WorldWideScience

Sample records for dubnium 258

  1. 40 CFR 258.17-258.19 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false 258.17-258.19 Section 258.17-258.19 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions §§ 258.17-258.19...

  2. Chemical isolation of dubnium (element 105) in fluoride media

    Energy Technology Data Exchange (ETDEWEB)

    Trubert, D.; Naour, C. le; Hussonnois, M.; Brillard, L.; Du, J.F. le [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire Radiochimie; Guzman, F.M. [ININ, Carretera Mexico-Toluca, Ocoyoacac, Estado de Mexico (Mexico); Constantinescu, O. [JINR, Dubna (Russian Federation). Flerov Lab. of Nuclear Reactions; Gasparro, J.; Barci, V.; Weiss, B.; Ardisson, G. [Nice Univ. (France). Lab. de Radiochimie

    2002-07-01

    The isotope {sup 262}Db was produced by irradiation of a {sup 248}Cm target with 106-MeV {sup 19}F ions at the 15 MV MP Tandem accelerator of Orsay (France). The reaction products were continuously and rapidly transported with a KCl aerosol helium jet system to the chemistry setup. They were dissolved in HF medium and the solution was passed through three successive ion exchange columns, allowing a continuous high level purification of Db from actinides on a first cation exchange column, the isolation of Db on an anion exchange one, and the retention of the long-lived decay products of {sup 262}Db (3.24 h-{sup 254}Fm) on a second cation exchange column. Just after the end of irradiation, the decay products were desorbed from this column, purified and {alpha}-sources were prepared on carbon foil by electrospray. In 13 effective irradiation hours, 22 events corresponding to the {alpha}-decay of {sup 254}Fm were recorded. Almost 70 atoms of {sup 262}Db, produced in the reaction {sup 248}Cm + {sup 19}F were isolated in dilute HF medium. Like its homologues/analogues Nb, Ta and Pa, dubnium forms, with fluoride ions, negatively charged complexes which are strongly retained on anion exchanger. (orig.)

  3. 40 CFR 258.12 - Wetlands.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Wetlands. 258.12 Section 258.12... SOLID WASTE LANDFILLS Location Restrictions § 258.12 Wetlands. (a) New MSWLF units and lateral expansions shall not be located in wetlands, unless the owner or operator can make the following...

  4. 49 CFR 195.258 - Valves: General.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Valves: General. 195.258 Section 195.258... PIPELINE Construction § 195.258 Valves: General. (a) Each valve must be installed in a location that is accessible to authorized employees and that is protected from damage or tampering. (b) Each submerged...

  5. 40 CFR 258.11 - Floodplains.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Floodplains. 258.11 Section 258.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.11 Floodplains. (a) Owners or operators of new...

  6. 40 CFR 258.13 - Fault areas.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Fault areas. 258.13 Section 258.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.13 Fault areas. (a) New MSWLF units and...

  7. 40 CFR 258.10 - Airport safety.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Airport safety. 258.10 Section 258.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.10 Airport safety. (a) Owners or operators of...

  8. 46 CFR 107.258 - Crane certification.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Crane certification. 107.258 Section 107.258 Shipping... CERTIFICATION Inspection and Certification § 107.258 Crane certification. (a) The Coast Guard may accept current... West 44th Street, New York, NY 10036, on the Internet at http://www.icgb.com. (b) Crane...

  9. Dicty_cDB: SLC258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC258 (Link to dictyBase) - - - Contig-U10207-1 SLC258P (Link to Original site) SLC...258F 729 SLC258Z 443 SLC258P 1172 - - Show SLC258 Library SL (Link to library) Clone ID SLC...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SL/SLC2-C/SLC258Q.Seq.d/ Representative seq. ID SLC...258P (Link to Original site) Representative DNA sequence >SLC258 (SLC258Q) /CSM/SL/SLC2-C/SLC...n*vyhssisinhslliivqslmikfkeninyivvlvmlnsi sslivvlnlvfslkvvlnqslchylqfvngniiinqkkillkqiy*lf*dqeig*tkikx ikinl

  10. 40 CFR 258.15 - Unstable areas.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Unstable areas. 258.15 Section 258.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL...) Karst terranes means areas where karst topography, with its characteristic surface and subterranean...

  11. 40 CFR 25.8 - Responsiveness summaries.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Responsiveness summaries. 25.8 Section... ACT § 25.8 Responsiveness summaries. Each agency which conducts any activities required under this part shall prepare a Responsiveness Summary at specific decision points as specified in program...

  12. 14 CFR 258.5 - Notice requirement.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Notice requirement. 258.5 Section 258.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... Official Airline Guide and comparable publications, and to computer reservations systems, these services...

  13. Yeast Interacting Proteins Database: YLR258W, YLR258W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YLR258W GSY2 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation...bait as prey (3) YLR258W GSY2 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitatio...pression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regu...LR258W Bait ORF YLR258W Bait gene name GSY2 Bait description Glycogen synthase, similar to Gsy1p; expression induced by glucose limit...ation, nitrogen starvation, heat shock, and stationary phase; activity regulated by

  14. Dicty_cDB: SLB258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB258 (Link to dictyBase) - - - Contig-U16382-1 SLB258Z (Link... to Original site) - - SLB258Z 667 - - - - Show SLB258 Library SL (Link to library) Clone ID SLB258 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB2-C/SLB258Q.Seq.d/ Representative seq. ID SLB25...8Z (Link to Original site) Representative DNA sequence >SLB258 (SLB258Q) /CSM/SL/SLB2-C/SLB258Q.Seq.d/ XXXXX....Seq.d/ 1322 0.0 SLC708 (SLC708Q) /CSM/SL/SLC7-A/SLC708Q.Seq.d/ 1322 0.0 SLB729 (SLB729Q) /CSM/SL/SLB7-B/SLB729Q.Seq.d/ 1322 0.0 SLB

  15. Cold Fusion Production and Decay of Neutron-Deficient Isotopes of Dubnium and Development of Extraction Systems for Group V Elements

    Energy Technology Data Exchange (ETDEWEB)

    Gates, Jacklyn M. [Univ. of California, Berkeley, CA (United States)

    2008-07-31

    Excitation functions for the 1n and 2n exit channels of the 208Pb(51V,xn)259-xDb reaction were measured. A maximum cross section of the 1n exit channel of 2070$+1100\\atop{-760}$ pb was measured at an excitation energy of 16.0 ± 1.8 MeV. For the 2n exit channel, a maximum cross section of 1660$+450\\atop{-370}$ pb was measured at 22.0 ± 1.8 MeV excitation energy. The 1n excitation function for the 209Bi(50Ti,n)258Db reaction was remeasured, resulting in a cross section of 5480$+1730\\atop{-1370}$ pb at an excitation energy of 16.0 ± 1.6 MeV. Differences in cross section maxima are discussed in terms of the fusion probability below the barrier. The extraction of niobium (Nb) and tantalum (Ta) from hydrochloric acid and mixed hydrochloric acid/lithium chloride media by bis(2-ethylhexyl) hydrogen phosphate (HDEHP) and bis(2-ethylhexyl) hydrogen phosphite (BEHP) was studied. The goal of the experiments was to find a system that demonstrates selectivity among the members of group five of the Periodic Table and is also suitable for the study of dubnium (Db, Z = 105). Experiments with niobium and tantalum were performed with carrier (10-6 M), carrier free (10-10 M) and trace (10-16 M) concentrations of metal using hydrochloric acid solution with concentrations ranging from 1 - 11 M. The extraction of niobium and tantalum from mixed hydrochloric acid/lithium chloride media by HDEHP and BEHP as a function of hydrogen ion (H+) concentration was also investigated. The data obtained are used as the basis to discuss the speciation of niobium and tantalum under the conditions studied and to evaluate possible extraction mechanisms. The 74Se(18O,p3n)88gNb excitation function was measured to determine the best energy for producing the 88Nb used in chemistry experiments. A maximum cross section of 495 +- 5 mb was observed at an 18O energy of 74.0 Me

  16. 40 CFR 258.50 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL... and environmental receptors; (2) Design of the MSWLF unit; (3) Age of the MSWLF unit; (4) The size of...-tion of placement of certification in operating record; § 258.54(c)(1), per-tain-ing to notification...

  17. Development of an extraction system for the separation of dubnium from rutherfordium using MIBK and HCl/HF solutions

    Energy Technology Data Exchange (ETDEWEB)

    Schumann, Dorothea; Dressler, Rugard [Paul Scherrer Institut (PSI), Villigen (Switzerland)

    2016-04-01

    A chemical separation system was developed to separate group 4 and 5 elements using extraction from HCl/HF solution into methyl-isobutyl-ketone (MIBK). The system is proposed to be applied for a confident assignment of the spontaneous fissioning radionuclide produced as decay product of element 115 either as dubnium (Db, Z = 105) or rutherfordium (Rf, Z = 104). Moreover, extraction systems are proposed allowing the investigation of chemical properties of Db in comparison to the properties of its lighter homologs Nb and Ta.

  18. 10 CFR 25.8 - Information collection requirements: OMB approval.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Information collection requirements: OMB approval. 25.8 Section 25.8 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.8...), 25.21(c), 25.27(b), 25.29, and 25.31, SF-86 is approved under control number 3206-0007. (3) In §...

  19. 40 CFR 258.14 - Seismic impact zones.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Seismic impact zones. 258.14 Section 258.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.14 Seismic impact zones. (a) New MSWLF units...

  20. Superfluid dynamics of 258Fm fission

    CERN Document Server

    Scamps, Guillaume; Lacroix, Denis

    2015-01-01

    Theoretical description of nuclear fission remains one of the major challenges of quantum many-body dynamics. The slow, mostly adiabatic motion through the fission barrier is followed by a fast, non-adiabatic descent of the potential between the fragments. The latter stage is essentially unexplored. However, it is crucial as it generates most of the excitation energy in the fragments. The superfluid dynamics in the latter stage of fission is obtained with the time-dependent Hartree-Fock theory including BCS dynamical pairing correlations. The fission modes of the 258Fm nucleus are studied. The resulting fission fragment characteristics show a good agreement with experimental data. Quantum shell effects are shown to play a crucial role in the dynamics and formation of the fragments. The importance of quantum fluctuations beyond the independent particle/quasi-particle picture is underlined and qualitatively studied.

  1. 42 CFR 422.258 - Calculation of benchmarks.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Calculation of benchmarks. 422.258 Section 422.258... and Plan Approval § 422.258 Calculation of benchmarks. (a) The term “MA area-specific non-drug monthly benchmark amount” means, for a month in a year: (1) For MA local plans with service areas entirely within...

  2. 40 CFR 258.22 - Disease vector control.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Disease vector control. 258.22 Section... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.22 Disease vector control. (a) Owners or operators of all MSWLF units must prevent or control on-site populations of disease vectors using...

  3. 40 CFR 258.27 - Surface water requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Surface water requirements. 258.27... FOR MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.27 Surface water requirements. MSWLF... wetlands, that violates any requirements of the Clean Water Act, including, but not limited to,...

  4. 40 CFR 258.51 - Ground-water monitoring systems.

    Science.gov (United States)

    2010-07-01

    ... preclude installation of ground-water monitoring wells at the relevant point of compliance at existing... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Ground-water monitoring systems. 258... CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Ground-Water Monitoring and Corrective Action § 258.51...

  5. OXA-258 from Achromobacter ruhlandii: a Species Specific Marker

    OpenAIRE

    Papalia, Mariana Andrea; Almuzara, Marisa; Cejas, Daniela; Traglia, German Matias; Ramirez, Maria Soledad; Galanternik, Laura; Vay, Carlos Alberto; Gutkind, Gabriel Osvaldo; Radice, Marcela Alejandra

    2015-01-01

    A new blaOXA-258 gene is described as species specific taxonomic marker for Achromobacter ruhlandii isolates (all recovered from cystic fibrosis patients). Even if the OXA-258 differs from OXA-114 variants, isolates could be misidentified as A. xiloxosidans by the amplification of an inner fragment from the OXA coding gene. A robust Identification of A. ruhlandii can be achieved by sequencing this single OXA gene as well as a more laborious recently proposed MLST scheme Fil: Papalia, Maria...

  6. OXA-258 from Achromobacter ruhlandii: a Species-Specific Marker

    OpenAIRE

    Papalia, Mariana Andrea; Almuzara, Marisa; Cejas, Daniela; Traglia, German Matias; Ramirez, Maria Soledad; Galanternik, Laura; Vay, Carlos Alberto; Gutkind, Gabriel Osvaldo; Radice, Marcela Alejandra

    2013-01-01

    A new blaOXA-258 gene is described as species specific taxonomic marker for Achromobacter ruhlandii isolates (all recovered from cystic fibrosis patients). Even if the OXA-258 differs from OXA-114 variants, isolates could be misidentified as A. xiloxosidans by the amplification of an inner fragment from the OXA coding gene. A robust Identification of A. ruhlandii can be achieved by sequencing this single OXA gene as well as a more laborious recently proposed MLST scheme Fil: Papalia, Maria...

  7. OXA-258 from Achromobacter ruhlandii: a species-specific marker.

    Science.gov (United States)

    Papalia, Mariana; Almuzara, Marisa; Cejas, Daniela; Traglia, German; Ramírez, Maria Soledad; Galanternik, Laura; Vay, Carlos; Gutkind, Gabriel; Radice, Marcela

    2013-05-01

    A new blaOXA-258 gene is described as a species-specific taxonomic marker for Achromobacter ruhlandii isolates (all recovered from cystic fibrosis patients). Even though OXA-258 differs from OXA-114 variants, isolates could be misidentified as A. xiloxosidans by the amplification of an inner fragment from the OXA-coding gene. A robust identification of A. ruhlandii can be achieved by sequencing this single OXA gene, as well as by a more laborious recently proposed multilocus sequence-typing (MLST) scheme.

  8. Phenotype abnormality: 258 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 258 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u764i disfunctional portion of meristem tissue... during process named cell division ... portion of meristem tissue ... disfunctional ... cell division ...

  9. 40 CFR 258.55 - Assessment monitoring program.

    Science.gov (United States)

    2010-07-01

    ... migration and sample this well in accordance with § 258.55(d)(2); (iii) Must notify all persons who own the... systemic toxicants, the level represents a concentration to which the human population (including sensitive... effects during a lifetime. For purposes of this subpart, systemic toxicants include toxic chemicals...

  10. 40 CFR 258.54 - Detection monitoring program.

    Science.gov (United States)

    2010-07-01

    ... FOR MUNICIPAL SOLID WASTE LANDFILLS Ground-Water Monitoring and Corrective Action § 258.54 Detection monitoring program. (a) Detection monitoring is required at MSWLF units at all ground-water monitoring wells... from the MSWLF unit to the ground water. In determining alternative parameters, the Director...

  11. 40 CFR 258.4 - Research, development, and demonstration permits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Research, development, and...) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS General § 258.4 Research, development, and... State may issue a research, development, and demonstration permit for a new MSWLF unit, existing MSWLF...

  12. 40 CFR 258.3 - Consideration of other Federal laws.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Consideration of other Federal laws... CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS General § 258.3 Consideration of other Federal laws. The owner... rules, laws, regulations, or other requirements....

  13. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Science.gov (United States)

    2010-07-01

    ... approval of self-employment plans. 21.258 Section 21.258 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Vocational Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of...

  14. 40 CFR 258.16 - Closure of existing municipal solid waste landfill units.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Closure of existing municipal solid waste landfill units. 258.16 Section 258.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.16...

  15. Microscopic description of 258Fm fission dynamic with pairing

    Directory of Open Access Journals (Sweden)

    Scamps Guillaume

    2016-01-01

    Full Text Available Fission dynamic remains a challenge for nuclear microscopic theories. In order to understand the dynamic of the last stage of the fission process, the time-dependent Hartree-Fock approach with BCS pairing is applied to the describe the fission of the 258Fm. A good agreement is found for the one-body observables: the total kinetic energy and the average mass asymmetry. The non-physical dependence of two-body observables with the initial shape is discussed.

  16. Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258

    Science.gov (United States)

    Dhar, Sorabh; Martin, Emily T.; Lephart, Paul R.; McRoberts, John P.; Chopra, Teena; Burger, Timothy T.; Tal-Jasper, Ruthy; Hayakawa, Kayoko; Ofer-Friedman, Hadas; Lazarovitch, Tsilia; Zaidenstein, Ronit; Perez, Federico; Bonomo, Robert A.; Kaye, Keith S.; Marchaim, Dror

    2016-01-01

    A “high risk” clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well defined. We conducted an epidemiological investigation of CRKP based on strains MLST. Among 68 CRKP patients, 61 were ST258 and 7 belonged to non-ST258. Klebsiella pneumoniae ST258 strains were significantly associated with blaKPC production and with resistance to an increased number of antimicrobials. Clinical outcomes were not different. Based on this analysis, one cannot rely solely on the presence of blaKPC in order to diagnose CRKP. PMID:26885543

  17. Phagocytosis and Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils.

    Science.gov (United States)

    Kobayashi, Scott D; Porter, Adeline R; Dorward, David W; Brinkworth, Amanda J; Chen, Liang; Kreiswirth, Barry N; DeLeo, Frank R

    2016-05-15

    Carbapenem-resistant Klebsiella pneumoniae strains classified as multilocus sequence type 258 (ST258) are among the most widespread multidrug-resistant hospital-acquired pathogens. Treatment of infections caused by these organisms is difficult, and mortality is high. The basis for the success of ST258, outside of antibiotic resistance, remains incompletely determined. Here we tested the hypothesis that ST258K. pneumoniae has enhanced capacity to circumvent killing by human neutrophils, the primary cellular defense against bacterial infections. There was limited binding and uptake of ST258 by human neutrophils, and correspondingly, there was limited killing of bacteria. On the other hand, transmission electron microscopy revealed that any ingested organisms were degraded readily within neutrophil phagosomes, thus indicating that survival in the neutrophil assays is due to limited phagocytosis, rather than to microbicide resistance after uptake. Our findings suggest that enhancing neutrophil phagocytosis is a potential therapeutic approach for treatment of infection caused by carbapenem-resistant ST258K. pneumoniae.

  18. Characterization of Group V Dubnium Homologs on DGA Extraction Chromatography Resin from Nitric and Hydrofluoric Acid Matrices

    Energy Technology Data Exchange (ETDEWEB)

    Despotopulos, J D; Sudowe, R

    2012-02-21

    Studies of the chemical properties of superheavy elements (SHE) pose interesting challenges due to their short half-lives and low production rates. Chemical systems must have extremely fast kinetics, fast enough kinetics to be able to examine the chemical properties of interest before the SHE decays to another nuclide. To achieve chemistry on such time scales, the chemical system must also be easily automated. Most importantly however, a chemical system must be developed which provides suitable separation and kinetics before an on-line study of a SHE can be performed. Relativistic effects make studying the chemical properties of SHEs interesting due to the impact these effects could have on the SHEs chemical properties. Relativistic effects arise when the velocity of the s orbital electrons approach the speed of light. As this velocity increases, the Bohr radius of the inner electron orbitals decreases and there is an increase in the particles mass. This contraction results in a destabilization of the energy of the outer d and f electron orbitals (5f and 6d in the case of SHE), which can cause these to expand due to their increased shielding from the nuclear charge. Another relativistic effect is the spin-orbit splitting for p, d, and f orbitals into j = 1 {+-} 1/2 states. This can lead most interestingly to a possible increased stability of element 114, which due to large spin-orbit splitting of the 7p orbital and the relativistically stabilized 7p{sub 1/2} and 7s orbital gives rise to a closed shell ground state of 7s{sup 2}7p{sub 1/2}{sup 2}. The homologs of element 105, dubnium (Db), Ta and Nb and the pseudo-homolog Pa, are well known to hydrolyze and form both neutral and non-neutral monoatomic and polyatomic species that may cause issues with extraction from a given chemical system. Early ion-exchange and solvent-extraction studies show mixed results for the behavior of Db. Some studies show Db behaving most similar to Ta, while others show it behaving

  19. 40 CFR 258.53 - Ground-water sampling and analysis requirements.

    Science.gov (United States)

    2010-07-01

    ....53 Ground-water sampling and analysis requirements. (a) The ground-water monitoring program must... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Ground-water sampling and analysis requirements. 258.53 Section 258.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)...

  20. 40 CFR 258.26 - Run-on/run-off control systems.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Run-on/run-off control systems. 258.26... FOR MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.26 Run-on/run-off control systems. (a) Owners or operators of all MSWLF units must design, construct, and maintain: (1) A run-on control system...

  1. Clinical analysis of 258 cases with hyponatremia%258例低钠血症临床分析

    Institute of Scientific and Technical Information of China (English)

    吴艳梅

    2012-01-01

    目的 探讨低钠血症发生的病因、诱因及血清钠浓度、年龄、预后的相关性.方法 收集258例低钠血症患者的临床资料包括年龄、病因、血清钠浓度、治疗及转归,进行回顾性分析.结果 60岁以上患者86.43%,60岁以下13.57%,不同程度低钠组平均年龄对比差异无统计学意义(P>0.05);死亡9.30%,轻度低钠组与中重度低钠组死亡率对比差异有统计学意义(x2=4.6999,P=0.0302,P<0.05);低钠血症的原发疾病以心脏病并心衰比例最大(25.58%).结论 低钠血症老年患者多见,心脏病并心衰合并低钠血症最常见,低钠血症程度与预后有相关.积极治疗原发病,消除诱发因素,避免医源性因素,及早发现、及时治疗是改善预后的关键.%OBJECTIVE To investigate the pathogenic and inducing factors of hyponatremia, and the correlation among serum sodium concentration, age and prognosis. METHODS The clinical data including the age, pathogenesis, serum sodium concentrations , treatment and effect of 258 patients with hyponatremia were collected for retrospective analysis. RESULTS Patients above and below 60 years old accounted for 86.43% and 13.57% respectively, and there was no significant difference in the mean age of groups with different degrees of hyponatremia (P > 0.05). The mortality rate was 9.30% and the difference in mortality rate between the mild and moderate-severe hyponatremia group was significant (χ2 = 4.699 9, P = 0.030 2, P < 0.05). Heart diseases with heart failure showed the largest proportion among all primary diseases complicated with hyponatremia (25.58%). CONCLUSION Hyponatremia is more common in old-age patients, and hyponatremia is the most common complication in heart diseases with heart failure. The degree of hyponatremia is correlated to the prognosis. Thus, it is important to actively treat the primary diseases, remove the inducing factors, avoid the iatrogenic factors and have early detection and

  2. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.

    Science.gov (United States)

    Deleo, Frank R; Chen, Liang; Porcella, Stephen F; Martens, Craig A; Kobayashi, Scott D; Porter, Adeline R; Chavda, Kalyan D; Jacobs, Michael R; Mathema, Barun; Olsen, Randall J; Bonomo, Robert A; Musser, James M; Kreiswirth, Barry N

    2014-04-01

    Infections caused by drug-resistant bacteria are a major problem worldwide. Carbapenem-resistant Klebsiella pneumoniae, most notably isolates classified as multilocus sequence type (ST) 258, have emerged as an important cause of hospital deaths. ST258 isolates are predominantly multidrug resistant, and therefore infections caused by them are difficult to treat. It is not known why the ST258 lineage is the most prevalent cause of multidrug-resistant K. pneumoniae infections in the United States and other countries. Here we tested the hypothesis that carbapenem-resistant ST258 K. pneumoniae is a single genetic clone that has disseminated worldwide. We sequenced to closure the genomes of two ST258 clinical isolates and used these genomes as references for comparative genome sequencing of 83 additional clinical isolates recovered from patients at diverse geographic locations worldwide. Phylogenetic analysis of the SNPs in the core genome of these isolates revealed that ST258 K. pneumoniae organisms are two distinct genetic clades. This unexpected finding disproves the single-clone hypothesis. Notably, genetic differentiation between the two clades results from an ∼ 215-kb region of divergence that includes genes involved in capsule polysaccharide biosynthesis. The region of divergence appears to be a hotspot for DNA recombination events, and we suggest that this region has contributed to the success of ST258 K. pneumoniae. Our findings will accelerate research on novel diagnostic, therapeutic, and vaccine strategies designed to prevent and/or treat infections caused by multidrug resistant K. pneumoniae.

  3. 37 CFR 258.4 - Royalty fee for secondary transmission of digital signals of broadcast stations by satellite...

    Science.gov (United States)

    2010-07-01

    ... transmission of digital signals of broadcast stations by satellite carriers. 258.4 Section 258.4 Patents... AND PROCEDURES ADJUSTMENT OF ROYALTY FEE FOR SECONDARY TRANSMISSIONS BY SATELLITE CARRIERS § 258.4 Royalty fee for secondary transmission of digital signals of broadcast stations by satellite carriers....

  4. 37 CFR 258.3 - Royalty fee for secondary transmission of analog signals of broadcast stations by satellite...

    Science.gov (United States)

    2010-07-01

    ... transmission of analog signals of broadcast stations by satellite carriers. 258.3 Section 258.3 Patents... AND PROCEDURES ADJUSTMENT OF ROYALTY FEE FOR SECONDARY TRANSMISSIONS BY SATELLITE CARRIERS § 258.3 Royalty fee for secondary transmission of analog signals of broadcast stations by satellite carriers....

  5. Yeast Interacting Proteins Database: YJL137C, YLR258W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ait as prey (1) YLR258W GSY2 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, ...ssion induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulat

  6. Yeast Interacting Proteins Database: YNL258C, YGL145W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YNL258C DSL1 Peripheral membrane protein required for Golgi-to-ER retrograde traffi...t description Peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER t

  7. Multiplex PCR for Identification of Two Capsular Types in Epidemic KPC-Producing Klebsiella pneumoniae Sequence Type 258 Strains

    Science.gov (United States)

    Chen, Liang; Chavda, Kalyan D.; Findlay, Jacqueline; Peirano, Gisele; Hopkins, Katie; Pitout, Johann D. D.; Bonomo, Robert A.; Woodford, Neil; DeLeo, Frank R.

    2014-01-01

    We developed a multiplex PCR assay capable of identifying two capsular polysaccharide synthesis sequence types (sequence type 258 [ST258] cps-1 and cps-2) in epidemic Klebsiella pneumoniae ST258 strains. The assay performed with excellent sensitivity (100%) and specificity (100%) for identifying cps types in 60 ST258 K. pneumoniae sequenced isolates. The screening of 419 ST258 clonal isolates revealed a significant association between cps type and K. pneumoniae carbapenemase (KPC) variant: cps-1 is largely associated with KPC-2, while cps-2 is primarily associated with KPC-3. PMID:24733470

  8. Genomic Analysis of the Emergence and Rapid Global Dissemination of the Clonal Group 258 Klebsiella pneumoniae Pandemic.

    Science.gov (United States)

    Bowers, Jolene R; Kitchel, Brandon; Driebe, Elizabeth M; MacCannell, Duncan R; Roe, Chandler; Lemmer, Darrin; de Man, Tom; Rasheed, J Kamile; Engelthaler, David M; Keim, Paul; Limbago, Brandi M

    2015-01-01

    Multidrug-resistant Klebsiella pneumoniae producing the KPC carbapenemase have rapidly spread throughout the world, causing severe healthcare-associated infections with limited antimicrobial treatment options. Dissemination of KPC-producing K. pneumoniae is largely attributed to expansion of a single dominant strain, ST258. In this study, we explore phylogenetic relationships and evolution within ST258 and its clonal group, CG258, using whole genome sequence analysis of 167 isolates from 20 countries collected over 17 years. Our results show a common ST258 ancestor emerged from its diverse parental clonal group around 1995 and likely acquired blaKPC prior to dissemination. Over the past two decades, ST258 has remained highly clonal despite diversity in accessory elements and divergence in the capsule polysaccharide synthesis locus. Apart from the large recombination event that gave rise to ST258, few mutations set it apart from its clonal group. However, one mutation occurs in a global transcription regulator. Characterization of outer membrane protein sequences revealed a profile in ST258 that includes a truncated OmpK35 and modified OmpK37. Our work illuminates potential genomic contributors to the pathogenic success of ST258, helps us better understand the global dissemination of this strain, and identifies genetic markers unique to ST258.

  9. Reading Ruth 4 and Leviticus 25:8–55 in the light of the landless ...

    African Journals Online (AJOL)

    2016-06-24

    Jun 24, 2016 ... resemblance to the situation of women in modern South Africa, ... Fernando Segovia to ancient texts have on the reading of Ruth 4 and Leviticus 25:8–55 in ..... and landlessness should have been a gender sensitive one.

  10. Single-Chain Antibody Fragment VEGF Inhibitor RTH258 for Neovascular Age-Related Macular Degeneration

    DEFF Research Database (Denmark)

    Holz, Frank G; Dugel, Pravin U; Weissgerber, Georges

    2016-01-01

    PURPOSE: To assess the safety and efficacy of different doses of RTH258 applied as single intravitreal administration compared with ranibizumab 0.5 mg in patients with neovascular age-related macular degeneration (AMD). DESIGN: Six-month, phase 1/2, prospective, multicenter, double-masked, random...

  11. Treating 258 cases of insomnia by acupuncture plus auricular acupressure%针刺配合耳压治疗失眠症258

    Institute of Scientific and Technical Information of China (English)

    张江层

    2010-01-01

    目的:探讨针刺配合耳压治疗失眠症的临床疗效.方法:选取本院258例患者,使用针刺配合耳压的方法治疗.结果:痊愈87例,显效101例,好转52例,无效18例,总有效率93%.结论:针刺配合耳穴贴压是治疗失眠症较满意的方法之一,值得临床应用.

  12. 258例高原老年消化性溃疡临床分析%CLINICAL ANALYSIS OF 258 PATIENTS WITH PEPTIC ULCER IN PLATEAU

    Institute of Scientific and Technical Information of China (English)

    窦炜

    2011-01-01

    [目的]探讨青海高原地区老年消化性溃疡的特点.[方法]对258例老年消化性溃疡患者进行相关因素分析,并与同期的中青年消化性溃疡260例进行对比. [结果] 258例老年消化性溃疡中,以呕血、黑便为首发症状179例(69.4%),高于中青年组的27例(10.4%) (P<0.01),高位溃疡和巨大溃疡发生率高,并发症184例(71.3%),伴随其他疾病者169例(65.5%),高于中青年组的48例(18.5%) (P<0.01). [结论]高原老年消化性溃疡具有发病率高、并发出血多、病情危重等特点,应在患者全身情况许可下尽早胃镜检查,给予治疗.同时应兼顾治疗并发症及伴随疾病,是提高生存质量、减少并发症、降低病死率的关键.%[Objective] To study the elderly peptic ulcer in Qinghai plateau. [Methods] The risk factors of 258 patients with peptic ulcer were analyzed, and in the same period, compared with 260 young and middle-aged cases of peptic ulcer disease. [Results] 258 patients with peptic ulcer, The rates of hematemesis and raelena as first symptoms (69.4%) were found in 179 cases, which higher than the younger group (10.4%) (P< 0.01) , the incidences of high ulcer and of giant ulcer were high, 184 cases complications (71.3%), along with other diseases, 169 cases (65.5%), which higher than the younger group (18.5%) (P< 0.01). [Conclusion] The with peptic ulcer disease among elderly patients in plateau is with characteristics including high incidence, bleeding, critical condition.lt should give gastroscopy in patients as soon as possible, and treat complications and associated diseases to improve the quality of life and reduce complications and mortality.

  13. 258例早产的临床因素分析%Clinical analysis on factors of 258 patients with premature birth

    Institute of Scientific and Technical Information of China (English)

    邹海燕

    2012-01-01

    OBJECTIVE To investigate and analyze risk factors of preterm birth and to explore interventions to reduce incidence of pretenn birth. METHODS Carried out case control study to investigate clinical data of 258 cases of premature and 258 mature maternities. In this study, used the Chi-square test to select the risk factors of pretenn birth and non-conditional Logistic regression analysis was used to further screen the main risk factors of preterm birth. RESULTS Pregnant women ≥30 years of age; suffering from pregnancy-induced hypertension; premature rupture of membranes; pregnancy reproductive tract infections; pregnancy smoking or passive smoking were the risk factors for preterm birth. CONCLUSION It should instruct pregnant women avoiding from a variety of risk factors for pretenn birth, and prevent and treat various complications during pregnancy to prevent preterm birth.%目的 探讨早产的相关危险因素,为降低早产的发生率提供理论依据.方法 采用病例对照研究,对258例早产产妇和258例足月产妇的临床资料进行调查,采用单因素卡方检验进行单因素分析筛选出早产危险因素;多因素非条件Logistic回归进一步筛选早产的主要危险因素.结果 孕妇≥30岁;患有妊高症;胎膜早破;孕期生殖道感染;孕期吸烟或被动吸烟是早产发生的危险因素.结论 应指导孕妇避免各种早产的危险因素,并对妊娠期的各种并发症进行积极防治,从而有效地预防早产的发生.

  14. Emergence of carbapenemase-producing Klebsiella pneumoniae of sequence type 258 in Michigan, USA

    Directory of Open Access Journals (Sweden)

    Ruchika Jain

    2013-03-01

    Full Text Available The prevalence of carbapenemase-producing Enterobacteriaceae (CPE in our hospital increased beginning in 2009. We aimed to study the clinical and molecular epidemiology of these emerging isolates. We performed a retrospective review of all adult patients with clinical cultures confirmed as CPE by positive modified Hodge test from 5/2009-5/2010 at the University of Michigan Health System (UMHS. Clinical information was obtained from electronic medical records. Available CPE isolates were analyzed by polymerase chain reaction (PCR and sequencing of the 16S rRNA encoding gene and blaKPC locus. Multilocus sequence typing (MLST was used to characterize Klebsiella pneumoniae isolates. Twenty six unique CPE isolates were obtained from 25 adult patients. The majority were Klebsiella pneumoniae (n=17. Other isolates included K. oxytoca (n=3, Citrobacter freundii (n=2, Enterobacter cloacae (n=2, Enterobacter aerogenes (n=1 and Escherichia coli (n=1. Molecular characterization of 19 available CPE isolates showed that 13 (68% carried the KPC-3 allele and 6 (32% carried the KPC-2 allele. Among 14 available K. pneumoniae strains, 12 (86% carried the KPC-3 allele and belonged to a common lineage, sequence type (ST 258. The other 2 (14% K. pneumoniae isolates carried the KPC-2 allele and belonged to two unique STs. Among these ST 258 strains, 67% were isolated from patients with prior exposures to health care settings outside of our institution. In contrast, all CPE isolates carrying the KPC-2 allele and all non ST 258 CPE isolates had acquisition attributable to our hospital. Molecular epidemiology of carbapenemase producing K. pneumoniae suggests that KPC-3 producing K. pneumoniae isolates of a common lineage, sequence type (ST 258, are emerging in our hospital. While ST 258 is a dominant sequence type throughout the United States, this study is the first to report its presence in Michigan.

  15. Identification of Outer Membrane and Exoproteins of Carbapenem-Resistant Multilocus Sequence Type 258 Klebsiella pneumoniae.

    Directory of Open Access Journals (Sweden)

    Amanda J Brinkworth

    Full Text Available Carbapenem-resistant Klebsiella pneumoniae strains have emerged as a cause of life-threatening infections in susceptible individuals (e.g., transplant recipients and critically ill patients. Strains classified as multilocus sequence type (ST 258 are among the most prominent causes of carbapenem-resistant K. pneumoniae infections worldwide, but the basis for the success of this lineage remains incompletely determined. To gain a more comprehensive view of the molecules potentially involved in the success of ST258, we used a proteomics approach to identify surface-associated and culture supernatant proteins produced by ST258. Protein samples were prepared from varied culture conditions in vitro, and were analyzed by a combination of two-dimensional electrophoresis and liquid chromatography followed by tandem mass spectrometry (LC-MS/MS. We identified a total of 193 proteins in outer membrane preparations from bacteria cultured in Luria-Bertani broth (LB or RPMI 1640 tissue culture media (RPMI. Compared with LB, several iron-acquisition proteins, including IutA, HmuR, HmuS, CirA, FepA, FitA, FoxA, FhuD, and YfeX, were more highly expressed in RPMI. Of the 177 proteins identified in spent media, only the fimbrial subunit, MrkA, was predicted to be extracellular, a finding that suggests few proteins (or a limited quantity are freely secreted by ST258. Notably, we discovered 203 proteins not reported in previous K. pneumoniae proteome studies. In silico modeling of proteins with unknown function revealed several proteins with beta-barrel transmembrane structures typical of porins, as well as possible host-interacting proteins. Taken together, these findings contribute several new targets for the mechanistic study of drug-resistance and pathogenesis by ST258 K. pneumoniae isolates.

  16. GRS 1758–258: RXTE Monitoring of a Rare Persistent Hard State Black Hole

    Directory of Open Access Journals (Sweden)

    M. Obst

    2011-01-01

    Full Text Available GRS 1758–258 is the least studied of the three persistent black hole X-ray binaries in our Galaxy. It is also one of only two known black hole candidates, including all black hole transients, which shows a decrease of its 3-10 keV flux when entering the thermally dominated soft state, rather than an increase.We present the spectral evolution of GRS 1758–258 from RXTE-PCA observations spanning a time of about 11 years from 1996 to 2007. During this time, seven dim soft states are detected. We also consider INTEGRAL monitoring observations of the source and compare the long-term behavior to that of the bright persistent black hole X-ray binary Cygnus X-1. We discuss the observed state transitions in the light of physical scenarios for black hole transitions.

  17. Arsenic efflux governed by the arsenic resistance determinant of Staphylococcus aureus plasmid pI258.

    OpenAIRE

    Bröer, S; Ji, G.; Bröer, A; Silver, S

    1993-01-01

    The arsenic resistance operon of Staphylococcus aureus plasmid pI258 determined lowered net cellular uptake of 73As by an active efflux mechanism. Arsenite was exported from the cells; intracellular arsenate was first reduced to arsenite and then transported out of the cells. Resistant cells showed lower accumulation of 73As originating from both arsenate and arsenite. Active efflux from cells loaded with arsenite required the presence of the plasmid-determined arsB gene. Efflux of arsenic or...

  18. Optical spectroscopy of the microquasar GRS 1758-258: a possible intermediate mass system?

    Science.gov (United States)

    Martí, Josep; Luque-Escamilla, Pedro L.; Muñoz-Arjonilla, Álvaro J.

    2016-11-01

    Context. GRS 1758-258 is one of two prototypical microquasars towards the Galactic center direction discovered almost a quarter of a century ago. The system remains poorly studied in the optical domain due to its counterpart being a very faint and absorbed target in a crowded region of the sky. Aims: Our aim is to investigate GRS 1758-258 in order to shed light on the nature of the stellar binary components. In particular, the main physical parameters of the donor star, such as the mass or the spectral type, are not yet well constrained. Methods: GRS 1758-258 has remained so far elusive to optical spectroscopy owing to its observational difficulties. Here, we use this traditional tool of stellar astronomy at low spectral resolution with a 10 m class telescope and a long slit spectrograph. Results: An improved spectrum is obtained as compared to previous work. The quality of the data does not allow the detection of emission or absorption features but, nevertheless, we manage to partially achieve our aims comparing the de-reddened continuum with the spectral energy distribution expected from an irradiated disc model and different donor star templates. Conclusions: We tentatively propose that GRS 1758-258 does not host a giant star companion. Instead, a main sequence star with mid-A spectral type appears to better agree with our data. The main impacts of this finding are the possibility that we are dealing with an intermediate mass system and, in this case, the prediction of an orbital period significantly shorter than previously proposed.

  19. 40 CFR Appendix II to Part 258 - List of Hazardous Inorganic and Organic Constituents

    Science.gov (United States)

    2010-07-01

    ... Acenaphthylene Acetone 67-64-1 2-Propanone Acetonitrile; Methyl cyanide 75-05-8 Acetonitrile Acetophenone 98-86-2...)- beta-BHC 319-85-7 Cyclohexane, 1,2,3,4,5,6-hexachloro-,(1α,2β,3α,4β,5α,6β)- delta-BHC 319-86-8... 258—List of Hazardous Inorganic and Organic Constituents Common name 1 CAS RN 2 Chemical...

  20. Optical spectroscopy of the microquasar GRS 1758-258: a possible intermediate mass system?

    CERN Document Server

    Martí, Josep; Muñoz-Arjonilla, Álvaro J

    2016-01-01

    Context. GRS 1758-258 is one of two prototypical microquasars towards the Galactic Center direction discovered almost a quarter of a century ago. The system remains poorly studied in the optical domain due to its counterpart being a very faint and absorbed target in a crowded region of the sky. Aims. Our aim is to investigate GRS 1758-258 in order to shed light on the nature of the stellar binary components. In particular, the main physical parameters of the donor star, such as the mass or the spectral type, are not yet well constrained. Methods. GRS 1758-258 has remained so far elusive to optical spectroscopy owing to its observational difficulties. Here, we use this traditional tool of stellar astronomy at low spectral resolution with a 10 m class telescope and a long slit spectrograph. Results. An improved spectrum is obtained as compared to previous work. The quality of the data does not allow the detection of emission or absorption features but, nevertheless, we manage to partially achieve our aims compa...

  1. Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection

    Science.gov (United States)

    Ahn, Danielle; Peñaloza, Hernán; Wang, Zheng; Wickersham, Matthew; Parker, Dane; Patel, Purvi; Koller, Antonius; Chen, Emily I.; Bueno, Susan M.; Uhlemann, Anne-Catrin; Prince, Alice

    2016-01-01

    Adaptive changes in the genome of a locally predominant clinical isolate of the multidrug-resistant Klebsiella pneumoniae ST258 (KP35) were identified and help to explain the selection of this strain as a successful pulmonary pathogen. The acquisition of 4 new ortholog groups, including an arginine transporter, enabled KP35 to outcompete related ST258 strains lacking these genes. KP35 infection elicited a monocytic response, dominated by Ly6Chi monocytic myeloid-derived suppressor cells that lacked phagocytic capabilities, expressed IL-10, arginase, and antiinflammatory surface markers. In comparison with other K. pneumoniae strains, KP35 induced global changes in the phagocytic response identified with proteomics, including evasion of Ca2+ and calpain activation necessary for phagocytic killing, confirmed in functional studies with neutrophils. This comprehensive analysis of an ST258 K. pneumoniae isolate reveals ongoing genetic adaptation to host microenvironments and innate immune clearance mechanisms that complements its repertoire of antimicrobial resistance genes and facilitates persistence in the lung. PMID:27777978

  2. Isotopic yield in cold binary fission of even-even $^{244-258}$Cf isotopes

    CERN Document Server

    Santhosh, K P; Krishnan, Sreejith

    2016-01-01

    The cold binary fission of even-even 244-258Cf isotopes has been studied by taking the interacting barrier as the sum of Coulomb and proximity potential. The favorable fragment combinations are obtained from the cold valley plot (plot of driving potential vs. mass number of fragments) and by calculating the yield for charge minimized fragments. It is found that highest yield for 244,246,248Cf isotopes are for the fragments with isotope of Pb (Z=82) as one fragment, whereas for 250Cf and 252Cf isotopes the highest yield is for the fragments with isotope of Hg (Z=80) as one fragment. In the case of 254,256,258Cf isotopes the highest yield is for the fragments with Sn (Z=50) as one fragment. Thus, the fragment combinations with maximum yield reveal the role of doubly magic and near doubly magic nuclei in binary fission. It is found that asymmetric splitting is favoured for Cf isotopes with mass number A 252. In the case of Cf isotope with A=252, there is an equal probability for asymmetric and symmetric splitti...

  3. 258例儿童哮喘危险因素的Logistic回归分析%Logistic regression analysis on risk factors of 258 children with asthma

    Institute of Scientific and Technical Information of China (English)

    李晶; 侯丽影; 周雅燕

    2012-01-01

    目的:探讨哮喘的相关危险因素,为儿童哮喘的防治提供参考.方法:以258例儿童哮喘患者为观察组,同时从门诊随机抽取240例无哮喘病史的人群作为对照组.应用非条件Logistic回归分析进行多因素分析.结果:单因素分析结果表明:两组间上呼吸道感染、运动、天气变化、情绪变化、饮食、鼻炎、个人过敏史、家族过敏史、家族哮喘史比较差异有统计学意义(P<0.05).多因素分析结果表明:上呼吸道感染、运动、饮食、鼻炎、个人过敏史、家族过敏史、家族哮喘史是儿童发生哮喘的独立危险因素(P<0.05).结论:上呼吸道感染、运动、饮食、鼻炎、个人过敏史、家族过敏史、家族哮喘史是儿童发生哮喘的独立危险因素,对这些危险因素进行必要的干预可能降低哮喘的发生率.%Objective: To explore the related risk factors ol asthma, and provide reference for prevention and treatment of children with asthma. Methods: A total of 258 children with asthma were selected as observation group, meanwhile, 240 cases without asthma were selected from outpatient department of the hospital as control group, non - conditional logistic regression analysis was performed for multivari-ate analysis. Results: The results of univariate regression analysis showed that there was statistically significant difference in the incidence of upper respiratory tract infection, sports, changes of weather, changes of emotion , diet, rhinitis, personal allergic history, family allergic history, and family asthmatic history between the two groups (P <0. 05) . The results of multivariate regression analysis showed that upper respiratory tract infection, sports, diet, rhinitis, personal allergic history, family allergic history, and family asthmatic history were independent risk factors of asthma in children, there was statistical significance (P<0. 05) . Conclusion: Upper respiratory tract infection, sports, diet

  4. Microscopic phase-space exploration modeling of $^{258}$Fm spontaneous fission

    CERN Document Server

    Tanimura, Yusuke; Ayik, Sakir

    2016-01-01

    We show that the total kinetic energy (TKE) of nuclei after the spontaneous fission of $^{258}$Fm can be well reproduced using simple assumptions on the quantum collective phase-space explored by the nucleus after passing the fission barrier. Assuming energy conservation and phase-space exploration according to the stochastic mean-field approach, a set of initial densities is generated. Each density is then evolved in time using the nuclear time-dependent density-functional theory. This approach goes beyond mean-field by allowing spontaneous symmetry breaking as well as a wider dynamical phase-space exploration leading to larger fluctuations in collective space. The total kinetic energy and mass distributions are calculated. New information on the fission process: fluctuations in scission time, strong correlation between TKE and collective deformation of daughter nuclei as well as pre- and post-scission particle emission, are obtained.

