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Sample records for double group spinor

  1. Clifford algebras, spinors, spin groups and covering groups

    International Nuclear Information System (INIS)

    Magneville, C.; Pansart, J.P.

    1991-03-01

    The Dirac equation uses matrices named Υ matrices which are representations of general algebraic structures associated with a metric space. These algebras are the Clifford algebras. In the first past, these algebras are studied. Then the notion of spinor is developed. It is shown that Majorana and Weyl spinors only exist for some particular metric space. In the second part, Clifford and spinor groups are studied. They may be interpreted as the extension of the notion of orthogonal group for Clifford algebras and their spaces for representation. The rotation of a spinor is computed. In the last part, the connexion between the spinor groups and the Universal Covering Groups is presented [fr

  2. Towards pure spinor type covariant description of supermembrane - an approach from the double spinor formalism

    International Nuclear Information System (INIS)

    Aisaka, Yuri; Kazama, Yoichi

    2006-01-01

    In a previous work, we have constructed a reparametrization invariant worldsheet action from which one can derive the super-Poincare covariant pure spinor formalism for the superstring at the fully quantum level. The main idea was the doubling of the spinor degrees of freedom in the Green-Schwarz formulation together with the introduction of a new compensating local fermionic symmetry. In this paper, we extend this 'double spinor' formalism to the case of the supermembrane in 11 dimensions at the classical level. The basic scheme works in parallel with the string case and we are able to construct the closed algebra of first class constraints which governs the entire dynamics of the system. A notable difference from the string case is that this algebra is first order reducible and the associated BRST operator must be constructed accordingly. The remaining problems which need to be solved for the quantization will also be discussed

  3. World spinors revisited

    International Nuclear Information System (INIS)

    Sijacki, Dj.

    1998-01-01

    World spinors are objects that transform w.r.t. double covering group Diff(4, R) of the Group of General Coordinate Transformations. The basic mathematical results and the corresponding physical interpretation concerning these, infinite-dimensional, spinorial representations are reviewed. The role of groups Diff(4, R), GA(4, R), GL(4, R), SL(4, R), SO(3,1) and the corresponding covering groups is pointed out. New results on the infinite dimensionality of spinorial representations, explicit construction of the SL(4, R) representations in the basis of finite-dimensional non-unitary SL(2, C) representations, SL(4, R) representation regrouping of tonsorial and spinorial fields of an arbitrary spin Lagrangian field theory, as well as its SL(5, R) generalization in the case of infinite-component world spinor and tensor field theories are presented. (author)

  4. On the spinor representation

    Energy Technology Data Exchange (ETDEWEB)

    Hoff da Silva, J.M.; Rogerio, R.J.B. [Universidade Estadual Paulista, Departamento de Fisica e Quimica, Guaratingueta, SP (Brazil); Villalobos, C.H.C. [Universidade Estadual Paulista, Departamento de Fisica e Quimica, Guaratingueta, SP (Brazil); Universidade Federal Fluminense, Instituto de Fisica, Niteroi, RJ (Brazil); Rocha, Roldao da [Universidade Federal do ABC-UFABC, Centro de Matematica, Computacao e Cognicao, Santo Andre (Brazil)

    2017-07-15

    A systematic study of the spinor representation by means of the fermionic physical space is accomplished and implemented. The spinor representation space is shown to be constrained by the Fierz-Pauli-Kofink identities among the spinor bilinear covariants. A robust geometric and topological structure can be manifested from the spinor space, wherein the first and second homotopy groups play prominent roles on the underlying physical properties, associated to fermionic fields. The mapping that changes spinor fields classes is then exemplified, in an Einstein-Dirac system that provides the spacetime generated by a fermion. (orig.)

  5. Beyond spinors

    International Nuclear Information System (INIS)

    Rausch Traubenberg, M. de; Fleury, N.

    1988-01-01

    We propose an extension of spinors, called metaspinors, in space with any number of dimensions. Metaspinors are interpreted as a representation of the symmetry group that leaves a given homogeneous forms of degree n invariant. First, we study two kinds of homogeneous forms and the symmetry groups associated. Only one of these allows to define n-metaspinors. We next find two sets of nxn matrices associated with the two previous forms which could be an extension of Pauli matrices. Assuming n-metaspinors to be a n-complex vectorial space with a peculiar n-metric, we also characterize states of metaspinors and introduce the metaspin. From the study of metaspinorial tensors, we prove that they reduce to vectors. From n-metaspinors, if the dimension is n = pk, we can define p-metaspinors. Finally, we give the dynamical evolution of metaspinors, on the classical level with Dirac and Bargmann-Wigner-Like equations and on the quantic one with path integral formulation. At each step of the calculations, when n = 2, metaspinors reproduce the results of ordinary spinors

  6. Classical local U(1 gauge invariance in Weyl 2-spinor lenguage and charge quantization from irreducible representations of the gauge group

    Directory of Open Access Journals (Sweden)

    J. Buitrago

    Full Text Available A new classical 2-spinor approach to U(1 gauge theory is presented in which the usual four-potential vector field is replaced by a symmetric second rank spinor. Following a lagrangian formulation, it is shown that the four-rank spinor representing the Maxwell field tensor has a U(1 local gauge invariance in terms of the electric and magnetic field strengths. When applied to the magnetic field of a monopole, this formulation, via the irreducible representation condition for the gauge group, leads to a quantization condition differing by a factor 2 of the one predicted by Dirac without relying on any kind of singular vector potentials. Finally, the U(1 invariant spinor equations, are applied to electron magnetic resonance which has many applications in the study of materials. Keywords: Weyl 2-spinor lenguage, Dirac equation, Gauge theories, Charge quantization

  7. Some double-valued representations of the linear groups

    International Nuclear Information System (INIS)

    Ne'eman, Y.

    1983-01-01

    We review the mathematical theory of SL(n,R) and its double-covering group anti SL(n,R), especially for n = 2, 3, 4. After discussing a variety of physical applications, we show that anti SL(3,R) provides holonomic curved space (world) spinors with an infinite number of components. We construct the relevant holononic manifield and discuss the gravitational interaction of a proton as an example. 41 references

  8. Non-critical pure spinor superstrings

    International Nuclear Information System (INIS)

    Adam, Ido; Grassi, Pietro Antonio; Mazzucato, Luca; Oz, Yaron; Yankielowicz, Shimon

    2007-01-01

    We construct non-critical pure spinor superstrings in two, four and six dimensions. We find explicitly the map between the RNS variables and the pure spinor ones in the linear dilaton background. The RNS variables map onto a patch of the pure spinor space and the holomorphic top form on the pure spinor space is an essential ingredient of the mapping. A basic feature of the map is the requirement of doubling the superspace, which we analyze in detail. We study the structure of the non-critical pure spinor space, which is different from the ten-dimensional one, and its quantum anomalies. We compute the pure spinor lowest lying BRST cohomology and find an agreement with the RNS spectra. The analysis is generalized to curved backgrounds and we construct as an example the non-critical pure spinor type IIA superstring on AdS 4 with RR 4-form flux

  9. On pure spinor formalism for quantum superstring and spinor moving frame

    International Nuclear Information System (INIS)

    Bandos, Igor A

    2013-01-01

    The D = 10 pure spinor constraint can be solved in terms of spinor moving frame variables v -α q and eight-component complex null vector Λ + q , Λ + q Λ + q =0, which can be related to the κ-symmetry ghost. Using this and similar solutions for the conjugate pure spinor and other elements of the non-minimal pure spinor formalism, we present a (hopefully useful) reformulation of the measure of the pure spinor path integral for superstring in terms of products of Cartan forms corresponding to the coset of 10D Lorentz group and to the coset of complex orthogonal group SO(8, C). Our study suggests a possible complete reformulation of the pure spinor superstring in terms of new irreducible set of variable. (paper)

  10. Clifford Algebras and Spinors

    International Nuclear Information System (INIS)

    Todorov, Ivan

    2010-12-01

    Expository notes on Clifford algebras and spinors with a detailed discussion of Majorana, Weyl, and Dirac spinors. The paper is meant as a review of background material, needed, in particular, in now fashionable theoretical speculations on neutrino masses. It has a more mathematical flavour than the over twenty-six-year-old Introduction to Majorana masses [M84] and includes historical notes and biographical data on past participants in the story. (author)

  11. A visual description of 2-component spinor calculus

    International Nuclear Information System (INIS)

    Hellsten, H.

    1975-07-01

    Spinors and algebraic operations on them are given a visual description. This structural interpretation of spinors is to be contrasted with the well known quadratic relation between spinors and visual objects (vectors,flagpoles). The interpretation in the present paper is founded on the observation that the product between two successive rotations half a turn along the legs of an angle will be a rotation through twice that angle. This observation makes it possible to explain visually the doubling of angles, which occurs when vectors are constructed out of spinors. It is seen that, using this explanation, spinor calculus can, in close analogy to 3-dimensional Euclidean vector calculus, be given a purely visual meaning. (Auth.)

  12. Spinor structures on homogeneous spaces

    International Nuclear Information System (INIS)

    Lyakhovskii, V.D.; Mudrov, A.I.

    1993-01-01

    For multidimensional models of the interaction of elementary particles, the problem of constructing and classifying spinor fields on homogeneous spaces is exceptionally important. An algebraic criterion for the existence of spinor structures on homogeneous spaces used in multidimensional models is developed. A method of explicit construction of spinor structures is proposed, and its effectiveness is demonstrated in examples. The results are of particular importance for harmonic decomposition of spinor fields

  13. Spinor Structure and Internal Symmetries

    Science.gov (United States)

    Varlamov, V. V.

    2015-10-01

    Spinor structure and internal symmetries are considered within one theoretical framework based on the generalized spin and abstract Hilbert space. Complex momentum is understood as a generating kernel of the underlying spinor structure. It is shown that tensor products of biquaternion algebras are associated with the each irreducible representation of the Lorentz group. Space-time discrete symmetries P, T and their combination PT are generated by the fundamental automorphisms of this algebraic background (Clifford algebras). Charge conjugation C is presented by a pseudoautomorphism of the complex Clifford algebra. This description of the operation C allows one to distinguish charged and neutral particles including particle-antiparticle interchange and truly neutral particles. Spin and charge multiplets, based on the interlocking representations of the Lorentz group, are introduced. A central point of the work is a correspondence between Wigner definition of elementary particle as an irreducible representation of the Poincaré group and SU(3)-description (quark scheme) of the particle as a vector of the supermultiplet (irreducible representation of SU(3)). This correspondence is realized on the ground of a spin-charge Hilbert space. Basic hadron supermultiplets of SU(3)-theory (baryon octet and two meson octets) are studied in this framework. It is shown that quark phenomenologies are naturally incorporated into presented scheme. The relationship between mass and spin is established. The introduced spin-mass formula and its combination with Gell-Mann-Okubo mass formula allows one to take a new look at the problem of mass spectrum of elementary particles.

  14. On the bosonization of the massless spinor electrodynamics

    International Nuclear Information System (INIS)

    Mikhov, S.G.; Stoyanov, D.Ts.

    1979-01-01

    A method for constructing a field transformed according to a linear representation of a Lie group out of fields transformed nonlinearly under the action of the same group is proposed. This procedure is used in order to construct spinor fields out of tensor ones. Such a ''bosonization'' of the spinor field is used to reformulate the massless spinor electrodynamics in terms of nonlinear tensor fields. It appears in this formulation that the Dirac equation is reduced to a definition of the electromagnetic vector potential in terms of the nonlinear tensor fields and to the current conservations playing the role of a consistency condition for this formulation

  15. Spinor formalism and complex-vector formalism of general relativity

    International Nuclear Information System (INIS)

    Han-ying, G.; Yong-shi, W.; Gendao, L.

    1974-01-01

    In this paper, using E. Cartan's exterior calculus, we give the spinor form of the structure equations, which leads naturally to the Newman--Penrose equations. Furthermore, starting from the spinor spaces and the el (2C) algebra, we construct the general complex-vector formalism of general relativity. We find that both the Cahen--Debever--Defrise complex-vector formalism and that of Brans are its special cases. Thus, the spinor formalism and the complex-vector formalism of general relativity are unified on the basis of the uni-modular group SL(2C) and its Lie algebra

  16. Double supergeometry

    Energy Technology Data Exchange (ETDEWEB)

    Cederwall, Martin [Division for Theoretical Physics, Department of Physics, Chalmers University of Technology,SE 412 96 Gothenburg (Sweden)

    2016-06-27

    A geometry of superspace corresponding to double field theory is developed, with type I I supergravity in D=10 as the main example. The formalism is based on an orthosymplectic extension OSp(d,d|2s) of the continuous T-duality group. Covariance under generalised super-diffeomorphisms is manifest. Ordinary superspace is obtained as a solution of the orthosymplectic section condition. A systematic study of curved superspace Bianchi identities is performed, and a relation to a double pure spinor superfield cohomology is established. A Ramond-Ramond superfield is constructed as an infinite-dimensional orthosymplectic spinor. Such objects in minimal orbits under the OSp supergroup (“pure spinors”) define super-sections.

  17. Invariant Killing spinors in 11D and type II supergravities

    International Nuclear Information System (INIS)

    Gran, U; Gutowski, J; Papadopoulos, G

    2009-01-01

    We present all isotropy groups and associated Σ groups, up to discrete identifications of the component connected to the identity, of spinors of 11-dimensional and type II supergravities. The Σ groups are products of a Spin group and an R-symmetry group of a suitable lower dimensional supergravity theory. Using the case of SU(4)-invariant spinors as a paradigm, we demonstrate that the Σ groups, and so the R-symmetry groups of lower dimensional supergravity theories arising from compactifications, have disconnected components. These lead us to discrete symmetry groups reminiscent of R-parity. We examine the role of disconnected components of the Σ groups in the choice of Killing spinor representatives and in the context of compactifications.

  18. The naked spinor a rewrite of Clifford algebra

    CERN Document Server

    Morris, Dennis

    2015-01-01

    This book is about spinors. The whole mathematical theory of spinors is within Clifford algebra, and so this book is about Clifford algebra. Spinor theory is really the theory of empty space, and so this book is about empty space. The whole of Clifford algebra is rewritten in a much simpler form, and so the whole of spinor theory is rewritten in a much simpler form. Not only does this book make Clifford algebra simple and obvious, but it lifts the fog and mirrors from this area of mathematics to make it clear and obvious. In doing so, the true nature of spinors is revealed to the reader, and, with that, the true nature of empty space. To understand this book you will need an elementary knowledge of linear algebra (matrices) an elementary knowledge of finite groups and an elementary knowledge of the complex numbers. From no more than that, you will gain a very deep understanding of Clifford algebra, spinors, and empty space. The book is well written with all the mathematical steps laid before the reader in a w...

  19. Some remarks on spinor particle pair creation in alternating homogeneous external field

    International Nuclear Information System (INIS)

    Perelomov, A.M.

    1975-01-01

    It is shown that the dynamical symmetry group of the problem of spinor particle pair creation in alternating homogeneous external fields is the SO(5) group. The probability of pair creation is given by the modulus square of the matrix element of spinor representation of this group. (Auth.)

  20. Projector bases and algebraic spinors

    International Nuclear Information System (INIS)

    Bergdolt, G.

    1988-01-01

    In the case of complex Clifford algebras a basis is constructed whose elements satisfy projector relations. The relations are sufficient conditions for the elements to span minimal ideals and hence to define algebraic spinors

  1. Molecular orbital theory. Spinor representation

    International Nuclear Information System (INIS)

    Aono, Shigeyuki

    2003-01-01

    The algebra representing electron is spinor. The many electron problem is investigated with the Nambu 2x2 spinor. Operators then are expressed 2x2 matrices. The electron-electron interaction is decomposed into couplings between various electron densities by using the Pauli spin matrices. The diagonal ones of them refer to the direct and exchange interactions and the off-diagonal terms to those for superconducting. The Roothaan theory is rewritten. The approximation beyond the Hartree-Fock is discussed. (author)

  2. Spinor pregeometry at finite temperature

    International Nuclear Information System (INIS)

    Yoshimoto, Seiji.

    1985-10-01

    We derive the effective action for gravity at finite temperature in spinor pregeometry. The temperature-dependent effective potential for the vierbein which is parametrized as e sub(kμ) = b.diag(1, xi, xi, xi) has the minimum at b = 0 for fixed xi, and behaves as -xi 3 for fixed b. These results indicate that the system of fundamental matters in spinor pregeometry cannot be in equilibrium. (author)

  3. New spinor fields classes and applications

    Science.gov (United States)

    da Rocha, Roldao

    2017-01-01

    After revisiting the well-known Lounesto classification of spinor fields, wherefrom the bilinear covariants are considered as the landmark beyond Wigner classification, relevant features of regular and singular spinor fields are presented. Hence, non-standard spinor fields are scrutinised, together with their associated dynamics, paving recently found applications in Physics. The case of the new classes of spinors on 7-manifolds is revisited to provide concrete examples.

  4. Complex group algebras of the double covers of the symmetric and alternating group

    DEFF Research Database (Denmark)

    Bessenrodt, Christine; Nguyen, Hung Ngoc; Olsson, Jørn Børling

    2015-01-01

    We prove that the double covers of the alternating and symmetric groups are determined by their complex group algebras......We prove that the double covers of the alternating and symmetric groups are determined by their complex group algebras...

  5. Experimental demonstration of spinor slow light

    Science.gov (United States)

    Lee, Meng-Jung; Ruseckas, Julius; Lee, Chin-Yuan; Kudriašov, Viačeslav; Chang, Kao-Fang; Cho, Hung-Wen; JuzeliÅ«nas, Gediminas; Yu, Ite A.

    2016-03-01

    Over the last decade there has been a continuing interest in slow and stored light based on the electromagnetically induced transparency (EIT) effect, because of their potential applications in quantum information manipulation. However, previous experimental works all dealt with the single-component slow light which cannot be employed as a qubit. In this work, we report the first experimental demonstration of two-component or spinor slow light (SSL) using a double tripod (DT) atom-light coupling scheme. The oscillations between the two components, similar to the Rabi oscillation of a two-level system or a qubit, were observed. Single-photon SSL can be considered as two-color qubits. We experimentally demonstrated a possible application of the DT scheme as quantum memory and quantum rotator for the two-color qubits. This work opens up a new direction in the slow light research.

  6. Algebraic and Dirac-Hestenes spinors and spinor fields

    International Nuclear Information System (INIS)

    Rodrigues, Waldyr A. Jr.

    2004-01-01

    Almost all presentations of Dirac theory in first or second quantization in physics (and mathematics) textbooks make use of covariant Dirac spinor fields. An exception is the presentation of that theory (first quantization) offered originally by Hestenes and now used by many authors. There, a new concept of spinor field (as a sum of nonhomogeneous even multivectors fields) is used. However, a careful analysis (detailed below) shows that the original Hestenes definition cannot be correct since it conflicts with the meaning of the Fierz identities. In this paper we start a program dedicated to the examination of the mathematical and physical basis for a comprehensive definition of the objects used by Hestenes. In order to do that we give a preliminary definition of algebraic spinor fields (ASF) and Dirac-Hestenes spinor fields (DHSF) on Minkowski space-time as some equivalence classes of pairs (Ξ u ,ψ Ξ u ), where Ξ u is a spinorial frame field and ψ Ξ u is an appropriate sum of multivectors fields (to be specified below). The necessity of our definitions are shown by a careful analysis of possible formulations of Dirac theory and the meaning of the set of Fierz identities associated with the bilinear covariants (on Minkowski space-time) made with ASF or DHSF. We believe that the present paper clarifies some misunderstandings (past and recent) appearing on the literature of the subject. It will be followed by a sequel paper where definitive definitions of ASF and DHSF are given as appropriate sections of a vector bundle called the left spin-Clifford bundle. The bundle formulation is essential in order to be possible to produce a coherent theory for the covariant derivatives of these fields on arbitrary Riemann-Cartan space-times. The present paper contains also Appendixes A-E which exhibits a truly useful collection of results concerning the theory of Clifford algebras (including many tricks of the trade) necessary for the intelligibility of the text

  7. Dipolar and spinor bosonic systems

    Science.gov (United States)

    Yukalov, V. I.

    2018-05-01

    The main properties and methods of describing dipolar and spinor atomic systems, composed of bosonic atoms or molecules, are reviewed. The general approach for the correct treatment of Bose-condensed atomic systems with nonlocal interaction potentials is explained. The approach is applied to Bose-condensed systems with dipolar interaction potentials. The properties of systems with spinor interaction potentials are described. Trapped atoms and atoms in optical lattices are considered. Effective spin Hamiltonians for atoms in optical lattices are derived. The possibility of spintronics with cold atom is emphasized. The present review differs from the previous review articles by concentrating on a thorough presentation of basic theoretical points, helping the reader to better follow mathematical details and to make clearer physical conclusions.

  8. Phantom metrics with Killing spinors

    Directory of Open Access Journals (Sweden)

    W.A. Sabra

    2015-11-01

    Full Text Available We study metric solutions of Einstein–anti-Maxwell theory admitting Killing spinors. The analogue of the IWP metric which admits a space-like Killing vector is found and is expressed in terms of a complex function satisfying the wave equation in flat (2+1-dimensional space–time. As examples, electric and magnetic Kasner spaces are constructed by allowing the solution to depend only on the time coordinate. Euclidean solutions are also presented.

  9. Fundamentals of the Pure Spinor Formalism

    CERN Document Server

    Hoogeveen, Joost

    2010-01-01

    This thesis presents recent developments within the pure spinor formalism, which has simplified amplitude computations in perturbative string theory, especially when spacetime fermions are involved. Firstly the worldsheet action of both the minimal and the non-minimal pure spinor formalism is derived from first principles, i.e. from an action with two dimensional diffeomorphism and Weyl invariance. Secondly the decoupling of unphysical states in the minimal pure spinor formalism is proved

  10. Symmetry and exact solutions of nonlinear spinor equations

    International Nuclear Information System (INIS)

    Fushchich, W.I.; Zhdanov, R.Z.

    1989-01-01

    This review is devoted to the application of algebraic-theoretical methods to the problem of constructing exact solutions of the many-dimensional nonlinear systems of partial differential equations for spinor, vector and scalar fields widely used in quantum field theory. Large classes of nonlinear spinor equations invariant under the Poincare group P(1, 3), Weyl group (i.e. Poincare group supplemented by a group of scale transformations), and the conformal group C(1, 3) are described. Ansaetze invariant under the Poincare and the Weyl groups are constructed. Using these we reduce the Poincare-invariant nonlinear Dirac equations to systems of ordinary differential equations and construct large families of exact solutions of the nonlinear Dirac-Heisenberg equation depending on arbitrary parameters and functions. In a similar way we have obtained new families of exact solutions of the nonlinear Maxwell-Dirac and Klein-Gordon-Dirac equations. The obtained solutions can be used for quantization of nonlinear equations. (orig.)

  11. Spinor calculus on 5-dimensional spacetimes

    International Nuclear Information System (INIS)

    Gomez-Lobo, Alfonso Garcia-Parrado; Martin-Garcia, Jose M

    2010-01-01

    We explain how Penrose's spinor calculus of 4-dimensional Lorentzian geometry is implemented in a 5-dimensional Lorentzian manifold. A number of issues, such as the essential spin algebra, the spin covariant derivative and the algebro-differential properties of the curvature spinors are discussed.

  12. Spinors in Hilbert Space

    Science.gov (United States)

    Plymen, Roger; Robinson, Paul

    1995-01-01

    Infinite-dimensional Clifford algebras and their Fock representations originated in the quantum mechanical study of electrons. In this book, the authors give a definitive account of the various Clifford algebras over a real Hilbert space and of their Fock representations. A careful consideration of the latter's transformation properties under Bogoliubov automorphisms leads to the restricted orthogonal group. From there, a study of inner Bogoliubov automorphisms enables the authors to construct infinite-dimensional spin groups. Apart from assuming a basic background in functional analysis and operator algebras, the presentation is self-contained with complete proofs, many of which offer a fresh perspective on the subject.

  13. Solutions to Yang-Baxter equation for the spinor representations of q-Bl

    International Nuclear Information System (INIS)

    Hou Boyuan; Ma Zhongqi.

    1990-10-01

    In this paper, both trigonometric and rational solutions to the Yang-Baxter equation associated with the spinor representations of the quantum B l universal enveloping algebras are obtained. The corresponding representations of the braid group and the link polynomials are also computed through a standard method. The quantum Clebsch-Gordan matrix, the quantum projectors and the solutions associated with the spinor representation of the quantum B 3 are presented explicitly. (author). 16 refs, 2 tabs

  14. All-optical spinor Bose-Einstein condensation and the spinor dynamics-driven atom laser

    Science.gov (United States)

    Lundblad, Nathan Eric

    Optical trapping as a viable means of exploring the physics of ultracold dilute atomic gases has revealed a new spectrum of physical phenomena. In particular, macroscopic and sudden occupation of the ground state below a critical temperature---a phenomenon known as Bose-Einstein condensation---has become an even richer system for the study of quantum mechanics, ultracold collisions, and many-body physics in general. Optical trapping liberates the spin degree of the BEC, making the order parameter vectorial ('spinor BEC'), as opposed to the scalar order of traditional magnetically trapped condensates. The work described within is divided into two main efforts. The first encompasses the all-optical creation of a Bose-Einstein condensate in rubidium vapor. An all-optical path to spinor BEC (as opposed to transfer to an optical trap from a magnetic trap condensate) was desired both for the simplicity of the experimental setup and also for the potential gains in speed of creation; evaporative cooling, the only known path to dilute-gas condensation, works only as efficiently as the rate of elastic collisions in the gas, a rate that starts out much higher in optical traps. The first all-optical BEC was formed elsewhere in 2001; the years following saw many groups worldwide seeking to create their own version. Our own all-optical spinor BEC, made with a single-beam dipole trap formed by a focused CO2 laser, is described here, with particular attention paid to trap loading, measurement of trap parameters, and the use of a novel 780 nm high-power laser system. The second part describes initial experiments performed with the nascent condensate. The spinor properties of the condensate are documented, and a measurement is made of the density-dependent rate of spin mixing in the condensate. In addition, we demonstrate a novel dual-beam atom laser formed by outcoupling oppositely polarized components of the condensate, whose populations have been coherently evolved through spin

  15. Four forces and spinor connection in general relativity

    International Nuclear Information System (INIS)

    Lynch, J.T.

    1985-01-01

    This work is an extension of the recent spinor-connection theory of Szekeres, Cullinan, and Lynch. In that theory, a geometric model for the gravitational and electromagnetic fields was realized by use of both left- and right-connection groups acting on a 4 x 4 spinor tetrad. Here the right-connection group is enlarged in a natural way from a one-parameter to a three-parameter Lie group. This enlargement introduces two extra potential fields which may provide a simple model for the strong and weak fields in curved space-time. A solution to the new field equations is given for a neutral ''pionlike'' particle exhibiting the strong and gravitational fields

  16. Black Holes and Exotic Spinors

    Directory of Open Access Journals (Sweden)

    J. M. Hoff da Silva

    2016-05-01

    Full Text Available Exotic spin structures are non-trivial liftings, of the orthogonal bundle to the spin bundle, on orientable manifolds that admit spin structures according to the celebrated Geroch theorem. Exotic spin structures play a role of paramount importance in different areas of physics, from quantum field theory, in particular at Planck length scales, to gravity, and in cosmological scales. Here, we introduce an in-depth panorama in this field, providing black hole physics as the fount of spacetime exoticness. Black holes are then studied as the generators of a non-trivial topology that also can correspond to some inequivalent spin structure. Moreover, we investigate exotic spinor fields in this context and the way exotic spinor fields branch new physics. We also calculate the tunneling probability of exotic fermions across a Kerr-Sen black hole, showing that the exotic term does affect the tunneling probability, altering the black hole evaporation rate. Finally we show that it complies with the Hawking temperature universal law.

  17. Pure spinor integration from the collating formula

    International Nuclear Information System (INIS)

    Grassi, P.A.; Sommovigo, L.

    2011-01-01

    We use the technique developed by Becchi and Imbimbo to construct a well-defined BRST-invariant path integral formulation of pure spinor amplitudes. The space of pure spinors can be viewed from the algebraic geometry point of view as a collection of open sets where the constraints can be solved and a set of free and independent variables can be defined. On the intersections of those open sets, the functional measure jumps and one has to add boundary terms to construct a well-defined path integral. The result is the definition of the pure spinor integration measure constructed in terms of differential forms on each single patch.

  18. Timelike Killing spinors in seven dimensions

    International Nuclear Information System (INIS)

    Cariglia, Marco; Conamhna, Oisin A.P. Mac

    2004-01-01

    We employ the G-structure formalism to study supersymmetric solutions of minimal and SU(2) gauged supergravities in seven dimensions admitting Killing spinors with an associated timelike Killing vector. The most general such Killing spinor defines a SU(3) structure. We deduce necessary and sufficient conditions for the existence of a timelike Killing spinor on the bosonic fields of the theories, and find that such configurations generically preserve one out of 16 supersymmetries. Using our general supersymmetric ansatz we obtain numerous new solutions, including squashed or deformed anti-de Sitter solutions of the gauged theory, and a large class of Goedel-like solutions with closed timelike curves

  19. Some basic properties of Killing spinors

    International Nuclear Information System (INIS)

    Hacyan, S.; Plebanski, J.

    1976-01-01

    The concept of Killing spinor is analyzed in a general way by using the spinorial formalism. It is shown, among other things, that higher derivatives of Killing spinors can be expressed in terms of lower order derivatives. Conformal Killing vectors are studied in some detail in the light of spinorial analysis: Classical results are formulated in terms of spinors. A theorem on Lie derivatives of Debever--Penrose vectors is proved, and it is shown that conformal motion in vacuum with zero cosmological constant must be homothetic, unless the conformal tensor vanishes or is of type N. Our results are valid for either real or complex space--time manifolds

  20. Anti-ferromagnetic spinor BECs in optical lattices

    Energy Technology Data Exchange (ETDEWEB)

    Rossini, Davide [NEST-CNR-INFM and Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy); Rizzi, Matteo [NEST-CNR-INFM and Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy); Chiara, Gabriele De [NEST-CNR-INFM and Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy); Montangero, Simone [NEST-CNR-INFM and Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy); Fazio, Rosario [NEST-CNR-INFM and Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy); International School for Advanced Studies SISSA/ISAS, via Beirut 2-4, I-34014 Trieste (Italy)

    2006-05-28

    Spinor Bose condensates loaded in optical lattices have a rich phase diagram characterized by different magnetic order. In this work we evaluated the phase boundary between the Mott insulator and the superfluid phase by means of the density matrix renormalization group. Furthermore, we studied the properties of the insulating phase for odd fillings. The results obtained in this work are also relevant for the determination of the ground state phase diagram of the S = 1 Heisenberg model with biquadratic interaction.

  1. Spinors and supersymmetry in four-dimensional Euclidean space

    International Nuclear Information System (INIS)

    McKeon, D.G.C.; Sherry, T.N.

    2001-01-01

    Spinors in four-dimensional Euclidean space are treated using the decomposition of the Euclidean space SO(4) symmetry group into SU(2)xSU(2). Both 2- and 4-spinor representations of this SO(4) symmetry group are shown to differ significantly from the corresponding spinor representations of the SO(3, 1) symmetry group in Minkowski space. The simplest self conjugate supersymmetry algebra allowed in four-dimensional Euclidean space is demonstrated to be an N=2 supersymmetry algebra which resembles the N=2 supersymmetry algebra in four-dimensional Minkowski space. The differences between the two supersymmetry algebras gives rise to different representations; in particular an analysis of the Clifford algebra structure shows that the momentum invariant is bounded above by the central charges in 4dE, while in 4dM the central charges bound the momentum invariant from below. Dimensional reduction of the N=1 SUSY algebra in six-dimensional Minkowski space (6dM) to 4dE reproduces our SUSY algebra in 4dE. This dimensional reduction can be used to introduce additional generators into the SUSY algebra in 4dE. Well known interpolating maps are used to relate the N=2 SUSY algebra in 4dE derived in this paper to the N=2 SUSY algebra in 4dM. The nature of the spinors in 4dE allows us to write an axially gauge invariant model which is shown to be both Hermitian and anomaly-free. No equivalent model exists in 4dM. Useful formulae in 4dE are collected together in two appendixes

  2. Dirac operators and Killing spinors with torsion

    International Nuclear Information System (INIS)

    Becker-Bender, Julia

    2012-01-01

    On a Riemannian spin manifold with parallel skew torsion, we use the twistor operator to obtain an eigenvalue estimate for the Dirac operator with torsion. We consider the equality case in dimensions four and six. In odd dimensions we describe Sasaki manifolds on which equality in the estimate is realized by Killing spinors with torsion. In dimension five we characterize all Killing spinors with torsion and obtain certain naturally reductive spaces as exceptional cases.

  3. Pure spinor partition function and the massive superstring spectrum

    International Nuclear Information System (INIS)

    Aisaka, Yuri; Arroyo, E. Aldo; Berkovits, Nathan; Nekrasov, Nikita

    2008-01-01

    We explicitly compute up to the fifth mass-level the partition function of ten-dimensional pure spinor worldsheet variables including the spin dependence. After adding the contribution from the (x μ , θ α , p α ) matter variables, we reproduce the massive superstring spectrum. Even though pure spinor variables are bosonic, the pure spinor partition function contains fermionic states which first appear at the second mass-level. These fermionic states come from functions which are not globally defined in pure spinor space, and are related to the b ghost in the pure spinor formalism. This result clarifies the proper definition of the Hilbert space for pure spinor variables.

  4. On ''conformal spinor geometry'': An attempt to ''understand'' internal symmetry

    International Nuclear Information System (INIS)

    Budinich, P.

    1982-01-01

    The natural homomorphism of pure spinors corresponding to a given Clifford algebra Csub(2n) to polarized isotropic n-planes of complex Euclidean space Esub(2n)sup(c) is taken as a starting point for the construction of a geometry called spinor geometry where pure spinors are the only elements out of which all tensors have to be constructed (analytically as bilinear polynomials of the components of a pure spinor). C 4 and C 6 spinor geometry are analyzed, but it seems that C 8 spinor geometry is necessary to construct Minkowski space Msup(3,1). C 6 spinor field equations give rise in Minkowski space to a pair of Dirac equations (for conformal semispinors) presenting an su(2) internal symmetry algebra. Mass is generated by breaking spontaneously the original O(4,2) symmetry of the spinor equation. (author)

  5. On ''conformal spinor geometry'': An attempt to ''understand'' internal symmetry

    International Nuclear Information System (INIS)

    Budinich, P.

    1981-09-01

    The natural homomorphism of pure spinors corresponding to a given Clifford algebra Csub(2n) to polarized isotropic n-planes of complex Euclidean space Esub(2n)sup(c) is taken as a starting point for the construction of a geometry called spinor geometry where pure spinors are the only elements out of which all tensors have to be constructed (analytically as bilinear polynomia of the components of a pure spinor). C 4 and C 6 spinor geometry are analyzed but it seems that C 8 spinor geometry is necessary to construct Minkowski space Msup(3,1). C 6 spinor field equations give rise in Minkowski space to a pair of Dirac equations (for conformal semispinors) presenting an SU(2) internal symmetry algebra. Mass is generated by spontaneously breaking the original O(4,2) symmetry of the spinor equation. (author)

  6. Unfolding physics from the algebraic classification of spinor fields

    International Nuclear Information System (INIS)

    Hoff da Silva, J.M.; Rocha, Roldão da

    2013-01-01

    After reviewing the Lounesto spinor field classification, according to the bilinear covariants associated to a spinor field, we call attention and unravel some prominent features involving unexpected properties about spinor fields under such classification. In particular, we pithily focus on the new aspects — as well as current concrete possibilities. They mainly arise when we deal with some non-standard spinor fields concerning, in particular, their applications in physics.

  7. Spinors, tensors and the covariant form of Dirac's equation

    International Nuclear Information System (INIS)

    Chen, W.Q.; Cook, A.H.

    1986-01-01

    The relations between tensors and spinors are used to establish the form of the covariant derivative of a spinor, making use of the fact that certain bilinear combinations of spinors are vectors. The covariant forms of Dirac's equation are thus obtained and examples in specific coordinate systems are displayed. (author)

  8. An introduction to Clifford algebras and spinors

    CERN Document Server

    Vaz, Jayme

    2016-01-01

    This text explores how Clifford algebras and spinors have been sparking a collaboration and bridging a gap between Physics and Mathematics. This collaboration has been the consequence of a growing awareness of the importance of algebraic and geometric properties in many physical phenomena, and of the discovery of common ground through various touch points: relating Clifford algebras and the arising geometry to so-called spinors, and to their three definitions (both from the mathematical and physical viewpoint). The main point of contact are the representations of Clifford algebras and the periodicity theorems. Clifford algebras also constitute a highly intuitive formalism, having an intimate relationship to quantum field theory. The text strives to seamlessly combine these various viewpoints and is devoted to a wider audience of both physicists and mathematicians. Among the existing approaches to Clifford algebras and spinors this book is unique in that it provides a didactical presentation of the topic and i...

  9. Topological M Theory from Pure Spinor Formalism

    CERN Document Server

    Grassi, P A; Grassi, Pietro Antonio; Vanhove, Pierre

    2005-01-01

    We construct multiloop superparticle amplitudes in 11d using the pure spinor formalism. We explain how this construction reduces to the superparticle limit of the multiloop pure spinor superstring amplitudes prescription. We then argue that this construction points to some evidence for the existence of a topological M theory based on a relation between the ghost number of the full-fledged supersymmetric critical models and the dimension of the spacetime for topological models. In particular, we show that the extensions at higher orders of the previous results for the tree and one-loop level expansion for the superparticle in 11 dimensions is related to a topological model in 7 dimensions.

  10. Spinor exchange in AdSd+1

    International Nuclear Information System (INIS)

    Kawano, Teruhiko; Okuyama, Kazumi

    2000-01-01

    We explicitly calculate a Witten diagram with general spinor field exchange on (d+1)-dimensional Euclidean Anti-de Sitter space, which is necessary to evaluate four-point correlation functions with spinor fields when we make use of the AdS/CFT correspondence, especially in supersymmetric cases. We also show that the amplitude can be reduced to a scalar exchange amplitude. We discuss the operator product expansion of the dual conformal field theory by interpreting the short distance expansion of the amplitude according to the AdS/CFT correspondence

  11. Pure spinors as auxiliary fields in the ten-dimensional supersymmetric Yang-Mills theory

    International Nuclear Information System (INIS)

    Nilsson, B.E.W.

    1986-01-01

    A new way of introducing auxiliary fields into the ten-dimensional supersymmetric Yang-Mills theory is proposed. The auxiliary fields are commuting 'pure spinors' and constitute a non-linear realisation of the Lorentz group. This invalidates previous no-go theorems concerning the possibility of going off-shell in this theory. There seems to be a close relation between pure spinors and the concepts usually used in twistor theory. The non-Abelian theory can be constructed for all groups having pseudo-real representations. (author)

  12. Spinor approach to gravitational motion and precession

    International Nuclear Information System (INIS)

    Hestenes, D.

    1986-01-01

    The translational and rotational equations of motion for a small rigid body in a gravitational field are combined in a single spinor equation. Besides its computational advantages, this unifies the description of gravitational interaction in classical and quantum theory. Explicit expressions for gravitational precession rates are derived. (author)

  13. Double covering of diffeomorphisms for superstrings in generic curved space

    International Nuclear Information System (INIS)

    Ne'eman, Y.; Sijacki, D.

    1986-01-01

    The embedding of the superstring in a generic curved space involves the use of world-spinors behaving according to the (infinite) unitary representations of SL-bar(10,R), the double-covering of the linear group on R 10 . A supersymmetric extrension is provided by the embedding of GL-bar(10,R) in the supergroup GQ-bar(10,R) whose flat limit reproduces Poincare supersymmetry

  14. Geometrical treatment of Clifford algebras and spinors with applications to the dynamics of spin particles

    International Nuclear Information System (INIS)

    Dimakis, A.

    1983-01-01

    The algebraic structure of the real Clifford algebras (CA) of vector spaces with non-degenerated scalar product of arbitrary signature is studied, and a classification formula for this is obtained. The latter is based on three sequences of integer numbers from which one is the Radon-Harwitz sequence. A new representation method of real CA is constructed. This leads to a geometrical representation of real Clifford algebras in which the representation spaces are subspaces of the CA itself (''spinor spaces''). One of these spinor spaces is a subalgebra of the original CA. The relation between CA and external algebras is studied. Each external algebra with a scalar product possesses the structure of a CA. From the geometric representation developed here then follows that spinors are inhomogeneous external forms. The transformation behaviour of spinors under the orthogonal, as well as under the general linear group is studied. By means of these algebraic results the spinor connexion and the covariant Dirac operator on a differential manifold are introduced. In the geometrical representation a further in ternal SL(2,R) symmetry of the Dirac equation (DE) is shown. Furthermore other equivalent formulations of the DE can be obtained. Of special interest is the tetrade formulation of the DE. A generalization of the DE is introduced. The equations of motion of the classical relativistic spin particle are derived by means of spinors and CA from a variational principle. From this interesting formal analogies with the supersymmetric theories of the spin particle result. Finally the DE in the curved space-time is established and studied in the tetrade formulation. Using the methods developed here a new exact solution of the coupled Einstein-Curtan-Dirac theory was found (massice ''Ghost-Dirac fields''). (orig.) [de

  15. Higgs potential and spinor connection within Weinberg-Salam model

    International Nuclear Information System (INIS)

    Trostel, R.

    1987-01-01

    We arrive at a theory of the Higgs potential by extending the usual concept of the covariant derivative containing the gauge fields to one which also contains the Higgs fields, by using a spinor connection compatible under local gauge transformations. Not only the Yukawa couplings are geometrized by this procedure but also the nonlinear Higgs potential naturally appears within the curvature of the corresponding spinor connection. Taking the gauge group to be SU(2) x U(1), we arrive for the leptonic Weinberg Salam model at a Weinberg angle prediction of sin 2 θ=1/4 and at a Higgs mass of about 263-270 GeV without using any supersymmetry argument. Taking the gauge group to be SU(3) C x SU(2) x U(1) the above leptonic result is obtained only if e 2 /g S 2 is sufficiently small, which is approximately true. Working with two independent Higgs doublets we arrive at a Higgs mass sum rule, where two Higgs must have a mass of about 188 GeV. (author)

  16. Black hole attractors and pure spinors

    International Nuclear Information System (INIS)

    Hsu, Jonathan P.; Maloney, Alexander; Tomasiello, Alessandro

    2006-01-01

    We construct black hole attractor solutions for a wide class of N = 2 compactifications. The analysis is carried out in ten dimensions and makes crucial use of pure spinor techniques. This formalism can accommodate non-Kaehler manifolds as well as compactifications with flux, in addition to the usual Calabi-Yau case. At the attractor point, the charges fix the moduli according to Σf k = Im(CΦ), where Φ is a pure spinor of odd (even) chirality in IIB (A). For IIB on a Calabi-Yau, Φ = Ω and the equation reduces to the usual one. Methods in generalized complex geometry can be used to study solutions to the attractor equation

  17. Scattering equations, supergravity integrands, and pure spinors

    Energy Technology Data Exchange (ETDEWEB)

    Adamo, Tim; Casali, Eduardo [Department of Applied Mathematics & Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)

    2015-05-25

    The tree-level S-matrix of type II supergravity can be computed in scattering equation form by correlators in a worldsheet theory analogous to a chiral, infinite tension limit of the pure spinor formalism. By defining a non-minimal version of this theory, we give a prescription for computing correlators on higher genus worldsheets which manifest space-time supersymmetry. These correlators are conjectured to provide the loop integrands of supergravity scattering amplitudes, supported on the scattering equations. We give non-trivial evidence in support of this conjecture at genus one and two with four external states. Throughout, we find a close correspondence with the pure spinor formalism of superstring theory, particularly regarding regulators and zero-mode counting.

  18. Black Hole Attractors and Pure Spinors

    International Nuclear Information System (INIS)

    Hsu, Jonathan P.; Maloney, Alexander; Tomasiello, Alessandro

    2006-01-01

    We construct black hole attractor solutions for a wide class of N = 2 compactifications. The analysis is carried out in ten dimensions and makes crucial use of pure spinor techniques. This formalism can accommodate non-Kaehler manifolds as well as compactifications with flux, in addition to the usual Calabi-Yau case. At the attractor point, the charges fix the moduli according to Σf k = Im(CΦ), where Φ is a pure spinor of odd (even) chirality in IIB (A). For IIB on a Calabi-Yau, Φ = (Omega) and the equation reduces to the usual one. Methods in generalized complex geometry can be used to study solutions to the attractor equation

  19. Scattering equations, supergravity integrands, and pure spinors

    International Nuclear Information System (INIS)

    Adamo, Tim; Casali, Eduardo

    2015-01-01

    The tree-level S-matrix of type II supergravity can be computed in scattering equation form by correlators in a worldsheet theory analogous to a chiral, infinite tension limit of the pure spinor formalism. By defining a non-minimal version of this theory, we give a prescription for computing correlators on higher genus worldsheets which manifest space-time supersymmetry. These correlators are conjectured to provide the loop integrands of supergravity scattering amplitudes, supported on the scattering equations. We give non-trivial evidence in support of this conjecture at genus one and two with four external states. Throughout, we find a close correspondence with the pure spinor formalism of superstring theory, particularly regarding regulators and zero-mode counting.

  20. Antiferromagnetic spinor condensates in a bichromatic superlattice

    Science.gov (United States)

    Tang, Tao; Zhao, Lichao; Chen, Zihe; Liu, Yingmei

    2017-04-01

    A spinor Bose-Einstein condensate in an optical supelattice has been considered as a good quantum simulator for understanding mesoscopic magnetism. We report an experimental study on an antiferromagnetic spinor condensate in a bichromatic superlattice constructed by a cubic red-detuned optical lattice and a one-dimensional blue-detuned optical lattice. Our data demonstrate a few advantages of this bichromatic superlattice over a monochromatic lattice. One distinct advantage is that the bichromatic superlattice enables realizing the first-order superfluid to Mott-insulator phase transitions within a much wider range of magnetic fields. In addition, we discuss an apparent discrepancy between our data and the mean-field theory. We thank the National Science Foundation and the Oklahoma Center for the Advancement of Science and Technology for financial support.

  1. Generalized metric formulation of double field theory on group manifolds

    International Nuclear Information System (INIS)

    Blumenhagen, Ralph; Bosque, Pascal du; Hassler, Falk; Lüst, Dieter

    2015-01-01

    We rewrite the recently derived cubic action of Double Field Theory on group manifolds http://dx.doi.org/10.1007/JHEP02(2015)001 in terms of a generalized metric and extrapolate it to all orders in the fields. For the resulting action, we derive the field equations and state them in terms of a generalized curvature scalar and a generalized Ricci tensor. Compared to the generalized metric formulation of DFT derived from tori, all these quantities receive additional contributions related to the non-trivial background. It is shown that the action is invariant under its generalized diffeomorphisms and 2D-diffeomorphisms. Imposing additional constraints relating the background and fluctuations around it, the precise relation between the proposed generalized metric formulation of DFT WZW and of original DFT from tori is clarified. Furthermore, we show how to relate DFT WZW of the WZW background with the flux formulation of original DFT.

  2. Generalized metric formulation of double field theory on group manifolds

    Energy Technology Data Exchange (ETDEWEB)

    Blumenhagen, Ralph [Max-Planck-Institut für Physik,Föhringer Ring 6, 80805 München (Germany); Bosque, Pascal du [Arnold-Sommerfeld-Center für Theoretische Physik,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany); Hassler, Falk [Max-Planck-Institut für Physik,Föhringer Ring 6, 80805 München (Germany); Lüst, Dieter [Max-Planck-Institut für Physik,Föhringer Ring 6, 80805 München (Germany); Arnold-Sommerfeld-Center für Theoretische Physik,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany); CERN, PH-TH,1211 Geneva 23 (Switzerland)

    2015-08-13

    We rewrite the recently derived cubic action of Double Field Theory on group manifolds http://dx.doi.org/10.1007/JHEP02(2015)001 in terms of a generalized metric and extrapolate it to all orders in the fields. For the resulting action, we derive the field equations and state them in terms of a generalized curvature scalar and a generalized Ricci tensor. Compared to the generalized metric formulation of DFT derived from tori, all these quantities receive additional contributions related to the non-trivial background. It is shown that the action is invariant under its generalized diffeomorphisms and 2D-diffeomorphisms. Imposing additional constraints relating the background and fluctuations around it, the precise relation between the proposed generalized metric formulation of DFT{sub WZW} and of original DFT from tori is clarified. Furthermore, we show how to relate DFT{sub WZW} of the WZW background with the flux formulation of original DFT.

  3. Notes on the ambitwistor pure spinor string

    Czech Academy of Sciences Publication Activity Database

    Lipinski Jusinskas, Renann

    2016-01-01

    Roč. 2016, č. 5 (2016), s. 1-12, č. článku 116. ISSN 1029-8479 R&D Projects: GA ČR GBP201/12/G028 Institutional support: RVO:68378271 Keywords : ambitwistor string * pure spinor formalism Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 6.063, year: 2016

  4. Topological solitons in 8-spinor mie electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Rybakov, Yu. P., E-mail: soliton4@mail.ru [Peoples' Friendship University of Russia, Department of Theoretical Physics (Russian Federation)

    2013-10-15

    We investigate the effective 8-spinor field model suggested earlier as the generalization of nonlinear Mie electrodynamics. We first study in pure spinorial model the existence of topological solitons endowed with the nontrivial Hopf invariant Q{sub H}, which can be interpreted as the lepton number. Electromagnetic field being included as the perturbation, we estimate the energy and the spin of the localized charged configuration.

  5. Quantization of scalar-spinor instanton

    International Nuclear Information System (INIS)

    Inagaki, H.

    1977-04-01

    A systematic quantization to the scalar-spinor instanton is given in a canonical formalism of Euclidean space. A basic idea is in the repair of the symmetries of the 0(5) covariant system in the presence of the instanton. The quantization of the fermion is carried through in such a way that the fermion number should be conserved. Our quantization enables us to get well-defined propagators for both the scalar and the fermion, which are free from unphysical poles

  6. Wigner function for the Dirac oscillator in spinor space

    International Nuclear Information System (INIS)

    Ma Kai; Wang Jianhua; Yuan Yi

    2011-01-01

    The Wigner function for the Dirac oscillator in spinor space is studied in this paper. Firstly, since the Dirac equation is described as a matrix equation in phase space, it is necessary to define the Wigner function as a matrix function in spinor space. Secondly, the matrix form of the Wigner function is proven to support the Dirac equation. Thirdly, by solving the Dirac equation, energy levels and the Wigner function for the Dirac oscillator in spinor space are obtained. (authors)

  7. A formalism for the calculus of variations with spinors

    Energy Technology Data Exchange (ETDEWEB)

    Bäckdahl, Thomas, E-mail: thobac@chalmers.se [The School of Mathematics, University of Edinburgh, JCMB 6228, Peter Guthrie Tait Road, Edinburgh EH9 3FD, United Kingdom and Mathematical Sciences - Chalmers University of Technology and University of Gothenburg - SE-412 96 Gothenburg (Sweden); Valiente Kroon, Juan A., E-mail: j.a.valiente-kroon@qmul.ac.uk [School of Mathematical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS (United Kingdom)

    2016-02-15

    We develop a frame and dyad gauge-independent formalism for the calculus of variations of functionals involving spinorial objects. As a part of this formalism, we define a modified variation operator which absorbs frame and spin dyad gauge terms. This formalism is applicable to both the standard spacetime (i.e., SL(2, ℂ)) 2-spinors as well as to space (i.e., SU(2, ℂ)) 2-spinors. We compute expressions for the variations of the connection and the curvature spinors.

  8. A formalism for the calculus of variations with spinors

    International Nuclear Information System (INIS)

    Bäckdahl, Thomas; Valiente Kroon, Juan A.

    2016-01-01

    We develop a frame and dyad gauge-independent formalism for the calculus of variations of functionals involving spinorial objects. As a part of this formalism, we define a modified variation operator which absorbs frame and spin dyad gauge terms. This formalism is applicable to both the standard spacetime (i.e., SL(2, ℂ)) 2-spinors as well as to space (i.e., SU(2, ℂ)) 2-spinors. We compute expressions for the variations of the connection and the curvature spinors

  9. AdS pure spinor superstring in constant backgrounds

    International Nuclear Information System (INIS)

    Chandia, Osvaldo; Bevilaqua, L. Ibiapina; Vallilo, Brenno Carlini

    2014-01-01

    In this paper we study the pure spinor formulation of the superstring in AdS_5×S"5 around point particle solutions of the classical equations of motion. As a particular example we quantize the pure spinor string in the BMN background

  10. AdS pure spinor superstring in constant backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); Bevilaqua, L. Ibiapina [Escola de Ciências e Tecnologia, Universidade Federal do Rio Grande do Norte,Caixa Postal 1524, 59072-970, Natal, RN (Brazil); Vallilo, Brenno Carlini [Facultad de Ciencias Exactas, Departamento de Ciencias Físicas, Universidad Andres Bello,Republica 220, Santiago (Chile)

    2014-06-05

    In this paper we study the pure spinor formulation of the superstring in AdS{sub 5}×S{sup 5} around point particle solutions of the classical equations of motion. As a particular example we quantize the pure spinor string in the BMN background.

  11. On the bilinear covariants associated to mass dimension one spinors

    Energy Technology Data Exchange (ETDEWEB)

    Silva, J.M.H. da; Villalobos, C.H.C.; Rogerio, R.J.B. [DFQ, UNESP, Guaratingueta, SP (Brazil); Scatena, E. [Universidade Federal de Santa Catarina-CEE, Blumenau, SC (Brazil)

    2016-10-15

    In this paper we approach the issue of Clifford algebra basis deformation, allowing for bilinear covariants associated to Elko spinors which satisfy the Fierz-Pauli-Kofink identities. We present a complete analysis of covariance, taking into account the involved dual structure associated to Elko spinors. Moreover, the possible generalizations to the recently presented new dual structure are performed. (orig.)

  12. Generalized phase transformations of spinor fields

    International Nuclear Information System (INIS)

    Mikhov, S.G.

    1993-09-01

    In this paper some generalized four parameter phase transformations of a Dirac spinor are considered. It is shown that a corresponding compensating transformation of the electromagnetic field which restores the invariance of the Dirac-Maxwell equation might exist, provided some consistency conditions are satisfied by the parameters of the transformations. These transformations are used further to consider the Maxwell equations under the assumption that a Bosonization takes place. Only one of the considered cases proves to have a solution (the other cases show to be trivial) which although unphysical is obtained explicitly. (author). 10 refs

  13. Spinor Slow Light and Two-Color Qubits

    Science.gov (United States)

    Yu, Ite; Lee, Meng-Jung; Ruseckas, Julius; Lee, Chin-Yuan; Kudriasov, Viaceslav; Chang, Kao-Fang; Cho, Hung-Wen; Juzeliunas, Gediminas; Yu, Ite A.

    2015-05-01

    We report the first experimental demonstration of two-component or spinor slow light (SSL) using a double tripod (DT) atom-light coupling scheme. The scheme involves three atomic ground states coupled to two excited states by six light fields. The oscillation due to the interaction between the two components was observed. SSL can be used to achieve high conversion efficiencies in the sum frequency generation and is a better method than the widely-used double- Λ scheme. On the basis of the stored light, our data showed that the DT scheme behaves like the two outcomes of an interferometer enabling precision measurements of frequency detuning. Furthermore, the single-photon SSL can be considered as the qubit with the superposition state of two frequency modes or, simply, as the two-color qubit. We experimentally demonstrated a possible application of the DT scheme as quantum memory/rotator for the two-color qubit. This work opens up a new direction in the EIT/slow light research. yu@phys.nthu.edu.tw

  14. Supersymmetric quantum mechanics, spinors and the standard model

    International Nuclear Information System (INIS)

    Woit, P.

    1988-01-01

    The quantization of the simplest supersymmetric quantum mechanical theory of a free fermion on a riemannian manifold requires the introduction of a complex structure on the tangent space. In 4 dimensions, the subgroup of the group of frame rotations that preserves the complex structure is SU(2) x U(1), and it is argued that this symmetry can be consistently interpreted to be an internal gauge symmetry for the analytically continued theory in Minkowski space. The states of the theory carry the quantum numbers of a generation of leptons in the Weinberg-Salam model. Examination of the geometry of spinors in four dimensions also provides a natural SU(3) symmetry and very simple construction of a multiplet with the standard model quantum numbers. (orig.)

  15. Classical probabilities for Majorana and Weyl spinors

    International Nuclear Information System (INIS)

    Wetterich, C.

    2011-01-01

    Highlights: → Map of classical statistical Ising model to fermionic quantum field theory. → Lattice-regularized real Grassmann functional integral for single Weyl spinor. → Emerging complex structure characteristic for quantum physics. → A classical statistical ensemble describes a quantum theory. - Abstract: We construct a map between the quantum field theory of free Weyl or Majorana fermions and the probability distribution of a classical statistical ensemble for Ising spins or discrete bits. More precisely, a Grassmann functional integral based on a real Grassmann algebra specifies the time evolution of the real wave function q τ (t) for the Ising states τ. The time dependent probability distribution of a generalized Ising model obtains as p τ (t)=q τ 2 (t). The functional integral employs a lattice regularization for single Weyl or Majorana spinors. We further introduce the complex structure characteristic for quantum mechanics. Probability distributions of the Ising model which correspond to one or many propagating fermions are discussed explicitly. Expectation values of observables can be computed equivalently in the classical statistical Ising model or in the quantum field theory for fermions.

  16. On spinor geometry: A genesis of extended supersymmetry

    International Nuclear Information System (INIS)

    Budini, P.

    1980-08-01

    It is conjectured that euclidean geometry should be derived from spinor geometry through the equivalence of simple semispinor with isotropic semi n-vectors. The only tensors of complex 2n dimensional Euclidean space Esub(c)sup(2n) should then be: isotropic n - vectors and their intersections. Esub(c) 4 spinor geometry generates two isotropic semi bivectors equivalent to the semispinors of Esub(c) 4 (their geometrical properties are those of light propagating in vacuum), and their intersection: an isotropic vector (possibly representing momenta of massless particle and/or light rays); but no scalar, pseudoscalar or pseudovector is generated. In order to generate vectors outside the light cone in Msup(3.1) one needs not less than Esub(c) 6 spinor geometry which also generates Lorentz pseudoscalars and non isotropic pseudovectors and tensors. Besides, Dirac spinor should then always appear in doublets in Msup(3.1). Furthermore the mere geometrical structure of Esub(c) 6 spinor geometry seems to suggest formally, both Poincare (extended) and conformal supersymmetry. The suggested spinor-geometrical approach privileges the elementary role of semispinors. Its relevance for the real world should be manifested by the privileged role of semispinors in elementary interactions as in fact seems to be the case with Lorentz semispinors in weak interactions (and could perhaps also be the case for strong ones where conformal semispinors (or twistors) could be the interacting spinor fields). (author)

  17. How to generate spinor representations in any dimension in terms of projection and nilpotent operators

    International Nuclear Information System (INIS)

    Borstnik, N. Mankoc; Nielsen, H.B.

