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Sample records for double edged sword

  1. Fiction, History and Pedagogy: A Double-Edged Sword

    Science.gov (United States)

    Clark, Penney; Sears, Alan

    2017-01-01

    There are many areas of overlap between history and fiction. Teachers of history have long recognized this connection and used a range of fictional accounts in their teaching. In this article, we argue that fiction is a double-edged sword that must be handled carefully. On the one hand, it presents compelling characters and accounts that provide…

  2. Polyphenols as dietary supplements: A double-edged sword

    Directory of Open Access Journals (Sweden)

    Keith R Martin

    2009-12-01

    Full Text Available Keith R Martin, Christy L AppelNutrition Program, Healthy Lifestyles Research Center, College of Nursing and Health Innovation, Arizona State University, Mesa, AZ, USAAbstract: Increased consumption of fruits and vegetables is associated with a lower risk of chronic disease such as cardiovascular disease, some forms of cancer, and neurodegeneration. Pro-oxidant-induced oxidative stress contributes to the pathogenesis of numerous chronic diseases and, as such, dietary antioxidants can quench and/or retard such processes. Dietary polyphenols, ie, phenolic acids and flavonoids, are a primary source of antioxidants for humans and are derived from plants including fruits, vegetables, spices, and herbs. Based on compelling evidence regarding the health effects of polyphenol-rich foods, new dietary supplements and polyphenol-rich foods are being developed for public use. Consumption of such products can increase dietary polyphenol intake and subsequently plasma concentrations beyond expected levels associated with dietary consumption and potentially confer additional health benefits. Furthermore, bioavailability can be modified to further increase absorption and ultimately plasma concentrations of polyphenols. However, the upper limit for plasma concentrations of polyphenols before the elaboration of adverse effects is unknown for many polyphenols. Moreover, a considerable amount of evidence is accumulating which supports the hypothesis that high-dose polyphenols can mechanistically cause adverse effects through pro-oxidative action. Thus, polyphenol-rich dietary supplements can potentially confer additional benefits but high-doses may elicit toxicity thereby establishing a double-edge sword in supplement use.Keywords: antioxidant, bioavailability, flavonoids, polyphenols, supplement

  3. Nodulation outer proteins: double-edged swords of symbiotic rhizobia.

    Science.gov (United States)

    Staehelin, Christian; Krishnan, Hari B

    2015-09-15

    Rhizobia are nitrogen-fixing bacteria that establish a nodule symbiosis with legumes. Nodule formation depends on signals and surface determinants produced by both symbiotic partners. Among them, rhizobial Nops (nodulation outer proteins) play a crucial symbiotic role in many strain-host combinations. Nops are defined as proteins secreted via a rhizobial T3SS (type III secretion system). Functional T3SSs have been characterized in many rhizobial strains. Nops have been identified using various genetic, biochemical, proteomic, genomic and experimental approaches. Certain Nops represent extracellular components of the T3SS, which are visible in electron micrographs as bacterial surface appendages called T3 (type III) pili. Other Nops are T3 effector proteins that can be translocated into plant cells. Rhizobial T3 effectors manipulate cellular processes in host cells to suppress plant defence responses against rhizobia and to promote symbiosis-related processes. Accordingly, mutant strains deficient in synthesis or secretion of T3 effectors show reduced symbiotic properties on certain host plants. On the other hand, direct or indirect recognition of T3 effectors by plant cells expressing specific R (resistance) proteins can result in effector triggered defence responses that negatively affect rhizobial infection. Hence Nops are double-edged swords that may promote establishment of symbiosis with one legume (symbiotic factors) and impair symbiotic processes when bacteria are inoculated on another legume species (asymbiotic factors). In the present review, we provide an overview of our current understanding of Nops. We summarize their symbiotic effects, their biochemical properties and their possible modes of action. Finally, we discuss future perspectives in the field of T3 effector research. © 2015 Authors; published by Portland Press Limited.

  4. microRNA-mediated R gene regulation: molecular scabbards for double-edged swords.

    Science.gov (United States)

    Deng, Yingtian; Liu, Minglei; Li, Xiaofei; Li, Feng

    2018-02-01

    Plant resistance (R) proteins are immune receptors that recognize pathogen effectors and trigger rapid defense responses, namely effector-triggered immunity. R protein-mediated pathogen resistance is usually race specific. During plant-pathogen coevolution, plant genomes accumulated large numbers of R genes. Even though plant R genes provide important natural resources for breeding disease-resistant crops, their presence in the plant genome comes at a cost. Misregulation of R genes leads to developmental defects, such as stunted growth and reduced fertility. In the past decade, many microRNAs (miRNAs) have been identified to target various R genes in plant genomes. miRNAs reduce R gene levels under normal conditions and allow induction of R gene expression under various stresses. For these reasons, we consider R genes to be double-edged "swords" and miRNAs as molecular "scabbards". In the present review, we summarize the contributions and potential problems of these "swords" and discuss the features and production of the "scabbards", as well as the mechanisms used to pull the "sword" from the "scabbard" when needed.

  5. Conditional punishment is a double-edged sword in promoting cooperation.

    Science.gov (United States)

    Huang, Feng; Chen, Xiaojie; Wang, Long

    2018-01-11

    Punishment is widely recognized as an effective approach for averting from exploitation by free-riders in human society. However, punishment is costly, and thus rational individuals are unwilling to take the punishing action, resulting in the second-order free-rider problem. Recent experimental study evidences that individuals prefer conditional punishment, and their punishing decision depends on other members' punishing decisions. In this work, we thus propose a theoretical model for conditional punishment and investigate how such conditional punishment influences cooperation in the public goods game. Considering conditional punishers only take the punishing action when the number of unconditional punishers exceeds a threshold number, we demonstrate that such conditional punishment induces the effect of a double-edged sword on the evolution of cooperation both in well-mixed and structured populations. Specifically, when it is relatively easy for conditional punishers to engage in the punishment activity corresponding to a low threshold value, cooperation can be promoted in comparison with the case without conditional punishment. Whereas when it is relatively difficult for conditional punishers to engage in the punishment activity corresponding to a high threshold value, cooperation is inhibited in comparison with the case without conditional punishment. Moreover, we verify that such double-edged sword effect exists in a wide range of model parameters and can be still observed in other different punishment regimes.

  6. Swords with Blunt Edges

    Science.gov (United States)

    Popham, W. James

    2004-01-01

    Many U.S. educators now wonder whether they're teachers or targets. This mentality stems from the specter of their school being sanctioned for failing the state accountability tests mandated under No Child Left Behind (NCLB). According to this author, most of those tests are like blunt-edged swords: They function badly in two directions. While…

  7. Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?

    LENUS (Irish Health Repository)

    Killeen, S D

    2012-02-03

    The toll-like receptor (TLR) system constitutes a pylogenetically ancient, evolutionary conserved, archetypal pattern recognition system, which underpins pathogen recognition by and activation of the immune system. Toll-like receptor agonists have long been used as immunoadjuvants in anti cancer immunotherapy. However, TLRs are increasingly implicated in human disease pathogenesis and an expanding body of both clinical and experimental evidence suggests that the neoplastic process may subvert TLR signalling pathways to advance cancer progression. Recent discoveries in the TLR system open a multitude of potential therapeutic avenues. Extrapolation of such TLR system manipulations to a clinical oncological setting demands care to prevent potentially deleterious activation of TLR-mediated survival pathways. Thus, the TLR system is a double-edge sword, which needs to be carefully wielded in the setting of neoplastic disease.

  8. Peer pressure is a double-edged sword in vaccination dynamics

    Science.gov (United States)

    Wu, Zhi-Xi; Zhang, Hai-Feng

    2013-10-01

    Whether or not to change behavior depends not only on the personal success of each individual, but also on the success and/or behavior of others. Using this as motivation, we incorporate the impact of peer pressure into a susceptible-vaccinated-infected-recovered (SVIR) epidemiological model, where the propensity to adopt a particular vaccination strategy depends both on individual success as well as on the strategies of neighbors. We show that plugging into the peer pressure is a double-edged sword, which, on the one hand, strongly promotes vaccination when its cost is below a critical value, but, on the other hand, it can also strongly impede it if the critical value is exceeded. We explain this by revealing a facilitated cluster formation process that is induced by the peer pressure. Due to this, the vaccinated individuals are inclined to cluster together and therefore become unable to efficiently inhibit the spread of the infectious disease if the vaccination is costly. If vaccination is cheap, however, they reinforce each other in using it. Our results are robust to variations of the SVIR dynamics on different population structures.

  9. Androgens as double-edged swords: Induction and suppression of follicular development.

    Science.gov (United States)

    Pan, Jie-Xue; Zhang, Jun-Yu; Ke, Zhang-Hong; Wang, Fang-Fang; Barry, John A; Hardiman, Paul J; Qu, Fan

    2015-01-01

    Androgens, which are mediated via the androgen receptor (AR), play important roles in normal follicular development and female fertility. However, just like a double-edged sword, besides the positive effects of androgen on follicular development, abnormal androgen levels, especially as in hyperandrogenism, seriously suppress normal follicular development. A crucial balance exists between the importance of androgens in follicular development and their negative effects when in excess. As the first meiotic division and epigenetic reprogramming are two critical events in oogenesis, abnormal androgen levels or deficiency in androgen/AR signaling in the ovary may affect these vital events. Oocytes have a tendency to develop genomic instability, thus resulting in an increasing incidence of unpredictable adult diseases. Although many studies have explored the effects of androgens and AR on follicular development, the conclusions are controversial and there has been no thorough review of this topic. This review focuses on the roles of androgens in the physiological process of follicular development, summarizes new insights into the roles of androgens in the arrested development of follicles, and discusses the potential risk of adult diseases originating from abnormal follicular androgen levels or androgen receptor signals, which may determine areas for future studies.

  10. Role of Cytokines as a Double-edged Sword in Sepsis

    Science.gov (United States)

    CHAUDHRY, HINA; ZHOU, JUHUA; ZHONG, YIN; ALI, MIR MUSTAFA; MCGUIRE, FRANKLIN; NAGARKATTI, PRAKASH S.; NAGARKATTI, MITZI

    2014-01-01

    Background Sepsis is a deadly immunological disorder and its pathophysiology is still poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory cytokines can be used as diagnostic and therapeutic targets for sepsis. Materials and Methods Recent publications in the MEDLINE database were searched for articles regarding the clinical significance of inflammatory cytokines in sepsis. Results In response to pathogen infection, pro-inflammatory cytokines [interleukin-6 (IL-6), IL-8, IL-18 and tumor necrosis factor-α (TNF-α)] and anti-inflammatory cytokine (IL-10) increased in patients with sepsis. Importantly, a decrease in IL-6 was associated with a better prognosis and overproduction of IL-10 was found to be the main predictor of severity and fatal outcome. Conclusion Both pro-inflammatory and anti-inflammatory cytokines constitute a double-edged sword in sepsis; on one hand they are critical to eliminate the infection while on the other, excessive production can cause tissue and organ damage. Increase in cytokines such as IL-6, Il-8, IL-10, IL-18 and TNF-α may have implications in diagnosis and treatment of sepsis. PMID:24292568

  11. Breaking the Double-Edged Sword of Effort/Trying Hard: Developmental Equilibrium and Longitudinal Relations among Effort, Achievement, and Academic Self-Concept

    Science.gov (United States)

    Marsh, Herbert W.; Pekrun, Reinhard; Lichtenfeld, Stephanie; Guo, Jiesi; Arens, A. Katrin; Murayama, Kou

    2016-01-01

    Ever since the classic research of Nicholls (1976) and others, effort has been recognized as a double-edged sword: while it might enhance achievement, it undermines academic self-concept (ASC). However, there has not been a thorough evaluation of the longitudinal reciprocal effects of effort, ASC, and achievement, in the context of modern…

  12. The double-edged sword of grandiose narcissism: implications for successful and unsuccessful leadership among U.S. Presidents.

    Science.gov (United States)

    Watts, Ashley L; Lilienfeld, Scott O; Smith, Sarah Francis; Miller, Joshua D; Campbell, W Keith; Waldman, Irwin D; Rubenzer, Steven J; Faschingbauer, Thomas J

    2013-12-01

    Recent research and theorizing suggest that narcissism may predict both positive and negative leadership behaviors. We tested this hypothesis with data on the 42 U.S. presidents up to and including George W. Bush, using (a) expert-derived narcissism estimates, (b) independent historical surveys of presidential performance, and (c) largely or entirely objective indicators of presidential performance. Grandiose, but not vulnerable, narcissism was associated with superior overall greatness in an aggregate poll; it was also positively associated with public persuasiveness, crisis management, agenda setting, and allied behaviors, and with several objective indicators of performance, such as winning the popular vote and initiating legislation. Nevertheless, grandiose narcissism was also associated with several negative outcomes, including congressional impeachment resolutions and unethical behaviors. We found that presidents exhibit elevated levels of grandiose narcissism compared with the general population, and that presidents' grandiose narcissism has been rising over time. Our findings suggest that grandiose narcissism may be a double-edged sword in the leadership domain.

  13. Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia.

    Science.gov (United States)

    Than, Nandor Gabor; Romero, Roberto; Balogh, Andrea; Karpati, Eva; Mastrolia, Salvatore Andrea; Staretz-Chacham, Orna; Hahn, Sinuhe; Erez, Offer; Papp, Zoltan; Kim, Chong Jai

    2015-05-01

    Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.

  14. Facebook and its effects on users' empathic social skills and life satisfaction: a double-edged sword effect.

    Science.gov (United States)

    Chan, Terri H

    2014-05-01

    This study examines how Facebook usage affects individual's empathic social skills and life satisfaction. Following the self-presentational theory, the study explores a key component of the Internet paradox-whether Facebook suppresses or enhances users' interpersonal competence (specifically empathic social skills), given their respective personality makeup. Going further, the study assesses these events' subsequent impacts on users' psychological well-being. Analogous to a double-edged sword, Facebook activities are hypothesized to suppress the positive effect of a user's extraversion orientation on empathic social skills but lessen the negative effect of neuroticism on these skills. The study examines a sample of college-aged Facebook users (n=515), who responded to a large-scale online survey. The findings from a structural equation modeling analysis indicate that while empathic social skills are positively associated with life satisfaction, Facebook activities mainly exert suppression effects. Only upon low usage can Facebook activities lessen the negative effect of neuroticism on empathic social skills, suggesting that Facebook may appear as a less threatening platform for social interactions among neurotics. Yet, results in general suggest that undesirable effects may occur at high levels of Facebook usage whereby both extroverted and neurotic users displace real world social ties to online ones. The findings point to the complex ways in which social media usage may impact the livelihood of users.

  15. Medical ideology as a double-edged sword: the politics of cure and care in the making of Alzheimer's disease.

    Science.gov (United States)

    Chaufan, Claudia; Hollister, Brooke; Nazareno, Jennifer; Fox, Patrick

    2012-03-01

    This paper builds on our prior work concerning the emergence of Alzheimer's disease (AD) as a major social and health concern. Our study was conducted in two phases (1985-1987 and 2009-2011). We examined the historical evolution of the concept of AD and the emergence of the AD social movement in the U. S. Sources include interviews with movement leaders and scientists, historical documents of the Alzheimer's Association, Congressional records, and published literature. We identified recurrent themes and salient issues motivating those in the movement, its barriers and facilitators, and the roles of government and NGOs in the creation of an organizational structure to maintain it. The characterization of AD as a leading cause of death among the elderly was crucial to sustaining the movement, but also operated as a "double edged sword". By construing "senility" as a treatable, even curable biomedical entity, the movement substantively contributed to the notion of an impending "crisis" of the aging population to be avoided at all costs, compounding the effect of conservative federal policies that emphasized the treatment or cure of AD, and less so the long-term care service needs of sufferers and caregivers that had given rise to the movement. We also discuss how the continuing hegemony of the medical model establishes a race against the demographic clock, pitting advances in biomedical research against the needs of an aging population. We propose that alternative framings and sources of legitimization are critical to address the needs and preserve the humanity of people living with AD and their caregivers. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. The double-edged sword: financial source of household healthcare expenditure in Ghana

    Directory of Open Access Journals (Sweden)

    Henry Armah Tagoe

    2012-08-01

    Full Text Available In many regions, some of the most formidable enemies of health are joining forces with the allies of poverty to impose a double burden of disease, disability and premature death. This paper looks at the main financial sources households use to finance healthcare in Ghana. It examines the spatial and socio-economic dynamics and the challenges these pose to health and development. Analysis of the 2003 Ghana World Health Survey data indicates that approximately 41% of households depend on more than one financial source with 88% depending on household income to finance healthcare expenditure. The high dependency on household income will erode gains in the economic and health sector in the midst of the recent global economic recession. Comprehensive national health insurance programs that cover emerging disease conditions will mitigate the double burden of disease on households in emerging economies.

  17. Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

    Directory of Open Access Journals (Sweden)

    Naihan Xu

    2012-01-01

    Full Text Available The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth-factor-activated Akt signalling promotes progression through normal, unperturbed cell cycles by acting on diverse downstream factors involved in controlling the G1/S and G2/M transitions. Remarkably, several recent studies have also implicated Akt in modulating DNA damage responses and genome stability. High Akt activity can suppress ATR/Chk1 signalling and homologous recombination repair (HRR via direct phosphorylation of Chk1 or TopBP1 or, indirectly, by inhibiting recruitment of double-strand break (DSB resection factors, such as RPA, Brca1, and Rad51, to sites of damage. Loss of checkpoint and/or HRR proficiency is therefore a potential cause of genomic instability in tumor cells with high Akt. Conversely, Akt is activated by DNA double-strand breaks (DSBs in a DNA-PK- or ATM/ATR-dependent manner and in some circumstances can contribute to radioresistance by stimulating DNA repair by nonhomologous end joining (NHEJ. Akt therefore modifies both the response to and repair of genotoxic damage in complex ways that are likely to have important consequences for the therapy of tumors with deregulation of the PI3K-Akt-PTEN pathway.

  18. Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities.

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    Mocellin, Simone; Bronte, Vincenzo; Nitti, Donato

    2007-05-01

    Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and pathological processes. The last decade has witnessed major advances in dissecting NO biology and its role in cancer pathogenesis. However, the complexity of the interactions between different levels of NO and several aspects of tumor development/progression has led to apparently conflicting findings. Furthermore, both anti-NO and NO-based anticancer strategies appear effective in several preclinical models. This paradoxical dichotomy is leaving investigators with a double challenge: to determine the net impact of NO on cancer behavior and to define the therapeutic role of NO-centered anticancer strategies. Only a comprehensive and dynamic view of the cascade of molecular and cellular events underlying tumor biology and affected by NO will allow investigators to exploit the potential antitumor properties of drugs interfering with NO metabolism. Available data suggest that NO should be considered neither a universal target nor a magic bullet, but rather a signal transducer to be modulated according to the molecular makeup of each individual cancer and the interplay with conventional antineoplastic agents. (c) 2006 Wiley Periodicals, Inc.

  19. DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair

    Directory of Open Access Journals (Sweden)

    Elisa Mentegari

    2016-08-01

    Full Text Available DNA is constantly exposed to both endogenous and exogenous damages. More than 10,000 DNA modifications are induced every day in each cell’s genome. Maintenance of the integrity of the genome is accomplished by several DNA repair systems. The core enzymes for these pathways are the DNA polymerases. Out of 17 DNA polymerases present in a mammalian cell, at least 13 are specifically devoted to DNA repair and are often acting in different pathways. DNA polymerases β and λ are involved in base excision repair of modified DNA bases and translesion synthesis past DNA lesions. Polymerase λ also participates in non-homologous end joining of DNA double-strand breaks. However, recent data have revealed that, depending on their relative levels, the cell cycle phase, the ratio between deoxy- and ribo-nucleotide pools and the interaction with particular auxiliary proteins, the repair reactions carried out by these enzymes can be an important source of genetic instability, owing to repair mistakes. This review summarizes the most recent results on the ambivalent properties of these enzymes in limiting or promoting genetic instability in mammalian cells, as well as their potential use as targets for anticancer chemotherapy.

  20. DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.

    Science.gov (United States)

    Mentegari, Elisa; Kissova, Miroslava; Bavagnoli, Laura; Maga, Giovanni; Crespan, Emmanuele

    2016-08-31

    DNA is constantly exposed to both endogenous and exogenous damages. More than 10,000 DNA modifications are induced every day in each cell's genome. Maintenance of the integrity of the genome is accomplished by several DNA repair systems. The core enzymes for these pathways are the DNA polymerases. Out of 17 DNA polymerases present in a mammalian cell, at least 13 are specifically devoted to DNA repair and are often acting in different pathways. DNA polymerases β and λ are involved in base excision repair of modified DNA bases and translesion synthesis past DNA lesions. Polymerase λ also participates in non-homologous end joining of DNA double-strand breaks. However, recent data have revealed that, depending on their relative levels, the cell cycle phase, the ratio between deoxy- and ribo-nucleotide pools and the interaction with particular auxiliary proteins, the repair reactions carried out by these enzymes can be an important source of genetic instability, owing to repair mistakes. This review summarizes the most recent results on the ambivalent properties of these enzymes in limiting or promoting genetic instability in mammalian cells, as well as their potential use as targets for anticancer chemotherapy.

  1. The double-edged sword of genetic accounts of criminality: causal attributions from genetic ascriptions affect legal decision making.

    Science.gov (United States)

    Cheung, Benjamin Y; Heine, Steven J

    2015-12-01

    Much debate exists surrounding the applicability of genetic information in the courtroom, making the psychological processes underlying how people consider this information important to explore. This article addresses how people think about different kinds of causal explanations in legal decision-making contexts. Three studies involving a total of 600 Mechanical Turk and university participants found that genetic, versus environmental, explanations of criminal behavior lead people to view the applicability of various defense claims differently, perceive the perpetrator's mental state differently, and draw different causal attributions. Moreover, mediation and path analyses highlight the double-edged nature of genetic attributions-they simultaneously reduce people's perception of the perpetrator's sense of control while increasing people's tendencies to attribute the cause to internal factors and to expect the perpetrator to reoffend. These countervailing relations, in turn, predict sentencing in opposite directions, although no overall differences in sentencing or ultimate verdicts were found. © 2015 by the Society for Personality and Social Psychology, Inc.

  2. A Double-Edged Sword: A Review of Benefits and Risks of Online Nonsuicidal Self-Injury Activities.

    Science.gov (United States)

    Lewis, Stephen P; Seko, Yukari

    2016-03-01

    This review aimed to synthesize current evidence on the perceived benefits and risks of online activity pertinent to nonsuicidal self-injury (NSSI). A systematic literature search was conducted to identify peer-reviewed articles, which yielded a total of 27 articles published between 2005 and 2015. Following this, a thematic analysis was employed to identify perceived benefits and risks of online NSSI activity. Our thematic analysis identified 4 potential benefits (mitigation of social isolation, recovery encouragement, emotional self-disclosure, curbing NSSI urges) and 3 potential risks (NSSI reinforcement, triggering NSSI urges, stigmatization of NSSI) associated with online NSSI activities. Given the double-edged effect of online NSSI activities, clinicians may benefit from incorporating clients' online NSSI activity in the context of NSSI assessment and treatment. Future research ought to directly examine the link between online NSSI activity and NSSI behavior to better understand the nature of these benefits and risks. © 2015 Wiley Periodicals, Inc.

  3. Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'.

    Science.gov (United States)

    McLachlan, Sandra M; Aliesky, Holly A; Chen, Chun-Rong; Chong, Gao; Rapoport, Basil

    2012-01-01

    Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before immunization with adenovirus encoding the A-subunit (A-sub-Ad) breaks tolerance, inducing extensive thyroid lymphocytic infiltration, thyroid damage and antibody spreading to other thyroid proteins. In contrast, no thyroiditis develops in Hi-expressor transgenics or wild-type mice. Our present goal was to determine if thyroiditis could be induced in Hi-expressor transgenics using a more potent immunization protocol: Treg depletion, priming with Complete Freund's Adjuvant (CFA) + A-subunit protein and further Treg depletions before two boosts with A-sub-Ad. As controls, anti-CD25 treated Hi- and Lo-expressors and wild-type mice were primed with CFA+ mouse thyroglobulin (Tg) or CFA alone before A-sub-Ad boosting. Thyroiditis developed after CFA+A-subunit protein or Tg and A-sub-Ad boosting in Lo-expressor transgenics but Hi- expressors (and wild-type mice) were resistant to thyroiditis induction. Importantly, in Lo-expressors, thyroiditis was associated with the development of antibodies to the mouse TSHR downstream of the A-subunit. Unexpectedly, we observed that the effect of bacterial products on the immune system is a "double-edged sword". On the one hand, priming with CFA (mycobacteria emulsified in oil) plus A-subunit protein broke tolerance to the A-subunit in Hi-expressor transgenics leading to high TSHR antibody levels. On the other hand, prior treatment with CFA in the absence of A-subunit protein inhibited responses to subsequent immunization with A-sub-Ad. Consequently, adjuvant activity arising in vivo after bacterial infections combined with a protein autoantigen can break self-tolerance but in the absence of the autoantigen, adjuvant activity can inhibit the induction of immunity to autoantigens (like the

  4. A double-edged sword: advantages and disadvantages to the current emphasis on biogenetic causes of child psychopathology.

    Science.gov (United States)

    Burt, S Alexandra

    2015-02-01

    Research on child psychopathology is a largely biogenetic endeavor these days, at least according to current funding priorities at the National Institutes of Health in the US. This heavy focus on genetic contributions to child psychopathology has some real advantages. Available research has conclusively indicated that child and adolescent mental health problems are partially genetic in origin and, moreover, are related to neural structure and function (as an example, see Plomin et al.). Moreover, these genetic effects may be responsible for some previously reported 'environmental' effects, such that, what appear to be direct environmental risk factors may in fact reflect genetic/familial risks. As one example, Sengupta et al. (this issue) found that maternal smoking during pregnancy was in fact a marker of maternal and paternal psychopathology. Put another way, the association between ADHD and maternal smoking during pregnancy may index a genetic/familial risk for a more severe form of ADHD, rather than a direct effect of uterine exposure to cigarettes. A final, more subtle reason for the current trend towards biogenetic research is that it has the rarely-discussed but all-too-important 'allure of the unknown'. We have only just recently been able to directly explore the biological underpinnings of psychopathology; and as technology advances, so too will the insights gained (presumably). This offers both funding agencies and individual scientists the very real possibility of making a major new discovery - a siren's call for most of us. In sharp contrast, decades of research have explored putatively environmental contributions to child and adolescent psychopathology. New paradigm-shifting discoveries are thus likely to be fewer in number and farther between (if we continue using traditional study designs that omit joint consideration of biology, that is). In short, biogenetic research just feels more cutting edge at the moment. The clear merits of such work

  5. A Double-edged Sword

    DEFF Research Database (Denmark)

    Geisler Asmussen, Christian; Foss, Nicolai Juul; Nell, Phillip Christopher

    expectations among subunit managers. Our analysis of the dynamic game between HQ and subunits has novel and non-intuitive results. For example, we find that good parenting may involve forgoing opportunities for value-creation, and that procedural justice systems may sometimes be counterproductive. Our findings......Multi-business firms should design the task portfolio of their headquarters (HQ) and the way HQ tasks are carried out so that net value creation results. While the strategic management literature has emphasized such parenting benefits, less attention has been paid to the costs that may...... inadvertently be caused by HQ actions. Using a simple game theory model, we analyze the motivational costs that may result from HQ intervention in subunits. Along the lines of the procedural justice literature, we identify the conditions under which these costs may be influenced by the existence of fairness...

  6. Cyberknife: A double edged sword?

    International Nuclear Information System (INIS)

    Joseph, B.; Ramachandra, A.; Supeb, S. S.

    2010-01-01

    The Cyberknife represents a new, frame less stereotactic radiosurgery system which efficiently incorporates advance robotics with computerized image reconstruction to allow highly conformal image guided radiation delivery. This review focus is on the pros and cons of this new radiotherapy tool, its current indications, safety profile and future directions. A literature search of Medline, Pubmed, Biomed, Medscape and Cancer lit database were referred to retrieve relevant data/information. The authors conclude that the use of this system offers an invaluable solution to the treatment of selective tumours/lesions located close to critical structures, salvage of recurrent and metastatic lesions and potential of treatment of selective early stage malignancies like the carcinoma prostate and lung. However, it is still too premature, with insufficient follow up data to advocate it as the treatment of choice in any set up. There are several radiobiological issues that also remain in the grey zone. (authors)

  7. Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

    Directory of Open Access Journals (Sweden)

    Jaouad Bouayed

    2010-01-01

    Full Text Available The balance between oxidation and antioxidation is believed to be critical in maintaining healthy biological systems. Under physiological conditions, the human antioxidative defense system including e.g., superoxide dismutase (SOD, catalase (CAT, glutathione peroxidase (GPx, glutathione (GSH and others, allows the elimination of excess reactive oxygen species (ROS including, among others superoxide anions (O2.-, hydroxyl radicals (OH., alkoxyl radicals (RO. and peroxyradicals (ROO.. However, our endogenous antioxidant defense systems are incomplete without exogenous originating reducing compounds such as vitamin C, vitamin E, carotenoids and polyphenols, playing an essential role in many antioxidant mechanisms in living organisms. Therefore, there is continuous demand for exogenous antioxidants in order to prevent oxidative stress, representing a disequilibrium redox state in favor of oxidation. However, high doses of isolated compounds may be toxic, owing to prooxidative effects at high concentrations or their potential to react with beneficial concentrations of ROS normally present at physiological conditions that are required for optimal cellular functioning. This review aims to examine the double-edged effects of dietary originating antioxidants with a focus on the most abundant compounds, especially polyphenols, vitamin C, vitamin E and carotenoids. Different approaches to enrich our body with exogenous antioxidants such as via synthetic antioxidants, diets rich in fruits and vegetables and taking supplements will be reviewed and experimental and epidemiological evidences discussed, highlighting that antioxidants at physiological doses are generally safe, exhibiting interesting health beneficial effects.

  8. Graphene toxicity as a double-edged sword of risks and exploitable opportunities: a critical analysis of the most recent trends and developments

    Science.gov (United States)

    Volkov, Yuri; McIntyre, Jennifer; Prina-Mello, Adriele

    2017-06-01

    Increased production volumes and a broadening application spectrum of graphene have raised concerns about its potential adverse effects on human health. Numerous reports demonstrate that graphene irrespective of its particular form exerts its effects on a widest range of living organisms, including prokaryotic bacteria and viruses, plants, micro- and macro-invertebrates, mammalian and human cells and whole animals in vivo. However, the available experimental data is frequently a matter of significant divergence and even controversy. Therefore, we provide here a critical analysis of the most recent (2015-2016) reports accumulated in the graphene-related materials biocompatibility and toxicology field in order to elucidate the cutting edge achievements, emerging trends and future opportunities in the area. Experimental findings from the diverse in vitro and in vivo model systems are analysed in the context of the most likely graphene exposure scenarios, such as respiratory inhalation, ingestion route, parenteral administration and topical exposure through the skin. Key factors influencing the toxicity of graphene and its complex derivatives as well as potential risk mitigation approaches exploiting graphene physicochemical properties, surface modifications and possible degradation pathways are also discussed along with its emerging applications for healthcare, diagnostics and innovative therapeutic approaches.

  9. Computer games: a double-edged sword?

    Science.gov (United States)

    Sun, De-Lin; Ma, Ning; Bao, Min; Chen, Xang-Chuan; Zhang, Da-Ren

    2008-10-01

    Excessive computer game playing (ECGP) has already become a serious social problem. However, limited data from experimental lab studies are available about the negative consequences of ECGP on players' cognitive characteristics. In the present study, we compared three groups of participants (current ECGP participants, previous ECGP participants, and control participants) on a Multiple Object Tracking (MOT) task. The previous ECGP participants performed significantly better than the control participants, which suggested a facilitation effect of computer games on visuospatial abilities. Moreover, the current ECGP participants performed significantly worse than the previous ECGP participants. This more important finding indicates that ECGP may be related to cognitive deficits. Implications of this study are discussed.

  10. Characterization of a Messer – The late-Medieval single-edged sword of Central Europe

    International Nuclear Information System (INIS)

    Fajfar, Peter; Medved, Jožef; Klančnik, Grega; Lazar, Tomaž; Nečemer, Marijan; Mrvar, Primož

    2013-01-01

    Metallurgical characterization of a sword blade fragments dating from the second half of the 15th century found in central Slovenia was performed in order to determine its chemical composition, microstructure, microhardness, and to obtain insight into the methods of manufacture of a late-medieval Messer sword. As the artefact was broken, examinations were limited to six very small fragments that were allowed to be removed from the cutting edge, core and the back of the blade. Light optical microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, energy dispersive X-ray fluorescence spectrometry, differential scanning calorimetry, thermodynamics approach and Vickers micro-hardness tests were employed to analyze the microstructure and mechanical properties. The results show that the sword was manufactured from a single wrought iron billet. The surface of the sword was carburized. No evidence of quenching was found. The ferritic microstructure is concentrated in the core, and the pearlitic in the outer layer of the blade. All metal fragments contained non-metallic inclusions that were derived mostly from slag and some from hammer scale. - Highlights: • A metallurgical characterization of a medieval sword blade has been performed. • The carbon content decreased from the surface to the core of the blade. • The dominant microstructure in the outer layer is pearlite and in the core is ferrite. • The presence of lump shaped and elongated non-metallic inclusions was observed. • The sword was manufactured from a single wrought iron billet

  11. Characterization of a Messer – The late-Medieval single-edged sword of Central Europe

    Energy Technology Data Exchange (ETDEWEB)

    Fajfar, Peter; Medved, Jožef; Klančnik, Grega [Department of Materials and Metallurgy, Faculty of Natural Sciences and Engineering, University of Ljubljana, Aškerčeva cesta 12, SI-1000 Ljubljana (Slovenia); Lazar, Tomaž [National Museum of Slovenia, Prešernova cesta 20, SI-1000 Ljubljana (Slovenia); Nečemer, Marijan [Jožef Stefan Institut, Jamova cesta 39, SI-1000 Ljubljana (Slovenia); Mrvar, Primož, E-mail: primoz.mrvar@omm.ntf.uni-lj.si [Department of Materials and Metallurgy, Faculty of Natural Sciences and Engineering, University of Ljubljana, Aškerčeva cesta 12, SI-1000 Ljubljana (Slovenia)

    2013-12-15

    Metallurgical characterization of a sword blade fragments dating from the second half of the 15th century found in central Slovenia was performed in order to determine its chemical composition, microstructure, microhardness, and to obtain insight into the methods of manufacture of a late-medieval Messer sword. As the artefact was broken, examinations were limited to six very small fragments that were allowed to be removed from the cutting edge, core and the back of the blade. Light optical microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, energy dispersive X-ray fluorescence spectrometry, differential scanning calorimetry, thermodynamics approach and Vickers micro-hardness tests were employed to analyze the microstructure and mechanical properties. The results show that the sword was manufactured from a single wrought iron billet. The surface of the sword was carburized. No evidence of quenching was found. The ferritic microstructure is concentrated in the core, and the pearlitic in the outer layer of the blade. All metal fragments contained non-metallic inclusions that were derived mostly from slag and some from hammer scale. - Highlights: • A metallurgical characterization of a medieval sword blade has been performed. • The carbon content decreased from the surface to the core of the blade. • The dominant microstructure in the outer layer is pearlite and in the core is ferrite. • The presence of lump shaped and elongated non-metallic inclusions was observed. • The sword was manufactured from a single wrought iron billet.