  5. Accretion States of the Galactic Micro Quasar GRS 1758-258

    Science.gov (United States)

    Soria, Roberto; Mehdipour, Missagh; Broderick, Jess W.; Hao, JingFang; Hannikainen, Diana C.; Pottschmidt, Katja; Zhang, Shuang-Nan

    2011-01-01

    We present the results of a radio and X-ray study of the Galactic micro quasar GRS 1758-258, using unpublished archival data and new observations. We focus in particular on the 2000-2002 state transitions, and on its more quiet behaviour in 2008-2009. Our spectral and timing analysis of the XMM-Newton data shows that the source was in the canonical intermediate, soft and hard states in 2000 September 19,2001 March 22 and 2002 September 28, respectively. We estimate the disk size, luminosity and temperature, which are consistent with a black hole mass approx.10 Solar Mass, There is much overlap between the range of total X-ray luminosities (on average approx. 0.02L(sub Edd)) in the hard and soft states, and probably between the corresponding mass accretion rates; in fact, the hard state is often more luminous. The extended radio lobes seen in 1992 and 1997 are still present in 2008-2009. The 5-GHz radio core flux density has shown variability between approx. 0.1-0.5 mJy over the last two decades. This firmly places GRS 1758-258 in the radio-quiet sequence of Galactic black holes, in the radio/X-ray plane. We note that this dichotomy is similar to the dichotomy between the radio/X-ray sequences of Seyfert and radio galaxies. We propose that the different radio efficiency of the two sequences is due to relativistic electron/positron jets in radio-loud black holes, and sub-relativistic, thermally dominated outflows in radio-quiet sources.

  6. Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258 and its Therapeutic Implications

    Directory of Open Access Journals (Sweden)

    Shalini S. Yadav

    2017-06-01

    Full Text Available Prostate cancer (PCa remains the second-leading cause of cancer-related deaths in American men with an estimated mortality of more than 26,000 in 2016 alone. Aggressive and metastatic tumors are treated with androgen deprivation therapies (ADT; however, the tumors acquire resistance and develop into lethal castration resistant prostate cancer (CRPC. With the advent of better therapeutics, the incidences of a more aggressive neuroendocrine prostate cancer (NEPC variant continue to emerge. Although de novo occurrences of NEPC are rare, more than 25% of the therapy-resistant patients on highly potent new-generation anti-androgen therapies end up with NEPC. This, along with previous observations of an increase in the number of such NE cells in aggressive tumors, has been suggested as a mechanism of resistance development during prostate cancer progression. Dovitinib (TKI-258/CHIR-258 is a pan receptor tyrosine kinase (RTK inhibitor that targets VEGFR, FGFR, PDGFR, and KIT. It has shown efficacy in mouse-model of PCa bone metastasis, and is presently in clinical trials for several cancers. We observed that both androgen receptor (AR positive and AR-negative PCa cells differentiate into a NE phenotype upon treatment with Dovitinib. The NE differentiation was also observed when mice harboring PC3-xenografted tumors were systemically treated with Dovitinib. The mechanistic underpinnings of this differentiation are unclear, but seem to be supported through MAPK-, PI3K-, and Wnt-signaling pathways. Further elucidation of the differentiation process will enable the identification of alternative salvage or combination therapies to overcome the potential resistance development.

  7. Characteristics of KPC-2-producing Klebsiella pneumoniae (ST258) clinical isolates from outbreaks in 2 Mexican medical centers.

    Science.gov (United States)

    Garza-Ramos, Ulises; Barrios, Humberto; Reyna-Flores, Fernando; Sánchez-Pérez, Alejandro; Tamayo-Legorreta, Elsa; Ibarra-Pacheco, Alvaro; Salazar-Salinas, Juana; Núñez-Ceballos, Ricardo; Silva-Sanchez, Jesus

    2014-08-01

    The KPC-producing Klebsiella pneumoniae sequence type 258 (ST258) is an important pathogen widely spread in nosocomial infections. In this study, we identified the KPC-2-producing K. pneumoniae clinical isolates of 2 unrelated outbreaks that corresponded to pandemic strain ST258. The isolates showed high resistance to cephalosporins, carbapenems, quinolones, and colistin. The KPC-2-producing K. pneumoniae isolates were compared to the previously studied KPC-3-producing K. pneumoniae isolates from an outbreak in Mexico; they showed an unrelated pulsed-field gel electrophoresis fingerprinting pattern and a different plasmid profile. The KPC-2 carbapenemase gene was identified in two 230- and 270-kb non-conjugative plasmids; however, 1 isolate transferred the KPC-2 gene onto an 80-kb plasmid. These findings endorse the need of carrying out a continuous molecular epidemiological surveillance of carbapenem-resistant isolates in hospitals in Mexico.

  8. Rotational properties in even-even superheavy $^{254-258}$Rf nuclei based on total-Routhian-surface calculations

    CERN Document Server

    Hua-Lei, Wang; Jin-Ge, Jiang; Min-Liang, Liu

    2013-01-01

    High-spin yrast structures of even-even superheavy nuclei $^{254-258}$Rf are investigated by means of total-Routhian-surface approach in three-dimensional ($\\beta_2, \\gamma, \\beta_4$) space. The behavior in the moments of inertia of $^{256}$Rf is well reproduced by our calculations, which is attributed to the $j_{15/2}$ neutron rotation-alignment. The competition between rotationally aligned $i_{13/2}$ proton and $j_{15/2}$ neutron is discussed. High-spin predictions are also made for its neighboring isotopes $^{254,258}$Rf.

  9. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

    2016-01-01

    OBJECTIVES: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient popula

  10. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : A systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M. J D|info:eu-repo/dai/nl/357298969; Haverkate, M. R.; Bonten, M. J M|info:eu-repo/dai/nl/123144337; Bootsma, M. C J

    2016-01-01

    Objectives: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient

  11. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

    2016-01-01

    OBJECTIVES: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient

  12. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J|info:eu-repo/dai/nl/304830305

    2016-01-01

    OBJECTIVES: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient popula

  13. Analysis of 258 cases of uterine endometrial carcinoma in 18 years

    Energy Technology Data Exchange (ETDEWEB)

    Akutagawa, Noriyuki; Nishikawa, Akira; Saito, Tsuyoshi; Sagae, Satoru; Kudo, Ryuichi [Sapporo Medical Coll. (Japan)

    1999-12-01

    We investigated 258 cases of uterine endometrial cancer diagnosed and treated from 1980 through 1997 at our institution. Disease outcome, adjuvant therapies, and histologic features were analyzed. Patients' ages ranged from 20 to 90 years (mean, 57.0{+-}10.8 years). The 5-year survival rates were 97.5% for stage I disease, 81.7% for stage II disease, 69.8% for stage III disease, and 0% for stage IV disease. Patients with stage III disease who received both chemotherapy and radiation therapy as adjuvant therapies survive slightly, but not significantly, longer than did patients who received chemotherapy alone or radiation alone or no adjuvant therapy. The 136 patients (59.9%) with well-differentiated (G1) endometrioid carcinomas were significantly younger (mean age, 55.9{+-}10.3 years) than the 58 (25.6%) patients with moderately differentiated carcinomas (G2, 59.9{+-}10.4 years, p=0.01) and the 33 patients (14.5%) with poorly differentiated (G3, 59.9{+-}8.2 years, p=0.04) endometrioid carcinomas. The 60 cases of endometrial carcinoma from 1994 through 1997 were examined to determine whether endometrial hyperplasia and adenocarcinoma coexist. Endometrial hyperplasia was present in 23 (38%) of the 60 cases. The patients with both endometrial hyperplasia and adenocarcinoma were significantly younger (mean age, 47.7{+-}10.9 years) than the patients with endometrial adenocarcinoma alone (mean age, 59.5{+-}9.5 years, p<0.001). (author)

  14. A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI-258), Enhances BMP-2-Induced Osteoblast Differentiation In Vitro

    Science.gov (United States)

    Lee, Yura; Bae, Kyoung Jun; Chon, Hae Jung; Kim, Seong Hwan; Kim, Soon Ae; Kim, Jiyeon

    2016-01-01

    Dovitinib (TKI258) is a small molecule multi-kinase inhibitor currently in clinical phase I/II/III development for the treatment of various types of cancers. This drug has a safe and effective pharmacokinetic/pharmacodynamic profile. Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. Dovitinib also stimulated the translocation of phosphorylated Smad1/5/8 into the nucleus and phosphorylation of mitogen-activated protein kinases, including ERK1/2 and p38. In addition, the mRNA expression of BMP-4, BMP-7, ALP, and OCN increased with dovitinib treatment. Our results suggest that dovitinib has a potent stimulating effect on BMP-2-induced osteoblast differentiation and this existing drug has potential for repositioning in the treatment of bone-related disorders. PMID:27025387

  15. [Analyzing the occupational hazard of 258 construction projects of Shunde in 2010 and 2011].

    Science.gov (United States)

    Zeng, Qing-min; Yu, Zhuo-wen; Fu, Fa-xiong; Zuo, Zhi-hua; Liu, Yi-min

    2012-05-01

    To understand the changing trend of occupational hazard of industries in Shunde area and to provide the scientific evidence for the prevention of occupational diseases. The pre-evaluation of occupational hazard was carried out for the construction projects. The data about employee number scale, industry species, occupational hazard factors, hazard levels and prevention measures for construction projects were collected and analyzed. The data of Shunde Occupational Health Survey in 2011 served as the control data. There were 258 construction projects in 2010 and 2011, in which the proportions of medium and large scales increased to 8.1% and 2.4% respectively, the proportions of the furniture and chemical industries decreased from 25.6% or/and 5.1% to 2.7% or/and 1.8%, the proportions of the high-tech industries increased from 1.8% to 9.2%. The proportions of the projects with serious, medium and slight occupational hazard levels were 4.3%, 67.8% and 27.9%, respectively. The proportions of the projects with harmful chemicals, dusts and physical factors were 34.2%, 46.8%, 42.6%, respectively. The feature of occupational hazard in Shunde industries has changed at upgrading stage. We should pay attention to the prevention of occupational diseases in high-tech industries.

  16. Monitoring the Black Hole Binary GRS 1758-258 with INTEGRAL and RXTE

    Science.gov (United States)

    Pottschmidt, Katja; Chernyakova, Masha; Lubinski, Piotr; Migliari, Simone; Smith, David M.; Zdziarski, Andrzej A.; Tomsick, John A.; Bezayiff, N.; Kreykenbohm, Ingo; Kretschmar, Peter; hide

    2008-01-01

    The microquasar GRS 1758-258 is one of only three persistent black hole binaries that spend most of their time in the hard spectral state, the other two being Cyg X-l and 1E 1741.7-2942. It therefore provides the rare opportunity for an extensive long term study of this important black hole state which is associated with strong variability and radio jet emission. INTEGRAL has been monitoring the source since the first Galactic Center Deep Exposure season in spring 2003 during two 2-3 months long Galactic Center viewing epochs each year, amounting to 11 epochs including spring of 2008. With the exception of the last epoch quasi-simultaneous RXTE monitoring observations are available as well. Here we present an analysis of the epoch averaged broad band spectra which display considerable long term variability, most notably the occurrence of two soft/off states, extreme examples for the hysteretic behavior of black hole binaries. The hard source spectrum and long exposures allow us to extend the analysis for several epochs to approximately 800 keV using PICsIT data and address the question of the presence of a non-thermal Comptonization component.

  17. Clinical study of cerebral palsy in 258 preterm infants%早产儿脑性瘫痪258例临床研究

    Institute of Scientific and Technical Information of China (English)

    侯梅; 孙殿荣; 单若冰; 隋晓峰; 王珂

    2011-01-01

    [Objective]To investigate the related risk factors、clinical types distributions、the level of movement disorder and neuroimaging characters、the comorbiditie in preterm infants with cerebral palsy (CP).[Methods]A clinical study of cross section based on Qingdao special hospital.The preterm children with cerebral palsy hospitalized in rehabilitation center from January 2006 to June 2010 were studied.Perinatal data were collected by the researchers using the questionnaire and meeting with children’s mother; Gross Motor Function Classification System(GMFCS) was adopted to evaluate the levels of movement disorder;every children accepted the intelligence test, eye examination and speech evaluation.And the children who were suspected with auditory disorders had brain stem auditory evoked potential examination.[Results]Among the 258 cases, 199 cases with spastic type CP.The levels of GMFCS of spastic diplegia and hemiplegia were better than the dyskinetic、spastic tetraplegia and the mixed type(F= 4.362,P<0.01).The distributions of comorbidites were different between the different types of cerebral palsy and the levels of GMFCS.170 cases(65.89%) with cerebral palsy had periventricular leukomalacia(PVL) which could be seen in all types of CP but more frequently in the spastic diplegia and tetraplegia.These can benefit the early screening and early diagnose of CP of premature and also help the localization and qualitation of the comorbidities.[Conclusions]CP together with associated disorders become the focus of premature infants.It is important to recognize the clinical aspects, neuroimaging features and the comorbidities of them for etiological research and general rehabilitation administration.%[目的]探讨早产儿脑瘫的高危因素、脑瘫类型、运动障碍程度、影像学特点及共患病情况.[方法]专科医院为基础的横断面临床研究,研究对象为2006年1月-2010年6月在本院脑瘫康复中心住院治疗的早产儿脑瘫患

  18. Two cases of monomicrobial intraabdominal abscesses due to KPC - 3 Klebsiella pneumoniae ST258 clone

    Directory of Open Access Journals (Sweden)

    Madonia Simona

    2011-09-01

    Full Text Available Abstract Background Knowledge of the etiology of pyogenic liver and pancreatic abscesses is an important factor in determining the success of combined surgical and antibiotic treatment. Literature shows geographical variations in the prevalence and distribution of causative organisms, and the spread of Klebsiella pneumoniae carbapenemase-producing bacteria is an emerging cause of abdominal infections. Case presentation We herein describe two cases of intra-abdominal abscesses due to monomicrobial infection by Klebsiella pneumoniae Sequence Type 258 producing K. pneumoniae carbapenemase 3 (KPC-Kp. In case 1, a 50-year-old HIV-negative Italian woman with chronic pancreatitis showed infection of a pancreatic pseudocystic lesion caused by KPC-Kp. In case 2, a 64-year-old HIV- negative Italian woman with pancreatic neoplasm and liver metastases developed a liver abscess due to KPC after surgery. Both women were admitted to our hospital but to different surgical units. The clonal relationship between the two isolates was investigated by pulsed-field gel electrophoresis (PFGE. In case 2, the patient was already colonized at admission and inter-hospital transmission of the pathogen was presumed. A long-term combination regimen of colistin with tigecycline and percutaneous drainage resulted in full recovery and clearance of the multidrug-resistant (MDR pathogen. Conclusions Timely microbiological diagnosis, the combined use of new and old antibiotics and radiological intervention appeared to be valuable in managing these serious conditions. The emergence and dissemination of MDR organisms is posing an increasing challenge for physicians to develop new therapeutic strategies and control and prevention frameworks.

  19. 菠萝AcSERK15’上游区(-499/+258bp)转录活性的研究%Transcriptional activity of the 5' upstream region (-499/+258 bp) of AcSERK1

    Institute of Scientific and Technical Information of China (English)

    林文秋; 陈程杰; 栾爱萍; 张俊丽; 冯筠挺; 张雅芬; 郭翠红; 何业华

    2016-01-01

    [目的]探究AcSERK1启动子的功能,有助于了解AcSERK1的表达调控模式.[方法]以‘神湾’菠萝(Ananas comosus L.‘Shenwan’)为材料,将AcSERK1启动子缺失序列与GUS融合,构建植物表达载体,并导入根瘤农杆菌GV3101中.利用农杆菌真空渗透法侵染烟草叶片,并检测GUS活性;利用浸染法转化菠萝胚性愈伤组织获得转基因植株,分析光照、2,4-D和4 c℃等处理后的GUS表达量.[结果]构建2个AcSERK1启动子植物缺失表达载体,分别命名为p(-30/+258 bp)和p(-499/+258 bp).烟草瞬时表达结果显示p(-499/+258 bp)表现出强的GUS活性,p(-30/+258 bp)表现出微弱的GUS活性.qRT-PCR结果表明,光照处理后,GUS表达量降低.相反的,2A-D和4℃处理转基因菠萝植株后GUS表达量均显著增加.[结论]AcSERK1启动子-499/-30 bp区段内含有光、生长素和低温响应元件.

  20. Fission of 255,256Es, 255-257Fm, and 258Md at moderate excitation energies

    NARCIS (Netherlands)

    Britt, H.C.; Hoffman, D.C.; Plicht, J. van der; Wilhelmy, J.; Cheifetz, E.; Dupzyk, R.J.; Lougheed, R.W.

    1984-01-01

    The fission of 255,256Es, 255-257Fm, and 258Md has been studied in the excitation energy range from threshold to 25 MeV. A target of 254Es was used in the direct reaction studies; (d,pf), (t,pf), (3He,df), (3He,pf), and in the compound induced fission reactions formed with p, d, t, and α particle pr

  1. Fission of 255,256Es, 255-257Fm, and 258Md at moderate excitation energies

    NARCIS (Netherlands)

    Britt, H.C.; Hoffman, D.C.; Plicht, J. van der; Wilhelmy, J.; Cheifetz, E.; Dupzyk, R.J.; Lougheed, R.W.

    1984-01-01

    The fission of 255,256Es, 255-257Fm, and 258Md has been studied in the excitation energy range from threshold to 25 MeV. A target of 254Es was used in the direct reaction studies; (d,pf), (t,pf), (3He,df), (3He,pf), and in the compound induced fission reactions formed with p, d, t, and α particle

  2. Simultaneous Observations of GRS 1758-258 in 1997 by VLA, IRAM, SEST, RXTE and OSSE Spectroscopy and Timing

    CERN Document Server

    Lin, D; Liang, E P; Bridgman, T; Smith, D M; Martí, J; Durouchoux, P; Mirabel, I F; Rodríguez, L F; Durouchoux, Ph.

    1999-01-01

    We report the results of our multi-wavelength observations of GRS 1758-258 made in August 1997. The energy bands include radio, millimeter, X-ray, and gamma-ray. The observations enable us to obtain a complete spectrum of the source over an energy range of 2 - 500 keV. The spectrum shows that GRS 1758-258 was in its hard state. It is well fitted by the Sunyaev-Titarchuk (ST) Compton scattering model. The spectrum is also fit by a power law with an exponential cutoff (PLE) plus a soft black-body component. The temperature of the soft component is about 1.2 keV, and the energy flux is less than 1.5% of the total X- and gamma-ray flux. The deduced hydrogen column density is in the range of (0.93 - 2.0) 10^{22} cm^{-2}. No significant iron lines are detected. The radio emission has a flat energy spectrum. The daily radio, X-ray and gamma-ray light curves show that GRS 1758-258 was stable during the observation period, but was highly variable on smaller time scales in X- and gamma-rays. The power density spectra a...

  3. Development and validation of a multiplex PCR assay for identification of the epidemic ST-258/512 KPC-producing Klebsiella pneumoniae clone.

    Science.gov (United States)

    Adler, Amos; Khabra, Efrat; Chmelnitsky, Inna; Giakkoupi, Panagiota; Vatopoulos, Alkiviadis; Mathers, Amy J; Yeh, Anthony J; Sifri, Costi D; De Angelis, Giulia; Tacconelli, Evelina; Villegas, Maria-Virginia; Quinn, John; Carmeli, Yehuda

    2014-01-01

    The Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) sequence type (ST)-258/512 clone is the dominant clone by which KPC has disseminated worldwide. Standard typing methods are time-consuming and are therefore impractical for identification of this clone in the course of an outbreak. Through comparative genomic study, we have previously identified several presumably unique genes of this clone: 1) PILV-like protein (pilv-l), 2) transposase, IS66-family (is-66), and a 3) phage-related protein (prp). Our aims were to 1) test for the presence of these genes using a multiplex PCR in a large, multinational collection of KPC-KP isolates and to 2) validate this assay as a typing method for the identification of the ST-258/512 clone. KPC-KP isolates (n=160) that included both ST-258/512 (group A, n=114) and non-ST-258 (group B, n=46) strains were collected from the following countries: Greece, 20; Israel, 93; Italy, 19; USA, 25; and Colombia, 3. Group B included 30 different STs from various lineages. The pilv-l gene was present in 111/114 of ST-258 isolates, including all of the KPC-negative isolates resulting in a sensitivity of 97%. Using primers for a unique ST-258 pilv-l allele resulted in a specificity of 100%. The sensitivity values of is-66 and prp genes for detecting KPC-KP ST-258 were 83 and 89%, respectively, and the specificity values were 67 and 93%, respectively. PCR for the unique pilv-l ST-258 allele provides a reliable tool for rapid detection of the ST-258 clone. This method can be helpful both in the setting of an outbreak and in a large-scale survey of KPC-KP strains.

  4. Result analysis of serum anti-HCV positive combined with HCV-RNA quantitative detection of 258 cases%258例血清中抗-HCV阳性联合HCV-RNA定量检测结果分析

    Institute of Scientific and Technical Information of China (English)

    庞丽娜; 薛金方

    2014-01-01

    目的:探讨丙型肝炎病毒抗体(抗-HCV)和丙型肝炎病毒核糖核酸(HCV-RNA)定量联合检测结果对丙型肝炎确诊的临床意义。方法对258例ELISA法检测的血清抗-HCV阳性丙型肝炎(HC)患者,同时采用PCR-荧光探针法检测其HCV-RNA含量。结果258例抗-HCV阳性丙型肝炎患者中HCV-RNA阴性92例,占35.66%;17例HCV-RNA弱阳性,占6.59%;HCV-RNA阳性149例,即57.75%的HC患者存在病毒血症。结论ELISA法联合检测抗-HCV和HCV-RNA有助于丙型肝炎确诊病毒血症以及监控HCV的感染,并及时进行抗病毒治疗。%Objective To investigate the clinical significance of hepatitis C virus antibody (anti-HCV) combined with hepatitis C virus ribonucleic acid (HCV-RNA) quantitative detection in the diagnosis of hepatitis C (HC).Methods A total of 258 cases of HC with anti-HCV positive were detected by ELISA method and PCR-fluorescence probe for the HCV-RNA content.Results Among the 258 cases with anti-HCV positive, there were 92 cases of HCV-RNA negative as 35.66%, 17 cases of HCV-RNA weakly positive as 6.59%, and 149 cases of HCV-RNA positive. Thus, there were 57.75% of the HC patients with viremia.Conclusion ELISA method in combined detection of anti-HCV and HCV-RNA helps to diagnose viremia of HC, monitor HCV infection and conduct timely antiviral treatment.

  5. Both clades of the epidemic KPC-producing Klebsiella pneumoniae clone ST258 share a modified galactan O-antigen type.

    Science.gov (United States)

    Szijártó, Valéria; Guachalla, Luis Miguel; Hartl, Katharina; Varga, Cecília; Banerjee, Pallavi; Stojkovic, Katarina; Kaszowska, Marta; Nagy, Eszter; Lukasiewicz, Jolanta; Nagy, Gábor

    2016-02-01

    Klebsiella pneumoniae ST258 is a globally disseminated, extremely drug resistant, nosocomial clone with limited treatment options. We show that the vast majority of ST258 isolates express modified d-galactan-I lipopolysaccharide O-antigen, termed hereinafter as D-galactan-III. The genetic determinant required for galactan-III synthesis was identified as a distinct operon adjacent to the rfb (wb) locus encoding D-galactan-I synthesis. The three genes within the operon encode predicted glycosyltransferases. Testing an isogenic transformant pair revealed that expression of D-galactan-III, in comparison to D-galactan-I, conferred improved survival in the presence of human serum. Eighty-three percent of the more than 200 ST258 draft genome sequences currently available carries the corresponding operon and hence these isolates are predicted to express galactan-III antigens. A D-galactan-III specific monoclonal antibody (mAb) was shown to bind to extracted LPS from a panel of ST258 isolates. The same mAb confirmed accessibility of galactan-III in surface staining of ST258 irrespective of the distinct capsular antigens expressed by both clades described previously. Based on these data, the galactan-III antigen may represent an attractive target for active and passive immunization approaches against K. pneumoniae ST258.

  6. Langerhans cell histiocytosis: a clinicopathologic and immunohistochemical analysis of 258 cases%Langerhans细胞组织细胞增生症258例临床病理特征和免疫表型分析

    Institute of Scientific and Technical Information of China (English)

    许霞; 刘卫平; 杨群培; 王威亚; 廖殿英; 赵莎; 毕成峰; 林莉; 闵敏

    2012-01-01

    Objectives To observe the clinicopathologic features of Langerhans cell histiocytosis (LCH),and to evaluate the values of langerin,CD1a and S-100 protein expression in diagnosis of the tumor.Methods Total 258 cases of Langerhans cell histiocytosis in the past 18 years ( from 1992 to 2008 )were collected,morphologic review and immunohistochemical staining were performed. Results In all 258 cases,the ages of patients older than 16 years or younger than 2 years were 126 (48.8%) and 37 ( 14.3% ),respectively,in the remaining 95 (36.8% ) of the cases,the age of the patients ranged from 2 to 16 years.For all of 258 cases,there were 364 diseased sites. Bony lesions accounted for 77.2%(281 cases),especially the skull (112 cases,39.9% ),followed by lymph node (25 cases,6.9% ) and skin ( 14 cases,3.8% ).Clinically,unisystem or unifocal disease was predominant (201 cases,77.9% ),followed by unisystem and muhifocal disease (21 cases, 8.1%), multi-system disease (26 cases,10.1% ),isolated pulmonary LCH (2 cases,0.8% ),and unclassified (8 cases,3.1% ).Histologically,variable number of Langerhans cells was present in 265 samples of 258 cases.Muhinucleated giant cells were found in 166 (62.6% ) of the samples.Eosinophils were the major infiltrating non-neoplastic cells,and eosinophilic abscess was seen in 57 cases (21.5%).Coagulative necrosis and dead bone were detected in 29 ( 10.9% ) and 124 (46.8% ) of the cases,respectively.Immunohistochemically,the expression of S-100 protein,CD1 a and langerin was 99.1% (209/211),100% (206/206) and 98.5% (193/196),respectively,and the sensitivity of them had no statistical difference.Conclusions In this group of LCH cases,the ratio of adult patients is high,but the proportion of multi-organ lesion is low. No significant difference of the sensitivity is found among langerin,CD1a and S-100 expression in diagnosis of LCH.%目的 观察Langerhans细胞组织细胞增生症(LCH)的

  7. Long-Term X-ray Monitoring of 1E 1740.7-2942 and GRS 1758-258

    CERN Document Server

    Main, D S; Heindl, W A; Swank, J H; Leventhal, M; Mirabel, I F; Rodríguez, L F

    1999-01-01

    We report on long-term observations of the Galactic-bulge black hole candidates 1E 1740.7-2942 and GRS 1758-258 with the Rossi X-Ray Timing Explorer. 1E 1740.7-2942 has been observed 77 times and GRS 1758-258 has been observed 82 times over the past 1000 days. The flux of each object has varied by no more than a factor of 2.5 during this period, and the indices of the energy spectra have varied by no more than 0.4. The power spectra are similar to other black-hole candidates: flat-topped noise, breaking to a power law. Each object has exhibited a brightening that lasted for several months, and we have a found a time lag between the photon power-law index and the count rate. In both sources, the spectrum is softest during the decline from the brightening. This behavior can be understood in the context of thin-disk and advection-dominated accretion flows coexisting over a wide range of radii, with the implication that both sources have low-mass companions and accrete via Roche-lobe overflow.

  8. XMM-Newton Spectroscopy of the Galactic Microquasar GRS 1758-258 in the Peculiar Off/Soft State

    Science.gov (United States)

    Miller, J. M.; Wunands, R.; Rodriguez-Pascual, P. M.; Ferrando, P.; Gaensler, B. M.; Goldwurm, A.; Lewin, W. H. G.; Pooley, D.

    2002-01-01

    We report on an XMM-Newton Reflection Grating Spectrometer observation of the black hole candidate and Galactic microquasar GRS 1758-258. The source entered a peculiar "off/soft" state in 2001 late February in which the spectrum softened while the X-ray flux-and the inferred mass accretion rate-steadily decreased. We find no clear evidence for emission or absorption lines in the dispersed spectra, indicating that most of the observed soft flux is likely from an accretion disk and not from a cool plasma. The accretion disk strongly dominates the spectrum in this lower luminosity state and is only mildly recessed from the marginally stable orbit. These findings may be di8licult to explain in terms of advection-dominated accretion flow (ADAF) models. We discuss these results within the context of ADAF models, simultaneous two-flow models, and observed correlations between hard X-ray flux and jet production.

  9. Safety of UV-treated milk as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on UV-treated milk as a novel food submitted pursuant to Regulation (EC) No 258/97, taking into account the comments and objections of a scientific...... of infants (up to 1 year of age). The Panel considers that it is unlikely that tolerable upper intake levels established by EFSA for children aged 1–10 years, adolescents and adults will be exceeded. The Panel considers that the novel food is not nutritionally disadvantageous. The data provided do not give...... rise to concerns with regard to the microbiological quality. The Panel considers that the risk of allergic reactions to the novel food is not dissimilar to that associated with conventional milk. The Panel concludes that the novel food, UV-treated milk, is safe under the intended conditions of use...

  10. Klebsiella pneumoniae Isolate from a New York City Hospital Belonging to Sequence Type 258 and Carrying blaKPC-2 and blaVIM-4.

    Science.gov (United States)

    Castanheira, Mariana; Deshpande, Lalitagauri M; Mills, Janet C; Jones, Ronald N; Soave, Rosemary; Jenkins, Stephen G; Schuetz, Audrey N

    2016-01-04

    Among 69 of 139 (49.6%) carbapenem-nonsusceptible Enterobacteriaceae carrying blaKPC, 1 Klebsiella pneumoniae was also positive for blaVIM. The isolate belonged to sequence type 258 (ST258) and carried blaKPC-2 on a copy of Tn4401a and blaVIM-4 on a class 1 integron. Genes were located on distinct plasmids belonging to Inc types A/C and FII. Elevated expression of the efflux pump AcrAB-TolC (acrA, 15.3 times) and reduced expression of outer membrane protein genes ompK35 and ompK37 (0.16 and 0.081 times, respectively) associated with various amino acid alterations on OmpK37 were observed. The presence of two carbapenemases in ST258 K. pneumoniae is of great concern due to the ability of this organism to widely disseminate.

  11. Diversity of capsular polysaccharide gene clusters in Kpc-producing Klebsiella pneumoniae clinical isolates of sequence type 258 involved in the Italian epidemic.

    Science.gov (United States)

    D'Andrea, Marco Maria; Amisano, Francesco; Giani, Tommaso; Conte, Viola; Ciacci, Nagaia; Ambretti, Simone; Santoriello, Luisa; Rossolini, Gian Maria

    2014-01-01

    Strains of Klebsiella pneumoniae producing KPC-type beta-lactamases (KPC-Kp) are broadly disseminating worldwide and constitute a major healthcare threat given their extensively drug resistant phenotypes and ability to rapidly disseminate in healthcare settings. In this work we report on the characterization of two different capsular polysaccharide (CPS) gene clusters, named cpsBO-4 and cps207-2, from two KPC-Kp clinical strains from Italy belonging in sequence type (ST) 258, which is one of the most successful ST of KPC-Kp spreading worldwide. While cpsBO-4 was different from known 78 K-types according to the recently proposed typing schemes based on the wzi or wzc gene sequences, cps207-2 was classified as K41 by one of these methods. Bioinformatic analysis revealed that they were represented in the genomic sequences of KPC-Kp from strains of ST258 from different countries, and cpsBO-4 was also detected in a KPC-Kp strain of ST442 from Brazil. Investigation of a collection of 46 ST258 and ST512 (a single locus variant of ST258) clinical strains representative of the recent Italian epidemic of KPC-Kp by means of a multiplex PCR typing approach revealed that cpsBO-4 was the most prevalent type, being detected both in ST258 and ST512 strains with a countrywide distribution, while cps207-2 was only detected in ST258 strains with a more restricted distribution.

  12. Diversity of Capsular Polysaccharide Gene Clusters in Kpc-Producing Klebsiella pneumoniae Clinical Isolates of Sequence Type 258 Involved in the Italian Epidemic

    Science.gov (United States)

    D’Andrea, Marco Maria; Amisano, Francesco; Giani, Tommaso; Conte, Viola; Ciacci, Nagaia; Ambretti, Simone; Santoriello, Luisa; Rossolini, Gian Maria

    2014-01-01

    Strains of Klebsiella pneumoniae producing KPC-type beta-lactamases (KPC-Kp) are broadly disseminating worldwide and constitute a major healthcare threat given their extensively drug resistant phenotypes and ability to rapidly disseminate in healthcare settings. In this work we report on the characterization of two different capsular polysaccharide (CPS) gene clusters, named cpsBO-4 and cps207-2, from two KPC-Kp clinical strains from Italy belonging in sequence type (ST) 258, which is one of the most successful ST of KPC-Kp spreading worldwide. While cpsBO-4 was different from known 78 K-types according to the recently proposed typing schemes based on the wzi or wzc gene sequences, cps207-2 was classified as K41 by one of these methods. Bioinformatic analysis revealed that they were represented in the genomic sequences of KPC-Kp from strains of ST258 from different countries, and cpsBO-4 was also detected in a KPC-Kp strain of ST442 from Brazil. Investigation of a collection of 46 ST258 and ST512 (a single locus variant of ST258) clinical strains representative of the recent Italian epidemic of KPC-Kp by means of a multiplex PCR typing approach revealed that cpsBO-4 was the most prevalent type, being detected both in ST258 and ST512 strains with a countrywide distribution, while cps207-2 was only detected in ST258 strains with a more restricted distribution. PMID:24823690

  13. Diversity of capsular polysaccharide gene clusters in Kpc-producing Klebsiella pneumoniae clinical isolates of sequence type 258 involved in the Italian epidemic.

    Directory of Open Access Journals (Sweden)

    Marco Maria D'Andrea

    Full Text Available Strains of Klebsiella pneumoniae producing KPC-type beta-lactamases (KPC-Kp are broadly disseminating worldwide and constitute a major healthcare threat given their extensively drug resistant phenotypes and ability to rapidly disseminate in healthcare settings. In this work we report on the characterization of two different capsular polysaccharide (CPS gene clusters, named cpsBO-4 and cps207-2, from two KPC-Kp clinical strains from Italy belonging in sequence type (ST 258, which is one of the most successful ST of KPC-Kp spreading worldwide. While cpsBO-4 was different from known 78 K-types according to the recently proposed typing schemes based on the wzi or wzc gene sequences, cps207-2 was classified as K41 by one of these methods. Bioinformatic analysis revealed that they were represented in the genomic sequences of KPC-Kp from strains of ST258 from different countries, and cpsBO-4 was also detected in a KPC-Kp strain of ST442 from Brazil. Investigation of a collection of 46 ST258 and ST512 (a single locus variant of ST258 clinical strains representative of the recent Italian epidemic of KPC-Kp by means of a multiplex PCR typing approach revealed that cpsBO-4 was the most prevalent type, being detected both in ST258 and ST512 strains with a countrywide distribution, while cps207-2 was only detected in ST258 strains with a more restricted distribution.

  14. Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.

    Science.gov (United States)

    Arena, Fabio; Henrici De Angelis, Lucia; Cannatelli, Antonio; Di Pilato, Vincenzo; Amorese, Marina; D'Andrea, Marco Maria; Giani, Tommaso; Rossolini, Gian Maria

    2016-04-01

    Using aGalleria mellonellaanimal model, we compared the virulence of two sequence type 258 (ST258) KPC-producingKlebsiella pneumoniaestrains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistantmgrBmutants. With both strains, themgrBmutants did not exhibit modification in virulence. In theG. mellonellamodel, the clade 1 strain (capsular typecps-1[wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular typecps-2[wzi154, producing KPC-3]).

  15. The Clinical Ddiagnosis and Research on 258 Cases of Tuberculous Pleuritis%258例结核性胸膜炎的临床诊断和治疗研究

    Institute of Scientific and Technical Information of China (English)

    赵艳民

    2011-01-01

    目的 探讨本区域的结核性胸膜炎的临床表现,及时掌握患者的临床特征,进一步提高诊治水平.方法 对我所收治的258例结核性胸膜炎患者的临床资料和治疗措施进行回顾性分析.结果 经系统治疗245例好转,其中毒症状基本消失、胸水吸收,坚持抗结核治疗,痊愈者126例;4例因合并其他危重病症死亡,9例自动出院.结论 及早的进行规范、适量及全程化疗,同时尽早抽放胸水能够提高治愈率,同时能够防治预后胸膜肥厚、粘连.

  16. Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases.

    Science.gov (United States)

    Castronovo, Giuseppe; Clemente, Ann Maria; Antonelli, Alberto; D'Andrea, Marco Maria; Tanturli, Michele; Perissi, Eloisa; Paccosi, Sara; Parenti, Astrid; Cozzolino, Federico; Rossolini, Gian Maria; Torcia, Maria Gabriella

    2017-01-01

    ST258-K. pneumoniae (ST258-KP) strains, the most widespread multidrug-resistant hospital-acquired pathogens, belong to at least two clades differing in a 215 Kb genomic region that includes the cluster of capsule genes. To investigate the effects of the different capsular phenotype on host-pathogen interactions, we studied representatives of ST258-KP clades, KKBO-1 and KK207-1, for their ability to activate monocytes and myeloid dendritic cells from human immune competent hosts. The two ST258-KP strains strongly induced the production of inflammatory cytokines. Significant differences between the strains were found in their ability to induce the production of IL-1β: KK207-1/clade I was much less effective than KKBO-1/clade II in inducing IL-1β production by monocytes and dendritic cells. The activation of NLRP3 inflammasome pathway by live cells and/or purified capsular polysaccharides was studied in monocytes and dendritic cells. We found that glibenclamide, a NLRP3 inhibitor, inhibits more than 90% of the production of mature IL-1β induced by KKBO1 and KK207-1. KK207-1 was always less efficient compared to KKBO-1 in: a) inducing NLRP3 and pro-IL-1β gene and protein expression; b) in inducing caspase-1 activation and pro-IL-1β cleavage. Capsular composition may play a role in the differential inflammatory response induced by the ST258-KP strains since capsular polysaccharides purified from bacterial cells affect NLRP3 and pro-IL-1β gene expression through p38MAPK- and NF-κB-mediated pathways. In each of these functions, capsular polysaccharides from KK207-1 were significantly less efficient compared to those purified from KKBO-1. On the whole, our data suggest that the change in capsular phenotype may help bacterial cells of clade I to partially escape innate immune recognition and IL-1β-mediated inflammation.

  17. Charge state distributions and charge exchange cross sections of carbon in helium at 30-258 keV

    Science.gov (United States)

    Maxeiner, Sascha; Seiler, Martin; Suter, Martin; Synal, Hans-Arno

    2015-10-01

    With the introduction of helium stripping in radiocarbon (14C) accelerator mass spectrometry (AMS), higher +1 charge state yields in the 200 keV region and fewer beam losses are observed compared to nitrogen or argon stripping. To investigate the feasibility of even lower beam energies for 14C analyses the stripping characteristics of carbon in helium need to be further studied. Using two different AMS systems at ETH Zurich (myCADAS and MICADAS), ion beam transmissions of carbon ions for the charge states -1, +1, +2 and +3 were measured in the range of 258 keV down to 30 keV. The correction for beam losses and the extraction of charge state yields and charge exchange cross sections will be presented. An increase in population of the +1 charge state towards the lowest measured energies up to 75% was found as well as agreement with previous data from literature. The findings suggest that more compact radiocarbon AMS systems are possible and could provide even higher efficiency than current systems operating in the 200 keV range.

  18. Rotationally resolved water dimer spectra in atmospheric air and pure water vapour in the 188-258 GHz range.

    Science.gov (United States)

    Serov, E A; Koshelev, M A; Odintsova, T A; Parshin, V V; Tretyakov, M Yu

    2014-12-21

    New experimental results regarding "warm" water dimer spectra under equilibrium conditions are presented. An almost equidistant series of six peaks corresponding to the merged individual lines of the bound dimer with consecutive rotational quantum numbers is studied in the 188-258 GHz frequency range in water vapour over a broad range of pressures and temperatures relevant to the Earth's atmosphere. The series is a continuation of the sequence detected earlier at lower frequencies at room temperature. The signal-to-noise ratio of the observed spectra allowed investigating their evolution, when water vapour was diluted by atmospheric air with partial pressure from 0 up to 540 Torr. Analysis of the obtained spectra permitted determining the dimerization constant as well as the hydrogen bond dissociation energy and the dimer spectral parameters, including the average coefficient of collisional broadening of individual lines by water vapour and air. The manifestation of metastable states of the dimer in the observed spectra is assessed. The contribution of three possible pair states of water molecules to the second virial coefficient is evaluated over the broad range of temperatures. The work supports the significant role of the water dimer in atmospheric absorption and related processes.

  19. Star formation in the filament of S254-S258 OB complex: a cluster in the process of making

    CERN Document Server

    Samal, M R; Jose, J; Zavagno, A; Takahashi, S; Neichel, B; Kim, J S; Chauhan, N; Pandey, A K; Zinchenko, I; Tamura, M; Ghosh, S K

    2015-01-01

    Infrared Dark Clouds are ideal laboratories to study the initial processes of high-mass star and star cluster formation. We investigated star formation activity of an unexplored filamentary dark cloud (~5.7pc x 1.9pc), which itself is part of a large filament (~20pc) located in the S254-S258 OB complex at a distance of 2.5kpc. Using MIPS Spitzer 24 micron data, we uncover 49 sources with SNR greater than 5. We identified 45 sources as candidate YSOs of Class I, Flat-spectrum & Class II nature. Additional 17 candidate YSOs (9 Class I & 8 Class II) are also identified using JHK and WISE photometry. We find that the protostar to Class II sources ratio (~2) and the protostar fraction (~70%) of the region are high. When the protostar fraction compared to other young clusters, it suggests that the star formation in the dark cloud was possibly started only 1 Myr ago. Combining the NIR photometry of the YSO candidates with the theoretical evolutionary models, we infer that most of the candidate YSOs formed in...

  20. Effect evaluation of health education and system management of 258 cases of diabetic patients%258例糖尿病患者健康教育与系统管理的效果评价

    Institute of Scientific and Technical Information of China (English)

    于占君

    2014-01-01

    目的:通过对糖尿病患者的健康教育与系统管理,观察患者血糖控制效果。方法随机抽取2012年1月~2013年6月在我院住院实施健康教育与系统管理的258例糖尿病患者,比较健康教育与系统管理前后患者糖尿病知识掌握、行为改变和血糖、糖化血红蛋白监测值的变化情况。结果实施健康教育与系统管理后达到长期对患者进行护理干预,使糖尿病患者知识掌握和建立健康行为(饮食控制、适当运动、自我监测血糖、遵医用药)较教育与系统管理前人数明显增加,差异有统计学意义(P<0.05);教育与系统管理后患者血糖值和糖化血红蛋白值明显低于教育与系统管理前,差异有统计学意义(P<0.05)。结论健康教育与系统管理可使糖尿病患者建立健康行为,逐渐形成良好习惯,提高自我管理能力,有效控制血糖水平,防止并发症的发生和发展,提高生活质量。%Objective To observe the effect of blood glucose control through the health education and management for patients with diabetes mellitus. Methods A total of 258 cases of diabetes patients were selected in our hospital from January 2012 to June 2013, and implementing the systematic management and the education of health for patients. The diabetic knowledge, behavior changes, the changes of blood glucose and glycosylated hemoglobin value of these pa-tients before and after the education and system management were compared and analyzed. Results The implementation of health education and system management can achieve long-term nursing intervention for patients before and after education and management, the number of diabetic patients increases significantly who had diabetic knowledge and healthy behaviors (e.g. diet control, proper exercises, self-monitoring of blood glucose, according to medical medicine),and the difference was statistically significant (P<0.05). The values of blood

  1. One-center bone tumors in the foot:an epidemiological analysis of 258 cases%单中心足部骨肿瘤258例临床流行病学分析

    Institute of Scientific and Technical Information of China (English)

    廖锋; 徐海荣; 牛晓辉

    2015-01-01

    目的:探究足部骨肿瘤流行病学特点。方法回顾1957年8月至2014年7月,北京积水潭医院骨肿瘤科诊治的258例足部骨肿瘤患者资料,分析其性别、年龄、病理诊断、发病部位及影像特点。结果男174例,女84例,年龄7~76岁,平均27.9岁。病变多位于跟骨、趾骨、距骨、跖骨,少见于足舟骨、楔骨和骰骨。恶性骨肿瘤38例,包括软骨肉瘤13例、骨肉瘤8例、Ewing 肉瘤6例、转移性肿瘤5例;中间型肿瘤81例,包括软骨母细胞瘤36例、骨巨细胞瘤29例、动脉瘤样骨囊肿10例、软骨粘液样纤维瘤3例;良性肿瘤139例,包括内生软骨瘤37例、甲下外生性骨疣27例、单纯性骨囊肿26例、骨软骨瘤19例、骨样骨瘤12例、骨脂肪瘤10例。结论足部骨肿瘤好发于中青年男性,多为良性或中间型。%Objective To explore epidemiological features of bone tumors in the foot and further to guide clinical diagnosis.Methods From August 1957 to July 2014, 258 patients were included. Gender, age, location, pathological and radiological data were reviewed.Results There were 174 males and 84 females, with a mean age of 27.9 years ( range: 7-76 years ). Bone tumors of the foot had particular predilections in the calcaneus, talus, phalanx and metatarsal bones. Thirty-eight cases of malignant tumors included chondrosarcoma ( 13 cases ), osteosarcoma ( 8 cases ), Ewing sarcoma ( 6 cases ) and metastatic tumors ( 5 cases ). Eighty-one cases of intermediate bone tumors included chondroblastoma ( 36 cases ), giant cell tumors of bone ( 29 cases ), aneurysmal bone cysts ( 10 cases ) and chondromyxoid ifbroma ( 3 cases ). One hundred and thirty-nine benign bone tumors included enchondroma ( 37 cases ), subungual exostosis ( 27 cases ), simple bone cyst ( 26 cases ), osteochondroma ( 19 cases ), osteoid osteoma ( 12 cases ) and lipoma of bone ( 10 cases ).Conclusions Benign and intermediate tumors are most common in

  2. Rapid expansion of KPC-2-producing Klebsiella pneumoniae isolates in two Texas hospitals due to clonal spread of ST258 and ST307 lineages.

