ICP, CPP and MABP. TCD measured cerebral blood flow volume. Monitor blood gas analysis in femora) artery and internal jugular venous bulb, accounting the CEO2 and D-values of glucose and lactic acid between artery and venous bulb. Results: From 12 to 36 hour after therapy: the ICP of A was highter than B, the CPP and CBFV were lower than B (P<0.05). At 48 hour: the ICP of A was highter than B and lower than C and D, the CPP was lower than B and highter than Cand D, while the CBFV of A was highter than C and D(P<0.05). From 60 to 96 hour: the ICP of A was lower than C and D, the CPP of A was highter than C and D, the CBFV of A was highter than B, C and D(P<0.05). From 36 to 96: The Glua-jv and CEO2 of A were highter than B, C and D, while the Lacjv-a was lower than B, C and D(P<0.05). Conclusion: Yunnan Baiyao through cerebral dura mater can reach effective treatment concentration in brain. By increasing the efficiency of oxygen metabolism of brain it can ameliorate brain cell hypoxia and energy metabolism handicap, adjust cerebral microcirculation, thus improves cytotoxic brain edema, decreases cerebral blood flow resistance, reduces ICP and increase the CPP and CBFV.%目的:探讨硬脑膜夹层应用云南白药对兔重型颅脑创伤后颅内压、脑血流量和脑代谢的影响.方法:将40只雄性新西兰大白兔分为硬脑膜夹层云南白药组(A组)、静脉甘露醇组(B组)、口服云南白药组(C组)和空白组(D组),制作重型颅脑创伤模型,行颅内压(ICP)监测,记录平均动脉压(MABP),计算脑灌注压(CPP),经颅多普勒(TCD)测定脑

  5. A dor durante a punção do canal vertebral e sua relação com a inervação do ligamento amarelo, da dura-máter e do ligamento longitudinal posterior El dolor durante la punción del canal vertebral y su relación con la inervación del ligamento amarillo, de la dura-máter y del ligamento longitudinal posterior Pain during spinal canal puncture and its relationship with ligamentum flavum, dura-mater and posterior longitudinal ligament innervation

    Directory of Open Access Journals (Sweden)

    Edmundo Zarzur

    2004-12-01

    influence of general anesthesia and that is why blockade with conscious patients is advisable. Pain is only referred when needle or catheter tip bypass the medium sagital plane to reach the antero-lateral epidural compartment, thus being able to touch nervous rootlets close to intervertebral foramina. Except for studies on skin, subcutaneous tissue and interspinous ligament innervation, this study aimed at reviewing the innervation of some spinal canal structures, namely, ligamentum flavum, posterior longitudinal ligament, dura-mater and intervertebral disk. CONTENTS: Studies on spinal canal innervation are presented in this literature review, aiming at understanding pain during spinal puncture. CONCLUSIONS: Ligamentum flavum is not innervated, thus explaining lack of pain during puncture. Other pains during puncture may be attributed to Luschka's nerve, which innervates posterior longitudinal ligament and dural ventral portion.

  6. Cefaleia pós-punção da dura máter

    OpenAIRE

    Veiga, R; Pinheiro, N; Vilaça, MJ; Morais, S; Carmona, C

    2012-01-01

    Apresenta uma revisão da anatomia, fisiopatologia,clinica, diagnóstico e tratamento das cefaleias pos punção da dura mater. Faz uma revisão da casuistica do serviço de anestesiologia em relação a esta entidade clinica e apresenta alguns casos clinicos de cefaleias para diagnóstico diferencial com as cefaleias pós punção da dura mater.

  7. Cavernous hemangioma of the dura mater mimicking meningioma

    Directory of Open Access Journals (Sweden)

    Hambra Di Vitantonio

    2015-01-01

    Conclusions: Dural-based cavernous hemangiomas of the convexity are uncommon lesions. Up to now, only 13 cases have been described in the literature. The authors have discussed clinical aspects, radiological features, surgical treatment, and operative findings.

  8. Stabat Mater. Chant gregorien / Patric Wiklacz

    Index Scriptorium Estoniae

    Wiklacz, Patric

    1997-01-01

    Uuest heliplaadist "Stabat Mater. Chant gregorien. Palestrina: Stabat Mater a 8; Pärt: Stabat Mater; Browne: Stabat Mater dolorosa a 6. Fretwork (concort de violes)". Virgin Classics 545 272-2 (CD: 167F)

  9. Stabat Mater. Chant gregorien / Patric Wiklacz

    Index Scriptorium Estoniae

    Wiklacz, Patric

    1997-01-01

    Uuest heliplaadist "Stabat Mater. Chant gregorien. Palestrina: Stabat Mater a 8; Pärt: Stabat Mater; Browne: Stabat Mater dolorosa a 6. Fretwork (concort de violes)". Virgin Classics 545 272-2 (CD: 167F)

  10. From Virgil to Alma Mater

    Science.gov (United States)

    Spitz, Ellen Handler

    2007-01-01

    For a college to become an alma mater in the hearts of its students, it must show, true to the Latin meaning, the wisdom and comfort of a good foster mother. Since "alma mater" is Latin, and since the study of Latin has waned on all educational levels in both pious and secular milieus, the author wonders whether folks who use that term really know…

  11. Use of equine pericardium sheet (LYOMESH®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery

    OpenAIRE

    Cavallo, Luigi M.; Solari, Domenico; Somma, Teresa; Di Somma, Alberto; Chiaramonte, Carmela; Cappabianca, Paolo

    2013-01-01

    Objective: The aim of this study was to describe the use of equine pericardium sheet (Lyomesh®) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary adenomas. Methods: We reviewed data of patients that underwent surgery by means of an endoscopic endonasal transsphenoidal approach for the removal of pituitary adenomas over a 12-months period, starting in May 2012, i.e. when we adopted Lyomesh® (Audio Technologies, Pia...

  12. Human mammaglobin transcript amplification for differential diagnosis in a breast cancer metastatic to dura mater.

    Science.gov (United States)

    Dono, Mariella; Ferro, Paola; Franceschini, Maria Cristiana; Dessanti, Paolo; Bacigalupo, Bartolomeo; Cibei, Eugenio; Capellini, Cesare; Amoroso, Domenico; Camerini, Andrea; Fedeli, Franco; Roncella, Silvio

    2011-03-01

    In breast cancer (BC), metastases to the central nervous system usually arise in women with advanced disease. Diagnosis of leptomeningeal (LM) metastasis is based on neurological symptoms, imaging studies and cytological detection of malignant cells in the cerebrospinal fluid (CSF). However, often these approaches are not sensitive enough to recognize leptomeninges involvement and subsequently to make a diagnosis of LM carcinomatosis. This study investigated the employment of reverse transcriptase-polymerase chain reaction (RT-PCR) for the human mammaglobin (hMAM) gene in a case of BC with cerebral metastases in which the involvement of the leptomeninges was in doubt. Amplification of hMAM mRNA was performed from CSF cells by RT-PCR. No amplification of hMAM was obtained from the CSF cells. RT-PCR for human mammaglobin mRNA of the CSF in BC patients with brain metastases may aid clinical determination of LM involvement and consequently the choice of the most effective therapy regimens for affected patients.

  13. Radiologic study on lamina dura

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Hyung Kyu [Dept. of Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1981-11-15

    This study was performed to investigate the thickness of lamina dura of the human teeth in periodontal disease, which obtained from the intraoral roentgenograms of the 122 cases taken by bisecting technic. All films were divided into the different ages, the different sexes, and the different location of the different teeth. The obtained results were as follows: 1. Compared with the normal teeth, the thickness of lamina dura in periodontal disease is increased in all of different ages, sexes and teeth. 2. Generally, the alveolar crest portion is the thickest among the root surfaces, and midroot, apex followed, and the average thickness of the posterior teeth is thicker than that of anterior teeth. 3. The mean value of the whole maxillary teeth is almost same as that of mandibular teeth. 4. On the whole cases, the differences of male and female is about 0.01 mm, which is not a significant differences.

  14. Therapy dura mater spinalis abscess research progress%硬脊膜外脓肿的研究进展

    Institute of Scientific and Technical Information of China (English)

    付霜; 倪家骧

    2010-01-01

    脊髓硬脊膜外脓肿(spinal epidural abscess,SEA)是神经外科少见的急症之一,临床误诊率及致残率均较高.本文详细评估和分析了自1985年以来发表的关于SEA的文献,尤其是患者因椎管内麻醉发展而来的病例分析.从流行病学,发病机理和高危因素,临床表现和实验室检查,诊断以及治疗等方面简单概括SEA的特点.

  15. "Mater puerorum'. A medieval naming for an enigmatic children's disease.

    Science.gov (United States)

    Kottek, S S

    1981-09-01

    The pediatric clinical entity called "Mater Puerorum' appears first in the latin translation of Rhazes' "Practica Puerorum' and in his "Continens'. His descriptions of the disease could give some likeness either to a diagnosis of night terrors, or of hyperpyretic convulsions, or of a slight form of epilepsy. Mater Puerorum is afterwards described by most pediatric authors till the Renaissance period without much originality. Rhazes being one of their main sources anyway. Mater Puerorum has been considered by Still and Radbill as a synonym for hysterical fits in children. Going back to the Arabic original naming: Ummu's Sibyan, we venture another etymology based on Babylonian-Judeo-Arabic demonology. The "Mother of the Children' could be the female demon Karina--or Lilith--which is said to come to plague the children at night. The naming Mater Puerorum could thus be ascribed to a folklore origin, rather than to hysteria.

  16. Marguerite Duras ja tema võimukolmnurgad / Kärt Hellerma

    Index Scriptorium Estoniae

    Hellerma, Kärt, 1956-

    2007-01-01

    Arvustus: Duras, Marguerite. Armuke / tlk. Malle Talvet. Tallinn : Perioodika, 1989. (Loomingu Raamatukogu ; 1989, 11-12) ; Duras, Marguerite. Tamm Vaikse ookeani vastu / tlk. Triinu Tamm. Tallinn : Varrak, 2006

  17. Marguerite Duras ja tema võimukolmnurgad / Kärt Hellerma

    Index Scriptorium Estoniae

    Hellerma, Kärt, 1956-

    2007-01-01

    Arvustus: Duras, Marguerite. Armuke / tlk. Malle Talvet. Tallinn : Perioodika, 1989. (Loomingu Raamatukogu ; 1989, 11-12) ; Duras, Marguerite. Tamm Vaikse ookeani vastu / tlk. Triinu Tamm. Tallinn : Varrak, 2006

  18. Complete Genome Sequence of Bacillus megaterium Myophage Mater

    OpenAIRE

    Lancaster, Jacob C.; Hodde, Mary K.; Hernandez, Adriana C.; Kuty Everett, Gabriel F.

    2015-01-01

    Bacillus megaterium is a ubiquitous, soil inhabiting Gram-positive bacterium that is a common model organism and is used in industrial applications for protein production. The following reports the complete sequencing and annotation of the genome of B. megaterium myophage Mater and describes the major features identified.

  19. The Labour Market Effects of "Alma Mater": Evidence from Italy

    Science.gov (United States)

    Brunello, Giorgio; Cappellari, Lorenzo

    2008-01-01

    We use data from a nationally representative survey of Italian graduates to study whether "Alma Mater" matters for employment and earnings 3 years after graduation. We find that the attended college matters, and that there are important college-related differences, both among and within regions of the country. These differences, however,…

  20. Variability and performance evaluation of introgressed Nigerian dura x Deli dura oil palm progenies.

    Science.gov (United States)

    Noh, A; Rafii, M Y; Mohd Din, A; Kushairi, A; Norziha, A; Rajanaidu, N; Latif, M A; Malek, M A

    2014-04-03

    Twelve introgressed oil palm (Elaeis guineensis) progenies of Nigerian dura x Deli dura were evaluated for bunch yield, yield attributes, bunch quality components and vegetative characters at the Malaysian Palm Oil Board Research Station, in Keratong, Pahang, Malaysia. Analysis of variance revealed significant to highly significant genotypic differences, indicating sufficient genetic variability among the progenies for bunch yield and its attributes, vegetative characters and bunch quality components, except fruit to bunch ratio. Fresh fruit bunch yield ranged from 167 kg·palm(-1)·year(-1) in PK1330 to 212 kg·palm(-1)·year(-1) in PK1351, with a mean yield of 192 kg·palm(-1)·year(-1). Among the progeny, PK1313 had the highest oil to bunch ratio (19.36%), due to its high mesocarp to fruit ratio, fruit to bunch ratio and low shell to fruit ratio. Among the progenies, PK1313 produced the highest oil yield of 31.4 kg·palm(-1)·year(-1), due to a high mesocarp to fruit ratio (61.2%) and a low shell to fruit ratio (30.7%), coupled with high fruit to bunch ratio (65.6%). PK1330 was found promising for selection, as it had desirable vegetative characters, including smaller petiole cross section (27.15 cm2), short rachis length (4.83 m), short palm height (1.85 m), and the lowest leaf number (164.6), as these vegetative characters are prerequisites for selecting palms for high density planting and high yield per hectare. The genetic variability among the progenies was found to be high, indicating ample scope for further breeding, followed by selection.

  1. Potential role for MATER in cytoplasmic lattice formation in murine oocytes.

    Directory of Open Access Journals (Sweden)

    Boram Kim

    Full Text Available BACKGROUND: Mater and Padi6 are maternal effect genes that are first expressed during oocyte growth and are required for embryonic development beyond the two-cell stage in the mouse. We have recently found that PADI6 localizes to, and is required for the formation of, abundant fibrillar Triton X-100 (Triton insoluble structures termed the oocyte cytoplasmic lattices (CPLs. Given their similar expression profiles and mutant mouse phenotypes, we have been testing the hypothesis that MATER also plays a role in CPL formation and/or function. METHODOLOGY/FINDINGS: Herein, we show that PADI6 and MATER co-localize throughout the oocyte cytoplasm following Triton extraction, suggesting that MATER co-localizes with PADI6 at the CPLs. Additionally, the solubility of PADI6 was dramatically increased in Mater(tm/tm oocytes following Triton extraction, suggesting that MATER is involved in CPL nucleation. This prediction is supported by transmission electron microscopic analysis of Mater(+/+ and Mater(tm/tm germinal vesicle stage oocytes which illustrated that volume fraction of CPLs was reduced by 90% in Mater(tm/tm oocytes compared to Mater(+/+ oocytes. CONCLUSIONS: Taken together, these results suggest that, similar to PADI6, MATER is also required for CPL formation. Given that PADI6 and MATER are essential for female fertility, these results not only strengthen the hypothesis that the lattices play a critical role in mediating events during the oocyte-to-embryo transition but also increase our understanding of the molecular nature of the CPLs.

  2. ON LOVE AND MELANCHOLIA IN MARGUERITE DURAS'S AUTOFICTION.

    Science.gov (United States)

    Simoglou, Vassiliki N

    2015-07-01

    In the Durassian melancholic atmosphere, past and present, fantasy and reality come together as one. This paper addresses the themes of love and destruction in Marguerite Duras's life that pervade her oeuvre, allowing us to discern a melancholic structure within her autofiction. Writing down her melancholia--the impossible mourning of a loved object--Duras captures nothingness and loss--in order not to die of love. In a constant exchange with her readers, she searches for herself and delivers herself to her readers. This renewable creative process of writing enables her to engage in an ongoing experience of identity reconstruction, in a way similar to the patient in psychoanalysis re-creating his/her life's fiction.

  3. Fibrin Sealants in Dura Sealing: A Systematic Literature Review.

    Directory of Open Access Journals (Sweden)

    Felice Esposito

    Full Text Available Fibrin sealants are widely used in neurosurgery to seal the suture line, provide watertight closure, and prevent cerebrospinal fluid leaks. The aim of this systematic review is to summarize the current efficacy and safety literature of fibrin sealants in dura sealing and the prevention/treatment of cerebrospinal fluid leaks.A comprehensive electronic literature search was run in the following databases: Cochrane Database of Systematic Reviews, Cochrane Central Resister of Controlled Trials, clinicaltrials.gov, MEDLINE/PubMed, and EMBASE. Titles and abstracts of potential articles of interest were reviewed independently by 3 of the authors.A total of 1006 database records and additional records were identified. After screening for duplicates and relevance, a total of 78 articles were assessed by the investigators for eligibility. Thirty-eight were excluded and the full-text of 40 articles were included in the qualitative synthesis. Seven of these included only safety data and were included in the safety assessment. The remaining 33 articles included findings from 32 studies that enrolled a total of 2935 patients who were exposed to fibrin sealant. Among these 33 studies there were only 3 randomized controlled trials, with the remaining being prospective cohort analysis, case controlled studies, prospective or retrospective case series. One randomized controlled trial, with 89 patients exposed to fibrin sealant, found a greater rate of intraoperative watertight dura closure in the fibrin sealant group than the control group (92.1% versus 38.0%, p0.05. Other clinical trials evaluated the effect of fibrin sealant in the postoperative prevention of cerebrospinal fluid leaks. These were generally lower level evidence studies (ie, not prospective, randomized, controlled trials that were not designed or powered to demonstrate a significant advantage to fibrin sealant use. Two small case series studies evaluated the effect of fibrin sealants in

  4. Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice.

    Science.gov (United States)

    Lu, Yong-qing; He, Xie-chao; Zheng, Ping

    2016-04-01

    What factors in mouse oocytes are involved in the ageing-related decline in oocyte quality? The maternal effect gene Mater is involved in ageing-related oocyte quality decline in mice. Premature loss of centromere cohesion is a hallmark of ageing-related oocyte quality decline; the maternal effect gene Mater (maternal antigen that embryos require, also known as Nlrp5) is required for preimplantation embryo development beyond the 2-cell stage, and mRNA expression of Mater decreases with maternal ageing. Mater protein expression level in mature oocytes from 7 young (5-8 weeks old) to 7 old mice (41-68 weeks old) was compared by immunoblotting analysis. Wild-type and Mater-null mice were used to examine whether Mater is necessary for maintaining normal centromere cohesion by means of cytogenetic karyotyping, time-lapse confocal microscopy and immunofluorescence staining. Mater protein is decreased in mature oocytes from old versus young mice (P = 0.0022). Depletion of Mater from oocytes leads to a reduction in centromere cohesion, manifested by precocious sister chromatid separation, enlargement of sister centromere distance and misalignment of chromosomes in the metaphase plate during meiosis I and II. This study was conducted in mice. Whether or not the results are applicable to human remains further elucidation. In addition, we were unable to confirm if the strain of mice (C57BL/6XSv129) at the age of 41-68 weeks old has the 'cohesin-loss' phenotype. Investigating Mater's functional mechanisms could provide fresh insights into understanding how the ageing-related oocyte quality decline occurs. N/A. This work was supported by the research grant from Chinese NSFC to P.Z. (31071274). We have no conflict of interests to declare. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Mechanical and thermal properties of bacterial-cellulose-fibre-reinforced Mater-Bi® bionanocomposite

    Directory of Open Access Journals (Sweden)

    Hamonangan Nainggolan

    2013-05-01

    Full Text Available The effects of the addition of fibres of bacterial cellulose (FBC to commercial starch of Mater-Bi® have been investigated. FBC produced by cultivating Acetobacter xylinum for 21 days in glucose-based medium were purified by sodium hydroxide 2.5 wt % and sodium hypochlorite 2.5 wt % overnight, consecutively. To obtain water-free BC nanofibres, the pellicles were freeze dried at a pressure of 130 mbar at a cooling rate of 10 °C min−1. Both Mater-Bi and FBC were blended by using a mini twin-screw extruder at 160 °C for 10 min at a rotor speed of 50 rpm. Tensile tests were performed according to ASTM D638 to measure the Young’s modulus, tensile strength and elongation at break. A field emission scanning electron microscope was used to observe the morphology at an accelerating voltage of 10 kV. The crystallinity (Tc and melting temperature (Tm were measured by DSC. Results showed a significant improvement in mechanical and thermal properties in accordance with the addition of FBC into Mater-Bi. FBC is easily incorporated in Mater-Bi matrix and produces homogeneous Mater-Bi/FBC composite. The crystallinity of the Mater-Bi/FBC composites decrease in relation to the increase in the volume fraction of FBC.

  6. DURA PONKSİYONU SONRASI BAŞ AĞRISI

    OpenAIRE

    Tapar, Hakan; Kaya, Ziya; SÜREN, Mustafa

    2013-01-01

    Dura ponksiyonuna bağlı görülen ve hastanın yaşam konforunu etkileyen baş ağrısı birçok nedene bağlı olarak görülebilmektedir. Anestezistin deneyimi, kullanılan iğnenin özellikleri, hastanın yaş ve cinsiyeti en yaygın nedenler arasında sayılabilir. Baş ağrısının fizyopatalojisi ve özellikle tedavisi ile ilgili değişik yaklaşımlar vardır. Bu derlemede literatürler ışığında , spinal anestezi sonrası baş ağrısını sunmayı amaçladık.

  7. A Defining Time for Physical Education Futures? Exploring the Legacy of Fritz Duras

    Science.gov (United States)

    Kirk, David

    2014-01-01

    This paper explores the legacy of Dr Fritz Duras in order to address the issue of whether the implementation of a new curriculum for health and physical education in Australia represents a defining time for the subject. Dr Duras was Director of the first physical education teacher education course at the University of Melbourne during an earlier…

  8. Contribuição ao estudo anatômico da dura-máter do Bradypus torquatus (Linnaeus, 1758 e Bradypus variegatus (Schinz, 1825

    Directory of Open Access Journals (Sweden)

    Jussara Rocha Ferreira

    2005-10-01

    Full Text Available Neurosciences research have contribution to elucidate the history of the animal on the earth, nevertheless many sylvan animals, in South America yet won't be studied. The Sloth's, in risk of extinction, because your high specificity and alimentary specialization can give us information about evolutive animal history. We use dead animals by natural process, freeze, fixed and injected by natural latex in Matinha´s reserve, Itabuna/Ilhéus, ceded for projects in association between the reserve, São Paulo University and other institutions. The dissections were realized by magnified glass succors, documented, descript and analyzed by the references. We don't have many references about the theme thus were utilized descriptions and systematizations in humans and other mammals as the base for discussions. In the dura-mater was found a similar structure in other mammals, with falx´s brain and cerebelar tent , over there venous sinus. This sinus show interests alterations in your formations, all adequate to your anatomic characteristics of your brain, among these a orbiculo-frontal sinus around the base of olfactory bulbs, a sinus para-sagital cerebelar in a place of a cerebelar vein like description for many authors, and a connection between transverse sinus and inter-transverse sinus. Finally a peculiarity in this system is a transposition of the sigmoid sinus in a caudo-rostral orientation draining the blood support of the rostral region of the brain, specially the olfactory set.

  9. To the Editor: comment on Eremets and Troyan, Nature Mater. 10, 927-931 (2011)

    OpenAIRE

    Goncharov, Alexander F.; Struzhkin, Viktor V.

    2012-01-01

    Eremets and Troyan (Nature Mater. 10, 927-931 (2011)) claim that they produced the conducting liquid hydrogen state at 270 GPa and 295 K. Their evidence consists of disappearance of Raman signals, visual observations, and measurements of electrical conductivity in diamond anvil cells (DAC). However, there is no proof that the reported observations are due to transformations in hydrogen.

  10. Interaction of ionizing radiation with mater; Oddzialywanie promieniowania jonizujacego z materia

    Energy Technology Data Exchange (ETDEWEB)

    Pogocki, D. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1997-10-01

    The early radiation effects (e.g. excitation, ionization) have been described and compared for different kind of radiation interacting with mater. The mechanism of energy deposition in connection with radiation dose and their spatial distribution has been shown.The commonly used definitions and units in radiation dosimetry have been also reviewed. 4 refs, 4 figs.

  11. Application of collagen sponge artificial dura without suturing to big bone flap decompression after traumatic brain injury%免缝胶原海绵人工硬脑膜在颅脑损伤大骨瓣减压术中的应用

    Institute of Scientific and Technical Information of China (English)

    罗心凯; 陈治标; 陈谦学

    2016-01-01

    Objective To explore the value of application of the collagen sponge artificial dura without suturing to big bone flap decompression after severe traumatic brain injury (TBI). Methods The clinical data of 108 patients with severe TBI who underwent big bone flap decompression were analyzed retrospectiely. Of these 108 patients, 54 received the repair of dura mater with collagen sponge artificial idura without suturing in the observed group and 54 with the routine artificial dura in the control group. The operating time for dural repair, rate of postoperative complications, time interval from hematoma clearance to cranioplasty, operative time for cranioplasty, intraoperative blood loss volume, rate of dural damage and GOS scores 6 months after the operation were analyzed in the two groups. Results There were insignificant differences in the rate of postoperative complications (1.85%vs 7.41%) and GOS score 6 months after the operation between both the groups (P>0.05). There were significant differences in the operating time for dura repair [those in the observed and control group were (5.23 ± 1.25) min and (12.58 ± 2.65) min respectively], time interval from hematoma clearance to cranioplasty [those in the observed and control groups were (115.78 ± 21.56) days and (217.64 ± 34.32) days respectively], operative time for cranioplast [those in the observed and control groups were (73.25 ± 7.62) min and (98.63 ± 11.58) min respectively], intraoperative blood loss volume [those in the observed and control groups were (66.45±18.52) ml and (101.34±21.78) ml respectively], rate of damage to dura mater [those in the observed and control groups were 4% and 14.29% respectively) between both the groups (P0.05)。观察组修补硬脑膜至颅骨修补术时间间隔、修补术时间、修补术中出血量、脑膜破裂率均明显低于对照组(P<0.05)。结论免缝胶原海绵人工硬脑膜在颅脑损伤中能够发挥减压作用,保护脑功能,手术

  12. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

    Directory of Open Access Journals (Sweden)

    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  13. Discovery of the mineral brucite (magnesium hydroxide) in the tropical calcifying alga Polystrata dura (Peyssonneliales, Rhodophyta).

    Science.gov (United States)

    Nash, Merinda C; Russell, Bayden D; Dixon, Kyatt R; Liu, Minglu; Xu, Huifang

    2015-06-01

    Red algae of the family Peyssonneliaceae typically form thin crusts impregnated with aragonite. Here, we report the first discovery of brucite in a thick red algal crust (~1 cm) formed by the peyssonnelioid species Polystrata dura from Papua New Guinea. Cells of P. dura were found to be infilled by the magnesium-rich mineral brucite [Mg(OH)2 ]; minor amounts of magnesite and calcite were also detected. We propose that cell infill may be associated with the development of thick (> ~5 mm) calcified red algal crusts, integral components of tropical biotic reefs. If brucite infill within the P. dura crust enhances resistance to dissolution similarly to crustose coralline algae that infill with dolomite, then these crusts would be more resilient to future ocean acidification than crusts without infill. © 2015 Phycological Society of America.

  14. Secondary Waste Form Down-Selection Data Package—DuraLith

    Energy Technology Data Exchange (ETDEWEB)

    Mattigod, Shas V.; Westsik, Joseph H.

    2011-09-15

    This data package developed for the DuraLith wasteform includes information available in the open literature and from data obtained from testing currently underway. DuraLith is an alkali-activated geopolymer waste form developed by the Vitreous State Laboratory at The Catholic University of America (VSL-CUA) for encapsulating liquid radioactive waste. A DuraLith waste form developed for treating Hanford secondary waste liquids is prepared by alkali-activation of a mixture of ground blast furnace slag and metakaolinite with sand used as a filler material. Based on optimization tests, solid waste loading of {approx}7.5% and {approx}14.7 % has been achieved using the Hanford secondary waste S1 and S4 simulants, respectively. The Na loading in both cases is equivalent to {approx}6 M. Some of the critical parameters for the DuraLith process include, hydrogen generation and heat evolution during activator solution preparation using the waste simulant, heat evolution during and after mixing the activator solution with the dry ingredients, and a working window of {approx}20 minutes to complete the pouring of the DuraLith mixture into molds. Results of the most recent testing indicated that the working window can be extended to {approx}30 minutes if 75 wt% of the binder components, namely, blast furnace slag and metakaolin are replaced by Class F fly ash. A preliminary DuraLith process flow sheet developed by VSL-CUA for processing Hanford secondary waste indicated that 10 to 22 waste monoliths (each 48 ft3 in volume) can be produced per day. There are no current pilot-scale or full-scale DuraLith plants under construction or in operation; therefore, the cost of DuraLith production is unknown. The results of the non-regulatory leach tests, EPA Draft 1313 and 1316, Waste Simulant S1-optimized DuraLith specimens indicated that the concentrations of RCRA metals (Ag, Cd, Cr, Hg, and Pb) in the leachates were well below the Universal Treatment Standard limits in 40 CFR 268

  15. From Dr Fritz Duras to the "Obesity Crisis": Observations the Evolution of Human Movement Studies as an Academic Field

    Science.gov (United States)

    Tinning, Richard

    2008-01-01

    Dr Fritz Duras was the first director of a department of physical education in an Australian university. He had a significant influence on the development of the field of physical education in Australia and his legacy is honoured at each biennial ACHPER conference with the Fritz Duras memorial lecture. Recently, the Graduate School of Education at…

  16. Formulación de cápsulas duras de Tamarindus indica L.

    Directory of Open Access Journals (Sweden)

    Jesús Rafael Rodríguez Amado

    Full Text Available Objetivo: formular cápsulas duras a partir de extracto blando de Tamarindus indica L. Métodos: se seleccionaron las cantidades de los excipientes lactosa monohidratada, almidón de maíz y dióxido de silicio coloidal (Aerosil®, utilizando un diseño factorial 2³. Se seleccionó para envasar en cápsulas, el granulado con mejor fluidez y menor humedad residual. Se evaluó la calidad de las cápsulas duras. Resultados: la formulación escogida fue lactosa monohidratada 35,0 g, Aerosil® 3,0 g y almidón de maíz 7,5 g, pues mostró buena fluidez y una humedad residual de 4,17 %. Las cápsulas duras formuladas, presentaron buena calidad tecnológica. Conclusiones: se obtuvieron cápsulas duras que pueden ser preparadas, a pequeña escala, a nivel dispensarial.

  17. « Duras-Godard », conversation télévisuelle

    Directory of Open Access Journals (Sweden)

    Marie-Laure Rossi

    2014-07-01

    Full Text Available Bien que l’esthétique conversationnelle subisse une profonde remise en cause dans la création littéraire du XXe siècle, son héritage est encore perceptible dans le cadre d’un genre inventé grâce au développement de la médiatisation, l’entretien littéraire. L’émission télévisée « Duras-Godard », diffusée en 1987, donne à comprendre comment la mémoire des salons mondains hante encore la réception par le public moderne. Mais elle montre aussi l’art de Marguerite Duras pour faire siennes les normes de cette pratique sociale et en tirer des effets esthétiques propres à enrichir son œuvre publiée. Although the French aesthetic in the art of conversation has been called into question in 20th century literary creation, its heritage is still perceptible within the context of a genre invented by the expansion of mediatization: the literary interview. The television programme “Duras-Godard”, broadcast in 1987, reveals how the memory of social and literary salons still haunts the reception by a modern public. But it also shows how Marguerite Duras manages to appropriate the rules of this social practice to produce specific aesthetic effects in her published work.

  18. A newborn with a large mass: vacuum extraction‐caused dura lesion

    OpenAIRE

    2015-01-01

    Key Clinical Message We report on a newborn with a large, high parieto‐frontally located mass after vacuum extraction. Imaging methods revealed a large subcutaneous collection of cerebrospinal fluid and hemorrhage. Traumatic dura lesions should be considered in neonates presenting with a large head lump after assisted delivery with vacuum extraction.

  19. DuraNode: wireless-networked sensing system for structural safety monitoring

    Science.gov (United States)

    Chung, H.; Park, C.; Xie, Q.; Chou, P.; Shinozuka, M.

    2005-05-01

    DuraNode is a sensing system designed for structural monitoring. It can detect the damage of structural members, provide crucial intelligence information of structural integrity and activate emergency response mechanism in the initial stages of a disaster. The sensor encompasses three MEMS-type accelerometers (SD-1221) and Wi-Fi (802.11b) communication adapter. It operates on solar power and rechargeable battery making it last for long term service without battery replacement. DuraNodes can be deployed in the form of a dense wireless network to enable seamless acquisition of structural intelligence in a complex structural system. A preliminary data acquisition and signal display module with graphic user interface (GUI) has been developed for connection of access points in ad-hoc networking. To validate the performance of DuraNode in structural monitoring applications, experiments were conducted on measuring vibration of a Pedestrian bridge in UC, Irvine, and a two-column bridge bent specimen with a Shake-table test in University of Neveda, Reno. Results were compared with that from conventional wired sensors and showed that DuraNode is cost-effective for carrying out robust sensing functions in the structural safety monitoring missions.

  20. VARSTVO DELAVK MATER V LUČI NOVEJŠE SODNE PRAKSE EU

    OpenAIRE

    2011-01-01

    Uskladiti poklicno in družinsko življenje je velik izziv za delavke matere, sploh v današnjem času, ko sta v večini primerov zaposlena tako oče kot mati. Cilj na področju delovnega prava je zato zagotavljati delavkam materam posebno varstvo. S tem je mišljeno predvsem varstvo pred prekinitvijo poklicne poti zaradi materinstva. Veliko žensk se zanj namreč ne odloča ravno z razlogom bojazni pred odpovedjo pogodbe o zaposlitvi s strani delodajalca ter kolebanjem med materinstvom in kariero. Dipl...

  1. Antecedents to and outcomes of Rh(D) isoimmunization: Mater Mothers Hospital, Brisbane, 1988-1995.

    Science.gov (United States)

    Portmann, C; Ludlow, J; Joyce, A; Chan, F Y

    1997-02-01

    We analyzed the antecedents and outcomes of Rh(D) isoimmunization in a local population. Forty-two Rh(D) isoimmunized women attending Mater Mothers Hospital for antenatal care were identified through the Mater Hospital Blood Bank database; their records were reviewed for variables including sensitizing events, obstetric interventions and pregnancy outcomes. In this group, 74% of women became sensitized despite receiving anti-D immune globulin, 17% did not receive anti-D appropriately and the other failed to attend for treatment of bleeding in pregnancy. Antenatal sensitization was implicated in 6 women (14%) and potentially responsible for isoimmunization in another 18. Over half of the 80 viable pregnancies in this study group required some form of obstetric intervention. Thirty pregnancies required amniocentesis and 1 in 3 babies underwent either intrauterine or exchange transfusion. Three fetal deaths occurred as a result of severe disease. This study offers information highlighting circumstances in which immunoprophylaxis guidelines have failed to impart protection against Rh(D) sensitization and the consequences of such failures.

  2. THE EFFECTS OF NF-KB ON ICAM-1 PROTEIN EXPRESSIONS OF RAT DURA MATER WITH MIGRAINE%NF-κB上调偏头痛大鼠脑膜ICAM-1蛋白表达

    Institute of Scientific and Technical Information of China (English)

    何秋; 王怀良; 章新华; 陈磊

    2007-01-01

    目的:探讨核转录因子-κB(nuclear factor-kappa B,NF-κB)在偏头痛脑膜炎症反应中的作用及细胞间黏附分子-1(intercellular adhesion molecules-1,ICAM-1)表达的调控机制.方法采用静脉注射(iv)硝酸甘油(glyceryl trinitrate,GTN)法建立大鼠偏头痛模型,分为对照组、模型组、溶剂对照组、吡咯烷二硫氨基甲酸(pyrrolidine dithiocarbamate,PDTC)组.各组分别包括0.9%生理盐水或GTN iv后1.5,4h两个实验小组.应用Western印迹法分别观察PDTC对GTN iv后1.5h大鼠脑膜NF-κB蛋白表达水平与GTN iv后4h ICAM-1蛋白表达水平的影响.结果:PDTC 50,100,200 mg.kg-1各剂量组GTN iv后1.5h大鼠脑膜NF-κB蛋白表达量较模型组分别降低30%(P<0.05)、52%(P<0.01)和65%(P<0.01),呈剂量依赖性;PDTC 50,100,200 mg.kg-1各剂量组GTN iv后4h大鼠脑膜ICAM-1蛋白表达量较模型组分别降低36%(P<0.05)、71%(P<0.01)和51%(P<0.01),无剂量依赖关系.结论:NF-κB参与偏头痛时脑膜ICAM-1的蛋白合成调控,在偏头痛的脑膜炎症机制中起着重要作用.

  3. The Application of Artificial Dura Mater to Hemicraniectomy in Patients with Severe Traumatic Brain Injury%人工硬脑膜在去大骨瓣减压术治疗重症颅脑损伤中的应用

    Institute of Scientific and Technical Information of China (English)

    刘涛; 白朝鲁; 梅小波

    2013-01-01

    Objective:To explore the application of large trauma and artificial dural in traumatic brain injury surgery.Method:43 patients with artificial dural in traumatic brain injury surgery were analysed retrospectively,from January 2010 to June 2013.Result:1 patient died of acute high intracranial pressure, more than 42 cases of survival.Evaluation of 1 to six months after GOS:7 cases(16.2%) were cured,mild disability in 12 cases(27.9%),moderate disability in 15 cases(34.8%),severe disability in 5 cases(11.6%),3 cases(7%) of vegetative state,1 case(2.3%) was death.The 40 survivors were followed up,no obvious adverse reaction.Conclusion:Artificial dural repairingcom is safe and effective in large trauma brain injury surgery,It is worthy of clinical application.%目的:探讨大骨瓣结合人工硬脑膜修补术治疗重症颅脑损伤的临床效果。方法:回顾性分析本院自2010年1月-2013年6月收治的43例重症颅脑损伤患者的临床资料,总结手术经验,应用GOS预后评估法对患者术后1个月至半年效果进行评价。结果:1例患者因急性高颅压而死亡,余42例存活。术后1个月至半年内GOS评估:痊愈7例(16.2%),轻残12例(27.9%),中残15例(34.8%),重残5例(11.6%),植物状态3例(7.0%),死亡1例(2.3%)。其中40例存活者得到长期随访,无明显不良反应。结论:大骨瓣减压结合人工硬脑膜修补术治疗重症颅脑损伤疗效可靠,值得临床推广应用。

  4. MATER - Pianeta Terra-Mare: an interactive and multidisciplinary approach to Geosphere sciences

    Science.gov (United States)

    Piangiamore, Giovanna Lucia; Fanelli, Emanuela; Furia, Stefania; Garau, Daniela; Merlino, Silvia; Musacchio, Gemma; Carla Centineo, Maria

    2016-04-01

    Recent studies demonstrate that Earth and Marine Sciences are not properly treated in scholastic programs and in textbooks are included in a superficial way. These topics are interdisciplinary and experimental (biology, ecology, oceanography and geology) and the recent advance in these fields is strictly linked to technologic improvement. School cannot keep up with the huge advances of knowledge experimented in the last 20 years, also for the lack of didactic laboratories sufficiently updated to support experimental activities. In this context, in 2014-15 three Italian Research Institutes (INGV, ISMAR-CNR and ENEA-CRAM) have decided to support the Unified School District "ISA 10"of Lerici (Liguria, Italy) - comprehensive of kindergartner, primary and middle schools - to develop the project MATER - Pianeta Terra-Mare (Planet Earth and Sea). The acronym MATER (MARe and TERra) has also a gender value, as people involved in the projects were women, mostly researchers and teachers, which have worked side by side with other women belonging to environmental and cultural associations of the territory. This heterogeneous group has a common objective: to promote the diffusion of a scientific culture and to sensitize students from 3 to 14 years towards problems occurring in marine and terrestrial environments, fostering the settlement of a sustainable attitude to the exploitation of natural resources and consciousness to natural hazards, such as earthquakes and floods, quite common in the Ligurian region. MATER has been considered as one of the best projects funded by MIUR (Italian Ministry of Education, University and Research) inside the Dissemination of Scientific and Technological Culture call for the year 2014. Natural hazards (Planet Earth) and the chemical-physical aspects and resources of the marine environment (Planet Sea) were the two modules of the project. Planet Earth developed through Piovono Idee! (Cloudy with a chance of Ideas!), an interactive exhibition on

  5. Duração de Macaulay: fórmulas simplificadas de cálculo

    OpenAIRE

    Ferreira, João da Silva

    1995-01-01

    Deduz-se uma nova fórmula simplificada para o cálculo da duração de Macaulay. Mostra-se que esta fórmula permite uma compreensão intuitiva de vários teoremas sobre a duração. Finalmente, mostra-se como se podem deduzir com base nos mesmos resultados outras fórmulas simplificadas de cálculo da duração de Macaulay obtidas por outros investigadores.

  6. L’AMANT DE LA CHINE DU NORD, BY MARGUERITE DURAS: BOOK, FILM, NIGHT

    Directory of Open Access Journals (Sweden)

    Andréa Correa Paraiso Müller

    2016-06-01

    Full Text Available Na trajetória artística de Marguerite Duras, a relação entre cinema e literatura não se limita à passagem do texto à tela, mas compreende também o caminho inverso, da tela ao texto. Mais do que transformar filmes em livros, Duras fez literatura em diálogo com o cinema. No presente artigo, temos por objetivo analisar a maneira pela qual a linguagem cinematográfica perpassa a linguagem literária e vice-versa em L’Amant de la Chine du Nord (1991, texto que, embora chamado de romance por sua própria autora, organiza-se a partir de elementos próprios a um paratexto fílmico.

  7. Compactones, soluciones de ecuaciones no lineales con estructura tipo esferas duras

    OpenAIRE

    Máximo Agüero Granados; Jorge Bernal; Guadalupe Frias; Mauricio Paulin

    2001-01-01

    Se estudian ciertas soluciones de ecuaciones no lineales que modelan procesos físicos, que tienen semejanzas con estructuras coherentes del tipo de esferas duras, modelo de partículas muy usado en varias ramas de la física. Estas soluciones compactas (gotas, kinks, etcétera.) interactúan entre sí sólo a cortas distancias, porque no poseen colas infinitas como los solitones clásicos.

  8. Compactones, soluciones de ecuaciones no lineales con estructura tipo esferas duras

    Directory of Open Access Journals (Sweden)

    Máximo Agüero Granados

    2001-01-01

    Full Text Available Se estudian ciertas soluciones de ecuaciones no lineales que modelan procesos físicos, que tienen semejanzas con estructuras coherentes del tipo de esferas duras, modelo de partículas muy usado en varias ramas de la física. Estas soluciones compactas (gotas, kinks, etcétera. interactúan entre sí sólo a cortas distancias, porque no poseen colas infinitas como los solitones clásicos.

  9. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    Directory of Open Access Journals (Sweden)

    Elena Ivanovna Volkova

    2014-12-01

    Full Text Available In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. The punk-prayer may be interpreted as a feminine version of the Lord’s Prayer – Mater Nostra. Several corporeal narratives in the background – women’s dress code and rape debates, Virgin Mary’s belt, and its alleged miraculous ability to help women to deliver a baby – may be seen as allegories of feminist vs. patriarchal opposition in Russian religious and political culture.

  10. Muusikapassioon mõttepeeglis. Täna kõlab "Stabat Mater" / Anne Peäske

    Index Scriptorium Estoniae

    Peäske, Anne, 1946-

    2005-01-01

    Arvo Pärdi "Passio" ettekandest 11.sept. Rakvere Kolmainu kirikus. Elmo Lööve, Raivo Palmaru, Jaan Rääts, Toivo Tulev, Aarne Talvik, Ingmar Kurg, Olev Oja ja Eleonora Pärt Arvo Pärdi muusikast. A. Pärdi "Stabat Mater" ansambli Theatre of Voices esituses 14. sept. Rakvere Kolmainu kirikus

  11. Muusikapassioon mõttepeeglis. Täna kõlab "Stabat Mater" / Anne Peäske

    Index Scriptorium Estoniae

    Peäske, Anne, 1946-

    2005-01-01

    Arvo Pärdi "Passio" ettekandest 11.sept. Rakvere Kolmainu kirikus. Elmo Lööve, Raivo Palmaru, Jaan Rääts, Toivo Tulev, Aarne Talvik, Ingmar Kurg, Olev Oja ja Eleonora Pärt Arvo Pärdi muusikast. A. Pärdi "Stabat Mater" ansambli Theatre of Voices esituses 14. sept. Rakvere Kolmainu kirikus

  12. The Mater-Bi® biodegradable film for strawberry (Fragaria x ananassa Duch. mulching: effects on fruit yield and quality

    Directory of Open Access Journals (Sweden)

    Luigi Morra

    2016-08-01

    Full Text Available Two trials in different agricultural farms were carried out from October 2014 to June 2015 with the aim to assess the advantages linked to the substitution of the low density polyethylene (LDPE films for soil mulching with the Mater-Bi® biodegradable films in the strawberry cultivation under tunnel in Campania. Lifetime of biodegradable mulch and influence of type of mulch on the yield and the quality of cvs Sabrina and Fortuna were evaluated. Plants were cultivated on mulched, raised beds, high 40 cm from bottom soil. Mater-Bi® film was 20 µm thick while LDPE film was 50 mm thick. The physical-chemical parameters (firmness, pH, total soluble solid content, titratable acidity and skin colour and some bioactive compounds (total polyphenols, flavonoids, anthocyanins, antioxidant activity of fruits were determined by three samplings effected in consecutive months (from March to May 2015 of the harvest cycle. Biodegradable film guaranteed an effective mulch along the whole strawberry cycle (9-10 months including the time of drawing up of film. Yields of cv Sabrina on LDPE was 18% higher than those on Mater-Bi® while the opposite was detected in cv Fortuna (+10%. The physical-chemical parameters of fruits were not modified by the mulches. The content of the bioactive compounds, instead, resulted, in each time of sampling, significantly higher in fruits picked on Mater-Bi® based film.

  13. Efeito de diferentes durações do alongamento no desempenho de saltos unipodais

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Marchetti

    2014-06-01

    Full Text Available INTRODUÇÃO: A prática de exercícios de alongamento é muito comum como parte do aquecimento em diversas modalidades esportivas, porém, esta prática pode ser negativa para aqueles que desejam o aprimoramento da força e potência muscular, consequentemente, o rendimento dos saltos pode ficar reduzido após exercícios de alongamento, que depende do tempo de duração e intensidade do mesmo.OBJETIVO: Avaliar a influência do tempo de permanência no exercício alongamento sobre o desempenho do drop jump unilateralmente (unipodal.MÉTODOS: A amostra foi composta por 16 adultos jovens hígidos, com larga experiência em saltos. O protocolo de teste consistiu em realizar três drop jumps unipodais máximos a partir de uma plataforma de 15 cm sobre um tapete de salto (Hidrofit(r, antes e após duas durações (i.e. uma série 3 min. de um lado, e 6 min. para outro, a escolha foi de forma aleatória de alongamento dos músculos tríceps sural, utilizando uma intensidade entre 70-90% da percepção subjetiva de desconforto. A análise de variância ANOVA (2x2 foi utilizada para verificar diferenças para a altura de salto, tempo de contato e flexibilidade, utilizando um nível de significância de 5%.RESULTADOS: Apresentaram diferenças significativas entre condições pré e pós-alongamento para as durações de 3 e 6 minutos (P=0,002 e P=0,001, respectivamente, com a diminuição na altura máxima do salto. O tempo de contato foi maior apenas para a duração de 6 minutos (P=0,039.CONCLUSÃO: A realização de exercícios de alongamento do músculo tríceps sural por 3 ou 6 minutos de duração resulta na queda do desempenho do drop jumpunipodal, diminuição da altura do salto vertical (para 3 e 6 min. de duração e tempo de contato (apenas 6' min., reforçando a necessidade de mais debates na área sobre exercícios de alongamento antes daqueles de potência.

  14. Methyl Jasmonate-Induced Lipidomic and Biochemical Alterations in the Intertidal Macroalga Gracilaria dura (Gracilariaceae, Rhodophyta).

    Science.gov (United States)

    Kumari, Puja; Reddy, C R K; Jha, Bhavanath

    2015-10-01

    The role of exogenously added methyl jasmonate (MeJA), a lipid-derived signaling compound, in inducing oxidative stress in the marine red macroalga Gracilaria dura was investigated. MeJA at a concentration of 1-100 µM was a strong stimulant of reactive oxygen species (H(2)O(2), HO· and O(2) (·-)) (P < 0.05) causing considerable oxidative stress in G. dura. This further led to lipid peroxidation and degradation of the pigments Chl a and phycocyanin, with a concomitant increase in phycoerythrin. The MeJA-induced oxidative burst also led to the induction of a fatty acid oxidation cascade, resulting in the synthesis of hydroxy-oxylipins and the up-regulation of the 13-lipoxygenase pathway. Electrospray ionization-mass spectrometry-based shotgun lipidomic analysis revealed that monogalactosyldiacylglycerol (a chloroplastic glycerolipid) and phosphatidylcholine (extrachloroplastidic phopholipid) were the most affected lipid classes. The degradation of 18:3-fatty acid-containing monogalactosyldiacylglycerol inferred that it provided fatty acyl chains for the biosynthesis of 13-hydroperoxylinolenic acid, which was further directed towards either the jasmonate pathway or other alternative pathways of the fatty acid oxidation cascade, analogous to higher plants. Also, G. dura modulated the lipid acyl chains in such a way that no significant change was observed in the fatty acid profile of the treated thalli as compared with those of the control, except for C16:0, C16:1 (n-9), C20:3 (n-6) and C20:4 (n-6) (P < 0.05). Furthermore, MeJA caused the accumulation of phenolic compounds and the up-regulation of enzymes involved in secondary metabolism such as polyphenol oxidase, shikimate dehydrogenase and phenylalanine ammonia-lyase, indicating a shift towards secondary metabolism as a defense strategy to combat the induced oxidative stress.

  15. DuraLith Alkali-Aluminosilicate Geopolymer Waste Form Testing for Hanford Secondary Waste

    Energy Technology Data Exchange (ETDEWEB)

    Gong, W. L.; Lutz, Werner; Pegg, Ian L.

    2011-07-21

    The primary objective of the work reported here was to develop additional information regarding the DuraLith alkali aluminosilicate geopolymer as a waste form for liquid secondary waste to support selection of a final waste form for the Hanford Tank Waste Treatment and Immobilization Plant secondary liquid wastes to be disposed in the Integrated Disposal Facility on the Hanford Site. Testing focused on optimizing waste loading, improving waste form performance, and evaluating the robustness of the waste form with respect to waste variability.

  16. Discursos sobre a terapia de curta duração para o controle da tuberculose

    Directory of Open Access Journals (Sweden)

    Fernando Mitano

    Full Text Available RESUMO Objetivo: analisar os sentidos produzidos por meio das experiências e percepções dos profissionais de saúde sobre a implementação da estratégia do tratamento diretamente observado de curta duração para o controle da tuberculose. Método: estudo qualitativo realizado em Moçambique com 15 profissionais de saúde. Critérios de inclusão: atuação no Programa de Controle da Tuberculose há mais de um ano e estar em atividade profissional no período da entrevista. Para a coleta de dados foi usado um roteiro semiestruturado e as entrevistas realizadas individualmente foram gravadas. Resultados: emergiram três unidades discursivas: os procedimentos no tratamento do doente; o papel de Agente Comunitário da Saúde e da família; as dificuldades na aplicação do tratamento diretamente observado de curta duração. Conclusão: o tratamento da tuberculose requer um envolvimento constante da família, da comunidade e principalmente do Estado na criação e aplicação de políticas de formação dos recursos humanos e melhoria de infraestruturas.

  17. As durações do devir: como construir objetos-problema com a cartografia

    Directory of Open Access Journals (Sweden)

    Tania Mara Galli Fonseca

    2013-08-01

    Full Text Available Como podemos falar de objetos, duração e estabilidade em um mundo feito de vertigem e puro fluxo? Este artigo propõe a problematização do conceito de objeto na prática cartográfica para pensar a formação do cartógrafo. Para tanto, necessitamos ultrapassar o dualismo entre estável e instável. Por meio de conceitos como os de tensão e complexidade podemos produzir uma ontologia metaestável. Para produzir esta ontologia relacional, criativa e complexa, vamos usar uma caixa de ferramentas conceitual advinda de dois autores. De Henri Bergson tomaremos os conceitos de duração, intuição, seleção e sentido. De A. N. Whitehead tomaremos os conceitos de preensão, sentires e criação. A partir desses conceitos produziremos um conceito de objeto adequado ao empirismo transcendental e suas virtualidades, um conceito de objeto que ultrapasse os dualismos entre os fluidos e os sólidos: objeto-acontecimento, objeto-problema.

  18. Observações sobre o deslocamento da dura-máter nas punções cisternais laterais

    Directory of Open Access Journals (Sweden)

    Sandro L. Rossitti

    1990-12-01

    Full Text Available Estudo da anatomia dinâmica da punção cisternal lateral (suboccipital e C1-2 em cadáveres frescos, sob visão direta da dura-máter da junção crânio-vertebral. O deslocamento («tenda» da dura foi observado em todas as punções (n = 42, em média 3,46 mm (2 a 6 mm.

  19. MARGUERITE DURAS ET L’AUTOBIOGRAPHIE: LE PACTE DE VÉRITÉ EN QUESTION

    Directory of Open Access Journals (Sweden)

    Monique Pinthon

    2009-12-01

    Full Text Available La parution de manuscrits inédits de Marguerite Duras, en 2006, Les Cahiers de la guerre et autres textes, en même temps qu’elle met en lumière le processus de la création littéraire chez cette auteure, éclaire d’un jour nouveau l’appartenance générique du texte publié en 1984 et qui lui vaudra le prix Goncourt, L’Amant. Le premier cahier, le Cahier rose marbré, permet, en outre, de réfléchir aux relations complexes qui se tissent entre le roman des origines, le ro-man autobiographique Un barrage contre le Pacifique, L’Amant, présenté par l’auteure elle-même comme autobiographique et l’œuvre fictionnelle.

  20. Entre Bergson e Espinosa: eternidade ou duração?

    OpenAIRE

    2011-01-01

    Ao afirmar que a sua filosofia vê na duração o próprio tecido de que a realidade é feita, no último capítulo de A evolução criadora, Bergson explicita o seu projeto de construção de uma nova metafísica. Sabemos que a originalidade de sua empreitada está fundamentalmente nessa exigência da apreensão do tempo, sua transitoriedade e fluidez, como aquilo de que a realidade é feita. Trata-se de declarar a realidade temporal como definição da própria existência do mundo e da experiência humana sem...

  1. Le cru, le cuit et le pourri dans _Le vice-consul_ de Marguerite Duras

    Directory of Open Access Journals (Sweden)

    Hélène Caron

    2011-05-01

    Full Text Available Bien que plusieurs articles critiques aient déjà avancé de nouvelles perspectives sur le texte Le Vice-Consul (LVC de Marguerite Duras, l’analyse de la représentation de la nourriture dans ce roman n’a fait l’objet d’aucune étude. Cet article tente donc de combler cette lacune en proposant d’analyser les images du cru et du cuit, images qui se rejoignent sous les notions du pourri et de l’abject, tout en offrant quelques interprétations de l’un des passages critiques du roman où la folle mendiante croque la tête d’un poisson vivant.

  2. Polybrominated diphenyl ethers from the marine organisms Lendenfeldia dendyi and Sinularia dura with anti-MRSa activity

    Science.gov (United States)

    Bioassay-guided fractionation of the marine sponge Lendenfeldia dendyi and the soft coral Sinularia dura resulted in the isolation of five polybrominated diphenyl ethers (1-5). The structures of the isolated compounds were determined using spectroscopic methods(lD and 2D NMR) and HRMS analyses. The ...

  3. Anatomia comparativa da dura-máter de Sapajus libidinosus

    Directory of Open Access Journals (Sweden)

    Kleber F. Pereira

    2013-10-01

    Full Text Available O Sapajus libidinosus é um primata do novo mundo popularmente conhecido como macaco-prego, geograficamente distribuído por todo território sul-americano, possui características de inquietude e habilidade de manipulação de ferramentas para a obtenção de alimentos. Este estudo teve por objetivo descrever a morfologia dos seios da dura-máter de Sapajus libidinosus numa perspectiva comparativa. Foram utilizados um total de 3 animais adultos e machos oriundos da Universidade Federal de Goiás e fixados em solução aquosa de formaldeído 10%. No encéfalo de S. libidinosus, foi possível observar a fissura longitudinal, profunda e que divide o mesmo em dois hemisférios, esquerdo e direito. O lobo parietal e frontal apresenta-se relativamente lisoencefálico, mas com giros e sulcos bem definidos e no lobo occipital nota-se a predominância do aspecto lisencefálico. Nota-se a presença de 8 seios da dura-máter, que corresponde de modo geral às descrições para outros primatas como Pan, Papio e homem. Notamos a presença dos seios sagital dorsal, seio sagital ventral, seio transverso, seio reto, seio sigmóide, seio temporal e seio basilar, que são semelhantes a Pan, Papio e homem, a presença do seio parietal semelhante à Saimiri sciureus e a ausência do seio occipital, assim como em Macaca mullata. No macaco prego não foram observados os seios intracavernosos, seio esfenoparietal, seio petroso superior, seio petroso inferior, sendo estes descritos em Pan, Papio e Homem. Sendo assim, estes dados demonstram uma possível maior proximidade evolutiva entre Papio e Pan em relação ao homem do que o macaco Sapajus.

  4. Gustavo Corção: apóstolo da 'linha-dura'

    Directory of Open Access Journals (Sweden)

    Christiane Jalles de Paula

    2012-01-01

    Full Text Available O objetivo deste artigo é analisar as crônicas de Gustavo Corção na imprensa brasileira (Diário de Notícias e O Globo entre 1964 e 1968. A hipótese é que Gustavo Corção foi um dos artífices na esfera pública brasileira da legitimação das bases antidemocráticas da 'democracia' do regime militar. Além disso, a sua definição pela 'linha-dura' relacionou-se aos inimigos escolhidos, quase sempre personalidades católicas. Com isso poderemos perceber tanto aspectos da participação do laicato como da relação que se estabeleceu entre o Estado brasileiro e a Igreja católica no período em tela. O artigo procura demonstrar que é preciso mais atenção à recuperação dos sentidos de democracia que os grupos sociais mobilizaram naquele período, menos para justificar suas ações, e sim para entendê-las e contextualizá-las.

  5. Un lieu à l’oeuvre : « La chambre noire » de Marguerite Duras

    Directory of Open Access Journals (Sweden)

    Dominique Denes

    2010-05-01

    Full Text Available Partant du constat que chez Duras la poétique de l’espace oscille entre l’« outside » du « monde extérieur » et l’inside de « la vie matérielle » et domestique - autant de formules dont elle a fait des titres - comme elle-même se partage physiquement entre ses trois lieux de l’écrit, nous nous demanderons comment et jusqu’où ses lieux informent ses livres, et à l’inverse, comment l’écriture investit le lieu et se l’approprie. Emblématique est à cet égard la chambre des Roches noires érigée en concept de « chambre noire » de la création, cette chambre-livre avec vue se prêtant à la réflexion poétique comme à la projection dans l’imaginaire.

  6. Engineering-Scale Demonstration of DuraLith and Ceramicrete Waste Forms

    Energy Technology Data Exchange (ETDEWEB)

    Josephson, Gary B.; Westsik, Joseph H.; Pires, Richard P.; Bickford, Jody; Foote, Martin W.

    2011-09-23

    To support the selection of a waste form for the liquid secondary wastes from the Hanford Waste Immobilization and Treatment Plant, Washington River Protection Solutions (WRPS) has initiated secondary waste form testing on four candidate waste forms. Two of the candidate waste forms have not been developed to scale as the more mature waste forms. This work describes engineering-scale demonstrations conducted on Ceramicrete and DuraLith candidate waste forms. Both candidate waste forms were successfully demonstrated at an engineering scale. A preliminary conceptual design could be prepared for full-scale production of the candidate waste forms. However, both waste forms are still too immature to support a detailed design. Formulations for each candidate waste form need to be developed so that the material has a longer working time after mixing the liquid and solid constituents together. Formulations optimized based on previous lab studies did not have sufficient working time to support large-scale testing. The engineering-scale testing was successfully completed using modified formulations. Further lab development and parametric studies are needed to optimize formulations with adequate working time and assess the effects of changes in raw materials and process parameters on the final product performance. Studies on effects of mixing intensity on the initial set time of the waste forms are also needed.

  7. Metastatic disease of the brain: extra-axial metastases (skull, dura, leptomeningeal) and tumour spread

    Energy Technology Data Exchange (ETDEWEB)

    Maroldi, Roberto; Ambrosi, Claudia; Farina, Davide [University of Brescia, Department of Radiology, Brescia, BS (Italy)

    2005-03-01

    Extra-axial intracranial metastases may arise through several situations. Hematogenous spread to the meninges is the most frequent cause. Direct extension from contiguous extra-cranial neoplasms, secondary invasion of the meninges by calvarium and skull base metastases, and migration along perineural or perivascular structures are less common. Leptomeningeal invasion gives rise to tumour cell dissemination by the cerebrospinal fluid (CSF), eventually leading to neoplastic coating of brain surfaces. Contrast-enhanced magnetic resonance (MR) imaging is complementary to CSF examinations and can be invaluable, detecting up to 50% of false-negative lumbar punctures. MR findings range from diffuse linear leptomeningeal enhancement to multiple enhancing extra-axial nodules, obstructive communicating and non-communicating hydrocephalus. Both calvarial and epidural metastases infrequently transgress the dura, which acts as a barrier against tumour spread. Radionuclide bone studies are still a valuable screening test to detect bone metastases. With computed tomography (CT) and MR, bone metastases extending intracranially and primary dural metastases show the characteristic biconvex shape, usually associated with brain displacement away from the inner table. Although CT is better in detecting skull base erosion, MR is more sensitive and provides more detailed information about dural involvement. Perineural and perivascular spread from head and neck neoplasms require thin-section contrast-enhanced MR. (orig.)

  8. A novel compound isolated from Sclerochloa dura has anti-inflammatory effects

    Directory of Open Access Journals (Sweden)

    Bukhari Syed Majid

    2016-01-01

    Full Text Available The activation of PLA2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2 responsible for the enzymatic conversion of AA to eicosanoids, the non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. By using AA release assay as a guide for biological and anti-inflammatory activity, novel compound 1-O-(3-O-linolenoyl-6-deoxy-6-sulfo-α-D-glucopyranosyl-glycerol (1 together with five known compounds isovitexin, byzantionoside B, tricin 4’-O-(erythro-β-guaiacylglyceryl ether 7-O-β-glucopyranoside, 1-O-feruloyl glycerol and tricin 7-glucoside were isolated from the methanol extract of the aerial parts of Sclerochloa dura using LC techniques (Sephadex LH-20 column chromatography, preparative HPLC and semi-preparative HPLC. All isolated compounds were identified using spectroscopic NMR spectroscopy and MS spectrometry. Novel compound (1 was found to be an effective inhibitor of AA release with an IC50 value of 0.09 ± 0.03 mg mL-1.

  9. Beyond Gang Truces and Mano Dura Policies: Towards Substitutive Security Governance in Latin America

    Directory of Open Access Journals (Sweden)

    Moritz Schuberth

    2016-12-01

    Full Text Available With responses to urban violence receiving increasing academic attention, the literature on anti-gang efforts in Latin America has focused mainly on coercive 'mano dura' policies and cooperative gang truces. Yet, there remains a paucity of studies going beyond such carrots-and-sticks approaches towards gangs. To fill this gap, this study investigates the possibilities and limitations of substitutive security governance across Latin America and the Caribbean. More specifically, this article looks at Disarmament, Demobilisation and Reintegration (DDR programmes in Medellín, Armed Violence Reduction and Prevention (AVRP efforts in Haiti and Security Sector Reform (SSR in Guatemala and Rio de Janeiro. It will be argued that communities are driven to support gangs against the oppressive state when they are indiscriminately targeted through muscular operations. Likewise, engaging gangs in dialogue grants them legitimacy and further weakens the position of the state. Therefore, the only sustainable solution lies in substitutive security governance, which aims to replace the functions gangs fulfil for their members, sponsors, and the community in which they are nested with a modern and accountable state that is bound by the rule of law. Still, substitutive strategies vis-à-vis gangs have their own limitations, which can only be overcome by way of an integrated and coordinated framework.

  10. Verdad sublime y madre asesina en Christine V., versión de Marguerite Duras

    Directory of Open Access Journals (Sweden)

    Juliana González Holguín

    2016-01-01

    Full Text Available Todo relato es ficción, versión y, así mismo, verdad, bajo una u otra concepción de la misma, es decir, desde una perspectiva que se enfoca según la intención y la subjetividad de uno o más actores, de uno o más narradores. El texto de Marguerite Duras intitulado Sublime forcément sublime Christine V. involucra, por su contenido y su contexto, varias versiones que contrastan y se interrogan entre sí. La escritora se posiciona de tal manera que, a través de recursos propios del oficio literario, desentraña una verdad que puede no ajustarse a la realidad o al saber, pero que nos enfrenta a los límites de lo pulsional y lo ominoso.

  11. Efeitos da exposição de curta e longa duração ao etanol

    OpenAIRE

    Ferreira, Vania Maria Moraes

    2000-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. A participação das vias nitrérgicas e dos [receptores glutamatérgicos] ionotrópicos nos efeitos da exposição de curta e longa duração ao [etanol] foi avaliada no [hipocampo] de ratos. Inibidor e estimuladores das vias nitrérgicas indicam que estas vias opõem-se ao efeito [ansiolítico] do etanol e podem ter um papel importante no desenvolvimento da dependência ao álcool. A exposição de longa duração a...

  12. Digital radiographic evaluation of alveolar bone loss, density and lamina dura integrity on post splinting mandibular anterior with chronic periodontitis

    Science.gov (United States)

    Rafini, F.; Priaminiarti, M.; Sukardi, I.; Lessang, R.

    2017-08-01

    The healing of periodontal splinting can be detected both with clinical and radiographic examination. In this study, the alveolar bone was evaluated by radiographic digital periapical analysis. Periodontal tooth splinting is periodontal support therapy used to prevent periodontal injury during repair and regeneration of periodontal therapy. Radiographic digital periapical analysis of alveolar bone in the mandibular anterior region with chronic periodontitis and 2/3 cervical bone loss after three months of periodontal splinting. Eighty four proximal site (43 mesial and 41 distal) from 16 patients with chronic periodontitis and treated with spinting were examined by taking periapical digital radiographic at day 1 and 91. The bone loss, bone density and utility of lamina dura were evaluated. The statistical analysis after three months evaluation using T-test for bone loss, Wilcoxon sign rank test for bone density and utility lamina dura showed no significantly differences (pperiodontitis with 2/3 alveolar bone loss after three months splinting.

  13. Erosividade sob duas durações de intensidades máximas da chuva em Pelotas - RS

    OpenAIRE

    Fraga Damé, Rita de Cássia; Almeida Teixeira, Claudia Fernanda; Gonçalves, Ticiani; dos Santos, Jacira Porto; Quadro, Maurizio Silveira

    2012-01-01

    Na Equação Universal de Perdas de Solo (EUPS) a erosividade é o fator relacionado à chuva e expressa o seu potencial em provocar a erosão do solo, sendo necessário que se conheça a energia cinética da mesma e as máximas intensidades da chuva na duração de 30 min. Objetivou-se com este trabalho verificar e quantificar o impacto da duração da chuva, considerando 15 e 30 min, sobre o fator erosividade da EUPS. Para tanto foram utilizados 863 registros pluviográficos de chuva, no período de 19...

  14. Phacoemulsification in hard cataracts: the "chop, trip and free" technique Facoemulsificação em cataratas duras: "Faco rasteira"

    OpenAIRE

    José Marcos S. Gonçalves

    2004-01-01

    Very hard cataracts continue to be a challenge to phacoemulsification due to the difficulty in breaking the nucleus and also in separating the broken nucleus from the adjacent epinucleus. The present technique is the presentation of a surgical maneuver which uses the Nagahara chopper and the phaco tip to divide the nucleus (including the epinucleus) as a whole and then emulsify it using little time and not very much phaco power.Cataratas muito duras continuam sendo um desafio para a facoemuls...

  15. Effect of quorum sensing signals produced by seaweed-associated bacteria on carpospore liberation from Gracilaria dura

    Directory of Open Access Journals (Sweden)

    Ravindra Pal Singh

    2015-03-01

    Full Text Available Epiphytic and endophytic bacteria associated with green macroalgae Ulva (U. fasciata and U. lactuca and red macroalgae Gracilaria (G. corticata and G. dura have been identified from three different seasons to evaluate the effect of quorum sensing molecules on carpospores liberation from Gracilaria dura. The bacterial isolates belonging to the orders Bacillales, Pseudomonadales, Alteromonadales and Vibrionales were present in all seasons, whereas Actinomycetales and Enterobacteriales were confined to pre-monsoon and post-monsoon seasons, respectively. Among all the Gram-negative bacteria, seven isolates were found to produce different types of N-acyl homoserine lactones (AHLs. Interestingly, Shewanella algae produced five types of AHL: C4-HSL, HC4-HSL, C6-HSL, 3-oxo-C6-HSL and 3-oxo-C12-HSL. Subsequently, the AHLs producing bacterial isolates were screened for carpospore liberation from G. dura and these isolates were found to positively induce carpospore liberation over the control. Also, observed that carpospore liberation increased significantly in C4- and C6-HSL treated cystocarps. Sodium dodecyl sulfate and native polyacrylamide gel electrophoresis of the total protein of the C4- and C6-HSL-treated cystocarps showed two specific peptide bands of different molecular weights (50 kDa and 60 kDa as compared to the control, confirming their indirect effect on carpospore liberation.