    2002-01-01

    We present a technique to construct a spinor space basis as products of certain nilpotents and projections formed from γ a for which we only need to know that they obey the Clifford algebra. The technique works for all dimensions and signatures. We use this technique to deliver a concrete choice of γ-matrices and Lorentz group generators for (fundamental representations of) spinors in a rather systematic and transparent way. We further develop the formalism by proposing the corresponding graphic presentation of basic states, which offers an easy way to see all the quantum numbers of states with respect to the generators of the Lorentz group, as well as transformation properties of the states under any element of the Clifford algebra

  18. Cohomology in the Pure Spinor Formalism for the Superstring

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2000-01-01

    A manifestly super-Poincare covariant formalism for the superstring has recently been constructed using a pure spinor variable. Unlike the covariant Green-Schwarz formalism, this new formalism is easily quantized with a BRST operator and tree-level scattering amplitudes have been evaluated in a manifestly covariant manner. In this paper, the cohomology of the BRST operator in the pure spinor formalism is shown to give the usual light-cone Green-Schwarz spectrum. Although the BRST operator does not directly involve the Virasoro constraint, this constraint emerges after expressing the pure spinor variable in terms of SO(8) variables. (author)

  19. Killing spinors as a characterisation of rotating black hole spacetimes

    International Nuclear Information System (INIS)

    Cole, Michael J; Kroon, Juan A Valiente

    2016-01-01

    We investigate the implications of the existence of Killing spinors in a spacetime. In particular, we show that in vacuum and electrovacuum a Killing spinor, along with some assumptions on the associated Killing vector in an asymptotic region, guarantees that the spacetime is locally isometric to the Kerr or Kerr–Newman solutions. We show that the characterisation of these spacetimes in terms of Killing spinors is an alternative expression of characterisation results of Mars (Kerr) and Wong (Kerr–Newman) involving restrictions on the Weyl curvature and matter content. (paper)

  20. Nonlinear Spinor Fields in Bianchi type-I spacetime reexamined

    OpenAIRE

    Saha, Bijan

    2013-01-01

    The specific behavior of spinor field in curve space-time with the exception of FRW model almost always gives rise to non-trivial non-diagonal components of the energy-momentum tensor. This non-triviality of non-diagonal components of the energy-momentum tensor imposes some severe restrictions either on the spinor field or on the metric functions. In this paper within the scope of an anisotropic Bianchi type-I Universe we study the role of spinor field in the evolution of the Universe. It is ...

  1. Chiral solitons in spinor polariton rings

    Science.gov (United States)

    Zezyulin, D. A.; Gulevich, D. R.; Skryabin, D. V.; Shelykh, I. A.

    2018-04-01

    We consider theoretically one-dimensional polariton ring accounting for both longitudinal-transverse (TE-TM) and Zeeman splittings of spinor polariton states and spin-dependent polariton-polariton interactions. We present a class of solutions in the form of the localized defects rotating with constant angular velocity and analyze their properties for realistic values of the parameters of the system. We show that the effects of the geometric phase arising from the interplay between the external magnetic field and the TE-TM splitting introduce chirality in the system and make solitons propagating in clockwise and anticlockwise directions nonequivalent. This can be interpreted as a solitonic analog of the Aharonov-Bohm effect.

  2. The b ghost of the pure spinor formalism is nilpotent

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo, E-mail: osvaldo.chandia@uai.c [Departamento de Ciencias, Facultad de Artes Liberales and Facultad de Ingenieria y Ciencias, Universidad Adolfo Ibanez, Santiago (Chile)

    2011-01-10

    The ghost for world-sheet reparametrization invariance is not a fundamental field in the pure spinor formalism. It is written as a combination of pure spinor variables which have conformal dimension two and such that it commutes with the BRST operator to give the world-sheet stress tensor. We show that the ghost variable defined in this way is nilpotent since the OPE of b with itself does not have singularities.

  3. Type I supergravity effective action from pure spinor formalism

    International Nuclear Information System (INIS)

    Alencar, Geova

    2009-01-01

    Using the pure spinor formalism, we compute the tree-level correlation functions for three strings, one closed and two open, in N = 1 D = 10 superspace. Expanding the superfields in components, the respective terms of the effective action for the type I supergravity are obtained. All terms found agree with the effective action known in the literature. This result gives one more consistency test for the pure spinor formalism.

  4. Spinor Field Nonlinearity and Space-Time Geometry

    Science.gov (United States)

    Saha, Bijan

    2018-03-01

    Within the scope of Bianchi type VI,VI0,V, III, I, LRSBI and FRW cosmological models we have studied the role of nonlinear spinor field on the evolution of the Universe and the spinor field itself. It was found that due to the presence of non-trivial non-diagonal components of the energy-momentum tensor of the spinor field in the anisotropic space-time, there occur some severe restrictions both on the metric functions and on the components of the spinor field. In this report we have considered a polynomial nonlinearity which is a function of invariants constructed from the bilinear spinor forms. It is found that in case of a Bianchi type-VI space-time, depending of the sign of self-coupling constants, the model allows either late time acceleration or oscillatory mode of evolution. In case of a Bianchi VI 0 type space-time due to the specific behavior of the spinor field we have two different scenarios. In one case the invariants constructed from bilinear spinor forms become trivial, thus giving rise to a massless and linear spinor field Lagrangian. This case is equivalent to the vacuum solution of the Bianchi VI 0 type space-time. The second case allows non-vanishing massive and nonlinear terms and depending on the sign of coupling constants gives rise to accelerating mode of expansion or the one that after obtaining some maximum value contracts and ends in big crunch, consequently generating space-time singularity. In case of a Bianchi type-V model there occur two possibilities. In one case we found that the metric functions are similar to each other. In this case the Universe expands with acceleration if the self-coupling constant is taken to be a positive one, whereas a negative coupling constant gives rise to a cyclic or periodic solution. In the second case the spinor mass and the spinor field nonlinearity vanish and the Universe expands linearly in time. In case of a Bianchi type-III model the space-time remains locally rotationally symmetric all the time

  5. Disordered spinor Bose-Hubbard model

    International Nuclear Information System (INIS)

    LaPcki, Mateusz; Paganelli, Simone; Ahufinger, Veronica; Sanpera, Anna; Zakrzewski, Jakub

    2011-01-01

    We study the zero-temperature phase diagram of the disordered spin-1 Bose-Hubbard model in a two-dimensional square lattice. To this aim, we use a mean-field Gutzwiller ansatz and a probabilistic mean-field perturbation theory. The spin interaction induces two different regimes, corresponding to a ferromagnetic and antiferromagnetic order. In the ferromagnetic case, the introduction of disorder reproduces analogous features of the disordered scalar Bose-Hubbard model, consisting in the formation of a Bose glass phase between Mott insulator lobes. In the antiferromagnetic regime, the phase diagram differs more from the scalar case. Disorder in the chemical potential can lead to the disappearance of Mott insulator lobes with an odd-integer filling factor and, for sufficiently strong spin coupling, to Bose glass of singlets between even-filling Mott insulator lobes. Disorder in the spinor coupling parameter results in the appearance of a Bose glass phase only between the n and the n+1 lobes for n odd. Disorder in the scalar Hubbard interaction inhibits Mott insulator regions for occupation larger than a critical value.

  6. Quantum entanglement as an aspect of pure spinor geometry

    International Nuclear Information System (INIS)

    Kiosses, V

    2014-01-01

    Relying on the mathematical analogy of the pure states of a two-qubit system with four-component Dirac spinors, we provide an alternative consideration of quantum entanglement using the mathematical formulation of Cartan's pure spinors. A result of our analysis is that the Cartan equation of a two-qubit state is entanglement sensitive in the same way that the Dirac equation for fermions is mass sensitive. The Cartan equation for unentangled qubits is reduced to a pair of Cartan equations for single qubits as the Dirac equation for massless fermions separates into two Weyl equations. Finally, we establish a correspondence between the separability condition in qubit geometry and the separability condition in spinor geometry. (paper)

  7. Pure spinor formalism as an N = 2 topological string

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2005-01-01

    Following suggestions of Nekrasov and Siegel, a non-minimal set of fields are added to the pure spinor formalism for the superstring. Twisted c-circumflex = 3 N = 2 generators are then constructed where the pure spinor BRST operator is the fermionic spin-one generator, and the formalism is interpreted as a critical topological string. Three applications of this topological string theory include the super-Poincare covariant computation of multiloop superstring amplitudes without picture-changing operators, the construction of a cubic open superstring field theory without contact-term problems, and a new four-dimensional version of the pure spinor formalism which computes F-terms in the spacetime action

  8. Spinor and isospinor structure of relativistic particle propagators

    International Nuclear Information System (INIS)

    Gitman, D.M.; Shvartsman, Sh.M.

    1993-07-01

    Representations by means of path integrals are used to find spinor and isospinor structure of relativistic particle propagators in external fields. For Dirac propagator in an external electromagnetic field all Grassmannian integrations are performed and a general result is presented via a bosonic path integral. The spinor structure of the integrand is given explicitly by its decomposition in the independent γ-matrix structures. A similar technique is used to get the isospinor structure of the scalar particle propagator in an external non-Abelian field. (author). 21 refs

  9. Pure spinors, free differential algebras, and the supermembrane

    International Nuclear Information System (INIS)

    Fre, Pietro; Grassi, Pietro Antonio

    2007-01-01

    The Lagrangian formalism for the supermembrane in any 11d supergravity background is constructed in the pure spinor framework. Our gauge-fixed action is manifestly BRST, supersymmetric, and 3d Lorentz invariant. The relation between the Free Differential Algebras (FDA) underlying 11d supergravity and the BRST symmetry of the membrane action is exploited. The 'gauge-fixing' has a natural interpretation as the variation of the Chevalley cohomology class needed for the extension of 11d super-Poincare superalgebra to M-theory FDA. We study the solution of the pure spinor constraints in full detail

  10. Pure spinors, free differential algebras, and the supermembrane

    Energy Technology Data Exchange (ETDEWEB)

    Fre, Pietro [Dipartimento di Fisica Teorica, Universita di Torino, and INFN-Sezione di Torino, Via P. Giuria 1, I-10125 Turin (Italy); Grassi, Pietro Antonio [Centro Studi e Ricerche E. Fermi, Compendio Viminale, I-00184 Rome (Italy) and DISTA, Universita del Piemonte Orientale, and INFN-Sezione di Torino, Via Bellini 25/G, Alessandria 15100 (Italy) and CERN, Theory Unit, CH-1211 Geneva 23 (Switzerland)]. E-mail: pgrassi@insti.physics.sunysb.edu

    2007-02-12

    The Lagrangian formalism for the supermembrane in any 11d supergravity background is constructed in the pure spinor framework. Our gauge-fixed action is manifestly BRST, supersymmetric, and 3d Lorentz invariant. The relation between the Free Differential Algebras (FDA) underlying 11d supergravity and the BRST symmetry of the membrane action is exploited. The 'gauge-fixing' has a natural interpretation as the variation of the Chevalley cohomology class needed for the extension of 11d super-Poincare superalgebra to M-theory FDA. We study the solution of the pure spinor constraints in full detail.

  11. Fourier transform and the Verlinde formula for the quantum double of a finite group

    NARCIS (Netherlands)

    Koornwinder, T.H.; Schroers, B.J.; Slingerland, J.K.; Bais, F.A.

    1999-01-01

    We define a Fourier transform $S$ for the quantum double $D(G)$ of a finite group $G$. Acting on characters of $D(G)$, $S$ and the central ribbon element of $D(G)$ generate a unitary matrix representation of the group $SL(2,Z)$. The characters form a ring over the integers under both the algebra

  12. Flag-dipole and flagpole spinor fluid flows in Kerr spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, Roldão da, E-mail: roldao.rocha@ufabc.edu.br [Universidade Federal do ABC, CMCC (Brazil); Cavalcanti, R. T., E-mail: rogerio.cavalcanti@ufabc.edu.br [Universidade Federal do ABC, CCNH (Brazil)

    2017-03-15

    Flagpole and flag-dipole spinors are particular classes of spinor fields that has been recently used in different branches of theoretical physics. In this paper, we study the possibility and consequences of these spinor fields to induce an underlying fluid flow structure in the background of Kerr spacetimes. We show that flag-dipole spinor fields are solutions of the equations of motion in this context. To our knowledge, this is the second time that this class of spinor field appears as a physical solution, the first one occurring as a solution of the Dirac equation in ESK gravities.

  13. Unveiling a spinor field classification with non-Abelian gauge symmetries

    Science.gov (United States)

    Fabbri, Luca; da Rocha, Roldão

    2018-05-01

    A spinor fields classification with non-Abelian gauge symmetries is introduced, generalizing the U(1) gauge symmetries-based Lounesto's classification. Here, a more general classification, contrary to the Lounesto's one, encompasses spinor multiplets, corresponding to non-Abelian gauge fields. The particular case of SU(2) gauge symmetry, encompassing electroweak and electromagnetic conserved charges, is then implemented by a non-Abelian spinor classification, now involving 14 mixed classes of spinor doublets. A richer flagpole, dipole, and flag-dipole structure naturally descends from this general classification. The Lounesto's classification of spinors is shown to arise as a Pauli's singlet, into this more general classification.

  14. IIB solutions with N>28 Killing spinors are maximally supersymmetric

    International Nuclear Information System (INIS)

    Gran, U.; Gutowski, J.; Papadopoulos, G.; Roest, D.

    2007-01-01

    We show that all IIB supergravity backgrounds which admit more than 28 Killing spinors are maximally supersymmetric. In particular, we find that for all N>28 backgrounds the supercovariant curvature vanishes, and that the quotients of maximally supersymmetric backgrounds either preserve all 32 or N<29 supersymmetries

  15. Complex vector triads in spinor theory in Minkowski space

    International Nuclear Information System (INIS)

    Zhelnorovich, V.A.

    1990-01-01

    It is shown that tensor equations corresponding to the spinor Dirac equations represent a three-dimensional part of four-dimensional vector equations. The equations are formulated in an evidently invariant form in antisymmetric tensor components and in the corresponding components of a complex vector triad. A complete system of relativistically invariant tensor equations is ascertained

  16. Discrete symmetries for spinor field in de Sitter space

    International Nuclear Information System (INIS)

    Moradi, S.; Rouhani, S.; Takook, M.V.

    2005-01-01

    Discrete symmetries, parity, time reversal, antipodal, and charge conjugation transformations for spinor field in de Sitter space, are presented in the ambient space notation, i.e., in a coordinate independent way. The PT and PCT transformations are also discussed in this notation. The five-current density is studied and their transformation under the discrete symmetries is discussed

  17. Ambitwistor pure spinor string in a type II supergravity background

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); Vallilo, Brenno Carlini [Departamento de Ciencias Físicas, Facultad de Ciencias Exactas, Universidad Andres Bello,República 220, Santiago (Chile)

    2015-06-30

    We construct the ambitwistor pure spinor string in a general type II supergravity background in the semi-classical regime. Almost all supergravity constraints are obtained from nilpotency of the BRST charge and further consistency conditions from additional world-sheet the case of AdS{sub 5}×S{sup 5} background.

  18. Spontaneous symmetry breaking in spinor Bose-Einstein condensates

    DEFF Research Database (Denmark)

    Scherer, Manuel; Lücke, Bernd; Peise, Jan

    2013-01-01

    We present an analytical model for the theoretical analysis of spin dynamics and spontaneous symmetry breaking in a spinor Bose-Einstein condensate (BEC). This allows for an excellent intuitive understanding of the processes and provides good quantitative agreement with the experimental results...

  19. A double standard when group members behave badly: transgression credit to ingroup leaders.

    Science.gov (United States)

    Abrams, Dominic; Randsley de Moura, Georgina; Travaglino, Giovanni A

    2013-11-01

    This research tested the hypothesis that people forgive serious transgressions by ingroup leaders but not by other group members or outgroup leaders. They apply a double standard in judgments of ingroup leaders. A series of studies (N = 623), using an array of different ingroups and outgroups, tested how group members judged ingroup or outgroup leaders and nonleaders who unexpectedly transgressed or did not transgress in important intergroup scenarios. Experiments 1, 2, and 4 focused on captains and players in either soccer or netball sports competitions. Across studies, transgressive captains of ingroup teams were evaluated more favorably than captains from outgroup teams and (Experiments 1, 2, and 4) more favorably than transgressive ingroup players. Experiment 3 demonstrated the double standard in a minimal group paradigm. Experiment 5 showed that the double standard is only applied if the leader is perceived as serving the group's interest. Across studies, the double standard is evident in evaluations toward, inclusion and punishment of, and rewards to the transgressive targets. Implications for sport, politics, and business and intergroup conflict are discussed. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  20. Spinor bose gases in cubic optical lattice

    International Nuclear Information System (INIS)

    Mobarak, Mohamed Saidan Sayed Mohamed

    2014-01-01

    In recent years the quantum simulation of condensed-matter physics problems has resulted from exciting experimental progress in the realm of ultracold atoms and molecules in optical lattices. In this thesis we analyze theoretically a spinor Bose gas loaded into a three-dimensional cubic optical lattice. In order to account for different superfluid phases of spin-1 bosons with a linear Zeeman effect, we work out a Ginzburg-Landau theory for the underlying spin-1 Bose-Hubbard model. To this end we add artificial symmetry-breaking currents to the spin-1 Bose-Hubbard Hamiltonian in order to break the global U (1) symmetry. With this we determine a diagrammatic expansion of the grand-canonical free energy up to fourth order in the symmetry-breaking currents and up to the leading non-trivial order in the hopping strength which is of first order. As a cross-check we demonstrate that the resulting grand-canonical free energy allows to recover the mean-field theory. Applying a Legendre transformation to the grand-canonical free energy, where the symmetry-breaking currents are transformed to order parameters, we obtain the effective Ginzburg-Landau action. With this we calculate in detail at zero temperature the Mott insulator-superfluid quantum phase boundary as well as condensate and particle number density in the superfluid phase. We find that both mean-field and Ginzburg-Landau theory yield the same quantum phase transition between the Mott insulator and superfluid phases, but the range of validity of the mean-field theory turns out to be smaller than that of the Ginzburg-Landau theory. Due to this finding we expect that the Ginzburg-Landau theory gives better results for the superfluid phase and, thus, we restrict ourselves to extremize only the effective Ginzburg-Landau action with respect to the order parameters. Without external magnetic field the superfluid phase is a polar (ferromagnetic) state for anti-ferromagnetic (ferromagnetic) interactions, i.e. only the

  1. Opening the Pandora's box of quantum spinor fields

    Energy Technology Data Exchange (ETDEWEB)

    Bonora, L. [International School for Advanced Studies-SISSA, Trieste (Italy); Silva, J.M.H. da [Universidade Estadual Paulista-UNESP, Departamento de Fisica e Quimica, Guaratingueta, SP (Brazil); Rocha, R. da [Universidade Federal do ABC-UFABC, Centro de Matematica, Computacao e Cognicao, Santo Andre (Brazil)

    2018-02-15

    Lounesto's classification of spinors is a comprehensive and exhaustive algorithm that, based on the bilinears covariants, discloses the possibility of a large variety of spinors, comprising regular and singular spinors and their unexpected applications in physics and including the cases of Dirac, Weyl, and Majorana as very particular spinor fields. In this paper we pose the problem of an analogous classification in the framework of second quantization. We first discuss in general the nature of the problem. Then we start the analysis of two basic bilinear covariants, the scalar and pseudoscalar, in the second quantized setup, with expressions applicable to the quantum field theory extended to all types of spinors. One can see that an ampler set of possibilities opens up with respect to the classical case. A quantum reconstruction algorithm is also proposed. The Feynman propagator is extended for spinors in all classes. (orig.)

  2. Harmonic spinors on a family of Einstein manifolds

    Science.gov (United States)

    Franchetti, Guido

    2018-06-01

    The purpose of this paper is to study harmonic spinors defined on a 1-parameter family of Einstein manifolds which includes Taub–NUT, Eguchi–Hanson and with the Fubini–Study metric as particular cases. We discuss the existence of and explicitly solve for spinors harmonic with respect to the Dirac operator twisted by a geometrically preferred connection. The metrics examined are defined, for generic values of the parameter, on a non-compact manifold with the topology of and extend to as edge-cone metrics. As a consequence, the subtle boundary conditions of the Atiyah–Patodi–Singer index theorem need to be carefully considered in order to show agreement between the index of the twisted Dirac operator and the result obtained by counting the explicit solutions.

  3. Double-Group Particle Swarm Optimization and Its Application in Remote Sensing Image Segmentation.

    Science.gov (United States)

    Shen, Liang; Huang, Xiaotao; Fan, Chongyi

    2018-05-01

    Particle Swarm Optimization (PSO) is a well-known meta-heuristic. It has been widely used in both research and engineering fields. However, the original PSO generally suffers from premature convergence, especially in multimodal problems. In this paper, we propose a double-group PSO (DG-PSO) algorithm to improve the performance. DG-PSO uses a double-group based evolution framework. The individuals are divided into two groups: an advantaged group and a disadvantaged group. The advantaged group works according to the original PSO, while two new strategies are developed for the disadvantaged group. The proposed algorithm is firstly evaluated by comparing it with the other five popular PSO variants and two state-of-the-art meta-heuristics on various benchmark functions. The results demonstrate that DG-PSO shows a remarkable performance in terms of accuracy and stability. Then, we apply DG-PSO to multilevel thresholding for remote sensing image segmentation. The results show that the proposed algorithm outperforms five other popular algorithms in meta-heuristic-based multilevel thresholding, which verifies the effectiveness of the proposed algorithm.

  4. Scattering of massive open strings in pure spinor

    International Nuclear Information System (INIS)

    Park, I.Y.

    2011-01-01

    In Park (2008) , it was proposed that the D-brane geometry could be produced by open string quantum effects. In an effort to verify the proposal, we consider scattering amplitudes involving massive open superstrings. The main goal of this paper is to set the ground for two-loop 'renormalization' of an oriented open superstring on a D-brane and to strengthen our skill in the pure spinor formulation of a superstring, an effective tool for multi-loop string diagrams. We start by reviewing scattering amplitudes of massless states in the 2D component method of the NSR formulation. A few examples of massive string scattering are worked out. The NSR results are then reproduced in the pure spinor formulation. We compute the amplitudes using the unintegrated form of the massive vertex operator constructed by Berkovits and Chandia (2002) . We point out that it may be possible to discover new Riemann type identities involving Jacobi θ-functions by comparing a NSR computation and the corresponding pure spinor computation.

  5. Baryonic sources using irreducible representations of the double-covered octahedral group

    International Nuclear Information System (INIS)

    Basak, S.; Edwards, R.; Fiebig, R.; Fleming, G.T.; Heller, U.M.; Morningstar, C.; Richards, D.; Sato, I.; Wallace, S.

    2005-01-01

    Irreducible representations (IRs) of the double-covered octahedral group are used to construct lattice source and sink operators for three-quark baryons. The goal is to achieve a good coupling to higher spin states as well as ground states. Complete sets of local and nonlocal straight-link operators are explicitly shown for isospin 1/2 and 3/2 baryons. The orthogonality relations of the IR operators are confirmed in a quenched lattice simulation

  6. Baryonic sources using irreducible representations of the double-covered octahedral group

    International Nuclear Information System (INIS)

    Basak, S.; Edwards, R.; Fiebig, R.; Fleming, G. T.; Heller, U. M.; Morningstar, C.; Richards, D.; Sato, I.; Wallace, S.

    2004-01-01

    Irreducible representations (IRs) of the double-covered octahedral group are used to construct lattice source and sink operators for three-quark baryons. The goal is to achieve a good coupling to higher spin states as well as ground states. Complete sets of local and nonlocal straight-link operators are explicitly shown for isospin 1/2 and 3/2 baryons. The orthogonality relations of the IR operators are confirmed in a quenched lattice simulation

  7. From pure spinors to quantum physics and to some classical field equations like Maxwell's and gravitational

    International Nuclear Information System (INIS)

    Budinich, Paolo

    2009-03-01

    In a previous paper we proposed a purely mathematical way to quantum mechanics based on Cartan's simple spinors in their most elementary form of 2 components spinors. Here we proceed along that path proposing, this time, a symmetric tensor, quadrilinear in simple spinors, as a candidate for the symmetric tensor of general relativity. The procedure resembles closely that in which one builds bilinearly from simple spinors an asymmetric electromagnetic tensor, from which easily descend Maxwell's equations and the photon can be seen as a bilinear combination of neutrinos. Here Lorentzian spaces result compact, building up spheres, where hopefully the problems of the Standard Model could be solved. (author)

  8. The bundles of algebraic and Dirac-Hestenes spinor fields

    International Nuclear Information System (INIS)

    Mosna, Ricardo A.; Rodrigues, Waldyr A. Jr.

    2004-01-01

    Our main objective in this paper is to clarify the ontology of Dirac-Hestenes spinor fields (DHSF) and its relationship with even multivector fields, on a Riemann-Cartan spacetime (RCST) M=(M,g,∇,τ g ,↑) admitting a spin structure, and to give a mathematically rigorous derivation of the so-called Dirac-Hestenes equation (DHE) in the case where M is a Lorentzian spacetime (the general case when M is a RCST will be discussed in another publication). To this aim we introduce the Clifford bundle of multivector fields (Cl(M,g)) and the left (Cl Spin 1,3 e l (M)) and right (Cl Spin 1,3 e r (M)) spin-Clifford bundles on the spin manifold (M,g). The relation between left ideal algebraic spinor fields (LIASF) and Dirac-Hestenes spinor fields (both fields are sections of Cl Spin 1,3 e l (M)) is clarified. We study in detail the theory of covariant derivatives of Clifford fields as well as that of left and right spin-Clifford fields. A consistent Dirac equation for a DHSF Ψ is a member of sec Cl Spin 1,3 e l (M) (denoted DECl l ) on a Lorentzian spacetime is found. We also obtain a representation of the DECl l in the Clifford bundle Cl(M,g). It is such equation that we call the DHE and it is satisfied by Clifford fields ψ Ξ is a member of sec Cl(M,g). This means that to each DHSF Ψ is a member of sec Cl Spin 1,3 e l (M) and spin frame Ξ is a member of sec P Spin 1,3 e (M), there is a well-defined sum of even multivector fields ψ Ξ isa member of sec Cl(M,g) (EMFS) associated with Ψ. Such an EMFS is called a representative of the DHSF on the given spin frame. And, of course, such a EMFS (the representative of the DHSF) is not a spinor field. With this crucial distinction between a DHSF and its representatives on the Clifford bundle, we provide a consistent theory for the covariant derivatives of Clifford and spinor fields of all kinds. We emphasize that the DECl l and the DHE, although related, are equations of different mathematical natures. We study also the

  9. Two-spinor description of massive particles and relativistic spin projection operators

    Directory of Open Access Journals (Sweden)

    A.P. Isaev

    2018-04-01

    Full Text Available On the basis of the Wigner unitary representations of the covering group ISL(2,C of the Poincaré group, we obtain spin-tensor wave functions of free massive particles with arbitrary spin. The wave functions automatically satisfy the Dirac–Pauli–Fierz equations. In the framework of the two-spinor formalism we construct spin-vectors of polarizations and obtain conditions that fix the corresponding relativistic spin projection operators (Behrends–Fronsdal projection operators. With the help of these conditions we find explicit expressions for relativistic spin projection operators for integer spins (Behrends–Fronsdal projection operators and then find relativistic spin projection operators for half integer spins. These projection operators determine the numerators in the propagators of fields of relativistic particles. We deduce generalizations of the Behrends–Fronsdal projection operators for arbitrary space–time dimensions D>2.

  10. Two-spinor description of massive particles and relativistic spin projection operators

    Science.gov (United States)

    Isaev, A. P.; Podoinitsyn, M. A.

    2018-04-01

    On the basis of the Wigner unitary representations of the covering group ISL (2 , C) of the Poincaré group, we obtain spin-tensor wave functions of free massive particles with arbitrary spin. The wave functions automatically satisfy the Dirac-Pauli-Fierz equations. In the framework of the two-spinor formalism we construct spin-vectors of polarizations and obtain conditions that fix the corresponding relativistic spin projection operators (Behrends-Fronsdal projection operators). With the help of these conditions we find explicit expressions for relativistic spin projection operators for integer spins (Behrends-Fronsdal projection operators) and then find relativistic spin projection operators for half integer spins. These projection operators determine the numerators in the propagators of fields of relativistic particles. We deduce generalizations of the Behrends-Fronsdal projection operators for arbitrary space-time dimensions D > 2.

  11. Infinite dwell time and group delay in resonant electron tunneling through double complex potential barrier

    Science.gov (United States)

    Opacak, Nikola; Milanović, Vitomir; Radovanović, Jelena

    2017-12-01

    Tunneling times in complex potentials are investigated. Analytical expressions for dwell time, self-interference time and group delay are obtained for the case of complex double delta potentials. It is shown that we can always find a set of parameters of the potential so that the tunneling times achieve very large values and even approach infinity for the case of resonance. The phenomenon of infinite tunneling times occurs for only one particular positive value of the imaginary part of the potential, if all other parameters are given.

  12. Spinor Field Realizations of Non-critical $W_{2,s}$ Strings

    OpenAIRE

    Duan, Yi-Shi; Liu, Yu-Xiao; Zhang, Li-Jie

    2005-01-01

    In this paper, we construct the nilpotent Becchi-Rouet-Stora-Tyutin($BRST$) charges of spinor non-critical $W_{2,s}$ strings. The cases of $s=3,4$ are discussed in detail, and spinor realization for $s=4$ is given explicitly. The $BRST$ charges are graded.

  13. Spinor field realizations of non-critical W2,s strings

    International Nuclear Information System (INIS)

    Duan, Y.S.; Liu, Y.X.; Zhang, L.J.

    2004-01-01

    In this paper, we construct the nilpotent Becchi-Rouet-Stora-Tyutin (BRST) charges of spinor non-critical W2,s strings. The cases of s=3,4 are discussed in detail, and spinor realization for s=4 is given explicitly. The BRST charges are graded

  14. Minimal surfaces and strings from spinors a realization of the Cartan programme

    International Nuclear Information System (INIS)

    Budinich, P.; Dabrowski, L.; Furlan, P.

    1986-01-01

    It is shown how the old Enneper-Weierstrass integral parametrization of minimal surfaces in R 3 and the Eisenhart ones in Rsup(3,1), when expressed through bilinear spinor polynomia, may be considered as deriving from a particular local realization of the possibility envisaged by Cartan: to consider ordinary vectors as generated from isotropic planes in complex spaces, in the frame of the bijective Cartan map connecting pure spinor directions to totally null planes in complex spaces. In the case of R 3 the corresponding global realization of the Cartan map extends the Enneper-Weierstrass parametrization to the Gauss-conformal map of the minimal surface to S 2 , which may be identified with the Riemann celestial sphere. For real spinors minimal surfaces are substituted by strings both in Rsup(2,1) and Rsup(3,1); in Rsup(2,1) strings are globally mapped to a torus(in R 4 ). In Rsup(3,1) (and its conformal extensions) a prescription is given to obtain strings as integrals of real, bilinear spinor null vectors, from the Enneper-Weierstrass spinor representation of minimal surfaces, through the use of unitary transformations in spinor space which allows its restriction to the real (Majorana spinor-space). It is shown that the Nambu action, or the area of the world surface described by the space-time string, is minimized by the Lagrangian density expressed as a quadrilinear spinor product formally reminding Fermi and Thirring interaction Lagrangians

  15. Infinite tension limit of the pure spinor superstring

    Energy Technology Data Exchange (ETDEWEB)

    Berkovits, Nathan [ICTP South American Institute for Fundamental Research,Instituto de Física Teórica, UNESP - Univ. Estadual Paulista,Rua Dr. Bento T. Ferraz 271, 01140-070, São Paulo, SP (Brazil)

    2014-03-04

    Mason and Skinner recently constructed a chiral infinite tension limit of the Ramond-Neveu-Schwarz superstring which was shown to compute the Cachazo-He-Yuan formulae for tree-level d=10 Yang-Mills amplitudes and the NS-NS sector of tree-level d=10 supergravity amplitudes. In this letter, their chiral infinite tension limit is generalized to the pure spinor superstring which computes a d=10 superspace version of the Cachazo-He-Yuan formulae for tree-level d=10 super-Yang-Mills and supergravity amplitudes.

  16. Maximal entanglement of two spinor Bose-Einstein condensates

    OpenAIRE

    Jack, Michael W.; Yamashita, Makoto

    2005-01-01

    Starting with two weakly-coupled anti-ferromagnetic spinor condensates, we show that by changing the sign of the coefficient of the spin interaction, $U_{2}$, via an optically-induced Feshbach resonance one can create an entangled state consisting of two anti-correlated ferromagnetic condensates. This state is maximally entangled and a generalization of the Bell state from two anti-correlated spin-1/2 particles to two anti-correlated spin$-N/2$ atomic samples, where $N$ is the total number of...

  17. Relativistic algebraic spinors and quantum motions in phase space

    International Nuclear Information System (INIS)

    Holland, P.R.

    1986-01-01

    Following suggestions of Schonberg and Bohm, we study the tensorial phase space representation of the Dirac and Feynman-Gell-Mann equations in terms of the complex Dirac algebra C 4 , a Jordan-Wigner algebra G 4 , and Wigner transformations. To do this we solve the problem of the conditions under which elements in C 4 generate minimal ideals, and extend this to G 4 . This yields the linear theory of Dirac spin spaces and tensor representations of Dirac spinors, and the spin-1/2 wave equations are represented through fermionic state vectors in a higher space as a set of interconnected tensor relations

  18. Spinors in euclidean field theory, complex structures and discrete symmetries

    International Nuclear Information System (INIS)

    Wetterich, C.

    2011-01-01

    We discuss fermions for arbitrary dimensions and signature of the metric, with special emphasis on euclidean space. Generalized Majorana spinors are defined for d=2,3,4,8,9mod8, independently of the signature. These objects permit a consistent analytic continuation of Majorana spinors in Minkowski space to euclidean signature. Compatibility of charge conjugation with complex conjugation requires for euclidean signature a new complex structure which involves a reflection in euclidean time. The possible complex structures for Minkowski and euclidean signature can be understood in terms of a modulo two periodicity in the signature. The concepts of a real action and hermitean observables depend on the choice of the complex structure. For a real action the expectation values of all hermitean multi-fermion observables are real. This holds for arbitrary signature, including euclidean space. In particular, a chemical potential is compatible with a real action for the euclidean theory. We also discuss the discrete symmetries of parity, time reversal and charge conjugation for arbitrary dimension and signature.

  19. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes

    NARCIS (Netherlands)

    Kerkhoffs, G. M. M. J.; Struijs, P. A. A.; de Wit, C.; Rahlfs, V. W.; Zwipp, H.; van Dijk, C. N.

    2004-01-01

    Objective: To compare the effectiveness and safety of the triple combination Phlogenzym ( rutoside, bromelain, and trypsin) with double combinations, the single substances, and placebo. Design: Multinational, multicentre, double blind, randomised, parallel group design with eight groups structured

  20. Classical local SU(3 gauge invariance in Weyl 2-spinor language and quark–gluon plasma equations of motion

    Directory of Open Access Journals (Sweden)

    J. Buitrago

    Full Text Available In a new classical Weyl 2-spinor approach to non abelian gauge theories, starting with the U(1 gauge group in a previous work, we study now the SU(3 case corresponding to quarks (antiquarks interacting with color fields. The principal difference with the conventional approach is that particle-field interactions are not described by means of potentials but by the field strength magnitudes. Some analytical expressions showing similarities with electrodynamics are obtained. Classical equations that describe the behavior of quarks under gluon fields might be in principle applied to the quark–gluon plasma phase existing during the first instants of the Universe.

  1. Null structure groups in eleven dimensions

    International Nuclear Information System (INIS)

    Cariglia, Marco; Mac Conamhna, Oisin A. P.

    2006-01-01

    We classify all the structure groups which arise as subgroups of the isotropy group (Spin(7)xR 8 )xR, of a single null Killing spinor in 11 dimensions. We construct the spaces of spinors fixed by these groups. We determine the conditions under which structure subgroups of the maximal null structure group (Spin(7)xR 8 )xR may also be embedded in SU(5), and hence the conditions under which a supersymmetric spacetime admits only null, or both timelike and null, Killing spinors. We discuss how this purely algebraic material will facilitate the direct analysis of the Killing spinor equation of 11 dimensional supergravity, and the classification of supersymmetric spacetimes therein

  2. Covariant map between Ramond-Neveu-Schwarz and pure spinor formalisms for the superstring

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2014-01-01

    A covariant map between the Ramond-Neveu-Schwarz (RNS) and pure spinor formalisms for the superstring is found which transforms the RNS and pure spinor BRST operators into each other. The key ingredient is a dynamical twisting of the ten spin-half RNS fermions into five spin-one and five spin-zero fermions using bosonic pure spinors that parameterize an SO(10)/U(5) coset. The map relates massless vertex operators in the two formalisms, and gives a new description of Ramond states which does not require spin fields. An argument is proposed for relating the amplitude prescriptions in the two formalisms

  3. q-deformed conformal and Poincare algebras on quantum 4-spinors

    International Nuclear Information System (INIS)

    Kobayashi, Tatsuo; Uematsu, Tsuneo

    1993-01-01

    We investigate quantum deformation of conformal algebras by constructing the quantum space for sl q (4). The differential calculus on the quantum space and the action of the quantum generators are studied. We derive deformed su(2, 2) algebra from the deformed sl(4) algebra using the quantum 4-spinor and its conjugate spinor. The quantum 6-vector in so q (4, 2) is constructed as a tensor product of two sets of 4-spinors. We obtain the q-deformed conformal algebra with the suitable assignment of the generators which satisfy the reality condition. The deformed Poincare algebra is derived through a contraction procedure. (orig.)

  4. Optical propagators in vector and spinor theories by path integral formalism

    International Nuclear Information System (INIS)

    Linares, J.

    1993-01-01

    The construction of an extended parabolic (wide-angle) vector and spinor wave theory is presented. For that, optical propagators in monochromatic vector light optics and monoenergetic spinor electron optics are evaluated by the path integral formalism. The auxiliary parameter method introduced by Fock and the Feynman-Dyson perturbative series are used. The proposed theory supplies, by a generalized Fermat's principle, the Mukunda-Simon-Sudarshan transformation for the passage from scalar to vector light (or spinor electron) optics in an asymptotic approximation. (author). 19 refs

  5. Spinor monopole harmonics and the Pauli spin equation

    International Nuclear Information System (INIS)

    Pereira, J.G.; Ferreira, P.L.

    1982-01-01

    In the framework of Wu and Yang theory of U(1) magnetic monopoles, two problems are revisited: (i) the binding of spin-0 monopole to a spin-1/2 particle possessing an arbitrary magnetic dipole moment, and (ii) the energy levels and properties of the electron-dyon system. In both problems, the spin-1/2 particle is assumed to obey the Pauli spin equation. Spin-orbit and other higher order terms are treated as a perturbation, in connection with the second mentioned problem. Wu and Yang's spinor monopole harmonics allow an elegant and simplified treatment of those problems. The results obtained are in good agreement with those obtained in older papers. (Author) [pt

  6. Spinors fields in co-dimension one braneworlds

    Science.gov (United States)

    Mendes, W. M.; Alencar, G.; Landim, R. R.

    2018-02-01

    In this work we analyze the zero mode localization and resonances of 1/2-spin fermions in co-dimension one Randall-Sundrum braneworld scenarios. We consider delta-like, domain walls and deformed domain walls membranes. Beyond the influence of the spacetime dimension D we also consider three types of couplings: (i) the standard Yukawa coupling with the scalar field and parameter η 1, (ii) a Yukawa-dilaton coupling with two parameters η 2 and λ and (iii) a dilaton derivative coupling with parameter h. Together with the deformation parameter s, we end up with five free parameter to be considered. For the zero mode we find that the localization is dependent of D, because the spinorial representation changes when the bulk dimensionality is odd or even and must be treated separately. For case (i) we find that in odd dimensions only one chirality can be localized and for even dimension a massless Dirac spinor is trapped over the brane. In the cases (ii) and (iii) we find that for some values of the parameters, both chiralities can be localized in odd dimensions and for even dimensions we obtain that the massless Dirac spinor is trapped over the brane. We also calculated numerically resonances for cases (ii) and (iii) by using the transfer matrix method. We find that, for deformed defects, the increasing of D induces a shift in the peaks of resonances. For a given λ with domain walls, we find that the resonances can show up by changing the spacetime dimensionality. For example, the same case in D = 5 do not induces resonances but when we consider D = 10 one peak of resonance is found. Therefore the introduction of more dimensions, diversely from the bosonic case, can change drastically the zero mode and resonances in fermion fields.

  7. Quantum theory of spinor field in four-dimensional Riemannian space-time

    International Nuclear Information System (INIS)

    Shavokhina, N.S.

    1996-01-01

    The review deals with the spinor field in the four-dimensional Riemannian space-time. The field beys the Dirac-Fock-Ivanenko equation. Principles of quantization of the spinor field in the Riemannian space-time are formulated which in a particular case of the plane space-time are equivalent to the canonical rules of quantization. The formulated principles are exemplified by the De Sitter space-time. The study of quantum field theory in the De Sitter space-time is interesting because it itself leads to a method of an invariant well for plane space-time. However, the study of the quantum spinor field theory in an arbitrary Riemannian space-time allows one to take into account the influence of the external gravitational field on the quantized spinor field. 60 refs

  8. Spinor-electron wave guided modes in coupled quantum wells structures by solving the Dirac equation

    International Nuclear Information System (INIS)

    Linares, Jesus; Nistal, Maria C.

    2009-01-01

    A quantum analysis based on the Dirac equation of the propagation of spinor-electron waves in coupled quantum wells, or equivalently coupled electron waveguides, is presented. The complete optical wave equations for Spin-Up (SU) and Spin-Down (SD) spinor-electron waves in these electron guides couplers are derived from the Dirac equation. The relativistic amplitudes and dispersion equations of the spinor-electron wave-guided modes in a planar quantum coupler formed by two coupled quantum wells, or equivalently by two coupled slab electron waveguides, are exactly derived. The main outcomes related to the spinor modal structure, such as the breaking of the non-relativistic degenerate spin states, the appearance of phase shifts associated with the spin polarization and so on, are shown.

  9. Non-minimal fields of the pure spinor string in general curved backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); Vallilo, Brenno Carlini [Departamento de Ciencias Físicas, Facultad de Ciencias Exactas, Universidad Andrés Bello,República 220, Santiago (Chile)

    2015-02-16

    We study the coupling of the non-minimal ghost fields of the pure spinor superstring in general curved backgrounds. The coupling is found solving the consistency relations from the nilpotency of the non-minimal BRST charge.

  10. Existence of parallel spinors on non-simply-connected Riemannian manifolds

    International Nuclear Information System (INIS)

    McInnes, B.

    1997-04-01

    It is well known, and important for applications, that Ricci-flat Riemannian manifolds of non-generic holonomy always admit a parallel [covariant constant] spinor if they are simply connected. The non-simply-connected case is much more subtle, however. We show that a parallel spinor can still be found in this case provided that the [real] dimension is not a multiple of four, and provided that the spin structure is carefully chosen. (author). 10 refs

  11. Dirac operators and Killing spinors with torsion; Dirac-Operatoren und Killing-Spinoren mit Torsion

    Energy Technology Data Exchange (ETDEWEB)

    Becker-Bender, Julia

    2012-12-17

    On a Riemannian spin manifold with parallel skew torsion, we use the twistor operator to obtain an eigenvalue estimate for the Dirac operator with torsion. We consider the equality case in dimensions four and six. In odd dimensions we describe Sasaki manifolds on which equality in the estimate is realized by Killing spinors with torsion. In dimension five we characterize all Killing spinors with torsion and obtain certain naturally reductive spaces as exceptional cases.

  12. A compact expression for bilinear combination of Dirac spinors via world tensors

    International Nuclear Information System (INIS)

    Rogalev, R.N.

    1994-01-01

    A compact expression for a product of two Dirac spinors is obtained as a linear combination of 16 Dirac γ-matrices. The result is presented in a convenient from, which can give rise to using it for analytical calculations of multiparticle amplitudes. It has been shown that a bilinear combination of Dirac spinors can be expressed by momentum and spin vectors of the corresponding particles up to a phase factor. 8 refs

  13. Relation of a unified quantum field theory of spinors to the structure of general relativity

    International Nuclear Information System (INIS)

    Kober, Martin

    2009-01-01

    Based on a unified quantum field theory of spinors assumed to describe all matter fields and their interactions we construct the space-time structure of general relativity according to a general connection within the corresponding spinor space. The tetrad field and the corresponding metric field are composed from a space-time dependent basis of spinors within the internal space of the fundamental matter field. Similar to twistor theory the Minkowski signature of the space-time metric is related to this spinor nature of elementary matter, if we assume the spinor space to be endowed with a symplectic structure. The equivalence principle and the property of background independence arise from the fact that all elementary fields are composed from the fundamental spinor field. This means that the structure of space-time according to general relativity seems to be a consequence of a fundamental theory of matter fields and not a presupposition as in the usual setting of relativistic quantum field theories.

  14. Phosphor Dysprosium-Doped Layered Double Hydroxides Exchanged with Different Organic Functional Groups

    Directory of Open Access Journals (Sweden)

    David Ricardo Martínez Vargas

    2013-01-01

    Full Text Available The layers of a Zn/Al layered double hydroxide (LDH were doped with Dy3+ cations. Among some compositions, the Zn2+ : Al3+ : Dy3+ molar ratio equal to 30 : 9 : 1 presented a single crystalline phase. Organic anions with carboxylic, amino, sulfate, or phosphate functional groups were intercalated as single layers between LDH layers as confirmed by X-ray diffraction and infrared spectroscopy. Photoluminescence spectra of the nitrate intercalated LDH showed a wide emission band with strong intensity in the yellow region (around 574 nm, originated due to symmetry distortion of the octahedral coordination in dysprosium centers. Moreover, a broad red band emission was also detected apparently due to the presence of zinc oxide. The distorted symmetry of the dysprosium coordination environment, also confirmed by X-ray photoelectron spectroscopy analysis, was modified after the intercalation with phenyl phosphonate (PP, aspartate (Asp, adipate (Adip, and serinate (Ser anions; the emission as measured from PL spectra of these LDH was more intense in the blue region (ca. 486 nm, thus indicating an increase in symmetry of dysprosium octahedrons. The red emission band from zinc oxide kept the same intensity after intercalation of dodecyl sulfate (DDS. An additional emission of unknown origin at λ = 767 nm was present in all LDHs.

  15. de Sitter symmetry of Neveu-Schwarz spinors

    International Nuclear Information System (INIS)

    Epstein, Henri; Moschella, Ugo

    2016-01-01

    We study the relations between Dirac fields living on the 2-dimensional Lorentzian cylinder and the ones living on the double-covering of the 2-dimensional de Sitter manifold, here identified as a certain coset space of the group SL(2,R). We show that there is an extended notion of de Sitter covariance only for Dirac fields having the Neveu-Schwarz anti-periodicity and construct the relevant cocycle. Finally, we show that the de Sitter symmetry is naturally inherited by the Neveu-Schwarz massless Dirac field on the cylinder.

  16. Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups.

    Science.gov (United States)

    Micali, E; Chehade, K A; Isaacs, R J; Andres, D A; Spielmann, H P

    2001-10-16

    Farnesylation is a posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins in a reaction catalyzed by protein farnesyltransferase (FTase). We synthesized the benzyloxyisoprenyl pyrophosphate (BnPP) series of transferable farnesyl pyrophosphate (FPP) analogues (1a-e) to test the length dependence of the isoprenoid substrate on the FTase-catalyzed transfer of lipid to protein substrate. Kinetic analyses show that pyrophosphates 1a-e and geranyl pyrophosphate (GPP) transfer with a lower efficiency than FPP whereas geranylgeranyl pyrophosphate (GGPP) does not transfer at all. While a correlation was found between K(m) and analogue hydrophobicity and length, there was no correlation between k(cat) and these properties. Potential binding geometries of FPP, GPP, GGPP, and analogues 1a-e were examined by modeling the molecules into the active site of the FTase crystal structure. We found that analogue 1d displaces approximately the same volume of the active site as does FPP, whereas GPP and analogues 1a-c occupy lesser volumes and 1e occupies a slightly larger volume. Modeling also indicated that GGPP adopts a different conformation than the farnesyl chain of FPP, partially occluding the space occupied by the Ca(1)a(2)X peptide in the ternary X-ray crystal structure. Within the confines of the FTase pocket, the double bonds and branched methyl groups of the geranylgeranyl chain significantly restrict the number of possible conformations relative to the more flexible lipid chain of analogues 1a-e. The modeling results also provide a molecular explanation for the observation that an aromatic ring is a good isostere for the terminal isoprene of FPP.

  17. Random walks and a simple chirally invariant lattice Hamiltonian without fermion doubling

    International Nuclear Information System (INIS)

    Belyea, C.I.

    1992-01-01

    It is shown that there is a simple chirally-invariant lattice Hamiltonian for fermions which is doubling-free but non-Hermitian and which may be valuable in lattice Hamiltonian studies of quantum chromodynamics. A connection is established between the existence of random walk representations of spinor propagators and this doubling-free formulation, in analogy with Wilson fermions. 15 refs

  18. Do spinors give rise to a frame-dragging effect?

    International Nuclear Information System (INIS)

    Randono, Andrew

    2010-01-01

    We investigate the effect of the intrinsic spin of a fundamental spinor field on the surrounding spacetime geometry. We show that despite the lack of a rotating stress-energy source (and despite claims to the contrary) the intrinsic spin of a spin-half fermion gives rise to a frame-dragging effect analogous to that of orbital angular momentum, even in Einstein-Hilbert gravity where torsion is constrained to be zero. This resolves a paradox regarding the counter-force needed to restore Newton's third law in the well-known spin-orbit interaction. In addition, the frame-dragging effect gives rise to a long-range gravitationally mediated spin-spin dipole interaction coupling the internal spins of two sources. We argue that despite the weakness of the interaction, the spin-spin interaction will dominate over the ordinary inverse square Newtonian interaction in any process of sufficiently high energy for quantum field theoretical effects to be non-negligible.

  19. Exotic dual of type II double field theory

    Directory of Open Access Journals (Sweden)

    Eric A. Bergshoeff

    2017-04-01

    Full Text Available We perform an exotic dualization of the Ramond–Ramond fields in type II double field theory, in which they are encoded in a Majorana–Weyl spinor of O(D,D. Starting from a first-order master action, the dual theory in terms of a tensor–spinor of O(D,D is determined. This tensor–spinor is subject to an exotic version of the (self-duality constraint needed for a democratic formulation. We show that in components, reducing O(D,D to GL(D, one obtains the expected exotically dual theory in terms of mixed Young tableaux fields. To this end, we generalize exotic dualizations to self-dual fields, such as the 4-form in type IIB string theory.

  20. Nonlinear Spinor Field in Non-Diagonal Bianchi Type Space-Time

    Directory of Open Access Journals (Sweden)

    Saha Bijan

    2018-01-01

    Full Text Available Within the scope of the non-diagonal Bianchi cosmological models we have studied the role of the spinor field in the evolution of the Universe. In the non-diagonal Bianchi models the spinor field distribution along the main axis is anisotropic and does not vanish in the absence of the spinor field nonlinearity. Hence within these models perfect fluid, dark energy etc. cannot be simulated by the spinor field nonlinearity. The equation for volume scale V in the case of non-diagonal Bianchi models contains a term with first derivative of V explicitly and does not allow exact solution by quadratures. Like the diagonal models the non-diagonal Bianchi space-time becomes locally rotationally symmetric even in the presence of a spinor field. It was found that depending on the sign of the coupling constant the model allows either an open Universe that rapidly grows up or a close Universe that ends in a Big Crunch singularity.

  1. Tramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trial

    Science.gov (United States)

    Rawal, Narinder; Macquaire, Valery; Catalá, Elena; Berti, Marco; Costa, Rui; Wietlisbach, Markus

    2011-01-01

    This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after surgery, and every 6 hours after discharge until midnight of the first postoperative day. Analgesic efficacy was assessed by patients (n = 128 in each group, full analysis set) and recorded in a diary on the evening of surgery day and of the first postoperative day. They also documented the occurrence of adverse events. By the end of the first postoperative day, the proportion of treatment responders based on treatment satisfaction (primary efficacy variable) was comparable between the groups (78.1% combination, 71.9% tramadol; P = 0.24) and mean pain intensity (rated on a numerical scale from 0 = no pain to 10 = worst imaginable pain) had been reduced to 1.7 ± 2.0 for both groups. Under both treatments, twice as many patients experienced no pain (score = 0) on the first postoperative day compared to the day of surgery (35.9% vs 16.4% for tramadol/paracetamol and 36.7% vs 18% for tramadol treatment). Rescue medication leading to withdrawal (diclofenac 50 mg) was required by 17.2% patients with tramadol/paracetamol and 13.3% with tramadol. Adverse events (mainly nausea, dizziness, somnolence, vomiting, and increased sweating) occurred less frequently in patients under combination treatment (P = 0.004). Tramadol/paracetamol combination tablets provided comparable analgesic efficacy with a better safety profile to tramadol capsules in patients experiencing postoperative pain following ambulatory hand surgery. PMID:21559356

  2. A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

    OpenAIRE

    Hong, Zehui; Jiang, Jie; Lan, Li; Nakajima, Satoshi; Kanno, Shin-ichiro; Koseki, Haruhiko; Yasui, Akira

    2008-01-01

    DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or nonhomologous end-joining processes. Although many proteins have been identified to participate in either of the processes, the whole processes still remain elusive. Polycomb group (PcG) proteins are epigenetic chromatin modifiers involved in gene silencing, cancer development and the maintenance of embry...

  3. Off-shell spinor-helicity amplitudes from light-cone deformation procedure

    Energy Technology Data Exchange (ETDEWEB)

    Ponomarev, Dmitry [Theoretical physics group, Blackett Laboratory, Imperial College London,London, SW7 2AZ (United Kingdom)

    2016-12-22

    We study the consistency conditions for interactions of massless fields of any spin in four-dimensional flat space using the light-cone approach. We show that they can be equivalently rewritten as the Ward identities for the off-shell light-cone amplitudes built from the light-cone Hamiltonian in the standard way. Then we find a general solution of these Ward identities. The solution admits a compact representation when written in the spinor-helicity form and is given by an arbitrary function of spinor products, satisfying well-known homogeneity constraints. Thus, we show that the light-cone consistent deformation procedure inevitably leads to a certain off-shell version of the spinor-helicity approach. We discuss how the relation between the two approaches can be employed to facilitate the search of consistent interaction of massless higher-spin fields.

  4. Global positioning of spin GPS scheme for half-spin massive spinors

    CERN Document Server

    Jadach, Stanislaw; Was, Zbigniew

    2001-01-01

    We present a simple and flexible method of keeping track of the complex phases and spin quantisation axes for half-spin initial- and final-state Weyl spinors in scattering amplitudes of Standard Model high energy physics processes. Both cases of massless and massive spinors are discussed. The method is demonstrated and checked numerically for spin correlations in tau tau production and decay. Its application is in our work of combining effects due to multiple photon emission (exponentiation) and spin, embodied in the Monte Carlo event generators for production and decay of unstable fermions such as the, tau lepton, t-quark and hypothetical new heavy particles. In particular, the recurrent problem of combining, for such unstable fermions, one author's calculation of production and another author's calculation of decay, in the presence or absence of multiple photon effects, is there given a practical solution, both for Weyl spinor methods and for the traditional Jacob-Wick helicity methods. Moreover, for massiv...

  5. Killing spinors for the bosonic string and Kaluza-Klein theory with scalar potentials

    International Nuclear Information System (INIS)

    Liu, Haishan; Lue, H.; Wang, Zhao-Long

    2012-01-01

    The paper consists mainly of two parts. In the first part, we obtain well-defined Killing spinor equations for the low-energy effective action of the bosonic string with the conformal anomaly term. We show that the conformal anomaly term is the only scalar potential that one can add into the action that is consistent with the Killing spinor equations. In the second part, we demonstrate that Kaluza-Klein theory can be gauged so that the Killing spinors are charged under the Kaluza-Klein vector. This gauging process generates a scalar potential with a maximum that gives rise to an AdS spacetime. We also construct solutions of these theories. (orig.)

  6. Non-Schwinger solution of the two-dimensional massless spinor electrodynamics

    International Nuclear Information System (INIS)

    Mikhov, S.G.

    1981-01-01

    In the present paper a regularization procedure is formulated for the current in the two-dimensional massless spinor electrodynamics that is both gauge and γ 5 -gauge invariant. This gives rise to an operator solution of the model that does not involve a massive photon. The latter solution is studied in some detail, and it is shown that although a charge operator exists, it does not define the electric charge of the spinor field. This can be a manifestation of the charge screening mechanism that is present in the Schwinger model [ru

  7. Nonadiabatic production of spinor condensates with a quadrupole-Ioffe-configuration trap

    International Nuclear Information System (INIS)

    Zhang, P.; Xu, Z.; You, L.

    2006-01-01

    Motivated by the recent experimental observation of multicomponent spinor condensates via a time-dependent quadrupole-Ioffe-configuration trap, we provide a general framework for the investigation of nonadiabatic Landau-Zener dynamics of a hyperfine spin, e.g., from an atomic magnetic dipole moment coupled to a weak time-dependent magnetic (B-) field. The spin flipped population distribution, or the so-called Majorona formula, is expressed in terms of system parameters and experimental observables; thus, the distribution provides much needed insight into the underlying mechanism for the production of spinor condensates due to nonadiabatic level crossings

  8. Lecture in Honour of Leopold Infeld (Extended Outline Only) Spinors in General Relativity

    International Nuclear Information System (INIS)

    Penrose, R. sir

    1999-01-01

    This article is an extended outline of the lecture delivered at the Infeld Centennial Meeting. In the lecture a review was given of the development of the theory of spinors and related objects in special and general relativity, with some emphasis on the twistor theory and its applications. The lecture was not intended as a detailed account of the subject, but it rather was a series of comments on the relevance of various spinor-type objects and their relation to some features of space-time structure. The present article is also a guide, with its author's personal preferences, to the extensive bibliography of the subject. (author)

  9. Magnetic resonance, especially spin echo, in spinor Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Yasunaga, Masashi; Tsubota, Makoto

    2009-01-01

    Magnetic resonance, especially NMR and ESR, has been studied in magnetic materials for a long time, having been used in various fields. Spin echo is typical phenomenon in magnetic resonance. The magnetic resonance should be applied to spinor Bose-Einstein condensates (BECs). We numerically study spin echo of a spinor BEC in a gradient magnetic field by calculating the spin-1 two-dimensional Gross-Pitaevskii equations, obtaining the recovery of the signal of the spins, which is called spin echo. We will discuss the relation between the spin echo and the Stern-Gelrach separation in the system.

  10. Y-formalism and b ghost in the non-minimal pure spinor formalism of superstrings

    International Nuclear Information System (INIS)

    Oda, Ichiro; Tonin, Mario

    2007-01-01

    We present the Y-formalism for the non-minimal pure spinor quantization of superstrings. In the framework of this formalism we compute, at the quantum level, the explicit form of the compound operators involved in the construction of the b ghost, their normal-ordering contributions and the relevant relations among them. We use these results to construct the quantum-mechanical b ghost in the non-minimal pure spinor formalism. Moreover we show that this non-minimal b ghost is cohomologically equivalent to the non-covariant b ghost

  11. On a modification of the spinor calculus of Infeeld and van der Waerden

    International Nuclear Information System (INIS)

    Buchdahl, H.A.

    1990-01-01

    A modification of the spinor calculus of Infeeld and van der Waerden is presented in which σ kμν is no longer covariant constant. The structure of spin space is enriched by a spinor f μνρσ defined on it. Flatness of the Riemannian world space no longer necessarily entails the vanishing of the curvature of the spin space. After a brief look at Dirac's equation, the revised calculus is re-interpreted in terms of a Riemann-Cartan space, with σ kμν again covariant constant. (author)

  12. One-particle reducible contribution to the one-loop spinor propagator in a constant field

    Directory of Open Access Journals (Sweden)

    N. Ahmadiniaz

    2017-11-01

    Full Text Available Extending work by Gies and Karbstein on the Euler–Heisenberg Lagrangian, it has recently been shown that the one-loop propagator of a charged scalar particle in a constant electromagnetic field has a one-particle reducible contribution in addition to the well-studied irreducible one. Here we further generalize this result to the spinor case, and find the same relation between the reducible term, the tree-level propagator and the one-loop Euler–Heisenberg Lagrangian as in the scalar case. Our demonstration uses a novel worldline path integral representation of the photon-dressed spinor propagator in a constant electromagnetic field background.

  13. Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex.