    Science.gov (United States)

    Castanheira, Mariana; Farrell, Sarah E; Wanger, Audrey; Rolston, Kenneth V; Jones, Ronald N; Mendes, Rodrigo E

    2013-08-01

    During 2007 to 2010, 23 carbapenem-resistant Enterobacteriaceae strains were recovered in two hospitals in Texas among three institutions surveyed. Eighteen (2.0% overall) strains carried bla(KPC-2) and were collected in 2008 (3/150; 2.0%) and 2010 (15/289; 5.1%). Clonality was noted within hospitals and ten isolates belonged to ST258. All strains carried bla(KPC-2) on plasmids and 14 had this gene embedded in Tn4401a. Tn3 transposase was detected upstream of bla(KPC-2) in two isolates and another strain had two adjacent copies of bla(KPC). Surveillance in prior years shows sporadic detection of KPC-producers in Texas, however, a recent increase in carbapenem-resistant Enterobacteriaceae in this state was due to the spread of KPC-producing Klebsiella pneumoniae, including isolates from ST258.

  3. Arthrolysis for 258 cases of post-traumatic elbow stiffmess%肘关节松解术治疗创伤后肘关节僵硬:附258例报告

    Institute of Scientific and Technical Information of China (English)

    公茂琪; 查晔军; 刘兴华; 张力丹; 蒋协远

    2012-01-01

    Objective To analyze functional recovery and complications in patients undergoing arthrolysis for post-traumatic elbow stiffness. Methods From April 2007 to April 2011,306 cases of stiff elbow were treated by the same treating team.Of them,258,166 men and 92 women,were fully followed up.Their average age was 36.7 years old.The stiff elbow was on the left in 142 cases,on the right in 116 cases,on the dominant side in 119 cases and on the nondominant side in 139 cases.They were treated with sole arthrolysis or arthrolysis combined with hinged external fixators according to specific conditions.Based on the original approaches used and specific causes of elbow stiffness we adopted the medial,lateral,posterior or medial combined with lateral approaches. Results The average follow-up time was 12.0 months (from 6 to 48 months).Arthrolysis combined with hinged external fixators was performed in 213 cases,with a mean time of external fixation of 7.7 weeks (from 5 to 11 weeks).Sole arthrolysis was performed in the other 45 cases.The mean range of motion (ROM) in extension and flexion was improved by 53.9° ± 36.0° (0° to140°),from preoperative 42.4° ± 31.1 ° (0° to 90°) to peostoperative 96.2° ± 18.2° (60° to 140°) ; the mean pronation and supination was improved by 24.4° ± 33.4° (0° to 110°),from preoperative 136.8 ± 49.1 ° ( 10° to 180°) to postoperative 161.2°± 22.2° (120° to 180°).The mean Mayo Elbow Performance Score (MEPS) was improved by 20.0 ± 17.1 points (0 to 40 points),from preoperative 71.5 ± 15.3 points (60 to 100 points) to postoperative 91.6 ± 7.3 points (85 to 100 points). There were significant differences between preoperation and postoperation in all the indexes above ( P < 0.05).Hematoma at the posterior elbow,wound dehiscence,pin hole infection,external fixator breakage and nerve lesions were observed in 95 patients postoperatively. Conclusions As long as preoperative appraisal of the condition is precise and operative

  4. An Update of the Evolving Epidemic of blaKPC Carrying Klebsiella pneumoniae in Sicily, Italy, 2014: Emergence of Multiple Non-ST258 Clones.

    Directory of Open Access Journals (Sweden)

    Celestino Bonura

    Full Text Available In Italy, Klebsiella pneumoniae carbapenemase producing K. pneumoniae (KPC-Kp strains are highly endemic and KPC producing CC258 is reported as the widely predominating clone. In Palermo, Italy, previous reports have confirmed this pattern. However, recent preliminary findings suggest that an epidemiological change is likely ongoing towards a polyclonal KPC-Kp spread. Here we present the results of molecular typing of 94 carbapenem non susceptible K. pneumoniae isolates detected during 2014 in the three different hospitals in Palermo, Italy.Ninety-four consecutive, non replicate carbapenem non susceptible isolates were identified in the three largest acute general hospitals in Palermo, Italy, in the six-month period March-August 2014. They were characterized by PCR for β-lactam, aminoglycoside and plasmid mediated fluoroquinolone resistance genetic determinants. The mgrB gene of the colistin resistant isolates was amplified and sequenced. Clonality was assessed by pulsed field gel electrophoresis and multilocus sequence typing. Eight non-CC258 sequence types (STs were identified accounting for 60% of isolates. In particular, ST307 and ST273 accounted for 29% and 18% of isolates. CC258 isolates were more frequently susceptible to gentamicin and non-CC258 isolates to amikacin. Colistin non susceptibility was found in 42% of isolates. Modifications of mgrB were found in 32 isolates.Concurrent clonal expansion of some STs and lateral transmission of genetic resistance determinants are likely producing a thorough change of the KPC-Kp epidemiology in Palermo, Italy. In our setting mgrB inactivation proved to substantially contribute to colistin resistance. Our findings suggest the need to continuously monitor the KPC-Kp epidemiology and to assess by a nationwide survey the possible shifting towards a polyclonal epidemic.

  5. Draft Genome Sequence of a Hospital-Associated Clone of Klebsiella pneumoniae ST340/CC258 Coproducing RmtG and KPC-2 Isolated from a Pediatric Patient.

    Science.gov (United States)

    Cerdeira, Louise; Fernandes, Miriam R; Francisco, Gabriela R; Bueno, Maria Fernanda C; Ienne, Susan; Souza, Tiago A; de Oliveira Garcia, Doroti; Lincopan, Nilton

    2016-11-03

    We report here the draft genome sequence of a Klebsiella pneumoniae strain 1194/11, belonging to the hospital-associated sequence type 340 (ST340; clonal complex CC258), isolated from a catheter tip culture from a pediatric patient. The multidrug-resistant strain coproduced the 16S rRNA methyltransferase rRNA RmtG and β-lactamases KPC-2 and CTX-M-15.

  6. Laparoscopic Versus Open Hysterectomy for Benign Disease in Uteri Weighing >1 kg: A Retrospective Analysis on 258 Patients.

    Science.gov (United States)

    Uccella, Stefano; Morosi, Chiara; Marconi, Nicola; Arrigo, Anna; Gisone, Baldo; Casarin, Jvan; Pinelli, Ciro; Borghi, Camilla; Ghezzi, Fabio

    2017-07-12

    To present a large single-center series of hysterectomies for uteri ≥1 kg and to compare the laparoscopic and open abdominal approach in terms of perioperative outcomes and complications. A retrospective analysis of prospectively collected data (Canadian Task Force classification II-2). An academic research center. Consecutive women who underwent hysterectomy for uteri ≥1 kg between January 2000 and December 2016. Patients with a preoperative diagnosis of uterine malignancy or suspected uterine malignancy were excluded. The subjects were divided according to the intended initial surgical approach (i.e., open or laparoscopic). The 2 groups were compared in terms of intraoperative data and postoperative outcomes. Multivariable analysis was performed to identify possible independent predictors of overall complications. A subanalysis including only obese women was accomplished. Total laparoscopic versus abdominal hysterectomy (±bilateral adnexectomy). Intra- and postoperative surgical outcomes. A total of 258 patients were included; 55 (21.3%) women were initially approached by open surgery and 203 (78.7%) by laparoscopy. Nine (4.4%) conversions from laparoscopic to open surgery were registered. The median operative time was longer in the laparoscopic group (120 [range, 50-360] vs 85 [range, 35-240] minutes, p = .014). The estimated blood loss (150 [range, 0-1700] vs 200 [50-3000] mL, p = .04), postoperative hemoglobin drop, and hospital stay (1 [range, 1-8] vs 3 [range, 1-8] days, p laparoscopic approach was found to be the only independent predictor of a lower incidence of overall complications (odds ratio = 0.42; 95% confidence interval, 0.19-0.9). The overall morbidity of minimally invasive hysterectomy was lower also in the subanalysis concerning only obese patients. In experienced hands and in dedicated centers, laparoscopic hysterectomy for uteri weighing ≥1 kg is feasible and safe. Minimally invasive surgery retains its well

  7. Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases

    Science.gov (United States)

    Antonelli, Alberto; D’Andrea, Marco Maria; Tanturli, Michele; Perissi, Eloisa; Paccosi, Sara; Parenti, Astrid; Cozzolino, Federico; Rossolini, Gian Maria

    2017-01-01

    ST258-K. pneumoniae (ST258-KP) strains, the most widespread multidrug-resistant hospital-acquired pathogens, belong to at least two clades differing in a 215 Kb genomic region that includes the cluster of capsule genes. To investigate the effects of the different capsular phenotype on host-pathogen interactions, we studied representatives of ST258-KP clades, KKBO-1 and KK207-1, for their ability to activate monocytes and myeloid dendritic cells from human immune competent hosts. The two ST258-KP strains strongly induced the production of inflammatory cytokines. Significant differences between the strains were found in their ability to induce the production of IL-1β: KK207-1/clade I was much less effective than KKBO-1/clade II in inducing IL-1β production by monocytes and dendritic cells. The activation of NLRP3 inflammasome pathway by live cells and/or purified capsular polysaccharides was studied in monocytes and dendritic cells. We found that glibenclamide, a NLRP3 inhibitor, inhibits more than 90% of the production of mature IL-1β induced by KKBO1 and KK207-1. KK207-1 was always less efficient compared to KKBO-1 in: a) inducing NLRP3 and pro-IL-1β gene and protein expression; b) in inducing caspase-1 activation and pro-IL-1β cleavage. Capsular composition may play a role in the differential inflammatory response induced by the ST258-KP strains since capsular polysaccharides purified from bacterial cells affect NLRP3 and pro-IL-1β gene expression through p38MAPK- and NF-κB-mediated pathways. In each of these functions, capsular polysaccharides from KK207-1 were significantly less efficient compared to those purified from KKBO-1. On the whole, our data suggest that the change in capsular phenotype may help bacterial cells of clade I to partially escape innate immune recognition and IL-1β-mediated inflammation. PMID:28081233

  8. Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population

    Directory of Open Access Journals (Sweden)

    Okada Rieko

    2011-03-01

    Full Text Available Abstract Background Although SLC22A12 258X allele was found among those with hypouricemia, it was unknown that serum uric acid distribution among those with SLC22A12 258X allele. This study examined serum uric acid (SUA distribution according to SLC22A12 W258X genotype in a general Japanese population. Methods Subjects were 5,023 health checkup examinees (3,413 males and 1,610 females aged 35 to 69 years with creatinine SLC22A12 W258X was genotyped with a polymerase chain reaction with confronting two-pair primers. Results The genotype frequency was 4,793 for WW, 225 for WX, and 5 for XX, which was in Hardy-Weinberg equilibrium (p = 0.164 with X allele 0.023 (95% confidence interval [0.021-0.027]. Mean (range SUA was 6.2 (2.1-11.4 mg/dL for WW, 3.9 (0.8-7.8 mg/dL for WX, and 0.8 (0.7-0.9 mg/dL for XX among males, and 4.5 (1.9-8.9 mg/dL, 3.3 (2.0-6.5 mg/dL, and 0.60 (0.5-0.7 mg/dL among females, respectively. Six individuals with SUA less than 1.0 mg/dL included two males with XX genotype, one male with WX genotype, and three females with XX genotype. Subjects with WX genotype were 14 (77.8% of 18 males with a SUA of 1.0-2.9 mg/dL, and 28 (34.6% of 81 females with the same range of SUA. The corresponding values were 131 (25.1% of 522 males and 37 (3.5% of 1,073 females for SUA 3.0-4.9 mg/dL, and 8 (0.4% of 2,069 males and 5 (1.1% of 429 females for SUA 5.0-6.9 mg/dL. The X allele effect for SUA less than 3 mg/dL was significantly (p Conclusions Although SLC22A12 W258X was a determining genetic factor on SUA, SUA of those with WX genotype distributed widely from 0.8 mg/dL to 7.8 mg/dL. It indicated that other genetic traits and/or lifestyle affected SUA of those with WX genotype, as well as those with WW genotype.

  9. Kinetics of heterogeneous reactions of ozone with representative PAHs and an alkene at the air-ice interface at 258 and 188 K.

    Science.gov (United States)

    Ray, D; Lišková, H; Klán, P

    2014-04-01

    The kinetics of the reaction of an alkene (E-stilbene) and three polycyclic aromatic hydrocarbons (perylene, anthracene and fluoranthene), as examples of environmental pollutants, with ozone on the surface of ice grains (also called "artificial snow"), produced by shock-freezing of aqueous solutions, was studied at submonolayer pollutant coverages (c = 1.5 × 10(-8) to 3 × 10(-10) mol kg(-1)) and two different temperatures (258 and 188 K). This work supports and extends our previous discovery of a remarkable increase in the apparent ozonation rates with decreasing temperature. The ozonation kinetic results were evaluated using the Langmuir-Hinshelwood model and, in one case, the Eley-Rideal kinetic model. It is shown that the apparent rate enhancement is related to the specific nature of the ice surface at different temperatures, which influences the availability of contaminants to gaseous ozone, and to inherent reactivities of the contaminants. The maximum pseudofirst-order rate constants and the lifetimes of the studied compounds are provided. At a typical atmospheric ozone concentration in polar areas (50 ppbv), the lifetimes were estimated to be on the order of hours (258 K) or tens of minutes (188 K) for alkenes, and hundreds (258 K) or tens (188 K) of days for PAHs, thus approximately of the same magnitude or longer than those found for the gas-phase reactions. We imply that this rate enhancement at lower temperatures is a general phenomenon, and we provide data to implement heterogeneous reactions in snow in models that predict the extent of chemical reactions occurring in cold environments.

  10. Scientific opinion on the safety of synthetic L-ergothioneine (Ergoneine®) as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on synthetic l-ergothioneine, marketed as Ergoneine®, as a novel food submitted pursuant to Regulation (EC) No 258/97 of the European...... concerns. The applicant intends to use the novel food in quantities of up to 5 mg per serving in alcohol-free beverages, cereal bars, milk, fresh dairy products and chocolate. The applicant also proposes to provide the novel food as a food supplement, with a daily dose of up to 30 mg/day for adults and 20...

  11. Scientific Opinion on the safety of alginate-konjac-xanthan polysaccharide complex (PGX) as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    is an off-white granular powder composed of three non-starch polysaccharides: konjac glucomannan, xanthan gum and sodium alginate. The information provided on the composition, the specifications, the batch-to-batch variability and the stability of the NF is sufficient and does not raise safety concerns......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on alginate-konjac-xanthan polysaccharide complex (PGX) as a novel food (NF) submitted pursuant to Regulation (EC) No 258/97. The NF...

  12. Comments on "Sorption of triazoles to soil and iron minerals" by Y. Jia et al. [Chemosphere 67 (2007) 250-258].

    Science.gov (United States)

    Noubactep, C

    2008-03-01

    This letter suggests possible improvements on the discussion of the adsorptive removal of triazoles by iron minerals which are possible corrosion products of elemental iron materials (Fe0) in a recent article by Jia et al. [Jia, Y., Aagaard, P., Breedveld, G.D., 2007. Sorption of triaxoles to soil and iron materials. Chemosphere 67, 250-258]. Also recalled is the importance of the adsorption of organics by iron corrosion products which is not properly addressed in the iron technology literature when the contaminants are redox-sensitive.

  13. Revealing the "missing" low-mass stars in the S254-S258 star forming region by deep X-ray imaging

    CERN Document Server

    Mucciarelli, Paola; Zinnecker, Hans

    2011-01-01

    (abbreviated) In the central part of the S254-S258 star forming complex, a dense embedded cluster of very young stellar objects (S255-IR) is sandwiched between the two HII regions S255 and S257. This interesting configuration had led to different speculations such as dynamical ejection of the B-stars from the central cluster or triggered star formation in a cloud that was swept up in the collision zone between the two expanding HII regions. The presence or absence of low-mass stars associated with these B-stars can discriminate between the possible scenarios. We performed a deep Chandra X-ray observation of the S254-S258 region in order to efficiently discriminate young stars from the numerous older field stars in the area. We detected 364 X-ray point sources, providing a complete sample of all young stars in the observed region down to ~0.5 Msun. A clustering analysis identifies three significant clusters, containing 64 X-ray sources in total. After accounting for X-ray background contaminants, this implies ...

  14. L x-ray production cross sections in Th and U at 17.8, 25.8 and 46.9 keV photon energies

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Ajay; Shahi, J.S.; Mehta, D.; Singh, Nirmal [Department of Physics, Panjab University, Chandigarh (India); Puri, Sanjiv [Department of Physics, SLIET, Longowal (India); Garg, M.L. [Department of Biophysics, Panjab University, Chandigarh (India)

    2001-02-28

    The L x-ray production (XRP) differential cross sections in Th and U have been measured at the 17.8 keV incident photon energy (E{sub L3}25.8 and 46.9 keV incident photon energies (E{sub L1}25.8 and 46.9 keV photon energies, deduced assuming isotropic emission of the L x-rays, are found to be in good agreement with those evaluated using the most reliable theoretical values of L{sub i} (i=1,2,3) subshell photoionization cross sections, fluorescence yields, x-ray emission rates and Coster-Kronig transition probabilities. (author)

  15. Parkin基因启动子区-258T/G多态性与广西地区散发性帕金森病的相关性分析%Association Analysis of the Parkin Gene Promoter-258T/G Polymorphism with Sporadic Parkinson's Disease in Guangxi Province

    Institute of Scientific and Technical Information of China (English)

    窦霄云; 沈岳飞; 林慧琼; 季米娜; 谭建强; 华荣; 胡启平; 方玲; 袁志刚

    2009-01-01

    目的 探讨广西地区parkin基因启动子区-258T/G多态性与散发性帕金森病(sporadicParkinson's disease,SPD)的相关性及该多态性与PD发病年龄的关系.方法 PCR-RFLP及DNA测序等技术,分析parkin基因-258T/G多态性在PD患者和健康对照者间分布频率的差异.结果 PD组parkin基因-258T/G多态性位点G等位基因频率显著高于正常对照组(55.20%:43.33%,x2=6.898,P<0.05,OR=1.61,95%CI:1.13~2.30);GG基因型频率显著高于对照组(28.00%:18.33%,x2=7.159,P<0.05,OR=2.75,95%CI:1.31-5.77).同时,TG+GG基因型频率亦显著高于对照组(82.40%:68.33%,x2=6.551,P<0.05,OR=2.17,95%CI:1.20~3.93).50岁及50岁以上发病患者G等位基因频率和GG基因型频率显著高于对照组,50岁以下发病患者各频率虽高于正常对照组但差异无统计学意义.结论 Parkin基因核心启动子区-258T/G多态G等位基因可能增加了广西地区PD发病风险,且与PD发病年龄成正相关.%Objective To investigate the association between the-258T/G polymorphism.in the pro-moter of parkin gene and the risk for sporadic parkinson's disease (SPD) in Guangxi Province, and in relationto the age of onset, of PD patients. Methods PCR-RFLP and sequence analysis were used to determine thegenotype of-258T/G polymorphism between all patients and healthy controls. Results The G allele was morecommon in patients than controls (55.20%:43.33% ,x2=6.898, P<0.05, OR=1.61, 95% CI: 1.13 ~2.30). The frequency of GG genotype was higher in patients than in controls (28.00 %: 18.33%, x2=7.159, P<0.05, OR=2.75, 95% CI : 1.31 ~ 5.77). The frequency of TG + GG genotype was higher in pa-tients than in controls (82.40%:68.33%, x2=6.551, P<0.05, OR=2.17.95%CI: 1.20 ~3.93). Afterbeing stratified by onset age, the frequencies of the G allele and GG genotype were significantly higher in pa-tients with onset age over 50 years than those in controls respectively. On the other hand, the frequency was notsignificantly different

  16. Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains.

    Directory of Open Access Journals (Sweden)

    Gretchen Meinke

    2016-01-01

    Full Text Available The replication of human polyomavirus JCV, which causes Progressive Multifocal Leukoencephalopathy, is initiated by the virally encoded T-antigen (T-ag. The structure of the JC virus T-ag origin-binding domain (OBD was recently solved by X-ray crystallography. This structure revealed that the OBD contains a C-terminal pocket, and that residues from the multifunctional A1 and B2 motifs situated on a neighboring OBD molecule dock into the pocket. Related studies established that a mutation in a pocket residue (F258L rendered JCV T-ag unable to support JCV DNA replication. To establish why this mutation inactivated JCV T-ag, we have solved the structure of the F258L JCV T-ag OBD mutant. Based on this structure, it is concluded that the structural consequences of the F258L mutation are limited to the pocket region. Further analyses, utilizing the available polyomavirus OBD structures, indicate that the F258 region is highly dynamic and that the relative positions of F258 are governed by DNA binding. The possible functional consequences of the DNA dependent rearrangements, including promotion of OBD cycling at the replication fork, are discussed.

  17. Complementation of a defect in the asparagine-linked glycosylation of a mouse FM3A mutant G258 cell line by spheroplast fusion of a human mega YAC clone 923f5.

    Science.gov (United States)

    Masuda, Takahisa; Moriya, Masayuki; Kataoka, Kensuke; Nishikawa, Yoshihisa

    2012-01-01

    Mouse G258 mutant stopped both cell growth and the synthesis of lipid-linked oligosaccharide at the Man(3)GlcNAc(2)-P-P-Dolichol at a restricted temperature with a single gene mutation. To clarify the lesion in the G258 mutant, we isolated human genomic DNA transformants of the G258 mutant, which recovered from both defects by way of cell hybridization with X-ray irradiated HeLa cells. We detected a common 1.3-kb product by inter-human specific sequence in the L1 (L1Hs) PCR in the transformants (Kataoka et al., Somat. Cell Mol. Genet., 24, 235-243 (1998)). In the present study, we screened a human mega yeast artificial chromosome (YAC) library by PCR with primers designed according to the 1.3-kb DNA, and selected YAC clone 923f5. Moreover, we found by spheroplast fusion that YAC clone 923f5 complemented both defects of the G258 mutant. Since the human counterpart of the yeast ALG11 gene is localized in the region, the G258 mutant might have a defect in the mouse ALG11 gene.

  18. Vapor-liquid equilibria of the (hexafluoroethane + 1,1,1-trifluoroethane) binary system from 258 to 343 K up to 3.89 MPa

    Energy Technology Data Exchange (ETDEWEB)

    Madani, Hakim; Meniai, Abdeslam Hassen [Laboratoire de l' Ingenierie des Procedes d' Environnement, Universite Mentouri Constantine (Algeria); Valtz, Alain; Coquelet, Christophe; Richon, Dominique [MINES, ParisTech, CEP/TEP - Centre Energetique et Procedes, 35 rue Saint Honore, 77305 Fontainebleau (France)

    2009-09-15

    Development of modern refrigeration systems is critical for the success of new global environmental protection efforts. The binary system of refrigerants: Hexafluoroethane (R116) + 1,1,1-trifluoroethane (R143a), has been studied with the aim of providing PTxy data. Isothermal vapor-liquid equilibrium data have been generated using the ''static-analytic'' method from 258 to 328 K at pressures from 0.39 to 3.89 MPa. The model composed of the Peng-Robinson equation of state, the Mathias-Copeman alpha function, the Wong-Sandler mixing rules and the NRTL cell theory is applied herein to correlate the data and calculate the critical line. (author)

  19. (Vapor + liquid) equilibrium data for (carbon dioxide + 1,1-difluoroethane) system at temperatures from (258 to 343) K and pressures up to about 8 MPa

    Energy Technology Data Exchange (ETDEWEB)

    Madani, Hakim [Laboratoire de l' Ingenierie des Procedes d' Environnement, Universite Mentouri Constantine (Algeria); Valtz, Alain; Coquelet, Christophe [Centre Energetique et Procedes (CEP-TEP), Mines Paris-ParisTech, CNRS FRE 2861, 35 Rue Saint Honore, 77305 Fontainebleau (France); Meniai, Abdeslam Hassen [Laboratoire de l' Ingenierie des Procedes d' Environnement, Universite Mentouri Constantine (Algeria); Richon, Dominique [Centre Energetique et Procedes (CEP-TEP), Mines Paris-ParisTech, CNRS FRE 2861, 35 Rue Saint Honore, 77305 Fontainebleau (France)], E-mail: richon@ensmp.fr

    2008-10-15

    Accurate thermo-physical data are of utmost interest for the development of new efficient refrigeration systems. Carbon dioxide (R744) and 1,1-difluoroethane (R152a) are addressed here. Isothermal (vapor + liquid) equilibrium data are reported herein for (R744 + R152a) binary system in the (258-343) K temperature range and in the (0.14 to 7.65) MPa pressure range. A reliable 'static-analytic' method taking advantage of two online ROLSI{sup TM} micro capillary samplers is used for all thermodynamic measurements. The data are correlated using our in-house ThermoSoft thermodynamic model using the Peng-Robinson equation of state, the Mathias-Copeman alpha function, the Wong-Sandler mixing rules, and the NRTL model.

  20. Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization

    DEFF Research Database (Denmark)

    Jayanthi, Lankupalle D; Annamalai, Balasubramaniam; Samuvel, Devadoss J

    2006-01-01

    ester (beta-PMA)-induced phosphorylation of NET occurs on serine and threonine residues. Beta-PMA treatment inhibited NE transport, reduced plasma membrane hNET levels, and stimulated hNET phosphorylation in human placental trophoblast cells expressing the WT-hNET. Substance P-mediated activation...... of the G alpha(q)-coupled human neurokinin 1 (hNK-1) receptor coexpressed with the WT-hNET produced effects similar to beta-PMA via PKC stimulation. In striking contrast, an hNET double mutant harboring T258A and S259A failed to show NE uptake inhibition and plasma membrane redistribution by beta-PMA or SP....... Most interestingly, the plasma membrane insertion of the WT-hNET and hNET double mutant were not affected by beta-PMA. Although the WT-hNET showed increased endocytosis and redistribution from caveolin-rich plasma membrane domains following beta-PMA treatment, the hNET double mutant was completely...

  1. Comparison of 1998 WHO/ISUP and 1973 WHO classifications for interobserver variability in grading of papillary urothelial neoplasms of the bladder. Pathological evaluation of 258 cases.

    Science.gov (United States)

    Gonul, Ipek Işik; Poyraz, Aylar; Unsal, Ciğdem; Acar, Cenk; Alkibay, Turgut

    2007-01-01

    Our aim was to compare the interobserver variability between the 1998 WHO/ISUP and 1973 WHO classifications. 258 consecutive papillary urothelial carcinomas were reviewed by two pathologists and assigned a tumor grade according to the 1973 WHO and 1998 WHO/ISUP without the knowledge of primary diagnosis and clinical follow-up. All cases were also histologically staged by the two pathologists separately as follows: pTa (noninvasive), pT1 (lamina propria invasion only), pT2 (muscularis propria invasion). Findings of both pathologists and degree of agreement were compared statistically by using Pearson's chi(2) test and kappa statistics respectively. A kappa value of 0.21-0.40 is accepted as fair, 0.41-0.60 moderate and 0.61-0.80 substantial agreement. Regardless of the pathologist, tumor grades of two classifications correlated to each other and the pathological stage (p ISUP (kappa 0.59) than the 1973 WHO (kappa 0.41), but both were still moderate. Papillary urothelial neoplasia with low malignant potential was the group of 1998 WHO/ISUP that showed the lowest degree of agreement and if excluded, interobserver variability of the 1998 WHO/ISUP decreased significantly (kappa 0.84). The diagnosis of papillary urothelial neoplasia with low malignant potential and the criteria that differentiates it from low-grade carcinomas needs improvement in order to compare the different studies and therapies and to provide more accurate information for management.

  2. Phase Equilibria of a Na+,K+//Cl-,SO42-,NO3-—H2O Quinary System at 258.15 K%258.15K下五元体系Na+,K+//Cl-,SO42-,NO3-—H2O相平衡研究

    Institute of Scientific and Technical Information of China (English)

    廖玲; 黄雪莉; 宋欢

    2016-01-01

    采用等温溶解平衡法研究了258.15 K下五元体系Na+,K+//Cl-,SO42-,NO3--H2O及其子体系Na+,K+//Cl-,NO3--H2O的相平衡关系.测定了两个体系各盐的溶解度及溶液密度(冰相区除外),并绘制相图.研究结果表明:在258.15 K,氯化钠饱和时,该五元体系平衡干盐相图由四个两盐结晶区、五条单变量溶解度曲线和两个零变量点构成, 四个两盐结晶区分别对应于 NaCl·2H2O+NaNO3, NaCl·2H2O+KNO3, NaCl·2H2O+KCl,NaCl·2H2O+Na2SO4·10H2O;与该体系298.15 K下的相图相比,K3Na(SO4)2和NaNO3·Na2SO4·H2O结晶区消失,Na2SO4·10H2O结晶区扩大,相图大为简化;在258.15 K时,上述四元体系的平衡干盐相图由四个单盐结晶区(除冰区外)、五条单变量溶解度曲线和两个零变量点构成,四个单盐结晶区分别对应于NaNO3、NaCl·2H2O、KNO3和KCl;与该体系在298.15 K下的相图相比,硝酸钾结晶区扩大很多.

  3. Positive Analysis of Peasant Households' Grain Selling Behavior and Its Influencing Factors: Based on the Analysis of a Survey of 258 Peasant Households in Jilin Province%农户售粮行为及其影响因素的实证分析——基于对吉林省258个农户的调查

    Institute of Scientific and Technical Information of China (English)

    杨子刚; 郭庆海

    2011-01-01

    依据吉林省榆树、农安等21个市县农户的258份调查数据,对农户售粮对象-粮食经纪人和粮食加工企业进行意愿影响因素的对比分析.结果表明:农户粮食销售给粮食经纪人,存储设施、运送粮食方式、与粮库距离等变量回归系数与Logistic的线性显著性明显;农户粮食销售给粮食加工企业,粮食产量、运送粮食方式、对粮价的满意程度3个变量回归系数与Logistic的线性显著性明显.其中,运送粮食方式对农户将粮食销售给粮食经纪人和粮食加工企业影响都显著.%This article is based on 258 survey data obtained from 21 cities and counties including Yushu,Nong' an, etc. in Jilin province. It analyzes the factors influencing peasant households' choices between grain brokers and food processing enterprises when they want to sell grain. The results show that peasant households' grain selling to brokers depends on the factors of facilities of storage, means of grain delivery and distance from grain depots whose regression coefficients are significantly obvious in the model of Logit. Peasant households' grain selling to food processing enterprises also depends on the factors of grain production, means of grain delivery and satisfaction of the price whose regression coefficients are significantly obvious in the model of Logit. Means of grain delivery obviously influences both food brokers and food processing enterprises.

  4. Role of routine imaging in detecting recurrent lymphoma: A review of 258 patients with relapsed aggressive non-Hodgkin and Hodgkin lymphoma.

    Science.gov (United States)

    El-Galaly, T C; Mylam, Karen Juul; Bøgsted, Martin; Brown, Peter; Rossing, Maria; Gang, Anne Ortved; Haglund, Anne; Arboe, Bente; Clausen, Michael Roost; Jensen, Paw; Pedersen, Michael; Bukh, Anne; Jensen, Bo Amdi; Poulsen, Christian Bjørn; d'Amore, Francesco; Hutchings, Martin

    2014-06-01

    After first-line therapy, patients with Hodgkin lymphoma (HL) and aggressive non-HL are followed up closely for early signs of relapse. The current follow-up practice with frequent use of surveillance imaging is highly controversial and warrants a critical evaluation. Therefore, a retrospective multicenter study of relapsed HL and aggressive non-HL (nodal T-cell and diffuse large B-cell lymphomas) was conducted. All included patients had been diagnosed during the period 2002-2011 and relapsed after achieving complete remission on first-line therapy. Characteristics and outcome of imaging-detected relapses were compared with other relapses. A total of 258 patients with recurrent lymphoma were included in the study. Relapse investigations were initiated outside preplanned visits in 52% of the patients. Relapse detection could be attributed to patient-reported symptoms alone or in combination with abnormal blood tests or physical examination in 64% of the patients. Routine imaging prompted relapse investigations in 27% of the patients. The estimated number of routine scans per relapse was 91-255 depending on the lymphoma subtype. Patients with imaging-detected relapse had lower disease burden (P = 0.045) and reduced risk of death following relapse (hazard ratio = 0.62, P = 0.02 in multivariate analysis). Patient-reported symptoms are still the most common factor for detecting lymphoma relapse and the high number of scans per relapse calls for improved criteria for use of surveillance imaging. However, imaging-detected relapse was associated with lower disease burden and a possible survival advantage. The future role of routine surveillance imaging should be defined in a randomized trial.

  5. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2016. Scientific opinion on the safety of fermented soybean extract NSK-SD® as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the fermented soybean extract NSK-SD® as a novel food (NF) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the ......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the fermented soybean extract NSK-SD® as a novel food (NF) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament...... pregnant and lactating women. The Panel noted that nattokinase exhibits in vitro fibrinolytic activity and in vivo thrombolytic activity in animals when administered parenterally. However, the information provided with respect to absorption, distribution, metabolism and excretion of the NF does not allow...

  6. Doripenem MICs and ompK36 Porin Genotypes of Sequence Type 258, KPC-Producing Klebsiella pneumoniae May Predict Responses to Carbapenem-Colistin Combination Therapy among Patients with Bacteremia

    Science.gov (United States)

    Shields, Ryan K.; Potoski, Brian A.; Press, Ellen G.; Chen, Liang; Kreiswirth, Barry N.; Clarke, Lloyd G.; Eschenauer, Gregory A.; Clancy, Cornelius J.

    2014-01-01

    Treatment failures of a carbapenem-colistin regimen among patients with bacteremia due to sequence type 258 (ST258), KPC-2-producing Klebsiella pneumoniae were significantly more likely if both agents were inactive in vitro, as defined by a colistin MIC of >2 μg/ml and the presence of either a major ompK36 porin mutation (guanine and alanine insertions at amino acids 134 and 135 [ins aa 134–135 GD], IS5 promoter insertion [P = 0.007]) or a doripenem MIC of >8 μg/ml (P = 0.01). Major ompK36 mutations among KPC-K. pneumoniae strains are important determinants of carbapenem-colistin responses in vitro and in vivo. PMID:25534733

  7. Final report on COOMET.M.M-K5: Key comparison in the field of multiples and submultiples of the kilogram (COOMET 258/RU/02)

    Science.gov (United States)

    Snegov, V. S.

    2014-01-01

    This report summarizes the results of a comparison of mass standards conducted between four participating members of the Euro-Asian Cooperation of National metrological Institutes (COOMET). The COOMET key comparisons are usually carried out on those schemes that were proposed and implemented by the Consultative Committee for Mass and Related Quantities of the CIPM. Measurement comparisons bring to the laboratories confidence in the measurement standards and lead to their international acceptance. This comparison arose from discussions at the 9th meeting of TC 1.6 'Mass and Related Quantities' on 21-23 April 2004, SMU, Slovakia. The comparison is internally identified as COOMET 258/RU/02 and corresponds to the KCDB identifier COOMET.M.M-K5, as attributed by the BIPM. The purpose of the key comparison COOMET.M.M-K5 'Comparison in the field of multiples and submultiples of the kilogram' is to compare the results of measurements obtained by the participants. Two weights sets with five nominal mass values 2 kg, 200 g, 50 g, 1 g and 200 mg (OIML Class E1) were used as transfer standards. These nominal values were chosen to follow the second phase of the CCM key comparison CCM.M-K5. The All-Russian D I Mendeleyev Research Institute for Metrology, VNIIM, was the pilot laboratory as well as the linking laboratory to CCM.M-K5. The comparison was carried out from May 2015 to July 2008. In 2007, measurements were carried out by Kazakhstan Institute of Metrology (RSE 'KazInMetr') on their own initiative. The computation of the degrees of equivalence shows a generally good agreement between participants. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  8. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on the Safety of lacto-N-neotetraose as a novel food ingredient pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on lacto-N-neotetraose as a novel food ingredient (NFI) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the Council......, taking into account the comments and objections of a scientific nature raised by Member States. Lacto-N-neotetraose (LNnT) is a synthetic tetrasaccharide, which is intended to be used in infant and follow-on formulae, foods for special medical purposes for infants and young children and other foods...

  9. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on the safety of 2'-O-fucosyllactose as a novel food ingredient pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Tetens, Inge

    2015-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on 2'-O-fucosyllactose as a novel food ingredient (NFI) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the Council......, taking into account the comments and objections of a scientific nature raised by Member States. 2'-O-fucosyllactose (2'-FL) is a synthetic trisaccharide, which is intended to be used in infant and follow-on formulae, foods for special medical purposes for infants and young children, and other foods...

  10. Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin.

    Science.gov (United States)

    Clancy, Cornelius J; Chen, Liang; Hong, Jae H; Cheng, Shaoji; Hao, Binghua; Shields, Ryan K; Farrell, Annie N; Doi, Yohei; Zhao, Yanan; Perlin, David S; Kreiswirth, Barry N; Nguyen, M Hong

    2013-11-01

    Doripenem-colistin exerts synergy against some, but not all, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if doripenem MICs and/or ompK36 porin gene mutations impacted the responses of 23 sequence type 258 (ST258), KPC-2-producing strains to the combination of doripenem (8 μg/ml) and colistin (2 μg/ml) during time-kill assays. The median doripenem and colistin MICs were 32 and 4 μg/ml. Doripenem MICs did not correlate with KPC-2 expression levels. Five and 18 strains had wild-type and mutant ompK36, respectively. The most common mutations were IS5 promoter insertions (n = 7) and insertions encoding glycine and aspartic acid at amino acid (aa) positions 134 and 135 (ins aa134-135 GD; n = 8), which were associated with higher doripenem MICs than other mutations or wild-type ompK36 (all P values ≤ 0.04). Bactericidal activity (24 h) was achieved by doripenem-colistin against 12%, 43%, and 75% of ins aa134-135 GD, IS5, and wild-type/other mutants, respectively (P = 0.04). Doripenem-colistin was more active in time-kill studies than colistin at 12 and 24 h if the doripenem MIC was ≤8 μg/ml (P = 0.0007 and 0.09, respectively), but not if the MIC was >8 μg/ml (P = 0.10 and 0.16). Likewise, doripenem-colistin was more active at 12 and 24 h against the wild type/other mutants than ins aa134-135 GD or IS5 mutants (P = 0.007 and 0.0007). By multivariate analysis, the absence of ins aa134-135 GD or IS5 mutations was the only independent predictor of doripenem-colistin responses at 24 h (P = 0.002). In conclusion, ompK36 genotypes identified ST258 KPC-K. pneumoniae strains that were most likely to respond to doripenem-colistin.

  11. 腹腔镜辅助阴式子宫切除术与阴式子宫切除术258例临床分析%A comparison study on laparoscopic assisted vaginal hysterectomy and total vaginal hysterectomy——clinical analysis of 258 cases

    Institute of Scientific and Technical Information of China (English)

    张泽莉; 王艳; 廖玲; 张士玲; 王倩

    2013-01-01

    Objective To investigate the clinical effects of laparoscopic assisted vaginal hysterectomy ( LAVH) and total vaginal hysterec-tomy(TVH)on patients with non-prolapsed uterus. Methods The clinical data of 258 patients undergoing total hysterectomy( 156 cases in LAVH group, 102 cases in TVH group) from October 2007 to August 2010 were analyzed retrospectively. Analysis was made of surgical indications ,operational time,postoperative anal exhaust time,incidence of complication,the bleeding and postoperative hospital stays. Results The operations in both groups were all successful. Operation time of LAVH group was slightly longer than that of TVH group (90.2 ±15. 6) vs (77. 5 ± 17.3)min,P0. 05) . Conclusion Both TVH and LAVH are safe and minimally invasive surgery. Compared with TVH, LAVH has obvious advantages for the patients with the uterus with more than 12 weeks or uterine fibroids merger accessories benign tumor,pelvic adhesion,which has prospects of wide application and development.%目的 探讨非脱垂子宫腹腔镜辅助阴式子宫切除术(LAVH)与阴式子宫切除术(TVH)的临床效果.方法 回顾性分析2007年10月-2010年8月行LAVH 156例、TVH 102例患者的临床资料.比较两组手术适应证、手术时间、出血量、术后住院时间.结果 LAVH组手术时间略长于TVH组[(90.2±15.6)vs(77.5±17.3)]min,P<0.05)、并发症发生率显著低于TVH组(0.007% vs 0.089%,P<0.05);LAVH组与TVH组术中出血量[(88.4±11.2)vs(93.1±13.7)]ml、术后肛门排气时间(12.8±1.9)vs(13.7±1.2)h、住院时间(5.7±0.4)vs(5.6±0.6)d比较,差异无显著意义(P>0.05).结论 LAVH较TVH术式具有更高的安全性,切除子宫大于孕12周或子宫肌瘤合并附件良性肿瘤、盆腔重度粘连的患者处理上明显优于TVH,具有广阔的应用及发展情景.

  12. The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression

    Science.gov (United States)

    Sakiyama, Masayuki; Matsuo, Hirotaka; Shimizu, Seiko; Nakashima, Hiroshi; Nakamura, Takahiro; Nakayama, Akiyoshi; Higashino, Toshihide; Naito, Mariko; Suma, Shino; Hishida, Asahi; Satoh, Takahiro; Sakurai, Yutaka; Takada, Tappei; Ichida, Kimiyoshi; Ooyama, Hiroshi; Shimizu, Toru; Shinomiya, Nariyoshi

    2016-01-01

    Urate transporter 1 (URAT1/SLC22A12), a urate transporter gene, is a causative gene for renal hypouricemia type 1. Among several reported nonsynonymous URAT1 variants, R90H (rs121907896) and W258X (rs121907892) are frequent causative mutations for renal hypouricemia. However, no case-control study has evaluated the relationship between gout and these two variants. Additionally, the effect size of these two variants on serum uric acid (SUA) levels remains to be clarified. Here, 1,993 primary gout patients and 4,902 health examination participants (3,305 males and 1,597 females) were genotyped with R90H and W258X. These URAT1 variants were not observed in any gout cases, while 174 subjects had the URAT1 variant in 2,499 health examination participants, respectively (P = 8.3 × 10−46). Moreover, in 4,902 health examination participants, the URAT1 nonfunctional variants significantly reduce the risk of hyperuricemia (P = 6.7 × 10−19; risk ratio = 0.036 in males). Males, having 1 or 2 nonfunctional variants of URAT1, show a marked decrease of 2.19 or 5.42 mg/dl SUA, respectively. Similarly, females, having 1 or 2 nonfunctional variants, also evidence a decrease of 1.08 or 3.89 mg/dl SUA, respectively. We show that URAT1 nonfunctional variants are protective genetic factors for gout/hyperuricemia, and also demonstrated the sex-dependent effect size of these URAT1 variants on SUA (P for interaction = 1.5 × 10−12). PMID:26821810

  13. Children and Youth Camp Safety Act, 1978. Hearing Before the Subcommittee on Child and Human Development of the Committee on Human Resources, United States Senate, 95th Congress, 2nd Session on S. 258--To Provide for the Development and Implementation of Programs for Children and Youth Camp Safety (March 21, 1978).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. Senate Committee on Human Resources.