  16. Effect of quorum sensing signals produced by seaweed-associated bacteria on carpospore liberation from Gracilaria dura.

    Science.gov (United States)

    Singh, Ravindra Pal; Baghel, Ravi S; Reddy, C R K; Jha, Bhavanath

    2015-01-01

    Epiphytic and endophytic bacteria associated with green macroalgae Ulva (U. fasciata and U. lactuca) and red macroalgae Gracilaria (G. corticata and G. dura) have been identified from three different seasons to evaluate the effect of quorum sensing (QS) molecules on carpospores liberation from Gracilaria dura. The bacterial isolates belonging to the orders Bacillales, Pseudomonadales, Alteromonadales, and Vibrionales were present in all seasons, whereas Actinomycetales and Enterobacteriales were confined to pre-monsoon and post-monsoon seasons, respectively. Among all the Gram-negative bacteria, seven isolates were found to produce different types of N-acyl homoserine lactones (AHLs). Interestingly, Shewanella algae produced five types of AHL: C4-HSL, HC4-HSL, C6-HSL, 3-oxo-C6-HSL, and 3-oxo-C12-HSL. Subsequently, the AHLs producing bacterial isolates were screened for carpospore liberation from G. dura and these isolates were found to positively induce carpospore liberation over the control. Also, observed that carpospore liberation increased significantly in C4- and C6-HSL treated cystocarps. Sodium dodecyl sulfate and native polyacrylamide gel electrophoresis of the total protein of the C4- and C6-HSL treated cystocarps showed two specific peptide bands of different molecular weights (50 kDa and 60 kDa) as compared to the control, confirming their indirect effect on carpospore liberation.

  17. Waste Acceptance Testing of Secondary Waste Forms: Cast Stone, Ceramicrete and DuraLith

    Energy Technology Data Exchange (ETDEWEB)

    Mattigod, Shas V.; Westsik, Joseph H.; Chung, Chul-Woo; Lindberg, Michael J.; Parker, Kent E.

    2011-08-12

    all the waste forms had leachability indices better than the target LI > 9 for technetium; (2) Rhenium diffusivity: Cast Stone 2M specimens, when tested using EPA 1315 protocol, had leachability indices better than the target LI > 9 for technetium based on rhenium as a surrogate for technetium. All other waste forms tested by ANSI/ANS 16.1, ASTM C1308, and EPA 1315 test methods had leachability indices that were below the target LI > 9 for Tc based on rhenium release. These studies indicated that use of Re(VII) as a surrogate for 99Tc(VII) in low temperature secondary waste forms containing reductants will provide overestimated diffusivity values for 99Tc. Therefore, it is not appropriate to use Re as a surrogate 99Tc in future low temperature waste form studies. (3) Iodine diffusivity: ANSI/ANS 16.1, ASTM C1308, and EPA 1315 tests indicated that the three waste forms had leachability indices that were below the target LI > 11 for iodine. Therefore, it may be necessary to use a more effective sequestering material than silver zeolite used in two of the waste forms (Ceramicrete and DuraLith); (4) Sodium diffusivity: All the waste form specimens tested by the three leach methods (ANSI/ANS 16.1, ASTM C1308, and EPA 1315) exceeded the target LI value of 6; (5) All three leach methods (ANS 16.1, ASTM C1308 and EPA 1315) provided similar 99Tc diffusivity values for both short-time transient diffusivity effects as well as long-term ({approx}90 days) steady diffusivity from each of the three tested waste forms (Cast Stone 2M, Ceramicrete and DuraLith). Therefore, any one of the three methods can be used to determine the contaminant diffusivities from a selected waste form.

  18. Comparação de diferentes metodologias para estimativa de curvas intensidade-duração-freqüência para Pelotas - RS

    National Research Council Canada - National Science Library

    Damé, Rita de C. F; Teixeira, Claudia F. A; Terra, Viviane S. S

    2008-01-01

    ... às curvas Intensidade-Duração-Freqüência (IDF). Diante disso, é preciso obter maneira de desenvolver metodologias de estimativas de curvas IDF, em locais que possuam pouco ou nenhum dado pluviográfico...

  19. Visualization of the network of primo vessels and primo nodes above the pia mater of the brain and spine of rats by using Alcian blue.

    Science.gov (United States)

    Lee, Ho-Sung; Lee, Byung-Cheon

    2012-10-01

    By spraying and injecting Alcian blue into the lateral ventricle, we were able to visualize the network of the nerve primo vascular system above the pia mater of the brain and spine of rats. Staining these novel structures above the pia mater with 4',6-diamidino-2-phenylindole demonstrated that they coexisted in cellular and extracellular DNA forms. The cellular primo node consisted of many cells surrounded by rod-shaped nuclei while the extracellular primo node had a different morphology from that of a general cell in terms of DNA signals, showing granular DNA in a threadlike network of extracellular DNA. Also, differently from F-actin in general cells, the F-actin in the primo vessel was short and rod-shaped. Light and transmission electron microscopic images of the PN showed that the nerve primo vascular system above the pia mater of the brain and spine was a novel dynamic network, suggesting the coexistence of DNA and extracellular DNA. Based on these data, we suggest that a novel dynamic system with a certain function exists above the pia mater of the central nerve system. We also discuss the potential of this novel network system in the brain and spine as related to acupuncture meridians and neural regeneration.

  20. DuraLith geopolymer waste form for Hanford secondary waste: Correlating setting behavior to hydration heat evolution

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Hui; Gong, Weiliang, E-mail: gongw@vsl.cua.edu; Syltebo, Larry; Lutze, Werner; Pegg, Ian L.

    2014-08-15

    Highlights: • Quantitative correlations firstly established for cementitious waste forms. • Quantitative correlations firstly established for geopolymeric materials. • Ternary DuraLith geopolymer waste forms for Hanford radioactive wastes. • Extended setting times which improve workability for geopolymer waste forms. • Reduced hydration heat release from DuraLith geopolymer waste forms. - Abstract: The binary furnace slag-metakaolin DuraLith geopolymer waste form, which has been considered as one of the candidate waste forms for immobilization of certain Hanford secondary wastes (HSW) from the vitrification of nuclear wastes at the Hanford Site, Washington, was extended to a ternary fly ash-furnace slag-metakaolin system to improve workability, reduce hydration heat, and evaluate high HSW waste loading. A concentrated HSW simulant, consisting of more than 20 chemicals with a sodium concentration of 5 mol/L, was employed to prepare the alkaline activating solution. Fly ash was incorporated at up to 60 wt% into the binder materials, whereas metakaolin was kept constant at 26 wt%. The fresh waste form pastes were subjected to isothermal calorimetry and setting time measurement, and the cured samples were further characterized by compressive strength and TCLP leach tests. This study has firstly established quantitative linear relationships between both initial and final setting times and hydration heat, which were never discovered in scientific literature for any cementitious waste form or geopolymeric material. The successful establishment of the correlations between setting times and hydration heat may make it possible to efficiently design and optimize cementitious waste forms and industrial wastes based geopolymers using limited testing results.

  1. A experiência emocional atualizadora em Gestalt-terapia de curta duração

    OpenAIRE

    Ênio Brito Pinto

    2009-01-01

    Apresenta-se e se discute o conceito, de Alexander, de experiência emocional corretiva, sob a ótica da abordagem gestáltica. Propõe-se que em Gestalt-terapia se deva falar em experiência emocional atualizadora. Discute-se a noção de neurose e de psicopatologia em Gestalt-terapia, bem como as implicações desses conceitos no processo de Gestalt-terapia de Curta Duração.

  2. A experiência emocional atualizadora em Gestalt-terapia de curta duração

    Directory of Open Access Journals (Sweden)

    Ênio Brito Pinto

    2009-04-01

    Full Text Available Apresenta-se e se discute o conceito, de Alexander, de experiência emocional corretiva, sob a ótica da abordagem gestáltica. Propõe-se que em Gestalt-terapia se deva falar em experiência emocional atualizadora. Discute-se a noção de neurose e de psicopatologia em Gestalt-terapia, bem como as implicações desses conceitos no processo de Gestalt-terapia de Curta Duração.

  3. Quantidade e Duração Silábicas em Português do Brasil

    Directory of Open Access Journals (Sweden)

    CAGLIARI Luiz Carlos

    1998-01-01

    Full Text Available Análise das relações existentes entre as predições dos modelos fonológicos não-lineares (em especial, o de Hayes, 1995 a respeito da quantidade das sílabas e a efetiva realização fonética dessas sílabas em termos de duração, através da consideração de dados extraídos do Projeto "Gramática do Português Falado".

  4. La baja de largo plazo en los precios de las drogas duras: una explicación

    Directory of Open Access Journals (Sweden)

    Leonardo Raffo López

    2015-07-01

    Full Text Available El propósito de esta investigación es avanzar en la compresión de los mercados ilegales de drogas duras y explicar la baja de largo plazo que se presentó en los precios de los estupefacientes durante las décadas anteriores. Para ello, siguiendo el enfoque de Poret y Téjedo (2006, y teniendo en cuenta la influencia de las redes de tráfico y distribución de las drogas ilícitas, se desarrolló un modelo analítico que permite entender el comportamiento de los mercados de ventas finales de drogas ilegales. Esto resulta novedoso en el ámbito de la economía del crimen y, en particular, en el de la teoría económica de los bienes ilegales. El modelo permitió probar varios resultados importantes, entre ellos, que la expansión y la densificación de las redes de tráfico y distribución de drogas son factores que explican la baja de largo plazo en los precios de las drogas duras.

  5. Uncover the mantle: rediscovering Gregório Lopes palette and technique with a study on the painting "Mater Misericordiae"

    Science.gov (United States)

    Antunes, Vanessa; Candeias, António; Oliveira, Maria J.; Carvalho, Maria L.; Dias, Cristina Barrocas; Manhita, Ana; Francisco, Maria J.; Costa, Sónia; Lauw, Alexandra; Manso, Marta

    2016-11-01

    Gregório Lopes (c. 1490-1550) was one of the most prominent painters of the renaissance and Mannerism in Portugal. The painting "Mater Misericordiae" made for the Sesimbra Holy House of Mercy, circa 1535-1538, is one of the most significant works of the artist, and his only painting on this theme, being also one of the most significant Portuguese paintings of sixteenth century. The recent restoration provided the possibility to study materially the painting for the first time, with a multianalytical methodology incorporating portable energy-dispersive X-ray fluorescence spectroscopy, scanning electron microscopy-energy-dispersive spectroscopy, micro-X-ray diffraction, micro-Raman spectroscopy and high-performance liquid chromatography coupled to diode array and mass spectrometry detectors. The analytical study was complemented by infrared reflectography, allowing the study of the underdrawing technique and also by dendrochronology to confirm the date of the wooden panels (1535-1538). The results of this study were compared with previous ones on the painter's workshop, and significant differences and similitudes were found in the materials and techniques used.

  6. Archaeometric analysis of Roman bronze coins from the Magna Mater temple using solid-state voltammetry and electrochemical impedance spectroscopy.

    Science.gov (United States)

    Di Turo, Francesca; Montoya, Noemí; Piquero-Cilla, Joan; De Vito, Caterina; Coletti, Fulvio; Favero, Gabriele; Doménech-Carbó, Antonio

    2017-02-22

    Voltammetry of microparticles (VMP) and electrochemical impedance spectroscopy (EIS) techniques, complemented by SEM-EDX and Raman spectroscopy, were applied to a set of 15 Roman bronze coins and one Tessera from the temple of Magna Mater (Rome, Italy). The archaeological site, dated back between the second half and the end of the 4th century A.D., presented a complicated stratigraphic context. Characteristic voltammetric patterns for cuprite and tenorite for sub-microsamples of the corrosion layers of the coins deposited onto graphite electrodes in contact with 0.10 M HClO4 aqueous solution yielded a grouping of the coins into three main groups. This grouping was confirmed and refined using EIS experiments of the coins immersed in air-saturated mineral water using the reduction of dissolved oxygen as a redox probe. The electrochemical grouping of coins corroborated the complex stratigraphy of the archaeological site and, above all, the reuse of the coins during the later periods due to the economic issues related to the fall of the Roman Empire.

  7. Dural metastases from disseminated prostate cancer clinically mimicking a benign reactive condition of the dura: case report and review of the literature.

    Science.gov (United States)

    Gunia, S; Ecke, T; Wohlfarth, B; Koch, S; Erbersdobler, A

    2011-01-01

    Dural spread from prostate cancer (PC) is exceedingly uncommon. We report on a 62-year-old man suffering from disseminated PC with osseous metastases who presented with a parietal skull metastasis along with a circumscribed nodular thickening of the adjacent dura. Magnetic resonance imaging findings suggested a benign reactive condition of the dura which, however, histologically turned out to be a dural metastasis. Therefore, the present case report stresses the notion that very rarely, disseminated PC might present with clinically unsuspected dural metastases radiologically mimicking a benign condition.

  8. Visibility of lamina dura and periodontal space on periapical radiographs and its comparison with cone beam computed tomography

    Directory of Open Access Journals (Sweden)

    Nimish Prakash

    2015-01-01

    Full Text Available Objectives: To retrospectively evaluate the subjective quality of images of cone beam computed tomography and compare with periapical radiographs (PR to determine whether lamina dura (LD and periodontal ligament (PDL space can be detected and reported. Study Design: Sixty scans for anterior and posterior teeth with PR were included and scored on four point subjective scale. Scores assessed using Wilcoxon Signed rank test with the level of statistical significance P < 0.05. Results: Maximum number of ties for LD in anteriors was seen in coronal section (16 and in posteriors with sagittal section (17. Assessing PDL space in anteriors, high number of ties was seen with coronal section (25 and sagittal section (21, while for posteriors showed a high number of ties in all sections. Conclusions: LD could be observed and reported in coronal section for anteriors and in sagittal section for posteriors and PDL space in all the sections for both anteriors and posteriors.

  9. Selenium and spermine alleviate cadmium induced toxicity in the red seaweed Gracilaria dura by regulating antioxidants and DNA methylation.

    Science.gov (United States)

    Kumar, Manoj; Bijo, A J; Baghel, Ravi S; Reddy, C R K; Jha, Bhavanath

    2012-02-01

    The protective role of exogenously supplied selenium (Se) and polyamines (PAs) such as putrescine (Put) and spermine (Spm) in detoxifying the cadmium (Cd) induced toxicity was studied in the marine red alga Gracilaria dura in laboratory conditions. The Cd exposure (0.4 mM) impede the growth of alga while triggering the reactive oxygen species (ROS viz. O(2)(•-) and H(2)O(2)) generation, inhibition of antioxidant system, and enhancing the lipoxygenase (LOX) activity, malondialdehyde (MDA) level and demethylation of DNA. Additions of Se (50 μM) and/or Spm (1 mM) to the culture medium in contrast to Put, efficiently ameliorated the Cd toxicity by decreasing the accumulation of ROS and MDA contents, while restoring or enhancing the level of enzymatic and nonenzymatic antioxidants and their redox ratio, phycobiliproteins and phytochelatins, over the controls. The isoforms of antioxidant enzymes namely superoxide dismutase (Mn-SOD, ~150 kDa; Fe-SOD ~120 kDa), glutathione peroxidase (GSH-Px, ~120 and 140 kDa), glutathione reductase (GR, ~110 kDa) regulated differentially to Se and/or Spm supplementation. Furthermore, it has also resulted in enhanced levels of endogenous PAs (specially free and bound insoluble Put and Spm) and n-6 PUFAs (C20-3, n-6 and C20-4, n-6). This is for the first time wherein Se and Spm were found to regulate the stabilization of DNA methylation by reducing the events of cytosine demethylation in a mechanism to alleviate the Cd stress in marine alga. The present findings reveal that both Se and Spm play a crucial role in controlling the Cd induced oxidative stress in G. dura.

  10. Closing the dura: dural hitching versus surgicel and tisseel overlay graft in craniocervicaldecompression for Chiari 1 malformation.

    Science.gov (United States)

    Tonkins, Michael; Farooqi, Naeem; Ahmed, Rohan; Sinha, Saurabh; Bhattacharyya, Debapriya

    2017-03-02

    This study compares dural hitching to surgicel and tisseel overlay graft following craniocervical decompression and C1 laminectomy with simple durotomy for Chiari I malformation. Outcome measures were syrinx decompression, headache resolution and complication rates. A retrospective analysis of case notes was conducted. Patients who had undergone craniocervical decompression (CCD) were grouped by method of dural closure. Outcomes compared were rates of syrinx decompression, headache resolution, and post-operative complications. Statistical analysis was conducted using SPSS v20. We identified 32 adult patients for inclusion in this study. 53.1% (n = 17) had asyrinx, and 78.1% (n = 25) had a pre-operative headache. All were treated with suboccipital craniectomy, C1 laminectomy (with or without C2 laminectomy), and durotomy. The dura was either left open by dural hitching (n = 23) or closed with surgicel and tisseel overlay graft (n = 9). We found a statistically significant association between the method of dural closure and the rate of syrinx resolution. Resolution occurred in 91.7% (n = 11) of the hitching group, compared to 20.0% (n = 1) of the overlay graft group: Χ(2)(1) = 5.6, p = .018. There were no statistically significant differences between the two groups in the rates of headache resolution or other complications. In patients with symptomatic Chiari I malformation and associated syringomyelia, syrinx resolution is more likely if the dura is hitched open rather than closed bysurgicel and tisseel overlay graft after durotomy.

  11. Uso de tecnologia leve-dura nas práticas de enfermagem: análise de conceito

    Directory of Open Access Journals (Sweden)

    Leidiane Minervina Moraes de Sabino

    2016-01-01

    Full Text Available Objetivo: establecer el concepto de tecnología blanda-dura en las prácticas de enfermería. Materiales y métodos: estudio reflexivo, con aplicación del método de análisis conceptual de Walker e Avant, que utiliza los siguientes pasos: selección de un concepto; deter- minación de los objetivos de análisis, de los atributos definidores; identificación de un caso modelo y contrario, e identificación de los antecedentes y las consecuencias. El estudio se llevó a cabo desde la búsqueda en bases de datos de las producciones científicas disponi- bles en ambiente virtual, en el periodo de abril y mayo de 2014. Resultados y discusión: inicialmente, el concepto de tecnología estaba relacionado al de técnica; con el del tiempo, sufrió cambios y pasó a relacionarse con los aspectos subjetivos y objetivos del cuidador. La tecnología blanda-dura sobrepasa los conocimientos tecnológicos estructurados y presenta libertad que les permite a los profesionales diversas posibilidades de acción. El uso de tecnologías en el cuidado de la enfermería es capaz de promover la salud e intensificar el vín- culo entre profesional y cliente. Conclusión: el método de Walker e Avant posibilita demarcar los aspectos y la formación de un concepto desde atributos, antecedentes y consecuentes, además de analizar la utilización de los términos en la práctica.

  12. Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.

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    Jonathan A Coles

    2015-04-01

    Full Text Available Peripheral infection by Trypanosoma brucei, the protozoan responsible for sleeping sickness, activates lymphocytes, and, at later stages, causes meningoencephalitis. We have videoed the cortical meninges and superficial parenchyma of C56BL/6 reporter mice infected with T.b.brucei. By use of a two-photon microscope to image through the thinned skull, the integrity of the tissues was maintained. We observed a 47-fold increase in CD2+ T cells in the meninges by 12 days post infection (dpi. CD11c+ dendritic cells also increased, and extravascular trypanosomes, made visible either by expression of a fluorescent protein, or by intravenous injection of furamidine, appeared. The likelihood that invasion will spread from the meninges to the parenchyma will depend strongly on whether the trypanosomes are below the arachnoid membrane, or above it, in the dura. Making use of optical signals from the skull bone, blood vessels and dural cells, we conclude that up to 40 dpi, the extravascular trypanosomes were essentially confined to the dura, as were the great majority of the T cells. Inhibition of T cell activation by intraperitoneal injection of abatacept reduced the numbers of meningeal T cells at 12 dpi and their mean speed fell from 11.64 ± 0.34 μm/min (mean ± SEM to 5.2 ± 1.2 μm/min (p = 0.007. The T cells occasionally made contact lasting tens of minutes with dendritic cells, indicative of antigen presentation. The population and motility of the trypanosomes tended to decline after about 30 dpi. We suggest that the lymphocyte infiltration of the meninges may later contribute to encephalitis, but have no evidence that the dural trypanosomes invade the parenchyma.

  13. The "RESEAU MATER": An efficient infection control for endometritis, but not for urinary tract infection after vaginal delivery.

    Science.gov (United States)

    Ayzac, Louis; Caillat-Vallet, Emmanuelle; Girard, Raphaële; Berland, Michel

    2016-09-01

    "RESEAU MATER" is useful to monitor nosocomial infections in maternity and contributes to the decreasing trend of it, since its implementation. Specifically, this network demonstrates its efficiency in the control of endometritis following vaginal deliveries, but not in the control of urinary tract infections. The aim of this study is to determine whether the difference between the control of endometritis and of urinary tract infection could be explained by an unsuitable regression model or by an unsuitable care policy concerning urinary cares. This study includes (1) the analysis of historic data of the network and (2) the description of French guidelines for maternity cares and available evaluations, concerning endometritis and urinary tract infection prevention. Univariate and multivariate odds ratios (ORs) were calculated for the total study period of 1999-2013, for these infections and their risk factors. The endometritis frequency is decreasing, in association with no significant evolution of associated risk factors, but urinary tract infection frequency is constant, in association with a increasing trend of its risk factors such as intermittent catheterization and epidural analgesia. In French guidelines, all preventive measures against endometritis are clearly broadcasted by all field operators, and repeated audits have reinforced the control of their application. But preventive measures against urinary tract infection seem to be broadcasted exclusively in the circle of infection prevention agencies and not in the obstetrics societies or in the Health Ministry communication. Urinary tract infection prevention requires a clearer public and professional policy in favor of a more efficient urinary cares, with a specific target to maternity.

  14. Mensuração do deslocamento da dura-máter na punção suboccipital mediana

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    Sandro L. Rossitti

    1991-09-01

    Full Text Available Estudo da anatomia dinâmica da punção suboccipital mediana da cisterna magna em cadáveres frescos. O deslocamento («tenda» da dura-máter foi observado em todas as punções (n = 30, medindo 3,12 (2,0-4,2 mm.

  15. Development, identification and validation of CAPS marker for SHELL trait which governs dura, pisifera and tenera fruit forms in oil palm (Elaeis guineensis Jacq.).

    Science.gov (United States)

    Babu, B Kalyana; Mathur, R K; Kumar, P Naveen; Ramajayam, D; Ravichandran, G; Venu, M V B; Babu, S Sparjan

    2017-01-01

    The oil palm fruit forms (dura, pisifera and tenera) governed by the shell thickness gene (Sh) plays a major role in identification of fruit type and also influences palm oil yield. Identification of desired fruit type is a major asset to the breeders and oil palm workers for applications in breeding, seed certification and to reduce time, space and money spent on identification of fruit form. In the present study, we developed Sh gene specific primer pairs and bulk segregant analysis was done using 300 genomic and 8 genic SSR markers. We identified one cleaved amplified polymorphic site (CAPS) marker for differentiation of oil palm fruit type which produced two alleles (280 and 250bp) in dura genotypes, three alleles in tenera genotypes (550, 280, and 250bp) and one allele in pisifera genotypes (550bp). The shell allele sequencing results showed that two SNPs were present, of which SNP2 contributed for variation of fruit forms. The nucleotide 'A' was present in only dura genotypes, where as 'T' was present only in pisifera genotypes, which in turn led to the change of amino acid lysine to aspargine. The identified CAPS marker was validated on 300 dura, 25 pisifera and 80 tenera genotypes, 80 dura/ pisifera cross progenies and 60 lines of tenera/ tenera cross progeny. Association mapping of marker data with phenotypic data of eight oil yield related traits resulted in identification of seven significant QTLs by GLM approach, four by MLM approach at a significant threshold (P) level of 0.001. Significant QTLs were identified for fruit to bunch and oil to bunch traits, which explained R2 of 12.9% and 11.5% respectively. The CAPS marker used in the present study facilitate selection and timely distribution of desirable high yielding tenera sprouts to the farmers instead of waiting for 4-5 years. This saves a lot of land, time and money which will be a major breakthrough to the oil palm community.

  16. A dor durante a punção do canal vertebral e sua relação com a inervação do ligamento amarelo, da dura-máter e do ligamento longitudinal posterior El dolor durante la punción del canal vertebral y su relación con la inervación del ligamento amarillo, de la dura-máter y del ligamento longitudinal posterior Pain during spinal canal puncture and its relationship with ligamentum flavum, dura-mater and posterior longitudinal ligament innervation

    OpenAIRE

    2004-01-01

    JUSTIFICATIVA E OBJETIVOS: A dor durante a punção raquidiana é um sinal de alarme, indicando que a ponta da agulha tocou numa estrutura nervosa. Por este motivo, se o paciente acusar dor durante a punção, é obrigatória a interrupção da técnica. A solução anestésica não deverá ser injetada para evitar uma possível lesão de raiz nervosa ou da medula espinhal. Deve-se recuar a agulha e mudar sua direção antes de novo avanço. O relato de dor é totalmente impossível se o paciente estiver adormecid...

  17. Hematoma subdural após punção inadvertida da dura-máter: relato de caso

    Directory of Open Access Journals (Sweden)

    Wallace Lage Duarte

    2008-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A cefaléia pós-punção da dura-máter é complicação bastante conhecida das anestesias subaracnóidea e peridural, e o tratamento mais difundido é o tampão sangüíneo. O tampão sangüíneo alivia totalmente a cefaléia na grande maioria dos pacientes, e nos demais não há melhora ou, apenas, melhora parcial. Nesses casos, é prudente buscar diagnósticos diferenciais, como o hematoma subdural ou pneumoencéfalo. Os métodos de imagem são extremamente úteis nessas situações. O objetivo deste relato foi apresentar o caso de um paciente que desenvolveu hematoma subdural intracraniano após punção inadvertida da dura-máter em anestesia peridural. RELATO DO CASO: Paciente do sexo masculino, 47 anos, 147 kg, 1,90 m, estado físico ASA II, foi admitido para realização de dermolipectomia abdominal, após ter-se submetido à gastroplastia redutora. Durante anestesia peridural, houve perfuração acidental da dura-máter. O paciente evoluiu com sintomas de cefaléia pós-punção da dura-máter que foram tratados com tampão sangüíneo, com melhora parcial. Houve, posteriormente, piora da cefaléia, e a ressonância nuclear magnética de encéfalo mostrou hematoma subdural intracraniano, que foi tratado clinicamente. Houve melhora progressiva, com recuperação total após 30 dias. CONCLUSÕES: A ocorrência de hematoma subdural é complicação rara, mas grave da perfuração de dura-máter. O diagnóstico é difícil e deve ser sempre cogitado quando a cefaléia pós-punção da dura-máter não se resolve com o tampão sangüíneo ou piora com sua realização. No esclarecimento diagnóstico é fundamental o auxílio de um método de imagem.

  18. Nutrição materna e duração da amamentação em uma coorte de nascimento de Pelotas, RS

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    Gigante Denise Petrucci

    2000-01-01

    Full Text Available OBJETIVO: Os efeitos da situação nutricional materna sobre a duração da amamentação são inconsistentes na literatura. O estudo realizado objetivou investigar esses efeitos em uma coorte de nascimentos hospitalares. MÉTODOS: Foram estudadas 977 mulheres que tiveram filhos no ano de 1993, em Pelotas (representando 20% dos nascimentos ocorridos nesse ano. Os efeitos da situação nutricional materna e de variáveis socioeconômicas e demográficas sobre a prevalência de amamentação aos seis meses de idade e sobre a duração da amamentação foram analisados pela regressão logística e de Cox, respectivamente. RESULTADOS: A análise multivariada mostrou que a prevalência de amamentação foi mais alta entre mulheres que iniciaram a gestação com 49 kg ou mais (RO = 1,31; IC95% 1,04 - 1,64, e a associação com altura materna foi no limiar da significância (p=0,06. A regressão de Cox mostrou um efeito protetor, no limiar da significância, do maior peso pré-gestacional sobre o desmame (RR = 0,91; IC95% 0,82 -- 1,01. Não houve diferença na duração da amamentação quanto à altura materna. O ganho de peso gestacional não mostrou associação com prevalência ou duração da amamentação. Idade materna, paridade, hábito de tabagismo e idade gestacional estiveram associadas significativamente com a amamentação em ambas as análises. Renda familiar mostrou associação com a prevalência de amamentação aos seis meses e o peso ao nascer com a duração da amamentação. CONCLUSÕES: Peso pré-gestacional foi um melhor preditor para duração da amamentação do que o ganho de peso gestacional.

  19. Morphology and protein molecular weight analysis from three variant of oil palm pollen; Dura, Pisifera, and Tenera

    Science.gov (United States)

    Priambodo, R.; Witarto, A. B.; Salamah, A.; Setiorini, Triyono, D.; Bowolaksono, A.

    2017-07-01

    Oil palm is a plant that widely cultivated in Indonesia, with an area of about 11 million hectares in 2014. There are three main variants that most cultivated; Dura, Pisifera, and Tenera. Oil palm pollen was spread through the wind. The very wide area of oil palm plantation and those characteristics of oil palm pollen dispersion makes oil palm pollen may give negative effect to the people around plantation, such as an allergy. The research on the morphology and protein characters of the oil palm pollen from three variants has not done yet. This research aims to observe the morphology and protein character from three variants of oil palm pollen. The study begins with the pollen collection from three variants of oil palm. Oil palm pollen was observed using the light and scanning electron microscope. Oil palm pollen protein was extracted and the molecular weight of these proteins was analyzed. The result of this research was the morphology character from three variants of oil palm pollen have successfully been observed. Those three variant of oil palm have no differences structures; triangular shaped with round edge, tricolpate with connected colpus aperture, psilate exine ornamentation at the front side and peripheral side, while at the back side has microreticulate exine ornamentation. Three variants of oil palm pollen protein show the same characteristics. The molecular weight of the protein was ranged from 10-00 KDa. The information can be useful for the next research to figure out component of proteins inside the oil palm pollen.

  20. Genetic performance and general combining ability of oil palm Deli dura x AVROS pisifera tested on inland soils.

    Science.gov (United States)

    Noh, A; Rafii, M Y; Saleh, G; Kushairi, A; Latif, M A

    2012-01-01

    The performance of 11 oil palm AVROS (Algemene Vereniging van Rubberplanters ter Oostkust van Sumatra) pisiferas was evaluated based on their 40 dura x pisifera (DxP) progenies tested on inland soils, predominantly of Serdang Series. Fresh fruit bunch (FFB) yield of each pisiferas ranged from 121.93 to 143.9 kg palm⁻¹ yr⁻¹ with trial mean of 131.62 kg palm⁻¹ yr⁻¹. Analysis of variance (ANOVA) showed low genetic variability among pisifera parents for most of the characters indicating uniformity of the pisifera population. This was anticipated as the AVROS pisiferas were derived from small population and were inbred materials. However, some of the pisiferas have shown good general combining ability (GCA) for certain important economic traits. Three pisiferas (P1 (0.174/247), P3 (0.174/498), P11 (0.182/308)) were identified of having good GCA for FFB yield while pisiferas P1 (0.174/247), P10 (0.182/348), and P11 (0.182/308) were good combiners for oil-to-bunch ratio (O/B). The narrow genetic base of these materials was the main obstacle in breeding and population improvement. However, efforts have been made to introgress this material with the vast oil palm germplasm collections of MPOB for rectifying the problem.

  1. Phacoemulsification in hard cataracts: the "chop, trip and free" technique Facoemulsificação em cataratas duras: "Faco rasteira"

    Directory of Open Access Journals (Sweden)

    José Marcos S. Gonçalves

    2004-08-01

    Full Text Available Very hard cataracts continue to be a challenge to phacoemulsification due to the difficulty in breaking the nucleus and also in separating the broken nucleus from the adjacent epinucleus. The present technique is the presentation of a surgical maneuver which uses the Nagahara chopper and the phaco tip to divide the nucleus (including the epinucleus as a whole and then emulsify it using little time and not very much phaco power.Cataratas muito duras continuam sendo um desafio para a facoemulsificação devido à dificuldade em quebrar o núcleo e também em separar este pedaço quebrado do epinúcleo adjacente. Esta técnica é a apresentação de uma manobra cirúrgica ("Faco rasteira", em que se utiliza o Nagahara "chopper" e a caneta de faco para dividir o núcleo (incluindo o epinúcleo em sua totalidade e assim emulsificá-lo, utilizando tempo e poder de ultra-som baixo.

  2. Viagens “independentes” de longa duração: política, economia e cultivo da mobilidade

    Directory of Open Access Journals (Sweden)

    Igor Monteiro Silva

    2016-08-01

    Full Text Available As viagens “independentes” de longa duração são caracterizadas, por seus praticantes, a partir da distinção frente às “práticas turísticas institucionalizadas”. Enquanto os primeiros buscam uma experiência de deslocamento mais alargada em termos espaciais e temporais, priorizando o contato íntimo com as comunidades visitadas e demais viajantes, os turistas – segundo os termos desse segmento conhecido popularmente como mochileiro ou backpacker – resignam-se ao abrigo de um tipo de “bolha ambiental”, não prescindindo em suas viagens das mediações de agências e guias. A presente comunicação objetiva, justamente, explorar este universo de práticas e sentidos construído pelos sujeitos das viagens “independentes”, procurando compreender, mais detidamente, a relação estabelecida entre estes viajantes e suas comunidades de origem.

  3. DuraLith geopolymer waste form for Hanford secondary waste: correlating setting behavior to hydration heat evolution.

    Science.gov (United States)

    Xu, Hui; Gong, Weiliang; Syltebo, Larry; Lutze, Werner; Pegg, Ian L

    2014-08-15

    The binary furnace slag-metakaolin DuraLith geopolymer waste form, which has been considered as one of the candidate waste forms for immobilization of certain Hanford secondary wastes (HSW) from the vitrification of nuclear wastes at the Hanford Site, Washington, was extended to a ternary fly ash-furnace slag-metakaolin system to improve workability, reduce hydration heat, and evaluate high HSW waste loading. A concentrated HSW simulant, consisting of more than 20 chemicals with a sodium concentration of 5 mol/L, was employed to prepare the alkaline activating solution. Fly ash was incorporated at up to 60 wt% into the binder materials, whereas metakaolin was kept constant at 26 wt%. The fresh waste form pastes were subjected to isothermal calorimetry and setting time measurement, and the cured samples were further characterized by compressive strength and TCLP leach tests. This study has firstly established quantitative linear relationships between both initial and final setting times and hydration heat, which were never discovered in scientific literature for any cementitious waste form or geopolymeric material. The successful establishment of the correlations between setting times and hydration heat may make it possible to efficiently design and optimize cementitious waste forms and industrial wastes based geopolymers using limited testing results.

  4. MEMBANGUN KEUNGGULAN KOMPETITIF CPO MELALUI SUPPLY CHAIN MANAGEMENT: STUDI KASUS DI PT. EKA DURA INDONESIA, ASTRA AGRO LESTARI, RIAU

    Directory of Open Access Journals (Sweden)

    Setiadi Djohar

    2011-08-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Todays, Supply Chain Management (SCM becomes one icon of strategic factors to achieve a competitive advantage. This is a SCM case study in agroindustry especially crude palm oil (CPO at PT. Eka Dura Indonesia (PT EDI, Astra Agro Lestari, Riau. The objectives of study is mapping of SCM problems of PT EDI, especially about value advantage and productivity advantage. Beside that, the objectives is building a SCM simulation model as strategic tool for developing strategy to achieve a competitive advantage. A system approach and modeling is used to analyze SCM problems. This study is successfully to build SCM Model that consist of SCM Strategic Model and SCM Tactic Model. SCM Model is used for simulating some scenarios about site management, supply schedulling, and tank management to CPO forecasting. From this model, the study also develops strategy chain for SCM to achieve a competitive advantage

  5. Coeficientes para estimativas de precipitação com duração de 24 horas a 5 minutos para Jaboticabal

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    Paulo Nobukuni

    2005-06-01

    Full Text Available Dados de pluviosidade, identificados para cada data e local, foram digitados em computador e processados, utilizando-se um programa desenvolvido especificamente para este projeto. Com o programa foram localizadas as máximas intensidades de chuvas para diversos tempos de duração. Comparando-se os dados registrados para períodos de "1 dia" e aqueles obtidos para um período contínuo de 24 horas, obtidos neste trabalho com variação na quantidade de precipitação considerada no intervalo de um minuto, determinaram-se as relações existentes entre eles e, também, entre os de 24 horas e aqueles para durações menores do que 24 horas.

  6. 兔颈部硬脊膜表面及椎板旁神经分布的实验研究%Experimental study of nerve fibers' distribution and innervation on the surface of dura mater of spinal cord and lamina of vertebra in rabbits

    Institute of Scientific and Technical Information of China (English)

    左金良; 韩建龙; 韩庆森; 马英文; 秦川

    2006-01-01

    目的:观测兔颈部硬脊膜表面及椎板旁的神经分布规律,为颈性眩晕发病机理的研究提供实验依据.方法:20只新西兰兔,分为硬脊膜实验组及对照组、椎板旁实验侧及对照侧,分别于实验组(侧)(C6硬脊膜或C5椎板表面)喷涂辣根过氧化物酶(HRP)溶液、而对照组(侧)喷涂生理盐水,48h后切取双侧颈上神经节、颈下神经节(或星状神经节)及双侧脊神经节,按TMB法进行成色反应,光镜观察HRP标记细胞形态及其分布情况.利用辣根过氧化物酶逆行示踪技术,了解硬脊膜表面及椎板旁的神经分布规律.结果:硬脊膜实验组双侧C5~C7脊神经节内出现HRP标记细胞,椎板旁实验侧同侧C4~C6脊神经节内出现HRP标记细胞,交感神经节及对照组(侧)脊神经节内未出现标记细胞.结论:颈部硬脊膜表面的神经主要来自双侧脊神经节,相邻节段间有重叠分布;椎板旁的神经主要来自同侧脊神经节,且相邻节段间有重叠.

  7. Case Report: Intracranial peripheral primitive neuroectodermal tumor - Ewing′s sarcoma of dura with transcalvarial-subgaleal extension: An unusual radiological presentation

    Directory of Open Access Journals (Sweden)

    Bano Shahina

    2009-01-01

    Full Text Available The occurrence of the intracranial, peripheral, primitive, neuroectodermal tumor, Ewing′s sarcoma (pPNET-ES of the dura, is very rare. Immunophenotypical as well as genetic analyses play key roles in its diagnosis and differentiation from central PNET. We describe here the CT scan and MRI findings of an interesting case of intracranial pPNET-ES arising from the anterior falx cerebri with a trancalvarial-subgaleal extension.

  8. Comparação de diferentes metodologias para estimativa de curvas intensidade-duração-freqüência para Pelotas - RS Comparison of different methodologies to estimate intensity-duration-frequency curves for Pelotas - RS, Brazil

    National Research Council Canada - National Science Library

    Rita de C. F. Damé; Claudia F. A. Teixeira; Viviane S. S. Terra

    2008-01-01

    ... às curvas Intensidade-Duração-Freqüência (IDF). Diante disso, é preciso obter maneira de desenvolver metodologias de estimativas de curvas IDF, em locais que possuam pouco ou nenhum dado pluviográfico...

  9. Development, identification and validation of CAPS marker for SHELL trait which governs dura, pisifera and tenera fruit forms in oil palm (Elaeis guineensis Jacq.)

    Science.gov (United States)

    Babu, B. Kalyana; Mathur, R. K.; Kumar, P. Naveen; Ramajayam, D.; Ravichandran, G.; Venu, M. V. B.; Babu, S. Sparjan

    2017-01-01

    The oil palm fruit forms (dura, pisifera and tenera) governed by the shell thickness gene (Sh) plays a major role in identification of fruit type and also influences palm oil yield. Identification of desired fruit type is a major asset to the breeders and oil palm workers for applications in breeding, seed certification and to reduce time, space and money spent on identification of fruit form. In the present study, we developed Sh gene specific primer pairs and bulk segregant analysis was done using 300 genomic and 8 genic SSR markers. We identified one cleaved amplified polymorphic site (CAPS) marker for differentiation of oil palm fruit type which produced two alleles (280 and 250bp) in dura genotypes, three alleles in tenera genotypes (550, 280, and 250bp) and one allele in pisifera genotypes (550bp). The shell allele sequencing results showed that two SNPs were present, of which SNP2 contributed for variation of fruit forms. The nucleotide ‘A’ was present in only dura genotypes, where as ‘T’ was present only in pisifera genotypes, which in turn led to the change of amino acid lysine to aspargine. The identified CAPS marker was validated on 300 dura, 25 pisifera and 80 tenera genotypes, 80 dura/ pisifera cross progenies and 60 lines of tenera/ tenera cross progeny. Association mapping of marker data with phenotypic data of eight oil yield related traits resulted in identification of seven significant QTLs by GLM approach, four by MLM approach at a significant threshold (P) level of 0.001. Significant QTLs were identified for fruit to bunch and oil to bunch traits, which explained R2 of 12.9% and 11.5% respectively. The CAPS marker used in the present study facilitate selection and timely distribution of desirable high yielding tenera sprouts to the farmers instead of waiting for 4–5 years. This saves a lot of land, time and money which will be a major breakthrough to the oil palm community. PMID:28192462

  10. The Correlations of Educational Service,Perceived College Support and College Students’ Commitment to Alma Mater%大学生母校承诺的心理结构及其影响因素研究

    Institute of Scientific and Technical Information of China (English)

    陈志霞; 张敏

    2014-01-01

    母校承诺是指大学生对母校的心理认同和情感依恋,培养大学生对母校的积极情感,是大学生情感教育的重要构成部分。研究结果表明:大学生母校承诺的心理结构包含认知承诺、感情承诺和责任承诺三个部分,高校教育服务质量通过母校支持感的部分中介作用对大学生母校承诺发挥积极影响。因此,高校应从认知、情感和责任三维角度来加强对学生母校情感的综合培养,通过提高高校教育服务质量和学生的母校支持感进而增强其母校承诺。%Commitment to Alma Mater is a kind of psychological identification and emotional attachment for Alma Mater of college students. The structure and mechanism of college students ’ commitment to Alma Mater are analyzed through both theoretical analysis and empirical research. The results are as follows:Commitment to Alma Mater is composed of three factors:cognitive commitment,affective commitment and obligation commitment, and students’ perceived college support plays a partially intermediary role in the relationship between the quality of college’s education and service and college students’ commitment to Alma Mater. In order to improve college students ’ commitment to Alma Mater , colleges and universities should educate college students ’ affection to Alma Mater from cognitive,affective,responsible aspects and improve the commitment to Alma Mater through enhancing the quality of college’s education and service and the perceived college support.

  11. On the Cultivation of Students' Sense of the Love for the Alma Mater during Higher Education%培养学生爱校情怀在高等教育中的作用和途径

    Institute of Scientific and Technical Information of China (English)

    赵慧

    2011-01-01

    The survey from MyCOS shows that the graduates from colleges and universities are not willing to recommend their alma mater to the public at present.In order to increase the students' acceptability of their alma mater,colleges and universities should not only make a great effort to do a good job in other aspects,but also focus on the cultivation of students' sense of the love for the alma mater in the process of higher education.The thesis mainly indicates the cultivation of students' sense of the love for the alma mater from the following three points.%麦可思公司的调查结果显示,目前各类高校的毕业生对母校的推荐度普遍较低。要提高学生对学校的认可度,高校在努力做好其它各项工作的同时,应该把大学生爱校情怀的培养贯穿于高等教育的始终。可以通过抓住新生入学契机,加强培养学生爱校情怀,搭建学生爱校情怀的平台,注重学生的毕业教育等三条途径现实对大学生爱校情怀的培养。

  12. Influencia de concentração de prilocaina associada a felipressina e epinefrina sobre a duração e intensidade da anestesia

    OpenAIRE

    Maria Esperança Rabelo Junqueira

    1990-01-01

    Estudou-se neste trabalho, conforme foi proposto, a interação sinérgica entre epinefrina e felipressina sobre a duração e intensidade da anestesia subcutânea, em dorso de cobaio, pela prilocaína em concentrações variadas... Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital The purpose of this paper is the study of the synergical interaction of epinephrine and felipressine on the duration and intensity of the subcutaneous anesthesia by prilocaine in ...

  13. [Alternate method for closure of oro-antral fistulas. Plastic covering of jaw opening with lyophilized Dura and alcoholic solution of Prolamin].

    Science.gov (United States)

    Kinner, U; Frenkel, G

    1990-11-01

    The operative closure of an oroantral fistula due to tooth extractions by the method of Rehrmann consists of various disadvantages, e.g. postoperative pain, swelling, flattening of the vestibulum and scar-tissue. Two alternative methods to close fresh oroantral fistulas without surgical intervention are described. By the use of prolamin occlusion gel or lyophilized dura these disadvantages can be avoided. Both techniques were successfully attempted on patients. The rate of failure is on both counts under 4%. Some indications limits must be strictly regarded. Both methods are really a good alternative to the usual operative procedure of Rehrmann and can easily be applied even on patients of great risk.

  14. Estudio microscópico de transiciones de fase en el fluido de esferas duras por simulación molecular

    OpenAIRE

    Sainz Ubide, Clara

    2016-01-01

    El objetivo principal de este TFG es el estudio de los mecanismos microscópicos de las transiciones de fases condensadas de un modelo fundamental de la materia como es el fluido de esferas duras. Para este fin se desarrollaron programas de simulación molecular de Monte Carlo y de dinámica molecular, así como códigos de evaluación y visualización de resultados. El estudio computacional de una sustancia requiere de tres elementos clave: un modelo descriptivo de dicha sustancia, una forma de ...

  15. Fatores associados com a duração do aleitamento materno Factors associated with duration of breastfeeding

    Directory of Open Access Journals (Sweden)

    Roberto G. Chaves

    2007-06-01

    Full Text Available OBJETIVOS: Determinar os índices de aleitamento materno exclusivo e complementado e identificar variáveis que interferem na prática da amamentação no município de Itaúna (MG. MÉTODOS: Estudo longitudinal realizado com 246 mulheres assistidas na maternidade do Hospital Manoel Gonçalves, no município de Itaúna (MG. O acompanhamento das mães e recém-nascidos foi realizado mensalmente nos primeiros 12 meses após o parto ou até a interrupção da amamentação. A análise da duração do aleitamento materno exclusivo e complementado foi realizada utilizando procedimentos de análise de sobrevivência. O efeito das co-variáveis sobre o tempo de aleitamento foi avaliado através do modelo de regressão de Cox. RESULTADOS: A prevalência de aleitamento materno exclusivo no sexto mês foi de 5,3%, e de aleitamento materno aos 12 meses, 33,7%. A mediana de aleitamento materno exclusivo foi de 40 dias, e a mediana de aleitamento materno, 237 dias. A análise multivariada mostrou associação negativa (p 9 consultas, uso de álcool ou tabaco, tempo da primeira mamada (> 6 horas e uso de chupeta. CONCLUSÕES: Os índices de aleitamento materno no município de Itaúna (MG estão muito abaixo daqueles preconizados pela Organização Mundial da Saúde. As principais variáveis relacionadas negativamente ao tempo de aleitamento materno exclusivo e complementado estão associadas à assistência materno-infantil, sendo, portanto, passíveis de intervenção.OBJECTIVES: To determine rates of exclusive breastfeeding and of complementary feeding and to identify variables that interfere with breastfeeding in the municipality of Itaúna, MG, Brazil. METHODS: A longitudinal study was undertaken enrolling 246 women who gave birth at the maternity unit of the Manoel Gonçalves Hospital, in Itaúna, MG. The mothers and their infants were seen monthly for the first 12 months after birth or until they stopped breastfeeding. Survival analysis procedures were

  16. Efeito do exercício prévio no ciclismo de curta duração

    Directory of Open Access Journals (Sweden)

    Renato Aparecido Corrêa Caritá

    2014-04-01

    Full Text Available INTRODUÇÃO: O exercício prévio tem importantes implicações na preparação de atletas antes de competições. OBJETIVO: Analisar o efeito de um exercício prévio realizado no domínio pesado no pico de torque (PTORQUE medido após exercício severo. MÉTODOS: Participaram deste estudo 14 homens ativos (idade: 26 ± 4 anos, VO2max: 44 ± 6 mLO2.min-1.kg-1 que realizaram sete testes em dias diferentes: a teste progressivo de rampa para determinação do VO2max e da potência pico; b quatro testes de carga constante para determinação da potência crítica, capacidade de trabalho anaeróbio e potência correspondente ao tempo de exaustão de 3 min (PTLim3min e; c dois testes de carga constante de 2 min na PTLim3min seguidos por um sprint all out de 10 s, a fim de medir o PTORQUE. Este último protocolo foi realizado com (EP e sem (CON a realização de um exercício prévio pesado. RESULTADOS: O PTORQUE foi significantemente maior após o EP (101 ± 30 Nm em relação à condição CON (95 ± 23 Nm. O tempo da resposta médio (TRM do VO2 foi significantemente menor após o EP (24 ± 7 s em relação à condição CON (32 ± 10 s. A amplitude primária do VO2 aumentou significantemente após o EP (2598 ± 421 mLO2.min-1 em relação à condição CON (2184 ± 246 mLO2.min-1. O déficit de O2 foi significantemente menor após o exercício prévio (980 ± 432 mLO2 em relação à condição CON (1273 ± 398 mLO2. Houve correlação significante entre a variação do déficit de O2 com a do PTORQUE (r = 0,53 e da variação do TRM com a do PTORQUE (r = 0,53. CONCLUSÃO: Pode-se concluir que o PTORQUE é maior após exercício aeróbio de curta duração precedido do EP. Deste modo, esta estratégia pode ser interessante como preparação para algumas competições esportivas.

  17. Meninges of the brain (image)

    Science.gov (United States)

    ... by 3 connective tissue layers collectively called the meninges. Consisting of the pia mater (closest to the ... the dura mater (farthest from the CNS), the meninges also support blood vessels and contain cerebrospinal fluid. ...

  18. Meninges of the spine (image)

    Science.gov (United States)

    ... by 3 connective tissue layers collectively called the meninges. Consisting of the pia mater (closest to the ... the dura mater (farthest from the CNS), the meninges also support blood vessels and contain cerebrospinal fluid. ...

  19. Development and validation of a bi-directional allele-specific PCR tool for differentiation in nurseries of dura, tenera and pisifera oil palms

    Directory of Open Access Journals (Sweden)

    Paola A. Reyes

    2015-04-01

    Full Text Available Oil palm (Elaeis guineensis Jacq. fruits are classified by shell thickness into three types: dura, pisifera, and tenera, the last one being the product of a dura × pisifera cross. The palm oil industry relies on the use of high-yield tenera plant material for production; however, it is usually generated with female infertile pisifera, so early identification of this trait is very important to oil production and breeding programs. Recently, the mapping and sequencing of the SHELL gene, which is responsible for endocarp formation in oil palms, made it possible to identify two mutations (type SNP, single nucleotide polymorphism that affect its function and that are useful to developing molecular markers for predicting shell thickness. The aim of this study was to standardize PCR-based methodologies in order to detect the SNP observed in codon 30 and validate it under our E. guineensis biological collections. We achieved the differentiation of SHELL alleles with both allele specific PCR and CAPS with the restriction enzyme HindIII in homozygous and heterozygous plants that contained the described mutation, and the prediction was correlated with the phenotype observed in oil palm fruits. These methodologies facilitated the discrimination of plants by fruit type in nursery and pre-nursery stages 24 months before production started, thereby reducing the time and area used in oil palm breeding programs.

  20. β2-agonista de longa duração na doença pulmonar obstrutiva crônica (DPOC

    Directory of Open Access Journals (Sweden)

    CAMPOS LUIZ EDUARDO MENDES

    2000-01-01

    Full Text Available No paciente com DPOC, os β2-agonistas de longa duração são capazes de produzir broncodilatação de intensidade semelhante à dos anticolinérgicos, mas, devido a sua propriedade lipofílica, a ação se prolonga por um período até 12 horas após a sua administração. Estudos comparativos entre salmeterol e formoterol sugerem eqüipotência entre 50mcg de salmeterol e 24 ou 12mcg de formoterol quando este é administrado respectivamente através do aerossol dosimetrado ou turbuhaler. É preciso considerar o tipo de inalador para se estabelecer a eqüipotência entre os dois agentes. Até mesmo pacientes com DPOC e cardiopatia associada podem fazer uso dos β2-agonistas de longa duração com segurança. O salmeterol, por ser agonista parcial, é mais seguro nesses casos de maior risco. A terapia broncodilatadora escalonada na DPOC pode ser revista. Brometo de tiotrópio é um novo anticolinérgico cuja ação pode se prolongar por mais de 1-3 dias e talvez seja o novo broncodilatador mais promissor na DPOC

  1. Efeitos agudos de levosimendana e dobutamina na duração do QRS em Pacientes com insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Osman Can Yontar

    2010-12-01

    Full Text Available FUNDAMENTO: A levosimendana é um novo agente inotrópico que aumenta a contratilidade cardíaca sem aumentar a captação celular de cálcio, de forma a não causar sobrecarga de cálcio e arritmias relacionadas. Em pacientes com insuficiência cardíaca (IC, a duração prolongada do QRS está associada com um aumento no risco de mortalidade e morte súbita cardíaca. Mudanças estruturais no ventrículo esquerdo podem levar à contração assíncrona, causando atraso de condução e um QRS prolongado no ECG de superfície. OBJETIVO: O objetivo do presente estudo foi comparar os efeitos agudos de levosimendana e dobutamina na duração do QRS em pacientes com IC grave e ritmo sinusal. MÉTODOS: 60 pacientes consecutivos com IC isquêmica foram incluídos no estudo e randomizados em dois grupos para infusão de levosimendana (n=37 ou dobutamina (n=23. 67,2 % eram homens; a média da idade era 66,4 ± 9,2 anos para todos os pacientes. A duração basal do QRS nos grupos levosimendana e dobutamina foi 120,44 ± 23,82 ms vs 116,59 ± 13,80 ms respectivamente. A fração de ejeção do ventrículo esquerdo (FEVE estava diminuída em ambos os grupos (23,15 ± 8,3 vs 24,56 ± 7,5%. RESULTADOS: No grupo levosimendana, a duração do QRS diminuiu do valor basal para 116,47 ± 24,56 ms (p=0,006, enquanto não houve diferença significante no grupo dobutamina (p=0,605. Ambos os medicamentos causaram um aumento na FEVE, mas este foi significante apenas no grupo levosimendana (27,95 ± 8,9% p=0,003 vs 26,67 ± 7,6%, p=0,315. CONCLUSÃO: O estudo sugere que a administração de levosimendana, mas não de dobutamina, encurta a duração do QRS no ECG de superfície, possivelmente por causar uma contração coletiva nas fibras do músculo do ventrículo esquerdo. A base molecular desse efeito ainda precisa ser esclarecida.

  2. The dura gide to annulus fibrosus closurement%人工生物膜修复椎间盘纤维环的研究

    Institute of Scientific and Technical Information of China (English)

    丁文元; 申勇; 郭金库; 贺延雷; 吴海龙; 曹来震; 李鹏飞

    2010-01-01

    Objective To evaluate the repair efficiency of dura gide to intervertebral disc annulus fibrosus defect. Methods Totallly 24 lumbar intervertebral discs of 8 sheep underwent one of the following 3 methods: (1) the disc annulus fibrosus was exposed through retroperitoneal approach without any farther procedure; (2) the disc annulus fibrosus was exposed and a defect was made, and then the defect was repaired with dura gide; (3) the disc annulus fibrosus was exposed and a defect was made as control. At the 12th week after surgery, 15 discs of 5 sheep underwent pressure-volume testing to assess the competency of the annulus fibrosus. MRI images and decalcified histology were performed on the remaining 9 discs of 3sheep. Results At the 12th week, the mean max-pressure in expose-only, excise-only and dura gide-reparied group was (4. 92 ±0. 17), (2. 48 ±0.39) and (3.76 ± 1.56) MPa, respectively. Both the competency in excised-only and dura gide-repaired groups was lower than in exposed-only group. The competency in dura gide-repaired groups was higher than in excise-only group ( P < 0. 05 ). MRI images and histology indicated that dura gide-repaired specimens were integrated well with the disc annulus fibrosus collagen.Conclusion There was a repair efficiency of dura gide to intervertebral disc annulus fibrosus defect. The mean competency recovery rate was 76.4%.%目的 用不同方法处理椎间盘纤维环,观察人工生物膜对椎间盘纤维环缺损的修复作用.方法 成年山羊8只,雌雄各4只,对每只羊的腰椎(腰2/3、腰3/4、腰4/5)椎间盘纤维环进行随机处理,处理方法包括:(1)暴露出椎间盘纤维环,不作任何处理;(2)暴露出椎间盘纤维环后,将其切开,用人下生物膜填充缺口;(3)暴露出椎间盘纤维环,尖刀将其切开,作为对照组.12周后,通过生物力学测试、核磁共振(MRI)及脱钙病理切片染色观察椎间盘纤维环的修复效果.结果 12周后,测试纤维环承受最

  3. Uso da hidrocortisona no tratamento e na prevenção da cefaléia pós-punção da dura-máter: relato de casos Uso de la hidrocortisona en el tratamiento y en la prevención de la cefalea después-punción de la dura-máter: relato de casos Hydrocortisone treatment and prevent post-dural puncture headache: case reports

    OpenAIRE

    José Francisco Nunes Pereira das Neves; Vinícius La Rocca Vieira; Rodrigo Machado Saldanha; Francisco de Assis Duarte Vieira; Michele Coutinho Neto; Marcos Gonçalves Magalhães; Mariana Moraes Pereira das Neves; Fernando de Paiva Araújo

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: A cefaléia pós-punção da dura-máter é a complicação mais freqüente após a raquianestesia ou a sua perfuração acidental durante tentativa de bloqueio peridural. O objetivo deste relato é descrever o uso da hidrocortisona no tratamento e na prevenção da cefaléia pós-punção da dura-máter (CPPD). RELATO DOS CASOS: São relatados três casos em que a hidrocortisona foi utilizada no tratamento e na prevenção da cefaléia pós-punção da dura-máter. O primeiro foi de uma pacien...

  4. Duração do onset vocálico da fala fluente de gagos Voice onset duration of stutterers' fluent speech

    Directory of Open Access Journals (Sweden)

    Cláudia Fassin Arcuri

    2010-01-01

    Full Text Available OBJETIVO: Comparar a duração da emissão da fala fluente de adultos com diferentes graus de gagueira em tarefa de repetição de frases. MÉTODOS: Seis adultos gagos, com grau de severidade variando de leve a severo, foram pareados com indivíduos sem nenhuma alteração de linguagem. O corpus foi composto pelas palavras "cavalo", "pipoca" e " tapete", inseridas em frases-veículo "Digo......baixinho". As frases foram emitidas pela pesquisadora e repetidas três vezes pelos indivíduos. A fala foi gravada diretamente em computador, tendo sido desconsideradas as emissões disfluentes. Posteriormente, foram realizadas as medidas de duração acústica das amostras, através do programa Praat 4.3. As frases foram divididas em segmentos delimitados por dois onsets vocálicos consecutivos. Os dados foram tabulados e analisados estatisticamente através do Teste-t e da ANOVA (Analysis of variance. RESULTADOS: Os gagos levaram mais tempo para emitir todas as unidades estudadas, com exceção da unidade [ib]. Na comparação entre os diferentes graus de severidade da gagueira, verificou-se que os gagos leves e moderados apresentam medidas de duração semelhantes e diferentes da dos gagos severos. CONCLUSÃO: Os parâmetros acústicos de duração delimitados pela medida dos onset vocálicos demonstraram que os gagos diferem dos não-gagos, além destas medidas diferenciarem os graus de severidade da gagueira.PURPOSE: To compare utterance duration of fluent speech of adults with different degrees of stuttering on a phrase repetition task. METHODS: Six adult stutterers, with severity degrees varying from mild to severe, were matched to individuals with no communication problems. The corpus was constituted by the words "horse", "popcorn" and "carpet" introduced into the vehicle-phrase "I say......quietly". Each phrase was uttered by the researcher and repeated aloud three times by the participants. The speech sample was recorded on a computer, and

  5. Duração do sono em adolescentes de diferentes níveis socioeconômicos Sleep duration in adolescents of different socioeconomic status

    Directory of Open Access Journals (Sweden)

    Maria Perpeto Socorro Leite Bernardo

    2009-01-01

    Full Text Available OBJETIVO: Investigar a duração de sono na adolescência em diferentes níveis socioeconômicos. MÉTODO: Foram investigados 863 adolescentes de 10 a 19 anos em duas escolas de São Paulo, SP, Brasil. As coletas foram realizadas por meio de questionários para identificação de informações sobre os hábitos de sono e nível socioeconômico. RESULTADOS: A duração média de sono nos dias da semana foi de 8,83(1,87 horas e a prevalência de adolescentes com duração de sono de oito ou menos horas diárias foi de 39,0% nos dias com aula. Adolescentes da classe baixa apresentaram menor duração do sono (p = 0,043. Na análise ajustada, a idade, o nível socioeconômico e o hábito de tirar a sesta foram os principais fatores associados a poucas horas de sono. Os participantes de 18 a 19 anos apresentaram maior prevalência de poucas horas de sono em comparação aos de 10 a 11 anos (PR = 4,78; CI95%: 1,98-11,53, assim como os adolescentes da classe alta em comparação com a classe baixa (PR = 1,48; CI95%: 1,20-1,83. CONCLUSÃO: Os resultados mostraram associações entre o nível socioeconômico e os hábitos de sono de adolescentes.OBJECTIVE: To investigate the sleep duration in adolescents of different socioeconomic status. METHOD: We investigated 863 adolescents from 10 to 19 years in two schools in São Paulo, SP, Brazil. Sleep habits data and socioeconomic status were obtained by questionnaires. RESULTS: Mean sleep duration on days of the week was 8.83(1.87 hours and the prevalence of adolescents with eight or fewer hours/day was 39.0% on school days (p = 0.043. On adjusted analysis, age, socioeconomic status and taking a nap habit were the main factors associated with few hours of sleep. Older students (aged 18 to 19 years showed higher prevalence of few hours of sleep when compared to younger students (10 to 11 years (RP = 4.78; IC95%: 1.98-11.53, as well as for upper class adolescents when compared to those with lower socioeconomic

  6. Raquianestesia com lidocaína a 2% pura em cirurgias ortopédicas de curta duração: estudo em 250 pacientes

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    Luiz Eduardo Imbelloni

    2002-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Um dos mais importantes fatores que afeta o nível da analgesia após administração subaracnóidea de anestésicos locais é sua densidade em relação à densidade do líquido cefalorraquidiano. O objetivo deste estudo foi avaliar o inicio, a duração e a dispersão cefálica da lidocaína a 2% na raquianestesia após injeção em decúbito lateral em pacientes ortopédicos de cirurgia de curta duração. MÉTODO: Participaram do estudo 250 pacientes com idades entre 15 e 78 anos, estado físico ASA I e II escalados para diversos tipos de cirurgias ortopédicas, submetidos à raquianestesia com dose fixa de 3 ml de lidocaína a 2% (60 mg. Foram avaliados os seguintes parâmetros: latência, bloqueio motor, duração dos efeitos, dispersão cefálica da analgesia e alterações cardiocirculatórias. RESULTADOS: O tempo médio para a instalação da analgesia foi de 1,47 ± 0,75 min. Não houve correlação entre a idade e o tempo de latência. Ocorreu incidência de falhas em 1,75% dos pacientes. Houve diferença significativa entre os grupos para atingir o bloqueio motor completo, sendo mais rápido nos grupos mais idosos. O bloqueio motor completo ocorreu em 93% dos pacientes. A duração do bloqueio sensitivo foi de 102,32 ± 15,45 minutos e do bloqueio motor de 106,48 ± 16,48 minutos. Hipotensão arterial ocorreu em 5,6% e bradicardia em 1,2%. Observou-se três casos de sintomas neurológicos transitórios (1,2% todos submetidos à videoartroscopia. CONCLUSÕES: Três ml de lidocaína a 2% isobárica proporcionam uma grande variação na dispersão da analgesia, com uma grande estabilidade cardiocirculatória e baixa incidência de SNT. A lidocaína a 2% pura é uma nova opção para cirurgias com tempo cirúrgico em torno de uma hora, podendo ser útil quando se pretende usar a raquianestesia em cirurgia ambulatorial.

  7. Ocular pharmacokinetics of bimatoprost formulated in DuraSite compared to bimatoprost 0.03% ophthalmic solution in pigmented rabbit eyes

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    Shafiee A

    2013-07-01

    Full Text Available Afshin Shafiee,1 Lyle M Bowman,2 Eddie Hou,2 Kamran Hosseini1,3 1Preclinical, 2Development, 3Clinical, InSite Vision, Alameda, CA, USA Purpose: To compare the aqueous humor (AH and iris-ciliary body (ICB concentration of bimatoprost in rabbit eyes treated with ISV-215 (0.03% bimatoprost formulated in DuraSite with the marketed product bimatoprost 0.03% ophthalmic solution. Methods: The left eye of rabbits received a single topical instillation of either ISV-215 (n = 32 eyes or bimatoprost 0.03% (n = 32 eyes. At predetermined time points, levels of bimatoprost and bimatoprost acid in the AH and the ICB were quantified by HPLC-MS/MS. Results: Both bimatoprost and bimatoprost acid were detected in the AH and the ICB within 15 minutes of dosing. Bimatoprost acid concentrations in both compartments were markedly higher than bimatoprost. There was a statistically significant (P < 0.01 increase in the concentration of the prodrug in the AH and its acid form in the ICB in animals treated with ISV-215 compared to bimatoprost 0.03%. In the ISV-215-treated rabbit eyes, the highest concentrations of bimatoprost and bimatoprost acid were in the ICB and AH, respectively, while in the bimatoprost 0.03%-treated eyes, no differences in the drug content of the selected ocular tissues were observed. Conclusions: Bimatoprost 0.03% formulated in DuraSite has superior ocular distribution and area under the curve compared to bimatoprost 0.03% in rabbit eyes. This improvement in the pharmacokinetic parameters of ISV-215 may provide us with a better platform to optimize a bimatoprost formulation that offers the same degree of efficacy in lowering intraocular pressure and improved therapeutic index in glaucomatous patients by lessening the ocular side effects associated with long-term use of topical prostaglandin F2α analogs. Keywords: drug delivery, intraocular pressure, glaucoma, aqueous humor, prostaglandin (PGF2α analogs

  8. Alma mater eksponeerib / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2004-01-01

    Tiit Pääsukese "Maalid" Tartu Ülikooli Y-galeriis 2.-21. III, galeriist (galerist Margus Kiis). Näitus "Põletatud savi - antiigist tänapäevani" TÜ kunstimuuseumis (Berliini Antikensammlungi antiikvaasid, 17 eesti keraamiku antiigiteemalised taiesed) kuni 30. III, kuraatorid Inge Kukk, Airi Ligi, kujundaja Silver Vahtre

  9. Alma mater eksponeerib / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2004-01-01

    Tiit Pääsukese "Maalid" Tartu Ülikooli Y-galeriis 2.-21. III, galeriist (galerist Margus Kiis). Näitus "Põletatud savi - antiigist tänapäevani" TÜ kunstimuuseumis (Berliini Antikensammlungi antiikvaasid, 17 eesti keraamiku antiigiteemalised taiesed) kuni 30. III, kuraatorid Inge Kukk, Airi Ligi, kujundaja Silver Vahtre

  10. Intensidade e duração dos esforços físicos em aulas de Educação Física

    Directory of Open Access Journals (Sweden)

    Marina Marques Kremer

    2012-04-01

    Full Text Available OBJETIVO: Avaliar a intensidade e a duração dos esforços físicos em aulas de Educação Física no ensino fundamental e médio. MÉTODOS: Estudo transversal de base escolar por meio de observação de 218 aulas de Educação Física, incluindo um total de 272 estudantes (avaliados três vezes cada um. O estudo foi realizado em Pelotas, RS, de agosto a setembro de 2009. Para a intensidade dos esforços, foram utilizados acelerômetros e adotados os pontos de corte (em counts por minuto: atividades sedentárias (0 a 100, leves (101 a 2.000, moderadas (2.001 a 4.999, vigorosas (5.000 a 7.999 e muito vigorosas (> 8.000. RESULTADOS: O tempo médio de duração das aulas foi de 35,6 minutos (dp 6,0. A proporção média de tempo das aulas em atividades físicas de intensidade moderada a vigorosa foi de 32,7% (dp 25,2. Os meninos (44,1% envolveram-se significativamente mais em atividades físicas moderadas a vigorosas do que as meninas (21,0%; p < 0,01. Estudantes que se envolvem em atividade física fora das aulas tiveram maior participação em atividades físicas moderadas a vigorosas nas aulas de Educação Física. CONCLUSÕES: Além de o tempo da aula de Educação Física ser reduzido, os estudantes praticam atividades físicas de intensidade moderada a vigorosa um terço da aula, com pouca contribuição significativa para o nível de atividade física dos estudantes.

