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Sample records for doz oblucheniya naseleniya

  1. Passive seismic tomography application for cave monitoring in DOZ underground mine PT. Freeport Indonesia

    Science.gov (United States)

    Nurhandoko, Bagus Endar B.; Wely, Woen; Setiadi, Herlan; Riyanto, Erwin

    2015-04-01

    It is already known that tomography has a great impact for analyzing and mapping unknown objects based on inversion, travel time as well as waveform inversion. Therefore, tomography has used in wide area, not only in medical but also in petroleum as well as mining. Recently, tomography method is being applied in several mining industries. A case study of tomography imaging has been carried out in DOZ ( Deep Ore Zone ) block caving mine, Tembagapura, Papua. Many researchers are undergoing to investigate the properties of DOZ cave not only outside but also inside which is unknown. Tomography takes a part for determining this objective.The sources are natural from the seismic events that caused by mining induced seismicity and rocks deformation activity, therefore it is called as passive seismic. These microseismic travel time data are processed by Simultaneous Iterative Reconstruction Technique (SIRT). The result of the inversion can be used for DOZ cave monitoring. These information must be used for identifying weak zone inside the cave. In addition, these results of tomography can be used to determine DOZ and cave information to support mine activity in PT. Freeport Indonesia.

  2. Passive seismic tomography application for cave monitoring in DOZ underground mine PT. Freeport Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Nurhandoko, Bagus Endar B.; Wely, Woen; Setiadi, Herlan [WISFIR Laboratory, Earth Physics and Complex System Division, Physics Department, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung (Indonesia); Riyanto, Erwin [Geotechnical and Hydrology PT. Freeport Indonesia wonbin-ww@hotmail.com (Indonesia)

    2015-04-16

    It is already known that tomography has a great impact for analyzing and mapping unknown objects based on inversion, travel time as well as waveform inversion. Therefore, tomography has used in wide area, not only in medical but also in petroleum as well as mining. Recently, tomography method is being applied in several mining industries. A case study of tomography imaging has been carried out in DOZ ( Deep Ore Zone ) block caving mine, Tembagapura, Papua. Many researchers are undergoing to investigate the properties of DOZ cave not only outside but also inside which is unknown. Tomography takes a part for determining this objective.The sources are natural from the seismic events that caused by mining induced seismicity and rocks deformation activity, therefore it is called as passive seismic. These microseismic travel time data are processed by Simultaneous Iterative Reconstruction Technique (SIRT). The result of the inversion can be used for DOZ cave monitoring. These information must be used for identifying weak zone inside the cave. In addition, these results of tomography can be used to determine DOZ and cave information to support mine activity in PT. Freeport Indonesia.

  3. [The use of ProstaDoz in patients with chronic prostatitis. Results ofa multicenter nonrandomized clinical study].

    Science.gov (United States)

    Kamalov, A A; Aboian, I A; Sitdykova, M È; Tsukanova, A Iu; Teodorovich, O V; Medvedev, V L; Komiakov, B K; Zhuravlev, V N; Novikov, A I; Erkovich, A A; Okhobotov, D A; Karpov, V K; Zubkov, A Iu

    2013-01-01

    The main purpose of the study was to determine the effectiveness of a multicomponent dietary supplement ProstaDoz in patients with chronic prostatitis. The study included 50 men with clinical symptoms of a chronic prostatitis, which were observed in 9 clinical centers in different regions of Russia. All patients have received 2 capsules of ProstaDoz twice a day for 1 month, followed by dynamic observation for 4 weeks. Symptomatic improvement was achieved in 46 (92%) patients. Evaluation of effects of ProstaDoz on various groups of symptoms has revealed that it reduces pain, promotes urination normalization and improvement of quality of life. These effects were maintained during all follow-up period.

  4. Documentación del fondo de Oseira (AHN relacionada con el monasterio San Pedro de Vilanova de Dozón (1015-1295

    Directory of Open Access Journals (Sweden)

    Romaní Martínez, Miguel

    2003-12-01

    Full Text Available After the introduction and the criteria for transcription, we publish 25 documents of the 11>sub>th 12th and 13thcenturies belonging to the collection of Oseira at the AHN related to the monastery of San Pedro de Vilanova de Dozon, in Tierra de Deza (Pontevedra. The suggested periods make it possible to observe the transition from the Visigothic writing to the Carolingian. We also include an appendix with tables of diplomatic and paléographie analyses, a sample of the most representative writings, onomastic and toponymie indices, and a bibliography.

    Tras la introducción y criterios de transcripción, se editan 25 documentos de los siglos XI, XII y XIII pertenecientes al fondo de Oseira del AHN relacionados con el monasterio de San Pedro de Vilanova de Dozón, en Tierra de Deza (Pontevedra. Las fechas propuestas permiten observar el paso de la escritura visigótica a la Carolina. Se incluye un apéndice con tablas de análisis diplomático y paleográfico, una muestra de las escrituras más representativas, índices onomástico y toponímico, y bibliografía.

  5. Caving performance through the integration of microseismic activity and numerical modeling at DOZ-PT Freeport, Indonesia

    Institute of Scientific and Technical Information of China (English)

    Rubio Enrique; Napitupulu Daulat

    2009-01-01

    This article describes an undergoing research at PT Freeport,Indonesia,in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed in-frastructure.At the moment,several numerical experiments have been conducted to correlate the mining activity with the microseis-mic events using the data collected during year 2005 and 2006.As a result of the preliminary analysis a micro-and a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events.Stresses have been computed us-ing standard elastic continuous boundary element models.The correlation between the average source radius and the stress perform-ance has provided a method to propose a macrocracking criterion.Several techniques have been tested to nucleate the microseismic activity around different geological features.This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts.A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model.This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismieity density.The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months.The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure.

  6. MAIN RESULTS AND WAYS TO IMPROVE THE UNIFORM STATE SYSTEM FOR POPULATION EXPOSURE DOSES CONTROL AND REGISTRATION ON THE BASIS OF STATE STATISTICAL SURVEILLANCE FORMS № 4-DOZ

    Directory of Open Access Journals (Sweden)

    A. V. Svetovidov

    2012-01-01

    Full Text Available The article gives an overview of operation results of databanks on the level and structure of the Russian Federation population exposure from natural radiation sources for the period of 2001-2010. We consider the ways to improve the system of collecting and recording of the data on the doses from natural exposure to the population based on the experience and the modern regulatory system for radiation protection.

  7. Plate-forme Magicien d'Oz pour l'\\'etude de l'apport des ACAs \\`a l'interaction

    CERN Document Server

    Simonin, Jérôme; Carbonell, Noëlle

    2007-01-01

    In order to evaluate the contribution of Embodied (Animated) Conversational Agents (ECAs) to the effectiveness and usability of human-computer interaction, we developed a software platform meant to collect usage data. This platform, which implements the wizard of Oz paradigm, makes it possible to simulate user interfaces integrating ACAs for any Windows software application. It can also save and "replay" a rich interaction trace including user and system events, screen captures, users' speech and eye fixations. This platform has been used to assess users' subjective judgements and reactions to a multimodal online help system meant to facilitate the use of software for the general public (Flash). The online help system is embodied using a 3D talking head (developed by FT R&D) which "says" oral help messages illustrated with Flash screen copies.