    Science.gov (United States)

    Noll, Meenakshi; Battaile, Kevin P; Bateman, Raynard; Lax, Timothy P; Rathbun, Keany; Reifsteck, Carol; Bagby, Grover; Finegold, Milton; Olson, Susan; Grompe, Markus

    2002-07-01

    Fanconi anemia (FA) is a genetically heterogeneous disorder associated with defects in at least eight genes. The biochemical function(s) of the FA proteins are unknown, but together they define the FA pathway, which is involved in cellular responses to DNA damage and in other cellular processes. It is currently unknown whether all FA proteins are involved in controlling a single function or whether some of the FA proteins have additional roles. The aim of this study was 1) to determine whether the FA group A and group C genes have identical or partially distinct functions, and 2) to have a better model for human FA. We generated mice with a targeted mutation in fanca and crossed them with fancc disrupted animals. Several phenotypes including sensitivity to DNA cross linkers and ionizing radiation, hematopoietic colony growth, and germ cell loss were analyzed in fanca-/-, fancc-/-, fanca/fancc double -/-, and controls. Fibroblast cells and hematopoietic precursors from fanca/fancc double-mutant mice were not more sensitive to MMC than those of either single mutant. fanca/fancc double mutants had no evidence for an additive phenotype at the cellular or organismal level. These results support a model where both FANCA and FANCC are part of a multi-protein nuclear FA complex with identical function in cellular responses to DNA damage and germ cell survival.

  14. Tramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trial

    Directory of Open Access Journals (Sweden)

    Rawal N

    2011-04-01

    Full Text Available Narinder Rawal1, Valery Macquaire2, Elena Catalá3, Marco Berti4, Rui Costa5, Markus Wietlisbach61Department of Anesthesiology and Intensive Care, Örebro University Hospital, Örebro, Sweden; 2Clinique du Parc Leopold, Brussels, Belgium; 3Pain Clinic, Department Anesthesiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 4Department of Anesthesiology and Reanimation, Parma Hospital, Parma, Italy; 5Garcia de Orta Hospital, Almada, Portugal; 6Department of Anesthesiology, Sursee Hospital, Sursee, SwitzerlandAbstract: This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after surgery, and every 6 hours after discharge until midnight of the first postoperative day. Analgesic efficacy was assessed by patients (n = 128 in each group, full analysis set and recorded in a diary on the evening of surgery day and of the first postoperative day. They also documented the occurrence of adverse events. By the end of the first postoperative day, the proportion of treatment responders based on treatment satisfaction (primary efficacy variable was comparable between the groups (78.1% combination, 71.9% tramadol; P = 0.24 and mean pain intensity (rated on a numerical scale from 0 = no pain to 10 = worst imaginable pain had been reduced to 1.7 ± 2.0 for both groups. Under both treatments, twice as many patients experienced no pain (score = 0 on the first postoperative day compared to the day of surgery (35.9% vs 16.4% for tramadol/paracetamol and 36.7% vs 18% for tramadol treatment. Rescue medication leading to withdrawal (diclofenac 50 mg was required by 17.2% patients with tramadol/paracetamol and 13.3% with tramadol. Adverse events (mainly nausea, dizziness

  15. Spin factor and spinor structure of Dirac propagator in constant field

    Energy Technology Data Exchange (ETDEWEB)

    Gitman, D.M.; Cruz, W. da [Sao Paulo Univ., SP (Brazil). Inst. de Fisica; Zlatev, S.I. [Sergipe Univ., Aracaju, SE (Brazil). Dept. de Fisica

    1996-06-01

    We use bosonic path integral representation of Dirac propagator with a spin factor to calculate the propagator in a constant uniform electromagnetic field. Such a way of calculation allows us to get the explicit spinor structure of the propagator in the case under consideration. The representation obtained differs from the Schwinger`s one but the equivalence can be checked. (author). 21 refs.

  16. Spin factor and spinor structure of Dirac propagator in constant field

    International Nuclear Information System (INIS)

    Gitman, D.M.; Cruz, W. da; Zlatev, S.I.

    1996-01-01

    We use bosonic path integral representation of Dirac propagator with a spin factor to calculate the propagator in a constant uniform electromagnetic field. Such a way of calculation allows us to get the explicit spinor structure of the propagator in the case under consideration. The representation obtained differs from the Schwinger's one but the equivalence can be checked. (author). 21 refs

  17. Gauge-invariant approach and infrared behaviour of the spinor propagator

    International Nuclear Information System (INIS)

    Sisakyan, A.N.; Skachkov, N.B.; Solovtsov, I.L.; Shevchenko, O.Yu.

    1989-01-01

    Infrared behaviour of the gauge-invariant spinor propagator is studied. It is proved that infrared peculiarities of such a propagator can be factorized in a form of the Wilson loop that includes only the slowly varying component of electromagnetic field and accumulates all the dependence of the initial Green function of the form of the path

  18. Weyl-van der Waerden spinor technic for spin-3/2 fermions

    International Nuclear Information System (INIS)

    Novaes, S.F.; Spehler, D.

    1991-09-01

    We use the Weyl-van der Waerden spinor technic to construct helicity wave functions for massless and massive spin-3/2 fermions. We apply our formalism to evaluate helicity amplitudes taking into account some phenomenological couplings involving these particles. (author)

  19. The non-minimal heterotic pure spinor string in a curved background

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Facultad de Artes Liberales and Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile)

    2014-03-21

    We study the non-minimal pure spinor string in a curved background. We find that the minimal BRST invariance implies the existence of a non-trivial stress-energy tensor for the minimal and non-minimal variables in the heterotic curved background. We find constraint equations for the b ghost. We construct the b ghost as a solution of these constraints.

  20. Simplified pure spinor b ghost in a curved heterotic superstring background

    Energy Technology Data Exchange (ETDEWEB)

    Berkovits, Nathan [ICTP South American Institute for Fundamental Research,Instituto de Física Teórica, UNESP - Universidade Estadual Paulista,Rua Dr. Bento T. Ferraz 271, 01140-070, São Paulo, SP (Brazil); Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile)

    2014-06-03

    Using the RNS-like fermionic vector variables introduced in arXiv:1305.0693, the pure spinor b ghost in a curved heterotic superstring background is easily constructed. This construction simplifies and completes the b ghost construction in a curved background of arXiv:1311.7012.

  1. A Double-Deck Elevator Group Supervisory Control System with Destination Floor Guidance System Using Genetic Network Programming

    Science.gov (United States)

    Yu, Lu; Zhou, Jin; Mabu, Shingo; Hirasawa, Kotaro; Hu, Jinglu; Markon, Sandor

    The Elevator Group Supervisory Control Systems (EGSCS) are the control systems that systematically manage three or more elevators in order to efficiently transport the passengers in buildings. Double-deck elevators, where two elevators are connected with each other, serve passengers at two consecutive floors simultaneously. Double-deck Elevator systems (DDES) become more complex in their behavior than conventional single-deck elevator systems (SDES). Recently, Artificial Intelligence (AI) technology has been used in such complex systems. Genetic Network Programming (GNP), a graph-based evolutionary method, has been applied to EGSCS and its advantages are shown in some papers. GNP can obtain the strategy of a new hall call assignment to the optimal elevator when it performs crossover and mutation operations to judgment nodes and processing nodes. Meanwhile, Destination Floor Guidance System (DFGS) is installed in DDES, so that passengers can also input their destinations at elevator halls. In this paper, we have applied GNP to DDES and compared DFGS with normal systems. The waiting time and traveling time of DFGS are all improved because of getting more information from DFGS. The simulations showed the effectiveness of the double-deck elevators with DFGS in different building traffics.

  2. One-, two- and three-dimensional transport codes using multi-group double-differential form cross sections

    International Nuclear Information System (INIS)

    Mori, Takamasa; Nakagawa, Masayuki; Sasaki, Makoto.

    1988-11-01

    We have developed a group of computer codes to realize the accurate transport calculation by using the multi-group double-differential form cross section. This type of cross section can correctly take account of the energy-angle correlated reaction kinematics. Accordingly, the transport phenomena in materials with highly anisotropic scattering are accurately calculated by using this cross section. They include the following four codes or code systems: PROF-DD : a code system to generate the multi-group double-differential form cross section library by processing basic nuclear data file compiled in the ENDF / B-IV or -V format, ANISN-DD : a one-dimensional transport code based on the discrete ordinate method, DOT-DD : a two-dimensional transport code based on the discrete ordinate method, MORSE-DD : a three-dimensional transport code based on the Monte Carlo method. In addition to these codes, several auxiliary codes have been developed to process calculated results. This report describes the calculation algorithm employed in these codes and how to use them. (author)

  3. Generalized zeta function representation of groups and 2-dimensional topological Yang-Mills theory: The example of GL(2, #Mathematical Double-Struck Capital F#{sub q}) and PGL(2, #Mathematical Double-Struck Capital F#{sub q})

    Energy Technology Data Exchange (ETDEWEB)

    Roche, Ph., E-mail: philippe.roche@univ-montp2.fr [Université Montpellier 2, CNRS, L2C, IMAG, Montpellier (France)

    2016-03-15

    We recall the relation between zeta function representation of groups and two-dimensional topological Yang-Mills theory through Mednikh formula. We prove various generalisations of Mednikh formulas and define generalization of zeta function representations of groups. We compute some of these functions in the case of the finite group GL(2, #Mathematical Double-Struck Capital F#{sub q}) and PGL(2, #Mathematical Double-Struck Capital F#{sub q}). We recall the table characters of these groups for any q, compute the Frobenius-Schur indicator of their irreducible representations, and give the explicit structure of their fusion rings.

  4. Supersymmetry for gauged double field theory and generalised Scherk–Schwarz reductions

    International Nuclear Information System (INIS)

    Berman, David S.; Lee, Kanghoon

    2014-01-01

    Previous constructions of supersymmetry for double field theory have relied on the so-called strong constraint. In this paper, the strong constraint is relaxed and the theory is shown to possess supersymmetry once the generalised Scherk–Schwarz reduction is imposed. The equivalence between the generalised Scherk–Schwarz reduced theory and the gauged double field theory is then examined in detail for the supersymmetric theory. As a biproduct we write the generalised Killing spinor equations for the supersymmetric double field theory

  5. Effect of Strong Acid Functional Groups on Electrode Rise Potential in Capacitive Mixing by Double Layer Expansion

    KAUST Repository

    Hatzell, Marta C.; Raju, Muralikrishna; Watson, Valerie J.; Stack, Andrew G.; van Duin, Adri C. T.; Logan, Bruce E.

    2014-01-01

    © 2014 American Chemical Society. The amount of salinity-gradient energy that can be obtained through capacitive mixing based on double layer expansion depends on the extent the electric double layer (EDL) is altered in a low salt concentration (LC) electrolyte (e.g., river water). We show that the electrode-rise potential, which is a measure of the EDL perturbation process, was significantly (P = 10-5) correlated to the concentration of strong acid surface functional groups using five types of activated carbon. Electrodes with the lowest concentration of strong acids (0.05 mmol g-1) had a positive rise potential of 59 ± 4 mV in the LC solution, whereas the carbon with the highest concentration (0.36 mmol g-1) had a negative rise potential (-31 ± 5 mV). Chemical oxidation of a carbon (YP50) using nitric acid decreased the electrode rise potential from 46 ± 2 mV (unaltered) to -6 ± 0.5 mV (oxidized), producing a whole cell potential (53 ± 1.7 mV) that was 4.4 times larger than that obtained with identical electrode materials (from 12 ± 1 mV). Changes in the EDL were linked to the behavior of specific ions in a LC solution using molecular dynamics and metadynamics simulations. The EDL expanded in the LC solution when a carbon surface (pristine graphene) lacked strong acid functional groups, producing a positive-rise potential at the electrode. In contrast, the EDL was compressed for an oxidized surface (graphene oxide), producing a negative-rise electrode potential. These results established the linkage between rise potentials and specific surface functional groups (strong acids) and demonstrated on a molecular scale changes in the EDL using oxidized or pristine carbons.

  6. Effect of Strong Acid Functional Groups on Electrode Rise Potential in Capacitive Mixing by Double Layer Expansion

    KAUST Repository

    Hatzell, Marta C.

    2014-12-02

    © 2014 American Chemical Society. The amount of salinity-gradient energy that can be obtained through capacitive mixing based on double layer expansion depends on the extent the electric double layer (EDL) is altered in a low salt concentration (LC) electrolyte (e.g., river water). We show that the electrode-rise potential, which is a measure of the EDL perturbation process, was significantly (P = 10-5) correlated to the concentration of strong acid surface functional groups using five types of activated carbon. Electrodes with the lowest concentration of strong acids (0.05 mmol g-1) had a positive rise potential of 59 ± 4 mV in the LC solution, whereas the carbon with the highest concentration (0.36 mmol g-1) had a negative rise potential (-31 ± 5 mV). Chemical oxidation of a carbon (YP50) using nitric acid decreased the electrode rise potential from 46 ± 2 mV (unaltered) to -6 ± 0.5 mV (oxidized), producing a whole cell potential (53 ± 1.7 mV) that was 4.4 times larger than that obtained with identical electrode materials (from 12 ± 1 mV). Changes in the EDL were linked to the behavior of specific ions in a LC solution using molecular dynamics and metadynamics simulations. The EDL expanded in the LC solution when a carbon surface (pristine graphene) lacked strong acid functional groups, producing a positive-rise potential at the electrode. In contrast, the EDL was compressed for an oxidized surface (graphene oxide), producing a negative-rise electrode potential. These results established the linkage between rise potentials and specific surface functional groups (strong acids) and demonstrated on a molecular scale changes in the EDL using oxidized or pristine carbons.

  7. Infrared asymptotics and Dyson-Schwinger equations for the gauge-invariant spinor Green function in quantum electrodynamics

    International Nuclear Information System (INIS)

    Skachkov, N.B.; Solovtsov, I.L.; Shevchenko, O.Yu.

    1985-01-01

    The Dayson-Schwinger equations for the gauge-invariant (G.I.) spinor Green function are derived for an Abelian case. On the basis of these equations as well as the functional integration method the behaviour of the G.I. spinor propagator is studied in the infrared region. It is shown that the G.I. propagator has a singularity of a simple pole in this region

  8. Double-blind, parallel-group evaluation of etodolac and naproxen in patients with acute sports injuries.

    Science.gov (United States)

    D'Hooghe, M

    1992-01-01

    The efficacy and safety of etodolac and naproxen were compared in a double-blind, randomized, parallel-group outpatient study. Patients with acute sports injuries were assigned to receive either etodolac 300 mg TID (50 patients) or naproxen 500 mg BID (49 patients) for up to 7 days. Assessments were made at the pretreatment screening (baseline) and at days 2, 3, 4, and 7 of treatment. Assessments included patient and physician global evaluations, spontaneous and induced pain intensity, range of motion, tenderness, heat, degree of swelling, and degree of erythema. Safety assessments, including laboratory profiles, were made at pretreatment and at final evaluation; patients' complaints were elicited at all visits. Both treatment groups showed significant (P less than or equal to 0.05) improvement from baseline for all efficacy parameters by day 2 and thereafter at all time points. Improvement was similar for the two groups. No patients in either group withdrew from the study because of drug-related adverse reactions. The results of this study indicate that etodolac (900 mg/day) is effective and well tolerated as an analgesic and anti-inflammatory in acute sports injuries and is comparable to naproxen (1000 mg/day).

  9. Multiloop amplitudes and vanishing theorems using the pure spinor formalism for the superstring

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2004-01-01

    A ten-dimensional super-Poincare covariant formalism for the superstring was recently developed which involves a BRST operator constructed from superspace matter variables and a pure spinor ghost variable. A super-Poincare covariant prescription was defined for computing tree amplitudes and was shown to coincide with the standard RNS prescription. In this paper, picture-changing operators are used to define functional integration over the pure spinor ghosts and to construct a suitable b ghost. A super-Poincare covariant prescription is then given for the computation of N-point multiloop amplitudes. One can easily prove that massless N-point multiloop amplitudes vanish for N 4 terms in the effective action receive no perturbative contributions above one loop. (author)

  10. SO(d,d) transformations of Ramond-Ramond fields and space-time spinors

    International Nuclear Information System (INIS)

    Hassan, S.F.

    2000-01-01

    We explicitly construct the SO(d,d) transformations of Ramond-Ramond field strengths and potentials, along with those of the space-time supersymmetry parameters, the gravitinos and the dilatinos in type-II theories. The results include the case when the SO(d,d) transformation involves the time direction. The derivation is based on the compatibility of SO(d,d) transformations with space-time supersymmetry, which automatically guarantees compatibility with the equations of motion. It involves constructing the spinor representation of a twist that an SO(d,d) action induces between the local Lorentz frames associated with the left- and right-moving sectors of the worldsheet theory. The relation to the transformation of R-R potentials as SO(d,d) spinors is also clarified

  11. Towards exact solutions of the non-linear Heisenberg-Pauli-Weyl spinor equation

    International Nuclear Information System (INIS)

    Mielke, E.W.

    1980-03-01

    In ''color geometrodynamics'' fundamental spinor fields are assumed to obey a GL(2f,C) x GL(2c,C) gauge-invariant nonlinear spinor equation of the Heisenberg-Pauli-Weyl type. Quark confinement, assimilating a scheme of Salam and Strathdee, is (partially) mediated by the tensor ''gluons'' of strong gravity. This hypothesis is incorporated into the model by considering the nonlinear Dirac equation in a curved space-time of hadronic dimensions. Disregarding internal degrees of freedom, it is then feasible, for a particular background space-time, to obtain exact solutions of the spherical bound-state problem. Finally, these solutions are tentatively interpreted as droplet-type solitons and remarks on their interrelation with Wheeler's geon construction are made. (author)

  12. Exact solutions to the nonlinear spinor field equations in the Goedel universe

    International Nuclear Information System (INIS)

    Herrera, A.

    1996-01-01

    The nonlinear spinor field in the external gravitational field of the Goedel universe is considered and exact static solutions to the field equations corresponding to the Lagrangians with the nonlinear terms L N =F(I S ) and L N =G(I P ) are obtained. Here F(I S ) and G(I P ) are arbitrary functions of the spinor invariants I S =S+Ψ bar Ψ and I P =P 2 =(iΨ bar γ 5 Ψ) 2 . The conditions under which one-dimensional soliton-like solutions exist are established and the role of gravity in the formation of these objects is determined. 9 refs., 1 fig

  13. Coherent magnon optics in a ferromagnetic spinor Bose-Einstein condensate.

    Science.gov (United States)

    Marti, G Edward; MacRae, Andrew; Olf, Ryan; Lourette, Sean; Fang, Fang; Stamper-Kurn, Dan M

    2014-10-10

    We measure the dispersion relation, gap, and magnetic moment of a magnon in the ferromagnetic F = 1 spinor Bose-Einstein condensate of (87)Rb. From the dispersion relation we measure an average effective mass 1.033(2)(stat)(10)(sys) times the atomic mass, as determined by interfering standing and running coherent magnon waves within the dense and trapped condensed gas. The measured mass is higher than theoretical predictions of mean-field and beyond-mean-field Beliaev theory for a bulk spinor Bose gas with s-wave contact interactions. We observe a magnon energy gap of h × 2.5(1)(stat)(2)(sys) Hz, which is consistent with the predicted effect of magnetic dipole-dipole interactions. These dipolar interactions may also account for the high magnon mass. The effective magnetic moment of -1.04(2)(stat)(8)(sys) times the atomic magnetic moment is consistent with mean-field theory.

  14. Population and phase dynamics of F=1 spinor condensates in an external magnetic field

    International Nuclear Information System (INIS)

    Romano, D.R.; Passos, E.J.V. de

    2004-01-01

    We show that the classical dynamics underlying the mean-field description of homogeneous mixtures of spinor F=1 Bose-Einstein condensates in an external magnetic field is integrable as a consequence of number conservation and axial symmetry in spin space. The population dynamics depends only on the quadratic term of the Zeeman energy and on the strength of the spin-dependent term of the atom-atom interaction. We determine the equilibrium populations as function of the ratio of these two quantities and the miscibility of the hyperfine components in the ground state spinors are thoroughly discussed. Outside the equilibrium, the populations are always a periodic function of time where the periodic motion can be a libration or a rotation. Our studies also indicate the absence of metastability

  15. U(N) tools for loop quantum gravity: the return of the spinor

    Science.gov (United States)

    Borja, Enrique F.; Freidel, Laurent; Garay, Iñaki; Livine, Etera R.

    2011-03-01

    We explore the classical setting for the U(N) framework for SU(2) intertwiners for loop quantum gravity and describe the corresponding phase space in terms of spinors with the appropriate constraints. We show how its quantization leads back to the standard Hilbert space of intertwiner states defined as holomorphic functionals. We then explain how to glue these intertwiners states in order to construct spin network states as wavefunctions on the spinor phase space. In particular, we translate the usual loop gravity holonomy observables to our classical framework. Finally, we propose how to derive our phase space structure from an action principle which induces non-trivial dynamics for the spin network states. We conclude by applying explicitly our framework to states living on the simple 2-vertex graph and discuss the properties of the resulting Hamiltonian.

  16. Real-time response in AdS/CFT with application to spinors

    International Nuclear Information System (INIS)

    Iqbal, N.; Liu, H.

    2009-01-01

    We discuss a simple derivation of the real-time AdS/CFT prescription as an analytic continuation of the corresponding problem in Euclidean signature. We then extend the formalism to spinor operators and apply it to the examples of real-time fermionic correlators in CFTs dual to pure AdS and the BTZ black hole. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  17. Nucleon-nucleon scattering in the functional quantum theory of the nonlinear spinor field

    International Nuclear Information System (INIS)

    Haegele, G.

    1979-01-01

    The author calculates the S matrix for the elastic nucleon-nucleon scattering in the lowest approximation using the quantum theory of nonlinear spinor fields with special emphasis to the ghost configuration of this theory. Introducing a general scalar product a new functional channel calculus is considered. From the results the R and T matrix elements and the differential and integral cross sections are derived. (HSI)

  18. Non-existence of rest-frame spin-eigenstate spinors in their own electrodynamics

    Science.gov (United States)

    Fabbri, Luca; da Rocha, Roldão

    2018-05-01

    We assume a physical situation where gravity with torsion is neglected for an electrodynamically self-interacting spinor that will be taken in its rest-frame and spin-eigenstate: we demonstrate that under this circumstance no solution exists for the system of field equations. Despite such a situation might look artificial nevertheless it represents the instance that is commonly taken as the basis for all computations of quantum electrodynamics.

  19. The lattice spinor QED Hamiltonian critique of the continuous space approach

    International Nuclear Information System (INIS)

    Sidorov, A.V.; Zastavenko, L.G.

    1993-01-01

    We give the irreproachable, from the point of view of gauge invariance, derivation of the lattice spinor QED Hamiltonian. Our QED Hamiltonian is manifestly gauge invariant. We point out important defects of the continuous space formulation of the QED that make, in our opinion, the lattice QED obviously preferable to the continuous space QED. We state that it is impossible to give a continuous space QED formulation which is compatible with the condition of gauge invariance. 17 refs

  20. Tailoring surface properties and structure of layered double hydroxides using silanes with different number of functional groups

    International Nuclear Information System (INIS)

    Tao, Qi; He, Hongping; Li, Tian; Frost, Ray L.; Zhang, Dan; He, Zisen

    2014-01-01

    Four silanes, trimethylchlorosilane (TMCS), dimethyldiethoxylsilane (DMDES), 3-aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS), were adopted to graft layered double hydroxides (LDH) via an induced hydrolysis silylation method (IHS). Fourier transform infrared spectra (FTIR) and 29 Si MAS nuclear magnetic resonance spectra ( 29 Si MAS NMR) indicated that APTES and TEOS can be grafted onto LDH surfaces via condensation with hydroxyl groups of LDH, while TMCS and DMDES could only be adsorbed on the LDH surface with a small quantity. A combination of X-ray diffraction patterns (XRD) and 29 Si MAS NMR spectra showed that silanes were exclusively present in the external surface and had little influence on the long range order of LDH. The surfactant intercalation experiment indicated that the adsorbed and/or grafted silane could not fix the interlamellar spacing of the LDH. However, they will form crosslink between the particles and affect the further surfactant intercalation in the silylated samples. The replacement of water by ethanol in the tactoids and/or aggregations and the polysiloxane oligomers formed during silylation procedure can dramatically increase the value of BET surface area (S BET ) and total pore volumes (V p ) of the products. - Graphical abstract: The replacement of water by ethanol in the tactoids and aggregations of LDHs, and the polysiloxane oligomers formed during silylation process can dramatically increase the BET surface area (S BET ) and the total pore volume (V p ) of the silylated products. - Highlights: • Silanes with multifunctional groups were grafted onto LDH surface in C 2 H 5 OH medium. • The number of hydrolysable groups in silanes affects the structure of grafted LDH. • Replacement of H 2 O by C 2 H 5 OH in aggregations increases S BET and V p of grafted LDH. • Polysiloxane oligomers contribute to the increase of S BET and V p of grafted LDH

  1. Relativistic double-zeta, triple-zeta, and quadruple-zeta basis sets for the lanthanides La–Lu

    NARCIS (Netherlands)

    Dyall, K.G.; Gomes, A.S.P.; Visscher, L.

    2010-01-01

    Relativistic basis sets of double-zeta, triple-zeta, and quadruple-zeta quality have been optimized for the lanthanide elements La-Lu. The basis sets include SCF exponents for the occupied spinors and for the 6p shell, exponents of correlating functions for the valence shells (4f, 5d and 6s) and the

  2. Polymorphic Variation in Double Strand Break Repair Gene in Indian Population: A Comparative Approach with Worldwide Ethnic Group Variations.

    Science.gov (United States)

    Mandal, Raju Kumar; Mittal, Rama Devi

    2018-04-01

    DNA repair capacity is essential in maintaining cellular functions and homeostasis. Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. Double strand break repair pathway plays critical roles in maintaining genome stability. Present study was conducted to determine distribution of XRCC3 Exon 7 (C18067T, rs861539) and XRCC7 Intron 8 (G6721T, rs7003908) gene polymorphisms in North Indian population and compare with different populations globally. The genotype assays were performed in 224 normal healthy individuals of similar ethnicity using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Allelic frequencies of wild type were 79% (C) in XRCC3 Exon 7 C > T and 57% (G) in XRCC7 Intron 8 (G > T) 57% (G) observed. On the other hand, the variant allele frequency were 21% (T) in XRCC3 Exon 7 C > T and 43% (T) in XRCC7 Intron 8 G > T respectively. Major differences from other ethnic populations were observed. Our results suggest that frequency in these DNA repair genes exhibit distinctive pattern in India that could be attributed to ethnicity variation. This could assist in high-risk screening of humans exposed to environmental carcinogens and cancer predisposition in different ethnic groups.

  3. Genetic variation in a DNA double strand break repair gene in saudi population: a comparative study with worldwide ethnic groups.

    Science.gov (United States)

    Areeshi, Mohammed Yahya

    2013-01-01

    DNA repair capacity is crucial in maintaining cellular functions and homeostasis. However, it can be altered based on DNA sequence variations in DNA repair genes and this may lead to the development of many diseases including malignancies. Identification of genetic polymorphisms responsible for reduced DNA repair capacity is necessary for better prevention. Homologous recombination (HR), a major double strand break repair pathway, plays a critical role in maintaining the genome stability. The present study was performed to determine the frequency of the HR gene XRCC3 Exon 7 (C18067T, rs861539) polymorphisms in Saudi Arabian population in comparison with epidemiological studies by "MEDLINE" search to equate with global populations. The variant allelic (T) frequency of XRCC3 (C>T) was found to be 39%. Our results suggest that frequency of XRCC3 (C>T) DNA repair gene exhibits distinctive patterns compared with the Saudi Arabian population and this might be attributed to ethnic variation. The present findings may help in high-risk screening of humans exposed to environmental carcinogens and cancer predisposition in different ethnic groups.

  4. A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

    Science.gov (United States)

    Hong, Zehui; Jiang, Jie; Lan, Li; Nakajima, Satoshi; Kanno, Shin-ichiro; Koseki, Haruhiko; Yasui, Akira

    2008-01-01

    DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or nonhomologous end-joining processes. Although many proteins have been identified to participate in either of the processes, the whole processes still remain elusive. Polycomb group (PcG) proteins are epigenetic chromatin modifiers involved in gene silencing, cancer development and the maintenance of embryonic and adult stem cells. By screening proteins responding to DNA damage using laser micro-irradiation, we found that PHF1, a human homolog of Drosophila polycomb-like, Pcl, protein, was recruited to DSBs immediately after irradiation and dissociated within 10 min. The accumulation at DSBs is Ku70/Ku80-dependent, and knockdown of PHF1 leads to X-ray sensitivity and increases the frequency of homologous recombination in HeLa cell. We found that PHF1 interacts physically with Ku70/Ku80, suggesting that PHF1 promotes nonhomologous end-joining processes. Furthermore, we found that PHF1 interacts with a number of proteins involved in DNA damage responses, RAD50, SMC1, DHX9 and p53, further suggesting that PHF1, besides the function in PcG, is involved in genome maintenance processes. PMID:18385154

  5. The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells.

    Science.gov (United States)

    Yang, Yun-Gui; Herceg, Zdenko; Nakanishi, Koji; Demuth, Ilja; Piccoli, Colette; Michelon, Jocelyne; Hildebrand, Gabriele; Jasin, Maria; Digweed, Martin; Wang, Zhao-Qi

    2005-10-01

    Fanconi anemia (FA) cells exhibit hypersensitivity to DNA interstrand cross-links (ICLs) and high levels of chromosome instability. FA gene products have been shown to functionally or physically interact with BRCA1, RAD51 and the MRE11/RAD50/NBS1 complex, suggesting that the FA complex may be involved in the repair of DNA double-strand breaks (DSBs). Here, we have investigated specifically the function of the FA group A protein (FANCA) in the repair of DSBs in mammalian cells. We show that the targeted deletion of Fanca exons 37-39 generates a null for Fanca in mice and abolishes ubiquitination of Fancd2, the downstream effector of the FA complex. Cells lacking Fanca exhibit increased chromosomal aberrations and attenuated accumulation of Brca1 and Rad51 foci in response to DNA damage. The absence of Fanca greatly reduces gene-targeting efficiency in mouse embryonic stem (ES) cells and compromises the survival of fibroblast cells in response to ICL agent treatment. Fanca-null cells exhibit compromised homology-directed repair (HDR) of DSBs, particularly affecting the single-strand annealing pathway. These data identify the Fanca protein as an integral component in the early step of HDR of DSBs and thereby minimizing the genomic instability.

  6. Cyclen-based double-tailed lipids for DNA delivery: Synthesis and the effect of linking group structures.

    Science.gov (United States)

    Zhang, Yi-Mei; Chang, De-Chun; Zhang, Ji; Liu, Yan-Hong; Yu, Xiao-Qi

    2015-09-01

    The gene transfection efficiency (TE) of cationic lipids is largely influenced by the lipid structure. Six novel 1, 4, 7, 10-tetraazacyclododecane (cyclen)-based cationic lipids L1-L6, which contain double oleyl as hydrophobic tails, were designed and synthesized. The difference between these lipids is their diverse backbone. Liposomes prepared by the lipids and DOPE showed good DNA affinity, and full DNA condensation could be achieved at N/P of 4 to form lipoplexes with proper size and zeta-potentials for gene transfection. Structure-activity relationship of these lipids as non-viral gene delivery vectors was investigated. It was found that minor backbone structural variations, including linking group and the structural symmetry would affect the TE. The diethylenetriamine derived lipid L4 containing amide linking bonds gave the best TE, which was several times higher than commercially available transfection reagent lipofectamine 2000. Besides, these lipids exhibited low cytotoxicity, suggesting their good biocompatibility. Results reveal that such type of cationic lipids might be promising non-viral gene vectors, and also afford us clues for the design of novel vectors with higher TE and biocompatibility. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study.

    Science.gov (United States)

    Zheng, Jinping; Yang, Jinghua; Zhou, Xiangdong; Zhao, Li; Hui, Fuxin; Wang, Haoyan; Bai, Chunxue; Chen, Ping; Li, Huiping; Kang, Jian; Brose, Manja; Richard, Frank; Goehring, Udo-Michael; Zhong, Nanshan

    2014-01-01

    Roflumilast is the only oral phosphodiesterase 4 inhibitor indicated for use in the treatment of COPD. Previous studies of roflumilast have predominantly involved European and North American populations. A large study was necessary to determine the efficacy and safety of roflumilast in a predominantly ethnic Chinese population. In a placebo-controlled, double-blind, parallel-group, multicenter, phase 3 study, patients of Chinese, Malay, and Indian ethnicity (N = 626) with severe to very severe COPD were randomized 1:1 to receive either roflumilast 500 μg once daily or placebo for 24 weeks. The primary end point was change in prebronchodilator FEV1 from baseline to study end. Three hundred thirteen patients were assigned to each treatment. Roflumilast provided a sustained increase over placebo in mean prebronchodilator FEV1 (0.071 L; 95% CI, 0.046, 0.095 L; P < .0001). Similar improvements were observed in the secondary end points of postbronchodilator FEV1 (0.068 L; 95% CI 0.044, 0.092 L; P < .0001) and prebronchodilator and postbronchodilator FVC (0.109 L; 95% CI, 0.061, 0.157 L; P < .0001 and 0.101 L; 95% CI, 0.055, 0.146 L; P < .0001, respectively). The adverse event profile was consistent with previous roflumilast studies. The most frequently reported treatment-related adverse event was diarrhea (6.0% and 1.0% of patients in the roflumilast and placebo groups, respectively). Roflumilast plays an important role in lung function improvement and is well tolerated in an Asian population. It provides an optimal treatment choice for patients with severe to very severe COPD.

  8. Free fields on the Poincare group

    Energy Technology Data Exchange (ETDEWEB)

    Toller, M; Vanzo, L [Dipartimento di Matematica e Fisica della Libera Universita di Trento, Italy

    1978-07-01

    Using a general formalism the tensor and spinor free fields as fields defined on the Poincare group manifold is treated. From an action principle it is deduced, besides the usual Klein-Gordon or Dirac equations, also the equations which describe the transformation properties of the fields under proper Lorentz transformations.

  9. Tailoring surface properties and structure of layered double hydroxides using silanes with different number of functional groups

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Qi [Key Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Chemistry Discipline, Faculty of Science and Technology, Queensland University of Technology, Brisbane, Queensland 4001 (Australia); He, Hongping, E-mail: hehp@gig.ac.cn [Key Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Chemistry Discipline, Faculty of Science and Technology, Queensland University of Technology, Brisbane, Queensland 4001 (Australia); Li, Tian [Key Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); University of Chinese, Academy of Sciences, Beijing 100039 (China); Frost, Ray L. [Chemistry Discipline, Faculty of Science and Technology, Queensland University of Technology, Brisbane, Queensland 4001 (Australia); Zhang, Dan; He, Zisen [Key Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); University of Chinese, Academy of Sciences, Beijing 100039 (China)

    2014-05-01

    Four silanes, trimethylchlorosilane (TMCS), dimethyldiethoxylsilane (DMDES), 3-aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS), were adopted to graft layered double hydroxides (LDH) via an induced hydrolysis silylation method (IHS). Fourier transform infrared spectra (FTIR) and {sup 29}Si MAS nuclear magnetic resonance spectra ({sup 29}Si MAS NMR) indicated that APTES and TEOS can be grafted onto LDH surfaces via condensation with hydroxyl groups of LDH, while TMCS and DMDES could only be adsorbed on the LDH surface with a small quantity. A combination of X-ray diffraction patterns (XRD) and {sup 29}Si MAS NMR spectra showed that silanes were exclusively present in the external surface and had little influence on the long range order of LDH. The surfactant intercalation experiment indicated that the adsorbed and/or grafted silane could not fix the interlamellar spacing of the LDH. However, they will form crosslink between the particles and affect the further surfactant intercalation in the silylated samples. The replacement of water by ethanol in the tactoids and/or aggregations and the polysiloxane oligomers formed during silylation procedure can dramatically increase the value of BET surface area (S{sub BET}) and total pore volumes (V{sub p}) of the products. - Graphical abstract: The replacement of water by ethanol in the tactoids and aggregations of LDHs, and the polysiloxane oligomers formed during silylation process can dramatically increase the BET surface area (S{sub BET}) and the total pore volume (V{sub p}) of the silylated products. - Highlights: • Silanes with multifunctional groups were grafted onto LDH surface in C{sub 2}H{sub 5}OH medium. • The number of hydrolysable groups in silanes affects the structure of grafted LDH. • Replacement of H{sub 2}O by C{sub 2}H{sub 5}OH in aggregations increases S{sub BET} and V{sub p} of grafted LDH. • Polysiloxane oligomers contribute to the increase of S{sub BET} and V{sub p} of grafted LDH.

  10. Studies on representation of the Lorentz group and gauge theory

    International Nuclear Information System (INIS)

    Hanitriarivo, R.

    2002-01-01

    This work is focused on studies about the representation of the Lorentz group and gauge theory. The mathematical tools required for the different studies are presented, as well as for the representation of the Lorentz group and for the gauge theory. Representation of the Lorentz group gives the possible types of fields and wave functions that describe particles: fermions are described by spinors and bosons are described by scalar or vector. Each of these entities (spinors, scalars, vectors) are characterized by their behavior under the action of Lorentz transformations.Gauge theory is used to describe the interactions between particles. [fr

  11. General-transformation matrix for Dirac spinors and the calculation of spinorial amplitudes

    International Nuclear Information System (INIS)

    Nam, K.; Moravcsik, M.J.

    1983-01-01

    A general transformation matrix T(p's';p,s) is constructed which transforms a Dirac spinor psi(p,s) into another Dirac spinor psi(p',s') with arbitrarily given momenta and polarization states by expoloting the so-called Stech operator as one of generators for those transformations. This transformation matrix is then used in a calculation to yield the spinorial matrix element M = anti psi(p',s')GAMMApsi(p,s) for any spin polarization state. The final expressions of these matrix elements show the explicit structure of spin dependence for the process described by these spinorial amplitudes. The kinematical limiting cases such as very low energy or high energy of the various matrix elements can also be easily displayed. Our method is superior to the existing one in the following points. Since we have a well-defined transformation operator between two Dirac spinor states, we can evaluate the necessary phase factor of the matrix elements in an unambiguous way without introducing the coordinate system. This enables us to write down the Feynman amplitudes of complicated processes in any spin basis very easily in terms of previously calculated matrix elements of anti psiGAMMApsi which are building blocks of those Feynman amplitudes. The usefulness of the results is illustrated on Compton scattering and on the elastic scattering of two identical massive leptons where the phase factor is important. It is also shown that the Stech operator as a polarization operator is simply related to the operator K = #betta#(polarized μ . polarized L + 1)/2 which is often used in bound state problems

  12. Large-scale parallel configuration interaction. II. Two- and four-component double-group general active space implementation with application to BiH

    DEFF Research Database (Denmark)

    Knecht, Stefan; Jensen, Hans Jørgen Aagaard; Fleig, Timo

    2010-01-01

    We present a parallel implementation of a large-scale relativistic double-group configuration interaction CIprogram. It is applicable with a large variety of two- and four-component Hamiltonians. The parallel algorithm is based on a distributed data model in combination with a static load balanci...

  13. Spinors in self-dual Yang-Mills fields in minkowski space

    International Nuclear Information System (INIS)

    Pervushin, V.N.

    1981-01-01

    Yang-Mills theory with infrared divergences removed by spontaneous vacuum symmetry breaking is considered. The corresponding vacuum fields are self-dual and are defined in the Minkowski space. The complete set of solutions of Dirac equations with self-dual fields, depending on certain arbitrary function, is found. Physical observables (charge, energy, spin) for the spinor fields within the self-dual vacuum are calculated and a Hermitean Hamiltonian is obtained. The physical picture corresponds to a relativistic generalization of the hadron bag model [ru

  14. Exact periodic and solitonic states of the spinor condensates in a uniform external potential

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhi-Hai [School of Physics and Electronics, Yancheng Teachers University, Yancheng 224051 (China); Yang, Shi-Jie, E-mail: yangshijie@tsinghua.org.cn [Department of Physics, Beijing Normal University, Beijing 100875 (China)

    2016-08-15

    We propose a method to analytically solve the one-dimensional coupled nonlinear Gross–Pitaevskii equations which govern the motion of the spinor Bose–Einstein condensates. In a uniform external potential, several classes of exact periodic and solitonic solutions, either in real or in complex forms, are obtained for both the F=1 and F=2 condensates for the Hamiltonian comprising the kinetic energy, the linear and the quadratic Zeeman energies. Real solutions take the form of composite soliton trains. Complex solutions correspond to the mass counter-flows as well as spin currents. These solutions are general that contains neither approximations nor constraints on the system parameters.

  15. A massive spinless particle and the unit of length in a spinor geometry

    International Nuclear Information System (INIS)

    Lynch, J.T.

    1999-01-01

    The field equations of a spinor geometry are solved for a massive spinless particle. The particle has a composite internal structure, a quantised rest-mass, and a positive-definite and everywhere finite mass density. The particle is stable in isolation, but evidently unstable in the presence of fields due to external sources, such as the electromagnetic fields of particle detectors. On identifying the particle as a neutral meson, the unit of length of the geometry turns out to be approximately 10 -15 m

  16. Numerical simulation of spin motion in circular accelerators using spinor formulation

    International Nuclear Information System (INIS)

    Nghiem, P.; Tkatchenko, A.

    1992-07-01

    A simple method is presented based on spinor algebra formalism for tracking the spin motion in circular accelerators. Using an analytical expression of the one-turn transformation matrix including the effects of perturbating fields or of siberian snakes, a simple and very fast numerical code has been written for studying spin motion in various circumstances. In particular, effects of synchrotron oscillations on final polarization after one isolated resonance crossing are simulated. Results of these calculations agree very well with those which have been obtained previously from analytical approaches or from other numerical-simulation programs. (author) 8 refs.; 14 figs

  17. Some statistical aspects of the spinor field Fermi-Bose duality

    Directory of Open Access Journals (Sweden)

    V.M. Simulik

    2012-12-01

    Full Text Available The structure of 29-dimensional extended real Clifford-Dirac algebra, which has been introduced in our paper Phys. Lett. A, 2011, Vol. 375, 2479, is considered in brief. Using this algebra, the property of Fermi-Bose duality of the Dirac equation with nonzero mass is proved. It means that Dirac equation can describe not only the fermionic but also the bosonic states. The proof of our assertion based on the examples of bosonic symmetries, solutions and conservation laws is given. Some statistical aspects of the spinor field Fermi-Bose duality are discussed.

  18. Spatial Landau-Zener-Stueckelberg interference in spinor Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Zhang, J.-N.; Sun, C.-P.; Yi, S.; Nori, Franco

    2011-01-01

    We investigate the Stueckelberg oscillations of a spin-1 Bose-Einstein condensate subject to a spatially inhomogeneous transverse magnetic field and a periodic longitudinal field. We show that the time-domain Stueckelberg oscillations result in modulations in the density profiles of all spin components due to the spatial inhomogeneity of the transverse field. This phenomenon represents the Landau-Zener-Stueckelberg interference in the space domain. Since the magnetic dipole-dipole interaction between spin-1 atoms induces an inhomogeneous effective magnetic field, interference fringes also appear if a dipolar spinor condensate is driven periodically. We also point out some potential applications of this spatial Landau-Zener-Stuekelberg interference.

  19. Spinor Field Realizations of the half-integer $W_{2,s}$ Strings

    OpenAIRE

    Wei, Shao-Wen; Liu, Yu-Xiao; Zhang, Li-Jie; Ren, Ji-Rong

    2008-01-01

    The grading Becchi-Rouet-Stora-Tyutin (BRST) method gives a way to construct the integer $W_{2,s}$ strings, where the BRST charge is written as $Q_B=Q_0+Q_1$. Using this method, we reconstruct the nilpotent BRST charges $Q_{0}$ for the integer $W_{2,s}$ strings and the half-integer $W_{2,s}$ strings. Then we construct the exact grading BRST charge with spinor fields and give the new realizations of the half-integer $W_{2,s}$ strings for the cases of $s=3/2$, 5/2, and 7/2.

  20. Killing spinor equations in dimension 7 and geometry of integrable G2-manifolds

    International Nuclear Information System (INIS)

    Friedrich, Thomas; Ivanov, Stefan

    2001-12-01

    We compute the scalar curvature of 7-dimensional G 2 -manifolds admitting a connection with totally skew-symmetric torsion. We prove the formula for the general solution of the Killing spinor equation and express the Riemannian scalar curvature of the solution in terms of the dilation function and the NS 3-form field. In dimension n=7 the dilation function involved in the second fermionic string equation has an interpretation as a conformal change of the underlying integrable G 2 -structure into a cocalibrated one of pure type W 3 . (author)

  1. Equivalence of the spinning superparticle descriptions with Grassmann variables or with c-number spinors

    International Nuclear Information System (INIS)

    Barut, A.O.; Pavsic, M.

    1988-05-01

    A remarkable equivalence is established between the theories of spinning particles or superparticles using anticommuting Grassmann variables on the one hand and commuting c-number spinors on the other. We consider both real and complex Grassmann variables and map the equations of motion and the supersymmetry transformation from one theory to another. The more intuitive c-number theory allows us to generalize the notion of Zitterbewegung to strings and membranes. (A hidden supersymmetry exists in the classical model of the Dirac electron.) (author). 12 refs

  2. On the problem of unboundedness from below of the spinor QED Hamiltonian

    International Nuclear Information System (INIS)

    Zastavenko, L.G.

    1993-01-01

    It is show that the Hamiltonian H QED + H 2 , where H QED is the spinor QED Hamiltonian and H 2 is the positive transversal photon mass term, is unbounded from below if the electromagnetic coupling constant e 2 is small enough, e 2 0 2 , and the transversal photon squared mass parameter M 2 is not large: 0 2 2 (1 - e 2 /e 0 2 )l 2 , here, l is the cut-off parameter; and c and e 0 2 , positive constants which do not depend on any parameters. 7 refs

  3. Exploratory double-blind, parallel-group, placebo-controlled extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis.

    Science.gov (United States)

    2017-10-01

    Following the first phase III study of edaravone for amyotrophic lateral sclerosis (ALS), this extension study was performed to evaluate longer-term efficacy and safety. Patients given edaravone in the first 24-week phase III study (Cycles 1-6) were randomised to edaravone (E-E) or placebo (E-P) in the subsequent 24-week double-blind period (Cycles 7-12). Patients given placebo in phase III were switched to edaravone (P-E). Subsequently, all patients received edaravone for 12 weeks (Cycles 13-15). Efficacy endpoints included revised ALS Functional Rating Scale (ALSFRS-R) score. Analysis populations were the full analysis set (FAS) and the efficacy-expected subpopulation (EESP) defined by post-hoc analysis of the first phase III study. The least-squares mean and standard error of the intergroup difference (E-E vs. E-P) of change in the ALSFRS-R score from Cycles 7-12 was 1.16 ± 0.93 (p = 0.2176) in the FAS, and 1.85 ± 1.14 (p = 0.1127) in the EESP. The ALSFRS-R score changed almost linearly in the E-E group throughout Cycles 1-15 (60 weeks). The incidence of serious adverse events associated with ALS progression was higher in E-E than in E-P. Edaravone might have potential efficacy for up to 15 cycles when used to treat patients in the EESP with careful safety monitoring.

  4. Determination and analysis of site-specific 125I decay-induced DNA double-strand break end-group structures.

    Science.gov (United States)

    Datta, Kamal; Weinfeld, Michael; Neumann, Ronald D; Winters, Thomas A

    2007-02-01

    End groups contribute to the structural complexity of radiation-induced DNA double-strand breaks (DSBs). As such, end-group structures may affect a cell's ability to repair DSBs. The 3'-end groups of strand breaks caused by gamma radiation, or oxidative processes, under oxygenated aqueous conditions have been shown to be distributed primarily between 3'-phosphoglycolate and 3'-phosphate, with 5'-phosphate ends in both cases. In this study, end groups of the high-LET-like DSBs caused by 125I decay were investigated. Site-specific DNA double-strand breaks were produced in plasmid pTC27 in the presence or absence of 2 M DMSO by 125I-labeled triplex-forming oligonucleotide targeting. End-group structure was assessed enzymatically as a function of the DSB end to serve as a substrate for ligation and various forms of end labeling. Using this approach, we have demonstrated 3'-hydroxyl (3'-OH) and 3'-phosphate (3'-P) end groups and 5'-ends (> or = 42%) terminated by phosphate. A 32P postlabeling assay failed to detect 3'-phosphoglycolate in a restriction fragment terminated by the 125I-induced DNA double-strand break, and this is likely due to restricted oxygen diffusion during irradiation as a frozen aqueous solution. Even so, end-group structure and relative distribution varied as a function of the free radical scavenging capacity of the irradiation buffer.

  5. Quantum gravity in three dimensions, Witten spinors and the quantisation of length

    Science.gov (United States)

    Wieland, Wolfgang

    2018-05-01

    In this paper, I investigate the quantisation of length in euclidean quantum gravity in three dimensions. The starting point is the classical hamiltonian formalism in a cylinder of finite radius. At this finite boundary, a counter term is introduced that couples the gravitational field in the interior to a two-dimensional conformal field theory for an SU (2) boundary spinor, whose norm determines the conformal factor between the fiducial boundary metric and the physical metric in the bulk. The equations of motion for this boundary spinor are derived from the boundary action and turn out to be the two-dimensional analogue of the Witten equations appearing in Witten's proof of the positive mass theorem. The paper concludes with some comments on the resulting quantum theory. It is shown, in particular, that the length of a one-dimensional cross section of the boundary turns into a number operator on the Fock space of the theory. The spectrum of this operator is discrete and matches the results from loop quantum gravity in the spin network representation.

  6. Phase-space spinor amplitudes for spin-1/2 systems

    International Nuclear Information System (INIS)

    Watson, P.; Bracken, A. J.

    2011-01-01

    The concept of phase-space amplitudes for systems with continuous degrees of freedom is generalized to finite-dimensional spin systems. Complex amplitudes are obtained on both a sphere and a finite lattice, in each case enabling a more fundamental description of pure spin states than that previously given by Wigner functions. In each case the Wigner function can be expressed as the star product of the amplitude and its conjugate, so providing a generalized Born interpretation of amplitudes that emphasizes their more fundamental status. The ordinary product of the amplitude and its conjugate produces a (generalized) spin Husimi function. The case of spin-(1/2) is treated in detail, and it is shown that phase-space amplitudes on the sphere transform correctly as spinors under rotations, despite their expression in terms of spherical harmonics. Spin amplitudes on a lattice are also found to transform as spinors. Applications are given to the phase space description of state superposition, and to the evolution in phase space of the state of a spin-(1/2) magnetic dipole in a time-dependent magnetic field.

  7. DDF construction and D-brane boundary states in pure spinor formalism

    International Nuclear Information System (INIS)

    Mukhopadhyay, Partha

    2006-01-01

    Open string boundary conditions for non-BPS D-branes in type II string theories discussed in hep-th/0505157 give rise to two sectors with integer (R sector) and half-integer (NS sector) modes for the combined fermionic matter and bosonic ghost variables in pure spinor formalism. Exploiting the manifest supersymmetry of the formalism we explicitly construct the DDF (Del Giudice, Di Vecchia, Fubini) states in both the sectors which are in one-to-one correspondence with the states in light-cone Green-Schwarz formalism. We also give a proof of validity of this construction. A similar construction in the closed string sector enables us to define a physical Hilbert space in pure spinor formalism which is used to project the covariant boundary states of both the BPS and non-BPS instantonic D-branes. These projected boundary states take exactly the same form as those found in light-cone Green-Schwarz formalism and are suitable for computing the cylinder diagram with manifest open-closed duality

  8. Approximate KMS states for scalar and spinor fields in Friedmann-Robertson-Walker spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Dappiaggi, Claudio; Hack, Thomas-Paul [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Pinamonti, Nicola [Roma ' ' Tor Vergata' ' Univ. (Italy). Dipt. di Matematica

    2010-09-15

    We construct and discuss Hadamard states for both scalar and Dirac spinor fields in a large class of spatially flat Friedmann-Robertson-Walker spacetimes characterised by an initial phase either of exponential or of power-law expansion. The states we obtain can be interpreted as being in thermal equilibrium at the time when the scale factor a has a specific value a = a{sub 0}. In the case a{sub 0} = 0, these states fulfil a strict KMS condition on the boundary of the spacetime, which is either a cosmological horizon, or a Big Bang hypersurface. Furthermore, in the conformally invariant case, they are conformal KMS states on the full spacetime. However, they provide a natural notion of an approximate KMS state also in the remaining cases, especially for massive fields. On the technical side, our results are based on a bulk-to-boundary reconstruction technique already successfully applied in the scalar case and here proven to be suitable also for spinor fields. The potential applications of the states we find range over a broad spectrum, but they appear to be suited to discuss in particular thermal phenomena such as the cosmic neutrino background or the quantum state of dark matter. (orig.)

  9. Approximate KMS states for scalar and spinor fields in Friedmann-Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Dappiaggi, Claudio; Hack, Thomas-Paul; Pinamonti, Nicola

    2010-09-01

    We construct and discuss Hadamard states for both scalar and Dirac spinor fields in a large class of spatially flat Friedmann-Robertson-Walker spacetimes characterised by an initial phase either of exponential or of power-law expansion. The states we obtain can be interpreted as being in thermal equilibrium at the time when the scale factor a has a specific value a = a 0 . In the case a 0 = 0, these states fulfil a strict KMS condition on the boundary of the spacetime, which is either a cosmological horizon, or a Big Bang hypersurface. Furthermore, in the conformally invariant case, they are conformal KMS states on the full spacetime. However, they provide a natural notion of an approximate KMS state also in the remaining cases, especially for massive fields. On the technical side, our results are based on a bulk-to-boundary reconstruction technique already successfully applied in the scalar case and here proven to be suitable also for spinor fields. The potential applications of the states we find range over a broad spectrum, but they appear to be suited to discuss in particular thermal phenomena such as the cosmic neutrino background or the quantum state of dark matter. (orig.)

  10. Dirac bi-spinor entanglement under local noise and its simulation by Jaynes-Cummings interactions

    Science.gov (United States)

    Bittencourt, Victor A. S. V.; Bernardini, Alex E.

    2017-08-01

    A description of the effects of the local noise on the quantum entanglement constraining the internal degrees of freedom of Dirac bi-spinor structures driven by arbitrary Poincaré invariant potentials is proposed. Given that the Dirac equation dynamics including external potentials can be simulated by a suitable four level trapped ion setup, quantum entanglement of two-qubit ionic states with quantum numbers related to the total angular momentum and to its projection onto the direction of the external magnetic field (used for lift the ions degeneracy), are recovered by means of a suitable ansatz. This formalism allows the inclusion of noise effects, which leads to disentanglement in the four level trapped ion quantum system. Our results indicate the role of interactions in bi-spinor entanglement, as well as the description of disentanglement in ionic states under local noises. For a state prepared initially in one of the ionic levels, local noise induces entanglement sudden death followed by sudden revivals driven by the noiseless dynamics of the state. Residual quantum correlations are observed in the intervals where such state is separable. Schrödinger cat and Werner states partially loose their initial entanglement content due to the interaction with the noisy environment but presenting entanglement oscillations without sudden death. Because Dirac equation describes low energy excitations of mono layer and bi-layer graphene, the formalism can also be applied to compute, for instance, electron-hole or electron/electron entanglement in various circumstances.

  11. Nature of the Schwinger term in spinor electrodynamics. [Dispersion formulation,dimensions,green functions,c-number,linear unitarity condition

    Energy Technology Data Exchange (ETDEWEB)

    Nishijima, K; Sasaki, R [Tokyo Univ. (Japan). Dept. of Physics

    1975-06-01

    On the basis of the dispersion formulation of field theories the Schwinger term in spinor electrodynamics is shown to be a c-number. The essence of the proof consists in the dimensional argument and the characteristic features of the linear unitarity condition for a set of Green's functions involving the Schwinger term.

  12. Master symmetry in the AdS{sub 5}×S{sup 5} pure spinor string

    Energy Technology Data Exchange (ETDEWEB)

    Chandía, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales & Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); III, William Divine Linch [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy,Texas A& M University,College Station, TX 77843-4242 (United States); Vallilo, Brenno Carlini [Departamento de Ciencias Físicas, Universidad Andres Bello,Sazie 2212, Santiago (Chile)

    2017-01-09

    We lift the set of classical non-local symmetries recently studied by Klose, Loebbert, and Münkler in the context of ℤ{sub 2} cosets to the pure spinor description of the superstring in the AdS{sub 5}×S{sup 5} background.

  13. Solutions of the Yang-Baxter equation: Descendants of the six-vertex model from the Drinfeld doubles of dihedral group algebras

    International Nuclear Information System (INIS)

    Finch, P.E.; Dancer, K.A.; Isaac, P.S.; Links, J.

    2011-01-01

    The representation theory of the Drinfeld doubles of dihedral groups is used to solve the Yang-Baxter equation. Use of the two-dimensional representations recovers the six-vertex model solution. Solutions in arbitrary dimensions, which are viewed as descendants of the six-vertex model case, are then obtained using tensor product graph methods which were originally formulated for quantum algebras. Connections with the Fateev-Zamolodchikov model are discussed.

  14. The efficacy of Femal in women with premenstrual syndrome: a randomised, double-blind, parallel-group, placebo-controlled, multicentre study

    DEFF Research Database (Denmark)

    Gerhardsen, G.; Hansen, A.V.; Killi, M.

    2008-01-01

    Introduction: A double-blind, placebo-controlled, randomised, parallel-group, multicentre study was conducted to evaluate the effect of a pollen-based herbal medicinal product, Femal (R) (Sea-Band Ltd, Leicestershire, UK), on premenstrual sleep disturbances (PSD) in women with premenstrual syndrome...... as the main symptom cluster makes this herbal medicinal product a promising addition to the therapeutic arsenal for women with PMS Udgivelsesdato: 2008/6...

  15. Nests of red wood ants (Formica rufa-group) are positively associated with tectonic faults: a double-blind test.

    Science.gov (United States)

    Del Toro, Israel; Berberich, Gabriele M; Ribbons, Relena R; Berberich, Martin B; Sanders, Nathan J; Ellison, Aaron M

    2017-01-01

    Ecological studies often are subjected to unintentional biases, suggesting that improved research designs for hypothesis testing should be used. Double-blind ecological studies are rare but necessary to minimize sampling biases and omission errors, and improve the reliability of research. We used a double-blind design to evaluate associations between nests of red wood ants ( Formica rufa , RWA) and the distribution of tectonic faults. We randomly sampled two regions in western Denmark to map the spatial distribution of RWA nests. We then calculated nest proximity to the nearest active tectonic faults. Red wood ant nests were eight times more likely to be found within 60 m of known tectonic faults than were random points in the same region but without nests. This pattern paralleled the directionality of the fault system, with NNE-SSW faults having the strongest associations with RWA nests. The nest locations were collected without knowledge of the spatial distribution of active faults thus we are confident that the results are neither biased nor artefactual. This example highlights the benefits of double-blind designs in reducing sampling biases, testing controversial hypotheses, and increasing the reliability of the conclusions of research.

  16. Route to non-Abelian quantum turbulence in spinor Bose-Einstein condensates

    Science.gov (United States)

    Mawson, Thomas; Ruben, Gary; Simula, Tapio

    2015-06-01

    We have studied computationally the collision dynamics of spin-2 Bose-Einstein condensates initially confined in a triple-well trap. Depending on the phase structure of the initial-state spinor wave function, the collision of the three condensate fragments produces one of many possible vortex-antivortex lattices, after which the system transitions to quantum turbulence. We find that the emerging vortex lattice structures can be described in terms of multiwave interference. We show that the three-fragment collisions can be used to systematically produce staggered vortex-antivortex honeycomb lattices of fractional-charge vortices, whose collision dynamics are known to be non-Abelian. Such condensate collider experiments could potentially be used as a controllable pathway to generating non-Abelian superfluid turbulence with networks of vortex rungs.