    The product of some 10 years of work directed toward federal legislation addressing and defining youth camp safety, the Youth Camp Safety Act (S. 258), as presented in these hearings, calls for the federal government to assume a role in the development of state health and safety standards for children attending youth camps in any state in the…

  14. Galaxy counterparts of metal-rich damped Lyman-alpha absorbers - II. A solar-metallicity, molecular-rich, and dusty DLA at z_abs=2.58

    CERN Document Server

    Fynbo, J P U; Noterdaeme, P; Christensen, L; Moller, P; Durgapal, A K; Goldoni, P; Kaper, L; Krogager, J -K; Laursen, P; Maund, J R; Milvang-Jensen, B; Okoshi, K; Rasmussen, P K; Thorsen, T J; Toft, S; Zafar, T

    2010-01-01

    [Abridged]. Here, we report on the discovery of the galaxy counterpart of the z_abs=2.58 DLA on the line-of-sight to the z=3.07 quasar SDSS J091826.16+163609.0. The galaxy counterpart of the DLA is detected in the OIII 5007 and OII 3726,3729 emission lines redshifted into the NIR at an impact parameter of 16 kpc. Ly-alpha emission is not detected. The upper limit implies that Ly-alpha emission from this galaxy is suppressed by more than an order of magnitude. The DLA is amongst the most metal-rich DLAs studied so far at comparable redshifts. We find evidence for substantial depletion of refractory elements onto dust grains. Fitting the main metal line component of the DLA, which is located at z_abs=2.5832 and accounts for at least 85% of the total column density of low-ionisation species, we measure metal abundances from ZnII, SII, SiII, CrII, MnII, FeII and NiII of -0.12, -0.26, -0.46, -0.88, -0.92, -1.03 and -0.78, respectively. In addition, we detect absorption in the Lyman and Werner bands of hydrogen, wh...

  15. Reference: 258 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available l loss-of-function pex12 mutants using RNA interference. We show that pex12 null mutants are developmentally... rescued by overexpression of the PEX12-cyan fluorescent protein fusion protein, which targets to the peroxisome. Using virus-induce...d gene-silencing techniques, we demonstrate that peroxisomal number and fluorescence of the yellow fluoresce...nt protein-peroxisome targeting signal type 1 protein are greatly reduced when PEX12 is silence...d. RNA interference plants with partial reduction of the PEX12 transcr

  16. 40 CFR 258.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... consistent with past operating practices or modified practices to ensure good management. Facility means all...; plastics and resins manufacturing; pulp and paper industry; rubber and miscellaneous plastic products; stone, glass, clay, and concrete products; textile manufacturing; transportation equipment; and water...

  17. 37 CFR 258.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., retail stores, banks and financial institutions, supermarkets, auto and boat dealerships, and other..., the retransmission does not include any program which, if delivered by any cable system in the United...

  18. 28 CFR 25.8 - System safeguards.

    Science.gov (United States)

    2010-07-01

    ... under the authority and supervision of a state Control Terminal Agency. This authority and supervision...-criminal justice maintenance or technical personnel. (3) All visitors to these computer centers must be accompanied by staff personnel at all times. (4) POCs utilizing a state/NCIC terminal to access the NICS must...

  19. 40 CFR 258.74 - Allowable mechanisms.

    Science.gov (United States)

    2010-07-01

    ... closure and post-closure care, the first payment into the fund must be at least equal to the current cost... trust fund must be at least equal to one-half of the current cost estimate for corrective action, except... irrevocable and issued for a period of at least one year in an amount at least equal to the current...

  20. 21 CFR 558.258 - Fenbendazole.

    Science.gov (United States)

    2010-04-01

    ...)(2)(i) of this section; for reduction in the severity of swine mycoplasmal pneumonia caused by... bighorn sheep (Ovis c. canadensis) 10 mg/kg/day for 3 days. For the removal and control of Protostrongylus...

  1. KPC-3-Producing Klebsiella pneumoniae in Portugal Linked to Previously Circulating Non-CG258 Lineages and Uncommon Genetic Platforms (Tn4401d-IncFIA and Tn4401d-IncN).

    Science.gov (United States)

    Rodrigues, Carla; Bavlovič, Jan; Machado, Elisabete; Amorim, José; Peixe, Luísa; Novais, Ângela

    2016-01-01

    recent penetration of successful mobile genetic elements in previously circulating MDR K. pneumoniae lineages (mainly ST147 and ST15) in Portugal, rather than the importation of the global lineages from clonal group 258.

  2. Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylation of Thr258 of murine MITOGEN-ACTIVATED protein kinase kinase 4.

    Science.gov (United States)

    Vacratsis, P O; Gallo, K A

    2000-09-08

    Src homology 3 domain-containing proline-rich kinase (SPRK)/mixed lineage kinase-3 is a serine/threonine kinase that has been identified as an upstream activator of the c-Jun NH(2)-terminal kinase (JNK) pathway. SPRK is capable of activating MKK4 by phosphorylation of serine and threonine residues, and mutant forms of MKK4 that lack the phosphorylation sites Ser(254) and Thr(258) block SPRK-induced JNK activation. A region of 63 amino acids following the kinase domain of SPRK is predicted to form a leucine zipper. The leucine zipper domain of SPRK has been shown to be necessary and sufficient for SPRK oligomerization, but its role in regulating activation of SPRK and downstream signaling remains unclear. In this study, we substituted a proposed stabilizing leucine residue in the zipper domain with a helix-disrupting proline to abrogate zipper-mediated SPRK oligomerization. We demonstrate that constitutively activated Cdc42 fully activates this monomeric SPRK mutant in terms of both autophosphorylation and histone phosphorylation activity and induces the same in vivo phosphorylation pattern as wild type SPRK. However, this catalytically active SPRK zipper mutant is unable to activate JNK. Our data show that the monomeric SPRK mutant fails to phosphorylate one of the two activating phosphorylation sites, Thr(258), of MKK4. These studies suggest that zipper-mediated SPRK oligomerization is not required for SPRK activation by Cdc42 but instead is critical for proper interaction and phosphorylation of a downstream target, MKK4.

  3. Incorporation of N0 stage with insufficient numbers of lymph nodes into N1 stage in the seventh edition of the TNM classification improves prediction of prognosis in gastric cancer-results of a single-institution study of 1 258 Chinese patients

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Objective:This study examined the prognosis of the “node-negative with eLNs≤15” designation and the additional value of incorporating it into the pN1 designation in the seventh edition N classification.Methods: From Jan 2000 to Sep 2010, a total of 1,258 gastric cancer patients undergoing radical gastric resection were enrolled. We incorporated node-negative patients with eLNs≤15 into pN1 and compared this designation with the 7th edition UICC N stage for 3.5- year overall survival by univariate and multivariate analysis. Homogeneity, discriminatory ability, and monotonicity of gradients in hypothetical N stage and UICC N stage were compared using linear trendχ2, likelihood ratioχ2 statistics, and Akaike information criterion (AIC) calculations.Results:Node-negative patients with eLNs≤15 had worse survival compared with those with eLNs >15. The hypothetical N stage had higher linear trend and likelihood ratioχ2 scores and smaller AIC values compared with those for the 7th edition N stage, which represented the optimum prognostic stratification.Conclusion:Node-negative patients with eLNs≤15 can be considered to be incorporated into the pN1 stage in the 7th edition of th e TNM classiifcation.

  4. Dicty_cDB: AFH258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6. 2 Translated Amino Acid sequence gllxskinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkilmilk...vrqfqs*wvlinckl*iqsmvgfhqrcnkqimilkscllvf ywvplmhl*fgkvqerpq*fvdslkihfgvnkiisssirhqaqvmnisplsil*nlvipm vqyws...*nkkkl* Frame B: gllxskinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkilmilkq* hhh*SQNPLVAVLVKINHHHHHHVVVVVIK

  5. Dicty_cDB: VHK258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s Protein Score E Sequences producing significant alignments: (bits) Value L25926_1( L25926 |pid:none) Rat sucrase-isomalt...ase (SI) mRNA, comp... 39 0.057 ( P23739 ) RecName: Full=Sucrase-isomaltase, intestinal; Conta...ins:... 39 0.057 ( O62653 ) RecName: Full=Sucrase-isomaltase, intestinal; Contain...none) Mus musculus sucrase-isomaltase mR... 38 0.13 AB045751_1( AB045751 |pid:none) Schizosaccharomyces pomb... |pid:none) Homo sapiens sucrase-isomaltase (a... 37 0.28 ( P14410 ) RecName: Full=Sucrase-isomaltase, intes

  6. Dicty_cDB: SHJ258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 02.10.25 Translated Amino Acid sequence vkccstinptfmink*KRREKKMNVKEMDFNDLSNKSNQIINRISSFSSPIGLSSFNIER NLQEIGD...LEEILG QKHIKVLPSV--- Translated Amino Acid sequence (All Frames) Frame A: vkccstinptfmink

  7. Dicty_cDB: SFA258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available m chromosome 2 map 1685067-2090751 strain AX4, complete sequence. 494 0.0 10 AF493055 |AF493055.1 Neocallimas... 74 8e-19 2 X84222 |X84222.2 Neocallimastix frontalis mRNA for beta-succinyl CoA synthetase precursor. 74 3e

  8. Worldwide Report, Telecommunications Policy, Research and Development, No. 258

    Science.gov (United States)

    2007-11-02

    35 NIGER Television To Be Operational Soon in Gaya (LE SAHEL , 15 Nov 82) 37 NIGERIA ABC Back on Air Following Disruption by ’Saboteurs...endangered; drilling, stacking of heavy and bulky articles, garbage or slag or pouring of liquids of acid, alkaline or saline content on the ground where an...GAYA Niamey LE SAHEL in French 15 Nov 82 pp 2,3 [Article: "The Director General of ORTN [Niger Radio and Television Broadcasting Office] to Our

  9. Dicty_cDB: SHL258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 9.1 Rasgsc1686 Salivary Gland 4th instar 3rd period (spinning cocoon) Rhynchosciara americana cDNA, mRNA seq...uence. 34 4e-05 3 CK808739 |CK808739.1 Rasgsc1529 Salivary Gland 4th instar 3rd period (spinning cocoon) Rhy...808037 |CK808037.1 Rasgsc0316 Salivary Gland 4th instar 3rd period (spinning cocoon) Rhynchosciara americana

  10. Dicty_cDB: CFG258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lsmms rtfwqi*sswlklvkpmnnssdfskmpsyslaispmimslrsswktgrpplsrwqrvqrd vvsfvpppkl*lilkvvnlysdsfqrqvnsfk**fwiktln...B: vm*skhq**dqmvfqlqllhqmspi*sylnvitivwke*wklvslerkpmtkpkrlsmms rtfwqi*sswlklvkpmnnssdfskmpsyslaispmimslrssw

  11. 42 CFR 403.258 - Statement of actuarial opinion.

    Science.gov (United States)

    2010-10-01

    ... actuarial opinion means a signed declaration in which a qualified actuary states that the assumptions used... policy experience, if any, and reasonable expectations. (b) Qualified actuary means— (1) A member in good standing of the American Academy of Actuaries; or (2) A person who has otherwise demonstrated his or...

  12. 17 CFR 230.258 - Suspension of the exemption.

    Science.gov (United States)

    2010-04-01

    ... fact necessary in order to make the statements made, in light of the circumstances under which they are... specified in paragraph (a) of § 230.262 has been indicted for any crime or offense of the character... any crime or offense of the character specified in paragraph (b)(1) of § 230.262, or any...

  13. 40 CFR 258.41 - Project XL Bioreactor Landfill Projects.

    Science.gov (United States)

    2010-07-01

    ... geosynthetic clay liner (GCL) overlaying and in direct contact with the 18 inches of compacted soil in... direct and uniform contact with an overlaying soil cushioning component. (v) Underlying the above liner... recirculation is allowed only to the extent that the integrity of the landfill including its liner system...

  14. Dicty_cDB: VFD258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available wrfiwsnytssynnnxixxyxiix xrrrfiwwiyxytiin*wwiiwsnyxssynnyixxytiin*wwiiwxnxxinyxriiwsx xnnxnntinyiyxxsixnyrri...rwiiwww*fnntsnrrwwfi wrclnntsnrrrfiwrclnntsnrwwfiwrclnntsnrwwwfiwr**hystsnrwwwfiw wfynnctsnywriiwr**hystinnnwwii...rrffnnytinnnnrriiwrcfnnctinnnr wiiwsnytsnysnnnnrwiiwriynhtiinkwwrfiwsnytssynnnnilsytiin*rrr xiwwiynytxin*wwii

  15. 40 CFR 258.57 - Selection of remedy.

    Science.gov (United States)

    2010-07-01

    ... surrounding land; (vi) Ground-water removal and treatment costs; and (vii) The cost and availability of alternative water supplies. (7) Practicable capability of the owner or operator. (8) Other relevant factors...) Is not currently or reasonably expected to be a source of drinking water; and (ii) Is not...

  16. Dicty_cDB: CHD258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |BG790353.1 sae68c10.y1 Gm-c1064 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1064-3212 5' similar t...797 |BE800797.1 sq98c12.y1 Gm-c1049 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1049-1199 5' similar...1 Gm-c1007 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1007-2626 5' simil...SOCIATION INHIBITOR. ;, mRNA sequence. 62 4e-08 2 BI315670 |BI315670.1 saf75f12.y1 Gm-c1078 Glycine max cDNA clone GENOME SYSTEMS...DISSOCIATION INHIBITOR. ;, mRNA sequence. 62 1e-07 2 AI437629 |AI437629.1 sa37e09.y1 Gm-c1004 Glycine max cDNA clone GENOME SYSTEMS

  17. 29 CFR 779.258 - Sales made or business done.

    Science.gov (United States)

    2010-07-01

    ... would include, for example, such activity by an enterprise as making loans or renting or leasing... RETAILERS OF GOODS OR SERVICES Employment to Which the Act May Apply; Enterprise Coverage Annual Gross... “the gross receipts or gross business” to determine whether an enterprise is covered. This concept...

  18. 4 CFR 25.8 - Alcoholic beverages and narcotics.

    Science.gov (United States)

    2010-01-01

    ... alcoholic beverages, narcotic drugs, hallucinogens, marijuana, barbiturates, or amphetamines is prohibited..., marijuana, barbiturate, or amphetamine. This prohibition shall not apply in cases where the drug is...

  19. Dicty_cDB: SSD258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AB209776_1( AB209776 |pid:none) Homo sapiens mRNA for prosaposin v... 83 7e-15 A...K223290_1( AK223290 |pid:none) Homo sapiens mRNA for prosaposin (... 83 7e-15 CR861454_1( CR861454 |pid:none

  20. Dicty_cDB: VHD258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available restriction enzymes : HindIII (clone prefix : VCS1H) and EcoRI (clone prefix : VCS1E). 36 2.5 3 DQ241798 |D...Q241798.1 Sclerophasma paresisensis mitochondrion, complete genome. 32 2.6 2 AC199311 |AC199311.2 Dasypus no

  1. Dicty_cDB: SSC258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available IFAFCIFNLFTHIVGIGTDTIFVCYLEDLETNKDGNLYIS PDLHELLQDKCNECKEKEQKNQSKV*iflkk*divenikiiiiitifillfsffifill* lihiei...FT TALLYGMGKSLNPITIALSAIFAFCIFNLFTHIVGIGTDTIFVCYLEDLETNKDGNLYIS PDLHELLQDKCNECKEKEQKNQSKV*iflkk*divenikiiiii

  2. Chemical Identification of Dubnium as a Decay Product of Element 115 Produced in the Reaction $\\rm {^{48}Ca}+{^{243}Am}$

    CERN Document Server

    Dmitriev, S N; Utyonkov, V K; Shishkin, S V; Eremin, A V; Lobanov, Yu V; Chepigin, V I; Sokol, E A; Tsyganov, Yu S; Vostokin, G K; Aksenov, N V; Hussonnois, M; Itkis, M G; Aggeler, H W; Schumann, D; Bruchertseifer, H; Eichler, R; Shaughnessy, D A; Wilk, P A; Kenneally, J M; Stoyer, M A; Wild, J F

    2004-01-01

    The results of an experiment designed to identify $^{268}$Db as the terminal isotope in the $\\alpha $-decay chain of element 115 produced via the ${\\rm {^{243}Am}}({\\rm {^{48}Ca}},3n){\\rm {^{288}115}}$ reaction are presented. The $^{243}$Am target was bombarded with a beam dose of $3.4\\cdot 10^{18}$ $^{48}$Ca projectiles at an energy of 247 MeV at the center of the target. The reaction products were collected in the surface layer of a copper catcher block, which was removed with a lathe and then dissolved in concentrated HNO$_{3}$. The group-5 elements were separated by sorption onto Dowex $50{\\times} 8$ cation-exchange resin with subsequent desorption using 1 M HF, which forms anionic fluoride complexes of group-5 elements. The eluent was evaporated onto a 0.4 $\\mu$m thick polyethylene foil that was placed between a pair of semiconductor detectors surrounded by $^{3}$He neutron counters for measurement of $\\alpha$ particles, fission fragments, and neutrons. In the course of the experiment, we observed 15 spo...

  3. First Report of Chronic Pulmonary Infection by KPC-3-Producing and Colistin-Resistant Klebsiella pneumoniae Sequence Type 258 (ST258) in an Adult Patient with Cystic Fibrosis

    Science.gov (United States)

    Delfino, Emanuele; Del Bono, Valerio; Coppo, Erika; Marchese, Anna; Manno, Graziana; Morelli, Patrizia; Minicucci, Laura; Viscoli, Claudio

    2015-01-01

    The spread of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae continues to increase, and the possible development of KPC-producing K. pneumoniae infections in cystic fibrosis (CF) patients is a matter of concern. Here, we describe the establishment of a chronic lung infection due to a colistin-resistant KPC-producing K. pneumoniae isolate in an Italian CF patient. PMID:25653395

  4. 40 CFR Appendix I to Part 258 - Constituents for Detection Monitoring

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Constituents for Detection Monitoring... for Detection Monitoring Common name 1 CAS RN 2 Inorganic Constituents: (1) Antimony (Total) (2) Arsenic (Total) (3) Barium (Total) (4) Beryllium (Total) (5) Cadmium (Total) (6) Chromium (Total)...

  5. Zhang et al., Afr J Tradit Complement Altern Med. (2013) 10(2):258 ...

    African Journals Online (AJOL)

    AJTCAM

    are being pursued by pharmaceutical companies as rich sources for drug discovery (Hsiao and Liu, 2010). Juglans ..... can induce apoptosis are considered to have potential as anticancer. According to the ... British Jornal of Pharmacology.

  6. S. Aft. J. Anim. Sci., 4, 247-258 (1974) INTENSIFICATION OF THE ...

    African Journals Online (AJOL)

    mature cows and for thc replacement heifers was based on ..... (9) Production and costing data based on Report of Sub Enterprise Systems team. .... SYIT1INGTON, R.B. & HALE, DJl., 1967 Stimuhtion of post partum sexual activity in ranch ...

  7. 75 FR 258 - Airworthiness Directives; Bombardier, Inc. (Type Certificate Previously Held by Bombardier...

    Science.gov (United States)

    2010-01-05

    ... from the aircraft before the NLG safety pin is installed, any pressure, including residual pressure, in... safety pin is installed, any pressure, including residual pressure, in the No. 3 hydraulic system can.... Subsequently, if electrical power is transferred or removed from the aircraft before the NLG safety pin...

  8. Zhang et al., Afr J Tradit Complement Altern Med. (2013) 10(2):258 ...

    African Journals Online (AJOL)

    AJTCAM

    Cytotoxicity of the positive control vincristine sulfate was evaluated by MTT after 48h .... also the headquarters for different catabolic and anabolic processes, calcium ... studies suggest a role for mitochondria in maintaining genomic stability.

  9. Reforming the Inter-American Defense Board (Strategic Forum, Number 258, August 2010)

    Science.gov (United States)

    2010-08-01

    person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control...PAGES 6 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8...Interamericana de Defensa en la Actualidad y la Necesidad de Romper Su Paradigma,” November 2009, slide 7. 5 There is no grouping of joint staffs in the

  10. Yeast Interacting Proteins Database: YGL145W, YNL258C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ripheral membrane protein required for Golgi-to-ER retrograde traffic; component ... membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interact

  11. Yeast Interacting Proteins Database: YFR015C, YLR258W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entr...; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into statio

  12. Yeast Interacting Proteins Database: YNL258C, YKR022C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ity (BRITE) - Alternative path with 1 intervening protein (YPD) 0 Alternative path with 2 intervening proteins (YPD) 0 IST hit 3 IST hit in the opposite bait/prey orientation - ...

  13. Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production

    DEFF Research Database (Denmark)

    Soares, Siomar C; Trost, Eva; Ramos, Rommel T J;

    2013-01-01

    Corynebacterium pseudotuberculosis is the causative agent of several veterinary diseases in a broad range of economically important hosts, which can vary from caseous lymphadenitis in sheep and goats (biovar ovis) to ulcerative lymphangitis in cattle and horses (biovar equi). Existing vaccines ag...

  14. Alison Kafer, Feminist Queer Crip (Indiana: Indiana University Press, 2013, pp. 258, ISBN: 9780253009340, £16.99, paperback.

    Directory of Open Access Journals (Sweden)

    Eve Lacey

    2014-01-01

    Full Text Available In Feminist Queer Crip, Alison Kafer endeavours to re-politicise disability and its relations to gender and sexuality. This entails a thorough examination of the ways in which time can be or become 'crip' – a critical term for 'imagining bodies and desires otherwise' – with a focus on those bodies that won't grow, age, labour or reproduce according to normal standards of growth and productivity. Kafer also examines bodies that are visually reproduced, or omitted, to facilitate the production of a political agenda, and how the continual reproduction of the able-bodied norm may be challenged or undone. She writes with an acute awareness of intersectionality and her understanding of reproductive politics repeatedly challenges ableist notions of care, future, and productivity. She first identifies problems with the medical model of disability, which constructs a timeline that can only lead to cure or failure, and with the social model, which risks ignoring the lived realities of pain until 'cure becomes the future no self-respecting disability activist or scholar wants' (p. 7. Kafer then arrives at a political and relational stance, one which prioritises coalition over diagnosis and which recognises that disability 'does not occur in isolation' (p. 8. Her relational model takes into account partnerships with carers and attendants and assisting animals, and a focus on political allegiance allows room for Robert McRuer's theory of a 'non-disabled claim to crip': an expansive identity politics which extends beyond diagnostics and towards the deconstructive principle that everyone is, has or will be disabled, and so has a stake in dismantling the ablebodied ideal. The bounds of these relations move from the social to the temporal – Feminist Queer Crip suggests that disability occurs in time, or out of it, and is often marked by a rupture in the rhythm of ableist lifetimes.

  15. 用iPod放投影——优派PJ258D投影机

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    iPod是风靡全球的MP3播放器,因此,不少厂商都推出了相当多专门针对iPod的附件,即时是传统硬件也在接口上或功能上与iPod兼容,足可见iPod的魅力。优派在此前推出的VXl945wm宽屏LCD显示器就创新地支持iPod,而现在,又在投影机上专门为iPod设计了即插即用接口,用于直接播放iPod内的视频和照片。

  16. PHYS: Division of Physical Chemistry 258 - Properties and Origins of Cometary and Asteroidal Organic Matter Delivered to the Early Earth

    Science.gov (United States)

    Messenger, Scott; Nguyen, Ann

    2017-01-01

    Comets and asteroids may have contributed much of the Earth's water and organic matter. The Earth accretes approximately 4x10(exp 7) Kg of dust and meteorites from these sources every year. The least altered meteorites contain complex assemblages of organic compounds and abundant hydrated minerals. These carbonaceous chondrite meteorites probably derive from asteroids that underwent hydrothermal processing within the first few million years after their accretion. Meteorite organics show isotopic and chemical signatures of low-T ion-molecule and grain-surface chemistry and photolysis of icy grains that occurred in cold molecular clouds and the outer protoplanetary disk. These signatures have been overprinted by aqueously mediated chemistry in asteroid parent bodies, forming amino acids and other prebiotic molecules. Comets are much richer in organic matter but it is less well characterized. Comet dust collected in the stratosphere shows larger H and N isotopic anomalies than most meteorites, suggesting better preservation of primordial organics. Rosetta studies of comet 67P coma dust find complex organic matter that may be related to the macromolecular material that dominates the organic inventory of primitive meteorites. The exogenous organic material accreting on Earth throughout its history is made up of thousands of molecular species formed in diverse processes ranging from circumstellar outflows to chemistry at near absolute zero in dark cloud cores and the formative environment within minor planets. NASA and JAXA are currently flying sample return missions to primitive, potentially organic-rich asteroids. The OSIRIS-REx and Hayabusa2 missions will map their target asteroids, Bennu and Ryugu, in detail and return regolith samples to Earth. Laboratory analyses of these pristine asteroid samples will provide unprecedented views of asteroidal organic matter relatively free of terrestrial contamination within well determined geological context. Studies of extraterrestrial materials and returned samples are essential to understand the origins of Solar System organic material and the roles of comets and asteroids to providing the starting materials for the emergence of life.

  17. Opinions and decisions of the Nuclear Regulatory Commission with selected orders, July 1, 1995--December 31, 1995. Volume 42, Pages 1-258

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    This is the 42nd volume of issuances of the U.S. Nuclear Regulatory Commission (NRC) and its Atomic Safety and Licensing Boards, Administrative Law Judges, and Office Directors. This book is a reprinting, containing corrections of numerous printing errors in a previously distributed book. It covers the period from July 1, 1995 to December 31, 1995. Atomic Safety and Licensing Boards conduct adjudicatory hearings on applications to construct and operate nuclear power plants and related facilities, and issue initial decisions which, subject to internal review and appellate procedures, become the final Commission action with respect to those applications. The hardbound edition of the Nuclear Regulatory Commission Issuances is a final compilation of the monthly issuances. It includes all of the legal precedents for the agency within a 6-month period. Any opinions, decisions, denials, memoranda and orders of the Commission inadvertently omitted from the monthly editions and any corrections submitted by the NRC legal staff to the printed softbound issuances are contained in the hardbound edition.

  18. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

    Science.gov (United States)

    Justice, Anne E; Winkler, Thomas W; Feitosa, Mary F; Graff, Misa; Fisher, Virginia A; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S; Ahluwalia, Tarunveer S; Chu, Audrey Y; Heard-Costa, Nancy L; Lim, Elise; Perez, Jeremiah; Eicher, John D; Kutalik, Zoltán; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F; Bonnefond, Amelie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E; Jackson, Anne U; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P S; Müller-Nurasyid, Martina; Navarro, Pau; Pérusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A; Stančáková, Alena; Strawbridge, Rona J; Stringham, Heather M; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van der Most, Peter J; Van Vliet-Ostaptchouk, Jana V; Vedantam, Sailaja L; Verweij, Niek; Vink, Jacqueline M; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Hua Zhao, Jing; Zimmermann, Martina E; Zubair, Niha; Abecasis, Gonçalo R; Adair, Linda S; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J L; Bartz, Traci M; Beilby, John; Bergman, Richard N; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L; Bottinger, Erwin; Braga, Daniele; Buckley, Brendan M; Buyske, Steve; Campbell, Harry; Chambers, John C; Collins, Francis S; Curran, Joanne E; de Borst, Gert J; de Craen, Anton J M; de Geus, Eco J C; Dedoussis, George; Delgado, Graciela E; den Ruijter, Hester M; Eiriksdottir, Gudny; Eriksson, Anna L; Esko, Tõnu; Faul, Jessica D; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B; Grarup, Niels; Haitjema, Saskia; Hallmans, Göran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B; Hartman, Catharina A; Hassinen, Maija; Hastie, Nicholas D; Heath, Andrew C; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J; Hollensted, Mette; Holmen, Oddgeir L; Homuth, Georg; Jan Hottenga, Jouke; Huang, Jie; Hung, Joseph; Hutri-Kähönen, Nina; Ingelsson, Erik; James, Alan L; Jansson, John-Olov; Jarvelin, Marjo-Riitta; Jhun, Min A; Jørgensen, Marit E; Juonala, Markus; Kähönen, Mika; Karlsson, Magnus; Koistinen, Heikki A; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Krämer, Bernhard K; Kuusisto, Johanna; Kvaløy, Kirsti; Lakka, Timo A; Langenberg, Claudia; Launer, Lenore J; Leander, Karin; Lee, Nanette R; Lind, Lars; Lindgren, Cecilia M; Linneberg, Allan; Lobbens, Stephane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A F; Männikkö, Reija; Marques-Vidal, Pedro; Martin, Nicholas G; McKenzie, Colin A; McKnight, Barbara; Mellström, Dan; Menni, Cristina; Montgomery, Grant W; Musk, Aw Bill; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M; Oldehinkel, Albertine J; Olden, Matthias; Ong, Ken K; Padmanabhan, Sandosh; Peyser, Patricia A; Pisinger, Charlotta; Porteous, David J; Raitakari, Olli T; Rankinen, Tuomo; Rao, D C; Rasmussen-Torvik, Laura J; Rawal, Rajesh; Rice, Treva; Ridker, Paul M; Rose, Lynda M; Bien, Stephanie A; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A; Sennblad, Bengt; Siemelink, Marten A; Silbernagel, Günther; Slagboom, P Eline; Snieder, Harold; Staessen, Jan A; Stott, David J; Swertz, Morris A; Swift, Amy J; Taylor, Kent D; Tayo, Bamidele O; Thorand, Barbara; Thuillier, Dorothee; Tuomilehto, Jaakko; Uitterlinden, Andre G; Vandenput, Liesbeth; Vohl, Marie-Claude; Völzke, Henry; Vonk, Judith M; Waeber, Gérard; Waldenberger, Melanie; Westendorp, R G J; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H R; Wong, Andrew; Wright, Alan F; Zhao, Wei; Zillikens, M Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Böger, Carsten A; Boomsma, Dorret I; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I; Chen, Yii-DerIda; Chines, Peter S; Cooper, Richard S; Cucca, Francesco; Cusi, Daniele; Faire, Ulf de; Ferrucci, Luigi; Franks, Paul W; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans-Jörgen; Gudnason, Vilmundur; Haiman, Christopher A; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D; Wouter Jukema, J; Kardia, Sharon L R; Kivimaki, Mika; Kooner, Jaspal S; Kuh, Diana; Laakso, Markku; Lehtimäki, Terho; Marchand, Loic Le; März, Winfried; McCarthy, Mark I; Metspalu, Andres; Morris, Andrew P; Ohlsson, Claes; Palmer, Lyle J; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M; Qi, Lu; Rauramaa, Rainer; Smith, Blair H; Sørensen, Thorkild I A; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J; Weir, David R; Whitfield, John B; Wilson, James F; Tyrrell, Jessica; Frayling, Timothy M; Barroso, Inês; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S; Hirschhorn, Joel N; Hunter, David J; Spector, Tim D; Strachan, David P; van Duijn, Cornelia M; Heid, Iris M; Mohlke, Karen L; Marchini, Jonathan; Loos, Ruth J F; Kilpeläinen, Tuomas O; Liu, Ching-Ti; Borecki, Ingrid B; North, Kari E; Cupples, L Adrienne

    2017-04-26

    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

  19. SU-E-T-258: Development of a New Patient Set-Up Monitoring System Using Force Sensing Resistor (FSR) Sensor for the Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Cho, M; Kim, T; Kang, S; Kim, D; Kim, K; Shin, D; Suh, T [The Catholic University of Korea College of Medicine, Seoul (Korea, Republic of)

    2015-06-15

    Purpose: The purpose of this work is to develop a new patient set-up monitoring system using force sensing resistor (FSR) sensors that can confirm pressure of contact surface and evaluate its feasibility. Methods: In this study, we focused on develop the patient set-up monitoring system to compensate for the limitation of existing optical based monitoring system, so the developed system can inform motion in the radiation therapy. The set-up monitoring system was designed consisting of sensor units (FSR sensor), signal conditioning devices (USB cable/interface electronics), a control PC, and a developed analysis software. The sensor unit was made by attaching FSR sensor and dispersing pressure sponge to prevent error which is caused by concentrating specific point. Measured signal from the FSR sensor was sampled to arduino mega 2560 microcontroller, transferred to control PC by using serial communication. The measured data went through normalization process. The normalized data was displayed through the developed graphic user interface (GUI) software. The software was designed to display a single sensor unit intensity (maximum 16 sensors) and display 2D pressure distribution (using 16 sensors) according to the purpose. Results: Changes of pressure value according to motion was confirmed by the developed set-up monitoring system. Very small movement such as little physical change in appearance can be confirmed using a single unit and using 2D pressure distribution. Also, the set-up monitoring system can observe in real time. Conclusion: In this study, we developed the new set-up monitoring system using FSR sensor. Especially, we expect that the new set-up monitoring system is suitable for motion monitoring of blind area that is hard to confirm existing optical system and compensate existing optical based monitoring system. As a further study, an integrated system will be constructed through correlation of existing optical monitoring system. This work was supported by the Industrial R&D program of MOTIE/KEIT. [10048997, Development of the core technology for integrated therapy devices based on real-time MRI guided tumor tracking] and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.

  20. Scientific opinion on the safety of proline-specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    . Taking into account the intended maximum use level for Tolerase® G, its daily consumption would correspond to 2,746 mg TOS/person or to 39.2 mg TOS/kg body weight (bw) per day, when considering a default body weight of 70 kg for an adult person. The margin between this value and the dose in the rats...

  1. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

    NARCIS (Netherlands)

    Justice, A.E.; Winkler, T.W.; Feitosa, M.F.; Graff, M.; Fisher, V.A.; Young, K.; Vink, J.M.; North, K.E.; Cupples, L.A.

    2017-01-01

    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87%

  2. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

    Science.gov (United States)

    Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltán; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F.; Bonnefond, Amelie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E.; Jackson, Anne U.; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E.; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P. S.; Müller-Nurasyid, Martina; Navarro, Pau; Pérusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A.; Stančáková, Alena; Strawbridge, Rona J.; Stringham, Heather M.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W.; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Vedantam, Sailaja L.; Verweij, Niek; Vink, Jacqueline M.; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Hua Zhao, Jing; Zimmermann, Martina E.; Zubair, Niha; Abecasis, Gonçalo R.; Adair, Linda S.; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J. L.; Bartz, Traci M.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L.; Bottinger, Erwin; Braga, Daniele; Buckley, Brendan M.; Buyske, Steve; Campbell, Harry; Chambers, John C.; Collins, Francis S.; Curran, Joanne E.; de Borst, Gert J.; de Craen, Anton J. M.; de Geus, Eco J. C.; Dedoussis, George; Delgado, Graciela E.; den Ruijter, Hester M.; Eiriksdottir, Gudny; Eriksson, Anna L.; Esko, Tõnu; Faul, Jessica D.; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B.; Grarup, Niels; Haitjema, Saskia; Hallmans, Göran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B.; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas D.; Heath, Andrew C.; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J.; Hollensted, Mette; Holmen, Oddgeir L.; Homuth, Georg; Jan Hottenga, Jouke; Huang, Jie; Hung, Joseph; Hutri-Kähönen, Nina; Ingelsson, Erik; James, Alan L.; Jansson, John-Olov; Jarvelin, Marjo-Riitta; Jhun, Min A.; Jørgensen, Marit E.; Juonala, Markus; Kähönen, Mika; Karlsson, Magnus; Koistinen, Heikki A.; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Krämer, Bernhard K.; Kuusisto, Johanna; Kvaløy, Kirsti; Lakka, Timo A.; Langenberg, Claudia; Launer, Lenore J.; Leander, Karin; Lee, Nanette R.; Lind, Lars; Lindgren, Cecilia M.; Linneberg, Allan; Lobbens, Stephane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A. F.; Männikkö, Reija; Marques-Vidal, Pedro; Martin, Nicholas G.; McKenzie, Colin A.; McKnight, Barbara; Mellström, Dan; Menni, Cristina; Montgomery, Grant W.; Musk, AW (Bill); Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Oldehinkel, Albertine J.; Olden, Matthias; Ong, Ken K.; Padmanabhan, Sandosh; Peyser, Patricia A.; Pisinger, Charlotta; Porteous, David J.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rasmussen-Torvik, Laura J.; Rawal, Rajesh; Rice, Treva; Ridker, Paul M.; Rose, Lynda M.; Bien, Stephanie A.; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A.; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A.; Sennblad, Bengt; Siemelink, Marten A.; Silbernagel, Günther; Slagboom, P Eline; Snieder, Harold; Staessen, Jan A.; Stott, David J.; Swertz, Morris A.; Swift, Amy J.; Taylor, Kent D.; Tayo, Bamidele O.; Thorand, Barbara; Thuillier, Dorothee; Tuomilehto, Jaakko; Uitterlinden, Andre G.; Vandenput, Liesbeth; Vohl, Marie-Claude; Völzke, Henry; Vonk, Judith M.; Waeber, Gérard; Waldenberger, Melanie; Westendorp, R. G. J.; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H. R.; Wong, Andrew; Wright, Alan F.; Zhao, Wei; Zillikens, M Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Böger, Carsten A.; Boomsma, Dorret I.; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I.; Chen, Yii-DerIda; Chines, Peter S.; Cooper, Richard S.; Cucca, Francesco; Cusi, Daniele; Faire, Ulf de; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans- Jörgen; Gudnason, Vilmundur; Haiman, Christopher A.; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D.; Wouter Jukema, J; Kardia, Sharon L. R.; Kivimaki, Mika; Kooner, Jaspal S.; Kuh, Diana; Laakso, Markku; Lehtimäki, Terho; Marchand, Loic Le; März, Winfried; McCarthy, Mark I.; Metspalu, Andres; Morris, Andrew P.; Ohlsson, Claes; Palmer, Lyle J.; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M.; Qi, Lu; Rauramaa, Rainer; Smith, Blair H.; Sørensen, Thorkild I. A.; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J.; Weir, David R.; Whitfield, John B.; Wilson, James F.; Tyrrell, Jessica; Frayling, Timothy M.; Barroso, Inês; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S.; Hirschhorn, Joel N.; Hunter, David J.; Spector, Tim D.; Strachan, David P.; van Duijn, Cornelia M.; Heid, Iris M.; Mohlke, Karen L.; Marchini, Jonathan; Loos, Ruth J. F.; Kilpeläinen, Tuomas O.; Liu, Ching-Ti; Borecki, Ingrid B.; North, Kari E.; Cupples, L Adrienne

    2017-01-01

    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution. PMID:28443625

  3. 77 FR 6782 - In the Matter of: Kok Tong Lim, a/k/a Thomas Lim Blk 258A Compassvale Road #07-551 Singapore...

    Science.gov (United States)

    2012-02-09

    ... Road 07-551 Singapore 541258; Order Denying Export Privileges On October 9, 2009, in the U.S. District Court, District of Minnesota, Kok Tong Lim, a/k/a Thomas Lim, (``Lim'') of Singapore, pled guilty to one... China Academy of Space Technology. Lim was sentenced for a prison term of time served, which amounted...

  4. SU-E-J-258: Prediction of Cervical Cancer Treatment Response Using Radiomics Features Based On F18-FDG Uptake in PET Images

    Energy Technology Data Exchange (ETDEWEB)

    Altazi, B; Fernandez, D; Zhang, G; Biagioli, M; Moros, E; Moffitt, H. Lee [Cancer Center, Tampa, FL, University of South Florida, Tampa, FL (United States)

    2015-06-15

    Purpose: Radiomics have shown potential for predicting treatment outcomes in several body sites. This study investigated the correlation between PET Radiomics features and treatment response of cervical cancer outcomes. Methods: our dataset consisted of a cohort of 79 patients diagnosed with cervical cancer, FIGO stage IB-IVA, age range 25–86 years, (median age at diagnosis: 50 years) all treated between: 2009–14 with external beam radiation therapy to a dose range between: 45–50.4 Gy (median= 45 Gy), concurrent cisplatin chemotherapy and MRI-based brachytherapy to a dose of 20–30 Gy (median= 28 Gy). Metabolic Tumor Volume (MTV) in patient’s primary site was delineated on pretreatment PET/CT by two board certified Radiation Oncologists. The features extracted from each patient’s volume were: 26 Co-occurrence matrix (COM) Feature, 11 Run-Length Matrix (RLM), 11 Gray Level Size Zone Matrix (GLSZM) and 33 Intensity-based features (IBF). The treatment outcome was divided based on the last follow up status into three classes: No Evidence of Disease (NED), Alive with Disease (AWD) and Dead of Disease (DOD). The ability for the radiomics features to differentiate between the 3 treatments outcome categories were assessed by One-Way ANOVA test with p-value < 0.05 was to be statistically significant. The results from the analysis were compared with the ones obtained previously for standard Uptake Value (SUV). Results: Based on patients last clinical follow-up; 52 showed NED, 17 AWD and 10 DOD. Radiomics Features were able to classify the patients based on their treatment response. A parallel analysis was done for SUV measurements for comparison. Conclusion: Radiomics features were able to differentiate between the three different classes of treatment outcomes. However, most of the features were only able to differentiate between NED and DOD class. Also, The ability or radiomics features to differentiate types of response were more significant than SUV.

  5. Role of routine imaging in detecting recurrent lymphoma; a review of 258 patients with relapsed aggressive non-Hodgkin and Hodgkin lymphoma

    DEFF Research Database (Denmark)

    El-Galaly, Tarec Christoffer; Mylam, Karen Juul; Bøgsted, Martin

    2014-01-01

    or in combination with abnormal blood tests or physical examination in 64% of the patients. Routine imaging prompted relapse investigations in 27% of the patients. The estimated number of routine scans per relapse was 91-255 depending on the lymphoma subtype. Patients with imaging-detected relapse had lower disease...

  6. Scientific Opinion on the safety of cranberry extract powder as a novel food ingredient pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    products. Considering the composition, manufacturing process, intake, history of consumption of the source and human data, the Panel considers that the data provided do not give reasons for safety concerns. The Panel concludes that the cranberry extract powder is safe as a food ingredient at the proposed...

  7. SU-E-J-258: Inter- and Intra-Fraction Setup Stability and Couch Change Tolerance for Image Guided Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Teboh, Forbang R; Agee, M; Rowe, L; Creasy, T; Schultz, J; Bell, R; Wong, J; Armour, E [Johns Hopkins University, Baltimore, MD (United States)

    2014-06-01

    Purpose: Immobilization devices combine rigid patient fixation as well as comfort and play a key role providing the stability required for accurate radiation delivery. In the setup step, couch re-positioning needed to align the patient is derived via registration of acquired versus reference image. For subsequent fractions, replicating the initial setup should yield identical alignment errors when compared to the reference. This is not always the case and further couch re-positioning can be needed. An important quality assurance measure is to set couch tolerances beyond which additional investigations are needed. The purpose of this work was to study the inter-fraction couch changes needed to re-align the patient and the intra-fraction stability of the alignment as a guide to establish the couch tolerances. Methods: Data from twelve patients treated on the Accuray CyberKnife (CK) system for fractionated intracranial radiotherapy and immobilized with Aquaplast RT, U-frame, F-Head-Support (Qfix, PA, USA) was used. Each fraction involved image acquisitions and registration with the reference to re-align the patient. The absolute couch position corresponding to the approved setup alignment was recorded per fraction. Intra-fraction set-up corrections were recorded throughout the treatment. Results: The average approved setup alignment was 0.03±0.28mm, 0.15±0.22mm, 0.06±0.31mm in the L/R, A/P, S/I directions respectively and 0.00±0.35degrees, 0.03±0.32degrees, 0.08±0.45degrees for roll, pitch and yaw respectively. The inter-fraction reproducibility of the couch position was 6.65mm, 10.55mm, and 4.77mm in the L/R, A/P and S/I directions respectively and 0.82degrees, 0.71degrees for roll and pitch respectively. Intra-fraction monitoring showed small average errors of 0.21±0.21mm, 0.00±0.08mm, 0.23±0.22mm in the L/R, A/P, S/I directions respectively and 0.03±0.12degrees, 0.04±0.25degrees, and 0.13±0.15degrees in the roll, pitch and yaw respectively. Conclusion: The inter-fraction reproducibility should serve as a guide to couch tolerances, specific to a site and immobilization. More patients need to be included to make general conclusions.

  8. Influence of Ultrasonic Treatment on Electromagnetic Characteristicsof Composites Based on Multiwall Carbon Nanotubes at Wide Range of Frequencies (100 Hz – 258 GHz

    Directory of Open Access Journals (Sweden)

    A. Kachusova

    2016-10-01

    Full Text Available In the present paper, we investigated microwave properties of polymer composites based on multiwall carbon nanotubes. The multiwall carbon nanotubes used in the composite were about 9.4 nm and 18.4 nm in diameter. The results show that the ultrasonic treatment modifies the dielectric properties of the composite. The dependence of the real and imaginary parts of the permittivity of sonication time is non linear. The results showed that composite material based on nanotubes with a diameter of 9.4 nm has a dispersive region of dielectric permittivity at the range about 10 GHz.

  9. Association of Clinical Benign Prostate Hyperplasia with Prostate Cancer Incidence and Mortality Revisited: A Nationwide Cohort Study of 3 009 258 Men

    DEFF Research Database (Denmark)

    Ørsted, David Dynnes; Bojesen, Stig E; Nielsen, Sune F;

    2011-01-01

    BACKGROUND: Although benign prostate hyperplasia (BPH) and prostate cancer (PCa) share features such as hormone-dependent growth and response to treatment with antiandrogen therapy, BPH is generally not considered a premalignant lesion. OBJECTIVE: To determine whether clinical BPH is associated...

  10. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

    DEFF Research Database (Denmark)

    Justice, Anne E; Winkler, Thomas W; Feitosa, Mary F

    2017-01-01

    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% Euro...