  8. Reconstructing the Soviet National Economic Balance, 1965 - 1984: An Alternative Approach to Estimating Soviet Military Expenditures. Volume 1. Technical Discussion

    Science.gov (United States)

    1986-03-11

    compared with input-output data for 1972 derived from Granberg (1978), Volkoy (1976), Matlin (1976), the NKh editions for 1967 and 1973 and other Soviet...Moscow: Statistika, 1979.3 Matlin , A. "Struktura Natsional’nogo Dokhoda." Voprosy Ekonomiki,I No. 9, 1976. Mayer, V. Uroven’Zluizni Naseleniya

  9. THE OUTCOMES OF FUNCTIONING OF THE UNIFIED SYSTEM OF INDIVIDUAL DOSE CONTROL OF THE RUSSIAN FEDERATION CITIZENS BASED ON THE 2015 DATA

    Directory of Open Access Journals (Sweden)

    A. N. Barkovsky

    2016-01-01

    Full Text Available The article presents the outcomes of the generalized analysis of personnel, patients, and population radiation doses information obtained from the Unified System of Individual Dose Control (USIDC for 2015. The analysis is conducted on the basis of the annual information from the forms of Federal State Statistical. Observation No.1-DOZ (personnel individual doses, No.2-DOZ (emergency doses, No.3-DOZ (patients’ exposure doses and No.4-DOZ (population exposure doses from natural and technogenically impacted background. The information is submitted by the organizations and territories accountable to the Rospotrebnadzor. The article presents a comparison with data obtained within the framework of Radiation-Hygiene passportization. In 2015, 16769 organizations providing management with artificial radiation sources submitted the form No.1-DOZ.The form No.1-DOZ contains data on 134 812 personnel individual doses, 123 404 of the personnel group A and 11 408 the personnel group B with personnel monitoring.Iin 2015,the average individual dose for the personnel group A was 1,14 mSv, the personnel group B – 0,79 mSv. In 2015, 11 720 healthcare organizations submitted the form No.3-DOZ. According to the No.3-DOZ data, more than 272 mln X-ray diagnostics were conducted in theRussian Federation in 2015. An average medical radiation dose per capita was 0,48 mSv/year and a mean medical radiation dose per an X-ray examination was 0,26 mSv. In 2015, the form No.4-DOZ contains results of 8 681 measurements of gamma dose rate in wooden houses, 12 642 measurements in one-storey stone houses, 160 174 measurements in multi-storey stone houses and 217 746 measurements on the open ground. Results of 4 441 measurements of radon concentration levels in wooden houses, 5 565 measurements in one-storey stone houses, 61 541 measurements in multi-storey stone houses are given. The population’s average effective dose from natural ionizing radiation sources amounted to 3

  10. Absisik asit (ABA) uygulamalarının domates (Lycopersicon esculentum Mill.) Fidelerinde bazı fizyolojik ve morfolojik özellikler ile kök gelişim değerlerine etkisi

    OpenAIRE

    2011-01-01

           Çalışma ile farklı doz ve sürelerde uygulanan absisik asit (ABA)'in domates (Lycopersicon esculentum Mill.) fidelerde oluşturduğu stresin; fizyolojik, morfolojik ve gelişim parametrelerine etkisi tespit edilmiş, ABA'nın domates fide yetiştiriciliğinde kullanılabilecek optimum doz ve uygulama süresi belirlenmiştir. Lycopersicon esculentum cv....

  11. THE OUTCOMES OF FUNCTIONING OF UNIFIED SYSTEM OF INDIVIDUAL DOSE CONTROL OF RUSSIAN FEDERATION CITIZENS BASED ON 2014 DATA

    Directory of Open Access Journals (Sweden)

    V. S. Repin

    2015-01-01

    Full Text Available The article presents the outcomes of the generalized analysis of personnel, patients and population radiation doses information obtained from the Unified System of Individual Dose Control (USIDC for 2014. The analysis is conducted on the basis of the annual information from the forms of Federal State Statistical Observation No.1-DOZ, No.2-DOZ, No.3-DOZ and No.4-DOZ. The information is submitted by the organizations and territories accountable to Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being – ROSPOTREBNADZOR.According to No. 1-DOZ data the total number of organizations which submitted the information about personnel dose exposure in 2014 amounted to 16424, with the total headcount of 130688 employees. The average radiation dose of group A personnel was 1,13 mSv/annum. The collective personnel radiation doze totalled 132,5 man-Sv/annum.According to No.3-DOZ data 261 mln X-ray diagnostics were conducted in Russian Federation in 2014. The average medical radiation dose per capita was 0,46 mSv/annum and collective population dose was 66883.4 man-Sv/annum. Computer tomography makes the highest contribution into collective population radiation dose (40,3% .According to the forms of statistical reporting No. 4-DOZ for 2014 in Russian Federation the population’s average effective dose from natural ionizing radiation sources amounted to 3.48 mSv/annum. The population’s annual effective radiation dose from natural sources of ionizing radiation includes about 59% of radon isotopes and progeny. In 2014 the data was submitted about job-specific doses of 5651 employees from 50 enterprises located in 18 regions of Russia. The values of job-specific radiation of these enterprises’ employees ranged between 0.01 and 3,42 mSv/annum.The article includes the Annexes with final generalized forms of Unified System of Individual Dose Control based on the forms of statistical observations No. 1-, 2- and 4-DOZ.

  12. İvermektin'in sığır deri papillomatozisinde tedavi etkinliği

    National Research Council Canada - National Science Library

    SÖZMEN, Mahmut; GÖKÇE, Erhan; KIRMIZIGÜL, Ali Haydar; BEYTUT, Enver; YILDIRIM, Yakup

    2010-01-01

    ...'nin sağaltımında tek doz, uzun etkili ivermektinin %87,5 oranında etkili olduğu belirlendi. In the present study the effectiveness of long action ivermectin on the treatment of bovine cutaneous...

  13. Management of Velopharyngeal Insufficiency Using Double Opposing Z-Plasty in Patients Undergoing Primary Two-Flap Palatoplasty

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    Kyung Suk Koh

    2013-03-01

    Full Text Available Background Velopharyngeal insufficiency (VPI may persist after primary repair of the cleftpalate, and surgical correction is necessary in many cases. The purpose of this study is toevaluate the effect of double opposing Z-plasty (DOZ in cleft palate patients suffering fromVPI after primary two-flap palatoplasty.Methods Between March 1999 and August 2005, we identified 82 patients who underwenttwo-flap palatoplasty for cleft palate repair. After excluding the patients with congenitalsyndrome and mental retardation, 13 patients were included in the final study group. Theaverage age of the patients who underwent DOZ at was 5 years and 1 month. Resonance,nasal emission, and articulation were evaluated by a speech pathologist. The velopharyngealgaps were measured before and after surgery.Results Six patients attained normal speech capabilities after DOZ. The hypernasality gradewas significantly improved after surgery in all of the patients (P=0.0015. Whereas nasalemission disappeared in 8 patients (61.5%, it was diminished but still persisted in the remaining5 patients. Articulation was improved in all of the cases. In two cases, the velopharyngeal gapwas measured using a ruler. The gap decreased from 11.5 to 7 mm in one case, and from 12.5 to8 mm in the second case.Conclusions The use of DOZ as a surgical option to correct VPI has many advantages comparedwith other procedures. These include short surgery time, few troublesome complications, and noharmful effects on the dynamic physiological functioning of the pharynx. This study shows thatDOZ can be another option for surgical treatment of patients with VPI after two-flap palatoplasty.