  17. Exact spinor-scalar bound states in a quantum field theory with scalar interactions

    International Nuclear Information System (INIS)

    Shpytko, Volodymyr; Darewych, Jurij

    2001-01-01

    We study two-particle systems in a model quantum field theory in which scalar particles and spinor particles interact via a mediating scalar field. The Lagrangian of the model is reformulated by using covariant Green's functions to solve for the mediating field in terms of the particle fields. This results in a Hamiltonian in which the mediating-field propagator appears directly in the interaction term. It is shown that exact two-particle eigenstates of the Hamiltonian can be determined. The resulting relativistic fermion-boson equation is shown to have Dirac and Klein-Gordon one-particle limits. Analytical solutions for the bound state energy spectrum are obtained for the case of massless mediating fields

  18. Photon transitions between baryons in a new hadron scheme. [Composite model, Dirac spinor

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, H [Kanazawa Inst. of Tech. (Japan); Toya, M

    1976-05-01

    Photon transitions from the ground state baryon to the nonstrange excited one with L=0, 1 and 2 are investigated. The discussion is based on a new scheme of hadron composite model which takes account of the lower component of the Dirac spinor of constituent particles even in a hadron rest system. There appear generally four independent model amplitudes. Each process ..gamma..+p..-->..B/sub 8/* is described in terms of an individual model amplitude. This helps us to explain the characteristic features of experiment and solve the troubles found in the nonrelativistic scheme. Both magnitudes and signs of predicted amplitudes are shown to be in good agreement with experimental data. From this comparison the specific features of the model amplitudes are found. Discussion is made for higher excited baryons.

  19. Synthetic Landau Levels and Spinor Vortex Matter on a Haldane Spherical Surface with a Magnetic Monopole.

    Science.gov (United States)

    Zhou, Xiang-Fa; Wu, Congjun; Guo, Guang-Can; Wang, Ruquan; Pu, Han; Zhou, Zheng-Wei

    2018-03-30

    We present a flexible scheme to realize exact flat Landau levels on curved spherical geometry in a system of spinful cold atoms. This is achieved by applying the Floquet engineering of a magnetic quadrupole field to create a synthetic monopole field in real space. The system can be exactly mapped to the electron-monopole system on a sphere, thus realizing Haldane's spherical geometry for fractional quantum Hall physics. This method works for either bosons or fermions. We investigate the ground-state vortex pattern for an s-wave interacting atomic condensate by mapping this system to the classical Thompson's problem. The distortion and stability of the vortex pattern are further studied in the presence of dipolar interaction. Our scheme is compatible with the current experimental setup, and may serve as a promising route of investigating quantum Hall physics and exotic spinor vortex matter on curved space.

  20. Spinor matter fields in SL(2,C) gauge theories of gravity: Lagrangian and Hamiltonian approaches

    Science.gov (United States)

    Antonowicz, Marek; Szczyrba, Wiktor

    1985-06-01

    We consider the SL(2,C)-covariant Lagrangian formulation of gravitational theories with the presence of spinor matter fields. The invariance properties of such theories give rise to the conservation laws (the contracted Bianchi identities) having in the presence of matter fields a more complicated form than those known in the literature previously. A general SL(2,C) gauge theory of gravity is cast into an SL(2,C)-covariant Hamiltonian formulation. Breaking the SL(2,C) symmetry of the system to the SU(2) symmetry, by introducing a spacelike slicing of spacetime, we get an SU(2)-covariant Hamiltonian picture. The qualitative analysis of SL(2,C) gauge theories of gravity in the SU(2)-covariant formulation enables us to define the dynamical symplectic variables and the gauge variables of the theory under consideration as well as to divide the set of field equations into the dynamical equations and the constraints. In the SU(2)-covariant Hamiltonian formulation the primary constraints, which are generic for first-order matter Lagrangians (Dirac, Weyl, Fierz-Pauli), can be reduced. The effective matter symplectic variables are given by SU(2)-spinor-valued half-forms on three-dimensional slices of spacetime. The coupled Einstein-Cartan-Dirac (Weyl, Fierz-Pauli) system is analyzed from the (3+1) point of view. This analysis is complete; the field equations of the Einstein-Cartan-Dirac theory split into 18 gravitational dynamical equations, 8 dynamical Dirac equations, and 7 first-class constraints. The system has 4+8=12 independent degrees of freedom in the phase space.

  1. Spinor matter fields in SL(2,C) gauge theories of gravity: Lagrangian and Hamiltonian approaches

    International Nuclear Information System (INIS)

    Antonowicz, M.; Szczyrba, W.

    1985-01-01

    We consider the SL(2,C)-covariant Lagrangian formulation of gravitational theories with the presence of spinor matter fields. The invariance properties of such theories give rise to the conservation laws (the contracted Bianchi identities) having in the presence of matter fields a more complicated form than those known in the literature previously. A general SL(2,C) gauge theory of gravity is cast into an SL(2,C)-covariant Hamiltonian formulation. Breaking the SL(2,C) symmetry of the system to the SU(2) symmetry, by introducing a spacelike slicing of spacetime, we get an SU(2)-covariant Hamiltonian picture. The qualitative analysis of SL(2,C) gauge theories of gravity in the SU(2)-covariant formulation enables us to define the dynamical symplectic variables and the gauge variables of the theory under consideration as well as to divide the set of field equations into the dynamical equations and the constraints. In the SU(2)-covariant Hamiltonian formulation the primary constraints, which are generic for first-order matter Lagrangians (Dirac, Weyl, Fierz-Pauli), can be reduced. The effective matter symplectic variables are given by SU(2)-spinor-valued half-forms on three-dimensional slices of spacetime. The coupled Einstein-Cartan-Dirac (Weyl, Fierz-Pauli) system is analyzed from the (3+1) point of view. This analysis is complete; the field equations of the Einstein-Cartan-Dirac theory split into 18 gravitational dynamical equations, 8 dynamical Dirac equations, and 7 first-class constraints. The system has 4+8 = 12 independent degrees of freedom in the phase space

  2. Feasibility study on energy conservation through modernization of cement plant (Sichuan Double Horse Cement Group Co. Ltd.)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    An investigational study was conducted of possibilities of energy conservation and greenhouse effect gas emission reduction in the cement production process of Double Horse Cement Co., Mianyang City, Sichuan Province, China. Double Horse Cement adopts the wet type long kiln production system and has a production ability of approximately 1.5 million t/y. In the project, as to three production lines out of the six production lines, improvement was planned to be made of the technologies on the following: mixing of raw materials, grinding of raw materials, NSP, clinker cooler, clinker pre-grinder, high-efficiency separator, waste heat use power generation, etc. As a result of the study, it was found that the energy conservation amount obtained was 54,646 toe/y. And, the amount of greenhouse effect gas reduction was 169,086 t-CO2/y. The total fund required for this project was approximately 5.553 billion yen and the internal earning rate was 7.36% after tax. When the project is carried out, expenses vs. effects are 9.8 toe/million yen in energy conservation amount and 30.4 t-CO2/million yen in greenhouse effect gas reduction. (NEDO)

  3. Matter rogue waves for the three-component Gross-Pitaevskii equations in the spinor Bose-Einstein condensates.

    Science.gov (United States)

    Sun, Wen-Rong; Wang, Lei

    2018-01-01

    To show the existence and properties of matter rogue waves in an F =1 spinor Bose-Einstein condensate (BEC), we work on the three-component Gross-Pitaevskii (GP) equations. Via the Darboux-dressing transformation, we obtain a family of rational solutions describing the extreme events, i.e. rogue waves. This family of solutions includes bright-dark-bright and bright-bright-bright rogue waves. The algebraic construction depends on Lax matrices and their Jordan form. The conditions for the existence of rogue wave solutions in an F =1 spinor BEC are discussed. For the three-component GP equations, if there is modulation instability, it is of baseband type only, confirming our analytic conditions. The energy transfers between the waves are discussed.

  4. On semiclassical analysis of pure spinor superstring in an AdS{sub 5} x S{sup 5} background

    Energy Technology Data Exchange (ETDEWEB)

    Aisaka, Yuri [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Sao Paulo State Univ. (Brazil). Inst. de Fisica Teorica; Ibiapina Bevilaqua, L. [Univ. Federal do Rio Grande do Norte, Natal (Brazil). Esola de Ciencias e Tecnologia; Vallilo, Brenno C. [Santiago Univ. (Chile). Dept. de Ciencias Fisicas

    2012-06-15

    Relation between semiclassical analyses of Green-Schwarz and pure spinor formalisms in an AdS{sub 5} x S{sup 5} background is clarified. It is shown that the two formalisms have identical semiclassical partition functions for a simple family of classical solutions. It is also shown that, when the classical string is furthermore rigid, this in turn implies that the two formalisms predict the same one-loop corrections to spacetime energies.

  5. Localized nonlinear waves and dynamical stability in spinor Bose–Einstein condensates with time–space modulation

    Science.gov (United States)

    Yao, Yu-Qin; Han, Wei; Li, Ji; Liu, Wu-Ming

    2018-05-01

    Nonlinearity is one of the most remarkable characteristics of Bose–Einstein condensates (BECs). Much work has been done on one- and two-component BECs with time- or space-modulated nonlinearities, while there is little work on spinor BECs with space–time-modulated nonlinearities. In the present paper we investigate localized nonlinear waves and dynamical stability in spinor Bose–Einstein condensates with nonlinearities dependent on time and space. We solve the three coupled Gross–Pitaevskii equations by similarity transformation and obtain two families of exact matter wave solutions in terms of Jacobi elliptic functions and the Mathieu equation. The localized states of the spinor matter wave describe the dynamics of vector breathing solitons, moving breathing solitons, quasi-breathing solitons and resonant solitons. The results show that one-order vector breathing solitons, quasi-breathing solitons, resonant solitons and the moving breathing solitons ψ ±1 are all stable, but the moving breathing soliton ψ 0 is unstable. We also present the experimental parameters to realize these phenomena in future experiments.

  6. Evaluation of mitigation strategies in Facility Group 1 double-shell flammable-gas tanks at the Hanford Site

    International Nuclear Information System (INIS)

    Unal, C.; Sadasivan, P.; Kubic, W.L.; White, J.R.

    1997-11-01

    Radioactive nuclear waste at the Hanford Site is stored in underground waste storage tanks at the site. The tanks fall into two main categories: single-shell tanks (SSTs) and double-shell tanks (DSTs). There are a total of 149 SSTs and 28 DSTs. The wastes stored in the tanks are chemically complex. They basically involve various sodium salts (mainly nitrite, nitrate, carbonates, aluminates, and hydroxides), organic compounds, heavy metals, and various radionuclides, including cesium, strontium, plutonium, and uranium. The waste is known to generate flammable gas (FG) [hydrogen, ammonia, nitrous oxide, hydrocarbons] by complex chemical reactions. The process of gas generation, retention, and release is transient. Some tanks reach a quasi-steady stage where gas generation is balanced by the release rate. Other tanks show continuous cycles of retention followed by episodic release. There currently are 25 tanks on the Flammable Gas Watch List (FGWL). The objective of this report is to evaluate possible mitigation strategies to eliminate the FG hazard. The evaluation is an engineering study of mitigation concepts for FG generation, retention, and release behavior in Tanks SY-101, AN-103, AN 104, An-105, and Aw-101. Where possible, limited quantification of the effects of mitigation strategies on the FG hazard also is considered. The results obtained from quantification efforts discussed in this report should be considered as best-estimate values. Results and conclusions of this work are intended to help in establishing methodologies in the contractor's controls selection analysis to develop necessary safety controls for closing the FG unreviewed safety question. The general performance requirements of any mitigation scheme are discussed first

  7. The Effectiveness of Group Cognitive Behavioral Therapy in Treating Obsessive-Compulsive Disorder in Women with Multiple Sclerosis (MS): A randomized double-blind controlled trial.

    Science.gov (United States)

    Sayyah, Mehdi; Bagheri, Parisa; Karimi, Negar; Ghasemzadeh, Azizreza

    2016-04-01

    Obsessive-compulsive disorder (OCD) is one of the most prevalent psychiatric disorders and can cause problems for individuals in all aspects of life, including social and personal dimensions. To study the effect of group cognitive-behavioral therapy on the reduction of OCD symptoms in female participants with multiple sclerosis (MS). This double-blind randomized control trial was conducted from May 2012 to December 2014. The participants included 75 patients with MS who suffered from OCD and were referred to the Loghman Hakim and Imam Khomeini hospitals in Tehran, Iran. Thirty participants had been diagnosed through Yale-Brown Obsessive-Compulsive Symptoms (Y-BOCS). The participants were randomly divided into an experimental group (n=15) and a control group (n=15). Eleven sessions of cognitive-behavioral therapy were provided for the experimental group. Patients in the control group continued with their normal living. Hypotheses were tested using an analysis of covariance (ANCOVA). A significant reduction was found in the experimental group's obsessive-compulsive symptoms after cognitive-behavioral therapy (pcognitive-behavioral therapy could considerably reduce OCD symptoms in women with MS. The application of this method by therapists, especially Iranian clinicians, is recommended.

  8. Superradiant MeV γ Scattered by a Room-Temperature Spinor Quantum Fluid

    Directory of Open Access Journals (Sweden)

    Yao Cheng

    2017-07-01

    Full Text Available Recent reports have revealed the rich long-lived Mossbauer phenomenon of 93mNb, in which it has long been speculated that the delocalized 93mNb undergoes Bose-Einstein condensation following an increase in the 93mNb density beyond the threshold of 1012 cm−3 at room temperature. We now report on the superradiant Rayleigh of the M4 γ at 662 keV scattered into end-fire modes along the long axis of the sample, as evidence of Bose-Einstein condensation. We observed the Arago (Poisson’s spot in order to demonstrate a near-field γ-ray diffraction from a mm-sized γ source, as well as a γ interference beyond the Huygens-Fresnel principle. During the 107-day monitoring period, seven Sisyphus cycles of mode hopping appeared in the superradiance, which demonstrates the optomechanic bistabilty provided by the collective interaction between the spinor quantum fluid and the impinging γs. Condensate-light interaction produces a pm matter-wave grating to become a Fabry-Pérot resonator with a Q-factor on the order of 1020, from which end-fired γs lase.

  9. Bell Inequality, Einstein-Podolsky-Rosen Steering, and Quantum Metrology with Spinor Bose-Einstein Condensates

    Science.gov (United States)

    Wasak, Tomasz; Chwedeńczuk, Jan

    2018-04-01

    We propose an experiment, where the Bell inequality is violated in a many-body system of massive particles. The source of correlated atoms is a spinor F =1 Bose-Einstein condensate residing in an optical lattice. We characterize the complete procedure—the local operations, the measurements, and the inequality—necessary to run the Bell test. We show how the degree of violation of the Bell inequality depends on the strengths of the two-body correlations and on the number of scattered pairs. We show that the system can be used to demonstrate the Einstein-Podolsky-Rosen paradox. Also, the scattered pairs are an excellent many-body resource for the quantum-enhanced metrology. Our results apply to any multimode system where the spin-changing collision drives the scattering into separate regions. The presented inquiry shows that such a system is versatile as it can be used for the tests of nonlocality, quantum metrology, and quantum information.

  10. Quantum fluctuations and gapped Goldstone modes in spinor Bose-Einstein condensates

    Science.gov (United States)

    Beekman, Aron

    2015-03-01

    The classical Heisenberg ferromagnet is an exact eigenstate of the quantum Hamiltonian and therefore has no quantum fluctuations. Furthermore it has a reduced number of Goldstone modes, an order parameter that is itself a symmetry generator, is a highest-weight state for the spin algebra, and has no tower of states of vanishing energy. We derive the connection between all these properties and provide general criteria for their presence in other spontaneously-broken symmetry states. The phletora of groundstates in spinor Bose-Einstein condensates is an ideal testing ground for these predictions. In particular the phases with non-maximal polarization (e.g. the F-phase in spin-3 condensates) have an additional gapped mode that is a partner to the quadratically dispersing Goldstone mode, as compared to the maximally polarized, ferromagnetic phase. Furthermore there is a fundamental limit to the coherence time of superpositions in the non-maximally polarized state, which should manifest itself for small-size systems.

  11. Vortex and half-vortex dynamics in a nonlinear spinor quantum fluid.

    Science.gov (United States)

    Dominici, Lorenzo; Dagvadorj, Galbadrakh; Fellows, Jonathan M; Ballarini, Dario; De Giorgi, Milena; Marchetti, Francesca M; Piccirillo, Bruno; Marrucci, Lorenzo; Bramati, Alberto; Gigli, Giuseppe; Szymańska, Marzena H; Sanvitto, Daniele

    2015-12-01

    Vortices are archetypal objects that recur in the universe across the scale of complexity, from subatomic particles to galaxies and black holes. Their appearance is connected with spontaneous symmetry breaking and phase transitions. In Bose-Einstein condensates and superfluids, vortices are both point-like and quantized quasiparticles. We use a two-dimensional (2D) fluid of polaritons, bosonic particles constituted by hybrid photonic and electronic oscillations, to study quantum vortex dynamics. Polaritons benefit from easiness of wave function phase detection, a spinor nature sustaining half-integer vorticity, strong nonlinearity, and tuning of the background disorder. We can directly generate by resonant pulsed excitations a polariton condensate carrying either a full or half-integer vortex as initial condition and follow their coherent evolution using ultrafast imaging on the picosecond scale. The observations highlight a rich phenomenology, such as the spiraling of the half-vortex and the joint path of the twin charges of a full vortex, until the moment of their splitting. Furthermore, we observe the ordered branching into newly generated secondary couples, associated with the breaking of radial and azimuthal symmetries. This allows us to devise the interplay of nonlinearity and sample disorder in shaping the fluid and driving the vortex dynamics. In addition, our observations suggest that phase singularities may be seen as fundamental particles whose quantized events span from pair creation and recombination to 2D+t topological vortex strings.

  12. Magneto-optical quantum interferences in a system of spinor excitons

    Science.gov (United States)

    Kuan, Wen-Hsuan; Gudmundsson, Vidar

    2018-04-01

    In this work we investigate magneto-optical properties of two-dimensional semiconductor quantum-ring excitons with Rashba and Dresselhaus spin-orbit interactions threaded by a magnetic flux perpendicular to the plane of the ring. By calculating the excitonic Aharonov-Bohm spectrum, we study the Coulomb and spin-orbit effects on the Aharonov-Bohm features. From the light-matter interactions of the excitons, we find that for scalar excitons, there are open channels for spontaneous recombination resulting in a bright photoluminescence spectrum, whereas the forbidden recombination of dipolar excitons results in a dark photoluminescence spectrum. We investigate the generation of persistent charge and spin currents. The exploration of spin orientations manifests that by adjusting the strength of the spin-orbit interactions, the exciton can be constructed as a squeezed complex with specific spin polarization. Moreover, a coherently moving dipolar exciton acquires a nontrivial dual Aharonov-Casher phase, creating the possibility to generate persistent dipole currents and spin dipole currents. Our study reveals that in the presence of certain spin-orbit generated fields, the manipulation of the magnetic field provides a potential application for quantum-ring spinor excitons to be utilized in nano-scaled magneto-optical switches.

  13. Dirac spinors for doubly special relativity and κ-Minkowski noncommutative spacetime

    International Nuclear Information System (INIS)

    Agostini, Alessandra; Amelino-Camelia, Giovanni; Arzano, Michele

    2004-01-01

    We construct a Dirac equation that is consistent with one of the recently-proposed schemes for a 'doubly special relativity', a relativity with both an observer-independent velocity scale (still naturally identified with the speed-of-light constant) and an observer-independent length/momentum scale (possibly given by the Planck length/momentum). We find that the introduction of the second observer-independent scale only induces a mild deformation of the structure of Dirac spinors. We also show that our modified Dirac equation naturally arises in constructing a Dirac equation in the κ-Minkowski noncommutative spacetime. Previous, more heuristic studies had already argued for a possible role of doubly special relativity in κ-Minkowski, but remained vague on the nature of the consistency requirements that should be implemented in order to assure the observer-independence of the two scales. We find that a key role is played by the choice of a differential calculus in κ-Minkowski. A much-studied choice of the differential calculus does lead to our doubly special relativity Dirac equation, but a different scenario is encountered for another popular choice of differential calculus

  14. Spinor Casimir densities for a spherical shell in the global monopole spacetime

    International Nuclear Information System (INIS)

    Saharian, A A; Mello, E R Bezerra de

    2004-01-01

    We investigate the vacuum expectation values of the energy-momentum tensor and the fermionic condensate associated with a massive spinor field obeying the MIT bag boundary condition on a spherical shell in the global monopole spacetime. In order to do that, we use the generalized Abel-Plana summation formula. As we shall see, this procedure allows us to extract from the vacuum expectation values the contribution coming from the unbounded spacetime and to explicitly present the boundary induced parts. As regards the boundary induced contribution, two distinct situations are examined: the vacuum average effects inside and outside the spherical shell. The asymptotic behaviour of the vacuum densities is investigated near the sphere centre and near the surface, and at large distances from the sphere. In the limit of strong gravitational field corresponding to small values of the parameter describing the solid angle deficit in the global monopole geometry, the sphere induced expectation values are exponentially suppressed. We discuss, as a special case, the fermionic vacuum densities for the spherical shell on the background of the Minkowski spacetime. Previous approaches to this problem within the framework of the QCD bag models have been global and our calculation is a local extension of these contributions

  15. Multi-second magnetic coherence in a single domain spinor Bose–Einstein condensate

    Science.gov (United States)

    Palacios, Silvana; Coop, Simon; Gomez, Pau; Vanderbruggen, Thomas; Natali Martinez de Escobar, Y.; Jasperse, Martijn; Mitchell, Morgan W.

    2018-05-01

    We describe a compact, robust and versatile system for studying the macroscopic spin dynamics in a spinor Bose–Einstein condensate. Condensates of {}87{Rb} are produced by all-optical evaporation in a 1560 nm optical dipole trap, using a non-standard loading sequence that employs an ancillary 1529 nm beam for partial compensation of the strong differential light-shift induced by the dipole trap itself. We use near-resonant Faraday rotation probing to non-destructively track the condensate magnetization, and demonstrate few-Larmor-cycle tracking with no detectable degradation of the spin polarization. In the ferromagnetic F = 1 ground state, we observe the spin orientation between atoms in the condensate is preserved, such that they precess all together like one large spin in the presence of a magnetic field. We characterize this dynamics in terms of the single-shot magnetic coherence times {{ \\mathcal T }}1 and {{ \\mathcal T }}2* , and observe them to be of several seconds, limited only by the residence time of the atoms in the trap. At the densities used, this residence is restricted only by one-body losses set by the vacuum conditions.

  16. Bell Inequality, Einstein-Podolsky-Rosen Steering, and Quantum Metrology with Spinor Bose-Einstein Condensates.

    Science.gov (United States)

    Wasak, Tomasz; Chwedeńczuk, Jan

    2018-04-06

    We propose an experiment, where the Bell inequality is violated in a many-body system of massive particles. The source of correlated atoms is a spinor F=1 Bose-Einstein condensate residing in an optical lattice. We characterize the complete procedure-the local operations, the measurements, and the inequality-necessary to run the Bell test. We show how the degree of violation of the Bell inequality depends on the strengths of the two-body correlations and on the number of scattered pairs. We show that the system can be used to demonstrate the Einstein-Podolsky-Rosen paradox. Also, the scattered pairs are an excellent many-body resource for the quantum-enhanced metrology. Our results apply to any multimode system where the spin-changing collision drives the scattering into separate regions. The presented inquiry shows that such a system is versatile as it can be used for the tests of nonlocality, quantum metrology, and quantum information.

  17. The efficacy and safety of fixed-dose combination of amlodipine/benazepril in Chinese essential hypertensive patients not adequately controlled with benazepril monotherapy: a multicenter, randomized, double-blind, double-dummy, parallel-group clinical trial.

    Science.gov (United States)

    Yan, Pingping; Fan, Weihu

    2014-01-01

    This double-blind, double-dummy clinical trial evaluated the efficacy and safety of two strengths of fixed-dose combination of amlodipine/benazepril in Chinese hypertensive patients not adequately controlled with benazepril. Of 442 patients who received treatment with benazepril 10 mg for 4 weeks, 341 patients failed to achieve to diastolic blood pressure (DBP) benazepril 2.5/10 mg, or amlodipine/benazepril 5/10 mg, or benazepril 10 mg for 8 weeks. BP reductions with amodipinel/benazepril 2.5/10 mg (15.2/11.8 mmHg) or amlodipine/benazepril 5/10 mg (15.4/12.4 mmHg) were significantly greater than that with benazepril 10 mg (9.88/9.46 mmHg) at study end (p benazepril). BP control rate was 83.8% with amlodipine/benazepril 2.5/10 mg, 80.2% with amlodipine/benazepril 5/10 mg, 64.9% with benazepril 10 mg at study end (p benazepril). Three groups were generally well tolerated. Our study indicated that amlodipine/benazepril fixed-dose combination offered significant additional BP reductions and BP control rate compared with the continuation of benazepril monotherapy. No significant differences were observed in both BP reductions and BP control rate between amlodipine/benazepril 2.5/10 mg and amlodipine/benazepril 5/10 mg.

  18. The Distant Double Bond Determines the Fate of the Carboxylic Group in the Dissociative Photoionization of Oleic Acid.

    Science.gov (United States)

    Heringa, Maarten F; Slowik, Jay G; Goldmann, Maximilian; Signorell, Ruth; Hemberger, Patrick; Bodi, Andras

    2017-12-15

    The valence threshold photoionization of oleic acid has been studied using synchrotron VUV radiation and imaging photoelectron photoion coincidence (iPEPICO) spectroscopy. An oleic acid aerosol beam was impacted on a copper thermodesorber, heated to 130 °C, to evaporate the particles quantitatively. Upon threshold photoionization, oleic acid produces the intact parent ion first, followed by dehydration at higher energies. Starting at ca. 10 eV, a large number of fragment ions slowly rise suggesting several fragmentation coordinates with quasi-degenerate activation energies. However, water loss is the dominant low-energy dissociation channel, and it is shown to be closely related to the unsaturated carbon chain. In the lowest-barrier process, one of the four allylic hydrogen atoms is transferred to the carboxyl group to form the leaving water molecule and a cyclic ketone fragment ion. A statistical model to analyze the breakdown diagram and measured rate constants yields a 0 K appearance energy of 9.77 eV, which can be compared with the density functional theory result of 9.19 eV. Alternative H-transfer steps yielding a terminal C=O group are ruled out based on energetics and kinetics arguments. Some of the previous photoionization mass spectrometric studies also reported 2 amu and 26 amu loss fragment ions, corresponding to hydrogen and acetylene loss. We could not identify such peaks in the mass spectrum of oleic acid. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in topical treatment of eczema

    Directory of Open Access Journals (Sweden)

    Gandy JJ

    2011-09-01

    Full Text Available Justin J Gandy, Jacques R Snyman, Constance EJ van RensburgDepartment of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South AfricaBackground: The purpose of this study was to evaluate the efficacy and safety of carbohydrate-derived fulvic acid (CHD-FA in the treatment of eczema in patients two years and older.Methods: In this single-center, double-blind, placebo-controlled, parallel-group comparative study, 36 volunteers with predetermined eczema were randomly assigned to receive either the study drug or placebo twice daily for four weeks.Results: All safety parameters remained within normal limits, with no significant differences in either group. Significant differences were observed for both severity and erythema in the placebo and CHD-FA treated groups, and a significant difference was observed for scaling in the placebo-treated group. With regard to the investigator assessment of global response to treatment, a significant improvement was observed in the CHD-FA group when compared with the placebo group. A statistically significant decrease in visual analog scale score was observed in both groups, when comparing the baseline with the final results.Conclusion: CHD-FA was well tolerated, with no difference in reported side effects other than a short-lived burning sensation on application. CHD-FA significantly improved some aspects of eczema. Investigator assessment of global response to treatment with CHD-FA was significantly better than that with emollient therapy alone. The results of this small exploratory study suggest that CHD-FA warrants further investigation in the treatment of eczema.Keywords: fulvic acid, eczema, anti-inflammatory, efficacy, safety

  20. IR-UV double resonance spectroscopic investigation of phenylacetylene-alcohol complexes. Alkyl group induced hydrogen bond switching.

    Science.gov (United States)

    Singh, Prashant Chandra; Patwari, G Naresh

    2008-06-12

    The electronic transitions of phenylacetylene complexes with water and trifluoroethanol are shifted to the blue, while the corresponding transitions for methanol and ethanol complexes are shifted to the red relative to the phenylacetylene monomer. Fluorescence dip infrared (FDIR) spectra in the O-H stretching region indicate that, in all the cases, phenylacetylene is acting as a hydrogen bond acceptor to the alcohols. The FDIR spectrum in the acetylenic C-H stretching region shows Fermi resonance bands for the bare phenylacetylene, which act as a sensitive tool to probe the intermolecular structures. The FDIR spectra reveal that water and trifluoroethanol interact with the pi electron density of the acetylene C-C triple bond, while methanol and ethanol interact with the pi electron density of the benzene ring. It can be inferred that the hydrogen bonding acceptor site on phenylacetylene switches from the acetylene pi to the benzene pi with lowering in the partial charge on the hydrogen atom of the OH group. The most significant finding is that the intermolecular structures of water and methanol complexes are notably distinct, which, to the best of our knowledge, this is first such observation in the case of complexes of substituted benzenes.

  1. A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected].

    Science.gov (United States)

    Micallef, J; Soubrouillard, C; Guet, F; Le Guern, M E; Alquier, C; Bruguerolle, B; Blin, O

    2001-06-01

    This paper describes the psychomotor and mnesic effects of single oral doses of etifoxine (50 and 100 mg) and lorazepam (2 mg) in healthy subjects. Forty-eight healthy subjects were included in this randomized double blind, placebo controlled parallel group study [corrected]. The effects of drugs were assessed by using a battery of subjective and objective tests that explored mood and vigilance (Visual Analog Scale), attention (Barrage test), psychomotor performance (Choice Reaction Time) and memory (digit span, immediate and delayed free recall of a word list). Whereas vigilance, psychomotor performance and free recall were significantly impaired by lorazepam, neither dosage of etifoxine (50 and 100 mg) produced such effects. These results suggest that 50 and 100 mg single dose of etifoxine do not induce amnesia and sedation as compared to lorazepam.

  2. Fermion doubling on a lattice and topological aspects of chiral anomaly

    International Nuclear Information System (INIS)

    Goswami, G.; Bandyopadhyay, P.

    1997-01-01

    The problem of fermion doubling on a lattice has been discussed here from the specific geometrical properties of a lattice structure and topological aspects of chiral anomaly. It is argued that there cannot be chiral anomaly on a lattice and as such there cannot be any conserved charge. This unveils the root cause of fermion doubling, and the unwanted fermions just reflect the geometrical properties of a lattice and may be viewed as to represent the open-quotes fictitiousclose quotes chiral spinors associated with the lattice structure which make chiral fermions anomaly free. copyright 1997 American Institute of Physics

  3. Improvement of defecation in healthy individuals with infrequent bowel movements through the ingestion of dried Mozuku powder: a randomized, double-blind, parallel-group study

    Directory of Open Access Journals (Sweden)

    Masaki Matayoshi

    2017-09-01

    Full Text Available Background: Okinawa mozuku (Cladosiphon okamuranu is a type of edible seaweed of the family Chordariaceae that typically contains the polysaccharide fucoidan as a functional ingredient. In Okinawa, raw mozuku is eaten as vinegared mozuku together with vinegar or as tempura (deep-fried in batter. Polysaccharides such as fucoidan are generally known to regulate intestinal function, which is why we have used Okinawa mozuku to investigate this intestinal regulatory effect. Methods: The study was designed as a randomized, double-blind, parallel group study. Dried Okinawa mozuku powder at a dose of 2.4 g/day (1.0 g/day of fucoidan and a placebo not containing any dried Okinawa mozuku powder were each made into capsules and given to healthy men and women with infrequent weekly bowel movements (2–4 movements a week to ingest for eight weeks. We then investigated changes in the defecation situation, blood tests, and adverse events. Results: In the group that ingested the capsules containing dried Okinawa mozuku powder, the number of days with a bowel movement significantly increased compared with the placebo group after four weeks of ingestion (p < 0.05. Furthermore, after eight weeks of ingestion, the same increasing trend was seen compared with the placebo group (p = 0.0964. The volume of stool also increased significantly in the dried Okinawa mozuku powder group after eight weeks compared with the placebo group. In terms of blood tests and adverse events, no adverse events occurred that were the result of the test food. Conclusions: Ingestion of Okinawa mozuku was found to have a regulatory effect on intestinal function by promoting defecation in healthy individuals with a tendency for constipation. This demonstrated that Okinawa mozuku is a functional food capable of making defecation smoother and increasing the volume of stool.

  4. Ghost field realizations of the spinor $W_{2,s}$ strings based on the linear W(1,2,s) algebras

    OpenAIRE

    Liu, Yu-Xiao; Zhang, Li-Jie; Ren, Ji-Rong

    2005-01-01

    It has been shown that certain W algebras can be linearized by the inclusion of a spin-1 current. This Provides a way of obtaining new realizations of the W algebras. In this paper, we investigate the new ghost field realizations of the W(2,s)(s=3,4) algebras, making use of the fact that these two algebras can be linearized. We then construct the nilpotent BRST charges of the spinor non-critical W(2,s) strings with these new realizations.

  5. Ghost field realizations of the spinor W2,s strings based on the linear W1,2,s algebras

    International Nuclear Information System (INIS)

    Liu Yuxiao; Ren Jirong; Zhang Lijie

    2005-01-01

    It has been shown that certain W algebras can be linearized by the inclusion of a spin-1 current. This provides a way of obtaining new realizations of the W algebras. In this paper, we investigate the new ghost field realizations of the W 2,s (s=3,4) algebras, making use of the fact that these two algebras can be linearized. We then construct the nilpotent BRST charges of the spinor non-critical W 2,s strings with these new realizations. (author)

  6. Creating Spin-One Fermions in the Presence of Artificial Spin-Orbit Fields: Emergent Spinor Physics and Spectroscopic Properties

    Science.gov (United States)

    Kurkcuoglu, Doga Murat; de Melo, C. A. R. Sá

    2018-05-01

    We propose the creation and investigation of a system of spin-one fermions in the presence of artificial spin-orbit coupling, via the interaction of three hyperfine states of fermionic atoms to Raman laser fields. We explore the emergence of spinor physics in the Hamiltonian described by the interaction between light and atoms, and analyze spectroscopic properties such as dispersion relation, Fermi surfaces, spectral functions, spin-dependent momentum distributions and density of states. Connections to spin-one bosons and SU(3) systems is made, as well relations to the Lifshitz transition and Pomeranchuk instability are presented.

  7. Covariant spinor representation of iosp(d,2/2) and quantization of the spinning relativistic particle

    Energy Technology Data Exchange (ETDEWEB)

    Jarvis, P.D.; Corney, S.P.; Tsohantjis, I. [School of Mathematics and Physics, University of Tasmania, Hobart Tas (Australia)

    1999-12-03

    A covariant spinor representation of iosp(d,2/2) is constructed for the quantization of the spinning relativistic particle. It is found that, with appropriately defined wavefunctions, this representation can be identified with the state space arising from the canonical extended BFV-BRST quantization of the spinning particle with admissible gauge fixing conditions after a contraction procedure. For this model, the cohomological determination of physical states can thus be obtained purely from the representation theory of the iosp(d,2/2) algebra. (author)

  8. Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD A double-blind, randomised, non-inferiority, parallel-group, multicentre study

    Directory of Open Access Journals (Sweden)

    Andersson Eva

    2009-02-01

    Full Text Available Abstract Background Oral corticosteroids and inhaled bronchodilators with or without antibiotics represent standard treatment of COPD exacerbations of moderate severity. Frequent courses of oral steroids may be a safety issue. We wanted to evaluate in an out-patient setting whether a 2-week course of inhaled budesonide/formoterol would be equally effective for treatment of acute COPD exacerbations as standard therapy in patients judged by the investigator not to require hospitalisation. Methods This was a double-blind, randomised, non-inferiority, parallel-group, multicentre study comparing two treatment strategies; two weeks' treatment with inhaled budesonide/formoterol (320/9 μg, qid was compared with prednisolone (30 mg once daily plus inhaled formoterol (9 μg bid in patients with acute exacerbations of COPD attending a primary health care centre. Inclusion criteria were progressive dyspnoea for less than one week, FEV1 30–60% of predicted normal after acute treatment with a single dose of oral corticosteroid plus nebulised salbutamol/ipratropium bromide and no requirement for subsequent immediate hospitalisation, i.e the clinical status after the acute treatment allowed for sending the patient home. A total of 109 patients (mean age 67 years, 33 pack-years, mean FEV1 45% of predicted were randomized to two weeks' double-blind treatment with budesonide/formoterol or prednisolone plus formoterol and subsequent open-label budesonide/formoterol (320/9 μg bid for another 12 weeks. Change in FEV1 was the primary efficacy variable. Non-inferiority was predefined. Results Non-inferiority of budesonide/formoterol was proven because the lower limit of FEV1-change (97.5% CI was above 90% of the efficacy of the alternative treatment. Symptoms, quality of life, treatment failures, need for reliever medication (and exacerbations during follow-up did not differ between the groups. No safety concerns were identified. Conclusion High dose budesonide

  9. Evaluation of pulsing magnetic field effects on paresthesia in multiple sclerosis patients, a randomized, double-blind, parallel-group clinical trial.

    Science.gov (United States)

    Afshari, Daryoush; Moradian, Nasrin; Khalili, Majid; Razazian, Nazanin; Bostani, Arash; Hoseini, Jamal; Moradian, Mohamad; Ghiasian, Masoud

    2016-10-01

    Evidence is mounting that magnet therapy could alleviate the symptoms of multiple sclerosis (MS). This study was performed to test the effects of the pulsing magnetic fields on the paresthesia in MS patients. This study has been conducted as a randomized, double-blind, parallel-group clinical trial during the April 2012 to October 2013. The subjects were selected among patients referred to MS clinic of Imam Reza Hospital; affiliated to Kermanshah University of Medical Sciences, Iran. Sixty three patients with MS were included in the study and randomly were divided into two groups, 35 patients were exposed to a magnetic pulsing field of 4mT intensity and 15-Hz frequency sinusoidal wave for 20min per session 2 times per week over a period of 2 months involving 16 sessions and 28 patients was exposed to a magnetically inactive field (placebo) for 20min per session 2 times per week over a period of 2 months involving 16 sessions. The severity of paresthesia was measured by the numerical rating scale (NRS) at 30, 60days. The study primary end point was NRS change between baseline and 60days. The secondary outcome was NRS change between baseline and 30days. Patients exposing to magnetic field showed significant paresthesia improvement compared with the group of patients exposing to placebo. According to our results pulsed magnetic therapy could alleviate paresthesia in MS patients .But trials with more patients and longer duration are mandatory to describe long-term effects. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. The effect of a corticosteroid cream and a barrier-strengthening moisturizer in hand eczema. A double-blind, randomized, prospective, parallel group clinical trial.

    Science.gov (United States)

    Lodén, M; Wirén, K; Smerud, K T; Meland, N; Hønnås, H; Mørk, G; Lützow-Holm, C; Funk, J; Meding, B

    2012-05-01

    Hand eczema is a common and persistent disease with a relapsing course. Clinical data suggest that once daily treatment with corticosteroids is just as effective as twice daily treatment. The aim of this study was to compare once and twice daily applications of a strong corticosteroid cream in addition to maintenance therapy with a moisturizer in patients with a recent relapse of hand eczema. The study was a parallel, double-blind, randomized, clinical trial on 44 patients. Twice daily application of a strong corticosteroid cream (betamethasone valerate 0.1%) was compared with once daily application, where a urea-containing moisturizer was substituted for the corticosteroid cream in the morning. The investigator scored the presence of eczema and the patients judged the health-related quality of life (HRQoL) using the Dermatology Life Quality Index (DLQI), which measures how much the patient's skin problem has affected his/her life over the past week. The patients also judged the severity of their eczema daily on a visual analogue scale. Both groups improved in terms of eczema and DLQI. However, the clinical scoring demonstrated that once daily application of corticosteroid was superior to twice daily application in diminishing eczema, especially in the group of patients with lower eczema scores at inclusion. Twice daily use of corticosteroids was not superior to once daily use in treating eczema. On the contrary, the clinical assessment showed a larger benefit from once daily treatment compared with twice daily, especially in the group of patients with a moderate eczema at inclusion. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

  11. Comments on the symmetry of AdS6 solutions in string/M-theory and Killing spinor equations

    Directory of Open Access Journals (Sweden)

    Hyojoong Kim

    2016-09-01

    Full Text Available It was recently pointed out in [1] that AdS6 solutions in IIB theory enjoy an extended symmetry structure and the consistent truncation to D=4 internal space leads to a nonlinear sigma model with target SL(3,R/SO(2,1. We continue to study the purely bosonic D=4 effective action, and elucidate how the addition of scalar potential term still allows Killing spinor equations in the absence of gauge fields. In particular, the potential turns out to be a single diagonal component of the coset representative. Furthermore, we perform a general analysis of the integrability conditions of Killing spinor equations and establish that the effective action can be in fact generalized to arbitrary sizes and signatures, e.g. with target SL(n,R/SO(p,n−p and the scalar potential expressible by a single diagonal component of the coset representative. We also comment on a similar construction and its generalizations of effective D=5 purely bosonic non-linear sigma model action related to AdS6 in M-theory.

  12. Electrical properties of SAM-modified ITO surface using aromatic small molecules with double bond carboxylic acid groups for OLED applications

    International Nuclear Information System (INIS)

    Can, Mustafa; Havare, Ali Kemal; Aydın, Hasan; Yagmurcukardes, Nesli; Demic, Serafettin; Icli, Sıddık; Okur, Salih

    2014-01-01

    Graphical abstract: - Highlights: • We report that the performance of OLED consist of aromatic small molecules with double bond carboxylic acid groups on ITO surface. • The OLED devices were tested in terms of electrical and optical characteristics. • The I–V results show that OLEDs with SAM-modified ITO surface have lower turn on voltages than OLED configurations without SAMs. - Abstract: 5-[(3-Methylphenyl)(phenyl)amino]isophthalic acid (5-MePIFA) and 5-(diphenyl)amino]isophthalic acid (5-DPIFA) organic molecules were synthesized to form self-assembled monolayer on indium tin oxide (ITO) anode to enhance hole transport from ITO to organic hole transport layers such as TPD. The modified surface was characterized by scanning tunneling microscopy (STM). The change in the surface potential was measured by Kelvin probe force microscopy (KPFM). Our Kelvin probe force microscopy (KPFM) measurements showed that the surface potentials increased more than 100 mV with reference to bare indium tin-oxide. The results show that the threshold voltage on OLEDs with modified ITO is lowered significantly compared to OLEDs with unmodified ITO. The hole mobility of TPD has been estimated using space–charge-limited current measurements (SCLC)

  13. Electrical properties of SAM-modified ITO surface using aromatic small molecules with double bond carboxylic acid groups for OLED applications

    Energy Technology Data Exchange (ETDEWEB)

    Can, Mustafa [Izmir Katip Celebi University, Faculty of Engineering, Department of Engineering Sciences, Çiğli, Izmir (Turkey); Havare, Ali Kemal [Toros University, Faculty of Engineering, Electric and Electronic Department, Mersin (Turkey); Aydın, Hasan; Yagmurcukardes, Nesli [Izmir Institute of Technology, Material Science and Engineering, Izmir (Turkey); Demic, Serafettin [Izmir Katip Celebi University, Faculty of Engineering, Department of Material Science and Engineering, Çiğli, Izmir (Turkey); Icli, Sıddık [Ege University, Solar Energy Institute, Izmir (Turkey); Okur, Salih, E-mail: salih.okur@ikc.edu.tr [Izmir Katip Celebi University, Faculty of Engineering, Department of Material Science and Engineering, Çiğli, Izmir (Turkey)

    2014-09-30

    Graphical abstract: - Highlights: • We report that the performance of OLED consist of aromatic small molecules with double bond carboxylic acid groups on ITO surface. • The OLED devices were tested in terms of electrical and optical characteristics. • The I–V results show that OLEDs with SAM-modified ITO surface have lower turn on voltages than OLED configurations without SAMs. - Abstract: 5-[(3-Methylphenyl)(phenyl)amino]isophthalic acid (5-MePIFA) and 5-(diphenyl)amino]isophthalic acid (5-DPIFA) organic molecules were synthesized to form self-assembled monolayer on indium tin oxide (ITO) anode to enhance hole transport from ITO to organic hole transport layers such as TPD. The modified surface was characterized by scanning tunneling microscopy (STM). The change in the surface potential was measured by Kelvin probe force microscopy (KPFM). Our Kelvin probe force microscopy (KPFM) measurements showed that the surface potentials increased more than 100 mV with reference to bare indium tin-oxide. The results show that the threshold voltage on OLEDs with modified ITO is lowered significantly compared to OLEDs with unmodified ITO. The hole mobility of TPD has been estimated using space–charge-limited current measurements (SCLC)

  14. Development of a universal double-digest RAD sequencing approach for a group of nonmodel, ecologically and economically important insect and fish taxa.

    Science.gov (United States)

    Burford Reiskind, M O; Coyle, K; Daniels, H V; Labadie, P; Reiskind, M H; Roberts, N B; Roberts, R B; Schaff, J; Vargo, E L

    2016-11-01

    The generation of genome-scale data is critical for a wide range of questions in basic biology using model organisms, but also in questions of applied biology in nonmodel organisms (agriculture, natural resources, conservation and public health biology). Using a genome-scale approach on a diverse group of nonmodel organisms and with the goal of lowering costs of the method, we modified a multiplexed, high-throughput genomic scan technique utilizing two restriction enzymes. We analysed several pairs of restriction enzymes and completed double-digestion RAD sequencing libraries for nine different species and five genera of insects and fish. We found one particular enzyme pair produced consistently higher number of sequence-able fragments across all nine species. Building libraries off this enzyme pair, we found a range of usable SNPs between 4000 and 37 000 SNPS per species and we found a greater number of usable SNPs using reference genomes than de novo pipelines in STACKS. We also found fewer reads in the Read 2 fragments from the paired-end Illumina Hiseq run. Overall, the results of this study provide empirical evidence of the utility of this method for producing consistent data for diverse nonmodel species and suggest specific considerations for sequencing analysis strategies. © 2016 John Wiley & Sons Ltd.

  15. Exact self-consistent solutions to the interacting spinor and scalar field equations in Bianchi type-I space-time

    International Nuclear Information System (INIS)

    Alvarado, R.; Rybakov, Yu.P.; Shikin, G.N.; Saha, B.

    1995-01-01

    Self-consistent solutions to the system of spinor and scalar field equations in General Relativity are studied for the case of Bianchi type-I space-time. The absence of initial singularity should be emphasized for some types of solutions and also the isotropic mode of space-time expansion in some special cases. 3 refs

  16. Pharmacokinetics, safety, and tolerability of varenicline in healthy adolescent smokers: a multicenter, randomized, double-blind, placebo-controlled, parallel-group study.

    Science.gov (United States)

    Faessel, Helene; Ravva, Patanjali; Williams, Kathryn

    2009-01-01

    Varenicline is approved as an aid to smoking cessation in adults aged > or =18 years. The goal of this study was to characterize the multiple-dose pharmacokinetics, safety, and tolerability of varenicline in adolescent smokers. This multicenter, randomized, double-blind, placebo-controlled, parallel-group study enrolled healthy 12- to 16-year-old smokers (> or =3 cigarettes daily) into high-body-weight (>55 kg) and low-body-weight (daily. The apparent renal clearance (CL/F) and volume of distribution (V/F) of varenicline and the effect of body weight on these parameters were estimated using nonlinear mixed-effects modeling. The high-body-weight group consisted of 35 subjects (65.7% male; 77.1% white; mean age, 15.2 years). The low-body-weight group consisted of 37 subjects (37.8% male; 48.6% white; mean age, 14.3 years). The pharmacokinetic parameters of varenicline were dose proportional over the dose range from 0.5 to 2 mg/d. The CL/F for a 70-kg adolescent was 10.4 L/h, comparable to that in a 70-kg adult. The estimated varenicline V/F was decreased in individuals of small body size, thus predicting a varenicline C(max) approximately 30% greater in low-body-weight subjects than in high-body-weight subjects. In high-body-weight subjects, steady-state varenicline exposure, as represented by the AUC(0-24), was 197.0 ng . h/mL for varenicline 1 mg BID and 95.7 ng . h/mL for varenicline 0.5 mg BID, consistent with values reported previously in adult smokers at the equivalent doses. In low-body-weight subjects, varenicline exposure was 126.3 ng . h/mL for varenicline 0.5 mg BID and 60.1 ng . h/mL for varenicline 0.5 mg once daily, values at the lower end of the range observed previously in adults at doses of 1 mg BID and 0.5 mg BID, respectively. Among high-body-weight subjects, adverse events (AEs) were reported by 57.1% of subjects in both the high- and low-dose varenicline groups and by 14.3% of subjects in the placebo group; among low-body-weight subjects, AEs

  17. Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies

    DEFF Research Database (Denmark)

    Kajdasz, Daniel K; Iyengar, Smriti; Desaiah, Durisala

    2007-01-01

    peripheral neuropathic pain (DPNP). METHODS: Data were pooled from three 12-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies in which patients received 60 mg duloxetine either QD or BID or placebo. NNT was calculated based on rates of response (defined as >or=30...

  18. Deconfinement on ℝ2×SL1×Sβ1 for all gauge groups and duality to double Coulomb gas

    International Nuclear Information System (INIS)

    Teeple, Brett

    2016-01-01

    I study finite-temperature N=1 super Yang-Mills for any gauge group G=A N ,B N ,C N ,D N ,E 6,7,8 ,F 4 ,G 2 , compactified from four dimensions on a torus, ℝ 2 ×S L 1 ×S β 1 . I examine in particular the low temperature regime L≪β=1/T, where L is the length of the spatial circle with periodic boundary conditions and with anti-periodic boundary conditions for the adjoint gauginos along the thermal cycle S β 1 . For small such L we are in a regime were semiclassical calculations can be performed and a transition occurs at T c much smaller than 1/NL. The transition is mediated by the competition between non-perturbative objects including ‘exotic’ topological molecules: neutral and magnetic bions composed of BPS and KK monopole constituents, with r=rank(G) different charges in the co-root lattice of the gauge group G, and the perturbative electrically charged W-bosons (along with their wino superpartners). The difference from non-SUSY theories here is that the Higgsing along the thermal cycle gives rise to a light modulus scalar field which couples to both bion-instantons and the W-bosons, and mediates a transition near T c where the bions and W-bosons compete with equal strengths. The transition is seen to be similar to previous studies on ℝ 3 ×S L 1 http://dx.doi.org/10.1007/JHEP11(2013)142; http://dx.doi.org/10.1007/JHEP09(2014)040; http://dx.doi.org/10.1007/JHEP03(2013)087; http://dx.doi.org/10.1007/JHEP09(2013)128 with general gauge group where a first order transition was found for all groups, but a second order one for the case of SU(2) on the torus ℝ 2 ×S L 1 ×S β 1 , which was subjected to lattice studies in http://dx.doi.org/10.1007/JHEP11(2013)142. I determine a duality to a double Coulomb gas of neutral and magnetic bions of different charges of their constituent monopole-instantons, and W-bosons of both scalar and electric charges. Aharanov-Bohm interactions exist between magnetic bions and W-bosons, and scalar charges of W-bosons and

  19. [Deficient lactose digestion and intolerance in a group of patients with chronic nonspecific ulcerative colitis: a controlled, double-blind, cross-over clinical trial].

    Science.gov (United States)

    Cabrera-Acosta, G A; Milke-García, M P; Ramírez-Iglesias, M T; Uscanga, L

    2012-01-01

    Despite the fact that the frequency of hypolactasia and lactose intolerance is similar in both chronic idiopathic ulcerative colitis patients and the general population, the elimination of dairy products from the patient's diet is a habitual recommendation. Hypolactasia is common in Mexico, but its relation to chronic idiopathic ulcerative colitis has not been established. To evaluate lactose digestion and lactose intolerance in persons with chronic idiopathic ulcerative colitis. Thirty-nine patients with confirmed chronic idiopathic ulcerative colitis diagnosis were included in the study (mean: 31 years, range: 15 to 38). Twenty-two patients presented with rectosigmoid involvement and the remaining patients with pancolitis. No patient showed inflammatory activity according to the Truelove-Witts criteria and all consumed dairy products before diagnosis. A prospective, controlled, double-blind, cross-over study was designed. Patients randomly received 12.5 g of lactose or maltose in 250 cc water- each test 72 hours apart - and ydrogen was measured in exhaled air before disaccharide ingestion and then every 30 minutes for 3 hours. Digestion was considered deficient when there was an increase in hydrogen of at least 20 ppm. Symptom intensities were evaluated by Visual Analog Scales before, during, and after the hydrogen test. Differences between the groups were contrasted with the Mann-Whitney U and the Wilcoxon tests. Eighteen patients (46%) presented with deficient lactose digestion. No significant differences were found in the symptoms, extension, or progression of chronic idiopathic ulcerative colitis between patients that could digest and those that could not digest lactose. No patient had symptom exacerbation with the disaccharides used. Lactose digestion deficiency frequency is similar in subjects with chronic idiopathic ulcerative colitis and in healthy individuals in Mexico. We do not know whether higher doses could have some effect, but symptoms in patients

  20. The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel-group, double-blind, placebo-controlled multicentre study.

    Science.gov (United States)

    Schwizer, Werner; Menne, Dieter; Schütze, Kurt; Vieth, Michael; Goergens, Reiner; Malfertheiner, Peter; Leodolter, Andreas; Fried, Michael; Fox, Mark R

    2013-08-01

    This study aimed to resolve controversy regarding the effects of Helicobacter pylori eradication therapy and H. pylori infection in gastro-oesophageal reflux disease. A randomized, double-blind, multicentre trial was performed in patients presenting with reflux symptoms. H. pylori-positive patients were randomized to receive either antibiotics or placebo for 7 days. H. pylori-negative patient controls received placebo. All received esomeprazole 20 mg b.d. for 7 days, followed by 40 mg o.d. to complete an 8-week course, and were followed up for 32 weeks by telephone. In this study, 198/589 (34%) patients were H. pylori-positive and 113 H. pylori-negative patients served as controls. Baseline endoscopy revealed 63% Los Angeles grade 0A and 37% Los Angeles grade BCD oesophagitis with no difference between patient groups. Symptom improvement on esomeprazole was seen in 89%. H. pylori eradication was successful in 82%. H. pylori eradication had no effect on symptomatic relapse (hazard ratio 1.15, 95% CI 0.74-1.8; p = 0.5). Overall, H. pylori-positive patients had a lower probability of relapse compared to H. pylori-negative controls (hazard ratio 0.6, 95% CI 0.43-0.85; p = 0.004). Relapse hazard was modulated also by oesophagitis grade (BCD vs. 0A, hazard ratio 2.1, 95% CI 1.5-3.0). Relapse of gastro-oesophageal reflux disease symptoms after a course of high dose acid suppression took longer for H. pylori-positive patients than H. pylori-negative controls; however eradication therapy had no effect on the risk of relapse; ClincialTrials.gov number, NCT00574925.

  1. Double-blind,parallel group, placebo-controlledstudy of Kjellmaniella crassifoliaMiyabe (Gagomein human: The potential of Gagometoactivatethe immune system

    Directory of Open Access Journals (Sweden)

    Jun Nishihira

    2017-10-01

    Full Text Available Background: Marine brown algae, Kjellmaniella crassifolia Miyabe (Gagome is extensively harvested in Northern Japan and is known to help improve the immune system and prevent lifestyle diseases by its functional constituents, particularly the polysaccharide fucoidan. However, since most scientific findings come from animal studies, we examined its potential effectiveness in humans to raise immune functions, using small amounts of Gagome to avoid overconsumption of iodide. Methods: We set up a double-blind, placebo-controlled clinical trial (n=30 subjects for Gagome consumption; n=30 for placebo, in which 0.8 gram/day of Gagome containing 200 mg as dietary fiber (ca. 80 mg as fucoidan was ingested for 8 weeks. The primary end-point was natural killer (NK cell activity while other immune-related biomarkers, such as immunoglobulins (IgM and IgA and cytokines (IL-12 and IFN-g were secondary end-points. Results: No adverse effects were observed during the course of the clinical trial. We found that 8-week daily Gagome intake raised NK cell activities for the group with a relatively higher baseline number of NK cells (p=0.03. We also demonstrated that Gagome intake exerted a tendency to stimulate IgA secretion. These results indicate the possibility that Gagome intake may potentiate host defense systems in human as seen in animal studies. Conclusion: In this study, we used small amounts of Gagome (0.8 g daily as an active test sample to avoid overconsumption of iodide, and found that this amount could enhance NK cell activities, particularly in the subclass with initially higher NK cell numbers. We also found an appreciable increment of IgA. With all of these facts, it seems that Gagome intake activates immune responses that contribute to the promotion of health through stimulation of the immune system.

  2. Effects of policosanol on borderline to mildly elevated serum total cholesterol levels: a prospective, double-blind, placebo-controlled, parallel-group, comparative study

    Directory of Open Access Journals (Sweden)

    Gladys Castaño, PhD

    2003-09-01

    Full Text Available Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Clinical studies have shown that lowering elevated serum cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C, is beneficial for patients with borderline to mildly elevated serum total cholesterol (TC levels (5.0–6.0 mmol/L. Policosanol is a cholesterol-lowering drug made from purified sugar cane wax. The therapeutic range of policosanol is 5 to 20 mg/d. Objective: This study investigated the efficacy and tolerability of policosanol 5 mg/d in patients with borderline to mildly elevated serum TC levels. Methods: This 14-week, single-center, prospective, double-blind, placebo-controlled, parallel-group, comparative study was conducted in men and women aged 25 to 75 years with a serum TC level ≥4.8 to <6.0 mmol/L. After a 6-week run-in period in which patients were placed on therapeutic lifestyle changes, in particular a cholesterol-lowering diet, patients were randomly assigned to receive policosanol 5-mg tablets or placebo tablets once daily with the evening meal for 8 weeks, and the diet was continued throughout the study. Lipid profile variables, safety indicators, adverse events (AEs, and compliance with study medications were assessed. Results: One hundred patients (71 women, 29 men; mean [SD] age, 52 [10] years entered the study after the dietary run-in period. After 8 weeks of treatment, the mean (SD serum LDL-C level decreased significantly in the policosanol group (P<0.001 vs baseline and placebo from 3.57 (0.30 mmol/L to 2.86 (0.41 mmol/L (change, −19.9%. Significantly more patients in the policosanol group (42 patients [84%] achieved a ≥15% decrease in serum LDL-C than in the placebo group (2 patients [4%] (P<0.001. Also in the policosanol group, the mean (SD serum TC level decreased significantly, from 5.20 (0.22 mmol/L to 4.56 (0.44 mmol/L (P<0.001 vs baseline and placebo (change, −12.3%; the mean (SD triglyceride (TG

  3. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

    OpenAIRE

    Rascol, O.; Brooks, D.J.; Melamed, E.; Oertel, W.; Poewe, W.; Stocchi, F.; Tolosa, E.; LARGO study group

    2005-01-01

    Lancet. 2005 Mar 12-18;365(9463):947-54. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Rascol O, Brooks DJ, Melamed E, Oertel W, Poewe W, Stocchi F, Tolosa E; LARGO study group. Clinical Investigation Centre, Department of Clinical Pharmacology, University Hospital, Toulouse, France. ...

  4. Fuzzy Killing spinors and supersymmetric D4 action on the fuzzy 2-sphere from the ABJM model

    International Nuclear Information System (INIS)

    Nastase, Horatiu; Papageorgakis, Constantinos

    2009-01-01

    Our recent construction arXiv:0903.3966 for the fuzzy 2-sphere in terms of bifundamentals, discovered in the context of the ABJM model, is shown to be explicitly equivalent to the usual (adjoint) fuzzy sphere construction. The matrices G-tilde α that define it play the role of fuzzy Killing spinors on the 2-sphere, out of which all spherical harmonics are constructed. Starting from the quadratic fluctuation action around these solutions in the mass-deformed ABJM theory, we recover a supersymmetric D4-brane action wrapping a 2-sphere, including fermions. We obtain both the usual D4 action with an unusual x-dependence on the sphere, as well as a twisted version in terms of the usual x-dependence, and contrast our result with the Maldacena-Nunez case of a D5 wrapping an S 2 . The twisted and unwisted fields are related by the same matrix G-tilde α .

  5. Physical symmetry groups and associated bundles in field theory

    International Nuclear Information System (INIS)

    Crumeyrolle, A.