  11. Galaxy counterparts of metal-rich damped Lyα absorbers: II. A solar-metallicity and dusty DLA at zabs= 2.58

    NARCIS (Netherlands)

    Fynbo, J.P.U.; Ledoux, C.; Noterdaeme, P.; Christensen, L.; Møller, P.; Durgapal, A.K.; Goldoni, P.; Kaper, L.; Krogager, J. -K; Laursen, P.; Maund, J.R.; Milvang-Jensen, B.; Okoshi, K.; Rasmussen, P.K.; Thorsen, T. J.; Toft, S.; Zafar, T.

    2011-01-01

    This is the second paper of a series reporting on the results from a survey conducted with the ESO VLT/X-shooter spectrograph. We target high-metallicity damped Lyman α absorbers (DLAs) with the aim of investigating the relation between galaxies detected in emission and those detected in absorption.

  12. CTD data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 miles north of Oahu, Hawaii for cruises HOT249-258 during 2013 (NODC Accession 0125647)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. The program began in 1988....

  13. Micro-fluidic (Lab-on the- Chip) PCR Array Cartridge for Biological Screening in a Hand Held Device: FInal Report for CRADA no 264. PNNL-T2-258-RU with CombiMatrix Corp

    Energy Technology Data Exchange (ETDEWEB)

    Rainina, Evguenia I.

    2010-10-31

    The worldwide emergence of both new and old diseases resulting from human expansion and also human and materials mobility has and will continue to place stress on both medical and clinical diagnostics. The classical approach to bioagents detection involves the use of differential metabolic assays to determine species type in the case of most bacteria, or the use of cell culture and electron microscopy to diagnose viruses and some bacteria that are intracellular parasites. The long-term goal in bioagent detection is to develop a hand-held instrument featuring disposable cartridges which contain all the necessary reagents, reaction chambers, waste chambers, and micro-fluidics to extract, concentrate, amplify, and analyze nucleic acids. This GIPP project began development of a sensory platform using nucleic-acid based probes. Although research was not completed, initial findings indicated that an advanced sensing device could theoretically be built on a DNA/RNA-based technology platform.

  14. BORIC-ACID MEDIATED PREPARATION OF MESOCYCLIC THIOCROWN ETHERS CONTAINING XYLYLENE UNITS - MOLECULAR-STRUCTURES OF 3,8-DIBENZO-1,6-DITHIACYCLODECANE AND 2,5,8-TRITHIA-(9)-P-BENZENOPHANE

    NARCIS (Netherlands)

    EDEMA, JJH; STOCK, HT; KELLOGG, RM; SMEETS, WJJ; SPEK, AL

    1993-01-01

    Reaction of a dithiol with B(OH)3 and base in MeOH followed by reaction with xylylene dibromides proceeds selectively to give the corresponding ortho, meta or para-cyclophanes in good yield (70-86 %). The syntheses of examples of all three types of benzenophanes are discussed. The molecular structur

  15. Historical keys of political regime in Paraguay. Lopez and Stroessner - doi: 10.4025/dialogos.v11i1e2.58 Claves históricas del régimen político en Paraguay. López y Stroessner Claves históricas del régimen político en Paraguay. López y Stroessner - doi: 10.4025/dialogos.v11i1e2.58

    Directory of Open Access Journals (Sweden)

    Lorena Soler

    2010-05-01

    Full Text Available This article aims at tracking the political traditions inaugurated with the Triple Alianza war, reinvigorated in the 1940s and 1950s with the impossibility of constitution of a liberal democratic regime but also with the limitations of the economic regime, which had been created as a result of the Guerra Grande. In this sense, the article develops and shows, in a long term perspective, the changes in the State and the Nation from the beginning of the Independent Republic, to Stroessner’s dictatorship and to the current process of transition to political democracy. The central question is how the constitution of a State and the invention of a Nation accompanied by the always possible Triple Alianza war, fostered a lot of representations and political images that, being available and with the Guerra del Chaco, resulted of major efficacy to the stronista dictatorship and which can give explicatory keys of structural and political problems of the present democracy.El artículo se propone rastrear tradiciones políticas inauguradas con la Guerra de la Triple Alianza y revalorizadas en la década de 1940 y 1950 ante la imposibilidad de constitución de un régimen liberal democrático pero también de las limitaciones del régimen económico, al que precisamente los resultados de la Guerra Grande habían dado origen. En tal sentido, desarrolla y demuestra, en líneas de larga duración, las modificaciones del Estado y la Nación desde los inicio de la República Independiente pasando por la dictadura de Strossner para llegar al actual proceso de transición a la democracia política. La hipótesis central es ver cómo la constitución de un Estado y la invención de una Nación al compás de la siempre posible Guerra de la Triple Alianza, propiciaron un conjunto de representaciones e imágenes políticas que, en disponibilidad y Guerra del Chaco mediante, resultaron de suma eficacia para la dictadura stronista y sobre las cuales pueden encontrarse claves explicativas sobre problemas estructurales y políticos actuales de la democracia.Este artigo busca identificar as políticas inauguradas com a Guerra da Tríplice Aliança y recuperadas durante as décadas de 1940 e 1950 perante a impossibilidade da constituição de um regime liberal democrático e pelas limitações do regime econômico, originadas nas conseqüências da Grande Guerra. Neste sentido, aqui são analisadas as modificações do Estado y da Nação desde os começos da República Independente, passando pela ditadura de Stroessner até chegar ao atual processo de transição à democracia política, em linhas de longa duração. A principal hipótese deste artigo é ver como a constituição de um Estado e a invenção de uma Nação – ao ritmo da Guerra da Tríplice Aliança - favoreceram um conjunto de representações e imagens políticas que resultaram de suma eficácia para a ditadura stronista e sobre as quais é possível encontrar as chaves que explicam os problemas estruturais e políticos atuais da democracia.

  16. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFC258 (Link to dictyBase) - - - Contig-U13874-1 VFC258P (Link... to Original site) VFC258F 358 VFC258Z 382 VFC258P 740 - - Show VFC258 Library VF (Link to library) Clone ID VFC258 (Link to di...ctyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U13874-1 Original site URL http://di... B: vgllxyqwtiqsynndnfhxi*hh*kdlyndlishietlrkkkgseysvadyqiligeqr tveflskivsneteflfkeckdsdkdi...0 %: plasma membrane 4.0 %: peroxisomal >> prediction for VFC258 is cyt 5' end seq. ID VFC258F 5' end seq. >

  17. Chemical studies of elements with Z ≥ 104 in liquid phase

    Energy Technology Data Exchange (ETDEWEB)

    Nagame, Yuichiro, E-mail: nagame.yuichiro@jaea.go.jp [Advanced Science Research Center, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Kratz, Jens Volker [Institut für Kernchemie, Johannes Gutenberg-Universität Mainz, Fritz-Straßmann-Weg 2, 55128 Mainz (Germany); Schädel, Matthias [Advanced Science Research Center, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan)

    2015-12-15

    Recent studies of the chemical separation and characterization experiments of the first three transactinide elements, rutherfordium (Rf), dubnium (Db), and seaborgium (Sg), conducted atom-at-a-time in liquid phases, are reviewed. A short description on experimental techniques based on partition methods, specifically automated rapid chemical separation systems, is also given. A newly developed experimental approach to investigate single atoms of the heaviest elements with an electrochemical method is introduced. Perspectives for liquid-phase chemistry experiments on heavier elements are briefly discussed.

  18. 用于流动注射分析悬浮液中的试剂。天然水中硫酸根的光谱测定Cmkovic,Paula Manoel等(Brazil)Quimica Nova 2002,25(2),254~258(葡萄牙文)

    Institute of Scientific and Technical Information of China (English)

    纪永亮

    2004-01-01

    本文讨论了在流动注射分析中使用一种浆状试剂的自动分析方法。通过采用氯冉酸钡法测定水中的硫酸根证明了该建议的可行性,氯冉酸钡法是以硫酸钡的沉淀为基础的。高度着色的氯冉酸根离子的释放在528nm处被监测。反应在醇介质中进行,

  19. Corrigendum to "The 16 April 2016, MW 7.8 (MS 7.5) Ecuador earthquake: A quasi-repeat of the 1942 MS 7.5 earthquake and partial re-rupture of the 1906 MS 8.6 Colombia-Ecuador earthquake" [Earth Planet. Sci. Lett. 454 (2016) 248-258

    Science.gov (United States)

    Ye, Lingling; Kanamori, Hiroo; Avouac, Jean-Philippe; Li, Linyan; Cheung, Kwok Fai; Lay, Thorne

    2017-01-01

    In response to inquiries from readers of the paper, we have reexamined the time series recorded at DART 32067 and confirmed the existence of a data gap in the recording between 19 and 34 min after the earthquake initiation time. The recorded time series also includes short-period ground oscillations and long-period tidal fluctuations. We originally had run the records through a script that re-sampled the data to uniform intervals and filtered out the tidal signals. This inadvertently interpolated across the data gap and distorted the signal. We misinterpreted the interpolated feature as the second arrival of the recorded tsunami in the top panel of Figs. 3e, S3e, and S4e. The recorded waveform in the corrected version of Fig. 3e appended herein has instead been de-tided using the OTIS Regional Tidal Solutions (http://volkov.oce.orst.edu/tides/PO.html).

  20. Validation of a Protocol to Compare the Effectiveness of Experimental Decontaminants with Component 2 of the M258A1 Kit or Fuller’s Earth Standard Decontaminants Against Percutaneous Application of Undiluted Vesicant Chemical Surety Materiel to the Laboratory Albino Rabbit

    Science.gov (United States)

    1987-07-24

    extensive data base available for percutaneous application of toxic materials in this species and on the size of the application area for multiple...transported to the MREF. Upon receipt at the Animal Resources Facility, the rabbits were ear tattooed for positive identification, weighed, sexed, and...Dermal Toxicity . In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Edited and published by The Association of Food and Drug

  1. The Launch of a Joint Library/Writing Centre Online Course on Academic Integrity. A Review of: Greer, K., Swanberg, S., Hristova, M., Switzer, A. T., Daniel, D., & Perdue, S. W. (2012. Beyond the web tutorial: Development and implementation of an online, self-directed academic integrity course at Oakland University. The Journal of Academic Librarianship, 38(5, 251-258.

    Directory of Open Access Journals (Sweden)

    Cari Merkley

    2013-06-01

    Full Text Available Objective – To outline the collaborative development of an online course addressing academic integrity by a university’s library system and writing centre.Design – Case study.Setting – A public research university in the Midwestern United States.Subjects – 1650 students who completed the online module.Methods – Oakland University (OU Libraries and the Writing Centre began to collaborate on the development of a new online course on academic integrity in 2011. It was felt that an existing online library tutorial on plagiarism no longer met the needs of students and faculty. The development of the course was informed by the Association of College and Research Libraries’ Information Literacy Competency Standards for Higher Education (2000 as well as a research study investigating students’ use of sources in their scholarly writing across several institutions. Moodle, the institution’s learning management system (LMS, was used to develop the learning object.Main Results – OU Libraries and the Writing Centre launched the six-part online course entitled “Using and Citing Sources” in January 2012. They developed modules around learning outcomes in five broad categories: defining academic integrity and plagiarism; the use of sources in academic writing; paraphrasing; quoting; and citation. The final module provided students with an opportunity to practise lessons learned in the first five modules. The use of the LMS to design and host the course limited the tutorial to registered students, but provided developers with access to additional course functionality without labour-intensive coding. It also allowed Writing Centre staff to access students’ performance data on the modules prior to their appointments. Improvements over the previous online tutorial included expanded content on academic ethics and referencing, more active learning elements, video content, and the opportunity for students to choose discipline-specific examples. In the first four months of its availability, 1650 students completed the course, with 3330 attempts overall.Conclusion – The diverse perspectives and expertise that individuals from OU Libraries and the Writing Center brought to their collaboration greatly informed the development of the course. The time and effort saved by using the university’s existing LMS to develop interactive content and the focus on providing students with opportunities for active learning within the course contributed to the project’s success.

  2. Park Land and Nature Preserves, Aquatic Preserves Aquatic Preserves are state-owned sovereign submerged lands in areas which have exceptional biological, aesthetic, and scientific value, as described in Chapter 258.39, Florida Statutes, which have been set aside for the benefit of futur, Published in 2011, 1:24000 (1in=2000ft) scale, Florida Department of Environmental Protection.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Park Land and Nature Preserves dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2011. It is described...

  3. CCDC 974613: Experimental Crystal Structure Determination : catena-[bis(mu-5,5',5''-(1,3,4,6,7,9,9b-heptaazaphenalene-2,5,8-triyltriimino)triisophthalato)-tris(dimethyl sulfoxide)-triaqua-hexa-copper dimethyl sulfoxide solvate hydrate

    KAUST Repository

    Luebke, Ryan

    2014-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  4. Gclust Server: 41309 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 41309 PoTR_564183 Cluster Sequences Related Sequences(258) 169 eugene3.00080778 2 1...ces Cluster Sequences Link to related sequences Related Sequences(258) Sequence length 169 Representative annotation eugene

  5. 76 FR 13524 - Radio Broadcasting Services; Willow Creek, CA

    Science.gov (United States)

    2011-03-14

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Willow Creek, CA AGENCY: Federal Communications... FM Channel 258A at Willow Creek, California. Channel 258A can be allotted at Willow Creek, consistent... of FM Allotments under California, is amended by adding Channel 258A at Willow Creek....

  6. Dicty_cDB: Contig-U15642-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available packaging cell line, compositi... 258 0.0 5 ( BD021940 ) Packaging cell systems for use in promotion of th....., compositi... 258 0.0 5 ( BD021943 ) Packaging cell systems for use in promotion of th... 258 0.0 5 ( AX356

  7. Protein (Cyanobacteria): 256632 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available ZP_18822282.1 1117:4719 1118:2876 1125:3064 1126:3543 1160286:258 H(+)/Cl(-) exchan...ATLFSLGLAQVCDAWFPGQLPQPGVFAVAGMGGLVAATVRAPLTAVMLVMELTDNFLVALPILLTCICAAITAHFLGGEPVYSVLLKRILDKLERQPPSDRI ...

  8. School of Advanced Military Studies Research Catalog, AY 1983 - 1984 Through AY 1993 - 1994

    Science.gov (United States)

    1994-01-01

    Every Clime and 258 098 Place: USMC Cold Weather Training Doc- trine ADA 251 427 Major Kevin Anastas , Information Overflow: Tactical Information...Major John E. Sterling. Obstacle "Theory": Do We Need It? ADA 258 249 Major Kevin Anastas , The American Way of Operational Art: Attrition or Maneuver

  9. High-Temperature Ferromagnetism in Cr- and Mn-Implanted Al(sub x)Ga(sub 1-x)N

    Science.gov (United States)

    2007-09-23

    Uspenskii , E. Kulatov, H. Mariette, H. Nakayama, H. Ohta, J. Magnetism and Magnetic Mat. 258-259, 248 (2003). [4] T. Dietl, Semicon. Science and Tech...287 (2000) 1019–1022. [3] Y. Uspenskii , E. Kulatov, H. Mariette, H. Nakayama, H. Ohta, J. Magn. Magn. Mater. 258–259 (2003) 248–250. [4] T. Dietl

  10. Dicty_cDB: Contig-U16267-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 8208 ) Adenovirus vector, packaging cell line, compositi... 258 e-160 4 ( BD021940 ) Packaging cell systems for use in promotion...ng cell systems for use in promotion of th... 258 e-159 4 ( AX356044 ) Sequence 1

  11. 10 CFR Appendix L to Part 110 - Illustrative List of Byproduct Materials Under NRC Export/Import Licensing Authority a

    Science.gov (United States)

    2010-01-01

    ...) Manganese 52 (Mn 52) Manganese 54 (Mn 54) Manganese 56 (Mn 56) Mendelevium 258 (Md 258) Mercury 197m (Hg... 182 (Ta 182) Technetium 96 (Tc 96) Technetium 97m (Tc 97m) Technetium 97 (Tc 97) Technetium 99m (Tc 99m) Technetium 99 (Tc 99) Tellurium 125m (Te 125m) Tellurium 127m (Te 127m) Tellurium 127 (Te 127...

  12. AcEST: DK948904 [AcEST

    Lifescience Database Archive (English)

    Full Text Available sp|P34113|RL3_DICDI 60S ribosomal protein L3 OS=Dictyostelium di... 258 2e-68 sp|P49149|RL3_TOXCA 60S ribosomal protein L3 OS=Toxoca...ra canis G... 258 2e-68 sp|P50880|RL3_CAEEL 60S ribosomal protein L3 OS=Caenorhabdi

  13. AcEST: BP921304 [AcEST

    Lifescience Database Archive (English)

    Full Text Available : 258 QVEKLMNFWATVLLGKKFHYDQYVENQTKFVSQAAWFSKSIDCQNLAGKEAVVFGDATHA 317 Query: 163 ASITKILSGEMGIRVSCSGTYCKHDA...GRFNEQVQGLCDEVIITEDHTEVGDTIA 2 ASITKILSGEMGIRVSCSGTYCKHDAG FNEQVQGLCDEVIITEDHTEVGDTIA Sbjct: 318 ASITKILSGEMGIRVSCSGTYC...DATHA 317 Query: 163 ASITKILSGEMGIRVSCSGTYCKHDAGRFNEQVQGLCDEVIITEDHTEVGDTIA 2 ASITKIL+ EMGIRVSC+GTYCKHD F EQ...VQ CDE++IT+DHTEVGD IA Sbjct: 318 ASITKILACEMGIRVSCTGTYCKHDEEWFREQVQNFCDEILITDDHTE...Sbjct: 258 QIQKRVNTWTHFLLNQKLDYELYIDQQTRFISQAAWFSRSIDCQNLTGKKAVVFGDATHA 317 Query: 163 ASITKILSGEMGIRVSCSGTYC

  14. Domain Modeling: NP_002932.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_002932.1 chr3 DROSOPHILA ROBO IG1-2 (MONOCLINIC FORM) p2vrad_ chr3/NP_002932.1/NP_002932....1_apo_68-258.pdb p2vrab_ chr3/NP_002932.1/NP_002932.1_holo_68-258.pdb blast 81K,131R,132I,133V,134H

  15. Drug: D02912 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02912 Drug Amiquinsin hydrochloride (USAN) C11H12N2O2. HCl. H2O 258.0771 258.7014 D02912.gif Antihypertensi...ve CAS: 7125-70-4 PubChem: 17397069 LigandBox: D02912 ATOM 17 1 C8y C 23.3446 -18.0

  16. 75 FR 8986 - Draft Supplemental Environmental Impact Statement for the Proposed Campo Regional Landfill...

    Science.gov (United States)

    2010-02-26

    ... constructing and operating a solid waste landfill, recycling facility, and composting facility. In 1989, the... be required to comply with 40 CFR part 258 (Criteria for Municipal Solid Waste Landfills). Because... 258. For municipal solid waste landfills in Indian Country, the EPA must makes...

  17. Capabilities, Learning and the Nature of the Firm

    DEFF Research Database (Denmark)

    Knudsen, Thorbjørn; Hodgson, Geoffrey M.

    2007-01-01

      Knudsen, Thorbjørn (2007) with Geoffrey M. Hodgson, "Capabilities, Learning and the Nature of the Firm", Revue Economique, 2(58), pp. 331-350.......  Knudsen, Thorbjørn (2007) with Geoffrey M. Hodgson, "Capabilities, Learning and the Nature of the Firm", Revue Economique, 2(58), pp. 331-350....

  18. National Information Centre for Marine Sciences (NICMAS) - An excellent source of information for aquaculturists

    Digital Repository Service at National Institute of Oceanography (India)

    Tapaswi, M.P.

    stream_size 4 stream_content_type text/plain stream_name Proc_Natl_Workshop_Aquacult_WeeK_1998_258.pdf.txt stream_source_info Proc_Natl_Workshop_Aquacult_WeeK_1998_258.pdf.txt Content-Encoding ISO-8859-1 Content-Type text...

  19. Drug: D08178 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08178 Drug Menbutone (INN); Genabiline [veterinary] (TN) C15H14O4 258.0892 258.269...3 D08178.gif Choleretic veterinary medicine CAS: 3562-99-0 PubChem: 96024868 LigandBox: D08178 NIKKAJI: J8.1

  20. Evaluation of the toxicity of organic matter in marine sediments

    Digital Repository Service at National Institute of Oceanography (India)

    Sarkar, A.

    stream_size 3 stream_content_type text/plain stream_name 2_Int_Conf_Waste_Mgmt_Chem_Petrochem_Ind_Toxic_Mgmt_1991_258.pdf.txt stream_source_info 2_Int_Conf_Waste_Mgmt_Chem_Petrochem_Ind_Toxic_Mgmt_1991_258.pdf.txt Content...

  1. Two Serine Residues Control Sequential Steps during Catalysis of the Yeast Copper ATPase through Different Mechanisms That Involve Kinase-mediated Phosphorylations*

    Science.gov (United States)

    Valverde, Rafael H. F.; Britto-Borges, Thiago; Lowe, Jennifer; Einicker-Lamas, Marcelo; Mintz, Elisabeth; Cuillel, Martine; Vieyra, Adalberto

    2011-01-01

    Ccc2, the yeast copper-transporting ATPase, pumps copper from the cytosol to the Golgi lumen. During its catalytic cycle, Ccc2 undergoes auto-phosphorylation on Asp627 and uses the energy gained to transport copper across the cell membrane. We previously demonstrated that cAMP-dependent protein kinase (PKA) controls the energy interconversion CuE∼P → E-P + Cu when Ser258 is phosphorylated. We now demonstrate that Ser258 is essential in vivo for copper homeostasis in extremely low copper and iron concentrations. The S258A mutation abrogates all PKA-mediated phosphorylations of Ccc2, whereas the S971A mutation leads to a 100% increase in its global regulatory phosphorylation. With S258A, the first-order rate constant of catalytic phosphorylation by ATP decreases from 0.057 to 0.030 s−1, with an 8-fold decrease in the burst of initial phosphorylation. With the S971A mutant, the rate constant decreases to 0.007 s−1. PKAi5–24 decreases the amount of the aspartylphosphate intermediate (EP) in Ccc2 wt by 50% within 1 min, but not in S258A, S971A, or S258A/S971A. The increase of the initial burst and the extremely slow phosphorylation when the “phosphomimetic” mutant S258D was assayed (k = 0.0036 s−1), indicate that electrostatic and conformational (non-electrostatic) mechanisms are involved in the regulatory role of Ser258. Accumulation of an ADP-insensitive form in S971A demonstrates that Ser971 is required to accelerate the hydrolysis of the E-P form during turnover. We propose that Ser258 and Ser971 are under long-range intramolecular, reciprocal and concerted control, in a sequential process that is crucial for catalysis and copper transport in the yeast copper ATPase. PMID:21163943

  2. Chemistry of the superheavy elements.

    Science.gov (United States)

    Schädel, Matthias

    2015-03-13

    The quest for superheavy elements (SHEs) is driven by the desire to find and explore one of the extreme limits of existence of matter. These elements exist solely due to their nuclear shell stabilization. All 15 presently 'known' SHEs (11 are officially 'discovered' and named) up to element 118 are short-lived and are man-made atom-at-a-time in heavy ion induced nuclear reactions. They are identical to the transactinide elements located in the seventh period of the periodic table beginning with rutherfordium (element 104), dubnium (element 105) and seaborgium (element 106) in groups 4, 5 and 6, respectively. Their chemical properties are often surprising and unexpected from simple extrapolations. After hassium (element 108), chemistry has now reached copernicium (element 112) and flerovium (element 114). For the later ones, the focus is on questions of their metallic or possibly noble gas-like character originating from interplay of most pronounced relativistic effects and electron-shell effects. SHEs provide unique opportunities to get insights into the influence of strong relativistic effects on the atomic electrons and to probe 'relativistically' influenced chemical properties and the architecture of the periodic table at its farthest reach. In addition, they establish a test bench to challenge the validity and predictive power of modern fully relativistic quantum chemical models.

  3. The Rhizobium etli rpoN Locus: DNA Sequence Analysis and Phenotypical Characterization of rpoN, ptsN, and ptsA Mutants

    OpenAIRE

    Michiels, Jan; Van Soom, Tom; D’hooghe, Inge; Dombrecht, Bruno; Benhassine,Traki; Wilde, Petra; Vanderleyden, Jos

    1998-01-01

    The rpoN region of Rhizobium etli was isolated by using the Bradyrhizobium japonicum rpoN1 gene as a probe. Nucleotide sequence analysis of a 5,600-bp DNA fragment of this region revealed the presence of four complete open reading frames (ORFs), ORF258, rpoN, ORF191, and ptsN, coding for proteins of 258, 520, 191, and 154 amino acids, respectively. The gene product of ORF258 is homologous to members of the ATP-binding cassette-type permeases. ORF191 and ptsN are homologous to conserved ORFs f...

  4. The Rhizobium etli rpoN Locus: DNA Sequence Analysis and Phenotypical Characterization of rpoN, ptsN, and ptsA Mutants

    OpenAIRE

    Michiels, Jan; Van Soom, Tom; D’hooghe, Inge; Dombrecht, Bruno; Benhassine, Traki; Wilde, Petra; Vanderleyden, Jos

    1998-01-01

    The rpoN region of Rhizobium etli was isolated by using the Bradyrhizobium japonicum rpoN1 gene as a probe. Nucleotide sequence analysis of a 5,600-bp DNA fragment of this region revealed the presence of four complete open reading frames (ORFs), ORF258, rpoN, ORF191, and ptsN, coding for proteins of 258, 520, 191, and 154 amino acids, respectively. The gene product of ORF258 is homologous to members of the ATP-binding cassette-type permeases. ORF191 and ptsN are homologous to conserved ORFs f...

  5. 249 The Effect of Inter-tribal Post Election Violence Conflict Trauma ...

    African Journals Online (AJOL)

    User

    School Students in Mt. Elgon District, Kenya. (Pp. 249-258). Nasongo, B. ... result of inter-ethnic conflicts on academic performance among secondary .... distress and depression in terms of irritability, anger and increased alcohol consumption.

  6. The Fullness of the Logos of Life and the Comprehending of the “Sacral Logos” on the Horizon of Life

    Directory of Open Access Journals (Sweden)

    Carmen Cozma

    2010-11-01

    Full Text Available Book review to: Anna-Teresa Tymieniecka. The Fullness of the Logos in the Key of Life. Book I: The Case of God in the New Enlightenment. Analecta Husserliana, Volume C. Dordrecht: Springer, 2009. Pp. xxxv + 258

  7. Young Children's Mathematics References during Free Play in Family Childcare Settings

    Science.gov (United States)

    Hendershot, Shawnee M.; Berghout Austin, Ann M.; Blevins-Knabe, Belinda; Ota, Carrie

    2016-01-01

    Very little is known about children's discussion of mathematics topics during unstructured play. Ginsburg, Lin, Ness, and Seo [2003. Young American and Chinese children's everyday mathematical activity. Mathematical Thinking and Learning, 5(4), 235-258. Retrieved from…

  8. Protein (Cyanobacteria): 197732 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available ZP_01083417.1 1117:3837 1118:1190 1129:258 69042:4 ABC-type transport system involved in resistance to organ...icsolvents ATPase component Synechococcus sp. WH 5701 MNHSPPIAPDGPVLELDGVGMRWGSNIVL

  9. Teise samba tegijad lähevad stabiliseerimisvaru kallale / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2001-01-01

    Riik peab pensionisüsteemi teise samba käivitamiseks minema stabiliseerimisreservi miljardi krooni kallale, seda eriti juhul, kui ühtaegu tõstetakse ka riiklikku pensioni. Stabiliseerimisreserv täienes eelmisel aastal 258 miljoni krooniga

  10. Cribrarione B, a new naphthoquinone pigment from the myxomycete Cribraria cancellata.

    Science.gov (United States)

    Iwata, Dai; Ishibashi, Masami; Yamamoto, Yukinori

    2003-12-01

    Cribrarione B (1), a new naphthoquinone pigment, has been isolated from the myxomycete Cribrariacancellata, and its structure was elucidated as 2,5,8-trihydroxy-6-(1-hydroxyethyl)-[1,4]-naphthoquinone by NMR and mass spectral data.

  11. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Manatee County

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — The RGB/CIR half-foot orthophotos to be mapped consists of 2,258 cells (approximately 2,025 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  12. AY Bala, T. Adamu, U. Abubakar, MJ Ladan and MG Abubakar

    African Journals Online (AJOL)

    acer

    KEYWORDS: in vitro, trypanocidal activity, medicinal plants, sokoto, Nigeria. INTRODUCTION ... Studies on the In Vitro Trypanocidal Effect of the Extracts of Some Selected Medicinal Plants in …….. 258 ..... Planta Medica, 62: 98-105. Tropical ...

  13. Determining the quality of competences assessment programs: A self-evaluation procedure

    NARCIS (Netherlands)

    Baartman, Liesbeth; Prins, Frans; Kirschner, Paul A.; Van der Vleuten, Cees

    2009-01-01

    Baartman, L. K. J., Prins, F. J., Kirschner, P. A., & Van der Vleuten, C. P. M. (2007). Determining the quality of Competence Assessment Programs: A self-evaluation procedure. Studies in Educational Evaluation, 33, 258-281.

  14. Determining the quality of competences assessment programs: A self-evaluation procedure

    NARCIS (Netherlands)

    Baartman, Liesbeth; Prins, Frans; Kirschner, Paul A.; Van der Vleuten, Cees

    2009-01-01

    Baartman, L. K. J., Prins, F. J., Kirschner, P. A., & Van der Vleuten, C. P. M. (2007). Determining the quality of Competence Assessment Programs: A self-evaluation procedure. Studies in Educational Evaluation, 33, 258-281.

  15. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Manatee County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR half-foot orthophotos to be mapped consists of 2,258 cells (approximately 2,025 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  16. Anvisning om Bygningsreglement 2015

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Ginnerup, Søren; Stang, Birgitte Friis Dela;

    Anvisningen forklarer og fortolker bestemmelserne i Bygningsreglement 2015 (BR15). SBi-anvisning 258 har samme kapitelstruktur som BR15, og anvisningsteksten ledsages af den fulde reglements- og vejledningstekst. Desuden henviser anvisningen til relevante standarder, andre anvisninger og andet...

  17. Paediatric HIV/AIDSin Abakaliki

    African Journals Online (AJOL)

    immunodeficiency syndrome (AIDS) were described treatment, a vast majority ..... Eight children (25.8 percent) had suppurative otitis media, which persisted despite appropriate treatment. .... surveillance systems fall short of the optimum, and.

  18. Head Trauma: First Aid

    Science.gov (United States)

    ... 258&terms=cpr. Accessed Oct. 8, 2014. Traumatic brain injury. The Merck Manual Professional Edition. http://www.merckmanuals.com/professional/injuries_poisoning/traumatic_brain_injury_tbi/traumatic_brain_injury.html. Accessed Oct. 8, ...

  19. Estimating Magic Numbers Larger Than 126 by Fermi-Yang Liming Method

    Institute of Scientific and Technical Information of China (English)

    LI Xian-Hui; ZHOU Zhi-Ning; ZHONG Yu-Shu; YANG Ze-Sen

    2001-01-01

    The Fermi Yang Liming method is followed and developed to estimate new magic numbers in nuclei with a Woods Saxon density function. The calculated results predict that the magic number next to 126 should be around 184 and 258.

  20. Profile temperature data collected from XBT aboard the Safmarine Meru on the PX05 transect in the Pacific Ocean from 27 October 2012 to 5 November 2012 (NODC Accession 0100523)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0100523 contains 258 temperature profiles collected from Expendable Bathythermographs (XBT) aboard the Safmarine Meru in the Pacific Ocean, Coral Sea,...

  1. 40 CFR 257.5 - Disposal standards for owners/operators of non-municipal non-hazardous waste disposal units that...

    Science.gov (United States)

    2010-07-01

    ... defined in 40 CFR 261.5. Non-municipal non-hazardous waste disposal units that meet the requirements of... permit program for 40 CFR part 257, subpart B and 40 CFR part 258 regulated facilities. Uppermost...

  2. the physical fibre properties of gonometa postica after degumming ...

    African Journals Online (AJOL)

    user

    Wild silkworm farming is a unique industry with a great potential ... appeared on the European markets. ..... treatment and replicate, the ratio ( ) of “after” ..... Journal of Biological Macromolecules, 38, 255-. 258. .... from silk industry wastewater.

  3. Estimating Domestic Self-Supply Water Use for the Delaware River Basin, 2010 U.S. Census Block Groups

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — According to the U.S. Geological Survey, an estimated 258 million people nationwide, or 86% of the U.S. population, relied on public water supplies for their...

  4. VizieR Online Data Catalog: Mass limits on substellar companions (Reffert+, 2011)

    Science.gov (United States)

    Reffert, S.; Quirrenbach, A.

    2011-08-01

    We fitted the astrometric orbits of 310 substellar companions around 258 stars, which were all discovered via the radial velocity method, to the Hipparcos intermediate astrometric data provided by van Leeuwen (2007, Astrophys. Space Library 350). (2 data files).

  5. Determination of Content of Phenylalanine by Double-wavelength UV Spectrophotometric Method%双波长紫外吸收法测定L-苯丙氨酸含量

    Institute of Scientific and Technical Information of China (English)

    项雷文; 郑建兵

    2002-01-01

    采用双波长紫外吸收法测定转化液中L-苯丙氨酸含量,测定波长为258 nm,参比波长为278 nm.由Acr278=138.18C+0.0085 γ=0.9995得到肉桂酸浓度Cr,再由A258=ACr258+Acp258=76.531Cr+.9446Cp+0.0366,计算出L-苯丙氨酸含量Cp.此方法快速、简便、准确度高、除杂效果好,适用于生产过程控制.

  6. Estimating Domestic Self-Supply Water Use for the Delaware River Basin, 1990 U.S. Census Block Groups

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — According to the U.S. Geological Survey, an estimated 258 million people nationwide, or 86% of the U.S. population, relied on public water supplies for their...

  7. Estimating Domestic Self-Supply Water Use for the Delaware River Basin, 2000 U.S. Census Block Groups

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — According to the U.S. Geological Survey, an estimated 258 million people nationwide, or 86% of the U.S. population, relied on public water supplies for their...

  8. Estimating Domestic Self-Supply Water Use for the Delaware River Basin, 1990 U.S. Census Blocks

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — According to the U.S. Geological Survey, an estimated 258 million people nationwide, or 86% of the U.S. population, relied on public water supplies for their...

  9. Estimating Domestic Self-Supply Water Use for the Delaware River Basin, 2000 U.S. Census Blocks

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — According to the U.S. Geological Survey, an estimated 258 million people nationwide, or 86% of the U.S. population, relied on public water supplies for their...

  10. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Sarasota County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR half-foot orthophotos to be mapped consists of 2,258 cells (approximately 2,025 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  11. Organic 'compensatory' osmolytes in osmolarity control and ...

    African Journals Online (AJOL)

    1997-09-02

    Sep 2, 1997 ... In animal cells, which lack rigid and highly resistant walls, cell osmoregulation is .... been identifIed as major organic osmolytes in animal cells. (Figure 3). ...... and betaine in mammalian cells in culture. Am. J. Physiol. 258:.

  12. -ADIPOSITY IN NIGERIANS WITH TYPE 2 DIABETES MELLITUS

    African Journals Online (AJOL)

    2006-05-03

    May 3, 2006 ... disorders with other components of the metabolic syndrome culminate in an increase in macrovascular and microvascular complications ... The prevalence of obesity in this cohort of type 2 DM was 18.6% (48 of 258) overall.

  13. Psychosocial Stress Among Patients With Type 2 Diabetes: Habitual ...

    African Journals Online (AJOL)

    USER

    University College Hospital (UCH) or the State Hospital, ... time sporting activity, duration of sporting activity etc; while the leisure ..... Science in Sports Exercise 33: 255–258. ... patients: The relationship between mood and glycemic control.

  14. MORPHOLOGICAL REPRESENTATION AND SEMANTIC ...

    African Journals Online (AJOL)

    The morphological representation assigned to a complex word must provide the formal structure .... This brings us to the cases where, on Williams's (1981a:258) analysis, the compositional notion ...... Die en moda Ii tei t . Kaaps tad: Ba 1 kema.

  15. 31 CFR 8.51 - Authority to disbar or suspend.

    Science.gov (United States)

    2010-07-01

    ... BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.51 Authority to disbar or suspend... or prospective client, by word, circular, letter, or by advertisement. (Sec. 3, 23 Stat. 258 (31...

  16. (1) pp. 38-46, June, 2010 Original Paper

    African Journals Online (AJOL)

    2010-06-01

    Jun 1, 2010 ... Original Paper. Care Seeking Determinants among Adolescents in Lagos, Nigeria .... youth participation, evidence based treatment, ... Islam. 1678. 27.6. Ethnicity. Igbo. 1009. 16.6. Yoruba. 1569. 25.8 ..... South East, Nigeria.

  17. Effectiveness of an online SUpport PRogramme (SUPR) for older hearing aid users: study protocol for a cluster randomised controlled trial

    National Research Council Canada - National Science Library

    Janine FJ Meijerink; Marieke Pronk; Bernadette Paulissen; Birgit I Witte; Bregje van der Wouden; Vera Jansen; Sophia E Kramer

    2017-01-01

    ... (care as usual, 34 practices) and hearing aid fitting including SUPR (36 practices). The aim was to recruit a total of 569 older (aged 50+ years) first-time (n=258) and experienced (n=311) HAUs and their CPs...

  18. NCBI nr-aa BLAST: CBRC-CREM-01-0200 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CREM-01-0200 ref|NP_503686.1| Seven TM Receptor family member (str-258) [Caenorhabditis elegans...] ref|NP_503659.2| Y19D10A.2 [Caenorhabditis elegans] gb|AAK68415.2|AC006722_7 Hypothetical... protein Y19D10A.2 [Caenorhabditis elegans] gb|AAD14695.1| Seven tm receptor protein 258 [Caenorhabditis elegans] NP_503686.1 3e-95 53% ...

  19. 77 FR 18651 - Qualifying Urban Areas for the 2010 Census

    Science.gov (United States)

    2012-03-27

    ...*.. 58,875 Lexington-Fayette, KY 290,263 Lima, OH 72,852 Lincoln, NE 258,719 Little Rock, AR 431,388... Marcos, TX 52,826 Santa Barbara, CA 195,861 Santa Clarita, CA 258,653 Santa Cruz, CA 163,703 Santa Fe, NM 89,284 Santa Maria, CA 130,447 Santa Rosa, CA 308,231 Sarasota--Bradenton, FL 643,260...

  20. Domain Modeling: NP_001078937.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001078937.1 chr11 Viral proteases d1kxfa_ chr11/NP_001078937.1/NP_001078937.1_ap...o_114-258.pdb d1wyka_ chr11/NP_001078937.1/NP_001078937.1_holo_114-258.pdb swppa 119G,120Y,121P,122G,140Y,141R,145E,184D,188M,253R DIO,FOR 1 ...

  1. 78 FR 57445 - Fiscal Year 2014 WTO Tariff-Rate Quota Allocations for Raw Cane Sugar, Refined and Specialty...

    Science.gov (United States)

    2013-09-18

    ... Guatemala 50,546 Guyana 12,636 Haiti 7,258 Honduras 10,530 India 8,424 Jamaica 11,584 Madagascar 7,258... specialty sugars. USTR is allocating 12,050 MTRV of refined sugar to Canada and 8,294 MTRV of refined sugar... under Additional U.S. Note 8 to Chapter 17 of the HTS, USTR is allocating 59,250 MT to Canada....

  2. Drug: D07160 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07160 Drug Cloridarol (INN) C15H11ClO2 258.0448 258.6996 D07160.gif Anticoagulant ...9 11 2 12 11 12 1 13 12 13 1 14 13 14 1 15 9 14 1 16 12 15 2 17 15 16 1 18 16 17 2 19 17 18 1 20 13 18 2 InChI=1S/C15H11ClO2

  3. First Isolate of KPC-2-Producing Klebsiella pneumonaie Sequence Type 23 from the Americas

    Science.gov (United States)

    Cejas, Daniela; Fernández Canigia, Liliana; Rincón Cruz, Giovanna; Elena, Alan X.; Maldonado, Ivana; Gutkind, Gabriel O.

    2014-01-01

    KPC-2-producing Klebsiella pneumoniae isolates mainly correspond to clonal complex 258 (CC258); however, we describe KPC-2-producing K. pneumoniae isolates belonging to invasive sequence type 23 (ST23). KPC-2 has scarcely been reported to occur in ST23, and this report describes the first isolation of this pathogen in the Americas. Acquisition of resistant markers in virulent clones could mark an evolutionary step toward the establishment of these clones as major nosocomial pathogens. PMID:25031447

  4. EST Table: DC551591 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DC551591 E_FL_phe-_25H04_F_0 11/12/09 n.h 10/09/28 53 %/258 aa ref|XP_001810169.1| ...a gnl|Amel|GB17667-PA 10/09/10 53 %/258 aa gi|189238626|ref|XP_001810169.1| PREDICTED: similar to CG12581 CG12581-PA [Tribolium castaneum] DC551591 phe- ...

  5. NCBI nr-aa BLAST: CBRC-CELE-05-0102 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CELE-05-0102 ref|NP_503686.1| Seven TM Receptor family member (str-258) [Caenor...habditis elegans] ref|NP_503659.2| Y19D10A.2 [Caenorhabditis elegans] gb|AAK68415.2|AC006722_7 Hypothetical protein Y19D10A.2 [Caeno...rhabditis elegans] gb|AAD14695.1| Seven tm receptor protein 258 [Caenorhabditis elegans] NP_503686.1 1e-164 83% ...

  6. Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts.

    Science.gov (United States)

    Chiu, Ching-Feng; Peng, Jei-Ming; Hung, Shao-Wen; Liang, Chi-Ming; Liang, Shu-Mei

    2012-07-28

    Recombinant capsid protein VP1 (rVP1) of foot-and-mouth disease virus inhibits invasion/metastasis of cancer cells. Here we studied its mechanism of action on human cervical cancer cells. The inhibition of cell invasion by rVP1 was accompanied with reduction in phosphatidylinositol (3,4,5)-triphosphate (PIP3), phospho-Akt S473, phosphorylated prohibitin (phospho-PHB) T258 in lipid rafts, dissociation of phospho-PHB T258 with Raf-1 and the inactivation of Raf-1/ERK. Addition of PIP3 or overexpression of constitutively active Akt and raft-anchored PHB T258 but not PHB T258I mutant protein reversed the inhibitory effects of rVP1. rVP1 inhibited cervical tumor growth and metastasis, and prolonged survival in xenograft mouse models. These results suggest that rVP1 inhibits cancer metastasis via de-phosphorylation of Akt and PHB T258 in lipid rafts to downregulate Raf/ERK signaling.

  7. Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance

    Science.gov (United States)

    Nordmann, Patrice; Poirel, Laurent

    2015-01-01

    The management of infections due to Klebsiella pneumoniae has been complicated by the emergence of antimicrobial resistance, especially to carbapenems. Resistance to carbapenems in K. pneumoniae involves multiple mechanisms, including the production of carbapenemases (e.g., KPC, NDM, VIM, OXA-48-like), as well as alterations in outer membrane permeability mediated by the loss of porins and the upregulation of efflux systems. The latter two mechanisms are often combined with high levels of other types of β-lactamases (e.g., AmpC). K. pneumoniae sequence type 258 (ST258) emerged during the early to mid-2000s as an important human pathogen and has spread extensively throughout the world. ST258 comprises two distinct lineages, namely, clades I and II, and it seems that ST258 is a hybrid clone that was created by a large recombination event between ST11 and ST442. Incompatibility group F plasmids with blaKPC have contributed significantly to the success of ST258. The optimal treatment of infections due to carbapenemase-producing K. pneumoniae remains unknown. Some newer agents show promise for treating infections due to KPC producers; however, effective options for the treatment of NDM producers remain elusive. PMID:26169401

  8. A thiostrepton resistance gene and its mutants serve as selectable markers in Geobacillus kaustophilus HTA426.

    Science.gov (United States)

    Wada, Keisuke; Kobayashi, Jyumpei; Furukawa, Megumi; Doi, Katsumi; Ohshiro, Takashi; Suzuki, Hirokazu

    2016-01-01

    Effective utilization of microbes often requires complex genetic modification using multiple antibiotic resistance markers. Because a few markers have been used in Geobacillus spp., the present study was designed to identify a new marker for these thermophiles. We explored antibiotic resistance genes functional in Geobacillus kaustophilus HTA426 and identified a thiostrepton resistance gene (tsr) effective at 50 °C. The tsr gene was further used to generate the mutant tsr(H258Y) functional at 55 °C. Higher functional temperature of the mutant was attributable to the increase in thermostability of the gene product because recombinant protein produced from tsr(H258Y) was more thermostable than that from tsr. In fact, the tsr(H258Y) gene served as a selectable marker for plasmid transformation of G. kaustophilus. This new marker could facilitate complex genetic modification of G. kaustophilus and potentially other Geobacillus spp.