  14. Management of Velopharyngeal Insufficiency Using Double Opposing Z-Plasty in Patients Undergoing Primary Two-Flap Palatoplasty

    Directory of Open Access Journals (Sweden)

    Kyung Suk Koh

    2013-03-01

    Full Text Available BackgroundVelopharyngeal insufficiency (VPI may persist after primary repair of the cleft palate, and surgical correction is necessary in many cases. The purpose of this study is to evaluate the effect of double opposing Z-plasty (DOZ in cleft palate patients suffering from VPI after primary two-flap palatoplasty.MethodsBetween March 1999 and August 2005, we identified 82 patients who underwent two-flap palatoplasty for cleft palate repair. After excluding the patients with congenital syndrome and mental retardation, 13 patients were included in the final study group. The average age of the patients who underwent DOZ at was 5 years and 1 month. Resonance, nasal emission, and articulation were evaluated by a speech pathologist. The velopharyngeal gaps were measured before and after surgery.ResultsSix patients attained normal speech capabilities after DOZ. The hypernasality grade was significantly improved after surgery in all of the patients (P=0.0015. Whereas nasal emission disappeared in 8 patients (61.5%, it was diminished but still persisted in the remaining 5 patients. Articulation was improved in all of the cases. In two cases, the velopharyngeal gap was measured using a ruler. The gap decreased from 11.5 to 7 mm in one case, and from 12.5 to 8 mm in the second case.ConclusionsThe use of DOZ as a surgical option to correct VPI has many advantages compared with other procedures. These include short surgery time, few troublesome complications, and no harmful effects on the dynamic physiological functioning of the pharynx. This study shows that DOZ can be another option for surgical treatment of patients with VPI after two-flap palatoplasty.

  15. Investigating Post Merger Synergy and Integration of Sapura – Kencana A Case Study

    OpenAIRE

    Anwar, Edzwan Redza

    2015-01-01

    Merger and Acquisition (M&A) was the result of many contributing factors in any organization namely,corporate growth (Shrivastava, 1988), corporate strategy (School, 1987), diversification and renewal(Nahavandi & Malekzadeh, 1988), strategic alliances (Doz & Hamel, 1998), respond to financial markets (Häkkinen, 2005), all led by value creation goal. Companies see M&A as means to pursue their long term strategic goals (Gaughan, 2010). The goal is paved from strategic vision rational to create ...

  16. Physiologic Thymic Uptake as a Reason of False-Positive Uptake on Radioiodine Whole-Body Scintigraphy

    Directory of Open Access Journals (Sweden)

    Mehmet Reyhan

    2014-03-01

    Full Text Available 45 yasinda bilateral total tiroidektomi ve sag boyun diseksiyonu yapilan kadin hasta tiroid papiller karsinom ve lenf nodu metastazi tanisi almisti. Operasyondan 6 hafta sonra, hastaya yuksek doz (175 mCi, 6.4 GBq I-131 tedavisi uygulandi. Tedavi sonrasi 6. ayda 5 mCi (185 MBq I-131 ile yapilan tanisal tum vucut tarama sintigrafisinde radyoiyot tutulumu gosteren kalinti tiroid dokusu veya metastatik odak saptanmadi. Bu sirada tiroglobulin (Tg degerinin yuksek olmasi (TSH: 85.63 uIU/ml, Tg: 89.04 ng/ml, Anti-Tiroglobulin (AntiTg:

  17. Use of Ivabradine in a Patient Having Pacemaker and Inappropriate Sinus Tachycardia

    Directory of Open Access Journals (Sweden)

    Yeþim Hoþcan

    2013-05-01

    Full Text Available Ivabradin spesifik ve doz ba𽭬 If inhibitörüdür, sadece kalp hzn düürerek anti-iskemik etki gösterir. Normal sinüs ritmi olan ve beta blokerler için kontrendikasyonu veya intolerans olan hastalarda kronik stabil angina pektorisin semptomatik tedavisinde kullanlr. Ivabradini pacemaker’ olan bir hastada hz kontrolü için kulland𽭽z bir olguyu sunmaktayz.

  18. Reconstruction of national distribution of indoor radon concentration in Russia using results of regional indoor radon measurement programs.

    Science.gov (United States)

    Yarmoshenko, I; Malinovsky, G; Vasilyev, A; Zhukovsky, M

    2015-12-01

    The aim of the paper is a reconstruction of the national distribution and estimation of the arithmetic average indoor radon concentration in Russia using the data of official annual 4-DOZ reports. Annual 4-DOZ reports summarize results of radiation measurements in 83 regions of Russian Federation. Information on more than 400,000 indoor radon measurements includes the average indoor radon isotopes equilibrium equivalent concentration (EEC) and number of measurements by regions and by three main types of houses: wooden, one-storey non-wooden, and multi-storey non-wooden houses. To reconstruct the national distribution, all-Russian model sample was generated by integration of sub-samples created using the results of each annual regional program of indoor radon measurements in each type of buildings. According to indoor radon concentration distribution reconstruction, all-Russian average indoor radon concentration is 48 Bq/m(3). Average indoor radon concentration by region ranges from 12 to 207 Bq/m(3). The 95-th percentile of the distribution is reached at indoor radon concentration 160 Bq/m(3).

  19. Small pelvic varices as a cause of pathospermia and ways of its correction

    Directory of Open Access Journals (Sweden)

    A. Yu. Tsukanov

    2014-12-01

    Full Text Available Eighty patients (mean age 33.0 ± 6.2 years with idiopathic pathospermia were enrolled in the investigation. The infertility period averaged 18.8 ± 3.9 years. The patients were made up of two groups: 1 51 patients who had the signs of small pelvic varices (SPV (a study group and 2 29 patients with no signs of SPV (a comparison group, and 34 healthy volunteers also participated in the investigation. The study group was randomized to 2 subgroups: 1 phlebotropic therapy only (n = 26; 2 phlebotropic therapy in combination with AndroDoz (n = 25. The comparison group used AndroDoz only. The treatment cycle was 3 months. Analysis was made by the results of a spermogram, biochemical examination of the ejaculate, resistive index, pulsatility index, peak blood flow velocity in the intraprostatic arteries, diameter of small pelvic veins, and their reflux. Subgroup 1 of the study group showed statistically significant differences in all parameters, other than hemodynamic ones. The greatest changes were noted in subgroup 2 of the study group; there were significant changes in all the parameters.

  20. Glucocorticosteroid-induced osteoporosis: pathogenesis, prevention, treatment

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    I A Baranova

    2008-01-01

    Full Text Available Glyukokortikoidindutsirovannyy osteoporoz (GIO - odno iz naibolee tyazhelykh oslozhneniy dlitel'noy (bolee 3 mes sistemnoy terapii glyukokortikoidami (SGK. On razvivaetsya u bol'nykh lyubogo vozrasta i pola i yavlyaetsya naibolee chastoy sistemnoy formoy vtorichnogo osteoporoza (OP. Bystraya poterya kostnoy massy proiskhodit uzhe v pervye mesyatsy lecheniya SGK. Perelomy ot minimal'noy travmy voznikayut pri bolee vysokikh pokazatelyakh mineral'noy plotnosti kosti, chem u bol'nykh pervichnym OP. Dazhe ispol'zovanie malykh doz SGK privodit k povysheniyu riska perelomov, s uvelicheniem sutochnoy dozy risk perelomov vozrastaet. U patsientov, primenyayushchikh vysokie dozy ingalyatsionnykh GK (IGK, uvelichenie riska OP i perelomov v bol'shey stepeni obuslovleno tyazhest'yu respiratornogo zabolevaniya, chem terapiey IGK. Predstavleny sovremennye printsipy profilaktiki i lecheniya GIO.

  1. Making sense of intercultural interaction processes in international joint venture settings

    DEFF Research Database (Denmark)

    Dao, Li

    the role of individuals and contextual elements as well as process elements which together characterize intercultural interaction. Considering this context, two research questions are set out to guide the research: 1) How do intercultural interaction processes unfold within a Danish-Vietnamese joint...... collection, to develop a pre-understanding framework that serves as a frame of reference for the subsequent field research. The major bodies of literature that the pre-understanding builds on refer to 1) the intercultural interaction stream of research with notable contributions from the negotiated culture...... perspective (Salk, 1997; Brannen, 1998; Brannen and Salk, 2000) and the sensemaking approach to intercultural management (e.g. Osland & Bird, 2000; Kuada & Sørensen, 2010); and 2) process-oriented alliance and IJV research (e.g. Doz 1996, Ring and Van de Ven 1994). The second part (Chapters 7 to 12...