  11. A duração do exercício determina a magnitude e a duração da hipotensão pós-exercício Exercise duration determines the magnitude and duration of post-exercise hypotension

    Directory of Open Access Journals (Sweden)

    Cláudia Lúcia de Moraes Forjaz

    1998-02-01

    Full Text Available OBJETIVO: Considerando-se que a duração do exercício físico possa influenciar a hipotensão pós-exercício, testamos a hipótese de que o exercício submáximo mais prolongado provoca queda pressórica de maior magnitude e duração que o exercício mais curto.MÉTODOS: Protocolo experimental - 10 indivíduos realizaram duas sessões de exercício (25 e 45min no cicloergômetro em 50%VO2 pico. Protocolo controle - 12 indivíduos permaneceram em repouso por 45min. A pressão arterial (PA foi aferida antes (20min e após (90min o exercício ou o repouso. RESULTADOS: Protocolo experimental - a PA sistólica diminuiu significantemente pós-exercício e essa queda foi maior e mais prolongada após 45min de exercício. A PA média e diastólica diminuíram significantemente pós-exercício e foram significantemente menores na sessão de 45min. Protocolo controle - a PA não se alterou durante a sessão controle. CONCLUSÃO: O exercício físico de maior duração provoca hipotensão pós-exercício maior e mais prolongada.PURPOSE: Considering that exercise duration may play a role in post-exercise hypotension, we tested the hypothesis that a prolonged submaximal exercise would lead to a greater and longer blood pressure fall after exercise than a shorter exercise bout. METHODS: Experimental protocol - 10 subjects were submitted to two cycle ergometer exercise trials (25 and 45min at 50% of VO2 peak. Control protocol - 12 subjects rested in the sitting position for 45min. Blood pressure (BP was measured before (20min and after (90min rest or exercise bouts. RESULTS: Systolic BP decreased significantly after exercise and this reduction was greater and lasted longer after 45min of exercise. Mean and diastolic BP decreased after exercise and they were significantly lower during the 45min session. Control protocol - no change in BP was observed after resting condition. CONCLUSION: A longer exercise bout leads to a greater and longer post

  12. De brava a dura. La policía de la provincia de Buenos Aires durante la primera mitad del siglo XX

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    Osvaldo Barreneche

    2010-12-01

    Full Text Available Este artículo analiza la transformación institucional de la policía de la provincia de Buenos Aires durante la primera mitad del siglo XX. Se estudia primero la etapa que va desde la separación con la policía de la Capital (década de 1880 hasta finales de los años veinte, durante la cual circula un repertorio de medidas reformistas de la policía que serviría de base para la época siguiente. Luego, se divide la transformación policial bonaerense en tres etapas: 1 la década del treinta, donde se ponen las bases para importantes cambios de la agencia policial; 2 la revolución de junio de 1943 más el período peronista, en el cual se llevó a cabo una profunda reestructuración policial; y 3 el período de la revolución libertadora, tratado en este trabajo a modo de conclusión. En conjunto, el artículo plantea el tránsito de una policía brava a una dura , que formuló sus propios objetivos institucionales dentro de un esquema de alineamiento con el poder político-militar de entonces.

  13. A arte de conjugar tempo e espaço: Fernand Braudel, a geo-história e a longa duração

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    Guilherme Ribeiro

    2015-04-01

    Full Text Available Apresenta o surgimento do conceito de geo-história, elaborado pelo historiador francês Fernand Braudel no texto “Géohistoire: la société, l’espace et le temps” durante sua prisão pelos alemães em meio à Segunda Guerra Mundial. Tal conceito expressa a crítica de Braudel às fronteiras disciplinares, bem como a relevância da geografia na construção de seu método histórico de longa duração. Duplamente inspirada pelo estudo das relações entre sociedade e meio ambiente oriundo dos geógrafos franceses e pelo trinômio espaço-economia-sociedade proveniente dos geógrafos alemães, a geo-história braudeliana revela uma abordagem muito mais consistente e complexa que as teses de Lucien Febvre contidas no difundidoA terra e a evolução humana: introdução geográfica à história.

  14. 论杜拉斯创作中的重复叙述%On Repeated Narration in the Creation of Marguerite Duras

    Institute of Scientific and Technical Information of China (English)

    王琼

    2014-01-01

    In Marguerite Duras'works, it is easy for us to find her recollections upon real life through figures, background and feelings, and similar emotional tone in different works, resulting in the repeated plots and figures in the course of story narra-tion.As a matter of fact, this repeated creation originates from her unique life experience and creative mentality, which grants the connotation of the story a power of flexible tension.%杜拉斯在作品的人物、背景、情感之中常常杂糅了对现实生活的回忆,在她不同作品中可以发现她流露着相同的情感基调,体现在故事的叙述上就是一再出现重复的情节和人物。这种创作的重复性源于杜拉斯独特的生活体验和创作心理,也使小说的内涵更富弹性张力。

  15. A longa duração e as estruturas temporais em Fernand Braudel: de sua tese O Mediterrâneo e o Mundo Mediterrânico na Época de Felipe II até o artigo História e Ciências Sociais : a longa duração (1949-1958)

    OpenAIRE

    Cracco, Rodrigo Bianchini [UNESP

    2009-01-01

    Fernand Braudel defende a pesquisa histórica que prioriza a longa duração. Os próprios fundadores da revista dos Annales já pensavam a história a partir de longos períodos, contrapondo-se à história política dos séculos XVIII e XIX, ainda que Fernand Braudel afirme que a história política não é exclusivamente factual, nem condenada a sê-lo. Para entendermos como Fernand Braudel chega a esta posição é necessário refletir sobre as influências que o levaram a tal, dentre as quais e, principalmen...

  16. ¿CUÁNTO DURA UNA INVERSIÓN DEL CAMPO MAGNÉTICO TERRESTRE? Nuevos datos de la última inversión del campo magnético terrestre

    OpenAIRE

    Sagnotti, L.

    2014-01-01

    CUÁNTO DURA UNA INVERSIÓN DEL CAMPO MAGNÉTICO TERRESTRE? El campo magnético terrestre (o campo geomagnético) está generado por el movimiento complejo que tiene lugar en el núcleo externo de la Tierra. En su mayor parte, este campo es asimilable al que generaría una barra de imán situada en el centro del planeta.

  17. 电刺激大鼠上矢状窦区硬脑膜后血浆与脑组织中降钙素基因相关肽、P物质和前列腺素 E2释放差异%Release difference of calcitonin gene-related peptide,substance P and prostaglandin E2 in orbital venous plexus plasma and brain tissues from rats with dura mater of superior sagittal sinus following electrical stimulation

    Institute of Scientific and Technical Information of China (English)

    陈健; 吕新勇; 孙晓萍; 陈春苗; 周军; 王振中; 萧伟

    2014-01-01

    OBJECTIVE Toexplorethefeasibilityofpreparingamigrainemodelusingratdura materofsuperiorsagittalsinusinfollowingelectricalstimulation.METHODS MaleSDratswereexposed to 1 h electrical stimulation after brain electrode implantation,at 3 V,6 Hz,and a pulse of 0.25 ms.At 0, 1 5,30 min,and 1 h,orbital blood and brain tissue were taken.The content of calcitonin gene-related peptide (CGRP),substance P and prostaglandin E2 (PGE2 )in the plas ma and brain tissue was detec-tedbyradioimmunoassay.RESULTS ThebraintissuecontentofCGRP,substancePandPGE2in the sham group and normal group was not significantly different.CGRP,substance P and PGE2 in brain tissue of model group were 3.41 ±0.93,1 .80 ±0.64,3.41 ±0.93 and (1 .80 ±0.64)ng·g -1 respec-tively,significantly different from sham group(P<0.05).At different time points,the content of CGRP, substance P and PGE2 in plasma orbital venous plexus showed no significant difference between sham groupandmodelgroup.CONCLUSION ThereleaseofCGRP,PGE2andsubstancePinbraintissue is significantly different fro m that of plas ma after electrical sti mulation.The results suggest that a model of migraine can be constructed by electrical stimulation.%目的:探讨电刺激大鼠上矢状窦区硬脑膜制备偏头痛模型的可行性。方法雄性SD 大鼠,脑部电极植入术后行电压3 V、频率6 Hz、脉宽0.25 ms、时间1 h电刺激,并于刺激0,15和30 min和1 h进行眼眶采血,采血后取脑组织。采用放射免疫法检测血浆和脑组织中降钙素基因相关肽(CGRP)、P物质和前列腺素E2(PGE2)含量。结果手术对照组与正常对照组大鼠脑组织中 CGRP 含量、P 物质含量和PGE2含量为均无显著性差异;模型组大鼠脑组织中CGRP、P物质和 PGE2分别为3.41±0.93,1.80±0.64和(5.17±0.69)ng·g -1,与手术对照组大鼠相比均有显著性差异(P<0.05)。各时间点手术对照组与模型组大鼠外周静脉血浆中CGRP、P物质和PGE2含量无显著性差异。结论电刺激大鼠上矢状窦区硬脑膜后,脑组织中CGRP、PGE2和P物质水平与外周静脉血中显著不同,表明可采用本方法制备偏头痛模型。

  18. Duration of pairing and use of allosperm in Biomphalaria glabrata (Gastropoda: Planorbidae Duração do acasalamento e uso do aloesperma em Biomphalaria glabrata (Gastropode: Planorbidae

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    Marc Vianey-Liaud

    1989-03-01

    Full Text Available Virgin homozygous black pigmented and albino Biomphalaria glabrata are paired during a period varying from 1 to 20 days. The rate of cross-fertilized parents is statistically similar for the various lengths of pairing. As a whole, nearly 80% of the albino snails produce a pigmented progeny. This production begins as soon as the snails are mated and continues after their separation. To measure the actual use of the allosperm, its use during the postmating period must be added to the length of mating. So, it appears that the real use of the allosperm is statistically constant (mean slightly inferior to 8 weeks and not related to the length of the previous pairing.Espécimes virgens de Biomphalaria glabrata (um melâncio e um albino são acasalados durante um período variável de 1 a 20 dias. A proporção de espécimes parentais albinos fecundados por cruzamento é semelhante estatisticamente para os diversos períodos de acasalamento. Em conjunto, cerca de 80% dos albinos produziram descendência pigmentada. Essa produção começa assim que os moluscos são acasalados e continua depois que são separados. Para medir a utilização real do aloesperma, sua utilização durante o período de pós-acasalamento. Parece, assim, que a utilização real do aloesperma é estatisticamente constante (média ligeiramente inferior a oito semanas e não relacionada a duração do acasalamento anterior.

  19. Secagem e formação de sementes duras em mucuna-preta Drying and hard seeds formation in velvet bean

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    João Nakagawa

    2005-01-01

    Full Text Available A mucuna-preta, leguminosa empregada como adubação verde e forrageira, produz sementes com dormência causada pela impermeabilidade do tegumento à água (dureza. O objetivo do trabalho foi estudar as relações entre a secagem das sementes no interior das vagens e a ocorrência desse fenômeno. Para tanto, nas colheitas realizadas semanalmente entre 40 e 89 dias após o florescimento, foram obtidas sementes de vagens submetidas ou não à secagem. Foram realizadas determinações de teor de água das sementes na colheita, coloração nas vagens e nas sementes no momento da colheita, condutividade elétrica, germinação e presença de sementes duras. A secagem das sementes nas vagens, separadas da planta-mãe, favorece o surgimento da dureza; essa ocorrência, contudo, é atenuada com o retardamento da referida separação.The velvet bean [Mucuna aterrima (Piper et Tracy Holland] is a legume used for green manure and as forage. Its seeds have dormancy caused by coating impermeable to water. The purpose of this work was to study relations between seed drying in intact pod and hardness occurrence. Pods were harvested weekly between 40 and 89 days after flowering. From these pods, subjected or not to dry, seeds were evaluated regarding moisture content at harvest, color of pods and seeds at harvesting times, electrical conductivity of exudate solutions, germination and hard seeds presence. Seed drying in intact pods, separated from plants, is favors the development of hardness. However this occurrence decreases with a late separation from plants.

  20. Percepção subjetiva de esforço como marcadora da duração tolerável de exercício

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    Fabiano Aparecido Pinheiro

    2014-06-01

    Full Text Available A percepção subjetiva de esforço (PSE foi sugerida, originalmente, como uma marcadora da intensidade do exercício, pois ela responderia às alterações nos sistemas cardiopulmonar e metabólico, principalmente às alterações da FC e concentrações de lactato sanguíneo durante o exercício. Entretanto, esta interpretação não se alinha às respostas fisiológicas observadas em diferentes intensidades de exercícios, pois a PSE aumenta de forma linear, mesmo em intensidades em que ocorre um estado de equilíbrio fisiológico. No presente artigo de revisão, discutimos que este desalinhamento entre teoria e resultados experimentais poderáestar ligado aos mecanismos de geração e modulação da PSE durante o exercício. Neste caso, o mecanismo de geração da PSE pelo sistema nervoso central poderá responder basicamente à intensidade do exercício, enquanto as respostas fisiológicas periféricas poderão modular a PSE ao longo do exercício, indicando as condições fisiológicas quando da realização do exercício. Desta forma, a PSE poderia ser marcadora da duração tolerável do exercício executado numa determinada intensidade.

  1. Métodos de optimización para el problema de ruteo de vehículos con inventarios y ventanas de tiempo duras

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    Eliseo Pérez Kaligari

    2015-10-01

    Full Text Available El problema estudiado considera las decisiones de ruteo de vehículos con inventarios y restricciones de ventanas de tiempo duras (IRPTW en una cadena de abastecimiento compuesta por un depósito y múltiples minoristas. Se asume un horizonte de planeación discreto y finito en donde las decisiones por optimizar son: las cantidades a aprovisionar a los minoristas y, simultáneamente, la secuencia de minoristas a visitar en cada periodo de tiempo. El sistema cuenta con un sólo vehículo de capacidad limitada, restricciones de capacidad de almacenamiento de los minoristas, y tasa de producción limitada del depósito. Se requiere satisfacer la demanda que tienen los minoristas. Se asume que los minoristas tienen demanda determinística y no homogénea. Se propone una formulación matemática basada en programación entera mixta y se estudia el impacto que tiene la configuración de las ventanas de tiempo sobre las decisiones de ruteo de vehículos con inventarios, a través de dos métodos de optimización. El primer método optimiza las decisiones de forma simultánea, mientras que el segundo método propuesto considera las decisiones de forma secuencial, lo que lo convierte en un método heurístico. Se presenta un estudio computacional con 80 instancias adaptadas de la literatura. Los resultados muestran que el método de optimización simultáneo tiene un desempeño mejor que el método heurístico de optimización secuencial generando ahorros potenciales en los costos logísticos de al menos 6%.

  2. In vitro somatic embryogenesis and plantlet regeneration from immature male inflorescence of adult dura and tenera palms of Elaeis guineensis (Jacq.).

    Science.gov (United States)

    Jayanthi, Madhavan; Susanthi, Bollarapu; Murali Mohan, Nandiganti; Mandal, Pranab Kumar

    2015-01-01

    We report here a method for plant regeneration through somatic embryogenesis from explants collected from immature male inflorescence of adult oil palm cultivated in India. Callus induction was successful from tissues of immature male inflorescence collected from both dura and tenera varieties of oil palm. A modified Y3 (Eeuwens) media supplemented with several additives and activated charcoal (3%) were used for the experiments. Out of four different auxin treatments, 4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid (picloram) produced maximum callus induction (82%) and it was not significantly different from 2,4-dichlorophenoxyacetic acid (2,4-D) and a combination of 2,4-D + picloram. The callus induction obtained with auxin α-naphthalene acetic acid was only 54% and it was significantly low as compared to the other treatments. Highest embryogenesis was obtained with a combination of 2,4-D + picloram (4.9%) followed by picloram (3.4%). Genotypic variation in response to the same auxins was observed both for callus induction and embryogenesis. Callus induction and embryogenesis ranged from 42 to 72% and 6.8 to 9.35%, respectively in tenera. The formation of embryogenic calli was marked by the appearance of white to yellowish globular or nodular structures which subsequently formed clear somatic embryos. Somatic embryogenesis was asynchronous and at one time we could find different stages of embryogenesis like the globular, torpedo and the cotyledonary stages. The somatic embryos when exposed to light in the same basal media along with 6-benzyladenine (18 µM), abscisic acid (3.78 µM) and gibberellic acid (5.78 µM) regenerated into plantlets. To the best of our knowledge this is the first report o f callus induction and somatic embryogenesis from immature male inflorescence of oil palm.

  3. Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura

    Directory of Open Access Journals (Sweden)

    Huang Dongyue

    2012-09-01

    Full Text Available Abstract Background Migraine and other headache disorders affect a large percentage of the population and cause debilitating pain. Activation and sensitization of the trigeminal primary afferent neurons innervating the dura and cerebral vessels is a crucial step in the “headache circuit”. Many dural afferent neurons respond to algesic and inflammatory agents. Given the clear role of the transient receptor potential (TRP family of channels in both sensing chemical stimulants and mediating inflammatory pain, we investigated the expression of TRP channels in dural afferent neurons. Methods We used two fluorescent tracers to retrogradely label dural afferent neurons in adult mice and quantified the abundance of peptidergic and non-peptidergic neuron populations using calcitonin gene-related peptide immunoreactivity (CGRP-ir and isolectin B4 (IB4 binding as markers, respectively. Using immunohistochemistry, we compared the expression of TRPV1 and TRPA1 channels in dural afferent neurons with the expression in total trigeminal ganglion (TG neurons. To examine the distribution of TRPM8 channels, we labeled dural afferent neurons in mice expressing farnesylated enhanced green fluorescent protein (EGFPf from a TRPM8 locus. We used nearest-neighbor measurement to predict the spatial association between dural afferent neurons and neurons expressing TRPA1 or TRPM8 channels in the TG. Results and conclusions We report that the size of dural afferent neurons is significantly larger than that of total TG neurons and facial skin afferents. Approximately 40% of dural afferent neurons exhibit IB4 binding. Surprisingly, the percentage of dural afferent neurons containing CGRP-ir is significantly lower than those of total TG neurons and facial skin afferents. Both TRPV1 and TRPA1 channels are expressed in dural afferent neurons. Furthermore, nearest-neighbor measurement indicates that TRPA1-expressing neurons are clustered around a subset of dural afferent

  4. Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura

    Science.gov (United States)

    2012-01-01

    Background Migraine and other headache disorders affect a large percentage of the population and cause debilitating pain. Activation and sensitization of the trigeminal primary afferent neurons innervating the dura and cerebral vessels is a crucial step in the “headache circuit”. Many dural afferent neurons respond to algesic and inflammatory agents. Given the clear role of the transient receptor potential (TRP) family of channels in both sensing chemical stimulants and mediating inflammatory pain, we investigated the expression of TRP channels in dural afferent neurons. Methods We used two fluorescent tracers to retrogradely label dural afferent neurons in adult mice and quantified the abundance of peptidergic and non-peptidergic neuron populations using calcitonin gene-related peptide immunoreactivity (CGRP-ir) and isolectin B4 (IB4) binding as markers, respectively. Using immunohistochemistry, we compared the expression of TRPV1 and TRPA1 channels in dural afferent neurons with the expression in total trigeminal ganglion (TG) neurons. To examine the distribution of TRPM8 channels, we labeled dural afferent neurons in mice expressing farnesylated enhanced green fluorescent protein (EGFPf) from a TRPM8 locus. We used nearest-neighbor measurement to predict the spatial association between dural afferent neurons and neurons expressing TRPA1 or TRPM8 channels in the TG. Results and conclusions We report that the size of dural afferent neurons is significantly larger than that of total TG neurons and facial skin afferents. Approximately 40% of dural afferent neurons exhibit IB4 binding. Surprisingly, the percentage of dural afferent neurons containing CGRP-ir is significantly lower than those of total TG neurons and facial skin afferents. Both TRPV1 and TRPA1 channels are expressed in dural afferent neurons. Furthermore, nearest-neighbor measurement indicates that TRPA1-expressing neurons are clustered around a subset of dural afferent neurons. Interestingly, TRPM

  5. Sono, trabalho e estudo: duração do sono em estudantes trabalhadores e não trabalhadores Sleep, work, and study: sleep duration in working and non-working students

    Directory of Open Access Journals (Sweden)

    Érico Felden Pereira

    2011-05-01

    Full Text Available Este estudo objetivou investigar a duração do sono e fatores associados em escolares trabalhadores e não trabalhadores. Foram coletadas informações sobre o padrão do ciclo vigília/sono de 863 adolescentes de 10 a 19 anos em escolas de São Paulo, Brasil. Análises ajustadas foram aplicadas para comparação da duração do sono entre trabalhadores e não trabalhadores. O porcentual de adolescentes trabalhadores foi de 18,4% e 52% dos jovens que trabalhavam apresentaram oito ou menos horas de sono. A prevalência de baixa duração do sono foi maior nos trabalhadores dos sexos masculino (p = 0,017 e feminino (p The aim of this study was to investigate the duration of sleep and associated factors in working and non-working students. Data were analyzed on the sleep-wake cycle in 863 teenage students in São Paulo, Brazil. Adjusted analyses were performed to compare sleep duration in working and non-working students. 18.4% of the group worked, and 52% of the working students slept eight hours or less per night. Prevalence of short sleep duration was higher in working students of both sexes (males, p = 0.017; females, p < 0.001. Working students showed short sleep duration in the analysis adjusted for socioeconomic status, but short sleep was more frequent in older adolescents (p = 0.004 and in lower (p = 0.001 and middle (p = 0.011 socioeconomic classes. Although more working students were in night school, in the model adjusted for gender and socioeconomic status, working students in afternoon courses showed higher prevalence of short sleep duration (PR = 2.53; 95%CI: 1.68-4.12.

  6. El Niño: ocorrência e duração dos veranicos do Estado de Minas Gerais El Niño: occurrence and duration of dry spells in the State of Minas Gerais - Brazil

    Directory of Open Access Journals (Sweden)

    Rosandro B. Minuzzi

    2005-09-01

    Full Text Available Com o objetivo de caracterizar o início do período chuvoso (IPC, a quantidade de chuvas durante o período chuvoso (PC e a ocorrência e duração dos veranicos em anos de ocorrência da fase quente do fenômeno climático El Niño-Oscilação Sul (ENOS, analisaram-se dados de precipitação pluvial de 123 localidades do Estado de Minas Gerais e as relações entre a duração dos períodos chuvosos (DPC e/ou os IPCs com os veranicos de duração de três a seis dias (A e de sete a dez dias (B, e os IPCs com os totais pluviométricos durante os PCs com os veranicos de classes A e B, respectivamente. Os resultados indicaram uma característica marcante do El Niño em ocasionar chuvas abaixo da média no nordeste do Estado e chuvas acima da média climática no sudoeste de Minas Gerais. As estiagens ao norte e nordeste do Estado corresponderam a períodos superiores a 15 dias e as chuvas acima da média, no sudoeste, foram melhor correlacionadas com os veranicos de duração de três a seis dias.Daily precipitation data from 123 locations of the State of Minas Gerais were analyzed to characterize the beginning of the rainy season (IPC, the amount of rainfall during the rainy season (PC and the occurrence and length of the dry spell in years associated to El Niño Southern Oscillation (ENSO. The relationship between the duration of rainy season (DPC, begining of the rainy period and the dry spells from three to six days (A; from seven to ten days (B and the IPC with the rainfall during the rainy periods with dry spells (A and (B were also studied. The results showed that ENSO is related to rainfall below historical average in the northeastern region of the State of Minas Gerais, and to rainfalls above the climatic average in the southwestern region. The duration of the dry spells in the northern and northeastern region of the state were higher than 15 days, and the rainfall above normal in the southwestern part of the state were better correlated

  7. Controle multivariado de processos em batelada com duração variável Multivariate statistical control of unsynchronized batch processes

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    Flávio S. Fogliatto

    2008-01-01

    Full Text Available Processos em batelada são utilizados em diversos setores industriais (por exemplo, na manufatura de alimentos e fármacos. Nesses processos, matérias-primas são carregadas em uma unidade de processamento e submetidas a uma série de transformações até a obtenção do produto final. O desempenho do processo é descrito por variáveis, monitoradas ao longo da batelada. Dados resultantes desses processos tendem a apresentar uma estrutura de correlação e autocorrelação significativa, sendo usualmente monitorados usando cartas de controle baseadas na análise de componentes principais (CCPs. Neste artigo, investiga-se o caso especial, bastante freqüente na prática, de bateladas com duração variável, as quais não podem ser diretamente monitoradas através das CCPs. Para tanto, propõe-se uma nova estratégia de controle multivariado da qualidade. No procedimento proposto, bateladas não são alinhadas ou time warped relativamente a suas trajetórias, mas completadas utilizando um esquema de fácil implementação prática. Desta forma, preserva-se toda a informação sobre a variabilidade ao longo do eixo do tempo nos perfis das variáveis de processo. O conjunto de dados completados é analisado utilizando o método Statis e o monitoramento do desempenho da batelada é realizado diretamente nos gráficos de planos fatoriais, a partir dos quais cartas de controle não-paramétricas são derivadas. Um exemplo utilizando dados simulados ilustra a proposta metodológica.Batch processes are widely used in several industrial sectors, such as food and pharmaceutical manufacturing. In a typical batch, raw materials are loaded in the processing unit and submitted to a series of transformations, yielding the final product. Process performance is described by variables which are monitored as the batch progresses. Data arising from such processes are likely to display a strong correlation-autocorrelation structure, and are usually monitored using

  8. Black, white and shades of grey: SUNCT or short-lasting chronic paroxysmal hemicrania? Preto, branco e tons de cinza: SUNCT ou hemicrania paroxística crônica de curta duração?

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    Yára Dadalti Fragoso

    2006-09-01

    Full Text Available AIM OF THE STUDY: To report a case of unilateral headache with two possibilities of diagnosis. METHOD: Case report. RESULTS: Patient with unilateral, intense, stabbing periocular headache with conjuntival injection and tearing. Although the duration of attacks was typical of SUNCT, there was complete remission of the pain with indomethacin, suggesting that this was a case of chronic paroxysmal hemicrania with unusually short attack duration. CONCLUSION: Therapeutic trials of indomethacin on younger patients presenting clinical diagnosis of SUNCT could be tried on a more regular basis.MOTIVO DO ESTUDO: Relatar um caso de cefaléia unilateral com duas possibilidades diagnósticas. MÉTODOS: Relato de caso. RESULTADOS: Paciente com cefaléia unilateral, intensa, em pontadas em região periocular, com congestão conjuntival e lacrimejamento. Embora a duração das crises fosse típica de SUNCT, houve remissão completa da dor com indometacina, sugerindo que se trate de um caso de hemicramia paroxística crônica com crises de duração atipicamente muito curta. CONCLUSÃO: Testes terapêuticos com indometacina em pacientes mais jovens com diagnóstico clínico de SUNCT poderiam ser tentados de forma mais regular.

  9. Analise das curvas de intensidade-duração-frequência para a cidade de Pelotas através de uma função de desagregação.

    Directory of Open Access Journals (Sweden)

    Eduarda Medran Rangel

    2017-02-01

    Full Text Available Este trabalho teve como objetivo a obtenção e comparação de duas curvas de intensidade-duração-frequência (IDF de precipitação para a cidade de Pelotas, RS, através de dois métodos e uma função de desagregação. Para tal, foram analisados os dados de precipitação máxima mensal, fornecidos pelo Laboratório de Agroclimatologia da Embrapa Clima Temperado. Foram calculadas as intensidades pelos métodos de Gumbel e Jau, com as durações de 5, 10, 15, 25, 30, 60, 120, 360, 720 e 1440 minutos e o tempo de retorno de 5, 10, 20, 50 e 100 anos. A partir destes valores foram feitos cálculos de Erro Padrão de Estimativa e geradas as curvas IDF, onde os resultados foram comparados nos tempos de retorno mencionados anteriormente.

  10. Relações entre precipitações intensas de diferentes durações ocorridas no município de Urussanga, SC Relationships between heavy precipitations of different durations in the municipality of Urussanga, SC

    Directory of Open Access Journals (Sweden)

    Álvaro J. Back

    2009-04-01

    Full Text Available Neste trabalho se analisaram os pluviogramas do período de 1981 a 2004 da estação meteorológica de Urussanga, SC (Latitude 28° 31' S, longitude 49° 19' W, altitude 49 m. A partir das séries de chuvas máximas anuais foram estimadas, por meio da distribuição de Gumbel-Chow, as chuvas máximas com durações variando de 5 min a 24 h, e também para a duração de 1 dia considerando-se os períodos de retorno de 2, 5, 10, 20, 25, 50 e 100 anos. A aderência dos dados ao modelo de Gumbel-Chow foi comprovada através do teste de Kolmogorov-Smirnov, com nível de significância de 5%. A razão entre a precipitação máxima de 24 h e a precipitação máxima de 1 dia variou de 1,17 para o período de retorno de 2 anos até 1,11 para o período de retorno de 100 anos, com média de 1,13. Ajustaram-se os coeficientes da equação proposta por Bell a fim de estimar a relação entre a chuva com duração t min e período de retorno T anos, em função da chuva máxima com período de retorno de 10 anos e duração de 1 h. Do mesmo modo, se ajustaram também os coeficientes da equação de Bell cuja base foi a chuva máxima com período de retorno de 10 anos e duração de 1 dia.Recorded rainfalls in the period from 1981 to 2004 at the meteorological station of Urussanga, SC (Latitude 28° 31' S, longitude 49° 19' W, altitude 49 m, were analyzed. From the series of annual maximum precipitation, the maximum rainfalls were estimated using the Gumbel-Chow distribution, with durations varying from 5 min to 24 h and also for the duration of one day, considering the return periods of 2, 5, 10, 20, 25, 50 and 100 years. The adherence of the data to the Gumbel-Chow model was proven through the Kolmogorov-Smirnov test with a significance level of 5%. The ratio between the 24 h maximum precipitation and the maximum precipitation of one day varied from 1.17 to 2 years return period up to 1.11 for the 100 years return period, with average of 1.13. The

  11. Erosivity under two durations of maximum rain intensities in Pelotas/RS = Erosividade sob duas durações de intensidades máximas da chuva em Pelotas - RS

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    Jacira Porto dos Santos

    2012-04-01

    Full Text Available In the Universal Equation of Soil Loss (USLE, erosivity is the factor related to rain and express its potential to cause soil erosion, being necessary to know its kinetic energy and the maximum intensities of rain in duration of 30 min. Thus, the aim of this study was to verify and quantify the impact of the rain duration, considering 15 and 30 min, on the USLE erosivity factor. To achieve this, 863 rain gauge records were used, duiring the period of 1983 to 1998 in the city of Pelotas, RS, obtained from the Agrometeorological Station - Covenant EMBRAPA/UFPel, INMET (31o51´S; 52o21´O and altitude of 13,2 m. With the records, it was estimated the erosivity values from the maximum intensities of rain during the period evaluated. The average annual values of erosivity was 2551,3 MJ ha-1 h-1 ano-1 and 1406,1 MJ ha-1 h-1 ano-1, for the average intensities of 6,40 mm h-1 and 3,74 mm h-1, in durations of 15 and 30 min, respectively. The results of this study have shown that the percentage of erosive rainfalls in relation to the total precipitation was of 91.0%, and that the erosivity was influenced by the duration of the maximum intensity of rain.= Na Equação Universal de Perdas de Solo (EUPS a erosividade é o fator relacionado à chuva e expressa o seu potencial em provocar a erosão do solo, sendo necessário que se conheça a energia cinética da mesma e as máximas intensidades da chuva na duração de 30 min. Objetivou-se com este trabalho verificar e quantificar o impacto da duração da chuva, considerando 15 e 30 min, sobre o fator erosividade da EUPS. Para tanto foram utilizados 863 registros pluviográficos de chuva, no período de 1983 a 1998 da localidade de Pelotas, RS, obtidos na Estação Agroclimatológica – Convênio EMBRAPA/UFPel, INMET (31o51´S;52o21´O e altitude de 13,2 m. Com os registros foram estimados os valores de erosividade a partir de intensidades máximas de chuva nas durações consideradas. Os valores m

  12. Comparison of autogenous mucosal grafts and collagen-based, solvent-preserved allografts for vestibuloplasty.

    Science.gov (United States)

    Sezer, Bahar; Selçuk, Ender; Ertürk, Selda; Gomel, Murat

    2004-03-01

    This study was designed to determine whether solvent-preserved dura mater and fascia lata grafts would be as effective as palatal mucosal grafts for vestibuloplasty. All graft systems succeeded in covering the alveolar ridge with firmly attached tissue, which is needed to ensure prosthetic stability. There was no remarkable reduction in area until the stents were removed. However, after 6 months of vestibuloplasty, there was a significant reduction in gained vestibular area in the fascia lata group, whereas no significant difference between dura mater and palatal grafts was observed. These findings suggest that dura mater could serve as a biologic oral dressing for mucosal defects as effectively as palatal grafts in vestibuloplasty.

  13. CGRP infusion in unanesthetized rats increases expression of c-Fos in the nucleus tractus solitarius and caudal ventrolateral medulla, but not in the trigeminal nucleus caudalis

    DEFF Research Database (Denmark)

    Bhatt, Deepak K; Ramachandran, Roshni; Christensen, Sarah Louise Tangsgaard

    2015-01-01

    sites in the brain stem for processing cardiovascular signals. We also investigated Zif268 protein expression (another immediate early gene) in TNC. The protein expression of p-ERK, p-CREB and c-Fos was analyzed in dura mater, trigeminal ganglion (TG) and TNC samples using Western blot. RESULTS: CGRP...... in the TNC was also not changed after CGRP infusion. p-ERK was increased in the dura mater 30 minutes after CGRP infusion. CONCLUSION: CGRP infusion increased the early expression of p-ERK in the dura mater but did not increase c-Fos and Zif268 expression in the TNC. The rats may, thus, differ from migraine...

  14. Estandarización de la técnica molecular de AFLP en palma de aceite tipo Dura (Elaeis guineensis Jacq. y estudio preliminar de caracterización

    Directory of Open Access Journals (Sweden)

    Galeano Carlos Hernando

    2005-06-01

    Full Text Available

    La palma de aceite (Elaeis guinnensis Jacq. desempeña un importante papel en la econo­mía de algunos países tropicales; Colombia ocupa el primer puesto en producción en América Latina y el quinto lugar a nivel mundial. En esta especie el mejo­ramiento genético busca generar materiales con alta producción de aceite y adaptados a las características edafoclimáticas de las diferentes zonas palmeras. El objetivo del presente trabajo fue estandarizar la téc­nica de AFLP (Amplified Fragment-Length Polymorphisms en materiales Dura del Programa de Fitomejora­miento de CENIPALMA. Al protocolo de AFLP de la casa comercial se le realizaron algunas modificacio­nes, como el aumento de la concentración del ADN (270 ng· μL-1 y la dilución 1:10 del producto de la preamplificación. De igual forma, se determinó que para teñir los geles de poliacrilamida con nitrato de plata es necesario usar agua destilada deionizada (Milli Q. También se realizó un estudio prelimi­nar de caracterización molecular en 12 palmas de los tipos Dura, Ténera y E. oleifera; según los agrupa­mientos hechos según métodos fenéticos y multiva­riados se encontró que la mayoría de palmas Dura se agrupan según el lugar de colecta, mientras la palma de origen americano se ubica de forma distante al compararla con las palmas de origen africano.

  15. Início da tuberização, duração do ciclo vegetativo e tolerância ao calor em genótipos de batata

    Directory of Open Access Journals (Sweden)

    Danilo Hottis Lyra

    2015-07-01

    Full Text Available Resumo: O objetivo deste trabalho foi avaliar a relação do tempo para o início da tuberização e da duração do ciclo vegetativo com a tolerância ao calor em batata. Grupos de clones com diferentes tempos para o início de tuberização e durações do ciclo vegetativo foram definidos e avaliados em dois ambientes, e seus índices morfofisiológicos foram estimados em condições de estresse de calor. A amplitude para o início da tuberização foi de 31,8 dias e para a duração do ciclo vegetativo de 30,3 dias. Os grupos de clones formados apresentaram os seguintes parâmetros: tuberização precoce e ciclo vegetativo curto, tuberização precoce e ciclo longo (PL, tuberização tardia e ciclo curto e tuberização tardia e ciclo longo. Em condições de estresse de calor, a produção de tubérculos graúdos do grupo PL apresentou média superior à dos demais grupos. Seis clones (IRF 10-24, IRF 7-61, IRF 2-71, IRF 2-14, IRF 6-104 e IRF 10-44 e três testemunhas ('Markies', CBM 16-16 e CBM 9-10 foram considerados tolerantes ao estresse de calor (média diária de 21,2ºC e responderam favoravelmente ao ambiente com temperaturas amenas (média diária de 19,0ºC. A partição de matéria seca para os tubérculos foi mais rápida nos clones do grupo PL. Os clones de tuberização precoce e ciclo vegetativo longo apresentaram maior tolerância ao calor, com maior produção de tubérculos do que os demais grupos.

  16. The Cause of the Second Labor Cesarean Delivery and Its Influence on Mater and Infant%第二产程剖宫产的原因以及对母婴的影响研究

    Institute of Scientific and Technical Information of China (English)

    沈霞

    2014-01-01

    Objective:To investigate the causes of the second labor cesarean section and its impact on mater and infant,reduce the rate of complications on mater and infant.Method:Two hundred and four cases of parturients give parallel cesarean delivery operation in our hospital from August 2011 to November 2013 were selected as research objects. They were divided into the the first stage and the second stage of labor group. Puerpera clinical data were retrospectively analyzed,surgical indications,complications rate,mater and child condition were compared between the two groups.Result:19 cases of macrosomias and 28 cases of amniotic fluid polluters were seen in the first stage of labor group,while in the second stage of labor group were 31 cases and 44 cases separately.The differences between the two group were significant(P<0.05).The incidence of malpositions in the first stage of labor group was significantly lower than the second stage of labor group(P<0.05).The incidences of complications during(1.8%) and after(1.8%) the operation were also significantly lower than that of the second stage of labor group 19.6%,10.9%for during and after the operation separately(P<0.05).Conclusion:The second line labor cesarean section can damage the mater and newborn in some degree. The incidence of postoperative complications can be increased in this situation. So the parturients should try to avoid the second line labor cesarean section,if not,the experienced doctors are needed for the operation. Avoiding the complications the preoperative sufficient preparation is also needed.%目的:探讨第二产程剖宫产的原因及其对母婴的影响,降低母婴并发症发生率。方法:选取2011年8月-2013年11月于笔者所在医院待产并行剖宫产手术产妇204例为研究对象,将其分为第一产程组与第二产程组两组,对比两组手术指征、并发症发生率、母婴情况等。结果:第一产程组出现巨大儿19例、羊水污染28例,明显

  17. Efeito do treinamento físico de membros superiores aeróbio de curta duração no deficiente físico com hipertensão leve

    OpenAIRE

    Haddad Sandra; Silva Paulo Roberto Santos; Pereira Barretto Antonio Carlos; Ferraretto Ivan

    1997-01-01

    OBJETIVO: Verificar as alterações provocadas pelo treinamento físico (TF), com membros superiores (MMSS), em condição aeróbia de curta duração, sobre variáveis dos sistemas cardiovascular e metabólico. MÉTODOS: Foram estudados 11 deficientes físicos (DF) paraplégicos, com média de idade de 59 anos, sendo 7 homens e 4 mulheres, com lesão de T9 a T11 e grau leve de hipertensão arterial sistêmica (HAS). Os DF foram avaliados antes e após 12 semanas de um programa de TF supervisionado de MMSS, po...

  18. Percepção de sono: duração, qualidade e alerta em profissionais da área de enfermagem How nursing staff perceive the duration and quality of sleep and levels of alertness

    Directory of Open Access Journals (Sweden)

    Frida Marina Fischer

    2002-10-01

    Full Text Available Foi realizado um estudo entre auxiliares de enfermagem e enfermeiros que trabalhavam em hospital público de São Paulo. A organização dos turnos diurnos e noturnos fixos era de 12 horas diárias, seguidas de 36 horas de descanso. O objetivo deste estudo foi avaliar a percepção da duração e qualidade dos episódios de sono nos dias de trabalho e de descanso, bem como dos níveis de alerta durante os turnos diurnos e noturnos de 12 horas de trabalho. Comparadas as durações dos episódios de sono, foram detectadas diferenças significativas entre sono diurno e noturno (Teste t de Student = 10,82; p This study was conducted among health care personnel (registered nurses and nurse aides in a public hospital in São Paulo, Brazil. Work was organized in 12-hour daytime or nighttime shifts, followed by 36 hours off. The study aimed to evaluate how the nursing staff perceived the duration and quality of sleep both during and off work days, as well as their perception of alertness during working hours. There were significant differences between night and day in the duration of sleep (Student t test = 10.82; p < 0.000. Quality of daytime sleep after working night shifts was perceived as worse than nighttime sleep (Wilcoxon test, Z = 2.67; p < 0.007. Significant differences were detected in self-evaluation of alertness after the 2nd, 6th, and 10th hour of night shifts (Friedman = 63.0; p < 0.00. Alertness was perceived as worse during dawn hours. This is an indication of sleepiness at work and can have serious consequences for both health care workers and patients.

  19. Duração do período de formação do grão em trigo Duration of the grain filling period in wheat

    Directory of Open Access Journals (Sweden)

    E.A. Osório

    1995-08-01

    Full Text Available Admitindo a existência de correlação positiva entre o tempo de enchimento dos grãos e a produtividade, foi estudada a duração do período de formação dos grãos em cultivares brasileiras de trigo. Os resultados obtidos demonstram existir grande variação entre cultivares na duração deste período, o qual mostrou-se menor nas cultivares tardias de ciclo vegetativo longo. Destacaram-se, por possuírem longo período de formação dos grãos, as cultivares super-precoces SB 7519, CEP 7596 e IAS 58; as cultivares precoces Jacui, PF 75171, CNT 9, PEL 72393, Frontana, PAT 7392, IAS 54, Coxilha, Cotiporã e Nobre e as cultivares de ciclo intermediário CNT 8 e PEL 72390. Nenhuma cultivar tardia dentre as testadas evidenciou longo período do espigamento à colheita.Assuming positive correlation between the grain filling period duration and yield this character was studied for 38 Brazilian wheat cultivare. Results demonstrate a great variation in the gram filling period duration that was shorter in late than hi earlier cultivars. The following earlier and semi-late cultivare had the longest grain filling period: SB 7519, CEP 7596, IAS 58, Jacui, PF 75171, CNT 9, PEL 72393, Frontana, PAT 7392, IAS 54, Coxilha, Cotiporã, Nobre CNT 8 and PEL 72390. None of the tested late cultivars has shown a long period from heading to harvest.

  20. The present situation and countermeasure analysis on higher vocational graduates towards alma mater satisfaction--Case study of a higher vocational demonstration colleges in Guangdong Province%高职毕业生对母校满意度现状及对策分析--以广东省某高职示范院校为例

    Institute of Scientific and Technical Information of China (English)

    赵晋芳

    2015-01-01

    Based on the analysis of higher vocational graduates towards alma mater satisfaction, it can analyse influence factors and put forward some countermeasures to improve the higher vocational graduates towards alma mater satisfaction. So it can provide reference for improving the quality of higher vocational education and sustainable development in higher vocational colleges.%在分析高职毕业生对母校满意度现状的基础上,分析影响因素并提出提升高职学生对学校的满意度对策,为提高高职院校人才培养质量以及高职院校可持续发展提供借鉴。

  1. Effect of porosity on the thermal expansion coefficient: A discussion on the paper ‘Effects of mineral admixtures on the thermal expansion properties of hardened cement paste' by Z.H. Shui, R. Zhang, W. Chen, D. Xuan, Constr. Build. Mater. 24(9) (2010) 1761–1767

    OpenAIRE

    Ghabezloo, Siavash

    2010-01-01

    A discussion is presented on the effect of porosity change on the thermal expansion coefficient of porous materials. It is shown that both drained and undrained thermal expansion coefficients normally increase with porosity increase. Consequently the reduction of the thermal expansion coefficient with the porosity increase, as obtained in the experimental results of Shui et al. (Constr. Build. Mater. (2010), 24(9), 1761-1767), can not be considered as a general trend for the behaviour of poro...

  2. Factors associated to the duration of exclusive breastfeeding Factores asociados con la duración de la lactancia materna exclusiva Fatores associados com a duração da lactância materna exclusiva

    Directory of Open Access Journals (Sweden)

    Jhon Henry Osorio Castaño

    2012-08-01

    ó medición de prevalencia de lactancia materna hasta los seis meses. El 50% reportó el uso del chupo o biberón como el factor negativo que más afecta la duración de la lactancia materna exclusiva. El 44.4% mencionó como factores positivos en la duración de la lactancia materna exclusiva la escolaridad alta, la multiparidad, la exposición a un programa de lactancia materna y los ingresos familiares bajos. Conclusión. La literatura disponible provee información sobre los factores asociados a la duración de la lactancia materna exclusiva, aunque la heterogeneidad metodológica de los estudios no permitió evaluar la evidencia científica de los resultados narrados.Objetivo. Identificar a evidência científica disponível a respeito dos fatores associados à duração da lactância materna exclusiva. Metodologia. Revisão sistemática sem meta-análise. Realizou-se estratégia de busca eletrônica de artigos primários publicados em Medline, Lilacs, Scielo e Ovid desde 1990 até 2010 em idioma inglês, espanhol e português. Incluíram-se estudos observacionais e de intervenção que procurassem identificar fatores associados à duração da lactância materna exclusiva no mínimo por três meses. Resultados. Identificaram-se 195 estudos, mas só 18 cumpriram com os critérios de inclusão e de qualidade. O 66.6% realizou medição de prevalência de lactância materna até os seis meses. O 50% reportaram o uso da chupeta ou mamadeira como o fator negativo que mais afeta a duração da lactância materna exclusiva. O 44.4% mencionaram como fatores positivos na duração da lactância materna exclusiva: a escolaridade alta, a multiparidade, a exposição a um programa de lactância materna e os rendimentos familiares baixos. Conclusão. A literatura disponível provê informação sobre os fatores associados à duração da lactância materna exclusiva, ainda que a heterogeneidade metodológica dos estudos não permitiu avaliar a evidência científica dos

  3. Frequency and duration of breast-feeding in Cuban children with Type 1 diabetes mellitus (DM Freqüência e duração do aleitamento materno em crianças cubanas com Diabetes Mellitus Tipo 1

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    Fernando Collado-Mesa

    1998-12-01

    Full Text Available It has been suggested that breastfeeding is a protective factor against Type 1 DM due to anti-infection properties or delay in exposure to other agents in the diet. A descriptive study was carried out using data from the Cuban National Registry of Childhood-Onset Diabetes Mellitus (CNRDM. The goal of the study was to determine the frequency and duration of breast-feeding in Cuban children with Type 1 DM. Four hundred and eighty-six children were registered in the CNRDM between January 1, 1988, and December 31, 1993. Breast-feeding data was obtained from two hundred and sixty three (54.1% of the total registered children. Of these children, two hundred and one (76.4% were breastfed. The median duration of breast-feeding was three months (Total range 144 months. No statistically significant association was found between the mean age at DM or the clinical profile at diagnosis and the breast-feeding duration groups (p >0.05, respectively. In conclusion, Cuban children with Type 1 DM have relatively low frequency of breast-feeding. When breast-feeding is studied without stratifying for different types of breast-feeding (e.g. exclusive and non-exclusive, there is no association found with the age at DM diagnosis or the clinical profiles at diagnosis.Há evidências de que o aleitamento materno age como um fator protetor contra o DM Tipo 1 devido a propriedades antiinfecciosas ou porque retarda a exposição a outros agentes na dieta. Foi realizado um estudo descritivo com dados do Registro Nacional Cubanas de Diabetes Mellitus na Infância (CNRDM. O objetivo desse estudo era determinar a freqüência e duração do aleitamento materno em crianças cubanas com DM Tipo 1. Quatrocentas e oitenta e seis crianças foram cadastradas no CNRDM entre 1 de janeiro de 1988 e 31 de dezembro de 1993. Os dados sobre aleitamento materno foram obtidos de duzentas e sessenta e três crianças (54.1% do total registrado. Dessas crianças, duzentas e uma (76.4% foram

  4. Clinical importance of the middle meningeal artery.

    Science.gov (United States)

    Chmielewski, Przemyslaw; Skrzat, Janusz; Walocha, Jerzy

    2013-01-01

    Middle meningeal artery (MMA)is an important branch which supplies among others cranial dura mater. It directly attaches to the cranial bones (is incorporated into periosteal layer of dura mater), favors common injuries in course of head trauma. This review describes available data on the MMA considering its varability, or treats specific diseases or injuries where the course of MMA may have clinical impact.

  5. Intensidade-duração-frequência de chuvas para o Estado de Mato Grosso do Sul Intensity-duration-frequency of rainfall for the State of Mato Grosso do Sul

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    Glenio G. Santos

    2009-12-01

    Full Text Available A ausência de equações de chuvas intensas para o Estado do Mato Grosso do Sul e a necessidade de maior segurança na elaboração de projetos e dimensionamento de obras hidráulicas, foram o alicerce para, com este estudo, se obtivessem e espacializassem as relações de intensidade, duração e frequência de precipitações para o Estado. Utilizou-se, então, da metodologia da desagregação da chuva de 24 h e se utilizaram dados pluviométricos consistidos de 109 estações disponíveis no banco de dados da Agência Nacional de Águas. As equações de chuvas intensas apresentaram bom ajuste, com coeficientes de determinação acima de 0,99 para todas as localidades estudadas. Os parâmetros ajustados apresentaram alta variabilidade resultando em grandes diferenças nos valores de precipitações intensas esperadas para as diferentes localidades. A espacialização permitiu boa visualização das diferenças evidenciando maiores intensidades esperadas na região centro-norte e as menores intensidades nas regiões sudeste e sudoeste do Estado. Os resultados demonstram a importância da obtenção da equação de intensidade-duração-frequência para cada localidade e sua utilização para a realização de estudos e projetos hidráulicos.Rain intensity data are necessary to increase security of hydraulic projects. The objective of this study was to determine the rain storm equations and the spatial distribution of rain intensity for the State of Mato Grosso do Sul, Brazil. The equations were obtained by disaggregation of 24 h rain data from 109 pluviometric stations available in the National Water Agency (ANA data bank. These equations resulted in coefficients of determination above 0,99 for all localities. The adjusted parameters showed high variability, resulting from different rain intensities in different places of the State. The interpolation of data allowed good visualization of the differences, evidencing higher intensities of rains

  6. Collagen-inspired self-assembling materals

    NARCIS (Netherlands)

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and biofunctional

  7. Alma mater ootab tagasi / Triin Tabur

    Index Scriptorium Estoniae

    Tabur, Triin

    2011-01-01

    Tartu Ülikooli arstiteaduskonna ja sotsiaalministeeriumi koostööna käivitunud täiendusõppeprogrammist, mille eesmärgiks on arstiteaduse põhiõppe lõpetanud, ent kliinilisest tööst eemaldunud arstid raviasutustesse tagasi tuua

  8. Alma mater ootab tagasi / Triin Tabur

    Index Scriptorium Estoniae

    Tabur, Triin

    2011-01-01

    Tartu Ülikooli arstiteaduskonna ja sotsiaalministeeriumi koostööna käivitunud täiendusõppeprogrammist, mille eesmärgiks on arstiteaduse põhiõppe lõpetanud, ent kliinilisest tööst eemaldunud arstid raviasutustesse tagasi tuua

  9. Collagen-inspired self-assembling materals

    NARCIS (Netherlands)

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and

  10. Memória e ritmos temporais: o pluralismo coerente da duração no interior das dinâmicas da cultura urbano-contemporânea

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    Ana Luiza Carvalho da Rocha

    2009-06-01

    Full Text Available Nosso objetivo neste artigo é investir no estudo da memória coletiva no mundo urbano como resultado da ação recíproca de indivíduos e de grupos. Destacamos a importância das formas específicas dos arranjos da vida social segundo a complexidade e dinâmica da vida moderna de seus habitantes. Propomos uma etnografia da duração, para tratar do tempo e da memória no âmbito do campo antropológico. Trata-se de aprofundar a compreensão do processo de territorialização/desterritorialização de identidades sociais no mundo contemporâneo. Sugere-se a noção de ritmo como démarche para o conhecimento do movimento da descontinuidade/continuidade como sistema de valores acionados por tais grupos e de suas formas de sociabilidade no contexto citadino.

  11. Reprodutibilidade da curva força-tempo do estilo "Crawl" em protocolo de curta duração Reliability of front-Crawl's force-time curve in a short duration protocol

    Directory of Open Access Journals (Sweden)

    Augusto Carvalho Barbosa

    2012-03-01

    Full Text Available O objetivo deste estudo foi analisar a reprodutibilidade dos parâmetros biomecânicos da curva força-tempo do estilo "Crawl" em um protocolo de 10 s no nado atado. Dezesseis nadadores do sexo masculino (idade: 20,4 ± 4,0 anos; tempo na prova de 100 m livre: 53,68 ± 0,99 s realizaram dois esforços máximos de 10 s no nado atado. Os parâmetros força pico, força média, taxa de desenvolvimento de força, impulso, duração da braçada, tempo para atingir a força pico e força mínima foram representados pela média de oito braçadas consecutivas obtidas em cada tentativa. Utilizou-se o teste t para observar as diferenças entre os esforços para cada parâmetro. O nível de significância estabelecido foi de 5%. A reprodutibilidade relativa foi medida pelo coeficiente de correlação de Pearson e a consistência entre as duas tentativas pelo coeficiente de correlação intraclasse (CCI. A reprodutibilidade absoluta foi verificada pelo coeficiente de variação (CV. Não foi demonstrada diferença estatisticamente significante para nenhum parâmetro biomecânico quando comparados os dois esforços. Os elevados CCI e baixos CV indicaram alta consistência interna dos parâmetros analisados. Conclui-se que os parâmetros biomecânicos analisados a partir do nado atado são reprodutíveis quando empregado protocolo de curta duração o que demonstra a possibilidade de utilização do protocolo com alto grau de confiabilidade, por parte de treinadores e atletas.The aim of the present study was to analyze the reliability of biomechanical parameters of the front-Crawl's force-time curve in a 10-s protocol. Sixteen national competitive male swimmers (20.4 ± 4.0 years; 100-m best time: 53.68 ± 0.99 s performed two 10-s maximal efforts in tethered swimming. Peak force, average force, impulse, rate of force development, stroke duration, time to peak force and minimum force were represented by the mean of eight consecutive strokes obtained in each

  12. Length of internship influences performance on medical residency exam Duração do internato influencia o desempenho no exame de residência médica

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    Itamar de Souza Santos

    2009-01-01

    Full Text Available OBJECTIVES: Medical education encompasses globally diverse context and conditions. The Brazilian scenario seemed a natural environment to study the influence of medical education programs and internship duration on the entrance exam for medical residency. This investigation evaluates some methods used during the entrance exam for medical residency as a means to make a distinction between candidates with longer clerkships. METHODS: Candidates selected for a residency program performed a multiple-choice (MC, an open question (OQ and OSCE-like tests, an interview and a curriculum analysis for participation in scientific meetings, papers published and voluntary activities. Groups were compared for gender, year of graduation, tests and OSCE scores. RESULTS: Participants were distributed into two groups based on clerkship duration: 2 years or less than 2 years. There was no difference for the MCT score among groups or any of the activities from interview and curriculum analysis. The 2 years clerkship group showed significantly higher OQ (p=0.009 and OSCE-like affective (p=0.025 and knowledge (p=0.002 scores. CONCLUSION: The OSCE test identified some aspects related to competence acquisition and assessed basic skills and attitudes essential to the supervised practice of medicine during residency. OSCE discriminated aspects not perceived by the sole use of knowledge tests.OBJETIVOS: A educação médica mostra contextos e condições globalmente diversas. O cenário no Brasil pode ser considerado um ambiente natural para se estudar a influência da diversidade dos programas de educação médica bem como a duração do internato no exame de entrada para residência médica. Esta investigação avalia alguns métodos usados no exame de entrada para residência médica como métodos para diferenciar os candidatos com internatos mais longos. MÉTODOS: Candidatos selecionados para um programa de residência executaram um teste múltiplas-escolhas (MCT

  13. Morfologia e estabilidade de agregados superficiais de um argissolo vermelho-amarelo sob diferentes manejos de longa duração e mata atlântica secundária

    Directory of Open Access Journals (Sweden)

    Clério Hickmann

    2011-12-01

    Full Text Available Experimentos de longa duração submetidos a diferentes manejos de solo fornecem importantes informações quando as alterações nas propriedades físicas, químicas e biológicas são avaliadas e comparadas às das condições originais do solo. Este estudo teve como objetivo avaliar a morfologia externa e a estabilidade de agregados superficiais de um Argissolo Vermelho-Amarelo sob diferentes tipos de manejo em experimento de longa duração e nas condições sob Mata Atlântica secundária. Foram coletadas amostras de solo deformadas e indeformadas na camada de 0-5 cm, em dois tipos de manejo de solo: plantio direto (PD e preparo com arado de disco + grade pesada (AD + GP. Também foi avaliada, como referência do estado de agregação original do solo, uma área de Mata Atlântica secundária (MS adjacente ao experimento. As amostras indeformadas foram impregnadas com resina de poliéster e, na sequência, lâminas delgadas com 30 µm de espessura foram confeccionadas. Posteriormente, as lâminas foram examinadas em microscópio óptico, acoplado à câmera digital, para obtenção de imagens fotográficas mediante seleção aleatória de campos nas lâminas. As imagens geradas foram processadas pelo programa de computador Adobe Photoshop CS3 para análise de parâmetros relacionados à morfologia externa de agregados (perímetro, área, comprimento do maior eixo, comprimento do menor eixo, diâmetro de Feret, alongamento e arredondamento, que visam fornecer informações sobre o tamanho, a forma e a rugosidade dos agregados. Para as amostras deformadas, além da estabilidade dos agregados em água em classes de tamanho 4-2; 2-1; 1-0, 5; 0,5-0,25; 0,25-0,105; e < 0,105 mm de diâmetro, foi determinado o C orgânico total (COT. Foram calculados: diâmetro médio ponderado (DMP, diâmetro médio geométrico (DMG e índice de estabilidade de agregados (IEA. Houve predomínio da classe de agregados de 4-2 mm nos dois tipos de manejo e na MS

  14. Sementes de soja perene. resultados da escarificação e duração do poder germinativo Methods of scarification of seeds of Glycine Javanica L. germination facilities and capacity

    Directory of Open Access Journals (Sweden)

    Neme Abdo Neme

    1963-01-01

    Full Text Available A Seção de Leguminosas do Instituto Agronômico do Estado de São Paulo iniciou, em 1956, a distribuição de sementes de soja perene (Glycine javanica L.. A partir dessa data, vem aumentando a área cultivada com essa planta, no Estado, para formação de pastagens mistas, consorciada com capins, para culturas exclusivas e, ainda, para conservação do solo. Essa leguminosa possui sementes duras, com tegumento impermeável à água, o que impede a germinação normal. Para boa germinação, devem ser escarificadas. O autor indica um método para escarificação de pequenos lotes de sementes e outro para grandes quantidades e estabelece as seguintes conclusões: 1 nas sementes sem escarificação a germinação varia entre 7 e 24%; 2 a escarificação em pilão e em máquina de beneficiar arroz proporciona germinação superior a 70%; 3 não ocorre o fenômeno de dormência nessas sementes, pelo menos do tipo que possa ser eliminado pelo repouso; 4 as sementes escarificadas mantêm a capacidade germinativa, pelo menos até três anos, tempo que abrangeu a duração do experimento.In 1956 the Leguminous Plants Department of the Instituto Agronômico at Campinas started the distribuition oí seeds of Glycine javanica L. to a few farmers of the State of S. Paulo. From then onwards the area under cultivation of this plant has increased considerably. It has been recommended for growing exclusively, for the formation of mixed pastures associated with grass and also for soil conservation purposes against soil erosion. The seeds are hard, their tegument being impermeable to water, which hinders normal germination. For good germination the seeds have to be scarified. The author indicates a method when one has to scarify small quantities of seeds and another for larger quantities and establishes the following conclusions: 1 The germination of seeds without undergoing scarification varied between 7% and 24% 2 Seeds when scarified with pestle and mortar

  15. Comparação de diferentes metodologias para estimativa de curvas intensidade-duração-freqüência para Pelotas - RS Comparison of different methodologies to estimate intensity-duration-frequency curves for Pelotas - RS, Brazil

    Directory of Open Access Journals (Sweden)

    Rita de C. F. Damé

    2008-06-01

    Full Text Available Nos projetos agrícolas de obras hidráulicas, onde não se dispõe de dados observados de vazão, é necessário explorar ao máximo as informações relativas às curvas Intensidade-Duração-Freqüência (IDF. Diante disso, é preciso obter maneira de desenvolver metodologias de estimativas de curvas IDF, em locais que possuam pouco ou nenhum dado pluviográfico. O objetivo do trabalho foi comparar as metodologias de desagregação de precipitações diárias para verificar o ganho de informação em termos de curvas IDF, comparadas àquela obtida a partir de dados observados (histórica. Os métodos utilizados foram: (a Método das Relações (CETESB, 1979; (b BELTRAME et al. (1991; (c ROBAINA & PEITER (1992; (d Modelo Bartlett-Lewis do Pulso Retangular Modificado (DAMÉ, 2001. Utilizou-se de série de dados de precipitação diária de Pelotas - RS, referente ao período de 1982-1998. Para estimar as curvas IDF, a partir dos registros históricos, foram estabelecidas as durações de 15; 30; 60; 360; 720 e 1.440 minutos, e os períodos de retorno de 2; 5 e 10 anos. Os valores de intensidades máximas foram comparados entre si, pelo teste "t" de Student, para os coeficientes linear e angular, e pelo Erro Relativo Médio Quadrático. O método que melhor representou as intensidades máximas de precipitação, nos períodos de retorno de 2 e 10 anos, foi o Método das Relações (CETESB, 1979.Agricultural projects which deal with hydraulic projects and do not possess observed data on outflow need to explore at the most, information about the Intensity-Duration-Frequency (IDF curves. Thus, it is necessary to create ways to develop methodologies that estimate IDF curves for locations that have little or no pluviometric data. The aim of this work was to compare disaggregation methodologies for daily precipitation, to verify the increase in quality information considering the IDF curves, as compared to those originated from observed data

  16. Morfologia e duração do desenvolvimento pós-embrionário de Chrysomya megacephala (Diptera: Calliphoridae em condições de laboratório

    Directory of Open Access Journals (Sweden)

    Karine Brenda Barros-Cordeiro

    2010-01-01

    Full Text Available A morfologia e o tempo de desenvolvimento pós-embrionário de Chrysomya megacephala (Fabricius criada em condições de laboratório e em dieta de carne bovina, foi descrita e comparada ao de outras espécies. Os parâmetros analisados foram à duração dos instares larvais e a morfologia. Para isso as larvas foram fixadas e preservadas em intervalos de tempo de 2 horas, desde a eclosão das larvas até a 50ª hora, a fim de se determinar o tempo de desenvolvimento de cada estágio. O tempo total de desenvolvimento larval para C. megacephala foi de 98 horas, com média de comprimento 15,51 mm. Essa espécie tem comportamento necrobiontófago e de importância sanitária e médico-legal, usada na estimativa do intervalo post-mortem em investigação criminal.Morphology and duration of the post-embryonary development of Chrysomya megacephala (Diptera: Calliphoridae in laboratory conditions. The morphology and developmental time of the post-embryonic stage of Chrysomya megacephala (Fabricius reared in laboratory on a beef diet, is described and compared to those of other blow-flies species. The parameters analyzed were the duration of the larval stages and the morphology. Larvae were fixed and preserved at 2 hours intervals, from larval eclosion until the 50th hour of life, in order to determine the duration of each stage. The total period of larval development in C. megacephala was 98 hours and their mean length was 15.51 mm. This species presents a necrobiontophagous behavior and has sanitary and medico-legal importance, being used for estimating postmortem interval in criminal investigations.

  17. Silagem de grãos úmidos de milho de textura dura ou macia em dietas com polpa cítrica para vacas em lactação

    Directory of Open Access Journals (Sweden)

    F.M.J. Costa

    2014-02-01

    Full Text Available Avaliou-se o desempenho de vacas leiteiras que consumiram polpa cítrica e dois teores dietéticos de silagem de grão úmido de milho. Os tratamentos foram: milho de textura dura ou milho de textura macia ensilado na linha negra, em fatorial com 9% ou 18% de milho na dieta. O teor de polpa cítrica na dieta foi de 16,2% ou 25,6%, com alto e baixo milho, respectivamente. Doze vacas receberam os tratamentos em quadrados latinos 4x4. A produção diária de leite foi 27,9kg no milho duro e 28,8 no macio (P=0,19. Alto milho diminuiu o teor de gordura do leite de 3,38 para 3,26% (P=0,04 e aumentou o teor de proteína de 2,99 para 3,03% (P=0,05 e a eficiência alimentar de 1,50 para 1,57kg de leite/kg de consumo (P=0,03. Aumento no teor de milho induziu maior queda no pH ruminal na dieta com milho macio do que na dieta com milho duro (P=0,05 para a interação textura versus teor de milho. O milho macio aumentou o consumo diário de matéria orgânica digestível de 11,7 para 12,3kg (P=0,05. Os parâmetros digestivos sugerem que a ensilagem não eliminou totalmente o efeito da textura do endosperma sobre a digestibilidade do milho.

  18. Determinação da relação potência-duração em exercício com membros superiores Determination of the power-duration relationship in upper-limb exercises

    Directory of Open Access Journals (Sweden)

    Domingos Belasco Junior

    2010-08-01

    Full Text Available OBJETIVOS: Determinar a relação potência-duração em exercícios de membros superiores (MMSS e verificar a relação dos parâmetros derivados dessa função com indicadores fisiológicos de aptidão aeróbia. Métodos: Dez homens saudáveis (26,2±2,3 anos, 75,0±11,8 kg, 178,2±11,5 cm e 15,0±5,7% de gordura realizaram um teste de rampa em cicloergômetro de braço com incrementos de 20 W/min. Posteriormente, cinco testes de carga constante até a exaustão a 70, 80, 90, 95 e 100% da diferença entre LV1 e o VO2pico foram realizados. A potência crítica (PC foi obtida por meio da linearização da função potência-duração. RESULTADOS: A relação potência-duração foi descrita pela função ajustada (r=0,98±0,02. O VO2 na PC (2,66±0,62 l/min foi maior do que no LV1 (1,62±0,38 l/min e LV2 (2,36±0,59 l/min, respectivamente, mas menor do que o VO2pico (3,06±0,62 l/min. A carga da PC (103,0±26,0 W foi diferente da encontrada em LV1 (69,5±21 W e VO2pico (151,0±26,3 W, mas não da em LV2 (103,5±30,8 W. A associação entre a PC e esses indicadores de aptidão aeróbia foram todas significantes quando expressas em VO2 (0,73 a 0,78; pOBJECTIVES: To determine the power-duration relationship in upper limb exercises and to investigate the relationships between parameters derived from this function with physiological indicators of aerobic fitness. METHODS: Ten healthy men (26.2±2.3 years, 75.0±11.8 kg, 178.2±11.5 cm and 15.0±5.7% body fat performed a ramped test on an arm cycle ergometer with increments of 20 W/min. Subsequently, five tests with constant load were performed until exhaustion, with 70, 80, 90, 95 and 100% difference between VT1 and VO2peak. The critical power (CP was obtained by means of linearization of the power-duration function. RESULTS: The power-duration relationship was described using an adjusted function (r=0.98±0.02. The VO2 at CP (2.66±0.62 l/min was higher than VT1 (1.62±0.38 l/min and VT2 (2.36±0

  19. Discrimination between spinal extradural meningioma and both intra and extradural meningioma: Case Report.

    Science.gov (United States)

    Ito, Kenyu; Imagama, Shiro; Ando, Kei; Kobayashi, Kazuyoshi; Hida, Tetsuro; Tsushima, Mikito; Matsumoto, Akiyuki; Morozumi, Masayoshi; Tanaka, Satoshi; Nishida, Yoshihiro; Ishiguro, Naoki

    2017-02-01

    Meningiomas are common spinal tumor and mostly located at intradura. Recurrence rate after surgery for extradural meningioma was higher than intradural meningioma. A patient with intra and extradural spinal meningioma was treated and discussed its features and clinical management. A 41-year-old woman noted numbness of bilateral legs, gait disturbance, and mild bladder disturbance for over the two-month period. Magnetic resonance imaging revealed an epidural mass at T8-9 involving the dura mater from the left side. Intraoperatively, ultrasonography showed extradural tumor suppress the dura from the left side and no subarachnoid space. Therefore, it was difficult to diagnose the tumor was located at only extradural or both intra and extradural. The extradural tumor was resected as much as possible, then ultrasonography was performed for the second time. The spinal cord was decompressed and subarachnoid space was appeared with intradural tumor. The dura mater was opened in the midline for intradural exploration, and the intradural tumor appeared beside the spinal cord. The dura mater with attachment to the tumor was rescected. To prevent a recurrence, ultrasonography after removing extradural tumor is recommended to detect intra dural tumor and invasion of tumor into dura mater. In such case, removing only extradural meningioma is not enough, and gross total resection including intradural meningioma and dura mater is required.