  12. Crystallographic Analysis of a Japanese Sword by using Bragg Edge Transmission Spectroscopy

    Science.gov (United States)

    Shiota, Yoshinori; Hasemi, Hiroyuki; Kiyanagi, Yoshiaki

    Neutron imaging using a pulsed neutron source can give crystallographic information over wide area of a sample by analysing position dependent transmission spectra. With the use of a Bragg edge imaging method we non-destructively obtained crystallographic information of a Japanese sword, signed by Bishu Osafune Norimitsu, in order to know position dependent crystallographic characteristics and to check usefulness of the method for the Japanese sword investigation. Strong texture appeared on the back side. On the other hand in the middle area almost isotropic feature appeared and edge side showed feature between them. Rather isotropic area in the centre area gradually reduced from the grip side to the tip side. The crystallite size was smaller near the edge and became larger towards the back side. The smaller crystallite size will be due to quenching around the edge and this trend disappeared in the grip (nakago) area. The larger crystallite size will be due to strong hammering. Coarse grains were also observed directly as transmission images with the use of a high spatial resolution detector. The spatial distribution of the grains was not uniform but the reason have not been understood. Furthermore, a white area around a tip area was proved to be a void by looking at the Brag edge transmission spectra. This void may be formed during forging process of two kinds of steel. It is suggested that consideration on differences in the texture and the crystallite size depending on position will give information to clarify the manufacturing process, and Bragg edge analysis will be a profitable tool for research of Japanese sword.

  13. Examining calling as a double-edged sword for employability

    NARCIS (Netherlands)

    Lysova, Evgenia I.; Jansen, Paul G.W.; Khapova, Svetlana N.; Plomp, Judith; Tims, Maria

    2018-01-01

    Using a two-study design (total N = 1232), this paper examines the relationship between calling and employability. We suggest that, on the one hand, calling can positively relate to employability due to individuals’ engagement in proactive professional development (PPD). On the other hand, calling

  14. Hypothalamic inflammation: a double-edged sword to nutritional diseases

    Science.gov (United States)

    Cai, Dongsheng; Liu, Tiewen

    2015-01-01

    The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and non-neuronal cells in these hypothalamic regions act supportively to execute metabolic regulations. Under conditions of brain and hypothalamic inflammation, which may result from overnutrition-induced intracellular stresses or disease-associated systemic inflammatory factors, extracellular and intracellular environments of hypothalamic cells are disrupted, leading to central metabolic dysregulations and various diseases. Recent research has begun to elucidate the effects of hypothalamic inflammation in causing diverse components of metabolic syndrome leading to diabetes and cardiovascular disease. These new understandings have provocatively expanded previous knowledge on the cachectic roles of brain inflammatory response in diseases, such as infections and cancers. This review describes the molecular and cellular characteristics of hypothalamic inflammation in metabolic syndrome and related diseases as opposed to cachectic diseases, and also discusses concepts and potential applications of inhibiting central/hypothalamic inflammation to treat nutritional diseases. PMID:22417140

  15. Extracellular DNA and histones: double-edged swords in immunothrombosis.

    Science.gov (United States)

    Gould, T J; Lysov, Z; Liaw, P C

    2015-06-01

    The existence of extracellular DNA in human plasma, also known as cell-free DNA (cfDNA), was first described in the 1940s. In recent years, there has been a resurgence of interest in the functional significance of cfDNA, particularly in the context of neutrophil extracellular traps (NETs). cfDNA and histones are key components of NETs that aid in the host response to infection and inflammation. However, cfDNA and histones may also exert harmful effects by triggering coagulation, inflammation, and cell death and by impairing fibrinolysis. In this article, we will review the pathologic nature of cfDNA and histones in macrovascular and microvascular thrombosis, including venous thromboembolism, cancer, sepsis, and trauma. We will also discuss the prognostic value of cfDNA and histones in these disease states. Understanding the molecular and cellular pathways regulated by cfDNA and histones may provide novel insights to prevent pathological thrombus formation and vascular occlusion. © 2015 International Society on Thrombosis and Haemostasis.

  16. The "Double-Edged Sword" of the Adult Learning Environment

    Science.gov (United States)

    Murray, Sara; Mitchell, Jane

    2013-01-01

    The vocational education and training sector plays a critical role in the provision of educational opportunities for young adults who have left school prior to completing a qualification. Some research has found that a major factor that supports student re-engagement in formal education is the "adult learning environment" that…

  17. Adolescent Controversial Status Brokers: A Double-Edged Sword

    Science.gov (United States)

    Borowski, Sarah; Zeman, Janice; Carboni, Inga; Gilman, Rich; Thrash, Todd

    2017-01-01

    Using a 3-wave longitudinal, multidimensional approach, this study investigated the influence of social network position and social status on the psychosocial outcomes of 440 youth (45.1% girls; M[subscript age] = 16.1 years; 90.9% Caucasian) over 26 months, focusing on the controversial status classification (i.e., youth who are highly liked and…

  18. Language Teacher Immunity: A Double-Edged Sword

    Science.gov (United States)

    Hiver, Phil; Dörnyei, Zoltán

    2017-01-01

    In this paper we introduce a new concept termed "teacher immunity". We propose that this immunity emerges from the accrued experiences of coping with disturbances and problems in stressful teaching environments, and that it functions as an indispensable protective armor allowing language teachers to survive the unavoidable hassles of…

  19. Enzyme cofactors: Double-edged sword for catalysis

    Science.gov (United States)

    Ivanov, Ivaylo

    2013-01-01

    The metal cofactors responsible for the activity of CDK2 -- a representative member of the kinase superfamily of enzymes -- have now been shown to also have inhibitory effects during the catalytic cycle.

  20. Concrete Instantiations of Mathematics: A Double-Edged Sword

    Science.gov (United States)

    Kaminski, Jennifer A.; Sloutsky, Vladimir M.; Heckler, Andrew F.

    2009-01-01

    What factors affect transfer of knowledge is a complex question. In recent research, the authors demonstrated that concreteness of the learning domain is one such factor (Kaminski, Sloutsky, & Heckler, 2008). Even when prompted and given no time delay, participants who learned a concrete instantiation of a mathematical concept failed to…

  1. Neutrophil extracellular traps: double-edged swords of innate immunity.

    Science.gov (United States)

    Kaplan, Mariana J; Radic, Marko

    2012-09-15

    Spectacular images of neutrophils ejecting nuclear chromatin and bactericidal proteins, in response to microbes, were first reported in 2004. As externalized chromatin could entangle bacteria, these structures were named neutrophil extracellular traps (NETs). Subsequent studies identified microorganisms and sterile conditions that stimulate NETs, as well as additional cell types that release extracellular chromatin. The release of NETs is the most dramatic stage in a cell death process called NETosis. Experimental evidence suggests that NETs participate in pathogenesis of autoimmune and inflammatory disorders, with proposed involvement in glomerulonephritis, chronic lung disease, sepsis, and vascular disorders. Exaggerated NETosis or diminished NET clearance likely increases risk of autoreactivity to NET components. The biological significance of NETs is just beginning to be explored. A more complete integration of NETosis within immunology and pathophysiology will require better understanding of NET properties associated with specific disease states and microbial infections. This may lead to the identification of important therapeutic targets.

  2. Vitamin D in Vascular Calcification: A Double-Edged Sword?

    Directory of Open Access Journals (Sweden)

    Jeffrey Wang

    2018-05-01

    Full Text Available Vascular calcification (VC as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification. Therefore, more complex underlying processes involving physiochemical changes to mineral balance, vascular remodelling and perturbed hormonal responses such as parathyroid hormone (PTH and fibroblast growth factor 23 (FGF-23 are likely to contribute to VC. In particular, VC resulting from modifications to calcium, phosphate and vitamin D homeostasis has been recently elucidated. Notably, deregulation of vitamin D metabolism, dietary calcium intake and renal mineral handling are associated with imbalances in systemic calcium and phosphate levels and endothelial cell dysfunction, which can modulate both bone and soft tissue calcification. This review addresses the current understanding of VC pathophysiology, with a focus on the pathogenic role of vitamin D that has provided new insights into the mechanisms of VC.

  3. China’s Exchange Rate Policy: A Double Edged Sword

    Science.gov (United States)

    2013-12-01

    market.10 These four characteristics allowed the East Asian countries of Japan, Taiwan , and South Korea to develop at exponential rates for decades. This...EXCHANGE RATE POLICY Chapter II provides background on important factors affecting China’s exchange rate policy, as well as an overview of its...include telecommunications, tourism , hospitality, 51 World’s Richest Countries, “Top Ten Chinese

  4. Autophagy: A double-edged sword in Alzheimer's disease

    Indian Academy of Sciences (India)

    Laboratory of Molecular Neurobiology, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan; Institute of Zoology, National Taiwan University, Taipei 10617, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan; Department of Surgery, National Taiwan University ...

  5. Fluid Therapy: Double-Edged Sword during Critical Care?

    Science.gov (United States)

    Benes, Jan; Kirov, Mikhail; Kuzkov, Vsevolod; Lainscak, Mitja; Molnar, Zsolt; Voga, Gorazd; Monnet, Xavier

    2015-01-01

    Fluid therapy is still the mainstay of acute care in patients with shock or cardiovascular compromise. However, our understanding of the critically ill pathophysiology has evolved significantly in recent years. The revelation of the glycocalyx layer and subsequent research has redefined the basics of fluids behavior in the circulation. Using less invasive hemodynamic monitoring tools enables us to assess the cardiovascular function in a dynamic perspective. This allows pinpointing even distinct changes induced by treatment, by postural changes, or by interorgan interactions in real time and enables individualized patient management. Regarding fluids as drugs of any other kind led to the need for precise indication, way of administration, and also assessment of side effects. We possess now the evidence that patient centered outcomes may be altered when incorrect time, dose, or type of fluids are administered. In this review, three major features of fluid therapy are discussed: the prediction of fluid responsiveness, potential harms induced by overzealous fluid administration, and finally the problem of protocol-led treatments and their timing.

  6. The Double-Edged Sword of Legitimacy in Public Relations

    DEFF Research Database (Denmark)

    Merkelsen, Henrik

    2011-01-01

    Purpose – This paper seeks to clarify the various aspects of legitimacy in public relations in order to establish a better understanding of the limits of professionalization. Legitimacy has always been a central concept in public relations. In order to ensure a license to operate, the conduct...... of organizations needs to be perceived as legitimate by their stakeholders and the public in general. Public relations has since its conception as a modern profession been confronted with several issues concerning the profession's own legitimacy. The overall cause for these legitimacy problems is often ascribed...... to the immaturity of the profession and professionalization is generally regarded as an appropriate cure. Design/methodology/approach – Through theorization of the connection between legitimacy, power and professionalization the paper points to two important challenges to the professionalization of public relations...

  7. Autophagy: A double-edged sword in Alzheimer's disease

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... This article briefly summarizes seminal discoveries that are shedding new light on the critical and unique roles of autophagy in AD and potential therapeutic ... those of the staff, the journals, various programmes, and Current Science, has changed from 'ias.ernet.in' (or 'academy.ias.ernet.in') to 'ias.ac.in'.

  8. Double-Edged Sword: Social Media Use in the Classroom

    Science.gov (United States)

    Chromey, Kelli J.; Duchsherer, Amy; Pruett, Jennifer; Vareberg, Kyle

    2016-01-01

    The purpose of this research is to identify the students' perceptions of social media use in a classroom setting. Knowing students' perceptions of social media can help the instructor build a course that both student and teacher can find effective. Using focus groups this study found a model to determine if social media is an appropriate or…

  9. Slim edges in double-sided silicon 3D detectors

    International Nuclear Information System (INIS)

    Povoli, M; Dalla Betta, G-F; Bagolini, A; Boscardin, M; Giacomini, G; Vianello, E; Zorzi, N

    2012-01-01

    Minimization of the insensitive edge area is one of the key requirements for silicon radiation detectors to be used in future silicon trackers. In 3D detectors this goal can be achieved with the active edge, at the expense of a high fabrication process complexity. In the framework of the ATLAS 3D sensor collaboration, we produced modified 3D silicon sensors with a double-sided technology. While this approach is not suitable to obtain active edges, because it does not use a support wafer, it allows for a new type of edge termination, the slim edge. In this paper we report on the development of the slim edge, from numerical simulations to design and testing, proving that it works effectively without increasing the fabrication complexity of silicon 3D detectors, and that it could be further optimized to reduce the insensitive edge region to less than 100 μm.

  10. The Double-Edged Sword Effects of Mechanisms Disconnecting Cash-Flow Rights From Voting Rights

    DEFF Research Database (Denmark)

    Fattoum, Asma; Guedri, Zied

    On the one hand, defensive mechanisms such as dual class shares, pyramid structures and pact agreements may produce positive effects on firm performance because they enable CEOs to make long-term and risky investments without being worried by short-term market forces and risk-averse shareholders....

  11. The double-edged sword of pedagogy: Instruction limits spontaneous exploration and discovery.

    Science.gov (United States)

    Bonawitz, Elizabeth; Shafto, Patrick; Gweon, Hyowon; Goodman, Noah D; Spelke, Elizabeth; Schulz, Laura

    2011-09-01

    Motivated by computational analyses, we look at how teaching affects exploration and discovery. In Experiment 1, we investigated children's exploratory play after an adult pedagogically demonstrated a function of a toy, after an interrupted pedagogical demonstration, after a naïve adult demonstrated the function, and at baseline. Preschoolers in the pedagogical condition focused almost exclusively on the target function; by contrast, children in the other conditions explored broadly. In Experiment 2, we show that children restrict their exploration both after direct instruction to themselves and after overhearing direct instruction given to another child; they do not show this constraint after observing direct instruction given to an adult or after observing a non-pedagogical intentional action. We discuss these findings as the result of rational inductive biases. In pedagogical contexts, a teacher's failure to provide evidence for additional functions provides evidence for their absence; such contexts generalize from child to child (because children are likely to have comparable states of knowledge) but not from adult to child. Thus, pedagogy promotes efficient learning but at a cost: children are less likely to perform potentially irrelevant actions but also less likely to discover novel information. Copyright © 2010. Published by Elsevier B.V.

  12. Protease activated receptor 2 in diabetic nephropathy: a double edged sword

    NARCIS (Netherlands)

    Waasdorp, Maaike; Duitman, Janwillem; Florquin, Sandrine; Spek, Arnold C.

    2017-01-01

    Diabetic nephropathy is a major microvascular complication of diabetes mellitus, and the leading cause of end stage renal disease worldwide. The pathogenesis of diabetic nephropathy is complex, making the development of novel treatments that stop or reverse the progression of microalbuminuria into

  13. The Double-edged Sword of Pedagogy: Instruction limits spontaneous exploration and discovery

    Science.gov (United States)

    Shafto, Patrick; Gweon, Hyowon; Goodman, Noah D.; Spelke, Elizabeth; Schulz, Laura

    2012-01-01

    Motivated by computational analyses, we look at how teaching affects exploration and discovery. In Experiment 1, we investigated children’s exploratory play after an adult pedagogically demonstrated a function of a toy, after an interrupted pedagogical demonstration, after a naïve adult demonstrated the function, and at baseline. Preschoolers in the pedagogical condition focused almost exclusively on the target function; by contrast, children in the other conditions explored broadly. In Experiment 2, we show that children restrict their exploration both after direct instruction to themselves and after overhearing direct instruction given to another child; they do not show this constraint after observing direct instruction given to an adult or after observing a non-pedagogical intentional action. We discuss these findings as the result of rational inductive biases. In pedagogical contexts, a teacher’s failure to provide evidence for additional functions provides evidence for their absence; such contexts generalize from child to child (because children are likely to have comparable states of knowledge) but not from adult to child. Thus, pedagogy promotes efficient learning but at a cost: children are less likely to perform potentially irrelevant actions but also less likely to discover novel information. PMID:21216395

  14. Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

    Directory of Open Access Journals (Sweden)

    Asha Acharya

    2010-01-01

    Full Text Available Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of reactive oxygen species (ROS and cell’s own antioxidant defenses. ROS deregulate the redox homeostasis and promote tumor formation by initiating an aberrant induction of signaling networks that cause tumorigenesis. Ultraviolet (UV exposures, γ-radiation and other environmental carcinogens generate ROS in the cells, which can exert apoptosis in the tumors, thereby killing the malignant cells or induce the progression of the cancer growth by blocking cellular defense system. Cancer stem cells take the advantage of the aberrant redox system and spontaneously proliferate. Oxidative stress and gene-environment interactions play a significant role in the development of breast, prostate, pancreatic and colon cancer. Prolonged lifetime exposure to estrogen is associated with several kinds of DNA damage. Oxidative stress and estrogen receptor-associated proliferative changes are suggested to play important roles in estrogen-induced breast carcinogenesis. BRCA1, a tumor suppressor against hormone responsive cancers such as breast and prostate cancer, plays a significant role in inhibiting ROS and estrogen mediated DNA damage; thereby regulate the redox homeostasis of the cells. Several transcription factors and tumor suppressors are involved during stress response such as Nrf2, NFκB and BRCA1. A promising strategy for targeting redox status of the cells is to use readily available natural substances from vegetables, fruits, herbs and spices. Many of the phytochemicals have already been identified to have chemopreventive potential, capable of intervening in carcinogenesis.

  15. International countertrade arrangements and their legal structure: Double edge sword or future of the modern trade

    Directory of Open Access Journals (Sweden)

    Milenković-Kerković Tamara

    2011-01-01

    Full Text Available The experiences and the practice of many countries show that countertrade could be used as the significant method for incensement of the export as well as for the promotion of the foreign investments even in the period of deep financial crises. Contemporary governments' pro-active countertrade orientation in USA, Israel, Sweden, Norway, Japan and other developed countries highlights the inadequacy of the obsolete and stereotypical concept of the countertrade as the compensation transaction based on the 'trade without money' concept. Besides this, the practices proved that countertrade transactions are the consequence and the indicator of economic shocks. Therefore, the study of the special legal issues that may arise in countertrade transactions will be very important not only for the domestic legal doctrine but also for the commercial practice. As national laws do not contain provisions specific for countertrade, it is of particular importance to analyze legal question such as structuring and drafting of countertrade arrangements as well as to study the question of the legal nature of the contractual link between legal instruments which form multicontractual mechanism of countertrade transactions. The character of the legal connection among the legal instruments in countertrade arrangement, as well as the legal nature of the countertrade commitment, strongly influence the countertrade agreement's legal nature. The economic reality of a group of contracts joined by the common goal of the transaction (consideration and the countertrade commitment has to be followed by the legal reality which will recognize the legal interdependence of the obligation deriving from the legally independent countertrade arrangement.

  16. International countertrade arrangements and their legal structure: Double edge sword or future of the modern trade

    OpenAIRE

    Milenković-Kerković Tamara

    2011-01-01

    The experiences and the practice of many countries show that countertrade could be used as the significant method for incensement of the export as well as for the promotion of the foreign investments even in the period of deep financial crises. Contemporary governments' pro-active countertrade orientation in USA, Israel, Sweden, Norway, Japan and other developed countries highlights the inadequacy of the obsolete and stereotypical concept of the countertrade as the compensation transaction ba...

  17. Radiological surveillance in multiple endocrine neoplasia type 1: a double-edged sword?

    Directory of Open Access Journals (Sweden)

    Ruth Therese Casey

    2017-03-01

    Full Text Available Context: Multiple endocrine neoplasia type 1 (MEN1 is a hereditary condition characterised by the predisposition to hyperplasia/tumours of endocrine glands. MEN1-related disease, moreover, malignancy related to MEN1, is increasingly responsible for death in up to two-thirds of patients. Although patients undergo radiological and biochemical surveillance, current recommendations for radiological monitoring are based on non-prospective data with little consensus or evidence demonstrating improved outcome from this approach. Here, we sought to determine whether cumulative radiation exposure as part of the recommended radiological screening programme posed a distinct risk in a cohort of patients with MEN1.Patients and study design: A retrospective review of 43 patients with MEN1 attending our institution between 2007 and 2015 was performed. Demographic and clinical information including phenotype was obtained for all patients. We also obtained details regarding all radiological procedures performed as part of MEN1 surveillance or disease localisation. An estimated effective radiation dose (ED for each individual patient was calculated.Results: The mean ED for the total patient cohort was 121 mSv, and the estimated mean lifetime risk of cancer secondary to radiation exposure was 0.49%. Patients with malignant neuroendocrine tumours (NETS had significantly higher ED levels compared to patients without metastatic disease (P < 0.0022.Conclusions: In MEN1, radiological surveillance is associated with clinically significant exposure to ionising radiation. In patients with MEN1, multi-modality imaging strategies designed to minimise this exposure should be considered.

  18. The double-edged sword of electronic health records: implications for patient disclosure.

    Science.gov (United States)

    Campos-Castillo, Celeste; Anthony, Denise L

    2015-04-01

    Electronic health record (EHR) systems are linked to improvements in quality of care, yet also privacy and security risks. Results from research studies are mixed about whether patients withhold personal information from their providers to protect against the perceived EHR privacy and security risks. This study seeks to reconcile the mixed findings by focusing on whether accounting for patients' global ratings of care reveals a relationship between EHR provider-use and patient non-disclosure. A nationally representative sample from the 2012 Health Information National Trends Survey was analyzed using bivariate and multivariable logit regressions to examine whether global ratings of care suppress the relationship between EHR provider-use and patient non-disclosure. 13% of respondents reported having ever withheld information from a provider because of privacy/security concerns. Bivariate analysis showed that withholding information was unrelated to whether respondents' providers used an EHR. Multivariable analysis showed that accounting for respondents' global ratings of care revealed a positive relationship between having a provider who uses an EHR and withholding information. After accounting for global ratings of care, findings suggest that patients may non-disclose to providers to protect against the perceived EHR privacy and security risks. Despite evidence that EHRs inhibit patient disclosure, their advantages for promoting quality of care may outweigh the drawbacks. Clinicians should leverage the EHR's value in quality of care and discuss patients' privacy concerns during clinic visits, while policy makers should consider how to address the real and perceived privacy and security risks of EHRs. © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. A double-edged sword!: The Dutch centre-right and the 'foreigners issue'

    NARCIS (Netherlands)

    van Kersbergen, C.J.; Krouwel, A.P.M.

    2008-01-01

    We study the impact of the 'foreigners issue' on centre-right politics in the Netherlands. This issue concerns a complex of problems related to migration, asylum-seekers, nationalism, multiculturalism and European integration. The Dutch centre-right has moved towards hard-line and restrictive

  20. IFNγ-producing CD4+ T lymphocytes: the double-edged swords in tuberculosis.

    Science.gov (United States)

    Kumar, Pawan

    2017-12-01

    IFNγ-producing CD4 + T cells (IFNγ + CD4 + T cells) are the key orchestrators of protective immunity against Mycobacterium tuberculosis (Mtb). Primarily, these cells act by enabling Mtb-infected macrophages to enforce phagosome-lysosome fusion, produce reactive nitrogen intermediates (RNIs), and activate autophagy pathways. However, TB is a heterogeneous disease and a host of clinical and experimental findings has also implicated IFNγ + CD4 + T cells in TB pathogenesis. High frequency of IFNγ + CD4 + T cells is the most invariable feature of the active disease. Active TB patients mount a heightened IFNγ + CD4 + T cell response to mycobacterial antigens and demonstrate an IFNγ-inducible transcriptomic signature. IFNγ + CD4 + T cells have also been shown to mediate TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) observed in a subset of antiretroviral therapy (ART)-treated HIV- and Mtb-coinfected people. The pathological face of IFNγ + CD4 + T cells during mycobacterial infection is further uncovered by studies in the animal model of TB-IRIS and in Mtb-infected PD-1 -/- mice. This manuscript encompasses the evidence supporting the dual role of IFNγ + CD4 + T cells during Mtb infection and sheds light on immune mechanisms involved in protection versus pathogenesis.

  1. Autophagy and its effects: making sense of double-edged swords.

    Science.gov (United States)

    Thorburn, Andrew

    2014-10-01

    Autophagy is the mechanism by which cellular material is delivered to lysosomes and degraded. This process has become a major focus of biological and biomedical research with thousands of papers published each year and rapidly growing appreciation that autophagy affects many normal and pathological processes. However, as we learn more about this evolutionarily ancient process, we are discovering that autophagy's effects may work for both the good and the bad of an organism. Here, I discuss some of these context-dependent findings and how, as we make sense of them, we can try to apply our knowledge for practical purposes.

  2. Hydrogen peroxide and polyamines act as double edged swords in plant abiotic stress responses

    Directory of Open Access Journals (Sweden)

    Kamala Gupta

    2016-09-01

    Full Text Available The specific genetic changes through which plants adapt to the multitude of environmental stresses are possible because of the molecular regulations in the system. These intricate regulatory mechanisms once unveiled will surely raise interesting questions. Polyamines and hydrogen peroxide have been suggested to be important signalling molecules during biotic and abiotic stresses. Hydrogen peroxide plays a versatile role from orchestrating physiological processes to stress response. It helps to achieve acclimatization and tolerance to stress by coordinating intra-cellular and systemic signalling systems. Polyamines, on the other hand, are low molecular weight polycationic aliphatic amines, which have been implicated in various stress responses. It is quite interesting to note that both hydrogen peroxide and polyamines have a fine line of inter-relation between them since the catabolic pathways of the latter releases hydrogen peroxide. In this review we have tried to illustrate the roles and their multifaceted functions of these two important signalling molecules based on current literature. This review also highlights the fact that over accumulation of hydrogen peroxide and polyamines can be detrimental for plant cells leading to toxicity and pre-mature cell death.

  3. Temperate bacterial viruses as double-edged swords in bacterial warfare.

    Science.gov (United States)

    Gama, João Alves; Reis, Ana Maria; Domingues, Iolanda; Mendes-Soares, Helena; Matos, Ana Margarida; Dionisio, Francisco

    2013-01-01

    It has been argued that bacterial cells may use their temperate viruses as biological weapons. For instance, a few bacterial cells among a population of lysogenic cells could release the virus and kill susceptible non-lysogenic competitors, while their clone mates would be immune. Because viruses replicate inside their victims upon infection, this process would amplify their number in the arena. Sometimes, however, temperate viruses spare recipient cells from death by establishing themselves in a dormant state inside cells. This phenomenon is called lysogenization and, for some viruses such as the λ virus, the probability of lysogenization increases with the multiplicity of infection. Therefore, the amplification of viruses leads to conflicting predictions about the efficacy of temperate viruses as biological weapons: amplification can increase the relative advantage of clone mates of lysogens but also the likelihood of saving susceptible cells from death, because the probability of lysogenization is higher. To test the usefulness of viruses as biological weapons, we performed competition experiments between lysogenic Escherichia coli cells carrying the λ virus and susceptible λ-free E. coli cells, either in a structured or unstructured habitat. In structured and sometimes in unstructured habitats, the λ virus qualitatively behaved as a "replicating toxin". However, such toxic effect of λ viruses ceased after a few days of competition. This was due to the fact that many of initially susceptible cells became lysogenic. Massive lysogenization of susceptible cells occurred precisely under the conditions where the amplification of the virus was substantial. From then on, these cells and their descendants became immune to the λ virus. In conclusion, if at short term bacterial cells may use temperate viruses as biological weapons, after a few days only the classical view of temperate bacterial viruses as parasitic agents prevails.

  4. Filamentous phages of Ralstonia solanacearum: double-edged swords for pathogenic bacteria.

    Science.gov (United States)

    Yamada, Takashi

    2013-01-01

    Some phages from genus Inovirus use host or bacteriophage-encoded site-specific integrases or recombinases establish a prophage state. During integration or excision, a superinfective form can be produced. The three states (free, prophage, and superinfective) of such phages exert different effects on host bacterial phenotypes. In Ralstonia solanacearum, the causative agent of bacterial wilt disease of crops, the bacterial virulence can be positively or negatively affected by filamentous phages, depending on their state. The presence or absence of a repressor gene in the phage genome may be responsible for the host phenotypic differences (virulent or avirulent) caused by phage infection. This strategy of virulence control may be widespread among filamentous phages that infect pathogenic bacteria of plants.

  5. Hydrogen Peroxide and Polyamines Act as Double Edged Swords in Plant Abiotic Stress Responses.

    Science.gov (United States)

    Gupta, Kamala; Sengupta, Atreyee; Chakraborty, Mayukh; Gupta, Bhaskar

    2016-01-01

    The specific genetic changes through which plants adapt to the multitude of environmental stresses are possible because of the molecular regulations in the system. These intricate regulatory mechanisms once unveiled will surely raise interesting questions. Polyamines and hydrogen peroxide have been suggested to be important signaling molecules during biotic and abiotic stresses. Hydrogen peroxide plays a versatile role from orchestrating physiological processes to stress response. It helps to achieve acclimatization and tolerance to stress by coordinating intra-cellular and systemic signaling systems. Polyamines, on the other hand, are low molecular weight polycationic aliphatic amines, which have been implicated in various stress responses. It is quite interesting to note that both hydrogen peroxide and polyamines have a fine line of inter-relation between them since the catabolic pathways of the latter releases hydrogen peroxide. In this review we have tried to illustrate the roles and their multifaceted functions of these two important signaling molecules based on current literature. This review also highlights the fact that over accumulation of hydrogen peroxide and polyamines can be detrimental for plant cells leading to toxicity and pre-mature cell death.

  6. Teaching Mathematics by Comparison: Analog Visibility as a Double-Edged Sword

    Science.gov (United States)

    Begolli, Kreshnik Nasi; Richland, Lindsey Engle

    2016-01-01

    Comparing multiple solutions to a single problem is an important mode for developing flexible mathematical thinking, yet instructionally leading this activity is challenging (Stein, Engle, Smith, & Hughes, 2008). We test 1 decision teachers must make after having students solve a problem: whether to only verbally discuss students' solutions or…

  7. "My Past Is a Double Edge Sword": Temporality and Reflexivity in Mature Learners

    Science.gov (United States)

    Stevenson, Jacqueline; Clegg, Sue

    2013-01-01

    This paper discusses the ways in which mature students orientate themselves towards the future in making decisions to access higher education (HE). Their narratives connect their past, often difficult, educational and personal lives to their future aspirations and to their current experiences in further education (FE) and HE. The research was part…

  8. The Double-Edged Sword of Pedagogy: Instruction Limits Spontaneous Exploration and Discovery

    Science.gov (United States)

    Bonawitz, Elizabeth; Shafto, Patrick; Gweon, Hyowon; Goodman, Noah D.; Spelke, Elizabeth; Schulz, Laura

    2011-01-01

    Motivated by computational analyses, we look at how teaching affects exploration and discovery. In Experiment 1, we investigated children's exploratory play after an adult pedagogically demonstrated a function of a toy, after an interrupted pedagogical demonstration, after a naive adult demonstrated the function, and at baseline. Preschoolers in…

  9. Temperate bacterial viruses as double-edged swords in bacterial warfare.

    Directory of Open Access Journals (Sweden)

    João Alves Gama

    Full Text Available It has been argued that bacterial cells may use their temperate viruses as biological weapons. For instance, a few bacterial cells among a population of lysogenic cells could release the virus and kill susceptible non-lysogenic competitors, while their clone mates would be immune. Because viruses replicate inside their victims upon infection, this process would amplify their number in the arena. Sometimes, however, temperate viruses spare recipient cells from death by establishing themselves in a dormant state inside cells. This phenomenon is called lysogenization and, for some viruses such as the λ virus, the probability of lysogenization increases with the multiplicity of infection. Therefore, the amplification of viruses leads to conflicting predictions about the efficacy of temperate viruses as biological weapons: amplification can increase the relative advantage of clone mates of lysogens but also the likelihood of saving susceptible cells from death, because the probability of lysogenization is higher. To test the usefulness of viruses as biological weapons, we performed competition experiments between lysogenic Escherichia coli cells carrying the λ virus and susceptible λ-free E. coli cells, either in a structured or unstructured habitat. In structured and sometimes in unstructured habitats, the λ virus qualitatively behaved as a "replicating toxin". However, such toxic effect of λ viruses ceased after a few days of competition. This was due to the fact that many of initially susceptible cells became lysogenic. Massive lysogenization of susceptible cells occurred precisely under the conditions where the amplification of the virus was substantial. From then on, these cells and their descendants became immune to the λ virus. In conclusion, if at short term bacterial cells may use temperate viruses as biological weapons, after a few days only the classical view of temperate bacterial viruses as parasitic agents prevails.

  10. A double-edged sword: Benefits and pitfalls of heterogeneous punishment in evolutionary inspection games

    Science.gov (United States)

    Perc, Matjaž; Szolnoki, Attila

    2015-06-01

    As a simple model for criminal behavior, the traditional two-strategy inspection game yields counterintuitive results that fail to describe empirical data. The latter shows that crime is often recurrent, and that crime rates do not respond linearly to mitigation attempts. A more apt model entails ordinary people who neither commit nor sanction crime as the third strategy besides the criminals and punishers. Since ordinary people free-ride on the sanctioning efforts of punishers, they may introduce cyclic dominance that enables the coexistence of all three competing strategies. In this setup ordinary individuals become the biggest impediment to crime abatement. We therefore also consider heterogeneous punisher strategies, which seek to reduce their investment into fighting crime in order to attain a more competitive payoff. We show that this diversity of punishment leads to an explosion of complexity in the system, where the benefits and pitfalls of criminal behavior are revealed in the most unexpected ways. Due to the raise and fall of different alliances no less than six consecutive phase transitions occur in dependence on solely the temptation to succumb to criminal behavior, leading the population from ordinary people-dominated across punisher-dominated to crime-dominated phases, yet always failing to abolish crime completely.

  11. Education Policy Reform in Sri Lanka: The Double-Edged Sword of Political Will

    Science.gov (United States)

    Little, Angela W.

    2011-01-01

    In 1997, the Government of Sri Lanka launched a comprehensive set of education reforms designed to promote equitable access to basic education and improvements in learning outcomes. The package of reforms arose as a political response to widespread youth unrest in the late 1980s and attracted considerable "political will", a vague but…

  12. Autophagy and its effects: making sense of double-edged swords.

    Directory of Open Access Journals (Sweden)

    Andrew Thorburn

    2014-10-01

    Full Text Available Autophagy is the mechanism by which cellular material is delivered to lysosomes and degraded. This process has become a major focus of biological and biomedical research with thousands of papers published each year and rapidly growing appreciation that autophagy affects many normal and pathological processes. However, as we learn more about this evolutionarily ancient process, we are discovering that autophagy's effects may work for both the good and the bad of an organism. Here, I discuss some of these context-dependent findings and how, as we make sense of them, we can try to apply our knowledge for practical purposes.