    1986-01-01

    A previous paper, ''Some geometrical consequences of physical symmetries'' describes in some detail invariant submanifolds of the linear representation space C /sup 4m/ for the physical symmetry group : SU(2,2)xSU(m) and its subgroup PxSU(m). In this paper the author intends to give a geometric version using homogeneous spaces and a spinorial approach. Some concrete orbits by means of spinor structures considered in the modern scope and some plausible physical consequences are discussed

  6. Anomalous tunneling of collective excitations and effects of superflow in the polar phase of a spin-1 spinor Bose-Einstein condensate

    International Nuclear Information System (INIS)

    Watabe, Shohei; Ohashi, Yoji; Kato, Yusuke

    2011-01-01

    We investigate tunneling properties of collective modes in the polar phase of a spin-1 spinor Bose-Einstein condensate (BEC). This spinor BEC state has two kinds of gapless modes (i.e., Bogoliubov and spin-wave). Within the framework of mean-field theory at T=0, we show that these Goldstone modes exhibit perfect transmission in the low-energy limit. Their anomalous tunneling behavior still holds in the presence of superflow, except in the critical current state. In the critical current state, while the tunneling of Bogoliubov mode is accompanied by finite reflection, the spin wave still exhibits perfect transmission, unless the strengths of spin-dependent and spin-independent interactions take the same value. We discuss the relation between perfect transmission of a spin wave and underlying superfluidity through a comparison of wave functions of the spin wave and the condensate.

  7. Posttreatment prostatic-specific antigen doubling time as a surrogate endpoint for prostate cancer-specific survival: An analysis of Radiation Therapy Oncology Group Protocol 92-02

    International Nuclear Information System (INIS)

    Valicenti, Richard K.; DeSilvio, Michelle; Hanks, Gerald E.; Porter, Arthur; Brereton, Harmar; Rosenthal, Seth A.; Shipley, William U.; Sandler, Howard M.

    2006-01-01

    Purpose: We evaluated whether posttreatment prostatic-specific antigen doubling time (PSADT) was predictive of prostate cancer mortality by testing the Prentice requirements for a surrogate endpoint. Methods and Materials: We analyzed posttreatment PSA measurements in a cohort of 1,514 men with localized prostate cancer (T2c-4 and PSA level Cox = 0.002), PSADT Cox Cox Cox Cox = 0.4). The significant posttreatment PSADTs were also significant predictors of CSS (p Cox < 0.001). After adjusting for T stage, Gleason score and PSA, all of Prentice's requirements were not met, indicating that the effect of PSADT on CSS was not independent of the randomized treatment. Conclusions: Prostatic specific antigen doubling time is significantly associated with CSS, but did not meet all of Prentice's requirements for a surrogate endpoint of CSS. Thus, the risk of dying of prostate cancer is not fully explained by PSADT

  8. Group Theory with Applications in Chemical Physics

    Science.gov (United States)

    Jacobs, Patrick

    2005-10-01

    Group Theory is an indispensable mathematical tool in many branches of chemistry and physics. This book provides a self-contained and rigorous account on the fundamentals and applications of the subject to chemical physics, assuming no prior knowledge of group theory. The first half of the book focuses on elementary topics, such as molecular and crystal symmetry, whilst the latter half is more advanced in nature. Discussions on more complex material such as space groups, projective representations, magnetic crystals and spinor bases, often omitted from introductory texts, are expertly dealt with. With the inclusion of numerous exercises and worked examples, this book will appeal to advanced undergraduates and beginning graduate students studying physical sciences and is an ideal text for use on a two-semester course. An introductory and advanced text that comprehensively covers fundamentals and applications of group theory in detail Suitable for a two-semester course with numerous worked examples and problems Includes several topics often omitted from introductory texts, such as rotation group, space groups and spinor bases

  9. Double Trouble

    NARCIS (Netherlands)

    Elsaesser, Thomas; Kievit, Robert; Simons, Jan

    1994-01-01

    Double Trouble highlights the career of Dutch scriptwriter and television producer Chiem van Houweninge, well-known for his long-running TV comedy series and as author of episodes for TV detective series. Double Trouble gives Van Houweninge's own views on writing and filming in television prime

  10. T-dualization of type II superstring theory in double space

    Energy Technology Data Exchange (ETDEWEB)

    Nikolic, B.; Sazdovic, B. [University of Belgrade, Institute of Physics Belgrade, Belgrade (Serbia)

    2017-03-15

    In this article we offer a new interpretation of the T-dualization procedure of type II superstring theory in the double space framework. We use the ghost free action of type II superstring in pure spinor formulation in approximation of constant background fields up to the quadratic terms. T-dualization along any subset of the initial coordinates, x{sup a}, is equivalent to the permutation of this subset with subset of the corresponding T-dual coordinates, y{sub a}, in double space coordinate Z{sup M} = (x{sup μ}, y{sub μ}). Requiring that the T-dual transformation law after the exchange x{sup a} <-> y{sub a} has the same form as the initial one, we obtain the T-dual NS-NS and NS-R background fields. The T-dual R-R field strength is determined up to one arbitrary constant under some assumptions. The compatibility between supersymmetry and T-duality produces a change of bar spinors and R-R field strength. If we dualize an odd number of dimensions x{sup a}, such a change flips type IIA/B to type II B/A. If we T-dualize the time-like direction, one imaginary unit i maps type II superstring theories to type II{sup *} ones. (orig.)

  11. Determinants of obesity among men with the lewis double-negative blood group: a genetic marker of obesity-the Copenhagen Male Study

    DEFF Research Database (Denmark)

    Gyntelberg, Finn; Hein, Hans Ole; Suadicani, Poul

    2011-01-01

    Middle-aged and elderly men with the Lewis blood group phenotype Le(a-b-), have a two-fold higher prevalence of obesity than others. We investigated if the association could be ascribed to differences in lifestyle, or if obesity determinants had a different impact in this group....

  12. Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients.

    Science.gov (United States)

    Abe, Koji; Itoyama, Yasuto; Sobue, Gen; Tsuji, Shoji; Aoki, Masashi; Doyu, Manabu; Hamada, Chikuma; Kondo, Kazuoki; Yoneoka, Takatomo; Akimoto, Makoto; Yoshino, Hiide

    2014-12-01

    Our objective was to confirm the efficacy and safety of edaravone in amyotrophic lateral sclerosis (ALS) patients. We conducted a 36-week confirmatory study, consisting of 12-week pre-observation period followed by 24-week treatment period. Patients received placebo or edaravone i.v. infusion over 60 min for the first 14 days in cycle 1, and for 10 of the first 14 days during cycles 2 to 6. The efficacy primary endpoint was changed in the revised ALS functional rating scale (ALSFRS-R) scores during the 24-week treatment. Patients were treated with placebo (n = 104) and edaravone (n = 102). Changes in ALSFRS-R during the 24-week treatment were -6.35 ± 0.84 in the placebo group (n = 99) and -5.70 ± 0.85 in the edaravone group (n = 100), with a difference of 0.65 ± 0.78 (p = 0.411). Adverse events amounted to 88.5% (92/104) in the placebo group and 89.2% (91/102) in the edaravone group. In conclusion, the reduction of ALSFRS-R was smaller in the edaravone group than in the placebo group, but efficacy of edaravone for treatment of ALS was not demonstrated. Levels and frequencies of reported adverse events were similar in the two groups.

  13. Tonks-Girardeau and super-Tonks-Girardeau states of a trapped one-dimensional spinor Bose gas

    International Nuclear Information System (INIS)

    Girardeau, M. D.

    2011-01-01

    A harmonically trapped, ultracold, one-dimensional (1D) spin-1 Bose gas with strongly repulsive or attractive 1D even-wave interactions induced by a three-dimensional (3D) Feshbach resonance is studied. The exact ground state, a hybrid of Tonks-Girardeau (TG) and ideal Fermi gases, is constructed in the TG limit of infinite even-wave repulsion by a spinor Fermi-Bose mapping to a spinless ideal Fermi gas. It is then shown that in the limit of infinite even-wave attraction this same state remains an exact many-body eigenstate, now highly excited relative to the collapsed generalized McGuire-cluster ground state, showing that the hybrid TG state is completely stable against collapse to this cluster ground state under a sudden switch from infinite repulsion to infinite attraction. It is shown to be the TG limit of a hybrid super-Tonks-Girardeau (STG) state, which is metastable under a sudden switch from finite but very strong repulsion to finite but very strong attraction. It should be possible to create it experimentally by a sudden switch from strongly repulsive to strongly attractive interaction, as in the recent Innsbruck experiment on a spin-polarized bosonic STG gas. In the case of strong attraction, there should also exist another STG state of much lower energy, consisting of strongly bound dimers, a bosonic analog of a recently predicted STG state which is an ultracold gas of strongly bound bosonic dimers of fermionic atoms, but it is shown that this STG state cannot be created by such a switch from strong repulsion to strong attraction.

  14. Semiclassical equivalence of Green–Schwarz and pure–spinor/hybrid formulations of superstrings in AdS5 × S5 and AdS2 × S2 × T6

    International Nuclear Information System (INIS)

    Cagnazzo, Alessandra; Sorokin, Dmitri; Tseytlin, Arkady A; Wulff, Linus

    2013-01-01

    We demonstrate the equivalence between the worldsheet one-loop partition functions computed near classical string solutions in the Green–Schwarz and in the pure–spinor formulations of superstrings in AdS 5 × S 5 . While their bosonic sectors are the same in the conformal gauge, their fermionic sectors superficially appear to be very different (first versus second-derivative kinetic terms, presence versus absence of fermionic gauge symmetry). Still, we show that the quadratic fluctuation spectrum of 16 fermionic modes of the pure–spinor formulation is the same as in the Green–Schwarz superstring and the contribution of the extra ‘massless’ fermionic modes cancels against that of the pure–spinor ghosts. We also provide evidence for a similar semiclassical equivalence between the Green–Schwarz and the hybrid formulations of superstrings in AdS 2 × S 2 × T 6 by studying several particular examples of string solutions. (paper)

  15. Prospective Randomized Double-Blind Pilot Study of Site-Specific Consensus Atlas Implementation for Rectal Cancer Target Volume Delineation in the Cooperative Group Setting

    International Nuclear Information System (INIS)

    Fuller, Clifton D.; Nijkamp, Jasper; Duppen, Joop C.; Rasch, Coen R.N.; Thomas, Charles R.; Wang, Samuel J.; Okunieff, Paul; Jones, William E.; Baseman, Daniel; Patel, Shilpen; Demandante, Carlo G.N.; Harris, Anna M.; Smith, Benjamin D.; Katz, Alan W.; McGann, Camille

    2011-01-01

    Purpose: Variations in target volume delineation represent a significant hurdle in clinical trials involving conformal radiotherapy. We sought to determine the effect of a consensus guideline-based visual atlas on contouring the target volumes. Methods and Materials: A representative case was contoured (Scan 1) by 14 physician observers and a reference expert with and without target volume delineation instructions derived from a proposed rectal cancer clinical trial involving conformal radiotherapy. The gross tumor volume (GTV), and two clinical target volumes (CTVA, including the internal iliac, presacral, and perirectal nodes, and CTVB, which included the external iliac nodes) were contoured. The observers were randomly assigned to receipt (Group A) or nonreceipt (Group B) of a consensus guideline and atlas for anorectal cancers and then instructed to recontour the same case/images (Scan 2). Observer variation was analyzed volumetrically using the conformation number (CN, where CN = 1 equals total agreement). Results: Of 14 evaluable contour sets (1 expert and 7 Group A and 6 Group B observers), greater agreement was found for the GTV (mean CN, 0.75) than for the CTVs (mean CN, 0.46-0.65). Atlas exposure for Group A led to significantly increased interobserver agreement for CTVA (mean initial CN, 0.68, after atlas use, 0.76; p = .03) and increased agreement with the expert reference (initial mean CN, 0.58; after atlas use, 0.69; p = .02). For the GTV and CTVB, neither the interobserver nor the expert agreement was altered after atlas exposure. Conclusion: Consensus guideline atlas implementation resulted in a detectable difference in interobserver agreement and a greater approximation of expert volumes for the CTVA but not for the GTV or CTVB in the specified case. Visual atlas inclusion should be considered as a feature in future clinical trials incorporating conformal RT.

  16. Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting

    Science.gov (United States)

    Fuller, Clifton D.; Nijkamp, Jasper; Duppen, Joop; Rasch, Coen R.N.; Thomas, Charles R.; Wang, Samuel J.; Okunieff, Paul; Jones, William E.; Baseman, Daniel; Patel, Shilpen; Demandante, Carlo G. N.; Harris, Anna M.; Smith, Benjamin D.; Katz, Alan W.; McGann, Camille; Harper, Jennifer L.; Chang, Daniel T.; Smalley, Stephen; Marshall, David T.; Goodman, Karyn A.; Papanikolaou, Niko; Kachnic, Lisa A.

    2010-01-01

    Purpose Variation in target volume delineation represents a significant hurdle in clinical trials involving conformal radiotherapy. We sought to determine the impact of a consensus guideline-based visual atlas on contouring of target volumes. Methods A representative case and target volume delineation instructions derived from a proposed rectal cancer clinical trial involving conformal radiotherapy were contoured (Scan1) by 14 physician observers and a reference expert. Gross tumor volume (GTV), and 2 clinical target volumes (CTVA, comprising internal iliac, pre-sacral, and peri-rectal nodes, and CTVB, external iliac nodes) were contoured. Observers were randomly assigned to receipt (Group_A) /non-receipt (Group_B) of a consensus guideline and atlas for anorectal cancers, then instructed to re-contour the same case/images (Scan2). Observer variation was analyzed volumetrically using conformation number (CN, where CN=1 equals a total agreement). Results In 14 evaluable contour sets (1 expert, 7 Group_A, 6 Group_B), there was greater agreement for GTV (mean CN 0.75) than CTVs (mean CN 0.46–0.65). Atlas exposure for Group_A led to a significant increased inter-observer agreement for CTVA (mean initial CN 0.68, post-atlas 0.76; p=0.03), as well as increased agreement with the expert reference (initial mean CN 0.58, 0.69 post-atlas; p=0.02). For GTV and CTVB, neither inter-observer nor expert agreement was altered after atlas exposure. Conclusion Consensus guideline atlas implementation resulted in a detectable difference in inter-observer agreement and greater approximation of expert volumes for CTVA, but not GTV or CTVB, in the specified case. Visual atlas inclusion should be considered as a feature in future clinical trials incorporating conformal radiotherapy. PMID:20400244

  17. Efficacy and safety of valproic acid versus haloperidol in patients with acute agitation: results of a randomized, double-blind, parallel-group trial.

    Science.gov (United States)

    Asadollahi, Shadi; Heidari, Kamran; Hatamabadi, Hamidreza; Vafaee, Reza; Yunesian, Somayeh; Azadbakht, Alireza; Mirmohseni, Ladan

    2015-05-01

    The objective of this study was to compare the efficacy of valproate versus haloperidol in decreasing the agitation level in affected patients in the emergency department. We assigned 80 acutely agitated patients to receive either intravenous sodium valproate (20 mg/kg) or intramuscular haloperidol (5 mg/1 ml). Agitation was measured at baseline and 30 min after the first injection using the Agitation-Calmness Evaluation Scale (ACES), the Positive and Negative Syndrome Scale-Excited Component subscale, and the Agitated Behavior Scale. For 80 patients treated with sodium valproate, the mean ± SD dosage was 1541.5 ± 286 mg (range 940-2400). The mean postintervention ACES scores from baseline to 30 min after drug injection were 4.73 (SD = 1.93) for the valproate group and 5.45 (SD = 2.09) for the haloperidol group (P = 0.028). No significant differences were observed in terms of the mean changes 30 min after the intervention for two additional agitation scales. A larger proportion of patients in the haloperidol group experienced intense sedation (36.2%, P haloperidol in reducing agitation, with a better safety profile.

  18. Dynamical creation of complex vector solitons in spinor Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Xiong Bo; Gong Jiangbin

    2010-01-01

    By numerical simulations of the Gross-Pitaevskii mean-field equations, we show that the dynamical creation of stable complex vector solitons in a homogeneous spin-1 Bose-Einstein condensate can be achieved by applying a localized magnetic field for a certain duration, with the initial uniform density prepared differently for the formation of different vector solitons. In particular, it is shown that stable dark-bright-dark vector solitons, dark-bright-bright vector solitons, and other analogous solutions can be dynamically created. It is also found that the peak intensity and the group velocity of the vector solitons thus generated can be tuned by adjusting the applied magnetic field. Extensions of our approach also allow for the creation of vector-soliton chains or the pumping of many vector solitons. The results can be useful for possible vector-soliton-based applications of dilute Bose-Einstein condensates.

  19. Untwisting the pure spinor formalism to the RNS and twistor string in a flat and AdS{sub 5}×S{sup 5} background

    Energy Technology Data Exchange (ETDEWEB)

    Berkovits, Nathan [ICTP South American Institute for Fundamental Research,Instituto de Física Teórica, UNESP - Universidade Estadual Paulista,Rua Dr. Bento T. Ferraz 271, 01140-070, São Paulo, SP (Brazil)

    2016-06-21

    The pure spinor formalism for the superstring can be formulated as a twisted N=2 worldsheet theory with fermionic generators j{sub BRST} and composite b ghost. After untwisting the formalism to an N=1 worldsheet theory with fermionic stress tensor j{sub BRST}+b, the worldsheet variables combine into N=1 worldsheet superfields X{sup m} and Θ{sup α} together with a superfield constraint relating DX{sup m} and DΘ{sup α}. The constraint implies that the worldsheet superpartner of θ{sup α} is a bosonic twistor variable, and different solutions of the constraint give rise to the pure spinor or extended RNS formalisms, as well as a new twistor-string formalism with manifest N=1 worldsheet supersymmetry. These N=1 worldsheet methods generalize in curved Ramond-Ramond backgrounds, and a manifestly N=1 worldsheet supersymmetric action is proposed for the superstring in an AdS{sub 5}×S{sup 5} background in terms of the twistor superfields. This AdS{sub 5}×S{sup 5} worldsheet action is a remarkably simple fermionic coset model with manifest PSU(2,2|4) symmetry and might be useful for computing AdS{sub 5}×S{sup 5} superstring scattering amplitudes.

  20. Post-hoc analysis of MCI186-17, the extension study to MCI186-16, the confirmatory double-blind, parallel-group, placebo-controlled study of edaravone in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Takahashi, Fumihiro; Takei, Koji; Tsuda, Kikumi; Palumbo, Joseph

    2017-10-01

    In the 24-week double-blind study of edaravone in ALS (MCI186-16), edaravone did not show a statistically significant difference versus placebo for the primary efficacy endpoint. For post-hoc analyses, two subpopulations were identified in which edaravone might be expected to show efficacy: the efficacy-expected subpopulation (EESP), defined by scores of ≥2 points on all 12 items of the ALS Functional Rating Scale-Revised (ALSFRS-R) and a percent predicted forced vital capacity (%FVC) ≥80% at baseline; and the definite/probable EESP 2 years (dpEESP2y) subpopulation which, in addition to EESP criteria, had definite or probable ALS diagnosed by El Escorial revised criteria, and disease duration of ≤2 years. In the 36-week extension study of MCI186-16, a 24-week double-blind comparison followed by 12 weeks of open-label edaravone (MCI186-17; NCT00424463), analyses of ALSFRS-R scores of the edaravone-edaravone group and edaravone-placebo group for the full analysis set (FAS) and EESP, as prospectively defined, were reported in a previous article. Here we additionally report results in patients who met dpEESP2y criteria at the baseline of MCI186-16. In the dpEESP2y, the difference in ALSFRS-R changes from 24 to 48 weeks between the edaravone-edaravone and edaravone-placebo groups was 2.79 (p = 0.0719), which was greater than the differences previously reported for the EESP and the FAS. The pattern of adverse events in the dpEESP2y did not show any additional safety findings to those from the earlier prospective study. In conclusion, this post-hoc analysis suggests a potential effect of edaravone between 24 and 48 weeks in patients meeting dpEESP2y criteria at baseline.

  1. The formalism of Lie groups

    Energy Technology Data Exchange (ETDEWEB)

    Salam, A. [Imperial College of Science and Technology, London (United Kingdom)

    1963-01-15

    Throughout the history of quantum theory, a battle has raged between the amateurs and professional group theorists. The amateurs have maintained that everything one needs in the theory of groups can be discovered by the light of nature provided one knows how to multiply two matrices. In support of this claim, they of course, justifiably, point to the successes of that prince of amateurs in this field, Dirac, particularly with the spinor representations of the Lorentz group. As an amateur myself, I strongly believe in the truth of the non-professionalist creed. I think perhaps there is not much one has to learn in the way of methodology from the group theorists except caution. But this does not mean one should not be aware of the riches which have been amassed over the course of years particularly in that most highly developed of all mathematical disciplines - the theory of Lie groups. My lectures then are an amateur's attempt to gather some of the fascinating results for compact simple Lie groups which are likely to be of physical interest. I shall state theorems; and with a physicist's typical unconcern rarely, if ever, shall I prove these. Throughout, the emphasis will be to show the close similarity of these general groups with that most familiar of all groups, the group of rotations in three dimensions.

  2. Double Chooz

    Energy Technology Data Exchange (ETDEWEB)

    Buck, Christian [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany)

    2006-05-15

    The goal of the Double Chooz reactor neutrino experiment is to search for the neutrino mixing parameter {theta}{sub 13}. Double Chooz will use two identical detectors at 150 m and 1.05 km distance from the reactor cores. The near detector is used to monitor the reactor {nu}-bar {sub e} flux while the second is dedicated to the search for a deviation from the expected (1/distance){sup 2} behavior. This two detector concept will allow a relative normalization systematic error of ca. 0.6 %. The expected sensitivity for sin{sup 2}2{theta}{sub 13} is then in the range 0.02 - 0.03 after three years of data taking. The antineutrinos will be detected in a liquid scintillator through the capture on protons followed by a gamma cascade, produced by the neutron capture on Gd.

  3. Double ambidexterity

    DEFF Research Database (Denmark)

    Kaulio, Matti; Thorén, Kent; Rohrbeck, René

    2017-01-01

    We leverage the business model innovation and ambidexterity literature to investigate a contradictory case, the Swedish-Finnish Telecom operator TeliaSonera. Despite being challenged by three major disruptions, the company not only still exists but also enjoys remarkably good financial performance....... Building on extant archival data and interviews, we carefully identify and map 26 organizational responses during 1992–2016. We find that the firm has overcome three critical phases by experimenting and pioneering with portfolios of business models and/or technological innovations. We describe...... this behaviour as double ambidexterity. We use an in-depth case study to conceptualize double ambidexterity and discuss its impact on the business's survival and enduring success....

  4. Spinor analysis of the Yang-Mills theory in the Minkowski space

    International Nuclear Information System (INIS)

    Pervushin, V.N.; Horejsi, J.

    1982-01-01

    Spinorial methods are applied to the solution of self-duality equations for Yang-Mills field and the Dirac equation with an external self-dual field in the Minkowski space. Gauge group SU(2) is considered. It is shown that in the spinorial formalism an analog of the Yang construction of self-dual fields emerges naturally. Solutions of the Dirac eqUation for massless fermion with an arbitrary isospin, interacting with an external self-dual or anti-self-dual field are obtained. The external field is chosen to be the Minkowskian analog of the EUclidean Hooft Ansatz. It is shown that for the isospin 1/2 and 1 the solutions of the Dirac equation may be expressed in terms of the solutions of d'Alembert equation. The solutions obtained may be employed in the approach to gauge theories proposed recently, which is based on an analogy with the superfluidity theory; in such an approach the self-dual solutions of the Yang-Mills equations represent the vacuum

  5. Effects of Corrective Exercise for Thoracic Hyperkyphosis on Posture, Balance, and Well-Being in Older Women: A Double-Blind, Group-Matched Design.

    Science.gov (United States)

    Jang, Hyun-Jeong; Hughes, Lynne C; Oh, Duck-Won; Kim, Suhn-Yeop

    2017-09-13

    The purpose of this study was to identify the effects of a corrective exercise for thoracic hyperkyphosis on posture, balance, and well-being in Korean community-dwelling older women. Fifty women 65 years of age and older, recruited from 2 senior centers, participated in this study. Participants were assigned to either the experimental group (EG) or the control group (CG) on the basis of convenience of location, and 22 in each were analyzed. Participants in the EG underwent a thoracic corrective exercise program 1 hour each session, twice per week for 8 weeks (a total of 16 sessions), which consisted of specific exercises to enhance breathing, thoracic mobility and stability, and awareness of thoracic alignment. The CG received education on the same thoracic corrective exercise program and a booklet of the exercises. Outcome measures included the extent of postural abnormality (angle of thoracic kyphosis, kyphosis index calculated both in relaxed- and best posture using flexicurve, the ratio of the kyphosis index calculated best posture/relaxed posture, craniovertebral angle, and tragus-to-wall distance), balance (Short Physical Performance Battery and limit of stability), and well-being (Geriatric Depression Scale Short Form and the 36-Item Short Form Health Survey [SF-36]). All data were collected by 6 blinded assessors at baseline, at 8 weeks after the completion of intervention, and at 16 weeks for follow-up. For participants of the EG, means of all parameters showed significant improvements over time (P posture, balance, and well-being in older women with thoracic hyperkyphosis. We recommend the use of the therapeutic strategies utilized in this study to enhance thoracic posture, balance, and well-being of older women with thoracic hyperkyphosis. Future research is needed to apply this exercise protocol on a larger and more diverse population.

  6. Double role of the hydroxy group of phosphoryl in palladium(II)-catalyzed ortho-olefination: a combined experimental and theoretical investigation.

    Science.gov (United States)

    Liu, Liu; Yuan, Hang; Fu, Tingting; Wang, Tao; Gao, Xiang; Zeng, Zhiping; Zhu, Jun; Zhao, Yufen

    2014-01-03

    Density functional theory calculations have been carried out on Pd-catalyzed phosphoryl-directed ortho-olefination to probe the origin of the significant reactivity difference between methyl hydrogen benzylphosphonates and dimethyl benzylphosphonates. The overall catalytic cycle is found to include four basic steps: C-H bond activation, transmetalation, reductive elimination, and recycling of catalyst, each of which is constituted from different steps. Our calculations reveal that the hydroxy group of phosphoryl plays a crucial role almost in all steps, which can not only stabilize the intermediates and transition states by intramolecular hydrogen bonds but also act as a proton donor so that the η(1)-CH3COO(-) ligand could be protonated to form a neutral acetic acid for easy removal. These findings explain why only the methyl hydrogen benzylphosphonates and methyl hydrogen phenylphosphates were found to be suitable reaction partners. Our mechanistic findings are further supported by theoretical prediction of Pd-catalyzed ortho-olefination using methyl hydrogen phenylphosphonate, which is verified by experimental observations that the desired product was formed in a moderate yield.

  7. Multicenter, double-blind, parallel group study investigating the non-inferiority of efficacy and safety of a 2% miconazole nitrate shampoo in comparison with a 2% ketoconazole shampoo in the treatment of seborrhoeic dermatitis of the scalp.

    Science.gov (United States)

    Buechner, Stanislaw A

    2014-06-01

    This study investigated the non-inferiority of efficacy and tolerance of 2% miconazole nitrate shampoo in comparison with 2% ketoconazole shampoo in the treatment of scalp seborrheic dermatitis. A randomized, double-blind, comparative, parallel group, multicenter study was done. A total of 274 patients (145 miconazole, 129 ketoconazole) were enrolled. Treatment was twice-weekly for 4 weeks. Safety and efficacy assessments were made at baseline and at weeks 2 and 4. Assessments included symptoms of erythema, itching, scaling ['Symptom Scale of Seborrhoeic Dermatitis' (SSSD)], disease severity and global change [Clinical Global Impressions (CGIs) and Patient Global Impressions (PGIs)]. Miconazole shampoo is at least as effective and safe as ketoconazole shampoo in treating scalp seborrheic dermatitis scalp.

  8. A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis.

    Science.gov (United States)

    Irving, Peter M; Iqbal, Tariq; Nwokolo, Chuka; Subramanian, Sreedhar; Bloom, Stuart; Prasad, Neeraj; Hart, Ailsa; Murray, Charles; Lindsay, James O; Taylor, Adam; Barron, Rachel; Wright, Stephen

    2018-03-19

    Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve disease activity in inflammatory bowel disease. This proof-of-concept study assessed efficacy, safety and tolerability of CBD-rich botanical extract in ulcerative colitis (UC) patients. Patients aged 18 years or older, with left-sided or extensive UC, Mayo scores of 4-10 (endoscopy scores ≥1), and on stable 5-aminosalicylic acid dosing, were randomized to 10-weeks' CBD-rich botanical extract or placebo capsules. The primary endpoint was the percentage of patients in remission after treatment. Statistical testing was 2-sided, using a 10% significance level. Patients were less tolerant of CBD-rich botanical extract compared with placebo, taking on average one-third fewer capsules, and having more compliance-related protocol deviations (principally insufficient exposure), prompting identification of a per protocol (PP) analysis set. The primary endpoint was negative; end of treatment remission rates were similar for CBD-rich botanical extract (28%) and placebo (26%). However, PP analysis of total and partial Mayo scores favoured CBD-rich botanical extract (P = 0.068 and P = 0.038, respectively). Additionally, PP analyses of the more subjective physician's global assessment of illness severity, subject global impression of change, and patient-reported quality-of-life outcomes were improved for patients taking CBD-rich botanical extract (P = 0.069, P = 0.003, and P = 0.065, respectively). Adverse events (AEs) were predominantly mild/moderate with many in the CBD-rich botanical extract group potentially attributable to the ∆9-tetrahydrocannabinol content. A greater proportion of gastrointestinal-related AEs, indicative of UC worsening, was seen on placebo. Although the primary endpoint was not reached, several signals suggest CBD-rich botanical extract may be beneficial for symptomatic treatment of UC.

  9. Efficacy of treatment of insomnia in migraineurs with eszopiclone (Lunesta®) and its effect on total sleep time, headache frequency, and daytime functioning: A randomized, double-blind, placebo-controlled, parallel-group, pilot study.

    Science.gov (United States)

    Spierings, Egilius L H; McAllister, Peter J; Bilchik, Tanya R

    2015-04-01

    A review on headache and insomnia revealed that insomnia is a risk factor for increased headache frequency and headache intensity in migraineurs. The authors designed a randomized, double blind, placebo-controlled, parallel-group, pilot study in which migraineurs who also had insomnia were enrolled, to test this observation. In the study, the authors treated 79 subjects with IHS-II migraine with and/or without aura and with DSM-IV primary insomnia for 6 weeks with 3 mg eszopiclone (Lunesta(®)) or placebo at bedtime. The treatment was preceded by a 2-week baseline period and followed by a 2-week run-out period. Of the 79 subjects treated, 75 were evaluable, 35 in the eszopiclone group, and 40 in the placebo group. At baseline, the groups were comparable except for sleep latency. Of the three remaining sleep variables, total sleep time, nighttime awakenings, and sleep quality, the number of nighttime awakenings during the 6-week treatment period was significantly lower in the eszopiclone group than in the placebo group (P = 0.03). Of the three daytime variables, alertness, fatigue, and functioning, this was also the case for fatigue (P = 005). The headache variables, frequency, duration, and intensity, did not show a difference from placebo during the 6-week treatment period. The study did not meet primary endpoint, that is, the difference in total sleep time during the 6-week treatment period between eszopiclone and placebo was less than 40 minutes. Therefore, it failed to answer the question as to whether insomnia is, indeed, a risk factor for increased headache frequency and headache intensity in migraineurs.

  10. Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication.

    Science.gov (United States)

    Kawashima, Makoto; Sato, Shinichi; Furukawa, Fukumi; Matsunaga, Kayoko; Akamatsu, Hirohiko; Igarashi, Atsuyuki; Tsunemi, Yuichiro; Hayashi, Nobukazu; Yamamoto, Yuki; Nagare, Toshitaka; Katsuramaki, Tsuneo

    2017-07-01

    A placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study was conducted to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris. Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. All 609 subjects were randomly assigned to receive the study products (2.5% and 5% BPO and placebo), and 607 subjects were included in the full analysis set, 544 in the per protocol set and 609 in the safety analyses. The median rates of reduction from baseline to the last evaluation of the inflammatory lesion counts, the primary end-point, in the 2.5% and 5% BPO groups were 72.7% and 75.0%, respectively, and were significantly higher than that in the placebo group (41.7%). No deaths or other serious adverse events were observed. The incidences of adverse events in the 2.5% and 5% BPO groups were 56.4% and 58.8%, respectively; a higher incidence than in the placebo group, but there was no obvious difference between the 2.5% and 5% BPO groups. All adverse events were mild or moderate in severity. Most adverse events did not lead to study product discontinuation. The results suggested that both 2.5% and 5% BPO are useful for the treatment of acne vulgaris. © 2017 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd.

  11. An electron diffraction and bond valence sum study of the space group symmetries and structures of the photocatalytic 1:1 ordered A2InNbO6 double perovskites (A=Ca2+, Sr2+, Ba2+)

    International Nuclear Information System (INIS)

    Ting, V.; Liu, Y.; Withers, R.L.; Krausz, E.

    2004-01-01

    A careful investigation has been carried out into the space group symmetries, structures and crystal chemistries of the 1:1 B-site ordered double perovskites A 2 InNbO 6 (A=Ca 2+ , Sr 2+ , Ba 2+ ) using a combination of bond valence sum calculations, powder XRD and electron diffraction. A recent investigation of these compounds by Yin et al. reported a random distribution of In 3+ and Nb 5+ ions onto the perovskite B-site positions of these compounds and hence Pm3-barm (a=a p , subscript p for parent perovskite sub-structure) space group symmetry for the A=Ba and Sr compounds and Pnma (a=a p +b p , b=-a p +b p , c=2c p ) space group symmetry for the A=Ca compound. A careful electron diffraction study, however, shows that both the A=Ca and Sr compounds occur at room temperature in P12 1 /n1 (a=a p +b p , b=-a p +b p , c=2c p ) perovskite-related superstructure phases while the A=Ba compound occurs in the Fm3-barm, a=2a p , elpasolite structure type. Bond valence sum calculations are used to explain why this should be so as well as to provide a useful first-order approximation to the structures of each of the compounds

  12. Intralesional immunotherapy with tuberculin purified protein derivative (PPD) in recalcitrant wart: A randomized, placebo-controlled, double-blind clinical trial including an extra group of candidates for cryotherapy.

    Science.gov (United States)

    Amirnia, Mehdi; Khodaeiani, Effat; Fouladi, Daniel F; Masoudnia, Sima

    2016-01-01

    Due to paucity of randomized clinical trials, intralesional immunotherapy has not been yet accepted as a standard therapeutic method. To examine the efficacy and safety of intralesional immunotherapy with tuberculin purified protein derivative (PPD) for treating recalcitrant wart. In this randomized, placebo-controlled, double-blind clinical trial, a total of 69 patients with recalcitrant warts received either intralesional PPD antigen (n = 35) or intralesional saline (n = 34) for six times at 2-week intervals. A third group of candidates for cryotherapy (n = 33) was also included. The decrease in lesion size (good: complete response, intermediate: 50-99% improvement, poor: PPD patients; 0%, 14.7% and 85.3% of the placebo patients and 18.2%, 33.3% and 48.5% of the cryotherapy patients, respectively (PPD versus placebo: p PPD versus cryotherapy: p PPD group. The recurrence rate was 8.6%, 5.9% and 24.2% in the PPD, placebo and cryotherapy groups, respectively (p > 0.05). Intralesional immunotherapy with PPD antigen is highly effective and safe for treating recalcitrant warts. IRCT201407089844N3 in the Iranian Registry of Clinical Trials (IRCT).

  13. Exploratory double-blind, parallel-group, placebo-controlled study of edaravone (MCI-186) in amyotrophic lateral sclerosis (Japan ALS severity classification: Grade 3, requiring assistance for eating, excretion or ambulation).

    Science.gov (United States)

    2017-10-01

    Our objective was to explore the efficacy and safety of edaravone in amyotrophic lateral sclerosis (ALS) patients with a Japan ALS severity classification of Grade 3. In a 24-week, double-blind, randomized study, 25 patients who met all of the following criteria were enrolled: Japan ALS severity classification Grade 3; definite, probable, or probable-laboratory supported ALS (El Escorial/revised Airlie House); forced vital capacity (%FVC) ≥60%; duration of disease ≤3 years at consent; and change in the revised ALS functional rating scale (ALSFRS-R) score of -1 to -4 points during the 12-week pre-observation period. Patients received edaravone (n = 13) or placebo (n = 12) for six cycles. The efficacy outcome was change in the ALSFRS-R score. The least-squares mean change in the ALSFRS-R score ± standard error during the 24-week treatment was -6.52 ± 1.78 in the edaravone group and -6.00 ± 1.83 in the placebo group; the difference of -0.52 ± 2.46 was not statistically significant (p = 0.835). Incidence of adverse events was 92.3% (12/13) in the edaravone group and 100.0% (12/12) in the placebo group. There was no intergroup difference in the changes in the ALSFRS-R score. The incidences of adverse events were similar in the two groups.

  14. Clifford numbers and spinors

    CERN Document Server

    Lounesto, Pertti

    1993-01-01

    This volume contains a facsimile reproduction of Marcel Riesz's notes of a set of lectures he delivered at the University of Maryland, College Park, between October 1957 and January 1958, which has not been formally published to date This seminal material (arranged in four chapters), which contributed greatly to the start of modern research on Clifford algebras, is supplemented in this book by notes which Riesz dictated to E Folke Bolinder in the following year and which were intended to be a fifth chapter of the Riesz lecture notes In addition, Riesz's work on Clifford algebra is put into an historical perspective in a separate review by P Lounesto As well as providing an introduction to Clifford algebra, this volume will be of value to those interested in the history of mathematics

  15. A Paired, Double-Blind, Randomized Comparison of a Moisturizing Durable Barrier Cream to 10% Glycerine Cream in the Prophylactic Management of Postmastectomy Irradiation Skin Care: Trans Tasman Radiation Oncology Group (TROG) 04.01

    Energy Technology Data Exchange (ETDEWEB)

    Graham, Peter H., E-mail: peter.graham@sesiahs.health.nsw.gov.au [Cancer Care Centre, St. George Hospital, Kogarah, New South Wales (Australia); Plant, Natalie; Graham, Jennifer L.; Browne, Lois [Cancer Care Centre, St. George Hospital, Kogarah, New South Wales (Australia); Borg, Martin [Department of Radiation Oncology, Royal Adelaide Hospital (Australia); Capp, Anne [Department of Radiation Oncology, Mater Hospital, Newcastle, New South Wales (Australia); Delaney, Geoff P. [Cancer Care Centre, Liverpool Hospital, Liverpool, New South Wales (Australia); Harvey, Jennifer [Mater Hospital, South Brisbane, Queensland (Australia); Kenny, Lisbeth [Royal Brisbane Hospital, Herston, Queensland (Australia); Francis, Michael [Andrew Love Cancer Centre, Geelong (Australia); Zissiadis, Yvonne [Department of Radiation Oncology, Royal Perth Hospital, Perth (Australia)

    2013-05-01

    Purpose: A previous, unblinded study demonstrated that an alcohol-free barrier film containing an acrylate terpolymer (ATP) was effective in reducing skin reactions compared with a 10% glycerine cream (sorbolene). The different appearances of these products precluded a blinded comparison. To test the acrylate terpolymer principle in a double-blinded manner required the use of an alternative cream formulation, a moisturizing durable barrier cream (MDBC); the study was conducted by the Trans Tasman Radiation Oncology Group (TROG) as protocol 04.01. Methods and Materials: A total of 333 patients were randomized; 1 patient was ineligible and 14 patients withdrew or had less than 7 weeks' observations, leaving 318 for analysis. The chest wall was divided into medial and lateral compartments, and patients were randomized to have MDBC applied daily to the medial or lateral compartment and sorbolene to the other compartment. Weekly observations, photographs, and symptom scores (pain and pruritus) were collected to week 12 or resolution of skin reactions if earlier. Skin dose was confirmed by centrally calibrated thermoluminescent dosimeters. Results: Rates of medial and lateral compartment Common Toxicity Criteria (CTC), version 3, greater than or equal to grade 3 skin reactions were 23% and 41%, but rates by skin care product were identical at 32%. There was no significant difference between MDBC and sorbolene in the primary endpoint of peak skin reactions or secondary endpoints of area-under-the-curve skin reaction scores. Conclusions: The MDBC did not reduce the peak skin reaction compared to sorbolene. It is possible that this is related to the difference in the formulation of the cream compared with the film formulation. Skin dosimetry verification and double blinding are essential for radiation skin care comparative studies.

  16. A Paired, Double-Blind, Randomized Comparison of a Moisturizing Durable Barrier Cream to 10% Glycerine Cream in the Prophylactic Management of Postmastectomy Irradiation Skin Care: Trans Tasman Radiation Oncology Group (TROG) 04.01

    International Nuclear Information System (INIS)

    Graham, Peter H.; Plant, Natalie; Graham, Jennifer L.; Browne, Lois; Borg, Martin; Capp, Anne; Delaney, Geoff P.; Harvey, Jennifer; Kenny, Lisbeth; Francis, Michael; Zissiadis, Yvonne

    2013-01-01

    Purpose: A previous, unblinded study demonstrated that an alcohol-free barrier film containing an acrylate terpolymer (ATP) was effective in reducing skin reactions compared with a 10% glycerine cream (sorbolene). The different appearances of these products precluded a blinded comparison. To test the acrylate terpolymer principle in a double-blinded manner required the use of an alternative cream formulation, a moisturizing durable barrier cream (MDBC); the study was conducted by the Trans Tasman Radiation Oncology Group (TROG) as protocol 04.01. Methods and Materials: A total of 333 patients were randomized; 1 patient was ineligible and 14 patients withdrew or had less than 7 weeks' observations, leaving 318 for analysis. The chest wall was divided into medial and lateral compartments, and patients were randomized to have MDBC applied daily to the medial or lateral compartment and sorbolene to the other compartment. Weekly observations, photographs, and symptom scores (pain and pruritus) were collected to week 12 or resolution of skin reactions if earlier. Skin dose was confirmed by centrally calibrated thermoluminescent dosimeters. Results: Rates of medial and lateral compartment Common Toxicity Criteria (CTC), version 3, greater than or equal to grade 3 skin reactions were 23% and 41%, but rates by skin care product were identical at 32%. There was no significant difference between MDBC and sorbolene in the primary endpoint of peak skin reactions or secondary endpoints of area-under-the-curve skin reaction scores. Conclusions: The MDBC did not reduce the peak skin reaction compared to sorbolene. It is possible that this is related to the difference in the formulation of the cream compared with the film formulation. Skin dosimetry verification and double blinding are essential for radiation skin care comparative studies

  17. Analyzing Double Image Illusion through Double Indiscernibility and Lattice Theory

    Directory of Open Access Journals (Sweden)

    Kohei Sonoda

    2011-10-01

    Full Text Available The figure-ground division plays a fundamental role in all image perceptions. Although there are a lot of studies about extraction of a figure such as detection of edges or grouping of texture, there are few discussions about a relationship between obtained figure and ground. We focused on double image illusions having two complementary relationships be- tween figure and ground and analyzed them. We divided the double image illusions according to two different interpretations and using these divisions we extracted and analyzed their logical structures by lattices derived from rough sets that we had developed. As a result we discovered unusual logical structures in double image illusions.

  18. Effects on hemodynamics and gas exchange of omega-3 fatty acid-enriched lipid emulsion in acute respiratory distress syndrome (ARDS: a prospective, randomized, double-blind, parallel group study

    Directory of Open Access Journals (Sweden)

    Sacanell Judit

    2008-10-01

    Full Text Available Abstract Introduction We investigated the effects on hemodynamics and gas exchange of a lipid emulsion enriched with omega-3 fatty acids in patients with ARDS. Methods The design was a prospective, randomized, double-blind, parallel group study in our Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain. We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men and 2 women; mean age: 58 ± 13 years; APACHE II score: 17.8 ± 2.3; Lung Injury Score: 3.1 ± 0.5; baseline PaO2/FiO2 ratio: 149 ± 40. Patients were randomized into 2 groups: Group A (n = 8 received the study emulsion Lipoplus® 20%, B.Braun Medical (50% MCT, 40% LCT, 10% ω-3; Group B (n = 8 received the control emulsion Intralipid® Fresenius Kabi (100% LCT. Lipid emulsions were administered during 12 h at a dose of 0.12 g/kg/h. Measurements of the main hemodynamic and gas exchange parameters were made at baseline (immediately before administration of the lipid emulsions, every hour during the lipid infusion, at the end of administration, and six hours after the end of administration lipid infusion. Results No statistically significant changes were observed in the different hemodynamic values analyzed. Likewise, the gas exchange parameters did not show statistically significant differences during the study. No adverse effect attributable to the lipid emulsions was seen in the patients analyzed. Conclusion The lipid emulsion enriched with omega-3 fatty acids was safe and well tolerated in short-term administration to patients with ARDS. It did not cause any significant changes in hemodynamic and gas exchange parameters. Trial registration ISRCTN63673813

  19. Prospective, Randomized, Double-Blind, Parallel-Group, Comparative Effectiveness Clinical Trial Comparing a Powder Vehicle Compound of Vitamin D With an Oil Vehicle Compound in Adults With Cystic Fibrosis.

    Science.gov (United States)

    Hermes, Wendy A; Alvarez, Jessica A; Lee, Moon J; Chesdachai, Supavit; Lodin, Daud; Horst, Ron; Tangpricha, Vin

    2017-08-01

    There is little consensus on the most efficacious vehicle substance for vitamin D supplements. Fat malabsorption may impede the ability of patients with cystic fibrosis (CF) to absorb vitamin D in an oil vehicle. We hypothesized that vitamin D contained in a powder vehicle would be absorbed more efficiently than vitamin D contained in an oil vehicle in patients with CF. In this double-blind, randomized controlled trial, hospitalized adults with CF were given a one-time bolus dose of 100,000 IU of cholecalciferol (D 3 ) in a powder-based or oil-based vehicle. Serum D 3 , 25-hydroxyvitamin D, and parathyroid hormone concentrations were analyzed at 0, 12, 24, and 48 hours posttreatment. The area under the curve for serum D 3 and the 12-hour time point were also assessed as indicators of D 3 absorption. This trial was completed by 15 patients with CF. The median (interquartile range) age, body mass index, and forced expiratory volume in 1 second were 23.7 (19.9-33.2) years, 19.9 (18.6-22.6) kg/m 2 , and 63% (37%-80%), respectively. The increase in serum D 3 and the area under the curve was greater in the powder group ( P = .002 and P = .036, respectively). Serum D 3 was higher at 12 hours in the powder group compared with the oil group ( P = .002), although levels were similar between groups by 48 hours. In adults with CF, cholecalciferol is more efficiently absorbed in a powder compared with an oil vehicle. Physicians should consider prescribing vitamin D in a powder vehicle in patients with CF to improve the absorption of vitamin D from supplements.

  20. The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study.

    Science.gov (United States)

    Ghali, Jalal K; Orlandi, Cesare; Abraham, William T

    2012-06-01

    Volume overload is the dominant feature of decompensated heart failure (HF) and it often results in adverse clinical outcomes. Vasopressin receptor antagonists such as lixivaptan may provide effective volume unloading. This study assessed weight loss after 1 day and 8 weeks of treatment with lixivaptan in outpatients with HF and volume overload. This phase II, 8-week, multicentre, double-blind, parallel-group study randomized participants (2:1) to receive lixivaptan 100 mg or placebo once daily (in addition to standard HF therapy). Body weight and cardiovascular assessments were made at baseline, Day 1 (not cardiovascular), Weeks 1, 2, 4, and 8, and 7 days post-treatment. The Trail-making Test, part B (TMT-B) and the Medical Outcomes Survey 6-item cognitive function scale (MOS-6) were assessed at baseline and Week 4. The study randomized 170 participants (lixivaptan, n = 111; placebo, n = 59). Most (97.1%) were receiving pharmacological therapy for HF at baseline. Demographic characteristics were generally similar between the two groups. Body weight decreased significantly from baseline to Day 1 with lixivaptan vs. placebo (least-square mean change ± standard error: - 0.38 ± 0.08 kg vs. +0.13 ± 0.11 kg; P overload, lixivaptan 100 mg once daily, when added to standard therapy, reduced body weight, improved dyspnoea and orthopnoea, and was well tolerated. NCT01055912.

  1. A Herbal Medicine, Gongjindan, in Subjects with Chronic Dizziness (GOODNESS Study: Study Protocol for a Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Clinical Trial for Effectiveness, Safety, and Cost-Effectiveness

    Directory of Open Access Journals (Sweden)

    Seungwon Shin

    2017-01-01

    Full Text Available This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication, Gongjindan (GJD, in patients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight patients diagnosed with Meniere’s disease, psychogenic dizziness, or dizziness of unknown cause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g GJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory score. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale and frequency of dizziness, balance function (Berg Balance Scale, fatigue (Fatigue Severity Scale and deficiency pattern/syndrome (qi blood yin yang-deficiency questionnaire levels, and depression (Korean version of Beck’s Depression Inventory and anxiety (State-Trait Anxiety Inventory levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the incremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensions’ questionnaire and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided. This trial is registered with ClinicalTrials.gov NCT03219515, in July 2017.

  2. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team.

    Science.gov (United States)

    Chaisson, R E; Benson, C A; Dube, M P; Heifets, L B; Korvick, J A; Elkin, S; Smith, T; Craft, J C; Sattler, F R

    1994-12-15

    To determine the antimicrobial activity and tolerability of clarithromycin for treating bacteremic Mycobacterium avium complex disease in patients with the acquired immunodeficiency syndrome (AIDS). A randomized, double-blind, dose-ranging study. Outpatient clinics. 154 patients with human immunodeficiency virus (HIV) infection and blood cultures positive for M. avium complex who had symptomatic disease. Random assignment to clarithromycin at dosages of 500 mg, 1000 mg, or 2000 mg twice daily for 12 weeks. Median number of colony-forming units of M. avium complex per milliliter of blood. Clarithromycin decreased mycobacterial CFUs from 2.7 to 2.8 log 10/mL of blood at baseline to less than 0 log 10/mL during follow-up (P groups. Clarithromycin-resistant isolates of M. avium complex developed in 46% of patients at a median of 16 weeks. Median survival was longer in patients assigned to 500 mg twice daily (median, 249 days) than in patients assigned to 1000 mg or 2000 mg. Death in the first 12 weeks was lowest in the 500-mg group (P = 0.007). Clarithromycin therapy acutely decreased M. avium complex bacteremia in patients with HIV infection by more than 99%. Clarithromycin, 500 mg twice daily, was well tolerated and associated with better survival. Emergence of clarithromycin-resistant organisms was an important problem.

  3. A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face.

    Science.gov (United States)

    Gupta, Aditya K; Lynde, Charles W; Kunynetz, Rod A W; Amin, Smita; Choi, Ken; Goldstein, Eric

    2003-01-01

    Combination treatments for acne vulgaris, such as Benzamycin (3% erythromycin/5% benzoyl peroxide) and Stievamycin (0.025% tretinoin/erythromycin 4%), reduce bacterial growth, which contributes to the inflammatory lesions typical of adolescent acne, and also decrease the epidermal cell compaction which may form the characteristic noninflammatory comedone. Both agents contain erythromycin to reduce the growth of Propionibacterium acnes in skin. Benzoyl peroxide has antibiotic activity as well as anticomedogenic properties. Tretinoin may increase the turnover of epidermal cells and loosen the cells compacted to form comedones. A combination preparation containing the two antibiotics may reduce the development of resistance; the combination preparation containing tretinoin and erythromycin will have an antibiotic effect as well as acting on differentiation. This multicenter, randomized, double-blind, parallel group study compared the effectiveness of 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4%, each applied twice daily in patients with moderate acne vulgaris. Overall physician and patient ratings of severity of acne symptoms were performed at baseline and at weeks 2, 4, 8, and 12. At baseline the two treatment groups had similar disease severity. The number of papules, pustules, and comedones was reduced in both treatment groups at week 12, and the reductions were not significantly different between the two comparators. Global physician rating of improvement was significantly higher in the 3% erythromycin/5% benzoyl peroxide group compared with the 0.025% tretinoin/erythromycin 4% group; however, there was no significant difference in global patient ratings between the two treatment groups. An aggregate score was produced, for both physician rating and patient rating, by adding up individual symptom severity ratings. Compared with 0.025% tretinoin/erythromycin 4%, 3% erythromycin/5% benzoyl peroxide provided significantly greater reduction

  4. Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS: A prospective, randomized, double-blind, parallel group study

    Directory of Open Access Journals (Sweden)

    Chacon Pilar

    2011-04-01

    Full Text Available Abstract Background The use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. The type and quantity of the lipid emulsions used could modulate this response, which is mediated by the eicosanoids. This study investigates the use of omega-3 fatty acid-enriched lipid emulsions in ARDS patients and their effects on eicosanoid values. Methods Prospective, randomized, double-blind, parallel group study carried out at the Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain. We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men; age: 58 ± 13 years; APACHE II score 17.8 ± 2.3; Lung Injury Score: 3.1 ± 0.5; baseline PaO2/FiO2 ratio: 149 ± 40. Patients were randomized into two groups: Group A (n = 8 received the study emulsion Lipoplus® 20%, B. Braun Medical (50% MCT, 40% LCT, 10% fish oil (FO; Group B (n = 8 received the control emulsion Intralipid® Fresenius Kabi (100% LCT. Lipid emulsions were administered for 12 h at a dose of 0.12 g/kg/h. We measured LTB4, TXB2, and 6-keto prostaglandin F1α values at baseline [immediately before the administration of the lipid emulsions (T-0], at the end of the administration (T-12 and 24 hours after the beginning of the infusion (T 24 in arterial and mixed venous blood samples. Results In group A (FO LTB4, TXB2, 6-keto prostaglandin F1α levels fell during omega-3 administration (T12. After discontinuation (T24, levels of inflammatory markers (both systemic and pulmonary behaved erratically. In group B (LCT all systemic and pulmonary mediators increased during lipid administration and returned to baseline levels after discontinuation, but the differences did not reach statistical significance. There was a clear interaction between the treatment in group A (fish oil and changes in LTB4 over time. Conclusions Infusion of

  5. Randomised, double-blind, placebo-controlled studies on flurbiprofen 8.75 mg lozenges in patients with/without group A or C streptococcal throat infection, with an assessment of clinicians' prediction of 'strep throat'.

    Science.gov (United States)

    Shephard, A; Smith, G; Aspley, S; Schachtel, B P

    2015-01-01

    Diagnosing group A streptococcus (Strep A) throat infection by clinical examination is difficult, and misdiagnosis may lead to inappropriate antibiotic use. Most patients with sore throat seek symptom relief rather than antibiotics, therefore, therapies that relieve symptoms should be recommended to patients. We report two clinical trials on the efficacy and safety of flurbiprofen 8.75 mg lozenge in patients with and without streptococcal sore throat. The studies enrolled adults with moderate-to-severe throat symptoms (sore throat pain, difficulty swallowing and swollen throat) and a diagnosis of pharyngitis. The practitioner assessed the likelihood of Strep A infection based on historical and clinical findings. Patients were randomised to flurbiprofen 8.75 mg or placebo lozenges under double-blind conditions and reported the three throat symptoms at baseline and at regular intervals over 24 h. A total of 402 patients received study medication (n = 203 flurbiprofen, n = 199 placebo). Throat culture identified Strep A in 10.0% of patients and group C streptococcus (Strep C) in a further 14.0%. The practitioners' assessments correctly diagnosed Strep A in 11/40 cases (sensitivity 27.5%, and specificity 79.7%). A single flurbiprofen lozenge provided significantly greater relief than placebo for all three throat symptoms, lasting 3-4 h for patients with and without Strep A/C. Multiple doses of flurbiprofen lozenges over 24 h also led to symptom relief, although not statistically significant in the Strep A/C group. There were no serious adverse events. The results highlight the challenge of identifying Strep A based on clinical features. With the growing problem of antibiotic resistance, non-antibiotic treatments should be considered. As demonstrated here, flurbiprofen 8.75 mg lozenges are an effective therapeutic option, providing immediate and long-lasting symptom relief in patients with and without Strep A/C infection. © 2014 John Wiley & Sons Ltd.

  6. A double-blind, randomized, multiple-dose, parallel-group study to characterize the occurrence of diarrhea following two different dosing regimens of neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor.

    Science.gov (United States)

    Abbas, Richat; Hug, Bruce A; Leister, Cathie; Sonnichsen, Daryl

    2012-07-01

    Neratinib, a potent, low-molecular-weight, orally administered, irreversible, pan-ErbB receptor tyrosine kinase inhibitor has antitumor activity in ErbB2 + breast cancer. The objective of this study was to characterize the onset, severity, and duration of diarrhea after administration of neratinib 240 mg once daily (QD) and 120 mg twice daily (BID) for ≤14 days in healthy subjects. A randomized, double-blind, parallel-group, inpatient study was conducted in 50 subjects given oral neratinib either 240 mg QD or 120 mg BID with food for ≤14 days. The primary endpoint was the proportion of subjects with diarrhea of at least moderate severity (grade 2; 5-7 loose stools/day). In subjects with grade 2 diarrhea, fecal analytes were determined. Pharmacokinetic profiles were characterized for neratinib on Days 1 and 7. No severe (grade 3) diarrhea was reported. By Day 4, all subjects had grade 1 diarrhea. Grade 2 diarrhea occurred in 11/22 evaluable subjects (50 % [90 % confidence interval (CI): 28-72 %]) in the QD group and 17/23 evaluable subjects (74 % [90 % CI: 52-90 %]) in the BID group (P = 0.130). In fecal analyses, 18 % tested positive for hemoglobin and 46 % revealed fecal lactoferrin. Specimen pH was neutral to slightly alkaline. In pharmacokinetic analyses, Day 1 peak plasma concentration and Day 7 steady-state exposure were higher with the QD regimen than the BID regimen. In an exploratory analysis, ABCG2 genotype showed no correlation with severity or onset of diarrhea. Incidences and onsets of at least grade 1 and at least grade 2 diarrhea were not improved on BID dosing compared with QD dosing.

  7. Double inflation

    International Nuclear Information System (INIS)

    Silk, J.; Turner, M.S.

    1986-04-01

    The Zel'dovich spectrum of adiabatic density perturbations is a generic prediction of inflation. There is increasing evidence that when the spectrum is normalized by observational data on small scales, there is not enough power on large scales to account for the observed large-scale structure in the Universe. Decoupling the spectrum on large and small scales could solve this problem. As a means of decoupling the large and small scales we propose double inflation (i.e., two episodes of inflation). In this scenario the spectrum on large scales is determined by the first episode of inflation and those on small scales by a second episode of inflation. We present three models for such a scenario. By nearly saturating the large angular-scale cosmic microwave anisotropy bound, we can easily account for the observed large-scale structure. We take the perturbations on small scales to be very large, deltarho/rho approx. = 0.1 to 0.01, which results in the production of primordial black holes (PBHs), early formation of structure, reionization of the Universe, and a rich array of astrophysical events. The Ω-problem is also addressed by our scenario. Allowing the density perturbations produced by the second episode of inflation to be large also lessens the fine-tuning required in the scalar potential and makes reheating much easier. We briefly speculate on the possibility that the second episode of inflation proceeds through the nucleation of bubbles, which today manifest themselves as empty bubbles whose surfaces are covered with galaxies. 37 refs., 1 fig

  8. A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.

    Science.gov (United States)

    Amalraj, Augustine; Varma, Karthik; Jacob, Joby; Divya, Chandradhara; Kunnumakkara, Ajaikumar B; Stohs, Sidney J; Gopi, Sreeraj

    2017-10-01

    Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder. The long-term use of currently available drugs for the treatment of RA has many potential side effects. Natural phytonutrients may serve as alternative strategies for the safe and effective treatment of RA, and curcuminoids have been used in Ayurvedic medicine for the treatment of inflammatory conditions for centuries. In this study, a novel, highly bioavailable form of curcumin in a completely natural turmeric matrix was evaluated for its ability to improve the clinical symptoms of RA. A randomized, double-blind, placebo-controlled, three-arm, parallel-group study was conducted to evaluate the comparative efficacy of two different doses of curcumin with that of a placebo in active RA patients. Twelve patients in each group received placebo, 250 or 500 mg of the curcumin product twice daily for 90 days. The responses of the patients were assessed using the American College of Rheumatology (ACR) response, visual analog scale (VAS), C-reactive protein (CRP), Disease Activity Score 28 (DAS28), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) values. RA patients who received the curcumin product at both low and high doses reported statistically significant changes in their clinical symptoms at the end of the study. These observations were confirmed by significant changes in ESR, CPR, and RF values in patients receiving the study product compared to baseline and placebo. The results indicate that this novel curcumin in a turmeric matrix acts as an analgesic and anti-inflammatory agent for the management of RA at a dose as low as 250 mg twice daily as evidenced by significant improvement in the ESR, CRP, VAS, RF, DAS28, and ACR responses compared to placebo. Both doses of the study product were well tolerated and without side effects.