  2. 10 rules for managing global innovation.

    Science.gov (United States)

    Wilson, Keeley; Doz, Yves L

    2012-10-01

    More and more companies recognize that their dispersed, global operations are a treasure trove of ideas and capabilities for innovation. But it's proving harder than expected to unearth those ideas or exploit those capabilities. Part of the problem is that companies manage global innovation the same way they manage traditional, single-location projects. Single-location projects draw on a large reservoir of tacit knowledge, shared context, and trust that global projects lack. The management challenge, therefore, is to replicate the positive aspects of colocation while harnessing the opportunities of dispersion. In this article, Insead's Wilson and Doz draw on research into global strategy and innovation to present a set of guidelines for setting up and managing global innovation. They explore in detail the challenges that make global projects inherently different and show how these can be overcome by applying superior project management skills across teams, fostering a strong collaborative culture, and using a robust array of communications tools.

  3. Durultma maddelerinin beyaz şarabın tyrosol içeriği üzerindeki etkileri ve farklı beyaz şaraplar ile charmat metoduyla üretilen köpüklü şaraplarda tyrosol miktarının belirlenmesi

    OpenAIRE

    ALŞAN, Ayça

    2013-01-01

       Tyrosol, mayalar tarafından fermantasyon sırasında üretilen fenolik bir bileşiktir. Son zamanlarda bu molekülün sağlık üzerindeki etkileri ile ilgili pek çok makale yazılmıştır. Araştırma, iki temel çalışma üzerine kurulmuştur. Bunlardan birincisi, farklı durultma maddelerinin şarabın tyrosol içeriği üzerindeki etkisinin belirlenmesi olup, her durultma maddesi için yüksek, normal ve düşük doz uygulamaları olmak üzere üç konsantrasyon seçilmiştir. Bu çalışma için ...

  4. Mineralogical discrimination of the pleistocene loess/paleosol sections in Srijem and Baranja, Croatia

    Science.gov (United States)

    Galović, Lidija; Peh, Zoran

    2016-06-01

    Previous investigations of the mineralogical composition of loess sections (loess, loess-like sediments, paleosols, alluvial intercalations) in the Carpathian Basin have concluded that the Danube River is the dominant control on the loessitic parent material. These investigations also identify a significant role for the Danube's tributaries in creating local variations. The north-south alignment of these sections forms a transect from the central part of the Carpathian Basin to its southern edge. In this work, the mineral origin of loess sediments was identified by using the multivariate statistical method of discriminant function analysis. Two models were constructed based on the modal composition as the suite of predictor (independent) variables: one is using geographic location as the a priori grouping criterion (SECTION); another employing the difference between the sampling media (LITHOLOGY). Both of the examined discriminant models demonstrate the existence of the mixing zones. The Erdut section is a clear mixture of the mineralogies at the other studied locations, while loesses appear generally intermediate in mineralogy between alluvium and paleosol. The main rationale for the observed difference in modal composition between the Šarengrad and other analyzed sections is the proximity of the Šarengrad section to the Sava River floodplain and Dinaric Ophiolite Zone (DOZ), both important source areas for aeolian sediments in the southern edge of the Carpathian Basin that transport material from the Central Bosnian Mountains unit of DOZ. Chemically, the most resistant heavy minerals together with opaque minerals are exclusively associated with paleosols, being typical products of geochemical pedogenic processes.

  5. 黄山部分药用苔藓植物资源调查%Survey on Partial Resources of Medicinal Bryophytes in Mount Huangshan of Anhui Province

    Institute of Scientific and Technical Information of China (English)

    吴明开; 师雪芹

    2011-01-01

    黄山地区药用苔藓植物资源丰富,种类多,分布广,蕴藏量较大,对其中的19种药用苔藓植物生境分布、药用功效作了初步调查,结果表明:鳞叶藓[Taxiphyllum taxirameum (Mitt.)Fleisch.]、金发藓(Polytrichum commune Hedw.)、东亚小金发藓[Pogonatum inflexum(Lindb.)Lac.]、大灰藓(Hypnum plumaeforme Wils.)、细叶小羽藓[Haplocladium microphyllum (Hedw.)Broth.]、大羽藓[Thuidium cymbifolium(Doz.et Molk.)B.S.G.]、匍灯藓[Plagiomnium cuspidatum(Hedw.)T.Kop.]、真藓(Bryum argenteum Hedw.)、葫芦藓(Funaria hygrometrica Hedw.)、黄牛毛藓[Ditrichum pallidum(Hedw.)Hampe]和地钱(Marchantia polymorpha L.)等蕴藏量较大,可供开发利用.%The resources of medicinal bryophytes in Huangshan Mountain are abundant with various species, wide distribution and plentiful re-serves. The distribution district and medicinal efficacies of nineteen species of medicinal bryophytes were investigated, and the results showed that: Taxiphyllum taxirameum (Mitt.) Fleisch. , Polytrichum commune Hedw), Pogonatum in flexum (Lindb.) Lac. , Hypnum plumaeforme Wils. , Haplocladium microphyllum ( Hedw. ) Broth. , Thuidium cymbifolium ( Doz. et Molk. ) B. S. G. , Plagiomnium cuspidatum ( Hedw. )T. Kop. , Bryum argenteum Hedw. , Funaria hygrometrica Hedw. , Ditrichum pallidum ( Hedw. ) Hampe and Marchantia polymorpha L. distributed in Mount Huangshan with vast reserves, which are capable of meeting the development.

  6. Personnel dose assessment due to the normal operations with the artificial radiation sources according to the data from the unified system of individual dose control (USIDC

    Directory of Open Access Journals (Sweden)

    Yu. I. Stepkin

    2016-01-01

    Full Text Available The aim of the study was personnel dose assessment due to the normal operations with the artificial radiation sources. The article is based on the data from the Unified System of Individual Dose Control and Voronezh Region’s radiation-hygienic passport. The data from No.1-DOZ “Information on personnel exposure doses under normal operation of technogenic ionizing radiation sources” and over a period of 2006-2010 years were analyzed. In 2006-2015, the number of organizations, which submitted form No.1-DOZ “Information on personnel exposure doses under normal operation of technogenic ionizing radiation sources”, increased from 175 to 229. In amount of the radiation facilities, Novovoronezh Nuclear Power Plant is the first. Novovoronezh NPP has 1512 sources, which amounts to 51,9% from all sources in Voronezh Region (2915. Health care facilities have 869 radiation sources or 29,8%. X-ray machines are the main part of these sources (844 health care facilities or 97,1% of all medical sources. Industrial sources occupy third place with 305 facilities or 10,5% of all considered sources. In 2015, according to the data from Voronezh Region’s radiation-hygienic passport, the number of “A” group personnel were 4237, the number of “B” group personnel were 2341. The average individual dose for personnel was over the range from 0.66 to 2.02 mSv. Collective dose was from 4.16 to 11.79 man-sieverts per year. The increase of number of the radiation sources has attended with the decrease of individual and collective doses. The most likely it is related to using the modern facilities. In 2015, the maximum value of the average individual dose of “A” group personnel was registered in Voronezh regional hospital (6.17 mSv y–1. There are medical facilities with unsealed and sealed sources in this hospital. In 2006-2015, the average individual doses of personnel of all radiation facilities that use radiation sources in Voronezh

  7. ANALYSIS OF DATA ON DOSES OF EXTERNAL TERRIGENOUS IRRADIATION OF THE RUSSIAN FEDERATION POPULATION IN MUNICIPAL CONDITIONS