  13. Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword

    Directory of Open Access Journals (Sweden)

    Howard Li

    2012-01-01

    Full Text Available Peroxisome proliferator-activated receptor-γ (PPARγ is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiological processes, including cancer. Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione class of antidiabetic drugs. Activation of PPARγ in a variety of cancer cells leads to inhibition of growth, decreased invasiveness, reduced production of proinflammatory cytokines, and promotion of a more differentiated phenotype. However, systemic activation of PPARγ has been reported to be protumorigenic in some in vitro systems and in vivo models. Here, we review the available data that implicate PPARγ in lung carcinogenesis and highlight the challenges of targeting PPARγ in lung cancer treatments.

  14. Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?

    Science.gov (United States)

    Calabresi, Paolo; Ghiglieri, Veronica; Mazzocchetti, Petra; Corbelli, Ilenia; Picconi, Barbara

    2015-01-01

    The long-term replacement therapy with the dopamine (DA) precursor 3,4-dihydroxy-l-phenylalanine (L-DOPA) is a milestone in the treatment of Parkinson's disease (PD). Although this drug precursor can be metabolized into the active neurotransmitter DA throughout the brain, its therapeutic benefit is due to restoring extracellular DA levels within the dorsal striatum, which lacks endogenous DA as a consequence of the neurodegenerative process induced by the disease. In the early phases of PD, L-DOPA treatment is able to restore both long-term depression (LTD) and long-term potentiation (LTP), two major forms of corticostriatal synaptic plasticity that are altered by dopaminergic denervation. However, unlike physiological DA transmission, this therapeutic approach in the advanced phase of the disease leads to abnormal peaks of DA, non-synaptically released, which are supposed to trigger behavioural sensitization, namely L-DOPA-induced dyskinesia. This condition is characterized by a loss of synaptic depotentiation, an inability to reverse previously induced LTP. In the advanced stages of PD, L-DOPA can also induce non-motor fluctuations with cognitive dysfunction and neuropsychiatric symptoms such as compulsive behaviours and impulse control disorders. Although the mechanisms underlying the role of L-DOPA in both motor and behavioural symptoms are still incompletely understood, recent data from electrophysiological and imaging studies have increased our understanding of the function of the brain areas involved and of the mechanisms implicated in both therapeutic and adverse actions of L-DOPA in PD patients. PMID:26009763

  15. Ibrutinib-A double-edge sword in cancer and autoimmune disorders

    OpenAIRE

    Kokhaei, Parviz; Jadidi-Niaragh, Farhad; Sotoodeh Jahromi, Abdolreza; Österborg, Anders; Mellstedt, Håkan; Hojjat-Farsangi, Mohammad

    2015-01-01

    Targeted therapies have appeared as new treatment options for several disease types, including cancer and autoimmune disorders. Of several targets, tyrosine kinases (TKs) are among the most promising. Overexpression of TKs provides a target for novel therapeutic agents, including small molecule inhibitors of tyrosine kinases (TKI). Ibrutinib (PCI-32765) is a TKI of Bruton’s tyrosine kinase (Btk), a key kinase of the B-cell receptor signaling pathway that plays a significant role in the prolif...

  16. Ibrutinib-A double-edge sword in cancer and autoimmune disorders.

    Science.gov (United States)

    Kokhaei, Parviz; Jadidi-Niaragh, Farhad; Sotoodeh Jahromi, Abdolreza; Osterborg, Anders; Mellstedt, Håkan; Hojjat-Farsangi, Mohammad

    2016-01-01

    Targeted therapies have appeared as new treatment options for several disease types, including cancer and autoimmune disorders. Of several targets, tyrosine kinases (TKs) are among the most promising. Overexpression of TKs provides a target for novel therapeutic agents, including small molecule inhibitors of tyrosine kinases (TKI). Ibrutinib (PCI-32765) is a TKI of Bruton's tyrosine kinase (Btk), a key kinase of the B-cell receptor signaling pathway that plays a significant role in the proliferation, differentiation and survival of B cells. In addition to inhibitory effects, recent studies have shown that ibrutinib has multiple immunomodulatory effects. It binds covalently to IL-2 inducible tyrosine kinase (Itk) in T lymphocytes and suppresses the survival of T-helper (Th) 2 cells. This changes the balance of Th1/Th2 cells toward Th1 subset, which are the main immune cells targeting tumor cells. The dual activity of ibrutinib has paid a great attention and several studies are evaluating the anti-tumor and immunomodulatory effects in cancer, autoimmune disorders and infectious diseases. In this article we review the inhibitory and immunomodulatory effects of ibrutinib in B-cell malignancies, autoimmune diseases and infections, as well as the communication between the Ror1 receptor tyrosine kinase and BCR and effects of ibrutinib on this crosstalk.

  17. Oligomeric coiled-coil adhesin YadA is a double-edged sword.

    Directory of Open Access Journals (Sweden)

    Salome Casutt-Meyer

    Full Text Available Yersinia adhesin A (YadA is an essential virulence factor for the food-borne pathogens Yersinia enterocolitica and Yersinia pseudotuberculosis. Surprisingly, it is a pseudogene in Yersinia pestis. Even more intriguing, the introduction of a functional yadA gene in Y. pestis EV76 was shown to correlate with a decrease in virulence in a mouse model. Here, we report that wild type (wt Y. enterocolitica E40, as well as YadA-deprived E40 induced the synthesis of neutrophil extracellular traps (NETs upon contact with neutrophils, but only YadA-expressing Y. enterocolitica adhered to NETs and were killed. As binding seemed to be a prerequisite for killing, we searched for YadA-binding substrates and detected the presence of collagen within NETs. E40 bacteria expressing V98D,N99A mutant YadA with a severely reduced ability to bind collagen were found to be more resistant to killing, suggesting that collagen binding contributes significantly to sensitivity to NETs. Wt Y. pestis EV76 were resistant to killing by NETs, while recombinant EV76 expressing YadA from either Y. pseudotuberculosis or Y. enterocolitica were sensitive to killing by NETs, outlining the importance of YadA for susceptibility to NET-dependent killing. Recombinant EV76 endowed with YadA from Y. enterocolitica were also less virulent for the mouse than wt EV76, as shown before. In addition, EV76 carrying wt YadA were less virulent for the mouse than EV76 expressing YadA(V₉₈D,N₉₉A. The observation that YadA makes Yersinia sensitive to NETs provides an explanation as for why evolution selected for the inactivation of yadA in the flea-borne Y. pestis and clarifies an old enigma. Since YadA imposes the same cost to the food-borne Yersinia but was nevertheless conserved by evolution, this observation also illustrates the duality of some virulence functions.

  18. Elevated catalase expression in a fungal pathogen is a double-edged sword of iron.

    Directory of Open Access Journals (Sweden)

    Arnab Pradhan

    2017-05-01

    Full Text Available Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen species (ROS is an essential component of these responses. We showed previously that ectopic expression of the heme-containing catalase enzyme in Candida albicans enhances resistance to oxidative stress, combinatorial oxidative plus cationic stress, and phagocytic killing. Clearly ectopic catalase expression confers fitness advantages in the presence of stress, and therefore in this study we tested whether it enhances fitness in the absence of stress. We addressed this using a set of congenic barcoded C. albicans strains that include doxycycline-conditional tetON-CAT1 expressors. We show that high basal catalase levels, rather than CAT1 induction following stress imposition, reduce ROS accumulation and cell death, thereby promoting resistance to acute peroxide or combinatorial stress. This conclusion is reinforced by our analyses of phenotypically diverse clinical isolates and the impact of stochastic variation in catalase expression upon stress resistance in genetically homogeneous C. albicans populations. Accordingly, cat1Δ cells are more sensitive to neutrophil killing. However, we find that catalase inactivation does not attenuate C. albicans virulence in mouse or invertebrate models of systemic candidiasis. Furthermore, our direct comparisons of fitness in vitro using isogenic barcoded CAT1, cat1Δ and tetON-CAT1 strains show that, while ectopic catalase expression confers a fitness advantage during peroxide stress, it confers a fitness defect in the absence of stress. This fitness defect is suppressed by iron supplementation. Also high basal catalase levels induce key iron assimilatory functions (CFL5, FET3, FRP1, FTR1. We conclude that while high basal catalase levels enhance peroxide stress resistance, they place pressure on iron homeostasis through an elevated cellular demand for iron, thereby reducing the fitness of C. albicans in iron-limiting tissues within the host.

  19. Smoking and stress: the double-edged sword of living in a disadvantaged area

    Directory of Open Access Journals (Sweden)

    Dr George Tsourtos

    2008-01-01

    Full Text Available Background: Primary care-based smoking cessation interventions are often less effective amonglow-SES groups. Higher stress levels may explain the lower quit rate and higher prevalence ofsmoking in low-SES groups, and why the relative smoking prevalence rate is not declining at anequitable rate (same prevalence rate as higher SES groups. To understand these issues, thispaper sought answers to two questions: is stress perceived by ex-smokers and current smokers asa barrier to quitting; and does stress act as a barrier to quitting in relation to other barriers indisadvantaged areas?Methods: This paper seeks to understand the lived experiences from participants in 2 focusgroups and 11 in-depth interviews, who reside in the most disadvantaged area in metropolitanAdelaide, regarding stress as a barrier to smoking cessation.Results: The data pointed to stress as an ever-present aspect of life for people in low-SES areasfor many reasons, most stemming from the social environment. Perceived stress was also foundto be a major barrier to smoking cessation, more so for current smokers.Conclusions: The data analysis revealed that people in low-SES areas maybe living inenvironments with increased levels of perceived stress, making them more likely to start, andless likely to quit, smoking. It is argued that the “middle-ground” be taken in a structure-agencyapproach regarding smoking cessation, recognising the potential of social systems to create stresswhilst also recognising that individuals have the capacity to change aspects of their lives (e.g. toquit smoking. Without the awareness of such an approach, primary care efforts at smokingcessation may only serve to increase current inequities in smoking prevalence rates.

  20. Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer.

    Science.gov (United States)

    Marelli, Giulia; Howells, Anwen; Lemoine, Nicholas R; Wang, Yaohe

    2018-01-01

    Oncolytic viral therapy is a new promising strategy against cancer. Oncolytic viruses (OVs) can replicate in cancer cells but not in normal cells, leading to lysis of the tumor mass. Beside this primary effect, OVs can also stimulate the immune system. Tumors are an immuno-suppressive environment in which the immune system is silenced in order to avoid the immune response against cancer cells. The delivery of OVs into the tumor wakes up the immune system so that it can facilitate a strong and durable response against the tumor itself. Both innate and adaptive immune responses contribute to this process, producing an immune response against tumor antigens and facilitating immunological memory. However, viruses are recognized by the immune system as pathogens and the consequent anti-viral response could represent a big hurdle for OVs. Finding a balance between anti-tumor and anti-viral immunity is, under this new light, a priority for researchers. In this review, we provide an overview of the various ways in which different components of the immune system can be allied with OVs. We have analyzed the different immune responses in order to highlight the new and promising perspectives leading to increased anti-tumor response and decreased immune reaction to the OVs.

  1. Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?

    Directory of Open Access Journals (Sweden)

    Daniele Fanale

    2015-01-01

    Full Text Available Microtubules are dynamic and structural cellular components involved in several cell functions, including cell shape, motility, and intracellular trafficking. In proliferating cells, they are essential components in the division process through the formation of the mitotic spindle. As a result of these functions, tubulin and microtubules are targets for anticancer agents. Microtubule-targeting agents can be divided into two groups: microtubule-stabilizing, and microtubule-destabilizing agents. The former bind to the tubulin polymer and stabilize microtubules, while the latter bind to the tubulin dimers and destabilize microtubules. Alteration of tubulin-microtubule equilibrium determines the disruption of the mitotic spindle, halting the cell cycle at the metaphase-anaphase transition and, eventually, resulting in cell death. Clinical application of earlier microtubule inhibitors, however, unfortunately showed several limits, such as neurological and bone marrow toxicity and the emergence of drug-resistant tumor cells. Here we review several natural and synthetic microtubule-targeting agents, which showed antitumor activity and increased efficacy in comparison to traditional drugs in various preclinical and clinical studies. Cryptophycins, combretastatins, ombrabulin, soblidotin, D-24851, epothilones and discodermolide were used in clinical trials. Some of them showed antiangiogenic and antivascular activity and others showed the ability to overcome multidrug resistance, supporting their possible use in chemotherapy.

  2. Tubal origin of ovarian cancer - the double-edged sword of haemoglobin.

    Science.gov (United States)

    Lin, Shiou-Fu; Gerry, Emily; Shih, Ie-Ming

    2017-05-01

    Ovarian high-grade serous carcinoma (HGSC) is the most malignant neoplasm of the gynaecological tract. While the origins of many human malignant neoplasms are clear, the origin of HGSC remains poorly understood. This lack of knowledge limits our understanding of its pathogenesis and compromises efforts devoted to developing better early detection tools and effective preventative interventions. The paradigm of the tubal origin of HGSC has been advanced since the initial report of dysplastic lesions (now known as serous tubal intraepithelial carcinomas or STICs) that morphologically resemble HGSC in the Fallopian tube. These were observed in a group of patients with a genetic predisposition to ovarian cancer who were undergoing risk-reducing salpingo-oophorectomy. Since then, a series of clinico-pathological and molecular studies have characterized STICs and their concurrent HGSCs, and the results support the new paradigm of a tubal origin of many 'ovarian' HGSCs. Reactive oxygen species-containing ovulatory follicular fluid has been thought to be the major culprit behind DNA damage in tubal epithelial cells, leading to either cell death or, if the cells survive, mutagenesis. A recent report from this journal demonstrates that ferryl haemoglobin (Hb) in peritoneal fluid could prevent cell death from DNA-damaged fimbrial epithelial cells, facilitating ovulation-induced carcinogenesis of tubal epithelium. This timely study provides new insight into the tumour initiation event in HGSC. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  3. Mitochondrial deficiency: a double-edged sword for ageing and neurodegeneration

    Directory of Open Access Journals (Sweden)

    Daniele eBano

    2012-11-01

    Full Text Available For decades, ageing was considered the inevitable result of the accumulation of damaged macromolecules due to environmental factors and intrinsic processes. Our current knowledge clearly supports that ageing is a complex biological process influenced by multiple evolutionary conserved molecular pathways. With the advanced age, loss of cellular homeostasis severely affects the structure and function of various tissues, especially those highly sensitive to stressful conditions like the central nervous system. In this regard, the age-related regression of neural circuits and the consequent poor neuronal plasticity have been associated with metabolic dysfunctions, in which the decline of mitochondrial activity significantly contributes. Interestingly, while mitochondrial lesions promote the onset of degenerative disorders, mild mitochondrial manipulations delay some of the age-related phenotypes and, more importantly, increase the lifespan of organisms ranging from invertebrates to mammals. Here, we survey the insulin/IGF-1 and the TOR signaling pathways and review how these two important longevity determinants regulate mitochondrial activity. Furthermore, we discuss the contribution of slight mitochondrial dysfunction in the engagement of pro-longevity processes and the opposite role of strong mitochondrial dysfunction in neurodegeneration.

  4. LandCyber Operations: A Double Edged Sword or a Dream Team?

    Science.gov (United States)

    2013-03-01

    reliance on cyberspace for information continues to grow for both the US Army and the world . The US Army must be able to protect itself and exploit...power, economic tension and overpopulation are but a few of the underlying conditions that will foment conflict in the 21st century. History has...capabilities may seem revolutionary but no more than an airplane dropping bombs in World War I or Army amphibious operations in World War II or even

  5. A double-edged sword: Benefits and pitfalls of heterogeneous punishment in evolutionary inspection games.

    Science.gov (United States)

    Perc, Matjaž; Szolnoki, Attila

    2015-06-05

    As a simple model for criminal behavior, the traditional two-strategy inspection game yields counterintuitive results that fail to describe empirical data. The latter shows that crime is often recurrent, and that crime rates do not respond linearly to mitigation attempts. A more apt model entails ordinary people who neither commit nor sanction crime as the third strategy besides the criminals and punishers. Since ordinary people free-ride on the sanctioning efforts of punishers, they may introduce cyclic dominance that enables the coexistence of all three competing strategies. In this setup ordinary individuals become the biggest impediment to crime abatement. We therefore also consider heterogeneous punisher strategies, which seek to reduce their investment into fighting crime in order to attain a more competitive payoff. We show that this diversity of punishment leads to an explosion of complexity in the system, where the benefits and pitfalls of criminal behavior are revealed in the most unexpected ways. Due to the raise and fall of different alliances no less than six consecutive phase transitions occur in dependence on solely the temptation to succumb to criminal behavior, leading the population from ordinary people-dominated across punisher-dominated to crime-dominated phases, yet always failing to abolish crime completely.

  6. Chinese Sex-Role Conceptions: A Double Edged Sword for Women.

    Science.gov (United States)

    Korabik, Karen

    Although Chinese government policies officially support the equality of the sexes, stereotyped views about the nature of men and women often serve to perpetuate discrimination and to keep women in inferior positions. Women are often segregated into lower paying jobs because of stereotypical views about what is natural for women to do. Despite…

  7. The macrophage scavenger receptor (CD163): a double-edged sword in treatment of malignant disease

    DEFF Research Database (Denmark)

    Maniecki, Maciej Bogdan

    2009-01-01

    of inflammatory processes. The receptor is expressed by circulatory monocytes and it is highly expressed on tissue-resident macrophages. CD163 is also expressed on leukemic blast cells of AML type M4/M5 and tumor cells in malignant melanoma and breast cancer. Although circumstantial evidence of the potential...... was investigated in biopsies from bladder cancer patients. We demonstrated that CD163 mRNA expression was significantly elevated in muscle invasive tumors (T2-T4) compared with superficial tumors (Ta), and that a high level of CD163 mRNA expression in tumor biopsies was significantly associated with poor 13-year......The hemoglobin scavenger receptor CD163 is a transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) domain family. It mediates the clearance of hemoglobin released to the circulation during intravascular hemolysis, and it is also involved in the regulation...

  8. Is Co-Branding a Double-Edged Sword for Brand Partners?

    OpenAIRE

    Chia-Lin Lee

    2014-01-01

    Co-branding is a popular business practice, but marketing scholars have paid very limited attention to co-branding success in the horizontal co-branding context. The aim of the current study is therefore to investigate the impact of a good product-fit in terms of attributelevel complementarity on co-branding success. We first define co-branding success, as one of two effects — a synergy effect and a positive spillover effect. Then, assuming attributelevel complementarity exists, we test two h...

  9. Elevated catalase expression in a fungal pathogen is a double-edged sword of iron.

    Science.gov (United States)

    Pradhan, Arnab; Herrero-de-Dios, Carmen; Belmonte, Rodrigo; Budge, Susan; Lopez Garcia, Angela; Kolmogorova, Aljona; Lee, Keunsook K; Martin, Brennan D; Ribeiro, Antonio; Bebes, Attila; Yuecel, Raif; Gow, Neil A R; Munro, Carol A; MacCallum, Donna M; Quinn, Janet; Brown, Alistair J P

    2017-05-01

    Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen species (ROS) is an essential component of these responses. We showed previously that ectopic expression of the heme-containing catalase enzyme in Candida albicans enhances resistance to oxidative stress, combinatorial oxidative plus cationic stress, and phagocytic killing. Clearly ectopic catalase expression confers fitness advantages in the presence of stress, and therefore in this study we tested whether it enhances fitness in the absence of stress. We addressed this using a set of congenic barcoded C. albicans strains that include doxycycline-conditional tetON-CAT1 expressors. We show that high basal catalase levels, rather than CAT1 induction following stress imposition, reduce ROS accumulation and cell death, thereby promoting resistance to acute peroxide or combinatorial stress. This conclusion is reinforced by our analyses of phenotypically diverse clinical isolates and the impact of stochastic variation in catalase expression upon stress resistance in genetically homogeneous C. albicans populations. Accordingly, cat1Δ cells are more sensitive to neutrophil killing. However, we find that catalase inactivation does not attenuate C. albicans virulence in mouse or invertebrate models of systemic candidiasis. Furthermore, our direct comparisons of fitness in vitro using isogenic barcoded CAT1, cat1Δ and tetON-CAT1 strains show that, while ectopic catalase expression confers a fitness advantage during peroxide stress, it confers a fitness defect in the absence of stress. This fitness defect is suppressed by iron supplementation. Also high basal catalase levels induce key iron assimilatory functions (CFL5, FET3, FRP1, FTR1). We conclude that while high basal catalase levels enhance peroxide stress resistance, they place pressure on iron homeostasis through an elevated cellular demand for iron, thereby reducing the fitness of C. albicans in iron-limiting tissues within the host.

  10. The Sensitivity of Precocious Child Writers: More Evidence of the Double-Edged Sword

    Science.gov (United States)

    Edmunds, Alan L.; Edmunds, Gail

    2014-01-01

    This article provides further evidence of the often observed sensitive nature displayed by children who are gifted. It also addresses the positive and negative effects that this sensitivity can have on these individuals. Earlier, the authors explored this concept through an analysis of the works and life experiences of Geoffrey, aged 9, a prolific…

  11. Familiarity, ambivalence, and firm reputation: is corporate fame a double-edged sword?

    Science.gov (United States)

    Brooks, Margaret E; Highhouse, Scott; Russell, Steven S; Mohr, David C

    2003-10-01

    This research questioned the proposition that corporate familiarity is positively associated with firm reputation. Student images of familiar and unfamiliar Fortune 500 corporations were examined in 4 experiments. The results suggested that, consistent with behavioral decision theory and attitude theory, highly familiar corporations provide information that is more compatible with the tasks of both admiring and condemning than less familiar corporations. Furthermore, the judgment context may determine whether positive or negative judgments are reported about familiar companies. The notion that people can simultaneously hold contradictory images of well-known firms may help to explain the inconsistent findings on the relation between familiarity and reputation.

  12. Mycobacterium tuberculosis lipoproteins in virulence and immunity - fighting with a double-edged sword.

    Science.gov (United States)

    Becker, Katja; Sander, Peter

    2016-11-01

    Bacterial lipoproteins are secreted membrane-anchored proteins characterized by a lipobox motif. This lipobox motif directs post-translational modifications at the conserved cysteine through the consecutive action of three enzymes: Lgt, LspA and Lnt, which results in di- or triacylated forms. Lipoproteins are abundant in all bacteria including Mycobacterium tuberculosis and often involved in virulence and immunoregulatory processes. On the one hand, disruption of the biosynthesis pathway of lipoproteins leads to attenuation of M. tuberculosis in vivo, and mycobacteria deficient for certain lipoproteins have been assessed as attenuated live vaccine candidates. On the other hand, several mycobacterial lipoproteins form immunodominant antigens which promote an immune response. Some of these have been explored in DNA or subunit vaccination approaches against tuberculosis. The immune recognition of specific lipoproteins, however, might also benefit long-term survival of M. tuberculosis through immune modulation, while others induce protective responses. Exploiting lipoproteins as vaccines is thus a complex matter which requires deliberative investigation. The dual role of lipoproteins in the immunity to and pathogenicity of mycobacteria is discussed here. © 2016 Federation of European Biochemical Societies.

  13. The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hance, Michael W.; Nolan, Krystal D.; Isaacs, Jennifer S., E-mail: isaacsj@musc.edu [Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC 29412 (United States)

    2014-05-06

    Heat shock proteins (Hsps) represent a diverse group of chaperones that play a vital role in the protection of cells against numerous environmental stresses. Although our understanding of chaperone biology has deepened over the last decade, the “atypical” extracellular functions of Hsps have remained somewhat enigmatic and comparatively understudied. The heat shock protein 90 (Hsp90) chaperone is a prototypic model for an Hsp family member exhibiting a duality of intracellular and extracellular functions. Intracellular Hsp90 is best known as a master regulator of protein folding. Cancers are particularly adept at exploiting this function of Hsp90, providing the impetus for the robust clinical development of small molecule Hsp90 inhibitors. However, in addition to its maintenance of protein homeostasis, Hsp90 has also been identified as an extracellular protein. Although early reports ascribed immunoregulatory functions to extracellular Hsp90 (eHsp90), recent studies have illuminated expanded functions for eHsp90 in wound healing and cancer. While the intended physiological role of eHsp90 remains enigmatic, its evolutionarily conserved functions in wound healing are easily co-opted during malignancy, a pathology sharing many properties of wounded tissue. This review will highlight the emerging functions of eHsp90 and shed light on its seemingly dichotomous roles as a benevolent facilitator of wound healing and as a sinister effector of tumor progression.

  14. Fear and Attraction in Statecraft: Western Multilateralism’s Double-Edged Swords

    Science.gov (United States)

    2013-06-01

    Zara Steiner, The Lights that Failed: European International History 1919–1933 (Oxford: Oxford University Press, 2005) 1–5. 111 Gray, War, Peace and...Steven E. Miller, 104– 140. Cambridge, MA: The MIT Press, 2001. Steiner, Zara . The Lights that Failed: European International History 1919–1933. Oxford

  15. Evaluation of double drop beads pavement edge lines.

    Science.gov (United States)

    2009-08-01

    This report presents an evaluation of Double Drop Bead (DDB) edge lines used on ALDOT-maintained highways. It compares DDB to three other pavement marking types in terms of service lives, life-cycle costs, and both dry-night retroreflectivity and wet...

  16. A double-edged sword: lactation consultants' perceptions of the impact of breast pumps on the practice of breastfeeding.

    Science.gov (United States)

    Buckley, Kathleen M

    2009-01-01

    This qualitative descriptive study examined the beliefs and experiences of 12 lactation consultants regarding the impact of breast pumps on breastfeeding practices. Interview topics on breast pumps included types and patterns of use, mothers' experiences, and advantages and risks. The lactation consultants reported an increase in the use of breast pumps due to improved marketing, a change in society's view of pumps as a necessity rather than a luxury, and the impact of birthing technology. Reasons given for this increased use were mothers' need to have greater control over the breastfeeding process and to quantify the amount of breastmilk. Concerns were expressed regarding an overdependency on breastfeeding technology by some lactation consultants and mothers.

  17. Microtubule-Targeting Agents Enter the Central Nervous System (CNS): Double-edged Swords for Treating CNS Injury and Disease.

    Science.gov (United States)

    Hur, Eun-Mi; Lee, Byoung Dae

    2014-12-01

    Microtubules have been among the most successful targets in anticancer therapy and a large number of microtubule-targeting agents (MTAs) are in various stages of clinical development for the treatment of several malignancies. Given that injury and diseases in the central nervous system (CNS) are accompanied by acute or chronic disruption of the structural integrity of neurons and that microtubules provide structural support for the nervous system at cellular and intracellular levels, microtubules are emerging as potential therapeutic targets for treating CNS disorders. It has been postulated that exogenous application of MTAs might prevent the breakdown or degradation of microtubules after injury or during neurodegeneration, which will thereby aid in preserving the structural integrity and function of the nervous system. Here we review recent evidence that supports this notion and also discuss potential risks of targeting microtubules as a therapy for treating nerve injury and neurodegenerative diseases.

  18. A Double-Edged Sword? On the Benefit, Detriment, and Net Effect of Dimensional Comparison on Self-Concept

    Science.gov (United States)

    Müller-Kalthoff, Hanno; Jansen, Malte; Schiefer, Irene M.; Helm, Friederike; Nagy, Nicole; Möller, Jens

    2017-01-01

    Dimensional comparison theory (DCT; Möller & Marsh, 2013) assumes that students compare their academic achievement intraindividually across domains to form domain-specific self-concepts. Upward dimensional comparisons are believed to lead to lower self-concepts in the worse-off domain, while downward dimensional comparisons should lead to…

  19. A Double-Edged Sword: The Merits and the Policy Implications of Google Translate in Higher Education

    Science.gov (United States)

    Mundt, Klaus; Groves, Michael

    2016-01-01

    Machine translation, specifically Google Translate, is freely available, and is improving in its ability to provide grammatically accurate translations. This development has the potential to provoke a major transformation in the internationalization process at universities, since students may be, in the future, able to use technology to circumvent…

  20. Extending Antecedents of Achievement Goals: The Double-Edged Sword Effect of Social-Oriented Achievement Motive and Gender Differences

    Science.gov (United States)

    Nie, Youyan; Liem, Gregory Arief D.

    2013-01-01

    Underpinned by the hierarchical model of approach and avoidance motivation, the study examined the differential relations of individual-oriented and social-oriented achievement motives to approach and avoidance achievement goals (mastery-approach, performance-approach, mastery-avoidance, performance-avoidance). A total of 570 Chinese high school…

  1. Microtubule-Targeting Agents Enter the Central Nervous System (CNS: Double-edged Swords for Treating CNS Injury and Disease

    Directory of Open Access Journals (Sweden)

    Eun-Mi Hur

    2014-12-01

    Full Text Available Microtubules have been among the most successful targets in anticancer therapy and a large number of microtubule-targeting agents (MTAs are in various stages of clinical development for the treatment of several malignancies. Given that injury and diseases in the central nervous system (CNS are accompanied by acute or chronic disruption of the structural integrity of neurons and that microtubules provide structural support for the nervous system at cellular and intracellular levels, microtubules are emerging as potential therapeutic targets for treating CNS disorders. It has been postulated that exogenous application of MTAs might prevent the breakdown or degradation of microtubules after injury or during neurodegeneration, which will thereby aid in preserving the structural integrity and function of the nervous system. Here we review recent evidence that supports this notion and also discuss potential risks of targeting microtubules as a therapy for treating nerve injury and neurodegenerative diseases.

  2. Can We Afford These Affordances? GarageBand and the Double-Edged Sword of the Digital Audio Workstation

    Science.gov (United States)

    Bell, Adam Patrick

    2015-01-01

    The proliferation of computers, tablets, and smartphones has resulted in digital audio workstations (DAWs) such as GarageBand in being some of the most widely distributed musical instruments. Positing that software designers are dictating the music education of DAW-dependent music-makers, I examine the fallacy that music-making applications such…

  3. A double-edged sword: the effects of challenge and hindrance time pressure on new product development teams

    NARCIS (Netherlands)

    Chong, D.S.F.; van Eerde, W.; Chai, K.H.; Rutte, C.G.

    2011-01-01

    Bringing new products to market requires team effort. New product development teams often face demanding schedules and high deliverable expectations, making time pressure a common experience at the workplace. Past literature have generally associated the relationship between time pressure and

  4. Massing in high shear wet granulation can simultaneously improve powder flow and deteriorate powder compaction: a double-edged sword.

    Science.gov (United States)

    Shi, Limin; Feng, Yushi; Sun, Changquan Calvin

    2011-05-18

    The influence of massing during high shear wet granulation (HSWG) process on granule properties and performance was investigated using microcrystalline cellulose (MCC). Massing time varied from 0 to 40 min while other factors were fixed. Granule physical properties, including morphology, size, porosity, and specific surface area (SSA), were characterized. Changes in powder properties were profound in the first 10 min of massing but negligible beyond 10 min. With 10 min of massing, granule tabletability decreased by 75% while flowability increased by 75%. The significantly deteriorated tabletability and improved flowability resulted from dramatic changes in granule morphology, porosity, and SSA. The results confirm that massing time is a key process parameter in HSWG, and it must be carefully evaluated and controlled during process development, scale up, and manufacturing. Copyright © 2011 Elsevier B.V. All rights reserved.

  5. The Double-Edged Sword in Pathogenic Trypanosomatids: The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics

    Directory of Open Access Journals (Sweden)

    Rubem Figueiredo Sadok Menna-Barreto

    2014-01-01

    Full Text Available The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. are the causative agents of African trypanosomiasis, Chagas disease, and leishmaniasis, respectively. These diseases are considered to be neglected tropical illnesses that persist under conditions of poverty and are concentrated in impoverished populations in the developing world. Novel efficient and nontoxic drugs are urgently needed as substitutes for the currently limited chemotherapy. Trypanosomatids display a single mitochondrion with several peculiar features, such as the presence of different energetic and antioxidant enzymes and a specific arrangement of mitochondrial DNA (kinetoplast DNA. Due to mitochondrial differences between mammals and trypanosomatids, this organelle is an excellent candidate for drug intervention. Additionally, during trypanosomatids’ life cycle, the shape and functional plasticity of their single mitochondrion undergo profound alterations, reflecting adaptation to different environments. In an uncoupling situation, the organelle produces high amounts of reactive oxygen species. However, these species role in parasite biology is still controversial, involving parasite death, cell signalling, or even proliferation. Novel perspectives on trypanosomatid-targeting chemotherapy could be developed based on better comprehension of mitochondrial oxidative regulation processes.

  6. The 'Double-Edged Sword' of high-feature products: an explorative study of the business impact

    NARCIS (Netherlands)

    Keijzers, J.; Ouden, den P.H.; Lu, Y.

    2008-01-01

    In high-technology consumer markets, manufacturers integrate a growing number of technologies and features to satisfy consumers' preference for high-feature products. At the same time, companies report an increasing number of consumer complaints and even product returns, not due to product faults

  7. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword.

    Science.gov (United States)

    Chen, Jun; Lariviere, William R

    2010-10-01

    Bee venom injection as a therapy, like many other complementary and alternative medicine approaches, has been used for thousands of years to attempt to alleviate a range of diseases including arthritis. More recently, additional theraupeutic goals have been added to the list of diseases making this a critical time to evaluate the evidence for the beneficial and adverse effects of bee venom injection. Although reports of pain reduction (analgesic and antinociceptive) and anti-inflammatory effects of bee venom injection are accumulating in the literature, it is common knowledge that bee venom stings are painful and produce inflammation. In addition, a significant number of studies have been performed in the past decade highlighting that injection of bee venom and components of bee venom produce significant signs of pain or nociception, inflammation and many effects at multiple levels of immediate, acute and prolonged pain processes. This report reviews the extensive new data regarding the deleterious effects of bee venom injection in people and animals, our current understanding of the responsible underlying mechanisms and critical venom components, and provides a critical evaluation of reports of the beneficial effects of bee venom injection in people and animals and the proposed underlying mechanisms. Although further studies are required to make firm conclusions, therapeutic bee venom injection may be beneficial for some patients, but may also be harmful. This report highlights key patterns of results, critical shortcomings, and essential areas requiring further study. Copyright 2010 Elsevier Ltd. All rights reserved.

  8. The double-edged sword of leader charisma: Understanding the curvilinear relationship between charismatic personality and leader effectiveness.