  9. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms

    Directory of Open Access Journals (Sweden)

    Feldman Samantha

    2009-11-01

    Full Text Available Abstract Background This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence but no gastrointestinal (GI diagnoses to explain the symptoms. Methods Sixty-one adults were enrolled (age 36.5 ± 12.6 years; height 165.1 ± 9.2 cm; weight 75.4 ± 17.3 kg and randomized to either Digestive Advantage™ Gas Defense Formula - (GanedenBC30 Bacillus coagulans GBI-30, 6086: n = 30; or Placebo: n = 31. Study subjects were evaluated every two weeks over a four-week period using validated questionnaires and standard biochemical safety testing. Outcome criteria of interest included change from baseline in Gastrointestinal Symptom Rating Scale (GSRS abdominal pain, abdominal distention, flatus, and the Severity of Dyspepsia Assessment (SODA bloating and gas subscores over four weeks of product use. Results Measured against the placebo, subjects in the probiotic group achieved significant improvements in GSRS abdominal pain subscore (p = 0.046 and the GSRS total score (p = 0.048, with a strong trend for improvement on the GSRS abdominal distension subscore (p = 0.061. A strong placebo effect was evident which could explain the lack of statistical significant differences between the groups for many of the efficacy variables. Conclusion In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses. Trial Registration ClinicalTrials.gov Identifier: NCT00881322

  10. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms

    Science.gov (United States)

    2009-01-01

    Background This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence) but no gastrointestinal (GI) diagnoses to explain the symptoms. Methods Sixty-one adults were enrolled (age 36.5 ± 12.6 years; height 165.1 ± 9.2 cm; weight 75.4 ± 17.3 kg) and randomized to either Digestive Advantage™ Gas Defense Formula - (GanedenBC30 Bacillus coagulans GBI-30, 6086): n = 30; or Placebo: n = 31. Study subjects were evaluated every two weeks over a four-week period using validated questionnaires and standard biochemical safety testing. Outcome criteria of interest included change from baseline in Gastrointestinal Symptom Rating Scale (GSRS) abdominal pain, abdominal distention, flatus, and the Severity of Dyspepsia Assessment (SODA) bloating and gas subscores over four weeks of product use. Results Measured against the placebo, subjects in the probiotic group achieved significant improvements in GSRS abdominal pain subscore (p = 0.046) and the GSRS total score (p = 0.048), with a strong trend for improvement on the GSRS abdominal distension subscore (p = 0.061). A strong placebo effect was evident which could explain the lack of statistical significant differences between the groups for many of the efficacy variables. Conclusion In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses. Trial Registration ClinicalTrials.gov Identifier: NCT00881322 PMID:19922649

  11. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms.

    Science.gov (United States)

    Kalman, Douglas S; Schwartz, Howard I; Alvarez, Patricia; Feldman, Samantha; Pezzullo, John C; Krieger, Diane R

    2009-11-18

    This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence) but no gastrointestinal (GI) diagnoses to explain the symptoms. Sixty-one adults were enrolled (age 36.5 +/- 12.6 years; height 165.1 +/- 9.2 cm; weight 75.4 +/- 17.3 kg) and randomized to either Digestive Advantage Gas Defense Formula - (GanedenBC30 Bacillus coagulans GBI-30, 6086): n = 30; or Placebo: n = 31. Study subjects were evaluated every two weeks over a four-week period using validated questionnaires and standard biochemical safety testing. Outcome criteria of interest included change from baseline in Gastrointestinal Symptom Rating Scale (GSRS) abdominal pain, abdominal distention, flatus, and the Severity of Dyspepsia Assessment (SODA) bloating and gas subscores over four weeks of product use. Measured against the placebo, subjects in the probiotic group achieved significant improvements in GSRS abdominal pain subscore (p = 0.046) and the GSRS total score (p = 0.048), with a strong trend for improvement on the GSRS abdominal distension subscore (p = 0.061). A strong placebo effect was evident which could explain the lack of statistical significant differences between the groups for many of the efficacy variables. In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses. ClinicalTrials.gov Identifier: NCT00881322.

  12. A phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of etelcalcetide (ONO-5163/AMG 416), a novel intravenous calcimimetic, for secondary hyperparathyroidism in Japanese haemodialysis patients.

    Science.gov (United States)

    Fukagawa, Masafumi; Yokoyama, Keitaro; Shigematsu, Takashi; Akiba, Takashi; Fujii, Akifumi; Kuramoto, Takuto; Odani, Motoi; Akizawa, Tadao

    2017-10-01

    Secondary hyperparathyroidism (SHPT) is a major complication associated with chronic kidney disease. We evaluated the efficacy and safety of etelcalcetide (ONO-5163/AMG 416), a novel intravenous calcimimetic, in Japanese haemodialysis patients with SHPT. In this phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study, etelcalcetide was administered three times per week at an initial dose of 5 mg, and subsequently adjusted to doses between 2.5 and 15 mg at 4-week intervals for 12 weeks. A total of 155 SHPT patients with serum intact parathyroid hormone (iPTH) levels ≥300 pg/mL were assigned to receive etelcalcetide (n = 78) or placebo (n = 77). The primary endpoint was the proportion of patients with decreased serum iPTH to the target range proposed by the Japanese Society for Dialysis Therapy (60-240 pg/mL). The major secondary endpoint was the proportion of patients with ≥30% reductions in serum iPTH from baseline. The proportion of patients meeting the primary endpoint was significantly higher for etelcalcetide (59.0%) versus placebo (1.3%). Similarly, the proportion of patients meeting the major secondary endpoint was significantly higher for etelcalcetide (76.9%) versus placebo (5.2%). Serum albumin-corrected calcium, phosphorus and intact fibroblast growth factor-23 levels were decreased in the etelcalcetide group. Nausea, vomiting and symptomatic hypocalcaemia were mild with etelcalcetide. Serious adverse events related to etelcalcetide were not observed. This study demonstrated the efficacy and safety of etelcalcetide. As the only available intravenous calcium-sensing receptor agonist, etelcalcetide is likely to provide a new treatment option for SHPT in haemodialysis patients. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA.

  13. Double Outlet Right Ventricle

    Science.gov (United States)

    ... Right Ventricle Menu Topics Topics FAQs Double Outlet Right Ventricle Double outlet right ventricle (DORV) is a rare form of congenital heart disease. En español Double outlet right ventricle (DORV) is a rare form of congenital ...

  14. Phase 1, randomized, parallel-group, double-blind, placebo-controlled trial to evaluate the effects of erenumab (AMG 334) and concomitant sumatriptan on blood pressure in healthy volunteers.

    Science.gov (United States)

    de Hoon, Jan; Van Hecken, Anne; Vandermeulen, Corinne; Herbots, Marissa; Kubo, Yumi; Lee, Ed; Eisele, Osa; Vargas, Gabriel; Gabriel, Kristin

    2018-01-01

    Objectives The aim of this study was to assess the effects of concomitant administration of erenumab and sumatriptan on resting blood pressure, pharmacokinetics, safety, and tolerability in healthy subjects. Methods In this phase 1, parallel-group, one-way crossover, double-blind, placebo-controlled study, healthy adult subjects were randomized (1:2) to receive either intravenous placebo and subcutaneous sumatriptan 12 mg (i.e. two 6-mg injections separated by 1 hour) or intravenous erenumab 140 mg and subcutaneous sumatriptan 12 mg. Blood pressure was measured pre-dose and at prespecified times post-dose. The primary endpoint was individual time-weighted averages of mean arterial pressure, measured from 0 hours to 2.5 hours after the first dose of sumatriptan. Pharmacokinetic parameters for sumatriptan were evaluated by calculating geometric mean ratios (erenumab and sumatriptan/placebo and sumatriptan). Adverse events and anti-erenumab antibodies were also evaluated. Results A total of 34 subjects were randomized and included in the analysis. Least squares mean (standard error) time-weighted averages of mean arterial pressure were 87.4 (1.0) mmHg for the placebo and sumatriptan group and 87.4 (1.2) mmHg for the erenumab and sumatriptan group. Mean difference in mean arterial pressure between groups was -0.04 mmHg (90% confidence interval: -2.2, 2.1). Geometric mean ratio estimates for maximum plasma concentration of sumatriptan was 0.95 (90% confidence interval: 0.82, 1.09), area under the plasma concentration-time curve (AUC) from time 0 to 6 hours was 0.98 (90% confidence interval: 0.93, 1.03), and AUC from time 0 to infinity was 1.00 (90% confidence interval: 0.96, 1.05). No clinically relevant safety findings for co-administration of sumatriptan and erenumab were identified. Conclusion Co-administration of erenumab and sumatriptan had no additional effect on resting blood pressure or on pharmacokinetics of sumatriptan. ClinicalTrials.gov, NCT

  15. Double hard scattering without double counting

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Gaunt, Jonathan R. [VU Univ. Amsterdam (Netherlands). NIKHEF Theory Group; Schoenwald, Kay [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2017-02-15

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  16. Double hard scattering without double counting

    International Nuclear Information System (INIS)

    Diehl, Markus; Gaunt, Jonathan R.

    2017-02-01

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  17. A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study.

    Science.gov (United States)

    Park, Won; Hrycaj, Pawel; Jeka, Slawomir; Kovalenko, Volodymyr; Lysenko, Grygorii; Miranda, Pedro; Mikazane, Helena; Gutierrez-Ureña, Sergio; Lim, MieJin; Lee, Yeon-Ah; Lee, Sang Joon; Kim, HoUng; Yoo, Dae Hyun; Braun, Jürgen

    2013-10-01

    To compare the pharmacokinetics (PK), safety and efficacy of innovator infliximab (INX) and CT-P13, a biosimilar to INX, in patients with active ankylosing spondylitis (AS). Phase 1 randomised, double-blind, multicentre, multinational, parallel-group study. Patients were randomised to receive 5 mg/kg of CT-P13 (n=125) or INX (n=125). Primary endpoints were area under the concentration-time curve (AUC) at steady state and observed maximum steady state serum concentration (Cmax,ss) between weeks 22 and 30. Additional PK, efficacy endpoints, including 20% and 40% improvement response according to Assessment in Ankylosing Spondylitis International Working Group criteria (ASAS20 and ASAS40), and safety outcomes were also assessed. Geometric mean AUC was 32 765.8 μgh/ml for CT-P13 and 31 359.3 μgh/ml for INX. Geometric mean Cmax,ss was 147.0 μg/ml for CT-P13 and 144.8 μg/ml for INX. The ratio of geometric means was 104.5% (90% CI 94% to 116%) for AUC and 101.5% (90% CI 95% to 109%) for Cmax,ss. ASAS20 and ASAS40 responses at week 30 were 70.5% and 51.8% for CT-P13 and 72.4% and 47.4% for INX, respectively. In the CT-P13 and INX groups more than one adverse event occurred in 64.8% and 63.9% of patients, infusion reactions occurred in 3.9% and 4.9%, active tuberculosis occurred in 1.6% and 0.8%, and 27.4% and 22.5% of patients tested positive for anti-drug antibodies, respectively. The PK profiles of CT-P13 and INX were equivalent in patients with active AS. CT-P13 was well tolerated, with an efficacy and safety profile comparable to that of INX up to week 30.

  18. Growth hormone (GH) effects on bone and collagen turnover in healthy adults and its potential as a marker of GH abuse in sports: a double blind, placebo-controlled study. The GH-2000 Study Group.

    Science.gov (United States)

    Longobardi, S; Keay, N; Ehrnborg, C; Cittadini, A; Rosén, T; Dall, R; Boroujerdi, M A; Bassett, E E; Healy, M L; Pentecost, C; Wallace, J D; Powrie, J; Jørgensen, J O; Saccà, L

    2000-04-01

    The effects of GH on bone remodeling in healthy adults have not been systematically investigated. An analysis of these effects might provide insights into GH physiology and might yield data useful for the detection of GH doping in sports. The aim of this study was to evaluate the effects of GH administration on biochemical markers of bone and collagen turnover in healthy volunteers. Ninety-nine healthy volunteers of both sexes were enrolled in a multicenter, randomized, double blind, placebo-controlled study and assigned to receive either placebo (40 subjects) or recombinant human GH (0.1 IU/kg day in 29 subjects and 0.2 IU/kg x day in 30 subjects). The treatment duration was 28 days, followed by a 56-day wash-out period. The biochemical markers evaluated were the bone formation markers osteocalcin and C-terminal propeptide of type I procollagen, the resorption marker type I collagen telopeptide, and the soft tissue marker procollagen type III. All variables increased on days 21 and 28 in the two active treatment groups vs. levels in both the baseline (P < 0.01) and placebo (P < 0.01) groups. The increment was more pronounced in the 0.2 IU/kg-day group and remained significant on day 84 for procollagen type III (from 0.53 +/- 0.13 to 0.61 +/- 0.14 kU/L; P < 0.02) and osteocalcin (from 12.2 + 2.9 to 14.6 +/- 3.6 UG/L; P < 0.02), whereas levels of C-terminal propeptide of type I procollagen and type I collagen telopeptide declined after day 42 and were no longer significantly above baseline on day 84 (from 3.9 +/- 1.2 to 5.1 +/-1.5 microg/L and from 174 +/- 60 to 173 +/- 53 microg/L, respectively). Gender-related differences were observed in the study; females were less responsive than males to GH administration with respect to procollagen type III and type I collagen telopeptide (P < 0.001). In conclusion, exogenous GH administration affects the biochemical parameters of bone and collagen turnover in a dose- and gender-dependent manner. As GH-induced modifications

  19. Representation of SO(4,1) group and Hawking effect in the de-Sitter space

    International Nuclear Information System (INIS)

    Bogush, A.A.; Otchik, V.S.

    1983-01-01

    Expression relating the solution of the equation for particles with spin 1/2 to matrix elements of group SO(4, 1), is obtained. When using the relation of the Dirac equation solutions in the de Sitter space with matrix elements of representations of group SO(4, 1) the presence of the Hawking effect in the space is established. The de Sitter space is considered as 4-dimensional hyperboloid, inserted into 5-dimensional pseudo-Euclidean space. It is established, that the average number of emitted spinor particles obeys the Fermi-Dirac distribution

  20. Does Zinc Sulfate Prevent Therapy-Induced Taste Alterations in Head and Neck Cancer Patients? Results of Phase III Double-Blind, Placebo-Controlled Trial from the North Central Cancer Treatment Group (N01C4)

    International Nuclear Information System (INIS)

    Halyard, Michele Y.; Jatoi, Aminah; Sloan, Jeff A.; Bearden, James D.; Vora, Sujay A.; Atherton, Pamela J.; Perez, Edith A.; Soori, Gammi; Zalduendo, Anthony C.; Zhu, Angela; Stella, Philip J.; Loprinzi, Charles L.

    2007-01-01

    Purpose: Taste alterations (dysgeusia) are well described in head and neck cancer patients who undergo radiotherapy (RT). Anecdotal observations and pilot studies have suggested zinc may mitigate these symptoms. This multi-institutional, double-blind, placebo-controlled trial was conducted to provide definitive evidence of this mineral's palliative efficacy. Methods and Materials: A total of 169 evaluable patients were randomly assigned to zinc sulfate 45 mg orally three times daily vs. placebo. Treatment was to be given throughout RT and for 1 month after. All patients were scheduled to receive ≥2,000 cGy of external beam RT to ≥30% of the oral cavity, were able to take oral medication, and had no oral thrush at study entry. Changes in taste were assessed using the previously validated Wickham questionnaire. Results: At baseline, the groups were comparable in age, gender, and planned radiation dose (<6,000 vs. ≥6,000 cGy). Overall, 61 zinc-treated (73%) and 71 placebo-exposed (84%) patients described taste alterations during the first 2 months (p = 0.16). The median interval to taste alterations was 2.3 vs. 1.6 weeks in the zinc-treated and placebo-exposed patients, respectively (p = 0.09). The reported taste alterations included the absence of any taste (16%), bitter taste (8%), salty taste (5%), sour taste (4%), sweet taste (5%), and the presence of a metallic taste (10%), as well as other descriptions provided by a write in response (81%). Zinc sulfate did not favorably affect the interval to taste recovery. Conclusion: Zinc sulfate, as prescribed in this trial, did not prevent taste alterations in cancer patients who were undergoing RT to the oral pharynx

  1. Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol).

    Science.gov (United States)

    Ellegaard, Pernille Kempel; Licht, Rasmus Wentzer; Poulsen, Henrik Enghusen; Nielsen, René Ernst; Berk, Michael; Dean, Olivia May; Mohebbi, Mohammadreza; Nielsen, Connie Thuroee

    2018-04-05

    Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depressive episodes, especially compared with the efficacy of treatment for acute mania. N-Acetylcysteine (NAC) has been explored for psychiatric disorders for some time given its antioxidant and anti-inflammatory properties. The current trial aims at testing the clinical effects of adjunctive NAC treatment (compared to placebo) for bipolar depression. We will also explore the biological effects of NAC in this context. We hypothesize that adjunctive NAC treatment will reduce symptoms of depression, which will be reflected by changes in selected markers of oxidative stress. In the study, we will include adults diagnosed with bipolar disorder, in a currently depressive episode. Participants will undertake a 20-week, adjunctive, randomized, double-blinded, parallel group placebo-controlled trial comparing 3 grams of adjunctive NAC daily with placebo. The primary outcome is the mean change over time from baseline to end of study on the Montgomery-Asberg Depression Rating Scale (MADRS). Among the secondary outcomes are mean changes from baseline to end of study on the Bech-Rafaelsen Melancholia Scale (MES), the Young Mania Rating Scale (YMRS), the WHO-Five Well-being Index (WHO-5), the Global Assessment of Functioning scale (GAF-F), the Global Assessment of Symptoms scale (GAF-S) and the Clinical Global Impression-Severity scale (CGI-S). The potential effects on oxidative stress by NAC treatment will be measured through urine and blood samples. DNA will be examined for potential polymorphisms related to oxidative defences. Registered at The European Clinical Trials Database, ClinicalTrials.gov: NCT02294591 and The Danish Data Protection Agency: 2008-58-0035.

  2. A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects.

    Science.gov (United States)

    Berg, Jolene Kay; Kim, Eric H; Li, Benjamin; Joelsson, Bo; Youssef, Nader N

    2014-02-12

    Teduglutide, a recombinant analog of human glucagon-like peptide (GLP)-2, is a novel therapy recently approved for the treatment of adult patients with short bowel syndrome who are dependent on parenteral support. Previous studies assessing the effect of GLP-2 on gastric emptying in humans have yielded inconsistent results, with some studies showing no effect and others documenting a GLP-2-dependent delay in gastric emptying. The primary objective of this study was to assess the effect of teduglutide on gastric emptying of liquids in healthy subjects, as measured by the pharmacokinetics of acetaminophen. This double-blind, parallel-group, single-center study enrolled and randomized 36 healthy subjects (22 men, 14 women) to receive subcutaneous doses of teduglutide 4 mg or placebo (2:1 ratio; 23:13) once daily on Days 1 through 10 in the morning. Gastric emptying of a mixed nutrient liquid meal was assessed by measuring acetaminophen levels predose and at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 3.5, 4, 5, 6, 8, 10, 12, and 14 hours after administration of 1000 mg acetaminophen on Days 0 and 10. The primary study endpoint was a pharmacokinetic analysis of acetaminophen absorption in subjects receiving teduglutide or placebo. No significant differences in gastric emptying of liquids (acetaminophen area under the concentration [AUC] vs time curve from time 0 to the last measurable concentration, AUC extrapolated to infinity, maximum concentration [Cmax], and time to Cmax) were observed on Day 10 in subjects receiving teduglutide 4 mg versus subjects receiving placebo. There were no serious adverse events (AEs), deaths, or discontinuations due to an AE reported during the study. Teduglutide 4 mg/day for 10 days does not affect gastric emptying of liquids in healthy subjects as measured by acetaminophen pharmacokinetics. No unexpected safety signals were observed. This study was registered at ClinicalTrials.gov, identifier NCT01209351.

  3. The Expenditures for Academic Inpatient Care of Inflammatory Bowel Disease Patients Are Almost Double Compared with Average Academic Gastroenterology and Hepatology Cases and Not Fully Recovered by Diagnosis-Related Group (DRG) Proceeds.

    Science.gov (United States)

    Baumgart, Daniel C; le Claire, Marie

    2016-01-01

    Crohn's disease (CD) and ulcerative colitis (UC) challenge economies worldwide. Detailed health economic data of DRG based academic inpatient care for inflammatory bowel disease (IBD) patients in Europe is unavailable. IBD was identified through ICD-10 K50 and K51 code groups. We took an actual costing approach, compared expenditures to G-DRG and non-DRG proceeds and performed detailed cost center and type accounting to identify coverage determinants. Of all 3093 hospitalized cases at our department, 164 were CD and 157 UC inpatients in 2012. On average, they were 44.1 (CD 44.9 UC 43.3 all 58) years old, stayed 10.1 (CD 11.8 UC 8.4 vs. all 8) days, carried 5.8 (CD 6.4 UC 5.2 vs. all 6.8) secondary diagnoses, received 7.4 (CD 7.7 UC 7 vs. all 6.2) procedures, had a higher cost weight (CD 2.8 UC 2.4 vs. all 1.6) and required more intense nursing. Their care was more costly (means: total cost IBD 8477€ CD 9051€ UC 7903€ vs. all 5078€). However, expenditures were not fully recovered by DRG proceeds (means: IBD 7413€, CD 8441€, UC 6384€ vs all 4758€). We discovered substantial disease specific mismatches in cost centers and types and identified the medical ward personnel and materials budgets to be most imbalanced. Non-DRG proceeds were almost double (IBD 16.1% vs. all 8.2%), but did not balance deficits at total coverage analysis, that found medications (antimicrobials, biologics and blood products), medical materials (mostly endoscopy items) to contribute most to the deficit. DRGs challenge sophisticated IBD care.

  4. The impact of concurrent granulocyte macrophage-colony stimulating factor on radiation-induced mucositis in head and neck cancer patients: A double-blind placebo-controlled prospective Phase III study by Radiation Therapy Oncology Group 9901

    International Nuclear Information System (INIS)

    Ryu, Janice K.; Swann, Suzanne; LeVeque, Francis; Scarantino, Charles W.; Johnson, Darlene J.; Chen, Allan; Fortin, Andre; Pollock, JonDavid; Kim, Harold; Ang, Kian K.

    2007-01-01

    Purpose: Based on early clinical evidence of potential mucosal protection by granulocyte-macrophage colony stimulating factor (GM-CSF), the Radiation Therapy Oncology Group conducted a double-blind, placebo-controlled, randomized study to test the efficacy and safety of GM-CSF in reducing the severity and duration of mucosal injury and pain (mucositis) associated with curative radiotherapy (RT) in head-and-neck cancer patients. Methods and Materials: Eligible patients included those with head-and-neck cancer with radiation ports encompassing >50% of oral cavity and/or oropharynx. Standard RT ports were used to cover the primary tumor and regional lymphatics at risk in standard fractionation to 60-70 Gy. Concurrent cisplatin chemotherapy was allowed. Patients were randomized to receive subcutaneous injection of GM-CSF 250 μg/m 2 or placebo 3 times a week. Mucosal reaction was assessed during the course of RT using the National Cancer Institute Common Toxicity Criteria and the protocol-specific scoring system. Results: Between October 2000 and September 2002, 130 patients from 36 institutions were accrued. Nine patients (7%) were excluded from the analysis, 3 as a result of drug unavailability. More than 80% of the patients participated in the quality-of-life endpoint of this study. The GM-CSF did not cause any increase in toxicity compared with placebo. There was no statistically significant difference in the average mean mucositis score in the GM-CSF and placebo arms by a t test (p = 0.4006). Conclusion: This placebo-controlled, randomized study demonstrated no significant effect of GM-CSF given concurrently compared with placebo in reducing the severity or duration of RT-induced mucositis in patients undergoing definitive RT for head-and-neck cancer

  5. Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

    Science.gov (United States)

    Ludolph, Albert C; Schuster, Joachim; Dorst, Johannes; Dupuis, Luc; Dreyhaupt, Jens; Weishaupt, Jochen H; Kassubek, Jan; Weiland, Ulrike; Petri, Susanne; Meyer, Thomas; Grosskreutz, Julian; Schrank, Berthold; Boentert, Matthias; Emmer, Alexander; Hermann, Andreas; Zeller, Daniel; Prudlo, Johannes; Winkler, Andrea S; Grehl, Torsten; Heneka, Michael T; Wollebæk Johannesen, Siw; Göricke, Bettina

    2018-06-18

    Rasagiline, a monoamine oxidase B inhibitor with neuroprotective potential in Parkinson's disease, has shown a disease-modifying effect in the SOD1-Gly93Ala low-expressing mouse model of amyotrophic lateral sclerosis, both alone and in combination with riluzole. We sought to test whether or not rasagiline 1 mg/day can prolong survival in patients with amyotrophic lateral sclerosis also receiving riluzole. Patients with possible, probable, or definite amyotrophic lateral sclerosis were enrolled to our randomised, placebo-controlled, parallel-group, double-blind, phase 2 trial from 15 German network for motor neuron diseases (MND-NET) centres (university hospitals or clinics). Eligible patients were aged at least 18 years, had onset of progressive weakness within the 36 months before the study, had disease duration of more than 6 months and less than 3 years, and had a best-sitting slow vital capacity of at least 50%. After a 4-week screening period, eligible patients were randomly assigned (1:1) to receive either rasagiline (1 mg/day) or placebo in addition to riluzole (100 mg/day), after stratification for site of onset (bulbar or spinal) and study centre. Patients and all personnel assessing outcome parameters were masked to treatment allocation. Patients were followed up 2, 6, 12, and 18 months after randomisation. The primary endpoint was survival time, defined as the time to death or time to study cutoff date (ie, the last patient's last visit plus 14 days). Analyses of primary outcome and safety measures were done in all patients who received at least one dose of trial treatment (intention-to-treat population). The trial is registered with ClinicalTrials.gov, number NCT01879241. Between July 2, 2013, and Nov 11, 2014, 273 patients were screened for eligibility, and 252 patients were randomly assigned to receive rasagiline (n=127) or placebo (n=125). 126 patients taking rasagiline and 125 taking placebo were included in the intention-to-treat analysis. For the

  6. A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain.

    Science.gov (United States)

    Lee, Jae Hyup; Lee, Chong-Suh

    2013-11-01

    Chronic low back pain is a common condition that is often difficult to treat. The combination of tramadol hydrochloride and acetaminophen in an extended-release formulation has been shown to provide rapid and long-lasting analgesic effects resulting from the synergistic activity of these 2 active ingredients. The goal of this study was to evaluate the efficacy and safety of extended-release tramadol hydrochloride 75-mg/acetaminophen 650-mg fixed-dose combination tablets (TA-ER) for the treatment of chronic low back pain. This Phase III, double-blind, placebo-controlled, parallel-group study enrolled 245 patients with moderate to severe (≥4 cm on a 10-cm visual analog scale) chronic (≥3 months') low back pain insufficiently controlled by previous NSAIDs or cyclooxygenase-2-selective inhibitors and randomly assigned them to receive 4 weeks of either TA-ER or placebo. The primary efficacy end point was the percentage of patients with a pain intensity change rate ≥30% from baseline to final evaluation. Secondary end points included quality of life (Korean Short Form-36), functionality (Korean Oswestry Disability Index), and adverse events. The percentage of patients with a pain intensity change rate ≥30% was significantly higher (P Pain relief success rate from baseline was significantly higher with TA-ER versus placebo at days 8 and 15 but not at the final visit. Patients in the TA-ER group had significant improvements versus placebo in role-physical, general health, and reported health transition domains of the Korean Short Form-36 and significantly higher functional improvements in the personal care section of the Korean Oswestry Disability Index. Patient assessment of overall pain control as "very good" was also significantly higher with TA-ER than with placebo. Adverse events were reported more frequently with TA-ER than with placebo; the most common adverse events reported were nausea, dizziness, constipation, and vomiting. TA-ER was significantly more

  7. The Double-Deficit Hypothesis in Spanish Developmental Dyslexia

    Science.gov (United States)

    Jimenez, Juan E.; Hernandez-Valle, Isabel; Rodriguez, Cristina; Guzman, Remedios; Diaz, Alicia; Ortiz, Rosario

    2008-01-01

    The double-deficit hypothesis (DDH) of developmental dyslexia was investigated in seven to twelve year old Spanish children. It was observed that the double deficit (DD) group had the greatest difficulty with reading.

  8. A two-site, two-arm, 34-week, double-blind, parallel-group, randomized controlled trial of reduced nicotine cigarettes in smokers with mood and/or anxiety disorders: trial design and protocol

    Directory of Open Access Journals (Sweden)

    Sophia I. Allen

    2017-01-01

    Full Text Available Abstract Background The U.S. Food and Drug Administration can set standards for cigarettes that could include reducing their nicotine content. Such a standard should improve public health without causing unintended serious consequences for sub-populations. This study evaluates the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxicant exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders using a two-site, two-arm, double-blind, parallel group, randomized controlled trial (RCT in four phases over 34 weeks. Methods Adult smokers (N = 200 of 5 or more cigarettes per day will be randomized across two sites (Penn State and Massachusetts General. Participants must have not had a quit attempt in the prior month, nor be planning to quit in the next 6 months, meet criteria for a current or lifetime unipolar mood and/or anxiety disorder based on the structured Mini-International Neuropsychiatric Interview, and must not have an unstable medical or psychiatric condition. After a week of smoking their own cigarettes, participants receive two weeks of Spectrum research cigarettes with usual nicotine content (11.6 mg. After this baseline period, participants will be randomly assigned to continue smoking Spectrum research cigarettes that contain either (a Usual Nicotine Content (11.6 mg; or (b Reduced Nicotine Content: the nicotine content per cigarette is progressively reduced from approximately 11.6 mg to 0.2 mg in five steps over 18 weeks. At the end of the randomization phase, participants will be offered the choice to either (a quit smoking with assistance, (b continue smoking free research cigarettes, or (c return to purchasing their own cigarettes, for the final 12 weeks of the study. The primary outcome measure is blood cotinine; key secondary outcomes are: exhaled carbon monoxide, urinary total NNAL- 4-(methylnitrosamino-1-(3-pyridyl-1-butanol and 1-hydroxypyrene, oxidative

  9. Double quick, double click reversible peptide "stapling".

    Science.gov (United States)

    Grison, Claire M; Burslem, George M; Miles, Jennifer A; Pilsl, Ludwig K A; Yeo, David J; Imani, Zeynab; Warriner, Stuart L; Webb, Michael E; Wilson, Andrew J

    2017-07-01

    The development of constrained peptides for inhibition of protein-protein interactions is an emerging strategy in chemical biology and drug discovery. This manuscript introduces a versatile, rapid and reversible approach to constrain peptides in a bioactive helical conformation using BID and RNase S peptides as models. Dibromomaleimide is used to constrain BID and RNase S peptide sequence variants bearing cysteine (Cys) or homocysteine ( h Cys) amino acids spaced at i and i + 4 positions by double substitution. The constraint can be readily removed by displacement of the maleimide using excess thiol. This new constraining methodology results in enhanced α-helical conformation (BID and RNase S peptide) as demonstrated by circular dichroism and molecular dynamics simulations, resistance to proteolysis (BID) as demonstrated by trypsin proteolysis experiments and retained or enhanced potency of inhibition for Bcl-2 family protein-protein interactions (BID), or greater capability to restore the hydrolytic activity of the RNAse S protein (RNase S peptide). Finally, use of a dibromomaleimide functionalized with an alkyne permits further divergent functionalization through alkyne-azide cycloaddition chemistry on the constrained peptide with fluorescein, oligoethylene glycol or biotin groups to facilitate biophysical and cellular analyses. Hence this methodology may extend the scope and accessibility of peptide stapling.

  10. Double photoionisation spectra of molecules

    CERN Document Server

    Eland, John

    2017-01-01

    This book contains spectra of the doubly charged positive ions (dications) of some 75 molecules, including the major constituents of terrestrial and planetary atmospheres and prototypes of major chemical groups. It is intended to be a new resource for research in all areas of molecular spectroscopy involving high energy environments, both terrestrial and extra-terrestrial. All the spectra have been produced by photoionisation using laboratory lamps or synchrotron radiation and have been measured using the magnetic bottle time-of-flight technique by coincidence detection of correlated electron pairs. Full references to published work on the same species are given, though for several molecules these are the first published spectra. Double ionisation energies are listed and discussed in relation to the molecular electronic structure of the molecules. A full introduction to the field of molecular double ionisation is included and the mechanisms by which double photoionisation can occur are examined in detail. A p...

  11. International double taxation

    OpenAIRE

    Körbl, Hugo

    2012-01-01

    1 Summary This thesis deals with the issue of international double taxation of income and capital and methods for its solution. International double taxation is an issue which states began to deal with in the late 19th century. This interest intensified after the First World War when also the League of Nations (predecessor of the United Nations) began to deal with international double taxation. Most attention the phenomenon of double taxation of income and capital with an international elemen...

  12. Double layers in space

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-07-01

    For more than a decade it has been realised that electrostatic double layers are likely to occur in space. We briefly discuss the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Author)

  13. Double layers in space

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-01-01

    For more than a decade it has been realised that electrostatic double layers are likely to occur in space. The author briefly discusses the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Auth.)

  14. Double-double effect and coordination number

    International Nuclear Information System (INIS)

    Mioduski, T.

    1992-01-01

    The original method of interpretation together with its theoretical foundations is developed, making it possible to use location and direction of the double-double (tetrad) effect within the Ln and An series to determine the coordination number (CN) complexes of the f-block elements. The method is applied for potentiometric and radiometric equilibrium studies. It has been pointed and that the decisive factor for the direction of the double-double effect in the case of the Gibbs energy variations is a difference in the CN of the f-element ion between the reaction product complex and that for the reaction substrate the ''regular'' effect for a given tetrad is accompanied by decrease in the CN while the ''reverse'' effect by increase in the CN. (author). 122 refs, 5 tabs, 8 figs

  15. Early-transition-metal ketenimine complexes. Synthesis, reactivity, and structural characterization of complexes with. eta. sup 2 (C,N)-ketenimine groups bound to the halogenobis((trimethylsilyl)cyclopentadienyl)niobium unit. X-ray structure of Nb(. eta. sup 5 -C sub 5 H sub 4 SiMe sub 3 ) sub 2 Cl(. eta. sup 2 (C,N)-PhN double bond C double bond CPh sub 2 )

    Energy Technology Data Exchange (ETDEWEB)

    Antinolo, A.; Fajardo, M.; Lopez Mardomingo, C.; Otero, A. (Univ. de Alcala de Henares (Spain)); Mourad, Y.; Mugnier, Y. (Centre National de la Recherche Scientifique, Dijon (France)); Sanz-Aparicio, J.; Fonseca, I.; Florencio, F. (CSIC, Madrid (Spain))

    1990-11-01

    The reaction of Nb({eta}{sup 5}-C{sub 5}H{sub 4}SiMe{sub 3}){sub 2}X (X = Cl, Br) with 1 equiv of various ketenimines, R{sup 1}N{double bond}C{double bond}CR{sup 2}R{sup 3}, leads to the niobium derivatives Nb({eta}{sup 5}-C{sub 5}H{sub 4}SiMe{sub 3}){sub 2}X({eta}{sup 2}(C,N)-R{sup 1}N{double bond}C{double bond}CR{sup 2}R{sup 3}) (1, X = Cl, R{sup 1} = R{sup 2} = R{sup 3} = C{sub 6}H{sub 5}; 2, X = Cl, R{sup 1} = p-CH{sub 3}-C{sub 6}H{sub 4}, R{sup 2} = R{sup 3} = C{sub 6}H{sub 5}; 3, X = Br, R{sup 1} = R{sup 2} = R{sup 3} = C{sub 6}H{sub 5}; 4, X = Br, R{sup 1} = p-CH{sub 3}-C{sub 6}H{sub 4}, R{sup 2} = R{sup 3} = C{sub 6}H{sub 5}; 5, X = Cl, R{sup 1} = R{sup 2} = C{sub 6}H{sub 5}, R{sup 3} = CH{sub 3}; 6, X = Br, R{sup 1} = R{sup 2} = C{sub 6}H{sub 5}, R{sup 3} = CH{sub 3}) with the expected ketenimine C{double bond}N bonding mode. Reduction of 1 with 1 equiv of Na/Hg gives the complex Nb({eta}{sup 5}-C{sub 5}H{sub 4}SiMe{sub 3}){sub 2}({eta}{sup 2}(C,N)-PhN{double bond}C{double bond}CPh{sub 2}) (9) as a paramagnetic compound. The reduction of 9 with 1 equiv of Na/Hg and the subsequent addition of a proton source (ethanol) leads to the iminoacyl compound Nb({eta}{sup 5}-C{sub 5}H{sub 4}SiMe{sub 3}){sub 2}(CRNR{sup 1}) (10, R = CH(Ph{sub 2}), R{sup 1} = Ph). The one- and two-electron reductions of 1 have been studied by cyclic voltammetry experiments. The structure of 1 was determined by single-crystal X-ray diffractometry: a = 24.4904 (14) {angstrom}, b = 11.0435 (04) {angstrom}, c = 26.6130 (15) {angstrom}, {beta} = 109.890 (5){degree}, monoclinic, space group C2/c, Z = 8, V = 6,768.4 (5) {angstrom}{sup 3}, {rho}{sub calcd} = 1.3194 g/mL, R = 0.048, R{sub w} = 0.060 based on 4,806 observed reflections. The structure contains a niobium atom bonded to two cyclopentadienyl rings in a {eta}{sup 5} fashion; the coordination of the metal is completed by a Cl atom and a {eta}{sup 2}(C,N)-bonded ketenimine ligand.

  16. Introduction to quantum groups

    International Nuclear Information System (INIS)

    Sudbery, A.

    1996-01-01

    These pedagogical lectures contain some motivation for the study of quantum groups; a definition of ''quasi triangular Hopf algebra'' with explanations of all the concepts required to build it up; descriptions of quantised universal enveloping algebras and the quantum double; and an account of quantised function algebras and the action of quantum groups on quantum spaces. (author)

  17. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms

    OpenAIRE

    Feldman Samantha; Alvarez Patricia; Schwartz Howard I; Kalman Douglas S; Pezzullo John C; Krieger Diane R

    2009-01-01

    Abstract Background This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence) but no gastrointestinal (GI) diagnoses to explain the symptoms. Methods Sixty-one adults were enrolled (age 36.5 ± 12.6 years; height 165.1 ± 9.2 cm; weight 75.4 ± 17.3 kg) and randomized to either Digest...

  18. Double-trace deformations of conformal correlations

    Science.gov (United States)

    Giombi, Simone; Kirilin, Vladimir; Perlmutter, Eric

    2018-02-01

    Large N conformal field theories often admit unitary renormalization group flows triggered by double-trace deformations. We compute the change in scalar four-point functions under double-trace flow, to leading order in 1/ N. This has a simple dual in AdS, where the flow is implemented by a change of boundary conditions, and provides a physical interpretation of single-valued conformal partial waves. We extract the change in the conformal dimensions and three-point coefficients of infinite families of double-trace composite operators. Some of these quantities are found to be sign-definite under double-trace flow. As an application, we derive anomalous dimensions of spinning double-trace operators comprised of non-singlet constituents in the O( N) vector model.

  19. Observing Double Stars

    Science.gov (United States)

    Genet, Russell M.; Fulton, B. J.; Bianco, Federica B.; Martinez, John; Baxter, John; Brewer, Mark; Carro, Joseph; Collins, Sarah; Estrada, Chris; Johnson, Jolyon; Salam, Akash; Wallen, Vera; Warren, Naomi; Smith, Thomas C.; Armstrong, James D.; McGaughey, Steve; Pye, John; Mohanan, Kakkala; Church, Rebecca

    2012-05-01

    Double stars have been systematically observed since William Herschel initiated his program in 1779. In 1803 he reported that, to his surprise, many of the systems he had been observing for a quarter century were gravitationally bound binary stars. In 1830 the first binary orbital solution was obtained, leading eventually to the determination of stellar masses. Double star observations have been a prolific field, with observations and discoveries - often made by students and amateurs - routinely published in a number of specialized journals such as the Journal of Double Star Observations. All published double star observations from Herschel's to the present have been incorporated in the Washington Double Star Catalog. In addition to reviewing the history of visual double stars, we discuss four observational technologies and illustrate these with our own observational results from both California and Hawaii on telescopes ranging from small SCTs to the 2-meter Faulkes Telescope North on Haleakala. Two of these technologies are visual observations aimed primarily at published "hands-on" student science education, and CCD observations of both bright and very faint doubles. The other two are recent technologies that have launched a double star renaissance. These are lucky imaging and speckle interferometry, both of which can use electron-multiplying CCD cameras to allow short (30 ms or less) exposures that are read out at high speed with very low noise. Analysis of thousands of high speed exposures allows normal seeing limitations to be overcome so very close doubles can be accurately measured.

  20. Formation of double layers

    International Nuclear Information System (INIS)

    Leung, P.; Wong, A.Y.; Quon, B.H.

    1981-01-01

    Experiments on both stationary and propagating double layers and a related analytical model are described. Stationary double layers were produced in a multiple plasma device, in which an electron drift current was present. An investigation of the plasma parameters for the stable double layer condition is described. The particle distribution in the stable double layer establishes a potential profile, which creates electron and ion beams that excite plasma instabilities. The measured characteristics of the instabilities are consistent with the existence of the double layer. Propagating double layers are formed when the initial electron drift current is large. Ths slopes of the transition region increase as they propagate. A physical model for the formation of a double layer in the experimental device is described. This model explains the formation of the low potential region on the basis of the space charge. This space charge is created by the electron drift current. The model also accounts for the role of ions in double layer formation and explains the formation of moving double layers. (Auth.)

  1. The topology of Double Field Theory

    Science.gov (United States)

    Hassler, Falk

    2018-04-01

    We describe the doubled space of Double Field Theory as a group manifold G with an arbitrary generalized metric. Local information from the latter is not relevant to our discussion and so G only captures the topology of the doubled space. Strong Constraint solutions are maximal isotropic submanifold M in G. We construct them and their Generalized Geometry in Double Field Theory on Group Manifolds. In general, G admits different physical subspace M which are Poisson-Lie T-dual to each other. By studying two examples, we reproduce the topology changes induced by T-duality with non-trivial H-flux which were discussed by Bouwknegt, Evslin and Mathai [1].

  2. Double deflation and aggregation

    NARCIS (Netherlands)

    Dietzenbacher, Erik; Hoen, A.R.

    Published input-output tables in constant prices are relatively scarce. Therefore, input-output tables often have to be deflated by the practitioners themselves. The method of double deflation is used predominantly for this purpose. The present paper shows that the double-deflation method is subject

  3. General relation between the group delay and dwell time in multicomponent electron systems

    Science.gov (United States)

    Zhai, Feng; Lu, Junqiang

    2016-10-01

    For multicomponent electron scattering states, we derive a general relation between the Wigner group delay and the Bohmian dwell time. It is found that the definition of group delay should account for the phase of the spinor wave functions of propagating modes. The difference between the group delay and dwell time comes from both the interference delay and the decaying modes. For barrier tunneling of helical electrons on a surface of topological insulators, our calculations including the trigonal-warping term show that the decaying modes can contribute greatly to the group delay. The derived relation between the group delay and the dwell time is helpful to unify the two definitions of tunneling time in a quite general situation.

  4. Particular boundary condition ensures that a fermion in d=1+5, compactified on a finite disk, manifests d=1+3 as a massless spinor with a charge 1/2, mass protected and chirally coupled to the gauge field

    DEFF Research Database (Denmark)

    Borstnik, N. M.; Nielsen, Holger Frits Bech

    2008-01-01

    The genuine Kaluza-Klein-like theories-with no fields in addition to gravity-have difficulties with the existence of massless spinors after the compactification of some space dimensions [E. Witten, Nucl. Phys. B 186 (1981) 412; E. Witten, Fermion quantum numbers in Kaluza-Klein theories, Princeto...

  5. Black Women: Double Solos in the Workplace.

    Science.gov (United States)

    Fontaine, Deborah C.; Greenlee, Shelia P.

    1993-01-01

    Studies 12 black women in solo status positions in academia. Solo status is being the only member, or one of a small number, of a sex or racial group or both, in the workplace. As double solos, these women felt they had to outperform majority group counterparts. Common perceptions of barriers and facilitators are discussed. (SLD)

  6. LDL-cholesterol lowering activity of a blend of rice bran oil and safflower oil (8:2) in patients with hyperlipidaemia: a proof of concept, double blind, controlled, randomised parallel group study.

    Science.gov (United States)

    Malve, Harshad; Kerkar, Prafulla; Mishra, Nidheesh; Loke, Sanjita; Rege, N N; Marwaha-Jaspal, Ankita; Jainani, Kiran J

    2010-11-01

    Cardiovascular diseases have emerged as major health burden worldwide in recent times. Low density lipoprotein cholesterol (LDL-C) serves as the primary marker for cardiovascular diseases. Reports suggest that rice bran oil has antihyperlipidaemic properties. However, current evidence suggests that no single oil can provide the recommended dietary fat ratio. Hence the present study was undertaken in patients with hyperlipidaemia to study effects of substitution of the cooking oil with a blend of 80% rice bran oil and 20% safflower oil on LDL-C levels. The selected patients (n = 73) were randomly assigned either to the study oil group (blend under study) or control oil group (the oil which the patient was using before). The lipid profile was monitored monthly in these patients for 3 months during which they consumed the oil as per the randomisation. At each follow up, LDL-C levels showed a significant reduction from baseline in the study oil group and reduction was more than that observed in the control group. It was also observed that the percentage of the respondents was higher in the study oil group. At the end of the study period, 82% patients from this group had LDL levels less than 150 mg% as against 57% in the control group. Thus, the substitution of usual cooking oil with a blend of rice bran oil and safflower oil (8:2) was found to exert beneficial effects on the LDL-C levels shifting them to low-risk lipid category.

  7. The quantum double in integrable quantum field theory

    International Nuclear Information System (INIS)

    Bernard, D.; LeClair, A.

    1993-01-01

    Various aspects of recent works on affine quantum group symmetry of integrable 2D quantum field theory are reviewed and further clarified. A geometrical meaning is given to the quantum double, and other properties of quantum groups. The S-matrix is identified with the universal R-matrix. Multiplicative presentations of the yangian double are analyzed. (orig.)

  8. Comparison in myelography between iodixanol 270 and 320 mgI/ml and iotrolan 300 mgI/ml: a multicentre, randomised, parallel-group, double-blind, phase III trial

    International Nuclear Information System (INIS)

    Palmers, Yvan; Kuhn, Fritz-Peter; Petersen, Dirk; De Greef, Danielle

    2002-01-01

    The objective of the trial was to compare the safety and efficacy of the non-ionic, dimeric, isotonic contrast medium iodixanol (Visipaque 270 and 320 mgI/ml) with those of iotrolan (Isovist 300 mgI/ml) in myelography. After lumbar or cervical puncture, 315 patients were examined in a multicentre, double-blind, randomised, comparative myelography study. Image quality, changes in vital signs, immediate and delayed adverse events were registered. There was a tendency for better images with iodixanol 320 than with iodixanol 270 and iotrolan 300, but the overall quality was good or excellent with all products. The frequency of patients reporting adverse events and headache varied much across centres, but there was no statistically significant difference between the contrast media. The incidence of events was higher after lumbar puncture than after cervical puncture, in women rather than in men, and after puncture with a 22-gauge (G) bevel-tipped needle compared with a 24 G Sprotte needle. The frequency of headache did not correlate with the absence of pathology. The higher iodine concentration in iodixanol 320 could be an advantage for film quality. When compared with iotrolan 300, iodixanol 320 and 270 give similar incidences of adverse events, including headache. (orig.)

  9. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

    Science.gov (United States)

    Rascol, O; Brooks, D J; Melamed, E; Oertel, W; Poewe, W; Stocchi, F; Tolosa, E

    Rasagiline mesylate is a novel drug for Parkinson's disease with selective, irreversible monoamine oxidase B (MAO-B) inhibitor activity, and is effective as monotherapy in early disease. This study investigated rasagiline efficacy and safety in levodopa-treated patients with Parkinson's disease and motor fluctuations. In an 18-week, double-blind, multicentre (74 hospitals and academic centres in Israel, Argentina, and Europe) trial, 687 outpatients were randomly assigned to oral rasagiline (231 individuals; 1 mg once daily), entacapone (227; 200 mg with every levodopa dose), or placebo (229). Primary outcome was change in total daily off-time (intention-to-treat population). Other measures included the clinical global improvement (CGI) score and unified Parkinson's disease rating scale (UPDRS) scores. Analysis was by intention to treat. 88 (13%) patients who were assigned treatment did not complete the study (23 rasagiline, 30 entacapone, 35 placebo), mainly because of withdrawal of consent (n=34) and adverse events (n=34). Both rasagiline and entacapone reduced mean daily off-time (-1.18 h rasagiline and -1.2 h entacapone vs placebo -0.4 h; p=0.0001, prasagiline and -0.72 entacapone vs -0.37 placebo; prasagiline reduces mean daily off-time and improves symptoms of Parkinson's disease in levodopa-treated patients with motor fluctuations, an effect similar to that of entacapone.

  10. A randomized, double-blind, phase I/II trial of tumor necrosis factor and interferon-gamma for treatment of AIDS-related complex (Protocol 025 from the AIDS Clinical Trials Group).

    Science.gov (United States)

    Agosti, J M; Coombs, R W; Collier, A C; Paradise, M A; Benedetti, J K; Jaffe, H S; Corey, L

    1992-05-01

    To determine safety and efficacy of tumor necrosis factor (TNF) and interferon-gamma (IFN gamma) in the treatment of patients with acquired immunodeficiency syndrome (AIDS)-related complex, a randomized, double-blind study was conducted. Twenty-five patients with AIDS-related complex and CD4 lymphocytes less than or equal to 500 x 10(6)/L attended an AIDS Clinical Trials Unit of a tertiary referral center. Patients were administered tumor necrosis factor (TNF) (10 micrograms/m2) or IFN gamma (10 micrograms/m2), or both intramuscularly three times weekly for 16 weeks. Side effects from all three preparations included fever, constitutional symptoms, and local reactions. No significant hematologic, hepatic, renal, or coagulation abnormalities were observed. CD4 lymphocyte counts, beta 2-microglobulin, p24 antigen levels, and anti-p24 antibody did not change significantly during therapy. Similarly, no significant change was noted in rates of HIV isolation from peripheral blood mononuclear cells or plasma. TNF and IFN gamma were tolerable after premedication with acetaminophen; however, no significant change in markers of human immunodeficiency virus infection was demonstrated. These cytokines alone do not appear to be of benefit, nor do they appear to hasten the progression of HIV infection.

  11. Generation of new solutions of the stationary axisymmetric Einstein equations by a double complex function method

    International Nuclear Information System (INIS)

    Zhong, Z.

    1985-01-01

    A new approach to the solution of certain differential equations, the double complex function method, is developed, combining ordinary complex numbers and hyperbolic complex numbers. This method is applied to the theory of stationary axisymmetric Einstein equations in general relativity. A family of exact double solutions, double transformation groups, and n-soliton double solutions are obtained

  12. Congenital maxillary double lip

    Directory of Open Access Journals (Sweden)

    Dinesh Singh Chauhan

    2012-01-01

    Full Text Available Double lip, also referred to as "macrocheilia," is a rare anomaly which affects the upper lip more commonly than the lower lip. It consists of a fold of excess or redundant hypertrophic tissue on the mucosal side of the lip. The congenital double lip is believed to be present at birth and becomes more prominent after eruption of teeth. It affects esthetics and also interferes with speech and mastication. Simple surgical excision produces good functional and cosmetic results. We report a case of a non-syndromic congenital maxillary double lip in a 21-year-old male patient.

  13. A Randomized, Placebo-Controlled, Double-Blind, Parallel Groups Study Evaluating the Performance and Safety of a Steady State Coherent Biomodulator Patch in the Treatment of Subjective Tinnitus.

    Science.gov (United States)

    Ahnblad, Peter; Nordkvist, Anders

    2017-12-01

    The objectives of this study were to evaluate the performance and safety of an innovative passive light photon driven microscopic biomodulator patch as an alternative medical device for tinnitus relief. Eighty-two (82) patients were randomized to receive either an active (biomodulator) patch or a placebo patch, for a 3-week treatment period. Patch performance (evaluated with questionnaires related to tinnitus and quality-of-life) and safety were assessed after 3 weeks of treatment (Week 3) and at a follow-up visit 4-weeks after end of treatment (Week 7). The biomodulator patch was safe and well-tolerated and was efficacious, with significant difference (p < 0.05) between the groups at Week 7; active patch had 30% responders compared to 10% for placebo, measured as a decrease from baseline in at least 2 points in tinnitus annoyance visual analogue scale (VAS, 0-10). Tinnitus handicap inventory (THI, 0-100) improved by mean -16 points significantly (p = 0.0005) for the active responder group, but with no statistically significant changes for the placebo group or between the groups. Well-being questionnaire also improved for the active responder group, but not statistically significant. The placebo responder group did not improve in well-being. Other tinnitus related symptoms did not show significant changes. There was no statistically significant difference in performance between the active (biomodulator) and placebo groups directly at the end of treatment (Week 3). In a cost-risk-benefit rationale according to this study it can be reasonable to recommend the biomodulator patch for treatment of tinnitus. Improvements were shown at Week 7 (4 weeks after the end of treatment period).

  14. Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

    Science.gov (United States)

    Takasawa, Hironao; Suzuki, Hiroshi; Ogawa, Izumi; Shimada, Yasushi; Kobayashi, Kazuo; Terashima, Yukari; Matsumoto, Hirotaka; Oshida, Keiyu; Ohta, Ryo; Imamura, Tadashi; Miyazaki, Atsushi; Kawabata, Masayoshi; Minowa, Shigenori; Maeda, Akihisa; Hayashi, Makoto

    2010-04-30

    A collaborative study was conducted to evaluate whether a liver micronucleus assay using four-week-old male F344 rats can be used to detect genotoxic rat hepatocarcinogens using double-dosing with a single-sampling 4 days after the second dose. The assay methods were thoroughly validated by the seven laboratories involved in the study. Seven chemicals, 2,4-diaminotoluene, diethyl nitrosamine, p-dimethylaminoazobenzene, 1,2-dimethylhydrazine dihydrochloride, 2,4-dinitrotolunene, 2,6-dinitrotoluene and mitomycin C, known to produce positive responses in the single-dosing/triple-sampling method were selected for use in the present study, and each chemical was examined in two laboratories with the exception of 2,4-dinitrotolunene. Although several of the compounds were examined at lower doses for reasons of toxicity than in the single-dosing/triple-sampling method, all chemicals tested in the present study induced micronuclei in liver cells indicating a positive result. These findings suggest that the liver micronucleus assay can be used in young rats to detect genotoxic rat hepatocarcinogens using a double-dosing/single-sampling procedure. Further, the number of animals used in the liver micronucleus assay can be reduced by one-third to a half by using the double-dosing/single-sampling method. This reduction in animal numbers also has significant savings in time and resource for liver perfusion and hepatocyte isolation. Copyright 2010 Elsevier B.V. All rights reserved.

  15. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.

    Science.gov (United States)

    Murata, Yoko; Song, Michael; Kikuchi, Hisayuki; Hisamichi, Katsuya; Xu, Xie L; Greenspan, Andrew; Kato, Mai; Chiou, Chiun-Fang; Kato, Takeshi; Guzzo, Cynthia; Thurmond, Robin L; Ohtsuki, Mamitaro; Furue, Masutaka

    2015-02-01

    This trial was conducted to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult Japanese patients with moderate atopic dermatitis (AD). Eligible patients were randomly assigned to JNJ-39758979 300 mg, 100 mg or placebo once daily for 6 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study. Primary efficacy was assessed via week-6 Eczema Area and Severity Index (EASI) scores. Secondary efficacy assessments included Investigator's Global Assessment (IGA) and patient-reported outcome (PRO) pruritus assessments (Pruritus Categorical Response Scale [PCRS], Pruritus Numeric Rating Scales [PNRS], Pruritus Interference Numeric Rating Scale [PINRS] and Subject's Global Impressions of Change in Pruritus [SGICP]). Eighty-eight of 105 planned patients were randomized before the study was stopped and unblinded for safety reasons. The study did not meet the primary end-point. However, numerical improvements (i.e. decreases) in median EASI were observed with JNJ-39758979 100 mg (-3.7) and 300 mg (-3.0) versus placebo (-1.3) at week 6. Nominally significant improvements across PRO PCRS, PNRS and SGICP assessments were consistently observed, particularly with JNJ-39758979 300 mg. Safety, including adverse events (AE), was comparable between JNJ-39758979 and placebo with the exception of two patients (both receiving JNJ-39758979 300 mg) with serious AE of neutropenia, leading to premature study discontinuation. No deaths were reported. Except for neutropenia, no clinically relevant changes in laboratory values were observed. Although not conclusive, findings suggest H4 R-antagonism may be beneficial for AD, particularly in controlling pruritus. JNJ-39758979 appears to be associated with drug-induced agranulocytosis, likely an off-target effect. © 2014 Japanese Dermatological Association.

  16. Efficacy and safety of 1 % terbinafine film-forming solution in Chinese patients with tinea pedis: a randomized, double-blind, placebo-controlled, multicenter, parallel-group study.

    Science.gov (United States)

    Li, Ruo Yu; Wang, A P; Xu, J H; Xi, L Y; Fu, M H; Zhu, M; Xu, M L; Li, X Q; Lai, W; Liu, W D; Lu, X Y; Gong, Z Q

    2014-03-01

    Superficial fungal skin infections are treated using topical antifungals. The aim of this study was to demonstrate the efficacy of a single application of 1 % terbinafine film-forming solution (FFS) versus placebo for the treatment of tinea pedis in the Chinese population. Six centers in China randomized 290 patients in a 1:1 ratio to receive either 1 % terbinafine FFS or FFS vehicle (placebo) once on the affected foot/feet. Efficacy assessments included microscopy and mycologic culture, and assessing clinical signs and symptoms at baseline, and at weeks 1 and 6 after the topical treatment. All adverse events were recorded. At week 6, 1 % terbinafine FFS was superior to placebo for effective treatment rate (63 vs. 8 %); clinical cure (30 vs. 6 %); mycological cure (86 vs. 12 %); negative microscopy (90 vs. 24 %); and negative mycological culture (90 vs. 27 %): all p ≤ 0.001 and clinically relevant. At week 6, 1 % terbinafine FFS was clinically superior to placebo for the absence of: erythema (69 vs. 29 %); desquamation (33 vs. 8 %); and pruritus (70 vs. 30 %): all p ≤ 0.001 and clinically relevant. At week 6, differences in the average total signs and symptoms scores were significantly lower for 1 % terbinafine FFS versus placebo (p ≤ 0.001). Both 1 % terbinafine FFS and placebo were safe and well tolerated based on adverse events and investigator and patient assessments. This double-blind, randomized, multicenter study demonstrated one single topical application of 1 % terbinafine FFS was safe and effective in the treatment of tinea pedis in the Chinese population.

  17. Pion double charge exchange

    International Nuclear Information System (INIS)

    Cooper, M.D.