  20. História recente e perspectivas atuais da pesquisa de resultados em psicoterapia psicanalítica de longa duração Recent history and current perspectives of outcome studies on long-term psychoanalytic psychotherapy

    Directory of Open Access Journals (Sweden)

    Simone Isabel Jung

    2006-12-01

    Full Text Available Este artigo apresenta a história recente - dos anos 90 a janeiro de 2006 - e as perspectivas atuais da pesquisa de resultados em psicoterapia psicanalítica de longa duração com pacientes adultos em ambulatório. São analisadas e citadas 21 investigações, das quais quatro foram desenvolvidas na América Latina e apenas uma no Brasil. Isso demonstra que, apesar da evolução nas investigações psicanalíticas de resultado, nos países latinos, o número de pesquisas ainda é escasso. A efetividade da psicoterapia psicanalítica é demonstrada de maneira significativa, com diversos delineamentos de pesquisa. Percebe-se uma evolução na metodologia de pesquisa utilizada nas investigações no decorrer dos anos. A preocupação em colocar a investigação psicanalítica consoante com princípios científicos, sem desconsiderar a subjetividade característica dessa abordagem, é marcante. Ressalta-se a importância da investigação psicanalítica para confirmar os pressupostos do corpo teórico e a eficácia/efetividade do tratamento e possibilitar a refutação e modificação da teoria psicanalítica.This article shows the recent history (from the 1990's to January 2006 and current perspectives of outcome studies on long-term psychoanalytic psychotherapy in adult outpatients. Twenty-one inquiries are cited and analyzed, of which four were developed in Latin America and only one in Brazil. This shows that research is still scarce in Latin-American countries, despite the advances on outcome psychoanalytical investigations. The effectiveness of psychoanalytic psychotherapy was evidenced in a significant manner by several different research outlines. An evolution in research methodology used over the past years could be observed. The concern about placing the psychoanalytical investigation in association with scientific principles, without disregarding the subjectivity characteristic of this approach, is remarkable. The importance of

  1. Seguridad pública y neoconservadurismo en la Argentina neoliberal: La construcción social de la "inseguridad" durante los años noventa: "combate a la delincuencia", "tolerancia cero" y "mano dura"

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    Pedro Cerruti

    2013-12-01

    Full Text Available En el presente trabajo se indaga el modo en que se construyó a la "inseguridad" en un problema público-político durante la segunda mitad de la década de los noventa como una modalidad de representación en términos delictivos y de gestión policíaca de la conflictividad y la inseguridad social. Se parte de la hipótesis de que dicha construcción formó parte de un proceso de transformación de la sociedad argentina asociado con la reforma neoliberal del Estado. Para demostrarlo, brevemente se sitúan, como antecedentes inmediatos al período de análisis, algunas de las principales consecuencias sociales de la reforma neoliberal iniciada durante la última dictadura cívico-militar (1976-1983 y se destaca al período hiperinflacionario (1989-1990 como el momento en el que emergen los discursos sobre la "inseguridad". Luego, se analiza en detalle el modo en que durante la década de los noventa la "inseguridad" se conformó como una de las principales preocupaciones de la opinión pública, uno de los temas decisivos en las disputas políticas y se introdujo como eje prioritario en la agenda de gobierno del presidente Carlos Menem a través de una campaña mediático-política de "combate a la delincuencia" ordenada en los términos de la "mano dura" y la "tolerancia cero". A través de dicha indagación, se argumenta que la "inseguridad" constituyó el vórtice de una matriz discursiva que legitimó un paradigma neoconservador de gestión de las consecuencias sociales de la reestructuración económica neoliberal y operó como un mecanismo reproductor de la exclusión social.

  2. Consistência hidrológica de modelos digitais de elevação (MDE para definição da rede de drenagem na sub-bacia do horto florestal Terra Dura, Eldorado do Sul, RS

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    Anna Hoffmann Oliveira

    2012-08-01

    Full Text Available O desenvolvimento da erosão hídrica ocorre em resposta ao modo como a água se move através e sobre uma determinada paisagem. O modelo digital de elevação (MDE deve, portanto, ser o mais preciso possível, uma vez que constitui a base para a análise do relevo. Este trabalho teve como objetivo definir um modelo digital de elevação hidrologicamente consistente (MDEHC e o método de direção de fluxo mais adequado para a definição da rede de drenagem na sub-bacia do horto florestal Terra Dura, município de Eldorado do Sul, RS. Foram testados os modelos gerados com os interpoladores Topogrid e redes triangulares irregulares (Triangulated Irregular Network -TIN linear (TIN L e TIN natural neighbor (TIN NN. A qualidade em relação às análises hidrológicas foi avaliada por meio da comparação das curvas de nível geradas pelos modelos testados com as curvas originais da sub-bacia (escala 1:10.000; da avaliação da quantidade de áreas planas; e da comparação da drenagem gerada pelos modelos a partir dos métodos de direção de fluxo Deterministic (D8 e Deterministic infinity (D∞ ou D infinito com a drenagem original. Entre os modelos avaliados, o Topogrid apresentou maior consistência hidrológica, verificada na melhor continuidade das curvas de nível (menos arestas e maior detalhamento da área de drenagem e divisores, acarretando menor quantidade de áreas planas e caminhos de fluxo mais detalhados, independentemente do método de direção de fluxo utilizado. Em relação à rede de drenagem, o método distribuído D∞ obteve melhor desempenho na descrição dos caminhos de fluxo, comparado ao método de direção única D8. O MDEHC Topogrid associado ao método D∞ proporcionou a identificação mais precisa dos caminhos preferenciais do fluxo que formam a rede de drenagem.

  3. Satisfação conjugal em casamentos de longa duração: uma construção possível Marital satisfaction in long lasting marriages: a feasible construction

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    Maria de Betânia Paes Norgren

    2004-12-01

    Full Text Available O relacionamento conjugal está associado à saúde e qualidade de vida, principalmente nos anos de maturidade e velhice, embora o fato de um casamento durar não necessariamente signifique que o mesmo é satisfatório para os cônjuges. O objetivo do presente estudo foi identificar os processos e variáveis associadas à satisfação conjugal em casamentos de longa duração, ou seja, mais de 20 anos. Trinta e oito casais paulistas responderam a um conjunto de questionários já utilizados em estudo multicultural prévio (Estados Unidos, Suécia, Alemanha, Holanda, Canadá, África do Sul, Israel e Chile. Em cerca de metade dos casais estudados, ao menos um dos cônjuges estava satisfeito. Comparando-se casais satisfeitos e insatisfeitos foi possível identificar que a satisfação aumenta quando há proximidade, estratégias adequadas de resolução de problemas, coesão, boa habilidade de comunicação, se os cônjuges estiverem satisfeitos com seu status econômico e forem praticantes de sua crença religiosa.Marital relationship is related with couple's health and quality of life, especially during the adulthood and the aging years. However, the fact that a marriage is long lasting, does not mean it is necessarily satisfactory to the partners. This paper aims to identify the processes and variables associated to satisfaction in long lasting marriages (those longer than 20 years. Thirty eight couples from São Paulo, Brazil, answered a set of questionnaires used previously in multicultural studies carried out in Sweden, USA, Germany, Canada, Netherlands, South Africa, Israel and Chile. In about half of these couples, at least one consort was found satisfied. Comparing satisfied and unsatisfied couples, it became clear that higher levels of satisfaction are found among couples who have adequate strategies for problem solving, proximity, cohesion, good communication skills; who are religiously active and satisfied with their economical status.

  4. Risk of field cultivation of pickling cucumber caused by unfavorable sunshine duration conditions Risco do cultivo de campo de pepino decapado causado por condições desfavoráveis de duração de brilho solar

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    Robert Kalbarczyk

    2011-06-01

    L. decapado causado pelo curso desfavorável de duração da radiação solar na Polônia, baseado em um período de 40 anos de pesquisa (1966-2005. A pesquisa foi realizada pelo fato da ocorrência frequente de deficiência de insolação na Polônia e sua alta variabilidade temporal e espacial. O efeito das condições solares descritas pela duração da insolação foi estudado em relação às produtividades total e comerciável de pepino, considerando uma tendência linear de uma variável independente. A precisão das equações foi avaliada com base no coeficiente de determinação, erro médio relativo de precisão e índices: erro médio de bias, erro médio absoluto de bias e raiz do erro médio quadrado. A produtividade foi analisada a partir da emergência até o início do florescimento e do inicio ao fim da colheita. A produtividade de pepino foi 18% menor em relação a media multianual dos anos 1966-2005 cada 1,5-2 anos - nos casos de falta de insolação no período emergência-florescimento e 12-15% menor a cada 2-3 anos na colheita. Com exceção de quarto dentro dos 40 anos estudados, houve condições desfavoráveis de insolação em ambos os estádios estudados, causando uma redução de no mínimo de 5% da produção total da planta na Polônia e, excetos três anos - da produção comercial.

  5. Incidência e duração da amamentação conforme o tipo de parto: estudo longitudinal no Sul do Brasil Incidence and duration of breast-feeding by pattern of delivery: a longitudinal study in Southeastern Brazil

    OpenAIRE

    1998-01-01

    OBJETIVO: Comparar a incidência de amamentação conforme o tipo de parto. MATERIAL E MÉTODO: Estudo de coorte prospectivo de base populacional com 655 crianças brasileiras nascidas no ano de 1993 e acompanhadas durante o primeiro trimestre de vida, através de duas visitas domiciliares. RESULTADOS: A duração da amamentação foi similar entre os nascidos por parto vaginal e cesariana emergencial. Os nascidos por cesariana eletiva apresentaram um risco três vezes maior de interromper a lactação no...

  6. Efeito da duração da amamentação exclusiva e mista sobre os níveis de hemoglobina nos primeiros seis meses de vida: um estudo de seguimento Effect of length of exclusive breastfeeding and mixed feeding on hemoglobin levels in the first six months of life: a follow-up study

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    Andréa Silva de Oliveira

    2010-02-01

    Full Text Available O objetivo deste estudo foi avaliar o efeito da duração da amamentação exclusiva e mista sobre os níveis de hemoglobina de lactentes. Trata-se de um estudo de seguimento com seis meses de duração, envolvendo 150 crianças nascidas na maternidade de Mutuípe, Bahia, Brasil. Mensalmente, as crianças eram submetidas ao exame de sangue para avaliação dos níveis de hemoglobina e realizava-se coleta de dados de consumo alimentar. Foram obtidos, ainda, dados obstétricos e sócio-econômicos. Utilizou-se o modelo linear de efeitos mistos para investigar as associações de interesse. Ao final do seguimento, a perda amostral foi de 15,3%, e detectou-se uma prevalência de 71,7% de anemia. Constatou-se um incremento de 0,091g/dL nos níveis de hemoglobina a cada mês de duração de aleitamento materno exclusivo (p = 0,031, enquanto, a cada mês de duração de aleitamento materno misto, os níveis de hemoglobina declinaram em 0,097g/dL (p = 0,017. Concluiu-se que as práticas alimentares inadequadas parecem estar diretamente envolvidas na etiologia da deficiência nutricional de ferro nesse período da vida.This six-month follow-up study aimed to assessing the effect of length of both exclusive breastfeeding and mixed feeding on hemoglobin levels in 150 infants born at the Mutuípe maternity facility in Bahia State, Brazil. Blood tests were performed monthly to assess the hemoglobin levels, at which time data were gathered on food intake. Obstetric and socioeconomic data were also collected. The linear mixed effects model was used to investigate the target associations. Loss to follow-up was 15.3%, and anemia prevalence was 71.7%. An increase of 0.091g/dL (p = 0.031 in hemoglobin levels was found for each month of exclusive breastfeeding, while a decrease of 0.097g/dL (p = 0.017 was shown for each month of mixed feeding. In conclusion, inadequate food practices appear to be directly involved in the etiology of iron deficiency anemia during

  7. Sleep duration and health status self-assessment (SF-36 in the elderly: a population-based study (ISA-Camp 2008 Duração do sono e estado de saúde autorreferido (SF-36 em idosos: estudo de base populacional (ISA-Camp 2008

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    Margareth Guimarães Lima

    2012-09-01

    Full Text Available The aim of this study was to determine the association between sleep duration and health status among the elderly. A population-based study was carried out with 1,418 elderly individuals using data from the health survey of Campinas, São Paulo State, Brazil (ISA-Camp 2008. Linear regression models were used to determine associations between the physical and mental components and subscales of the SF-36 and sleep duration. Elderly male individuals who slept > 6 hours obtained lower mean SF-36 scores for the vitality and mental health scales and the mental component summary than those who slept for seven to eight hours. All scales were negatively associated with sleep duration Avaliar a associação da duração do sono com o estado de saúde autorreferido em idosos. Estudo de base populacional que utilizou dados do Inquérito de Saúde de Campinas, São Paulo, Brasil (ISA-Camp 2008, com 1.418 idosos. Modelos de regressão linear foram usados para verificar a associação entre as escalas do SF-36 versão 2 e os dois componentes de medida, com a duração do sono. Homens idosos que dormem 6 horas ou menos apresentam as menores médias dos escores do SF-36, comparando com os que dormem 7 a 8 horas, nos domínios de vitalidade e saúde mental. Todas as escalas apresentaram associação negativa com a duração do sono de 10 horas ou mais, exceto em dor. Nas mulheres, o tempo de sono > 5 horas se associou à pior situação nas escalas de saúde mental, aspectos emocionais e vitalidade. Saúde mental se associou negativamente com a duração do sono de 10 horas ou mais nessa população. A privação do sono e o excesso se associaram ao pior estado de saúde nos idosos, de maneira diferente entre os sexos, principalmente considerando o sono longo.

  8. Resistência à penetração, eficiência de escarificadores mecânicos e produtividade da soja em Latossolo argiloso manejado sob plantio direto de longa duração

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    Vitor Caduro Girardello

    2014-08-01

    /moderada, à ocorrência de frequente precipitação pluvial e às favoráveis condições físico-hídricas proporcionadas pelo SPD de longa duração.

  9. Pastoreio de curta duração com ovinos em caatinga raleada no sertão cearense Short duration grazing with sheep on a thinned caatinga in the sertão of Ceará

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    Nilzemary Lima da Silva

    1999-01-01

    Full Text Available A pesquisa foi conduzida em Sobral, Ceará, no período de janeiro de 1992 a julho de 1994 e objetivou determinar o desempenho produtivo de ovinos, produção de forragem e características fitossociológicas do estrato herbáceo da caatinga raleada submetida à adubação orgânica e pastoreio de curta duração, com duas taxas de lotação. Foram testadas as cargas de 3,3 (leve e 10 cab/ha (pesada, com (5 t/ha de esterco de caprinos e sem adubação orgânica. Utilizou-se um delineamento inteiramente casualizado distribuído em um fatorial 2x 2 x 3 (carga animal x adubação x ano, com duas repetições. O pastejo de ovinos resultou no desaparecimento total das gramíneas e no aumento das dicotiledôneas herbáceas no período estudado. A adubação orgânica não mostrou efeitos significantes (P>0,05 quanto à performance animal e das pastagens. O melhor desempenho animal (PThe experiment was carried out in Sobral, Ceará, Brazil, from January 1992 to July 1994, with the objective of determining the productive performance of lambs, forage production, and frequency of the species of the herbaceous layer of a thinned caatinga, under organic fertilization and short duration grazing, with two stocking rates. The stocking rates were 3.3 (light and 10.0 heads/ha (heavy, with (5.0 ton/ha of goat manure and without fertilization. A complete randomized design was followed, with a factorial distribution of 2 x 2 x 3 (stocking rate x fertilization x year, with two repetitions. Sheep grazing resulted in total disapearing of the grass species and an increasing of the forbs, along the period of study. The organic fertilization did not show significant effects (P>0.05 on the animal and pasture performances. The best animal performance (P<0.01 was observed on the padocks under light stocking rate (3.3 head/ha, with 108.0 g/head/day, and the best performance (P<0.01 of the pasture was obtained on the areas under heavy stocking rate (10 head/ha, with 71.2 kg

  10. Investimento e satisfação em curso de curta duração: modelo de avaliação Investment and satisfaction in short-duration course: model of evaluation

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    Newton Kara-Jose

    2008-02-01

    Full Text Available OBJETIVO: Apresentar um modelo de avaliação da satisfação dos participantes de um curso de curta duração, considerando-se o custo financeiro e o conhecimento adquirido. MÉTODOS: Através da aplicação de questionários, foi realizado um estudo transversal em amostra prontamente acessível, formada por oftalmologistas (n=29 que presenciaram o "II Curso de Transferência de Habilidades em Adaptação de Lentes de Contato", no Hospital Sírio-Libanês (SP. RESULTADOS: A amostra foi composta por 29 indivíduos, 58,6% do sexo feminino e 37,9% do sexo masculino (uma pessoa não respondeu à questão. Dos participantes, 41,4% gastaram menos de 800 reais (U$400, 24,1% investiram de 800 a 1000 reais e 34,5%, de 1200 a 3000 reais. A aquisição de conhecimento foi considerada muito satisfatória em 10 (76,92% dos itens questionados; em 3 (23,08%, foi avaliada como mediana e, em nenhum caso, foi considerada pequena ou nula. O curso seria recomendado a outros colegas por 95% dos participantes. CONCLUSÕES: O modelo apresentado permitiu avaliar a expectativa e o ganho de conhecimento em cada item do programa, a eficiência dos módulos de ensino do curso, os custos para os alunos e a satisfação dos participantes.OBJECTIVE: To present a model of assessment of the satisfaction level of the attendants in a short-duration course, considering the financial costs and the acquired knowledge. METHODS: By means of the presentation of questionnaires, a transversal study on a promptly accessible sample of ophthalmologists (n=29 who attended the "II Course on Transfer of Skills on Adaptation to Contact Lenses" at Sirio-Libanês Hospital, was carried out. RESULTS: The sample was formed by 29 individuals, being 58,6% men and 37,9% women (one person did not answered to the question. 41.4% of the attendants have spent less than 800 reais (US$ 400,00; 24.1% have invested from 800 up to 1000 reais; and 34,5%, from 1200 up to 3000 reais. The acquisition of knowledge

  11. A Federalização dos crimes de graves violações dos direitos Humanos: a razoável duração do processo como Garantia no combate à impunidade ou instrumento retórico?

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    Daniel Henrique de Sousa Lyra

    2009-12-01

    Full Text Available Este artigo tem como objeto de estudo o princípio da razoável duração do processo aplicado à criação de um incidente de deslocamento de competência, quando da constatação de ocorrência de crime que viole gravemente os direitos humanos, mais especificadamente, com a sua federalização, com o fito de adequar a legislação aos anseios das transformações sociais. A exposição histórica acerca da gênese dos direitos humanos, o surgimento da Emenda Constitucional n. 45, do ano de 2004, o lacunoso conceito de grave violação aos direitos humanos, completando ainda com a explanação acerca do paralelo que deve haver entre a federalização dos crimes que violam os direitos humanos e o principio constitucional da razoável duração dos processos, ambos inovações constitucionais recentes, são matérias indispensáveis de discussão para que se chegue à conclusões propostas.

  12. Influência da otite média no transtorno fonológico: análise acústica da duração das fricativas do português brasileiro Otitis media influence on phonological disorders: an acoustic analysis for duration of brazilian portuguese fricatives

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    Haydée Fiszbein Wertzner

    2009-03-01

    Full Text Available OBJETIVO: verificar a duração da produção de fricativas surdas e sonoras ensurdecidas em crianças com e sem histórico de otite média (OM. MÉTODOS: 12 crianças (seis com e seis sem transtorno fonológico sendo três com o processo de ensurdecimento de fricativas e OM, três com ensurdecimento sem OM, três sem ensurdecimento com OM e três sem ensurdecimento sem OM, provenientes do LIF em Fonologia do Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional da Faculdade de Medicina da USP-SP. Foram apresentadas as figuras correspondentes às palavras ['fila]x['vila], ['cinco]x['zinco], ['xis]x['giz] para nomeação. Os dados foram coletados e armazenados diretamente no Computerized Speech Laboratory (4300B. RESULTADOS: o grupo sem TF e sem OM produziu os sons sonoros com duração menor que os surdos (diferença estatisticamente significante, assim como o grupo com OM, porém sem significância estatística. Os dois grupos com ensurdecimento, com e sem OM, não apresentaram diferença de duração na produção dos sons. CONCLUSÃO: a OM influencia a percepção de diferenças na duração entre os sons fricativos surdos e sonoros, apesar da duração não ser a única pista acústica para o contraste da sonoridade.PURPOSE: acoustically analyze the duration of voiced and voiceless fricatives produced by children with and without otitis media (OM history. METHODS: 12 children (three having the phonological process of devoicing fricatives with OM, three having devoicing without OM, three without devoicing with OM and three without devoicing and without OM. Children were enrolled in a speech program at the Laboratory of Speech and Language Investigation in Phonology of the University of Sao Paulo, Brazil. They were asked to say the name of the pictures representing the words ['fila]x['vila], ['cinco]x['zinco], ['xis]x['giz]. Data were collected and stored in the Computerized Speech Laboratory (4300B. RESULTS: the duration of

  13. Influência da mobilidade materna na duração da fase ativa do trabalho de parto Influence of maternal mobility on duration of the active phase of labor

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    Eliane Bio

    2006-11-01

    Full Text Available OBJETIVOS: investigar a influência da mobilidade da parturiente durante a fase ativa do trabalho de parto. MÉTODOS: foi realizado ensaio clínico controlado prospectivo, com análise comparativa entre um grupo de tratamento (n=50 e um grupo controle (n=50, no Centro Obstétrico do Hospital Universitário da Universidade de São Paulo (USP. Os critérios de inclusão foram: primigestas com feto único em apresentação cefálica; idade gestacional entre 37 e 42 semanas; parturientes com pelo menos duas contrações a cada dez minutos e cérvico-dilatação de até 4 cm, além da concordância em assinar o termo de consentimento livre e esclarecido. A evolução para cesárea foi critério de exclusão. Foram acompanhadas por fisioterapeuta durante toda a fase ativa e orientadas a manterem-se em posição vertical e em movimento, de acordo com a fase da dilatação cervical e a descida fetal no canal de parto. O grupo controle teve acompanhamento obstétrico sem a presença do fisioterapeuta. Este grupo foi selecionado retrospectivamente, a partir dos registros de prontuário, seguindo os mesmos critérios de inclusão e exclusão. RESULTADOS: foram acompanhadas 58 primigestas entre 15 e 37 anos. Dessas, 50 mulheres (86,2% evoluíram para parto vaginal, sendo que oito (13,7% evoluíram para cesárea e foram excluídas do estudo. Entre as 50 parturientes acompanhadas, a média de duração da fase ativa foi de cinco horas e 16 minutos, enquanto no grupo controle foi de oito horas e 28 minutos (pPURPOSE: to investigate the influence of the maternal mobility during the active phase of labor. METHODS: a prospective clinical trial was conducted through comparative analysis among a treatment group (n=50 and a control group (n=50, in the Obstetric Center of the Hospital Universitário da Universidade de São Paulo (USP. The inclusion criteria were: primigravidae with a single fetus on cephalic presentation, with 37 to 42 weeks of pregnancy, with two

  14. Automedicação em nutrizes e sua influência sobre a duração do aleitamento materno Self-medication in nursing mothers and its influence on the duration of breastfeeding

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    Roberto G. Chaves

    2009-04-01

    Full Text Available OBJETIVO: Investigar a prática da automedicação em nutrizes, principais fármacos utilizados e influência sobre a duração do aleitamento materno. MÉTODOS: Estudo longitudinal tipo coorte realizado com 246 mulheres assistidas na maternidade do Hospital Manoel Gonçalves, em Itaúna (MG. O acompanhamento às mães e recém-nascidos foi realizado mensalmente nos primeiros 12 meses após o parto ou até a interrupção da amamentação. O efeito da prática da automedicação sobre o tempo de aleitamento materno foi analisado por análise multivariada, a partir do modelo de regressão de Cox, com covariáveis dependentes do tempo. RESULTADOS: A automedicação foi praticada por 52,4% das nutrizes. As classes farmacológicas mais utilizadas foram os analgésicos/antipiréticos (54,4%, anti-inflamatórios não-esteroides (15%, espasmolíticos (6,2%, laxantes (3,5%, benzodiazepínicos (3%, descongestionantes nasais (1,4% e antibióticos (0,9%. Os fármacos mais utilizados foram dipirona (31,5% e paracetamol (17,9%. A prática de automedicação associou-se à maior probabilidade de uso de medicamentos com risco de efeitos adversos sobre o lactente ou sobre a lactação (p = 0,000. Contudo, a prática da automedicação não foi associada ao desmame (p = 0,135. CONCLUSÕES: A elevada frequência de automedicação entre as nutrizes e o uso de medicamentos com risco de efeitos indesejáveis sobre o lactente e na produção láctea revelam a necessidade de melhor orientação sobre os riscos da automedicação pelas nutrizes. Contudo, a prática da automedicação não se revelou um fator de risco para o desmame.OBJECTIVE: To investigate the practice of self-medication by nursing mothers, the main drugs used and the influence on the duration of breastfeeding. METHODS: A longitudinal cohort study involving 246 women seen at the maternity unit of Hospital Manoel Gonçalves in Itaúna, state of Minas Gerais, Brazil. A monthly follow-up of mothers and

  15. Relações entre precipitações intensas de diferentes durações para desagregação da chuva diária em Santa Catarina Relationships between intense rainfall of different durations for disaggregation of daily rainfall in Santa Catarina

    Directory of Open Access Journals (Sweden)

    Álvaro J. Back

    2012-04-01

    Full Text Available Com este trabalho objetivou-se determinar as relações entre precipitações de diferentes durações para o Estado de Santa Catarina. Foram estabelecidas as séries de máximas anuais de chuva com duração de 5 a 1440 min de treze estações pluviográficas de Santa Catarina. Para cada duração foram estimadas as precipitações máximas com período de retorno de 2 a 100 anos, com base na distribuição de Gumbel-Chow. A relação média entre a chuva de 24 h e a chuva de um dia independe do período de retorno, com média para o estado de 1,17. Ao se analisar o horário da leitura da precipitação diária verificou-se que esta relação varia de 1,12 a 1,20. Em referência à chuva de 1 h em relação à chuva de 24 h observam-se valores significativamente inferiores aos normalmente usados.The aim of this study was to determine the relationships between rainfalls of different durations for the State of Santa Catarina. The series of annual maximum rainfall were defined with a duration of 5 to 1440 min of thirteen precipitation stations in Santa Catarina. For each duration maximum rainfall were estimated with a return period of 2 to 100 years, based on the Gumbel-Chow distribution. The relationship between the average rainfall of 24 h and one day rain does not depend on the return period, with an average of 1.17 for the State. When analyzing the time reading the daily precipitation it was messed that this ratio varies from 1.12 to 1.20. In relation to 1 h of rain over 24 h of rain it was observed values significantly lower than those normally used.

  16. Modeling precipitation of short duration by means of the modified Bartlett-Lewis rectangular pulse model Modelagem da precipitação de curta duração por meio do modelo de pulsos retangulares de Bartlett-Lewis modificado

    Directory of Open Access Journals (Sweden)

    Álvaro José Back

    2011-09-01

    Full Text Available The objective of this work was to evaluate the mathematical modeling of rainfall of duration less than one hour using the modified Bartlett-Lewis model with six parameters. The data used were for the period October 1980 to December 2007, from recording rain gauges (pluviographs at the meteorological station of Epagri, Urussanga, south of Santa Catarina (latitude 28.31° S, longitude 48.19 ° W. Based on simulations of series with 100 years of data it can be concluded that: the adjustment of the parameters of the modified Bartlett-Lewis model enables the simulation of rain at intervals as small as 5 minutes of duration, preserving the statistical properties of precipitation over various intervals of aggregation in time. In general there was a tendency toward overestimation of the probability of dry periods and underestimation of the covariance for intervals of 24 hours, especially in summer. The total annual rainfall simulated for all time intervals examined remains within the confidence interval of 95%.Este trabalho teve como objetivo avaliar a modelagem matemática da precipitação pluviométrica de duração inferior a uma hora por meio do modelo de Bartlett-Lewis modificado com seis parâmetros. Foi utilizada a série de dados pluviográficos do período de outubro de 1980 a dezembro de 2007 da estação meteorológica da Epagri, Urussanga, Sul de Santa Catarina (latitude 28,31º S, longitude 48,19º W. Com base nas simulações de séries com 100 anos de dados pode-se concluir que: o ajuste dos parâmetros do modelo de Bartlett-Lewis modificado possibilita a simulação de chuvas com intervalos de duração de até 5 minutos preservando as propriedades estatísticas da precipitação em vários níveis de agregação temporal. De forma geral observou-se a tendência de superestimativa da probabilidade dos períodos serem secos e subestimativa da covariância para intervalos de 24 horas, principalmente no verão e que os totais anuais de

  17. Efeito da teofilina associada ao beta2-agonista inalatório de curta ou longa duração, em pacientes com doença pulmonar obstrutiva crônica estável: revisão sistemática

    OpenAIRE

    Zacarias, Eliane Cristina [UNIFESP; Castro,Aldemar de Araújo; Cendon,Sônia

    2007-01-01

    OBJETIVOS: Avaliar se o tratamento com teofilina associada ao beta2-agonista inalatório de curta ou longa duração é mais eficaz que o placebo e que o uso isolado de cada um dos fármacos, para os pacientes com doença pulmonar obstrutiva crônica estável. MÉTODOS: Realizou-se uma revisão sistemática com metanálise, sendo selecionados todos os ensaios clínicos aleatórios e duplo-cegos encontrados na literatura. RESULTADOS: Foram incluídos oito estudos. Teofilina associada ao beta2-agonista vs. pl...

  18. O efeito do banho de imersão na duração do trabalho de parto El efecto del baño de inmersión en la duración del trabajo de parto The effect of immersion baths on the length of childbirth labor

    Directory of Open Access Journals (Sweden)

    Flora Maria Barbosa da Silva

    2006-03-01

    Full Text Available Estudo experimental, randomizado do tipo ensaio-clínico, teve como objetivo identificar a influência do banho de imersão na duração do primeiro período clínico do parto e na freqüência e duração das contrações uterinas. Os dados foram coletados em uma maternidade pública filantrópica da cidade de São Paulo que atende, em média, 1.100 partos mensais. A amostra constou de 108 parturientes, 54 no grupo controle e 54 no experimental, que fizeram uso do banho de imersão. Os resultados demonstraram que o banho de imersão não modificou a duração do trabalho de parto e a freqüência das contrações uterinas. No entanto, a duração das contrações foi estatisticamente menor no grupo experimental (41,9 versus 44,6min. Concluiu-se que o banho de imersão é uma alternativa para o conforto da mulher, durante o trabalho de parto, por oferecer alívio à parturiente, sem interferir na progressão do parto sem trazer prejuízos ao recém-nascido.Este estudio experimental, randomizado del tipo ensayo-clínico, tuvo como objetivo identificar la influencia del baño de inmersión en la duración del primer período clínico del parto y en la frecuencia y duración de las contracciones uterinas. Los datos fueron recolectados en una maternidad pública filantrópica de la ciudad de São Paulo que atiende, en promedio, 1,100 partos mensuales. La muestra constó de 108 parturientas, 54 en el grupo control y 54 en el experimental, que hicieron uso del baño de inmersión. Los resultados demostraron que el baño de inmersión no modificó la duración del trabajo de parto y la frecuencia de las contracciones uterinas. Entre tanto, la duración de las contracciones fue estadísticamente menor en el grupo experimental (41,9 versus 44,6min. Se concluye que el baño de inmersión es una alternativa para el confort de la mujer, durante el trabajo de parto, por ofrecer alivio a la parturienta, sin interferir en la progresión del parto y ocasionar

  19. Duração e fatores associados ao aleitamento materno em crianças menores de 24 meses de idade no estado de Pernambuco Duration and associated factors to breastfeeding among children under 24 months in the state of Pernambuco

    Directory of Open Access Journals (Sweden)

    Maria Gorete Lucena de Vasconcelos

    2006-03-01

    Full Text Available OBJETIVOS: avaliar a duração do aleitamento materno em crianças menores de 24 meses de idade no estado de Pernambuco e verificar a associação de fatores com o aleitamento materno total. MÉTODOS: corte transversal com 852 crianças até 24 meses de idade que fizeram parte da amostra de 2078 menores de cinco anos selecionada para a II Pesquisa Estadual de Saúde e Nutrição. Os dados foram coletados no período de fevereiro a maio de 1997. Utilizou-se a análise de sobrevivência para cálculo da mediana do aleitamento materno e das associações com a situação do domicílio, renda per capita, escolaridade materna, consultas no pré-natal, orientação sobre aleitamento materno, tipo de parto e peso ao nascer. RESULTADOS: através de análise de sobrevivência verificou-se que a duração mediana do aleitamento materno exclusivo, predominante e total foi de 24, 77 e 112 dias, respectivamente. A duração mediana do aleitamento materno total foi significantemente mais prolongada entre as crianças que residiam na Região Metropolitana do Recife (148 dias, cujas mães percebiam um rendimento familiar per capita acima de dois salários mínimos (201 dias, que haviam freqüentado seis ou mais consultas no pré-natal (129 dias e recebido orientação sobre aleitamento materno durante o pré-natal (126 dias. O peso ao nascer, a alfabetização materna e o tipo de parto não influenciaram significativamente o aleitamento total. CONCLUSÕES: verificou-se um crescimento na duração do aleitamento materno em Pernambuco, particularmente na Região Metropolitana do Recife, demonstrando ser o pré-natal um dos fatores de oportunidade para orientar e incentivar às mães a amamentarem seus filhos.OBJECTIVES: to assess breastfeeding time in children under 24 months old and determine factors associated to exclusive breastfeeding in the State of Pernambuco. METHODS: cross sectional study of 852 children aged 24 months old and younger within a sample of

  20. Development of raw materical iron-removal process and automatic additive adding system for high quality silica bricks production%优质硅砖生产中原料除铁工艺及添加剂自动添加系统的研发

    Institute of Scientific and Technical Information of China (English)

    白城; 吴占德; 柏杉

    2014-01-01

    To increase yield and performance indicators and decrease product energy consumption, the key parts and equipment in production of silica bricks which can easily effect product perform-ances and yield were studied. Furthermore,with reference to domestic and international advanced technologies,the raw materical iron-removal process and automatic added system for additives and mineralizers were developed and a best technical program was determined for the production of high quality silica bricks to optimize product quality and minimize the energy consumption.%为提高硅砖的成品率和性能指标,进一步降低产品能耗,研究了硅砖生产过程中容易影响制品性能和成品率的关键环节和设备,并参考国内外先进技术,研发出原料除铁工艺及添加剂、矿化剂自动添加系统,确定了优质硅砖生产线相应环节的最佳技术方案,最大限度地提高了成品质量并降低能耗。

  1. Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system

    DEFF Research Database (Denmark)

    Eftekhari, Sajedeh; Warfvinge, Karin; Blixt, Frank W;

    2013-01-01

    Primary headaches such as migraine are postulated to involve the activation of sensory trigeminal pain neurons that innervate intracranial blood vessels and the dura mater. It is suggested that local activation of these sensory nerves may involve dural mast cells as one factor in local inflammation......, causing sensitization of meningeal nociceptors. Immunofluorescence was used to study the detailed distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in whole-mount rat dura mater...

  2. Microscopic morphology and histology of the human meninges.

    Science.gov (United States)

    Weller, R O

    2005-03-01

    The meninges comprise the dura mater and the leptomeninges (arachnoid and pia mater). Dura forms an outer endosteal layer related to the bones of the skull and spine and an inner layer closely applied to the arachnoid mater. Leptomeninges have multiple functions and anatomical relationships. The outer parietal layer of arachnoid is impermeable to CSF due to tight intercellular junctions; elsewhere leptomeningeal cells form demosomes and gap junctions. Trabeculae of leptomeninges compartmentalize the subarachnoid space and join the pia to arachnoid mater. In bacterial meningitis leptomeningeal cells secrete cytokines. Pia mater is reflected from the surface of the brain and spinal cord onto arteries and veins, thus separating the subarachnoid space from the brain and cord. A sheath of leptomeninges accompanies arteries into the brain and is related to the pathways for the drainage of interstitial fluid that play a role in inflammatory responses in the brain and appear to be blocked by amyloid-beta in Alzheimer's disease. Specialised leptomeningeal cells in the stroma of the choroid plexus form collagen whorls that become calcified with age. Leptomeningeal cells also form channels in the core and apical cap of arachnoid granulations for the drainage of CSF into venous sinuses. In the spine, leptomeninges form highly perforated intermediate sheets of arachnoid and delicate ligaments that compartmentalize the subarachnoid space; dentate ligaments anchor subpial collagen to the dura mater and stabilize the spinal cord. Despite the multiple anatomical arrangements and physiological functions, leptomeningeal cells retain many histological features that are similar from site to site.

  3. Tentorial and dural calcification with tertiary hyperparathyroidism: a rare entity in chronic renal failure

    Energy Technology Data Exchange (ETDEWEB)

    Dorenbeck, U.; Bretschneider, T.; Feuerbach, S. [Department of Diagnostic Radiology, University Hospital of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg (Germany); Leingaertner, T.; Kraemer, B.K. [Department of Internal Medicine II, University Hospital of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg (Germany)

    2002-07-01

    A case of rare calcification of the tentorium cerebelli, the thoracal dura mater of the spine, and the sclera in an adult male patient with tertiary hyperparathyroidism is presented. The often reported feature in the skull is that of a combination of osteopenia and osteosclerosis giving a granular bone texture. Extensive dura calcification with this condition has very rarely been reported. It is the aim of this paper to document the latter in a patient with chronic renal failure and tertiary hyperparathyroidism. (orig.)

  4. Duração do aleitamento materno em menores de dois anos de idade em Itupeva, São Paulo, Brasil: há diferenças entre os grupos sociais? Breast feeding duration in children under two years of age in Itupeva, São Paulo, Brazil: are there differences among social groups?

    Directory of Open Access Journals (Sweden)

    Elizabeth Fujimori

    2010-03-01

    Full Text Available OBJETIVOS: conhecer a duração do aleitamento materno (AM total e os determinantes associados à sua interrupção segundo perfis de reprodução social das famílias (formas de trabalhar e viver, fundamentados na teoria da determinação social do processo saúde-doença. MÉTODOS: estudo transversal conduzido em uma amostra de 261 crianças menores de dois anos, residentes em Itupeva, São Paulo, Brasil. A partir de uma base teórico-metodológica-operacional compuseramse três grupos sociais homogêneos (GSH segundo semelhantes formas de trabalhar e de viver. A duração do AM total foi estimada com a técnica de tábuas de vida. O teste de Wilcoxon foi empregado para identificar associação entre as variáveis categóricas na análise bivariada. Para análise múltipla, as variáveis associadas com a duração mediana do AM (pOBJECTIVE: based on the theory of social determination of the health-disease process, the objective of this study was to know the duration of overall breast feeding and the factors associated with its interruption, according to the social reproduction profiles of the families (ways of living and working. METHODS: this is a cross-sectional study carried out with a representative sample of 261 children under two years of age, living in Itupeva city, Sao Paulo, Brazil. From a theoretical-methodologicaloperational basis, three social homogeneous groups (GSH were established, according to similar conditions of working and living. Overall breast feeding duration was calculated from survival tables. Variables with p<0.20 in bivariate Wilcoxon test were then introduced in multiple Cox Regression model in order to find associated aspects to the breast feeding duration. RESULTS: the breast feeding duration medians of the 3 GSH were 6.7 months, 7.1 months and 9.9 months, with no statistically significant difference (p=0.31. The multivariate analysis showed that the sequence of birth (p=0.018, pacifier use (p<0.001 and bottle

  5. A influência do ruído ambiental no desempenho de escolares nos testes de padrão tonal de frequência e padrão tonal de duração Environmental noise influence on student performance in the Frequency Pattern Tests and Duration Pattern Tests

    Directory of Open Access Journals (Sweden)

    Ludimila Souza Nascimento

    2012-06-01

    Full Text Available OBJETIVO: caracterizar o desempenho de escolares nos testes de padrão tonal de frequência e padrão tonal de duração no silêncio e na presença de ruído ambiental. METODO: trata-se de estudo experimental transversal, com amostra de conveniência, composta por 70 estudantes, que responderam a um formulário de percepção do ruído ambiental. O nível de ruído da escola foi avaliado com medidor de nível de pressão sonora. Os estudantes foram submetidos à avaliações (fala, motricidade orofacial, linguagem e simplificada do processamento auditivo e distribuídos em dois grupos (G1 sem alteração fonoaudiológica e G2 com alteração fonoaudiológica. Foram realizados também os testes de padrão tonal de frequência e duração (silêncio e ruído. RESULTADOS: o nível médio de pressão sonora da escola variou de 57,2 dB(A na sala de informática a 83,6 dB(A na quadra de esportes. Segundo os estudantes, o que mais interfere em suas atividades é o barulho de conversas durante a aula. Quanto aos testes de padrão tonal de frequência (TPF e duração (TPD, observou-se que a média de acertos no ambiente silencioso foi maior que no ambiente ruidoso. O G1 apresentou melhor desempenho no TPD e TPF que G2. No ruído houve piora no desempenho dos dois grupos (G1 e G2 nos testes. CONCLUSÃO: os níveis de pressão sonora da escola encontram-se elevados e fora do padrão recomendado pelas normas nacionais. No ruído, houve piora no desempenho dos testes nos dois grupos estudados.PURPOSE: to characterize student performance in Frequency Pattern Test (FPT and Duration Pattern Test (DPT in a silent ambient and under noise. METHOD: experimental cross-sectional study, measured in a convenience sample. Survey made up by 70 students who answered a form on their noise perception. School's noise level was evaluated using physical measurements. Students were submitted to previous evaluations (speech, language, and auditory processing and then splinted

  6. Densidade e sistema de espaçamento de bananeiras ‘Nanicão’: duração do ciclo e do período de colheita Density and spacing system of ‘Nanicão’ bananas: duration of cycle and period of harvest

    Directory of Open Access Journals (Sweden)

    Ricardo Alfredo Kluge

    1999-10-01

    Full Text Available O trabalho teve como objetivo verificar a influência de diferentes densidades e sistemas de espaçamento sobre a duração do ciclo e do período de colheita de bananeiras ‘Nanicão’, em Piracicaba (SP. Quatro densidades (1333; 1666; 2222 e 3333 plantas/ha e dois sistemas de espaçamento (retângulo e losango foram avaliados durante as quatro primeiras produções. O sistema de espaçamento teve pouco efeito sobre a duração do ciclo e do período de colheita, enquanto que, a partir da segunda safra, estes períodos foram maiores à medida que a densidade aumentou. Na densidade 3333 plantas/ha, a soma dos quatro ciclos atingiu 55,1 meses, enquanto que nas demais densidades este período foi reduzido para 50,1 meses (2222 plantas/ha, 47,7 meses (1666 plantas/ha e 45,9 meses (1333 plantas/ha. A colheita do primeiro ciclo foi realizada em quatro meses para todas as densidades. No segundo ciclo, a colheita dos plantios mais densos (2222 e 3333 plantas/ha foi realizada em oito meses, diminuindo para sete meses, com 1666 plantas/ha, e para seis meses com 1333 plantas/ha. No terceiro ciclo, a duração da colheita na maior densidade aumentou para 11 meses, enquanto que nas demais densidades a colheita processou-se em 10, 9 e 8 meses (2222; 1666 e 1333 plantas/ha, respectivamente. No quarto ciclo a colheita foi efetuada em 14; 12; 12 e 8 meses, para as densidades de 3333; 2222; 1666 e 1333 plantas/ha, respectivamente.The objective of this work was to verify the influence of the density and spacing systems on the duration of the cycle and period of harvest of the ‘Nanicão’ banana, planted in Piracicaba, SP, Brazil. Four densities (1333; 1666; 2222 and 3333 plants/ha and two spacing systems (rectangle and diamond were evaluated for the first four crops. The spacing system had little effect on duration of cycle and period of harvest, while after the second cycle, the harvest period increased with plant density. At the density of 3333 plants

  7. Leaf life span and nitrogen content in semideciduous forest tree species (Croton priscus and Hymenaea courbaril Duração da vida da folha e conteúdo de nitrogênio em espécies arbóreas (Croton priscus e Hymenaea courbaril de floresta semidecídua

    Directory of Open Access Journals (Sweden)

    Claudia Regina Baptista Haddad

    2004-01-01

    Full Text Available In comparison to deciduous species, evergreen plants have lower leaf nutrient contents and higher leaf life span, important mechanisms for nutrient economy, allowing the colonization of low fertility soils. Strategies to conserve nitrogen in two semideciduous tropical forest tree species, with different leaf life spans were analyzed. The hypothesis was the fact that the two species would present different nitrogen conservation mechanisms in relation to chemical (total nitrogen, protein, chlorophyll, and proteolytic activity, functional (leaf life span, N-use efficiency, and N-resorption efficiency, morphological (specific leaf mass leaf characteristics, and total nitrogen in the soil. Hymenaea courbaril L. presented lower nitrogen compounds in leaves, longer leaf life span, higher N-use efficiency, and higher specific leaf mass, while absorbing proportionally less nitrogen from the soil than Croton priscus Croizat. These characteristics can contribute for a better nitrogen economy strategy of H. courbaril. No relationship was found between leaf life span and N resorption efficiency, nor between leaf life span, protease activity and nitrogen mobilization. The electrophoretic profiles of proteolytic enzymes in young leaves of the two species presented more bands with enzymatic activity than other kinds of leaves.Comparadas a espécies decíduas, as sempre-verdes têm menos nutrientes nas folhas, que também são mais longevas. Estes mecanismos são importantes para economia de nutrientes, e permitem a colonização de solos com baixa fertilidade. Foram analisadas estratégias de conservação de nitrogênio em duas espécies de floresta semidecídua, que aparentemente apresentavam longevidades foliares diferentes. Para isto foram comparados mecanismos químicos (concentrações de nitrogênio total, de proteína e clorofila e atividade proteolítica, funcionais (duração de vida das folhas, eficiência do uso de nitrogênio e eficiência de

  8. Application of COMPONT Medical Adhesive Glue for Tension-Reduced Duraplasty in Decompressive Craniotomy

    Science.gov (United States)

    Zhou, Yujia; Wang, Gesheng; Liu, Jialin; Du, Yong; Wang, Lei; Wang, Xiaoyong

    2016-01-01

    Background The aim of this study was to evaluate the application of medical adhesive glue for tension-reduced duraplasty in decompressive craniotomy. Material/Methods A total of 56 cases were enrolled for this study from Jan 2013 to May 2015. All patients underwent decompressive craniotomy and the dura was repaired in all of them with tension-reduced duraplasty using the COMPONT medical adhesive to glue artificial dura together. The postoperative complications and the healing of dura mater were observed and recorded. Results No wound infection, epidural or subdural hematoma, cerebrospinal fluid leakage, or other complications associated with the procedure occurred, and there were no allergic reactions to the COMPONT medical adhesive glue. The second-phase surgery of cranioplasty was performed at 3 to 6 months after the decompressive craniotomy in 32 out of the 56 cases. During the cranioplasty we observed no adherence of the artificial dura mater patch to the skin flap, no residual COMPONT glue, or hydropic or contracture change of tissue at the surgical sites. Additionally, no defect or weakening of the adherence between the artificial dura mater patch and the self dura matter occurred. Conclusions COMPONT medical adhesive glue is a safe and reliable tool for tension-reduced duraplasty in decompressive craniotomy. PMID:27752035

  9. Avaliação eletromiográfica do músculo masseter em pessoas com paralisia facial periférica de longa duração Masseter muscle electromyographic assessment in subject with long lasting facial palsy

    Directory of Open Access Journals (Sweden)

    Adriana Rahal

    2007-06-01

    Full Text Available OBJETIVO: verificar a atividade elétrica do músculo masseter em pessoas com paralisia facial periférica de longa duração. MÉTODOS: participaram deste estudo seis sujeitos de ambos os sexos, com paralisia facial há pelo menos doze meses, sem queixas mastigatórias e sem disfunção temporomandibular e com pelo menos seis dentes em cada hemiarcada. Todos preencheram um questionário de anamnese e em seguida foram submetidos à eletromiografia de superfície dos masseteres de ambos os lados. As provas eletromiográficas foram: posição habitual com lábios fechados, apertamento dentário, mastigação habitual e unilateral à direita e à esquerda com uva passa. RESULTADOS: em todas as provas eletromiográficas não foram observadas diferenças significantes (p=0,05 entre os lados com e sem paralisia facial. CONCLUSÃO: observou-se com o presente estudo que a força do músculo masseter não sofre influência da paralisia facial de longa duração.PURPOSE: to check the masseter electrical activity in long lasting facial paralysis patients. METHODS: six subjects, with facial paralysis for over a period of twelve months, males and females, took part in this study. Patients should not show any masticatory complaints or have any diagnoses of temporo-mandibular joint dysfunction, having at least six teeth in each half dental ridge. All subjects filled out a questionnaire regarding oral habits and were assessed by surface electromyography of the masseter muscle of both sides. Electromyographic records were taken with lips closed at rest, teeth tightness, besides usual mastication, and unilateral mastication on both sides with raisins. RESULTS: in all electromyographic tests there were no statistically significant differences (p=0.05 between both sides, with and without facial paralysis. CONCLUSION: it was observed that the strength of the masseter muscle is not under the influence of long lasting facial paralysis.

  10. Rota Perilexical na Leitura em Voz Alta: Tempo de Reação, Duração e Segmentação na Pronúncia Perilexical Processing During Reading Performance: Effects Upon Reaction Time, Duration and Segmentation of Utterances

    Directory of Open Access Journals (Sweden)

    Fernando César Capovilla

    2001-01-01

    Full Text Available Conforme o modelo de leitura por dupla rota, na rota lexical a pronúncia é resgatada como um todo a partir do léxico, mas, na perilexical, é construída por segmentos silábicos. Esta análise computadorizada da leitura em voz alta de 270 pseudopalavras por 44 universitários avaliou proporção de acertos, tempo de reação, duração e freqüência de segmentação da pronúncia. Resultados revelaram que: 1 quanto mais curtas e simples as sílabas, mais rápida e segmentar a leitura perilexical; 2 quanto maior o número dessas sílabas, menor a velocidade, mas maior a segmentação; 3 dígrafos diminuem acertos e segmentação, e aumentam duração e tempo de reação; 4 dígrafos aumentam o tempo de reação só quando estão nas primeiras sílabas; 5 este tempo cresce dos grafemas simples aos encontros consonantais aos dígrafos. Tais achados ampliam a validade e complexidade do modelo e a compreensão dos processos seriais e paralelos envolvidos na rota perilexical.According to dual-route reading models, in the lexical route pronunciation is retrieved as a whole from the lexicon, whereas in the perilexical route, it is constructed via phonological decoding of syllabic segments. The study assessed perilexical reading aloud of 270 isolated non-words by 44 college students. A computer analyzed error frequency and temporal parameters of pronunciation: reaction time (RT, duration, and segmentation frequency, as function of non-word characteristics. Results showed that: 1 the shortest and simplest syllables produced the highest reading speed and segmentation frequency; 2 the longest non-words produced the highest segmentation frequency, but the lowest reading speed; 3 digraphs increased error frequency, as well as duration and RT, but decreased segmentation frequency; 4 digraphs (two letters: one phoneme increased RT only when they occurred in the initial syllables; 5 digraphs produced greater RT than did consonantal combinations (two letters

  11. Determinação da curva volume versus duração por meio da distribuição do valor extremo generalizada para estimativa do volume de espera em reservatórios = Determination of volume duration curve by generalized extreme value distribution to estimate waiting water volume in reservoirs

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available Nos reservatórios de usos múltiplo de água, existe conflito para o controle de cheias, principalmente para a geração de energia elétrica. Para controlar cheias é necessário um volume vazio capaz de absorver uma eventual cheia sem causar danos nas áreas à jusante. Por outro lado, para gerar energia é desejável alocar o menor volume de proteção possível, ao passo que para controlar cheias é desejável ter uma estimativa confiável da possibilidade do reservatório falhar quando um dado volume de proteção é alocado. O objetivo deste trabalho foi construir a Curva Volume x Duração, empregada para estimar volume de espera, através do ajuste das séries de volumes máximos afluentes usando a distribuição GEV e momentos LH. Foram usados volumes afluentes observados em várias estações fluviométricas de rios do estado do Paraná, Brasil. Todos os ajustes dos volumesmáximos afluentes foram aceitos através do teste de qualidade de ajuste proposto por Wang (1998. A curva volume x duração foi adequadamente construída usando valores de volumes máximos afluentes observados em diferentes estações fluviométricas.In the reservoirs of multiple uses of water, exist conflict to control floods, mainly for generation of electric energy. To control floods it's necessary an empty volume able to absorb an accidental flood without causing damage in the areas downstream. On the other side, to generate energy it's desirable to place the smallest volume of possible protection, whereas to control floods it's desirable to have a reliable estimate in case the reservoir fails when a given volume of protection is placed. The objective of this work was to construct the Volume Curve x Length, used to estimate the waiting volume, through the adjustments of the series of the affluent maximum volume using the distribution GEV and moments LH. Affluent volumeswere used and observed in several fluviometrics stations of rivers in Paraná state, Brazil

  12. Posição socioeconômica e duração do benefício por incapacidade devido a doenças musculoesqueléticas relacionadas ao trabalho Socioeconomic position and duration of disability benefit due to work-related musculoskeletal disorders

    Directory of Open Access Journals (Sweden)

    Norma Suely Souto Souza

    2012-02-01

    Full Text Available Neste estudo, estima-se o efeito da posição socioeconômica sobre a duração dos benefícios por incapacidade devido a doenças musculoesqueléticas. Dados de um inquérito conduzido pela Auditoria Regional do Instituto Nacional do Seguro Social, com todos os segurados que receberam benefício por incapacidade temporária por doenças musculoesqueléticas da região cervical e membros superiores, em 2008, juntamente com os registros administrativos, foram utilizados para formar uma coorte de 563 trabalhadores. Todos eram residentes em Salvador, Bahia. Entre os trabalhadores sindicalizados e com alta demanda psicossocial no trabalho, a posição socioeconômica se associava positivamente com a duração do benefício (RR = 1,89; IC95%: 1,25-2,87. Esses resultados correspondem ou a uma situação de iniquidade ou ao uso desnecessário do seguro pelos trabalhadores com posição socioeconômica alta. Investigações futuras que visem a elucidar as diferenças na utilização dos benefícios são necessárias para subsidiar a abordagem apropriada dessa questão pelos gestores do seguro social.This study estimated the effect of socioeconomic position on the duration of disability benefits due to musculoskeletal disorders affecting the neck and/or upper limbs. A cohort study including 563 insured workers from the city of Salvador, Bahia, Brazil, registered inthe General Social Security System and who received temporary disability benefits due to musculoskeletal disorders affecting the neck and/or upper limbs, , was performedin 2008 using data from the National Social Security Institute. The results show that among union member workers with high psychosocial demands at work, those with low socioeconomic status are almost twice as likely to receive benefit for a shorter period of time compared to those with a higher socioeconomic position (RR = 1.89; 95%CI: 1.25-2.87. These results reveal aninequitable situation or unnecessary use of insurance for

  13. Test post-weaning duration for performance, feed intake and feed efficiency in Nellore cattle Duração do período de avaliação pós-desmame para medidas de desempenho, consumo e eficiência alimentar em bovinos da raça Nelore

    Directory of Open Access Journals (Sweden)

    André Michel de Castilhos

    2011-02-01

    Full Text Available This study was conducted to determine optimum test duration for measuring performance, feed intake and feed efficiency. Sixty young Nellore bulls were submitted to feeding performance test and fed in individual pens to determine feed intake and performance over 112 days. Body weight was determined every 28 days, after fasting of water and feed for 16 hours. Changes in variance, relative variance and Pearson and Spearman correlations among data from shortened test periods (28, 56 and 84 days and full test period (112 days were used to determine optimum test duration. Test duration for average daily gain, dry matter intake, feed:gain ratio and residual feed intake could be shortened to 84, 28, 84 and 84 days, respectively, without reducing significantly the reliability of measurements for animals fed in individual pens.O objetivo neste estudo foi determinar o melhor período de avaliação para medidas de desempenho, consumo e eficiência alimentar. Durante 112 dias, 60 machos da raça Nelore, recém-desmamados, submetidos à prova de ganho de peso, foram alimentados em baias individuais para determinação do consumo alimentar e do desempenho. O peso corporal dos animais foi determinado a cada 28 dias, depois de jejum de 16 horas de líquidos e sólidos. As alterações na variância, variância relativa e correlações de Pearson e Spearman entre os dados dos períodos de avaliação reduzidos (28, 56 e 84 dias e período total (112 dias foram usados para determinar a melhor duração do período de avaliação. A duração do período de avaliação para ganho médio diário, consumo de matéria seca, conversão alimentar e consumo alimentar residual pode ser reduzida para 84, 28, 84 e 84 dias, respectivamente, pois tal redução não diminui significativamente a confiabilidade das avaliações em animais alimentados em baias individuais.

  14. The Valsalva maneuver duration during labor expulsive stage: repercussions on the maternal and neonatal birth condition Duração da manobra de Valsalva durante o período expulsivo do parto: repercussões maternas e nas condições neonatais de nascimento

    Directory of Open Access Journals (Sweden)

    Andrea Lemos

    2011-02-01

    Full Text Available OBJECTIVES: This cross-sectional study was designed to examine the effects of the Valsalva Maneuver (VM and its duration on the acid- base equilibrium of the neonate and its maternal repercussions during the expulsive stage of labor, after standard breathing and pushing instructions were given. METHODS: A convenience sample of women with low risk pregnancy (n=33; mean age 22.5±3.7y and gestational age 38.1±1.12wks and their newborns were studied during the expulsive stage of vaginal labor. Coaching consisted of standard recommendations for breathing including prolonged VMs coordinated with pushing. Maternal outcomes included the need for uterus fundal pressure maneuver and episiotomy, perineal trauma and posture. Neonatal outcomes included blood gases sampled from the umbilical cord, and Apgar scores. Data were analyzed with the Fisher's exact test, chi-square test, and Pearson correlation coefficient. RESULTS: None of the maternal outcomes were associated with VM duration. With respect to neonatal outcomes, increased VM duration was associated with reduced venous umbilical pH (r=-0.40; p=0.020, venous base excess (r=-0.42; p=0.014 and with arterial base excess (r=-0.36; p=0.043. Expulsive stage time was negatively associated with umbilical venous and arterial pH. CONCLUSIONS: VM duration during fetal expulsion in labor negatively affects fetal acid-base equilibrium and potentially the wellbeing of the neonate. Our results support the need to consider respiratory strategies during labor, to minimize potential risk to the mother and neonate.OBJETIVOS: O presente estudo de corte transversal teve como objetivo avaliar os efeitos da Manobra de Valsalva (MV e sua duração no equilíbrio ácido-básico fetal e nas repercussões maternas durante o período expulsivo do parto, após instrução respiratória padronizada. MÉTODOS: Uma amostra de conveniência em gestantes de baixo risco (n=33, média de idade 22,5±3.7 anos e idade gestacional 38.1

  15. Curvas Intensidade-Duração-Frequência das precipitações extremas para o município de Cuiabá (MT / Intensity-Duration-Frequency Curves of extreme precipitation for the city of Cuiabá (MT

    Directory of Open Access Journals (Sweden)

    Ana Letícia Pilz de Castro

    2011-08-01

    Full Text Available Para a elaboração de projetos na área de drenagem urbana, o conhecimento adequado das precipitações máximas, que são normalmente determinadas a partir de relações Intensidade-Duração-Frequência, é muito importante. O presente trabalho apresenta um estudo para a obtenção da equação IDF para o município de Cuiabá, capital do Estado de Mato Grosso. Os dados utilizados no trabalho foram registrados por estação climatológica localizada em Várzea Grande (MT, com série histórica de 25 anos.AbstractIn order to develop projects in the urban drainage area, it is very important to be aware of adequate maximum rainfall, which is usually determined from relations among Intensity-Duration-Frequency. This paper presents a study to obtain the IDF equation for the Cuiaba city located in Mato Grosso State. The data used in the study were recorded by climatological station, located in Varzea Grande (MT with historical series during 25 years.

  16. Efeito da Duração do Período de Jejum Pré-Abate Sobre Rendimento de Carcaça e a Qualidade da Carne do Peito de Frangos de Corte Effect of Feed and Water Withdrawal on Carcass Yield and Breast Meat Quality of Broilers

    Directory of Open Access Journals (Sweden)

    JC Denadai

    2002-05-01

    Full Text Available O objetivo de estudo foi o de avaliar o efeito do jejum de ração e água antes do abate sobre o rendimento de carcaça e cortes, perda de peso vivo, conteúdo do papo, intestino e moela, matéria seca das fezes, bem como volume globular médio e proteína total plasmática do soro. Foram utilizados 600 pintos machos da linhagem Ross, criados até 42 dias de idade, quando foram submetidos a três períodos de jejum (zero, quatro ou oito horas. A duração do período de jejum afetou (p0,05 do período de jejum sobre as demais variáveis estudadas.The objective of this estudy was to evaluate the effect of feed and water withdrawal on carcass yield and parts, body weight loss, content of crop, gizzard and intestine, dry matter content of faeces and breast meat quality, as well as plasma total protein and packed cell volume. Six hundred day-old Ross chicks were reared until 42 days of age when they were submited to one of three feed withdrawal period (0, 4 or 8 hours. Feed withdrawal period affected (p0.05 of feed withdrawal period on the other variables evaluated.

  17. Alma mater NYC : võimenda, kiirenda, kuhja / Mariliis Lilover

    Index Scriptorium Estoniae

    Lilover, Mariliis

    2014-01-01

    Mariliis Liloveri arhitektuurialastest õpingutest New Yorgis (Graduate School of Architecture, Planning and Preservation at Columbia University) ja tema arvamusest, et koolide ülesandeks on koolitada selline arhitekt, kelle eesmärk peaks olema ületada nii iseennast kui ka tellija unistusi, kavandades midagi, mida klient algul ei osanud soovida, kuid usub lõpuks, et just sellisest tulemusest ta unistaski

  18. Domestic Waterway Transportation Mater A Case In Vietnam

    Directory of Open Access Journals (Sweden)

    Xuan Nam Chu

    2015-08-01

    Full Text Available Vietnams shipping fleet is in a state of surplus of small-tonnage vessels composite cargo vessels while there is a lack of large-scale vessels running international routes and specialized ships carrying cement chemicals and gas. Liquefied. With such a fleet structure the domestic fleet only accounts for 10-12 of the import and export market of which the combined dry bulk market share accounts for 12 containerized cargo accounts for 8. liquid cargo accounts for 8. The export market of the Vietnamese fleet is mainly China Southeast Asia Asia some ships have exported to Eastern Europe but in very small quantity. Some Vietnamese ship owners have large vessels such as Container Vinalines Company East Sea Transportation Company Gemadept Corporation Vietnam Shipping Joint Stock Company have ship to Europe and North America. Most of the dry bulk carriers mainly containerized feeder feeder ships are used in Singapore and Hong Kong while other major markets such as the Americas are owned by foreign shipping lines. The reason for the low market share of Vietnamese shipping is primarily due to subjective factors such as improper fleet structure The technical condition is weak the ship is detained many times abroad The organization of management of service delivery of Vietnamese enterprises is weak lack of linkage between ships cargo owners trade and insurance Difficult financial resources Weak and lack of human resources The habit of buying CIF selling FOB lost the opportunity to rent a means. In addition due to some objective reasons such as the global financial crisis Oil prices fuel prices are unstable and continuously rising The mechanism of government policy is lacking and incomplete.

  19. The Marriage of Alma Mater to Adam Smith.

    Science.gov (United States)

    Buescher, John B.

    1987-01-01

    Businesses and universities must be encouraged to act from their traditional positions of strength, based on the longest view and the broadest interests. They must examine carefully their potential sources of conflict as well as opportunities for benefit before engaging in alliances that may become complex and difficult to manage. (MSE)

  20. Teacher History: Student Historians, Faculty Biographies, and the "Alma Mater"

    Science.gov (United States)

    Stofferahn, Steven A.

    2009-01-01

    When his department chair asked him a few years ago to take over as faculty advisor to their university's chapter of the Phi Alpha Theta history honor society, the author readily accepted. Not only would it provide a great opportunity to get to know some of their best students better, it would also help a junior faculty member like himself fulfill…

  1. KamLAND-PICO Dark Mater Search Project

    Science.gov (United States)

    Fushimi, K.; Awatani, Y.; Ejiri, H.; Hazama, R.; Ikeda, H.; Imagawa, K.; Inoue, K.; Kozlov, A.; Orito, R.; Shima, T.; Sugawara, R.; Yasuda, K.

    Dark matter search project KamLAND-PICO is proposed. The first phase of the project aims to verifying the annual modulation signal which has been reported by DAMA/LIBRA. The last phase of the project aims to determining the type of interaction between WIMPs and nucleus. The thin and wide area NaI(Tl) detector PICO-LON has been developed to determine the type of WIMPs interaction. The good performance of PICO-LON detector was obtained. The energy threshold was as low as 2 keVee and the the energy resolution was as small as 25% at 60 keVee. The highly pure NaI(Tl) crystal has been developed in collaboration with the Japanese developer. The purity of U and Th chain contaminants have been reduced to the order of a few tens of ppt. It should be remarked that the concentration of 210Pb was reduced to about 60 μBq/kg. The sensitivity to spin-independent WIMPs are discussed by applying 170 modules of NaI(Tl) with the dimension of 5 inch ϕ× 5 inch.

  2. Alma mater NYC : võimenda, kiirenda, kuhja / Mariliis Lilover

    Index Scriptorium Estoniae

    Lilover, Mariliis

    2014-01-01

    Mariliis Liloveri arhitektuurialastest õpingutest New Yorgis (Graduate School of Architecture, Planning and Preservation at Columbia University) ja tema arvamusest, et koolide ülesandeks on koolitada selline arhitekt, kelle eesmärk peaks olema ületada nii iseennast kui ka tellija unistusi, kavandades midagi, mida klient algul ei osanud soovida, kuid usub lõpuks, et just sellisest tulemusest ta unistaski

  3. Beatriz de Portugal y el Hospital Mater Dei de Tordesillas

    OpenAIRE

    Santo Tomás Pérez, Magdalena

    2004-01-01

    Producción Científica El presente trabajo fue presentado en el congreso Portugal e Castela na Idade Média celebrado en la universidade Portucalense Infante D. Henrique, de Porto, Portugal, en el año 2004 y está publicado en Castilla y el Mundo feudal. Homenaje al Profesor Julio Valdeón, obra dirigida por los profesores de la Uva Mª Isabel del Val Valdivieso y Pascual Martínez Sopena y editada por la Junta de Castilla y León y por la Universidad de Valladolid, en el volumen III, pp 4...

  4. Alma mater sõnas, pildis ja helis / Varje Sootak

    Index Scriptorium Estoniae

    Sootak, Varje, 1946-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  5. Ilves nautis oma alma mater'i õhustikku / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    President Toomas Hendrik Ilves ja Gruusia president Mihheil Saakashvili külastasid New Yorgis oma kunagist õpingutepaika Columbia ülikooli. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  6. Saving Alma Mater: A Rescue Plan for America's Public Universities

    Science.gov (United States)

    Garland, James C.

    2009-01-01

    America's public universities educate 80% of our nation's college students. But in the wake of rising demands on state treasuries, changing demographics, growing income inequality, and legislative indifference, many of these institutions have fallen into decline. Tuition costs have skyrocketed, class sizes have gone up, the number of courses…

  7. Alma mater sõnas, pildis ja helis / Varje Sootak

    Index Scriptorium Estoniae

    Sootak, Varje, 1946-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  8. Why is the universe more partial to mater than antimatter?

    CERN Multimedia

    2006-01-01

    "B factory experiments at the Stanford Linear Accelerator (SLAC) in the USA and at the High Energy Accelerator Research Organization (KEK) in Japan have reached a new milestone in the quest to understand the matter-antimatter imbalance in our universe.

  9. The Marriage of Alma Mater to Adam Smith.

    Science.gov (United States)

    Buescher, John B.