    Science.gov (United States)

    Vergauwe, Jasmine; Wille, Bart; Hofmans, Joeri; Kaiser, Robert B; De Fruyt, Filip

    2018-01-01

    This study advanced knowledge on charisma by (a) introducing a new personality-based model to conceptualize and assess charisma and by (b) investigating curvilinear relationships between charismatic personality and leader effectiveness. Moreover, we delved deeper into this curvilinear association by (c) examining moderation by the leader's level of adjustment and by (d) testing a process model through which the effects of charismatic personality on effectiveness are explained with a consideration of specific leader behaviors. Study 1 validated HDS charisma (Hogan Development Survey) as a useful trait-based measure of charisma. In Study 2 a sample of leaders (N = 306) were assessed in the context of a 360-degree development center. In line with the too-much-of-a-good-thing effect, an inverted U-shaped relationship between charismatic personality and observer-rated leader effectiveness was found, indicating that moderate levels are better than low or high levels of charisma. Study 3 (N = 287) replicated this curvilinear relationship and further illustrated the moderating role of leader adjustment, in such a way that the inflection point after which the effects of charisma turn negative occurs at higher levels of charisma when adjustment is high. Nonlinear mediation modeling further confirmed that strategic and operational leader behaviors fully mediate the curvilinear relationship. Leaders low on charisma are less effective because they lack strategic behavior; highly charismatic leaders are less effective because they lack operational behavior. In sum, this work provides insight into the dispositional nature of charisma and uncovers the processes through which and conditions under which leader charisma translates into (in)effectiveness. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  9. Gendered Uncertainty and Variation in Physicians' Decisions for Coronary Heart Disease: The Double-Edged Sword of "Atypical Symptoms"

    Science.gov (United States)

    Welch, Lisa C.; Lutfey, Karen E.; Gerstenberger, Eric; Grace, Matthew

    2012-01-01

    Nonmedical factors and diagnostic certainty contribute to variation in clinical decision making, but the process by which this occurs remains unclear. We examine how physicians' interpretations of patient sex-gender affect diagnostic certainty and, in turn, decision making for coronary heart disease. Data are from a factorial experiment of 256…

  10. Is self-esteem a "double edged sword"? Self-esteem and the onset of adolescent sexual activity

    OpenAIRE

    Favara, Marta

    2013-01-01

    Self-esteem has been conceptualized as a "social vaccine". The belief is that high self-esteem can inoculate young people, against vulnerability to a wide range of social illnesses. This study gives a contribution in the understanding of the causal relation between self-esteem and sexual behaviour among American adolescents. I analyzes the impact of different levels of early self-esteem on a wide set of risky sexual behaviours. I use data from the National Longitudinal Study of Adolescent Hea...

  11. A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to Treponema pallidum?

    Science.gov (United States)

    Rekart, Michael L; Ndifon, Wilfred; Brunham, Robert C; Dushoff, Jonathan; Park, Sang Woo; Rawat, Sanjana; Cameron, Caroline E

    2017-08-01

    Recently, the world has experienced a rapidly escalating outbreak of infectious syphilis primarily affecting men who have sex with men (MSM); many are taking highly active antiretroviral therapy (HAART) for HIV-1 infection. The prevailing hypothesis is that HAART availability and effectiveness have led to the perception among both individuals who are HIV-1 infected and those who are uninfected that HIV-1 transmission has become much less likely, and the effects of HIV-1 infection less deadly. This is expected to result in increased sexual risk-taking, especially unprotected anal intercourse, leading to more non-HIV-1 STDs, including gonorrhoea, chlamydia and syphilis. However, syphilis incidence has increased more rapidly than other STDs. We hypothesise that HAART downregulates the innate and acquired immune responses to Treponema pallidum and that this biological explanation plays an important role in the syphilis epidemic. We performed a literature search and developed a mathematical model of HIV-1 and T. pallidum confection in a population with two risk groups with assortative mixing to explore the consequence on syphilis prevalence of HAART-induced changes in behaviour versus HAART-induced biological effects. Since rising syphilis incidence appears to have outpaced gonorrhoea and chlamydia, predominantly affecting HIV-1 positive MSM, behavioural factors alone may be insufficient to explain the unique, sharp increase in syphilis incidence. HAART agents have the potential to alter the innate and acquired immune responses in ways that may enhance susceptibility to T. pallidum . This raises the possibility that therapeutic and preventative HAART may inadvertently increase the incidence of syphilis, a situation that would have significant and global public health implications. We propose that additional studies investigating the interplay between HAART and enhanced T. pallidum susceptibility are needed. If our hypothesis is correct, HAART should be combined with enhanced patient management including frequent monitoring for pathogens such as T. pallidum . Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. Work hours and work-family conflict: the double-edged sword of involvement in work and family.

    Science.gov (United States)

    Matthews, Russell A; Swody, Cathleen A; Barnes-Farrell, Janet L

    2012-08-01

    In this study, we examine the role of work hours in a model that incorporates involvement in both work and family with experiences of work-family conflict and subjective well-being. Self-report data were collected from 383 full-time employees and analysed using structural equation modelling techniques. Results demonstrate that role salience was positively related to behavioural involvement with work and with family. In turn, behavioural family involvement was negatively related to work hours and family-to-work conflict, while behavioural work involvement was positively related to work hours. Behavioural family involvement was also positively related to life satisfaction. Finally, both family-to-work conflict and end-of-workday strain were negatively related to life satisfaction. Our results provide insight into unexpected problems that might arise when employees place overly high importance on work and work long hours. This study serves as a foundation for researchers to examine the interplay of time spent with work and family with other aspects of the work-family interface. Copyright © 2011 John Wiley & Sons, Ltd.

  13. Qingping Straight Sword: The Last Remaining Chinese Sword System?

    Directory of Open Access Journals (Sweden)

    Stephan Berwick

    2012-07-01

    Full Text Available The following examination of classical Chinese straight sword (jian details the very rare Qingping straight sword system. The study meshes Chinese- and English-sourced research with a revealing interview (conducted by America’s senior Qingping disciples, Reza Momenan and Hon Lee with Lu Junhai—the grandmaster of this unique sword system. The author presents Qingping system as perhaps the only known, complete Chinese sword system surviving from China’s pre-Rebulican era (1911-1949.

  14. Optimal Shape of a Gamma-ray Collimator: single vs double knife edge

    Science.gov (United States)

    Metz, Albert; Hogenbirk, Alfred

    2017-09-01

    Gamma-ray collimators in nuclear waste scanners are used for selecting a narrow vertical segment in activity measurements of waste vessels. The system that is used by NRG uses tapered slit collimators of both the single and double knife edge type. The properties of these collimators were investigated by means of Monte Carlo simulations. We found that single knife edge collimators are highly preferable for a conservative estimate of the activity of the waste vessels. These collimators show much less dependence on the angle of incidence of the radiation than double knife edge collimators. This conclusion also applies to cylindrical collimators of the single knife edge type, that are generally used in medical imaging spectroscopy.

  15. Edge effects in vertically-oriented graphene based electric double-layer capacitors

    Science.gov (United States)

    Yang, Huachao; Yang, Jinyuan; Bo, Zheng; Zhang, Shuo; Yan, Jianhua; Cen, Kefa

    2016-08-01

    Vertically-oriented graphenes (VGs) have been demonstrated as a promising active material for electric double-layer capacitors (EDLCs), partially due to their edge-enriched structure. In this work, the 'edge effects', i.e., edges as the promoters of high capacitance, in VG based EDLCs are investigated with experimental research and numerical simulations. VGs with diverse heights (i.e., edge-to-basal ratios) and edge densities are prepared with varying the plasma-enabled growth time and employing different plasma sources. Electrochemical measurements show that the edges play a predominant role on the charge storage behavior of VGs. A simulation is further conducted to unveil the roles of the edges on the separation and adsorption of ions within VG channels. The initial charge distribution of a VG plane is obtained with density functional theory (DFT) calculations, which is subsequently applied to a molecular dynamics (MD) simulation system to gain the insights into the microscope EDLC structures. Compared with the basal planes, the edges present higher initial charge density (by 4.2 times), higher ion packing density (by 2.6 times), closer ion packing location (by 0.8 Å), and larger ion separation degree (by 14%). The as-obtained findings will be instructive in designing the morphology and structure of VGs for enhanced capacitive performances.

  16. Double-electron excitation above Xe K-edge

    International Nuclear Information System (INIS)

    Ito, Y.; Tochio, T.; Vlaicu, A.M.; Mutaguchi, K.; OhHashi, H.; Shigeoka, N.; Nakata, Y.; Akahama, Y.; Uruga, T.; Emura, Sh.

    2000-01-01

    When X-rays fall on any substance, whether solid, liquid, or gaseous, a photoabsorption occurs. Photoabsorption in atoms has been generally treated as a single-electron excitation process. However, the existence of the multi-electron excitation process, where the removal of a core electron by photoabsorption causes excitation of additional electrons in the same atoms, has been known in x-ray absorption spectra for a long time. In x-ray absorption spectra, experimental investigations of the shake processes in inner-shell ionization phenomena have been performed by detecting discontinuities. The shake effect which is a consequence of rearrangement of the atomic electrons, occurs in association with inner-shell excitation and ionization phenomena in x-ray absorption. The shake process has been studied extensively in various gases, because it is usually considered that the measurement of the multi-electron excitation is only possible for monatomic gases or vapors. The x-ray absorption spectra in Kr gas were measured by Ito et al. in order to observe precisely x-ray absorption spectra and to investigate the multi-electron excitation cross sections in Kr as a function of photon energy using synchrotron radiation. However, no suitable measured K x-ray absorption spectra was available to elucidate the shake processes. In the present work, the photoabsorption cross sections in Xe have been precisely measured in order to determine the features on the shake processes resulting from multiple electron excitations as a function of photon energy. Double-electron transitions of [1s4d], [1s4p], [1s4s], and [1s3d] are first detected. (author)

  17. Synucleins: are they two-edged swords?

    Science.gov (United States)

    Surguchov, Andrei

    2013-02-01

    The synuclein family consists of three distinct highly homologous genes, α-synuclein, β-synuclein, and γ-synuclein, which have so far been found only in vertebrates. Proteins encoded by these genes are characterized by an acidic C-terminal region and five or six imperfect repeat motifs (KTKEGV) distributed throughout the highly conserved N-terminal region. Numerous data demonstrate that synucleins are implicated in two groups of the most devastating human disorders, i.e., neurodegenerative diseases (NDDs) and cancer. Mutations in the α-synuclein gene are associated with familial forms of Parkinson's disease (PD), and accumulation of α-synuclein inclusions is a hallmark of this disorder. In breast cancer, increased expression of γ-synuclein correlates with disease progression. Conversely, some results indicate that the members of the synuclein family may have a protective effect. How might these small proteins combine such controversial properties? We present evidence that synuclein's features are basically regulated by two mechanisms, i.e., posttranslational modifications (PTMs) and the level of their expression. We also discuss a new, emerging area of investigation of synucleins, namely, their role in the cell-to-cell propagation of pathology. Copyright © 2012 Wiley Periodicals, Inc.

  18. Re-investigation on reduced graphene oxide/Ag{sub 2}CO{sub 3} composite photocatalyst: An insight into the double-edged sword role of RGO

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wenguang [School of Materials and Energy, Guangdong University of Technology, Guangzhou Higher Education Mega Center 100#, Guangzhou, 510006 (China); Key Laboratory of Renewable Energy, Chinese Academy of Sciences, Guangzhou, 510640 (China); Liu, Yuan [School of Materials and Energy, Guangdong University of Technology, Guangzhou Higher Education Mega Center 100#, Guangzhou, 510006 (China); Zhang, Haiyan, E-mail: hyzhang@gdut.edu.cn [School of Materials and Energy, Guangdong University of Technology, Guangzhou Higher Education Mega Center 100#, Guangzhou, 510006 (China); Qian, Yannan; Guo, Zuchen [School of Materials and Energy, Guangdong University of Technology, Guangzhou Higher Education Mega Center 100#, Guangzhou, 510006 (China)

    2017-02-28

    Highlights: • Reduced graphene oxide can improve the photocatalytic activity of Ag{sub 2}CO{sub 3}. • Reduced graphene oxide plays a negative role to the cycling stability of Ag{sub 2}CO{sub 3}. • The mechanism for the morphology change of pure Ag{sub 2}CO{sub 3} and Ag{sub 2}CO{sub 3}/RGO is proposed. - Abstract: Coupling graphene or reduced graphene oxide (RGO) with semiconductor photocatalysts has previously been proven to be an effective way for enhancing the photocatalytic activity and stability of the photocatalysts. Herein, the Ag{sub 2}CO{sub 3}/reduced graphene oxide composite was successfully prepared by a facile chemical precipitation method. The physical and chemical properties of the photocatalysts were characterized by X-ray diffraction, Raman spectra, scanning electron microscope, X-ray photoelectron spectroscopy, UV–vis diffuse-reflection spectra. The photocatalytic activity and cycling stability of the photocatalysts were evaluated by photocatalytic degradation of rhodamine B under visible light irradiation. The results showed that the RGO indeed improves the photocatalytic activity of Ag{sub 2}CO{sub 3}/RGO, which can be attributed to the reduced charge recombination and enhanced dye adsorption as well as the light harvesting by RGO. Nevertheless, it played a negative role to the photocatalytic cycling stability due to the strong aggregation of Ag{sub 2}CO{sub 3} particles brought by the RGO sheets. This work may provide a re-examination of the role of RGO in enhancing the photocatalytic performances of the photocatalysts.

  19. Surgery as a Double-Edged Sword: A Clinically Feasible Approach to Overcome the Metastasis-Promoting Effects of Surgery by Blunting Stress and Prostaglandin Responses

    International Nuclear Information System (INIS)

    Benish, Marganit; Ben-Eliyahu, Shamgar

    2010-01-01

    Surgery remains an essential therapeutic approach for most solid malignancies, including breast cancer. However, surgery also constitutes a risk factor for promotion of pre-existing micrometastases and the initiation of new metastases through several mechanisms, including the release of prostaglandins and stress hormones (e.g., catecholamines and glucocorticoids). However, the perioperative period also presents an opportunity for cell mediated immunity (CMI) and other mechanisms to eradicate or control minimal residual disease, provided that the deleterious effects of surgery are minimized. Here, we discuss the key role of endogenous stress hormones and prostaglandins in promoting the metastatic process through their direct impact on malignant cells, and through their deleterious impact on anti-cancer CMI. We further discuss the effects of anesthetic techniques, the extent of surgery, pain alleviation, and timing within the menstrual cycle with respect to their impact on tumor recurrence and physiological stress responses. Last, we suggest an attractive perioperative drug regimen, based on a combination of a cyclooxygenase (COX)-2 inhibitor and a β-adrenergic blocker, which we found effective in attenuating immune suppression and the metastasis-promoting effects of surgery in several tumor models. This regimen is clinically applicable, and could potentially promote disease free survival in patients operated for breast and other types of cancer

  20. Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.

    Science.gov (United States)

    Zhuang, Chunlin; Miao, Zhenyuan; Wu, Yuelin; Guo, Zizhao; Li, Jin; Yao, Jianzhong; Xing, Chengguo; Sheng, Chunquan; Zhang, Wannian

    2014-02-13

    Simultaneous inactivation of p53 and hyperactivation of nuclear factor-κB (NF-κB) is a common occurrence in human cancer. Currently, antitumor agents are being designed to selectively activate p53 or inhibit NF-κB. However, there is no concerted effort yet to deliberately design inhibitors that can simultaneously do both. This paper provided a proof-of-concept study that p53-MDM2 interaction and NF-κB pathway can be simultaneously targeted by a small-molecule inhibitor. A series of pyrrolo[3,4-c]pyrazole derivatives were rationally designed and synthesized as the first-in-class inhibitors of p53-MDM2 interaction and NF-κB pathway. Most of the compounds were identified to possess nanomolar p53-MDM2 inhibitory activity. Compounds 5q and 5s suppressed NF-κB activation through inhibition of IκBα phosphorylation and elevation of the cytoplasmic levels of p65 and phosphorylated IKKα/β. Biochemical assay for the kinases also supported the fact that pyrrolo[3,4-c]pyrazole compounds directly targeted the NF-κB pathway. In addition, four compounds (5j, 5q, 5s, and 5u) effectively inhibited tumor growth in the A549 xenograft model. Further pharmacokinetic study revealed that compound 5q exhibited excellent oral bioavailability (72.9%).

  1. Re-investigation on reduced graphene oxide/Ag2CO3 composite photocatalyst: An insight into the double-edged sword role of RGO

    Science.gov (United States)

    Wang, Wenguang; Liu, Yuan; Zhang, Haiyan; Qian, Yannan; Guo, Zuchen

    2017-02-01

    Coupling graphene or reduced graphene oxide (RGO) with semiconductor photocatalysts has previously been proven to be an effective way for enhancing the photocatalytic activity and stability of the photocatalysts. Herein, the Ag2CO3/reduced graphene oxide composite was successfully prepared by a facile chemical precipitation method. The physical and chemical properties of the photocatalysts were characterized by X-ray diffraction, Raman spectra, scanning electron microscope, X-ray photoelectron spectroscopy, UV-vis diffuse-reflection spectra. The photocatalytic activity and cycling stability of the photocatalysts were evaluated by photocatalytic degradation of rhodamine B under visible light irradiation. The results showed that the RGO indeed improves the photocatalytic activity of Ag2CO3/RGO, which can be attributed to the reduced charge recombination and enhanced dye adsorption as well as the light harvesting by RGO. Nevertheless, it played a negative role to the photocatalytic cycling stability due to the strong aggregation of Ag2CO3 particles brought by the RGO sheets. This work may provide a re-examination of the role of RGO in enhancing the photocatalytic performances of the photocatalysts.

  2. Bilingualism with and without CLIL, a Double-Edged Sword: Comparing Bilingual and Non Bilingual Young Learners' Beliefs about EFL and Science Learning

    Science.gov (United States)

    Sandoval Brotons, Alfonso Victor

    2015-01-01

    Bilingualism and its reference methodology: CLIL are spreading at a very fast pace all through educative systems from some years on. The young status of bilingual programmes leads to little research about how bilingualism is influencing real learning contexts and which factors play important roles in that influence. In this way, this study aims to…

  3. Learner Dashboards a Double-Edged Sword? Students' Sense-Making of a Collaborative Critical Reading and Learning Analytics Environment for Fostering 21st-Century Literacies

    Science.gov (United States)

    Pei-Ling Tan, Jennifer; Koh, Elizabeth; Jonathan, Christin; Yang, Simon

    2017-01-01

    The affordances of learning analytics (LA) tools and solutions are being increasingly harnessed for enhancing 21st century pedagogical and learning strategies and outcomes. However, use cases and empirical understandings of students' experiences with LA tools and environments aimed at fostering 21st century literacies, especially in the K-12…

  4. Is Job Control a Double-Edged Sword? A Cross-Lagged Panel Study on the Interplay of Quantitative Workload, Emotional Dissonance, and Job Control on Emotional Exhaustion.

    Science.gov (United States)

    Konze, Anne-Kathrin; Rivkin, Wladislaw; Schmidt, Klaus-Helmut

    2017-12-20

    Previous meta-analytic findings have provided ambiguous evidence on job control as a buffering moderator of the adverse impact of job demands on psychological well-being. To disentangle these mixed findings, we examine the moderating effect of job control on the adverse effects of quantitative workload and emotional dissonance as distinct work-related demands on emotional exhaustion over time. Drawing on the job demands-control model, the limited strength model of self-control, and the matching principle we propose that job control can facilitate coping with work-related demands but at the same time may also require employees' self-control. Consequently, we argue that job control buffers the adverse effects of quantitative workload while it reinforces the adverse effects of emotional dissonance, which also necessitates self-control. We examine the proposed relations among employees from an energy supplying company ( N = 139) in a cross-lagged panel study with a six-month time lag. Our results demonstrate a mix of causal and reciprocal effects of job characteristics on emotional exhaustion over time. Furthermore, as suggested, our data provides evidence for contrasting moderating effects of job control. That is, job control buffers the adverse effects of quantitative workload while it reinforces the adverse effects of emotional dissonance on emotional exhaustion.

  5. Should the moral core of climate issues be emphasized or downplayed in public discourse? Three ways to successfully manage the double-edged sword of moral communication

    NARCIS (Netherlands)

    Täuber, Susanne; van Zomeren, Martijn; Kutlaca, Maja

    The main objective of this paper is to identify a serious problem for communicators regarding the framing of climate issues in public discourse, namely that moralizing such an issue can motivate individuals while at the same time defensively lead them to avoid solving the problem. We review recent

  6. Are Academic Discounting and Devaluing Double-Edged Swords? Their Relations to Global Self-Esteem, Achievement Goals, and Performance among Stigmatized Students

    Science.gov (United States)

    Loose, Florence; Regner, Isabelle; Morin, Alexandre J. S.; Dumas, Florence

    2012-01-01

    Often taken for granted, the coexistence of benefits and costs of discounting and devaluing has never been tested. Yet, not only are there inconsistent findings about the relations between these processes and global self-esteem, but little is known about their relations to motivation and performance. Here we simultaneously examined how academic…

  7. Is Job Control a Double-Edged Sword? A Cross-Lagged Panel Study on the Interplay of Quantitative Workload, Emotional Dissonance, and Job Control on Emotional Exhaustion

    Directory of Open Access Journals (Sweden)

    Anne-Kathrin Konze

    2017-12-01

    Full Text Available Previous meta-analytic findings have provided ambiguous evidence on job control as a buffering moderator of the adverse impact of job demands on psychological well-being. To disentangle these mixed findings, we examine the moderating effect of job control on the adverse effects of quantitative workload and emotional dissonance as distinct work-related demands on emotional exhaustion over time. Drawing on the job demands-control model, the limited strength model of self-control, and the matching principle we propose that job control can facilitate coping with work-related demands but at the same time may also require employees’ self-control. Consequently, we argue that job control buffers the adverse effects of quantitative workload while it reinforces the adverse effects of emotional dissonance, which also necessitates self-control. We examine the proposed relations among employees from an energy supplying company (N = 139 in a cross-lagged panel study with a six-month time lag. Our results demonstrate a mix of causal and reciprocal effects of job characteristics on emotional exhaustion over time. Furthermore, as suggested, our data provides evidence for contrasting moderating effects of job control. That is, job control buffers the adverse effects of quantitative workload while it reinforces the adverse effects of emotional dissonance on emotional exhaustion.

  8. The Double Edged Sword: A Brief Comparison of IT and Internet Development in Malaysia and Some Few Neighboring Countries in the Context of Digital Divide.

    Science.gov (United States)

    Samad, Ramli Abdul

    This paper shows that, although a digital divide exists between developed and developing countries, the development of information technology (IT) and the Internet has had a profound political, social, and economic impact on developing countries. IT and the Internet revolution are shaping the world into new polarized entities due to the uneven…

  9. Work Engagement: A Double-Edged Sword? A Study of the Relationship between Work Engagement and the Work-Home Interaction Using the ARK Research Platform

    Directory of Open Access Journals (Sweden)

    Katrine Listau

    2017-07-01

    Full Text Available The aim of the present study was to investigate how being engaged at work affects academics’ work-home interaction. Using the Conservation of Resources theory as a theoretical framework, the study contributes to existing research by examining the relationship between the work engagement subscales (i.e. vigour, dedication, and absorption and both work-home facilitation and work-home conflict. In order to test the hypotheses, a Partial Least Squares-Structural Equation Modelling analysis was conducted using a large sample of academics from the Norwegian university sector (N = 4378. The results indicated that vigour and dedication had a positive relationship with work-home facilitation and a negative relationship with work-home conflict. In contrast, absorption was not significantly related to work-home facilitation, but was positively associated with work-home conflict. Thus, we conclude that work engagement seems to have the potential to create both positive and negative outcomes.

  10. Surgery as a Double-Edged Sword: A Clinically Feasible Approach to Overcome the Metastasis-Promoting Effects of Surgery by Blunting Stress and Prostaglandin Responses

    Energy Technology Data Exchange (ETDEWEB)

    Benish, Marganit; Ben-Eliyahu, Shamgar, E-mail: shamgar@post.tau.ac.il [Neuroimmunology Research Unit, Department of Psychology, Tel Aviv University, Tel Aviv 69978 (Israel)

    2010-11-24

    Surgery remains an essential therapeutic approach for most solid malignancies, including breast cancer. However, surgery also constitutes a risk factor for promotion of pre-existing micrometastases and the initiation of new metastases through several mechanisms, including the release of prostaglandins and stress hormones (e.g., catecholamines and glucocorticoids). However, the perioperative period also presents an opportunity for cell mediated immunity (CMI) and other mechanisms to eradicate or control minimal residual disease, provided that the deleterious effects of surgery are minimized. Here, we discuss the key role of endogenous stress hormones and prostaglandins in promoting the metastatic process through their direct impact on malignant cells, and through their deleterious impact on anti-cancer CMI. We further discuss the effects of anesthetic techniques, the extent of surgery, pain alleviation, and timing within the menstrual cycle with respect to their impact on tumor recurrence and physiological stress responses. Last, we suggest an attractive perioperative drug regimen, based on a combination of a cyclooxygenase (COX)-2 inhibitor and a β-adrenergic blocker, which we found effective in attenuating immune suppression and the metastasis-promoting effects of surgery in several tumor models. This regimen is clinically applicable, and could potentially promote disease free survival in patients operated for breast and other types of cancer.

  11. The Sword of Orion

    Science.gov (United States)

    2006-01-01

    [figure removed for brevity, see original site] [figure removed for brevity, see original site] AnimationFigure 1 This infrared image from NASA's Spitzer Space Telescope shows the Orion nebula, our closest massive star-making factory, 1,450 light-years from Earth. The nebula is close enough to appear to the naked eye as a fuzzy star in the sword of the popular hunter constellation. The nebula itself is located on the lower half of the image, surrounded by a ring of dust. It formed in a cold cloud of gas and dust and contains about 1,000 young stars. These stars illuminate the cloud, creating the beautiful nebulosity, or swirls of material, seen here in infrared. In the center of the nebula (bottom inset of figure 1) are four monstrously massive stars, up to 100,000 times as luminous as our sun, called the Trapezium (tiny yellow smudge to the lower left of green splotches. Radiation and winds from these stars are blasting gas and dust away, excavating a cavity walled in by the large ring of dust. Behind the Trapezium, still buried deeply in the cloud, a second generation of massive stars is forming (in the area with green splotches). The speckled green fuzz in this bright region is created when bullets of gas shoot out from the juvenile stars and ram into the surrounding cloud. Above this region of intense activity are networks of cold material that appear as dark veins against the pinkish nebulosity (upper inset pf figure 1). These dark veins contain embryonic stars. Some of the natal stars illuminate the cloud, creating small, aqua-colored wisps. In addition, jets of gas from the stars ram into the cloud, resulting in the green horseshoe-shaped globs. Spitzer surveyed a significant swath of the Orion constellation, beyond what is highlighted in this image. Within that region, called the Orion cloud complex, the telescope found 2,300 stars circled by disks of planet-forming dust and 200 stellar embryos too young to have developed disks. This image shows infrared

  12. Rational behavior is a ‘double-edged sword’ when considering voluntary vaccination

    Science.gov (United States)

    Zhang, Haifeng; Fu, Feng; Zhang, Wenyao; Wang, Binghong

    2012-10-01

    behavior of individuals plays a ‘double-edged-sword’ role on the social effects.

  13. Parents’ performance in entrepreneurship as a “double-edged sword” for the intergenerational transmission of entrepreneurship

    OpenAIRE

    Criaco, G. (Giuseppe); Sieger, P. (Philipp); Wennberg, K. (Karl); Chirico, F. (Francesco); Minola, T. (Tommaso)

    2017-01-01

    textabstractWe investigate how perceived parents’ performance in entrepreneurship (PPE) affects the entrepreneurial career intentions of offspring. We argue that while perceived PPE enhances offspring’s perceived entrepreneurial desirability and feasibility because of exposure mechanisms, it inhibits the translation of both desirability and feasibility perceptions into entrepreneurial career intentions due to upward social comparison mechanisms. Thus, perceived PPE acts as a double-edged swor...

  14. Evaluation of double drop beads pavement edge lines : SPR project description.

    Science.gov (United States)

    2009-01-01

    In UTCA projects 01465 and 04405, the retroreflectivities and the life cycle costs were measured and compared for standard Alabama Department of Transportation (ALDOT) thermoplastic edge : stripes that contained only one size of retroreflective beads...

  15. Studies of Viking Age swords: metallography and archaeology

    Directory of Open Access Journals (Sweden)

    Elisabeth Astrup, Eva

    2011-12-01

    Full Text Available The paper is a comment on Alan Williams investigation ‘A Metallurgical Study of some Viking Swords’ published in Gladius XXIX. Williams’ paper comprise metallurgical investigations of 44 Viking Age Swords, all with ULFBERHT inscriptions. Such investigations, made by a well qualified metallurgist, are essential to archaeology. Unfortunately, this one has some serious limitations. In order to give a good description of the quality of a sword-blade, samples showing at least the section through both the edge and the central part of the blade are necessary. This is mostly not the case in Williams’ investigations, and he gives insufficient information about his samples. Other weak points are his group division and his interpretation of the production area for blades containing high-carbon steel.

    Este trabajo es un comentario sobre la investigación de Alan Williams ‘A Metallurgical Study of some Viking Swords` publicado en Gladius XXIX. El artículo de Williams incluye un estudio arqueometalúrgico de 44 espadas de época vikinga, todas ellas con la inscripción ULFBERHT. Estas investigaciones, realizadas por un arqueometalúrgico altamente cualificado, son esenciales en arqueología. Sin embargo, esta en concreto presenta algunas serias limitaciones. Para poder proporcionar una buena descripción de la calidad de la hoja de una espada, son necesarias muestras de al menos la sección desde el filo y hasta la parte central de la hoja. Este no es el caso de la mayoría de las muestras de Williams, quien proporciona insuficiente información sobre su toma de muestras. Otros puntos débiles son su clasificación en grupos y su interpretación del área de producción para las hojas que contienen un acero con elevado contenido de carbono.

  16. The cost of the sword: escape performance in male swordtails.

    Directory of Open Access Journals (Sweden)

    Alex Baumgartner

    2011-01-01

    Full Text Available The handicap theory of sexual selection posits that male display traits that are favored in mate choice come at a significant cost to performance. We tested one facet of this hypothesis in the green swordtail (Xiphophorus helleri. In this species, the lower ray of male caudal fin is extended into a 'sword', which serves to attract potential mates. However, bearing a long sword may increase drag and thus compromise a male's ability to swim effectively. We tested escape performance in this species by eliciting C-start escape responses, an instinctive escape behavior, in males with various sword lengths. We then removed males' swords and retested escape performance. We found no relationship between escape performance and sword length and no effect of sword removal on escape performance. While having a large sword may attract a predator's attention, our results suggest that sword size does not compromise a male's escape performance.

  17. The width of jets in powerful edge-brightened extragalactic double radio sources

    International Nuclear Information System (INIS)

    Banhatti, D.G.

    1987-01-01

    The widths of primary and secondary jets are derived from a sample of 14 double hotspots in powerful extended extragalactic double radio sources. In the model employed, the primary jet extends from the core to the more compact primary hotspot and the secondary jet emerges from the primary hotspot and dissipates to form the diffuse secondary hotspot. Mean values of hotspot size/jet extent imply that the primary and secondary jets, if free, must be 2 0 and > 27 0 wide, respectively. (author)

  18. A metallurgical study of some viking swords

    Directory of Open Access Journals (Sweden)

    Williams, Alan

    2009-12-01

    Full Text Available While «pattern-welded» swords have been found all over Europe from sites dating from the Migration Period and into the Early Middle Ages, they were steadily supplanted during the Viking period by swords made out of a few pieces of iron and steel, or even a single piece of steel. Swords with «Ulfberht» or related inscriptions were the most famous of these. The results of the metallurgical study of 44 specimens from «Ulfberht» swords, as well as some other Viking-age swords, together with electron microanalyses carried out on selected examples, are presented here.

    Mientras que se han encontrado en toda Europa espadas forjadas mediante el sistema de ‘pattern welding’ (entrelazado de láminas formando patrones visibles, procedentes de yacimientos que se extienden desde el Periodo de las Migraciones bárbaras hasta la Alta Edad Media, durante el periodo vikingo fueron habitualmente reemplazadas por espadas forjadas a partir de unas pocas piezas de hierro y acero, o incluso de una única pieza de acero. Las más famosas de entre ellas fueron las espadas con la inscripción «Ulfbehrt» u otras relacionadas. Este artículo presenta los resultados del estudio metalúrgico de 44 ejemplares de espadas de «Ulfberht» y otras de época vikinga, así como los microanálisis efectuados sobre algunas muestras seleccionadas.

  19. Iridium Coating Deposited by Double Glow Plasma Technique — Effect of Glow Plasma on Structure of Coating at Single Substrate Edge

    International Nuclear Information System (INIS)

    Wu Wangping; Chen Zhaofeng; Liu Yong

    2012-01-01

    Double glow plasma technique has a high deposition rate for preparing iridium coating. However, the glow plasma can influence the structure of the coating at the single substrate edge. In this study, the iridium coating was prepared by double glow plasma on the surface of single niobium substrate. The microstructure of iridium coating at the substrate edge was observed by scanning electron microscopy. The composition of the coating was confirmed by energy dispersive spectroscopy and X-ray diffraction. There was a boundary between the coating and the substrate edge. The covered area for the iridium coating at the substrate edge became fewer and fewer from the inner area to the outer flange-area. The bamboo sprout-like particles on the surface of the substrate edge were composed of elemental niobium. The substrate edge was composed of the Nb coating and there was a transition zone between the Ir coating and the Nb coating. The interesting phenomenon of the substrate edge could be attributed to the effects of the bias voltages and the plasma cloud in the deposition chamber. The substrate edge effect could be mitigated or eliminated by adding lots of small niobium plates around the substrate in a deposition process. (plasma technology)

  20. Asymptotic theory of double layer and shielding of electric field at the edge of illuminated plasma

    Energy Technology Data Exchange (ETDEWEB)

    Benilov, M. S. [Departamento de Física, CCCEE, Universidade da Madeira, Largo do Município, 9000 Funchal (Portugal); Thomas, D. M. [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom)

    2014-04-15

    The method of matched asymptotic expansions is applied to the problem of a collisionless plasma generated by UV illumination localized in a central part of the plasma in the limiting case of small Debye length λ{sub D}. A second-approximation asymptotic solution is found for the double layer positioned at the boundary of the illuminated region and for the un-illuminated plasma for the plane geometry. Numerical calculations for different values of λ{sub D} are reported and found to confirm the asymptotic results. The net integral space charge of the double layer is asymptotically small, although in the plane geometry it is just sufficient to shield the ambipolar electric field existing in the illuminated region and thus to prevent it from penetrating into the un-illuminated region. The double layer has the same mathematical nature as the intermediate transition layer separating an active plasma and a collisionless sheath, and the underlying physics is also the same. In essence, the two layers represent the same physical object: a transonic layer.

  1. Characterization of two Japanese ancient swords through neutron imaging

    International Nuclear Information System (INIS)

    Grazzi, Francesco; Zoppi, Marco; Salvemini, Filomena; Kaestner, Anders; Lehmann, Eberhard; Civita, Francesco

    2015-01-01

    Japanese blades are culturally interesting objects both from the stylistic point of view and because of their fantastic performances. In this work, we present new results, using a non-invasive approach, concerning these peculiar artefacts. Two integer Japanese swords, pertaining to Kyoto (987-1596) and Shinto (1596-1781) periods have been analysed through neutron-imaging techniques. The experiments have been performed at the ICON beam line, operating at the spallation neutron source SINQ, Paul Scherrer Institut in Switzerland. The reconstruction of projection data into neutron tomographic slices or volumes, allowed us to identify some very peculiar characteristics, related to the forging methods and to the different thermal treatments applied to produce the cutting edge and its unique feature. (author)

  2. Some early medieval swords in the Wallace Collection and elsewhere

    Directory of Open Access Journals (Sweden)

    Edge, David

    2003-12-01

    Full Text Available The analysis of eight early medieval swords shows that some were made from a single piece of steel, while others had a steel cutting edge welded on. Heat-treatment to harden the steel was undertaken in six out of seven cases; the other proved to be a modern replica.