    1978-01-01

    The pion double charge exchange data on the oxygen isotopes is reviewed and new data on 9 Be, 12 C, 24 Mg, and 28 Si are presented. Where theoretical calculations exist, they are compared to the data. 9 references

  18. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    2012-10-06

    Oct 6, 2012 ... Anyhow, the 'multi-isotope' ansatz is needed to compensate for matrix element ... The neccessary half-life requirement to touch this ... site energy depositions (like double beta decay) and multiple site interactions (most of.

  19. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Ehlers, Michael; Adland, Karoline Thorp

    activities carried out within the framework of the projects. The formal part of Project Half Double was initiated in June 2015. We started out by developing, refining and testing the Half Double methodology on seven pilot projects in the first phase of the project, which will end June 2016. The current......Project Half Double has a clear mission to succeed in finding a project methodology that can increase the success rate of our projects while increasing the speed at which we generate new ideas and develop new products and services. Chaos and complexity should be seen as a basic condition...... and as an opportunity rather than a threat and a risk. We are convinced that by doing so, we can strengthen Denmark’s competitiveness and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “projects in half the time with double the impact”, where projects in half the time...

  20. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Gerstrøm, Anna; Frederiksen, Signe Hedeboe

    The Half Double mission: Project Half Double has a clear mission. We want to succeed in finding a project methodology that can increase the success rate of our projects while increasing the development speed of new products and services. We are convinced that by doing so we can strengthen...... the competitiveness of Denmark and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “Projects in half the time with double the impact” where projects in half the time should be understood as half the time to impact (benefit realization, effect is achieved......) and not as half the time for project execution. The Half Double project journey: It all began in May 2013 when we asked ourselves: How do we create a new and radical project paradigm that can create successful projects? Today we are a movement of hundreds of passionate project people, and it grows larger...

  1. Double beta decay: experiments

    International Nuclear Information System (INIS)

    Fiorini, Ettore

    2006-01-01

    The results obtained so far and those of the running experiments on neutrinoless double beta decay are reviewed. The plans for second generation experiments, the techniques to be adopted and the expected sensitivities are compared and discussed

  2. A double layer review

    International Nuclear Information System (INIS)

    Block, L.P.

    1977-06-01

    A review of the main results on electrostatic double layers (sometimes called space charge layers or sheaths) obtained from theory, and laboratory and space experiments up to the spring of 1977 is given. By means of barium jets and satellite probes, double layers have now been found at the altitudes, earlier predicted theoretically. The general potential distribution above the auroral zone, suggested by inverted V-events and electric field reversals, is corroborated. (author)

  3. A 6-week, multicenter, randomized, double-masked, parallel-group study comparing travoprost 0.004% to latanoprost 0.005% followed by 6-week, open-label treatment with travoprost 0.004%.

    Science.gov (United States)

    Maul, Eugenio; Carrasco, Félix Gil; Costa, Vital Paulino; Casiraghi, Javier F; Vargas, Enrique; Sarmina, Judith S; Mayol, Renato

    2007-09-01

    The aim of this study was to compare the tolerability and efficacy of once-daily travoprost 0.004% versus latanoprost 0.005% for 6 weeks followed by 6 weeks of once-daily travoprost 0.004% in decreasing intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OH). This multicenter, randomized, doublemasked, active-controlled, parallel-group trial was conducted at 32 centers across Latin America. Patients aged > or =18 years with OAG or OH were randomly assigned to receive topical travoprost 0.004% or latanoprost 0.005% 1 drop QD (9 PM) for 6 weeks (masked phase). At 6 weeks, all patients were assigned to receive open-label travoprost 0.004% 1 drop QD (9 PM) for 6 additional weeks (open-label phase). Study visits were scheduled at weeks 1, 2, 4, 6, 8, and 12. At each study visit, IOP was measured at 5 PM (+/-1 hour; approximately 20 hours after study drug administration). IOP changes from baseline were combined (pooled) from the 1-, 2-, 4-, and 6-week data to provide a comparison between the 2 treatment groups. Ocular adverse events (AEs) were monitored using slit-lamp examination. A total of 302 patients were enrolled (travoprost group, 155 patients; latanoprost group, 147 patients). The mean (SD) age of the travoprost group was 61.9 (10.6) years; 60.6% were female; and 47.1% were white. The mean (SD) age of the latanoprost group was 60.5 (12.4) years; 62.6% were female; and 49.0% were white. Mean IOP values were not significantly different between the travoprost and latanoprost groups at baseline (24.7 vs 24.2 mm Hg) or 6 weeks; however, the between-group difference in reductions from baseline in pooled IOP during the masked phase of the study was statistically significant (-8.3 vs -7.5 mm Hg; P = 0.009). At weeks 6 and 12, mean lOP levels were 16.1 and 16.2 mm Hg, respectively, in the travoprost group and 16.4 and 16.1 mm Hg in the group that was switched from latanoprost to travoprost (all, P = NS). The most common ocular AEs

  4. Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study.

    Science.gov (United States)

    Higashi, Yoshinobu; Kiuchi, Takehito; Furuta, Kenichi

    2010-01-01

    An occlusive patch formulation containing 10% methyl salicylate and 3% l-menthol was recently approved by the US Food and Drug Administration for the treatment of mild to moderate pain. Despite widespread use of counterirritants, including methyl salicylate and menthol, for topical pain relief, published efficacy and safety data regarding the use of the agents alone or in combination are limited. The goal of this study was to determine the efficacy and safety profile of a patch containing 10% methyl salicylate and 3% l-menthol compared with a placebo patch in adult patients with mild to moderate muscle strain. Eligible patients were men or women aged >or=18 years with a clinical diagnosis of mild to moderate muscle strain. Patients were randomly assigned to receive either 1 active patch or 1 placebo patch applied to the skin at the affected area (ie, shoulder, upper back, upper arm, neck, calf, thigh, forearm, abdomen). Pain intensity was assessed on a 100-mm visual analog scale while at rest and with movement for 12 hours after patch application. The primary efficacy end point was the summed pain intensity difference score through 8 hours (SPID8) with movement. Analyses included use of descriptive statistics and an ANOVA model. Safety data, including adverse events, and secondary efficacy end points were also evaluated. A total of 208 patients (104 men, 104 women; age range, 18-78 years) were randomized to 1 of 2 study groups (105 in the active-patch group [mean age, 37.3 years], 103 in the placebo-patch group [mean age, 38.1 years]). The primary efficacy analysis (SPID8 with movement) indicated that patients receiving the active patch experienced significantly greater pain relief (approximately 40%) than those patients receiving a placebo patch (mean [SD], 182.6 [131.2] vs 130.1 [144.1]; P = 0.005). Analysis of the per-protocol population also found significantly more relief (P = 0.024) in the active-patch group (176.2 [131.4]; n = 92) versus the placebo

  5. Aristotle and Double Effect

    DEFF Research Database (Denmark)

    Di Nucci, Ezio

    2014-01-01

    There are some interesting similarities between Aristotle’s ‘mixed actions’ in Book III of the Nicomachean Ethics and the actions often thought to be justifiable with the Doctrine of Double Effect. Here I analyse these similarities by comparing Aristotle’s examples of mixed actions with standard...... cases from the literature on double effect such as, amongst others, strategic bombing, the trolley problem, and craniotomy. I find that, despite some common features such as the dilemmatic structure and the inevitability of a bad effect, Aristotle’s mixed actions do not count as cases justifiable...... through application of the Doctrine of Double Effect because they fail to meet the crucial necessary condition of the Doctrine according to which the bad effect can only be a merely foreseen side- effect and not an intended means....

  6. Coulomb double helical structure

    Science.gov (United States)

    Kamimura, Tetsuo; Ishihara, Osamu

    2012-01-01

    Structures of Coulomb clusters formed by dust particles in a plasma are studied by numerical simulation. Our study reveals the presence of various types of self-organized structures of a cluster confined in a prolate spheroidal electrostatic potential. The stable configurations depend on a prolateness parameter for the confining potential as well as on the number of dust particles in a cluster. One-dimensional string, two-dimensional zigzag structure and three-dimensional double helical structure are found as a result of the transition controlled by the prolateness parameter. The formation of stable double helical structures resulted from the transition associated with the instability of angular perturbations on double strings. Analytical perturbation study supports the findings of numerical simulations.

  7. John Deakin: Double Exposures

    Directory of Open Access Journals (Sweden)

    Paul Rousseau

    2015-11-01

    Full Text Available In this series of short films made by Jonathan Law, the art historian James Boaden, and the curator of The John Deakin Archive, Paul Rousseau, discuss the double-exposure images made by the photographer John Deakin (1912-1972 in the 1950s and 1960s. The films ask you, firstly, to look closely at the images being discussed. Each one begins with a sustained and intense shot of a single image before opening up to a wide-ranging discussion about Deakin, double exposures, and photography.

  8. Double Photoionization Near Threshold

    Science.gov (United States)

    Wehlitz, Ralf

    2007-01-01

    The threshold region of the double-photoionization cross section is of particular interest because both ejected electrons move slowly in the Coulomb field of the residual ion. Near threshold both electrons have time to interact with each other and with the residual ion. Also, different theoretical models compete to describe the double-photoionization cross section in the threshold region. We have investigated that cross section for lithium and beryllium and have analyzed our data with respect to the latest results in the Coulomb-dipole theory. We find that our data support the idea of a Coulomb-dipole interaction.

  9. Double Chooz experiment

    International Nuclear Information System (INIS)

    Palomares, C.

    2009-01-01

    Double Chooz will use two identical detectors at different distances from the Chooz nuclear power station to search for a non-vanishing value of θ 13 , and, hopefully, to open the way to experiments aspiring to discover CP violation in the leptonic sector. The far detector is expected to be operative by the end of 2009. Installation of the near detector will occur in 2010. Double Chooz has the capacity to exclude sin 2 (2θ 13 ) 31 2 = 2.5 x 10 -3 eV 2 with three years of data running both near and far detectors. (author)

  10. Double-helix stellarator

    International Nuclear Information System (INIS)

    Moroz, P.E.

    1997-09-01

    A new stellarator configuration, the Double-Helix Stellarator (DHS), is introduced. This novel configuration features a double-helix center post as the only helical element of the stellarator coil system. The DHS configuration has many unique characteristics. One of them is the extreme low plasma aspect ratio, A ∼ 1--1.2. Other advantages include a high enclosed volume, appreciable rotational transform, and a possibility of extreme-high-β MHD equilibria. Moreover, the DHS features improved transport characteristics caused by the absence of the magnetic field ripple on the outboard of the torus. Compactness, simplicity and modularity of the coil system add to the DHS advantages for fusion applications

  11. A prospective, randomised, controlled, double-blind phase I-II clinical trial on the safety of A-Part® Gel as adhesion prophylaxis after major abdominal surgery versus non-treated group

    Directory of Open Access Journals (Sweden)

    Weis Christine

    2010-07-01

    Full Text Available Abstract Background Postoperative adhesions occur when fibrous strands of internal scar tissue bind anatomical structures to one another. The most common cause of intra-abdominal adhesions is previous intra-abdominal surgical intervention. Up to 74% of intestinal obstructions are caused by post surgical adhesions. Although a variety of methods and agents have been investigated to prevent post surgical adhesions, the problem of peritoneal adhesions remains largely unsolved. Materials serving as an adhesion barrier are much needed. Methods/Design This is a prospective, randomised, controlled, patient blinded and observer blinded, single centre phase I-II trial, which evaluates the safety of A-Part® Gel as an adhesion prophylaxis after major abdominal wall surgery, in comparison to an untreated control group. 60 patients undergoing an elective median laparotomy without prior abdominal surgery are randomly allocated into two groups of a 1:1- ratio. Safety parameter and primary endpoint of the study is the occurrence of wound healing impairment or peritonitis within 28 (+10 days after surgery. The frequency of anastomotic leakage within 28 days after operation, occurrence of adverse and serious adverse events during hospital stay up to 3 months and the rate of adhesions along the scar within 3 months are defined as secondary endpoints. After hospital discharge the investigator will examine the enrolled patients at 28 (+10 days and 3 months (±14 days after surgery. Discussion This trial aims to assess, whether the intra-peritoneal application of A-Part® Gel is safe and efficacious in the prevention of post-surgical adhesions after median laparotomy, in comparison to untreated controls. Trial registration NCT00646412

  12. Biomechanical evaluation of knotless anatomical double-layer double-row rotator cuff repair: a comparative ex vivo study.

    Science.gov (United States)

    Hepp, Pierre; Osterhoff, Georg; Engel, Thomas; Marquass, Bastian; Klink, Thomas; Josten, Christoph

    2009-07-01

    The layered configuration of the rotator cuff tendon is not taken into account in classic rotator cuff tendon repair techniques. The mechanical properties of (1) the classic double-row technique, (2) a double-layer double-row (DLDR) technique in simple suture configuration, and (3) a DLDR technique in mattress suture configuration are significantly different. Controlled laboratory study. Twenty-four sheep shoulders were assigned to 3 repair groups of full-thickness infraspinatus tears: group 1, traditional double-row repair; group 2, DLDR anchor repair with simple suture configuration; and group 3, DLDR knotless repair with mattress suture configuration. After ultrasound evaluation of the repair, each specimen was cyclically loaded with 10 to 100 N for 50 cycles. Each specimen was then loaded to failure at a rate of 1 mm/s. There were no statistically significant differences among the 3 testing groups for the mean footprint area. The cyclic loading test revealed no significant difference among the 3 groups with regard to elongation. For the load-to-failure test, groups 2 and 3 showed no differences in ultimate tensile load when compared with group 1. However, when compared to group 2, group 3 was found to have significantly higher values regarding ultimate load, ultimate elongation, and energy absorbed. The DLDR fixation techniques may provide strength of initial repair comparable with that of commonly used double-row techniques. When compared with the knotless technique with mattress sutures, simple suture configuration of DLDR repair may be too weak. Knotless DLDR rotator cuff repair may (1) restore the footprint by the use of double-row principles and (2) enable restoration of the shape and profile. Double-layer double-row fixation in mattress suture configuration has initial fixation strength comparable with that of the classic double-row fixation and so may potentially improve functional results of rotator cuff repair.

  13. Gauge symmetry, T-duality and doubled geometry

    Energy Technology Data Exchange (ETDEWEB)

    Hull, C.M. [Imperial College London (United Kingdom). Inst. for Mathematical Sciences]|[Imperial College London (United Kingdom). Blackett Laboratory; Reid-Edwards, R.A. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik]|[Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2007-11-15

    String compactifications with T-duality twists are revisited and the gauge algebra of the dimensionally reduced theories calculated. These reductions can be viewed as string theory on T-fold backgrounds, and can be formulated in a 'doubled space' in which each circle is supplemented by a T-dual circle to construct a geometry which is a doubled torus bundle over a circle. We discuss a conjectured extension to include T-duality on the base circle, and propose the introduction of a dual base coordinate, to give a doubled space which is locally the group manifold of the gauge group. Special cases include those in which the doubled group is a Drinfel'd double. This gives a framework to discuss backgrounds that are not even locally geometric. (orig.)

  14. Gauge symmetry, T-duality and doubled geometry

    International Nuclear Information System (INIS)

    Hull, C.M.

    2007-11-01

    String compactifications with T-duality twists are revisited and the gauge algebra of the dimensionally reduced theories calculated. These reductions can be viewed as string theory on T-fold backgrounds, and can be formulated in a 'doubled space' in which each circle is supplemented by a T-dual circle to construct a geometry which is a doubled torus bundle over a circle. We discuss a conjectured extension to include T-duality on the base circle, and propose the introduction of a dual base coordinate, to give a doubled space which is locally the group manifold of the gauge group. Special cases include those in which the doubled group is a Drinfel'd double. This gives a framework to discuss backgrounds that are not even locally geometric. (orig.)

  15. Double aortic arch

    Science.gov (United States)

    Surgery can be done to fix double aortic arch. The surgeon ties off the smaller branch and separates it from the larger branch. Then the surgeon closes the ends of the aorta with stitches. This relieves pressure on the esophagus and windpipe.

  16. Singapore's double festival

    Energy Technology Data Exchange (ETDEWEB)

    Fraser, Gordon

    1990-09-15

    Coinciding with celebrations for the nation's 25th anniversary, the 25th International Conference on High Energy Physics, held in Singapore from 2-8 August, was itself a double festival, with the Standard Model of contemporary physics and CERN's new LEP electron-positron collider providing the twin themes.

  17. Layered double hydroxides

    DEFF Research Database (Denmark)

    López Rayo, Sandra; Imran, Ahmad; Hansen, Hans Chr. Bruun

    2017-01-01

    A novel zinc (Zn) fertilizer concept based on Zn doped layered double hydroxides (Zn-doped Mg-Fe-LDHs) has been investigated. Zn-doped Mg-Fe-LDHs were synthetized, their chemical composition was analyzed and their nutrient release was studied in buffered solutions with different pH values. Uptake...

  18. Double Beta Decay Experiments

    International Nuclear Information System (INIS)

    Piepke, A.

    2005-01-01

    The experimental observation of neutrino oscillations and thus neutrino mass and mixing gives a first hint at new particle physics. The absolute values of the neutrino mass and the properties of neutrinos under CP-conjugation remain unknown. The experimental investigation of the nuclear double beta decay is one of the key techniques for solving these open problems

  19. Identification and Multiplicity of Double Vowels in Cochlear Implant Users

    Science.gov (United States)

    Kwon, Bomjun J.; Perry, Trevor T.

    2014-01-01

    Purpose: The present study examined cochlear implant (CI) users' perception of vowels presented concurrently (i.e., "double vowels") to further our understanding of auditory grouping in electric hearing. Method: Identification of double vowels and single vowels was measured with 10 CI subjects. Fundamental frequencies (F0s) of…

  20. Double quantum dot as a minimal thermoelectric generator

    OpenAIRE

    Donsa, S.; Andergassen, S.; Held, K.

    2014-01-01

    Based on numerical renormalization group calculations, we demonstrate that experimentally realized double quantum dots constitute a minimal thermoelectric generator. In the Kondo regime, one quantum dot acts as an n-type and the other one as a p-type thermoelectric device. Properly connected the double quantum dot provides a miniature power supply utilizing the thermal energy of the environment.

  1. Cure of Helicobacter pylori-positive active duodenal ulcer patients: a double-blind, multicentre, 12-month study comparing a two-week dual vs a one-week triple therapy. GISU (Interdisciplinary Group for Ulcer Study).

    Science.gov (United States)

    Di Mario, F; Battaglia, F; Dal Bò, N; Leandro, G; Benedetti, E; Bottona, E; Caroli, A; Costan-Biedo, F; De Bastiani, R; Germanà, B; Andrea Grassi, S; Madia, D; Marcon, V; Marin, R; Monica, F; Olivieri, P; Orzes, N; Pilotto, A; Ronzani, G; Saggioro, A; Tafner, G

    2000-03-01

    To compare a two-week dual therapy to a one-week triple therapy for the healing of duodenal ulcer and the eradication of the Helicobacter pylori infection. A total of 165 patients with active duodenal ulcer were enrolled in the study. At entry, endoscopy, clinical examination and laboratory tests were performed. Histology and the rapid urease test were used to diagnose Helicobacter pylori infection. Patients received either lansoprazole 30 mg plus amoxycillin 1 g bid for two weeks (two-week, dual therapy) or lansoprazole 30 mg plus amoxycillin 1 g plus tinidazole 500 mg bid for one week plus lansoprazole qd for an additional week (one-week, triple therapy). Two and twelve months after cessation of therapy, endoscopy and clinical assessments were repeated. Duodenal ulcer healing and Helicobacter pylori eradication were both significantly greater (pcure rate: 72.6%) than in the dual therapy group (healing: 77.3%; Helicobacter pylori cure rate: 33.3%). Ulcers healed more frequently in Helicobacter pyloricured than in Helicobacter pylori-not cured patients (94.9% vs. 77.2%; pulcer relapses were observed throughout follow-up: all were in Helicobacter pylori-not cured patients. Triple therapy was more effective than dual both in curing Helicobacter pylori infection and healing active duodenal ulcers. The speed of ulcer healing obtained after only 7 days of antibiotics and 14 days of proton pump inhibitors confirmed that longer periods of anti ulcer therapy were not necessary. Helicobacter pylori -not cured patients had more slowly healing ulcers which were more apt to relapse when left untreated.

  2. Early (≤ 1-h) vs. late (>1-h) administration of frovatriptan plus dexketoprofen combination vs. frovatriptan monotherapy in the acute treatment of migraine attacks with or without aura: a post hoc analysis of a double-blind, randomized, parallel group study.

    Science.gov (United States)

    Allais, Gianni; Bussone, Gennaro; Tullo, Vincenzo; Cortelli, Pietro; Valguarnera, Fabio; Barbanti, Piero; Sette, Giuliano; Frediani, Fabio; D'Arrigo, Giacomo; d'Onofrio, Florindo; Comi, Giancarlo; Curone, Marcella; Colombo, Bruno; Omboni, Stefano; Benedetto, Chiara

    2015-05-01

    The early use of triptan in combination with a nonsteroidal anti-inflammatory drug after headache onset may improve the efficacy of acute migraine treatment. In this retrospective analysis of a randomized, double-blind, parallel group study, we assessed the efficacy of early or late intake of frovatriptan 2.5 mg + dexketoprofen 25 or 37.5 mg (FroDex 25 and FroDex 37.5) vs. frovatriptan 2.5 mg alone (Frova) in the acute treatment of migraine attacks. In this double-blind, randomized parallel group study 314 subjects with acute migraine with or without aura were randomly assigned to Frova, FroDex 25, or FroDex 37.5. Pain free (PF) at 2-h (primary endpoint), PF at 4-h and pain relief (PR) at 2 and 4-h, speed of onset at 60, 90, 120 and 240-min, and sustained pain free (SPF) at 24-h were compared across study groups according to early (≤1-h; n = 220) or late (>1-h; n = 59) intake. PF rates at 2 and 4-h were significantly larger with FroDex 37.5 vs. Frova (early intake, n = 71 FroDex 37.5 and n = 75 Frova: 49 vs. 32 % and 68 vs. 52 %, p < 0.05; late intake, n = 20 Frodex 37.5, and n = 18 Frova: 55 vs. 17 %, p < 0.05 and 85 vs. 28 %, p < 0.01). Also with FroDex 25, in the early intake group (n = 74) PF episodes were significantly higher than Frova. PR at 2 and 4-h was significantly better under FroDex 37.5 than Frova (95 % vs. 50 %, p < 0.001, 100 % vs. 72 %, p < 0.05) in the late intake group (n = 21). SPF episodes at 24-h after early dosing were 25 % (Frova), 45 % (FroDex 25) and 41 % (FroDex 37.5, p < 0.05 combinations vs. monotherapy), whereas they were not significantly different with late intake. All treatments were equally well tolerated. FroDex was similarly effective regardless of intake timing from headache onset.

  3. Space-Time Crystal and Space-Time Group.

    Science.gov (United States)

    Xu, Shenglong; Wu, Congjun

    2018-03-02

    Crystal structures and the Bloch theorem play a fundamental role in condensed matter physics. We extend the static crystal to the dynamic "space-time" crystal characterized by the general intertwined space-time periodicities in D+1 dimensions, which include both the static crystal and the Floquet crystal as special cases. A new group structure dubbed a "space-time" group is constructed to describe the discrete symmetries of a space-time crystal. Compared to space and magnetic groups, the space-time group is augmented by "time-screw" rotations and "time-glide" reflections involving fractional translations along the time direction. A complete classification of the 13 space-time groups in one-plus-one dimensions (1+1D) is performed. The Kramers-type degeneracy can arise from the glide time-reversal symmetry without the half-integer spinor structure, which constrains the winding number patterns of spectral dispersions. In 2+1D, nonsymmorphic space-time symmetries enforce spectral degeneracies, leading to protected Floquet semimetal states. We provide a general framework for further studying topological properties of the (D+1)-dimensional space-time crystal.

  4. Double-partition Quantum Cluster Algebras

    DEFF Research Database (Denmark)

    Jakobsen, Hans Plesner; Zhang, Hechun

    2012-01-01

    A family of quantum cluster algebras is introduced and studied. In general, these algebras are new, but sub-classes have been studied previously by other authors. The algebras are indexed by double parti- tions or double flag varieties. Equivalently, they are indexed by broken lines L. By grouping...... together neighboring mutations into quantum line mutations we can mutate from the cluster algebra of one broken line to another. Compatible pairs can be written down. The algebras are equal to their upper cluster algebras. The variables of the quantum seeds are given by elements of the dual canonical basis....

  5. Search for Neutrinoless Double-Beta Decay

    OpenAIRE

    Tornow, Werner

    2014-01-01

    After the pioneering work of the Heidelberg-Moscow (HDM) and International Germanium Experiment (IGEX) groups, the second round of neutrinoless double-$\\beta$ decay searches currently underway has or will improve the life-time limits of double-$\\beta$ decay candidates by a factor of two to three, reaching in the near future the $T_{1/2} = 3 \\times 10^{25}$ yr level. This talk will focus on the large-scale experiments GERDA, EXO-200, and KamLAND-Zen, which have reported already lower half-life...

  6. [Social crisis, spontaneous groups and group order].

    Science.gov (United States)

    Edelman, Lucila; Kordon, Diana

    2002-12-01

    Argentina has gone through very difficult times during the last years and, in particularly, new kinds of social practices have emerged in order to cope with the crisis. This situation demands and urges a new type of reflection upon the double role of groups, as tools to transform reality and as a way to elaborate those processes regarding subjectivity. In this paper we analyse some topics regarding the groupal field (considering spontaneous groups as well as groupal devices that allow to elaborate the crisis). We consider social bond to be the condition of possibility for the existence of the psyche and of time continuity, and that it also makes possible personal and social elaboration of trauma, crisis and social catastrophe. We develop some aspects of an specific device (the reflection group), which we have already depicted in another moment, showing it's usefulness to cope with social crisis and to promote the subjective elaboration of crisis.

  7. Opechowski's theorem and commutator groups

    International Nuclear Information System (INIS)

    Caride, A.O.; Zanette, S.I.

    1985-01-01

    It is shown that the conditions of application of Opechowski's theorem for double groups of subgroups of O(3) are directly associated to the structure of their commutator groups. Some characteristics of the structure of classes are also discussed. (Author) [pt

  8. How I treat double-hit lymphoma.

    Science.gov (United States)

    Friedberg, Jonathan W

    2017-08-03

    The 2016 revision of the World Health Organization (WHO) classification for lymphoma has included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed high-grade B-cell lymphoma with translocations involving myc and bcl-2 or bcl-6 . These lymphomas, which occur in hit lymphomas (or triple-hit lymphomas if all 3 rearrangements are present). It is important to differentiate these lymphomas from the larger group of double-expressor lymphomas, which have increased expression of MYC and BCL-2 and/or BCL-6 by immunohistochemistry, by using variable cutoff percentages to define positivity. Patients with double-hit lymphomas have a poor prognosis when treated with standard chemoimmunotherapy and have increased risk of central nervous system involvement and progression. Double-hit lymphomas may arise as a consequence of the transformation of the underlying indolent lymphoma. There are no published prospective trials in double-hit lymphoma, however retrospective studies strongly suggest that aggressive induction regimens may confer a superior outcome. In this article, I review my approach to the evaluation and treatment of double-hit lymphoma, with an eye toward future clinical trials incorporating rational targeted agents into the therapeutic armamentarium. © 2017 by The American Society of Hematology.

  9. Subatmospheric double containment system

    International Nuclear Information System (INIS)

    Gans, D. Jr.; Noble, J.H.

    1978-01-01

    A reinforced concrete double wall nuclear containment structure with each wall including an essentially impervious membrane or liner and porous concrete filling the annulus between the two walls is described. The interior of the structure is maintained at subatmospheric pressure, and the annulus between the two walls is maintained at a subatmospheric pressure intermediate between that of the interior and the surrounding atmospheric pressure, during normal operation. In the event of an accident within the containment structure the interior pressure may exceed atmospheric pressure, but leakage from the interior to the annulus between the double walls will not result in the pressure of the annulus exceeding atmospheric pressure so that there is no net outleakage from the containment structure

  10. Double rupture disc experience

    International Nuclear Information System (INIS)

    1979-01-01

    Result of these observations, comparisons and evaluations can be summarized in the following list of concerns regarding the use of double rupture discs coupled to the liquid space of a steam generator that is subjected to a large leak sodium water reaction event. Single rupture disc show delayed collapse characteristics in LLTR Series I and double disc assemblies are presumed to be more complex with additional delay before opening to give pressure relief. Delayed failure increases pressures in the IHTS and must be adequately covered by design requirements. With CRBR design, the first disc may fail only partially reducing the loading on the second disc with the result that relief performance may not meet requirements

  11. Gravitational double layers

    International Nuclear Information System (INIS)

    Senovilla, José M M

    2014-01-01

    I analyze the properties of thin shells through which the scalar curvature R is discontinuous in gravity theories with Lagrangian F(R) = R − 2Λ + αR 2 on the bulk. These shells/domain walls are of a new kind because they possess, in addition to the standard energy–momentum tensor, an external energy flux vector, an external scalar pressure/tension and, most exotic of all, another energy–momentum contribution resembling classical dipole distributions on a shell: a double layer. I prove that all these contributions are necessary to make the entire energy–momentum tensor divergence-free. This is the first known occurrence of such a type of double layer in a gravity theory. I present explicit examples in constant-curvature five-dimensional bulks, with a brief study of their properties: new physical behaviors arise. (fast track communications)

  12. The double Laplacian growth

    International Nuclear Information System (INIS)

    Loutsenko, I.; Yermolayeva, O.

    2008-06-01

    The dynamics of the idealized Laplacian growth (or the Hele-Shaw problem) can be approximated by the Poiselle flow which in appropriate units takes the form of the Darcy law. In this paper we account for the liquid inertia in the Hele-Shaw problem at zero surface tension limit. The Laplace dynamics for the pressure is extended here with one more for the velocity potential for which we call this growth process the Double Laplacian. The application of the conformal mappings technique leads to doubled dynamics for both the conformal map and the complex potential, which is presented in the paper for the radial and the planar growth. We apply the stability analysis and discuss the integrability for the stated problem. (author)

  13. Algebra of Majorana doubling.

    Science.gov (United States)

    Lee, Jaehoon; Wilczek, Frank

    2013-11-27

    Motivated by the problem of identifying Majorana mode operators at junctions, we analyze a basic algebraic structure leading to a doubled spectrum. For general (nonlinear) interactions the emergent mode creation operator is highly nonlinear in the original effective mode operators, and therefore also in the underlying electron creation and destruction operators. This phenomenon could open up new possibilities for controlled dynamical manipulation of the modes. We briefly compare and contrast related issues in the Pfaffian quantum Hall state.

  14. Twisted quantum doubles

    Directory of Open Access Journals (Sweden)

    Daijiro Fukuda

    2004-01-01

    Full Text Available Using diagrammatic pictures of tensor contractions, we consider a Hopf algebra (Aop⊗ℛλA** twisted by an element ℛλ∈A*⊗Aop corresponding to a Hopf algebra morphism λ:A→A. We show that this Hopf algebra is quasitriangular with the universal R-matrix coming from ℛλ when λ2=idA, generalizing the quantum double construction which corresponds to the case λ=idA.

  15. Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial.

    Science.gov (United States)

    Cho, Young-Gyu; Jung, Ji-Hye; Kang, Jae-Heon; Kwon, Jin Soo; Yu, Seung Pil; Baik, Tae Gon

    2017-07-28

    YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate the efficacy and safety of YY-312 for body fat reduction in overweight adults. This was a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial performed in overweight Korean adults aged 19-60 years with a body mass index of 25.0-29.9 kg/m 2 . The daily dose of YY-312 was 2400 mg (containing 1800 mg of active herbal extract and 600 mg of cyclodextrin). Primary outcomes were reductions in body fat mass (BFM) and body fat percentage (BF%) after 12 weeks. Secondary outcomes included reductions in body weight and waist circumference (WC) after 12 weeks. After 12 weeks, BFM (1.6 kg vs. 0.1 kg; P = 0.023) and BF% (1.5% vs. -0.2%; P = 0.018) decreased significantly more in the YY-312 group than in the placebo group, as did body weight (2.7 kg vs. 1.0 kg; P = 0.014) and WC (2.2 cm vs. 0.8 cm; P = 0.049). All safety parameters were within normal limits; no serious adverse events occurred in either group. In a 12-week clinical trial in overweight adults, YY-312 resulted in significantly greater reduction in body fat vs. placebo, while being safe and well tolerated. cris.nih.go.kr: ( KCT0001225 ).

  16. Singular solutions of renormalization group equations and the symmetry of the lagrangian

    International Nuclear Information System (INIS)

    Kazakov, D.I.; Shirokov, D.V.

    1975-01-01

    On the basis of solution of the differential renormalization group equations the method is proposed for finding out the Lagrangians possessing some king of internal symmetry. It is shown that in the phase space of the invariant charges the symmetry corresponds to the straight-line singular solution of these equations remaining straight-line when taking into account the higher order corrections. We have studied the model of scalar fields with quartic couplings, as well as the set of models containing scalar, pseudoscalar and spinor fields with Yukawa and quartic interactions. Straight-line singular solutions in the first case correspond to isotopic symmetry only. For the second case they correspond to supersymmetry. No other symmetries have been discovered. For the model containing the gauge fields the solution corresponding to supersymmetry is obtained and it is shown that this is also the only symmetry that can be realized in the given set of fields

  17. Dynamical diffusion and renormalization group equation for the Fermi velocity in doped graphene

    International Nuclear Information System (INIS)

    Ardenghi, J.S.; Bechthold, P.; Jasen, P.; Gonzalez, E.; Juan, A.

    2014-01-01

    The aim of this work is to study the electron transport in graphene with impurities by introducing a generalization of linear response theory for linear dispersion relations and spinor wave functions. Current response and density response functions are derived and computed in the Boltzmann limit showing that in the former case a minimum conductivity appears in the no-disorder limit. In turn, from the generalization of both functions, an exact relation can be obtained that relates both. Combining this result with the relation given by the continuity equation it is possible to obtain general functional behavior of the diffusion pole. Finally, a dynamical diffusion is computed in the quasistatic limit using the definition of relaxation function. A lower cutoff must be introduced to regularize infrared divergences which allow us to obtain a full renormalization group equation for the Fermi velocity, which is solved up to order O(ℏ 2 )

  18. Ac-induced disruption of the doubleDs structure in tomato

    NARCIS (Netherlands)

    Rommens, Caius M.T.; Biezen, Erik A. van der; Ouwerkerk, Pieter B.F.; Nijkamp, H. John J.; Hille, Jacques

    1991-01-01

    The maize doubleDs element is stably maintained in the tomato genome. Upon the subsequent introduction of Ac into a plant containing doubleDs, disruption of the doubleDs structure and DNA rearrangements at the site of the doubleDs element were observed. No indications were obtained for excision of

  19. Field on Poincare group and quantum description of orientable objects

    Energy Technology Data Exchange (ETDEWEB)

    Gitman, D.M. [Universidade de Sao Paulo, Instituto de Fisica, Caixa Postal 66318-CEP, Sao Paulo, S.P. (Brazil); Shelepin, A.L. [Moscow Institute of Radio Engineering, Electronics and Automation, Moscow (Russian Federation)

    2009-05-15

    We propose an approach to the quantum-mechanical description of relativistic orientable objects. It generalizes Wigner's ideas concerning the treatment of nonrelativistic orientable objects (in particular, a nonrelativistic rotator) with the help of two reference frames (space-fixed and body-fixed). A technical realization of this generalization (for instance, in 3+1 dimensions) amounts to introducing wave functions that depend on elements of the Poincare group G. A complete set of transformations that test the symmetries of an orientable object and of the embedding space belongs to the group {pi}=G x G. All such transformations can be studied by considering a generalized regular representation of G in the space of scalar functions on the group, f(x,z), that depend on the Minkowski space points x element of G/Spin(3,1) as well as on the orientation variables given by the elements z of a matrix Z element of Spin(3,1). In particular, the field f(x,z) is a generating function of the usual spin-tensor multi-component fields. In the theory under consideration, there are four different types of spinors, and an orientable object is characterized by ten quantum numbers. We study the corresponding relativistic wave equations and their symmetry properties. (orig.)

  20. Epinephrine inhanced double contrast knee arthrography

    International Nuclear Information System (INIS)

    Lee, Jae Mun; Choi, Byung Ihn

    1981-01-01

    It is well known that double contrast knee arthrography is useful in diagnosis of meniscal lesions and other knee pathology. But intra-articular structures become less well delineated shortly after injection into the knee joint with water soluble contrast media because of rapid absorption and dilution of the injected media. This limits the time when sharply detailed arthrograms are obtainable and precludes repeat delayed arthrogram without reinjection of contrast media. In order to overcome this major disadvantage, the authors used epinephrine which has vasoconstrictive effect and is expected to reduce fluid movement across the synovial membrane temporarily. The authors attempted to compare epinephrine inhanced double contrast arthrographic group, epinephrine(+) group, to the double contrast arthrographic group without epinephrine, epinephrine(-) group, by statistical evaluation. Each group consisted of 35 cases and 7 lateral films of knee joint were taken sequentially 2, 6, 10, 15, 20, 30, and 60 minutes after injection of contrast media, and were assessed by 5 certified radiologists. The results were as follows: 1. The difference of mean score of quality between epinephrine(+) group and epinephrine(-) group was statistically significant at every time interval (ρ value < 0.01 at 2 minutes, ρ < 0.001 at all other time intervals). Epinephrine(+) group was superior to the epinephrine(-) group in quality of film. 2. Numbers of cases above score of 2 which was considered to be of diagnostic quality in evaluating meniscal lesions were larger in epinephrine(+) group than epinephrine(-) group at every time interval. And the difference between two groups was highly significant statistically (ρ < 0.001). 3. Only 43% of cases was above score of 2 at 10 minutes in epinephrine(-) group, but 97% at 10 minutes and 80% at 20 minutes respectively in epinephrine(+) group. Therefore duration for adequate study of arthrogram is prolonged more than two times in epinephrine(+) group

  1. The Double Star mission

    Directory of Open Access Journals (Sweden)

    Liu

    2005-11-01

    Full Text Available The Double Star Programme (DSP was first proposed by China in March, 1997 at the Fragrant Hill Workshop on Space Science, Beijing, organized by the Chinese Academy of Science. It is the first mission in collaboration between China and ESA. The mission is made of two spacecraft to investigate the magnetospheric global processes and their response to the interplanetary disturbances in conjunction with the Cluster mission. The first spacecraft, TC-1 (Tan Ce means "Explorer", was launched on 29 December 2003, and the second one, TC-2, on 25 July 2004 on board two Chinese Long March 2C rockets. TC-1 was injected in an equatorial orbit of 570x79000 km altitude with a 28° inclination and TC-2 in a polar orbit of 560x38000 km altitude. The orbits have been designed to complement the Cluster mission by maximizing the time when both Cluster and Double Star are in the same scientific regions. The two missions allow simultaneous observations of the Earth magnetosphere from six points in space. To facilitate the comparison of data, half of the Double Star payload is made of spare or duplicates of the Cluster instruments; the other half is made of Chinese instruments. The science operations are coordinated by the Chinese DSP Scientific Operations Centre (DSOC in Beijing and the European Payload Operations Service (EPOS at RAL, UK. The spacecraft and ground segment operations are performed by the DSP Operations and Management Centre (DOMC and DSOC in China, using three ground station, in Beijing, Shanghai and Villafranca.

  2. Double your money

    International Nuclear Information System (INIS)

    Moxon, Suzanne

    1998-01-01

    The government-owned Hydro-Quebec was instructed to take certain actions, one of which was to increase profits. The company has published a report describing its plans for 1998-2002. The company expects to increase sales and double its income over the five years. Hydro-Quebec (which produces or purchases 97% of the electricity consumed in the province) will freeze prices until April 2002. Environmental considerations and liaison with local communities are included in the 5-year plan. The company expects to invest c$1.2B in international markets over the five years and C$20M per year are earmarked for research. (UK)

  3. Layered double hydroxides

    DEFF Research Database (Denmark)

    López Rayo, Sandra; Imran, Ahmad; Hansen, Hans Chr. Bruun

    2017-01-01

    A novel zinc (Zn) fertilizer concept based on Zn doped layered double hydroxides (Zn-doped Mg-Fe-LDHs) has been investigated. Zn-doped Mg-Fe-LDHs were synthetized, their chemical composition was analyzed and their nutrient release was studied in buffered solutions with different pH values. Uptake...... equation showing maximum release at pH 5.2, reaching approximately 45% of the total Zn content. The Zn concentrations in the plants receiving the LDHs were between 2- and 9.5-fold higher than those in plants without Zn addition. A positive effect of the LDHs was also found in soil. This work documents...

  4. Double sodium rubidium molybdates

    International Nuclear Information System (INIS)

    Mokhoseev, M.V.; Khal'baeva, K.M.; Khajkina, E.G.; Ogurtsov, A.M.

    1990-01-01

    According to ceramic technique double sodium-rubidium molybdates of the compositions Rb 2-x Na x MoO 4 (0.5≤x≤0.67) and Na 3 Rb(MoO 4 ) 2 have been prepared. It is ascertained that Rb 2-x Na x MoO 4 is crystallized in glaserite structural type (trigonal crystal system, sp.gr. P3m1, Z=2) and melts incongruently at 640 deg C. Na 3 Rb(MoO 4 ) 2 at room temperature is unstable and gradually decomposes into Na 2 MoO 4 and Rb 2-x Na x MoO 4

  5. Double profunda brachii artery

    OpenAIRE

    Gavishiddappa A Hadimani; Jyoti V Hadimani; Ishwar B Bagoji; Shardha Bai Rathod; Balappa M Bannur

    2016-01-01

    Brachial artery (BA) is a continuation of the axillary artery at the lower border of teres major. In the cubital fossa, BA divides into radial artery and ulnar artery as terminal branches. Large branch given from the BA in the upper part is profunda brachii artery. In the present case, we noticed double profunda brachii that arises from the BA. They are profunda brachii artery 1 and profunda brachii artery 2. Profunda brachii artery 1 arises in the proximal part of the BA and profunda brachii...

  6. Firewalls from double purity

    Science.gov (United States)

    Bousso, Raphael

    2013-10-01

    The firewall paradox is often presented as arising from double entanglement, but I argue that more generally the paradox is double purity. Near-horizon modes are purified by the interior, in the infalling vacuum. Hence, they cannot also be pure alone, or in combination with any third system, as demanded by unitarity. This conflict arises independently of the Page time, for entangled and for pure states. It implies that identifications of Hilbert spaces cannot resolve the paradox. Traditional complementarity requires the unitary identification of infalling matter with a scrambled subsystem of the Hawking radiation. Extending this map to the infalling vacuum overdetermines the out-state. More general complementarity maps (“A=RB,” “ER=EPR”) necessarily fail when the near-horizon zone is pure. I argue that pure-zone states span the microcanonical ensemble, and that this suffices to make the horizon a special place. I advocate that the ability to detect the horizon locally, rather than the degree or probability of violence, is what makes firewalls problematic. Conversely, if the production of matter at the horizon can be dynamically understood and shown to be consistent, then firewalls do not constitute a violation of the equivalence principle.

  7. Double Degenerate Stars

    International Nuclear Information System (INIS)

    Xin-Lian, Luo; Hua, Bai; Lei, Zhao

    2008-01-01

    Regardless of the formation mechanism, an exotic object, the double degenerate star (DDS), is introduced and investigated, which is composed of baryonic matter and some unknown fermion dark matter. Different from the simple white dwarfs (WDs), there is additional gravitational force provided by the unknown fermion component inside DDSs, which may strongly affect the structure and the stability of such kind of objects. Many possible and strange observational phenomena connecting with them are concisely discussed. Similar to the normal WD, this object can also experience thermonuclear explosion as type Ia supernova explosion when DDS's mass exceeds the maximum mass that can be supported by electron degeneracy pressure. However, since the total mass of baryonic matter can be much lower than that of WD at Chandrasekhar mass limit, the peak luminosity should be much dimmer than what we expect before, which may throw a slight shadow on the standard candle of SN Ia in the research of cosmology. (general)

  8. Double photoionization of strontium

    Energy Technology Data Exchange (ETDEWEB)

    Sokell, Emma; Grimm, Michael; Sheridan, Paul, E-mail: emma.sokell@ucd.i [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)

    2010-02-01

    Resonant triple-differential cross-section (TDCS) measurements have been used to study the double photoionization process in strontium. Two sets of measurements were made at the photon energy of the 4p {yields} 4d resonance. The coplanar geometry was used and the fixed analyser, positioned at -90{sup 0} to the main axis of polarization of the photons, detected electrons with {approx}65% of the available excess energy. The mutual angle between the two electrons had a range just short of 90 {yields} 270{sup 0}. The TDCS exhibit unexpected lobes at a mutual angle of 180{sup 0}. Comparison with other measurements made with the same geometry but with different sharings of the available energy indicate that these TDCS all show the unexpected lobe. Some possible explanations for the lobe are considered.

  9. Double-Skin Facade

    DEFF Research Database (Denmark)

    Kalyanova, Olena

    favored by companies and their employees. To bring the reduction of energy use in these buildings application of suitable tools and methods is necessary to achieve successful design solutions. Earlier work on the topic of DSF modelling was examined from various publications. As a result, the main...... IEA Annex 34/43, subtask E "Double-Skin Facade". The results of empirical validation are discussed in this work. Discussion and analysis of experimental results is carried out. It has lead to hypothesis of recirculation flow phenomenon in the DSF cavity. Finally, a suggestion of a new numerical model...... is developed to account for recirculation flow appearance in the DSF cavity. The model is based on a simple mass balance between the boundary layer flow and the main flow in the cavity....

  10. Deconvoluting double Doppler spectra

    International Nuclear Information System (INIS)

    Ho, K.F.; Beling, C.D.; Fung, S.; Chan, K.L.; Tang, H.W.

    2001-01-01

    The successful deconvolution of data from double Doppler broadening of annihilation radiation (D-DBAR) spectroscopy is a promising area of endeavour aimed at producing momentum distributions of a quality comparable to those of the angular correlation technique. The deconvolution procedure we test in the present study is the constrained generalized least square method. Trials with computer simulated DDBAR spectra are generated and deconvoluted in order to find the best form of regularizer and the regularization parameter. For these trials the Neumann (reflective) boundary condition is used to give a single matrix operation in Fourier space. Experimental D-DBAR spectra are also subject to the same type of deconvolution after having carried out a background subtraction and using a symmetrize resolution function obtained from an 85 Sr source with wide coincidence windows. (orig.)

  11. Beyond the double banana

    DEFF Research Database (Denmark)

    Rosenzweig, Ivana; Fogarasi, András; Johnsen, Birger

    2014-01-01

    PURPOSE: To investigate whether extending the 10-20 array with 6 electrodes in the inferior temporal chain and constructing computed montages increases the diagnostic value of ictal EEG activity originating in the temporal lobe. In addition, the accuracy of computer-assisted spectral source......). Spectral source analysis used source montage to calculate density spectral array, defining the earliest oscillatory onset. From this, phase maps were calculated for localization. The reference standard was the decision of the multidisciplinary epilepsy surgery team on the seizure onset zone. Clinical...... performance was compared with the double banana (longitudinal bipolar montage, 10-20 array). RESULTS: Adding the inferior temporal electrode chain, computed montages (reference free, common average, and source derivation), and voltage maps significantly increased the sensitivity. Phase maps had the highest...

  12. Double-mode pulsation

    International Nuclear Information System (INIS)

    Cox, A.N.

    1982-01-01

    Double mode pulsation is a very pervasive phenomenon in stars all over the Hertzsprung-Russell diagram. In order of increasing radius, examples are: ZZ Ceti stars, the sun, the delta Scuti stars, RR Lyrae variables, the β Cephei variables and those related to them, Cepheids, and maybe even the Mira stars. These many modes have been interpreted as both radial and nonradial modes, but in many cases the actual mode has not been clearly identified. Yellow giants seem to be the most simple pulsators with a large majority of the RR Lyrae variables and Cepheids showing only one pulsation period. We limit this review to those very few cases for classical Cepheids and RR Lyrae variables which display two modes. For these we know many facts about these stars, but the actual cause of the pulsation in two modes simultaneously remains unknown

  13. Dual double field theory

    Energy Technology Data Exchange (ETDEWEB)

    Bergshoeff, Eric A. [Centre for Theoretical Physics, University of Groningen,Nijenborgh 4, 9747 AG Groningen (Netherlands); Hohm, Olaf [Simons Center for Geometry and Physics, Stony Brook University,Stony Brook, NY 11794-3636 (United States); Penas, Victor A. [Centre for Theoretical Physics, University of Groningen,Nijenborgh 4, 9747 AG Groningen (Netherlands); Riccioni, Fabio [INFN - Sezione di Roma, Dipartimento di Fisica, Università di Roma “La Sapienza”,Piazzale Aldo Moro 2, 00185 Roma (Italy)

    2016-06-06

    We present the dual formulation of double field theory at the linearized level. This is a classically equivalent theory describing the duals of the dilaton, the Kalb-Ramond field and the graviton in a T-duality or O(D,D) covariant way. In agreement with previous proposals, the resulting theory encodes fields in mixed Young-tableau representations, combining them into an antisymmetric 4-tensor under O(D,D). In contrast to previous proposals, the theory also requires an antisymmetric 2-tensor and a singlet, which are not all pure gauge. The need for these additional fields is analogous to a similar phenomenon for “exotic' dualizations, and we clarify this by comparing with the dualizations of the component fields. We close with some speculative remarks on the significance of these observations for the full non-linear theory yet to be constructed.

  14. Double profunda brachii artery

    Directory of Open Access Journals (Sweden)

    Gavishiddappa A Hadimani

    2016-01-01

    Full Text Available Brachial artery (BA is a continuation of the axillary artery at the lower border of teres major. In the cubital fossa, BA divides into radial artery and ulnar artery as terminal branches. Large branch given from the BA in the upper part is profunda brachii artery. In the present case, we noticed double profunda brachii that arises from the BA. They are profunda brachii artery 1 and profunda brachii artery 2. Profunda brachii artery 1 arises in the proximal part of the BA and profunda brachii artery 2 arises distal to the profunda brachii artery 1. Both the arteries run inferolaterally in the spiral groove along with radial nerve. Variations of profunda brachii artery are important during harvesting of the lateral arm flaps and may lead to inadvertent injury during percutaneous arterial catheterization or injection of drugs.

  15. GENERALIZED DOUBLE PARETO SHRINKAGE.

    Science.gov (United States)

    Armagan, Artin; Dunson, David B; Lee, Jaeyong

    2013-01-01

    We propose a generalized double Pareto prior for Bayesian shrinkage estimation and inferences in linear models. The prior can be obtained via a scale mixture of Laplace or normal distributions, forming a bridge between the Laplace and Normal-Jeffreys' priors. While it has a spike at zero like the Laplace density, it also has a Student's t -like tail behavior. Bayesian computation is straightforward via a simple Gibbs sampling algorithm. We investigate the properties of the maximum a posteriori estimator, as sparse estimation plays an important role in many problems, reveal connections with some well-established regularization procedures, and show some asymptotic results. The performance of the prior is tested through simulations and an application.

  16. Group X

    Energy Technology Data Exchange (ETDEWEB)

    Fields, Susannah

    2007-08-16

    This project is currently under contract for research through the Department of Homeland Security until 2011. The group I was responsible for studying has to remain confidential so as not to affect the current project. All dates, reference links and authors, and other distinguishing characteristics of the original group have been removed from this report. All references to the name of this group or the individual splinter groups has been changed to 'Group X'. I have been collecting texts from a variety of sources intended for the use of recruiting and radicalizing members for Group X splinter groups for the purpose of researching the motivation and intent of leaders of those groups and their influence over the likelihood of group radicalization. This work included visiting many Group X websites to find information on splinter group leaders and finding their statements to new and old members. This proved difficult because the splinter groups of Group X are united in beliefs, but differ in public opinion. They are eager to tear each other down, prove their superiority, and yet remain anonymous. After a few weeks of intense searching, a list of eight recruiting texts and eight radicalizing texts from a variety of Group X leaders were compiled.

  17. Double optical gating

    Science.gov (United States)

    Gilbertson, Steve

    The observation and control of dynamics in atomic and molecular targets requires the use of laser pulses with duration less than the characteristic timescale of the process which is to be manipulated. For electron dynamics, this time scale is on the order of attoseconds where 1 attosecond = 10 -18 seconds. In order to generate pulses on this time scale, different gating methods have been proposed. The idea is to extract or "gate" a single pulse from an attosecond pulse train and switch off all the other pulses. While previous methods have had some success, they are very difficult to implement and so far very few labs have access to these unique light sources. The purpose of this work is to introduce a new method, called double optical gating (DOG), and to demonstrate its effectiveness at generating high contrast single isolated attosecond pulses from multi-cycle lasers. First, the method is described in detail and is investigated in the spectral domain. The resulting attosecond pulses produced are then temporally characterized through attosecond streaking. A second method of gating, called generalized double optical gating (GDOG), is also introduced. This method allows attosecond pulse generation directly from a carrier-envelope phase un-stabilized laser system for the first time. Next the methods of DOG and GDOG are implemented in attosecond applications like high flux pulses and extreme broadband spectrum generation. Finally, the attosecond pulses themselves are used in experiments. First, an attosecond/femtosecond cross correlation is used for characterization of spatial and temporal properties of femtosecond pulses. Then, an attosecond pump, femtosecond probe experiment is conducted to observe and control electron dynamics in helium for the first time.

  18. Group Flow and Group Genius

    Science.gov (United States)

    Sawyer, Keith

    2015-01-01

    Keith Sawyer views the spontaneous collaboration of group creativity and improvisation actions as "group flow," which organizations can use to function at optimum levels. Sawyer establishes ideal conditions for group flow: group goals, close listening, complete concentration, being in control, blending egos, equal participation, knowing…

  19. Student Observations of Double Star Delta Orionis (STFA 14 AC)

    Science.gov (United States)

    Estrada, Reed; Aguilera, Sophia; Bowden, Sam; Gillette, Travis; Givens, Jalynn; Reder, Gabriel; Rhoades, Breauna; Sharpe, Scott; Shattles, Jenna; Cha, Brendon; Do, Vicky; Ewing, Malachi; Kiamco, Alex Junior; Nelms, Brenda; Peña, Emilie; Maricarmen, Richard; Thielen, Austin

    2018-01-01

    A group of eight eighth graders and eight high schoolers studied the double star STFA 14 AC. They used the procedure from Argyle's book to get the separation and position angle for the double star. The students used a Celestron C8 Schmidt-Cassegrain telescope with a Baader Planetarium microguide eyepiece with similar markings to a Celestron Eyepiece. The students determined the separation to be 56 arcseconds and the position angle to be 4.19°. They compared their results to the Washington Double Star Catalog and found that they had a 2.88 arcseconds difference in separation and a 2.19° in position angle.

  20. Permutation groups

    CERN Document Server

    Passman, Donald S

    2012-01-01

    This volume by a prominent authority on permutation groups consists of lecture notes that provide a self-contained account of distinct classification theorems. A ready source of frequently quoted but usually inaccessible theorems, it is ideally suited for professional group theorists as well as students with a solid background in modern algebra.The three-part treatment begins with an introductory chapter and advances to an economical development of the tools of basic group theory, including group extensions, transfer theorems, and group representations and characters. The final chapter feature

  1. Deformed quantum double realization of the toric code and beyond

    Science.gov (United States)

    Padmanabhan, Pramod; Ibieta-Jimenez, Juan Pablo; Bernabe Ferreira, Miguel Jorge; Teotonio-Sobrinho, Paulo

    2016-09-01

    Quantum double models, such as the toric code, can be constructed from transfer matrices of lattice gauge theories with discrete gauge groups and parametrized by the center of the gauge group algebra and its dual. For general choices of these parameters the transfer matrix contains operators acting on links which can also be thought of as perturbations to the quantum double model driving it out of its topological phase and destroying the exact solvability of the quantum double model. We modify these transfer matrices with perturbations and extract exactly solvable models which remain in a quantum phase, thus nullifying the effect of the perturbation. The algebra of the modified vertex and plaquette operators now obey a deformed version of the quantum double algebra. The Abelian cases are shown to be in the quantum double phase whereas the non-Abelian phases are shown to be in a modified phase of the corresponding quantum double phase. These are illustrated with the groups Zn and S3. The quantum phases are determined by studying the excitations of these systems namely their fusion rules and the statistics. We then go further to construct a transfer matrix which contains the other Z2 phase namely the double semion phase. More generally for other discrete groups these transfer matrices contain the twisted quantum double models. These transfer matrices can be thought of as being obtained by introducing extra parameters into the transfer matrix of lattice gauge theories. These parameters are central elements belonging to the tensor products of the algebra and its dual and are associated to vertices and volumes of the three dimensional lattice. As in the case of the lattice gauge theories we construct the operators creating the excitations in this case and study their braiding and fusion properties.

  2. The R-operator for a modular double

    International Nuclear Information System (INIS)

    Chicherin, D; Derkachov, S

    2014-01-01

    We construct the R-operator—the solution of the Yang–Baxter equation acting in the tensor product π s 1 ⊗π s 2 of two infinite-dimensional representations of Faddeev’s modular double. This R-operator intertwines the product of two L-operators associated with the modular double and it is built from three basic operators generating the permutation group of four parameters S 4 . (paper)

  3. Etiological aspects of double monsters.

    Science.gov (United States)

    Jaschevatzky, O E; Goldman, B; Kampf, D; Wexler, H; Grünstein, S

    1980-06-01

    Four cases of double monsters are reported, including a rare case of craniofacial duplication (diprosopus). Based on the findings observed, etiological factors of these malformations are discussed. We suggest that exogenous (environmental) factors such as habits, way of life or religious practices of certain populations can influence the development of double monsters.

  4. Double-blind, randomized phase 3 trial of low-dose 13-cis retinoic acid in the prevention of second primaries in head and neck cancer: Long-term follow-up of a trial of the Eastern Cooperative Oncology Group-ACRIN Cancer Research Group (C0590).

    Science.gov (United States)

    Bhatia, Aarti K; Lee, Ju-Whei; Pinto, Harlan A; Jacobs, Charlotte D; Limburg, Paul J; Rubin, Philip; Arusell, Robert M; Dunphy, Eamonn P; Khandekar, Janardan D; Reiner, Seth A; Baez-Diaz, Luis; Celano, Paul; Li, Shuli; Li, Yi; Burtness, Barbara A; Adams, George L; Pandya, Kishan J

    2017-12-01

    13-Cis retinoic acid (13-CRA) is a synthetic vitamin A derivative. High-dose 13-CRA in patients with squamous cell cancers of the head and neck (SCCHNs) reduces the incidence of second primary tumors (SPTs). The authors report long-term results from a phase 3 randomized trial that compared treatment with low-dose 13-CRA versus placebo for patients who had early stage SCCHN, with a focus on the development of SPTs and overall survival (OS). In total, 176 patients who received treatment for stage I/II SCCHN were randomized to receive either low-dose 13-CRA (weight-based dose of 7.5 mg or 10 mg) or placebo for 2 years. A competing-risk approach and the log-rank test were used to compare the time to SPT and OS, respectively, between groups. 13-CRA neither significantly reduced the cumulative incidence of SPT (P = .61) nor improved the time to SPT (hazard ratio [HR] for 13-CRA/placebo; 0.86; P = .61). Despite limited power, there was a trend toward improved OS for the 13-CRA arm (HR, 0.75; P = .14), particularly among patients whose index tumor was surgically excised (N = 26; HR, 0.50; P = .057) and among women (N = 39; HR, 0.44; P = .065) and never/former smokers (N = 129; HR, 0.61; P = .055), with a median follow-up of 16 years. The main 13-CRA related toxicities were dry skin and cheilitis. Treatment with low-dose 13-CRA for 2 years did not decrease the incidence of SPT; subset analysis indicates a potential survival advantage among patients who are women and never/former smokers. More targeted interventions based on clinical risk factors and molecular characterization of tumors may yield greater success in future prevention trials. Cancer 2017;123:4653-4662. © 2017 American Cancer Society. © 2017 American Cancer Society.