    1987-01-01

    Businesses and universities must be encouraged to act from their traditional positions of strength, based on the longest view and the broadest interests. They must examine carefully their potential sources of conflict as well as opportunities for benefit before engaging in alliances that may become complex and difficult to manage. (MSE)

  10. Warm dense mater: another application for pulsed power hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Reinovsky, Robert Emil [Los Alamos National Laboratory

    2009-01-01

    Pulsed Power Hydrodynamics (PPH) is an application of low-impedance pulsed power, and high magnetic field technology to the study of advanced hydrodynamic problems, instabilities, turbulence, and material properties. PPH can potentially be applied to the study of the properties of warm dense matter (WDM) as well. Exploration of the properties of warm dense matter such as equation of state, viscosity, conductivity is an emerging area of study focused on the behavior of matter at density near solid density (from 10% of solid density to slightly above solid density) and modest temperatures ({approx}1-10 eV). Conditions characteristic of WDM are difficult to obtain, and even more difficult to diagnose. One approach to producing WDM uses laser or particle beam heating of very small quantities of matter on timescales short compared to the subsequent hydrodynamic expansion timescales (isochoric heating) and a vigorous community of researchers are applying these techniques. Pulsed power hydrodynamic techniques, such as large convergence liner compression of a large volume, modest density, low temperature plasma to densities approaching solid density or through multiple shock compression and heating of normal density material between a massive, high density, energetic liner and a high density central 'anvil' are possible ways to reach relevant conditions. Another avenue to WDM conditions is through the explosion and subsequent expansion of a conductor (wire) against a high pressure (density) gas background (isobaric expansion) techniques. However, both techniques demand substantial energy, proper power conditioning and delivery, and an understanding of the hydrodynamic and instability processes that limit each technique. In this paper we will examine the challenges to pulsed power technology and to pulsed power systems presented by the opportunity to explore this interesting region of parameter space.

  11. Efeitos agudos de levosimendana e dobutamina na duração do QRS em Pacientes com insuficiência cardíaca Efectos agudos de levosimendana y dobutamina en la duración del QRS en pacientes con insuficiencia cardíaca Acute effects of levosimendan and dobutamine on QRS duration in patients with heart failure

    Directory of Open Access Journals (Sweden)

    Osman Can Yontar

    2010-12-01

    Full Text Available FUNDAMENTO: A levosimendana é um novo agente inotrópico que aumenta a contratilidade cardíaca sem aumentar a captação celular de cálcio, de forma a não causar sobrecarga de cálcio e arritmias relacionadas. Em pacientes com insuficiência cardíaca (IC, a duração prolongada do QRS está associada com um aumento no risco de mortalidade e morte súbita cardíaca. Mudanças estruturais no ventrículo esquerdo podem levar à contração assíncrona, causando atraso de condução e um QRS prolongado no ECG de superfície. OBJETIVO: O objetivo do presente estudo foi comparar os efeitos agudos de levosimendana e dobutamina na duração do QRS em pacientes com IC grave e ritmo sinusal. MÉTODOS: 60 pacientes consecutivos com IC isquêmica foram incluídos no estudo e randomizados em dois grupos para infusão de levosimendana (n=37 ou dobutamina (n=23. 67,2 % eram homens; a média da idade era 66,4 ± 9,2 anos para todos os pacientes. A duração basal do QRS nos grupos levosimendana e dobutamina foi 120,44 ± 23,82 ms vs 116,59 ± 13,80 ms respectivamente. A fração de ejeção do ventrículo esquerdo (FEVE estava diminuída em ambos os grupos (23,15 ± 8,3 vs 24,56 ± 7,5%. RESULTADOS: No grupo levosimendana, a duração do QRS diminuiu do valor basal para 116,47 ± 24,56 ms (p=0,006, enquanto não houve diferença significante no grupo dobutamina (p=0,605. Ambos os medicamentos causaram um aumento na FEVE, mas este foi significante apenas no grupo levosimendana (27,95 ± 8,9% p=0,003 vs 26,67 ± 7,6%, p=0,315. CONCLUSÃO: O estudo sugere que a administração de levosimendana, mas não de dobutamina, encurta a duração do QRS no ECG de superfície, possivelmente por causar uma contração coletiva nas fibras do músculo do ventrículo esquerdo. A base molecular desse efeito ainda precisa ser esclarecida.FUNDAMENTO: La levosimendana es un nuevo agente inotrópico que aumenta la contractibilidad cardíaca sin aumentar la captación celular de

  12. To analyse the effects of massage on severe prolapse of intervertebral discs of the lower back%推拿手法整复重症腰椎间盘突出症的疗效分析

    Institute of Scientific and Technical Information of China (English)

    李加斌

    2001-01-01

    @@ Background: The prolapse of intervertebral disc is not only damage of the local intervertebral disc, but a comprehensive damage tightly related with factors as damages of the pyramidal ligament, nerve, muscle and posterior joints and aseptic inflammation. The dura mater or the nerve root are stimulated, compassed or extracted and ischemia and inflammation caused increased sensitivity.

  13. Testing haptic sensations for spinal anesthesia.

    LENUS (Irish Health Repository)

    2011-01-01

    Having identified key determinants of teaching and learning spinal anesthesia, it was necessary to characterize and render the haptic sensations (feeling of touch) associated with needle insertion in the lower back. The approach used is to match recreated sensations (eg, "pop" through skin or dura mater) with experts\\' perceptions of the equivalent clinical events.

  14. An Apparatus for Collection of Cerebrospinal Fluid in Goats

    Science.gov (United States)

    1988-03-01

    TUBE: Prior to implantation of the cisternal cannula, a hole is trephined down through the base of the occipital bone overlying the dura mater above...through a hole trephined in the parietal bone. It is then supported with stereo-taxic equipment while the dental acrylic cement is applied similarly to

  15. Controlled light field concentration through turbid biological membrane for phototherapy.

    Science.gov (United States)

    Wang, Fujuan; He, Hexiang; Zhuang, Huichang; Xie, Xiangsheng; Yang, Zhenchong; Cai, Zhigang; Gu, Huaiyu; Zhou, Jianying

    2015-06-01

    Laser propagation through a turbid rat dura mater membrane is shown to be controllable with a wavefront modulation technique. The scattered light field can be refocused into a target area behind the rat dura mater membrane with a 110 times intensity enhancement using a spatial light modulator. The efficient laser intensity concentration system is demonstrated to imitate the phototherapy for human brain tumors. The power density in the target area is enhanced more than 200 times compared with the input power density on the dura mater membrane, thus allowing continued irradiation concentration to the deep lesion without damage to the dura mater. Multibeam inputs along different directions, or at different positions, can be guided to focus to the same spot behind the membrane, hence providing a similar gamma knife function in optical spectral range. Moreover, both the polarization and the phase of the input field can be recovered in the target area, allowing coherent field superposition in comparison with the linear intensity superposition for the gamma knife.

  16. Spinal Cord Swelling and Alterations in Hydrostatic Pressure after Acute Injury

    Science.gov (United States)

    2015-10-01

    AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT In Year 1 of this award we examined ...remaining dura mater in a watertight manner using a running suture of 6-0 Prolene, including the use of fibrin sealant to reinforce sutures. Control...4 3.2 Results

  17. Primary acalvaria: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Rios, Livia Teresa Moreira, E-mail: ltlrios@terra.com.b [Universidade Federal do Maranhao (UFMA), Sao Luis, MA (Brazil). Hospital Universitario. Unidade de Diagnostico por Imagem; Martins, Marilia da Gloria [Universidade Federal do Maranhao (UFMA), Sao Luis, MA (Brazil). Hospital Universitario. Servico de Ginecologia e Obstetricia; Simoes, Vanda Maria Ferreira; Nunes, Marynea do Vale; Marques, Patricia Franco; Godoy, Silvia Helena Cavalcante de Souza [Universidade Federal do Maranhao (UFMA), Sao Luis, MA (Brazil). Hospital Universitario. Servico de Neonatologia

    2010-07-15

    Acalvaria is a rare congenital malformation of unknown pathogenesis characterized by the absence of the flat bones of the cranial vault, dura mater and associated muscles, while the central nervous system is usually preserved. The most accepted physiopathogenic theory suggests the presence of a post neurulation defect with normal placement the embryonic ectoderm. The present report describes neonatal imaging findings of primary acalvaria. (author)

  18. Efeitos genéticos e ambientais que afetam a produção de leite e duração da lactação de cabras mestiças no estado da Paraíba Genetic and environmental effects that affect milk production and lactation length of crossbred goats in the state of Paraiba

    Directory of Open Access Journals (Sweden)

    Edgard Cavalcanti Pimenta Filho

    2004-12-01

    Full Text Available Utilizaram-se dados de 689 lactações de 225 cabras Pardo Alpina x Gurguéia filhas de 18 bodes, controladas de 1988 a 1996, criadas na Fazenda Carnaúba, Taperoá-PB, com os objetivos de estudar os efeitos ambientais e estimar parâmetros genéticos para as características produção de leite (PL e duração da lactação (DL. Os efeitos ambientais foram estimados por meio de um modelo estatístico que incluiu o efeito aleatório de bode, os efeitos fixos de grupo contemporâneo, tipo de parto e idade da cabra ao parto e duração da lactação, para PL, como covariáveis. Os parâmetros genéticos foram estimados por intermédio do programa MTDFREML, sob modelo animal, contendo os efeitos fixos e covariáveis utilizados no modelo anterior. As características foram influenciadas pelo efeito fixo de grupo contemporâneo. A idade da cabra influenciou apenas a característica PL. As médias obtidas para PL e DL foram 257,71 ± 54,73 kg e 185,56 ± 46,87 dias, respectivamente, equivalendo à produção média diária de 1,38 kg de leite/dia. As estimativas de herdabilidade e repetibilidade foram, respectivamente, de 0,23 e 0,35 para PL e 0,20 e 0,24 para DL. A correlação genética estimada entre as características foi de 0,96. Em razão de as herdabilidades das características serem de média magnitude e limitadas ao sexo, sugere-se o teste de progênie como método de seleção mais eficaz para os bodes.Records of 689 lactations of 225 Alpine x Gurguéia goats, progenies of 18 buck, controlled from 1988 to 1996, raised at Carnaúba Farm, Taperoá-PB, were analyzed with the objective of study environmental effects and estimate genetics parameters for Milk Production (MP and Length of Lactation (LL. The environmental effects were analyzed by an statistical model that included buck random effects and the fixed effects of contemporary groups, type of kidding and age of dam at kidding and length lactation as covariate. The genetic parameters

  19. Prevalência e duração dos benefícios auxílio-doença decorrentes de asma no Brasil em 2008 Prevalence and duration of social security benefits allowed to workers with asthma in Brazil in 2008

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    Anadergh Barbosa de Abreu Branco

    2012-10-01

    Full Text Available OBJETIVO: Determinar a prevalência e a duração dos benefícios auxílio-doença (BAD decorrentes de asma concedidos pelo Instituto Nacional de Seguro Social aos empregados no Brasil em 2008. MÉTODOS: Estudo descritivo e retrospectivo a partir do banco de dados do Sistema Único de Benefícios sobre os BAD decorrentes de asma concedidos em 2008. A população de referência consistiu da média mensal dos empregados registrados no Cadastro Nacional de Informações Sociais em 2008. Foram estudadas as variáveis ramo de atividade econômica, sexo, idade, tipo e duração dos BAD. A relação trabalho-doença foi avaliada por razão de prevalência (RP entre BAD acidentários e previdenciários. RESULTADOS: Em 2008, foram concedidos 2.483 BAD por asma, com prevalência de 7,5 BAD por 100.000 empregados. A prevalência foi maior em mulheres que em homens (RP = 2,1 entre os sexos. Empregados com > 40 anos tinham 2,5 vezes maior probabilidade de receber BAD por asma do que aqueles com 40 anos e trabalhar nos segmentos de esgoto, fabricação de produtos de madeira e de fabricação de móveis aumentam a probabilidade de afastamento do trabalho por asma.OBJECTIVE: To determine the prevalence and duration of social security benefits (SSBs claims to registered workers with asthma in Brazil by the Brazilian National Institute of Social Security in 2008. METHODS: This was a retrospective, descriptive study, based on information obtained from the Brazilian Unified Benefit System database, on the number of SSB claims granted to registered workers with asthma in 2008. The reference population was the monthly mean number of workers registered in the Brazilian Social Registry Database in 2008. The variables studied were type of economic activity, gender, age, and type/duration of the SSB claim. The relationship between work and asthma was evaluated by the prevalence ratio (PR between work-related and non-work-related SSB claims for asthma. RESULTS: In 2008

  20. Perfluoroctano líquido como tamponante vitreorretiniano de curta duração no pós-operatório de portadores de descolamento de retina por ruptura gigante Perfluoroctane liquid as a short-term vitreous-retinal tamponade in the postoperative period in patients with retinal detachment due to giant tears

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    Marcelo Carvalho Ventura

    2007-06-01

    Full Text Available OBJETIVOS: Relatar os resultados de vitrectomia via pars plana com utilização de perfluocarbono líquido (Perfluoroctano-Ophtalmos®, como tamponante vítreo-retiniano de curta duração, no pós-operatório de portadores de descolamento de retina, por ruptura gigante. MÉTODOS: Estudaram-se dez desses pacientes. Todos os casos eram complicados por vitreorretinopatia proliferativa grau B ou pior com rupturas que variavam em extensão de 90º a 210º. O perfluorocarbono líquido foi introduzido, por via pars plana, com o volume necessário para ultrapassar o limite posterior da ruptura, permanecendo no pós-operatório por cinco dias, estando os pacientes em decúbito dorsal. Após esse período submetiam-se a segunda intervenção para troca do perfluorocarbono líquido para gás ou óleo de silicone. RESULTADOS: Após período de acompanhamento médio de 16,2 ± 12,4 meses (2 a 43 meses, 80% das retinas estavam aplicadas, sendo necessária a repetição desta técnica em 1 caso (10% caso e em 2 casos (20% não houve reaplicação da retina por vitreorretinopatia avançada. Houve melhora da acuidade visual em 5 casos (50%. CONCLUSÃO: Observaram-se bons resultados quanto à aplicação da retina (80% e melhora da acuidade visual (50% quando do uso do perfluorocarbono líquido como tamponante vitreorretiniano de curta duração no pós-operatório de cirurgias de descolamento de retina por rupturas gigantes.PURPOSE: To report pars plana vitrectomy results of intravitreous use of liquid perfluorocarbon as a short-term postoperative tamponade in retinal detachment due to giant tears in a series of patients. METHODS: Ten of those patients, all of them complicated by proliferative vitreoretinopathy grade B or worse, with tear extension varying from 90º to 210º were studied. Perfluorocarbon liquid was injected via pars plana until the posterior tear limit, remaining in the postoperative period during five days, with the patients in supine position

  1. Spatio-temporal modelling of the duration of the cotton cycle in the State Of Goiás, Brazil Modelagem espaçotemporal da duração do ciclo do algodoeiro para o Estado de Goiás

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    Jorge C. dos A. Antonini

    2011-01-01

    Full Text Available The objective of this work was to develop and validate a mathematical model to estimate the duration of cotton (Gossypium hirsutum L. r. latifolium hutch cycle in the State of Goiás, Brazil, by applying the method of growing degree-days (GD, and considering, simultaneously, its time-space variation. The model was developed as a linear combination of elevation, latitude, longitude, and Fourier series of time variation. The model parameters were adjusted by using multiple-linear regression to the observed GD accumulated with air temperature in the range of 15°C to 40°C. The minimum and maximum temperature records used to calculate the GD were obtained from 21 meteorological stations, considering data varying from 8 to 20 years of observation. The coefficient of determination, resulting from the comparison between the estimated and calculated GD along the year was 0.84. Model validation was done by comparing estimated and measured crop cycle in the period from cotton germination to the stage when 90 percent of bolls were opened in commercial crop fields. Comparative results showed that the model performed very well, as indicated by the Pearson correlation coefficient of 0.90 and Willmott agreement index of 0.94, resulting in a performance index of 0.85.O objetivo deste trabalho foi desenvolver e validar um modelo matemático para estimar a duração do ciclo do algodoeiro (Gossypium hirsutum L. r. latifolium hutch no Estado de Goiás, aplicando o método de graus-dia (GD e considerando sua variação espaçotemporal. O modelo foi desenvolvido por meio de combinação linear entre altitude, latitude, longitude e a variação temporal, representada pela série trigonométrica incompleta de Fourier. Os parâmetros do modelo foram ajustados, por meio de regressão linear múltipla, aos dados de GD para o algodoeiro, acumulados entre 15°C e 40°C. Os dados utilizados de temperaturas máxima e mínima foram obtidos de séries históricas de 21 esta

  2. Duração do aleitamento materno, regime alimentar e fatores associados segundo condições de vida em Salvador, Bahia, Brasil Breastfeeding duration, infant feeding regimes, and factors related to living conditions in the city of Salvador, Bahia, Brazil

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    Lucivalda P. Magalhães de Oliveira

    2005-10-01

    Full Text Available Este trabalho tem como objetivo conhecer a duração do aleitamento materno, regime alimentar e fatores associados segundo condições de vida em Salvador, Bahia, Brasil. Este estudo de prevalência envolve 811 crianças menores de 24 meses. Para analisar os dados utilizou-se análise de sobrevivência, qui-quadrado de Pearson e regressão logística. A duração mediana do aleitamento exclusivo, predominante e total foi de 30,6, 73 e 131,5 dias, respectivamente. Identificou-se que 83,3% das crianças tiveram interrupção precoce do aleitamento exclusivo ou predominante. As crianças de famílias com condições de vida consideradas baixas tinham 2,3 vezes mais chances (IC95%: 1,09-5,01 de consumirem alimentos complementares precocemente; essa chance se elevou para 2,5 (IC95%: 1,20-5,34 entre aquelas de famílias com condições de vida muito baixas. A interrupção precoce do aleitamento exclusivo ou predominante associou-se com a maternidade em idade precoce e as precárias condições de vida das crianças e suas famílias. Programas direcionados à promoção da prática adequada do aleitamento materno e adoção da alimentação saudável na infância devem considerar a relevância dos fatores sociais envolvidos no oferecimento precoce de alimentos complementares à criança.This cross-sectional study aimed to identify breastfeeding duration, infant feeding regimes, and factors related to living conditions among 811 children under 24 months of age in Salvador, Bahia, Brazil. Data were statistically analyzed by survival analysis, Pearson's chi-square test, and multivariate logistic regression. Median duration of exclusive, predominant, and total breastfeeding was 30.6, 73.0, and 131.5 days, respectively. Exclusive or predominant breastfeeding was discontinued in 83.6% of the subjects. Children with poor living conditions were 2.3 times more likely (95%CI: 1.09-5.01 to receive early supplementary food, whereas the figure for the very poor

  3. Fatores associados à amnésia pós-traumática de longa duração Fatores asociados a la amnesia post-traumática de larga duración Factors associated with long-term post-traumatic amnesia

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    Silvia Cristina Fürbringer e Silva

    2011-01-01

    Full Text Available OBJETIVO: Identificar fatores relacionados à amnésia pós-traumática de longa duração. MÉTODO: Estudo prospectivo, longitudinal, com 187 vítimas de trauma cranioencefálico contuso, idade >14 anos, atendidos em hospital de referência para trauma. As variáveis independentes foram: idade, sexo, gravidade do trauma cranioencefálico, local e tipo de lesão, número de lesões encefálicas e uso de medicação com atividade em sistema nervoso central ou corticoides. RESULTADO: O modelo de regressão logística múltipla ajustado pela variável área de lesão (intra/extra axial evidenciou: Escala de Coma de Glasgow inicial 3 (OR=2,80 e uso de Fenitoína (OR=2,60, Midazolan (OR=2,83 ou ambas as drogas (OR=3,83. CONCLUSÃO: O uso do Midazolan e da Fenitoína, além da gravidade do trauma cranioencefálico, destacaram-se como fatores relacionados à amnésia de longa duração.OBJETIVO: Identificar factores relacionados a la amnesia post-traumática de larga duración. MÉTODO: Estudio prospectivo, longitudinal, realizado con 187 víctimas de trauma craneoencefálico contuso, edad >14 años, atendidos en un hospital de referencia para trauma. Las variables independientes fueron: edad, sexo, gravedad del trauma craneoencefálico, local y tipo de lesión, número de lesiones encefálicas y uso de medicación con actividad en el sistema nervioso central o corticoides. RESULTADO: El modelo de regresión logística múltiple ajustado por la variable área de lesión (intra/extra axial evidenció: Escala de Coma de Glasgow inicial 3 (OR=2,80 y uso de Fenitoína (OR=2,60, Midazolan (OR=2,83 o ambas drogas (OR=3,83. CONCLUSIÓN: El uso del Midazolan y de Fenitoína, además de la gravedad del trauma craneoencefálico, se destacaron como factores relacionados a la amnesia de larga duración.OBJECTIVE: To identify factors related to post-traumatic amnesia of long duration. METHOD: A prospective, longitudinal study, with 187 victims of blunt head trauma

  4. Clinical Study of Foramen Magnum Decompression with Removal of the Outer Layer of the Dura for Chiari Malformation Associated with Syringomyelia%枕骨大孔减压伴硬膜外层切开术治疗Chiari畸形合并脊髓空洞症的临床研究

    Institute of Scientific and Technical Information of China (English)

    于明军; 洪洋; 刘云会

    2012-01-01

    Objective To investigate the outcomes of foramen magnum decompression with removal of the outer layer of the dura on Chiari malformation with syringomyelia ( ACM-SM) compared with foramen magnum decompression. Methods Thirty patients were performed ( Group A) foramen magnum decompression and thirty-eight patients were performed foramen magnum decompression with removal of the outer layer of the dura( Group B) . In the end, the outcomes were documented and analyzed. Results Short-term effects; at the time of discharge, in group A, 21(70% ) patients achieved an improvement in their clinical symptoms. In Group B, 35(92.1% ) patients achieved an improvement in their clinical symptoms. The outcomes of group B was better than that of group A (P =0.02). Long-term effects:28 patients were followed up in group A, among which 19(67.9% ) patients had an improvement in their clinical symptoms. 33 patients were followed in group B, among which 31 (93. 9% ) patients had an improvement in their clinical symptoms. The outcomes of group B was better than that of group A (P <0.05). MRI showed that in group A, syringomyelia decreased in 20 cases. In group B, syringomyelia decreased in 31 cases. By chi-square test(x2 test) , the syringomyelia got more narrow in group B than that of group A (P < 0.05). Conclusions Operation is an effective treatment for ACM-SM. Different methods should be chosen according to the patients'unique feature. Foramen magnum decompression with removal of the outer layer of the dura is better than foramen magnum decompression in either long-term effects or short-term effects.%目的 探讨枕骨大孔减压伴硬膜外层切开术治疗Chiari畸形合并脊髓空洞症(ACM-SM)的手术疗效.方法 按患者手术方式不同分为两组:A组30例,枕骨大孔减压组;B组38例,枕骨大孔减压伴硬膜外层切开组,回顾性分析两组患者预后情况.结果 近期疗效:出院时,A组有效率70% (21/30),B组有效率92.1%(35/38),二者比

  5. 枕骨大孔减压伴硬膜外层切开术在治疗Chiari畸形Ⅰ型中的应用%Application of Foramen Magnum Decompression with Removal of the Outer Layer of the Dura in Chiari Type I Malformation Treatment

    Institute of Scientific and Technical Information of China (English)

    马维宁; 李春; 张明杰; 李少一

    2012-01-01

    目的 通过临床表现及影像学检查确诊为Chiari畸形的患者,以改善枕大孔区脑脊液循环为目的,采用枕骨大孔减压伴硬膜外层切开的手术方法治疗,随访观察分析手术前后患者临床表现的改善程度,脊髓空洞大小的变化,及其与临床症状改善的相关性.方法 收集整理行枕骨大孔减压伴硬膜外层切开术治疗的45名Chiari畸形Ⅰ型患者的临床症状资料以及MRI检查结果,将患者分为2组,Ⅰ组为不伴有脊髓空洞的Chiari畸形Ⅰ型患者17例,Ⅱ组为伴有脊髓空洞的患者28例,对比手术前后患者临床症状的改善情况,以及手术前后MRI的变化.结果 Ⅰ组患者术后主要临床症状获得明显的缓解,术后均未再次出现临床症状,行MRI复查示小脑扁桃体位置上升,枕大池深度扩大,未出现脊髓空洞.而Ⅱ纽的28例患者中尽管脊髓空洞的大小有不同程度的缩小甚至消失,但由于脊髓空洞导致的常见症状如肢体麻木、疼痛,感觉缺失虽有不同程度的缓解,而像肌肉萎缩,括约肌功能障碍等临床症状几乎无明显改善.结论 枕骨大孔减压伴硬膜外层切除术治疗Chiari畸形Ⅰ型患者有较好疗效;对于Ⅰ组的患者,枕骨大孔减压伴硬膜外层切开术不仅能够使患者得到较高的临床症状缓解率,针对此组患者早期手术极有可能降低脊髓空洞的发生率.%Objective To observe and analyze the change of the clinical manifestation and MRI of Chiari I malformation after the treatment of foramen magnum decompression combined with removal of the outer layer of the dura, and to evaluate the correlation between the therapeutic outcome and the treatment. Methods The patients with Chiari I malformation diagnosed according to their clinical manifestations and MRI were treated with foramen magnum decompression with removal of the outer layer of the dura, and were followed up by our neurological center. Clinical and MRI data

  6. Optic Nerve Sheath Mechanics in VIIP Syndrome

    Science.gov (United States)

    Raykin, Julia; Forte, Taylor E.; Wang, Roy; Feola, Andrew; Samuels, Brian; Myers, Jerry; Nelson, Emily; Gleason, Rudy; Ethier, C. Ross

    2016-01-01

    Visual Impairment Intracranial Pressure (VIIP) syndrome is a major concern in current space medicine research. While the exact pathology of VIIP is not yet known, it is hypothesized that the microgravity-induced cephalad fluid shift increases intracranial pressure (ICP) and drives remodeling of the optic nerve sheath. To investigate this possibility, we are culturing optic nerve sheath dura mater samples under different pressures and investigating changes in tissue composition. To interpret results from this work, it is essential to first understand the biomechanical response of the optic nerve sheath dura mater to loading. Here, we investigated the effects of mechanical loading on the porcine optic nerve sheath.Porcine optic nerves (number: 6) were obtained immediately after death from a local abattoir. The optic nerve sheath (dura mater) was isolated from the optic nerve proper, leaving a hollow cylinder of connective tissue that was used for biomechanical characterization. We developed a custom mechanical testing system that allowed for unconfined lengthening, twisting, and circumferential distension of the dura mater during inflation and under fixed axial loading. To determine the effects of variations in ICP, the sample was inflated (0-60 millimeters Hg) and circumferential distension was simultaneously recorded. These tests were performed under variable axial loads (0.6 grams - 5.6 grams at increments of 1 gram) by attaching different weights to one end of the dura mater. Results and Conclusions: The samples demonstrated nonlinear behavior, similar to other soft connective tissue (Figure 1). Large increases in diameter were observed at lower transmural pressures (approximately 0 to 5 millimeters Hg), whereas only small diameter changes were observed at higher pressures. Particularly interesting was the existence of a cross-over point at a pressure of approximately 11 millimeters Hg. At this pressure, the same diameter is obtained for all axial loads applied

  7. Efeito analgésico de longa duração da dipirona sobre a hiperalgesia persistente induzida pela constrição do nervo ciático em ratos: participação do óxido nítrico Long term analgesic effect of dipyrone on the persistent hyperalgesia induced by chronic constriction injury of sciatic nerve in rats: involviment of nitric oxide

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    Fábio José Reis

    2006-12-01

    Full Text Available O efeito analgésico de longa duração da dipirona foi avaliado em um modelo de dor neuropática assim como a participação da via óxido nítrico-GMPc neste mecanismo analgésico. Uma única administração intraplantar de dipirona (80 µg, no 14º dia após a instalação da hiperalgesia neuropática induzida pela constrição do nervo ciático exerceu um efeito analgésico, significativo e de longa duração. A inibição da óxido nítrico sintetase com L-NAME (50 ou 100 µg/pata, ou do óxido nítrico (NO endógeno com hemoglobina (10 ou 30 µg/pata, bloquearam o desenvolvimento do efeito analgésico da dipirona. A L-arginina (500 µg/pata reverteu o efeito do L-NAME. Cloreto de metiltionínio (azul de metileno (500 µg/pata, ODQ (50 µg/pata (bloqueadores da guanilil ciclase ou glibenclamida (100, 200 ou 300 µg/pata (bloqueador de canais de K+ sensíveis ao ATP inibiram o efeito analgésico da dipirona. O nitroprussiato de sódio administrado no 14º dia após a instalação da hiperalgesia neuropática também exerceu efeito analgésico de longa duração, semelhante ao observado com a dipirona. Sugerimos que a ação analgésica periférica e de longa duração da dipirona, neste modelo experimental, ocorra devido a provável dessensibilização dos nociceptores, envolvendo a via óxido nítrico - GMPc e canais de K+ sensíveis ao ATP.The long term analgesic effect of dipyrone was evaluated on a model of neuropathic pain and the role of nitric oxide/GMPc pathway in this antinociceptive mechanism. One intraplantar dipyrone administration (80 mg, at 14th day after the chronic constriction injury of the sciatic nerve, induced a significant and long term analgesic effect. The inhibition of nitric oxide synthase (NOS with L-NAME (50 or 100 mg/paw or scavenging of the endogenous NO with hemoglobin (10 or 30 mg/paw inhibited the development of the dipyrone analgesia. L-arginine (500 mg/paw could reverted the effect of L-NAME. Metylene blue

  8. Cranioplastia primária nos afundamentos do crânio com ferimento aberto do couro cabeludo Primary cranioplasty in open depressed fractures of the skull

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    Darcy de Freitas Vellutini

    1972-06-01

    Full Text Available Os autores referem 13 casos de afundamentos crânio-encefálicos pós-traumáticos com ferimento aberto do couro cabeludo nos quais foi usado o metilmetacrilato em uma única intervenção cirúrgica. A sede do afundamento era frontal em 9 casos, parietal em dois, parieto-temporal em um e parieto-occipital em um. Os afundamentos interessavam apenas a tábua óssea em 5 casos, estavam associados a lesão de dura-mater em três e também do tecido cerebral em 5. Foi realizada cranioplastia simples em 5 casos e, em 8, ela foi precedida de plástica de dura-mater. O seguimento pós-operatório variou de dois meses a dois anos; até o momento não foi assinalada ocorrência de infecção ou de fenômeno de rejeição da prótese que obrigasse a sua retirada.Thirteen cases of open depressed fractures of the skull in which methyl-methacrylate was primarily used are reported. The site of the depressed fractures was frontal in 9 cases, parietal in two, parieto-temporal in one and parieto-occipital in one. In 5 cases, only the bone was injured; in three cases dura mater was damaged; in 5 cases brain and dura mater were damaged. In 5 cases, only a cranioplasty was performed and in 8 cases a dura mater graft was associated. The follow-up was from two months to two years without any complication as infection or rejection of the methylmethacrylate.

  9. Wartime Writings, or the Imaginary Lover of Marguerite Duras

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    Bethany Ladimer

    2009-01-01

    Full Text Available The publication in 2006 of Marguerite Duras’s Cahiers de la guerre , ‘Wartime Writings,’ written between 1943 and 1949, made accessible to the reader the first known versions of the family drama that was to become the material of much of her fiction. As this work now takes its place as chronologically first in the intertext of Duras’s autofictional writings, it sheds considerable light on our understanding of the transformations in these texts that occurred over her lifetime. Whereas L’Amant had been presented and accepted as the disclosure of a real occurrence and the origin of the other works, it presents several significant aspects of Duras’s life at the time, as well as the lover himself, in a way that is not verifiably real. The “Cahiers” help establish the difference between the verifiably real and that which seems most true about herself to the author in later life when she fictionalizes her own coming of age. The first “Cahier” holds the key to understanding the exigencies that led to the invention of the character of the Chinese lover, as it reminds us that there is no moment before legend and story-telling, and that individual memory is always constructed imaginatively.

  10. Latvia needs a renewable energy plan / Raquel Dura Lahoz

    Index Scriptorium Estoniae

    Dura Lahoz, Raquel

    2010-01-01

    Läti Transatlantiline Organisatsioon ja Sorose fond korraldasid 21. septembril diskussiooni, mille teemadeks olid taastuv energia ja suurem energiasõltumatus. Diskussioonist võtsid osa poliitikud, investorid, energeetikaeksperdid ja parteide esindajad

  11. Latvia needs a renewable energy plan / Raquel Dura Lahoz

    Index Scriptorium Estoniae

    Dura Lahoz, Raquel

    2010-01-01

    Läti Transatlantiline Organisatsioon ja Sorose fond korraldasid 21. septembril diskussiooni, mille teemadeks olid taastuv energia ja suurem energiasõltumatus. Diskussioonist võtsid osa poliitikud, investorid, energeetikaeksperdid ja parteide esindajad

  12. Influência do posicionamento de membros superiores sobre os efeitos do treinamento muscular inspiratório de curta duração e alta intensidade em indivíduos jovens sadios Influence of arm positioning on the effects of a short-term high intensity inspiratory muscle training protocol in healthy young subjects

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    Vinícius Cavalheri

    2008-12-01

    Full Text Available O objetivo do estudo foi analisar os efeitos de um treinamento muscular inspiratório (TMI de curta duração e alta intensidade, com e sem o apoio de membros superiores, sobre as pressões respiratórias máximas em jovens saudáveis. Trinta jovens do sexo feminino foram aleatoriamente distribuídas em três grupos: o grupo controle (GC fez treinamento placebo na posição sentada; o grupo GSA treinou em pé sem apoio de membros superiores; e o grupo GCA treinou com apoio de membros superiores. O TMI consistiu em três sessões diárias de 10 minutos em três dias consecutivos. Antes, ao final e após um mês do final do treino foram avaliadas a pressão inspiratória máxima (PImáx e a pressão expiratória máxima (PEmáx. No GSA, houve aumento significante da PImáx após o treino de -75±10 para -97±14 cmH2O (pThe purpose of the study was to analyse the effects of a short-term, high-intensity inspiratory muscle training (IMT on healthy youth maximal respiratory pressures, with and without arm bracing postures. Thirty young women were randomly assigned to three groups: control group (CG; group training with no arm bracing (NAB; and group training with arm bracing (AB. The IMT consisted of three 10-minute daily supervised sessions for three consecutive days. Before, at the end, and one month after the end of training, subjects' maximal inspiratory pressures (MIP and maximal expiratory pressures (MEP were assessed. In NAB group a significant increase in MIP was found, from -75±10 to -97±14 cmH2O (p0.05. As to MEP, only in AB group a significant increase on final MEP was found, from 99±16 to 112±16 cmH2O, p<0.05, followed by a decrease one month later (101±19 cmH2O, p<0.05. Hence in young healthy women a short-term, high-intensity IMT protocol increases inspiratory muscle strength independently of arm positioning, simultaneous to an increase in expiratory muscle strength when the IMT is performed with arm bracing.

  13. Incidência e duração da amamentação conforme o tipo de parto: estudo longitudinal no Sul do Brasil Incidence and duration of breast-feeding by pattern of delivery: a longitudinal study in Southeastern Brazil

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    Elisabete Weiderpass

    1998-06-01

    Full Text Available OBJETIVO: Comparar a incidência de amamentação conforme o tipo de parto. MATERIAL E MÉTODO: Estudo de coorte prospectivo de base populacional com 655 crianças brasileiras nascidas no ano de 1993 e acompanhadas durante o primeiro trimestre de vida, através de duas visitas domiciliares. RESULTADOS: A duração da amamentação foi similar entre os nascidos por parto vaginal e cesariana emergencial. Os nascidos por cesariana eletiva apresentaram um risco três vezes maior de interromper a lactação no primeiro mês de vida, após controle de fatores de confusão (razão de odds=3,09; 95% IC 1,3-7,2. Este aumento de risco não persitiu até o terceiro mês de vida. CONCLUSÕES: Recomenda-se aos serviços de saúde atenção especial a lactantes submetidas a cesarianas eletivas, para que seja promovido o aleitamento desde as primeiras semanas, evitando a interrupção precoce.OBJECTIVE: To compare the incidence of breastfeeding according to type of delivery. METHODOLOGY: Population-based cohort study of 655 children born in 1993 and followed up during the first three months of life through home visits. RESULTS: Breastfeeding duration was similar among babies born either by vaginal delivery or by emergency cesarean section. Babies born by elective cesarean section, however, presented a three times higher risk of stopping brestfeeding in the first month of life, after adjusting for possible confounding factors (odds ratio=3.09; 95% CI 1.3-7.2. The increased risk did not persist into the third month of life. CONCLUSIONS: It is recommended that health services pay special attention, in the promotion of breastfeeding, to babies born by elective cesarean section, as a way to avoid early weaning.

  14. Seqüência do tratamento de curta duração da tuberculose pulmonar em Unidades Sanitárias do Vale do Paraíba, 1980-1981, São Paulo, Brasil Evaluation of short-term chemotherapy for pulmonary tuberculosis in the Health Institutions of the Vale do Paraíba, 1980-1981, S. Paulo, Brazil

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    Marília Belluomini

    1984-12-01

    Full Text Available Estuda-se a seqüência do tratamento de curta duração em doentes com tuberculose pulmonar, inscritos e com alta no período de outubro de 1980 a outubro de 1981, nas Unidades Sanitárias do Departamento Regional de Saúde do Vale do Paraíba - DRS-3 - da Secretaria da Saúde do Estado de São Paulo, Brasil. Os dados obtidos pela verificação dos prontuários dos doentes foram analisados sob os seguintes aspectos: distrito sanitário, idade e sexo do paciente, tipo de alta, esquema de tratamento, hospitalização, intolerância medicamentosa e tempo de negativação do escarro. Dos 308 doentes que constituíram a população de estudo, 254 (82,5% tiveram alta por cura, 21 (6,8% por abandono e 33 (10,7% por mudança de diagnóstico, óbito ou transferência. Os resultados confirmam a efetividade do tratamento encurtado da tuberculose pulmonar com os esquemas recomendados, apresentando na área trabalhada baixas taxas de abandono e de hospitalização e resultados bastante favoráveis quanto à negativação dos bacilíferos.The results of the short-term chemotherapy for pulmonary tuberculosis performed on patients who were admitted to the Health Clinics of one of the S. Paulo State's Health Divisions and who completed the treatment during the period from October 1980 to October 1981 are shown. Such aspects of the records as Health Districts, patient's age and sex, success and regimen of treatment, hospitalization, drug toxicity and smear negativity period were analysed. The findings confirm the effectiveness of short-term chemotherapy under program conditions as corroborated by its acceptability to the patients, the success achieved and the benefits in the decrease of the number of admissions to hospital and in the reduction of the sources of infection within a shorter period.

  15. Seleção para duração do ciclo vegetativo em batata e relação com a produtividade de tubérculos Selection for vegetative growth period and its relationship to tuber yield of potato

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    Gabriel B Rodrigues

    2009-09-01

    Full Text Available As cultivares de batata no Brasil geralmente apresentam ciclo vegetativo de 90 a 110 dias, sendo bem mais longo em países de clima temperado, podendo chegar até 150 dias. O ciclo vegetativo longo nestes países proporciona maior produtividade e constitui-se em alternativa para aumento da produção de tubérculos sob condições tropicais. Os objetivos deste trabalho foram avaliar o potencial da seleção para aumentar ou diminuir o ciclo vegetativo da batata e verificar a relação entre a duração do ciclo vegetativo e a produção de tubérculos em condições tropicais. Na primeira geração clonal foram avaliados a produção de tubérculos e o ciclo vegetativo de 1.561 genótipos oriundos de 22 famílias clonais. Na segunda geração clonal foram avaliadas as mesmas características em 320 genótipos selecionados para ciclo vegetativo precoce, intermediário e tardio. A seleção nas gerações iniciais foi eficiente, tanto para diminuir permitiu obter maior ganho do que a seleção entre famílias. Os genótipos mais tardios foram mais produtivos que os mais precoces.Potato cultivars in Brazil generally present a growth cycle duration ranging from 90 to 110 days, whereas in countries located in temperate climate it can reach up to 150 days. Longer vegetative growth cycle in these countries confer higher tuber yield and, in tropical countries it also could be an alternative to increase tuber yield. In this work we evaluated the selection potential for longer or shorter growth cycle duration of potato clones and we determined the relationship between growth cycle duration and tuber yield. In the first clonal generation tuber yield and growth cycle duration were evaluated on 1561 genotypes derived from 22 clonal families. In the second clonal generation, the same traits were evaluated on 320 genotypes selected for earliness, intermediate and late vegetative cycle. Selection in the initial generations was efficient both to decrease and to

  16. Duração do ciclo de vida de Cornops aquaticum (Bruner, 1906 (Orthoptera: Acrididae: Leptysminae e aspectos de seu comportamento alimentar na Amazônia central Life cycle of Cornops aquaticum (Bruner, 1906 (Orthoptera: Acrididae: Leptysminae and aspects of its food behavior at Central Amazonia

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    Maria de Fátima Vieira

    2003-12-01

    Full Text Available O gafanhoto Cornops aquaticum (Bruner, 1906 (Orthoptera: Acrididae: Leptysminae completa seu ciclo de vida em Eichhornia (Pontederiaceae. Em experimentos ao ar livre, durante o período da enchente, foi verificado que a cópula pode durar entre 40 a 120 minutos. Cada postura tem em média 13,4 ovos (+/- 3,2 e o período de incubação durou 34,1 dias (+/- 1,97. A duração média do desenvolvimento de ovo a adulto foi de 156,2 dias, sendo 34,1 do estágio de ovo, 53,4 do estágio ninfal e 68,7 do estágio adulto. Alimentou-se de 6 espécies de macrófitas aquáticas dentre as 13 oferecidas. Ninfas (N e Adultos (A sobreviveram mais dias em Pistia stratiotes (N = 43 % até 30 dias e A =1 % até 27 dias e Pontederia sp. (N = 85 % e A = 40 % até 24 dias que em Limnobium sp. (N =13% e A =10 % até 12 dias, Ludwigia sp. (N =3 % até 24 dias e A =15 % até 9 dias, Azolla sp. (N =35 % até 9 dias e A =15 % até 12 dias e Paspalum repens (N =3 % até 21 dias e A =5 % até 24 dias.Life cycle of the grasshopper Cornops aquaticum (Bruner, 1906 (Orthoptera: Acrididae: Leptysminae is dependent on Eichhornia (Pontederiaceae. Experiments were carried outdoors during receding water, the Mating last for about 40 and 120 minutes. The ootheca has an average of 13.4 (+/- 3.2 eggs. Incubation lasted for 34.1 days (+/- 1.97. Mean durations of total development from egg to adult was 156.2 days, being 34.1 in the egg stage, 53.4 in the ninphal stage, and 68.7 in the adult stage. Nymphs (N and adults (A accepted only six aquatic macrophytes out of 13 species offered during 30 days; survived more time in Pistia stratiotes (N = 43 %, 30 days and A = 1 %, 27 days and Pontederia sp. (N = 85 % and A = 40 % until 24 days than Limnobium sp. (N =13% and A =10 % until 12 dias, Ludwigia sp. (N =3 %, 24 days and A =15 %, 9 days Azolla sp. (N =35 %, 9 days and A =15 %, 12 days and Paspalum repens (N =3 %, 21 days and A =5 %, 24 days.

  17. Effect of polylactic acid glue in preventing epidural scar adhesion after laminectomy in rabbits

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    LIU Li-min; SONG Yue-ming; DUAN Hong; DING Yong-li; LU Bing

    2006-01-01

    Objective: To determine the efficacy of polylactic acid glue in preventing epidural scar adhesion after laminectomy in rabbits.Methods: Twenty-four apanese white rabbits underwent laminectomy (including the attached ligaments)at L2 and Ls. After laminectomy at L5, polylactic acid glue was sprayed on the dura and nerve roots and this segment was taken as the experimental group. After laminectomy at L2 , nothing was used and this segment was enrolled as the self control group. Four rabbits were killed every two weeks postoperatively till the end of the experiment at 12weeks. Then the operated spine was observed grossly,histologically and ultrastructurally to check the degree of scar formation, the status of epidural scar adhesion, the absorption of the glue, and the intracellular structure of fibroblasts.Results: The glue coagulated immediately after spraying and showed excellent hemostatic effect. The glue membrane was easy to be taken away from the dura mater of the samples for 2 weeks and there were no cells in the epidural space in the experimental group. But the dura mater was covered by hematoma in the control group,which formed mild adhesion, with fibroblasts proliferating actively. In the 4th week, some glue shivers remained in the epidural space with fibroblasts increasing a little, and the dura mater was smooth in the experimental group.However, in the control group, the formed scar was fragile and conglutinated with the dura mater diffusely and fibroblasts were much more than those in the experimental group. In the 6th-12th weeks, there was a potential interspace between the scar and the dura mater, and the polylactic acid glue was absorbed completely in the experimental group. Much tough scar was found in the control group, which was very difficult to dissect from the dura mater and the surrounding tissues. From the ultrastructural observation of the fibroblasts, the nucleus became much bigger and the rough endoplasmic reticulum was much more plentiful in

  18. Intensidade e duração dos esforços físicos em aulas de Educação Física Intensidad y duración de los esfuerzos físicos en clases de Educación Física Intensity and duration of physical efforts in Physical Education classes

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    Marina Marques Kremer

    2012-04-01

    Full Text Available OBJETIVO: Avaliar a intensidade e a duração dos esforços físicos em aulas de Educação Física no ensino fundamental e médio. MÉTODOS: Estudo transversal de base escolar por meio de observação de 218 aulas de Educação Física, incluindo um total de 272 estudantes (avaliados três vezes cada um. O estudo foi realizado em Pelotas, RS, de agosto a setembro de 2009. Para a intensidade dos esforços, foram utilizados acelerômetros e adotados os pontos de corte (em counts por minuto: atividades sedentárias (0 a 100, leves (101 a 2.000, moderadas (2.001 a 4.999, vigorosas (5.000 a 7.999 e muito vigorosas (> 8.000. RESULTADOS: O tempo médio de duração das aulas foi de 35,6 minutos (dp 6,0. A proporção média de tempo das aulas em atividades físicas de intensidade moderada a vigorosa foi de 32,7% (dp 25,2. Os meninos (44,1% envolveram-se significativamente mais em atividades físicas moderadas a vigorosas do que as meninas (21,0%; p OBJETIVO: Evaluar la intensidad y la duración de los esfuerzos físicos en clases de Educación Física en la enseñanza básica y media. MÉTODOS: Estudio transversal de base escolar por medio de observación de 218 clases de Educación Física, incluyendo un total de 272 estudiantes (evaluados tres veces cada uno. El estudio fue realizado en Pelotas, Sur de Brasil, de agosto a septiembre del año 2009. Para la intensidad de los esfuerzos, se utilizaron acelerómetros y se adoptaron los puntos de corte (en counts por minuto: actividades sedentarias (0 a 100, leves (101 a 2.000, moderadas (2.001 a 4.999, vigorosas (5.000 a 7.999 y muy vigorosas (> 8.000. RESULTADOS: El tiempo promedio de duración de las clases fue de 35,6 minutos (de 6,0. La proporción promedio de tiempo de las clases en actividades físicas de intensidad moderada a vigorosa fue de 32,7% (desviación estándar 25,2. Los niños varones (44,1% se involucraron significativamente en actividades físicas moderadas a vigorosas con relación a

  19. Estudo preliminar das relações entre duração da parada cardiorrespiratória e suas consequências nas vítimas de trauma Preliminary study of the relationship between the cardiopulmonary arrest time and its consequences in patients who underwent trauma

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    Andréia Bertelli

    1999-06-01

    Full Text Available Foi proposta desta pesquisa obter subsídios para iniciar ou manter manobras de reanimação cardiopulmonar (RCP especificamente em vítimas de trauma. A duração da parada e reanimação cardiopulmonar de sobreviventes foi descrita, assim como, o desempenho cerebral e mortalidade dessas vítimas 24, 48 e 72 horas após tais eventos terem ocorrido. Com os resultados dessa caracterização estudou-se a relação entre tempo de parada e reanimação cardiorrespiratória, e, mortalidade. Os dados foram obtidos em plantões no Pronto Socorro do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Grande parte das vítimas (93,4% apresentaram trauma grave e a principal "causa mortis" foi trauma crânio-encefálico. A sobrevivência ao período de 72 horas foi de 10%. A avaliação de 72 horas, das vítimas sobreviventes a parada cardiorrespiratória (PCR de causa traumática mostrou mau desempenho cerebral dessas vítimas no período. A sobrevida após o primeiro episódio de PCR relacionou-se mais consistentemente com o tempo de PCR das vítimas de trauma do que o tempo de RCP. O tempo de PCR The proposal of this research was to obtain parameters to start or maintain cardiopulmonary resuscitation (CPR in victims of trauma. The duration of the cardiac arrest and the CPR of the survivors was described, as well as the cerebral performance and the mortality of these victims 24, 48 and 72 hours after these events had happened. With the results of this caracterization the relation between duration of cardiac arrest time, CPR and mortality were described. Data for this report were coleted in Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo emergency departament. A big amount of the victims (93, 4% presents severe trauma and main cause of death was brain injury. Survival at 72 hours after CPR was 10%. The assessment, during the 72 hour period, of the survivors from cardiac arrest of traumatic cause has

  20. A percepção das mães sobre o apoio paterno: influência na duração do aleitamento materno La percepción de las madres sobre el apoyo paterno: influencia en la duración de la lactancia materna The maternal perception on paternal support: influence on the duration of breastfeeding

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    Priscila Palma da Silva

    2012-09-01

    Full Text Available OBJETIVO: Estudo de coorte prospectiva dos bebês nascidos na cidade de Pelotas entre setembro de 2002 e maio de 2003, com o objetivo de avaliar a percepção das mães quanto ao apoio paterno e sua influência na duração do aleitamento materno (AM. MÉTODOS: A população inicial do estudo foi de 2.741 bebês, sendo que uma amostra aleatória de 30% destes foi acompanhada no 1º, 3º e 6º meses, baseada em cálculo amostral com um nível de significância de 95% e poder estatístico de 80% para detectar risco relativo de 2,0. Foram realizadas análises univariada e multivariada, sendo que somente as variáveis com pOBJETIVO: Estudio de cohorte prospectivo de los bebés nacidos en la ciudad de Pelotas (Rio Grande do Sul, Brasil, entre septiembre de 2002 y mayo de 2003, con el objetivo de evaluar la percepción de las madres respecto al apoyo paterno y su influencia en la duración de la lactancia materna (LM. MÉTODOS: La población inicial del estudio fue de 2.741 bebés, siendo acompañada en el primero, tercero y sexto meses una muestra aleatoria y representativa de 30% de éstos, basada en cálculo muestral, con un nivel de significancia de 95% y poder estadístico de 80%, para detectar riesgo relativo de 2,0. Se realizaron análisis uni y multivariados, siendo que solamente las variables con pOBJECTIVE: A cohort prospective study of newborns in the city of Pelotas, Southern Brazil, between September 2002 and May 2003, which aims at evaluating the perception of mothers as to fatherly support and its influence in breastfeeding duration. METHODS: The initial population included 2,741 babies, and a random and representative sample of 30% was followed-up on the first, third, and sixth months, with a significance level of 95% and statistical power of 80% to detect a relative risk of 2.0. Univariate and multivariate analyses were applied. Variables with p<0.05 were considered as significantly associated with the outcome. RESULTS: In the first

  1. Influência de um programa de atividade física de longa duração sobre a força muscular manual e a flexibilidade corporal de mulheres idosas Influence of a long-term physical activity program on hand muscle strength and body flexibility among elderly women

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    JR Rebelatto

    2006-01-01

    Full Text Available Objetivo: O presente trabalho examinou a influência de um programa de exercícios físicos prolongados (dois anos sobre a força muscular e a flexibilidade corporal de mulheres idosas (60-80 anos, não institucionalizadas, da Província de Salamanca (Espanha. Método: Participaram 32 sujeitos, escolhidos dentre os participantes do Programa de Revitalização Geriátrica desenvolvido pela Universidade de Salamanca. Os critérios para escolha dos sujeitos foram: serem do sexo feminino, terem entre 60 e 80 anos e terem participado de pelo menos 74% do programa de atividades físicas. Foram realizadas 174 sessões de atividade física, durante 58 semanas, com freqüência de três vezes por semana e duração de 50 a 55 minutos cada uma. No período do experimento foram realizadas quatro medidas da força muscular manual, por meio de manômetro de pressão, e da flexibilidade corporal, por meio do teste sit and reach. Os dados foram analisados por meio de ANOVA com medidas repetidas. Resultados: Tanto em relação à força muscular, quanto à flexibilidade os dados apontam para a ausência de diferenças significativas (p= 0,005. Conclusões: O programa contribuiu para a manutenção da força de preensão manual no período de dois anos e, em relação à flexibilidade corporal, os dados indicam a necessidade de reprogramação dos exercícios destinados ao desenvolvimento de tal capacidade.Objective: The present study evaluated the influence of a two-year physical activity program on muscle strength and body flexibility among non-institutionalized elderly women (60-80 years old, from Salamanca Province in Spain. Method: Thirty-two individuals were chosen to take part in the Geriatric Revitalization Program at Salamanca University. The selection criteria were that they should be female, between 60 and 80 years old, with an attendance rate of at least 74% in the physical activity program. There were 174 physical activity sessions, over a 58-week

  2. O efeito da deambulação na duração da faze ativa do trabalho de parto El efecto de la deambulación en la duración de la fase activa del trabajo de parto The ambulation effect in the active stage duration of the labor

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    Fabiana Villela Mamede

    2007-09-01

    Full Text Available O trabalho teve como objetivo analisar a associação entre a deambulação e a duração da fase ativa do trabalho de parto. Metodologia: estudo analítico de intervenção do tipo quase experimental. Fizeram parte do estudo 80 parturientes primíparas, admitidas em trabalho de parto espontâneo, no início da fase ativa. Instrumentos de coleta de dados: podômetro para medir a distância percorrida em metros, Escala Visual Numérica (EVN de dor, formulário para o registro de dados. Resultados: as participantes percorreram uma distância média de 1.624 metros, 63,09% da fase ativa do trabalho de parto e em um tempo médio de 5 horas. Verificou-se que a quantidade deambulada durante as três primeiras horas da fase ativa está associada a um encurtamento do trabalho de parto, sendo que a cada 100 metros percorridos ocorreu uma diminuição de 22 minutos na primeira hora, 10 minutos na segunda hora e 6 minutos na terceira hora.La finalidad de este trabajo fue la de analizar la asociación entre la deambulación y el tiempo de la fase activa del trabajo de parto. Metodología: estudio analítico de intervención del tipo casi experimental. Participaron del estudio 80 parturientes primíparas, admitidas en trabajo de parto espontáneo, en el inicio de la fase activa. Instrumentos de recopilación de datos: podómetro para medir la distancia transcurrida en metros, Escala visual numérica de dolor, Formulario para el registro de datos. Resultados: las participantes transcurrieron una distancia media de 1624metros, 63,09% de la fase activa del trabajo de parto y en un tiempo promedio de 5 horas. Se verificó que la cantidad deambulada durante las tres primeras horas de la fase activa está asociada a un acortamiento del trabajo de parto. Para cada 100 metros transcurridos ocurrió una disminución de 22 minutos en la primera hora, 10 minutos en la segunda hora y 6 minutos en la tercera hora.This study aimed to analyze the association between

  3. Efeito do treinamento físico de membros superiores aeróbio de curta duração no deficiente físico com hipertensão leve The effect of short term Aerobic physical training using upper limbs in paraplegic persons with mild to moderate hypertension

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    Sandra Haddad

    1997-09-01

    Full Text Available OBJETIVO: Verificar as alterações provocadas pelo treinamento físico (TF, com membros superiores (MMSS, em condição aeróbia de curta duração, sobre variáveis dos sistemas cardiovascular e metabólico. MÉTODOS: Foram estudados 11 deficientes físicos (DF paraplégicos, com média de idade de 59 anos, sendo 7 homens e 4 mulheres, com lesão de T9 a T11 e grau leve de hipertensão arterial sistêmica (HAS. Os DF foram avaliados antes e após 12 semanas de um programa de TF supervisionado de MMSS, por meio de teste ergométrico (TE em cicloergômetro mecânico adaptado para MMSS, utilizando-se protocolo intermitente com incremento de carga de 125kgm/min (20w para mulheres e 140kgm/min (25w para homens a cada 3min., em velocidade que variou de 83 a 95rpm. O consumo de oxigênio (VO2 foi calculado de acordo com a equação para MMSS do American College of Sports Medicine. A intensidade do exercício durante o programa de TF foi estabelecida pela reserva de freqüência cardíaca (RFC de Karvonen, com variação de 65% a 85% e escala de percepção subjetiva ao esforço de Borg obtida pelo TE. RESULTADOS: A capacidade aeróbia máxima estimada aumentou 22% (930±349 vs 1138±290mL/min; p=0,003; a pressão arterial sistólica (PAS e diastólica (PAD em repouso e no exercício submáximo diminuíram em 4%, 15% e 5%, 5%, respectivamente. CONCLUSÃO: O TF aeróbio de intensidade leve a moderada com MMSS, além de melhorar a aptidão funcional exerce também papel importante como modelo terapêutico não medicamentoso na resposta hipertensiva observada em DF paraplégicos.PURPOSE: To study the modifications induced by physical training (PT using upper limbs in aerobic condition of short duration on cardiovascular and metabolic variables. METHODS: Eleven paraplegic persons, with a mean age of 59 years, 7 men and 4 women with lesions at T9 through T11 and mild hypertension (HAS were studied. The patients were studied before and after 12 weeks of a

  4. Impact of direct seeding mulch-based cropping systems on soil nematodes in a long-term experiment in Madagascar Impacto do plantio direto com cobertura vegetal nos nematódeos edáficos em experimento de longa duração em Madagascar

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    Cécile Villenave

    2009-08-01

    Full Text Available The objective of this work was to assess the effects of conventional tillage and of different direct seeding mulch-based cropping systems (DMC on soil nematofauna characteristics. The long-term field experiment was carried out in the highlands of Madagascar on an andic Dystrustept soil. Soil samples were taken once a year during three successive years (14 to 16 years after installation of the treatments from a 0-5-cm soil layer of a conventional tillage system and of three kinds of DMC: direct seeding on mulch from rotation soybean-maize residues; direct seeding of maize-maize rotation on living mulch of silverleaf (Desmodium uncinatum; direct seeding of bean (Phaseolus vulgaris-soybean rotation on living mulch of kikuyu grass (Pennisetum clandestinum. The samples were compared with samples from natural fallows. The soil nematofauna, characterized by the abundance of different trophic groups and indices (MI, maturity index; EI and SI, enrichment and structure indices, allowed the discrimination of the different cropping systems. The different DMC treatments had a more complex soil food web than the tillage treatment: SI and MI were significantly greater in DMC systems. Moreover, DMC with dead mulch had a lower density of free-living nematodes than DMC with living mulch, which suggested a lower microbial activity.O objetivo deste trabalho foi avaliar os efeitos do plantio convencional e de diferentes sistemas de plantio direto com cobertura vegetal (DMC nas características da nematofauna edáfica. Foi intalado um experimento de longa duração nos platôs centrais de Madagascar em um Inceptisol ândico. O solo foi amostrado uma vez por ano durante três anos consecutivos (14 a 16 anos após a instalação dos tratamentos na camada de 0-5 cm do solo em plantio convencional e em três tipos de DMC: plantio direto sobre cobertura morta de resíduos da rotação soja-milho; plantio direto da sucessão milho-milho sobre cobertura viva de Desmodium

  5. Estimating leaf wetness duration over turfgrass, and in a 'Niagara Rosada' vineyard, in a subtropical environment Estimativa da duração do período de molhamento sobre o gramado e em vinhedo de 'Niagara Rosada' em condição subtropical

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    Jorge Lulu

    2008-12-01

    Full Text Available Leaf wetness duration (LWD is a key parameter in agrometeorology because it is related to plant disease occurrence. As LWD is seldomly measured in a standard weather station it must be estimated to run warning systems for schedule chemical disease control. The objective of the present study was to estimate LWD over turfgrass considering different models with data from a standard weather station, and to evaluate the correlation between estimated LWD over turfgrass and LWD measured in a 'Niagara Rosada' vineyard, cultivated in a hedgerow training system, in Jundiaí, São Paulo State, Brazil. The wetness sensors inside the vineyard were located at the top of the plants, deployed at an inclination angle of 45º and oriented southwest, with three replications. The methods used to estimate LWD were: number of hours with relative humidity above 90% (NHRH > 90%, dew point depression (DPD, classification and regression tree (CART and Penman-Monteith (PM. The CART model had the best performance to estimate LWD over turfgrass, with a good precision (R² = 0.82 and a high accuracy (d = 0.94, resulting in a good confidence index (c = 0.85. The results from this model also presented a good correlation with measured LWD inside the vineyard, with a good precision (R² = 0.87 and a high accuracy (d = 0.96, resulting in a high confidence index (c = 0.93, showing that LWD in a 'Niagara Rosada' vineyard can be estimated with data from a standard weather station.A duração do período de molhamento (DPM é uma variável agrometeorológica chave para a ocorrência de doenças de plantas. Como a DPM é raramente medida nas estações meteorológicas, ela deve ser estimada quando se pretende empregar sistemas de alerta de controle químico. Desse modo, o objetivo do presente estudo foi avaliar a estimativa da DPM sobre gramado por diferentes modelos a partir de dados meteorológicos obtidos em uma estação meteorológica padrão e verificar as relações entre a DPM

  6. O tratamento da Classe III: revisão sistemática - Parte I. Magnitude, direção e duração das forças na protração maxilar The treatment of Class III: systematic review - Part I. Magnitude, direction and duration of the forces in the maxillary protraction

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    Anna Paula Rocha Perrone

    2009-10-01

    Full Text Available INTRODUÇÃO: para o tratamento da Classe III durante o crescimento, a protração maxilar é a terapia mais relatada na literatura. Durante o tratamento, é requerida especial atenção à mecânica utilizada para a correção do problema. OBJETIVO: sintetizar as informações relativas à magnitude, direção e tempo diário da aplicação das forças, por meio de uma revisão sistemática. MÉTODOS: estudos foram identificados a partir de uma pesquisa eletrônica no Medline database - Entrez PubMed (178 artigos e Bireme (550 artigos, no período de janeiro de 1983 a dezembro de 2008. Após um criterioso processo de inclusão e exclusão, 56 estudos primários foram selecionados e submetidos a um segundo processo de seleção, restando 39 artigos. Foram calculados a média e o desvio-padrão, bem como os valores mínimos e máximos para a magnitude, a direção e a quantidade de horas de uso das forças de protração maxilar. RESULTADOS E CONCLUSÃO: as médias de magnitude, direção e duração das forças de protração maxilar foram de, respectivamente, 447,8 gramas, 27,5 graus de inclinação em relação ao Plano Oclusal, e 15,2 horas por dia.INTRODUCTION: For the treatment of Class III during growth, maxillary protraction therapy is the most reported in the literature. During the treatment is required special attention to the mechanics used to fix the problem. AIM: To synthesize informations about the magnitude, direction and time of daily application of forces, through a systematic review. METHODS: Studies were identified from an electronic search on Medline database - Entrez PubMed (178 articles and Bireme (550 articles, from January 1983 until December 2008. After rigorous process of inclusion and exclusion 56 primary studies were selected and subjected to a second selection process, remaining 39 articles. It was calculated the average and standard deviation, and the minimum and maximum values for magnitude, direction and usage

  7. Performance of cylindrical leaf wetness duration sensors in a tropical climate condition Desempenho de sensores cilíndricos para medida da duração do período de molhamento foliar em condições de clima tropical

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    Eduardo Alvarez Santos

    2008-12-01

    conditions, where LWD measured by cylinders were two hours longer than by flat plate sensors.Medidas da duração do período de molhamento (DPM são necessárias para diversos sistemas de alerta fitossanitário, uma vez que a DPM é uma variável importante para a epidemiologia. O sensor cilíndrico é um sensor eletrônico barato e que pode ser facilmente produzido. Esse sensor foi inicialmente projetado para medir DPM em cebola, contudo alguns estudos indicam que ele também pode ser utilizado em estações meteorológicas e outras culturas. Portanto, o objetivo deste estudo foi avaliar o desempenho de sensores cilíndricos sob condições tropicais, no Brasil, tendo-se as medidas obtidas pelo sensor de placa como referência. Antes de serem instalados no campo, todos os sensors eletrônicos utilizados no estudo (placa e cilíndricos foram pintados com tinta latex branca e, em seguida, submetidos a tratamento térmico. Testes de laboratório foram realizados para determinar um limiar de resistência, a partir do qual os sensores seriam considerados molhados, e o tempo de reposta dos sensores ao molhamento. No campo, todos os sensores foram inicialmente instalados na horizontal a 30 cm de altura sobre gramado, visando a avaliar a variabilidade entre os sensores de DPM. A variabilidade entre os sensores cilíndricos na horizontal foi reduzida com a adoção de um limiar de resistência específico para cada sensor. O coeficiente médio de variação para DPM diária medida pelos sensores cilíndricos foi igual a 9,7%. Posteriormente, os sensores cilíndricos foram instalados em 5 ângulos diferentes com a horizontal: 0, 15, 30, 45, and 60º. As medidas obtidas por esses sensores são comparáveis com a medida padrão, fornecida por sensores de placa instalados a 45º e mesma altura. A mudança do ângulo de instação não teve efeito sistemático sobre as medidas da DPM para as condições locais, uma vez que as correlações entre as medidas dos sensores de placa e

  8. Ruminal degradability of hard or soft texture corn grain at three maturity stages Degradabilidade ruminal de grãos de milho de textura dura ou macia em três estádios de maturação

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    Marcos Neves Pereira

    2004-01-01

    Full Text Available The predominance of vitreous endosperm in hard texture flint corn (Zea mays L. can decrease ruminal starch digestion comparatively to the farinaceous endosperm of dent corn, reducing energy content of the grain. The objective of this experiment was to evaluate the effects of texture and maturity stage on ruminal degradability of corn grain. Two dent and two flint hybrids were harvested at the early dent, half milk line, and black layer stages. The proportion of vitreous endosperm (vitreousness in dent hybrids was 44.3%, while in flint it was 67.0%. There was a linear increase in vitreousness with advancing maturity. Flint hybrids at the early dent stage were more vitreous than dent at the black layer stage. The increase in vitreousness per maturation day was greater for flint hybrids. Grains were incubated in situ in the rumen of 6 cows. The 24-hour ruminal dry matter degradation was 63.3% for dent corn and 52.4% for flint corn. The 72-hour incubation residues of dent and flint hybrids were 7.6% and 15.6%, respectively. Ruminal degradability was similar between hybrids at the early dent and half milk line stages. There was a marked texture effect on ruminal degradability at the black layer stage (quadratic effect of maturity stage and interaction between texture and maturity stage. Use of dent hybrids, compared to flint hybrids, may result in smaller relative reduction in ruminal starch digestion in situations of late grain harvesting.A predominância de endosperma vítreo em milho (Zea mays L. flint de textura dura pode deprimir a digestão ruminal do amido comparativamente ao endosperma farináceo de milho dentado, reduzindo o conteúdo energético do grão. O objetivo deste experimento foi avaliar os efeitos da textura e do estádio de maturidade sobre a degradabilidade ruminal de grãos de milho. Dois híbridos dentados e dois duros foram colhidos nos estádios dentado inicial, metade da linha do leite e linha preta. A proporção de

  9. Mineralização de azoto de diferentes resíduos orgânicos em incubação laboratorial de longa duração Nitrogen mineralization from different organic residues in long-term laboratory incubation

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    J.P. Carneiro

    2007-07-01

    Full Text Available O objectivo do presente trabalho foi determinar, em condições laboratoriais e através de um ensaio de incubação de longa duração (443 dias, a mineralização do N orgânico resultante da incorporação de lamas de depuração, compostado de resíduos sólidos urbanos (RSU, chorume de bovinos e lamas celulósicas, num Solo Litólico de granito. À excepção das lamas celulósicas (80 kg N ha-1, os resíduos orgânicos foram incorporados em duas doses (80 e 160 kg N ha-1. A avaliação da mineralização do N orgânico dos resíduos foi efectuada através da medição do teor de N mineral acumulado ( N-NH4+ e N-NO3 no solo com resíduo, tendo as amostragens sido efectuadas aos 1, 2, 3, 4, 8, 11, 15, 22, 29, 36, 46, 59, 74, 88, 120, 144, 186, 249, 338 e 443 dias após o início da incubação. O chorume e as lamas de depuração foram os correctivos orgânicos que promoveram teores iniciais de N mineral no solo mais elevados, tendo o chorume disponibilizado no final do ensaio, na média das duas doses, 50% do N total incorporado, e as lamas 76%. As lamas celulósicas e o compostado de RSU originaram imobilização de azoto, tendo-se observado esse efeito durante todo o ensaio e por um período de 4-5 meses, respectivamente. Em relação ao N total aplicado, e após 443 di-as de incubação, o tratamento com lamas apresentou uma imobilização de 43%, enquanto que no tratamento com compostado de RSU a mineralização foi de 26%. Os resíduos orgânicos utilizados apresentaram um comportamento muito distinto no que respeita à disponibilização de azoto após a sua incorporação ao solo. Face a essa diferença, a aplicação de chorume e das lamas de depuração deverá ser acompanhada na prática pela redução das adubações azotadas imediatas, enquanto que na utilização de compostado de RSU e, sobretudo de lamas celulósicas, poderse-á impor um reforço da adubação azotada de fundo e de cobertura.The aim of this study was to

  10. Fatores associados à duração dos benefícios por incapacidade: um estudo de coorte Factores asociados a la duración de los beneficios por incapacidad: un estudio de cohorte Factors associated with duration of disability benefits: a cohort study

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    Norma Suely Souto Souza

    2012-06-01

    Full Text Available OBJETIVO: Analisar fatores associados à duração dos benefícios por incapacidade por doenças musculoesqueléticas na região cervical e/ou em membros superiores relacionadas ao trabalho. MÉTODOS: Estudo de coorte ambispectivo com 563 trabalhadores segurados do Regime Geral da Previdência Social que receberam benefício por incapacidade temporária por doenças musculoesqueléticas da região cervical e membros superiores relacionadas ao trabalho em Salvador, BA, em 2008. Os dados provieram de um inquérito conduzido pela Auditoria Regional do Instituto Nacional do Seguro Social e de registros administrativos. Foram analisadas variáveis sociodemográficas, relacionadas ao trabalho, características do agravo e aspectos relacionados ao seguro social. Os fatores associados ao tempo até a cessação do benefício foram identificados com técnicas de análise de sobrevida. RESULTADOS: Posição socioeconômica baixa (RR = 1,29; IC95% 1,02;1,64, idade abaixo de 39 anos (RR = 1,23; IC95% 1,03;1,47, reposição de renda pelo Instituto Nacional do Seguro Social OBJETIVO: Analizar factores asociados a la duración de los beneficios por incapacidad por enfermedades musculoesqueléticas en la región cervical y/o en miembros superiores relacionadas al trabajo. MÉTODOS: Estudio de cohorte ambispectivo con 563 trabajadores asegurados del Régimen General de la Previdencia Social que recibieron beneficio por incapacidad temporal por enfermedades musculoesqueléticas de la región cervical y miembros superiores relacionadas con el trabajo en Salvador, Northeastern Brazil, en 2008. Los datos resultaron de una pesquisa conducida por la Auditoria Regional del Instituto Nacional del Seguro Social y de registros administrativos. Se analizaron variables sociodemográficas, relacionadas con el trabajo, características del agravio, y aspectos relacionados con el seguro social. Los factores asociados al tiempo hasta la cesantía del beneficio fueron

  11. Qualidade do solo avaliada pelo "Soil Quality Kit Test" em dois experimentos de longa duração no Rio Grande do Sul Soil Quality Evaluated by "Soil Quality Kit" in two long-term soil management experiments in Rio Grande do Sul State, Brazil

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    Telmo Jorge Carneiro Amado

    2007-02-01

    Full Text Available A avaliação da qualidade do solo (QS é importante estratégia no planejamento agrícola, possibilitando a identificação e o aprimoramento de sistemas de manejo com características de alta produtividade e de preservação ambiental. O presente estudo foi realizado em dois experimentos de longa duração (10 e 15 anos conduzidos no Sul do Brasil e teve por objetivo avaliar o efeito de sistemas de manejo na QS, utilizando um kit de análise expedita de qualidade de solo (KQS, desenvolvido pelo Instituto de Qualidade do Solo-USDA-ARS. A eficiência desse kit foi avaliada pela comparação com os métodos tradicionais utilizados na ciência do solo. Nas duas áreas experimentais investigou-se um total de 12 tratamentos, os quais englobaram sistemas de preparo com diferentes intensidades de revolvimento do solo (preparo convencional, preparo reduzido e plantio direto e sistemas de culturas com ampla faixa de adição de resíduos vegetais ao solo, além da aplicação de doses anuais de N-uréia, variando de 0 a 144 kg ha-1. Em cada base experimental uma área sob campo natural foi avaliada, servindo como referência da condição do solo na ausência de interferência antrópica. Como indicadores de QS, foram avaliados infiltração de água, respiração do solo, densidade do solo, teor de nitrato+nitrito (N-NO3- + N-NO2-, estabilidade de agregados em água e pH. De maneira geral, os coeficientes de correlação entre os métodos do KQS e os métodos tradicionais foram elevados, sendo o mais alto para o indicador pH (r = 0,98 e o menor para o indicador infiltração de água no solo (r = 0,42. Os tratamentos selecionados foram teoricamente ordenados em ordem crescente de QS, a qual foi reproduzida de forma eficiente pelo índice de estoque de carbono (IEC, calculado pela razão entre o estoque de C orgânico do solo, na camada de 0-5 cm, de cada tratamento e o estoque de C orgânico no solo sob campo natural. Os indicadores estabilidade de

  12. Effective Response of Methotrexate for Recurrent Idiopathic Hypertrophic Spinal Pachymeningitis

    Science.gov (United States)

    Park, Tae Joon; Seo, Won Deok; Kim, Sang Young; Cho, Jae Hoon; Kim, Dae Hyun

    2016-01-01

    Idiopathic hypertrophic spinal pachymeningitis (IHSP) is a chronic progressive and diffuse inflammatory fibrosis of the spinal dura mater. Though treatment of IHSP is surgical decompression with steroid therapy, treatment for recurrent IHSP is controversial. Our patient was diagnosed with IHSP based on magnetic resonance imaging (MRI) and underwent laminectomy for decompression following steroid pulse therapy. Despite maintenance of steroid therapy, the patient experienced 3 recurrences. As an alternative immunosuppressant medication, methotrexate was introduced with low-dose steroid. Fortunately, the symptom was resolved, and a decrease of dura thickening was revealed on MRI. We present the case and suggest that methotrexate might be an effective treatment modality for recurrent IHSP.