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    I. P. Stamat

    2015-01-01

    Full Text Available By this time in the Russian Federation there is collected a huge file of data describing the influence of all natural sources of ionizing radiation on population in municipal conditions. These data are collected and generalized in radiation hygiene passports of the Russian Federation for the last 16 years and in the reporting forms of federal statistical supervision No 4-DOZ “Data on doses of population irradiation due to the natural and manchanged radiation background” for a period of 14 years. These data are received by direct measurements of gamma radiation dose rate in the premises and in the open air on the territory of settlements. Measurements were made with the most different dosimeters; their technical and metrological parameters differ considerably. In this regard of certain interest is evaluation of this data reliability degree; that will help to find out the reasons of higher levels of the Russian Federation population external irradiation in comparison with average global dose values.In this article an attempt was made to evaluate reliability degree of data on the population external irradiation doses using the radiation hygiene passports of territories and reporting forms No 4-DOZ for the whole period of supervision. For this there was used the known dependence between the gamma radiation dose rate and natural radionuclides effective specific activity (AEFF in inhabitancy objects. For this purpose there were used the data on average AEFF values of building raw materials and of local manufacture materials, which are presented in radiation hygiene passports of territories. Definition of design value of gamma radiation dose rate in the buildings and in the open air according to AEFF measurement data in building raw materials and in local manufacture materials actually enables to get an independent evaluation of the population external irradiation doses. Comparison of two evaluations of the population external irradiation levels

  8. PFAPA sendromu Çağrılı Editör

    OpenAIRE

    Kasapçopur, Özgür; Arısoy, Nil

    2009-01-01

    PFAPA sendromu çocukluk çağında yineleyen ateş aftöz stomatit farenjit ve servikal adenitle ortaya çıkan bir otoenflamatuar hastalıktır Hastalık çoğunlukla beş yaşın altında ortaya çıkar Hastalığa ait ateş atakları düzensiz aralıklarla yineler ve ortalama 3 4 sürüp kendiliğinden düzelir Ateş çocuklarda genellikle 39 derecenin üzerindedir ve tüm antibiyotik ve ateş düşürücü tedavilere yanıtsızdır Hastalardaki klinik bulguların tümü tek doz kortikosteroid uygulaması ile hemen kaybolur Kalıcı te...

  9. Identification of Major Authors in Coopetition

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    Valdir Antonio Vitorino Filho

    2013-06-01

    Full Text Available This article aims to identify the main perpetrators in coopetition through two approaches: (a analyze based on bibliometric study of co-citation producing academic articles available on the ISI web of knowledge on the subject coopetition in 65 articles found in publications between 1996 and 2011, (b identify the most cited authors by Brazilian researchers on the topic coopetition, and yet, the subjects and objects of study used in 26 research publications between 2004 and 2012. The study is characterized as descriptive and quantitative analysis of the data with the aid of software Stikis® 2.0 and Ucinet® 6.0. The results show that (a international research had in a growing number of publications, (b there are no researchers nationally and internationally that stand out with the highest number of publications in the area, (c have been identified as major authors and their their works in coopetition: Hamel, Doz and Prahalad (1989, Nalebuff and Brandenburger (1996; Lado, Boyd and Hanlon (1997 and Bengtsson and Kock (1999 and 2000.

  10. Study of plasticizer diffusion in a solid rocket motor´s bondline

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    Juliano Libardi

    2009-06-01

    Full Text Available This work aims to determine the diffusion coefficient of the plasticizers dibutyl phthalate (DBP, dioctyl phthalate (DOP and dioctyl azelate (DOZ on the internal insulating layer of solid rocket motors. These plasticizers are originally present in the layers of rubber, liner and propellant, respectively. This species are not chemically bonded and tend to diffuse from propellant to insulating and vice versa. A computer program based on the mathematical model of Fick’s second Law of diffusion was developed to perform the calculus from the concentration data obtained by gas chromatographic (GC analyses. The samples were prepared with two different adhesive liners; one conventional (LHNA and the other with barrier properties (LHNT. A common feature of both liners was that they were synthesized by the reaction of hydroxyl-terminated polybutadiene (HTPB and diisocyanates. However, a bond promoter was used to increase the crosslink density of the LHNT liner and to improve its performance as barrier against the diffusion. The effects of the diffusion of the plasticizers were also investigated by hardness analyses, which were executed on samples aged at room temperature and at 80ºC. The results showed an increase trend for the samples aged at room temperature and an opposite behavior for the tests carried out at 80ºC.

  11. Diffusion of plasticizer in a solid propellant based on hydroxyl-terminated polybutadiene

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    Juliano Libardi

    2010-01-01

    Full Text Available The aim of this work was to determine the dioctyl azelate (DOZ plasticizer diffusion coefficient (D for samples containing the interfaces of rubber, liner and solid composite propellant based on hydroxyl-terminated polybutadiene (HTPB. The samples used in the diffusion study were aged up to 31 days after the cure period at 80 °C. A computer program implementing a mathematical model of Fick's second Law of diffusion was developed to calculate the diffusion coefficient based on concentration data obtained from gas chromatographic analyses. The effects of the diffusion phenomenon were also investigated by Shore A hardness and scanning electron microscope (SEM techniques. These analyses were carried out using samples aged at room temperature and at 80 °C. The hardness results showed an increasing trend for the samples aged at room temperature; however in the tests carried out at 80 °C they showed the opposite trend. The SEM analyses detected meaningful changes in the surface morphology of the propellant for both aging temperatures.

  12. Radionuclide diagnostics in St. Petersburg: сurrent status and development challenges

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    I. A. Zvonova

    2015-01-01

    Full Text Available This work aims at radionuclide diagnostics analyses in the Russian Federation city of St. Petersburg over 2005–2014. The study covers trends and development challenges , availability of radionuclide diagnostics for population needs, exposure doses for patients.This work aims at radionuclide diagnostics analyses in the Russian Federation city of St. Petersburg over 2005–2014. The study covers trends and development challenges , availability of radionuclide diagnostics for population needs, exposure doses for patients.Materials and methods. The radionuclide diagnostics temporal and structural changes’ analysis was based on Federal state statistical observation forms No.3-DOZ for St. Petersburg and on the results of radionuclide diagnostics subdivision surveys with radiology physicians’ questionnaires on the amount and composition of conducted examinations, dosages of introduced radioactivity of radiopharmaceticals and patients’ doses.The results. Since the end of 1990s until 2012 the amount of radionuclide diagnostics procedures had been steadily reducing. 74000 procedures were conducted in 2005 and 35500 in 2012. The number of radionuclide diagnostics procedures per one thousand residents reduced from 16 to 7.2. Both indicators slightly grew in 2013. In 2014 the total number of radiodiagnostic proceduress amounted up to 42000 and 8.2 tests per 1000 residents. Since 2011 the diagnostic equipment was upgraded. Four medical institutions received SPECT (single photon emission computed tomography or SPECT/CT, two new PET ( positron emission tomographs – centers were set up, three medical institutions had acquired positron emission tomographs (PET and are conducting PET – diagnostics receiving radiofarmaceuticals from external PET – center. At the same time one a third of radiodiagnostic units still has been operating obsolete and depreciated equipment dating back to 1980–1990 .Inspection results indicated that St. Petersburg

  13. Süleyman Demirel Üniversitesi'nde Bina İçi Radon Konsantrasyonlarının Nükleer İz Dedektörleri Kullanılarak Belirlenmesi