  5. A randomized, double-masked, parallel-group, comparative study to evaluate the clinical efficacy and safety of 1% azithromycin–0.1% dexamethasone combination compared to 1% azithromycin alone, dexamethasone 0.1% alone, and vehicle in the treatment of subjects with blepharitis

    Directory of Open Access Journals (Sweden)

    Hosseini K

    2016-08-01

    Full Text Available Kamran Hosseini,1 Richard L Lindstrom,2,3 Gary Foulks,4 Kelly K Nichols5 1InSite Vision, Alameda, CA, 2Minnesota Eye Consultants, 3Department of Ophthalmology and Visual Neurosciences, University of Minnesota Medical School, Minneapolis, MN, 4Department of Ophthalmology and Vision Science, School of Medicine, University of Louisville, Louisville, KY, 5School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA Purpose: To evaluate the clinical efficacy and safety of a 1% azithromycin–0.1% dexamethasone combination in DuraSite (“combination” compared to 0.1% dexamethasone in DuraSite, 1% azithromycin in DuraSite, and vehicle in the treatment of subjects with blepharitis.Materials and methods: This was a Phase III, double-masked, vehicle-controlled, four-arm study in which 907 subjects with blepharitis were randomized to combination (n=305, 0.1% dexamethasone (n=298, 1% azithromycin (n=155, or vehicle (n=149. Ten study visits were scheduled: screening visit, days 1 and 4 (dosing phase and 15, and months 1–6 (follow-up phase. On day 1, subjects applied one drop of the study drug to the eyelid of the inflamed eye(s twice daily, and continued with twice-daily dosing for 14 days. After completing 14 days of dosing, subjects were followed for 6 months for efficacy and safety.Results: A total of 57 subjects (6.3% had complete clinical resolution at day 15: 25 (8.2%, 17 (5.7%, 8 (5.2%, and 7 (4.7% subjects in the combination-, 0.1% dexamethasone-, 1% azithromycin-, and vehicle-treatment groups, respectively. The combination was superior to 1% azithromycin and vehicle alone, but not to 0.1% dexamethasone alone. Mean composite (total clinical sign and symptom scores improved in all four treatment groups during the posttreatment evaluation phase for the intent-to-treat population, but outcomes were superior when a drop containing 0.1% dexamethasone was utilized. Clinical response was noted as early as day 4, and persisted as long

  6. Double Charge Exchange Reactions and Double Beta Decay

    Science.gov (United States)

    Auerbach, N.

    2018-05-01

    The subject of this presentation is at the forefront of nuclear physics, namely double beta decay. In particular one is most interested in the neutrinoless process of double beta decay, when the decay proceeds without the emission of two neutrinos. The observation of such decay would mean that the lepton conservation symmetry is violated and that the neutrinos are of Majorana type, meaning that they are their own anti-particles. The life time of this process has two unknowns, the mass of the neutrino and the nuclear matrix element. Determining the nuclear matrix element and knowing the cross-section well will set limits on the neutrino mass. There is a concentrated effort among the nuclear physics community to calculate this matrix element. Usually these matrix elements are a very small part of the total strength of the transition operators involved in the process. There is no simple way to “calibrate” the nuclear double beta decay matrix element. The double beta decay is a double charge exchange process, therefore it is proposed that double charge exchange reactions using ion projectiles on nuclei that are candidates for double beta decay, will provide additional necessary information about the nuclear matrix elements.

  7. The double Chooz hardware trigger system

    Energy Technology Data Exchange (ETDEWEB)

    Cucoanes, Andi; Beissel, Franz; Reinhold, Bernd; Roth, Stefan; Stahl, Achim; Wiebusch, Christopher [RWTH Aachen (Germany)

    2008-07-01

    The double Chooz neutrino experiment aims to improve the present knowledge on {theta}{sub 13} mixing angle using two similar detectors placed at {proportional_to}280 m and respectively 1 km from the Chooz power plant reactor cores. The detectors measure the disappearance of reactor antineutrinos. The hardware trigger has to be very efficient for antineutrinos as well as for various types of background events. The triggering condition is based on discriminated PMT sum signals and the multiplicity of groups of PMTs. The talk gives an outlook to the double Chooz experiment and explains the requirements of the trigger system. The resulting concept and its performance is shown as well as first results from a prototype system.

  8. Group devaluation and group identification

    NARCIS (Netherlands)

    Leach, C.W.; Rodriguez Mosquera, P.M.; Vliek, M.L.W.; Hirt, E.

    2010-01-01

    In three studies, we showed that increased in-group identification after (perceived or actual) group devaluation is an assertion of a (preexisting) positive social identity that counters the negative social identity implied in societal devaluation. Two studies with real-world groups used order

  9. Lie groups and algebraic groups

    Indian Academy of Sciences (India)

    We give an exposition of certain topics in Lie groups and algebraic groups. This is not a complete ... of a polynomial equation is equivalent to the solva- bility of the equation ..... to a subgroup of the group of roots of unity in k (in particular, it is a ...

  10. Double chambered right ventricle

    International Nuclear Information System (INIS)

    Cho, Chul Koo; Yu, Yun Jeong; Yeon, Kyung Mo; Han, Man Chung

    1983-01-01

    Fourteen cases of double chambered right ventricle were diagnosed angiographically and of these nine cases were confirmed after operation and autopsy at Seoul National University Hospital in recent four years since 1979. The clinical and radiological findings with the emphasis on the cinecardiographic findings were analysed. The summaries of the analysis are as follows: 1. Among 14 cases, 6 cases were male and 8 cases were female. Age distribution was from 4 years to 36 years. 2. In chest x-ray findings, pulmonary vascularity was increased in 8 cases, decreased in 4 cases, and normal in 2 cases. Cardiomegaly was observed in 8 cases and other showed normal heart size. 3. In cinecardiography, 11 cases had interventricular septal defect. Among these 11 cases, VSD located in proximal high pressure chamber was in 2 cases and located in distal low pressure chamber was in 9 cases. 4. The location of aberrant muscle bundle in sinus portion of right ventricle was in 8 cases. In the rest 6 cases, the aberrant muscle bundle was located below the infundibulum of right ventricle. 5. For accurate diagnosis and differential diagnosis with other congenital cardiac anomalies such as Tetralogy of Fallot or isolated pulmonic stenosis, biplane cineangiography and catheterization is an essential procedure

  11. Double chambered right ventricle

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Chul Koo; Yu, Yun Jeong; Yeon, Kyung Mo; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1983-12-15

    Fourteen cases of double chambered right ventricle were diagnosed angiographically and of these nine cases were confirmed after operation and autopsy at Seoul National University Hospital in recent four years since 1979. The clinical and radiological findings with the emphasis on the cinecardiographic findings were analysed. The summaries of the analysis are as follows: 1. Among 14 cases, 6 cases were male and 8 cases were female. Age distribution was from 4 years to 36 years. 2. In chest x-ray findings, pulmonary vascularity was increased in 8 cases, decreased in 4 cases, and normal in 2 cases. Cardiomegaly was observed in 8 cases and other showed normal heart size. 3. In cinecardiography, 11 cases had interventricular septal defect. Among these 11 cases, VSD located in proximal high pressure chamber was in 2 cases and located in distal low pressure chamber was in 9 cases. 4. The location of aberrant muscle bundle in sinus portion of right ventricle was in 8 cases. In the rest 6 cases, the aberrant muscle bundle was located below the infundibulum of right ventricle. 5. For accurate diagnosis and differential diagnosis with other congenital cardiac anomalies such as Tetralogy of Fallot or isolated pulmonic stenosis, biplane cineangiography and catheterization is an essential procedure.

  12. Double Tracks closure report

    International Nuclear Information System (INIS)

    1997-06-01

    This report describes the remediation activities performed and the results of postremediation radiation surveys conducted at the Double Tracks site, located on Range 71 North, of the Nellis Air Force Range (NAFR) in southern Nevada. This remediation was conducted from June to August 1996 in accordance with the Interim Corrective Action Plan (ICAP) to remediate the site to an acceptable risk to human health and the environment. Soil with a total transuranic activity greater than 200 picoCuries per gram (pCi/g) was excavated, shipped to the Nevada Test Site (NTS), and disposed at the Area 3 Radioactive Waste Management Site (RWMS). A total of 52.3 grams of plutonium (Pu) with an activity of 5.12 Curies was disposed. The concrete pad at ground zero (GZ) was broken up, placed in a Sealand reg-sign container, and shipped to the NTS Area 6 decontamination pad. Additionally, approximately 10 m 3 (350 ft 3 ) of soil containing small chips of concrete was shipped to the NTS Area 6 decontamination pad. The concrete and soil/concrete mixture will be further characterized prior to disposal. At the time this report was written, characterization samples were being collected, with analytical results expected in January 1997. It is anticipated that the material will be disposed in mid-1997. This remediation is an interim action because final cleanup levels have not been established

  13. Double Beta Decay

    International Nuclear Information System (INIS)

    Fiorini, Ettore

    2008-01-01

    The importance of neutrinoless Double Beta Decay (DBD) is stressed in view of the recent results of experiments on neutrino oscillations which indicate that the difference between the squared masses of two neutrinos of different flavours is finite [For a recent review including neutrino properties and recent results see: Review of Particle Physics, J. of Phys. G: Nuclear and Particle Physics 33, 1]. As a consequence the mass of at least one neutrino has to be different from zero and it becomes imperative to determine its absolute value. The various experimental techniques to search for DBD are discussed together with the difficult problems of the evaluation of the corresponding nuclear matrix elements. The upper limits on neutrino mass coming from the results of the various experiments are reported together with the indication for a non zero value by one of them not confirmed so far. The two presently running experiments on neutrinoless DBD are briefly described together with the already approved or designed second generation searches aiming to reach the values on the absolute neutrino mass indicated by the results on neutrino oscillations

  14. Group Work

    Science.gov (United States)

    Wilson, Kristy J.; Brickman, Peggy; Brame, Cynthia J.

    2018-01-01

    Science, technology, engineering, and mathematics faculty are increasingly incorporating both formal and informal group work in their courses. Implementing group work can be improved by an understanding of the extensive body of educational research studies on this topic. This essay describes an online, evidence-based teaching guide published by…

  15. Reflection groups

    International Nuclear Information System (INIS)

    Eggermont, G.

    2006-01-01

    In 2005, PISA organised proactive meetings of reflection groups on involvement in decision making, expert culture and ethical aspects of radiation protection.All reflection group meetings address particular targeted audiences while the output publication in book form is put forward

  16. Z₂-double cyclic codes

    OpenAIRE

    Borges, J.

    2014-01-01

    A binary linear code C is a Z2-double cyclic code if the set of coordinates can be partitioned into two subsets such that any cyclic shift of the coordinates of both subsets leaves invariant the code. These codes can be identified as submodules of the Z2[x]-module Z2[x]/(x^r − 1) × Z2[x]/(x^s − 1). We determine the structure of Z2-double cyclic codes giving the generator polynomials of these codes. The related polynomial representation of Z2-double cyclic codes and its duals, and the relation...

  17. Aspects of the doubled worldsheet

    Energy Technology Data Exchange (ETDEWEB)

    Driezen, Sibylle; Sevrin, Alexander; Thompson, Daniel C. [Theoretische Natuurkunde, Vrije Universiteit Brussel and The International Solvay Institutes,Pleinlaan 2, B-1050 Brussels (Belgium)

    2016-12-16

    We clarify the relation between various approaches to the manifestly T-duality symmetric string. We explain in detail how the PST covariant doubled string arises from an unusual gauge fixing. We pay careful attention to the role of “spectator” fields in this process and also show how the T-duality invariant doubled dilaton emerges naturally. We extend these ideas to non-Abelian T-duality and show they give rise to the duality invariant formalism based on the semi-Abelian Drinfeld Double. We then develop the N=(0,1) supersymmetric duality invariant formalism.

  18. Gastroesophageal anastomosis: single-layer versus double-layer technique

    International Nuclear Information System (INIS)

    Aslam, V.A.; Bilal, A.; Khan, A.; Ahmed, M.

    2008-01-01

    Considerable controversy exists regarding the optimum technique for gastroesophageal anastomosis. Double layer technique has long been considered important for safe healing but there is evidence that single layer technique is also safe and can be performed in much shorter time. The purpose of this study was to compare the outcome of single layer and double layer techniques for gastroesophageal anastomosis. A prospective randomized study was conducted in cardiothoracic unit, Lady Reading Hospital from Jan 2006 to Jan 2008. Fifty patients with oesophageal carcinoma undergoing subtotal oesophagectomy were randomized to have the anastomosis by single layer continuous or double layer continuous technique (group A (n=24) and B (n=26) respectively). The demographic data, operative and anastomosis time, postoperative complications and hospital mortality were recorded on a proforma and analyzed on SPSS 10. There was no significant difference between group A and B in terms of age, gender, postoperative complications and duration of hospital stay. Anastomotic leak occurred in 4.2% patients in group A and 7.7% in group B (p=NS). Mean anastomosis time was 10.04 minutes in group A and 19.2 minutes in group B (p=0.0001). Mean operative time was 163.83 minutes and 170.96 minutes in group A and B respectively. Overall hospital mortality was 2%; no deaths occurred due to anastomotic leak. Single layer continuous technique is equally safe and can be performed in shorter time and at a lower cost than the double layer technique. (author)

  19. Original article Role of Tamsulosin in Improving Double-J Ureteric ...

    African Journals Online (AJOL)

    2011-10-04

    related symptoms and quality of life (QoL) in patients with double-J (DJ) ureteric stents. Subjects and Methods: A total of 136 patients were prospectively evaluated and distributed randomly in two groups. Group 1 was 69 ...

  20. Radiologic findings of double contrast knee arthrography

    International Nuclear Information System (INIS)

    Choi, Hye Ran; Ahn, Byeong Yeob; Kim, Mi Young; Lee, So Hyun; Suh, Chang Hae; Chung, Won Kyun

    1990-01-01

    The double contrast arthrography of the knee is a highly accurate diagnostic modality in wide rage of the clinical disorders of the knee. It allows radiological assessment of the menisci, the articular cartilages, the synovium and the ligaments. The double contrast knee arthrography was performed in 356 cases at Inha hospital for about 3 years from June 1986 to June 1989. Among them, 115 cases were abnormal, and were analyzed clinically and radiologically with the back ground of the operative finding. The results were as follows ; 1. Of the 115 cases, male were 77 and female 38. Male exceeds female in the ratio of 2 : 1. 2. The age group of 20 - 39 years was commonly involved (60%). 3. The right knee was more commonly involved than the left and the medial meniscus tear was more common (61%). The posterior horn of the meniscus was more frequently torn than the other parts of the meniscus (42%). 4. The incidence of the bucket-handle tear was the most frequent (33%). 5. The cases of the popliteal cyst were 16 (13.9%), and the combined meniscus tears were in 4 cases (25%). 6. The numbers of the discoid meniscus were 9 (7.8%), and all were present in the lateral meniscus, and combined tears were in 4 cases (44.4%). 7. The diagnostic accuracy of the double contrast knee arthrogram was 82.7% compared with operative finding. The false positive examination were 17.3%

  1. Group theory

    CERN Document Server

    Scott, W R

    2010-01-01

    Here is a clear, well-organized coverage of the most standard theorems, including isomorphism theorems, transformations and subgroups, direct sums, abelian groups, and more. This undergraduate-level text features more than 500 exercises.

  2. Group Grammar

    Science.gov (United States)

    Adams, Karen

    2015-01-01

    In this article Karen Adams demonstrates how to incorporate group grammar techniques into a classroom activity. In the activity, students practice using the target grammar to do something they naturally enjoy: learning about each other.

  3. Computer group

    International Nuclear Information System (INIS)

    Bauer, H.; Black, I.; Heusler, A.; Hoeptner, G.; Krafft, F.; Lang, R.; Moellenkamp, R.; Mueller, W.; Mueller, W.F.; Schati, C.; Schmidt, A.; Schwind, D.; Weber, G.

    1983-01-01

    The computer groups has been reorganized to take charge for the general purpose computers DEC10 and VAX and the computer network (Dataswitch, DECnet, IBM - connections to GSI and IPP, preparation for Datex-P). (orig.)

  4. Group learning

    DEFF Research Database (Denmark)

    Pimentel, Ricardo; Noguira, Eloy Eros da Silva; Elkjær, Bente

    The article presents a study that aims at the apprehension of the group learning in a top management team composed by teachers in a Brazilian Waldorf school whose management is collective. After deciding to extend the school, they had problems recruiting teachers who were already trained based...... on the Steiner´s ideas, which created practical problems for conducting management activities. The research seeks to understand how that group of teachers collectively manage the school, facing the lack of resources, a significant heterogeneity in the relationships, and the conflicts and contradictions......, and they are interrelated to the group learning as the construction, maintenance and reconstruction of the intelligibility of practices. From this perspective, it can be said that learning is a practice and not an exceptional phenomenon. Building, maintaining and rebuilding the intelligibility is the group learning...

  5. Group technology

    International Nuclear Information System (INIS)

    Rome, C.P.

    1976-01-01

    Group Technology has been conceptually applied to the manufacture of batch-lots of 554 machined electromechanical parts which now require 79 different types of metal-removal tools. The products have been grouped into 7 distinct families which require from 8 to 22 machines in each machine-cell. Throughput time can be significantly reduced and savings can be realized from tooling, direct-labor, and indirect-labor costs

  6. Abelian groups

    CERN Document Server

    Fuchs, László

    2015-01-01

    Written by one of the subject’s foremost experts, this book focuses on the central developments and modern methods of the advanced theory of abelian groups, while remaining accessible, as an introduction and reference, to the non-specialist. It provides a coherent source for results scattered throughout the research literature with lots of new proofs. The presentation highlights major trends that have radically changed the modern character of the subject, in particular, the use of homological methods in the structure theory of various classes of abelian groups, and the use of advanced set-theoretical methods in the study of undecidability problems. The treatment of the latter trend includes Shelah’s seminal work on the undecidability in ZFC of Whitehead’s Problem; while the treatment of the former trend includes an extensive (but non-exhaustive) study of p-groups, torsion-free groups, mixed groups, and important classes of groups arising from ring theory. To prepare the reader to tackle these topics, th...

  7. Alignment in double capture processes

    International Nuclear Information System (INIS)

    Moretto-Capelle, P.; Benhenni, M.; Bordenave-Montesquieu, A.; Benoit-Cattin, P.; Gleizes, A.

    1993-01-01

    The electron spectra emitted when a double capture occurs in N 7+ +He and Ne 8+ +He systems at 10 qkeV collisional energy, allow us to determine the angular distributions of the 3 ell 3 ell ' lines through a special spectra fitting procedure which includes interferences between neighbouring states. It is found that the doubly excited states populated in double capture processes are generally aligned

  8. Alignment in double capture processes

    Energy Technology Data Exchange (ETDEWEB)

    Moretto-Capelle, P.; Benhenni, M.; Bordenave-Montesquieu, A.; Benoit-Cattin, P.; Gleizes, A. (IRSAMC, URA CNRS 770, Univ. Paul Sabatier, 118 rte de Narbonne, 31062 Toulouse Cedex (France))

    1993-06-05

    The electron spectra emitted when a double capture occurs in N[sup 7+]+He and Ne[sup 8+]+He systems at 10 qkeV collisional energy, allow us to determine the angular distributions of the 3[ell]3[ell] [prime] lines through a special spectra fitting procedure which includes interferences between neighbouring states. It is found that the doubly excited states populated in double capture processes are generally aligned.

  9. Methods of Mitigating Double Taxation

    OpenAIRE

    Lindhe, Tobias

    2002-01-01

    This paper presents a comprehensive overview of existing methods of mitigating double taxation of corporate income within a standard cost of capital model. Two of the most well-known and most utilized methods, the imputation and the split rate systems, do not mitigate double taxation in corporations where the marginal investment is financed with retained earnings. However, all methods are effective when the marginal investment is financed with new share issues. The corporate tax rate, fiscal ...

  10. Decades with four double triodes

    International Nuclear Information System (INIS)

    Wahl, R.

    1952-01-01

    Decades with four double triodes The described decade consists of four double triodes and four crystals germanium; which has the following characteristics: - Attack in negative impulses. - Sensitivity 12 volts ± 40 % for signals of 1 μs about. - Time of resolution 2,5 μs. - Voltage 250 v ± 40 %. - heating 6,3 v ± 40 %. - Tolerance on the values of the elements of installation 10%. (author) [fr

  11. Double layers above the aurora

    International Nuclear Information System (INIS)

    Temerin, M.; Mozer, F.S.

    1987-01-01

    Two different kinds of double layers were found in association with auroral precipitation. One of these is the so-called electrostatic shock, which is oriented at an oblique angle to the magnetic field in such a way that the perpendicular electric field is much larger than the parallel electric field. This type of double layer is often found at the edges of regions of upflowing ion beams and the direction of the electric fields in the shock points toward the ion beam. The potential drop through the shock can be several kV and is comparable to the total potential needed to produce auroral acceleration. Instabilities associated with the shock may generate obliquely propagating Alfven waves, which may accelerate electrons to produce flickering auroras. The flickering aurora provides evidence that the electrostatic shock may have large temporal fluctuations. The other kind of double layer is the small-amplitude double layer found in regions of upward flowing in beams, often in association with electrostatic ion cyclotron waves. The parallel and perpendicular electric fields in these structures are comparable in magnitude. The associated potentials are a few eV. Since many such double layers are found in regions of upward flowing ion beams, the combined potential drop through a set of these double layers can be substantial

  12. Global effects of double layers

    International Nuclear Information System (INIS)

    Raad, M.A.

    1984-12-01

    Locally the formation of an electrostatic double layer in a current carrying plasma leads to a direct acceleration of particles which may penetrate far into the surrounding medium. The potential across the double layer, giving this acceleration, must be maintained by the external system and is a basic parameter for the local to global coupling. The double layer potential is associated with an electric field parallel to the magnetic field. In general this leads to a magnetohydrodynamic relaxation of the surrounding medium providing the influx of energy which is dissipated by the double layer. The double layer potential is limited as is the maximum possible rate of energy influx. If the global response of the external medium can be represented by an external circuit and if an equivalent circuit element can be found to represent the double layer, for example a negative resistance for intermediate time scales, it is possible to give a description of the dynamics and stability of the whole system. (Author)

  13. Vitrectomy in double-perforation gunshot injury

    Directory of Open Access Journals (Sweden)

    Abd El Alim Mohamed A

    2013-11-01

    Full Text Available Ahmed Abd El Alim MohamedOphthalmology department, Ain Shams University, Cairo, EgyptObjective: This study sought to evaluate the result of pars plana vitrectomy in patients with gunshot wounds involving double perforation.Methods: This was a retrospective, noncomparative, interventional case series.Results: Eighteen patients (18 eyes with double-perforation gunshot injuries were treated from February 2010 to March 2012. The group included 16 men (88% and two women (11%; the mean age was 24 (15–33 years. In each case, vitrectomy was scheduled 1–6 weeks after repair of the entrance site. Associated retinal detachments were observed in two eyes (11%, retinal incarceration was observed surrounding the exit site in three eyes (16%, and retention of an intraocular foreign body was observed in two cases. After a follow-up period of 8 ± 2 months, two eyes (11% had achieved visual acuity (VA of 0.5, nine eyes (50% had achieved VA between 0.5 and 0.1, and seven eyes (38% had achieved VA between 0.1 and hand movement. The main reasons for functional failure (VA 0.1 to hand movement were macular dragging (due to fibrosis at the exit site near the macula in seven cases (38%, submacular hemorrhage in four cases (22%, and epimacular fibrosis in five cases (27%. All cases developed postoperative exotropia. One case (5% developed postoperative hemorrhage. No cases exhibited signs of postoperative redetachment.Conclusion: The outcome of pars plana vitrectomy in cases with double perforations is variable. Factors including the surgeon's skill level, the time to surgery, and the efficacy of the intraocular tamponade affect the postoperative outcome.Keywords: pars plana vitrectomy, gunshot injury, double perforation

  14. Workplace harassment: double jeopardy for minority women.

    Science.gov (United States)

    Berdahl, Jennifer L; Moore, Celia

    2006-03-01

    To date there have been no studies of how both sex and ethnicity might affect the incidence of both sexual and ethnic harassment at work. This article represents an effort to fill this gap. Data from employees at 5 organizations were used to test whether minority women are subject to double jeopardy at work, experiencing the most harassment because they are both women and members of a minority group. The results supported this prediction. Women experienced more sexual harassment than men, minorities experienced more ethnic harassment than Whites, and minority women experienced more harassment overall than majority men, minority men, and majority women.

  15. Group dynamics.

    Science.gov (United States)

    Scandiffio, A L

    1990-12-01

    Group dynamics play a significant role within any organization, culture, or unit. The important thing to remember with any of these structures is that they are made up of people--people with different ideas, motivations, background, and sometimes different agendas. Most groups, formal or informal, look for a leader in an effort to maintain cohesiveness of the unit. At times, that cultural bond must be developed; once developed, it must be nurtured. There are also times that one of the group no longer finds the culture comfortable and begins to act out behaviorally. It is these times that become trying for the leader as she or he attempts to remain objective when that which was once in the building phase of group cohesiveness starts to fall apart. At all times, the manager must continue to view the employee creating the disturbance as an integral part of the group. It is at this time that it is beneficial to perceive the employee exhibiting problem behaviors as a special employee, as one who needs the benefit of your experience and skills, as one who is still part of the group. It is also during this time that the manager should focus upon her or his own views in the area of power, communication, and the corporate culture of the unit that one has established before attempting to understand another's point of view. Once we understand our own motivation and accept ourselves, it is then that we may move on to offer assistance to another. Once we understand our insecurities recognizing staff dysfunction as a symptom of system dysfunction will not be so threatening to the concept of the manager that we perceive ourselves to be. It takes a secure person to admit that she or he favors staff before deciding to do something to change things. The important thing to know is that it can be done. The favored staff can find a new way of relating to others, the special employee can find new modes of behavior (and even find self-esteem in the process), the group can find new ways

  16. Group representations

    CERN Document Server

    Karpilovsky, G

    1994-01-01

    This third volume can be roughly divided into two parts. The first part is devoted to the investigation of various properties of projective characters. Special attention is drawn to spin representations and their character tables and to various correspondences for projective characters. Among other topics, projective Schur index and projective representations of abelian groups are covered. The last topic is investigated by introducing a symplectic geometry on finite abelian groups. The second part is devoted to Clifford theory for graded algebras and its application to the corresponding theory

  17. Lego Group

    DEFF Research Database (Denmark)

    Møller Larsen, Marcus; Pedersen, Torben; Slepniov, Dmitrij

    2010-01-01

    The last years’ rather adventurous journey from 2004 to 2009 had taught the fifth-largest toy-maker in the world - the LEGO Group - the importance of managing the global supply chain effectively. In order to survive the largest internal financial crisis in its roughly 70 years of existence......, the management had, among many initiatives, decided to offshore and outsource a major chunk of its production to Flextronics. In this pursuit of rapid cost-cutting sourcing advantages, the LEGO Group planned to license out as much as 80 per cent of its production besides closing down major parts...

  18. Informal groups

    NARCIS (Netherlands)

    E. van den Berg; P. van Houwelingen; J. de Hart

    2011-01-01

    Original title: Informele groepen Going out running with a group of friends, rather than joining an official sports club. Individuals who decide to take action themselves rather than giving money to good causes. Maintaining contact with others not as a member of an association, but through an

  19. Congenital double-double lip: A rare case report

    Directory of Open Access Journals (Sweden)

    Swati Phore

    2017-01-01

    Full Text Available A double lip is a rare anomaly characterized by a horizontal fold of redundant mucosal tissue that is situated proximal to the vermilion border. It may be either congenital or acquired and has no gender or race predilection. It occurs most often in the upper lip, although both upper and lower lips are occasionally involved. Surgical intervention (simple excision produces good functional and cosmetic results. In this report, a case of a nonsyndromic congenital maxillary double upper lip and lower lip, both are described. Double lip is of special interest in dental profession as a dental surgeon is normally the first one to diagnose this rare and uncommon condition. Authors hereby discuss a very rare condition in which both upper and lower lips are involved.

  20. Decades with four double triodes; Decades a quatre doubles triodes

    Energy Technology Data Exchange (ETDEWEB)

    Wahl, R [Commissariat a l' Energie Atomique, Lab. du Fort de Chatillon, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1952-07-01

    Decades with four double triodes The described decade consists of four double triodes and four crystals germanium; which has the following characteristics: - Attack in negative impulses. - Sensitivity 12 volts {+-} 40 % for signals of 1 {mu}s about. - Time of resolution 2,5 {mu}s. - Voltage 250 v {+-} 40 %. - heating 6,3 v {+-} 40 %. - Tolerance on the values of the elements of installation 10%. (author) [French] La decade decrite comprend quatre doubles triodes et quatre cristaux germanium; elle a les caracteristiques suivantes: - Attaque en impulsions negatives. - Sensiblite 12 volts {+-} 40 % pour des signaux de 1 {mu}s environ. - Temps de resolution 2,5 {mu}s. - Alimentation 250 v {+-} 40 %. - Chauffage 6,3 v {+-} 40 %. - Tolerance sur les valeurs des elements de montage l0 %. (auteur)

  1. Group Recommendation in Social Networks

    Science.gov (United States)

    2011-01-01

    interests 8,822,921 DOUBAN Largest Chinese community providing user review and recommendation services for movies, books, and music . It also...doubles up as the Chinese language book, movie and music database. 46,850,000 FACEBOOK General 750,000,000+ FLIXSTER Movies 32,000,000 FOURSQUARE...groups, events and community pages) • More than 30 billion pieces of content (web links, news stories, blog posts, notes, photo albums , etc.) shared

  2. Reliability Modeling of Double Beam Bridge Crane

    Science.gov (United States)

    Han, Zhu; Tong, Yifei; Luan, Jiahui; Xiangdong, Li

    2018-05-01

    This paper briefly described the structure of double beam bridge crane and the basic parameters of double beam bridge crane are defined. According to the structure and system division of double beam bridge crane, the reliability architecture of double beam bridge crane system is proposed, and the reliability mathematical model is constructed.

  3. Alternate Double Single Track Lines

    Energy Technology Data Exchange (ETDEWEB)

    Moraga Contreras, P.; Grande Andrade, Z.; Castillo Ron, E.

    2016-07-01

    The paper discusses the advantages and shortcomings of alternate double single track (ADST) lines with respect to double track lines for high speed lines. ADST lines consists of sequences of double and single track segments optimally selected in order to reduce the construction and maintenance costs of railway lines and to optimize the timetables used to satisfy a given demand. The single tracks are selected to coincide with expensive segments (tunnels and viaducts) and the double tracks are chosen to coincide with flat areas and only where they are necessary. At the same time, departure times are adjusted for trains to cross at the cheap double track segments. This alternative can be used for new lines and also for existing conventional lines where some new tracks are to be constructed to reduce travel time (increase speed). The ADST proposal is illustrated with some examples of both types (new lines and where conventional lines exist), including the Palencia-Santander, the Santiago-Valparaíso-Viña del Mar and the Dublin-Belfast lines, where very important reductions (90 %) are obtained, especially where a railway infrastructure already exist. (Author)

  4. On the physics of relativistic double layers

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-06-01

    A model of a strong, time-independent, and relativistic double layer is studied. Besides double layers having the electric field parallel to the current the model also describes a certain type of oblique double layers. The 'Langmuir condition' (ratio of ion current density to electron current density) as well as an expression for the potential drop of the double layer are derived. Furthermore, the distribution of charged particles, electric field, and potential within the double layer are clarified and discussed. It is found that the properties of relativistic double layers differ substantially from the properties of corresponding non-relativistic double layers. (Author)

  5. COMMUNICATIONS GROUP

    CERN Multimedia

    L. Taylor

    2011-01-01

    The CMS Communications Group, established at the start of 2010, has been busy in all three areas of its responsibility: (1) Communications Infrastructure, (2) Information Systems, and (3) Outreach and Education. Communications Infrastructure There are now 55 CMS Centres worldwide that are well used by physicists working on remote CMS shifts, Computing operations, data quality monitoring, data analysis and outreach. The CMS Centre@CERN in Meyrin, is the centre of the CMS offline and computing operations, hosting dedicated analysis efforts such as during the CMS Heavy Ion lead-lead running. With a majority of CMS sub-detectors now operating in a “shifterless” mode, many monitoring operations are now routinely performed from there, rather than in the main Control Room at P5. The CMS Communications Group, CERN IT and the EVO team are providing excellent videoconferencing support for the rapidly-increasing number of CMS meetings. In parallel, CERN IT and ...

  6. Group therapy

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Full text: In his review 'Genesis of Unified Gauge Theories' at the symposium in Honour of Abdus Salam (June, page 23), Tom Kibble of Imperial College, London, looked back to the physics events around Salam from 1959-67. He described how, in the early 1960s, people were pushing to enlarge the symmetry of strong interactions beyond the SU(2) of isospin and incorporate the additional strangeness quantum number. Kibble wrote - 'Salam had students working on every conceivable symmetry group. One of these was Yuval Ne'eman, who had the good fortune and/or prescience to work on SU(3). From that work, and of course from the independent work of Murray Gell- Mann, stemmed the Eightfold Way, with its triumphant vindication in the discovery of the omega-minus in 1964.' Yuval Ne'eman writes - 'I was the Defence Attaché at the Israeli Embassy in London and was admitted by Salam as a part-time graduate student when I arrived in 1958. I started research after resigning from the Embassy in May 1960. Salam suggested a problem: provide vector mesons with mass - the problem which was eventually solved by Higgs, Guralnik, Kibble,.... (as described by Kibble in his article). I explained to Salam that I had become interested in symmetry. Nobody at Imperial College at the time, other than Salam himself, was doing anything in groups, and attention further afield was focused on the rotation - SO(N) - groups. Reacting to my own half-baked schemes, Salam told me to forget about the rotation groups he taught us, and study group theory in depth, directing me to Eugene Dynkin's classification of Lie subalgebras, about which he had heard from Morton Hamermesh. I found Dynkin incomprehensible without first learning about Lie algebras from Henri Cartan's thesis, which luckily had been reproduced by Dynkin in his 1946 thesis, using his diagram method. From a copy of a translation of Dynkin's thesis which I found in the British Museum Library, I

  7. The double switch for atrioventricular discordance.

    Science.gov (United States)

    Brawn, William J

    2005-01-01

    Conventional surgery for atrioventricular discordance usually associated with ventricular arterial discordance leaves the morphologic right ventricle in the systemic circulation. Long-term follow-up results with this approach reveal a high incidence of right ventricular failure. The double switch procedure was introduced to restore the morphologic left ventricle to the systemic circulation. This operation is performed in two main ways: the atrial-arterial switch and the atrial switch plus Rastelli procedure. This double switch approach has been successful at least in the medium term in abolishing morphologic right ventricular failure and its associated tricuspid valve regurgitation. In the atrial-arterial switch group, there is an incidence of morphologic left ventricular dysfunction, sometimes associated with neoaortic valve regurgitation, and the minority of cases need aortic valve replacement. The long-term function of the morphologic left ventricle and the aortic valve need careful surveillance in the future. The atrial-Rastelli group of patients has not in the medium term shown evidence of ventricular dysfunction but will require change on a regular basis of their ventricular to pulmonary artery valved conduits.

  8. The double Brewster angle effect

    Science.gov (United States)

    Thirion-Lefevre, Laetitia; Guinvarc'h, Régis

    2018-01-01

    The Double Brewster angle effect (DBE) is an extension of the Brewster angle to double reflection on two orthogonal dielectric surfaces. It results from the combination of two pseudo-Brewster angles occurring in complementary incidence angles domains. It can be observed for a large range of incidence angles provided that double bounces mechanism is present. As a consequence of this effect, we show that the reflection coefficient at VV polarization can be at least 10 dB lower than the reflection coefficient at HH polarization over a wide range of incidence angle - typically from 20 to 70∘. It is experimentally demonstrated using a Synthetic Aperture Radar (SAR) image that this effect can be seen on buildings and forests. For large buildings, the difference can reach more than 20 dB. xml:lang="fr"

  9. Double-polarizating scanning radiometer

    International Nuclear Information System (INIS)

    Mishev, D.N.; Nazyrski, T.G.

    1986-01-01

    The double-polarizating single-channel scanning radiometer comprises the following serial connected parts: a scanning double-polarizating aerial, a block for polarization separation, a radiometer receiver, an analog-to-digit converter and an information flow forming block. The low frequency input of the radiometer receiver is connected with a control block, which is also connected with a first bus of a microprocessor, the second bus of which is connected with the A-D converter. The control input of the scanning double-polarizating aerial is connected with the first microprocessor bus. The control inputs of the block for polarization separation are linked by an electronic switch with the output of the forming block, the input of which is connected to the first input of the control block. The control inputs of the block for polarization separation are connected with the second and the third input of the information flow forming block. 2 cls

  10. Double-plug seismic connector

    International Nuclear Information System (INIS)

    Annoot, I.R.

    1984-01-01

    The double-plug seismic electric connector comprises an elongated insulating body. A male connector plug is at one end of the body and a female connector plug is at the opposite end of the body. Each plug has a pair of male and female contacts. A pair of spaced axial conductors is embedded within the insulating body for interconnecting the opposite male and female contacts. The inner end of a double-wire cable is embedded within the insulating body and each wire inner end is connected to one of the conductors

  11. Is double-gloving really protective? A comparison between the glove perforation rate among perioperative nurses with single and double gloves during surgery.

    Science.gov (United States)

    Guo, Yue Ping; Wong, Po Ming; Li, Yi; Or, Peggy Pui Lai

    2012-08-01

    Surgical teams rely on surgical gloves as a barrier to protect themselves against blood-borne pathogenic infections during surgery. Double-gloving is adopted by surgeons to tackle the problem of glove perforation. Nevertheless, double-gloving is not practiced commonly by operating room nurses and there are only limited studies about double-gloving that targets only perioperative nurses. The aim of this research was to assess the effectiveness of double-gloving in protecting perioperative nurses by comparing the frequency of glove perforation between single-gloving and double-gloving groups. A prospective and randomized study was performed. Nurses were assigned randomly to single-gloved and double-gloved groups for comparison of the glove perforation rate. Water-leakage and air-inflation tests were used to detect glove perforation. Glove perforations was detected in 10 of 112 sets of single-gloves (8.9%) and 12 of 106 sets of outer gloves in the double-gloved group (11.3%). There was no inner double-glove perforation (0%). Glove perforations were found in 6 and 4 of the 112 sets of single-gloves for the first assistants (5.36%) and the scrub nurses (3.57%), and 5 and 7 of 106 sets of outer gloves in the double-gloved group for the first assistants (4.72%) and the scrub nurses (6.60%), respectively. The average occurrence of perforation was 69.8 minutes (range, 20-110 min) after the beginning of surgery. The sites of perforation were localized mostly on the left middle finger (42%) and the left ring finger (33.3%). Based on the findings of the study, double-gloving is indeed effective in protecting operating room nurses against blood-borne pathogen exposure. It should be introduced as a routine practice. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. COMMUNICATIONS GROUP

    CERN Multimedia

    L. Taylor

    2010-01-01

    The CMS Communications Group, established at the start of 2010, has been strengthening the activities in all three areas of its responsibility: (1) Communications Infrastructure, (2) Information Systems, and (3) Outreach and Education. Communications Infrastructure The Communications Group has invested a lot of effort to support the operations needs of CMS. Hence, the CMS Centres where physicists work on remote CMS shifts, Data Quality Monitoring, and Data Analysis are running very smoothly. There are now 55 CMS Centres worldwide, up from just 16 at the start of CMS data-taking. The latest to join are Imperial College London, the University of Iowa, and the Università di Napoli. The CMS Centre@CERN in Meyrin, which is now full repaired after the major flooding at the beginning of the year, has been at the centre of CMS offline and computing operations, most recently hosting a large fraction of the CMS Heavy Ion community during the lead-lead run. A number of sub-detector shifts can now take pla...

  13. Group play

    DEFF Research Database (Denmark)

    Tychsen, Anders; Hitchens, Michael; Brolund, Thea

    2008-01-01

    Role-playing games (RPGs) are a well-known game form, existing in a number of formats, including tabletop, live action, and various digital forms. Despite their popularity, empirical studies of these games are relatively rare. In particular there have been few examinations of the effects of the v......Role-playing games (RPGs) are a well-known game form, existing in a number of formats, including tabletop, live action, and various digital forms. Despite their popularity, empirical studies of these games are relatively rare. In particular there have been few examinations of the effects...... of the various formats used by RPGs on the gaming experience. This article presents the results of an empirical study, examining how multi-player tabletop RPGs are affected as they are ported to the digital medium. Issues examined include the use of disposition assessments to predict play experience, the effect...... of group dynamics, the influence of the fictional game characters and the comparative play experience between the two formats. The results indicate that group dynamics and the relationship between the players and their digital characters, are integral to the quality of the gaming experience in multiplayer...

  14. COMMUNICATIONS GROUP

    CERN Multimedia

    L. Taylor

    2011-01-01

    The CMS Communications Group has been busy in all three areas of its responsibility: (1) Communications Infrastructure, (2) Information Systems, and (3) Outreach and Education. Communications Infrastructure The 55 CMS Centres worldwide are well used by physicists working on remote CMS shifts, Computing operations, data quality monitoring, data analysis and outreach. The CMS Centre@CERN in Meyrin, is the centre of the CMS Offline and Computing operations, and a number of subdetector shifts can now take place there, rather than in the main Control Room at P5. A new CMS meeting room has been equipped for videoconferencing in building 42, next to building 40. Our building 28 meeting room and the facilities at P5 will be refurbished soon and plans are underway to steadily upgrade the ageing equipment in all 15 CMS meeting rooms at CERN. The CMS evaluation of the Vidyo tool indicates that it is not yet ready to be considered as a potential replacement for EVO. The Communications Group provides the CMS-TV (web) cha...

  15. Double blind clinical trail comparing the safety and efficacy of ...

    African Journals Online (AJOL)

    Double blind clinical trail comparing the safety and efficacy of nimesulide (100g) and diclofenac in osteoarthrosis of the hip and knee joints. ... A significant proportion of the patients in the diclofenac group (50% vs 17.6%) had break through pain that warranted the use of at least two tablets of 500mg of paracetamol per week ...

  16. On Double-Entry Bookkeeping: The Mathematical Treatment

    Science.gov (United States)

    Ellerman, David

    2014-01-01

    Double-entry bookkeeping (DEB) implicitly uses a specific mathematical construction, the group of differences using pairs of unsigned numbers ("T-accounts"). That construction was only formulated abstractly in mathematics in the nineteenth century, even though DEB had been used in the business world for over five centuries. Yet the…

  17. Computer code for double beta decay QRPA based calculations

    Energy Technology Data Exchange (ETDEWEB)

    Barbero, C. A.; Mariano, A. [Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina and Instituto de Física La Plata, CONICET, La Plata (Argentina); Krmpotić, F. [Instituto de Física La Plata, CONICET, La Plata, Argentina and Instituto de Física Teórica, Universidade Estadual Paulista, São Paulo (Brazil); Samana, A. R.; Ferreira, V. dos Santos [Departamento de Ciências Exatas e Tecnológicas, Universidade Estadual de Santa Cruz, BA (Brazil); Bertulani, C. A. [Department of Physics, Texas A and M University-Commerce, Commerce, TX (United States)

    2014-11-11

    The computer code developed by our group some years ago for the evaluation of nuclear matrix elements, within the QRPA and PQRPA nuclear structure models, involved in neutrino-nucleus reactions, muon capture and β{sup ±} processes, is extended to include also the nuclear double beta decay.

  18. Influence of Solo and Double Parenting on the Adjustment Problems ...

    African Journals Online (AJOL)

    This study investigated the influence of solo and double parenting on the adjustment problems of secondary school adolescents. Adolescents\\' adjustment problems were studied under four groups. These include social, family, personal and academic categories. The sample for the study consisted of 630 adolescents made ...

  19. Design studies for the Double Chooz trigger

    International Nuclear Information System (INIS)

    Cucoanes, Andi Sebastian

    2009-01-01

    The main characteristic of the neutrino mixing effect is assumed to be the coupling between the flavor and the mass eigenstates. Three mixing angles (θ 12 , θ 23 , θ 13 ) are describing the magnitude of this effect. Still unknown, θ 13 is considered very small, based on the measurement done by the CHOOZ experiment. A leading experiment will be Double Chooz, placed in the Ardennes region, on the same site as used by CHOOZ. The Double Chooz goal is the exploration of ∝80% from the currently allowed θ 13 region, by searching the disappearance of reactor antineutrinos. Double Chooz will use two similar detectors, located at different distances from the reactor cores: a near one at ∝150 m where no oscillations are expected and a far one at 1.05 km distance, close to the first minimum of the survival probability function. The measurement foresees a precise comparison of neutrino rates and spectra between both detectors. The detection mechanism is based on the inverse β-decay. The Double Chooz detectors have been designed to minimize the rate of random background. In a simplified view, two optically separated regions are considered. The target, filled with Gd-doped liquid scintillator, is the main antineutrino interaction volume. Surrounding the target, the inner veto region aims to tag the cosmogenic muon background which hits the detector. Both regions are viewed by photomultipliers. The Double Chooz trigger system has to be highly efficient for antineutrino events as well as for several types of background. The trigger analyzes discriminated signals from the central region and the inner veto photomultipliers. The trigger logic is fully programmable and can combine the input signals. The trigger conditions are based on the total energy released in event and on the PMT groups multiplicity. For redundancy, two independent trigger boards will be used for the central region, each of them receiving signals from half of the photomultipliers. A third trigger board

  20. Design studies for the Double Chooz trigger

    Energy Technology Data Exchange (ETDEWEB)

    Cucoanes, Andi Sebastian

    2009-07-24

    The main characteristic of the neutrino mixing effect is assumed to be the coupling between the flavor and the mass eigenstates. Three mixing angles ({theta}{sub 12}, {theta}{sub 23}, {theta}{sub 13}) are describing the magnitude of this effect. Still unknown, {theta}{sub 13} is considered very small, based on the measurement done by the CHOOZ experiment. A leading experiment will be Double Chooz, placed in the Ardennes region, on the same site as used by CHOOZ. The Double Chooz goal is the exploration of {proportional_to}80% from the currently allowed {theta}{sub 13} region, by searching the disappearance of reactor antineutrinos. Double Chooz will use two similar detectors, located at different distances from the reactor cores: a near one at {proportional_to}150 m where no oscillations are expected and a far one at 1.05 km distance, close to the first minimum of the survival probability function. The measurement foresees a precise comparison of neutrino rates and spectra between both detectors. The detection mechanism is based on the inverse {beta}-decay. The Double Chooz detectors have been designed to minimize the rate of random background. In a simplified view, two optically separated regions are considered. The target, filled with Gd-doped liquid scintillator, is the main antineutrino interaction volume. Surrounding the target, the inner veto region aims to tag the cosmogenic muon background which hits the detector. Both regions are viewed by photomultipliers. The Double Chooz trigger system has to be highly efficient for antineutrino events as well as for several types of background. The trigger analyzes discriminated signals from the central region and the inner veto photomultipliers. The trigger logic is fully programmable and can combine the input signals. The trigger conditions are based on the total energy released in event and on the PMT groups multiplicity. For redundancy, two independent trigger boards will be used for the central region, each of

  1. Magnetoresistance stories of double perovskites

    Indian Academy of Sciences (India)

    grain surfaces have also been proposed to act as tunnel barriers in Sr2FeMoO6. ... these double perovskites, a gradual decrease in the low-field MR and saturation ... simultaneously, and therefore serious material engineering was needed.

  2. Double Coffee opens in China

    Index Scriptorium Estoniae

    2009-01-01

    Läti suursaadik Ingrida Levrence avas esimese Double Coffee kohviku Hiina pealinnas Pekingi südames. Rahvusvaheline kohvikukett kavatseb laieneda mõne kohviku võrra igal aastal. Seni tegutsetakse Lätis, Eestis, Leedus, Ukrainas ja Valgevenes

  3. Eight Arguments against Double Effect

    DEFF Research Database (Denmark)

    Di Nucci, Ezio

    I offer eight arguments against the Doctrine of Double Effect, a normative principle according to which in pursuing the good it is sometimes morally permissible to bring about some evil as a side-effect or merely foreseen consequence: the same evil would not be morally justified as an intended...

  4. A Double-Minded Fractal

    Science.gov (United States)

    Simoson, Andrew J.

    2009-01-01

    This article presents a fun activity of generating a double-minded fractal image for a linear algebra class once the idea of rotation and scaling matrices are introduced. In particular the fractal flip-flops between two words, depending on the level at which the image is viewed. (Contains 5 figures.)

  5. Double standards with radioactive waste

    International Nuclear Information System (INIS)

    Parkinson, A.

    2002-01-01

    The author claims that whether it is short-lived waste from Commonwealth facilities, long-lived plutonium waste from an atomic bomb test site on Aboriginal land, or reactor waste from Lucas Heights, the Australian government applies double standards to suit its own agenda

  6. Constraining neutrinoless double beta decay

    International Nuclear Information System (INIS)

    Dorame, L.; Meloni, D.; Morisi, S.; Peinado, E.; Valle, J.W.F.

    2012-01-01

    A class of discrete flavor-symmetry-based models predicts constrained neutrino mass matrix schemes that lead to specific neutrino mass sum-rules (MSR). We show how these theories may constrain the absolute scale of neutrino mass, leading in most of the cases to a lower bound on the neutrinoless double beta decay effective amplitude.

  7. Magnetoresistance stories of double perovskites

    Indian Academy of Sciences (India)

    2015-05-28

    May 28, 2015 ... Tunnelling magnetoresistance (TMR) in polycrystalline double perovskites has been an important research topic for more than a decade now, where the nature of the insulating tunnel barrier is the core issue of debate. Other than the nonmagnetic grain boundaries as conventional tunnel barriers, intragrain ...

  8. Doubled-ended ceramic thyratron

    CERN Multimedia

    1974-01-01

    The double-ended ceramic thyratron CX 1171 B, with its coaxial voltage divider for the SPS. Such a switch, paralleled by three ignitrons in series forms the "thyragnitron" arrangement, and can switch 10 kA, 25 ms pulses, with very fast rise times.

  9. Single and double stereoselective fluorination of (E-allylsilanes

    Directory of Open Access Journals (Sweden)

    Tredwell Matthew

    2007-10-01

    Full Text Available Abstract Acyclic allylic monofluorides were prepared by electrophilic fluorination of branched (E-allylsilanes with Selectfluor. These reactions proceeded with efficient transfer of chirality from the silylated to the fluorinated stereocentre. Upon double fluorination, an unsymmetrical ethyl syn-2,5-difluoroalk-3-enoic ester was prepared, the silyl group acting as an anti stereodirecting group for the two C-F bond forming events.

  10. Some theoretical aspects of electrostatic double layers

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1978-11-01

    A review is presented of the main results of the theoretical work on electrostatic double layers. The general properties of double layers are first considered. Then the time-independent double layer is discussed. The discussion deals with the potential drop, the thickness, and some necessary criteria for the existence and stability of the layer. As a complement to the study of the timeindependent double layer a few remarks are also made upon the timedependent double layer. Finally the question of how double layers are formed and maintained is treated. Several possible formation mechanisms are considered. (author)

  11. Will Carbon Tax Yield Employment Double Dividend for China?

    Directory of Open Access Journals (Sweden)

    Jinghua Zhang

    2013-07-01

    Full Text Available Carbon tax is an important economic means to reduce carbon emission. This paper establishes a Computable General Equilibrium (CGE model to reflect China’s resource environment where economic growth and employment play a role by analyzing impacts of carbon tax on employment. The CGE model measures short and long-term impacts of carbon tax on employment, and examines whether the employment “double dividend” would be possible. The analysis shows that the demand for employment tends to decrease as a whole, but different groups of employees would be affected in various ways. “Double dividend” will be possible if appropriate carbon tax cycle is in place.

  12. COMMUNICATIONS GROUP

    CERN Multimedia

    L. Taylor

    2010-01-01

    The recently established CMS Communications Group, led by Lucas Taylor, has been busy in all three of its main are areas of responsibility: Communications Infrastructure, Information Systems, and Outreach and Education Communications Infrastructure The damage caused by the flooding of the CMS Centre@CERN on 21st December has been completely repaired and all systems are back in operation. Major repairs were made to the roofs, ceilings and one third of the floor had to be completely replaced. Throughout these works, the CMS Centre was kept operating and even hosted a major press event for first 7 TeV collisions, as described below. Incremental work behind the scenes is steadily improving the quality of the CMS communications infrastructure, particularly Webcasting, video conferencing, and meeting rooms at CERN. CERN/IT is also deploying a pilot service of a new videoconference tool called Vidyo, to assess whether it might provide an enhanced service at a lower cost, compared to the EVO tool currently in w...

  13. COMMUNICATIONS GROUP

    CERN Multimedia

    L. Taylor

    2011-01-01

    Communications Infrastructure The 55 CMS Centres worldwide are well used by physicists working on remote CMS shifts, Computing operations, data quality monitoring, data analysis and outreach. The CMS Centre@CERN in Meyrin is particularly busy at the moment, hosting about 50 physicists taking part in the heavy-ion data-taking and analysis. Three new CMS meeting room will be equipped for videoconferencing in early 2012: 40/5B-08, 42/R-031, and 28/S-029. The CMS-TV service showing LHC Page 1, CMS Page 1, etc. (http://cmsdoc.cern.ch/cmscc/projector/index.jsp) is now also available for mobile devices: http://cern.ch/mcmstv. Figure 12: Screenshots of CMS-TV for mobile devices Information Systems CMS has a new web site: (http://cern.ch/cms) using a modern web Content Management System to ensure content and links are managed and updated easily and coherently. It covers all CMS sub-projects and groups, replacing the iCMS internal pages. It also incorporates the existing CMS public web site (http:/...

  14. COMMUNICATIONS GROUP

    CERN Multimedia

    L. Taylor

    2012-01-01

      Outreach and Education We are fortunate that our research has captured the public imagination, even though this inevitably puts us under the global media spotlight, as we saw with the Higgs seminar at CERN in December, which had 110,000 distinct webcast viewers. The media interest was huge with 71 media organisations registering to come to CERN to cover the Higgs seminar, which was followed by a press briefing with the DG and Spokespersons. This event resulted in about 2,000 generally positive stories in the global media. For this seminar, the CMS Communications Group prepared up-to-date news and public material, including links to the CMS results, animations and event displays [http://cern.ch/go/Ch8thttp://cern.ch/go/Ch8t]. There were 44,000 page-views on the CMS public website, with the Higgs news article being by far the most popular item. CMS event displays from iSpy are fast becoming the iconic media images, featuring on numerous major news outlets (BBC, CNN, MSN...) as well as in the sci...

  15. Quantum Quenches in a Spinor Condensate

    International Nuclear Information System (INIS)

    Lamacraft, Austen

    2007-01-01

    We discuss the ordering of a spin-1 condensate when quenched from its paramagnetic phase to its ferromagnetic phase by reducing the magnetic field. We first elucidate the nature of the equilibrium quantum phase transition. Quenching rapidly through this transition reveals XY ordering either at a specific wave vector, or the ''light-cone'' correlations familiar from relativistic theories, depending on the end point of the quench. For a quench proceeding at a finite rate the ordering scale is governed by the Kibble-Zurek mechanism. The creation of vortices through growth of the magnetization fluctuations is also discussed. The long-time dynamics again depends on the end point, conserving the order parameter in a zero field, but not at a finite field, with differing exponents for the coarsening of magnetic order. The results are discussed in the light of a recent experiment by Sadler et al

  16. Lightweight Double Neutron Star Found

    Science.gov (United States)

    Kohler, Susanna

    2018-02-01

    More than forty years after the first discovery of a double neutron star, we still havent found many others but a new survey is working to change that.The Hunt for PairsThe observed shift in the Hulse-Taylor binarys orbital period over time as it loses energy to gravitational-wave emission. [Weisberg Taylor, 2004]In 1974, Russell Hulse and Joseph Taylor discovered the first double neutron star: two compact objects locked in a close orbit about each other. Hulse and Taylors measurements of this binarys decaying orbit over subsequent years led to a Nobel prize and the first clear evidence of gravitational waves carrying energy and angular momentum away from massive binaries.Forty years later, we have since confirmed the existence of gravitational waves directly with the Laser Interferometer Gravitational-Wave Observatory (LIGO). Nonetheless, finding and studying pre-merger neutron-star binaries remains a top priority. Observing such systems before they merge reveals crucial information about late-stage stellar evolution, binary interactions, and the types of gravitational-wave signals we expect to find with current and future observatories.Since the Hulse-Taylor binary, weve found a total of 16 additional double neutron-star systems which represents only a tiny fraction of the more than 2,600 pulsars currently known. Recently, however, a large number of pulsar surveys are turning their eyes toward the sky, with a focus on finding more double neutron stars and at least one of them has had success.The pulse profile for PSR J1411+2551 at 327 MHz. [Martinez et al. 2017]A Low-Mass DoubleConducted with the 1,000-foot Arecibo radio telescope in Puerto Rico, the Arecibo 327 MHz Drift Pulsar Survey has enabled the recent discovery of dozens of pulsars and transients. Among them, as reported by Jose Martinez (Max Planck Institute for Radio Astronomy) and coauthors in a recent publication, is PSR J1411+2551: a new double neutron star with one of the lowest masses ever measured

  17. On characters of finite groups

    CERN Document Server

    Broué, Michel

    2017-01-01

    This book explores the classical and beautiful character theory of finite groups. It does it by using some rudiments of the language of categories. Originally emerging from two courses offered at Peking University (PKU), primarily for third-year students, it is now better suited for graduate courses, and provides broader coverage than books that focus almost exclusively on groups. The book presents the basic tools, notions and theorems of character theory (including a new treatment of the control of fusion and isometries), and introduces readers to the categorical language at several levels. It includes and proves the major results on characteristic zero representations without any assumptions about the base field. The book includes a dedicated chapter on graded representations and applications of polynomial invariants of finite groups, and its closing chapter addresses the more recent notion of the Drinfeld double of a finite group and the corresponding representation of GL_2(Z).

  18. Search for new physics with neutrinoless double beta decay

    International Nuclear Information System (INIS)

    Klapdor-Kleingrothaus, H.V.; Baudis, L.; Hellmig, J.; Hirsch, M.; Kolb, S.; Paes, H.; Ramachers, Y.

    1999-01-01

    Neutrinoless double beta decay (0νββ) is one of the most sensitive approaches to test particle physics beyond the standard model. During the last years, besides the most restrictive limit on the effective Majorana neutrino mass, the analysis of new contributions by the Heidelberg group led to bounds on left-right-symmetric models, leptoquarks and R-parity violating models competitive to recent accelerator limits, which are of special interest in view of the HERA anomaly at large Q 2 and x. These new results deduced from the Heidelberg-Moscow double beta decay experiment are reviewed. Also an outlook on the future of double beta decay, the GENIUS proposal, is given

  19. Radiation Protection, double-blind studies with radiopharmaceuticals

    International Nuclear Information System (INIS)

    Pujadas, M. C.; Camacho, C.; Guasp, M.; Villaescusa, J. I.

    2009-01-01

    In a double-blind randomized controlled clinical trial (RCT) subjects and researchers do not know the assignment to treatment groups to ovoid the appearance of subjective biases of information. The employment of radiopharmaceuticals in double-blind RCTs raises a dilemma from the point ov view of the radiological protection. On the one hand, the obligation to act in cases of contamination and/or risk of irradiation exists, but on the other hand the duty of keeping the blind study also exists. In this paper some of the possible problems that arise when conducting a double-blind RCT with radiopharmaceuticals from the point of view of the radiological protection are presented. We comment our experience with the radiopharmaceutical Alpharadin and, in addition, we propose useful recommendations based on the randomness of the decontamination process. (Author) 7 refs.

  20. Monocular Elevation Deficiency - Double Elevator Palsy

    Science.gov (United States)

    ... Español Condiciones Chinese Conditions Monocular Elevation Deficiency/ Double Elevator Palsy En Español Read in Chinese What is monocular elevation deficiency (Double Elevator Palsy)? Monocular Elevation Deficiency, also known by the ...