    El análisis de ocho espadas altomedievales muestra que algunas de ellas fueron hechas a partir de una sola pieza de acero, mientras que a otras se les ha soldado un cortante filo de este material. El endurecimiento del acero mediante forja fue realizado en seis de siete casos, mientras que el restante se demostró que era una réplica moderna.

  3. The Sword of Damocles and the Biosphere

    OpenAIRE

    Cairns, John

    2011-01-01

    The tale of the sword of Damocles can be used to describe the sword hanging by a thread over humankind with the damage it is doing to the present biosphere. The sixth biosphere, or the current biosphere, is experiencing a significant reduction in species caused by human-related activities. The signs of risk have markedly increased by the signs differ considerably from one are to another, and people tend do discount global change because it is unnoticeable in their local area. If humans begin...

  4. Core and edge aspects of quiescent double barrier operation on DIII-D, with relevance to critical ITB physics issues

    International Nuclear Information System (INIS)

    Doyle, E.J.; Casper, T.A.; Burrell, K.H.

    2003-01-01

    Recent results from DIII-D address critical internal transport barrier (ITB) research issues relating to sustainability, impurity accumulation and ITB control, and have also demonstrated successful application of general profile control tools. In addition, substantial progress has been made in understanding the physics of the Quiescent Double Barrier (QDB) regime, increasing the demonstrated operating space for the regime and improving performance. Highlights include: (1) A clear demonstration of q-profile modification using electron cyclotron current drive (ECCD); (2) Successful use of localized profile control using electron cyclotron heating (ECH) or ECCD to reduce central high-Z impurity accumulation associated with density peaking; (3) Theory based modeling codes are now being used to design experiments; (4) The operating space for Quiescent H-mode (QH-mode) has been substantially broadened, in particular higher density operation has been achieved; (5) Both absolute (β≤ 3.8%, neutron rate S n ≤ 5.5x10 15 s -1 ) and relative (β N H 89 = 7 for 10τ E ) performance has been increased; (6) With regard to sustainment, QDB plasmas have been run for 3.8 s or 26 τ E . These results emphasize that it is possible to produce sustained high quality H-mode performance with an edge localized mode (ELM)-free edge, directly addressing a major issue in fusion research, of how to ameliorate or eliminate ELM induced pulsed divertor particle and heat loads. (author)

  5. Estimation of Neutral Density in Edge Plasma with Double Null Configuration in EAST

    International Nuclear Information System (INIS)

    Zhang Ling; Xu Guosheng; Ding Siye; Gao Wei; Wu Zhenwei; Chen Yingjie; Huang Juan; Liu Xiaoju; Zang Qing; Chang Jiafeng; Zhang Wei; Li Yingying; Qian Jinping

    2011-01-01

    In this work, population coefficients of hydrogen's n = 3 excited state from the hydrogen collisional-radiative (CR) model, from the data file of DEGAS 2, are used to calculate the photon emissivity coefficients (PECs) of hydrogen Balmer-α (n = 3 → n = 2) (H α ). The results are compared with the PECs from Atomic Data and Analysis Structure (ADAS) database, and a good agreement is found. A magnetic surface-averaged neutral density profile of typical double-null (DN) plasma in EAST is obtained by using FRANTIC, the 1.5-D fluid transport code. It is found that the sum of integral D α and H α emission intensity calculated via the neutral density agrees with the measured results obtained by using the absolutely calibrated multi-channel poloidal photodiode array systems viewing the lower divertor at the last closed flux surface (LCFS). It is revealed that the typical magnetic surface-averaged neutral density at LCFS is about 3.5 x 10 16 m -3 . (magnetically confined plasma)

  6. People vs. Collins: Statistics as a Two-Edged Sword

    Science.gov (United States)

    McGivney-Burelle, Jean; McGivney, Katherine; McGivney, Ray

    2006-01-01

    Real-life applications of the use (and misuse) of mathematics invariably pique students' interest. This article describes a legal case in California that occurred in the 1960s in which a couple was convicted of robbery, in part, based on the expert testimony of a statistics instructor. On appeal, the judge noted several mathematical errors in this…

  7. Gluten: a two-edged sword. Immunopathogenesis of celiac disease

    NARCIS (Netherlands)

    Koning, de F.; Gilissen, L.J.W.J.; Wijmenga, C.

    2005-01-01

    Celiac disease (CD) is a small intestinal disorder caused by adaptive and innate immune responses triggered by the gluten proteins present in wheat. In the intestine, gluten is partially degraded and modified, which results in gluten peptides that bind with high affinity to HLA-DQ2 or HLA-DQ8 and

  8. Free Internet and Social Media: A Dual-Edged Sword

    Science.gov (United States)

    2014-02-13

    perpetuating illiteracy . Would be dissenters would have been restricted to person- to-person verbal communication which was easily detectable due to...For example, in the 1857 Indian revolt, rebels overwhelmed British troops whose last telegraph alerted authorities throughout India of an uprising

  9. Provenance study of a Bronze Age sword from Giurgiu

    International Nuclear Information System (INIS)

    Olariu, Agata; Badica, T.; Popescu, I. V.; Alexandrescu, E.

    2000-01-01

    This work is a compositional study of a bronze sword recently discovered near Giurgiu using the method of charged particles induced X ray emission (PIXE). The sword is of it Reutlingen type dated in the period Bronze Age D - Hallstatt A1, around 1200 B. C. The knowledge of its composition could give supplementary information about the provenance of this sword by comparing with other copper-based alloy objects from Bronze Age. To obtain the composition of the sword we have applied the method PIXE at the Tandem accelerator of IFIN-HH Magurele. We have extracted 3 samples from the body of the sword: one sample from the tip of the sword and 2 samples from the hilt. The samples have been flattened by a hammer and introduced in the irradiation chamber of the PIXE spectrometer. The targets have been irradiated by a current of protons of 3 MeV and about 5 nA from the linear accelerator Tandem of the department. The detection of the characteristic X ray emission have been done by a GeHP detector. The acquisition of the X ray spectra has been done online on a PC with a MCA interface Canberra. The detection system gave a 190 eV resolution at 5.9 keV. In the frame of the experimental conditions the following elements have been observed: As, Co, Cr, Cu, Fe, Ni, Pb, Sn and Zn. In the table we present the results of the PIXE analysis of the Bronze Age sword from Giurgiu. The instrumentation errors have been less than 15%. The values of the elemental concentrations have been normalized to 100%. In order to have a comparative study of composition we considered also the composition of 7 swords of the same type and from the same period from regions from the south of Danube in Bulgaria, and 6 copper-based alloy objects from Spalnaca deposit, in Transylvania, dated also Bronze Age. The sword from Giurgiu has a composition closer to the Bulgarian swords for the elements: As, Co, Cu, Ni, Sn. The ratios Sn/Cu versus As/Cu for the sword from Giurgiu, Spalnaca-Transylvania objects and

  10. The “Double-Edge Sword” of Human Empathy: A Unifying Neurobehavioral Theory of Compassion Stress Injury

    Directory of Open Access Journals (Sweden)

    Mark Russell

    2015-11-01

    Full Text Available An integrative neurobehavioral model for “compassion stress injury” is offered to explain the “double-edge sword” of empathy and inherent vulnerability of helping professionals and care-givers. One of the most strikingly robust, yet largely invisible scientific findings to emerge over the past decade is identifying the neurophysiological mechanisms enabling human beings to understand and feel what another is feeling. The compelling convergence of evidence from multi-disciplinary lines of primary research and studies of paired-deficits has revealed that the phenomenon of human beings witnessing the pain and suffering of others is clearly associated with activation of neural structures used during first-hand experience. Moreover, it is now evident that a large part of the neural activation shared between self- and other-related experiences occurs automatically, outside the observer’s conscious awareness or control. However, it is also well established that full blown human empathic capacity and altruistic behavior is regulated by neural pathways responsible for flexible consciously controlled actions of the observer. We review the history, prevalence, and etiological models of “compassion stress injury” such as burnout, secondary traumatic stress, vicarious traumatization, compassion fatigue, and empathic distress fatigue, along with implications of the neurobehavioral approach in future research.

  11. BibSword Implementation of SWORD client in Invenio for the automated submission of digital objects to arXiv

    CERN Document Server

    Barras, Mathieu; Abou Khaled, Omar; Mugellini, Elena

    2010-01-01

    Since recently, arXiv offers a new submission interface implementing SWORD. SWORD is a brand new protocol that defines a simple way to deposit digital document on web repositories. The most part of digital documents submitted on Invenio are also deposited on arXiv. For this reason, it is a relevant added value for Invenio to offers such an automated “Forward to ArXiv” option to its users. The aim of this project is then to analyse, design and implements a library oriented SWORD client module (BibSword). This module will offer an user interface and will be integrated in the Invenio submission process.

  12. The double-edged effects of annealing MgO underlayers on the efficient synthesis of single-wall carbon nanotube forests.

    Science.gov (United States)

    Tsuji, Takashi; Hata, Kenji; Futaba, Don N; Sakurai, Shunsuke

    2017-11-16

    Recently, the millimetre-scale, highly efficient synthesis of single-wall carbon nanotube (SWCNT) forests from Fe catalysts has been reported through the annealing of the magnesia (MgO) underlayer. Here, we report the double-edged effects of underlayer annealing on the efficiency and structure of the SWCNT forest synthesis through a temperature-dependent examination. Our results showed that the efficiency of the SWCNT forests sharply increased with increased underlayer annealing temperatures from 600 °C up to 900 °C due to a temperature-dependent structural modification, characterized by increased grain size and reduced defects, of the MgO underlayer. Beyond this temperature, the SWCNT fraction also decreased as a result of further structural modification of the MgO underlayer. This exemplifies the double-edged effects of annealing. Specifically, for underlayer annealing below 600 °C, the catalyst subsurface diffusion was found to limit the growth efficiency, and for excessively high underlayer annealing temperatures (>900 °C), catalyst coalescence/ripening led to the formation of double-wall carbon nanotubes. As a result, three distinct regions of synthesis were observed: (i) a "low yield" region below a threshold temperature (∼600 °C); (ii) an "increased yield" region from 600 to 900 °C, and (iii) a "saturation" region above 900 °C. The efficient SWCNT forest synthesis could only occur within a specific annealing temperature window as a result of this double-edged effects of underlayer annealing.

  13. The sword-shield strategy of the early 1960s

    International Nuclear Information System (INIS)

    Steinhoff, J.

    1994-01-01

    The sword and shield strategy of the post WWII German Federal Republic is discussed. The effort to rebuild the German air force following WWII is outlined. This effort was initiated in 1956 with material furnished by the US through the Nash Plan. The debate surrounding the validity of the sword-shield concept is described

  14. Edge stability and performance of the ELM-free quiescent H-mode and the quiescent double barrier mode on DIII-D

    International Nuclear Information System (INIS)

    West, W.P.; Burrell, K.H.; Snyder, P.B.; Gohil, P.; Lao, L.L.; Leonard, A.W.; Osborne, T.H.; Thomas, D.M.; Casper, T.A.; Lasnier, C.J.; Doyle, E.J.; Wang, G.; Zeng, L.; Nave, M.F.F.

    2005-01-01

    The quiescent H (QH) mode, an edge localized mode (ELM)-free, high-confinement mode, combines well with an internal transport barrier to form quiescent double barrier (QDB) stationary state, high performance plasmas. The QH-mode edge pedestal pressure is similar to that seen in ELMing phases of the same discharge, with similar global energy confinement. The pedestal density in early ELMing phases of strongly pumped counter injection discharges drops and a transition to QH-mode occurs, leading to lower calculated edge bootstrap current. Plasmas current ramp experiment and ELITE code modeling of edge stability suggest that QHmodes lie near an edge current stabilty boundary. At high triangularity, QH-mode discharges operate at higher pedestal density and pressure, and have achieved ITER level values of β PED and ν*. The QDB achieves performance of β N H 89 ∼ 7 in quasi-stationary conditions for a duration of 10 τ E , limited by hardware. Recently we demonstrated stationary state QDB discharges with little change in kinetic and q profiles (q 0 > 1) for 2 s, comparable to ELMing 'hybrid scenarios', yet without the debilitating effects of ELMs. Plasma profile control tools, including electron cyclotron heating and current drive and neutral beam heating, have been demonstrated to control simultaneously the q profile development, the density peaking, impurity accumulation and plasma beta. (author)

  15. The metallographic examination of sword no. 438 as part of a systematic survey of swords from the early medieval stronghold of Mikulčice, Czech Republic

    Directory of Open Access Journals (Sweden)

    Hošek, Jiří

    2012-12-01

    Full Text Available The paper deals with a metallographic examination of a sword from grave No. 438, which was uncovered at the site of Mikulčice (Hodonín county, a former early medieval stronghold in Moravia (Czech Republic. Mikulčice was one of the main power centres of the Great Moravia – the first state formed by Slavs north of the Danube River – which was created in the first third of the 9th century and ended at the beginning of the 10th century. The sword, provided with a single flattened hemispherical pommel (Petersen X type, has a blade bearing an inscription that is no longer legible. According to the results of metallographic examination, the blade was hardened and consists of steel cutting edges welded on a core, which was composed of steel side-plates and a middle strip of iron or low-carbon steel. It was an excellent sword, undoubtedly one of the best swords excavated in Mikulčice.

    El artículo trata de un examen metalográfico de una espada de la tumba número 438, que fue descubierta en el yacimiento de Mikulčice (Hodonín Condado, antiguo bastión bajomedieval en Moravia (República Checa. Mikulčice fue uno de los centros de poder principales del Gran Moravia - la primera agrupación estatal de los eslavos del norte del río Danubio - que se creó en el primer tercio del siglo IX y fue abolido al comienzo del siglo X. La espada, que cuenta con un pomo aplanado hemiesféri-co (Petersen tipo X, tiene una hoja con una inscripción que ya no es legible. De acuerdo con los resulta-dos del examen metalográfico, la hoja fue endurecida y se compone de filos de corte de acero, soldados a un núcleo. Éste está compuesto de placas laterales de acero y una franja central de hierro o de acero dulce. Era una espada excelente, sin duda, una de las mejores espadas jamás excavadas en Mikulčice.

  16. A Double-Edged Sword: Social Media as a Tool of Online Disinhibition Regarding American Sign Language and Deaf Cultural Experience Marginalization, and as a Tool of Cultural and Linguistic Exposure

    Directory of Open Access Journals (Sweden)

    K. Crom Saunders

    2016-01-01

    Full Text Available Social media has become a venue for social awareness and change through forum discussions and exchange of viewpoints and information. The rate at which awareness and cultural understanding regarding specific issues has not been quantified, but examining awareness about issues relevant to American Sign Language (ASL and American Deaf culture indicates that progress in increasing awareness and cultural understanding via social media faces greater friction and less progress compared to issues relevant to other causes and communities, such as feminism, the lesbian, gay, bisexual, and transgender (LGBT community, or people of color. The research included in this article examines online disinhibition, cyberbullying, and audism as it appears in the real world and online, advocacy for and against Deafness as a cultural identity, and a history of how Deaf people are represented in different forms of media, including social media. The research itself is also examined in terms of who conducts the research. The few incidents of social media serving the Deaf community in a more positive manner are also examined. This is to provide contrast to determine which factors may contribute to greater progress in fostering greater awareness of Deaf cultural issues without the seemingly constant presence of resistance and lack of empathy for the Deaf community’s perspectives on ASL and Deaf culture.

  17. 包容型领导对下属创造力的双刃剑效应%The Double-edged Sword Effect of Inclusive Leadership on Followers' Creativity

    Institute of Scientific and Technical Information of China (English)

    古银华; 卿涛; 杨付; 张征

    2017-01-01

    Innovation is increasingly becoming the motivation and source for enterprises' survival and development,therefore,more and more entrepreneurs claim: Innovation,or Death.However,the innovation of the enterprises has to rely on employee creativity.Therefore,how to improve the staff's creativity has become a hot topic in theory and practice of organizational management.As the key part and the soul of organizational management,the impact of leadership on employee creativity draws great attention naturally.This study will explore the relationship between inclusive leadership and subordinates' creativity.Inclusive leadership has two sides,namely the positive effect and negative effect.For testing whether inclusive leadership must be able to motivate the followers' creativity,based on the organizational support theory and the leadership-creativity model,this research,from two aspects of positive and negative effects,also explores the influence of inclusive leadership to followers' creativity.Based on 468 sets of leadership-subordinate matching questionnaire of 67 companies,the conclusions of this study are as follows: Inclusive leadership has a positive effect on followers' creativity.There is a significant multiple mediation effect of team psychological safety,followers' cognitive dependence and followers' motivation dependence in the action mechanism of inclusive leadership and followers' creativity.And the influence of inclusive leadership on followers' cognitive dependence and followers' motivation dependence has two different directions.This research expands the study of leadership style theory,leadership-creativity model theory,inclusive leadership theory and followers' creativity theory,and expands the relationship between inclusive leadership and organizational performance.Under the previous calls,we practice some new research methods.It proves that followers' dependence and inclusive leadership and their measuring tools are applicable under the context of Chinese culture.The innovation of this study is mainly manifested in the following three aspects: first of all,building the model of the influence mechanism of inclusive leadership to their followers'creativity;secondly,finding the key of the 'black box' to open the relationship between inclusive leadership and followers' creativity and revealing the transmission mechanism between inclusive leadership and followers' creativity;and finally,putting forward and verifying that the construct of followers' dependence can be divided into two dimensions of followers' cognitive dependence and followers' motivation dependence,and finding that followers' cognitive dependence and followers' motivation dependence will go in two different directions under the influence of inclusive leadership,which can promote the development of subordinate dependency theory.The study provides firms with theoretical reference and management enlightenment to create a harmonious security organization atmosphere and improve the creativity of employees.The practical significance of this study is: first of all,to provide new ways and new thinking pattern to enhance the creativity of the employees;secondly,to do a comparative study on the different impact paths of inclusive leadership to their followers;to provide scientific basis to improve the employees' creativity and finally to provide the basis of human resource management practice for selection of creative employees.%创新成为企业生存和发展的动力,而企业的创新要依赖于员工的创造力.因此,如何提高员工的创造力成为组织管理理论和实践的热门话题.领导者作为组织管理的关键和灵魂,领导风格对员工创造力的影响备受关注.然而,领导风格往往具有积极作用和消极作用的两面性.为验证包容型领导对下属创造力的双刃剑效应,基于组织支持理论和领导力-创造力模型,构建以团队心理安全感为促进机制和以下属依赖为抑制机制的并列多重中介模型,从正反两个视角探讨包容型领导对下属创造力的影响机制.通过对67家企业的468套上级-下属配对问卷调查,研究结果表明,①包容型领导对下属创造力的直接效应和总效应均为正向;②包容型领导与下属创造力之间,由团队心理安全感、下属认知依赖和下属动机依赖构成的多重中介作用显著;③团队心理安全感的中介效应为正向(前后两半段路径均为正向);④下属认知依赖的中介效应为负向(前半段路径为正向,后半段路径为负向);⑤下属动机依赖的中介效应为正向(前后两半段路径均为负向).研究结果验证了包容型领导对下属创造力的双刃剑效应,拓展了领导力-创造力模型和包容型领导理论,构建了包容型领导对下属创造力的影响机制模型,并找到了打开两者之间黑箱的钥匙,从多路径剖析包容型领导与下属创造力之间的传导机制,验证了下属依赖可分为下属认知依赖和下属动机依赖两个维度,并在综合前人观点的基础上对下属依赖、下属认知依赖和下属动机依赖的内涵进行界定.研究结论对营造和谐安全的组织氛围和提高员工创造力提供了理论参考和管理启示.

  18. Biologic meshes and synthetic meshes in cancer patients: a double-edged sword: differences in production of IL-6 and IL-12 caused by acellular dermal matrices in human immune cells.

    Science.gov (United States)

    Karsten, Maria Margarete; Enders, Sabine; Knabl, Julia; Kirn, Verena; Düwell, Peter; Rack, Brigitte; Blohmer, Jens-Uwe; Mayr, Doris; Dian, Darius

    2018-05-01

    In 2005, Breuing et al. first described the use of acellular dermal matrices (ADMs) in breast cancer patients. ADMs are assumed to be safe to use in an oncologic setting, but data from controlled studies are still needed. Here, we investigate the effects of ADMs on the production of interleukin (IL)-6 and IL-12, key regulators of immune suppression and activation. Strattice (ST), CollaMend (CM), and Biodesign (BD) biologic meshes and TiLoop, a synthetic mesh (TL), were used in this study. We isolated myeloid dendritic cells (MDCs), untouched plasmacytoid dendritic cells (pDCs), naïve B cells, and CD8+ T cells and co-cultured these cells with either the biologic meshes or TL. As positive controls, we used CpG ODN 2216 or lipopolysaccharide (LPS). The cytokine concentrations of IL-12p70 and IL-6 were determined after 7 days using sandwich ELISA sets. There were highly significant differences between the ADMs and TL in terms of their ability to stimulate immunologic responses. IL-6 expression was significantly increased in B cells (p = 0.0006131) and T cells (p = 0.00418) when comparing TL and ADMs. We also identified significant differences in IL-12 production by B cells (p = 0.0166) and T cells (p = 0.003636) when comparing TL and ADMs. Despite the assumed lack of an immunological response to ADMs, in our experimental study, human immune cells reacted with significantly different cytokine profiles. These findings may have implications for the potential activation or suppression of effector cells in cancer patients and could explain some of the post clinical post surgical signs of ADMS like skin rush and seroma.

  19. System Administration Support/SWORDS G2

    Science.gov (United States)

    Dito, Scott Joseph

    2014-01-01

    The Soldier-Warfighter Operationally Responsive Deployer for Space (SWORDS) rocket is a dedicated small satellite launcher that will minimize danger and complexity in order to allow soldiers in the field to put payloads of up to 25kg into orbit from the field. The SWORDSG2 project is the development of a model, simulation, and ultimately a working application that will control and monitor the cryogenic fluid delivery to the SWORDS rocket for testing purposes. To accomplish this, the project is using the programming language environment Gensym G2. The environment is an all-inclusive application that allows development, testing, modeling, and finally operation of the unique application through graphical and programmatic methods. In addition, observation of the current cryogenic fluid delivery system in the Kennedy Space Center Cry Lab has allowed me to gain valuable experience of fluid systems and propelant delivery that is valuable to our team when developing amd modeling our own system.The ultimate goal of having a test-ready application to show to the heads of the project, and demonstrating G2's capabilities, by late 2014 will require hard work and intense study and understanding of not only the programming aspect but also the physical phenomena we want to model, observe, and control.

  20. Swords into ploughshares: IDRC supports a new kind of peace ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-10-19

    Oct 19, 2010 ... Swords into ploughshares: IDRC supports a new kind of peace process ... The commission's substantive work is carried out by committees that deal with ... participants spoke under the Chatham House Rule, that is, in their ...

  1. Non-destructive bulk analysis of the Buggenum sword by neutron resonance capture analysis and neutron diffraction

    International Nuclear Information System (INIS)

    Postma, H.; Clarijs, M.; Borella, A.; Schillebeeckx, P.; Kamermans, H.

    2010-01-01

    Two neutron based techniques, neutron resonance capture analysis (NRCA) and time-of-flight neutron-diffraction (TOF-ND) have been used to determine the elemental composition and structure of a precious and very well preserved all-metal sword from the Bronze Age. This Buggenum sword was on loan from the National Museum of Antiquities (NMA) in Leiden (NL). NRCA and TOF-ND experiments have been carried out at a number of more or less identical positions of the sword. The tin-bronze ratio and the relative amounts of some minor elements (Sb, As, Ag, In) have been determined. The results of neutron diffraction measurements showed considerable tin-segregation, and clear indications of hardening on the edges of the blade. In addition, radiographs using Bremsstrahlung revealed the construction of the hilt-blade connection. The work was carried out at the EC Joint Research Centre IRMM in Geel (B) and at the ISIS facility of the Rutherford Appleton Laboratory (UK). (author)

  2. PNRI mutant variety: sansevieria 'Sword of Ibe'

    International Nuclear Information System (INIS)

    Aurigue, Fernando B.

    2011-01-01

    Sansevieria 'Sword of Ibe,' registered by the Philippine Nuclear Research Institute as NSIC 2008 Or-66, is a chlorophyll mutant of Sansevieria trifasciata 'Moonshine' developed by treating its suckers or shoots arising from a rhizome with acute gamma radiation from a Cobalt-60 source. The new mutant is identical in growth habit and vigor to Sansevieria 'Moonshine,' also known as Moonglow. Results of this mutation breeding experiment showed that leaf color and flowering were altered by gamma irradiation without changing the other characteristics of the plant. Propagation is true-to-type by separation of sucker and top cutting. The plant is recommended for use as landscaping material and as pot plant for indoor and outdoor use. The leaves may be harvested as cut foliage for Japanese flower arrangements. (author)

  3. The Metallurgy of some indian swords

    Directory of Open Access Journals (Sweden)

    Williams, Alan

    2007-12-01

    Full Text Available The metallurgy of Indian swords shows many differences from that of European swords. The distinction between "Damascus Steel" (or wootz and crucible steel is explained. Ten broken blades from the Armoury of the Nizams of Hyderabad were made available for microscopic examination. Six of these seem to been made from crucible steels, and are of notably high quality. By contrast, a group of six randomly collected from Private Collections in England were also examined. Only one of these was made of crucible steel, and three of the others were of very mediocre quality. This perhaps represents the quality of blades available to the average Indian soldier.

    La metalurgia de las espadas indias presenta notables diferencias en comparación con la de las europeas. Se explica la distinción entre el ‘acero de Damasco’ (o wootz y el acero de crisol. Se ha realizado un análisis microscópico de un conjunto de diez hojas rotas de espada depositadas en la Armería de los Nizams de Hyderabad. Seis de ellas parecen haber sido realizadas a partir de acero de crisol, y son de elevada calidad. En contraste, se examinó también un grupo de seis espadas de colecciones privadas en Inglaterra. Sólo una de ellas estaba fabricada con acero de crisol, y tres de las otras eran de calidad muy mediocre. Esto representa quizá la calidad de las hojas de espada al alcance del soldado medio indio.

  4. Double Wigner distribution function of a first-order optical system with a hard-edge aperture.

    Science.gov (United States)

    Pan, Weiqing

    2008-01-01

    The effect of an apertured optical system on Wigner distribution can be expressed as a superposition integral of the input Wigner distribution function and the double Wigner distribution function of the apertured optical system. By introducing a hard aperture function into a finite sum of complex Gaussian functions, the double Wigner distribution functions of a first-order optical system with a hard aperture outside and inside it are derived. As an example of application, the analytical expressions of the Wigner distribution for a Gaussian beam passing through a spatial filtering optical system with an internal hard aperture are obtained. The analytical results are also compared with the numerical integral results, and they show that the analytical results are proper and ascendant.

  5. Edward's sword? - A non-destructive study of a medieval king's sword

    Science.gov (United States)

    Segebade, Chr.

    2013-04-01

    Non-destructive and instrumental methods including photon activation analysis were applied in an examination of an ancient sword. It was tried to find indication of forgery or, if authentic, any later processing and alteration. Metal components of the hilt and the blade were analysed by instrumental photon activation. Non-destructive metallurgical studies (hardness measurements, microscopic microstructure analysis) are briefly described, too. The results of these investigations did not yield indication of non-authenticity. This stood in agreement with the results of stylistic and scientific studies by weapon experts.

  6. Szczerbiec (the jagged sword – the coronation sword of the kings of Poland

    Directory of Open Access Journals (Sweden)

    Biborski, Marcin

    2011-12-01

    Full Text Available The paper presents the results of newest research on the Szczerbiec – the Polish coronation sword. Technological examinations revealed that the blade was manufactured of bloomery steel, with C contents of c. 0.3-0.6 %. The blade was thermally treated (quenched and tempered in its part below the hilt. The X-ray revealed no pattern welding or composite structures. All this testifies to the authenticity of the sword as a genuine medieval weapon and not (as sometimes suggested in scholarship a 19th c. replica. The pommel and the crosspiece were made of silver and then coveted with nielloed gold plates. A combination of typological, stylistic and epigraphic data suggests a date of c. 1250 for the sword. As suggested by the lavishness of ornament and inscriptions of the all-metal hilt, as well as by the rectangular cross-section of the grip, the Szczerbiec may have been influenced by swords of the Mediterranean (especially Iberian cultural sphere. The swords of Sancho IV of Castille and Léon, of Santa Casilda, of Friedrich II von Hohenstaufen, of the Comtés de Dreux and a sword from the Museo Arqueológico Nacional in Madrid seem to be especially relevant analogies. Of particular significance is a Hebrew or Hebrew-Latin inscription on the crosspiece, which fits into a tradition of Hebrew-inspired voces magicae. The first owner of the sword was in all probability Boles?aw Pobo?ny (the Pious, Duke of Great Poland (died 1279. For Duke Boles?aw the sword was his gladius iustitiae and a protective talisman. The weapon was then inherited (probably through marriage to his daughter Jadwiga c. 1293 by Duke Bolesław Pobożny (the Short or the Ell-high (the future King of Poland. It was in all probability Duke Vladislao Łokietek who first used the sword as a coronation insignia.

    Este trabajo presenta los últimos resultados de la investigación sobre la Szczerbiec – la espada de coronación polaca. El examen tecnológico revela que la espada se

  7. Quantification of toy sword kinematics with male pediatric volunteers.

    Science.gov (United States)

    Beeman, Stephanie M; Rowson, Steven; Duma, Stefan M

    2014-01-01

    While extensive research in toy safety has been performed, data is unavailable with regard to the kinematics of toy swords. To improve upon design criteria, knowledge of a child’s physical capacity is essential. The purpose of this study was to quantify the linear and angular velocities generated by children swinging toy swords. A total of 36 male subjects, ages 4-14 years old, each participated in one trial. Subjects were instructed to swing a toy sword as fast and hard as possible for ~10 seconds. A Vicon motion analysis system was used to capture subject and sword kinematics. Peak linear and angular sword velocities were calculated. A strong correlation was identified between age and velocity. The 8-14 year old males were not significantly different. The 4 year old males generated significantly lower velocities than the 8-14 year old males. The 6 year old males produced significantly lower velocities than the 10- 14 year old males. It was concluded that age had a significant effect on the linear and angular velocities generated by children. The trends observed within this study likely result from typical pediatric and adolescent development. By accounting for the physical capabilities of a specific population, toys can be designed with decreased inherent risks of injury.

  8. Exponential Increase in Relative Biological Effectiveness Along Distal Edge of a Proton Bragg Peak as Measured by Deoxyribonucleic Acid Double-Strand Breaks

    Energy Technology Data Exchange (ETDEWEB)

    Cuaron, John J., E-mail: cuaronj@mskcc.org [Memorial Sloan Kettering Cancer Center, New York, New York (United States); Chang, Chang [Texas Center for Proton Therapy, Irving, Texas (United States); Lovelock, Michael; Higginson, Daniel S. [Memorial Sloan Kettering Cancer Center, New York, New York (United States); Mah, Dennis [Procure Proton Therapy Center, Somerset, New Jersey (United States); Cahlon, Oren; Powell, Simon [Memorial Sloan Kettering Cancer Center, New York, New York (United States)

    2016-05-01

    Purpose: To quantify the relative biological effectiveness (RBE) of the distal edge of the proton Bragg peak, using an in vitro assay of DNA double-strand breaks (DSBs). Methods and Materials: U2OS cells were irradiated within the plateau of a spread-out Bragg peak and at each millimeter position along the distal edge using a custom slide holder, allowing for simultaneous measurement of physical dose. A reference radiation signal was generated using photons. The DNA DSBs at 3 hours (to assess for early damage) and at 24 hours (to assess for residual damage and repair) after irradiation were measured using the γH2AX assay and quantified via flow cytometry. Results were confirmed with clonogenic survival assays. A detailed map of the RBE as a function of depth along the Bragg peak was generated using γH2AX measurements as a biological endpoint. Results: At 3 hours after irradiation, DNA DSBs were higher with protons at every point along the distal edge compared with samples irradiated with photons to similar doses. This effect was even more pronounced after 24 hours, indicating that the impact of DNA repair is less after proton irradiation relative to photons. The RBE demonstrated an exponential increase as a function of depth and was measured to be as high as 4.0 after 3 hours and as high as 6.0 after 24 hours. When the RBE-corrected dose was plotted as a function of depth, the peak effective dose was extended 2-3 mm beyond what would be expected with physical measurement. Conclusions: We generated a highly comprehensive map of the RBE of the distal edge of the Bragg peak, using a direct assay of DNA DSBs in vitro. Our data show that the RBE of the distal edge increases with depth and is significantly higher than previously reported estimates.

  9. Archaeometric study of a bronze age sword discovered at Giurgiu, Romania

    International Nuclear Information System (INIS)

    Olariu, Agata; Badica, Teodor; Alexandrescu, Emilian; Avram, Alexandru

    2008-01-01

    The compositional scheme of a Bronze Age sword, found near the town of Giurgiu in Romania has been determined by the method of particle-induced X-ray emission (PIXE). The elemental composition of the sword was compared with the composition of other swords from the same geographic area, the Danubian plain from Bulgaria, and Transylvania regions. Both the physical analyzes and the archaeological considerations show that the sword from Giurgiu could be associated with the swords from Bulgaria, having compositional, stylistic, temporal and geographical similitudes. (authors)

  10. "1"4C ages and calendar years of Japanese swords measured with accelerator mass spectrometry

    International Nuclear Information System (INIS)

    Nagata, Kazuhiro; Matsubara, Akihiro; Kokubu, Yoko; Nakamura, Toshio

    2016-01-01

    Steel of Japanese swords has been produced with Tatara process from iron sand and charcoal. Carbon dissolved in steel was absorbed from wooden charcoal fuel during the production of the steel. From the decay of "1"4C activity in the steel, the "1"4C age of Japanese sword can be determined. The "1"4C ages of 4 Japanese swords were measured with accelerator mass spectrometry and calibrated to calendar years. Each "1"4C age provided plural calendar year periods with definite probabilities, and one of the periods agreed with the production year of each sword that was determined from the sword master's name cut in the grip of his sword after taking the age range of charcoal used for steel production and usage for several generations of the same names of sword masters into account. (author)

  11. Application of neutron radiography to restoration of an excavated sword

    International Nuclear Information System (INIS)

    Masuzawa, Fumitake; Murata, Tadashige; Ozaki, Makoto

    1992-01-01

    An excavated sword had turned to fragments of corrosion covered with grit and rust. There are two holes at the pommel and the guard which have elaborate inner walls. The original sword must have had the pommel and the guard, whose shapes had been the same as those of the holes. What were materials of them? Why have they disappeared to have changed into holes? No key which answers these questions has been gotten with macrography and X-ray radiography. Then neutron radiography was tried to examine that. Images which were not recognized on X-ray radiographs appeared on neutron ones. Above-mentioned questions were solved by investigation of them. This paper describes that the sword were well conserved and restored on the basis of it. (author)

  12. Two swords from the foundation of Gibraltar

    Directory of Open Access Journals (Sweden)

    Nicolle, David

    2002-12-01

    Full Text Available The two swords plus their associated acabbard and belt or baldric fragments which were found in Matin’s Cave, Gibraltar, date from the 12th century AD. Such dating is supporting the design to the objects themselves, their cultural-historical context, and their varied decoration. This evidence is also used to propose that the ensemble was all of Andalusian of North African origin, and as such represents an almost unique survival of 12th century western Islamic military equipment.