  13. A dexmedetomidina para sedação, por via venosa, não interfere com a duração dos bloqueios sensitivo e motor da raquianestesia La dexmedetomidina para sedación, por vía venosa, no interfiere con la duración del bloqueo sensitivo y motor de la raquianestesia Intravenous dexmedetomidine for sedation does not interfere with sensory and motor block duration during spinal anesthesia

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    Edno Magalhães

    2006-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A anestesia locorregional é uma prática freqüente e de grande aplicabilidade em Anestesiologia. Contudo, o paciente pode tornar-se ansioso, fazendo-se necessária a sedação. Os agentes benzodiazepínicos, opióides e o propofol são amplamente utilizados com este objetivo. Os agonistas alfa2-adrenérgicos possuem propriedades hipnóticas e sedativas e são uma alternativa no arsenal terapêutico, conferindo estabilidade hemodinâmica e mínima depressão respiratória. O objetivo deste estudo foi avaliar a segurança e a interferência do uso da dexmedetomidina ou do midazolam, por via venosa, na duração dos bloqueios motor e sensitivo em raquianestesia. MÉTODO: Foram estudadas 35 pacientes adultas, do sexo feminino, estado físico ASA I e II, submetidas à raquianestesia com bupivacaína a 0,5% hiperbárica (15 mg, para cirurgia ginecológica eletiva, distribuídas de modo aleatório em dois grupos: grupo M (n = 17 - sedação com midazolam em infusão contínua a 0,25 µg.kg-1.min-1 e grupo D (n = 18 - sedação com dexmedetomidina em infusão contínua a 0,5 µg.kg-1.min-1. A velocidade de infusão foi ajustada para manter o valor de BIS entre 60 e 80. Foram analisados os valores de PAS, PAD, FC, SpO2, BIS, extensão e duração dos bloqueios sensitivo motor (escala de Bromage. RESULTADOS: Não houve diferença estatística significativa entre os grupos quanto à idade, peso, nível de bloqueio sensitivo, variação na pressão arterial e freqüência cardíaca e na duração dos bloqueios sensitivo e motor. CONCLUSÕES: A dexmedetomidina utilizada em sedação, por via venosa, não interferiu nos parâmetros hemodinâmicos, duração ou extensão dos bloqueios sensitivo e motor na raquianestesia, representando boa opção para sedação durante anestesia locorregional.JUSTIFICATIVA Y OBJETIVOS: La anestesia regional se practica con frecuencia en anestesiología. No obstante, algunos pacientes pueden mostrar

  14. Remodelagem atrial elétrica reversa após cardioversão de fibrilação atrial isolada de longa duração Remodelación atrial eléctrica reversa tras cardioversión de fibrilación atrial aislada de larga duración Reversal atrial electrical remodeling following cardioversion of long-standing lone atrial fibrillation

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    Eduardo Correa Barbosa

    2009-09-01

    Full Text Available FUNDAMENTO: A fibrilação atrial (FA isolada promove mudanças eletrofisiológicas, chamadas de "remodelamento elétrico", facilitando sua recorrência e manutenção. Há evidência de que o processo de remodelamento seja reversível após a recuperação do ritmo sinusal (RS. Entretanto, o momento para a recuperação das propriedades eletrofisiológicas ainda não foi definido. OBJETIVO: O objetivo desse estudo foi avaliar a ativação elétrica atrial usando o eletrocardiograma de alta resolução de onda P (P-ECGAR pós-cardioversão da FA de longa duração, concentrando-se no processo de remodelamento reverso para identificar o momento da estabilização do processo. MÉTODOS: Indivíduos com FA isolada persistente, candidatos à cardioversão com conversão bem-sucedida ao RS, foram incluídos no estudo. A P-ECGAR foi realizada imediatamente após a reversão ao ritmo sinusal e repetida após 7 e 30 dias. RESULTADOS: Dentre os 31 indivíduos, 9 apresentaram recorrência precoce da FA, todos nos primeiros 7 dias após a cardioversão, e 22 permaneceram em RS por pelo menos um mês; o ECGAR foi obtido no sétimo e no trigésimo dias após a cardioversão. No 30º dia, a duração da onda P progressivamente diminuiu do primeiro para o terceiro ECGAR (duração da onda P: 185,5±41,9 m/s vs 171,7±40,5 m/s vs 156,7±34,9 m/s, respectivamente, 1º, 2º e 3º ECGAR; pFUNDAMENTO: La fibrilación atrial (FA aislada promueve cambios electrofisiológicos llamados "remodelación eléctrica", que facilitan su recurrencia y mantenimiento. Hay evidencia de que el proceso de remodelación sea reversible tras la recuperación del ritmo sinusal (RS. Sin embargo, el momento para la recuperación de las propiedades electrofisiológicas no está definido todavía. OBJETIVO: El objetivo de ese estudio fue evaluar la activación eléctrica atrial con el empleo del electrocardiograma de alta resolución de onda P (P-ECGAR postcardioversión de la FA de larga

  15. A refratariedade das aves ao "Trypanosoma (Schizotrypanum cruzi" I. ausência de passagem para o sangue; duração da viabilidade e destruição dos parasitos na pele The refractory State of birds toward the "Trypanosoma (Schizotrypanum Cruzi": I. Lack of transfer of parasites to the blood. Duration of viability and destruction of the parasites in the skin

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    F. Nery-Guimarães

    1972-01-01

    Full Text Available Quatro frangos e três pombos (1ª e 2ª experiências não se infectaram com o "T. (S. cruzi" (amostra Y, injetados na pele com doses de 9,8 x10*5 a 3,8 x 10*6 parasitos (mistura de formas de cultivo tripomastigotos sangüíneos. Em outros 2 frangos (6ª experiência, a refratariedade não foi rompida com, respectivamente, 5 injeções peritoneais em dias alternados, de 2,8 x 10*6 a 6,1 x 10*6 parasitos, e 5 injeções peritoneais diárias do conteúdo de um cultivo suspenso em salina, adicionado de tripamastigotos sangüíneos, obtidos de 3 camundongos jovens infectados. E, ainda em outros 2 frangos (7ª experiência, a refratariedade não foi rompida associando-se a doses peritoneais de 8,1 x 10*6 e 3,5 x 10*7 parasitos, respectivamente, a ministração de dexametasona, seja com o início da droga no mesmo dia da inoculação (0,4 mg/8 doses/10 dias, seja com o ínicio da droga 3dias antes do dia da inoculação (0,4 mg/10 doses/12 dias. Nessas 11 aves a refratariedade foi comprovada pela inoculação do sangue em camundongos albinos recém-nascidos (total de 54 inoculaçoes negativas em 301 camundongos; e por 52 xenodiagnósticos negativos (total de 175 larvas e adultos de Triatoma infestans e Panstrongylys megistus. As inoculações e os xenodiagnósticos foram feitos entre 1 hora (h e 96 h e aos 10, 20 e 30 dias depois da inoculação das aves. (Quadro 1. Portanto, além da refratariedade, ficou demonstrado que os parasitos não passam para o sangue circulante das aves. em 10 frangos (3ª, 4ª e 5ª experiências inoculados na pele com, 1,9 x 10*6 a 3,7 x 10*6 parasitos, verificou-se a duração da viabilidade dos parasitos nas áreas injetadas. Estas foram puncionadas de 1/2 com 1/2 hora, e o material obtido microscopado e inoculado em camundongos recém-nascidos. De 17 inoculações feitas até às 8:30 h, doze foram positivas, inclusive a última; e de 13 inoculações feitas entre 9 e 90 h (as 4 primeiras ainda de 1/2 em 1/2 h, todas

  16. Expression and Characterization of Purinergic Receptors in Rat Middle Meningeal Artery–Potential Role in Migraine

    DEFF Research Database (Denmark)

    Haanes, Kristian Agmund; Edvinsson, Lars

    2014-01-01

    The dura mater and its vasculature have for decades been central in the hypothesis of migraine and headache pathophysiology. Although recent studies have questioned the role of the vasculature as the primary cause, dural vessel physiology is still relevant in understanding the complex pathophysio......The dura mater and its vasculature have for decades been central in the hypothesis of migraine and headache pathophysiology. Although recent studies have questioned the role of the vasculature as the primary cause, dural vessel physiology is still relevant in understanding the complex...... be inhibited by SCH58261 (A2A receptor antagonist) and caffeine (adenosine receptor antagonist). This gives one putative molecular mechanism for the effect of caffeine, often used as an adjuvant remedy of cranial pain. Semi-quantitative RT-PCR expression data for the receptors correlate well...

  17. Double spinal dural sheath: a cadaveric case report

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    Loughenbury P

    2010-03-01

    Full Text Available A previously unreported variation in the anatomy of the spinal dural sheath was observed during routine cadaveric dissection, consisting of a duplication of the dural layer, with layers adherent throughout their length. The double dural sheath completely enveloped the spinal cord and nerve roots, and extended from C2 to L5: both layers were of similar thickness to a single dural sheath. Duplication of the dura mater in the form of two complete dural sheaths has not been previously observed and/or reported in a cadaveric study. However, areas of localised duplication of the ventral aspect of the dural sheath have been observed during intra-operative dissection, particularly in association with idiopathic herniation of the spinal cord. Complete duplication of the spinal dura mater is of clinical interest in spinal surgery, particularly in relation to idiopathic spinal cord herniation.

  18. Optical properties of animal tissues in the wavelength range from 350 to 2600 nm

    Science.gov (United States)

    Filatova, Serafima A.; Shcherbakov, Ivan A.; Tsvetkov, Vladimir B.

    2017-03-01

    The optical properties of different cow and pig biological tissues such as skeletal muscle, adipose, spinal cord, and dura mater of the spinal cord were investigated in the spectral range of 350 to 2600 nm. The measurements were carried out by a commercially available spectrophotometer SHIMADZU UV 3101PC. The wavelength dependence on the scattering coefficient has been observed to follow a power-law decay for skeletal muscle and dura mater of spinal cord. The influence of time delay between the sample preparation and measuring of transmittance spectra on the data reasonableness was reviewed. The conclusion about the benefits of 2-μm lasers application in surgery is given for the tissue types listed above.

  19. Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion

    DEFF Research Database (Denmark)

    Lukács, M; Haanes, K A; Majláth, Zs

    2015-01-01

    induces inflammatory activation in the trigeminal ganglion. METHODS: We performed topical administration of inflammatory soup (IS) or Complete Freund's Adjuvant (CFA) onto an exposed area of the rat dura mater in vivo for 20 min. The window was closed and the rats were sacrificed after 4 h and up to 7...... days. Myography was performed on middle meningeal arteries. The trigeminal ganglia were removed and processed for immunohistochemistry or Western blot. RESULTS: Both CFA and IS induced enhanced expression of pERK1/2, IL-1β and CGRP in the trigeminal ganglia. The pERK1/2 immunoreactivity was mainly seen...... vasoconstrictor response to IS, but not to CFA. CONCLUSIONS: These results suggest that the application of IS or CFA onto the dura mater causes long-term activation of the TG and demonstrate the importance of the neuro-glial interaction in the activation of the trigeminovascular system....

  20. Micro-computed tomography study of the abnormal osseous extensions of sella turcica.

    Science.gov (United States)

    Skrzat, J; Kozerska, M; Wróbel, A

    2014-02-01

    The paper presents anatomical considerations on the abnormal ossification, which occurred around the dorsum of the sella turcica in the human skull of the female individual. Probably the morphological alterations of the sellar region were associated with extensive heterotopic ossification of the dura mater attached to the dorsum of the sella turcica and the posterior clinoid processes. The analysis of gray values of the voxels representing the areas of abnormal ossification indicated on variation in bone density in the entire sample. We have established that the highest mineralisation of bony tissue occurred in the marginal parts of the osseous extensions deriving from the posterior clinoid processes. The ossified parts of dura mater attached to the posterior clinoid processes showed significantly higher content of the hydroxyapatite (1.9 g/cm3) than the dorsum of the sella turcica (1.0 g/cm3).

  1. Effects of Millimeter-Wave Electromagnetic Radiation on the Experimental Model of Migraine.

    Science.gov (United States)

    Sivachenko, I B; Medvedev, D S; Molodtsova, I D; Panteleev, S S; Sokolov, A Yu; Lyubashina, O A

    2016-02-01

    Effects of millimeter-wave electromagnetic radiation (40 GHz frequency, 0.01 mW power) on the spontaneous fi ring of convergent neurons of the spinal trigeminal nucleus and their responses to electrical stimulation of the dura mater were studied in neurophysiological experiments on rats. Irradiation of the area of cutaneous receptive fields of spinal trigeminal nucleus reversibly inhibited both spontaneous discharges and activity induced by electrical stimulation of the dura mater. The second and third exposures to electromagnetic radiation with an interval of 10 min were ineffective. These results suggest that suppression of neuronal excitability in the spinal trigeminal ganglion can be a mechanism of the anti-migraine effects of electromagnetic radiation observed in clinical practice.

  2. Traumatic Brain Injury: A Guide for Caregivers of Service Members and Veterans

    Science.gov (United States)

    2010-01-01

    Diplopia (Double Vision) - Companion, page 4; Module 2, page 21 Disability Concurrent Retirement and...DTAP) - Module 4, pages 115-116 Discharge with Severance Pay - Module 4, pages 78, 84 Dizziness - Module 2, pages 18-20 Double Vision ( Diplopia ... Diplopia – Seeing two images of a single object; double vision. Dura Mater – The outermost of three membranes protecting the brain and spinal cord.

  3. DoD Numbers for Traumatic Brain Injury

    Science.gov (United States)

    2013-11-01

    Penetrating TBI, or open head injury, is characterized by the following: A head injury in which the dura mater, the outer layer of the meninges , is...information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and...maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other

  4. Spontaneous intracranial epidural hematoma during rivaroxaban treatment

    Energy Technology Data Exchange (ETDEWEB)

    Ruschel, Leonardo Gilmone; Rego, Felipe Marques Monteiro do; Milano, Jeronimo Buzetti; Jung, Gustavo Simiano; Silva Junior, Luis Fernando; Ramina, Ricardo, E-mail: leonardoruschel@yahoo.com.br [Instituto de Neurologia de Curitiba (INC), Curitiba, PR (Brazil)

    2016-11-15

    According to our research, this is the first case described in the literature of spontaneous intracranial epidural hematoma secondary to the use of Xarelto®. Spontaneous intracranial epidural hematomas are rarely described in the literature. They are associated with infectious diseases of the skull, coagulation disorders, vascular malformations of the dura mater and metastasis to the skull. Long-term post-marketing monitoring and independent reports will probably detect the full spectrum of hemorrhagic complications of the use of rivaroxaban. (author)

  5. Bilateral Vision Loss Secondary to Pachymeningitis in a Patient with IgG4-Related Disease

    Directory of Open Access Journals (Sweden)

    Lucas eRamirez

    2014-10-01

    Full Text Available IgG4-Related Disease is a recently recognized fibroinflammatory condition associated with disease in nearly every organ, including the meninges. A proportion of Idiopathic Hypertrophic Pachymeningitis cases may involve a component of meningeal IgG4-RD. We present a patient with severe bilateral vision loss found to have thickening of the dura mater on MRI, and subsequently diagnosed with IgG4-RD after dural biopsy.

  6. A Reusable Adapter for Collection of Cerebrospinal Fluid in Chronically Cannulated Goats

    Science.gov (United States)

    1989-03-03

    implantation of the cisternal cannula, a 7mm hole was trephined ventrally through the base of the occipital bone to the dorsal surface of the dura mater in...cannula and over the screws used for anchoring the resin. The stereotaxic equipment was used to center the cannulas into the trephined holes as well as for...suture and extended 2cm laterally on each side of the midline. The lateral ventricular cannula (Figure 3) was introduced through a 9mm hole trephined

  7. Brain Herniation into Giant Arachnoid Granulation: An Unusual Case

    Science.gov (United States)

    Santos, Gonçalo Roque

    2017-01-01

    Arachnoid granulations are structures filled with cerebrospinal fluid (CSF) that extend into the venous sinuses through openings in the dura mater and allow the drainage of CSF from subarachnoid space into venous system. Usually they are asymptomatic but can be symptomatic when large enough to cause sinus occlusion. We report a rare case of a brain herniation into a giant arachnoid granulation in an asymptomatic elderly male patient, which was discovered incidentally. PMID:28392955

  8. A study on the occurrence of alkaline phosphatase in the sutura interfrontalis of Wistar rats.

    Science.gov (United States)

    Markens, I S; Oudhof, H A

    1979-01-01

    The aim of the present study was to determine the presence of alkaline phosphatase during various stages in development and closure of the sutura interfrontalis. The histological sections reveal that this enzyme could primarily be demonstrated in the dura mater of this suture. In further developmental stages, alkaline phosphatase could be observed within the intermediate zone as well as the pericranium. These findings are brought in relation with the occurrence of synostosis which can be induced under experimental conditions.

  9. Leakage of cerebrospinal fluid and secondary intracranial infection induced by Cloward technique of cervical discectomy and fusion: presentation and treatment

    Institute of Scientific and Technical Information of China (English)

    GUO Hong-bin; YANG Shu-xu; WANG Yi-rong

    2008-01-01

    @@ Cloward technique of cervical discectomy and fusion is a long and complex surgical proce dure and instrumentation, by which compli-cated infection is rare in an era of routine prophylactic antimicrobial agent, especially in procedures by anterior approach. A study in the journal of Spine suggested that the incidence of unintentional laceration of the dura mater during spinal surgery might be as high as 14%.

  10. Comparison between two surgical techniques for prenatal correction of meningomyelocele in sheep

    OpenAIRE

    Herrera,Silvia Rejane Fontoura; Leme,Ricardo José de Almeida; Valente, Paulo Roberto [UNIFESP; Caldini,Élia Garcia; Saldiva, Paulo Hilário Nascimento; Pedreira, Denise Araujo Lapa

    2012-01-01

    OBJECTIVE: To compare the classical neurosurgical technique with a new simplified technique for prenatal repair of a myelomeningocelelike defect in sheep. METHODS: A myelomeningocele-like defect (laminectomy and dural excision) was created in the lumbar region on day 90 of gestation in 9 pregnant sheep. Correction technique was randomized. In Group 1 the defect was corrected using the classic neurosurgical technique of three-layer suture (dura mater, muscle and skin closure) performed by a ne...

  11. Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38

    DEFF Research Database (Denmark)

    Baun, Michael; Pedersen, Martin Holst Friborg; Olesen, Jes;

    2012-01-01

    but not VIP cause degranulation of mast cells in peritoneum and in dura mater. METHODS: The degranulatory effects of PACAP-38, PACAP-27 and VIP were investigated by measuring the amount of N-acetyl-β-hexosaminidase released from isolated peritoneal mast cells and from dura mater attached to the skull...... of the rat in vitro. In peritoneal mast cells N-truncated fragments of PACAP-38 (PACAP(6–38), PACAP(16–38) and PACAP(28–38)) were also studied. To investigate transduction pathways involved in mast cell degranulation induced by PACAP-38, PACAP-27 and VIP, the phospholipase C inhibitor U-73122...... and the adenylate cyclase inhibitor SQ 22536 were used. RESULTS: The peptides induced degranulation of isolated peritoneal mast cells of the rat with the following order of potency: PACAP-38 = PACAP(6–38) = PACAP(16–38) » PACAP-27 = VIP = PACAP(28–38). In the dura mater we found that 10–5 M PACAP-38...

  12. Dural attachment of intracranial meningiomas: evaluation with contrast-enhanced three-dimensional fast imaging with steady-state acquisition (FIESTA) at 3 T

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Junkoh; Takahashi, Mayu; Aoyama, Yuichi; Soejima, Yoshiteru; Saito, Takeshi; Akiba, Daisuke; Nishizawa, Shigeru [University of Occupational and Environmental Health, Department of Neurosurgery, Kitakyusyu (Japan); Kakeda, Shingo; Korogi, Yukunori [University of Occupational and Environmental Health, Department of Radiology, Kitakyusyu (Japan)

    2011-06-15

    The purpose of this study was to evaluate the role of contrast-enhanced fast imaging with steady-state acquisition (CE-FIESTA) for assessing whether dural attachment in intracranial meningiomas is adhesive or not by correlation with intraoperative findings. Fourteen consecutive patients who were candidates for surgical treatment of meningiomas were prospectively analyzed with preoperative magnetic resonance imaging, including CE-FIESTA at 3 T. First, two neuroradiologists assessed several characteristics of the attachment of the meningioma to the dura mater or skull base on CE-FIESTA images. Second, the surgical findings of adhesion at the dural attachment of meningiomas were evaluated by two neurosurgeons. Finally, the CE-FIESTA findings were correlated with the surgical findings by one neurosurgeon and one neuroradiologist by consensus. CE-FIESTA clearly depicted a hypointense marginal line at the attachment site of the meningioma. When CE-FIESTA revealed smooth marginal lines or hyperintense zones along the marginal lines, tumors were detached easily from the dura mater. On the contrary, when CE-FIESTA showed an irregularity, such as partial disruption of the marginal lines, vessels, or bony hyperostosis, the tumors tended to adhere firmly to the dura mater, which was found to contain small vessels and fine fibrous tissues. There seems to be an excellent correlation between the characteristics of dural attachment of meningiomas on CE-FIESTA images and intraoperative findings. Therefore, for operative planning, CE-FIESTA may provide useful information regarding the adhesiveness of dural attachment. (orig.)

  13. Dural attachment of intracranial meningiomas: evaluation with contrast-enhanced three-dimensional fast imaging with steady-state acquisition (FIESTA) at 3 T.

    Science.gov (United States)

    Yamamoto, Junkoh; Kakeda, Shingo; Takahashi, Mayu; Aoyama, Yuichi; Soejima, Yoshiteru; Saito, Takeshi; Akiba, Daisuke; Korogi, Yukunori; Nishizawa, Shigeru

    2011-06-01

    The purpose of this study was to evaluate the role of contrast-enhanced fast imaging with steady-state acquisition (CE-FIESTA) for assessing whether dural attachment in intracranial meningiomas is adhesive or not by correlation with intraoperative findings. Fourteen consecutive patients who were candidates for surgical treatment of meningiomas were prospectively analyzed with preoperative magnetic resonance imaging, including CE-FIESTA at 3 T. First, two neuroradiologists assessed several characteristics of the attachment of the meningioma to the dura mater or skull base on CE-FIESTA images. Second, the surgical findings of adhesion at the dural attachment of meningiomas were evaluated by two neurosurgeons. Finally, the CE-FIESTA findings were correlated with the surgical findings by one neurosurgeon and one neuroradiologist by consensus. CE-FIESTA clearly depicted a hypointense marginal line at the attachment site of the meningioma. When CE-FIESTA revealed smooth marginal lines or hyperintense zones along the marginal lines, tumors were detached easily from the dura mater. On the contrary, when CE-FIESTA showed an irregularity, such as partial disruption of the marginal lines, vessels, or bony hyperostosis, the tumors tended to adhere firmly to the dura mater, which was found to contain small vessels and fine fibrous tissues. There seems to be an excellent correlation between the characteristics of dural attachment of meningiomas on CE-FIESTA images and intraoperative findings. Therefore, for operative planning, CE-FIESTA may provide useful information regarding the adhesiveness of dural attachment.

  14. Epidural anterior petrosectomy with subdural visualization of sphenobasal vein via the anterior transpetrosal approach--technical case report.

    Science.gov (United States)

    Ichimura, Shinya; Yoshida, Kazunari; Kagami, Hiroshi; Inaba, Makoto; Orii, Maaya; Kitamura, Yohei; Saga, Isako; Toda, Masahiro

    2012-10-01

    The drainage of the superficial middle cerebral vein (SMCV) is classified into four subtypes. The sphenobasal vein (SBV) drains from the SMCV to the pterygoid venous plexus at the temporal skull base. Epidural procedures in the standard anterior transpetrosal approach (ATPA) may damage the route of the SBV. We report a case in which modified surgical procedures via the ATPA were used to preserve the SBV. A 45-year-old man complained of right facial pain. Magnetic resonance images revealed a right cerebellopontine tumor suggestive of an epidermoid cyst. Right carotid angiography revealed that the SMCV drained into the pterygoid venous plexus via the SBV. The convexity dura mater of the temporal lobe was cut and the anterior part of the temporal lobe was retracted subdurally. The SBV was visualized from the subdural side. The basal dura mater of the temporal lobe posterior to the SBV was cut and the posterior part of the temporal lobe was retracted epidurally. After dissecting the dura mater medial to the greater petrosal nerve and to the edge of the petrous apex, the petrous apex was exposed and drilled out without injuring the SBV. The superior petrous sinus and the tentorium were cut. The tumor compressed the root exit zone of the trigeminal nerve. The tumor was grossly totally removed. The modified ATPA (epidural anterior petrosectomy with subdural visualization of the SBV) is effective in preserving the SBV.

  15. Novel dural incision and closure procedure for preventing postoperative cerebrospinal fluid leakage during the surgical removal of dumbbell-shaped spinal tumors: technical note.

    Science.gov (United States)

    Ito, Kiyoshi; Aoyama, Tatsuro; Nakamura, Takuya; Hanaoka, Yoshiki; Horiuchi, Tetsuyoshi; Hongo, Kazuhiro

    2016-11-01

    The authors report on a new method for removing dumbbell-shaped spinal tumors that avoids the risk of postoperative cerebrospinal fluid (CSF) leakage. Adequate visualization of the intra- and extradural components of the tumor is achieved with the use of separate dural incisions. First, the dura mater is opened along the dural theca to provide adequate visualization of the intradural portion of the mass; then, a second incision is made along the nerve root to remove the extradural component. Meticulous suturing is essential in intradural lesion cases; however, the dura mater is usually thin and fragile in such cases. During suturing with a needle and thread, the dura mater can become lacerated proximal to the needle holes and result in CSF leakage. In the authors' technique, instead of using a needle and thread, nonpenetrating vascular clips were used to close the dural incisions. When operating on dumbbell-shaped spinal tumors, the authors found that the "separate-dural-incision method" was preferable to the conventional T-shaped dural incision method because no dural defects occurred after the intradural procedure and meticulous dural closure with vascular clips was achieved. The authors conclude that the novel separate-dural-incision method for removing dumbbell-shaped tumors and the use of nonpenetrating vascular clips permits reliable dural closure, prevents postoperative CSF leakage, and promises good postoperative clinical results.

  16. Concurrent spinal schwannoma and meningioma mimicking a single cervical dumbbell-shaped tumor: case report.

    Science.gov (United States)

    Oichi, Takeshi; Chikuda, Hirotaka; Morikawa, Teppei; Mori, Harushi; Kitamura, Daisuke; Higuchi, Junya; Taniguchi, Yuki; Matsubayashi, Yoshitaka; Oshima, Yasushi; Tanaka, Sakae

    2015-12-01

    Dumbbell-shaped tumors consisting of 2 different tumors are extremely rare. Herein, the authors present a case of concurrent spinal schwannoma and meningioma mimicking a single cervical dumbbell-shaped tumor. A 64-year-old man presented with a 5-year history of gradually exacerbating left occipital pain without clinical evidence of neurofibromatosis. Magnetic resonance imaging showed an extradural tumor along the left C-2 nerve root with a small intradural component. The tumor was approached via a C-1 hemilaminectomy. The intradural tumor was resected together with the extradural tumor after opening the dura mater. The intradural tumor was attached to the dura mater around the exit point of the C-2 nerve root. Intraoperative biopsy revealed that the extradural tumor was a schwannoma and that the intradural tumor was a meningioma. The dura mater adjacent to the tumor was then coagulated and resected. Postoperative pathological examination confirmed the same diagnoses with no evidence of continuity between the intra- and extradural components. The patient's postoperative clinical course was uneventful. Clinicians should be aware that cervical dumbbell-shaped tumors can consist of 2 different tumors.

  17. Concurrent spinal nerve root schwannoma and meningioma mimicking single-component schwannoma.

    Science.gov (United States)

    Nakamizo, Akira; Suzuki, Satoshi O; Shimogawa, Takafumi; Amano, Toshiyuki; Mizoguchi, Masahiro; Yoshimoto, Koji; Sasaki, Tomio

    2012-04-01

    We present a first case of concurrent tumors consisting of schwannoma and meningioma arising at the same spinal level in a patient without neurofibromatosis. A 49-year-old man without clinical evidence of neurofibromatosis presented with a 5-month history of right neck pain. MRI demonstrated an extradural tumor involving the right-sided C2 nerve root with a small intradural component. T1- and T2-weighted and contrast-enhanced MRI could not differentiate the intradural tumor as different from the extradural tumor. Total removal of the tumors was performed. No contiguity of the extradural tumor with the intradural tumor was seen. The intradural tumor attached strongly to the dura mater around the C2 nerve root exits. Intraoperative pathological diagnosis confirmed the extradural tumor as schwannoma and the intradural tumor as meningioma. We therefore thoroughly coagulated the dura mater adjacent to the intradural tumor and resected the dura mater around the nerve root exits together with the tumor. Pathological examination revealed that the resection edge of the extradural component consisted of a spinal nerve with thickened epineurium and was free of neoplastic cells. No schwannoma component was evident in the intradural tumor. No obvious transition thus existed between the extra- and intradural tumors. Distinguishing these tumors prior to surgery is critical for determining an optimal surgical plan, as schwannoma and meningioma require different surgical procedures. We therefore recommend a careful review of preoperative imaging with the possibility of concurrent tumors in mind. © 2011 Japanese Society of Neuropathology.

  18. Hypertrophic cranial pachymeningitis in a patient with aplastic anemia.

    Science.gov (United States)

    Asano, T; Hayashida, M; Ogawa, K; Adachi, K; Teramoto, A; Yamamoto, M

    1998-12-01

    We report on a 13-year old girl with severe aplastic anemia and hypertrophic cranial pachymeningitis. She was admitted to our hospital with severe headache and vomiting. A computerized tomographic (CT) scan of the brain on the third day of symptoms showed a hyperdense area in the tentorial region. Magnetic resonance imaging (MRI) showed iso-intensity in the same tentorial region in T1- and T2-weighted images, and gadolinium enhancement of this region suggested a thickened dura mater. Initially, a diagnosis of subdural or subarachnoid hemorrhage was made. Since her platelet count was low (3000/microl) making the patient a poor-risk candidate for surgery, and the area was limited to the dura mater, conservative therapy, including glycerol administration and platelet transfusion, was carried out. Despite clinical improvement 10 days after admission without specific therapy, the iso-intense region on the left side of the tentorial region remained unchanged on MRI. On the other hand, the iso-intense area on the right side of the tentorial region became hyperdense on T1-weighted MRI images and was also enhanced by gadolinium. Cerebrospinal fluid findings were normal except for slightly elevated protein at 62 mg/dl. A diagnosis of hypertrophic cranial pachymeningitis of the tentorial dura mater with hemorrhage on the right side was made. Although hypertrophic cranial pachymeningitis is a rare disease, it must be considered in the differential diagnosis of severe headache in a case of aplastic anemia.

  19. No mutations found in exons of TP53, H-RAS and K-RAS genes in liver of male Wistar rats submitted to a medium-term chemical carcinogenesis assay Ausência de mutações em éxons dos genes TP53, H-RAS e K-RAS em fígado de ratos wistar submetidos a ensaio de carcinogênese química de média duração

    Directory of Open Access Journals (Sweden)

    Erick da Cruz Castelli

    2002-07-01

    Full Text Available The standard protocol to evaluate the carcinogenic potential of chemicals is the long-term bioassay in rodents, not performed in developing countries due to its high cost and complex operational procedures. Our laboratory has established an alternative medium-term bioassay in Wistar rats, also called DMBDD assay, based on the paradigm initiation/promotion of chemical carcinogenesis. This method was accepted by the Brazilian Environment Agency (IBAMA as an official source of evidence of carcinogenicity. The aim of this study was to evaluate alterations in exons 5 to 8 of the tumor suppressor gene TP53 and exons 1 and 2 of oncogenes K-RAS and H-RAS in neoplastic and preneoplastic hepatic lesions observed in DMBDD assay. The characterization of these alterations may contribute to the recognition of patterns of damage in critical genes, as well as to suggest mechanisms of action of the compounds tested in the protocol. Sixty male Wistar rats were separated into 3 groups: the first was treated with no chemicals; the second received five initiating agents and the third received initiation followed by phenobarbital. Liver DNA samples (obtained from formalin-fixed and paraffin-embedded tissues after histological analysis were evaluated by the non-isotopic PCR-SSCP technique. No changes in any analyzed exons were detected by the PCR-SSCP banding pattern in all experimental groups. This result suggests that liver mutations in exons 5 to 8 of TP53 and exons 1 and 2 of H-RAS and K-RAS are not among the early molecular alterations occurring in the hepatic carcinogenesis process induced by the DMBDD protocol in male Wistar rats.O teste padrão para identificar o potencial cancerígeno de compostos químicos é o estudo de longa duração em roedores, não realizado no Brasil. Nosso laboratório estabeleceu um teste alternativo de média duração (ensaio DMBDD, baseado no paradigma iniciação-promoção da carcinogênese química, adotado pelo Instituto

  20. Avaliação do impacto da polimedicação nas verbas de internamento nas unidades de longa duração e manutenção Evaluación del impacto de la polimedicación sobre la financiación de las unidades de hospitalización y mantenimiento a largo plazo Assessment of the impact of polypharmacy on funding for admission in a long-term care and maintenance unit

    Directory of Open Access Journals (Sweden)

    Nelson Manuel de Lima Ferreira

    2012-03-01

    Full Text Available Contexto: a falência dos estados de providência obriga a que seja efetuada uma reflexão e análise cuidada de todo o campo da saúde para que a sua sustentabilidade seja possível. Em Portugal verifica-se, como em toda a Europa, um progressivo envelhecimento da população, consequência do aumento da esperança média de vida e da baixa natalidade. Objetivos: avaliar o impacto da polimedicação nas verbas diárias de internamento imputadas a uma unidade de longa duração e manutenção. Método: tratou-se de um estudo de caso, de natureza exploratória, junto de 65 utentes, admitidos na Unidade de Longa Duração e Manutenção Dona Elvira da Câmara Lopes da Santa Casa da Misericórdia da Póvoa de Lanhoso. Resultados: existe polimedicação major nesta população, nomeadamente, uma média de 6 medicamentos prescritos por utente. Fazendo o cálculo, em função de 10 EUR de verba diária atribuída, obtém-se a percentagem significativa de 37% de impacto na verba imputada pelo Estado. Conclusão: é preciso compreender os padrões de prescrição noutros contextos, assim como, conhecer as razões/motivos que levam à prescrição de mais do que um fármaco.Contexto: el fracaso de los Estados sociales obliga a que se entame una reflexión y un cuidadoso análisis de todo el campo de la salud para que su sostenibilidad sea posible. En Portugal hay, como en otras partes de Europa, un progresivo envejecimiento de la población, consecuencia de la mayor esperanza de vida y baja tasa de natalidad. Objetivos: evaluar el impacto de la polimedicación en los gastos diarios de ingreso imputados a una unidad de hospitalización de Largo Plazo y de Mantenimiento. Método: se realizó un estudio de caso de carácter exploratorio, con 65 usuarios, ingresados en la unidad de hospitalización a Largo Plazo y de Mantenimiento - Dona Elvira da Câmara Lopes de la Santa Casa da Misericórdia da Póvoa de Lanhoso. Resultados: hay una mayor polimedicaci

  1. Watertight dural closure! An in vitro study to explore the myth

    Directory of Open Access Journals (Sweden)

    Sudipkumar Sengupta

    2013-01-01

    Full Text Available Aim: The watertight closure of the dura mater is fundamental to intracranial supratentorial procedures in neurosurgery. Controversies exist claiming the superiority of one closure technique over another. But is ′Water-tight′ dural closure really achievable ? An in vitro study system was developed to test the pressures at which dural incisions, closed with sutures, leaked. Materials and Methods: Bovine dura was secured to the lower end of an open ended calibrated plastic cylinder. Multiple interrupted stitches were applied over a two 2 cm length of the dura without any incision. Similarly a 2 cm incision was made and closed with interrupted and continuous stitches. Cylinder was filled with colored saline gradually. Height of the water column at which sutured dura leaked was recorded. The tests were conducted with the dura both in lax and tense conditions. Inlay closure technique was also tested on the same model using a dural substitute. Results: Even without an incision, needle puncture sites over a dura, leak, at a very low hydrostatic pressure (30 < mm of H2O, though a continuous interlocking suture performs slightly better than an interrupted suture technique. If the needle puncture sites are closed with glue, both the suture techniques can achieve a watertight closure against a hydrostatic pressure of 240 mm of H2O. Conclusion : In the experimental model described, ′Water-tight′ dural closure appears to be impossible with suture closure of a dural defect.

  2. Optogenetics through windows on the brain in the nonhuman primate.

    Science.gov (United States)

    Ruiz, Octavio; Lustig, Brian R; Nassi, Jonathan J; Cetin, Ali; Reynolds, John H; Albright, Thomas D; Callaway, Edward M; Stoner, Gene R; Roe, Anna W

    2013-09-01

    Optogenetics combines optics and genetics to control neuronal activity with cell-type specificity and millisecond temporal precision. Its use in model organisms such as rodents, Drosophila, and Caenorhabditis elegans is now well-established. However, application of this technology in nonhuman primates (NHPs) has been slow to develop. One key challenge has been the delivery of viruses and light to the brain through the thick dura mater of NHPs, which can only be penetrated with large-diameter devices that damage the brain. The opacity of the NHP dura prevents visualization of the underlying cortex, limiting the spatial precision of virus injections, electrophysiological recordings, and photostimulation. Here, we describe a new optogenetics approach in which the native dura is replaced with an optically transparent artificial dura. This artificial dura can be penetrated with fine glass micropipettes, enabling precisely targeted injections of virus into brain tissue with minimal damage to cortex. The expression of optogenetic agents can be monitored visually over time. Most critically, this optical window permits targeted, noninvasive photostimulation and concomitant measurements of neuronal activity via intrinsic signal imaging and electrophysiological recordings. We present results from both anesthetized-paralyzed (optical imaging) and awake-behaving NHPs (electrophysiology). The improvements over current methods made possible by the artificial dura should enable the widespread use of optogenetic tools in NHP research, a key step toward the development of therapies for neuropsychiatric and neurological diseases in humans.

  3. Surgical resection without dural reconstruction of a lumbar meningioma in an elderly woman

    Science.gov (United States)

    Takahashi, Jun; Kato, Hiroyuki; Ebara, Sohei; Takahashi, Hideto

    2009-01-01

    Meningiomas of the spine occur in the thoracic spine in approximately 80%, followed in frequency by the cervical and lumbar regions. The treatment of spinal meningiomas is complete surgical resection. As intraspinal meningiomas are almost always adherent to the dura, extensive dural resection or diathermic treatment of the dural attachment is usually performed to prevent tumor recurrence. The authors present the case of lumbar spinal meningioma in 82-year-old woman. Successful resection with preservation of the dura mater using the technique of Saito et al. (Spine 26:1805-1808, 2001) is described: After lumbar laminectomy a small incision was made in the surface of the spinal dura. The dura mater was separated into its inner and outer layers, and the tumor was resected with inner layer alone, preserving the outer layer. The outer layer is simply closed to achieve a watertight seal. The pathologic diagnosis was metaplastic (osseous) meningioma. Almost full recovery of the neurologic deficit was attained. Neither complication nor tumor recurrence has occurred in the 5 years since surgery. Dural preservation during surgical resection of spinal meningioma obviates the need for dural reconstruction and should reduce surgical morbidity. However, the patient should be followed long-term to watch for recurrence. PMID:19219468

  4. Respostas agudas imediatas e tardias da flexibilidade na extensão do ombro em relação ao número de séries e duração do alongamento Respuestas agudas inmediatas y tardías de la flexibilidad en la extensión del hombro en relación a un número de séries y duración del elongamiento Immediate and late acute responses of flexibility in the shoulder extension in relation to the number of series and stretching duration

    Directory of Open Access Journals (Sweden)

    Luís Viveiros

    2004-12-01

    Full Text Available O objetivo do estudo foi investigar a relação entre número de séries e duração do exercício de alongamento da extensão do ombro sobre os efeitos agudos imediatos e tardios na flexibilidade. Setenta indivíduos com idade entre 20 e 30 anos sem treinamento prévio em flexibilidade participaram do estudo. Aleatoriamente, 10 sujeitos compuseram o grupo controle (GC e os demais foram divididos igualmente em três grupos, de acordo com a duração do estímulo, a saber: 10 segundos (G10, 60 segundos (G60 e 120 segundos (G120. Posteriormente, cada grupo foi subdivido em relação ao número de séries, a saber: uma (G10A, G60A, G120A e três séries (G10B, G60B, G120B. A flexibilidade foi medida por um goniômetro universal e as observações ocorreram imediatamente após, 90 minutos após e 24 horas depois do estímulo. A ANOVA identificou associação significativa entre o tempo de estímulo e demais variáveis (p = 0,042. Não se verificaram diferenças de flexibilidade entre os grupos experimentais, mas todos exibiram valores maiores que os do GC. A comparação temporal dos valores absolutos de flexibilidade, para os grupos submetidos à mesma duração de estímulo e número de séries, revelou diferenças significativas apenas para G120A, G60B e G120B, entre a primeira observação e após 24 horas. Por outro lado, a análise dos valores percentuais mostrou que o tempo de estímulo e o número de séries associaram-se à duração do incremento agudo de flexibilidade. Nesse aspecto não houve diferenças entre os grupos, exceto entre G60A e G60B, na observação após 24 horas. Conclui-se que a duração do estímulo pode proporcionar maior flexibilidade inicial, independentemente do número de séries. Porém, os ganhos imediatos de flexibilidade não são mantidos após 24 horas. Não se sabe, porém, se estímulos sucessivos de longa duração proporcionariam maior amplitude em longo prazo em comparação com alongamentos realizados

  5. Retenção do dimetoato e sua relação com pH e teores de argila e matéria orgânica nos sedimentos da zona não-saturada de uma microbacia no nordeste paraense Dimethoate retention and its relation to pH, clay and organic mater contents by sediments in non saturated zone of a small catchment of the northeast Pará

    Directory of Open Access Journals (Sweden)

    Lilianne Maia Lima

    2007-06-01

    the Cumaru stream, Igarapé-Açu county, we evaluated the retention process of this compound in samples of the non saturated zone, as well as verified the effects of soil pH and clay and organic mater contents in this process. Among the main pesticides the farmers use in this region, dimethoate was selected for this study, due to its larger leaching potential according to the GUS (Groundwater Ubiquity Score index. A sorption experiment was carried out to evaluate the retention of the dimethoate in sediments in the non saturated zone. The experiment showed that the sorption of the dimethoate varied from 2.5% to 36.2% (initial concentration of 20 mg.l-1 and from 6.2% to 31.0% (initial concentration of 10 mg.l-1. These data demonstrate a high contamination potential of the groundwater by this compound, mainly due to its high mobility and low retention capacity. The dimethoate sorption rates were positively related to organic matter content in the sediments. On the other hand, values have an inverse relationship with the sorption rates of dimethoate, while clay content did not produce any effect on its retention.

  6. Estudo descritivo sobre a implantação da estratégia de tratamento de curta duração diretamente observado no controle da tuberculose em São José do Rio Preto e seus impactos (1998-2003 Descriptive study of the implementation and impact of the directly observed treatment, short-course strategy in the São José do Rio Preto municipal tuberculosis control program (1998-2003

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    Cláudia Eli Gazetta

    2007-04-01

    Full Text Available OBJETIVO: Descrever os resultados de tratamento (cura, abandono ou óbito após a implantação da estratégia de tratamento de curta duração diretamente observado (Directly Observed Treatment, Short-course - DOTS no controle da tuberculose em São José do Rio Preto, São Paulo, no período de 1998 a 2003. MÉTODOS: Estudo descritivo que utilizou fontes secundárias de informações (Sistema Nacional de Agravos de Notificação, Sistema de Notificação de Tuberculose, Livro de Registro/Livro Preto por meio de um instrumento específico. Os dados foram analisados por estatística descritiva. RESULTADOS: Após a implantação da estratégia DOTS houve uma diminuição das taxas de abandono e detecção de casos e um aumento das taxas de cura e óbito. O aumento do número de óbitos por tuberculose pode ter ocorrido devido a três fatores: o predomínio da doença em indivíduos acima de 50 anos; a co-infecção tuberculose/HIV e a presença de doenças associadas. CONCLUSÕES: A implantação da estratégia DOTS fortaleceu a descentralização das ações de controle da tuberculose e a integração das equipes das Unidades Básicas de Saúde com a equipe do Programa de Controle da Tuberculose. O compromisso político do gestor com o combate à tuberculose, aliado à política de benefícios e incentivos, é fundamental para a sustentabilidade da estratégia DOTS.OBJECTIVE: To describe treatment outcomes (cure, noncompliance or death after the implementation of the Directly Observed Treatment, Short-course (DOTS strategy for tuberculosis control in the city of São José do Rio Preto, Brazil, between 1998 and 2003. METHODS: A descriptive study, based on secondary data (National Case Registry database, Tuberculosis Epidemiology database, and the 'Black Book' Registry, was conducted using a specific instrument. The data were analyzed using descriptive statistics. RESULTS: After the implementation of the DOTS strategy, there was a decrease in

  7. Efeito da teofilina associada ao beta2-agonista inalatório de curta ou longa duração, em pacientes com doença pulmonar obstrutiva crônica estável: revisão sistemática Effect of theophylline associated with short-acting or long-acting inhaled beta2-agonists in patients with stable chronic obstructive pulmonary disease: a systematic review

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    Eliane Cristina Zacarias

    2007-04-01

    Full Text Available OBJETIVOS: Avaliar se o tratamento com teofilina associada ao beta2-agonista inalatório de curta ou longa duração é mais eficaz que o placebo e que o uso isolado de cada um dos fármacos, para os pacientes com doença pulmonar obstrutiva crônica estável. MÉTODOS: Realizou-se uma revisão sistemática com metanálise, sendo selecionados todos os ensaios clínicos aleatórios e duplo-cegos encontrados na literatura. RESULTADOS: Foram incluídos oito estudos. Teofilina associada ao beta2-agonista vs. placebo: houve melhora estatisticamente significante para o VEF1 (L, com média 0,27 (IC95% 0,11 a 0,43; e para a dispnéia, com média -0,78 (IC95% -1,26 a -0,29. Teofilina associada ao beta2-agonista vs. beta2-agonista isolado: nenhuma das metanálises realizadas detectou diferença entre os grupos. Teofilina associada ao beta2-agonista vs. teofilina isolada: houve melhora estatisticamente significante para a dispnéia, com média -0,19 (IC95% -0,34 a -0,04. CONCLUSÕES: Em pacientes com doença pulmonar obstrutiva crônica estável: 1 teofilina associada ao beta2-agonista é mais eficaz que o placebo, em relação ao VEF1 e dispnéia; 2a teofilina associada ao beta2-agonista é mais eficaz que a teofilina isolada, em relação à dispnéia; e 2b teofilina associada ao beta2-agonista não é mais eficaz que o beta2-agonista isolado, para quaisquer das variáveis estudadas.OBJECTIVES: To determine whether, in stable patients with chronic obstructive pulmonary disease, administration of theophylline in combination with short-acting or long-acting inhaled beta2-agonists is more efficacious than is a placebo or each of these drugs used in isolation. METHODS: A systematic review and meta-analysis were carried out. All randomized and double-blind clinical trials found in the literature were selected. RESULTS: A total of eight studies were included. In comparing the effect of theophylline combined with beta2-agonists to that of a placebo, we found a

  8. Análise de dois treinamentos com diferentes durações de pausa entre séries baseadas em normativas previstas para a hipertrofia muscular em indivíduos treinados Análisis de dos entrenamientos con diferentes duraciones de pausa entre las series basadas en normas previstas para la hipertrofia muscular en individuos entrenados Analysis of two training programs with different rest periods between series based on guidelines for muscle hypertrophy in trained individuals

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    Fernando Vitor Lima

    2006-08-01

    Full Text Available Os programas de treinamento na musculação são comumente prescritos baseando-se em normativas de carga de treinamento sugeridas pela literatura. Dentre as normativas, a prescrição da duração da pausa tem variado normalmente de um a três minutos. Comparações entre intervalos de pausa de um e três minutos mostram diferenças significativas na resposta hormonal, metabólica e no desempenho. Existe carência de estudos que mostram se diferentes pausas são suficientes para a realização das outras normativas previstas para o treinamento da hipertrofia e se um acréscimo de 30 segundos possibilita melhor recuperação. O objetivo deste estudo foi analisar a realização de dois treinamentos baseados em normativas previstas para a hipertrofia muscular e diferenciadas pelas pausas de 90 e 120 segundos entre séries, no exercício supino executado na barra guiada. Participaram 26 voluntários do sexo masculino, treinados em musculação. Foram realizadas quatro sessões de testes em quatro dias. Após a realização dos procedimentos de familiarização e do teste de 1RM, o grupo realizou o exercício no supino guiado à intensidade de 70% de 1RM em quatro séries com o objetivo de alcançar 12 repetições por série, com pausas de 90 ou 120 segundos distribuídas aleatoriamente em diferentes dias. Não foi verificada diferença significativa no número de repetições nas séries quando comparado o desempenho obtido pelos sujeitos nas duas pausas. Independente da duração da pausa (90 ou 120 segundos foi observada queda do rendimento no decorrer da realização das séries, caracterizada pela redução significativa no número de repetições realizado. Os resultados mostraram limitação da aplicação das normativas previstas para o treinamento da hipertrofia muscular em indivíduos treinados. Além disso, pode não haver diferenças no desempenho com a alteração da pausa entre séries de 90 para 120 segundos.Los programas de

  9. Nanoscale Electrodes: Nanoscale Electrodes for Flexible Electronics by Swelling Controlled Cracking (Adv. Mater. 30/2016).

    Science.gov (United States)

    Zhao, Qiang; Wang, Wenjun; Shao, Jinyou; Li, Xiangming; Tian, Hongmiao; Liu, Lu; Mei, Xuesong; Ding, Yucheng; Lu, Bingheng

    2016-08-01

    The fabrication of nanospaced electrodes on a flexible substrate is a great challenge. W. Wang, J. Shao, and co-workers propose a novel approach to fabricate nanogap electrodes for flexible electronics using a swelling-controlled cracking method, which is described on page 6337. This method has the advantages of high applicability, parallel manufacturing capacity, and compatibility with flexible substrates. It provides a new way to create high-performance flexible electronics in a cost-efficient fashion.

  10. Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction

    NARCIS (Netherlands)

    Nakagomi, Takayuki; Molnar, Zoltan; Nakano-Doi, Akiko; Taguchi, Akihiko; Saino, Orie; Kubo, Shuji; Clausen, Martijn; Yoshikawa, Hiroo; Nakagomi, Nami; Matsuyama, Tomohiro

    2011-01-01

    Increasing evidence shows that neural stem/ progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical

  11. Cross-modal associations between materic painting and classical Spanish music.

    Science.gov (United States)

    Albertazzi, Liliana; Canal, Luisa; Micciolo, Rocco

    2015-01-01

    The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar) music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and auditory stimuli, which predominantly analyzed single tones and colors by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and auditory stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical color. The results show that multisensory features expressed by adjectives such as "quick," "agitated," and "strong," and their antonyms "slow," "calm," and "weak" characterized both the visual and auditory stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness (major mode), or to feelings of sadness (minor mode), and spatial orientation (vertical and horizontal) did not play a significant role in the association. The consistency of the associations was shown when evaluated on the whole sample, and after considering the different backgrounds and expertise of the subjects. No substantial difference was found between expert and non-expert subjects. The methods used in the experiment (semantic differential and subjective judgements in first person account) corroborated the interpretation of the results as associations due to patterns of qualitative similarity present in stimuli of different sensory modalities and experienced as such by the subjects. The main result of the study consists in showing the existence of cross-modal associations between highly complex stimuli; furthermore, the second experiment employed a specific methodology based on subjective perceptual judgments.

  12. Cross-Modal Associations between Materic Painting and Classical Spanish Music

    Directory of Open Access Journals (Sweden)

    Liliana eAlbertazzi

    2015-04-01

    Full Text Available The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and acoustic stimuli, which predominantly analysed single tones and colours by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and acoustic stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical colour. The results show that multisensory features expressed by adjectives such as ‘quick’, ‘agitated’, and ‘strong’, and their antonyms ‘slow’, ‘calm’, and ‘weak’ characterized both the visual and acoustic stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness or to feelings of sadness and spatial orientation did not play a significant role in the association. The main result of the study consists in showing the existence of cross-modal associations between high complex stimuli.

  13. Hail to Thee, Our Alma Mater: Alumni Role Identity and the Relationship to Institutional Support Behaviors

    Science.gov (United States)

    McDearmon, J. Travis

    2013-01-01

    With the decline in state and federal support for higher education continuing to plague colleges and universities across the U.S., many institutions are looking to increase the levels of support annually received from alumni and other constituencies. Research on alumni relations in American colleges and universities has historically focused on…

  14. Mater Sapientia : de mystagogische functie van het moederschap van God en het geestelijke moederschap bij Augustinus

    NARCIS (Netherlands)

    Bouwman, C.H.M.

    2015-01-01

    In the theological works of the Christian of Church father Augustine (354-430) many references to motherhood can be found, as had been remarked often in passing. This study systematically explores these references in his texts and analyses the significance of these mother images from the perspective

  15. Light-Emitting Diodes: Phosphorescent Nanocluster Light-Emitting Diodes (Adv. Mater. 2/2016).

    Science.gov (United States)

    Kuttipillai, Padmanaban S; Zhao, Yimu; Traverse, Christopher J; Staples, Richard J; Levine, Benjamin G; Lunt, Richard R

    2016-01-13

    On page 320, R. R. Lunt and co-workers demonstrate electroluminescence from earth-abundant phosphorescent metal halide nanoclusters. These inorganic emitters, which exhibit rich photophysics combined with a high phosphorescence quantum yield, are employed in red and near-infrared light-emitting diodes, providing a new platform of phosphorescent emitters for low-cost and high-performance light-emission applications.

  16. Cervical cancer awareness and cervical screening uptake at the Mater Misericordiae Hospital, Afikpo, Southeast Nigeria.

    Science.gov (United States)

    Eze, Justus N; Umeora, Odidika U; Obuna, Johnson A; Egwuatu, Vincent E; Ejikeme, Brown N

    2012-01-01

    Cervical cancer is the most common genital tract malignancy among women in developing countries. To assess the awareness of cervical cancer among Igbo women in a rural population of Southeastern Nigerian and determine their uptake of cervical screening services. A questionnaire-based descriptive cross-sectional study. Structured questionnaires were administered to female attendees to the antenatal and gynecological clinics of a secondary hospital in the outskirts of Afikpo, Southeast Nigeria over a six-month period (1 st July to 31 st December 2007). Data analysis was by SPSS. Five hundred questionnaires were given out. Three hundred and sixty were correctly filled (72%) and analyzed. The mean age of respondents was 36.2 years, 25.0% had tertiary education and 40.3% were self employed. All the respondents were sexually active. There were high incidences of premarital sex, multiple sexual partners and abnormal vaginal discharge and low condom use. Awareness of cervical cancer (37.5%), its preventable nature (31.9%), cervical screening (25%) and screening centers (20.8%) were generally low and screening uptake (0.6%) was abysmally low. Lack of awareness, non-availability of screening centers locally, cost and time were the main reasons adduced by respondents for not being screened. Overall, 62.5% of all the respondents indicated willingness to be screened. The exposure to conditions that predispose women to cervical cancer was high, and the levels of awareness of cervical cancer and cervical screening uptake were low. Continued awareness creation, local provision of cheap and affordable services and poverty alleviation are needed to improve cervical screening uptake with the hope of reducing the incidence of cervical cancer in the long term.

  17. Hail to Thee, Our Alma Mater: Alumni Role Identity and the Relationship to Institutional Support Behaviors

    Science.gov (United States)

    McDearmon, J. Travis

    2013-01-01

    With the decline in state and federal support for higher education continuing to plague colleges and universities across the U.S., many institutions are looking to increase the levels of support annually received from alumni and other constituencies. Research on alumni relations in American colleges and universities has historically focused on…

  18. Talis mater, talis filia: las malas madres en los siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Amaia Nausia Pimoulier

    2013-12-01

    Full Text Available Este artículo presenta un tipo de violencia familiar protagonizado por madres e hijas navarras de los siglos XVI y XVII. Las acu-saciones por lenocinio o alcahuetería contra las madres que emplearon a sus propias hijas en sus tratos de mediadoras sirven para ilustrar una forma de violencia que supone, entre otras cosas, una ruptura del amor materno. La preca-ria situación de la madre y las dificultades tras el fallecimiento del esposo —la gran parte de los casos están protagonizados por madres viu-das— fue el contexto general en el que se desarrollaron los malos tratos. La historia de estas mujeres representa un mal ejercicio de la autoridad materna y una forma de violencia hacia las hijas; una violencia no siempre física, pero sí emocional y psicológica.

  19. Patterns of Giving to One's Alma Mater among Young Graduates from Selective Institutions.

    Science.gov (United States)

    Monks, James

    2003-01-01

    Examines individual characteristics correlated with alumni giving by graduates from 28 highly selective institutions of higher education. Finds satisfaction with undergraduate experience the single biggest determinant of the generosity of alumni donations. (Contains 11 references.) (PKP)

  20. Factors Associated with Non-Traditional and Traditional Undergraduate Alumni Giving to Alma Maters

    Science.gov (United States)

    Johnson, Elizabeth Ann Miller

    2013-01-01

    Both public and private institutions of higher education face revenue shortfalls. In order to close budget gaps, colleges and universities must identify new revenue sources. Historically alumni are large providers of voluntary support to higher education institutions, but the numbers of alumni contributing financially is decreasing. The purpose of…

  1. The Qur'an, Interpretation And The Ma~ter Of Gender

    Directory of Open Access Journals (Sweden)

    TALİP ÖZDEŞ

    2008-06-01

    Full Text Available Kur'an, AIIah tarafından Cebrail aracılığı ile Hz. Muhammed'e gönderilmiş, hiçbir değişikliğe uğramadan bizlere kadar intikal ettirilmiştir. Vahiylerin amacı, yeryüzünde yaşamakta olan insanlara Allah'ın varlık ve birliğini, hayatın anlam ve gayesini kavrama noktasında yardımcı olmak, onları doğru yola ve dine· .irşad etmektir. Kur'an'a göre Kur'an'ın ayetleri ile bilimsel- gerçekler arasında yakın bir ilişki vardır. Kur'an'da hem Kur'an'ın cümlelerine hem de olgulara/gerçeklere ayet ismi verilmektedir. Allah, kendi ayetlerine insanların dikkatini çekmekte ve onları gerçek hidayete ulaşmaları, Kur'an ayetlerinin, yaratıl­ışın, bilimsel gerçeklerin ve peygamberlerin mucizelerinin arkasındaki sınırsız gücü idrak etmeleri için derin bir şekilde düşünmeye davet etmektedir. Kur'an, Hz. Peygamber'e gönderilen Allah kelami olmasına rağmen, onun yorumu ve tefsiri insanlara aittir. Bundan dolayı, Kur'an metninin anlaşılıp yorumlanmasını subjektif kılan bazı faktörler vardır; yani Kur'an ve Kur'an'ın yorumu aynı şeyler değildir ve seviyeleri farklıdır. Örneğin, aynı ayet veya ayetler üzerinde yapılmış farklı yorumları bulabilir ve onlardan· birini doğru/sahih yorum olarak seçebiliriz. Dolayısı ile yorumu yanlış anlamalardan, spekülatif görüş ve değerlendirmelerden kurtarmak için Kur'an'a yaklaşımda tutarlı ve doğru bir metodumuzun olması gerekir. Cinsiyet konusunda da Kur'an'ın kendisi ile geleneklerin, adetlerin ve ataerkil zihniyetierin etkisi altında şekillenen birtakım yorumlar ve dini anlayışlar arasında farklılıklar söz konusudur. Çoğu defa cinsiyet ayrımı ile cinsiyet ayrımcılığı birbirine karıştırılmıştır. Halbuki onlar aynı şeyler değildir. İslam, erkekle kadın arasında aile ve toplumda gerçek olarak kendisini hissettiren doğal farklılıkları görmekte ve hayatın organizasyonu noktasında onları dikkate almaktadır. Ancak İslam, erkek ve kadın arasında bir cinsiyet ayrımcılığı yapmamaktadır. Kur'an ve Sünnet'e göre erkek ve kadın aynı özden/ruhtan yaratılmış olup her ikisi de Allah'ın ve hukukun önünde eşit bir konumdadırlar. Her ikisi de birbirlerinin üzerinde karşılıklı ve dengeli haklara sahip olup birbirlerine karşı sorumludurlar. üstünlük erkek veya kadın olmakla, belirli bir kabileye, millete veya ırka mensup olmakla değil, ancak takva ile mümkündür. İslam hiçbir şekilde zulmü, adaletsizliği, ahlaksızlığı ve insan hakları ihlallerini kabul etmez.

  2. Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction

    NARCIS (Netherlands)

    Nakagomi, Takayuki; Molnar, Zoltan; Nakano-Doi, Akiko; Taguchi, Akihiko; Saino, Orie; Kubo, Shuji; Clausen, Martijn; Yoshikawa, Hiroo; Nakagomi, Nami; Matsuyama, Tomohiro

    2011-01-01

    Increasing evidence shows that neural stem/ progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical neu

  3. Coming Home: "Hermanos Academicos" Reflect on Past and Present Realities as Professors at Their Alma Mater

    Science.gov (United States)

    Reddick, Richard J.; Saenz, Victor B.

    2012-01-01

    In this article, Richard J. (Rich) Reddick and Victor B. Saenz, two assistant professors of color, utilize scholarly personal narrative to reflect on their trajectory from undergraduates at a predominantly White institution--one prominently mired in a legacy of discrimination and exclusion toward people of color--to faculty members at that same…

  4. Corrigendum to ;Accelerated materials evaluation for nuclear applications.; [J. Nucl. Mater. 488 (2017) 46-62

    Science.gov (United States)

    Griffiths, M.; Walters, L.; Greenwood, L. R.; Garner, F. A.

    2017-08-01

    In this article, a typographical error appears in Table 1 for the thermal flux of the FFTF reactor. We would like to take the opportunity to add another reactor, BR2, to the list. The corrected table is provided in this corrigendum.

  5. Alternative Plasmonic Materials: Alternative Plasmonic Materials: Beyond Gold and Silver (Adv. Mater. 24/2013)

    DEFF Research Database (Denmark)

    Naik, Gururaj V.; Shalaev, Vladimir M.; Boltasseva, Alexandra

    2013-01-01

    Beyond Silver and Gold: Better material buildingblocks are essential in transforming the novel ideas of plasmonics and metamaterials into technologies of the future, as reviewed by Alexandra Boltasseva and co-workers on page 3264. Devices built from tailored materials offer improved performance...