  9. Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

    Science.gov (United States)

    Liu, Zhiguo; Yu, Shufang; Chen, Di; Shen, Guoliang; Wang, Yu; Hou, Leping; Lin, Dan; Zhang, Jinsan; Ye, Faqing

    2016-01-01

    FGFR1 is well known as a molecular target in anticancer drug design. TKI258 plays an important role in RTK inhibitors. Utilizing TKI258 as a lead compound that contains a quinazolinone nucleus, we synthesized four series of 3-vinyl-quinoxalin-2(1H)-one derivatives, a total of 27 compounds. We further evaluated these compounds for FGFR1 inhibition ability as well as cytotoxicity against four cancer cell lines (H460, B16-F10, Hela229, and Hct116) in vitro. Some compounds displayed good-to-excellent potency against the four tested cancer cell lines compared with TKI258. Structure–activity relationship analyses indicated that small substituents at the side chain of the 3-vinyl-quinoxalin-2(1H)-one were more effective than large substituents. Lastly, we used molecular docking to obtain further insight into the interactions between the compounds and FGFR1. PMID:27217720

  10. Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1.

    Science.gov (United States)

    Liu, Zhiguo; Yu, Shufang; Chen, Di; Shen, Guoliang; Wang, Yu; Hou, Leping; Lin, Dan; Zhang, Jinsan; Ye, Faqing

    2016-01-01

    FGFR1 is well known as a molecular target in anticancer drug design. TKI258 plays an important role in RTK inhibitors. Utilizing TKI258 as a lead compound that contains a quinazolinone nucleus, we synthesized four series of 3-vinyl-quinoxalin-2(1H)-one derivatives, a total of 27 compounds. We further evaluated these compounds for FGFR1 inhibition ability as well as cytotoxicity against four cancer cell lines (H460, B16-F10, Hela229, and Hct116) in vitro. Some compounds displayed good-to-excellent potency against the four tested cancer cell lines compared with TKI258. Structure-activity relationship analyses indicated that small substituents at the side chain of the 3-vinyl-quinoxalin-2(1H)-one were more effective than large substituents. Lastly, we used molecular docking to obtain further insight into the interactions between the compounds and FGFR1.

  11. Risk factors of late preterm birth and perinatal complications among late preterm infant%晚期早产的危险因素及围产期并发症分析

    Institute of Scientific and Technical Information of China (English)

    张莹; 赫英东; 陈倩

    2014-01-01

    To analyze maternal and neonatal complications among late preterm birth cases and to investigate risk factors of late preterm birth. Methods This was a retrospective analysis of 258 late preterm cases (late preterm group) born in Peking University First Hospital from January 1, 2009 to December 31, 2010. Maternal comorbidity and complications, delivery modes, and neonatal complications of these 258 late preterm infants were compared with 308 term cases (term group) during the same period. Statistical analysis was performed usingχ2 test, Fisher's exact probability test, t test and logistic regression. Results In Peking University First Hospital, late preterm births accounted for 3.9%(258/6 695) of live births and 60.1%(258/429) of preterm births. The incidence of the following maternal complications among the late preterm group was higher than that among term group(all P<0.05): severe pre-eclampsia [7.4%(19/258) vs 1.0%(3/308), χ2=15.35]; preterm rupture of membrane [42.6%(110/258) vs 15.3%(47/308), χ2=52.49];cervical insufficiency [1.9%(5/258) vs 0.0%(0/308), Fisher's exact test];placenta previa[3.5%(9/258) vs 0.6%(2/308), Fisher's exact test] and placental abruption [2.7%(7/258) vs 0.3%(1/308), Fisher's exact test]. Severe pre-eclampsia was the major risk factor leading to late preterm birth. The incidence of the following neonatal complications among the late preterm group was higher than that among term group (all P<0.05):respiratory distress syndrome (NRDS) [11.6%(30/258) vs 1.6%(5/308), χ2=24.22]; hyperbilirubinemia [64.3%(166/258) vs 39.6%(122/308),χ2=34.36];electrolyte disturbance [12.8%(33/258) vs 1.6(95/308),χ2=27.96];hypothermia [7.0%(18/258) vs 2.9%(9/308),χ2=5.08];infectious pneumonia[13.6%(35/258) vs 3.2%(10/308), χ2=20.43]; leukoencephalopathy [3.1%(8/258) vs 0.3%(1/308), χ2=5.25]; low body temperature [18.6%(48/258) vs 3.6%(11/308),χ2=33.98] and neonatal asphyxia [6.2%(16/258) vs 1.0%(3/308),χ2=11.86]. The incidence of the following

  12. Comparative Genomic Analysis of KPC-Encoding pKpQIL-Like Plasmids and Their Distribution in New Jersey and New York Hospitals

    Science.gov (United States)

    Chen, Liang; Chavda, Kalyan D.; Melano, Roberto G.; Jacobs, Michael R.; Koll, Brian; Hong, Tao; Rojtman, Albert D.; Levi, Michael H.; Bonomo, Robert A.

    2014-01-01

    The global spread of Klebsiella pneumoniae carbapenemase (KPC) is predominately associated with K. pneumoniae strains genotyped as sequence type 258 (ST258). The first ST258-associated plasmid, pKpQIL, was described in Israel in 2006, but its history in the northeastern United States remains unknown. Six pKpQIL-like plasmids from four K. pneumoniae isolates (three ST258 and one ST234), one Escherichia coli isolate, and one Enterobacter aerogenes isolate, collected from 2003 to 2010 in New York (NY) and New Jersey (NJ) hospitals, were completely sequenced. The sequences and overall sizes of the six plasmids are highly similar to those of pKpQIL; the major difference is that five of six NJ/NY strains harbor blaKPC-2, while pKpQIL contains blaKPC-3. Moreover, a 26.7-kb fragment was inverted in pKpQIL-234 (from ST234 K. pneumoniae), while a 14.5-kb region was deleted in pKpQIL-Ec (from ST131 E. coli). PCR screening of 284 other clinical K. pneumoniae isolates identified 101 (35.6%) harboring pKpQIL-like plasmids from 9 of 10 surveyed hospitals, demonstrating the wide dissemination of pKpQIL in this region of endemicity. Among the positive isolates, 87.1% were typed as ST258 and 88.1% carried blaKPC-2. The finding of pKpQIL-like plasmid in this study from strains that predate the initial report of KPC in Israel provides evidence that pKpQIL may have originated in the United States. Our findings demonstrate that pKpQIL plasmids are both spreading clonally in ST258 strains and spreading horizontally to different sequence types and species, further highlighting the clinical and public health concerns associated with carbapenem resistance. PMID:24614371

  13. Seroprevalence of Toxoplasma gondii in females alpacas of SAIS Pachacutec, Central Sierra of Peru

    OpenAIRE

    De La Cruz C., Hernán; Laboratorio de Microbiología y Parasitología Veterinaria, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima; Chávez V., Amanda; Laboratorio de Microbiología y Parasitología Veterinaria, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima.; Casas A., Eva; Laboratorio de Microbiología y Parasitología Veterinaria, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima-Perú.; Li E., Olga; Laboratorio de Patología Clínica y Biología Molecular, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú.

    2011-01-01

    The objective of this study was to determine the seroprevalence of antibodies against Toxoplasma gondii in alpacas at the production unit of Cuyo, part of SAIS Pachacutec in the Central Sierra of Peru. Blood samples were collected in 258 female alpacas in January 2003. Sera were tested against T. gondii antibodies by the Indirect Immunoflorescence test (IFI). The results showed that 8.5 ± 3.4% (22/258) of animals had antibodies against the parasite. This frequency is lower than in other alpac...

  14. Effect of urea and urea-gamma treatments on cellulose degradation of Thai rice straw and corn stalk

    Energy Technology Data Exchange (ETDEWEB)

    Banchorndhevakul, Siriwattana E-mail: siriwatt@ji-net.com

    2002-08-01

    Cellulose degradation of 20% urea treated and 20% urea-10 kGy gamma treated Thai rice straw and corn stalk showed that combination effect of urea and gamma radiation gave a higher % decrease in neutral detergent fiber (NDF), acid detergent fiber (ADF), acid detergent lignin (ADL), cellulose, hemicellulose, and lignin and cutin in comparison with urea effect only for both room temperature storage and room temperature +258 K storage. The results also indicated that cellulose degradation proceeded with time, even at 258 K. A drastic drop to less than half of the original contents in NDF, ADF, and ADL could not be obtained in this study.

  15. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the safety of “citicoline” as a Novel Food ingredient

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on citicoline as a novel food ingredient in the context of Regulation (EC) No 258/97. The novel food ingredient (NFI), citicoline, is chol......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on citicoline as a novel food ingredient in the context of Regulation (EC) No 258/97. The novel food ingredient (NFI), citicoline...

  16. Effect of urea and urea-gamma treatments on cellulose degradation of Thai rice straw and corn stalk

    Science.gov (United States)

    Banchorndhevakul, Siriwattana

    2002-08-01

    Cellulose degradation of 20% urea treated and 20% urea-10 kGy gamma treated Thai rice straw and corn stalk showed that combination effect of urea and gamma radiation gave a higher % decrease in neutral detergent fiber (NDF), acid detergent fiber (ADF), acid detergent lignin (ADL), cellulose, hemicellulose, and lignin and cutin in comparison with urea effect only for both room temperature storage and room temperature +258 K storage. The results also indicated that cellulose degradation proceeded with time, even at 258 K. A drastic drop to less than half of the original contents in NDF, ADF, and ADL could not be obtained in this study.

  17. Reconstruction of Chromotomographic Imaging System Infrared Hyperspectral Scenes

    Science.gov (United States)

    2005-03-21

    Projected area of a square pixel at 3258m entered in metres^2 converted to centimetres^2 A1 = 3.258^2 * 1000; D = .1; % diameter of the telescope in...Projected area of a square pixel at 3258m entered in metres^2 converted to centimetres^2 A1 = 3.258^2 * 1000; D = .1; % diameter of the telescope in...exp(h*c./(lamda_base(count)*1e-6*kB.*truth)) - 1)) * int/sub_lamda; end rad_p(index,:,:) = temporary; end %Projected area of a square pixel at 3258m

  18. IRIG Serial Time Code Formats

    Science.gov (United States)

    2016-08-01

    by Secretariat Range Commanders Council U.S. Army White Sands Missile Range, New Mexico 88002-5110 This page intentionally left blank. IRIG...New Mexico 88002-5110 Phone: DSN 258-1107 Com (575) 678-1107 Fax: DSN 258-7519 Com (575) 678-7519 Email: usarmy.wsmr.atec.list.rcc@mail.mil...and G. It should be noted that this standard reflects the present state of the art in serial time code formatting and is not intended to constrain

  19. Epithelial mesenchymal transition status is associated with anti-cancer responses towards receptor tyrosine-kinase inhibition by dovitinib in human bladder cancer cells.

    Science.gov (United States)

    Hänze, Jörg; Henrici, Marcus; Hegele, Axel; Hofmann, Rainer; Olbert, Peter J

    2013-12-11

    Dovitinib (TKI-258) is a receptor tyrosine kinase (RTK) inhibitor targeting fibroblast growth factor receptor (FGFR) and further related RTKs. TKI-258 is under investigation as anticancer drug for the treatment of various cancers including bladder cancer with aberrant RTK signaling. Here, we analyzed the responses of ten human bladder cancer cell lines towards TKI-258 treatment in relation to the epithelial mesenchymal transition (EMT) status of the cells. Expression of epithelial marker E-cadherin as well as mesenchymal markers N-cadherin and vimentin was determined by quantitative RT-PCR and Western-blot in RNA and protein extracts from the cultured cell lines. The cell responses were analyzed upon addition of TKI-258 by viability/proliferation (XTT assay) and colony formation assay for measurement of cell contact independent growth. The investigated bladder cancer cell lines turned out to display quite different EMT patterns as indicated by the abundance of E-cadherin or N-cadherin and vimentin. Protein and mRNA levels of the respective components strongly correlated. Based on E-cadherin and N-cadherin mRNA levels that were expressed approximately mutual exclusively, an EMT-score was calculated for each cell line. A high EMT-score indicated mesenchymal-like cells and a low EMT-score epithelial-like cells. Then, we determined the IC₅₀ values for TKI-258 by dose response curves (0-12 μM TKI-258) in XTT assays for each cell line. Also, we measured the clonogenic survival fraction after adding TKI-258 (1 μM) by colony formation assay. We observed significant correlations between EMT-score and IC₅₀ values (r = 0.637, p = 0.0474) and between EMT-score and clonogenic survival fraction (r = 0.635, p = 0.0483) as analyzed by linear regression analyses. In sum, we demonstrated that the EMT status based on E-cadherin and N-cadherin mRNA levels may be useful to predict responses towards TKI-258 treatment in bladder cancer.

  20. Mapping of the nuclear fertility restorer gene for HL cytoplasmic male sterility in rice using microsatellite markers

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Bulked segregant analysis (BSA) of a BC1 population derived from Congguang 41A//Miyang 23/Congguang 41B was used to map the nuclear fertility restorer gene for Honglian (HL) cytoplasmic male sterility.One hundred and fifty-nine microsatellite primer pairs were screened for polymorphisms between the parents and between two bulks representing fertile and sterile plants.One microsatellite marker RM258 produced polymorphic products.The nuclear fertility restorer gene for HL cytoplasmic male sterility was mapped on chromosome 10,7.8cM from RM258.The restorer gene may be clustered on chromosome.

  1. Sintese, estudos estruturais e reatividade de naftoquinoniminas estaveis

    OpenAIRE

    Luiz Antonio Mazzini Fontoura

    1989-01-01

    Novas naftoquinoniminas estáveis foram sintetizadas por amonólise de naftoquinonas 2,5,8-trissubstituí das. Derivados dos novos compostos foram obtidos por reações de metilação. acetilação. condensação com cetonas e cicloadição com ciclopentadieno. Um estudo de tautomeria quinonimina-quinona através da técnica de UV-visível foi também realizado. New stable naphthoquinonimines were synthesised by ammonolysis of 2.5.8-trisubstituted naphthoquinones. Derivatives of the new compounds were obta...

  2. Sugar and Reducing Sugar Content Changes of Frost Sugarcane in Yunnan Area%云南蔗区3个主栽品种霜冻后的糖分变化

    Institute of Scientific and Technical Information of China (English)

    李复琴; 何文志; 杨洪昌; 张跃彬

    2014-01-01

    The variation of sucrose and reducing contents from suffering frost damage sugarcane of ROC 22, MT 69-421 and YZ 03-258 was analyzed in field of Yunnan Mile in 2013. The results indicated that the sucrose content of MT 69-421 was the highest in the period of 40 days after mild frost. The reducing sugar content of ROC 22 was the highest, followed by YZ 03-258 and MT 69-421. The sucrose of MT 69-421 was decreased faster than that of YZ 03-258 after frost damage, while the reducing sugar content of YZ 03-258 was increased faster than that of MT 69-421. Moreover, the sucrose content of ROC 22 was increasing and its reducing sugar content was decreasing during the experimental period.%对2013年云南省弥勒市朋普蔗区3个主栽品种ROC22、闽糖69-421和云蔗03-258在霜冻轻度冻伤后的糖分变化进行了检测分析。结果表明,经霜冻轻度冻伤40d内,闽糖69-421的蔗糖分最高,云蔗03-258的最低;闽糖69-421还原糖分最低,ROC22最高。闽糖69-421在霜冻后糖分下降较云蔗03-258快,云蔗03-258还原糖增加较闽糖69-421快,ROC22的糖分则继续增加,还原糖也继续下降。本研究结果可为霜冻对不同甘蔗品种的影响研究提供新的数据,同时为甘蔗生产管理提供参考依据。

  3. KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel.

    Science.gov (United States)

    Baraniak, A; Izdebski, R; Fiett, J; Herda, M; Derde, L P G; Bonten, M J M; Adler, A; Carmeli, Y; Goossens, H; Hryniewicz, W; Brun-Buisson, C; Gniadkowski, M

    2015-12-28

    In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.

  4. Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals

    Science.gov (United States)

    Wright, Meredith S.; Perez, Federico; Brinkac, Lauren; Jacobs, Michael R.; Kaye, Keith; Cober, Eric; van Duin, David; Marshall, Steven H.; Hujer, Andrea M.; Rudin, Susan D.; Hujer, Kristine M.

    2014-01-01

    Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the blaKPC genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The blaKPC gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time. PMID:24913165

  5. Gastrointestinal helminths in migratory Camel

    Directory of Open Access Journals (Sweden)

    S G Rewatkar

    Full Text Available Survey of gastrointestinal helminth parasites in camel migrated from U.P., M.P., and Rajasthan at Nagpur region was carried out in early summer, 2008. Total 28 samples (12 males and 16 females were collected from different places of Nagpur region. They revealed parasites as Trichuris sp.(50%, Strongyloides sp.(32.14%, Trichostrongylus sp.(10.71%, Nematodirus sp.(10.71%, Haemonchus sp.(14.28%, Eurytrema sp.(21.42% ,Eimeria sp.(25%, Entamoeba sp.(17.85% and Balantidium sp.(7.14%.All were found positive for mixed helminthic infection. [Vet World 2009; 2(7.000: 258-258

  6. New insight into the molecular mechanisms of the biological effects of DNA minor groove binders.

    Directory of Open Access Journals (Sweden)

    Xinbo Zhang

    Full Text Available BACKGROUND: Bisbenzimides, or Hoechst 33258 (H258, and its derivative Hoechst 33342 (H342 are archetypal molecules for designing minor groove binders, and widely used as tools for staining DNA and analyzing side population cells. They are supravital DNA minor groove binders with AT selectivity. H342 and H258 share similar biological effects based on the similarity of their chemical structures, but also have their unique biological effects. For example, H342, but not H258, is a potent apoptotic inducer and both H342 and H258 can induce transgene overexpression in in vitro studies. However, the molecular mechanisms by which Hoechst dyes induce apoptosis and enhance transgene overexpression are unclear. METHODOLOGY/PRINCIPAL FINDINGS: To determine the molecular mechanisms underlying different biological effects between H342 and H258, microarray technique coupled with bioinformatics analyses and multiple other techniques has been utilized to detect differential global gene expression profiles, Hoechst dye-specific gene expression signatures, and changes in cell morphology and levels of apoptosis-associated proteins in malignant mesothelioma cells. H342-induced apoptosis occurs in a dose-dependent fashion and is associated with morphological changes, caspase-3 activation, cytochrome c mitochondrial translocation, and cleavage of apoptosis-associated proteins. The antagonistic effect of H258 on H342-induced apoptosis indicates a pharmacokinetic basis for the two dyes' different biological effects. Differential global gene expression profiles induced by H258 and H342 are accompanied by unique gene expression signatures determined by DNA microarray and bioinformatics software, indicating a genetic basis for their different biological effects. CONCLUSIONS/SIGNIFICANCE: A unique gene expression signature associated with H342-induced apoptosis provides a new avenue to predict and classify the therapeutic class of minor groove binders in the drug

  7. 77 FR 20059 - License Amendment To Increase the Maximum Reactor Power Level, Florida Power & Light Company...

    Science.gov (United States)

    2012-04-03

    ... supply. The FAS underlies approximately 100,000 square miles (258,000 km\\2\\) in southern Alabama..., crustaceans, fish, sea turtles, and marine mammals. The portion of Biscayne Bay adjacent to Turkey Point is... smallii tiny polygala E Insects Heraclides aristodemus schaus swallowtail E ponceanus. butterfly....

  8. 76 FR 71379 - Florida Power & Light Company, Turkey Point, Units 3 and 4; Draft Environmental Assessment and...

    Science.gov (United States)

    2011-11-17

    ... supply. The FAS underlies approximately 100,000 square miles (258,000 km\\2\\) in southern Alabama..., mollusks, crustaceans, fish, sea turtles, and marine mammals. The portion of Biscayne Bay adjacent to... swallowtail E ponceanus. butterfly. Mammals Puma concolor mountain lion \\b\\... T/SA Felis concolor...

  9. Predicting the Influence of Social Resources on African American Wife and Daughter Caregivers' Depressive Symptoms

    Science.gov (United States)

    Rozario, Philip A.; Chadiha, Letha A.; Proctor, Enola K.; Morrow-Howell, Nancy

    2008-01-01

    This study--on 100 African American wife and 258 daughter primary caregivers--uses a contextual approach in its examination of the relationship between social resources and caregiver depressive symptoms. At the bivariate level, significant differences in certain key characteristics of primary caregivers and care receivers underscore the…

  10. Cost Effectiveness Analysis, A DTIC Bibliography.

    Science.gov (United States)

    1980-07-01

    Model for Estimating * 0 6 DUGAS. DORIS J. Software Life Cycle Costs (ModelGuidelines for Attracting Private *4Concept). Volume 1.Capital to Corp$ of...of Category It Test Program A0-A023 442 An Econometric Analysis of aitonance Data. VOlunteer Enlistments of service AD-AO21 258 HUMPHREYS . THOMAS H

  11. Intervención social y el debate sobre lo público

    Directory of Open Access Journals (Sweden)

    Maria del Pilar Acosta

    2015-08-01

    Full Text Available Reseña del libro:Grupo de Intervención y Responsabilidad Social (2014. Intervención social y el debate sobre lo público: reflexiones conceptuales y casos locales. Colección "El Sur es Cielo Roto", No. 9. Cali, Colombia: Universidad Icesi, Facultad de Derecho y Ciencias Sociales. 258 pp.

  12. Intervención social y el debate sobre lo público

    OpenAIRE

    Maria del Pilar Acosta

    2015-01-01

    Reseña del libro:Grupo de Intervención y Responsabilidad Social (2014). Intervención social y el debate sobre lo público: reflexiones conceptuales y casos locales. Colección "El Sur es Cielo Roto", No. 9. Cali, Colombia: Universidad Icesi, Facultad de Derecho y Ciencias Sociales. 258 pp.

  13. How Do European Pharmacy Students Rank Competences for Practice?

    NARCIS (Netherlands)

    Atkinson, Jeffrey; De Paepe, Kristien; Sánchez Pozo, Antonio; Rekkas, Dimitrios; Volmer, Daisy; Hirvonen, Jouni; Bozic, Borut; Skowron, Agnieska; Mircioiu, Constantin; Marcincal, Annie; Koster, Andries; Wilson, Keith; van Schravendijk, Chris; Hočevar, Sandra

    2016-01-01

    European students (n = 370), academics (n = 241) and community pharmacists (n = 258) ranked 13 clusters of 68 personal and patient care competences for pharmacy practice. The results show that ranking profiles for all three groups as a rule were similar. This was especially true of the comparison

  14. What is a Pharmacist: Opinions of Pharmacy Department Academics and Community Pharmacists on Competences Required for Pharmacy Practice

    NARCIS (Netherlands)

    Atkinson, Jeffrey; de Paepe, Kristien; Sánchez Pozo, Antonio; Rekkas, Dimitrios; Volmer, Daisy; Hirvonen, Jouni; Bozic, Borut; Skowron, Agnieska; Mircioiu, Constantin; Marcincal, Annie; Koster, Andries; Wilson, Keith; van Schravendijk, Chris; Wilkinson, Jamie

    2016-01-01

    This paper looks at the opinions of 241 European academics (who provide pharmacy education), and of 258 European community pharmacists (who apply it), on competences for pharmacy practice. A proposal for competences was generated by a panel of experts using Delphi methodology. Once finalized, the

  15. 77 FR 66850 - Public Workshop on Burkholderia: Exploring Current Issues and Identifying Regulatory Science Gaps

    Science.gov (United States)

    2012-11-07

    ... Research Microbiologist,'' The New England Journal of Medicine, vol. 345(4), pp. 256-258, 2001. 7. Gregory...), pp. 1113-1117, 2010. 3. Wiersinga W.J., B.J. Currie, and S.J. Peacock, ``Melioidosis,'' The New England Journal of Medicine, vol. 367(11), pp. 1035-1044, 2012. 4. Limmathurotsakul D., W. Chaowagul, W...

  16. Hot or Not: An Analysis of Online Professor-Shopping Behavior of Business Students

    Science.gov (United States)

    Hossain, Tarique M.

    2010-01-01

    With the proliferation of Web sites that allow students to praise or disparage their instructors depending on their whims, instructors across the country essentially are becoming subjects of comparison shopping by prospective students. Using a sample survey of 258 students majoring in business at a public university on the west coast of the United…

  17. Symposium on Engineering With Nuclear Explosives January 14-16, 1970, Las Vegas, Nevada. Volume 1

    Science.gov (United States)

    1970-05-01

    Sci. 260, 721 (1962). 27. R. Rossin, J. Bersan and G. Urbain , Compt. Rend. Acad. Sci. Paris 258, 562 (1964). 28. S. P. Clarke, Jr., ed., Handbook of... agricultural consumption. Reported flow rates are generally a few feet per day or less, so one would expect any hazard to be limited to within about 20 km of the

  18. Immunomodulation by probiotics: efficacy and safety evaluation

    NARCIS (Netherlands)

    Ezendam J; Opperhuizen A; Loveren H van; TOX

    2005-01-01

    Probiotics are non-pathogenic bacteria that are used as functional food components with claimed health-promoting effects. In the European Union probiotics are regulated via the Novel Foods Regulation (258/97/EC). This regulation is only applied to strains that were not used before 1997 and concerns

  19. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread

    NARCIS (Netherlands)

    Weterings, V; Zhou, K; Rossen, J W; van Stenis, D; Thewessen, E; Kluytmans, J; Veenemans, J

    2015-01-01

    We describe an outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-KP) ST258 that occurred in two institutions (a hospital and a nursing home) in the Netherlands between July and December 2013. In total, six patients were found to be positive for KPC-KP. All is

  20. 75 FR 63431 - Radio Broadcasting Services; Willow Creek, CA

    Science.gov (United States)

    2010-10-15

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Willow Creek, CA AGENCY: Federal Communications... allotment of FM Channel 258A at Willow Creek, California. Petitioner, the auction winner and permittee of Channel 253A, Willow Creek, has submitted an application to specify operation of the station on...

  1. A Study of Novice Systems Analysis Problem Solving Behaviors Using Protocol Analysis

    Science.gov (United States)

    1992-09-01

    34Skill in Working Memory". In G. Bower (Ed), The Psychology of Learning and Motivation, v.16, pp. 2-58, Academic Press, 1982. Chi, Michelene T.H...Chase, W.G., and Ericsson, K.A., "Skill in Working Memory". In G. Bower (Ed), The Psychology of Learning and Motivation, v.16, Academic Press, 1982

  2. Data of evolutionary structure change: 1AVMB-1COJA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AVMB-1COJA 1AVM 1COJ B A -AVYTLPELPYDYSALEPYISGEIMELHHDKHHKAYVDG...>GLU CA 207 ALA CA 258 1AVM... B 1AVMB PKGSAPERPTDE ...n> 1AVM B 1AVMB ILE CA 499 LEU CA 507 GLY CA 452

  3. Enhancing Air Base Defense Through Joint Doctrine

    Science.gov (United States)

    2009-01-01

    Warfare, 258. 40 Tse-Tung, Mao Tse-Tung on Guerrilla Warfare, 27. 41 Maj David P. Briar , USAF, Sharpening the Eagle’s Talons: Assessing Air Base Defense...and Contingency Operations Doctrine 1942-1976, Washington, D.C.: Center ofMilitary History U.S. Army, 2006 (143) Briar , Maj David P., USAF, Sharpening

  4. Beyond the Resignation Debate: A New Framework for Civil-Military Dialogue

    Science.gov (United States)

    2015-01-01

    recent years. For example, Risa A. Brooks, associate professor of political science at Marquette Uni- versity, considers the potential costs and...Leadership in Wartime (New York: Free Press, 2002), 258–64; Feaver, Armed Servants, 68–75; and Risa A. Brooks, “Militaries and Political Activity in

  5. Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013.

    Science.gov (United States)

    Tseng, I-Ling; Liu, Yu-Mei; Wang, Shiow-Jen; Yeh, Hung-Yi; Hsieh, Chia-Lun; Lu, Hsueh-Lin; Tseng, Yu-Chuan; Mu, Jung-Jung

    2015-01-01

    The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for detection of the carbapenemase genes, assessment of antimicrobial susceptibility and molecular epidemiology studies. Of these 994 isolates, 183 (18.4%) had carbapenemase genes: 157 (15.8%) KPC (145 KPC-2 and 12 KPC-17), 16 (1.6%) IMP-8, 9 (0.9%) VIM-1, and 1 (0.1%) NDM-1. KPC had the highest prevalence rate among the carbapenemases and represented a major epidemic clone circulating in Taiwan. The ST512 and ST258 KPC-2 KPs were first identified in Taiwan and were grouped into a small cluster in the PFGE profile. In addition, the genetic structure encompassing the blaKPC gene of the ST512 and ST258 isolates showed a different pattern from that of other KPC isolates. ST11 may be a major sequence type circulating in Taiwan, although a specific minor clone has begun to be observed. This is the first report of ST258 and ST512 KPC-2 KP isolates in Taiwan, whether ST258 and ST512 will become the next endemic problems in Taiwan should be closely monitored.

  6. Data of evolutionary structure change: 1TT5B-3DBHB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1TT5B-3DBHB 1TT5 3DBH B B MKLDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLD...CA 209 VAL CA 310 LEU CA 304 3DBH B 3DBHB QNIQF...>LEU CA 232 TYR CA 258 LEU CA 237 3DBH... B 3DBHB ITATLEGKNRTLYL <

  7. DMPD: Modulation of Toll-interleukin 1 receptor mediated signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15662540 Modulation of Toll-interleukin 1 receptor mediated signaling. Li X, Qin J....iated signaling. PubmedID 15662540 Title Modulation of Toll-interleukin 1 receptor media... J Mol Med. 2005 Apr;83(4):258-66. Epub 2005 Jan 21. (.png) (.svg) (.html) (.csml) Show Modulation of Toll-interleukin 1 receptor med

  8. Developing Attitude Scale, Reliability and Validity for Pre-Service Teachers towards Drama Lesson

    Science.gov (United States)

    Çelik, Özkan; Bozdemir, Hafife; Uyanik, Gökhan

    2016-01-01

    The purpose of this study is to develop an attitude scale for pre-service teachers towards drama lesson. Survey model was used in study. The sample of study consisted of 258 pre-service teachers. "Attitude scale towards drama lesson for pre-service teachers" was developed and used as data collection tool. Exploratory and confirmatory…

  9. Fostering Healthy Lifestyles in the African American Population

    Science.gov (United States)

    Murimi, Mary; Chrisman, Matthew S.; McAllister, Tiffany; McDonald, Olevia D.

    2015-01-01

    Approximately 8.3% of the U.S. population (25.8 million people) is affected by type 2 diabetes. The burden of diabetes is disproportionately greater in the African American community. Compared with non-Hispanic Caucasian adults, the risk of diagnosed type 2 diabetes was 77% higher among non-Hispanic Blacks, who are 27% more likely to die of…

  10. Assessing the Desired and Actual Levels of Teachers' Participation in Decision-Making in Secondary Schools of Ethiopia

    Science.gov (United States)

    Bademo, Yismaw; Tefera, Bekalu Ferede

    2016-01-01

    This study was conducted to assess the desired and actual levels of teachers' participation in decision-making process in Ethiopian secondary schools. For this, the study employed a cross-sectional survey design collecting data from sampled secondary school teachers (n = 258) found in Assosa Zone, Benishangual Gumuz Regional state, Ethiopia.…

  11. Data of evolutionary structure change: 1CEVF-2RLAA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CEVF-2RLAA 1CEV 2RLA F A MKPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERL...CA 242 TYR CA 258 SER CA 285 PRO CA 333 2RLA... A 2RLAA KFPDVPGF...LY CA 377 VAL CA 481 HIS CA 566 LEU CA 572 2RLA A 2RLAA LLGRK

  12. 76 FR 40154 - Unified Agenda of Federal Regulatory and Deregulatory Actions-Spring 2011

    Science.gov (United States)

    2011-07-07

    ....small@fcc.gov . RIN: 3060-AH65 344. Exposure to Radiofrequency Electromagnetic Fields Legal Authority... Wireless 3060-AH65 Services (ET Docket No. 00-258). 344 Exposure to 3060-AI17 Radiofrequency Electromagnetic Fields. 345 Unlicensed Operation in 3060-AI52 the TV Broadcast Bands (ET Docket No. 04-186)....

  13. 75 FR 21903

    Science.gov (United States)

    2010-04-26

    ... Docket No. 00-258) 3060-AH65 315 Exposure to Radiofrequency Electromagnetic Fields 3060-AI17 316.... EXPOSURE TO RADIOFREQUENCY ELECTROMAGNETIC FIELDS Legal Authority: 47 USC 151; 47 USC 302 and 303; 47 USC... rules relating to compliance of transmitters and facilities with guidelines for human exposure to...

  14. 78 FR 44359 - Unified Agenda of Federal Regulatory and Deregulatory Actions-Spring 2013

    Science.gov (United States)

    2013-07-23

    ... Identifier No. 317 New Advanced Wireless 3060-AH65 Services (ET Docket No. 00-258). 318 Exposure to Radiofrequency 3060-AI17 Electromagnetic Fields. 319 Unlicensed Operation in 3060-AI52 the TV Broadcast Bands (ET... Radiofrequency Electromagnetic Fields Legal Authority: 47 U.S.C. 151; 47 U.S.C. 302 and 303; 47 U.S.C. 309(j);...

  15. JUNE ISSUE 2008 FINAL.cdr

    African Journals Online (AJOL)

    Only 20.2% were accessible for diagnosis by ultrasound scanning, while. 25.8% of them were ... Nigeria even more than a decade after the safe. 1 motherhood .... previous abortion and maternal age over 35 years . In 77.4% of patients in this ...

  16. 78 FR 41424 - Audits of States, Local Governments, and Non-Profit Organizations; OMB Circular A-133 Compliance...

    Science.gov (United States)

    2013-07-10

    ... BUDGET Audits of States, Local Governments, and Non-Profit Organizations; OMB Circular A-133 Compliance... Facilities Formula Grants (as part of the Federal Transit Cluster) The deleted programs are: CFDA 14.258--Tax.... Appendix VII provides an audit alert concerning deletion of American Recovery and Reinvestment Act...

  17. The Motivational Determinants of Students at Risk of Having Reading Difficulties: Planned Behavior Theory and Goal Importance.

    Science.gov (United States)

    Sideridis, Georgios D.; Padeliadu, Susana

    2001-01-01

    This study compared the motivational determinants of 258 low and high elementary grade readers in Greece within the framework of planned behavior theory. Low performing readers exhibited significantly lower perceptions of goal importance, intention to achieve, belief strength, outcome evaluation, and normative beliefs. The planned behavior model…

  18. The practice of exclusive breastfeeding among mothers attending a ...

    African Journals Online (AJOL)

    2012-08-08

    Aug 8, 2012 ... the World Health Organization (WHO) revised its infant. Abstract ... exclusively and had received infant feeding counselling (n = 258 vs. n = 65, p-value < 0.05). Exposure to infant ... by the health services to HIV-positive mothers.2 Exclusive ... qualitative study, Doherty et al identified key barriers faced by.

  19. The Effect of Microbial FE(III) Reduction on Smectite Flocculation

    Science.gov (United States)

    2005-01-01

    2.58 g of Nanoplast -embedded and microtome-sliced smectite sterilized clay were prepared using a chemical balance, samples were prepared for TEM...play an important role in promoting fundamentally affects the physicochemical properties of clay flocculation. The hydrophilic Nanoplast resin

  20. The Pax gene family: Highlights from cephalopods

    Science.gov (United States)

    Baratte, Sébastien; Andouche, Aude; Bonnaud-Ponticelli, Laure

    2017-01-01

    Pax genes play important roles in Metazoan development. Their evolution has been extensively studied but Lophotrochozoa are usually omitted. We addressed the question of Pax paralog diversity in Lophotrochozoa by a thorough review of available databases. The existence of six Pax families (Pax1/9, Pax2/5/8, Pax3/7, Pax4/6, Paxβ, PoxNeuro) was confirmed and the lophotrochozoan Paxβ subfamily was further characterized. Contrary to the pattern reported in chordates, the Pax2/5/8 family is devoid of homeodomain in Lophotrochozoa. Expression patterns of the three main pax classes (pax2/5/8, pax3/7, pax4/6) during Sepia officinalis development showed that Pax roles taken as ancestral and common in metazoans are modified in S. officinalis, most likely due to either the morphological specificities of cephalopods or to their direct development. Some expected expression patterns were missing (e.g. pax6 in the developing retina), and some expressions in unexpected tissues have been found (e.g. pax2/5/8 in dermal tissue and in gills). This study underlines the diversity and functional plasticity of Pax genes and illustrates the difficulty of using probable gene homology as strict indicator of homology between biological structures. PMID:28253300

  1. Parent-Child Cultural Orientations and Child Adjustment in Chinese American Immigrant Families

    Science.gov (United States)

    Chen, Stephen H.; Hua, Michelle; Zhou, Qing; Tao, Annie; Lee, Erica H.; Ly, Jennifer; Main, Alexandra

    2014-01-01

    Direct and indirect/mediated relations of (a) children's and parents' cultural orientations and (b) parent-child gaps in cultural orientations to children's psychological adjustment were examined in a socioeconomically diverse sample of 258 Chinese American children (age = 6-9 years) from immigrant families. Parents reported on children's and…

  2. Role of MTHFR A1298C gene polymorphism in the etiology of ...

    African Journals Online (AJOL)

    Upendra Yadav

    2015-07-17

    Jul 17, 2015 ... Marchal et al. (2008). 98. 108. 62. 79. 17. 22. 258. 295. 96. 123. 0.19. Stevens et al. (2008) ..... 1998;19: · 2129–32. [14] Esteller M, Garcia A, Martinez-Palones JM, Xercavins J, ... Watson A, Seers V, Bennett FI, et al. Complex ...

  3. AcEST: DK944926 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ngomona... 54 3e-07 sp|Q11M18|FOLD_MESSB Bifunctional protein folD OS=Mesorhizobium ... 54 6e-07 sp|A9IQD2|F...SRHGL 298 EA VA I+ TIA+LL+NT++AA R G+ Sbjct: 258 AEAAAVAGAITPVPGGVGPMTIAVLLRNTLVAAHRRAGV 296 >sp|Q11M18|FOLD_MESSB

  4. Dicty_cDB: Contig-U06991-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rio genomic clone DKEY-258H6, genomic sur... 42 9.8 1 ( ES512980 ) BIG_AF_20798 Brine Shrimp embryos, 10 hou...rs after... 42 9.8 1 ( ES508121 ) BIG_AF_15938 Brine Shrimp embryos, 10 hours after... 42 9.8 1 ( DW204133 )

  5. A Chronotopic Approach to Genre Analysis: An Exploratory Study

    Science.gov (United States)

    Crossley, Scott

    2007-01-01

    This paper will examine Bakhtin's theory that a genre's unity is defined by its chronotope [Bakhtin, M. M. (1981). Forms of time and of the chronotope in the novel. In M. Holquist (Ed.), "The dialogic imagination: Four essays" (pp. 84-258). Austin: University of Texas Press] and assume that, if this is true, the rhetorical unity within a specific…

  6. Fission life-time calculation using a complex absorbing potential

    CERN Document Server

    Scamps, Guillaume

    2015-01-01

    A comparison between the semi-classical approximation and the full quantum calculation with a complex absorbing potential is made with a model of the fission of 258Fm. The potential barrier is obtained with the constrained Skyrme HF+BCS theory. The life-time obtained by the two calculations agree with each other the difference being only by 25%.

  7. 78 FR 16705 - Llano Seco Riparian Sanctuary Unit Restoration and Pumping Plant/Fish Screen Facility Protection...

    Science.gov (United States)

    2013-03-18

    ... Street, Orland, CA 95963. Chico Branch Library, 1108 Sherman Avenue, Chico, CA 95926. CDFW Office, 629 Entler Ave, Suite 12, Chico, CA 95928. PCGID-PID Office, 258 South Butte Street, Willows, CA 95988... PCGID-PID consolidated three pumping plants into one new facility equipped with state-of-the-art fish...

  8. An evaluation of major placer minerals along the Valinokkam - Tuticorin coast, southern Tamil Nadu, India

    Digital Repository Service at National Institute of Oceanography (India)

    Cherian, A.; Chandrasekar, N.; Rajamanickam, G.V.; Gujar, A.R.

    from 2.58 to 41.78%, ilmenite weight percentage ranges from 3.15 to 46.49. In the case of zircon, weight percentage increases from 0.42 to 9.09% and that of magnetite accounts 2.91% of the total heavy minerals along the study area. The present study...

  9. Non-Intrusive Media Forensics Framework

    Science.gov (United States)

    2012-03-01

    quality digital cameras and audio recording devices coupled with the rise of the Internet as a means of information delivery has cause digital content... steganography ,” IEEE Trans. on Information Forensics and Security, vol. 3, no. 2, pp. 247–258, June 2008. [18] H. Farid, “Digital image ballistics from JPEG

  10. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the safety of “ r apeseed protein isolate ” as a Novel Food ingredient

    DEFF Research Database (Denmark)

    Tetens, Inge; Poulsen, Morten

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the safety of a “rapeseed protein isolate” (Isolexx™) as a novel food ingredient (NF) in the context of Regulation (EC) No 258/97. The NF...

  11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on bovine lactoferrin

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to carry out the additional assessment for ‘lactoferrin’ as a food ingredient in the context of Regulation (EC) No 258/97 taking into account the comments and objections...

  12. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on Dihydrocapsiate

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the safety of a synthetic dihydrocapsiate (DHC) as a food ingredient in the context of Regulation (EC) No 258/97 taking into account...

  13. Effect of the Ionosphere on Space and Terrestrial Systems

    Science.gov (United States)

    1978-01-01

    man- made noise. Further details concerning man- made noise and its variation can be obtained from CCIR Report 258 (1976), Spaulding and Disney (1974...Reflection Height M-ight of 250 km and 350 kmn ___ TABLE 1 4. LATERAL DEVIATION OF RAY PATH OFF THE Z S" CIRCLE PLANE FOR AN IONOPHERIC TILT 3 TANGLE OF

  14. AcEST: BP919050 [AcEST

    Lifescience Database Archive (English)

    Full Text Available in-like arabinogalactan protein 15 ... 31 4.5 sp|Q2TJA6|NKD1_DANRE Protein naked cuticle homolog 1 OS=Danio ...uery: 236 YVHISYH 216 ++H H Sbjct: 252 FIHTLLH 258 >sp|Q2TJA6|NKD1_DANRE Protein naked

  15. An Observational Study of a Prefrontal Convective Rainband Using Tamex Single-and Dual-Doppler Data

    Science.gov (United States)

    1991-01-01

    integration from the surface. Other Doppler studies, e.g., Chong and Testud (1983), Lin et al. 37 (1986), etc, also showed similiar results. 4.3 Variational...Atmos. Sci., 39, 258- 279. Chong, M., and J. Testud , 1983: Three-Dimensional Wind Field Analysis from Dual-Doppler Radar Data. Part III: The Boundary

  16. Occurrence of Pospiviroid in potato, tomato and some ornamental ...

    African Journals Online (AJOL)

    USER

    2010-05-03

    May 3, 2010 ... potato samples, 258 tomato leaves and 461 ornamental plants) were tested by reverse ... could be applied to the large-scale and multiple detection of plant ... 0.013 M disodium ethylenediaminetetraacetatet (EDTA) pH 7.0, 4M.

  17. File list: ALL.Bld.50.AllAg.B-Lymphocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Bld.50.AllAg.B-Lymphocytes hg19 All antigens Blood B-Lymphocytes SRX110938,SRX2...58,SRX730790,SRX730776,SRX730792,SRX730845,SRX271845,SRX1322299,SRX730805,SRX189387 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Bld.50.AllAg.B-Lymphocytes.bed ...

  18. The Prevalence of Positive Fungal Cultures in Patients with Chronic Rhinosinusitis in a High Altitude Region of Iran

    Directory of Open Access Journals (Sweden)

    Farnaz Hashemian

    2012-01-01

    Our data show that 25.8% of patients tested positive for the presence of fungi. The results strengthen the theory regarding the role of fungi in the pathogenesis of CRS even in areas with low humidity. Aspergillus was the most commonly isolated fungus.

  19. 76 FR 34892 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Snapper-Grouper Fishery of the...

    Science.gov (United States)

    2011-06-15

    ... classes of spawning fish resulting in a spawning potential ratio equal to 25.8 percent. The Council did... limit at 5-fish per person per day. This bag limit is projected to slow the rate of recreational harvest... management measure that would have implemented split season quotas for commercial black sea bass because...

  20. Cultural Consumption Patterns in South Africa: An Investigation of the Theory of Cultural Omnivores

    Science.gov (United States)

    Snowball, J. D.; Jamal, M.; Willis, K. G.

    2010-01-01

    Contrary to Bourdieu's theory ("Distinction: A social critique of the judgment of taste". Cambridge, Massachusetts: Harvard University Press (1984)) that cultural consumption of so-called "high" versus popular culture is determined by socio-economic class, Peterson ("Poetics" 21:243-258, 1992; "Poetics"…

  1. State of the Market

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Foreign Trade In the first three months, the volume of China's foreign trade reached $371.3 billion, growing 25.8 percent compared with the same period of last year, according to statistics released by the General Administration of Customs (see graph 1). The trade surplus stood at $23.3 billion at the end of March.

  2. Bilingual Environment and Bilingual Development of Korean-Chinese Children in Yanji, China

    Science.gov (United States)

    Choi, Hyewon Park; Won, Young Mee; Lee, Kwee-Ock

    2004-01-01

    The purpose of this study was to explore the extent of children's access to media and the relation between the use of media and language development, including its determinants, among Korean-Chinese bilingual children in Yanji, China. Questionnaires were answered by 258 grade four students and their parents. The results indicated that these…

  3. Latino Adolescents' Academic Motivation: The Role of Siblings

    Science.gov (United States)

    Alfaro, Edna C.; Umana-Taylor, Adriana J.