    Las dos espadas, junto con sus correspondientes vainas y restos de cinto o tahalí, halladas en Martin’s Cave (Gibraltar, deben fecharse en el siglo XII d.C. Esta datación se basa en la tipología de los objetos, en su contexto histórico-cultural, y en su variada decoración. Estos datos se emplean también para proponer que el conjunto es de origen Andalusí o Norteafricano, y que por tanto representan un caso casi único de preservación de equipo militar islámico occidental del s. XII.

  13. Realtime synthesized sword-sounds in Wii computer games

    DEFF Research Database (Denmark)

    Böttcher, Niels

    This paper presents the current work carried out on an interactive sword fighting game, developed for the Wii controller. The aim of the work is to develop highly interactive action-sound, which is closely mapped to the physical actions of the player. The interactive sword sound is developed using...... a combination of granular synthesis and subtractive synthesis simulating wind. The aim of the work is to test if more interactive sound can affect the way humans interact physically with their body, when playing games with controllers such as the Wii remote....

  14. SWORDS: A statistical tool for analysing large DNA sequences

    Indian Academy of Sciences (India)

    Unknown

    These techniques are based on frequency distributions of DNA words in a large sequence, and have been packaged into a software called SWORDS. Using sequences available in ... tions with the cellular processes like recombination, replication .... in DNA sequences using certain specific probability laws. (Pevzner et al ...

  15. Covenants with Weak Swords: ISO 14001 and Facilities' Environmental Performance

    Science.gov (United States)

    Potoski, Matthew; Prakash, Aseem

    2005-01-01

    Voluntary environmental programs are codes of progressive environmental conduct that firms pledge to adopt. This paper investigates whether ISO 14001, a voluntary program with a weak sword--a weak monitoring and sanctioning mechanism--can mitigate shirking and improve participants' environmental performance. Sponsored by the International…

  16. A note on the analysis of Viking swords

    Directory of Open Access Journals (Sweden)

    Williams, Alan

    2011-12-01

    Full Text Available A large number of swords from the Viking era bear the inscription «VLFBERHT» or a variation on that. The metallurgy of different examples of these swords varies considerably but the metal employed correlates with the spelling of that name. In seeking to determine the origin of these swords, metallurgical studies may guide us, especially as many of the best examples differ considerably from both earlier and later Medieval swords.

    Un número importante de espadas de época vikinga llevan la inscripción «VLFBERHT» o una variante de la misma. La metalurgia de diferentes ejemplos de dichas espadas varía considerablemente, pero el metal empleado guarda correlación con la forma en que se escribió dicho nombre. Cuando tratamos de determinar el origen de estas espadas, los estudios metalúrgicos pueden servirnos de guía, especialmente dado que muchos de los mejores ejemplos difieren considerablemente de espadas medievales tanto anteriores como posteriores en el tiempo.

  17. Hypereutectoid steel in early medieval sword production in Europe

    Czech Academy of Sciences Publication Activity Database

    Kucypera, P.; Hošek, Jiří

    2014-01-01

    Roč. 27, [1] (2014), s. 31-39 ISSN 0860-0007 R&D Projects: GA ČR GAP405/12/2289 Institutional support: RVO:67985912 Keywords : swords * Early Middle Ages * hypereutectoid steel Subject RIV: AC - Archeology, Anthropology, Ethnology

  18. Characterization of an Indian sword: classic and noninvasive methods of investigation in comparison

    Science.gov (United States)

    Barzagli, E.; Grazzi, F.; Williams, A.; Edge, D.; Scherillo, A.; Kelleher, J.; Zoppi, M.

    2015-04-01

    The evolution of metallurgy in history is one of the most interesting topics in Archaeometry. The production of steel and its forging methods to make tools and weapons are topics of great interest in the field of the history of metallurgy. In the production of weapons, we find almost always the highest level of technology. These were generally produced by skilled craftsmen who used the best quality materials available. Indian swords are an outstanding example in this field and one of the most interesting classes of objects for the study of the evolution of metallurgy. This work presents the study of a Shamsheer (a sword with a curved blade with single edge) made available by the Wallace Collection in London. The purpose of this study was to determine the composition, the microstructure, the level and the direction of residual strain and their distribution in the blade. We have used two different approaches: the classical one (metallography) and a nondestructive technique (neutron diffraction): In this way, we can test differences and complementarities of these two techniques. To obtain a good characterization of artifacts studied by traditional analytical methods, an invasive approach is required. However, the most ancient objects are scarce in number, and the most interesting ones are usually in an excellent state of conservation, so it is unthinkable to apply techniques with a destructive approach. The analysis of blades that has been performed by metallographic microscopy has demonstrated the specificity of the production of this type of steel. However, metallographic analysis can give only limited information about the structural characteristics of these artifacts of high quality, and it is limited to the sampled areas. The best approach for nondestructive analysis is therefore to use neutron techniques.

  19. A study of essential elements in ancient Thai fighting swords by chemical and nuclear techniques

    International Nuclear Information System (INIS)

    Janposri, K.

    1980-01-01

    Four ancient Thai fighting swords from the Bangkok National Museum and iron ore from Kao Tab Kwai, Lopburi were studied by neutron activation analysis, metallography and chemical analysis. The results of these scientific studies show that all of these four swords are made of plain carbon steel, containing trace elements which have no effect on the physical and mechanical properties of the steel. The trace elements which were found in the iron ore are quite similar to those found in one of these swords. This means that the iron in one of the swords may have come from ore found at Kao Tab Kwai, Lopburi

  20. Simulating Terrestrial Gamma-ray Flashes using SWORD (Invited)

    Science.gov (United States)

    Gwon, C.; Grove, J.; Dwyer, J. R.; Mattson, K.; Polaski, D.; Jackson, L.

    2013-12-01

    We report on simulations of the relativistic feedback discharges involved with the production of terrestrial gamma-ray flashes (TGFs). The simulations were conducted using Geant4 using the SoftWare for the Optimization of Radiation Detectors (SWORD) framework. SWORD provides a graphical interface for setting up simulations in select high-energy radiation transport engines. Using Geant4, we determine avalanche length, the energy spectrum of the electrons and gamma-rays as they leave the field region, and the feedback factor describing the degree to which the production of energetic particles is self-sustaining. We validate our simulations against previous work in order to determine the reliability of our results. This work is funded by the Office of Naval Research.

  1. Two medieval swords from the regional museum in Jagodina

    Directory of Open Access Journals (Sweden)

    Cvetković Branislav

    2009-01-01

    Full Text Available The author analyzes two medieval swords (one found near Kalenić monastery and one near the Ćuprija town from the funds of the Department of Archaeology in the Regional Museum in Jagodina. He presents arguments in opposition to the typological classification existent in scholarly literature of the first one, and concludes that the both specimens most probably originate from the same workshop, as were being stamped with identical maker-marks. In the end the author draws one’s attention to circumstances of the site find of the first sword, and also points towards possible directions of research of the sacred topography of the Kalenić monastery environs.

  2. Casting Simulation of an Austrian Bronze Age Sword Hilt

    Science.gov (United States)

    Pola, Annalisa; Mödlinger, Marianne; Piccardo, Paolo; Montesano, Lorenzo

    2015-07-01

    Bronze Age swords with a metal hilt can be considered the peak of Bronze Age casting technologies. To reconstruct the casting techniques used more than 3000 years ago, a metal hilted sword of the Schalenknauf type from Lower Austria was studied with the aid of macroscopic analyses and simulation of mold filling and casting solidification. A three-dimensional model of the hilt was created based on optical scanner measurements performed on a hilt recently discovered during archaeological excavations. Three different configurations of the gating system were considered, two on the pommel disk and one on the knob, and the effect of its location on the formation of casting defects was investigated. Three-dimensional computed tomography was used to detect internal defects, such as gas and shrinkage porosity, which were then compared with those calculated by simulation. The best match between actual and predicted hilt quality demonstrated the location of the gating system, which turned out to be on the pommel disk.

  3. Regulatory role of NKG2D+ NK cells in intestinal lamina propria by secreting double-edged Th1 cytokines in ulcerative colitis.

    Science.gov (United States)

    Wang, Fan; Peng, Pai-Lan; Lin, Xue; Chang, Ying; Liu, Jing; Zhou, Rui; Nie, Jia-Yan; Dong, Wei-Guo; Zhao, Qiu; Li, Jin

    2017-11-17

    The role of intestinal lamina propria (LP) NKG2D+ NK cells is unclear in regulating Th1/Th2 balance in ulcerative colitis (UC). In this study, we investigated the frequency of LP NKG2D+ NK cells in DSS-induced colitis model and intestinal mucosal samples of UC patients, as well as the secretion of Th1/Th2/Th17 cytokines in NK cell lines after MICA stimulation. The role of Th1 cytokines in UC was validated by bioinformatics analysis. We found that DSS-induced colitis in mice was characterized by a Th2-mediated process. In acute phrase, the frequency of LP NKG2D+ lymphocytes increased significantly and decreased in remission, while the frequency of LP NKG2D+ NK cells decreased significantly in acute phase and increased in remission. No obvious change was found in the frequency of total LP NK cells. Similarly, severe UC patients had a higher expression of mucosal NKG2D and a lower number of NKG2D+ NK cells than mild to moderate UC. In NK cell lines, the MICA stimulation could induce a predominant secretion of Th1 cytokines (TNF, IFN-γ). Furthermore, in bioinformatics analysis, mucosal Th1 cytokine of TNF, showed a double-edged role in UC when compared to the Th1-mediated disease of Crohn's colitis. In conclusion, LP NKG2D+ NK cells partially played a regulatory role in UC through secreting Th1 cytokines to regulate the Th2-predominant Th1/Th2 imbalance, despite of the concomitant pro-inflammatory effects of Th1 cytokines.

  4. Comparing signal intensity and refraction sensitivity of double and single mask edge illumination lab-based x-ray phase contrast imaging set-ups

    International Nuclear Information System (INIS)

    Kallon, G K; Diemoz, P C; Vittoria, F A; Basta, D; Endrizzi, M; Olivo, A

    2017-01-01

    Double mask edge illumination (DM-EI) set-ups can detect differential phase and attenuation information from a sample. However, analytical separation of the two signals often requires acquiring two frames with inverted differential phase contrast signals. Typically, between these two acquisitions, the first mask is moved to create a different illumination condition. This can lead to potential errors which adversely affect the data collected. In this paper, we implement a single mask EI laboratory set-up that allows for a single shot retrieval of the differential phase and attenuation images, without the need for a high resolution detector or high magnification. As well as simplifying mask alignment, the advantages of the proposed set-up can be exploited in one of two ways: either the total acquisition time can be halved with respect to the DM-EI set-up or, for the same acquisition time, twice the statistics can be collected. In this latter configuration, the signal-to-noise ratio and contrast in the mixed intensity images, and the angular sensitivity of the two set-ups were compared. We also show that the angular sensitivity of the single mask set-up can be well approximated from its illumination curve, which has been modelled as a convolution between the source spatial distribution at the detector plane, the pre-sample mask and the detector point spread function (PSF). A polychromatic wave optics simulation was developed on these bases and benchmarked against experimental data. It can also be used to predict the angular sensitivity and contrast of any set-up as a function of detector PSF. (paper)

  5. Swords and sabers during the Early Islamic Period

    Directory of Open Access Journals (Sweden)

    Alexander, David

    2001-12-01

    Full Text Available The present article offers a discussion on early swords and sabers during the Early Islamic Period, from the Topkap’ Sarayi collection to written, iconographic and archeological sources.

    El presente art’culo trata las espadas y sables utilizados en los primeros tiempos del Islam a partir de la colecció—n del Topkap’ Sarayi y de las fuentes escritas, iconogr‡ficas y arqueol—gicas.

  6. Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a ‘Double Edged Sword’

    Science.gov (United States)

    McLachlan, Sandra M.; Aliesky, Holly A.; Chen, Chun-Rong; Chong, Gao; Rapoport, Basil

    2012-01-01

    Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before immunization with adenovirus encoding the A-subunit (A-sub-Ad) breaks tolerance, inducing extensive thyroid lymphocytic infiltration, thyroid damage and antibody spreading to other thyroid proteins. In contrast, no thyroiditis develops in Hi-expressor transgenics or wild-type mice. Our present goal was to determine if thyroiditis could be induced in Hi-expressor transgenics using a more potent immunization protocol: Treg depletion, priming with Complete Freund's Adjuvant (CFA) + A-subunit protein and further Treg depletions before two boosts with A-sub-Ad. As controls, anti-CD25 treated Hi- and Lo-expressors and wild-type mice were primed with CFA+ mouse thyroglobulin (Tg) or CFA alone before A-sub-Ad boosting. Thyroiditis developed after CFA+A-subunit protein or Tg and A-sub-Ad boosting in Lo-expressor transgenics but Hi- expressors (and wild-type mice) were resistant to thyroiditis induction. Importantly, in Lo-expressors, thyroiditis was associated with the development of antibodies to the mouse TSHR downstream of the A-subunit. Unexpectedly, we observed that the effect of bacterial products on the immune system is a “double-edged sword”. On the one hand, priming with CFA (mycobacteria emulsified in oil) plus A-subunit protein broke tolerance to the A-subunit in Hi-expressor transgenics leading to high TSHR antibody levels. On the other hand, prior treatment with CFA in the absence of A-subunit protein inhibited responses to subsequent immunization with A-sub-Ad. Consequently, adjuvant activity arising in vivo after bacterial infections combined with a protein autoantigen can break self-tolerance but in the absence of the autoantigen, adjuvant activity can inhibit the induction of immunity to autoantigens (like the

  7. Influence of the distribution of nitrides in the hardness of ancient swords

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Hellen C.; Added, Nemitala; Fantini, Marcia C.A. [Universidade de Sao Paulo (DFN/IF/USP), SP (Brazil). Inst. de Fisica. Dept. de Fisica Nuclear

    2010-07-01

    The aim of this work is correlate the depth profile of nitrogen in the blade of ancient swords with their hardness, and specifies the composition of steel alloy. The depth profile of nitrogen will be obtained using the resonances in production of {gamma} rays (4.43 MeV) for the reaction {sup 15}N(p, {alpha}{gamma}){sup 12}C. The samples (a Hindu sword, a Japanese sword and standard samples) will be also characterized using the technique PIXE to identify the concentration of major elements and trace elements of the steel alloy used in the manufacturing of each ancient sword. In order to evaluate other influences, we will perform crystallographic investigations using XRD to identify the crystalline surface phase, as well as radiograph the pieces using X-ray to check how the internal structure of the each sword grip is. The work will be executed in collaboration with the researcher Diogo Emiliano who will supply the swords. This study adds to archaeometry a method to evaluate ductility and hardness among swords from different culture and ages. (author)

  8. Influence of the distribution of nitrides in the hardness of ancient swords

    International Nuclear Information System (INIS)

    Santos, Hellen C.; Added, Nemitala; Fantini, Marcia C.A.

    2010-01-01

    The aim of this work is correlate the depth profile of nitrogen in the blade of ancient swords with their hardness, and specifies the composition of steel alloy. The depth profile of nitrogen will be obtained using the resonances in production of γ rays (4.43 MeV) for the reaction 15 N(p, αγ) 12 C. The samples (a Hindu sword, a Japanese sword and standard samples) will be also characterized using the technique PIXE to identify the concentration of major elements and trace elements of the steel alloy used in the manufacturing of each ancient sword. In order to evaluate other influences, we will perform crystallographic investigations using XRD to identify the crystalline surface phase, as well as radiograph the pieces using X-ray to check how the internal structure of the each sword grip is. The work will be executed in collaboration with the researcher Diogo Emiliano who will supply the swords. This study adds to archaeometry a method to evaluate ductility and hardness among swords from different culture and ages. (author)

  9. Two incrusted medieval swords from Zbaszyn, Lubusz voivodship

    Directory of Open Access Journals (Sweden)

    Głosek, Marian

    2007-12-01

    Full Text Available This paper presents two interesting medieval swords that can be dated between the end of the 12th century to the beginning of the 14th century AD. Both display, engraved in the fuller, inscriptions in silver and copper inlay, one of them a Latin text, the other heraldic symbols.

    Se presentan dos espadas medievales fechables entre finales del S. XII y principios del XIV, decoradas con damasquinados en plata y aleación de cobre. Una presenta un texto latino y mativos ornamentales; la otra, elementos heráldicos.

  10. Investigation of a medieval sword using photon activation analysis

    International Nuclear Information System (INIS)

    Segebade, Chr.

    1993-01-01

    An ancient sword was examined for indications of forgery or, if authentic, any later processing or changes, e.g. replacement of parts of the weapon. Radiochemical as well as non-destructive analyses using high energy photon activation were used as analytical techniques. Metal parts of the hilt were analysed radiochemically and instrumentally whereas the blade was analysed non-destructively. Metallurgical investigations (hardness measurements, microstructure analysis) performed in parallel are also briefly described. No evidence of non-authenticity was found, which agrees well with the results of stylistical and weapon-scientific investigation carried out by an expert of ancient weaponry. (author) 20 refs.; 1 fig.; 2 tabs

  11. An Archaeometallurgical Investigation of a Steel Sword from the Safavid Dynasty

    Science.gov (United States)

    Dini, Ghasem

    2018-02-01

    In this study, a steel sword belonging to the Safavid dynasty was investigated to identify its chemistry, microstructure, mechanical properties, and processing. To this aim, chemical and phase analyses, optical microscopy investigations and a hardness test were conducted. The results indicated that the sword blade material was plain carbon steel containing 1.42 wt.% C. The microstructure consisted of spheroidal cementite particles in a ferrite matrix, facilitating the formation of a curved sword. It seemed that a combination of heat treatment and metal-forming techniques (thermo-mechanical process) was utilized to obtain this microstructure.

  12. Edward’s sword? – A non-destructive study of a medieval king’s sword

    International Nuclear Information System (INIS)

    Segebade, Chr.

    2013-01-01

    Non-destructive and instrumental methods including photon activation analysis were applied in an examination of an ancient sword. It was tried to find indication of forgery or, if authentic, any later processing and alteration. Metal components of the hilt and the blade were analysed by instrumental photon activation. Non-destructive metallurgical studies (hardness measurements, microscopic microstructure analysis) are briefly described, too. The results of these investigations did not yield indication of non-authenticity. This stood in agreement with the results of stylistic and scientific studies by weapon experts.

  13. Edward's sword? - A non-destructive study of a medieval king's sword

    Energy Technology Data Exchange (ETDEWEB)

    Segebade, Chr. [Idaho Accelerator Centre, Idaho State University, 1500 Alvin Ricken Drive, Pocatello, ID 83201 (United States)

    2013-04-19

    Non-destructive and instrumental methods including photon activation analysis were applied in an examination of an ancient sword. It was tried to find indication of forgery or, if authentic, any later processing and alteration. Metal components of the hilt and the blade were analysed by instrumental photon activation. Non-destructive metallurgical studies (hardness measurements, microscopic microstructure analysis) are briefly described, too. The results of these investigations did not yield indication of non-authenticity. This stood in agreement with the results of stylistic and scientific studies by weapon experts.

  14. External-RBS, PIXE and NRA analysis for ancient swords

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Hellen C., E-mail: hellencsa@gmail.com; Added, Nemitala; Silva, Tiago F.; Rodrigues, C.L.

    2015-02-15

    Elemental composition of the steel of two ancient swords (Japanese and Damascus from a private collection) was characterized using in air IBA techniques. Our results contribute for the understanding the processes of manufacturing (hammering and quenching) and surface treatments applied in these swords. The Particle Induced X-ray Emission (PIXE) measurements along the Damascus blade allowed to identify and to trace a superficial concentration profile for the elements such Cr, Mn, Fe, Ni, Cu, Zn and As, while results for the Japanese blade showed only the presence of iron. The carbon content on the surface was also investigated using a resonant region in the Elastic Backscattering Spectrometry (EBS) measurements and the results have shown a slightly difference between the surfaces under investigation. In order to investigate the nitrogen content on surface, that could explain the hardening process, we used Nuclear Reaction Analysis (NRA) and the results shown that nitrogen content was under our detection limit for the technique (0.3% in mass). The measurements of PIXE, NRA and EBS were taken using the external beam setup installed at Lamfi – São Paulo/Brazil, the latter being successfully implemented for the first time in this facility.

  15. External-RBS, PIXE and NRA analysis for ancient swords

    Science.gov (United States)

    Santos, Hellen C.; Added, Nemitala; Silva, Tiago F.; Rodrigues, C. L.

    2015-02-01

    Elemental composition of the steel of two ancient swords (Japanese and Damascus from a private collection) was characterized using in air IBA techniques. Our results contribute for the understanding the processes of manufacturing (hammering and quenching) and surface treatments applied in these swords. The Particle Induced X-ray Emission (PIXE) measurements along the Damascus blade allowed to identify and to trace a superficial concentration profile for the elements such Cr, Mn, Fe, Ni, Cu, Zn and As, while results for the Japanese blade showed only the presence of iron. The carbon content on the surface was also investigated using a resonant region in the Elastic Backscattering Spectrometry (EBS) measurements and the results have shown a slightly difference between the surfaces under investigation. In order to investigate the nitrogen content on surface, that could explain the hardening process, we used Nuclear Reaction Analysis (NRA) and the results shown that nitrogen content was under our detection limit for the technique (0.3% in mass). The measurements of PIXE, NRA and EBS were taken using the external beam setup installed at Lamfi - São Paulo/Brazil, the latter being successfully implemented for the first time in this facility.

  16. External-RBS, PIXE and NRA analysis for ancient swords

    International Nuclear Information System (INIS)

    Santos, Hellen C.; Added, Nemitala; Silva, Tiago F.; Rodrigues, C.L.

    2015-01-01

    Elemental composition of the steel of two ancient swords (Japanese and Damascus from a private collection) was characterized using in air IBA techniques. Our results contribute for the understanding the processes of manufacturing (hammering and quenching) and surface treatments applied in these swords. The Particle Induced X-ray Emission (PIXE) measurements along the Damascus blade allowed to identify and to trace a superficial concentration profile for the elements such Cr, Mn, Fe, Ni, Cu, Zn and As, while results for the Japanese blade showed only the presence of iron. The carbon content on the surface was also investigated using a resonant region in the Elastic Backscattering Spectrometry (EBS) measurements and the results have shown a slightly difference between the surfaces under investigation. In order to investigate the nitrogen content on surface, that could explain the hardening process, we used Nuclear Reaction Analysis (NRA) and the results shown that nitrogen content was under our detection limit for the technique (0.3% in mass). The measurements of PIXE, NRA and EBS were taken using the external beam setup installed at Lamfi – São Paulo/Brazil, the latter being successfully implemented for the first time in this facility

  17. Automatic creation of simulation configuration. The SIPA workshop: SWORD

    International Nuclear Information System (INIS)

    Oudot, G.; Valembois, A.

    1994-01-01

    SWORD (Software Workshop Oriented towards Research and Development) is not only a software management system but also and mainly a software development system. The SWORD workshop is organised in hierarchical levels: (1) the automatic or manual creation of elementary models based on FORTRAN ANSI standard language; these models have interface variables structured in so-called connection points; Automatic model generators are used for the simulation of standard, repeated equipment: HYTHERNET covers the simulation of hydraulic, thermal, chemistry and activity; CONTRONET covers the simulation of I and C system, i.e. logic, protection and control systems; The capture of system topology for both generators is carried out on a graphic workstation under CAD system, (2) The models assembly generator, in charge of linking models (via connection points) and organizing their calling sequence in order to create a simulation application, (3) The configurations in charge of creation of external environment and of links between models assembly and external environment (connection with control desk, plant computer system, safety parameter display etc.), (4) The configuration generator which exports the simulation configuration to the target machine and generates the appropriate command for compilations and link editions; The workshop Administration ensures management, consistency checks are carried out at each step with warnings generated when applicable, and automatic chaining of the appropriate commands according to engineer request are available. (orig.) (4 refs., 4 figs.)

  18. Role of Duplex Doppler US for Thyroid Nodules: Looking for the 'Sword' Sign

    International Nuclear Information System (INIS)

    Lacout, Alexis; Marcy, Pierre Yves; Thariat, Juliette

    2011-01-01

    Duplex Doppler US may be useful for the detection of thyroid malignancies that show either anarchic winding or penetrating 'sword like' neoangiogenic vessels. It may be helpful in selecting nodules that should undergo fine needle aspiration biopsy.

  19. The iron swords from the necropolis of Son Pellisser; preliminary advance

    Directory of Open Access Journals (Sweden)

    Agustín Fernández Mártinez

    2016-11-01

    Full Text Available This paper submits the iron swords from the necropolis of Son Pellisser (Calvià-Majorca. Although the materials that we find are numerous and still under research offer a preliminary study about three imported swords, found in burial objects, also their possible origin and way of introduction on the island. These weapons could be the first archaeological evidence that the Balearic mercenaries participated in the Wars of Sicily, between Carthaginians and Greeks, from the fifth century BC.

  20. A comparison of antioxidative and anti-inflammatory activities of sword beans and soybeans fermented with Bacillus subtilis.

    Science.gov (United States)

    Han, Seon Su; Hur, Sun Jin; Lee, Si Kyung

    2015-08-01

    This study was conducted to determine the antioxidative and anti-inflammatory activities of non-fermented or Bacillus subtilis-fermented soybeans and sword beans (red and white). The total flavonoid content in both sword bean types was higher (1.9-2.5-fold) than that in soybeans. The total phenolic content in fermented red sword beans was 2.5-fold greater than that in non-fermented red sword beans. HPLC profiles revealed that gallic acid, methyl gallate, and ellagic acid were major phenolic components of non-fermented/fermented red sword beans. DPPH radical scavenging activity and ferric-reducing antioxidant power were higher in fermented red sword beans than in other beans. Non-fermented/fermented red sword beans had higher nitrite scavenging activity than butylated hydroxytoluene and non-fermented/fermented soybeans. The hyaluronidase inhibitory activity of non-fermented/fermented red sword beans was higher (1.5-2.6-fold) than that of non-fermented/fermented soybeans. These results suggest that B. subtilis-fermented sword beans are potential natural antioxidant sources and anti-inflammatory agents for the food industry.

  1. The Two Edged Sword; Illinois' Risk Reduction Success Through Managed Retreat And Strong Regulations

    Science.gov (United States)

    Osman, P.

    2017-12-01

    Illinois has the nation's largest inland system of rivers, lakes, and streams. Two thirds of the continental US and two Canadian provinces drain thru Illinois. Although a blessing, these waterways also result in frequent flooding. Historically, Illinois ranked among the top five states in the nation for flood losses. However, using a combination of strong floodplain regulations and proactive flood mitigation programs, Illinois now ranks near the bottom of flood loss states. Following the 1993 flood, the State of Illinois began an aggressive program to remove flood prone structures from the floodplain. Using a combination of state, federal, and local funds, towns like Valmeyer and Grafton have largely been relocated outside of the floodplain. Likewise, in dozens of communities across the state, thousands of structures have been have purchased to create open space in the floodplain. In addition, new structures in the floodplain must meet strict state and local floodplain construction standards. Major floods now routinely pass Illinois unnoticed. Many communities once ravaged by flooding now pass large floods unscathed. Due largely to climate change, flood losses in many areas are evolving. The majority of flood losses in Illinois now occur outside of the mapped floodplain. The State of Illinois has recently completed a detailed analysis of the state's urban flood exposure. Flood risk is changing and methods to address that risk must evolve accordingly. Accurate climate change data on major inland waterways and urban areas remain elusive. This presentation will highlight simple steps any state or community can take to reduce existing flood losses and be better prepared to address changing impacts due to climate change.

  2. [Alcohol intake--a two-edged sword. Part 1: metabolism and pathogenic effects of alcohol].

    Science.gov (United States)

    Ströhle, Alexander; Wolters, Maike; Hahn, Andreas

    2012-08-01

    From the biomedical point of view alcohol is a Janus-faced dietary component with a dose-dependent effect varying from cardiovascular protection to cytotoxicity. Alcohol is absorbed in the upper gastrointestinal tract by passive diffusion, is quickly distributed throughout body water and is mostly eliminated through oxidation. The enzymatically-catalyzed oxidative degradation to acetaldehyde and further to acetate is primarily localized in the liver. In case of a low blood alcohol concentration (0.5 per thousand) are increasingly oxidized by the microsomal ethanoloxidizing system (MEOS). Alcohol consumption induces several metabolic reactions as well as acute effects on the central nervous system. Chronic alcohol consumption to some extent irreparably damages nearly every organ with the liver being particularly concerned. There are three stages of alcohol-induced liver disease (fatty liver, alcohol hepatitis, liver cirrhosis) and the liver damages mainly result from reaction products of alcohol degradation (acetaldehyde, NADH and reactive oxygen species). An especially dreaded clinical complication of the alcohol-induced liver disease is the hepatic encephalopathy. Its pathogenesis is a multifactorial and self-perpetuating process with the swelling of astrocytes being a crucial point. Swollen astrocytes induce several reactions such as oxidative/nitrosative stress, impaired signal transduction, protein modifications and a modified gene expression profile. The swelling of astrocytes and the change in neuronal activity are attributed to several neurotoxins, especially ammonia and aromatic amino acids. In alcohol addicted subjects multiple micronutrient deficiencies are common. The status of folic acid, thiamine, pyridoxine and zinc is especially critical.

  3. Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall.

    Science.gov (United States)

    Ripperda, Christopher M; Maldonado, Pedro Antonio; Acevedo, Jesus F; Keller, Patrick W; Akgul, Yucel; Shelton, John M; Word, Ruth Ann

    2017-07-01

    Reconstructive surgery for pelvic organ prolapse is plagued with high failure rates possibly due to impaired healing or regeneration of the vaginal wall. Here, we tested the hypothesis that postoperative administration of local estrogen, direct injection of mesenchymal stem cells (MSCs), or both lead to improved wound healing of the injured vagina in a menopausal rat model. Ovariectomized rats underwent surgical injury to the posterior vaginal wall and were randomized to treatment with placebo (n = 41), estrogen cream (n = 47), direct injection of MSCs (n = 39), or both (n = 43). MSCs did not survive after injection and had no appreciable effects on healing of the vaginal wall. Acute postoperative administration of vaginal estrogen altered the response of the vaginal wall to injury with decreased stiffness, decreased collagen content, and decreased expression of transcripts for matrix components in the stromal compartment. Conversely, vaginal estrogen resulted in marked proliferation of the epithelial layer and increased expression of genes related to epithelial barrier function and protease inhibition. Transcripts for genes involved in chronic inflammation and adaptive immunity were also down-regulated in the estrogenized epithelium. Collectively, these data indicate that, in contrast to the reported positive effects of preoperative estrogen on the uninjured vagina, acute administration of postoperative vaginal estrogen has adverse effects on the early phase of healing of the stromal layer. In contrast, postoperative estrogen plays a positive role in healing of the vaginal epithelium after injury.

  4. Exclusive contracts in the hospital setting: a two-edged sword, part 1: legal issues.

    Science.gov (United States)

    Portman, Robert M

    2007-05-01

    Hospitals routinely enter into contracts with radiology groups for the right to be the exclusive provider of radiology services at the facility in exchange for the group agreeing to provide and manage all aspects of that service within the hospital. These "exclusive contracts" generally result in the radiology department and associated equipment being closed off to physicians who are not part of the contracting group. Exclusive contracts are generally considered to be good for physicians who have them and bad for those excluded by them. In fact, while exclusive contracts offer obvious benefits to the physicians who receive them and obvious disadvantages for those who are excluded, they also present pitfalls for physicians in the chosen group. Part I of this article discusses the legal issues raised by exclusive contracts. Although these agreements appear to be anti-competitive, most courts have rejected antitrust challenges to exclusive contracts. Excluded physicians have had much greater success in attacking exclusive contracting arrangements on breach of contract and procedural/due process grounds. Exclusive contracting arrangements can also raise concerns under the Medicare-Medicaid anti-kickback statute if the contracting physicians are required to pay consideration or accept less than fair market value compensation in exchange for exclusive contracts. These agreements can also raise issues under the Stark II physician self-referral law if the contracting physicians are in a position to refer Medicare or Medicaid patients to the hospital. Part II of this article will discuss the advantages and disadvantages of exclusive contracts for physicians covered and not covered by such contracts, as well as strategies for avoiding them or minimizing their potential adverse impact. It also will discuss specific provisions of exclusive contracts that should be included or avoided.

  5. My Patient, My Stalker Empathy as a Dual-Edged Sword: A Cautionary Tale.

    Science.gov (United States)

    Farber, Sharon K

    2015-01-01

    Success in psychotherapy is correlated with the "fit" between patient and therapist, a factor related to attachment. For psychotherapists of any orientation, empathy and building the bond of attachment is our stock-in-trade. When empathy builds the bond of attachment with someone starved for connection, a therapist may inadvertently set him- or herself up to become a victim of a stalker. Because individuals who stalk others suffer from severe attachment disorders, their hunger for attachment motivates them to shadow psychotherapists, which makes being stalked a very real occupational hazard for psychotherapists. This was a painful discovery for me. I was stalked for 11 months, leaving me with post-traumatic stress disorder. After recovering, I deconstructed the experience to understand how and why it happened, and discovered that it was my empathy and compassion that contributed to and maintained the stalking. What I learned from the forensic literature provided the knowledge and confidence needed to end the stalking. In this paper recommendations are made about how to prevent stalking and to halt it if it does happens.

  6. Arctigenin: A two-edged sword in ischemia/reperfusion induced acute kidney injury.

    Science.gov (United States)

    Han, Feng; Xia, Xin-Xin; Dou, Meng; Wang, Yu-Xiang; Xue, Wu-Jun; Ding, Xiao-Ming; Zheng, Jin; Ding, Chen-Guang; Tian, Pu-Xun

    2018-04-27

    Arctigenin (ATG) is one of the main active substances in fruit derived from Arctium lappa L. Previous studies have reported that ATG have antitumor, neuroprotective, antioxidant, antifibrosis and anti-inflammatory functions. However, the actions of ATG in kidney with acute injury following ischemia/ reperfusion (I/R) is still uncertain. In our study, mice were subjected to kidney I/R by having the kidney pedicles clamped and administered with vehicle or ATG (1, 3 or 9 mg/kg/d) via oral gavage for 7 consecutive days prior to I/R. Notably, ATG aggravated kidney I/R injury with the concentration increases. Multiple biochemical assays and histological examination showed ATG significantly alleviated the inflammatory response as reflected by a decreased expression of proinflammatory cytokine, TLR4/MyD88, and NF-κB, along with the infiltration of CD68 + macrophage and CD11b + Gr1 + neutrophil in the kidneys. Meanwhile, ATG alleviated I/R-induced oxidative stress proved by increasing kidney manganese superoxide dismutase and glutathione peroxidase activity but reducing levels of malonaldehyde and inducible nitric oxide synthase. On the contrary, apoptosis was significantly increased in kidneys of ATG-treated mice compared with vehicle-treated controls, especially in tubular cells. There were increased numbers of TUNEL positive cells and increased Bcl-2, Bax, cleaved-caspase-3, and cleaved-caspase-9 expression. The current study demonstrates that pretreatment of ATG aggravates I/R induced acute kidney injury by increasing apoptosis of tubular cells despite reducing infiltrating inflammatory cells and proinflammatory cytokine. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  7. Does pattern-welding make Anglo-Saxon swords stronger?