  6. Carbon Nanotubes: Printed Carbon Nanotube Electronics and Sensor Systems (Adv. Mater. 22/2016).

    Science.gov (United States)

    Chen, Kevin; Gao, Wei; Emaminejad, Sam; Kiriya, Daisuke; Ota, Hiroki; Nyein, Hnin Yin Yin; Takei, Kuniharu; Javey, Ali

    2016-06-01

    Printed electronics and sensors enable new applications ranging from low-cost disposable analytical devices to large-area sensor networks. Recent progress in printed carbon nanotube electronics in terms of materials, processing, devices, and applications is discussed on page 4397 by A. Javey and co-workers. The research challenges and opportunities regarding the processing and system-level integration are also discussed for enabling of practical applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Bloqueio peridural sacral: avaliação da duração da analgesia com o uso associado de lidocaína, fentanil e clonidina Bloqueo peridural sacral: evaluación de la duración de la analgesia con el uso asociado de lidocaína, fentanil y clonidina Epidural caudal block: evaluation of length of analgesia with the association of lidocaine, fentanyl and clonidine

    Directory of Open Access Journals (Sweden)

    Carlos Alberto de Souza Martins

    2004-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A associação de diferentes substâncias aos anestésicos locais é feita com o objetivo de melhorar a qualidade do bloqueio e prolongar a duração da analgesia. O objetivo deste trabalho foi comparar a eficácia da associação de clonidina, clonidina e fentanil e do fentanil à lidocaína, no tempo de analgesia pós-operatória. MÉTODO: O estudo envolveu 64 pacientes com idade igual ou superior a 23 anos, estado físico I ou II (ASA, escalados para cirurgia proctológica orificial, submetidos à anestesia peridural sacral. Os pacientes foram distribuídos em 4 grupos de 16: grupo I (lidocaína isolada, grupo II (lidocaína e fentanil, grupo III (lidocaína, fentanil e clonidina e grupo IV (lidocaína e clonidina. Foram comparadas as características dos bloqueios sensitivo e motor. RESULTADOS: Não houve diferença entre a latência, bem como no nível máximo de bloqueio entre os grupos. A ausência de bloqueio motor foi o resultado mais freqüente, encontrado em cerca de 64% dos pacientes. O intervalo de analgesia foi diferente entre os grupos, sendo mais significativo no grupo III. CONCLUSÕES: O uso da clonidina, associada ou não ao fentanil, prolongou o tempo de analgesia pós-operatória na anestesia peridural sacral com lidocaína.JUSTIFICATIVA Y OBJETIVOS: La asociación de diferentes substancias a los anestésicos locales es hecha con el objetivo de mejorar la cualidad del bloqueo y prolongar la duración de la analgesia. El objetivo de este trabajo fue comparar la eficacia de la asociación de clonidina, clonidina y fentanil y de fentanil a la lidocaína, en el tiempo de analgesia pós-operatoria. MÉTODO: El estudio envolvió 64 pacientes con edad igual o superior a 23 años, estado físico I ó II (ASA, escalados para cirugía proctológica orificial, sometidos a anestesia peridural sacral. Los pacientes fueron distribuidos en 4 grupos de 16: grupo I (lidocaína aislada, grupo II (lidocaína y

  8. Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice.

    Science.gov (United States)

    Chinnery, Holly R; Ruitenberg, Marc J; McMenamin, Paul G

    2010-09-01

    The mouse dura mater, pia mater, and choroid plexus contain resident macrophages and dendritic cells (DCs). These cells participate in immune surveillance, phagocytosis of cellular debris, uptake of antigens from the surrounding cerebrospinal fluid and immune regulation in many pathologic processes. We used Cx3cr1 knock-in, CD11c-eYFP transgenic and bone marrow chimeric mice to characterize the phenotype, density and replenishment rate of monocyte-derived cells in the meninges and choroid plexus and to assess the role of the chemokine receptor CX3CR1 on their number and tissue distribution. Iba-1 major histocompatibility complex (MHC) Class II CD169 CD68 macrophages and CD11c putative DCs were identified in meningeal and choroid plexus whole mounts. Comparison of homozygous and heterozygous Cx3cr1 mice did not reveal CX3CR1-dependancy on density, distribution or phenotype of monocyte-derived cells. In turnover studies, wild type lethally irradiated mice were reconstituted with Cx3cr1/-positive bone marrow and were analyzed at 3 days, 1, 2, 4 and 8 weeks after transplantation. There was a rapid replenishment of CX3CR1-positive cells in the dura mater (at 4 weeks) and the choroid plexus was fully reconstituted by 8 weeks. These data provide the foundation for future studies on the role of resident macrophages and DCs in conditions such as meningitis, autoimmune inflammatory disease and in therapies involving irradiation and hematopoietic or stem cell transplantation.

  9. A New Absorbable Synthetic Substitute With Biomimetic Design for Dural Tissue Repair.

    Science.gov (United States)

    Shi, Zhidong; Xu, Tao; Yuan, Yuyu; Deng, Kunxue; Liu, Man; Ke, Yiquan; Luo, Chengyi; Yuan, Tun; Ayyad, Ali

    2016-04-01

    Dural repair products are evolving from animal tissue-derived materials to synthetic materials as well as from inert to absorbable features; most of them lack functional and structural characteristics compared with the natural dura mater. In the present study, we evaluated the properties and tissue repair performance of a new dural repair product with biomimetic design. The biomimetic patch exhibits unique three-dimensional nonwoven microfiber structure with good mechanical strength and biocompatibility. The animal study showed that the biomimetic patch and commercially synthetic material group presented new subdural regeneration at 90 days, with low level inflammatory response and minimal to no adhesion formation detected at each stage. In the biological material group, no new subdural regeneration was observed and severe adhesion between the implant and the cortex occurred at each stage. In clinical case study, there was no cerebrospinal fluid leakage, and all the postoperation observations were normal. The biomimetic structure and proper rate of degradation of the new absorbable dura substitute can guide the meaningful reconstruction of the dura mater, which may provide a novel approach for dural defect repair.

  10. DURA-Peel, DURACON-Based Removable High Accuracy IR Thermography Coatings Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Fiber reinforced composite materials are used extensively in aerospace applications due to their high stiffness and strength to weight ratio, and superior thermal,...

  11. El Salvador’s crime prevention policies—from Mano Dura to El Salvador Seguro

    OpenAIRE

    Carballo, Carlos A.

    2015-01-01

    Approved for public release; distribution is unlimited This thesis examines Salvadoran policies that addressed the rise in violent crime by gangs. These gangs have posed the biggest security risk to El Salvador since the end of the civil war in 1992. The two biggest gangs are the Mara Salvatrucha (MS-13) and 18th Street, both originating in Los Angeles, CA, and which have proliferated throughout the Americas since the 1990s. Salvadoran administrations have tried to solve the issue in diffe...

  12. Capitalism's leading lady / Daiga Auzina-Melalksne ; interviewed by Raquel Dura Lahoz

    Index Scriptorium Estoniae

    Auzina-Melalksne, Daiga

    2010-01-01

    Riia börsi ja Ameerika Kaubanduskoja Lätis juht räägib börsi tähtsusest Läti majanduse jaoks, koostööst Tallinna ja Vilniuse börsidega, riigiettevõtete erastamisest, NASDAQ OMX Riga edaspidistest eesmärkidest ja leiab, et Baltimaad on väga atraktiivsed välisinvestorite jaoks

  13. El Salvador’s Crime Prevention Policies - From Mano Dura to El Salvador Seguro

    Science.gov (United States)

    2015-12-01

    Partnership for Growth PNC Policía Nacional Civil (National Police Force) UAC Unaccompanied Children UNODC United Nations Office on Drugs and Crime...alongside Cuban refugees instead of Los Angeles with the other Central American immigrants. Nicaragua avoided the after- effect of deported gang members and... Unaccompanied Children estimates that more than 50,000 unaccompanied minors were detained at the U.S. southern border in 2014.The research question

  14. Uma crise de longa duração A long-lasting crisis

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Nogueira

    2009-01-01

    Full Text Available O artigo procurar explorar a ideia de que no Brasil dos dias atuais vive-se numa situação de mal-estar institucional e crise política fortemente concentrada no plano da subjetividade política, ou seja, dos atores, ideias e projetos de sociedade. Busca discutir a recente crise do Senado como expressão dessa situação, vendo-a também como reflexo de um quadro mais amplo, que afeta os Parlamentos modernos de modo geral e poderia ser explicado como derivando de um cerco que o decisionismo governamental e as pressões sociais fazem sobre o Poder Legislativo, fazendo que perca eixo e capacidade de ação. Repercutindo os traços dominantes da época atual, os sistemas políticos e, por extensão, os Parlamentos tornam-se menos capazes de interagir de modo virtuoso com a cultura e as estruturas sociais derivadas dos novos termos da vida globalizada, ou seja, com sociedades plurais, fragmentadas, reflexivas, velozes e explosivas.This paper aims to explore the idea that we are currently facing a situation of institutional unrest and political crisis strongly concentrated on political subjectivity, that is, on players, ideas and projects of society. It attempts to discuss the recent crisis in Brazil's Senate as an expression of this situation, but also as a reflection of a wider framework, which affects modern Parliaments in general and could be seen as resultant from a siege laid by government decisionism and social pressures to the Legislative branch, depriving it from its axis and capacity to act. Echoing the dominant features of the present time, political systems and, by inference, Parliaments are rendered less able to interact in a virtuous way with culture and social structures that derive from the new terms of globalized life, that is, with plural, fragmented, reflexive, quick and explosive societies.

  15. Para un corpus de las piedras duras en España. Algunas precisiones

    Directory of Open Access Journals (Sweden)

    Aguiló Alonso, María Paz

    2002-09-01

    Full Text Available Through the presentation of an unpublished Roman piètre dure table preserved in the Abadía del Sacromonte (Granada, the possible provenances of other similar tables are revised, as is the art trade in these objects and their utilization as diplomatic gifts during the late sixteenth century.

    A través de la publicación de una mesa romana inédita, conservada en la granadina Abadía del Sacromonte, se revisan las posibles procedencias de otros tableros así como las vicisitudes del tráfico artístico de estos objetos y su utilización como regalo diplomático a finales del siglo XVI.

  16. Capitalism's leading lady / Daiga Auzina-Melalksne ; interviewed by Raquel Dura Lahoz

    Index Scriptorium Estoniae

    Auzina-Melalksne, Daiga

    2010-01-01

    Riia börsi ja Ameerika Kaubanduskoja Lätis juht räägib börsi tähtsusest Läti majanduse jaoks, koostööst Tallinna ja Vilniuse börsidega, riigiettevõtete erastamisest, NASDAQ OMX Riga edaspidistest eesmärkidest ja leiab, et Baltimaad on väga atraktiivsed välisinvestorite jaoks

  17. O custo salarial da duração do desemprego para o trabalhador

    Directory of Open Access Journals (Sweden)

    Paulo Aguiar do Monte

    2009-12-01

    Full Text Available This paper analyzes the influence of unemployment on occupational reinsertion, specifically on the wage earned by the workers who transitioned from unemployment to being employed. Using sample data from Monthly Employment Survey (PME, 2000, from Brazil, and quantile regression techniques, this study provides evidence about the relationship between duration of unemployment and wage loss. The results show a heterogeneous chance to remain unemployed, in favor, mainly, of less qualified workers, and, in addition, wage losses are observed when the employed find a new job (occupational reinsertion. Moreover, in general, workers who have more qualification are more penalized, regardless of the quantile conditional wage distribution they are in, indicating a greater loss for employees in jobs that require higher qualification.

  18. Baltic States and Poland will work together on energy issues / Raquel Dura Lahoz

    Index Scriptorium Estoniae

    Dura Lahoz, Raquel

    2010-01-01

    Riias 10.-11. septembril 2010. a. toimunud välis- ja julgeolekupoliitika konverentsist, kus osales ka president Toomas Hendrik Ilves. Konverentsil rääkisid Baltimaade ja Poola presidendid energiaalasest koostööst ning leidsid, et Euroopa Liit vajab ühtset poliitikat Venemaa suhtes

  19. Role of KATP channels in the regulation of rat dura and pia artery diameter

    DEFF Research Database (Denmark)

    Gozalov, A.; Petersen, K.A.; Mortensen, C.;

    2005-01-01

    The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced ...

  20. Traumatic brain injury with a machete penetrating the dura and brain: Case report from southeast Mexico

    Directory of Open Access Journals (Sweden)

    Juan D. Del Castillo-Calcáneo

    2016-01-01

    Conclusion: The use of current algorithms for managing NMP cranial trauma has proved to be very useful when applied on this particular case. GCS on admission is an important prognostic factor in NMP cranial trauma.

  1. Baltic States and Poland will work together on energy issues / Raquel Dura Lahoz

    Index Scriptorium Estoniae

    Dura Lahoz, Raquel

    2010-01-01

    Riias 10.-11. septembril 2010. a. toimunud välis- ja julgeolekupoliitika konverentsist, kus osales ka president Toomas Hendrik Ilves. Konverentsil rääkisid Baltimaade ja Poola presidendid energiaalasest koostööst ning leidsid, et Euroopa Liit vajab ühtset poliitikat Venemaa suhtes

  2. La inevitable "mano dura": sociedad civil y violencia policial en Argentina y Chile

    Directory of Open Access Journals (Sweden)

    Claudio Fuentes S.

    2004-01-01

    Full Text Available Si bien todas las sociedades democráticas modernas aceptan en teoría la inviolabilidad de la integridad física de los ciudadanos como parte integrante de sus constituciones, existe una constante tensión entre la protección de este derecho y el uso de la fuerza por parte de los aparatos de seguridad para prevenir el crimen y la delincuencia. Este artículo estudia la dimensión política de este conflicto, analizando el rol que cumple la sociedad civil en la protección de los derechos de las personas. Se argumenta que son tres los factores importantes de visualizar: el acceso al sistema político, los recursos para la movilización de que se dispone, y el nivel de corporativismo de la policía. Considerando el caso de Argentina, se investiga la influencia de la tercera dimensión -nivel de corporativismo- contrastando a la Policía Federal de la Capital de Buenos Aires, la policía de la Provincia de Buenos Aires y el caso de Carabineros de Chile. Se concluye que la sociedad civil organizada tiene un impacto mucho más importante en la definición de la agenda política que en la implementación de políticas incluso en casos donde dichos grupos de la sociedad civil son fuertes. Asimismo, los factores institucionales cumplen un rol importante en la definición de cuándo y dónde es más probable influir para que una reforma de la policía sea posible.Even though modern democratic societies accept the inviolability of individuals' physical integrity as an essential part of their Constitutions, there is a difficult trade off between the protection of citizens' rights and the use of force to protect public safety. This article explores the political dimension of this tension, analyzing the role played by organized civil society in protecting citizens` rights. In this article, I argue that three factors are crucial to understand such influence: the access to the political system, the resources for mobilization these groups have, and the level of police corporativeness. Considering the case of Argentina, the article analyzes the impact of the third dimension -police corporativeness- contrasting the cases of the Federal Police in the Buenos Aires Capital District, the Provincial Police in the surrounding area of Buenos Aires, and the case of Carabineros in Chile. The main claim of this article is that organized civil society has an greater impact over agenda setting than over policy implementation even in cases where civil society is strong. Moreover, institutional factors play a crucial role in solving the question of when and where the influence of civil society is more likely.

  3. Tempo de latência e duração do efeito do rocurônio, atracúrio e mivacúrio em pacientes pediátricos Tiempo de latencia y duración del efecto del rocuronio, atracúrio y mivacúrio en pacientes pediátricos Onset time and duration of rocuronium, atracurium and mivacurium in pediatric patients

    Directory of Open Access Journals (Sweden)

    Norma Sueli Pinheiro Módolo

    2002-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os bloqueadores neuromusculares (BNM são freqüentemente utilizados em anestesia pediátrica e não existe aquele considerado ideal. O objetivo deste trabalho foi avaliar o rocurônio, o atracúrio e o mivacúrio, em crianças, quanto ao tempo de latência e de recuperação, à interferência sobre as variáveis hemodinâmicas e às condições de intubação traqueal. MÉTODO: Sessenta e sete crianças, estado físico ASA I e II, com idade variando de 2 anos e 6 meses a 12 anos, foram anestesiadas com alfentanil (50 µg.kg-1, propofol (3 mg.kg-1, sevoflurano e N2O/O2 e divididas em três grupos: G1 = rocurônio 0,9 mg.kg-1 (n = 22; G2 = atracúrio 0,5 mg.kg-1 (n = 22 e G3 = mivacúrio 0,15 mg.kg-1 (n = 23. A monitorização do bloqueio neuromuscular foi realizada com o método de aceleromiografia no trajeto do nervo ulnar. Foram estudados: o tempo de latência (TL, a duração clínica (T25, o tempo de relaxamento (T75 e o índice de recuperação (T25-75. A pressão arterial média (PAM e a freqüência cardíaca (FC foram registradas em seis momentos, bem como as condições encontradas no momento da intubação traqueal. RESULTADOS: A mediana do TL foi de 0,6 minutos em G1, 1,3 minutos em G2 e 1,9 minutos em G3. A mediana do T25 foi em G1 = 38 minutos, G2 = 41,5 minutos e G3 = 8,8 minutos. A mediana do T75 foi em G1 = 57,7 minutos, G2 = 54,6 minutos e G3 = 13,6 minutos. A mediana do índice de recuperação (T25-75 foi em G1 = 19,7 minutos, G2 = 13,1 minutos e G3 = 4,8 minutos. As condições de intubação traqueal foram consideradas excelentes na maioria dos pacientes de ambos os grupos. Não houve modificações clínicas importantes da PAM e da FC. CONCLUSÕES: O rocurônio, 0,9 mg.kg-1, teve o menor tempo de latência e o mivacúrio, 0,15 mg.kg-1, o menor tempo de recuperação nos pacientes pediátricos anestesiados com sevoflurano. Também, o rocurônio, o mivacúrio e o atracúrio não determinaram altera

  4. Definition of the to be named ligament and vertebrodural ligament and their possible effects on the circulation of CSF.

    Directory of Open Access Journals (Sweden)

    Nan Zheng

    Full Text Available Few studies have been conducted specifically on the dense connective tissue located in the posterior medial part of the cervical epidural space. This study was undertaken to examine the presence of this connection between the cervical dura mater and the posterior wall of spinal canal at the level of C1-C2. 30 head-neck specimens of Chinese adults were used. Gross dissection was performed on the suboccipital regions of the 20 specimens. Having been treated with the P45 plastination method, 10 specimens were sliced (9 sagittal and 1 horizontal sections. As a result, a dense fibrous band was identified in the nuchal ligament of 29 specimens (except for one horizontal section case. This fascial structure arose from the tissue of the posterior border of the nuchal ligament and then projected anteriorly and superiorly to enter the atlantoaxial interspace. It was termed as to be named ligament (TBNL. In all 30 specimens the existence of a fibrous connection was found between the posterior aspect of the cervical dura mater and the posterior wall of the spinal canal at the level of the atlas to the axis. This fibrous connection was identified as vertebrodural ligament (VDL. The VDL was mainly subdivided into three parts, and five variations of VDL were identified. These two structures, TBNL and VDL, firmly link the posterior aspect of cervical dura mater to the rear of the atlas-axis and the nuchal region. According to these findings, the authors speculated that the movements of the head and neck are likely to affect the shape of the cervical dural sleeve via the TBNL and VDL. It is hypothesized that the muscles directly associated with the cervical dural sleeve, in the suboccipital region, may work as a pump providing an important force required to move the CSF in the spinal canal.

  5. Genetic Mapping in Papillon-Lefèvre Syndrome: A Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Kaustubh Suresh Thakare

    2013-01-01

    Full Text Available Papillon-Lefevre syndrome (PLS is a rare autosomal recessive heterogeneous trait which is characterized by erythematous palmoplantar hyperkeratosis, early-onset periodontitis, and associated calcification of dura mater. The etiology of PLS is multifactorial with genetic, immunological, and microbial factors playing a role in etiopathogenesis. Recently identified genetic defect in PLS has been mapped to chromosome 11q14–q21, which involves mutations of cathepsin C. This paper presents a report of 2 cases of Papillon-lefevre syndrome in which diagnosis is based on clinical presentation and genetic mapping.

  6. Central projections of the sensory innervation of the rat middle meningeal artery

    DEFF Research Database (Denmark)

    Liu, Y.; Broman, J.; Edvinsson, L.

    2008-01-01

    the central projections of sensory nerves that innervate cranial vessels, of which the middle meningeal artery (MMA) is the largest artery supplying the dura mater. In this study, cholera toxin subunit b (CTb) or wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) was applied on the adventitia...... in laminae III-V. These results indicate that sensory information from the MMA is transmitted through both trigeminal and cervical spinal nerve branches to a region in the central nervous system extending rostrally from the C3 dorsal horn to the interpolar part of the spinal trigeminal nucleus. Our data...

  7. Prostaglandin E2 receptor expression in the rat trigeminal-vascular system and other brain structures involved in pain

    DEFF Research Database (Denmark)

    Myren, Maja; Olesen, Jes; Gupta, Saurabh

    2012-01-01

    receptors in both peripheral and central structures involved in pain transmission and perception in migraine: dura mater, cerebral arteries, trigeminal ganglion, trigeminal nucleus caudalis, periaqueductal grey, thalamus, hypothalamus, cortex, pituitary gland, hippocampus and cerebellum. In the trigeminal...... than in dorsal root ganglia (peripheral control), whereas the EP(2) mRNA and protein were highly abundant in the pituitary gland. EP(3) mRNA was mainly found in thalamus and hypothalamus. The most robust mRNA and protein expression for EP(4) receptor was seen in the dorsal root ganglion. In conclusion...

  8. Penetrating injury of orbital roof and brain sparing the eye ball in a pediatric patient: A rare occurrence.

    Science.gov (United States)

    Kumar, Vikul; Singh, Atul Kumar; Bhaikhel, Kulwant Singh

    2016-01-01

    Blowout fractures are a common occurrence in traumatic brain injury patients. In pediatric age group, orbital floor fracture is a common occurrence. We report a case of 2-year-old male admitted to trauma center, with penetrating injury to the left eye by the clutch of motorbike which fell on the child. Noncontrast computed tomography scan revealed fracture of the roof of left orbit with left frontal contusion sparing the left eyeball. There was also the continuous leak of brain matter from the left eye which suggested tear of dura mater. Urgent left frontal craniotomy was done with the evacuation of contusion, reconstruction of orbital roof, and duroplasty under general anesthesia.

  9. Spontaneous intracranial hypotension syndrome: magnetic resonance findings in two patients; Sindrome de hipotension intracraneal espontanea: hallazgos en resonancia magnetica en dos pacientes

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, R.; Pastor, J.; Escamilla, F.; Romero, M. I. [Hospital de Traumatologia y Reabilitacion. Granada (Spain)

    1999-07-01

    The postural headache syndrome associated with a decrease in the cerebrospinal fluid (CSF) pressure is generally secondary to the CSF leakage that usually occurs after diagnostic lumbar puncture. Spontaneous intracranial hypotension can not be attributed to any known cause or previous diagnostic or therapeutic intervention. The syndrome is characterized by severe headache that is relieved by lying supine. During lumbar puncture, the CSF pressure is normally low. We present two patients in whom gadolinium-enhanced magnetic resonance imaging showed widespread thickening and enhancement of the dura mater and subdural fluid collections. (Author) 13 refs.

  10. Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage

    DEFF Research Database (Denmark)

    Lundblad, Cornelia; Haanes, Kristian A; Grände, Gustaf

    2015-01-01

    , following dural application of complete Freund's adjuvant (CFA) or inflammatory soup (IS) on brain and trigeminal microvascular passage. METHODS: In order to address this issue, we induced local inflammation in male Sprague-Dawley-rats dura mater by the addition of CFA or IS directly on the dural surface......) in a major way. However, [(51)Cr]-EDTA readily passed the TG by >30 times compared to the CNS. Application of CFA or IS did not show altered transfer constants. CONCLUSIONS: With these experiments we show that dural IS/CFA triggered TG inflammation, did not increase the BBB passage, and that the TG...

  11. Post-traumatic cerebrospinal fluid fistula: a case report; Fistula liquorica pos-traumatica - relato de um caso

    Energy Technology Data Exchange (ETDEWEB)

    Tamburus, Wander Miguel; Figueiredo Wanderley, Eliana Christina; Maciel, Damacio Ramon Kaimen; Narciso, Avelino Jose Soares; Sendenski, Mauricio Michalak [Universidade Estadual de Londrina, PR (Brazil). Centro de Ciencias da Saude

    1996-10-01

    Fronto-basal fracture occurs in around 5% of cranioencephalic trauma. the involved structures are: arachnoid, dura-mater, osseous base and the mucosa, and there us contact between the brain and the environment. Even with rupture of all these structures cerebrospinal fluid leakage may not occur; regardless of this, there may be infectious complications, such as bacterial meningitis or brain abscess. the authors report the case of a patient with head injury and four bacterial meningitis, the diagnosis of post-traumatic liquoric fistula being made only through magnetic resonance imaging. (author) 10 refs., 1 fig.

  12. Neuronal Fibers and Neurotransmitter Receptor Expression in the Human Endolymphatic Sac

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Kirkeby, Svend; Vikeså, Jonas

    2017-01-01

    in intracranial pressure homeostasis. The anatomical location towards the sigmoid sinus would suggest a possible endo- and/or paracrine signaling. However, neuronal connections may also apply, but it remains very scarcely explored in the human ES. STUDY DESIGN: DNA micro-arrays and immunohistochemistry were used...... for analyses of fresh human ES tissue samples. METHODS: A total of 30 tissue samples from the human ES were obtained during translabyrinthine surgery for vestibular schwannoma. Microarray technology was used to investigate tissue sample gene expression, using adjacent dura mater as control. The expression...

  13. 人工膜を用いて胸壁再建を行った小児胸壁原発腫瘍の2例

    OpenAIRE

    村松, 俊範; 高橋,英世; 大沼, 直躬; 田辺,政裕; 吉田,英生; 岩井, 潤; ムラマツ, トシノリ; タカハシ,ヒデヨ; オオヌマ, ナオミ; タナベ, マサヒロ; ヨシダ, ヒデオ; イワイ, ジュン; MURAMATSU, Toshinori; Takahashi, Hideyo; OHNUMA, Naomi

    1991-01-01

    Reconstruction of chest wall defect after surgery is necessary to prevent the flail chest. We report herein two cases of chest wall tumor repaired with prosthetic materials. A two-year-old boy had left chest wall tumor resected with the 8th, 9th and 10th ribs (Case 1). The 4×8cm defect was covered with Dura mater (Lyodura). Pathological diagnosis of this tumor was eosinophilic granuloma. Another case was a three-month-old boy. He had left chest wall tumor, (Case 2). As tumor size was very hug...

  14. Posterior atlanto-occipital and atlanto-axial area and its surgical interest

    Directory of Open Access Journals (Sweden)

    Newton José Godoy Pimenta

    2014-10-01

    Full Text Available Classic anatomical studies describe two membranes – atlanto-occipital and atlanto-axial in the posterior aspect of the craniocervical region. During many surgical procedures in this area, however, we have not found such membranes. Objective To clarify the anatomical aspects and structures taking part of the posterior atlanto-occipital and atlanto-axial area. Method Analysis of histological cuts of three human fetuses and anatomical studies of 8 adult human cadavers. Results In both atlanto-occipital and atlanto-axial areas, we have observed attachment between suboccipital deep muscles and the spinal cervical dura. However, anatomical description of such attachments could not be found in textbooks of anatomy. Conclusion Our study shows the absence of the classical atlanto-occipital and atlanto-axial membranes; the occipito-C1 and C1-C2 posterior intervals are an open area, allowing aponeurotic attachment among cervical dura mater and posterior cervical muscles.

  15. Case of Langerhans Cell Histiocytosis That Mimics Meningioma in CT and MRI

    Science.gov (United States)

    Zhu, Ming; Yu, Bing-Bing; Zhai, Ji-Liang

    2016-01-01

    Langerhans cell histiocytosis (LCH) is a rare disorder histologically characterized by the proliferation of Langerhans cells. Here we present the case of a 13-year-old girl with LCH wherein CT and MRI results led us to an initially incorrect diagnosis of meningioma. The diagnosis was corrected to LCH based on pathology findings. An intracranial mass was found mainly in the dura mater, with thickening of the surrounding dura. It appeared to be growing downward from the calvaria, pressing on underlying brain tissue, and had infiltrated the inner skull, causing a bone defect. The lesion was calcified with the typical dural tail sign. The dural origin of the lesion was verified upon surgical dissection. There are no previous reports in the literature describing LCH of dural origin presenting in young patients with typical dural tail signs and meningioma-like imaging findings. The current case report underscores the need for thorough histological and immunocytochemical examinations in LCH differential diagnosis. PMID:26962425

  16. Estudo micro-mesoscópico da parede lateral do seio cavernoso humano Human cavernous sinus: micro-mesoscopic study of the lateral wall

    Directory of Open Access Journals (Sweden)

    Renato Paulo Chopard

    1996-12-01

    Full Text Available Os autores estudam as estruturas contidas no seio cavernoso humano, tanto em seu interior como na sua parede lateral, através de cortes frontais seriados espessos. Mostram a importância desta parede que é freqüentemente usada como via de acesso cirúrgico às afecções presentes nesta estrutura venosa da dura-máterThe authors studied the structures of human cavernous sinus in its interior as well as on the lateral wall, utilizing thick, frontal, sequential sections. They show the significance of this wall, frequently used as surgical accessway to diseases encountered within this venous structure of the dura-mater.

  17. Delamination technique together with longitudinal incisions for treatment of Chiari I/syringomyelia complex: a prospective clinical study

    Directory of Open Access Journals (Sweden)

    Savas Yildiray

    2009-06-01

    Full Text Available Abstract Background Treatment modalities in Chiari malformation type 1(CMI accompanied by syringomyelia have not yet been standardized. Pathologies such as a small posterior fossa and thickened dura mater have been discussed previously. Various techniques have been explored to enlarge the foramen magnum and to expand the dura. The aim of this clinical study was to explore a new technique of excision of the external dura accompanied by widening the cisterna magna and making longitudinal incisions in the internal dura, without disturbing the arachnoid. Methods Ten patients with CMI and syringomyelia, operated between 2004 and 2006, formed this prospective series. All cases underwent foramen magnum decompression of 3 × 3 cm area with C1–C2 (partial laminectomy, resection of foramen magnum fibrous band, excision of external dura, delamination and widening of internal dura with longitudinal incisions. Results Patients were aged between 25 and 58 years and occipital headache was the most common complaint. The mean duration of preoperative symptoms was 4 years and the follow-up time was 25 months. Clinical progression was halted for all patients; eight patients completely recovered and two reported no change. In one patient, there was a transient cerebrospinal fluid (CSF fistula that was treated with tissue adhesive. While syringomyelia persisted radiologically with radiological stability in five patients; for three patients the syringomyelic cavity decreased in size, and for the remaining two it regressed completely. Conclusion Removal of the fibrous band and the outer dural layer, at level of foramen magnum, together with the incision of inner dural layer appears to be good technique in adult CMI patients. The advantages are short operation time, no need for duraplasty, sufficient posterior fossa decompression, absence of CSF fistulas as a result of extra arachnoidal surgery, and short duration of hospitalization. Hence this surgical technique has

  18. Morphology of the walls of the cavernous sinus of Cebus apella (tufted capuchin monkey Morfologia das paredes do seio cavernoso em Cebus apella (macaco-prego

    Directory of Open Access Journals (Sweden)

    ROBSON JOSÉ DE SOUSA DOMINGUES

    1999-09-01

    Full Text Available The morphology of the dura mater and its relationship with the structures of the cavernous sinus were analyzed in five tufted capuchin monkeys (Cebus apella using histological sections, showing that the walls of the cavernous sinus of this species are similar to those of other primates, including man. Except for the medial wall of the cavernous sinus, the remaining walls consist of two distinct dura mater layers. The deep layer of the lateral wall of the cavernous sinus is contiguous to the sheath of the oculomotor, trochlear and ophthalmic nerves. Arterioles, venules, venous spaces, neuronal bodies and nervous fiber bundles are found on this lateral wall.A morfologia da dura-máter e sua relação com as estruturas do seio cavernoso, analisadas em cinco macacos-prego (Cebus apella através de cortes histológicos, mostrou que as paredes do seio cavernoso nessa espécie são semelhantes a de outros primatas, inclusive o homem. Com exceção da parede medial do seio cavernoso as demais paredes são formadas de duas camadas distintas de dura-máter. A camada profunda da parede lateral do seio cavernoso está em continuidade com a bainha dos nervos oculomotor, troclear e oftálmico. Nesta parede lateral são encontradas arteríolas, vênulas, espaços venosos, corpos de neurônios e feixes de fibras nervosas.

  19. Embryological Consideration of Dural Arteriovenous Fistulas

    Science.gov (United States)

    TANAKA, Michihiro

    2016-01-01

    The topographical distribution of dural arteriovenous fistulas (DAVFs) was analyzed based on the embryological anatomy of the dural membrane. Sixty-six consecutive cases of intracranial and spinal DAVFs were analyzed based on the angiography, and each shunt point was identified according to the embryological bony structures. The area of dural membranes was categorized into three different groups: a ventral group located on the endochondral bone (VE group), a dorsal group located on the membranous bone (DM group) and a falcotentorial group (FT group) located in the falx cerebri, tentorium cerebelli, falx cerebelli, and diaphragm sellae. The FT group was designated when the dural membrane was formed only with the dura propria (meningeal layer of the dura mater) and not from the endosteal dura. Cavernous sinus, sigmoid sinus, and anterior condylar confluence was categorized to VE group, which had a female predominance, more benign clinical presentations, and a lower rate of cortical and spinal venous reflux. Transverse sinus, confluence, and superior sagittal sinus belonged to the DM group. Olfactory groove, falx, tent of the cerebellum, and nerve sleeve of spinal cord were categorized to the FT group, which presented later in life and which had a male predominance, more aggressive clinical presentations, and significant cortical and spinal venous reflux. The DAVFs was associated with the layers of the dural membrane characterized by the two different embryological bony structures. The FT group was formed only with the dura propria as an independent risk factor for aggressive clinical course and hemorrhage of DAVFs. PMID:27250699

  20. Perovskite Solar Cells: High Efficiency Pb-In Binary Metal Perovskite Solar Cells (Adv. Mater. 31/2016).

    Science.gov (United States)

    Wang, Zhao-Kui; Li, Meng; Yang, Ying-Guo; Hu, Yun; Ma, Heng; Gao, Xing-Yu; Liao, Liang-Sheng

    2016-08-01

    On page 6695, X. Y. Gao, L.-S. Liao, and co-workers describe the fabrication of mixed Pb-In perovskite solar cells, using indium (III) chloride and lead (II) chloride with methylammonium iodide. A maximum power conversion efficiency as high as 17.55% is achieved owing to the high quality of the perovskites with multiple ordered crystal orientations. This work demonstrates the possibility of substituting the Pb (II) by using In (III), which opens a broad route to fabricating alloy perovskite solar cells with mitigated ecological impact. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Corrigendum to "Thermophysical properties of U3Si2 to 1773 K" [J. Nucl. Mater. 464 (2015) 275-280

    Science.gov (United States)

    White, J. T.; Nelson, A. T.; Dunwoody, J. T.; Safarik, D. J.; McClellan, K. J.

    2017-02-01

    An error was discovered by the authors in the calculation of thermal diffusivity in "Thermophysical properties of U3Si2 to 1773 K" [1]. The error was caused by operator error in entry of parameters used to fit the temperature rise versus time model necessary to calculate the thermal diffusivity. This error propagated to the calculation of thermal conductivity, leading to values that were 18%-28% larger along with the corresponding calculated Lorenz values. This error affects Figs. 5 and 6, Eqn. (4), and Table A.1 of the text. The corrected Figs. 5 and 6 are shown below along with the updated residual squares analysis of thermal conductivity versus temperature in Eqn. (4) and tabulated thermophysical property values in Table A.1. The residual sum of squares, R2, for Eqn. (4) did not change with the updated thermal conductivity values. Thermal conductivity values in Fig. 6 are in better accord with Shimizu's arc-cast data [2] and the calculated Lorentz values, shown in the inset of Fig. 6, are in better agreement with the expected Lorentz value.

  2. Nanowires: Quantitative Probing of Cu(2+) Ions Naturally Present in Single Living Cells (Adv. Mater. 21/2016).

    Science.gov (United States)

    Lee, Junho; Lee, Hwa-Rim; Pyo, Jaeyeon; Jung, Youngseob; Seo, Ji-Young; Ryu, Hye Guk; Kim, Kyong-Tai; Je, Jung Ho

    2016-06-01

    Quantitative probing of the Cu(2+) ions naturally present in single living cells is accomplished by a probe made from a quantum-dot-embedded-nanowire waveguide. After inserting the active nanowire-based waveguide probe into single living cells, J. H. Je and co-workers directly observe photoluminescence (PL) quenching of the embedded quantum dots by the Cu(2+) ions diffused into the probe as described on page 4071. This results in quantitative measurement of intracellular Cu(2+) ions.

  3. DESINGN AND EVALUATION OF A RAIL MADE OF CARBON FIBER REINFORCED MATERAL FOR AN EXTERNAL FIXATION SYSTEM

    Directory of Open Access Journals (Sweden)

    FABIAN ORTEGA

    2012-01-01

    Full Text Available Este articulo muestra el diseño, construcción y evaluación de un riel para un sistema de fijación externa utilizado para transporte óseo. El riel fue hecho con material compuesto CF/EP (fibra de carbono/ resina epoxica. Un proceso manual simple fue utilizado para la construcción del elemento; posteriormente, el riel fue evaluado por medio de pruebas mecánicas bajo carga axial, flexión y torsión. La rigidez del nuevo elemento fue comparada con la rigidez de un riel comercial y se obtuvieron buenos resultados.

  4. 3D Printing: 3D Printing of Shape Memory Polymers for Flexible Electronic Devices (Adv. Mater. 22/2016).

    Science.gov (United States)

    Zarek, Matt; Layani, Michael; Cooperstein, Ido; Sachyani, Ela; Cohn, Daniel; Magdassi, Shlomo

    2016-06-01

    On page 4449, D. Cohn, S. Magdassi, and co-workers describe a general and facile method based on 3D printing of methacrylated macromonomers to fabricate shape-memory objects that can be used in flexible and responsive electrical circuits. Such responsive objects can be used in the fabrication of soft robotics, minimal invasive medical devices, sensors, and wearable electronics. The use of 3D printing overcomes the poor processing characteristics of thermosets and enables complex geometries that are not easily accessible by other techniques.

  5. Self-Assembled Monolayers: Star-Shaped Crystallographic Cracking of Localized Nanoporous Defects (Adv. Mater. 33/2015).

    Science.gov (United States)

    Renner, Frank Uwe; Ankah, Genesis Ngwa; Bashir, Asif; Ma, Duancheng; Biedermann, P Ulrich; Shrestha, Buddha Ratna; Nellessen, Monika; Khorashadizadeh, Anahita; Losada-Pérez, Patricia; Duarte, Maria Jazmin; Raabe, Dierk; Valtiner, Markus

    2015-09-02

    On page 4877, F. U. Renner, A. Bashir, M. Valtiner, and co-workers describe a star-like dealloying corrosion morphology that appears during the localized attack of smooth well-prepared Cu-Au surfaces. The surfaces are initially protected by thiol or selenol inhibitior films. Localized dealloying of Cu-Au produces nanoporous gold under stress and crystallographic cracks - thereby opening a new approach combining surface science with nanoscale mechanical testing.

  6. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Science.gov (United States)

    Chardonnet, Pascal

    2015-12-01

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d'Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  7. Carbon Nanotubes: Ultrabreathable and Protective Membranes with Sub-5 nm Carbon Nanotube Pores (Adv. Mater. 28/2016).

    Science.gov (United States)

    Bui, Ngoc; Meshot, Eric R; Kim, Sangil; Peña, José; Gibson, Phillip W; Wu, Kuang Jen; Fornasiero, Francesco

    2016-07-01

    A flexible membrane with sub-5 nm single-walled carbon nanotube (SWNT) pores is developed by F. Fornasiero and co-workers, as described on page 5871, for application as a key component of protective, yet breathable fabrics. The SWNTs are shown to enable exceptionally fast transport of water vapor under a concentration driving force. Thus, membranes having SWNTs as moisture-conductive pores feature outstanding breathability and provide a high degree of protection from biological threats by size exclusion.

  8. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Energy Technology Data Exchange (ETDEWEB)

    Chardonnet, Pascal [Coordinator IRAP PhD EMJD, Université de Nice 28, avenue Valrose 06103 Nice (France); LAPTh, Université de Savoie, CNRS, B.P. 110, Annecy-le-Vieux F-74941 (France); ICRANet, Piazza della Repubblica 10, 65122 Pescara (Italy); Department for Theoretical Nuclear Physics, National Research Nuclear University Moscow Engineering Physics Institute, MEPhI, Moscow (Russian Federation)

    2015-12-17

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  9. Poliitikud võtavad alma mater'i üle / Alar Karis ; küsitlenud Nils Niitra

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2010-01-01

    Edaspidi peaks valima rektorit 11-liikmeline nõukogu, kuhu kuuluvad inimesed väljastpoolt ülikooli. Oma arvamust selle kohta avaldavad Tallinna Ülikooli rektor Rein Raud, Tartu Ülikooli professor Talis Bachmann ja professor Mati Kilp

  10. Organosilica: Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Frameworks (Adv. Mater. 17/2016).

    Science.gov (United States)

    Chen, Yu; Shi, Jianlin

    2016-05-01

    Organic-inorganic hybrid materials can combine the advantages of organic and inorganic materials, and overcome their drawbacks accordingly. On page 3235, Y. Chen and J. L. Shi review and discuss research progress on the design, synthesis, structure, and composition control of organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs). Extensive applications of MONs in nanotechnology, mainly in nanomedicine, nanocatalysis and nanofabrication are discussed.

  11. Photonic Crystals: Two-Dimensional Programmable Manipulation of Magnetic Nanoparticles on-Chip (Adv. Mater. 15/2014)

    DEFF Research Database (Denmark)

    Sarella, Anandakumar; Torti, Andrea; Donolato, Marco

    2014-01-01

    P. Vavassori and co-workers demonstrate on page 2384 that field-controlled displacement of magnetic domain walls in ferromagnetic nano-ring structures allows for capture and 2-dimensional remote manipulation of fluidborne magnetic nanoparticles over a chip surface....

  12. Phosphorene: Enhanced Photoresponse from Phosphorene-Phosphorene-Suboxide Junction Fashioned by Focused Laser Micromachining (Adv. Mater. 21/2016).

    Science.gov (United States)

    Lu, Junpeng; Carvalho, Alexandra; Wu, Jing; Liu, Hongwei; Tok, Eng Soon; Neto, Antonio H Castro; Özyilmaz, Barbaros; Sow, Chorng Haur

    2016-06-01

    On page 4090, B. Özyilmaz, C. H. Sow, and co-workers use a focused laser beam to modify the surface of a phosphorene device. With a simple focused laser beam, a part of the phosphorene can be scanned and converted into phosphorene-suboxide species, leaving behind a functional and active phosphorene-phosphorene suboxide junction in the device. Once the junction is formed, the photoresponsivity and photocurrent distribution of the device can be significantly altered with a qualitative difference in behavior. Photovoltaic-like behavior is observed, which is not found in the pristine sample. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Microspheres: Microfluidic Generation of Monodisperse and Photoreconfigurable Microspheres for Floral Iridescence-Inspired Structural Colorization (Adv. Mater. 26/2016).

    Science.gov (United States)

    Yeo, Seon Ju; Park, Kyung Jin; Guo, Kai; Yoo, Pil J; Lee, Seungwoo

    2016-07-01

    Flowering plants have advanced their colorization strategies to divide incoming white light into spatially sequenced vivid colors, especially by using 2D grating diffractive motifs. On page 5268, P. J. Yoo, S. Lee, and co-workers conceive a new idea for a microfluidic approach to mimic this wonderful biological strategy and its practical application to the color encoding of colloidal particles. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Ferromagnetism: Sulfur Doping Induces Strong Ferromagnetic Ordering in Graphene: Effect of Concentration and Substitution Mechanism (Adv. Mater. 25/2016).

    Science.gov (United States)

    Tuček, Jiří; Błoński, Piotr; Sofer, Zdeněk; Šimek, Petr; Petr, Martin; Pumera, Martin; Otyepka, Michal; Zbořil, Radek

    2016-07-01

    R. Zbořil and co-workers show that doping a graphene lattice with sulfur induces magnetic centers which display ferromagnetic order below ≈62 K. As described on page 5045, sulfur doping promotes magnetically active configurations resembling the gamma-thiothiapyrone motif. Enhanced magnetic properties of sulfur-doped graphene are attributed to two unpaired electrons from each sulfur atom injected into the graphene conducting band where they are delocalized between the S and C atoms. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Batteries: encapsulated monoclinic sulfur for stable cycling of li-s rechargeable batteries (adv. Mater. 45/2013).

    Science.gov (United States)

    Moon, San; Jung, Young Hwa; Jung, Wook Ki; Jung, Dae Soo; Choi, Jang Wook; Kim, Do Kyung

    2013-12-03

    On page 6547 Do Kyung Kim, Jang Wook Choi and co-workers describe a highly aligned and carbon-encapsulated sulfur cathode synthesized with an AAO template that exhibits a high and long cycle life, and the best rate capability based on the complete encapsulation of sulfur (physical) and implementation of the monoclinic sulfur phase (chemical). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Nanopillars: Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy (Adv. Mater. 10/2012)

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hübner, Jörg; Boisen, Anja

    2012-01-01

    M. S. Schmidt et al. describe on page OP11 a simple, two-step fabrication process to as-semble flexible, freestanding nanopillars into large-area substrates. These substrates can be made using readily available silicon-processing equipment and are suitable for SERS, having a large, uniform Raman ...

  17. Pulsed Lasers: Pulsed Lasers Employing Solution-Processed Plasmonic Cu3- x P Colloidal Nanocrystals (Adv. Mater. 18/2016).

    Science.gov (United States)

    Liu, Zeke; Mu, Haoran; Xiao, Si; Wang, Rongbin; Wang, Zhiteng; Wang, Weiwei; Wang, Yongjie; Zhu, Xiangxiang; Lu, Kunyuan; Zhang, Han; Lee, Shuit-Tong; Bao, Qiaoliang; Ma, Wanli

    2016-05-01

    Q. Bao, W. Ma and co-workers demonstrate the usage of plasmonic Cu3-x P colloidal nanocrystals as a new type of tunable saturable absorber for the generation of high-energy pulses in a fiber laser. As described on page 3535, these low-cost, solution-processed, next-generation nonlinear optical materials can be harnessed for applications in signal processing and optical communication. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Flexible Batteries: Hierarchical Assemblies of Carbon Nanotubes for Ultraflexible Li-Ion Batteries (Adv. Mater. 31/2016).

    Science.gov (United States)

    Ahmad, Shahab; Copic, Davor; George, Chandramohan; De Volder, Michael

    2016-08-01

    An advanced battery architecture composed of 3D carbon nanotube (CNT) current collectors is used to mitigate stresses in flexible batteries. On Page 6705, C. George, M. De Volder, and co-workers describe the fabrication process and characteristics of this new generation of ultraflexible batteries, which show high rate and cyclablility. These batteries may find applications in the powering of flexible displays and logics. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Cancer Immunotherapy: Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy (Adv. Healthcare Mater. 10/2016).

    Science.gov (United States)

    Wang, Xiupeng; Li, Xia; Yoshiyuki, Kazuko; Watanabe, Yohei; Sogo, Yu; Ohno, Tadao; Tsuji, Noriko M; Ito, Atsuo

    2016-05-01

    A plain mesoporous silica (MS) nanoparticle without any immunomodulatory molecules enhances anti-cancer immunity in vivo. On page 1169, X.P. Wang, N. M. Tsuji, A. Ito and co-workers show that a plain MS nanoparticle promotes both Th1 and Th2 immune responses, and enhances the effector memory of CD4(+) and CD8(+) T cell populations in the three most important immune organs (bone marrow, lymph node and spleen) of mice. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Carcinomatose meníngea Carcinomatosis of the meninges: a case report

    Directory of Open Access Journals (Sweden)

    Milberto Scaff

    1970-03-01

    Full Text Available Registro de um caso de carcinomatose meníngea. O diagnóstico foi estabelecido pela evolução e pelo encontro de células neoplásicas no líquido cefalorraqueano. A necropsia mostrou existir carcinoma papilífero do estômago, com metástases nas supra-renais, no espaço retroperitonial, no espaço sub-aracnóideo comprometendo raízes nervosas, nas paredes e na luz de vasos linfáticos, na espessura da dura-mater e no tecido nervoso medular.A case of carcinoma of the meninges, diagnosed through the clinical picture and the finding of neoplastic cells in the cerebrospinal fluid is reported. The post-mortem examination showed a papillary carcinoma of the stomach with metastases in the retroperitoneal space, in the subarachnoideal space infiltrating the spinal roots, in the lymphatic vessels of the nerve trunks, in the dura-mater and the spinal cord.

  1. Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex--an experimental model for vascular dysfunctions in cluster headache.

    Science.gov (United States)

    Gottselig, R; Messlinger, K

    2004-03-01

    Cluster headache is characterized by typical autonomic dysfunctions including facial and intracranial vascular disturbances. Both the trigeminal and the cranial parasympathetic systems may be involved in mediating these dysfunctions. An experimental model was developed in the rat to measure changes in lacrimation and intracranial blood flow following noxious chemical stimulation of facial mucosa. Blood flow was monitored in arteries of the exposed cranial dura mater and the parietal cortex using laser Doppler flowmetry. Capsaicin (0.01-1 mm) applied to oral or nasal mucosa induced increases in dural and cortical blood flow and provoked lacrimation. These responses were blocked by systemic pre-administration of hexamethonium chloride (20 mg/kg). The evoked increases in dural blood flow were also abolished by topical pre-administration of atropine (1 mm) and [Lys1, Pro2,5, Arg3,4, Tyr6]-VIP (0.1 mm), a vasoactive intestinal polypeptide (VIP) antagonist, onto the exposed dura mater. We conclude that noxious stimulation of facial mucosa increases intracranial blood flow and lacrimation via a trigemino-parasympathetic reflex. The blood flow responses seem to be mediated by the release of acetylcholine and VIP within the meninges. Similar mechanisms may be involved in the pathogenesis of cluster headache.

  2. A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated hypertrophic pachymeningitis presenting with multiple cranial nerve palsies and diabetes insipidus.

    Science.gov (United States)

    Yasuda, Ken; Sainouchi, Makoto; Goto, Masahiro; Murase, Nagako; Ohtani, Ryo; Nakamura, Michikazu

    2016-05-31

    A 61-year-old woman developed hearing difficulties and became thirsty after experiencing cold symptoms. A neurological examination revealed a loss of odor sensation, facial palsy, dysphasia, and dysarthria. Vocal cord palsy was observed during pharyngoscopy. Brain magnetic resonance imaging (MRI) showed a thickened pituitary stalk and swelling of the pituitary gland, but no high signal intensity regions were seen in the posterior portion of the pituitary gland. Gadolinium-enhanced MRI demonstrated a thickened dura mater over the anterior cranial fossa. A biopsy specimen of the thickened dura mater showed fibrosis, granulomatous inflammation, and necrotic foci. Blood tests detected myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). The patient's urine osmolarity was low even though she exhibited hypernatremia. We diagnosed her with hypertrophic pachymeningitis associated with MPO-ANCA and diabetes insipidus. The patient received two courses of 5-day high-dose intravenous methylprednisolone (1.0 g/day), and was subsequently administered oral prednisolone, which gradually relieved her symptoms. However, the patient's symptoms recurred despite the high-dose prednisolone treatment. It was difficult to control the patient's symptoms in this case with oral prednisolone monotherapy, but combined treatment with cyclosporine resulted in sustained remission. It is considered that patients with MPO-ANCA-positive hypertrophic pachymeningitis require combination therapy with prednisolone and immunosuppressive agents at an early stage.

  3. Imaging of peripheral PNET: Common and uncommon locations

    Energy Technology Data Exchange (ETDEWEB)

    Khong, P.L.; Chan, G.C.F.; Shek, T.W.H.; Tam, P.K.H.; Chan, F.L

    2002-04-01

    AIM: We present the imaging features of peripheral primitive neuroectodermal tumour (PNET) in eight children, highlighting the unusual locations of this tumour in three children. MATERIALS AND METHODS: At presentation, the tumours were studied with magnetic resonance imaging (MRI; n = 6), computed tomography (CT; n = 7) and ultrasound (US;n = 1). The diagnoses were confirmed histologically (n = 8), immunohistochemically (n 8), by cytogenetics (n = 3) and electron microscopy (n = 1). Correlation with gross pathology, histology, treatment and outcome were obtained. RESULTS: The tumours were located in the chest wall (n = 2), shoulder, pelvis, small bowel mesentery, adrenal gland, dura mater and skin and subcutaneous tissue of the abdominal wall (n = 1 each). Peripheral PNET arising from the small bowel mesentery, adrenal gland and dura mater have not been previously reported in the English literature. The tumours were mainly large (mean size: 10{center_dot}6 cm) and infiltrative. All tumours were heterogeneously hyperintense on T2-weighted MRI, heterogeneously iso/hypodense on CT and had variable contrast enhancement. Most tumours were heterogeneously hypointense to muscle on T1-weighted MRI. US showed a hypoechoic mass with a cystic component. CONCLUSION: Peripheral PNET can occur in unusual locations. The clinical and imaging features of peripheral PNET are non-specific, making tissue diagnosis essential. PNET should be included in the differential diagnosis of aggressive soft tissue tumours in children. Khong, P.L. et al. (2002)

  4. Cranioplastia primária nos afundamentos do crânio com ferimento aberto do couro cabeludo

    Directory of Open Access Journals (Sweden)

    Darcy de Freitas Vellutini

    1972-06-01

    Full Text Available Os autores referem 13 casos de afundamentos crânio-encefálicos pós-traumáticos com ferimento aberto do couro cabeludo nos quais foi usado o metilmetacrilato em uma única intervenção cirúrgica. A sede do afundamento era frontal em 9 casos, parietal em dois, parieto-temporal em um e parieto-occipital em um. Os afundamentos interessavam apenas a tábua óssea em 5 casos, estavam associados a lesão de dura-mater em três e também do tecido cerebral em 5. Foi realizada cranioplastia simples em 5 casos e, em 8, ela foi precedida de plástica de dura-mater. O seguimento pós-operatório variou de dois meses a dois anos; até o momento não foi assinalada ocorrência de infecção ou de fenômeno de rejeição da prótese que obrigasse a sua retirada.

  5. Quantification of the edge effect in calcified bioprosthetic tissues.

    Science.gov (United States)

    Wika, K E; Utoh, J; Brown, J; Harasaki, H

    1993-10-01

    In bioprosthetic tissue samples that had been implanted in the subcutaneous space of rats, and recurring pattern of calcification was observed. In this pattern, which we call the edge effect, the interior of the tissue is calcified and is surrounded and separated from the subcutaneous fluid by a zone that is free from calcification. The edge effect has been qualitatively described in the literature for subcutaneous implants and for valve leaflets, and it may be related to the mechanism of calcification for these materials. The thickness of the calcification free outer layer was quantified for glutaraldehyde treated bovine pericardium, glycerol treated bovine pericardium, glutaraldehyde treated human dura mater, and glycerol treated human dura mater. The edge effect values were found to be unique and consistent for each material type, and they were inversely related to the shrinkage temperatures and the calcium contents of the materials. It was determined that the chemical treatment was more important than the tissue type in determining the edge effect value.

  6. The role of CT in evaluation of the effectiveness of embolisation of spinal dural arteriovenous fistulae with N -butyl cyanoacrylate

    Energy Technology Data Exchange (ETDEWEB)

    Cognard, C. [Service de Neuroradiologie Charcot, Hopital de la Salpetriere, Paris (France); Miaux, Y. [Service de Neuroradiologie Charcot, Hopital de la Salpetriere, Paris (France); Pierot, L. [Service de Neuroradiologie Charcot, Hopital de la Salpetriere, Paris (France); Weill, A. [Service de Neuroradiologie Charcot, Hopital de la Salpetriere, Paris (France); Martin, N. [Service de Neuroradiologie Charcot, Hopital de la Salpetriere, Paris (France); Chiras, J. [Service de Neuroradiologie Charcot, Hopital de la Salpetriere, Paris (France)

    1996-10-01

    A failed embolisation of a spinal dural arteriovenous fistula (AVF), because a pedicular injection has not reached the initial venous compartment, must be identified immediately, to allow prompt surgery and thus avoid clinical deterioration. The purpose of our study was to determine the role of CT in confirming a complete cure just after embolisation with N -butyl cyanoacrylate (NBCA). Seven patients embolised for spinal dural AVFs with perimedullary venous drainage had an immediate postembolisation CT scan. In six patients a complete cure was achieved, with a normal postembolisation angiogram in five cases. Just after injection of NBCA, we were unable to determine on plain films whether or not the glue had reached the draining vein in six of seven cases. The postembolisation CT showed various patterns: in two cured patients, the glue was visible in the inner surface of the dura mater and therefore on the venous side. In five cases, the glue was approaching the dura mater around the cord or seemed to reach its surface: in the four patients cured, the glue column was 7-18 mm high, whereas it was less than 2 mm high in the patient with angiographic proof of recurrent fistula. The follow-up angiogram remains the only way to confirm a durable cure. We suggest that immediate postembolisation CT may help in assessing endovascular treatment of spinal dural AVFs. (orig.). With 4 figs., 2 tabs.

  7. Endoscopic procurement of allograft tympano-ossicular systems: valuable to replace the Schuknecht bone plug technique?

    Science.gov (United States)

    Caremans, Jeroen; Hamans, Evert; Muylle, Ludo; Van de Heyning, Paul; Van Rompaey, Vincent

    2015-03-01

    Recently, our group demonstrated the technical feasibility of allograft tympano-ossicular systems (ATOS) procurement directly through the external auditory canal by using a rigid endoscope. This novel technique has several advantages compared to the traditional transcranial Schuknecht bone plug technique: it avoids contact with the dura mater, it is less time-consuming and it doesn't require a thorough reconstruction of the donor. In our tissue bank, we are currently transitioning from the transcranial procurement technique to the endoscopic procurement technique. The learning curve to master the endoscopic technique is steep but our preliminary results suggest that the percentage of good quality endoscopically procured ATOS is at least similar to the percentage of good quality transcranially procured ATOS dissected from the temporal bone plug. Additionally, the number of donations has increased significantly. By avoiding contact with the dura mater and therefore eliminating the risk of potential prion disease transmission, this technical evolution in procurement technique might allow dedicated tissue banks to (re-)introduce ATOS procurement and implantation.

  8. Granulomatous pachymeningitis around the sella turcica (Tolosa-Hunt syndrome) involving the hypophysis--case report.

    Science.gov (United States)

    Kita, Daisuke; Tachibana, Osamu; Nagai, Yukihiro; Sano, Hiroki; Yamashita, Junkoh

    2007-02-01

    A 50-year-old female presented with right painful abducens nerve palsy persisting for 4 months and mild panhypopituitarism with diabetes insipidus for 6 months. T(1)-weighted magnetic resonance (MR) imaging of the sellar region showed a homogeneously enhanced mass lesion in the right cavernous sinus which seemed to extend from the swollen pituitary gland. T(2)-weighted MR imaging clearly showed the mass in the right cavernous sinus and the thickened dura mater of the sellar floor as hypointense, and the enlarged pituitary gland as isointense. Biopsy of the thickened dura mater and swollen pituitary gland was performed via the transsphenoidal approach. Histological examination revealed inflammation and collagen fiber formation in these regions. The diagnosis was secondary panhypophysitis resulting from granulomatous pachymeningitis involving the cavernous sinus (Tolosa-Hunt syndrome). Corticosteroid therapy was begun after the biopsy. Her periorbital pain and diplopia were relieved, but diabetes insipidus persisted. Follow-up MR imaging showed a decrease in the volumes of the pituitary gland and the mass in the cavernous sinus.

  9. Head movement, an important contributor to human cerebrospinal fluid circulation

    Science.gov (United States)

    Xu, Qiang; Yu, Sheng-Bo; Zheng, Nan; Yuan, Xiao-Ying; Chi, Yan-Yan; Liu, Cong; Wang, Xue-Mei; Lin, Xiang-Tao; Sui, Hong-Jin

    2016-01-01

    The suboccipital muscles are connected to the upper cervical spinal dura mater via the myodural bridges (MDBs). Recently, it was suggested that they might work as a pump to provide power for cerebrospinal fluid (CSF) circulation. The purpose of this study was to investigate effects of the suboccipital muscles contractions on the CSF flow. Forty healthy adult volunteers were subjected to cine phase-contrast MR imaging. Each volunteer was scanned twice, once before and once after one-minute-head-rotation period. CSF flow waveform parameters at craniocervical junction were analyzed. The results showed that, after the head rotations, the maximum and average CSF flow rates during ventricular diastole were significantly increased, and the CSF stroke volumes during diastole and during entire cardiac cycle were significantly increased. This suggested that the CSF flow was significantly promoted by head movements. Among the muscles related with head movements, only three suboccipital muscles are connected to the upper cervical spinal dura mater via MDBs. It was believed that MDBs might transform powers of the muscles to CSF. The present results suggested that the head movements served as an important contributor to CSF dynamics and the MDBs might be involved in this mechanism. PMID:27538827

  10. Efeito da composição genética e de fatores de meio sobre a produção de leite, a duração da lactação e a produção de leite por dia de intervalo de partos de vacas mestiças Holandês-Gir Effects of genetic composition and environmental factors on milk production, lactation length and milk production per day of calving interval in crossbred Holstein-Gyr cows

    Directory of Open Access Journals (Sweden)

    J.R. Glória

    2006-12-01

    Full Text Available Utilizou-se o método dos quadrados mínimos para avaliar os efeitos da composição genética (CG e dos fatores de meio sobre a produção total de leite (PL, duração da lactação (DL e produção de leite por dia de intervalo de partos (P/I (n=2.016 de 822 vacas mestiças (1/2, 3/4 e 7/8 Holandês-Gir, criadas no oeste de Minas Gerais. O efeito da capacidade prevista de transmissão (PTA dos touros da raça Holandesa sobre a PL de suas filhas cruzadas também foi avaliado. O efeito da CG sobre as três características foi importante fonte de variação, sendo que a PL, a DL e a P/I aumentaram com o incremento da contribuição da raça Holandesa. As médias para PL foram 3549,3±39,3kg, 4331,7±56,2kg e 4515,7±115,9kg; para DL, 306,5±1,9 dias, 328,2±2,5 dias e 337,0±4,6 dias; e para P/I, 9,0±0,1kg, 10,6±0,2kg e 11,0±0,3kg por dia, respectivamente, para vacas 1/2, 3/4 e 7/8 Holandês-Gir. Estação de parição foi importante fonte de variação da PL das vacas 3/4 e da DL de vacas 3/4 e 1/2 Holandês-Gir. Maiores PL e DL foram observadas nas lactações iniciadas no final do período chuvoso. O efeito da idade da vaca ao parto sobre a PL foi linear ascendente para vacas 1/2 e 3/4 Holandês-Gir e curvilíneo para vacas 7/8 Holandês-Gir, com produção máxima (4733,5 kg na segunda lactação. Para DL esse efeito foi curvilíneo para vacas 1/2 e 3/4 Holandês-Gir, com mínimos de 284,7 e 309,2 dias aos 7,3 e 5,7 anos de idade, respectivamente; e linear descendente para vacas 7/8 Holandês-Gir. Já o efeito da idade da vaca sobre P/I foi linear ascendente para o conjunto 3/4 e 7/8, e curvilíneo para as 1/2 Holandês-Gir, com o máximo de 9,5kg/dia de intervalo de partos aos 6,4 anos de idade. O efeito do PTA de touros sobre a PL de suas filhas não foi diferente de zero. As estimativas de repetibilidade para PL foram 0,72, 0,69 e 0,63, respectivamente, para vacas 1/2, 3/4 e 7/8 Holandês-Gir.The effects of genetic composition (GC and

  11. Application of biological dural graft made by meninges from porkers

    Institute of Scientific and Technical Information of China (English)

    Peng Liu; Shengping Huang; Songtao Qi

    2007-01-01

    BACKGROUND: Presently, over 40 kinds of dural grafts have been successively used in clinic. Among them, lyophilized human dura mater with good histocompatibility and less complications is applied most widely. But there are a few reports on cases of infected spongiform encephalopathy following application of lyodura. More ideal repair materials deserve to be further investigated.OBJECTIVE: To investigate the efficiency and safety of biological dural graft made by meninges from porkers to repair meningeal injury.DESIGN: A self-control observation.SETTING: Wuhan General Hospital of Guangzhou Military Area Command of Chinese PLA.MATERIALS: Sixteen New Zealand Rabbits, of either gender, weighing from 2 to 3 kg, of clean grade Ⅱ,with the age of 0.5 - 1 year, were involved in this experiment. The involved rabbits were provided by the Animal Experimental Center of the First Military Medical University of Chinese PLA. Biological surgical patch (dural graft) was developed by Guangdong Guanhao Biotechnological Co.,Ltd. It was processed by using meninges from porkers by tissue engineering technology.METHODS: This experiment was carried out in the Experimental Center of the 157 Hospital of Chinese PLA between December 2003 and June 2004. ① The experimental rabbits were anesthetized. Dura mater was exposed from two sides ofpostmedial line of coronal suture. A rectangular dura mater about 8 mm × 8mm in size was cut off. Then a biological surgical patch (dural graft) was sheared into insert with 8 mm diameter and sutured. The left dura mater was untouched and used as control. Scalp was sutured, and postoperative wound healing and recovery were observed. ②The anesthetized rabbits were sacrificed at postoperative 3, 14, 30 and 90 days, 4 rabbits once. The whole head was cut off, and its scalp was removed.Afterwards, the head was fixed by formalin. Tissues in operative site were obtained, performed routine paraffin embedding, sliced and conducted HE staining, finally, the

  12. Effect of operating microscope light on brain temperature during craniotomy.

    Science.gov (United States)

    Gayatri, Parthasarathi; Menon, Girish G; Suneel, Puthuvassery R

    2013-07-01

    Operating microscopes used during neurosurgery are fitted with xenon light. Burn injuries have been reported because of xenon microscope lighting as the intensity of xenon light is 300 W. We designed this study to find out if the light of operating microscope causes an increase in temperature of the brain tissue, which is exposed underneath. Twenty-one adult patients scheduled for elective craniotomies were enrolled. Distal esophageal temperature (T Eso), brain temperature under the microscope light (T Brain), and brain temperature under dura mater (T Dura) were measured continuously at 15-minute intervals during microscope use. The irrigation fluid temperature, room temperature, intensity of the microscope light, and the distance of the microscope from the brain surface were kept constant. The average age of the patients was 44±15 years (18 males and 3 females). The mean duration of microscope use was 140±39 minutes. There were no significant changes in T Brain and T Dura and T Eso over time. T Dura was significantly lower than T Brain both at time 0 and 60 minutes but not at 90 minutes. T Brain was significantly lower than T Eso both at time 0 and 60 minutes but not at 90 minutes. The T Dura remained significantly lower than T Eso at 0, 60, and 90 minutes. Our study shows that there is no significant rise in brain temperature under xenon microscope light up to 120 minutes duration, at intensity of 60% to 70%, from a distance of 20 to 25 cm from the brain surface.

  13. Retinal plasma extravasation in animals but not in humans: implications for the pathophysiology of migraine.

    Science.gov (United States)

    May, A; Shepheard, S L; Knorr, M; Effert, R; Wessing, A; Hargreaves, R J; Goadsby, P J; Diener, H C

    1998-07-01

    High-intensity electrical stimulation of the trigeminal ganglion is accompanied by mast cell degranulation, vasodilatation, increased endothelial permeability and leakage of albumin from postcapillary venules within the dura mater. Overall, the histological appearance suggests an evolving sterile inflammatory response. This neurogenic inflammation within the meninges has been suggested as a model to explain the pain in migraine and cluster headache, and has been used to characterize the pharmacology of anti-migraine compounds. Using the rat model of neurogenic inflammation, the albumin extravasation ratio (stimulated : unstimulated side) in vehicle-treated animals in the dura and retina was 1.60 +/- 0.11 and 1.76 +/- 0.18, respectively (n = 10; values are mean +/- SEM). Pretreatment with sumatriptan (n = 9) produced a highly significant reduction in the ratio of extravasation within the dura to 1.10 +/- 0.06 (P = 0.002) and in the retina to 0.96 +/- 0.06 (P = 0.001), as did the neurokinin-1 receptor antagonist RP 67580 (n = 12) in the dura (1.04 +/- 0.11, P = 0.002) and retina (1.08 +/- 0.06, P = 0.001). These data demonstrate increased endothelial permeability and leakage of albumin not only in the dura but also in the retina. In a second stage we investigated possible extravasation in the human retina in acute migraine (n = 8) and cluster headache (n = 5) using fluorescein or indocyanine angiography. No increased endothelial permeability or leakage of dye could be found in the human retinal or choroidal vessels during headache attacks or in the headache-free interval in persons suffering from both migraine and cluster headache. These data raise the possibility that neurogenic inflammation is not a major factor in headache attacks in migraine or cluster headache.