    2010-01-01

    Guided by an ecological perspective, two competing models were tested to examine how sibling relationship quality directly predicted or interacted with academic support from siblings to predict Latino adolescents' academic motivation (N = 258). Gender differences were examined utilizing multiple group analysis in structural equation modeling.…

  4. Colds and the flu - what to ask your doctor - child

    Science.gov (United States)

    ... Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 258. ... Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 379. ...

  5. 76 FR 59446 - Records Schedules; Availability and Request for Comments

    Science.gov (United States)

    2011-09-26

    ..., certification, and testing services. 3. Department of Agriculture, Risk Management Agency (N1-258-08-12, 4 items... management, banking and investment, event planning, library management, and financial planning files. 5... Records Management Services (ACNR) using one of the following means: Mail: NARA (ACNR), 8601 Adelphi...

  6. Survival after a psychoeducational intervention for patients with cutaneous malignant melanoma: a replication study

    DEFF Research Database (Denmark)

    Boesen, Ellen H; Boesen, Sidsel H; Frederiksen, Kirsten

    2007-01-01

    The results of a randomized, intervention study done in 1993 of psychoeducation for patients with early-stage malignant melanoma showed a beneficial effect on recurrence and survival 6 years after the intervention. In the present study, we replicated the study with 258 Danish patients with malign...

  7. Consumer versus expert hazard identification: A mental models study of a functional food ingredient

    DEFF Research Database (Denmark)

    Hagemann, Kit; Scholderer, Joachim

    Objectives: The consumer part of the EU project NOFORISK compares laypeople and experts' understanding of benefits and risks associated with the functional food ingredient Phytosterol. The Council of the European Union has recently authorised the marketing of Phytosterol-enriched rye bread...... as a novel food under Regulation (EC) No 258/97....

  8. Data of evolutionary structure change: 1YLJA-3BLMA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1YLJA-3BLMA 1YLJ 3BLM A A QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDE... 194 LEU CA 258 LEU CA 327 ASN CA 247 3BLM... A 3BLMA LLEQVPYNKL... CA 338 THR CA 465 THR CA 490 3BLM... A 3BLMA KSGQ

  9. Training Valence, Instrumentality, and Expectancy Scale (T-VIES-it): Factor Structure and Nomological Network in an Italian Sample

    Science.gov (United States)

    Zaniboni, Sara; Fraccaroli, Franco; Truxillo, Donald M.; Bertolino, Marilena; Bauer, Talya N.

    2011-01-01

    Purpose: The purpose of this study is to validate, in an Italian sample, a multidimensional training motivation measure (T-VIES-it) based on expectancy (VIE) theory, and to examine the nomological network surrounding the construct. Design/methodology/approach: Using a cross-sectional design study, 258 public sector employees in Northeast Italy…

  10. Equivalency of Paper versus Tablet Computer Survey Data

    Science.gov (United States)

    Ravert, Russell D.; Gomez-Scott, Jessica; Donnellan, M. Brent

    2015-01-01

    Survey responses collected via paper surveys and computer tablets were compared to test for differences between those methods of obtaining self-report data. College students (N = 258) were recruited in public campus locations and invited to complete identical surveys on either paper or iPad tablet. Only minor homogeneity differences were found…

  11. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013 . Scientific Opinion on Rooster Combs Extract

    DEFF Research Database (Denmark)

    Tetens, Inge; Poulsen, Morten

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to carry out the additional assessment for „Rooster Combs Extract‟ (RCE) as a food ingredient in the context of Regulation (EC) No 258/97, taking into account the comment...

  12. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014 . Scientific Opinion on the safety of vitamin D - enriched UV - treated baker‘s yeast

    DEFF Research Database (Denmark)

    Tetens, Inge; Poulsen, Morten

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the safety of “UV-treated baker’s yeast” (Lallemand SAS) as a novel food ingredient in the context of Regulation (EC) No 258/97, taking...

  13. ANALYSIS OF THE EXPRESSION OF MRP, THE GENE FOR A NEW PUTATIVE TRANSMEMBRANE DRUG TRANSPORTER, IN HUMAN MULTIDRUG RESISTANT LUNG-CANCER CELL-LINES

    NARCIS (Netherlands)

    ZAMAN, GJR; VERSANTVOORT, CHM; SMIT, JJM; EIJDEMS, EWHM; DEHAAS, M; SMITH, AJ; BROXTERMAN, HJ; MULDER, NH; DEVRIES, EGE; BAAS, F; BORST, P

    1993-01-01

    Human cells can become multidrug resistant (MDR) by an increase in the activity of the MDR1 P-glycoprotein or by other, as vet unknown mechanisms, referred to as non-P-glycoprotein mediated MDR (non-Pgp MDR). S. P. C. Cole et al. [Science (Washington DC), 258: 1650-1654, 1992] recently reported that

  14. Teaching about Implicit Prejudices and Stereotypes: A Pedagogical Demonstration

    Science.gov (United States)

    Adams, Virgil H., III; Devos, Thierry; Rivera, Luis M.; Smith, Heather; Vega, Luis A.

    2014-01-01

    Social psychology instructors from five distinct state universities in California examined the effect of incorporating the implicit association test (IAT) in a teaching module on students' perceived knowledge of implicit biases and motivation to control prejudice. Students (N = 258) completed a knowledge survey on prejudice, stereotypes, and…

  15. 76 FR 270 - Alaska: Adequacy of Alaska Municipal Solid Waste Landfill Permit Program

    Science.gov (United States)

    2011-01-04

    ... AGENCY 40 CFR Parts 239 and 258 Alaska: Adequacy of Alaska Municipal Solid Waste Landfill Permit Program... modification to Alaska's approved Municipal Solid Waste Landfill (MSWLF) permit program. The approved..., and be free of any defects or viruses. For additional information about EPA's public docket visit the...

  16. Postconcussive Symptoms in OEF/OIF Veterans Presenting to a Polytrauma Clinic with a History of Traumatic Brain Injury

    Science.gov (United States)

    2012-04-25

    prescribed medications of 2.64 (SD = 2.14; (Yasseen, Colantonio, & Ratcliff, 2008). The most prescribed medication types were anti- convulsants (25.8...Clin Neurosci, 18(2), 141-145. doi: 18/2/141 [pii] 10.1176/appi.neuropsych.18.2.141 Tanielian, T. L., & Jaycox, L. (2008). Invisible wounds of war

  17. Data of evolutionary structure change: 1AIFA-2AI0O [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available s_2> 0 n> 1AIF A...n> 1AIFAn> VSSSI----SSSNL n> 2AI0 n>O 2AI...1AIFA-2AI0O 1AIF 2AI0 A O DIQLTQSPAFMAASPGEKVTITCSVSSSI----SSSNLH...e>SER CA 251 SER CA 276 SER CA 258 ASN CA 337 LEU CA 410

  18. Data of evolutionary structure change: 1AIFA-2AI0L [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 2> 0 n> 1AIF n>A ...n>1AIFAn> VSSSI----SSSNL...n> 2AI0 n>L 2AI...1AIFA-2AI0L 1AIF 2AI0 A L DIQLTQSPAFMAASPGEKVTITCSVSSSI----SSSNLH...SER CA 251 SER CA 276 SER CA 258 ASN CA 337 LEU CA 410

  19. Bacterial genetics in meningitis: Associating meningococcal and pneumococcal genes with clinical outcome

    NARCIS (Netherlands)

    Piet, J.R.

    2016-01-01

    The objective of this thesis is to provide more insight in the association of bacterial genetics with clinical characteristics of patients with bacterial meningitis. In a genetic association study using a cohort of 258 meningococcal meningitis patients, we show that specific meningococcal clonal

  20. Disease: H00016 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available is G, Gorgoulis VG Advances in the biology of oral cancer. Oral Oncol 43:523-34 (2007) PMID:18096889 (descri...R, Nagpal JK. Understanding the biology of oral cancer. Med Sci Monit 8:RA258-67 (2002) PMID:17530489 (carci

  1. A Study on Reading Printed Books or E-Books: Reasons for Student-Teachers Preferences

    Science.gov (United States)

    Tosun, Nilgun

    2014-01-01

    This study tried to determine the preferences of student-teachers on reading printed books or e-books and the reasons for these preferences. Reading printed books and e-books preferences of students are discussed in terms of gender and department variables. 258 student-teachers who are studying in Computer Education and Instructional Technologies…

  2. 75 FR 43566 - University of Maryland; Notice of Acceptance for Docketing and Opportunity for Hearing on the...

    Science.gov (United States)

    2010-07-26

    ... Test Reactors Projects Branch, Division of Policy and Rulemaking, Office of Nuclear Reactor Regulation... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR... online form within one business day. (c) A completed Form FD-258 (fingerprint card), signed in...

  3. 75 FR 34769 - The University of Wisconsin; Facility Operating License No. R-74; Notice of Acceptance for...

    Science.gov (United States)

    2010-06-18

    ... INFORMATION CONTACT: Christian Cowdrey, Project Manager, Research and Test Reactors Projects Branch, Division... NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit... FD-258 (fingerprint card), signed in original ink, and submitted in accordance with 10 CFR...

  4. 75 FR 10519 - Notice of License Amendment Request by the Worcester Polytechnic Institute for Approval of the...

    Science.gov (United States)

    2010-03-08

    ... fuel. WPI plans to ship the fuel to another research and test reactor licensed by the NRC. If the NRC... participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August... FD-258 (fingerprint card), signed in original ink, and submitted in accordance with 10 CFR...

  5. 75 FR 36717 - Washington State University; Notice of Acceptance for Docketing and Opportunity for Hearing on...

    Science.gov (United States)

    2010-06-28

    ... Manager, Research and Test Reactors Licensing Branch, Division of Policy and Rulemaking, Office of Nuclear... NRC E Filing rule (72 FR 49139, August 28, 2007). The E Filing process requires participants to submit... FD-258 (fingerprint card), signed in original ink, and submitted in accordance with 10 CFR...

  6. 75 FR 36705 - Regents of the University of California; Notice of Acceptance for Docketing and Opportunity for...

    Science.gov (United States)

    2010-06-28

    ..., Research and Test Reactors Licensing Branch, Division of Policy and Rulemaking, Office of Nuclear Reactor... NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit... online form within one business day. (c) A completed Form FD-258 (fingerprint card), signed in...

  7. Carrier Air Wing Tactics Incorporating Navy Unmanned Combat Air System (NUCAS)

    Science.gov (United States)

    2010-03-01

    MANA. Auckland , New Zealand, January 12, 2010. DeGroot , Morris H. "A Conversation with George Box." Statistical Science, 1987: 239– 258. Ehrhard...wrong, but some are useful”, is an oft quoted phrase from the statistician George E. P. Box ( DeGroot , 1987). The intent of this thesis is to

  8. Developing a Valid Version of an Inventory to Measure Anger in Mexican Adolescents of Middle School Level: The ML-STAXI-MS

    Science.gov (United States)

    Alcázar-Olán, Raúl J.; Deffenbacher, Jerry L.; Escamilla-Tecalco, Héctor

    2016-01-01

    The goals were to develop a valid version of the Multicultural Latin American Inventory of Anger Expression and Hostility (ML-STAXI) for middle school Mexican youth (ML-STAXI-MS) and to test a new Questionnaire about Anger Expression with Physical Aggression (QAEPA). Five hundred and four adolescents (258 males, 246 females); (M[subscript age] =…

  9. Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013

    Science.gov (United States)

    Wang, Shiow-Jen; Yeh, Hung-Yi; Hsieh, Chia-Lun; Lu, Hsueh-Lin; Tseng, Yu-Chuan; Mu, Jung-Jung

    2015-01-01

    The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for detection of the carbapenemase genes, assessment of antimicrobial susceptibility and molecular epidemiology studies. Of these 994 isolates, 183 (18.4%) had carbapenemase genes: 157 (15.8%) KPC (145 KPC-2 and 12 KPC-17), 16 (1.6%) IMP-8, 9 (0.9%) VIM-1, and 1 (0.1%) NDM-1. KPC had the highest prevalence rate among the carbapenemases and represented a major epidemic clone circulating in Taiwan. The ST512 and ST258 KPC-2 KPs were first identified in Taiwan and were grouped into a small cluster in the PFGE profile. In addition, the genetic structure encompassing the blaKPC gene of the ST512 and ST258 isolates showed a different pattern from that of other KPC isolates. ST11 may be a major sequence type circulating in Taiwan, although a specific minor clone has begun to be observed. This is the first report of ST258 and ST512 KPC-2 KP isolates in Taiwan, whether ST258 and ST512 will become the next endemic problems in Taiwan should be closely monitored. PMID:26384242

  10. MONITORING APPROACHES FOR BIOREACTOR LANDFILLS - Report

    Science.gov (United States)

    Experimental bioreactor landfill operations at operating Municipal Solid Waste (MSW) landfills can be approved under the research development and demonstration (RD&D) provisions of 30CFR 258.4. To provide a basis for consistent data collection for future decision-making in suppor...

  11. Investigating Burnout among Elementary and Secondary School Music Educators: A Replication

    Science.gov (United States)

    Bernhard, H. Christian II

    2016-01-01

    The primary purpose of the study was to compare perceived levels of burnout among music educators by grade level taught, state teaching certification status, and music specialization. The secondary purpose was to examine relationships among perceived burnout, and academic as well as personal variables. Participants for the study were 258

  12. October, 2009 ISSN 1994-9057 (Print) ISSN 2070-0083

    African Journals Online (AJOL)

    Nekky Umera

    Biology, Chemistry and Economics in 2004, 2005, 2006 and 2007 were obtained. These questions ... Prior to independence, and for some years after it, the West African ..... 0-000-000-2005-Web/JSS-11-3-173-258-2005-Abst-PDF/JSS-11-3-.

  13. Domain Modeling: NP_776173.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available BETP FROM CORYNEBACTERIUM GLUTAMICUM WITH BOUND SUBSTRATE p2wita_ chr12/NP_776173.3/NP_776173.3_holo_80-636.pdb swppa 252L,254G,255L,256M,258G,259L,270T,335V,402L,403L,440L BET 0 ...

  14. 75 FR 53268 - Adequacy of New Hampshire Municipal Solid Waste Landfill Permit Program

    Science.gov (United States)

    2010-08-31

    ... AGENCY 40 CFR Parts 239 and 258 Adequacy of New Hampshire Municipal Solid Waste Landfill Permit Program... approve New Hampshire's modification of its approved Municipal Solid Waste Landfill Program. On March 22... be issued to certain municipal solid waste landfills by approved states. On June 28, 2010...

  15. 76 FR 303 - Alaska: Adequacy of Alaska's Municipal Solid Waste Landfill Permit Program

    Science.gov (United States)

    2011-01-04

    ... AGENCY 40 CFR Parts 239 and 258 Alaska: Adequacy of Alaska's Municipal Solid Waste Landfill Permit... proposes to approve Alaska's modification of its approved Municipal Solid Waste Landfill (MSWLF) permit... Domenic Calabro, Office of Air, Waste, and Toxics, U.S. EPA, Region 10, 1200 Sixth Avenue, Suite...

  16. 78 FR 5350 - Adequacy of Massachusetts Municipal Solid Waste Landfill Permit Program

    Science.gov (United States)

    2013-01-25

    ... AGENCY 40 CFR Parts 239 and 258 Adequacy of Massachusetts Municipal Solid Waste Landfill Permit Program... approve Massachusetts's modification of its approved Municipal Solid Waste Landfill Program. On March 22... be issued to certain municipal solid waste landfills by approved states. On December 7,...

  17. 78 FR 5288 - Adequacy of Massachusetts Municipal Solid Waste Landfill Permit Program

    Science.gov (United States)

    2013-01-25

    ... AGENCY 40 CFR Parts 239 and 258 Adequacy of Massachusetts Municipal Solid Waste Landfill Permit Program... modification to Massachusetts's approved municipal solid waste landfill (MSWLF) program. The approved... INFORMATION: A. Background On March 22, 2004, EPA issued a final rule amending the municipal solid...

  18. Research

    African Journals Online (AJOL)

    abp

    8 oct. 2015 ... Key words: Paramètres entomologiques, bioécologiques, anopheles gambiae. Received: 09/04/2015 ..... Il a été répartis en 1.258 anophèles et 3.330 culex ont été identifiés ..... Pupal habitat productivity of anopheles gambiae ...

  19. The Effects of Psychopathology on the Pain Expression of Children and Youth with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Breau, Lynn M.; Camfield, Carol S.

    2011-01-01

    Behavioral pain assessment is possible for children and youth with intellectual and developmental disabilities (IDD). However, pain behavior is often misinterpreted as reflecting psychopathology. We examined whether psychopathology alters pain behavior. Caregivers of 123 children (56 girls ages 40 to 258 months) completed the Non-Communicating…

  20. Unauthorized Disclosure: Can Behavioral Indicators Help Predict Who Will Commit Unauthorized Disclosure of Classified National Security Information?

    Science.gov (United States)

    2015-06-01

    capture had triggered borderline obsessive- compulsive traits.”235 Montes’s sister wrote of her betrayal, You betrayed your family, you betrayed all...Libya.258 However, unable to find a buyer for the large volume of classified information he had amassed, Regan buried it. At his trial, officials

  1. Multifractal Internet Traffic Model and Active Queue Management

    Science.gov (United States)

    2003-01-01

    there have been some modifications such as Stabilized RED ( SRED ) [93], Flow RED (FRED) [94], Weighted RED [95], Random Early Marking (REM) [38], BLUE...La, “Nonlinear instabilities in TCP-RED,” in Proceedings of INFOCOM, 2002, pp. 249 –258. [93] T.J. Ott, T.V. Lakshman, and L.H. Wong, “ SRED : Stabilized

  2. La invención del catolicismo en América. Los procesos de evangelización, siglos XVI-XVIII. [Reseña

    OpenAIRE

    Benito-Rodríguez, J.A. (José Antonio)

    2010-01-01

    Reseña de: Fernando Armas Asín (ed.), La invención del catolicismo en América. Los procesos de evangelización, siglos XVI-XVIII, Universidad Nacional Mayor de San Marcos – Fondo Editorial de la Facultad de Ciencias Sociales, Lima 2009, 258 pp.

  3. Dicty_cDB: Contig-U14702-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cymaae clone CH258-143M4, WORKING DRAFT ... 44 5.2 1 ( AC186951 ) Loxodonta africana clone VMRC15-414C10, WO...nolophus ferrumequinum clone VMRC7-116J5, WORK... 44 5.2 1 ( AC166890 ) Loxodonta africana clone VMRC15-222I

  4. Tobacco use, alcohol consumption and infertility

    DEFF Research Database (Denmark)

    Olsen, J; Rachootin, P; Schiødt, A V

    1983-01-01

    for infertility at Odense University Hospital during the period 1977-1980 were eligible for participation as cases. A control group was chosen consisting of 4305 women who had each delivered a healthy child with a gestational age over 258 days at the same hospital in the period 1977-1979. Data regarding...

  5. The Investigation of Relationship among Relational-Interdependent Self-Construal, Cyberbullying, and Psychological Disharmony in Adolescents: An Investigation of Structural Equation Modelling

    Science.gov (United States)

    Cetin, Bayram; Eroglu, Yuksel; Peker, Adem; Akbaba, Sirri; Pepsoy, Sevim

    2012-01-01

    The aim of this study is to investigate the effect of relational-interdependent self-construal on cyberbullying and the effect of cyberbullying on psychological disharmony. Participants were 258 high school students. In this study, the Relational-Interdependent Self-Construal Scale, the Revised Cyberbullying Inventory, and the Depression, Anxiety,…

  6. La edad de la empatía. Lecciones de la naturaleza para una sociedad más justa y solidaria, por Fran de Waal

    Directory of Open Access Journals (Sweden)

    Cecilia Milito Barone

    2015-07-01

    Full Text Available Rsseña del libro Fran de Waal, La edad de la empatía. Lecciones de la naturaleza para una sociedad más justa y solidaria (Barcelona: Tusquets Editores, 2011, 258 pp. ISBN: 978-84-8383-350-6

  7. Data of evolutionary structure change: 1DCLB-3CVIL [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DCLB-3CVIL 1DCL 3CVI B L PSALTQP-PSASGSLGQSVTISCTGTSSNVGGYNYVSWY...ine>TYR CA 333 ALA CA 311 3CVI... L 3CVIL TDQDSKDSTYS VAL CA 258 GLU CA 293 3CVI L 3CVIL EATHKTSTSPIV

  8. Metropolitan Washington Area Water Supply Study. Appendix B. Plan Formulation, Assessment, and Evaluation.

    Science.gov (United States)

    1983-09-01

    Behavoir Mod. 0 0 0 0 Outdoor Behavoir Mod. 0 0 0 0 Non-Residential Behavoir Mod. 0 0 0 0 Siphon-Jet Toilets 22,690 57,487.9 86,258.7 16,643.6 Shower...financial, organizational , and political influences often represent the overriding factors which determine the success or failure " of any proposed plan

  9. Structural and Functional Analysis of HIV-1 Coreceptors: Roles of Charged Residues and Posttranslational Modifications on Coreceptor Activity

    Science.gov (United States)

    2000-01-01

    Peiper. 1997. From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen. Blood. 89:3077-91. 131. Harouse, f...1983. Tyrosine-O-sulfated proteins of PC12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase. J Biol Chem. 258:11326

  10. An Investigation of Anger and Anger Expression in Terms of Coping with Stress and Interpersonal Problem-Solving

    Science.gov (United States)

    Arslan, Coskun

    2010-01-01

    The purpose of this study was to investigate the anger and anger expression styles with respect to coping with stress and interpersonal problem-solving. The participants were 468 (258 female and 210 male, between 17-30 years old) university students. Pearson product-moment correlation coefficients and multiple hierarchical regression analysis were…

  11. Developing a Valid Version of an Inventory to Measure Anger in Mexican Adolescents of Middle School Level: The ML-STAXI-MS

    Science.gov (United States)

    Alcázar-Olán, Raúl J.; Deffenbacher, Jerry L.; Escamilla-Tecalco, Héctor

    2016-01-01

    The goals were to develop a valid version of the Multicultural Latin American Inventory of Anger Expression and Hostility (ML-STAXI) for middle school Mexican youth (ML-STAXI-MS) and to test a new Questionnaire about Anger Expression with Physical Aggression (QAEPA). Five hundred and four adolescents (258 males, 246 females); (M[subscript age] =…

  12. Convergence, Admissibility, and Fit of Alternative Confirmatory Factor Analysis Models for MTMM Data

    Science.gov (United States)

    Lance, Charles E.; Fan, Yi

    2016-01-01

    We compared six different analytic models for multitrait-multimethod (MTMM) data in terms of convergence, admissibility, and model fit to 258 samples of previously reported data. Two well-known models, the correlated trait-correlated method (CTCM) and the correlated trait-correlated uniqueness (CTCU) models, were fit for reference purposes in…

  13. The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

    DEFF Research Database (Denmark)

    Sako, Masao; Bassett, Bruce; C. Becker, Andrew

    2014-01-01

    This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS S...

  14. AcEST: DK960375 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ibonucleoprotein 200 kDa ... 258 2e-68 sp|Q9VUV9|U520_DROME Putative U5 small nuclear ribonucleoprotein... 2...I-EKKNFPFERLYDL 1156 >sp|Q9VUV9|U520_DROME Putative U5 small nuclear ribonucleoprotein 200 kDa helicase OS=D

  15. Factors Associated with Teenagers' Willingness to Volunteer with Elderly Persons: Application of the Theory of Planned Behavior (TPB)

    Science.gov (United States)

    Reuveni, Yehudit; Werner, Perla

    2015-01-01

    The purpose of this study was to investigate the factors associated with teenagers' willingness to volunteer with elderly persons using an expanded model of the Theory of Planned Behavior (TPB). Participants consisted of 258 ninth-grade students at a large high school in the northern part of Israel. Participants completed a structured…

  16. EST Table: FY744442 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY744442 E_FL_famL_24B15_F_0 11/11/04 100 %/258 aa ref|NP_001040494.1| U2 small nuc...a Y92C3B.2d#CE30403#WBGene00006697#locus:uaf- 1#status:Confirmed#UniProt:Q8MXS2#protein_id:AAM444

  17. Sediment boron and its relation to sediment properties in a tropical estuary

    Digital Repository Service at National Institute of Oceanography (India)

    Shirodkar, P.V.; Dalal, V.N.K.

    Boron in the sediments of Mandovi estuary varied from 8.0 to 258.0 ppm with an average of 118 ppm. It showed an inverse relation to the texture of sediments and was found to be concentrated in silt and clay fraction with generally decreasing...

  18. Teaching about Implicit Prejudices and Stereotypes: A Pedagogical Demonstration

    Science.gov (United States)

    Adams, Virgil H., III; Devos, Thierry; Rivera, Luis M.; Smith, Heather; Vega, Luis A.

    2014-01-01

    Social psychology instructors from five distinct state universities in California examined the effect of incorporating the implicit association test (IAT) in a teaching module on students' perceived knowledge of implicit biases and motivation to control prejudice. Students (N = 258) completed a knowledge survey on prejudice, stereotypes, and…

  19. CNGA3 mutations in hereditary cone photoreceptor disorders

    NARCIS (Netherlands)

    Wissinger, B; Gamer, D; Jagle, H; Giorda, R; Marx, T; Mayer, S; Tippmann, S; Broghammer, M; Jurklies, B; Rosenberg, T; Jacobson, SG; Sener, EC; Tatlipinar, S; Hoyng, CB; Castellan, C; Bitoun, P; Andreasson, S; Rudolph, G; Kellner, U; Lorenz, B; Wolff, G; Verellen-Dumoulin, C; Schwartz, M; Cremers, FPM; Apfelstedt-ylla, E; Zrenner, E; Salati, R; Sharpe, LT; Kohl, S

    2001-01-01

    We recently showed that mutations in the CNGA3 gene encoding the alpha -subunit of the cone photoreceptor cGMP-gated channel cause autosomal recessive complete achromatopsia linked to chromosome 2q11. We now report the results of a first comprehensive screening for CNGA3 mutations in a cohort of 258

  20. Presentation of chronic daily headache : A clinical study

    NARCIS (Netherlands)

    Spierings, E L H; Schroevers, M.; Honkoop, P.C.; Sorbi, M.

    1998-01-01

    We studied the presentation of chronic daily headache in 258 patients from a private headache practice, 50 men and 208 women. Chronic daily headache was defined as headaches, occurring at least 5 days per week for at least 1 year. Seventy-seven percent of the patients experienced the onset of headac

  1. On the thermodynamical admissibility of the triphasic theory of charged hydrated tissues

    NARCIS (Netherlands)

    Huyghe, J.M.; Wilson, W.; Malakpoor, K.

    2009-01-01

    The triphasic theory on soft charged hydrated tissues (Lai, W. M., Hou, J. S., and Mow, V. C., 1991, "A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage," ASME J. Biomech. Eng., 113, pp. 245-258) attributes the swelling propensity of articular cartilage to three dif

  2. MONITORING APPROACHES FOR BIOREACTOR LANDFILLS - Report

    Science.gov (United States)

    Experimental bioreactor landfill operations at operating Municipal Solid Waste (MSW) landfills can be approved under the research development and demonstration (RD&D) provisions of 30CFR 258.4. To provide a basis for consistent data collection for future decision-making in suppor...

  3. Knowledge of Chlamydial Infection among University Students.

    Science.gov (United States)

    White, David M.; Felts, W. Michael

    1989-01-01

    Results of a study designed to assess knowledge about chlamydial infection among university students (N=258) revealed serious gaps in knowledge. Data suggests that students held several misconceptions, or had no knowledge, regarding symptoms, transmission, treatment, and testing for chlamydial infection. (IAH)

  4. Fission life-time calculation using a complex absorbing potential

    Directory of Open Access Journals (Sweden)

    Scamps Guillaume

    2016-01-01

    Full Text Available A comparison between the semi-classical approximation and the full quantum calculation with a complex absorbing potential is made with a model of the fission of 258Fm. The potential barrier is obtained with the constrained Skyrme HF+BCS theory. The life-time obtained by the two calculations agree with each other the difference being only by 25%.

  5. A Causal Model of Teacher Acceptance of Technology

    Science.gov (United States)

    Chang, Jui-Ling; Lieu, Pang-Tien; Liang, Jung-Hui; Liu, Hsiang-Te; Wong, Seng-lee

    2012-01-01

    This study proposes a causal model for investigating teacher acceptance of technology. We received 258 effective replies from teachers at public and private universities in Taiwan. A questionnaire survey was utilized to test the proposed model. The Lisrel was applied to test the proposed hypotheses. The result shows that computer self-efficacy has…

  6. Hot or Not: An Analysis of Online Professor-Shopping Behavior of Business Students

    Science.gov (United States)

    Hossain, Tarique M.

    2010-01-01

    With the proliferation of Web sites that allow students to praise or disparage their instructors depending on their whims, instructors across the country essentially are becoming subjects of comparison shopping by prospective students. Using a sample survey of 258 students majoring in business at a public university on the west coast of the United…

  7. A new regime of the Agulhas Current Retroflection: Turbulent Choking of Indian-Atlantic leakag

    NARCIS (Netherlands)

    le Bars, D.L.B.|info:eu-repo/dai/nl/326165150; de Ruijter, W.P.M.|info:eu-repo/dai/nl/068476760; Dijkstra, H.A.|info:eu-repo/dai/nl/073504467

    2012-01-01

    An analysis of the Indian Ocean circulation and the Agulhas Current retroflection is carried out using a primitive equation model with simplified coastline and flat bottom. Four configurations with 0.258 and 0.18 horizontal resolution and in barotropic and baroclinic cases are considered. The wind

  8. Comparing Benefit Estimation Techniques: Residential Flood Hazard Reduction Benefits in Roanoke, Virginia

    Science.gov (United States)

    1998-03-01

    Experimental Study of Insurance Decisions." Journal of Risk and Insurance . 46 (1979): 603-618. Senjem, N. and D. Freshwater, "The Capitalization of Flood...Implications: Journal of Risk and Insurance . 44 (1977): 237-258. Slovic, P., D. Griffin, and A. Tversky. "Compatibility Effects in Judgement and Choice." in

  9. Quality of bulk tank milk samples from Danish dairy herds based on real-time polymerase chain reaction identification of mastitis pathogens

    DEFF Research Database (Denmark)

    Katholm, Jørgen; Bennedsgaard, T.W.; Koskinen, M.T.;

    2012-01-01

    Results of a commercial real-time PCR analysis for 11 mastitis pathogens from bulk tank milk (BTM) samples from all 4,258 Danish dairy herds in November 2009 to January 2010 were compared with somatic cell count (SCC) and total bacteria count (TBC) estimates in BTM. For Streptococcus agalactiae, ...

  10. Effects of Prostate Cancer Screening and Treatment

    NARCIS (Netherlands)

    E.M. Wever (Elisabeth)

    2012-01-01

    textabstractProstate cancer is the second most frequently diagnosed cancer of men worldwide. The number of new cases worldwide was estimated at 899,000 and accounted for 13.6% of all cancers in men in 2008. With an estimated 258,000 deaths in 2008, prostate cancer is the sixth leading cause of death

  11. Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study

    DEFF Research Database (Denmark)

    Hasle, Henrik; Alonzo, Todd A; Auvrignon, A

    2007-01-01

    Monosomy 7 (-7) and deletion 7q \\del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations \\+/- other...

  12. Data of evolutionary structure change: 1CIJA-2PSDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CIJA-2PSDA 1CIJ 2PSD A A MVNAIRTP-----------DQRFSNLDQYPFSPNYLDDL...ADPSRFKRLIIMNACLMTDPVTQPAFSAFVTQPADGFTAWKYDLVTPSDLRLD-----------QFMKRWAPT-LTEAEASAYAAPFP--DTSYQAGVRKFPKMVA--...ne> LEU CA 574 2PSD... A 2PSDA ELLNLPKKIIF GLN CA 210 ALA CA 258 2PSD

  13. Physicochemical properties and amylopectin chain profiles of cowpea, chickpea and yellow pea starches

    NARCIS (Netherlands)

    Huang, J.; Schols, H.A.; Soest, van J.J.G.; Jin, Z.; Sulmann, E.; Voragen, A.G.J.

    2007-01-01

    Starches from cowpea and chickpea seeds were isolated and their properties were compared with those of commercial yellow pea starch. Amylose contents were 25.8%, 27.2%, and 31.2%, and the volume mean diameter of granules, determined in the dry state, were 15.5, 17.9, and 33.8 ¿m for cowpea, chickpea

  14. Domain Modeling: NP_057507.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_057507.2 chr14 Aart, a six finger zinc finger designed to recognize ANN triplets... c2i13b_ chr14/NP_057507.2/NP_057507.2_holo_27-178.pdb psi-blast 254R,256A,257T,258P,259T,260P,263A,265P,276

  15. Physicochemical properties and amylopectin chain profiles of cowpea, chickpea and yellow pea starches

    NARCIS (Netherlands)

    Huang, J.; Schols, H.A.; Soest, van J.J.G.; Jin, Z.; Sulmann, E.; Voragen, A.G.J.

    2007-01-01

    Starches from cowpea and chickpea seeds were isolated and their properties were compared with those of commercial yellow pea starch. Amylose contents were 25.8%, 27.2%, and 31.2%, and the volume mean diameter of granules, determined in the dry state, were 15.5, 17.9, and 33.8 ¿m for cowpea, chickpea

  16. Children's Adjustment Problems in Families Characterized by Men's Severe Violence toward Women: Does Other Family Violence Matter?

    Science.gov (United States)

    McDonald, Renee; Jouriles, Ernest N.; Tart, Candyce D.; Minze, Laura C.

    2009-01-01

    Objective: This research examined whether additional forms of family violence (partner-child aggression, mother-child aggression, and women's intimate partner violence [IPV]) contribute to children's adjustment problems in families characterized by men's severe violence toward women. Methods: Participants were 258 children and their mothers…

  17. Immunomodulation by probiotics: efficacy and safety evaluation

    NARCIS (Netherlands)

    Ezendam J; Opperhuizen A; Loveren H van; TOX

    2005-01-01

    Probiotics are non-pathogenic bacteria that are used as functional food components with claimed health-promoting effects. In the European Union probiotics are regulated via the Novel Foods Regulation (258/97/EC). This regulation is only applied to strains that were not used before 1997 and concerns

  18. Gclust Server: 86060 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 86060 Atu_Atu1539=hvsT Cluster Sequences Related Sequences(258) 537 sulfate permeas...e 1 1.00e-28 0.0 0.0 0.0 0.0 3.23 0.0 Show 86060 Cluster ID 86060 Sequence ID Atu_Atu1539=hvsT Link to clust

  19. Factors Associated with Teenagers' Willingness to Volunteer with Elderly Persons: Application of the Theory of Planned Behavior (TPB)

    Science.gov (United States)

    Reuveni, Yehudit; Werner, Perla

    2015-01-01

    The purpose of this study was to investigate the factors associated with teenagers' willingness to volunteer with elderly persons using an expanded model of the Theory of Planned Behavior (TPB). Participants consisted of 258 ninth-grade students at a large high school in the northern part of Israel. Participants completed a structured…

  20. Endocardial and pericardial disease

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920664 Serious complications and potentialdanger of endomyocardial biopsy.QUNailu (曲乃路), et al. Cardiovascular Dept,Dalian Centr Hosp, Dalian. Chin Cir J1992; 7(3): 257-258. Endomyocardial biopsy(EMB)of 86 patients,aged 15-57 yrs; has been prerformed in this

  1. Two Degrees: The Built Environment and Our Changing Climate

    Directory of Open Access Journals (Sweden)

    Steve Harfield

    2013-06-01

    Full Text Available McGregor, Alisdair, Roberts, Cole & Cousins, Fiona, Abingdon: Routledge, 2013, ISBN 978-00415-69300-4 (paperback, i – xviii, 1- 258 pages, USD 54.95 (hard cover 170.00, e-Book 54.95, GBP 34.99 (hard cover 105.00, e-Book 34.99

  2. Rapid screening for carriage of methicillin-resistant Staphylococcus aureus by PCR and associated costs.

    Science.gov (United States)

    Bühlmann, Manuela; Bögli-Stuber, Katja; Droz, Sara; Mühlemann, Kathrin

    2008-07-01

    PCR tests for the rapid and valid detection of methicillin-resistant Staphylococcus aureus (MRSA) are now available. We evaluated the costs associated with contact screening for MRSA carriage in a tertiary-care hospital with low MRSA endemicity. Between 1 October 2005 and 28 February 2006, 232 patients were screened during 258 screening episodes (644 samples) for MRSA carriage by GenoType MRSA Direct (Hain Lifescience GmbH, Nehren, Germany). Conventional culture confirmed all PCR results. According to in-house algorithms, 34 of 258 screening episodes (14.7%) would have qualified for preemptive contact isolation, but such isolation was not done upon negative PCR results. MRSA carriage was detected in 4 (1.5%) of 258 screening episodes (i.e., in four patients), of which none qualified for preemptive contact isolation. The use of PCR for all 258 screening episodes added costs (in Swiss francs [CHF]) of CHF 104,328.00 and saved CHF 38,528.00 (for preemptive isolation). The restriction of PCR screening to the 34 episodes that qualified for preemptive contact isolation and screening all others by culture would have lowered costs for PCR to only CHF 11,988.00, a savings of CHF 38,528.00. Therefore, PCR tests are valuable for the rapid detection of MRSA carriers, but high costs require the careful evaluation of their use. In patient populations with low MRSA endemicity, the broad use of PCR probably is not cost-effective.

  3. Reduction of the treated volume to involved node radiation therapy as part of combined modality treatment for early stage aggressive non-Hodgkin's lymphoma.

    NARCIS (Netherlands)

    Verhappen, M.H.; Poortmans, P.M.; Raaijmakers, E.; Raemaekers, J.M.M.

    2013-01-01

    BACKGROUND AND PURPOSE: This retrospective study investigated whether focused involved node radiation therapy (INRT) can safely replace involved field RT (IFRT) in patients with early stage aggressive NHL. PATIENTS AND METHODS: We included 258 patients with stage I/II aggressive NHL who received com

  4. Design of Gages for Direct Skin Friction Measurements in Complex Turbulent Flows with Shock Impingement Compensation

    Science.gov (United States)

    2007-06-07

    www.ansys.com/ 30 Figliola, p. 87-91. 31 Pilkey, p. 564. 32 Fogiel, p. 1112. 33 Hibbeler , R.C. Engineering Mechanics Static and Dynamics 5th Edition...Macmillan Publishing Company, Inc., New York, 1989 pp. 486, 511. 34 Hibbeler , pp. 486, 511. 35 Figliola, p. 89. 36 Fogiel, p. 258. 37

  5. A Computer-Based Visual Analog Scale,

    Science.gov (United States)

    1992-06-01

    Methamphetamine, Ephedrine , Phenmetrazine, and methylphenidate in Man." Clinical Pharmacology and Therapeutics, Vol. 12, pp. 245-258, 1971. 11...8217. SYMPTOM.EXE reads the input path’s directory, looking for matches to the file-specification. If it finds no matches, it will abort with a message. Otherwise

  6. Fingerprint Analysis with Marked Point Processes

    DEFF Research Database (Denmark)

    Forbes, Peter G. M.; Lauritzen, Steffen; Møller, Jesper

    We present a framework for fingerprint matching based on marked point process models. An efficient Monte Carlo algorithm is developed to calculate the marginal likelihood ratio for the hypothesis that two observed prints originate from the same finger against the hypothesis that they originate from...... different fingers. Our model achieves good performance on an NIST-FBI fingerprint database of 258 matched fingerprint pairs....

  7. Botanical galactogogues: nutritional values and therapeutic potentials

    African Journals Online (AJOL)

    SARAH

    2013-01-31

    Jan 31, 2013 ... Conclusions and application of findings: This study has contributed to ... They could be used for the treatment of diarrhoea and pneumonia reportedly to be major causes ..... affect the walls of the stomach and other digestive parts, they sour ..... Pakistan. Journal of Nutrition 8 (3): 256–258. Jenness R, 1979.

  8. ¿Está okey el español?

    Directory of Open Access Journals (Sweden)

    Silvia María Cristancho Bernal

    1993-09-01

    Full Text Available Encuentro internacional sobre el español de América. Presencia y destino. El español de América hacia el siglo XXI. Tomo II. Varios autores Instituto Caro y Cuervo, Santafé de Bogotá, 1992, 258 págs.

  9. 21.4.Mental deficiency

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920201 Assessment of Hasegawa’s demen-tia scale for screening and diagnosing de-mentia in the elderly.GAO Zhixu (高之旭),etal.Shanghai Ment Health Center,Shanghai,200030.Chin J Neurol & Psychiat 1991; 24 (5):258-261.A sample of 2573 elder inhabitants in Shanghai

  10. Parent-Child Cultural Orientations and Child Adjustment in Chinese American Immigrant Families

    Science.gov (United States)

    Chen, Stephen H.; Hua, Michelle; Zhou, Qing; Tao, Annie; Lee, Erica H.; Ly, Jennifer; Main, Alexandra

    2014-01-01

    Direct and indirect/mediated relations of (a) children's and parents' cultural orientations and (b) parent-child gaps in cultural orientations to children's psychological adjustment were examined in a socioeconomically diverse sample of 258 Chinese American children (age = 6-9 years) from immigrant families. Parents reported on…

  11. Social Cognitive Predictors of Mexican American High School Students' Math/Science Career Goals

    Science.gov (United States)

    Garriott, Patton O.; Raque-Bogdan, Trisha L.; Zoma, Lorrine; Mackie-Hernandez, Dylan; Lavin, Kelly

    2017-01-01

    This study tested a social cognitive model of math/science career goals in a sample (N = 258) of Mexican American high school students. Familism and proximal family supports for math/science careers were examined as predictors of math/science: performance accomplishments, self-efficacy, interests, and goals. Results showed that the hypothesized…

  12. Data of evolutionary structure change: 1IBHA-1XTLB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available Chain>A 1IBHA LSQNK-YGVVF e>...nce>IKESDDEGLDI >EE EEEE> ATOM 1...bID> A 1IBHA ADLTP-GIHGF ...> -EEEEE> ATOM 258 CA ALA A 35 37.700 41.556 27.473 1.0...IDChain> NSLRPGASLGF > EEEEE>

  13. How to make the medical consultation more successful from a patient's perspective? Tips for doctors and patients from lay people in the United Kingdom, Italy, Belgium and the Netherlands.

    NARCIS (Netherlands)

    Bensing, J.M.; Deveugele, M.; Moretti, F.; Fletcher, I.; Vliet, L. van; Bogaert, M. van; Rimondini, M.

    2011-01-01

    Objective: The aim of this study is to generate empirically based 'tips' from lay people on how medical consultations could become more successful from a patient perspective. Methods: 258 Lay people in the United Kingdom, Italy, Belgium and the Netherlands, distributed over 32 focus groups, were inv

  14. Anxiety, depression, and perception of early parenting: A meta-analysis. Erratum

    NARCIS (Netherlands)

    Gerlsma, C.; Emmelkamp, P.M.G.; Arrindell, W.A.

    1991-01-01

    Reports an error in the original article by C. Gerlsma et al (Clinical Psychology Review, 1990, Vol 10[3], 251-277). Corrections are made to the 1st and 3rd formulas on page 257 and to Table 1, page 258, and Table 1, page 261."