    DEFF Research Database (Denmark)

    Birch, Thomas

    2013-01-01

    to assess whether the technique affects mechanical properties, this experimental study compared pattern-welded and plain forged blanks in a series of material tests. Specimens were subject to tensile, Charpy and Vickers diamond hardness testing. This was to investigate the relative strength, ductility......The purpose of pattern-welding, used for the construction of some Anglo-Saxon swords, has yet to be fully resolved. One suggestion is that the technique enhanced the mechanical properties of a blade. Another explanation is that pattern-welding created a desired aesthetic appearance. In order...... and toughness of pattern-welding. The results were inconclusive, however the study revealed that the fracture performance of pattern-welding may relate to its use....

  8. Microstructural Features in Corroded Celtic Iron Age Sword Blades

    Science.gov (United States)

    Ghiara, G.; Piccardo, P.; Campodonico, S.; Carnasciali, M. M.

    2014-05-01

    Archaeological artefacts made from iron and steel are often of critical importance for archaeometallurgical studies, which aim to understand the process of manufacturing, as the nearly complete alloy mineralization does not allow for any type of metallographic interpretation. In this study, three Iron Age sword blades dated from the second century BC (LaTène B2/D1) found in the archaeological site of Tintignac (Commune de Naves, Corrèze, France), were investigated. A multianalytical approach was employed to acquire a complete range of data from the partially or totally corroded objects. Analyses were carried out with the use of light optical microscopy, micro Raman spectroscopy, and scanning electron microscopy equipped with energy-dispersive x-ray spectroscopy (EDXS). Remnants of metallographic features—ghost microstructure—in the corrosion layers of the blades were observed, allowing for a partial reconstruction of the manufacturing process.

  9. Carp’s-tongue swords - morphological, metallurgical and cultural aspects

    Directory of Open Access Journals (Sweden)

    Brandherm, Dirk

    2010-12-01

    Full Text Available This contribution discusses the results from a study of the spatial distribution of different morphological sub-groups of carp’s-tongue swords at a European scale, relating morphological types to the metallurgial make-up of the respective pieces. From this study some surprising conclusions concerning the chronological as well as the spatial dimension of the evolution of carp’s-tongue swords emerge. We also look at the degree of variability in the deposition of these artefacts and in the composition of the assemblages in question, with considerable repercussions for our understanding of the depositional contexts of metal objects in the Atlantic Bronze Age world in general.

    Se presentan los resultados de un análisis de la dispersión geográfica de los distintos subgrupos morfológicos de las espadas en lengua de carpa a nivel europeo, poniéndolas en relación con una marcada variabilidad en la composición metalúrgica de estas piezas, que lleva a conclusiones inesperadas sobre la dimensión temporal y espacial de su evolución. El análisis de la variabilidad en los ritos de deposición de estos artefactos y en la composición de los conjuntos en que se encuentran, tiene importantes repercusiones sobre nuestra imagen de los contextos deposicionales de los objetos metálicos en el mundo del Bronce Final atlántico en general.

  10. Edge Matters

    DEFF Research Database (Denmark)

    Earon, Ofri

    2013-01-01

    of this container is to separate inside from outside and to protect and provide privacy, psychological as well as physical (Venturi, 1966). But, if dwelling phenomenon takes place both inside and outside the private house – why is the urban house an enclosed box? What is the differentiation between inside...... and outside the contemporary urban house? And what is the interplay between them? The research argues for re-thinking the edge zone between inside and outside the urban house. Therefore, although, residential buildings in the city are the objects of study, the focal point here is the edge zone along...... the building. The research explores and develops the architectural characteristics of correlations between the resident, the singular unit, the building and the given location at the edge zone. It approaches the edge zone of the urban house as a platform for dynamic interactions between these behaviours...

  11. The metallographic examination of sword no. 438 as part of a systematic survey of swords from the early medieval stronghold of Mikulčice, Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Hošek, Jiří; Košta, J.; Bárta, P.

    2012-01-01

    Roč. 32, prosinec (2012), s. 87-102 ISSN 0436-029X R&D Projects: GA ČR GAP405/12/2289 Institutional support: RVO:67985912 Keywords : Mikulčice * Great Moravia * early medieval sword * archaeometallurgy Subject RIV: AC - Archeology, Anthropology, Ethnology

  12. If SWORD Is the Answer, What Is the Question?: Use of the Simple Web-Service Offering Repository Deposit Protocol

    Science.gov (United States)

    Lewis, Stuart; Hayes, Leonie; Newton-Wade, Vanessa; Corfield, Antony; Davis, Richard; Donohue, Tim; Wilson, Scott

    2009-01-01

    Purpose: The purpose of this paper is to describe the repository deposit protocol, Simple Web-service Offering Repository Deposit (SWORD), its development iteration, and some of its potential use cases. In addition, seven case studies of institutional use of SWORD are provided. Design/methodology/approach: The paper describes the recent…

  13. Victim’s posture and protective clothing changes the approach in an edged-weapon attack

    OpenAIRE

    Carr, D; Mahoney, P; Godhania, K; Cowper, E; Malbon, C

    2017-01-01

    Diverse groups of people use edged-weapons (i.e. knives, spears, swords) professionally. The training received affects how the edged-weapon is used and the area of the body targeted. There is a growing body of information available on the internet which is aimed at the training individuals in offensive knife attacks. This poster aims to raise awareness of this issue and highlight how a trained individual modifies an attack sequence depending on their victim’s posture and the protective clothi...

  14. Separation, Identification, and Bioactivities of the Main Gallotannins of Red Sword Bean (Canavalia gladiata) Coats

    Science.gov (United States)

    Gan, Ren-You; Kong, Kin-Weng; Li, Hua-Bin; Wu, Kao; Ge, Ying-Ying; Chan, Chak-Lun; Shi, Xian-Ming; Corke, Harold

    2018-02-01

    The red sword bean (Canavalia gladiata) is an underutilized edible bean cultivated in China. It was previously found to have the highest content of antioxidant polyphenols among 42 edible beans, mainly gallic acid and gallotannins in its red bean coat, an apparently unique characteristic among edible beans. In this study, the main phenolic compounds in red sword bean coats were further separated by Sephadex LH-20 column chromatography, and identified by LC-MS/MS. Furthermore, the FRAP and ABTS antioxidant activities and antibacterial activity (diameter of inhibition zone, DIZ) of main gallotannin-rich fractions were tested. Our results showed that gallotannins of red sword bean coats were mainly comprised of nonogalloyl to hexagalloyl hexosides. Interestingly, tetragalloyl, pentagalloyl, and hexagalloyl hexosides were identified as the main candidates responsible for the red color of the coats. On the other hand, gallotannin-rich fractions exhibited diverse antioxidant and antibacterial activities, and tetragalloyl hexoside overall had the highest free radical scavenging and antibacterial activities. The degree of galloylation did not completely explain the structure-function relationship of gallotannins isolated from red sword bean coats, as there should exist other factors affecting their bioactivities. In conclusion, red sword bean coats are excellent natural sources of gallotannins, and their gallotannin-rich extracts can be utilized as natural antioxidant and antibacterial agents with potential health benefits as well as application in food industry.

  15. Cutting edge: double-stranded DNA breaks in the IgV region gene were detected at lower frequency in affinity-maturation impeded GANP-/- mice.

    Science.gov (United States)

    Kawatani, Yousuke; Igarashi, Hideya; Matsui, Takeshi; Kuwahara, Kazuhiko; Fujimura, Satoru; Okamoto, Nobukazu; Takagi, Katsumasa; Sakaguchi, Nobuo

    2005-11-01

    Double-stranded DNA breaks (DSBs) at the IgV region (IgV) genes might be involved in somatic hypermutation and affinity-maturation of the B cell receptor in response to T cell-dependent Ag. By ligation-mediated PCR, we studied IgV DSBs that occurred in mature germinal center B cells in response to nitrophenyl-chicken gamma-globulin in a RAG1-independent, Ag-dependent, and IgV-selective manner. We quantified their levels in GANP-deficient B cells that have impaired generation of high-affinity Ab. GANP-/- B cells showed a decreased level of DSBs with blunt ends than control B cells and, on the contrary, the ganp gene transgenic (GANPTg) B cells showed an increased level. These results suggested that the level of IgV DSBs in germinal center B cells is associated with GANP expression, which is presumably required for B cell receptor affinity maturation.

  16. Sword of the early sarmatian period from the Ik-Zay interfluve

    Directory of Open Access Journals (Sweden)

    Izmaylov Iskander L

    2015-06-01

    Full Text Available A sword discovered in 2001 as a stray find in the area of Chaply village (Aznakayevsky District of the Tatarstan Republic is analyzed in the article. The sword is kept at Aznakayevsky Local History Museum. The shape of its guard and blade allowed the author to suggest its Sarmatian origin. Similar artifacts of Sarmatian culture suggest dating the sword by the late 4th - late 3rd cc. A.D., i.e. by the Prohorovo (Early Sarmatian period. This find is unique for the entire South-Eastern Tatarstan and was discovered far to the north of the main distribution area of the Sarmatian artifacts. It provides grounds for inclusion of this territory into the Prohorovo cultural area and should promote a more thorough study of artifacts at interfluves of minor rivers – the Kama tributaries – in order to identify and research barrows.

  17. From sword to chrysanthemum: Japan's culture of anti-miltarism

    International Nuclear Information System (INIS)

    Berger, T.U.

    1993-01-01

    The end of the Cold War and the phenomenal increase in Japan's economic and technological power put Japan today in the position to become, if it chooses, a military as well as economic superpower. The diminution of the Soviet threat and the increasing US preoccupation with domestic problems give Japan a latitude for independent action it has not had since the end of World War II. At the same time the US-Japanese security alliance, which has enabled Japan to adopt a minimalist approach to defense and national security, is being weakened by ideologically charged trade and other economic frictions and a growing American perception of Japan as a threat to its interests. Moreover, in the long run Japan faces the prospect of having to deal with other rising regional powers, most notably the People's Republic of China. This changing international security environment thus raises question whether Japan, having become an economic rival of the United States, may not in the future become a military competitor as well; whether, after having adopted a pacifist stance for half a century, Japan may choose to unsheathe its sword once again

  18. Analysis of Crystallographic Structure of a Japanese Sword by the Pulsed Neutron Transmission Method

    Science.gov (United States)

    Kino, K.; Ayukawa, N.; Kiyanagi, Y.; Uchida, T.; Uno, S.; Grazzi, F.; Scherillo, A.

    We measured two-dimensional transmission spectra of pulsed neutron beams for a Japanese sword sample. Atom density, crystalline size, and preferred orientation of crystals were obtained using the RITS code. The position dependence of the atomic density is consistent with the shape of the sample. The crystalline size is very small and shows position dependence, which is understood by the unique structure of Japanese swords. The preferred orientation has strong position dependence. Our study shows the usefulness of the pulsed neutron transmission method for cultural metal artifacts.

  19. « La psychologie est une arme à double tranchant » : Sigmund Freud et l’expertise judiciaire « Psychology is a Two-Edged Sword »: Freud and Court-Ordered Expertise

    Directory of Open Access Journals (Sweden)

    Brigitte Galtier

    2011-03-01

    Full Text Available Analyse de deux brefs textes critiques de Freud, écrits à la demande de juristes : « La psychanalyse et l’établissement des faits par voie diagnostique » (1906 et « L’expertise de la Faculté au procès Halsmann » (1931 nous instruisent d’une dérive de la Justice dans son recours à l’expertise psychiatrique (voire psychanalytique : le diagnostic ne sert plus à mesurer, une fois la culpabilité établie, le degré de responsabilité mais à étayer une accusation sans preuve.Analysis of two short texts by Freud, written at the request of a lawyer – “Psycho-Analysis and the Establishment of the Facts in Legal Proceedings” (1906 and “Faculty’s report in Halsmann’s trial” (1931 – is instructive with respect to the place of experts (psychiatrist or even psychoanalyst in relation to shifts in the concept of Justice: once culpability has been established, diagnosis is no longer used to assess the degree of responsibility, but to support a verdict of “not proven.”  

  20. The Orion Nebula: The Jewel in the Sword

    Science.gov (United States)

    2001-01-01

    Orion the Hunter is perhaps the best known constellation in the sky, well placed in the evening at this time of the year for observers in both the northern and southern hemispheres, and instantly recognisable. And for astronomers, Orion is surely one of the most important constellations, as it contains one of the nearest and most active stellar nurseries in the Milky Way, the galaxy in which we live. Here tens of thousands of new stars have formed within the past ten million years or so - a very short span of time in astronomical terms. For comparison: our own Sun is now 4,600 million years old and has not yet reached half-age. Reduced to a human time-scale, star formation in Orion would have been going on for just one month as compared to the Sun's 40 years. Just below Orion's belt, the hilt of his sword holds a great jewel in the sky, the beautiful Orion Nebula . Bright enough to be seen with the naked eye, a small telescope or even binoculars show the nebula to be a few tens of light-years' wide complex of gas and dust, illuminated by several massive and hot stars at its core, the famous Trapezium stars . However, the heart of this nebula also conceals a secret from the casual observer. There are in fact about one thousand very young stars about one million years old within the so-called Trapezium Cluster , crowded into a space less than the distance between the Sun and its nearest neighbour stars. The cluster is very hard to observe in visible light, but is clearly seen in the above spectacular image of this area ( ESO PR 03a/01 ), obtained in December 1999 by Mark McCaughrean (Astrophysical Institute Potsdam, Germany) and his collaborators [1] with the infrared multi-mode ISAAC instrument on the ESO Very Large Telescope (VLT) at Paranal (Chile). Many details are seen in the new ISAAC image ESO PR Photo 03b/01 ESO PR Photo 03b/01 [Preview - JPEG: 400 x 589 pix - 62k] [Normal - JPEG: 800 x 1178 pix - 648k] [Hires - JPEG: 1957 x 2881 pix - 2.7M] ESO PR Photo 03c

  1. The Research Interview as Discourses Crossing Swords: The Researcher and Apprentice on Crossing Roads

    Science.gov (United States)

    Tanggaard, Lene

    2007-01-01

    This article presents a conception of the qualitative research interview as discourses crossing swords. The article draws on examples showing how the researchers' view on learning is challenged by the interviewed apprentices. The apprentices do not assume learning in itself to be an important aspect of their lives. They consider the process of…

  2. Metallographic examination and reconstruction of the 6th century lombardic sword from Kyjov

    Czech Academy of Sciences Publication Activity Database

    Hošek, Jiří; Bárta, P.; Šmerda, J.

    2017-01-01

    Roč. 32, 7-8 (2017), s. 885-899 ISSN 1042-6914 R&D Projects: GA ČR GAP405/12/2289 Institutional support: RVO:67985912 Keywords : sword * Kyjov * metallography * Lombards Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology Impact factor: 2.274, year: 2016

  3. Edge Detection,

    Science.gov (United States)

    1985-09-01

    PROJECT. T ASK0 Artificial Inteligence Laboratory AREA It WORK UNIT NUMBERS V 545 Technology Square ( Cambridge, HA 02139 I I* CONTOOL1LIN@4OFFICE NAME...ARD-A1t62 62 EDGE DETECTION(U) NASSACNUSETTS INST OF TECH CAMBRIDGE 1/1 ARTIFICIAL INTELLIGENCE LAB E C HILDRETH SEP 85 AI-M-8 N99SI4-8S-C-6595...used to carry out this analysis. cce~iO a N) ’.~" D LI’BL. P p ------------ Sj. t i MASSACHUSETTS INSTITUTE OF TECHNOLOGY i ARTIFICIAL INTELLIGENCE

  4. Analysis of the dead layer of a detector of germanium with code ultrapure Monte Carlo SWORD-GEANT; Analisis del dead layer de un detector de germanio ultrapuro con el codigo de Monte Carlo SWORDS-GEANT

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo, S.; Querol, A.; Ortiz, J.; Rodenas, J.; Verdu, G.

    2014-07-01

    In this paper the use of Monte Carlo code SWORD-GEANT is proposed to simulate an ultra pure germanium detector High Purity Germanium detector (HPGe) detector ORTEC specifically GMX40P4, coaxial geometry. (Author)

  5. Living edge

    DEFF Research Database (Denmark)

    Earon, Ofri

    2014-01-01

    was originally introduced to enhance indoor qualities including light and view. Throughout the paper, it is argued that these ecological motives have grown to architectural and urban dimensions. The paper analyzes the characteristics and potentials of these dimensions and their interconnections. The paper...... on the ground level, but there is a lack of recognition in the significance of communicative characters as well at the higher part of the edge. The city’s planning approach is “Consider urban life before urban space. Consider urban space before buildings” This urban strategy neglects the possible architectural...... contribution to the street atmosphere and its effect on urban life. Bay balcony has been a common architectural element in Copenhagen’s residential buildings, since the end of the twenties. It is a domestic border with an architectural thickness combining window, door, windowsill and balcony. The bay balcony...

  6. Double peak spectra in spontaneous edge electroluminescence

    Czech Academy of Sciences Publication Activity Database

    Zavadil, Jiří; Žďánský, Karel

    1993-01-01

    Roč. 36, č. 11 (1993), s. 1623-1632 ISSN 0038-1101 R&D Projects: GA AV ČR IAA167108 Keywords : light emitting diodes * electroluminescence * optical waveguide theory Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.871, year: 1993

  7. Holy images on blades: unique swords from the State Hermitage Museum (preliminary publication

    Directory of Open Access Journals (Sweden)

    Vsevolod Obraztsov

    2013-12-01

    Full Text Available The focus of this article are interesting rarities from the collection of the State Hermitage Museum - swords of the 17th-18th centuries with inscriptions in Greek and Slavonic, with images of Christian saints inlaid in gold. The authors offer the general characteristics of 17 exemplars of this kind of arms which are divided into several groups according to the shape of the hilt. A brief overview of the relatively few publications on this subject includes articles by Vasilii Prokhorov (1877; data from the Index of the Medieval Department of the Imperial Hermitage published by Nikodim Kondakov (1891, a catalogue of Count Sergei Sheremetev's collection of arms compiled by Eduard Lenz (1895, and a monograph by E. Astvatsaturian on Turkish arms from the collection of the State Historical Museum (2002. The authors pay special attention to the description and analysis of two swords from the Hermit- age collection. One of them belonged to Count Michail Miloradovich, and was presented to him in 1807 from the city of Bucharest. The second sword came to the Hermitage after the Bolshevik Revolution from the Marble Palace, the residency of the Grand Dukes Konstantinovichi. Besides the traditional inscriptions and images of the Virgin with Child crowned by angels, the blade bears a unique image of Byzantine Emperor Nikephoros Phokas blessed by Jesus Christ with both hands. There are also two cartouches with quotations from Psalms in Greek. The extremely rich décor of this sword and the unique depiction of the Byzantine Emperor leave no doubt that they were made on a special order. The authors connect the sword to the Greek Project initiated by the Russian Empress Catherine the Great. The main idea of the project was a restoration of the Byzantine Empire with Constantinople-Istanbul as its capital, where Grand Duke Konstantin, Catherine the Great's grandchild, would be ascended to the throne. This article is a preliminary publication of a project in process

  8. Sulfur and iron accumulation in three marine-archaeological shipwrecks in the Baltic Sea: The Ghost, the Crown and the Sword

    Science.gov (United States)

    Fors, Yvonne; Grudd, Håkan; Rindby, Anders; Jalilehvand, Farideh; Sandström, Magnus; Cato, Ingemar; Bornmalm, Lennart

    2014-02-01

    Sulfur and iron concentrations in wood from three 17th century shipwrecks in the Baltic Sea, the Ghost wreck, the Crown and the Sword, were obtained by X-ray fluorescence (XRF) scanning. In near anaerobic environments symbiotic microorganisms degrade waterlogged wood, reduce sulfate and promote accumulation of low-valent sulfur compounds, as previously found for the famous wrecks of the Vasa and Mary Rose. Sulfur K-edge X-ray absorption near-edge structure (XANES) analyses of Ghost wreck wood show that organic thiols and disulfides dominate, together with elemental sulfur probably generated by sulfur-oxidizing Beggiatoa bacteria. Iron sulfides were not detected, consistent with the relatively low iron concentration in the wood. In a museum climate with high atmospheric humidity oxidation processes, especially of iron sulfides formed in the presence of corroding iron, may induce post-conservation wood degradation. Subject to more general confirmation by further analyses no severe conservation concerns are expected for the Ghost wreck wood.

  9. Methods of Manufacture of Swords in Medieval Europe: Illustrated by the Metallography of some Examples

    Directory of Open Access Journals (Sweden)

    Williams, Alan R.

    1977-12-01

    Full Text Available During the Dark Ages in Europe, the manufacture of the swords known as «pattern-welded», flourished. This type first appeared in the third century and disappeared by the tenth century A. D. Their characteristic appearance has drawn attention to them and numerous papers have been published describing their manufacture.

    No disponible. Consultar resumen en inglés.

  10. Non-destructive analysis of ancient bimetal swords from western Asia by γ-ray radiography and X-ray fluorescence

    Science.gov (United States)

    Shizuma, Kiyoshi; Kajimoto, Tsuyoshi; Endo, Satoru; Matsugi, Kazuhiro; Arimatsu, Yui; Nojima, Hisashi

    2017-09-01

    Eight ancient bimetal swords held by Hiroshima University, Japan were analyzed non-destructively through γ-ray radiography and X-ray fluorescence (XRF). 137Cs and 60Co γ-ray irradiation sources were used to obtain transmission images of swords. A scanning radiography method using a 60Co γ-ray source was developed. XRF was used for qualitative elemental analysis of the swords. The presence of iron cores in the hilts of some swords had been observed and it was assumed that the cores were a ritual symbol or had a functional purpose. However, our work reveals that these swords were originally bronze-hilted iron swords and that the rusty blades were replaced with bronze blades to maintain the swords' commercial value as an antique. Consequently, the rest of the iron blade was left in the hilt as an iron tang. The junction of the blade and the guard was soldered and painted to match the patina color. XRF analysis clearly showed that the elemental Sn/Cu ratios of the blades and the hilts were different. These findings are useful for clarifying the later modifications of the swords and are important for interpreting Bronze Age and Iron Age history correctly.

  11. Synthesis and characteristics of sword-like GaN nanorods clusters through ammoniating Ga2O3 thin films

    International Nuclear Information System (INIS)

    Xue Chengshane; Tian Deheng; Zhuang Huizhao; Zhang Xiaokai; Wu Yuxin; Liu Yi'an; He Jianting; Ai Yujie

    2006-01-01

    Sword-like GaN nanorods have been successfully synthesized by ammoniating Ga 2 O 3 thin films deposited on Si substrate by magnetron sputtering. The GaN nanorods have been characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED). SEM images show that sword-like GaN nanorods take on radial structure. The XRD and SAED analyses have identified that the nanorods are pure hexagonal GaN with single crystalline wurtzite structure. The HRTEM images indicate that the nanorods are well crystallized and nearly free from defects

  12. Is it ‘me’ or is it ‘mine’? The Mycenaean sword as a body-part.

    OpenAIRE

    Malafouris, Dr Lambros

    2008-01-01

    This paper argues that material culture has the ability to change and shape our bodies by transforming and extending the boundaries of our body schema. To explore this argument I concentrate on the relationship between the Mycenaean body and the Mycenaean sword. Focusing on the early Mycenaean period I propose that the centre of consciousness and bodily awareness for the Mycenaean person, and for the warrior in particular, is not some ‘internal’ Cartesian ‘I’, but the tip of the sword. Throug...

  13. Transcription and DNA Damage: Holding Hands or Crossing Swords?

    Science.gov (United States)

    D'Alessandro, Giuseppina; d'Adda di Fagagna, Fabrizio

    2017-10-27

    Transcription has classically been considered a potential threat to genome integrity. Collision between transcription and DNA replication machinery, and retention of DNA:RNA hybrids, may result in genome instability. On the other hand, it has been proposed that active genes repair faster and preferentially via homologous recombination. Moreover, while canonical transcription is inhibited in the proximity of DNA double-strand breaks, a growing body of evidence supports active non-canonical transcription at DNA damage sites. Small non-coding RNAs accumulate at DNA double-strand break sites in mammals and other organisms, and are involved in DNA damage signaling and repair. Furthermore, RNA binding proteins are recruited to DNA damage sites and participate in the DNA damage response. Here, we discuss the impact of transcription on genome stability, the role of RNA binding proteins at DNA damage sites, and the function of small non-coding RNAs generated upon damage in the signaling and repair of DNA lesions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. The Pill Really Can Be Mightier Than the Sword: A Response to Recent Commentaries

    Directory of Open Access Journals (Sweden)

    Malcolm Potts

    2016-03-01

    Full Text Available We appreciate the four commentaries that add new material and fresh perspectives to our article “The pill is mightier than the sword.” In emphasizing the role of voluntary family planning and girls’ education as achievable strategies with a potential to make the world a more peaceable place, we did not mean to oversimplify or disregard the intrinsic complexity of human conflict. On the whole, the commentators support and add to our thesis, although we question Pillai and Ya-Chien Wang’s suggestion that we may have overstated the unique human predisposition to kill our own species. We present additional data on male team aggression.

  15. New elements for the definition of swords "Thapsos type" from Bronze Age contexts in Sicily

    Directory of Open Access Journals (Sweden)

    Carlo Veca

    2016-12-01

    Full Text Available The paper deals with the problem of metal weapons from contexts of southern Italy and Sicily between the half of 15th and the half of 13th century BC. Weapons and related military schemes seem to develop gradually through the definition of standards of technology and function, traditionally associated to the swords of Pertosa Type. The accurate analysis of many specimens from Sicily allowed to make clear the level of relations/differences in the weapons of treated contexts, in order to define the "Thapsos Type", distinct and independent from Pertosa Group

  16. Stability of edge states and edge magnetism in graphene nanoribbons

    OpenAIRE

    Kunstmann, Jens; Özdoğan, Cem; Quandt, Alexander; Fehske, Holger

    2010-01-01

    We critically discuss the stability of edge states and edge magnetism in zigzag edge graphene nanoribbons (ZGNRs). We point out that magnetic edge states might not exist in real systems, and show that there are at least three very natural mechanisms - edge reconstruction, edge passivation, and edge closure - which dramatically reduce the effect of edge states in ZGNRs or even totally eliminate them. Even if systems with magnetic edge states could be made, the intrinsic magnetism would not be ...

  17. Nanoindentation near the edge

    Science.gov (United States)

    J.E. Jakes; C.R. Frihart; J.F. Beecher; R.J. Moon; P.J. Resto; Z.H. Melgarejo; O.M. Saurez; H. Baumgart; A.A. Elmustafa; D.S. Stone

    2009-01-01

    Whenever a nanoindent is placed near an edge, such as the free edge of the specimen or heterophase interface intersecting the surface, the elastic discontinuity associated with the edge produces artifacts in the load-depth data. Unless properly handled in the data analysis, the artifacts can produce spurious results that obscure any real trends in properties as...

  18. HCI Design Patterns for C2: A Vision for a DoD Design Reference Library

    National Research Council Canada - National Science Library

    Stanard, Terry; Wampler, Jeffrey L; Conrad, Kendall; Osga, Glenn

    2006-01-01

    .... However, NCO is a double edged sword for C2 centers. While it offers information sharing like never before, it creates new task demands of info management with the potential for warfighters to get lost in the sea of data...

  19. Critical Evaluation on Games as a Classroom Activity in EFL Learning Context

    Institute of Scientific and Technical Information of China (English)

    ZHOU; Xin

    2014-01-01

    Game is a double-edged sword.Though games can definitely arouse students’ interests of learning and make students active and enthusiastic in EFL classroom, it is challenging for teachers to manage the games and achieve expected teaching objectives.

  20. Planning ahead for livable communities along the Powell–Division Bus Rapid Transit : neighborhood conditions and change.

    Science.gov (United States)

    2017-07-04

    New transit investments can be a double-edged sword for disadvantaged communities (e.g., those included in environmental justice and Title VI protected classes). Transit investments improve communities mobility and access, and may improve health w...

  1. Qualitative study about the ways teachers react to feedback from resident evaluations

    NARCIS (Netherlands)

    Roermund, T. van; Schreurs, M.L.; Mokkink, H.; Bottema, B.; Scherpbier, A.; Weel, C. van

    2013-01-01

    BACKGROUND: Currently, one of the main interventions that are widely expected to contribute to teachers' professional development is confronting teachers with feedback from resident evaluations of their teaching performance. Receiving feedback, however, is a double edged sword. Teachers see

  2. Differential regulation of msx genes in the development of the gonopodium, an intromittent organ, and of the "sword," a sexually selected trait of swordtail fishes (Xiphophorus).

    Science.gov (United States)

    Zauner, Hans; Begemann, Gerrit; Marí-Beffa, Manuel; Meyer, Axel

    2003-01-01

    The possession of a conspicuous extension of colored ventral rays of the caudal fin in male fish of swordtails (genus Xiphophorus) is a prominent example for a trait that evolved by sexual selection. To understand the evolutionary history of this so-called sword molecularly, it is of interest to unravel the developmental pathways responsible for extended growth of sword rays during development of swordtail males. We isolated two msx genes and showed that they are differentially regulated during sword outgrowth. During sword growth in juvenile males, as well as during testosterone-induced sword development and fin ray regeneration in the sword after amputation, expression of msxC is markedly up-regulated in the sword forming fin rays. In contrast, msxE/1 is not differentially expressed in ventral and dorsal male fin rays, suggesting a link between the development of male secondary sexual characters in fins and up-regulation of msxC expression. In addition, we showed that msx gene expression patterns differ significantly between Xiphophorus and zebrafish. We also included in our study the gonopodium, a testosterone-dependent anal fin modification that serves as a fertilization organ in males of live-bearing fishes. Our finding that increased levels of msxC expression are associated with the testosterone-induced outgrowth of the gonopodium might suggest either that at least parts of the signaling pathways that pattern the evolutionary older gonopodium have been coopted to evolve a sexually selected innovation such as the sword or that increased msxC expression may be inherent to the growth process of long fin rays in general.

  3. An edge pedestal model

    International Nuclear Information System (INIS)

    Stacev, W.M.

    2001-01-01

    A new model for calculation of the gradient scale lengths in the edge pedestal region and of the edge transport barrier width in H-mode tokamak plasmas will be described. Model problem calculations which demonstrate the promise of this model for predicting experimental pedestal properties will be discussed. The density and Prague gradient scale lengths (L) in the edge are calculated from the particle and ion and electron energy radial transport equations, making use of (presumed) known particle and energy fluxes flowing across the edge transport barrier from the core into the SOL and of edge transport coefficients. The average values of the particle and heat fluxes in the edge transport barrier are calculated in terms of the fluxes crossing into the SOL and the atomic physics reaction rates (ionisation, charge-exchange, elastic scattering, impurity radiation) in the edge by integrating the respective transport equations from the pedestal to the separatrix. An important implication of this model is that the pedestal gradient scale lengths depend not just on local pedestal platers properties but also on particle and energy fluxes from the core plasma and on recycling neutral fluxes that penetrate into the plasma edge, both of which in turn depend on the pedestal properties. The MHD edge pressure gradient constraint α≤ α C is used to determine the pressure width of the edge transport barrier, Δ TB = Δ TB (α c ). Three different models for the MHD edge pressure gradient constraint have been investigated: (1) nominal ideal ballooning mode theory, (2) ballooning mode theory taking into account the edge geometry and shear to access He second stability region; and pedestal β-limit theory when the ballooning modes are stabilised by diamagnetic effects. A series of calculations have been made for a DIII-D model problem. The calculated gradient scale lengths and edge transport barrier widths are of the magnitude of values observed experimentally, and certain trends

  4. Gait alterations can reduce the risk of edge loading.

    Science.gov (United States)

    Wesseling, Mariska; Meyer, Christophe; De Groote, Friedl; Corten, Kristoff; Simon, Jean-Pierre; Desloovere, Kaat; Jonkers, Ilse

    2016-06-01

    Following metal-on-metal hip arthroplasty, edge loading (i.e., loading near the edge of a prosthesis cup) can increase wear and lead to early revision. The position and coverage angle of the prosthesis cup influence the risk of edge loading. This study investigates the effect of altered gait patterns, more specific hip, and pelvis kinematics, on the orientation of hip contact force and the consequent risk of antero-superior edge loading using muscle driven simulations of gait. With a cup orientation of 25° anteversion and 50° inclination and a coverage angle of 168°, many gait patterns presented risk of edge loading. Specifically at terminal double support, 189 out of 405 gait patterns indicated a risk of edge loading. At this time instant, the high hip contact forces and the proximity of the hip contact force to the edge of the cup indicated the likelihood of the occurrence of edge loading. Although the cup position contributed most to edge loading, altering kinematics considerably influenced the risk of edge loading. Increased hip abduction, resulting in decreasing hip contact force magnitude, and decreased hip extension, resulting in decreased risk on edge loading, are gait strategies that could prevent edge loading. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1069-1076, 2016. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  5. On dynamical evolution of the bright star subsystem in the Orion Sword cluster

    International Nuclear Information System (INIS)

    Dolgachev, V.P.; Kalinina, E.P.; Kholopov, P.N.

    1989-01-01

    With the help of numerical integration of the system of ordinary differential equations of the 102nd order, a possible dynamical evolution of the subsystem of 17 brightest stars in the Orion Sword open cluster has been examined in the interval of 20,1x10 6 years. In the process of transition through the region occupied by the cluster core taking place with a ''cycle'' of about 7 million years, the brightest stars of the cluster begin to concentrate mostly in the core region. Some of them acquire motions along elongated orbits, remaining during a long time in the limits of the cluster's corona, while one of stars is thrown away from the cluster with the hyperbolic velocity. Moreover, two wide pairs of stars are originating, which are analogous to those observed in the galactic field

  6. Energetic ion excited long-lasting ``sword'' modes in tokamak plasmas with low magnetic shear

    Science.gov (United States)

    Wang, Xiaogang; Zhang, Ruibin; Deng, Wei; Liu, Yi

    2013-10-01

    An m/ n = 1 mode driven by trapped fast ions with a sword-shape envelope of long-lasting (for hundreds of milliseconds) magnetic perturbation signals, other than conventional fishbones, is studied in this paper. The mode is usually observed in low shear plasmas. Frequency and growth rate of the mode and its harmonics are calculated and in good agreements with observations. The radial mode structure is also obtained and compared with that of fishbones. It is found that due to fast ion driven the mode differs from magnetohydrodynamic long lived modes (LLMs) observed in MAST and NSTX. On the other hand, due to the feature of weak magnetic shear, the mode is also significantly different from fishbones. The nonlinear evolution of the mode and its comparison with fishbones are further investigated to analyze the effect of the mode on energetic particle transport and confinement.