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    Mehmet Ertan KÜRKÇÜOĞLU

    2014-07-01

    Full Text Available Kapalı ortamlarda zamanla birikebilen radon gazı alfa parçacıkları yayımlar ve doğal radyoaktivitenin yarısından doğrudan sorumludur. Yüksek seviyede radon ihtiva eden ortamlarda radon ve radon ürünlerinin solunması, akciğerde kanser oluşumuyla bağdaştırıldığından radon konsantrasyonlarının kapalı mekanlar için belirlenmesi oldukça önemlidir. Bu çalışmada, 10 bin dekarlık alana sahip Süleyman Demirel Üniversitesi'nde üçü doğu yerleşkesi, ikisi batı yerleşkesinde olmak üzere toplam beş binadaki (Ziraat Fakültesi, Hukuk Fakültesi, Atatürk Spor Salonu, Mühendislik ve Mimarlık Fakültesi ile Bilgi İşlem Merkezi'ndeki atmosferik radon düzeyleri 92 ölçüm noktasına yerleştirilen CR-39 nükleer iz dedektörleri ile ölçülmüştür. Bu ölçümler yaklaşık 8 haftalık bir süre boyunca, 2010 yılı Mayıs ile Temmuz ayları arasında yapılmıştır. Dedektörlerin analizleri sonucunda; Mühendislik ve Mimarlık Fakültesi, Ziraat Fakültesi, Hukuk Fakültesi, Atatürk Spor Salonu ve Bilgi İşlem Merkezi'ndeki bina içi ortalama radon konsantrasyonlarının sırasıyla 259 Bq/m3, 279 Bq/m3, 265 Bq/m3, 324 Bq/m3 ve 173 Bq/m3 olduğu tespit edilmiştir. Ayrıca bu birimleri kullanan personel ve öğrencilerin radon nedeniyle alacakları tahmini doz miktarları hesaplanmış ve yıllık etkin doz eşdeğerlerinin, yine aynı sırayla 2,7 mSv, 2,9 mSv, 2,8 mSv, 3,4 mSv ve 1,8 mSv düzeyinde olduğu bulunmuştur.

  14. Japon Balığı (Carassius auratus Linnaeus, 1758 Dokularında Bor Akümülasyonu

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    Tuncer Okan Genç

    2015-03-01

    Full Text Available Bu çalışmada, model bir balık türü olabilen Japon balığının (Carassius auratus Linnaeus, 1758 karaciğer ve kas dokusundaki, yem ve su kaynaklı bor birikiminin dağılımı incelenmiştir. Her bir uygulama için her bir akvaryuma 12 adet birey. Uygulamalarda, akvaryum gruplarının suyuna belirli oranlarda (1 mg/L, 10 mg/L ve 20 mg/L borik asit ve borik asit emdirilmesi ile elde edilen yemlerden (1 mg/kg, 5 mg/kg ve 10 mg/kg verilmiştir. Dokulardaki bor birikimi mikrodalga yaş yakma ile çözündürme işleminin ardından indüktif olarak eşleştirilmiş kütle spektroskopisi (ICP-MS tekniği ile belirlenmiştir. Japon balıklarının farklı dokularında belirlenen maksimum bor konsantrasyonu 20mg/L sulandırılmış borik asit uygulamasında karaciğer dokusunda (1.78±0.02 mg/kg tespit edilmiştir. Ancak 1 mg/kg yem uygulamasında kas dokusunda birikim olmadığı gözlemlenmiştir. Borlu su grupların için Transfer faktör (TF en düşük dozda en yüksek oranda iken doz miktarı arttıkça TF azalmış ve neredeyse 0.1’e yakın bir sabitlik göstermiştir. Bor ilaveli yem kullanılan deney gruplarında TF en düşük dozda (1 mg/kg 0 iken yemde kullanılan borun doz miktarı arttıkça (5 mg/kg TF değerinin yaklaşık 0.06’ya kadar çıktığı tespit edilmiştir. Bu çalışmada önemli iki tespit ortaya konulmuştur; bor birikiminde hedef organlardan biri karaciğer iken kas dokusunun birikim açısından hedef olmadığı ve yem ile alınan borun dokularda birikiminin düşük olmasıdır.

  15. THE HISTORY OF ESTABLISHMENT OF THE NATURAL SOURCES DOSIMETRY LABORATORY IN THE INSTITUTE OF RADIATION HYGIENE AFTER PROFESSOR P.V. RAMZAEV, 1987–2005

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    I. P. Stamat

    2016-01-01

    Full Text Available The first 5–7 years of the period under review in the history of the Natural Sources Dosimetry Laboratory happened to be in very hard period, which had a time the entire country. A severe funding reduction of the Institute in the 90-s created a threat of loss of the most active and highly professional middle-aged specialists. In these conditions, the only and the most efficient way to maintain Institute as a scientific establishment was to organize the Federal Radiological Center under the guidance of Dr. A.N. Barkovskiy. The Federal Radiological Center consisted of the all physical laboratories, including the Natural Sources Dosimetry Laboratory, without government funding. Nevertheless, as it is shown below, this period was the most fruitful for theoretical and experimental researches, and for development of legal documents and instructional guidance documents. Over these years, more than 10 sanitary regulations and hygienic standards, and more than 20 guidance documents were developed and implemented. Doses of the population due to the natural exposure data-collecting system on the base of federal statistical observation №4-DOZ form were designed. At this period, the first Federal Target Program «Radon» and the System of radiation and hygienic passportization of organizations and territories were developed and authorized. Dr. E.M. Krisiuk was fully engaged in these activities. In these years a great number of non-nuclear companies were examined. Large-scale studies of levels of exposure of the population on specific territories were conducted. The paper examines a summary of the main results, which were obtained in the most important areas of research and practical studies in the period under review.

  16. Radiation conditions in the Oryol region territory impacted by radioactive contamination caused by the Chernobyl NPP accident

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    G. L. Zakharchenko

    2016-01-01

    Full Text Available Research objective is retrospective analysis of radiation conditions in the Oryol region during 1986- 2015 and assessment of efficacy of the carried out sanitary and preventive activities for population protection against radiation contamination caused by the Chernobyl NPP accident.Article materials were own memoirs of events participants, analysis of federal state statistic surveillance forms 3-DOZ across the Oryol region, f-35 “Data on patients with malignant neoplasms, f-12 “Report on MPI activities”. Risk assessment of oncological diseases occurrence is carried out on the basis of AAED for 1986- 2014 using the method of population exposure risk assessment due to long uniform man-made irradiation in small doses. Results of medical and sociological research of genetic, environmental, professional and lifestyle factors were obtained using the method of cancer patients’ anonymous survey. Data on "risk" factors were obtained from 467 patients hospitalized at the Budgetary Health Care Institution of the Oryol region “Oryol oncology clinic”; a specially developed questionnaire with 60 questions was filled out.The article employs the method of retrospective analysis of laboratory and tool research and calculation of dose loads on the Oryol region population, executed throughout the whole period after the accident.This article provides results of the carried out laboratory research of foodstuff, environment objects describing the radiation conditions in the Oryol region since the first days after the Chernobyl NPP accident in 1986 till 2015.We presented a number of activities aimed at liquidation of man-caused radiation accident consequences which were developed and executed by the experts of the Oryol region sanitary and epidemiology service in 1986-2015. On the basis of the above-stated one may draw the conclusions listed below. Due to interdepartmental interaction and active work of executive authorities in the Oryol region, the

  17. The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.

    Science.gov (United States)

    Khan, Nadia; Saad, Ali; Nurulain, Syed M; Darras, Fouad H; Decker, Michael; Sadek, Bassem