  15. AcEST: DK958625 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ase 5 OS=Arabidops... 123 8e-28 sp|Q9LJM4|IKU2_ARATH Receptor-like protein kinase HAIKU2 OS=Arab... 123 8e-2...GSIPSWITQ 258 >sp|Q9LJM4|IKU2_ARATH Receptor-like protein kinase HAIKU2 OS=Arabidopsis thaliana GN=IKU2 PE=1

  16. Attitudes toward Older People and Coworkers' Intention to Work with Older Employees: A Taiwanese Study

    Science.gov (United States)

    Lu, Luo

    2010-01-01

    The aim of this research was to examine attitudinal barriers to the employment of Taiwanese older workers (aged 60 and above). Face-to-face interviews were conducted to collect data using structured questionnaires from a sample of full-time employees (N = 258). We found that: (1) positive attitudes toward older people in general, perceived…

  17. CNGA3 mutations in hereditary cone photoreceptor disorders

    NARCIS (Netherlands)

    Wissinger, B; Gamer, D; Jagle, H; Giorda, R; Marx, T; Mayer, S; Tippmann, S; Broghammer, M; Jurklies, B; Rosenberg, T; Jacobson, SG; Sener, EC; Tatlipinar, S; Hoyng, CB; Castellan, C; Bitoun, P; Andreasson, S; Rudolph, G; Kellner, U; Lorenz, B; Wolff, G; Verellen-Dumoulin, C; Schwartz, M; Cremers, FPM; Apfelstedt-ylla, E; Zrenner, E; Salati, R; Sharpe, LT; Kohl, S

    2001-01-01

    We recently showed that mutations in the CNGA3 gene encoding the alpha -subunit of the cone photoreceptor cGMP-gated channel cause autosomal recessive complete achromatopsia linked to chromosome 2q11. We now report the results of a first comprehensive screening for CNGA3 mutations in a cohort of 258

  18. Best practices for learning video concept detectors from social media examples (Author’s Manuscript)

    Science.gov (United States)

    2014-05-23

    In: MIR 249–258 12. Kim J, Pavlovic V (2012) Attribute rating for classification of visual objects. In: ICPR 1611–1614 13. Kordumova S, Li X, Snoek... theory . Wiley, New York 40. Wang H, Schmid C (2013) Action recognition with improved trajectories. In: ICCV 3551–3558 41. Wang Z, ZhaoM, SongY, Kumar S, Li

  19. America's Star Libraries: Top-Rated Libraries

    Science.gov (United States)

    Lance, Keith Curry; Lyons, Ray

    2009-01-01

    "Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

  20. America's Star Libraries, 2010: Top-Rated Libraries

    Science.gov (United States)

    Lyons, Ray; Lance, Keith Curry

    2010-01-01

    The "LJ" Index of Public Library Service 2010, "Library Journal"'s national rating of public libraries, identifies 258 "star" libraries. Created by Ray Lyons and Keith Curry Lance, and based on 2008 data from the IMLS, it rates 7,407 public libraries. The top libraries in each group get five, four, or three stars. All included libraries, stars or…

  1. Fundamentals of Chemistry at Surfaces and Beyond

    Science.gov (United States)

    2013-09-23

    Identification of a Wagging Vibrational Mode of Water Molecules at the Water/Vapor Interface,” Phys. Rev. E (Stat., Nonlinear, Soft Matter Phys...of the Water Surface,” Chem. Phys., 258, 371-390 (2000). 54A. Perry, C. Neipert, C. Ridley, B. Space, “Identification of a Wagging Vibrational Mode

  2. Health beliefs and teenage condom use : A prospective study

    NARCIS (Netherlands)

    Abraham, CS; Sheeran, P; Abrams, D; Spears, R

    1996-01-01

    Results from a longitudinal survey of sexual behaviour and HIV-relevant cognitions amongst 258 sexually-active adolescents are reported. Demographic characteristics, previous sexual experience, prior condom use, beliefs specified by the health belief model (I-IBM), peer norms regarding condom use an

  3. An integrated chemo-enzymatic route for preparation of ß-thymidine, a key intermediate in the preparation of antiretrovirals

    CSIR Research Space (South Africa)

    Gordon, GER

    2011-01-01

    Full Text Available -1 Organic Process Research & Development 2011, 15, 258?265 An Integrated Chemo-enzymatic Route for Preparation of ?-Thymidine, a Key Intermediate in the Preparation of Antiretrovirals Gregory E. R. Gordon,? Moira L. Bode,*,? Daniel F. Visser,? M. Jerry...

  4. Remotely sensed phenology for mapping biomes and vegetation functional types

    CSIR Research Space (South Africa)

    Wessels, Konrad J

    2009-07-01

    Full Text Available techniques," Remote Sensing of Environment, vol. 113, pp. 248-258, 2009. [9] M. A. White, K. M. De Beurs , K. D. Idan, D. W. Inouy, A. D . Richardson, O. P. Jensen, J. O'Keef, G. Zhang, R. R. Nemani, W.J. D . Van Leeuwen, J. F. Brown, A. De wit, M...

  5. The Effects of Psychopathology on the Pain Expression of Children and Youth with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Breau, Lynn M.; Camfield, Carol S.

    2011-01-01

    Behavioral pain assessment is possible for children and youth with intellectual and developmental disabilities (IDD). However, pain behavior is often misinterpreted as reflecting psychopathology. We examined whether psychopathology alters pain behavior. Caregivers of 123 children (56 girls ages 40 to 258 months) completed the Non-Communicating…

  6. Training Valence, Instrumentality, and Expectancy Scale (T-VIES-it): Factor Structure and Nomological Network in an Italian Sample

    Science.gov (United States)

    Zaniboni, Sara; Fraccaroli, Franco; Truxillo, Donald M.; Bertolino, Marilena; Bauer, Talya N.

    2011-01-01

    Purpose: The purpose of this study is to validate, in an Italian sample, a multidimensional training motivation measure (T-VIES-it) based on expectancy (VIE) theory, and to examine the nomological network surrounding the construct. Design/methodology/approach: Using a cross-sectional design study, 258 public sector employees in Northeast Italy…

  7. A Ten Year Follow-up of Attitudes toward Evaluation in Behavioral Aspects of Clinical Practice.

    Science.gov (United States)

    Grace, Edward G.; Cohen, Leonard A.

    1991-01-01

    Repetition of a 1979 survey of University of Maryland at Baltimore dental school students (n=258) and faculty (n=120) concerning student evaluation in behavioral science content found more favorable student responses, little change in faculty attitudes toward the importance of behavioral sciences, and more interest in evaluating students on…

  8. Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates

    NARCIS (Netherlands)

    Spaapen, LJM; Bakker, JA; Velter, C; Loots, W; Rubio-Gonzalbo, ME; Forget, PP; Dorland, L; De Koning, TJ; Poll-The, BT; Van Amstel, HKP; Bekhof, J; Blau, N; Duran, M

    2001-01-01

    Four neonates with a positive phenylalanine screening test (Phe concentrations between 258 and 1250 mu mol/L) were investigated further to differentiate between phenylalanine hydroxylase (PAH) deficiency and variant hyperphenylalaninaemia (HPA) forms. In patients 1 and 2 a tetrahydrobiopterin (BH4)

  9. Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013.

    Directory of Open Access Journals (Sweden)

    I-Ling Tseng

    Full Text Available The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for detection of the carbapenemase genes, assessment of antimicrobial susceptibility and molecular epidemiology studies. Of these 994 isolates, 183 (18.4% had carbapenemase genes: 157 (15.8% KPC (145 KPC-2 and 12 KPC-17, 16 (1.6% IMP-8, 9 (0.9% VIM-1, and 1 (0.1% NDM-1. KPC had the highest prevalence rate among the carbapenemases and represented a major epidemic clone circulating in Taiwan. The ST512 and ST258 KPC-2 KPs were first identified in Taiwan and were grouped into a small cluster in the PFGE profile. In addition, the genetic structure encompassing the blaKPC gene of the ST512 and ST258 isolates showed a different pattern from that of other KPC isolates. ST11 may be a major sequence type circulating in Taiwan, although a specific minor clone has begun to be observed. This is the first report of ST258 and ST512 KPC-2 KP isolates in Taiwan, whether ST258 and ST512 will become the next endemic problems in Taiwan should be closely monitored.

  10. Coproduction of KPC-2 and QnrB19 in Klebsiella pneumoniae ST340 isolate in Brazil.

    Science.gov (United States)

    Martins, Willames M B S; Almeida, Anna C S; Nicoletti, Adriana G; Cayô, Rodrigo; Gales, Ana C; Alves, Luiz C; Brayner, Fábio B; Vilela, Marinalda A; Morais, Márcia M C

    2015-12-01

    Few reports described the presence of bla(KPC) and qnr genes in the same isolate. This study reports the combination of bla(KPC-2) and qnrB19 genes in Klebsiella pneumoniae ST340 isolate in Brazil. These findings draw attention to this combination in ST340 isolate, which is part of the CC258, disseminated in Latin America.

  11. Complete Genome Sequence of KPC-3- and CTX-M-15-Producing Klebsiella pneumoniae Sequence Type 307.

    Science.gov (United States)

    Villa, Laura; Feudi, Claudia; Fortini, Daniela; Iacono, Michele; Bonura, Celestino; Endimiani, Andrea; Mammina, Caterina; Carattoli, Alessandra

    2016-04-07

    Klebsiella pneumoniaesequence type (ST) 307, carryingblaKPC-3,blaCTX-M-15,blaOXA-1,aac(6')-Ib-cr, andqnrB1 genes, is replacing the predominant hyperepidemic ST258 clone in Italy. Whole-genome and complete plasmid sequencing of one ST307 strain was performed and new features were identified.

  12. Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece : a close call

    NARCIS (Netherlands)

    Bathoorn, E.; Tsioutis, C.; Voorham, J. M. da Silva; Scoulica, E. V.; Ioannidou, E.; Zhou, K.; Rossen, J. W.; Gikas, A.; Friedrich, A. W.; Grundmann, H.

    2016-01-01

    Molecular resistance markers for pan-resistant isolates of KPC-producing Klebsiella pneumoniae were identified and showed core-genome MLST to be a promising tool for tracking outbreaks and transmission pathways.KPC-2-producing Klebsiella pneumoniae (KPC-KP) ST258 has been rapidly expanding and is of

  13. Student-Athletes' Misperceptions of Male and Female Peer Drinking Norms: A Multi-Site Investigation of the "Reign of Error"

    Science.gov (United States)

    Perkins, H. Wesley; Craig, David W.

    2012-01-01

    Data from student-athletes at 15 colleges and universities (N = 4,258) document extensive misperceptions of peer drinking norms and their association with personal quantity of alcohol consumed. Regardless of actual drinking norms at each school, student-athletes commonly overestimated the alcohol consumption norms (both quantity and frequency…

  14. Observations of Adolescent Peer Group Interactions as a Function of Within- and Between-Group Centrality Status

    Science.gov (United States)

    Ellis, Wendy E.; Dumas, Tara M.; Mahdy, Jasmine C.; Wolfe, David A.

    2012-01-01

    Observations of adolescent (n = 258; M age = 15.45) peer group triads (n = 86) were analyzed to identify conversation and interaction styles as a function of within-group and between-group centrality status. Group members' discussions about hypothetical dilemmas were coded for agreements, disagreements, commands, and opinions. Interactions during…

  15. SAJOG 675.indd

    African Journals Online (AJOL)

    IOL is defined as a process of artificial stimulation of uterine contractions after the fetus is .... Vacuum. 3. 0. 2. 5. Total. 258. 236. 8. 502. Indications for CS, n .... without saline infusion, rupture of the membranes, and mechanical dilators such as ...

  16. Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece : a close call

    NARCIS (Netherlands)

    Bathoorn, E.; Tsioutis, C.; Da Silva-Voorham, Júlia; Scoulica, E. V.; Ioannidou, E.; Zhou, K.; Rossen, J. W.; Gikas, A.; Friedrich, A. W.; Grundmann, H.

    Molecular resistance markers for pan-resistant isolates of KPC-producing Klebsiella pneumoniae were identified and showed core-genome MLST to be a promising tool for tracking outbreaks and transmission pathways.KPC-2-producing Klebsiella pneumoniae (KPC-KP) ST258 has been rapidly expanding and is

  17. Anxiety, depression, and perception of early parenting: A meta-analysis. Erratum

    NARCIS (Netherlands)

    Gerlsma, C.; Emmelkamp, P.M.G.; Arrindell, W.A.

    1991-01-01

    Reports an error in the original article by C. Gerlsma et al (Clinical Psychology Review, 1990, Vol 10[3], 251-277). Corrections are made to the 1st and 3rd formulas on page 257 and to Table 1, page 258, and Table 1, page 261."

  18. Domain Modeling: NP_067072.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_067072.3 chr14 The crystal structure of the BAR domain from human Bin1/Amphiphys...in II and its implications for molecular recognition p2ficb_ chr14/NP_067072.3/NP_067072.3_holo_90-290.pdb swppa 257F,258R,261L _XE 0 ...

  19. Drug: D00428 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 258.2262 D00428.gif Analgesic; Anti-inflammatory [DS:H00445 H00630] ATC code: N02BA06 Indications: Rheumatoid arthritis, Osteoarthrit...is, etc. cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509]; cyclooxygenase-

  20. Forecasting the Supply of Women Available to the Navy.

    Science.gov (United States)

    1980-08-01

    Endocrine System Diseases 240-258 Diabetes Mellitus 250 Other Metabolic Diseases and Avitaminoses 260-279 Blood and Blood-Forming Organ Diseases 280-289...600-607 (Nonvenereal) and Breast 610-611 eExlude Pterygium (372) fExclude Hypertrophy of Tonsils and Adenoids (500) gExclude Periodontal Diseases (523

  1. The Battle of Warsaw, 1920: Impact on Operational Thought

    Science.gov (United States)

    1994-05-06

    Poles believed earnestly that they were fighting for the most sacred possessions of man: freedom, language, traditions, and religion .4 2 SECTION IV THE...York: St. Martin’s Press, 1972.) p. 51. Quoted from, Historia Polski, Vol. IV, Pt 1. Warsaw (1966), p. 258. 7 J.F.C. Fuller, A Military History of the

  2. Sexy versus Strong: What Girls and Women Think of Female Athletes

    Science.gov (United States)

    Daniels, Elizabeth A.

    2012-01-01

    Little research has investigated girls' and college women's reactions to non-objectified media images of women, including those that depict women in instrumental activities like playing a sport. This study examined open-ended responses to images of performance athletes, sexualized athletes, and sexualized models. Participants were 258 adolescent…

  3. How Much Do Parents Think They Talk to Their Child?

    Science.gov (United States)

    Richards, Jeffrey A.; Gilkerson, Jill; Xu, Dongxin; Topping, Keith

    2017-01-01

    This study investigated whether parent perceptions of their own and their child's levels of talkativeness were related to objective measures recorded via the Language Environment Analysis (LENA) System. Parents of 258 children aged 7 to 60 months completed a questionnaire on which they rated how much they and their child talked. Six months…

  4. Synthesis and biological activity of new 1,8-diaza-2,9,10-anthracenetrione derivatives.

    Science.gov (United States)

    Gesto, C; de la Cuesta, E; Avendaño, C; Emling, F

    1992-08-01

    Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.

  5. A Strategy to Reduce Plagiarism in an Undergraduate Course

    Science.gov (United States)

    Belter, Ronald W.; du Pre, Athena

    2009-01-01

    This study evaluated how effective an online academic integrity module was at reducing the occurrence of plagiarism in a written assignment for a university course. In a preintervention comparison group, plagiarism was detected in 25.8% of papers submitted, compared with only 6.5% in the group that completed the academic integrity module. The…

  6. A new regime of the Agulhas Current Retroflection: Turbulent Choking of Indian-Atlantic leakag

    NARCIS (Netherlands)

    le Bars, D.L.B.; de Ruijter, W.P.M.; Dijkstra, H.A.

    2012-01-01

    An analysis of the Indian Ocean circulation and the Agulhas Current retroflection is carried out using a primitive equation model with simplified coastline and flat bottom. Four configurations with 0.258 and 0.18 horizontal resolution and in barotropic and baroclinic cases are considered. The wind s

  7. 27 CFR 479.85 - Identification of transferee.

    Science.gov (United States)

    2010-04-01

    ... applicant 2 × 2 inches in size, clearly showing a full front view of the features of the applicant with head... shall attach two properly completed FBI Forms FD-258 (Fingerprint Card) to the application. The fingerprints must be clear for accurate classification and should be taken by someone properly equipped to...

  8. 27 CFR 479.63 - Identification of applicant.

    Science.gov (United States)

    2010-04-01

    ... inches in size, clearly showing a full front view of the features of the applicant with head bare, with... properly completed FBI Forms FD-258 (Fingerprint Card) to the application. The fingerprints must be clear... state that the certifying official is satisfied that the fingerprints and photograph accompanying...

  9. At the European Hybrid Spectrometer (EHS) for the experiment NA27

    CERN Multimedia

    1983-01-01

    Continuing along the beam H2 downstream of the Forward Cerenkov (FC, photo 8311661X) one finds the Transition Radiation Detector (TRD) and the Forward Gamma Detector (FGD, yellow structure, near bottom). See Nucl. Instrum. Methods A258 (1987) 26-50.

  10. America's Star Libraries, 2010: Top-Rated Libraries

    Science.gov (United States)

    Lyons, Ray; Lance, Keith Curry

    2010-01-01

    The "LJ" Index of Public Library Service 2010, "Library Journal"'s national rating of public libraries, identifies 258 "star" libraries. Created by Ray Lyons and Keith Curry Lance, and based on 2008 data from the IMLS, it rates 7,407 public libraries. The top libraries in each group get five, four, or three stars. All included libraries, stars or…

  11. America's Star Libraries: Top-Rated Libraries

    Science.gov (United States)

    Lance, Keith Curry; Lyons, Ray

    2009-01-01

    "Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

  12. Investigation of medical board reports of disability due to mental health problems

    Directory of Open Access Journals (Sweden)

    Mesut Yildiz

    2016-06-01

    Conclusion: We think that this report might be helpful for regulations related to disabled people, and might guide adult psychiatric services for patients who present to medical boards for disability due to mental health problems. [Cukurova Med J 2016; 41(2.000: 253-258

  13. Presentation of chronic daily headache : A clinical study

    NARCIS (Netherlands)

    Spierings, E L H; Schroevers, M.; Honkoop, P.C.; Sorbi, M.

    1998-01-01

    We studied the presentation of chronic daily headache in 258 patients from a private headache practice, 50 men and 208 women. Chronic daily headache was defined as headaches, occurring at least 5 days per week for at least 1 year. Seventy-seven percent of the patients experienced the onset of headac

  14. Development of chronic daily headache : A clinical study

    NARCIS (Netherlands)

    Spierings, E.L.H.; Schroevers, M.; Honkoop, P.C.; Sorbi, M.

    1998-01-01

    We studied the development of chronic daily headache in 258 headache practice patients, 50 men and 208 women. Chronic daily headache was defined as headaches occurring at least 5 days per week for at least 1 year. Twenty-two percent of the patients had daily headaches from the onset, and 78% initial

  15. A novel synthesis of hemispherands

    NARCIS (Netherlands)

    Ostaszewski, Ryszard; Verboom, Willem; Reinhoudt, David N.

    1992-01-01

    A novel, flexible synthesis of hemispherands {2,5,8-trioxa[9](3,3″) m-terphenylophanes 5a-d} with different central aromatic groups is described. The key step comprises the introduction of the central aromatic ring in the last step of the synthesis via a Suzuki cross-coupling reaction using palladiu

  16. AcEST: DK960119 [AcEST

    Lifescience Database Archive (English)

    Full Text Available V + + +Q+++QL+D ++ + Sbjct: 258 SEDVITDIAGVIPAATIDGIFTACHSGSFDKLEAVVKNLIDEGHAATQLVNQLHDAIIEN 317 Query: 181 EELSDTQKAQICERI...EKIDGVFAACQSGSFDKLEAVVKDLIDEGHAATQLVNQLHDVVV-ENNLS 320 Query: 193 DTQKAQICERIAQADKCLIDGADEYLQMLDVASGTMR 303 ...QGYPVSQVISQLFDYVLTT 289 Query: 181 EELSDTQKAQICERIAQADKCLIDGADEYLQMLDVASGTMRSFCN 315 ++L+ +QK+ I +I D+ LIDG+...+E L Sbjct: 241 SVEELAGAVPYNIIRSLLDTAYTKNVSNIETLSRDVAAEGYSTGIILSQLHDVLLKEETL 300 Query: 190 SDTQKAQICERIAQAD...SDALFPKSAAKSIRYNEIAKVVENMIAEGWSASQTVSQLY 359 Query: 163 DVVVPDEELSDTQKAQICERIAQADKCLIDGADEYLQMLDV 285 + V+ D

  17. Data of evolutionary structure change: 1CERO-3CIFB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CERO-3CIFB 1CER 3CIF O B -MKVGINGFGRIGRQVFRILHSRG-VEVALINDLT-DNK...line> ALA CA 375 LEU CA 455 3CIF ...B 3CIFB CMERNDITVVALEU CA 389 3CIF B 3CIF...94 ARG CA 258 ARG CA 299 ALA CA 245 3CIF

  18. Data of evolutionary structure change: 1GADO-3CIFD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1GADO-3CIFD 1GAD 3CIF O D TIKVGINGFGRIGRIVFRAAQKRSDIEIVAINDLL-DAD...ine> ASP CA 257 TYR CA 259 MET CA 367 3CIF... D 3CIFD ...n> 3CIF D 3CIFD NTEY...01 TRP CA 190 ARG CA 258 GLY CA 288 3CIF

  19. Coping with Career Indecision: Differences between Four Career Choice Types

    Science.gov (United States)

    Lee, Ki-Hak

    2005-01-01

    This study examined the applicability of Gianakos' [1999. Journal of Vocational Behavior, 54, 244-258] typology of career choice--stable, conventional, multiple-trial and unstable--to emotional coping with career indecision. Three hundred-twenty (Men = 203, Women = 117) Korean undergraduates were classified into Gianakos' four career choice types.…

  20. Butyltins in the sediments of Kochi and Mumbai harbours, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Bhosle, N.B.; Garg, A.; Harji, R.; Jadhav, S.; Sawant, S.S.; Krishnamurthy, V.; Anil, A.C.

    ;258:99–102. Amouroux D, Tessier E, Donard OFX. Volatilization of organotin compounds from estuarine and coastal environments. Environ Sci Technol 2000;34: 988–95. Arnold A, Weidenhaupt MM, David SR, Muller SB, Haderlein S, Schwarzen- bach RP. Aqueous speciation and 1...

  1. Lake Tahoe--A Bibliography. Its History, Natural History and Travel Guides.

    Science.gov (United States)

    Trimm, Maureen, Comp.

    The Lake Tahoe region of California and Nevada is an area that is under intensive federal, state, regional, and local study. This bibliography is a selective listing of 258 monographs and 58 maps which will assist scholars in obtaining a historical perspective of the region. The monographs are arranged alphabetically by author, followed by title,…

  2. Convergence, Admissibility, and Fit of Alternative Confirmatory Factor Analysis Models for MTMM Data

    Science.gov (United States)

    Lance, Charles E.; Fan, Yi

    2016-01-01

    We compared six different analytic models for multitrait-multimethod (MTMM) data in terms of convergence, admissibility, and model fit to 258 samples of previously reported data. Two well-known models, the correlated trait-correlated method (CTCM) and the correlated trait-correlated uniqueness (CTCU) models, were fit for reference purposes in…

  3. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... a patient's and family's experience with illness. Category Science & Technology License Standard YouTube License Show more Show ... Young Adult Cancer Program - Duration: 11:08. UCLA Health 220,258 views 11:08 End of Life ...

  4. Book reviews

    NARCIS (Netherlands)

    NN,

    1962-01-01

    Nature Conservation in western Malaysia, 1961. Edited by J. wyatt-Smith & P.R. Wycherley. An issue to mark the occasion of the 21st anniversary of the founding of the Malayan Nature Society 1940-1961. viii + 258 pp., 44 plates, maps. There is all reason to congratulate the Malayan Nature Society wit

  5. Effects of Prostate Cancer Screening and Treatment

    NARCIS (Netherlands)

    E.M. Wever (Elisabeth)

    2012-01-01

    textabstractProstate cancer is the second most frequently diagnosed cancer of men worldwide. The number of new cases worldwide was estimated at 899,000 and accounted for 13.6% of all cancers in men in 2008. With an estimated 258,000 deaths in 2008, prostate cancer is the sixth leading cause of death

  6. High Technology Mass Spectrometry Laboratory

    Science.gov (United States)

    2010-08-01

    Corbett, F.W. Benz and R.S. Doyle. Acrylonitrile induces autolysis Bacillus subtilis. FEMS Microbiology Letters 182: 255-258 (2000). 25. Nerland, D.E., J...Supplement, 391 (1999). 24. Benz, F.W., J Li, D Corbett, T.S. Chen and D E Nerland. Neither Direct Chemical Nor Cyanide Antagonism Can Fully Explain The

  7. Domain Modeling: NP_954871.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_954871.1 chr17 Solution structure of three tandem repeats of zf-C2H2 domains fro...m human Kruppel-like factor 5 p2ebta_ chr17/NP_954871.1/NP_954871.1_holo_244-338.pdb blast 256C,258I,261C,26

  8. Human prominin-1 (CD133) is detected in both neoplastic and non-neoplastic salivary gland diseases and released into saliva in a ubiquitinated form.

    Science.gov (United States)

    Karbanová, Jana; Laco, Jan; Marzesco, Anne-Marie; Janich, Peggy; Voborníková, Magda; Mokrý, Jaroslav; Fargeas, Christine A; Huttner, Wieland B; Corbeil, Denis

    2014-01-01

    Prominin-1 (CD133) is physiologically expressed at the apical membranes of secretory (serous and mucous) and duct cells of major salivary glands. We investigated its expression in various human salivary gland lesions using two distinct anti-prominin-1 monoclonal antibodies (80B258 and AC133) applied on paraffin-embedded sections and characterized its occurrence in saliva. The 80B258 epitope was extensively expressed in adenoid cystic carcinoma, in lesser extent in acinic cell carcinoma and pleomorphic adenoma, and rarely in mucoepidermoid carcinoma. The 80B258 immunoreactivity was predominately detected at the apical membrane of tumor cells showing acinar or intercalated duct cell differentiation, which lined duct- or cyst-like structures, and in luminal secretions. It was observed on the whole cell membrane in non-luminal structures present in the vicinity of thin-walled blood vessels and hemorrhagic areas in adenoid cystic carcinoma. Of note, AC133 labeled only a subset of 80B258-positive structures. In peritumoral salivary gland tissues as well as in obstructive sialadenitis, an up-regulation of prominin-1 (both 80B258 and AC133 immunoreactivities) was observed in intercalated duct cells. In most tissues, prominin-1 was partially co-expressed with two cancer markers: carcinoembryonic antigen (CEA) and mucin-1 (MUC1). Differential centrifugation of saliva followed by immunoblotting indicated that all three markers were released in association with small membrane vesicles. Immuno-isolated prominin-1-positive vesicles contained CEA and MUC1, but also exosome-related proteins CD63, flotillin-1, flotillin-2 and the adaptor protein syntenin-1. The latter protein was shown to interact with prominin-1 as demonstrated by its co-immunoisolation. A fraction of saliva-associated prominin-1 appeared to be ubiquitinated. Collectively, our findings bring new insights into the biochemistry and trafficking of prominin-1 as well as its immunohistochemical profile in certain types

  9. Human prominin-1 (CD133 is detected in both neoplastic and non-neoplastic salivary gland diseases and released into saliva in a ubiquitinated form.

    Directory of Open Access Journals (Sweden)

    Jana Karbanová

    Full Text Available Prominin-1 (CD133 is physiologically expressed at the apical membranes of secretory (serous and mucous and duct cells of major salivary glands. We investigated its expression in various human salivary gland lesions using two distinct anti-prominin-1 monoclonal antibodies (80B258 and AC133 applied on paraffin-embedded sections and characterized its occurrence in saliva. The 80B258 epitope was extensively expressed in adenoid cystic carcinoma, in lesser extent in acinic cell carcinoma and pleomorphic adenoma, and rarely in mucoepidermoid carcinoma. The 80B258 immunoreactivity was predominately detected at the apical membrane of tumor cells showing acinar or intercalated duct cell differentiation, which lined duct- or cyst-like structures, and in luminal secretions. It was observed on the whole cell membrane in non-luminal structures present in the vicinity of thin-walled blood vessels and hemorrhagic areas in adenoid cystic carcinoma. Of note, AC133 labeled only a subset of 80B258-positive structures. In peritumoral salivary gland tissues as well as in obstructive sialadenitis, an up-regulation of prominin-1 (both 80B258 and AC133 immunoreactivities was observed in intercalated duct cells. In most tissues, prominin-1 was partially co-expressed with two cancer markers: carcinoembryonic antigen (CEA and mucin-1 (MUC1. Differential centrifugation of saliva followed by immunoblotting indicated that all three markers were released in association with small membrane vesicles. Immuno-isolated prominin-1-positive vesicles contained CEA and MUC1, but also exosome-related proteins CD63, flotillin-1, flotillin-2 and the adaptor protein syntenin-1. The latter protein was shown to interact with prominin-1 as demonstrated by its co-immunoisolation. A fraction of saliva-associated prominin-1 appeared to be ubiquitinated. Collectively, our findings bring new insights into the biochemistry and trafficking of prominin-1 as well as its immunohistochemical profile in

  10. Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing

    Science.gov (United States)

    Stoesser, Nicole; Sheppard, Anna E.; Pankhurst, Louise; Giess, Adam; Yeh, Anthony J.; Didelot, Xavier; Turner, Stephen D.; Sebra, Robert; Kasarskis, Andrew; Peto, Tim; Crook, Derrick; Sifri, Costi D.

    2015-01-01

    The global emergence of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) multilocus sequence type ST258 is widely recognized. Less is known about the molecular and epidemiological details of non-ST258 K. pneumoniae in the setting of an outbreak mediated by an endemic plasmid. We describe the interplay of blaKPC plasmids and K. pneumoniae strains and their relationship to the location of acquisition in a U.S. health care institution. Whole-genome sequencing (WGS) analysis was applied to KPC-Kp clinical isolates collected from a single institution over 5 years following the introduction of blaKPC in August 2007, as well as two plasmid transformants. KPC-Kp from 37 patients yielded 16 distinct sequence types (STs). Two novel conjugative blaKPC plasmids (pKPC_UVA01 and pKPC_UVA02), carried by the hospital index case, accounted for the presence of blaKPC in 21/37 (57%) subsequent cases. Thirteen (35%) isolates represented an emergent lineage, ST941, which contained pKPC_UVA01 in 5/13 (38%) and pKPC_UVA02 in 6/13 (46%) cases. Seven (19%) isolates were the epidemic KPC-Kp strain, ST258, mostly imported from elsewhere and not carrying pKPC_UVA01 or pKPC_UVA02. Using WGS-based analysis of clinical isolates and plasmid transformants, we demonstrate the unexpected dispersal of blaKPC to many non-ST258 lineages in a hospital through spread of at least two novel blaKPC plasmids. In contrast, ST258 KPC-Kp was imported into the institution on numerous occasions, with other blaKPC plasmid vectors and without sustained transmission. Instead, a newly recognized KPC-Kp strain, ST941, became associated with both novel blaKPC plasmids and spread locally, making it a future candidate for clinical persistence and dissemination. PMID:25561339

  11. Chemical looping of metal nitride catalysts: low-pressure ammonia synthesis for energy storageElectronic supplementary information (ESI) available: Experimental and computational details, free energy plots for the NH3 evolution and N2 reduction with Co3N/Co, Fe4N/Fe, Mn5N2/Mn4N, Mo2N/Mo, CrN/Cr2N, TaN/Ta2N, NbN/Nb2N, Li3N/LiH, Ba3N2/BaH2, Sr3N2/SrH2, and Ca3N2/CaH2, surface oxidation energetics, ΔGvac[NHx, yH] based on gas phase H2 as hydrogen source, NH3 evolution with Fe-doped Mn4N, NH3 evolution with Mn6N2.58, Ca3N2 and Sr2N after correcting for partial nitride hydrolysis, NH3 yield from Ca3N2vs. time and H2 gas flow rate. See DOI: 10.1039/c5sc00789e

    National Research Council Canada - National Science Library

    Michalsky, R; Avram, A. M; Peterson, B. A; Pfromm, P. H; Peterson, A. A

    2015-01-01

    .... We demonstrate how ammonia can be produced at ambient pressure from air, water, and concentrated sunlight as renewable source of process heat via nitrogen reduction with a looped metal nitride...

  12. Developments for transactinide chemistry experiments behind the gas-filled separator TASCA

    Energy Technology Data Exchange (ETDEWEB)

    Even, Julia

    2011-12-13

    synthesised carbonyl complexes were identified by nuclear decay spectroscopy. Some complexes were studied with isothermal chromatography or thermochromatography methods. The chromatograms were compared with Monte Carlo Simulations to determine the adsorption enthalpyrnon silicon dioxide and on gold. These simulations based on existing codes, that were modified for the different geometries of the chromatography channels. All observed adsorption enthalpies (on silcon oxide as well as on gold) are typical for physisorption. Additionally, the thermalstability of some of the carbonyl complexes was studied. This showed that at temperatures above 200 C therncomplexes start to decompose. It was demonstrated that carbonyl-complex chemistry is a suitable method to study rutherfordium, dubnium, seaborgium, bohrium, hassium, and meitnerium. Until now, only very simple, thermally stable compounds have been synthesized in the gas-phase chemistry of the transactindes. With the synthesis of transactinide-carbonyl complexes a new compound class would be discovered. Transactinide chemistry would reach the border between inorganic and metallorganic chemistry. Furthermore, the in-situ synthesised carbonyl complexes would allow nuclear spectroscopy studies under low background conditions making use of chemically prepared samples. [German] Die vorliegende Arbeit befasst sich mit der Entwicklung von Experimenten hinter dem gasgefuellten Separator TASCA (TransActinide Separator and Chemistry Apparatus) zur Studie des chemischen Verhaltens der Transactinide. Zum einen wurde die Moeglichkeit der elektrochemischen Abscheidung kurzlebiger Isotope der Elemente Ruthenium und Osmium auf Goldelektroden im Hinblick auf ein Experiment mit Hassium untersucht. Aus der Literatur ist bekannt, dass bei der elektrochemischen Abscheidung einzelner Atome das Abscheidepotential signifikant vom Nernst-Potential abweicht. Die Verschiebung des Potentials haengt von der Adsorptionsenthalpie des abzuscheidenden Elements

  13. Low completion rate of hepatitis B vaccination in female sex workers.

    Science.gov (United States)

    Magalhães, Rosilane de Lima Brito; Teles, Sheila Araújo; Reis, Renata Karina; Galvão, Marli Teresinha Gimeniz; Gir, Elucir

    2017-01-01

    to assess predictive factors for noncompletion of the hepatitis B vaccination schedule in female sex workers in the city of Teresina, Northeastern Brazil. 402 women were interviewed and, for those who did not wish to visit specialized sites, or did not know their hepatitis B vaccination status, the vaccine was offered at their workplaces. Bi- and multivariate analyses were performed to identify potential predictors for noncompletion of the vaccination schedule. of the 284 women eligible for vaccination, 258 (90.8%) received the second dose, 157/258 (60.8%) and 68/258 (26.3%) received the second and third doses, respectively. Working at clubs and consuming illicit drugs were predictors for noncompletion of the vaccination schedule. the high acceptability of the vaccine's first dose, associated with low completion rates of the vaccination schedule in sex workers, shows the need for more persuasive strategies that go beyond offering the vaccine at their workplaces. avaliar fatores preditores de não completude do esquema vacinal contra hepatite B em mulheres que se prostituem em Teresina, Nordeste do Brasil. Um total de 402 mulheres foi entrevistado e, para as que se negaram a irem a lugares especializados, ou desconheciam sua situação vacinal contra hepatite B, a vacina foi oferecida no local do trabalho. Análises bi e multivariadas foram realizadas para identificar potenciais preditores de não completude do esquema vacinal. Das 284 mulheres elegíveis para vacinação, 258 (90,8%) receberam a primeira dose, 157/258 (60,8%) e 68/258 (26,3%) receberam a segunda e terceira doses. Trabalhar em boates e consumir drogas ilícitas foram preditores de não completude do esquema vacinal (p<0,05). A elevada aceitabilidade da primeira dose da vacina, associada à baixa completude do esquema vacinal em profissionais do sexo, evidencia a necessidade de estratégia mais persuasiva que vá além da oferta da vacina no local de trabalho.

  14. Observation of $e^{+}e^{-} \\to \\eta^{\\prime} J/\\psi$ at center-of-mass energies between 4.189 and 4.600 GeV

    CERN Document Server

    Ablikim, M; Ahmed, S; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; Amoroso, A; An, F F; An, Q; Bai, J Z; Ferroli, R Baldini; Ban, Y; Bennett, D W; Bennett, J V; Berger, N; Bertani, M; Bettoni, D; Bian, J M; Bianchi, F; Boger, E; Boyko, I; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, H Y; Chen, J C; Chen, M L; Chen, S; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Cibinetto, G; Dai, H L; Dai, J P; Dbeyssi, A; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; De Mori, F; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Dou, Z L; Du, S X; Duan, P F; Fan, J Z; Fang, J; Fang, S S; Fang, X; Fang, Y; Farinelli, R; Fava, L; Fedorov, O; Feldbauer, F; Felici, G; Feng, C Q; Fioravanti, E; Fritsch, M; Fu, C D; Gao, Q; Gao, X L; Gao, X Y; Gao, Y; Gao, Z; Garzia, I; Goetzen, K; Gong, L; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, R P; Guo, Y; Guo, Y P; Haddadi, Z; Hafner, A; Han, S; Hao, X Q; Harris, F A; He, K L; Heinsius, F H; Held, T; Heng, Y K; Holtmann, T; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Hu, Y; Huang, G S; Huang, J S; Huang, X T; Huang, X Z; Huang, Y; Huang, Z L; Hussain, T; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L W; Jiang, X S; Jiang, X Y; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Julin, A; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Ke, B C; Kiese, P; Kliemt, R; Kloss, B; Kolcu, O B; Kopf, B; Kornicer, M; Kupsc, A; Kühn, W; Lange, J S; Lara, M; Larin, P; Leithoff, H; Leng, C; Li, C; Li, Cheng; Li, D M; Li, F; Li, F Y; Li, G; Li, H B; Li, H J; Li, J C; Li, Jin; Li, K; Li, K; Li, Lei; Li, P R; Li, Q Y; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Y B; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Lin, D X; Liu, B; Liu, B J; Liu, C X; Liu, D; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, J Y; Liu, K; Liu, K Y; Liu, L D; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Y Y; Liu, Z A; Liu, Zhiqing; Loehner, H; Lou, X C; Lu, H J; Lu, J G; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lyu, X R; Ma, F C; Ma, H L; Ma, L L; Ma, M M; Ma, Q M; Ma, T; Ma, X N; Ma, X Y; Ma, Y M; Maas, F E; Maggiora, M; Mao, Y J; Mao, Z P; Marcello, S; Messchendorp, J G; Mezzadri, G; Min, J; Mitchell, R E; Mo, X H; Mo, Y J; Morales, C Morales; Muchnoi, N Yu; Muramatsu, H; Musiol, P; Nefedov, Y; Nerling, F; Nikolaev, I B; Ning, Z; Nisar, S; Niu, S L; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pan, Y; Patteri, P; Pelizaeus, M; Peng, H P; Peters, K; Pettersson, J; Ping, J L; Ping, R G; Poling, R; Prasad, V; Qi, H R; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, N; Qin, X S; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Rosner, Ch; Ruan, X D; Sarantsev, A; Savri, M; Schnier, C; Schoenning, K; Schumann, S; Shan, W; Shao, M; Shen, C P; Shen, P X; Shen, X Y; Sheng, H Y; Shi, M; Song, W M; Song, X Y; Sosio, S; Spataro, S; Sun, G X; Sun, J F; Sun, S S; Sun, X H; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Tiemens, M; Uman, I; Varner, G S; Wang, B; Wang, B L; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, S G; Wang, W; Wang, W P; Wang, X F; Wang, Y; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Wang, Z Y; Weber, T; Wei, D H; Wei, J B; Weidenkaff, P; Wen, S P; Wiedner, U; Wolke, M; Wu, L H; Wu, L J; Wu, Z; Xia, L; Xia, L G; Xia, Y; Xiao, D; Xiao, H; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, J J; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H J; Yang, H X; Yang, L; Yang, Y X; Ye, M; Ye, M H; Yin, J H; Yu, B X; Yu, C X; Yu, J S; Yuan, C Z; Yuan, W L; Yuan, Y; Yuncu, A; Zafar, A A; Zallo, A; Zeng, Y; Zeng, Z; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J; Zhang, J J; Zhang, J L; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, K; Zhang, L; Zhang, S Q; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y N; Zhang, Y T; Zhang, Yu; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, J Y; Zhao, J Z; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, W J; Zheng, Y H; Zhong, B; Zhou, L; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, S; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zotti, L; Zou, B S; Zou, J H

    2016-01-01

    The process $e^{+}e^{-}\\to \\eta^{\\prime} J/\\psi$ is observed for the first time with a statistical significance of $8.6\\sigma$ at center-of-mass energy $\\sqrt{s} = 4.226$ GeV and $7.3\\sigma$ at $\\sqrt{s} = 4.258$ GeV using data samples collected with the BESIII detector. The Born cross sections are measured to be $(3.7 \\pm 0.7 \\pm 0.3)$ and $(3.9 \\pm 0.8 \\pm 0.3)$ pb at $\\sqrt{s} = 4.226$ and $4.258$ GeV, respectively, where the first errors are statistical and the second systematic. Upper limits at the 90% confidence level of the Born cross sections are also reported at other 12 energy points.

  15. In vivo multiclonal transfer of bla(KPC-3) from Klebsiella pneumoniae to Escherichia coli in surgery patients.

    Science.gov (United States)

    Gona, F; Barbera, F; Pasquariello, A C; Grossi, P; Gridelli, B; Mezzatesta, M L; Caio, C; Stefani, S; Conaldi, P G

    2014-10-01

    During active surveillance at the Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT, Palermo, Italy) with the CARBA screening medium, five pairs of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae and Escherichia coli strains were isolated in each of five colonized patients. In each patient, lateral gene transfer was demonstrated by comparing K. pneumoniae and E. coli strains, both possessing KPC-3, Tn4401a and pKpQIL-IT elements. The isolates were found to be multiclonal by multilocus sequence typing (sequence type (ST) 512 related to ST258, and ST307 belonging to a clonal complex different from the habitual sequence clone ST258 isolated in Italy) and pulsed-field gel electrophoresis. The results of our study highlight the easy transfer of KPC among Enterobacteriaceae colonizing the human intestine, and the active and careful surveillance required to identify and prevent the spread of these multidrug-resistant microorganisms.

  16. Effects of a Behavioral and Exercise Program on Depression and Quality of Life in Community-Dwelling Older Adults: A Controlled, Quasi-Experimental Study.

    Science.gov (United States)

    Azizan, Azilyana; Justine, Maria

    2016-02-01

    Sedentary behavior and low participation in exercise among older adults can lead to depression and low quality of life (QOL). The current study investigated the effects of behavioral and exercise programs on depression severity and QOL among Malaysian community-dwelling older adults. A controlled, quasi-experimental, pre-posttest design was used. A total of 63 participants were divided into three groups: (a) exercise and behavior group (EBG), (b) exercise only group (EG), and (c) control group (CG). Results showed a significant difference in depression among groups (F(2,58) = 33.49, p EG > CG) and mental (F(2,58) = 4.08, p CG > EG) scores of QOL. A combination of behavioral and exercise programs has superior effects on depression and QOL of older adults. [Journal of Gerontological Nursing, 42(2), 45-54.].

  17. 整胸寡节瓢虫形态特征及生物学特性研究%The Research of Telsimia emarginata Chapin Morphological and Biology Characteristics

    Institute of Scientific and Technical Information of China (English)

    黄翠琴

    2014-01-01

    Telsimia emarginata Chapin is a kind of important natural enemy insects hunting scale in the bamboo forest, six generations a year in Fujian. Female insects laying. Most eggs in June, each female insect biggest spawning 258 grains. Both adult and larvae can prey Kuwanaspis vermiformis, it’s a kind of the development value extremely natural enemy insects which prey on scale insect.%整胸寡节瓢虫(Telsimia emarginata Chapin)是竹林里的一种重要食蚧天敌昆虫,在福建1年发生6代。雌虫于6—7月产卵量最大,单雌最大产卵量达258粒。成虫和幼虫均能捕食蠕须盾蚧,是一种极具开发价值的食蚧天敌昆虫。

  18. 小肌肉学习对孤独症谱系障碍儿童的康复效果%Effect of Small Muscle Learning on Children with Autism Spectrum Disorders

    Institute of Scientific and Technical Information of China (English)

    李明娣; 魏来; 顾琴

    2016-01-01

    Objective To investigate the effect of small muscle learning on children with autism spectrum disorders (ASD). Methods From August, 2014 to June, 2015, 40 children of three to six years old with ASD were randomly divided into experimental group (n=20) and control group (n=20). Both groups accepted structured teaching, while the experimental group accepted small muscle learning in addition. They were assessed with Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile Third Edition (PEP-3) before and 3 months after treatment. Results The scores of ATEC decreased after treatment (t>2.025, P2.026, P2.258, P2.025, P2.026, P2.258, P<0.05)。结论 ASD患者进行小肌肉学习能进一步促进认知、语言和运动功能的改善。

  19. Measurement of the 208Pb(52Cr, n)259Sg Excitation Function

    Energy Technology Data Exchange (ETDEWEB)

    Folden III, C.M.; Dragojevic, I.; Dullmann, Ch.E.; Eichler, R.; Garcia, M.A.; Gates, J.M.; Nelson, S.L.; Sudowe, R.; Gregorich, K.E.; Hoffman, D.C.; Nitsche, H.

    2010-03-19

    The excitation function for the 208Pb(52Cr, n)259Sg reaction has been measured using the Berkeley Gas-filled Separator at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron. The maximum cross section of pb is observed at a center-of-target laboratory-frame energy of 253.0 MeV. In total, 25 decay chains originating from 259Sg were observed and the measured decay properties are in good agreement with previous reports. In addition, a partial excitation function for the 208Pb(52Cr, 2n)258Sg reaction was obtained, and an improved 258Sg half-life of ms was calculated by combining all available experimental data.

  20. 基于利率的期限结构模型的债券价格过程的分形性质%Fractal Property of the Bond-price Process in Term Structure Models for Interest Rates

    Institute of Scientific and Technical Information of China (English)

    余东; 张娜

    2010-01-01

    In this paper,we study the bond-price process in the term structure model of interest rates proposed by Ref.[4](KENNEDY D P.The term structure of interest rates as a Gaussian ran dom field[J].Mathematical Finance,1994,4(3):247-258)and obtain that the bond-price curve is a fractal with Hausdorff dimension 3/2.%本文研究了由文[4](KENNEDY D P.The term structure of interest rates as a Gaussian random field[J].Mathematical Finance,1994,4(3):247-258.)提出的利率期限结构模型下的债券价格过程,并获得了债券价格曲线是一条Hausdorff维数为3/2的分形曲线.