  14. "LA LEY PAREJA NO ES DURA" REPRESENTACIONES DE LA CRIMINALIDAD Y LA JUSTICIA EN LA LIRA POPULAR CHILENA

    Directory of Open Access Journals (Sweden)

    DANIEL PALMA ALVARADO

    2006-06-01

    Full Text Available El estudio ofrece una aproximación a la historia social y urbana del Chile liberal y salitrero (1880-1920, a partir de las liras populares. Estos pliegos de poesía popular permiten descubrir y reconstruir las sensibilidades y representaciones sociales en torno a los más diversos tópicos, de los cuales se examinan en este artículo aquellos referidos a la criminalidad y la justicia, al crimen y al castigo. El análisis de las liras arroja una completa hermenéutica popular que aporta importantes matices a la comprensión tradicional de estos temas, dando cuenta de cuestiones como la violencia urbana, el clasismo del aparato judicial y el debate en torno a la pena de muerte. Asimismo, se reflexiona sobre la circulación de las liras entre la población urbana, observándose que el circuito de la cultura popular en que estaban inmersas las liras, se comienza a vincular de manera dialógica con otras expresionesThrough examining the liras populares, this study offers an approximation to social and urban history in the liberal and nitrate-funded Chilean era (1880-1920. These single sheets of popular poetry allow us to uncover social representations and sensibilities around wide topics. This article analyzes issues regarding criminality and justice, crime and punishment. The liras' analysis explores a popular hermeneutic that nuances traditional interpretations around Chilean crime and judiciary, opening new approaches to popular understandings on urban violence, the classism of the judiciary apparatus, and the debates concerning dead penalty. Likewise, this article explores the problem of the liras' urban distribution, circulation and impact, looking after the popular culture circuits that were growingly, dialogically linked to other expressions of cultural production

  15. Full-Scale Evaluation of DuraDeck (registered trademark) and MegaDeck (trademark) Matting Systems

    Science.gov (United States)

    2013-07-01

    tightened using a cordless drill with a socket designed to fit the nuts. During installation, the manpower was divided as follows: two men carried the...at io n (in .) Passes DURADECK® DEFORMATION MEASURED ON MAT SURFACE F-15 LANE 1 F-15 LANE 2 25 KIP FORKLIFT ERDC/GSL TR-13-27 21 F-15E Lane 1...than initially expected. Inspection of the panels 0.0 0.4 0.8 1.2 1.6 2.0 2.4 2.8 3.2 0 50 100 150 200 250 300 350 400 A ve ra ge D ef or m at io n

  16. Donaldson Company, Inc., Dura-Life #0701607 Filtration Media(Tested October 2011) (ETV Baghouse Filtration Products) Verification Report

    Science.gov (United States)

    Baghouses are air pollution control devices used to control particulate emissions from stationary sources and are among the technologies evaluated by the APCT Center. Baghouses and their accompanying filter media have long been one of the leading particulate control techniques fo...

  17. Queneau, Perec, Duras : Trois manières de boire dans le roman français

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    Véronique Montémont

    2009-09-01

    Full Text Available L’alcool et les alcools sont des thèmes étroitement associés au monde littéraire : si l’on en doutait, une recherche dans la base Frantext, qui comporte près de 3952 textes français et francophones, suffirait à nous en convaincre : une requête sur le lemme alcool ne ramène pas moins de 3338 occurrences. Si l’on élargit l’isotopie considérée, on trouve 23 372 occurrences de vin, 2953 mentions de bière, 1436 d’eau-de-vie, 834 de Champagne, 122 de cognac… ainsi que quelques dizaines de cuites, r...

  18. Consolidação fiscal nos Estados brasileiros: uma análise de duração

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    Bruno de Paula Rocha

    2008-08-01

    Full Text Available The objective of this paper is to analyze theduration of fiscal consolidation of Brazilianstates in the period 1986-2001. For thispropose, we applied the duration modelsmethodology. We sought to establish the maincharacteristics that explain the probability that astate would remain in fiscal balance, once it hasachieved that position. The non-parametricresults suggest that the probability that fiscalconsolidation will be maintained fallsdramatically after the first year and even moreafter the second year. Parametric analysis showsthat there is a core of relevant variables, such asthe Number of Failures, the PersonnelCosts/Net Current Revenue ratio, the dummyvariable for the years before the BrazilianConstitution of 1988, the dummy variable forthe years after the refinance law 9496/97 andthe polarization in the preferences of the partiesthat compose the Legislative Assembly.

  19. Deep-Sea DuraFET: A Pressure Tolerant pH Sensor Designed for Global Sensor Networks.

    Science.gov (United States)

    Johnson, Kenneth S; Jannasch, Hans W; Coletti, Luke J; Elrod, Virginia A; Martz, Todd R; Takeshita, Yuichiro; Carlson, Robert J; Connery, James G

    2016-03-15

    Increasing atmospheric carbon dioxide is driving a long-term decrease in ocean pH which is superimposed on daily to seasonal variability. These changes impact ecosystem processes, and they serve as a record of ecosystem metabolism. However, the temporal variability in pH is observed at only a few locations in the ocean because a ship is required to support pH observations of sufficient precision and accuracy. This paper describes a pressure tolerant Ion Sensitive Field Effect Transistor pH sensor that is based on the Honeywell Durafet ISFET die. When combined with a AgCl pseudoreference sensor that is immersed directly in seawater, the system is capable of operating for years at a time on platforms that cycle from depths of several km to the surface. The paper also describes the calibration scheme developed to allow calibrated pH measurements to be derived from the activity of HCl reported by the sensor system over the range of ocean pressure and temperature. Deployments on vertical profiling platforms enable self-calibration in deep waters where pH values are stable. Measurements with the sensor indicate that it is capable of reporting pH with an accuracy of 0.01 or better on the total proton scale and a precision over multiyear periods of 0.005. This system enables a global ocean observing system for ocean pH.

  20. Excavación de galerías en rocas duras mediante máquina tuneladora (minador continuo

    Directory of Open Access Journals (Sweden)

    Víé, G.

    1979-10-01

    Full Text Available This article studies the most outstanding characteristics of continuous boring machines and their drilling tools, giving in hard rock excavation a sizable economy of 30 to 50% relative to the hammering and blasting techniques. The paper goes through the development of these machines from the simple grinding wheel, to the conical roller bit, the excavating crown with an approximate diameter half of the gallery being excavated, the spiral pitch instead of the circular pitch, etc., each providing a number of advantages over the preceding step.

    Se estudian en este articulo las características más sobresalientes de las máquinas tuneladoras continuas, así como las de sus herramientas de perforación, que proporcionan para las rocas de gran dureza un ahorro sobre los métodos de martillo y explosivo entre el 30 y el 50 por 100. Se ve la evolución sufrida por estas máquinas que nos ha llevado hasta la muela de disco simple, el rodillo cónico, la corona de perforación de diámetro —aproximadamente la mitad de la galería excavada—, el paso en espiral en sustitución del circular, etc. que proporcionan una serie de ventajas sobre las anteriores.

  1. Fluorescence behaviour and dural infiltration of meningioma analyzed by 5-ALA based fluorescence: Operating microscope versus mini-spectrometer.

    Science.gov (United States)

    Knipps, Johannes; Beseoglu, Kerim; Kamp, Marcel; Fischer, Igor; Felsberg, Joerg; Neumann, Lisa M; Steiger, Hans-Jakob; Cornelius, Jan F

    2017-08-30

    To compare fluorescence intensity of tumor specimens as measured by a FGS-microscope and a spectrometer, 2.) to evaluate tumor infiltration of dura mater around meningiomas with help of these two different 5-ALA based fluorescence tools and 3.) to correlate fluorescence intensity with histopathological data. In a clinical series menigiomas were resected by 5-ALA fluorescence guided surgery. Fluorescence intensity was semi-quantitatively rated by the surgeon at pre-defined points. Biopsies were harvested and fluorescence intensity measured by a spectrometer and histopathologically analysed. Sampling was realized at the level of the dura in a centrifugal direction. 104 biopsies (n= 13 tumors) were analysed. Specificity and sensitivity of the microscope were 0.96 and 0.53 and of the spectrometer 0.95 and 0.93, respectively. Fluorescence intensity as measured by the spectrometer was correlated to histologically confirmed tumor burden. In a centrifugal direction, tumor burden and fluorescence intensity continuously decreased (along the dural tail). Below a threshold value of 639 arbitrary units no tumor was histologically detectable. At the level of the dura the spectrometer was highly sensitive for detection of meningioma cells. The surgical microscope showed false negative results and missed residual tumor cells in more than half of the cases. The complementary use of both fluorescence tools may improve resection quality. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Microsurgical anatomic study of the parasellar region and its related structures%中颅窝鞍旁区相关结构的外科显微解剖研究

    Institute of Scientific and Technical Information of China (English)

    邵君飞; 傅震; 张岩松; 王海秋; 姚建社

    2009-01-01

    Objective To study the surgical microanatomy of the parasellar region and its Related Structures. Methods The microsurgical dissections were performed on 38 cadaveric heads with the aid of an operating microscope to observe and measure the dura, nerves and vessels in the sphenopetroclival region, and to learn the relationships among the dura, nerves and vessels with histochemical technique. Results In middle cranial fossa, cranial nerves Ⅲ, Ⅳ and Ⅵ, which were enwrapped by arachnoid and dura, entered between the dura of middle cranial fossa. The Meckel's cave, the trigeminal ganglion and its three branchs, just like a glove, were embedded between the dura of middle cranial fossa , and ICA and some venous structures traveled among them. Cavernous sinus and those structures were located in a cave made up of two floors of the middle cranial fossa dura, namely dura mater space. Conclusions We suggest a new constructive conception about this region which is the surgical anatomy based by the parasellar region approach.%目的 提供中颅窝鞍旁区相关解剖学依据,为鞍旁区手术提供帮助.方法 对38例成人尸颅进行手术巨微解剖,测量鞍旁区的硬膜关系、神经与血管走行及相邻结构的关系,并进行组织学观察.结果 在中颅窝,动眼神经、滑车神经、展神经包裹着蛛网膜与硬脑膜深入中颅窝硬膜之间,Meckel腔、三叉神经节及其三个分支包裹着后颅窝蛛网膜与硬脑膜像三指手套深入中颅窝硬膜之间,颈内动脉及颅内、外静脉亦穿行于中颅窝硬膜间;上述结构与海绵窦在中颅窝鞍旁两层硬膜形成一个腔,即硬膜间腔.结论 提出鞍区形态学特点,为中颅窝鞍旁区手术提供解剖学依据.

  3. MR IMAGING OF MENINGEAL CARCINOMATOSIS BY SYSTEMIC MALIGNANCY

    Institute of Scientific and Technical Information of China (English)

    马林; 于生元; 蔡幼铨; 梁丽; 郭行高

    2003-01-01

    Objective.To investigate the magnetic resonance(MR)features of meningeal carcinomatosis,and to improve the ability in understanding and diagnosing meningeal carcinomatosis by MR findings. Methods. Eleven cases with proven meningeal carcinomatosis were studied by conventional and Gd-DTPA enhanced MR imaging. The enhancement patterns and features,as well as the types of meningeal involvement,were retrospectively analyzed. Results. Conventional MR imaging showed no evident meningeal abnormalities. After the administration of Gd-DTPA,abnormal pia mater enhancement was detected in 9 cases,demonstrating as the continuous,thin,and lineal high signal intensity on the brain surface that could descend into the sulci. The abnormal pial enhancement occurred on the cortical surfaces of cerebellum,brainstem,and cerebrum. No abnormal enhancement in the subarach-noid space was found. Abnormal dura-arachnoid enhancement was seen in 3 cases,showing as the continuous,thick,and curvilineal high signal intensity over the convexities or in the tentorium without extension into the cortical sulci. Cerebral dura-arachnoid involvement was found in all 3 cases and one of them also showed abnormal enhancement in cerebellar dura-arachnoid and tentorium. Of the 11 cases,9 with pial involvement had abnormal cerebrospinal fluid(CSF)results,2 involving only the dura-arachnoid had normal CSF results. Conclusion. Meningeal carcinomatosis could be well demonstrated by Gd-DTPA enhanced MR imaging,and its type could be differentiated by the enhancement features. Combined with the clinical information,Gd-enhanced MR imaging may lead to the diagnosis and guide the therapy of meningeal carcinomatosis.

  4. Multimodal integration of EEG, MEG and fMRI data for the solution of the neuroimage puzzle.

    Science.gov (United States)

    Babiloni, Fabio; Mattia, Donetella; Babiloni, Claudio; Astolfi, Laura; Salinari, Serenella; Basilisco, Alessandra; Rossini, Paolo Maria; Marciani, Maria Grazia; Cincotti, Febo

    2004-12-01

    In this paper, advanced methods for the modeling of human cortical activity from combined high-resolution electroencephalography (EEG), magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) data are presented. These methods include a subject's multicompartment head model (scalp, skull, dura mater, cortex) constructed from magnetic resonance images, multidipole source model and regularized linear inverse source estimates of cortical current density. Determination of the priors in the resolution of the linear inverse problem was performed with the use of information from the hemodynamic responses of the cortical areas as revealed by block-designed (strength of activated voxels) fMRI. Examples of the application of these methods to the estimation of the time varying cortical current density activity in selected region of interest (ROI) are presented for movement-related high-resolution EEG data.

  5. Improved estimation of human cortical activity and connectivity with the multimodal integration of neuroelectric and hemodynamic data.

    Science.gov (United States)

    Babiloni, F; Mattia, D; Basilisco, A; Astolfi, L; Cincotti, F; Ding, L; Christine, K; Sweeney, J; Edgar, J C; Miller, G A; He, B

    2005-01-01

    In the last decade, the possibility to noninvasively estimate cortical activity and connectivity has been highlighted by the application of the techniques known as high resolution EEG. These techniques include a subject's multi-compartment head model (scalp, skull, dura mater, cortex) constructed from individual magnetic resonance images, multi-dipole source model, and regularized linear inverse source estimates of cortical current density. More recently, it has proved as the use of information from the hemodynamic responses of the cortical areas as revealed by block-designed (strength of activated voxels) fMRI improves dramatically the estimates of cortical activity and connectivity. Here, we present some applications of such estimation in two set of high resolution EEG and fMRI data, related to the motor (finger tapping) and cognitive (Stroop) tasks. We observed that the proposed technology was able to unveil the direction of the information flow between the cortical regions of interest.

  6. Lumbar subarachnoid hematoma following an epidural blood patch for meningeal puncture headache related to the implantation of an intrathecal drug delivery system.

    Science.gov (United States)

    Hustak, Erik C; Engle, Mitchell P; Viswanathan, Ashwin; Koyyalagunta, Dhanalakshmi

    2014-01-01

    Persistent meningeal puncture headache (MPH) is a known complication following both intentional and unintentional puncture of the dura mater.  We present a case of persistent MPH following implantation of an intrathecal drug delivery system (IDDS). Two separate epidural blood patches (EBP) were performed under radiographic guidance with contrast visualization of the epidural space on postoperative days 16 and 28, respectively. The case was complicated by the development of a symptomatic lumbar subarachnoid hematoma diagnosed on postoperative day 35. The patient subsequently underwent a laminectomy, evacuation of the hematoma, and explanation of the IDDS. This case illustrates a potential unique morbidity associated with the EBP in a patient with an IDDS. The report concludes with a brief review of MPH followed by a discussion of possible mechanisms underlying this complication.

  7. PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor

    DEFF Research Database (Denmark)

    Jansen-Olesen, Inger; Baun, Michael; Amrutkar, Dipak V;

    2014-01-01

    nucleus caudalis (TNC) was quantified by EIA. Regulation of NOS-enzymes caused by VIP and PACAP was investigated in dura mater, TG and TNC by measuring the conversion of L-[3H]arginine to L-[3H]citrulline. Co-expression of PACAP, neuronal nitric oxide synthase (nNOS) and CGRP was explored....... Immunohistochemistry of PACAP and CGRP showed co-expression in TG and TNC. PACAP and nNOS were co-localized in TG, but not in TNC. PACAP was found to co-localize with glutamine synthetase in TG satellite glial cells. CONCLUSION: PACAP-38 cause release of CGRP from TNC but not from TG. We suggest that the release...

  8. Synovial chondromatosis of the right side temporomandibular joint extending to the middle cranial fossa: A case report with 7-year postoperative follow up and expression of a biomarker of cell proliferative activity

    Science.gov (United States)

    Yoshitake, Hiroyuki; Kayamori, Kou; Wake, So; Sato, Fumiaki; Kino, Koji; Harada, Kiyoshi

    2016-01-01

    Introduction Synovial chondromatosis of the temporomandibular joint (TMJ) with cranial extension is rare. Here, we report 7-year follow-up of a case with immunohistochemical examination of cell proliferative activity. Presentation of case The patient was a 72-year-old man. Severe bone resorption of the glenoid fossa was apparent on CT images. Pathological findings by biopsy led to diagnosis of synovial chondromatosis of the right side TMJ. Extirpation of the tumor was performed via temporopreauricular incision under general anesthesia. PCNA expression was examined by immunohistochemical analysis. The lesion had penetrated into the middle cranial fossa, but the cranial dura mater was intact. Expression of PCNA was confirmed. Discussion The PCNA expression suggested that growth activity caused expansion of the lesion to the skull base. Conclusion We were able to follow up this case for a long period without recurrence postoperatively. PMID:26855075

  9. A schwannoma of the S1 dural sleeve was resected while the intact nerve fibers were preserved using a microscope. Report of a case with early MRI findings.

    Science.gov (United States)

    Kobayashi, S; Uchida, K; Kokubo, Y; Yayama, T; Nakajima, H; Inukai, T; Nomura, E; Baba, H

    2007-04-01

    In this report, we describe a small schwannoma of the dural sleeve and mention that it is often difficult to differentiate this tumor from lumbar disc herniation, especially a sequestered hernia, or a discal cyst. Gadolinium-enhanced MR images were a useful preoperative examination modality for differentiating this lesion from other diseases. Microscopically, the intradural tumor was successfully removed. The dura mater of the S1 nerve root was opened microsurgically, allowing the nerve fibers involved in the tumor to be identified. The involved fibers were cut around the tumor, and the lesion was resected while the intact nerve fibers were preserved. Based on histological examination of the resected specimen, the tumor was diagnosed as a schwannoma with multilocular cystic degeneration. Microsurgery allowed the tumor to be removed with minimal impairment from cutting of nerve fibers in the nerve root.

  10. [Extradural spinal meningioma: case report].

    Science.gov (United States)

    Dagain, A; Dulou, R; Lahutte, M; Dutertre, G; Pouit, B; Delmas, J-M; Camparo, P; Pernot, P

    2009-12-01

    We report a case of purely extradural spinal meningioma and discuss the potential pitfalls in differential diagnosis. Spinal meningiomas account for 20-30% of all spinal neoplasms. Epidural meningiomas are infrequent intraspinal tumors that can be easily confused with malignant neoplasms or spinal schwannomas. A 62-year-old man with a previous history of malignant disease presented with back pain and weakness of the lower limbs. Magnetic resonance imaging revealed a well-enhanced T4 intraspinal lesion. The intraoperative histological examination showed a meningioma (confirmed by postoperative examination). Opening the dura mater confirmed the purely epidural location of the lesion. The postoperative course was uneventful with no recurrence 12 months after surgery. Purely extradural spinal meningiomas can mimic metastatic tumors or schwannomas. Intraoperative histology is mandatory for optimal surgical decision making.

  11. [An operated case of a meningioma causing acute subdural hematoma].

    Science.gov (United States)

    Chonan, Masashi; Niizuma, Kuniyasu; Koyama, Shinya; Kon, Hiroyuki; Sannohe, Seiya; Kurotaki, Hidekachi; Midorikawa, Hiroshi; Sasaki, Tatsuya; Nishijima, Michiharu

    2013-03-01

    We report a rare case of a meningioma causing acute hematoma. A 67-year-old woman presented with sudden headache. No evidence of trauma was seen. CT demonstrated a subdural hematoma in the convexity of the fronto-temporal lobe. Magnetic resonance imaging showed marked signal heterogeneity in the convexity of the frontal lobe. One week later, the patient underwent hematoma evacuation and tumor resection including the attached dura mater. The histological diagnosis was meningothelial meningioma. The clot was connected directly to the tumor and the origin of the subdural hematoma was identified as the meningioma. Postoperative course was uneventful, and the headache improved. Meningiomas have a relatively benign course but rarely present with hemorrhage. Surgical exploration is the effective and recommended treatment.

  12. Treatment experience of surgical repair for long-term skull defect

    Directory of Open Access Journals (Sweden)

    Shou-cheng FAN

    2015-12-01

    Full Text Available Retrospective analysis was performed on 30 patients of skull defect who underwent surgical repair. Intraoperative and postoperative curative effect was evaluated on those patients, and the results showed that the incidence rate of intraoperative dura mater defect (P = 0.001, early postoperative complications [new epilepsy (P = 0.035 and effusion (P = 0.021] and late postoperative complications [foreign body sensation (P = 0.035 and dizziness and headache (P = 0.050] in long-term skull defect group were all higher than those in control group. In conclusion, surgical repair of long-term skull defect incurring high risk and various complications will not be an ideal management. Therefore, early surgical treatment for skull defect is suggested. DOI: 10.3969/j.issn.1672-6731.2015.12.016

  13. Penetrating injury of orbital roof and brain sparing the eye ball in a pediatric patient: A rare occurrence

    Directory of Open Access Journals (Sweden)

    Vikul Kumar

    2016-01-01

    Full Text Available Blowout fractures are a common occurrence in traumatic brain injury patients. In pediatric age group, orbital floor fracture is a common occurrence. We report a case of 2-year-old male admitted to trauma center, with penetrating injury to the left eye by the clutch of motorbike which fell on the child. Noncontrast computed tomography scan revealed fracture of the roof of left orbit with left frontal contusion sparing the left eyeball. There was also the continuous leak of brain matter from the left eye which suggested tear of dura mater. Urgent left frontal craniotomy was done with the evacuation of contusion, reconstruction of orbital roof, and duroplasty under general anesthesia.

  14. Multiorgan gadolinium (Gd) deposition and fibrosis in a patient with nephrogenic systemic fibrosis--an autopsy-based review

    DEFF Research Database (Denmark)

    Sanyal, Soma; Marckmann, Peter; Scherer, Susanne

    2011-01-01

    tissues of NSF patients, predominantly at the bulk chemical level. The distribution of Gd at the histologic level of organs other than skin has not been reported previously. METHODS: We analysed tissues from an autopsy case with verified advanced NSF by light microscopy and scanning electron microscopy......), kidney, lymph node, skeletal muscle, dura mater and cerebellum of the NSF autopsy case, primarily in vascular walls. Some, but not all, Gd deposits were seen in fibrotic areas. Literature review highlighted that non-specific tissue fibrosis and calcification are frequent findings in tissues of patients....../energy-dispersive X-ray spectroscopy. Furthermore, we reviewed published literature to compare the histological and histochemical findings in NSF patients and chronic renal failure (CRF) patients without NSF. RESULTS: Insoluble Gd-phosphate deposits were detected in the skin, liver, lungs, intestinal wall (ileum...

  15. Hemangioma of the porus acusticus. Impact of imaging studies: case reports

    Energy Technology Data Exchange (ETDEWEB)

    Petit-Lacour, M.C.; Marsot-Dupuch, K.; Hadj-Rabia, M.; Doyon, D.; Lasjaunias, P. [Dept. of Neuroradiology, Kremlin-Bicetre Hospital (France); Sterkers, O. [Dept. of Oto-rhino-laryngology, Beaujon Hospital, Clichy (France); Bobin, S. [Dept. of Oto-rhino-laryngology, Kremlin-Bicetre Hospital (France)

    2001-12-01

    Hemangiomas are tumors. Hemangiomas near the geniculate ganglion or in the internal acoustic meatus are well known but rare. We present two cases of hemangiomas located at the porus acusticus, an even more rare site. MRI showed a millimeter-sized tumor, located in the porus acusticus, developing perpendicular to the axis of the acoustico-facial nerves, surrounding them. They were hyperintense on T1-weighted images, strongly hyperintense on T2-weighted images with a characteristic progressive and marked enhancement after injection of gadolinium DTPA. Similar signal abnormalities were present in the adjacent temporal bone, and CT scan demonstrated a honeycomb appearance with intra-tumoral bony spicules. These imaging criteria allows differentiation between hemangioma and neurinoma. We hypothesize that this location is related to the presence of a rich vascular plexus of the dura mater in this area. (orig.)

  16. Collagenous Tissues upon Lithium Treatment: A Quantitative Ultrastructural Study

    Directory of Open Access Journals (Sweden)

    Margaret Tzaphlidou

    2004-01-01

    Full Text Available In this review, the influence of lithium treatment in mouse, rat, and rabbit skin, liver, bone, and aorta, as well as arachnoid and dura mater collagen fibrils, is examined using electron microscopy and image processing. Structural changes (fibril architecture and diameter are detected at the ultrastructural level in specimens from all lithium-treated tissues. The overall collagen fibril architecture is disturbed as compared with specimens from normal species. The mean diameter values of treated collagen fibrils are significantly smaller than those from controls in all tissues examined. The banding patterns of fibrils are normal in all cases. Measurements by a computerized method of measuring axial periodicity of fibrils indicate no effect of lithium on this parameter. Computer analysis shows no differences in charged amino acid composition between lithium-treated and -untreated samples. Under the present experimental conditions, lithium can induce permanent structural collagen alterations.

  17. Multiple Dural Tuberculomas Presenting as Leptomeningeal Carcinomatosis

    Directory of Open Access Journals (Sweden)

    Hasan Kocaeli

    2011-01-01

    Full Text Available Objective and Importance. We present the rare occurrence of multiple dural-based tuberculomas mimicking leptomeningeal carcinomatosis in a young immunocompetent patient. Clinical Presentation. A 36-year-old man presented with a 2-month history of generalized epileptic activity and altered perception. Neurological examination was remarkable for bilateral Babinski's sign. Cranial magnetic resonance imaging (MRI revealed multiple dural-based enhancing lesions with cerebral edema. Intervention. A right frontal craniotomy was performed for diagnosis. Histological examination revealed multiple confluent necrotizing and nonnecrotizing granulomas with giant cells which was consistent with tuberculosis (TB, and the patient was placed on anti-TB therapy for 24 months. Conclusion. To the best of our knowledge isolated diffuse involvement of the dura mater by TB, mimicking leptomeningeal carcinomatosis, as the sole manifestation of disease has not been reported before. Since pachymeningeal TB is rarely suspected when atypical radiological appearance is combined with the absence of systemic disease, biopsy is inevitably required for diagnosis.

  18. [Marfan syndrome and related connective tissue disorders].

    Science.gov (United States)

    Steindl, Katharina

    2013-11-27

    Marfan syndrome is an autosomal dominantly inherited connective tissue disorder with a prevalence of approximately 1:5000 people. Typical manifestations affect the cardiovascular system, eyes, skeleton, lungs, skin and dura mater. Most patients have a so-called marfanoid habitus with tall stature, long and narrow limbs, a long and narrow head shape and other skeletal abnormalities. Of particular medical importance are the possible complications such as severe scoliosis or pectus excavatum, spontaneous pneumothorax, retinal detachment, or an acute glaucoma evoked by lens luxation. However, the most dangerous complication is acute dissection of the ascending aorta, which is usually the result of a slowly progressive aortic dilatation. With the introduction of therapies the average life expectancy of previously just 32 years could be raised to above 60 years.

  19. A woman with forearm amyotrophy.

    Science.gov (United States)

    Sagui, Emmanuel; Correa, Eléonore; Ricobono, Diane; Bregigeon, Michel; Brosset, Christian

    2009-01-01

    We present the case of a 33-year-old woman with benign sporadic monomelic amyotrophy of the distal part of the arm, called Hirayama disease. Clinical features included forearm amyotrophy sparing the brachioradialis muscle, cold paresis and causalgia. Neck magnetic resonance imaging was normal in neutral and flexion position. Electromyography showed denervated patterns in the extensor digitorum communis, and conduction studies ruled out multifocal motor neuropathy. Motor evoked potentials were normal. Serum IgG anti-GM1 antibodies were moderately raised but were negative 8 months later. Outcome was favourable within 15 months, with partial motor recovery. Pathogenesis remains controversial: neck flexion induced myelopathy via chronic anterior horn ischaemia due to forward displacement of the posterior wall of the dura mater, or benign variant of lower motor neuron disease? Whatever the pathomechanism is, the clinical features and outcome are the same.

  20. A Portuguese case of Hirayama disease.

    Science.gov (United States)

    Correia de Sá, Mário; Costa, Henrique; Castro, Sérgio; Vila Real, Marta

    2013-10-28

    Hirayama disease, also known as monomelic amyotrophy or juvenile spinal muscular atrophy of the distal upper extremity features the impairment of the anterior horn cells of the distal cervical spinal cord secondary to dural sac anterior displacement during cervical flexion. We describe a case of a 17-year-old boy with a history of scoliosis, evaluated in the emergency department for decreased muscle strength and atrophy of the left upper limb with progressive worsening for about 6 months. We performed electrophysiological studies that showed severe neurogenic atrophy involving the C7-T1 left myotomes. Brain and spine MRI performed showed flattening of the lower cervical cord and dura mater anterior displacement during cervical flexion. These findings were consistent with the diagnosis of Hirayama disease.

  1. Hirayama Disease: Escaping From the Quotidian Imaging.

    Science.gov (United States)

    Agarwal, Arjit; Chandak, Shruti; Joon, Pawan

    2015-08-01

    Hirayama disease is a rare type of neurological disease commonly manifesting as brachial monomelic amyotrophy in young males of Asian origin, easily understood as juvenile non-progressive cervical amyotrophy. The first case was reported by Hirayama in 1959. The pathogenesis is attributed towards chronic compression of cervical spinal cord during flexion movements of neck in cases where there is detachment of posterior dura mater. This chronic event, invariably leads to features of cord atrophy along with other MRI features. We report a case of 21-year-old male who presented with atrophy of distal muscles of his right hand and was sent for MRI of cervical spine which revealed prominent posterior epidural venous plexus without significant cord atrophy. Clinico-radiologic profile of the patient leads toward the diagnosis of Hirayama disease which was considered as borderline because of asymmetrical cord atrophy which is a not a routine imaging feature of the entity.

  2. Seven years of recording from monkey cortex with a chronically implanted multiple microelectrode

    Directory of Open Access Journals (Sweden)

    Jürgen Krüger

    2010-05-01

    Full Text Available A brush of 64 microwires was chronically implanted in the ventral premotor cortex of a macaque monkey. Contrary to common approaches, the wires were inserted from the white matter side. This approach, by avoiding mechanical pressure on the dura and pia mater during penetration, disturbed only minimally the cortical recording site. With this approach isolated potentials and multiunit activity were recorded for more than seven years in about one third of electrodes. The indirect insertion method also provided an excellent stability within each recording session, and in some cases even allowed recording from the same neurons for several years. Histological examination of the implanted brain region shows only a very marginal damage the recording area. Advantages and problems related to long-term recording are discussed.

  3. An autopsy case of traumatic sinus thrombosis.

    Science.gov (United States)

    Seto, Y; Takeichi, S

    1996-02-01

    A 38-year-old male slipped accidentally and fell from a height of 4.6 m, and was admitted to a hospital. A radiograph indicated a linear fracture of the parietal bone across the sagittal sutura, and a computed tomography scan of the head showed severe subdural hematoma on both parietal sides, so an operation was performed to remove the hematoma. Five hours after the operation, brain death due to a cerebral herniation occurred, and he died six days later. Autopsy revealed a linear fracture of the parietal bones, which crossed obliquely the sagittal sutura. A slightly lacerated wound of the dura mater was seen on the sagittal sutura, from where the latter half of that point to the left and right transverse sinuses were occluded completely with thrombosis. The brain was markedly swollen. From these findings, the victim was considered to have died from acute cerebral swelling due to traumatic thrombosis of the superior sagittal sinus.

  4. Effect research of the hydroxyapatite orbital implant on orbital development in children%儿童羟基磷灰石眼座眶内植入对眼眶发育的影响研究

    Institute of Scientific and Technical Information of China (English)

    宋斗; 高方; 苏书; 孙桂珍

    2002-01-01

    Objective To evaluate the clinical effect of a surgical procedure to reconstruct socket with hydroxyapatite in the anophthalmic children. Method Hydroxyapatite was wrapped up with scleral or dura mater shell as a orbital implant. 53 consecutive patients were involved, 34 of whom had been referred for primary implantation surgery, and 19 for secondary implantation surgery. 3 patients had been drilled. Result There were no cases of orbital infection, implant extrusion, implant exposure or migration in 1~ 76 months of follow up. All children achieved a better facial appearance. The children who undergone drilling and peg placement had excellent prosthesis motility, on the contrary the effect was not very good. Conclusion The hydroxyapatite orbital implant give good cosmetic results with a low rate of complications, promotes orbital development, and helps to children's normal body and mind growth.

  5. Multi-focus Image Fusion Using Epifluorescence Microscopy for Robust Vascular Segmentation

    Science.gov (United States)

    Pelapur, Rengarajan; Prasath, V. B. Surya; Bunyak, Filiz; Glinskii, Olga V.; Glinsky, Vladislav V.; Huxley, Virginia H.; Palaniappan, Kannappan

    2015-01-01

    Automatic segmentation of three-dimensional microvascular structures is needed for quantifying morphological changes to blood vessels during development, disease and treatment processes. Single focus two-dimensional epifluorescent imagery lead to unsatisfactory segmentations due to multiple out of focus vessel regions that have blurred edge structures and lack of detail. Additional segmentation challenges include varying contrast levels due to diffusivity of the lectin stain, leakage out of vessels and fine morphological vessel structure. We propose an approach for vessel segmentation that combines multi-focus image fusion with robust adaptive filtering. The robust adaptive filtering scheme handles noise without destroying small structures, while multi-focus image fusion considerably improves segmentation quality by deblurring out-of-focus regions through incorporating 3D structure information from multiple focus steps. Experiments using epifluorescence images of mice dura mater show an average of 30.4% improvement compared to single focus microvasculature segmentation. PMID:25571050

  6. Multiquadric Spline-Based Interactive Segmentation of Vascular Networks.

    Science.gov (United States)

    Meena, Sachin; Surya Prasath, V B; Kassim, Yasmin M; Maude, Richard J; Glinskii, Olga V; Glinsky, Vladislav V; Huxley, Virginia H; Palaniappan, Kannappan

    2016-08-01

    Commonly used drawing tools for interactive image segmentation and labeling include active contours or boundaries, scribbles, rectangles and other shapes. Thin vessel shapes in images of vascular networks are difficult to segment using automatic or interactive methods. This paper introduces the novel use of a sparse set of user-defined seed points (supervised labels) for precisely, quickly and robustly segmenting complex biomedical images. A multiquadric spline-based binary classifier is proposed as a unique approach for interactive segmentation using as features color values and the location of seed points. Epifluorescence imagery of the dura mater microvasculature are difficult to segment for quantitative applications due to challenging tissue preparation, imaging conditions, and thin, faint structures. Experimental results based on twenty epifluorescence images is used to illustrate the benefits of using a set of seed points to obtain fast and accurate interactive segmentation compared to four interactive and automatic segmentation approaches.

  7. In vivo bioprinting for computer- and robotic-assisted medical intervention: preliminary study in mice.

    Science.gov (United States)

    Keriquel, Virginie; Guillemot, Fabien; Arnault, Isabelle; Guillotin, Bertrand; Miraux, Sylvain; Amédée, Joëlle; Fricain, Jean-Christophe; Catros, Sylvain

    2010-03-01

    We present the first attempt to apply bioprinting technologies in the perspective of computer-assisted medical interventions. A workstation dedicated to high-throughput biological laser printing has been designed. Nano-hydroxyapatite (n-HA) was printed in the mouse calvaria defect model in vivo. Critical size bone defects were performed in OF-1 male mice calvaria with a 4 mm diameter trephine. Prior to laser printing experiments, the absence of inflammation due to laser irradiation onto mice dura mater was shown by means of magnetic resonance imaging. Procedures for in vivo bioprinting and results obtained using decalcified sections and x-ray microtomography are discussed. Although heterogeneous, these preliminary results demonstrate that in vivo bioprinting is possible. Bioprinting may prove to be helpful in the future for medical robotics and computer-assisted medical interventions.

  8. Nitric oxide synthase (NOS) in the trigeminal vascular system and other brain structures related to pain in rats

    DEFF Research Database (Denmark)

    Ramachandran, Roshni; Ploug, Kenneth Beri; Hay-Schmidt, Anders;

    2010-01-01

    Nitric oxide (NO) is considered to be a key mediator in the pathophysiology of migraine but the localisation of NO synthesizing enzymes (NOS) throughout the pain pathways involved in migraine has not yet been fully investigated. We have used quantitative real-time PCR and Western blotting...... to measure the respective levels of mRNA and protein for nNOS and eNOS in peripheral and central tissues involved in migraine pain: dura mater, pial arteries, trigeminal ganglion (TG) trigeminal nucleus caudalis (TNC), periaqueductal grey (PAG), thalamus, hypothalamus, cortex, pituitary gland, hippocampus...... concentration in cortex. The same pattern of expression was also observed with the eNOS protein. In conclusion, we found both nNOS and eNOS located to areas relevant to migraine supporting the involvement of NO in migraine mechanisms....

  9. Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact

    Science.gov (United States)

    Jia, Yali; An, Lin; Wang, Ruikang K.

    2010-05-01

    We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ~10 s to complete one 3-D scan of ~2.5×2.5 mm2. The system is sensitive to blood flow with a velocity ranging from ~4 μm/s to ~23 mm/s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

  10. PRIMARY ENDOPROSTHETIC REPLACEMENT OF THE ANOPHTHALMIC ORBIT IN PATIENTS WITH UVEAL MELANOMA: SIX-YEAR FOLLOW-UP RESULTS

    Directory of Open Access Journals (Sweden)

    A. A. Yarovoy

    2012-01-01

    Full Text Available A locomotor stump was formed in 36 patients (28 women and 8 men, by implanting an endoprosthesis for enucleation of the eyeball with uveal melanoma (UM. The indication for endoprosthesis implantation was no signs of extrabulbar growth. A modified 17–19 mm silicone implant covered with strips from a dura mater graft and medical mesh fabric was used as an orbital implant. The follow-up was 3 to 72 months (mean 32.5 months. All the patients achieved a satisfactory cosmetic effect. None patient was found to have a recurrent orbital tumor. Out of the complications, anterior implant surface denudation was noted in 4 patients. Two patients developed metastases. The absence of recurrent orbital UM at a 6-year follow-up enables primary endoprosthetic replacement of the orbit for UM to be regarded as a safe and reasonable method for patient cosmetic rehabilitation. 

  11. Petrous Bone Cholesteatoma

    Science.gov (United States)

    Sanna, Mario; Zini, Carlo; Gamoletti, Roberto; Frau, Niccolò; Taibah, Abdel Kader; Russo, Alessandra; Pasanisi, Enrico

    1993-01-01

    Petrous bone cholesteatoma is a rare pathologic entity and may be a difficult surgical challenge because of potential involvement of the facial nerve, carotid artery, dura mater, otic capsule, and risk of cerebrospinal fluid leak. The objective of this article is to present a personal classification of petrous bone cholesteatomas, a survey of recent surgical attitudes, and our present surgical strategy based on our experience with 54 operations between 1978 and 1990. Radical petromastoid exenteration with marsupialization and the middle cranial fossa approach were used only for small pure infra- or supralabyrinthine cholesteatomas, respectively. The enlarged transcochlear approach with closure of the external auditory canal was used for infralabyrinthine, infralabyrinthine-apical, and massive petrous bone cholesteatomas. Five cases with petrous bone cholesteatomas in different locations are described in detail to present the signs and symptoms together with the management. ImagesFigure 10Figure 11Figure 12Figure 13Figure 14Figure 15Figure 16Figure 17Figure 18 PMID:17170912

  12. Gene Expression in the Human Endolymphatic Sac

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Kirkeby, Svend; Vikeså, Jonas

    2015-01-01

    OBJECTIVES/HYPOTHESIS: The purpose of the present study is to explore, demonstrate, and describe the expression of genes related to the solute carrier (SLC) molecules of ion transporters in the human endolymphatic sac. STUDY DESIGN: cDNA microarrays and immunohistochemistry were used for analyses...... of fresh human endolymphatic sac tissue samples. METHODS: Twelve tissue samples of the human endolymphatic sac were obtained during translabyrinthine surgery for vestibular schwannoma. Microarray technology was used to investigate tissue sample expression of solute carrier family genes, using adjacent dura...... mater as control. Immunohistochemistry was used for verification of translation of selected genes, as well as localization of the specific protein within the sac. RESULTS: An extensive representation of the SLC family genes were upregulated in the human endolymphatic sac, including SLC26a4 Pendrin, SLC4...

  13. Hand-held multi-DOF robotic forceps for neurosurgery designed for dexterous manipulation in deep and narrow space.

    Science.gov (United States)

    Okubo, Takuro; Harada, Kanako; Fujii, Masahiro; Tanaka, Shinichi; Ishimaru, Tetsuya; Iwanaka, Tadashi; Nakatomi, Hirohumi; Sora, Sigeo; Morita, Akio; Sugita, Naohiko; Mitsuishi, Mamoru

    2014-01-01

    Neurosurgical procedures require precise and dexterous manipulation of a surgical suture in narrow and deep spaces in the brain. This is necessary for surgical tasks such as the anastomosis of microscopic blood vessels and dura mater suturing. A hand-held multi-degree of freedom (DOF) robotic forceps was developed to aid the performance of such difficult tasks. The diameter of the developed robotic forceps is 3.5 mm, and its tip has three DOFs, namely, bending, rotation, and grip. Experimental results showed that the robotic forceps had an average needle insertion force of 1.7 N. Therefore, an increase in the needle insertion force is necessary for practical application of the developed device.

  14. Dural metastases from prostate carcinoma: A systematic review of the literature apropos of six patients

    Energy Technology Data Exchange (ETDEWEB)

    Vasconcelos Sobreira Guedes, Bruno de, E-mail: b_guedes@hotmail.com [Santa Casa de Misericordia de Sao Paulo - Servico de Diagnostico por Imagem, Rua Dr. Cesario Motta Junior 112, Vila Buarque, Sao Paulo CEP 01221-020, SP (Brazil); Rocha, Antonio Jose da, E-mail: antonio.rocha@uol.com.br [Santa Casa de Misericordia de Sao Paulo - Servico de Diagnostico por Imagem, Rua Dr. Cesario Motta Junior 112, Vila Buarque, Sao Paulo CEP 01221-020, SP (Brazil); Pereira Pinto Gama, Hugo, E-mail: hugo.gama@fleury.com.br [Santa Casa de Misericordia de Sao Paulo - Servico de Diagnostico por Imagem, Rua Dr. Cesario Motta Junior 112, Vila Buarque, Sao Paulo CEP 01221-020, SP (Brazil); Silva, Carlos Jorge da, E-mail: carlos.silva@fleury.com.br [Santa Casa de Misericordia de Sao Paulo - Servico de Diagnostico por Imagem, Rua Dr. Cesario Motta Junior 112, Vila Buarque, Sao Paulo CEP 01221-020, SP (Brazil)

    2011-11-15

    Intracranial metastases are a rare manifestation of prostate carcinoma and the dura mater is the most affected site. We report a series of six patients with dural prostate metastases (DPM) and perform a systematic review of the current literature in order to depict imaging trademarks of this condition. This review points to a magnetic resonance imaging (MRI) pattern of meningeal involvement characterized by a diffuse smooth thickening, nodular appearance or dural-based masses. We also demonstrate an osteoblastic pattern of lesions, particularly in sphenoid wing, by computed tomography (CT) scans. We suggest that these imaging findings may support an elevated index of suspicion of DPM in elderly men, including those patients without urologic symptoms.

  15. A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with hypertrophic pachymeningitis.

    Science.gov (United States)

    Shiraishi, Wataru; Hayashi, Shintaro; Iwanaga, Yasutaka; Murai, Hiroyuki; Yamamoto, Akifumi; Kira, Jun-ichi

    2015-02-15

    A 43-year-old woman with a 3-year history of headache, fever, and swelling of the forehead, presented to our hospital. A general examination revealed palmar and plantar pustules. Blood analyses showed an elevated white blood cell count, C-reactive protein level, and erythrocyte sedimentation rate. Brain MRI revealed a partially thickened cranial bone with gadolinium enhancement, and also abnormally enhanced dura mater. Bone scintigraphy showed involvement of the cranial bone and bilateral sternoclavicular joints. Palmar skin biopsy indicated palmoplantar pustulosis. From these results, SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome with associated hypertrophic pachymeningitis was diagnosed. After corticosteroid therapy and tonsillectomy, the clinical symptoms and radiological abnormalities were improved. Clinicians should be aware of SAPHO as a potential unusual cause of hypertrophic pachymeningitis.

  16. New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H3 receptors.

    Science.gov (United States)

    Göthert, M; Garbarg, M; Hey, J A; Schlicker, E; Schwartz, J C; Levi, R

    1995-05-01

    As a result of intensive research during several decades, the distribution, function, and pathophysiological role of cardiovascular H1 and H2 receptors are well known, whereas reports on the occurrence and function of H3 receptors in blood vessels and the heart have not become available before the last 7 years (i.e., 4 years after the first description of these receptors in the central nervous system in 1983). The development of selective and potent H3 receptor agonists and antagonists was a prerequisite for convenient investigations of cardiovascular H3 receptors, which like H1 and H2 receptors are G-protein coupled but unlike them have not yet been cloned. Both in blood vessels and the heart, H3 receptors are located on noradrenergic nerve endings and upon stimulation mediate an inhibition of noradrenaline release. Whereas it remains to be clarified under which conditions the vascular H3 receptors may be stimulated by endogenous histamine, those in the heart become activated in the early phases of myocardial ischemia characterized by an increased histamine spillover. The H3 receptors in the central nervous system also appear to be of importance for the control of vascular function. Inhibitory presynaptic H3 receptors occur on trigeminal sensory C fibres supplying blood vessels in the dura mater. Release of neuropeptides from these fibres induces a neurogenic inflammation, which has been suggested to be involved in the pathogenesis of migraine. An interaction, involving presynaptic H3 receptors, between sensory C fibres and mast cells in close apposition to these fibres plays a role in the control of histamine synthesis in the dura mater.(ABSTRACT TRUNCATED AT 250 WORDS)

  17. Dynamics of the spinal cord: An analysis of functional myelography by CT scan

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Y.; Suzuki, K.; Ohmori, K.

    1988-12-01

    The antero-posterior movement of the spinal cord with flexion and extension of the neck was analyzed in order to clarify the mechanism of spinal cord compression in cases with postoperative spinal deformity, and to contribute to the improvement of the surgical methods of conventional laminectomy. The control subjects were 47 cases without cervico-thoracic neurological symptoms, who underwent CT myelography in flexion and extension of the neck; the cervical spinal cord was examined in 27 of these cases and the thoracic cord in the other 20. CT myelography was also carried out in 16 patients with cervical myelopathy and in 5 patients after posterior decompression surgery (suspension laminotomy). CT sections in flexion and extension of the neck were analyzed for (1) change of configuration of the dura mater and the spinal cord, and (2) antero-posterior shift of the spinal cord in the subarachnoid space. In the control subjects, the configuration of the dura mater was slightly flattened at C5/6, C6 and C6/7 in extension of the neck. The cervical spinal cord shifted anteriorly in flexion and posteriorly in extension of the neck, and was flattened at the midcervical level in flexion in the control subjects. There was a statistically significant correlation between the location of the spinal cord and the adjacent intervertebral angles at the levels of C4, C5 and C6. These results were compared with the results from the 16 patients with cervical myelopathy and 5 patients after suspension laminotomy. The thoracic spinal cord shifted anteriorly in neck flexion and posteriorly in extension, especially at upper thoracic level. In order to avoid spinal cord compression due to anterior shift of the spinal cord caused by postoperative kyphosis, it is necessary to employ the surgical method which can prevent postoperative kyphotic deformity.

  18. Nanofiber nets in prevention of cicatrization in spinal procedures. Experimental study.

    Science.gov (United States)

    Andrychowski, Jarosław; Frontczak-Baniewicz, Małgorzata; Sulejczak, Dorota; Kowalczyk, Tomasz; Chmielewski, Tomasz; Czernicki, Zbigniew; Kowalewski, Tomasz Aleksander

    2013-01-01

    Excessive cicatrisation or epidural fibrosis in the operative field is an inappropriate event occasionally occurring after neurosurgical procedures (i.e., spine procedures and craniotomies). This excessive process may disturb the postoperative course and render reoperations more difficult and risky. The literature describes this phenomenon as accompanying up to 20% of neurosurgical procedures. The scar tissue that forms postoperatively adheres to the dura mater, penetrates into the spinal canal and can cause narrowing symptoms, neurological deficits and pain. The incidence and spread of this excessive scar or epidural fibrosis can be prevented through the modification of the surgical technique by incorporating endoscopic or microscopic access to minimize the operative field and the use of isolating substances (autogenous or heterogeneous) administered intraoperatively. The aim of this experimental study was to morphologically assess the cicatrization process, adhesion and to prevent excessive scar formation with the local use of membranes manufactured by an electrospinning process (nanotechnology). We also investigated whether the biodegradable nanofibrous net triggers or modifies the immunological response or the local inflammatory process. Micro-nanofibrous membranes were produced by the electrospinning process. A biodegradable, medically certified copolymer poly(L-lactide-co-caprolactone) (PLCL) was used as the electrospun material. An experimental rat model was used in this study. Experimental and control groups were formed with specified follow-up times of 4, 14 and 30 days. During the operation, a two-level laminectomy in the thoracic segment was performed. The operative field was divided into two regions. Isolating material was used on the dura mater and surface of the spinal cord in the area where the laminectomy was performed. The material was analysed with the use of light and electron microscopy. Local cicatrisation can be modified using nanomaterials

  19. Fully endoscopic supraorbital keyhole approach to the anterior cranial base: A cadaveric study

    Directory of Open Access Journals (Sweden)

    Mehmet Osman Akçakaya

    2015-01-01

    Full Text Available Introduction: The supraorbital keyhole approach for anterior cranial base lesions has been increasingly used in clinical practice. Anatomical studies focusing on the endoscopic anatomy via this approach are few, although the microscopic anatomy has been well studied. The aim of this study is to describe the anatomical features and surgical exposure provided by the endoscopic supraorbital keyhole approach using quantitative measurements. Materials and Methods: Nine formalin-fixed human cadavers from the inventory of the Anatomy department were used. A total of 18 supraorbital keyhole cranitomies were conducted. The distances between the target anatomical structures and the dura mater at the craniotomy site, and the distances between deep anatomical structures were measured with purpose-designed hooks. Results: The distance between the dura mater and optic canal was measured as 69.5 ± 6.7 mm (62-83 mm; optic chiasm as 76.2 ± 5.4 mm (67-86 mm; anterior communicating artery as 82.6 ± 6.1 mm (71-93 mm; internal carotid artery (ICA bifurcation as 74.7 ± 6.0 mm (66-84 mm and the basilar tip as 94.9 ± 7.0 mm (87-111 mm. The mean diameter of the optic canal was 7.4 ± 1.3 mm (6-11 mm, whereas the mean diameter of diaphragma sellae was measured as 8.4 ± 1.1 mm (7-10 mm. Conclusions: The results of this study showed that the anterior anda medial aspects of the anterior cranial fossa can be visualized properly. Dissection of the ipsilateral arteries of Circle of Willis can be performed easily using an endoscopic supraorbital keyhole approach.

  20. Two cases of thoracic spinal anaesthesia in patients with severe diseases

    Directory of Open Access Journals (Sweden)

    Adriano Bechara de Souza Hobaika

    2015-07-01

    Full Text Available This manuscript describes two cases of thoracic spinal anaesthesia for patients with severe diseases, with satisfying results. Patient 1: female, 57 years old, submitted to a surgical gastrostomy. She had squamous cell carcinoma of the hypopharynx involving the C6 vertebra, carotid and thyroid, with a fistula in the cervical region. After sedation, an epidural puncture was performed in the T7–T8 interspace and an epidural catheter was introduced. Then, a 25G Quinke needle was introduced 5.4 cm in the subarachnoid T8–T9 interspace and 5.0 mg of isobaric bupivacaine was administered. The dermatome level of anaesthesia was established from T3 to T12, preserving the movement of lower limbs. Patient 2: male, 41 years old, with alcohol-related brain atrophy, progressive strength loss in both lower and upper limbs, with spastic tetraparesis and tetrahyperreflexia. After sedation, a 25G Quinke needle was introduced in the subarachnoid T8–T9 interspace, and 5.0 mg of isobaric bupivacaine was introduced. Both patients were transferred to the post-anaesthesia recovery room. The greatest cause for concern in the administration of spinal anaesthesia is the possibility of an accidental medullary puncture. In a recent study, it was found a larger distance between the dura mater and the spinal cord in T6. In another study, the largest distance between the dura mater and the spinal cord was found in T5. Thoracic spinal anaesthesia technique is another anaesthetic technique that may be used in some special situations.

  1. Photovoltaics: Highly Efficient Hybrid Photovoltaics Based on Hyperbranched Three-Dimensional TiO 2 Electron Transporting Materials (Adv. Mater. 18/2015)

    KAUST Repository

    Mahmood, Khalid

    2015-05-01

    Solution-processed hybrid photovoltaics are a potentially disruptive third-generation solar cell technology. On page 2859, A. Amassian and co-workers demonstrate that an electrospun hyperbranched electron-transporting material is capable of achieving highly efficient hybrid solar cells across different platforms, including lead-halide perovskites (15.5%) and dye-sensitized solar cells (11.2%).

  2. Review of corrosion behavior of ceramic heat exchanger materals: Corrosion characteristics of silicon carbide and silicon nitride. Final report, September 11, 1992--March 11, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Munro, R.G.; Dapkunas, S.J.

    1993-09-01

    The present work is a review of the substantial effort that has been made to measure and understand the effects of corrosion with respect to the properties, performance, and durability of various forms of silicon carbide and silicon nitride. The review encompasses corrosion in diverse environments, usually at temperatures of 1000C or higher. The environments include dry and moist oxygen, mixtures of hot gaseous vapors, molten salts, molten metals, and complex environments pertaining to coal ashes and slags.

  3. Cellular Microcultures: Programming Mechanical and Physicochemical Properties of 3D Hydrogel Cellular Microcultures via Direct Ink Writing (Adv. Healthcare Mater. 9/2016).

    Science.gov (United States)

    McCracken, Joselle M; Badea, Adina; Kandel, Mikhail E; Gladman, A Sydney; Wetzel, David J; Popescu, Gabriel; Lewis, Jennifer A; Nuzzo, Ralph G

    2016-05-01

    R. Nuzzo and co-workers show on page 1025 how compositional differences in hydrogels are used to tune their cellular compliance by controlling their polymer mesh properties and subsequent uptake of the protein poly-l-lysine (green spheres in circled inset). The cover image shows pyramid micro-scaffolds prepared using direct ink writing (DIW) that differentially direct fibroblast and preosteoblast growth in 3D, depending on cell motility and surface treatment.

  4. From channel-forming ionic liquid crystals exhibiting humidity-induced phase transitions to nanostructured ion-conducting polymer membranes (adv. Mater. 26/2013).

    Science.gov (United States)

    Zhang, Heng; Li, Lei; Möller, Martin; Zhu, Xiaomin; Rueda, Jaime J Hernandez; Rosenthal, Martin; Ivanov, Dimitri A

    2013-07-12

    A novel wedge-shaped amphiphilic molecule bearing a sulfonate group at the tip displays humidity-induced phase transitions from a hexagonal columnar structure to a bicontinuous cubic phase. The mesophases can be frozen by photopolymerization of acrylic end-groups resulting in free-standing membranes with different topology of ionic nanochannels. The obtained membranes with a well-ordered ionic channel structure hold promise for applications in separation and catalysis.

  5. Photoacoustic Imaging: Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH (Adv. Mater. 19/2016).

    Science.gov (United States)

    Miao, Qingqing; Lyu, Yan; Ding, Dan; Pu, Kanyi

    2016-05-01

    Despite the great potential of photoacoustic imaging in the life sciences, the development of smart activatable photoacoustic probes remains elusive. On page 3662, K. Pu and co-workers report a facile nanoengineering approach based on semiconducting oligomer nano-particles to develop ratiometric photoacoustic probes with amplified brightness and enhanced sensing capability for accurate photoacoustic mapping of pH in the tumors of living mice.

  6. 3D Printing: 3D Printing of Conductive Complex Structures with In Situ Generation of Silver Nanoparticles (Adv. Mater. 19/2016).

    Science.gov (United States)

    Fantino, Erika; Chiappone, Annalisa; Roppolo, Ignazio; Manfredi, Diego; Bongiovanni, Roberta; Pirri, Candido Fabrizio; Calignano, Flaviana

    2016-05-01

    On page 3712, E. Fantino, A. Chiappone, and co-workers fabricate conductive 3D hybrid structures by coupling the photo-reduction of metal precursors with 3D printing technology. The generated structures consist of metal nanoparticles embedded in a polymer matrix shaped into complex multilayered architectures. 3D conductive structures are fabricated with a digital light-processing printer incorporating silver salt into photocurable formulations.

  7. Sindicatos Políticos y Economía (1972-1986) San José: Editorial Alma Mater, 1987. (Elisa Donato y Manuel Rojas)

    OpenAIRE

    Botey, Ana M

    2012-01-01

    Introducción Sindicatos, política y economía (1972-1986) es un interesante libro sobre la situación del movimiento sindical costarricense y sus perspectivas futuras. Se divide en siete capítulos: el movimiento sindical después de 1978,  el nivel de vida, características estructurales del movimiento sindical en el periodo sindical 1972-1984,  la actividad del movimiento sindical en el periodo (1972-1984),  el estado y el sindicalismo, Sindicatos, empresarios y sacerdotes. El libro muestra un e...

  8. El «Stabat Mater» glosado y traducido por sor María Gertrudis de la Cruz Hore a fines del siglo XVII

    Directory of Open Access Journals (Sweden)

    Morand, Frédérique

    2006-12-01

    Full Text Available The essay gives us new information about the most famous Gertrudis Hore’s creation, profess in the Concepcionist convent of Santa María in Cádiz, and her several editions. For the first time, we find out the fraud literary and copy of this shrewd poetess, however, at the same time, a really interesting melting between prose, poem and holy music on tightening liturgical period normally distant. In this writing, typical of Virgin literature, a continually using of feminine references do innovation form’s to this text.El artículo da a conocer esta olvidada creación y sus distintas ediciones, el mayor éxito literario de María Gertrudis Hore, religiosa Concepcionista Calzada en Cádiz. Se descubre, por vez primera, la superchería de la astuta erudita, a la vez que la interesante fusión literaria realizada entre prosa, verso y música sacra al estrechar hábilmente dos tiempos litúrgicos habitualmente distantes. En este escrito propiamente inmaculista, el uso continuo del referente femenino destaca por su novedad.

  9. Celulares: a emergência de um novo tipo de controle materno Cell phones: the emergence of a new king of materal control

    Directory of Open Access Journals (Sweden)

    Ana Maria Nicolaci-da-Costa

    2006-12-01

    Full Text Available Em uma pesquisa exploratória sobre o uso de celulares por jovens das camadas médias cariocas, entre 18 e 25 de idade, foi constatado que eles reclamavam muito que suas mães os controlavam ininterruptamente por meio de seus celulares. Para averiguar mais detalhadamente o que acontece entre mães e filhos dessa faixa etária, foi realizada uma segunda pesquisa. Nesta, foram entrevistadas 20 mães, também pertencentes às camadas médias cariocas, cujos filhos tinham perfil análogo ao dos jovens da primeira pesquisa. Para todas, a principal função dos celulares é abertamente a de controlar os filhos. Elas mostraram, no entanto, saber que há uma diferença entre o controle que vigorava quando eram jovens e aquele ao qual hoje submetem os filhos. Teorias contemporâneas sobre controle e vigilância de fato argumentam que houve uma substituição do controle normativo e coercitivo da modernidade pelo "ter conhecimento" do que se passa, característico da Era da Informação.An exploratory research on the use of cell phones by middle-class youngsters, ages 18 to 25, residing in Rio de Janeiro, revealed that they complained a great deal that their mothers controlled them unrelentingly by means of cell phones. To take a deeper look into what happens between mothers and children in this age group, a second investigation was carried out. Twenty middle-class mothers were interviewed, whose children's profile were analogous to that of the youngsters in the previous research. For all of the mothers, the main benefit of cell phones is to control their children. Nevertheless, they demonstrated to know that there's a difference between the control that they submit their children to from that that prevailed when they themselves were young. Contemporary control and surveillance theories, in fact, argue that the normative and coercive control of modernity has been replaced by "having knowledge" of what goes on, which is characteristic of the Information Era.

  10. Field-Effect Transistors: Ultrathin MXene-Micropattern-Based Field-Effect Transistor for Probing Neural Activity (Adv. Mater. 17/2016).

    Science.gov (United States)

    Xu, Bingzhe; Zhu, Minshen; Zhang, Wencong; Zhen, Xu; Pei, Zengxia; Xue, Qi; Zhi, Chunyi; Shi, Peng

    2016-05-01

    A field-effect transistor (FET) based on ultrathin Ti3 C2 -MXene micropatterns is developed by C. Zhi, P. Shi, and co-workers, as described on page 3333. The FET can be utilized for label-free probing of small molecules in typical biological environments, e.g., for fast detection of action potentials in primary neurons. This device is produced with a microcontact printing technique, harnessing the unique advantages for easy fabrication.

  11. Explosives: Metal-Organic Framework Templated Synthesis of Copper Azide as the Primary Explosive with Low Electrostatic Sensitivity and Excellent Initiation Ability (Adv. Mater. 28/2016).

    Science.gov (United States)

    Wang, Qianyou; Feng, Xiao; Wang, Shan; Song, Naimeng; Chen, Yifa; Tong, Wenchao; Han, Yuzhen; Yang, Li; Wang, Bo

    2016-07-01

    On page 5837, L. Yang, B. Wang, and co-workers describe a metal-organic framework (MOF) templating method to synthesize copper azide uniformly anchored in a 3D interconnected carbon matrix and evenly spaced by the electron-conductive joints. This strategy sheds light on the preparation of powerful yet safe primary explosives and fulfills the need for controllable explosive systems.

  12. Microfluidics-Based Biosensors: A Microfluidic Paper-Based Origami Nanobiosensor for Label-Free, Ultrasensitive Immunoassays (Adv. Healthcare Mater. 11/2016).

    Science.gov (United States)

    Li, Xiao; Liu, Xinyu

    2016-06-01

    The first microfluidic paper-based origami nano-biosensor featuring zinc oxide nanowires and an electrochemical impedance spectroscopy biosensing mechanism, for label-free, ultrasensitive immunoassays is reported by X. Li and X. Liu on page 1326. The sensor consists of cellulose paper, a carbon ink electrode, and zinc oxide nanowires directly grown on the top. Possible parallelization of assays and high storage stability render the sensor promising for clinical diagnostics applications.

  13. Intracellular Delivery: Diamond-Nanoneedle-Array-Facilitated Intracellular Delivery and the Potential Influence on Cell Physiology (Adv. Healthcare Mater. 10/2016).

    Science.gov (United States)

    Zhu, Xiaoyue; Yuen, Muk Fung; Yan, Li; Zhang, Zhenyu; Ai, Fujin; Yang, Yang; Yu, Peter K N; Zhu, Guangyu; Zhang, Wenjun; Chen, Xianfeng

    2016-05-01

    G. Zhu, W. Zhang, X. Chen, and co-workers show on page 1157 that diamond needle arrays can efficiently deliver biomolecules into living cells. The study paves the way to a wide application of the nanonneedle treatment by systematically investigating the influence of the treatment on metabolic signal pathways. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Flexible Electronics: Theoretical and Experimental Studies of Epidermal Heat Flux Sensors for Measurements of Core Body Temperature (Adv. Healthcare Mater. 1/2016).

    Science.gov (United States)

    Zhang, Yihui; Chad Webb, Richard; Luo, Hongying; Xue, Yeguang; Kurniawan, Jonas; Cho, Nam Heon; Krishnan, Siddharth; Li, Yuhang; Huang, Yonggang; Rogers, John A

    2016-01-01

    On page 119, J. A. Rogers and co-workers present theoretical approaches, modeling algorithms, materials, and device designs for the noninvasive measurement of core body temperature by using multiple differential temperature sensors that attach softly and intimately onto the surface of the skin. The image shows the construction of differential temperature sensors using thermally insulating foam as the separation material. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Conducting Membranes: Unprecedented Perovskite Oxyfluoride Membranes with High-Efficiency Oxygen Ion Transport Paths for Low-Temperature Oxygen Permeation (Adv. Mater. 18/2016).

    Science.gov (United States)

    Zhu, Jiawei; Liu, Gongping; Liu, Zhengkun; Chu, Zhenyu; Jin, Wanqin; Xu, Nanping

    2016-05-01

    Perovskite oxyfluoride (ABO3-δ Fγ ) membranes for low-temperature oxygen permeation are reported by W. Jin and co-workers. As described on page 3511, using mixed ionic and electronic conducting (MIEC) oxides, this new type of membrane outperforms current state-of-the-art MIEC membranes and satisfies commercial requirements at low temperatures (<923 K). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Phosphorescent OLEDs: Sky-Blue Phosphorescent OLEDs with 34.1% External Quantum Efficiency Using a Low Refractive Index Electron Transporting Layer (Adv. Mater. 24/2016).

    Science.gov (United States)

    Shin, Hyun; Lee, Jeong-Hwan; Moon, Chang-Ki; Huh, Jin-Suk; Sim, Bomi; Kim, Jang-Joo

    2016-06-01

    J.-J. Kim and co-workers achieve highly efficient blue organic light-emitting diodes (OLEDs) using a low-refractive-index layer. As described on page 4920, an external quantum efficiency over 34% is achieved, owing to the low refractive index of the materials. A milepost and a shining entrance of the castle are the metaphor indicating the way to highly efficient blue OLEDs. On the way to the castle, the depicted chemical structures serve as the light-emitting layer. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Photoelectrochemistry: Enhanced Photoresponse of FeS2 Films: The Role of Marcasite–Pyrite Phase Junctions  (Adv. Mater. 43/2016, Back Cover)

    NARCIS (Netherlands)

    Wu, Longfei; Dzade, N.Y.|info:eu-repo/dai/nl/41249311X; Gao, L.; Scanlon, D. O.; Öztürk, Z.; Hollingsworth, N.; Weckhuysen, B.M.|info:eu-repo/dai/nl/285484397; Hensen, E. J. M.; de Leeuw, Nora H.|info:eu-repo/dai/nl/376421061; Hofmann, J. P.

    2016-01-01

    The beneficial role of marcasite in pyrite thin films for photoelectrochemical applications is reported by J. P. Hofmann and co-workers on page 9602. A bulk heterojunction with staggered band alignment at the pyrite–marcasite interface enhances charge-carrier separation and leads to a dramatic

  18. Photoelectrochemistry: Enhanced Photoresponse of FeS2 Films: The Role of Marcasite–Pyrite Phase Junctions  (Adv. Mater. 43/2016, Back Cover)

    OpenAIRE

    Wu, Longfei; Dzade, N.Y.; Gao, L; Scanlon, D. O.; Öztürk, Z.; Hollingsworth, N.; Weckhuysen, B. M.; Hensen, E. J. M.; de Leeuw, Nora H.; Hofmann, J.P.

    2016-01-01

    The beneficial role of marcasite in pyrite thin films for photoelectrochemical applications is reported by J. P. Hofmann and co-workers on page 9602. A bulk heterojunction with staggered band alignment at the pyrite–marcasite interface enhances charge-carrier separation and leads to a dramatic increase of photocurrent in the FeS2 films.

  19. Tumor Bioimaging: Morphology-Tailoring of a Red AIEgen from Microsized Rods to Nanospheres for Tumor-Targeted Bioimaging (Adv. Mater. 16/2016).

    Science.gov (United States)

    Li, Yongsheng; Shao, Andong; Wang, Yao; Mei, Ju; Niu, Dechao; Gu, Jinlou; Shi, Ping; Zhu, Weihong; Tian, He; Shi, Jianlin

    2016-04-01

    Y. Li, W. Zhu, and co-workers develop a convenient and versatile "make-up" strategy to modulate the micro-sized rods of a near-infrared-emissive AIEgen probe integrated into nanospheres via a self-assembly encapsulation process, as presented on page 3187. The obtained nanospheres outperform microrods in terms of brightness, photostability, biocompatibility, tumor-accumulation, and targeting ability, making them perfect bioprobes for tumor-targeted bioimaging. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Transition Metal Dichalcogenides: Morphological Engineering of CVD-Grown Transition Metal Dichalcogenides for Efficient Electrochemical Hydrogen Evolution (Adv. Mater. 29/2016).

    Science.gov (United States)

    Ji, Qingqing; Zhang, Yu; Shi, Jianping; Sun, Jingyu; Zhang, Yanfeng; Liu, Zhongfan

    2016-08-01

    On page 6207, Y. Zhang, Z. Liu and co-workers describe morphologically engineered 2D-MoS2 for the facilitation of efficient hydrogen evolution reaction. Two pathways to achieve such a purpose are highlighted, either by non-equilibrium growth of MoS2 dendrites or by high-density nucleation of MoS2 nanoflakes directly on the electrode materials. Future research directions are also proposed and discussed to further enhance the efficiency of such unique catalysts. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.