    2016-01-15

    Both the histamine H3 receptor (H3R) and acetylcholine esterase (AChE) are involved in the regulation of release and metabolism of acetylcholine and several other central neurotransmitters. Therefore, dual-active H3R antagonists and AChE inhibitors (AChEIs) have shown in several studies to hold promise to treat cognitive disorders like Alzheimer's disease (AD). The novel dual-acting H3R antagonist and AChEI 7-(3-(piperidin-1-yl)propoxy)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline (UW-MD-71) with excellent selectivity profiles over both the three other HRs as well as the AChE's isoenzyme butyrylcholinesterase (BChE) shows high and balanced in vitro affinities at both H3R and AChE with IC50 of 33.9nM and hH3R antagonism with Ki of 76.2nM, respectively. In the present study, the effects of UW-MD-71 (1.25-5mg/kg, i.p.) on acquisition, consolidation, and retrieval in a one-trial inhibitory avoidance task in male rats were investigated applying donepezil (DOZ) and pitolisant (PIT) as reference drugs. Furthermore, the effects of UW-MD-71 on memory deficits induced by the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (DIZ) were tested. Our results indicate that administration of UW-MD-71 before the test session dose-dependently increased performance and enhanced procognitive effect on retrieval. However neither pre- nor post-training acute systemic administration of UW-MD-71 facilitated acquisition or consolidation. More importantly, UW-MD-71 (2.5mg/kg, i.p.) ameliorated the DIZ-induced amnesic effects. Furthermore, the procognitive activity of UW-MD-71 in retrieval was completely reversed and partly abrogated in DIZ-induced amnesia when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL), but not with the CNS penetrant H1R antagonist pyrilamine (PYR). These results demonstrate the procognitive effects of UW-MD-71 in two in vivo memory models, and are to our knowledge the first demonstration in vivo that a potent dual

  18. MODERN PECULIARITIES OF THE MEDICAL EXPOSURE LEVELS FORMING OF THE TATARSTAN REPUBLIC POPULATION DURING X-RAY PROCEDURES IMPLEMENTATION

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    S. A. Ryzhkin

    2015-01-01

    Full Text Available The purpose. The purpose of the investigation is an assessment of the peculiarities of forming and registration of the collective doses of patients and the population of the Tatarsatan Republic (RT from medical exposure and the development of measures for optimization of this radiation factor.Materials and methods. The analysis is based on the forms of the Federal statistical observation № 3-DOZ «Data on the exposure doses to patients obtained during medical radiological examination» (form № 3-DOZ and radiation-hygienic passports of RT for the period from 2006 to 2013.The results. Annually in RT there is an increase of the number of performed X-ray procedures, which reached the value of 6279696 (1.64 procedures per resident per year in 2013. During the reporting period (from 2006 to 2013 the structure of the performed X-ray procedures has also changed. It is observed that the percentage of fluorography procedures in the overall structure decreased from 41.3% to 31.3% at the same time the level of absolute value of annually performed fluorography procedures is stable. There is an increase in the absolute number of radiographic procedures performed during the period from 2578754 to 4072810 X-rays per year, that is 1.58 times higher. Absolute and relative values related to X-ray fluoroscopy examinations decreased from 1.1% to 0.7%. In contrast, the absolute number of annually performed X-ray computed tomography examinations (CT has increased over the period by 3.3 times and percentage of CT in overall structure of X-ray procedure is 2.7%. The number of special investigations has increased in 2.1 times, but the relative value remained at average level of 0.4% on general background of the increasing of X-ray activity in the region. This fact influenced the change in the radiation-hygienic indexes of medical radiation exposure of the population of RT. According to №3-DOZ forms and radiation-hygienic passports of the

  19. A New Water Electrode Method for Accelerating Ageing of XLPE Cable%一种加速XLPE电缆水树老化的新型水电极法

    Institute of Scientific and Technical Information of China (English)

    杨滴; 周凯; 杨明亮; 赵威; 陶文彪; 尧广

    2015-01-01

    A new water electrode method, which can accelerate the growth of water tree in XLPE cable insulation, was presented based on the old water electrode method, and its ageing mechanism was dis-cussed. Aged XLPE cable samples were prepared by the new water electrode method, and their dielectric loss tangle (tanδ) during the ageing process was tested. The micro-structure and morphology change of water tree in the cable samples were analyzed by optical microscope, infrared spectrum (IR), and scan-ning electron microscope (SEM), and a micro ageing model was presented. The results show that the size and micro-structure of the water trees generated by the improved water electrode method are almost the same. The size of water tree is between 300 μm and 400 μm, and the water tree is clump-shaped. The diameter of the micropore or channel in water tree defects ranges from a few micrometers to doz-ens of micrometers. The new water electrode method is more effective and stable to generate the water tree with typical structure and characteristic in the cable samples, which provides reliable guarantee to study the ageing mechanism of cable insulation.%基于原有的水电极老化方法,提出了一种能有效加速XLPE电缆绝缘中水树生长的新型水电极法,并针对该方法的老化机制进行了讨论。采用改进后的新型水电极法老化XLPE电缆制作水树样本,测量老化过程中电缆样本的介质损耗正切角(tanδ)的变化。利用光学显微镜、红外光谱(IR)和扫描电镜(SEM)分析电缆样本中水树的微观结构和形貌变化,提出相应的微观老化模型。结果表明:采用改进后的水电极法生成的水树尺寸和微观形貌差异较小,水树长度在300~400μm之间,水树形貌为团状,水树缺陷内部微孔或通道的直径在几微米到几十微米之间。采用新型水电极法老化的电缆试样稳定有效,可生成符合典型结构和特征的水树,为进一

  20. The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.

    Science.gov (United States)

    Sadek, Bassem; Khan, Nadia; Darras, Fouad H; Pockes, Steffen; Decker, Michael

    2016-10-15

    Both the acetylcholine esterase (AChE) and the histamine H3 receptor (H3R) are involved in the metabolism and modulation of acetylcholine release and numerous other centrally acting neurotransmitters. Hence, dual-active AChE inhibitors (AChEIs) and H3R antagonists hold potential to treat cognitive disorders like Alzheimer's disease (AD). The novel dual-acting AChEI and H3R antagonist 7-(3-(piperidin-1-yl)propoxy)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one (UW-MD-72) shows excellent selectivity profiles over the AChE's isoenzyme butyrylcholinesterase (BChE) as well as high and balanced in-vitro affinities at both AChE and hH3R with IC50 of 5.4μM on hAChE and hH3R antagonism with Ki of 2.54μM, respectively. In the current study, the effects of UW-MD-72 (1.25, 2.5, and 5mg/kg, i.p.) on memory deficits induced by the muscarinic cholinergic antagonist scopolamine (SCO) and the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (DIZ) were investigated in a step-through type passive avoidance paradigm in adult male rats applying donepezil (DOZ) and pitolisant (PIT) as reference drugs. The results observed show that SCO (2mg/kg, i.p.) and DIZ (0.1mg/kg, i.p.) significantly impaired learning and memory in rats. However, acute systemic administration of UW-MD-72 significantly ameliorated the SCO- and DIZ-induced amnesic effects. Furthermore, the ameliorating activity of UW-MD-72 (1.25mg/kg, i.p.) in DIZ-induced amnesia was partly reversed when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL, 10mg/kg, i.p.), but not with the CNS penetrant H1R antagonist pyrilamine (PYR, 10mg/kg, i.p.). Moreover, ameliorative effect of UW-MD-72 (1.25mg/kg, i.p.) in DIZ-induced amnesia was strongly reversed when rats were pretreated with a combination of ZOL (10mg/kg, i.p.) and SCO (1.0mg/kg, i.p.), indicating that these memory enhancing effects were, in addition to other neural circuits, observed through histaminergic H2R as well as

  1. Effects of pentoxifylline on proliferation of human umbilical vein endothelial cells (HUVEC

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    Eyup Çağatay Zengin

    2016-09-01

    Full Text Available SUMMARY Objective: The aim of this study was to investigate the effect of pentoxifylline (PNX with a pharmacological dose range on proliferation of human umblical venous endothelial cells (HUVEC. Method: The cells were maintained in M199 supplemented with 20% fetal bovine serum, penicillin, and streptomycin. The cultures were cultivated in an incubator at 37°C and with 5% CO2, until cell monolayers attained confluence which occurred after 7 days. The assays were performed in the exponential growth phase of the cells. The cell viability was assessed using the cleavage of tetrazolium salts added to the culture medium. Pentoxifylline with concentrations of 10-4M, 10-5M, 10-6M and 10-7M were used for the proliferation assay in which cells were incubated for 24, 48, and 72-hours with these drugs. The experiments were conducted in six replicates. Results: Only the 10-4M dose of PNX at 72 h significantly reduced the viability of HUVEC (p0.05. Conclusions: Overall, PTX with a pharmacological dose range has no cytotoxic effect on HUVEC. We think that this is also in accordance with the findings of several studies performed in animal models and clinical settings, indicating positive effects of PTX on tissues in normal and ischemic conditions. Keywords: Pentoxifylline, proliferation, human umbilical venous endothelial cells ÖZET Amaç: Bu çalışmanın amacı farmokolojik doz aralığında uygulanan pentoksifilinin insan umblikal ven endotel hücrelerinin (HUVEC proliferasyonu üzerine etkisini araştırmaktır. Yöntem: Hücreler içerisine %20 fetal bovine serum, penisilin ve streptomisin eklenen M199 besiyeri içinde, %5 CO2 içeren 37 ̊C ‘lik inkübatörde kültüre edildi. Deneyler hücreler gelişim fazında iken gerçekleştirildi. Hücrelerin canlılığı kültür ortamına tetrazolium tuzları eklenerek değerlendirildi. Pentoksifilinin 10-4M, 10-5M, 10-6M and 10-7M konsantrasyonları, 24, 48 ve 72. saatlerde değerlendirildi. Deneyler alt

  2. EFFECTS OF AMARANTHS’ SEEDS ON DEHYDROGENASE ACTIVITY AND GASES EMISSION IN METHANOGENIC BIOREACTORS

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    Victor COVALIOV

    2015-12-01

    studiată influenţa preparatelor din seminţe de amarant, ca sursă de scualen, asupra activitatăţii dehidrogenazei şi eficienţei producerii metanului în procese anaerobe. Adaugarea preparatelor de seminţe de amarant în bioreactorul metanogen are un efect inhibitor asupra activităţii dehidrogenazei şi stimulează procesul de metanogeneză. Activitatea dehidrogenazei a scăzut odată cu creşterea dozelor de preparat din seminţe de amarant, iar trendul a fost în legătură strânsă cu dozele (R2 = 0,77-0,78. În bioreactorul cu aditiv din seminţe de amarant, în doză optimă de 50 mg l-1, conţinutul de metan în volumul total de gaze emise a fost de 65,3-71,3%, ceea ce este cu 22,1% mai mare faţă de bioreactorul de control, fără aditiv. Ridicarea concentraţiei aditivului, calculată în scualen, mai sus de 0,0005% nu este raţională, deoarece după această valoare efectul de stimulare a procesului metanogen scade. Digestia anaerobă a deşeurilor din industria de distilare a alcoolului cu gunoi de grajd este un proces microbiologic complex care variază neliniar în timp. Trendul activităţii dehidrogenazei în experiment este descris de funcţia de putere pentru 5 ore de observaţii şi de funcţia logaritmică pentru 120 ore de observaţii. Tendinţele acumulării CH4 în toate perioadele de testare sunt descrise de o funcţie polinomială. Coeficienţii de corelaţie pentru CH4 sunt 0,37 şi 0,70, respectiv pentru 5 şi 120 ore de digestie anaerobă. Activitatea dehidrogenazei este în relaţie negativă cu cantitatea de gaze, inclusiv de metan. Analiza corelaţiilor dintre activitatea dehidrogenazei şi emisiile de gaze a indicat la o legătura moderată şi puternic negativă timp de 24 de ore de la iniţierea experimentului.

  3. 11th Congress of South-East European Studies. Sofia 2015

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    Mirella Korzeniewska-Wiszniewska

    2015-12-01

    éen. Europa Południowo-Wschodnia jest obszarem, do którego światowe mocarstwa podchodzą z dużą dozą ambiwalencji. Kraje tego regionu nie są głównymi graczami na arenie światowej, przez co wydarzenia związane z tą częścią Europy spotykają się z cyklicznym zainteresowaniem powstającym zazwyczaj w obliczu problemów, które - równie cykliczne wywoływane - zwracają uwagę świata na ten relatywnie nieduży region. Jest on jednak bezsprzecznie obszarem, który wzbudza zainteresowanie badaczy od ponad stu lat ze względu na swoje zróżnicowanie etniczne, pociągające za sobą rdzenną wielonarodowość regionu, niewystępującą na taką skalę gdzie indziej w Europie. Związana z tym wielość kultur, języków i religii generuje często specyficzne dla tej szerokości geograficznej amalgamaty społecznościowe. Również od nieco ponad stu lat o wpływy w tym regionie (abstrahując od wspomnianej cykliczności zainteresowania zabiegają główne europejskie siły polityczne (a obecnie nie tylko europejskie ze względu położenie geograficzne, w którym Zachód spotyka Wschód. Bez względu na dynamikę zainteresowania Europą Południowo-Wschodnią jest i będzie ona bezsprzecznie fascynującym obszarem badań naukowców całego świata, którzy ponownie spotkają się za cztery lata na kolejnym kongresie, tym razem w rumuńskiej Constanzy, aby pochylić się nad zagadnieniami związanymi z tą częścią świata.

  4. Geochemistry of mylonitic tourmaline-bearing granite- gneiss pluton in the northeast of June mine

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    Arezoo Moradi

    2017-07-01

    Full Text Available Introduction Studied mylonitic granite-gneiss body is located in the Northwest of the Azna region in the Lorestan province close to the June dimension stone mine. It is a part of the metamorphic- magmatic complex including granite-gneiss, amphibolite, marble and schist. The crystalline basement is attributed to late-Neoproterozoic and it indicates a Panafrican basement, which yields a laser-ablation ICP–MS U–Pb zircon ages of 608 ± 18 Ma and 588 ± 41 Ma (Shakerardakani et al., 2015. There are two granite-gneiss plutons in the complex that are Galeh– Dezh (Shabanian et al., 2009, and June plutons. The Galeh-Doz pluton are previously proposed as syn-deformation pluton with a major S-shaped bend which has been imparted during dextral shearing with a Late Cretaceous (Mohajjel and Fergusson, 2000. However, new age dating on the pluton using U–Pb in the magmatic zircon produced the late-Neoproterozoic dates (Nutman et al., 2014; Shakerardakani et al., 2015. The granite-gneiss plutons show mylonitic fabrics and microstructures (Shabanian et al., 2010. The geochemical characteristics of mylonitic granite-gneiss body near June mine in NW Azna, is in the focus of our research. Materials and methods Petrographic investigations of 30 thin sections were made. Then eight samples were selected and analyzed for whole rock major, trace and REE compositions by ICP-emission spectrometry and ICP-mass spectrometry using natural rock standards as reference samples for calibration at the ACME Analytical Laboratories in Vancouver, British Columbia, Canada. Results The studied gneiss- granitic body has lepido-granoblastic texture as its major texture. It variably shows evidence of dynamic deformation from ultramylonite to protomylonite. The gneiss- granite consists of quartz, alkali feldspar (mostly as perthite, plagioclase, biotite, white mica (muscovite and phengitic muscovite. Accessory phases in the granitoid include, tourmaline, zircon, magmatic epidote