  7. A Taxonomic Review of the Sword-tailed Cricket Subfamily Trigonidiinae (Orthoptera: Ensifera: Gryllidae from Korea

    Directory of Open Access Journals (Sweden)

    Tae-Woo Kim

    2013-01-01

    Full Text Available The Korean population of the sword-tailed cricket subfamily Trigonidiinae is reviewed for the first time. Four members of the crickets are confirmed based on the examined material, those are Metioche japonica (Ichikawa, 2001, Svistella bifasciata (Shiraki, 1911, Homoeoxipha obliterata (Caudell, 1927 and Natula matsuurai Sugimoto, 2001, each of them belonging to a different genera. Among them, the former two are reconfirmed since earlier records, and latter two are newly recognized genera and species from the far southern provinces Jeollanam-do and Jeju-do Island in Korea. The type locality of both crickets is Japan, and are also only previously referred to in Japan, but their distributional ranges include neighboring South Korea. A key to the species, descriptions, photographs, figures, and oscillograms of male’s calling sounds are provided to aid their identification.

  8. Nanostructure sword-like ZnO wires: Rapid synthesis and characterization through a microwave-assisted route

    International Nuclear Information System (INIS)

    Kajbafvala, Amir; Shayegh, Mohammad Reza; Mazloumi, Mahyar; Zanganeh, Saeid; Lak, Aidin; Mohajerani, Matin Sadat; Sadrnezhaad, S.K.

    2009-01-01

    Nanostructure sword-like ZnO wires with diameters of about 80-250 nm and the length of ∼1-4 μm have been synthesized by a fast, simple and template-free microwave-assisted method. X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy and room temperature photoluminescence (PL) measurements was used for characterization of the as-prepared products. The nanostructure sword-like ZnO wires have high crystallinity with the average crystallite size of about 53 nm and show a UV emission and a visible green band in their PL spectrum. The possible growth mechanism of the nanostructures along the crystallographic direction and subsequent formation of wires were also investigated

  9. Determination of trace elements in Katana (Japanese sword) by neutron activation analysis with multidimensional γ-ray spectrometry

    International Nuclear Information System (INIS)

    Okada, Y.; Hirai, S.; Ohya, S.; Kimura, Atsushi; Hatsukawa, Yuichi; Toh, Yosuke; Koizumi, Mitsuo; Oshima, Masumi

    2006-01-01

    In this study, we tried to measure trace elements (As and Sb) in Katana (Japanese swords) by multidimensional γ-ray spectrometry method (GEMINI-II) and conventional counting method for neutron activation analysis (NAA). The determined values by GEMINI-II and conventional counting were in good agreement with. Using the multidimensional γ-ray spectrometry (GEMINI-II) to determine As and Sb was improved by 7 times and 10 times compared with the conventional counting method. (author)

  10. The Pill vs. the Sword: Additional Considerations; Comment on “The Pill Is Mightier Than the Sword”

    Directory of Open Access Journals (Sweden)

    Ilsa L. Lottes

    2015-12-01

    Full Text Available In this paper, I present additional information for policy-makers and researchers to consider in response to the view proposed by Potts et al that “the pill is mightier than the sword.” I identify states with both high rates of terrorism and a youth bulge and discuss correlates of both these societal characteristics. The research examined supports the view that factors other than access to family planning are more important in facilitating terrorism.

  11. Epidemiology of occupational hypersensitivity pneumonitis; reports from the SWORD scheme in the UK from 1996 to 2015

    Science.gov (United States)

    Barber, C M; Wiggans, R E; Carder, M; Agius, R

    2017-01-01

    Objective To estimate the reported incidence of occupational hypersensitivity pneumonitis (OHP) in the UK and to consider whether the pattern of attributed causation has changed over time. Methods All cases of OHP reported to the SWORD scheme between January 1996 and December 2015 were classified into 1 of 10 categories of the suspected agent. Cases were grouped into four 5-year time periods to examine any changing pattern in incidence or suspected causation. For each time period, the annual incidence was calculated using the estimated number of reported cases and the working population of the UK. Results Between 1996 and 2015, there were 202 actual cases of OHP reported to SWORD, equating to an estimated 818 cases, when adjusting for the sampling ratio. Over this period, the annual UK incidence was 1.4 per million workers. The mean (SD) age of reported cases was 52 (13) years, and cases were four-times more likely to be men than women. Over the study period, there was a fall in the proportion of cases reported to be due to agricultural exposures (44–12%), and an increase in cases due to metalworking fluids (MWFs, 2–45%). Conclusions Over the last 20 years, the incidence of OHP in the UK has been ∼1–2 cases per million workers per year. Working with water-based MWFs is now the most commonly suspected causative exposure for OHP cases reported to the SWORD scheme in the UK. PMID:27919062

  12. Rainbow Sword

    DEFF Research Database (Denmark)

    Elias, Camelia

    2012-01-01

    In this essay I look at Tarot as a cultural text. What does this mean? This means that I look at how the visual language of Tarot intersects with cultural precepts about a given phenomenon, a type, an archetype, a relation (of class, gender, race, sex), reality, magic, and the physical...... and metaphysical world. This is already more than what most people associate with Tarot: a fortunetelling device that the gypsies, neo-pagan witches, and other such devils employ in their charlatan endeavor to cheat venerable people out of their money. By taking point of departure in tarot history, I look here...

  13. Edge effects in composites

    International Nuclear Information System (INIS)

    Guz, A.N.; Kokhanenko, Yu.V.

    1995-01-01

    In the present article we survey papers on edge effects investigated by the rigorous approach. We interpret edge effects as stressed states created in a composite as a result of zones in which the stresses exhibit a rapidly changing behavior in comparison with the slow variation of the stresses outside such zones. Here the range of the edge effect is defined as the distance from the point of its inception to the boundary of the edge zone in a given direction. The transition of the stresses to the slowly varying state is determined within prescribed error limits. The size and configuration of the edge zone depends on the tolerated error. Clearly, the main difficulty associated with the rigorous approach is finding solutions of the elasticity problems. The finite-difference approach is suggested for the approximate solution of these problems. In light of the comparative time consumption of the finite-difference approach, it is best directed at certain classes of problems rather than at particular individual problems. Not too many papers on the investigation of edge effects by the rigorous approach have been published to date. Below, following in their footsteps, we formulate edge effect problems in composites, determine classes of problems, and investigate edge effects in composite materials and structural elements using them in Cartesian (planar and three-dimensional problems) and cylindrical (axisymmetric problems) coordinate frames. We note that the division of approaches to the study of edge effects into qualitative (nonrigorous) and quantitative (rigorous) reflects the authors own point of view. Of course, other schemes of classification of the approaches to the investigation of the regions of rapidly varying states in composites are possible

  14. Edge colouring by total labellings

    DEFF Research Database (Denmark)

    Brandt, Stephan; Rautenbach, D.; Stiebitz, M.

    2010-01-01

    We introduce the concept of an edge-colouring total k-labelling. This is a labelling of the vertices and the edges of a graph G with labels 1, 2, ..., k such that the weights of the edges define a proper edge colouring of G. Here the weight of an edge is the sum of its label and the labels of its...

  15. Adobe Edge Quickstart Guide

    CERN Document Server

    Labrecque, Joseph

    2012-01-01

    Adobe Edge Quickstart Guide is a practical guide on creating engaging content for the Web with Adobe's newest HTML5 tool. By taking a chapter-by-chapter look at each major aspect of Adobe Edge, the book lets you digest the available features in small, easily understandable chunks, allowing you to start using Adobe Edge for your web design needs immediately. If you are interested in creating engaging motion and interactive compositions using web standards with professional tooling, then this book is for you. Those with a background in Flash Professional wanting to get started quickly with Adobe

  16. Adobe Edge Preview 3

    CERN Document Server

    Grover, Chris

    2011-01-01

    Want to use an Adobe tool to design animated web graphics that work on iPhone and iPad? You've come to the right book. Adobe Edge Preview 3: The Missing Manual shows you how to build HTML5 graphics using simple visual tools. No programming experience? No problem. Adobe Edge writes the underlying code for you. With this eBook, you'll be designing great-looking web elements in no time. Get to know the workspace. Learn how Adobe Edge Preview 3 performs its magic.Create and import graphics. Make drawings with Edge's tools, or use art you designed in other programs.Work with text. Build menus, lab

  17. Pavement edge treatment.

    Science.gov (United States)

    2013-01-01

    Four projects were built over two construction seasons using special devices attached to the paving machine that produces a 30 slope on the outside pavement edge instead of the near vertical drop-off common with conventional paving equipment. This ...

  18. Edge and core dynamics in harness

    International Nuclear Information System (INIS)

    Ball, R.

    2007-01-01

    Resistive kink oscillations in tokamak plasmas are usually treated as core localized events, yet there there are several mechanisms by which they may interact with the edge dynamics. This suggests that we may regulate edge oscillatory behaviour, or ELMs, by harnessing the natural or contrived sawtooth period and amplitude. In this work I investigate core-edge oscillatory entrainment through direct propagation of heat pulses, inductive coupling, and global higher order resonance effects. In the core of auxiliary heated tokamak plasmas the ineluctable rhythm of slow buildup and rapid conversion of potential energy governs electron and heat radial transport. The growth phase of the sawtooth is accompanied by significant reconnection, then during the collapse the temperature and density in the core fall dramatically. There is evidence from experiments in reversed field pinch devices that ensuing energy fluxes can affect flow shear and confinement at the edge. The basis for this study is the dynamical (BDS) model for edge plasma behavior that was derived from electrostatic resistive MHD equations. The BDS model reflects the major qualitative features of edge dynamics that have been observed, such as L-H transitions and associated ELMs, hysteresis, and spontaneous reversal of poloidal shear flow. Under poorly dissipative conditions the transient behavior of the model can exhibit period-doubling, blue-sky, homoclinic, and other exotic bifurcations. Thus we might ask questions such as: Is it possible to mode-lock the edge dynamics to the core sawteeth? Can we induce, or prevent, a change in direction of shear flow? What about MHD effects? Is core-edge communication one way or is there some feedback? In the simplest prototype for coupled core-edge dynamics I model the sawtooth crash as a periodic power input to the edge potential energy reservoir. This is effected by coupling the BDS model to the dynamical system u = u(1 - u 2 - x 2 ) - ω s x, x = x(1-u 2 -x 2 ) + ω s u

  19. Analyzing Double Image Illusion through Double Indiscernibility and Lattice Theory

    Directory of Open Access Journals (Sweden)

    Kohei Sonoda

    2011-10-01

    Full Text Available The figure-ground division plays a fundamental role in all image perceptions. Although there are a lot of studies about extraction of a figure such as detection of edges or grouping of texture, there are few discussions about a relationship between obtained figure and ground. We focused on double image illusions having two complementary relationships be- tween figure and ground and analyzed them. We divided the double image illusions according to two different interpretations and using these divisions we extracted and analyzed their logical structures by lattices derived from rough sets that we had developed. As a result we discovered unusual logical structures in double image illusions.

  20. Edge Simulation Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Krasheninnikov, Sergei I. [Univ. of California, San Diego, CA (United States); Angus, Justin [Univ. of California, San Diego, CA (United States); Lee, Wonjae [Univ. of California, San Diego, CA (United States)

    2018-01-05

    The goal of the Edge Simulation Laboratory (ESL) multi-institutional project is to advance scientific understanding of the edge plasma region of magnetic fusion devices via a coordinated effort utilizing modern computing resources, advanced algorithms, and ongoing theoretical development. The UCSD team was involved in the development of the COGENT code for kinetic studies across a magnetic separatrix. This work included a kinetic treatment of electrons and multiple ion species (impurities) and accurate collision operators.

  1. Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy?

    Science.gov (United States)

    Rayan, Mona; Tawfik, Mazen; Alabd, Ali; Gamal, Amr

    2011-08-01

    To prospectively assess the safety and efficacy of ivabradine in patients with idiopathic dilated cardiomyopathy. We included 35 patients with idiopathic dilated cardiomyopathy with an ejection fraction (EF) 70 beats/min despite optimal medical therapy, according to the international guidelines in this prospective, non-randomized, single-arm, open-label safety study. Ivabradine was used as an add-on therapy to the maximally tolerated b-blocker in an increasing titrated dose till a target dose of 15 mg/day or resting heart rate of 60 beats/min for 3 months. During follow-up period the safety, patient tolerance and efficacy of this drug were assessed. All patients underwent 12-lead resting electrocardiography and Holter monitoring at inclusion and after 3 months. Statistical analysis was accomplished using paired t-test and Pearson correlation analysis. We found a significant reduction in the resting heart rate by a mean of 25.9 ± 9.4%, without a significant change of blood pressure. There was no prolongation of PR, QTc or QRS durations. Ventricular ectopic activity showed significant reduction (p<0.001). There was a significant correlation between the resting heart rate, NYHA and left ventricular ejection fraction (p<0.001 for both). One patient developed photopsia and decompensation was observed in another patient. Ivabradine is a safe and effective drug in reducing resting heart rate, improving NYHA functional class without undesirable effects on conduction parameters or ectopic activity.

  2. The Edge supersonic transport

    Science.gov (United States)

    Agosta, Roxana; Bilbija, Dushan; Deutsch, Marc; Gallant, David; Rose, Don; Shreve, Gene; Smario, David; Suffredini, Brian

    1992-01-01

    As intercontinental business and tourism volumes continue their rapid expansion, the need to reduce travel times becomes increasingly acute. The Edge Supersonic Transport Aircraft is designed to meet this demand by the year 2015. With a maximum range of 5750 nm, a payload of 294 passengers and a cruising speed of M = 2.4, The Edge will cut current international flight durations in half, while maintaining competitive first class, business class, and economy class comfort levels. Moreover, this transport will render a minimal impact upon the environment, and will meet all Federal Aviation Administration Part 36, Stage III noise requirements. The cornerstone of The Edge's superior flight performance is its aerodynamically efficient, dual-configuration design incorporating variable-geometry wingtips. This arrangement combines the benefits of a high aspect ratio wing at takeoff and low cruising speeds with the high performance of an arrow-wing in supersonic cruise. And while the structural weight concerns relating to swinging wingtips are substantial, The Edge looks to ever-advancing material technologies to further increase its viability. Heeding well the lessons of the past, The Edge design holds economic feasibility as its primary focus. Therefore, in addition to its inherently superior aerodynamic performance, The Edge uses a lightweight, largely windowless configuration, relying on a synthetic vision system for outside viewing by both pilot and passengers. Additionally, a fly-by-light flight control system is incorporated to address aircraft supersonic cruise instability. The Edge will be produced at an estimated volume of 400 aircraft and will be offered to airlines in 2015 at $167 million per transport (1992 dollars).

  3. Properties on the edge: graphene edge energies, edge stresses, edge warping, and the Wulff shape of graphene flakes

    International Nuclear Information System (INIS)

    Branicio, Paulo S; Jhon, Mark H; Gan, Chee Kwan; Srolovitz, David J

    2011-01-01

    It has been shown that the broken bonds of an unreconstructed graphene edge generate compressive edge stresses leading to edge warping. Here, we investigate edge energies and edge stresses of graphene nanoribbons with arbitrary orientations from armchair to zigzag, considering both flat and warped edge shapes in the presence and absence of hydrogen. We use the second generation reactive empirical bond order potential to calculate the edge energies and stresses for clean and hydrogenated edges. Using these energies, we perform a Wulff construction to determine the equilibrium shapes of flat graphene flakes as a function of hydrogen chemical potential. While edge stresses for clean, flat edges are compressive, they become tensile if allowed to warp. Conversely, we find that edge energies change little (∼1%) with edge warping. Hydrogenation of the edges virtually eliminates both the edge energy and edge stresses. For warped edges an approximately linear relationship is found between amplitudes and wavelengths. The equilibrium shape of a graphene flake is determined by the value of the hydrogen chemical potential. For very small (and large) values of it the flakes have a nearly hexagonal (dodecagon) shape with zigzag oriented edges, while for intermediate values graphene flakes are found with complex shapes

  4. Theory of edge radiation

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, G.; Kocharyan, V.; Saldin, E.; Schneidmiller, E.; Yurkov, M.

    2008-08-15

    We formulate a complete theory of Edge Radiation based on a novel method relying on Fourier Optics techniques. Similar types of radiation like Transition UndulatorRadiation are addressed in the framework of the same formalism. Special attention is payed in discussing the validity of approximations upon which the theory is built. Our study makes consistent use of both similarity techniques and comparisons with numerical results from simulation. We discuss both near and far zone. Physical understanding of many asymptotes is discussed. Based on the solution of the field equation with a tensor Green's function technique, we also discuss an analytical model to describe the presence of a vacuum chamber. In particular, explicit calculations for a circular vacuum chamber are reported. Finally, we consider the use of Edge Radiation as a tool for electron beam diagnostics. We discuss Coherent Edge Radiation, Extraction of Edge Radiation by a mirror, and other issues becoming important at high electron energy and long radiation wavelength. Based on this work we also study the impact of Edge Radiation on XFEL setups and we discuss recent results. (orig.)

  5. More a plowshare than a sword: the legacy of US Cold War agricultural diplomacy.

    Science.gov (United States)

    McGlade, Jacqueline

    2009-01-01

    Recently, agriculture has assumed an elevated role in world diplomacy due to pressing issues like international poverty relief, changing environmental conditions, farm trade imbalances, rising food prices, and the diversion of crops into bio-fuel production. Consequently, agricultural interests and production have become increasingly entwined with the politics of national protectionism and identity, domestic security, and the preservation of trading advantage in developed and developing countries alike. This study examines the current impasse in world agricultural negotiations as an outgrowth of US foreign aid and trade policymaking as it evolved during the Cold War. In particular, it chronicles the historic shift in US foreign policy away from "give-away" food aid and surplus sales and toward the championing of global agricultural redevelopment under such programs as the Marshall Plan and PL 480, the Food for Peace program. As more a plowshare than a sword, the American Cold War push for worldwide agricultural modernization led many countries to experience new levels of food self-efficiency and export capabilities. Along with production parity, however, has come escalating levels of trade competition and national protectionism, which challenges again the achievement of world agricultural stability and prosperity.

  6. Effects of Hull Scratching, Soaking, and Boiling on Antinutrients in Japanese Red Sword Bean (Canavalia gladiata).

    Science.gov (United States)

    Une, Satsuki; Nonaka, Koji; Akiyama, Junich

    2016-10-01

    The effects of hull processing, soaking, and boiling on the content or activity of antinutrients in the red sword bean (RSB; Canavalia gladiata) were investigated. RSB seeds were compared with kidney bean (KB; Phaseolus vulgaris) seeds that are starch based and often used as processed products in Japan. RSB seeds had higher weight, thicker hull, and higher protein content, but lower moisture content compared with KB seeds. Because of the strong and thick hull, the relative water absorption of untreated RSB seeds was very low after soaking. Seeds were soaked after dehulling, scratching, and roasting. The results showed that hull scratching was the optimal method for increasing water absorption during soaking compared with dehulling and roasting. After soaking, the water used for soaking was discarded, since it had a high content of polyphenols and bitter taste, and RSB seeds were boiled in fresh water for 20, 40, and 60 min. The results showed that polyphenol and tannin contents, antioxidant activity, and hemagglutinating activity, as well as maltase, sucrase, and trypsin inhibitor activities in scratched RSB seeds decreased significantly after boiling compared with those in raw seeds, whereas amylase inhibitor activity showed no significant change. Overall, it was concluded that the combination of hull scratching, soaking, and boiling in fresh water can reduce thermal-stable or sensitive antinutrients in RSB and thus, significantly improve its nutritional value. © 2016 Institute of Food Technologists®.

  7. Leather material found on a 6th B.C. Chinese bronze sword: A technical study

    Science.gov (United States)

    Luo, Wugan; Si, Yi; Wang, Hongmin; Qin, Ying; Huang, Fengchun; Wang, Changsui

    2011-09-01

    During July to November, 2006, an important archaeological excavation was conducted in Yun country, Hubei province, southern China. Chinese archaeologists found some remnant of leather materials, covered with red pigments, on a 6th century B.C. Chinese bronze sword. To understand the technology/ies that may have been utilized for manufacturing the leathers, a combined of Raman spectroscopy, FT-IR and XRF was thus applied to the remnant of leather materials. Raman analyses showed that red pigment on the leather was cinnabar (HgS). FT-IR and XRF analyses indicated that the content of some elements, such as Ca (existing as CaCO 3) and Fe (existing as Fe 2O 3), were much higher than those in the surrounding grave soil. The results inferred an application of lime depilation and retting, and the Fe-Al compound salt as tanning agent. And it was furthermore implicated that the Fe-Al salt tanning technique had been developed in the middle and late Spring and Autumn Period of China.

  8. High Speed Edge Detection

    Science.gov (United States)

    Prokop, Norman F (Inventor)

    2016-01-01

    Analog circuits for detecting edges in pixel arrays are disclosed. A comparator may be configured to receive an all pass signal and a low pass signal for a pixel intensity in an array of pixels. A latch may be configured to receive a counter signal and a latching signal from the comparator. The comparator may be configured to send the latching signal to the latch when the all pass signal is below the low pass signal minus an offset. The latch may be configured to hold a last negative edge location when the latching signal is received from the comparator.

  9. Edge detection in landing budgerigars (Melopsittacus undulatus.

    Directory of Open Access Journals (Sweden)

    Partha Bhagavatula

    Full Text Available BACKGROUND: While considerable scientific effort has been devoted to studying how birds navigate over long distances, relatively little is known about how targets are detected, obstacles are avoided and smooth landings are orchestrated. Here we examine how visual features in the environment, such as contrasting edges, determine where a bird will land. METHODOLOGY/PRINCIPAL FINDINGS: Landing in budgerigars (Melopsittacus undulatus was investigated by training them to fly from a perch to a feeder, and video-filming their landings. The feeder was placed on a grey disc that produced a contrasting edge against a uniformly blue background. We found that the birds tended to land primarily at the edge of the disc and walk to the feeder, even though the feeder was in the middle of the disc. This suggests that the birds were using the visual contrast at the boundary of the disc to target their landings. When the grey level of the disc was varied systematically, whilst keeping the blue background constant, there was one intermediate grey level at which the budgerigar's preference for the disc boundary disappeared. The budgerigars then landed randomly all over the test surface. Even though this disc is (for humans clearly distinguishable from the blue background, it offers very little contrast against the background, in the red and green regions of the spectrum. CONCLUSIONS: We conclude that budgerigars use visual edges to target and guide landings. Calculations of photoreceptor excitation reveal that edge detection in landing budgerigars is performed by a color-blind luminance channel that sums the signals from the red and green photoreceptors, or, alternatively, receives input from the red double-cones. This finding has close parallels to vision in honeybees and primates, where edge detection and motion perception are also largely color-blind.

  10. The Inner Urban Edge

    Science.gov (United States)

    Ferebee, Ann; Carpenter, Edward K.

    1974-01-01

    In this article, renewal of the inner urban edge is discussed. Norfolk (Virginia) is attempting to blur the difference between old and new neighbor hoods through zoning and architectural controls. Cincinnati (Ohio) is developing an environmentally sound hillside design. Reading (Pennsylvania) is utilizing old railyards for greenbelts of hiking and…

  11. Levels determination of heavy elements (Fe, Cu, Zn, Pb and Hg) in sword fish caught from the bay of Ghazaouet

    International Nuclear Information System (INIS)

    Chalabi, A.; Malek, M.; Ghomari, M.; Benamar, M.A.; Tchantchane, A.; Azbouche, A.; Toumert, I.; Benouali, N.; Tobbeche, S. , Algiers; Algeria)

    1993-04-01

    The nuclear technics 'PIXE' and 'XRF', were used for heavy metals analysis (Fe, Cu, Zn, Pb, and Hg), in sword fish (xiphias Gladius) caught in Ghazaouet bay. Muscles, liver and gonads were analysed. The methods gave similar results. A bioaccumulation phenomenon was observed except for Hg. The high amount of concentrations found liver, especially in the case of confirms that liver is a storage organ. The high levels of Zn seem to be due to the industrial wastes from the electrolyte plant in the region. All values were lower than the admissible norms

  12. Crossed-swords, capsule-pinch technique for capsulotomy in pediatric and/or loose lens cataract extraction.

    Science.gov (United States)

    Snyder, Michael E; Lindsell, Luke B

    2010-02-01

    Puncturing the anterior capsule in a patient with a very soft lens, an elastic capsule, and/or deficient zonular countertraction can be challenging even with a sharp needle or blade. The crossed-swords, capsule-pinch technique capitalizes on opposing forces from 2 needles directed toward each other with a "pinch" of the capsule between their tips. This affords a controlled and facile puncture of the capsule without creating stress on the zonules or anteroposterior displacement of the lens. Copyright 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  13. ICRF edge modeling

    International Nuclear Information System (INIS)

    1991-01-01

    This report describes the technical progress for the DOE sponsored grant, ''ICRF Edge Modeling.'' An emphasis is placed on the progress since the Technical Progress Report (January 10, 1990) was submitted to the Department of Energy. The design of ICRF antennas for C-Mod and TFTR was investigated during this period. In addition, quasilinear models for electron heating were refined and applied to the design of ICRF antennas. The relevant professional activities sponsored by this grant are given. 4 refs., 11 figs

  14. ICRF edge modeling studies

    Energy Technology Data Exchange (ETDEWEB)

    Lehrman, I.S. (Grumman Corp. Research Center, Princeton, NJ (USA)); Colestock, P.L. (Princeton Univ., NJ (USA). Plasma Physics Lab.)

    1990-04-01

    Theoretical models have been developed, and are currently being refined, to explain the edge plasma-antenna interaction that occurs during ICRF heating. The periodic structure of a Faraday shielded antenna is found to result in strong ponderomotive force in the vicinity of the antenna. A fluid model, which incorporates the ponderomotive force, shows an increase in transport to the Faraday shield. A kinetic model shows that the strong antenna near fields act to increase the energy of deuterons which strike the shield, thereby increasing the sputtering of shield material. Estimates of edge impurity harmonic heating show no significant heating for either in or out-of-phase antenna operation. Additionally, a particle model for electrons near the shield shows that heating results from the parallel electric field associated with the fast wave. A quasilinear model for edge electron heating is presented and compared to the particle calculations. The models' predictions are shown to be consistent with measurements of enhanced transport. (orig.).

  15. Multi-indicator Evaluation System for Broadsword, Rod, Sword and Spear Athletes Based on Analytic Hierarchy Process

    Science.gov (United States)

    Luo, Lin

    2017-08-01

    In the practical selection of Wushu athletes, the objective evaluation of the level of athletes lacks sufficient technical indicators and often relies on the coach’s subjective judgments. It is difficult to accurately and objectively reflect the overall quality of the athletes without a fully quantified indicator system, thus affecting the level improvement of Wushu competition. The analytic hierarchy process (AHP) is a systemic analysis method combining quantitative and qualitative analysis. This paper realizes structured, hierarchized and quantified decision-making process of evaluating broadsword, rod, sword and spear athletes in the AHP. Combing characteristics of the athletes, analysis is carried out from three aspects, i.e., the athlete’s body shape, physical function and sports quality and 18 specific evaluation indicators established, and then combining expert advice and practical experience, pairwise comparison matrix is determined, and then the weight of the indicators and comprehensive evaluation coefficient are obtained to establish the evaluation model for the athletes, thus providing a scientific theoretical basis for the selection of Wushu athletes. The evaluation model proposed in this paper has realized the evaluation system of broadsword, rod, sword and spear athletes, which has effectively improved the scientific level of Wushu athletes selection in practical application.

  16. Double Trouble

    NARCIS (Netherlands)

    Elsaesser, Thomas; Kievit, Robert; Simons, Jan

    1994-01-01

    Double Trouble highlights the career of Dutch scriptwriter and television producer Chiem van Houweninge, well-known for his long-running TV comedy series and as author of episodes for TV detective series. Double Trouble gives Van Houweninge's own views on writing and filming in television prime

  17. Smoothness in Binomial Edge Ideals

    Directory of Open Access Journals (Sweden)

    Hamid Damadi

    2016-06-01

    Full Text Available In this paper we study some geometric properties of the algebraic set associated to the binomial edge ideal of a graph. We study the singularity and smoothness of the algebraic set associated to the binomial edge ideal of a graph. Some of these algebraic sets are irreducible and some of them are reducible. If every irreducible component of the algebraic set is smooth we call the graph an edge smooth graph, otherwise it is called an edge singular graph. We show that complete graphs are edge smooth and introduce two conditions such that the graph G is edge singular if and only if it satisfies these conditions. Then, it is shown that cycles and most of trees are edge singular. In addition, it is proved that complete bipartite graphs are edge smooth.

  18. The edges of understanding

    Directory of Open Access Journals (Sweden)

    Lander Arthur D

    2010-04-01

    Full Text Available Abstract A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was the double helix. In the present, post-modern, 'systems biology' era, however, it is, arguably, the hairball.

  19. The edges of understanding.

    Science.gov (United States)

    Lander, Arthur D

    2010-04-12

    A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was the double helix. In the present, post-modern, 'systems biology' era, however, it is, arguably, the hairball.

  20. The edges of understanding

    OpenAIRE

    Lander Arthur D

    2010-01-01

    Abstract A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was the double helix. In the present, post-modern, 'systems biology' era, however, it is, arguably, the hairball.

  1. Faced with a double-edged risk: Ugandan university students ...

    African Journals Online (AJOL)

    EC) have information and access to emergency contraceptive pills (ECPs), it has remained secretive in low-income countries like Uganda. Although several studies have been conducted in relation to EC, few have addressed users' perceptions ...

  2. The Double-Edged Effects of Social Media Terror Communication

    DEFF Research Database (Denmark)

    Nickel, Sandro

    2014-01-01

    This paper connects the effects of social media on terror/anti-terror communication with dynamics and consequences of surveillance. Citizens become via social media more independent from mass media and more interconnected. This is also valid when citizens engage in terror/anti-terror communication...... that social media contribute to extending surveillance: by being a temptation for intelligence services, by not resisting state authorities and via constructing threat perceptions among populations which in effect deliver security politicians ‘windows of opportunity’ in order to implement ever more....... However, via social media citizens also become targets of the ‘collect-it-all’ surveillance, which was revealed to the global public in 2013. I argue that due to such surveillance some citizens might start to censor themselves and that surveillance inflicts with a number of human rights. I further argue...

  3. Competing edge networks

    Science.gov (United States)

    Parsons, Mark; Grindrod, Peter

    2012-06-01

    We introduce a model for a pair of nonlinear evolving networks, defined over a common set of vertices, subject to edgewise competition. Each network may grow new edges spontaneously or through triad closure. Both networks inhibit the other's growth and encourage the other's demise. These nonlinear stochastic competition equations yield to a mean field analysis resulting in a nonlinear deterministic system. There may be multiple equilibria; and bifurcations of different types are shown to occur within a reduced parameter space. This situation models competitive communication networks such as BlackBerry Messenger displacing SMS; or instant messaging displacing emails.

  4. Degenerate band edge laser

    Science.gov (United States)

    Veysi, Mehdi; Othman, Mohamed A. K.; Figotin, Alexander; Capolino, Filippo

    2018-05-01

    We propose a class of lasers based on a fourth-order exceptional point of degeneracy (EPD) referred to as the degenerate band edge (DBE). EPDs have been found in parity-time-symmetric photonic structures that require loss and/or gain; here we show that the DBE is a different kind of EPD since it occurs in periodic structures that are lossless and gainless. Because of this property, a small level of gain is sufficient to induce single-frequency lasing based on a synchronous operation of four degenerate Floquet-Bloch eigenwaves. This lasing scheme constitutes a light-matter interaction mechanism that leads also to a unique scaling law of the laser threshold with the inverse of the fifth power of the laser-cavity length. The DBE laser has the lowest lasing threshold in comparison to a regular band edge laser and to a conventional laser in cavities with the same loaded quality (Q ) factor and length. In particular, even without mirror reflectors the DBE laser exhibits a lasing threshold which is an order of magnitude lower than that of a uniform cavity laser of the same length and with very high mirror reflectivity. Importantly, this novel DBE lasing regime enforces mode selectivity and coherent single-frequency operation even for pumping rates well beyond the lasing threshold, in contrast to the multifrequency nature of conventional uniform cavity lasers.

  5. Cheating on the edge.

    Directory of Open Access Journals (Sweden)

    Lee Alan Dugatkin

    2008-07-01

    Full Text Available We present the results of an individual agent-based model of antibiotic resistance in bacteria. Our model examines antibiotic resistance when two strategies exist: "producers"--who secrete a substance that breaks down antibiotics--and nonproducers ("cheats" who do not secrete, or carry the machinery associated with secretion. The model allows for populations of up to 10,000, in which bacteria are affected by their nearest neighbors, and we assume cheaters die when there are no producers in their neighborhood. Each of 10,000 slots on our grid (a torus could be occupied by a producer or a nonproducer, or could (temporarily be unoccupied. The most surprising and dramatic result we uncovered is that when producers and nonproducers coexist at equilibrium, nonproducers are almost always found on the edges of clusters of producers.

  6. Challenges in edge modeling

    International Nuclear Information System (INIS)

    Schneider, R.

    2007-01-01

    Fluid models like B2, UEDGE or EDGE2D are the working horses for scrape-off layer physics, both for design and experimental support. The concept of a numerical tokamak, aiming at a predictive code for ITER, triggers the need to re-assess the available tools and their necessary extensions. These additional physics issues will be summarized from a personal point-of-view. Depending on the specific problem, several complexity levels of scrape-off layer models will be needed. Therefore, a hierarchy of tools is necessary, which will be discussed. Furthermore, the experience existing in other scientific fields with multi-scale problems and modeling should be used. Here, the coupling of different length and time scales are in particular of interest for fusion problems. (author)

  7. Edge remap for solids

    Energy Technology Data Exchange (ETDEWEB)

    Kamm, James R.; Love, Edward; Robinson, Allen C; Young, Joseph G.; Ridzal, Denis

    2013-12-01

    We review the edge element formulation for describing the kinematics of hyperelastic solids. This approach is used to frame the problem of remapping the inverse deformation gradient for Arbitrary Lagrangian-Eulerian (ALE) simulations of solid dynamics. For hyperelastic materials, the stress state is completely determined by the deformation gradient, so remapping this quantity effectively updates the stress state of the material. A method, inspired by the constrained transport remap in electromagnetics, is reviewed, according to which the zero-curl constraint on the inverse deformation gradient is implicitly satisfied. Open issues related to the accuracy of this approach are identified. An optimization-based approach is implemented to enforce positivity of the determinant of the deformation gradient. The efficacy of this approach is illustrated with numerical examples.

  8. Playing on the edge

    DEFF Research Database (Denmark)

    Cermak-Sassenrath, Daniel

    2018-01-01

    and specific ways. For instance, gambling for money, party and drinking games, professional play and show sports, art installations, violent and military propaganda computer games, pervasive/mobile gaming, live-action role playing, festivals, performances, and games such as Ghosting and Planking. It is argued......Everything gets more interesting, challenging, or intense the closer it gets to the edge, and so does play. How edgy can play become and still be play? Based on Huizinga’s notion of play, this chapter discusses how a wide range of playful activities pushes the boundaries of play in different...... that in concert with a number of characteristics that mark an activity as play, play is essentially a subjective perspective and individual decision of the player. Huizinga calls this attitude the play spirit, which informs a player’s actions and is in turn sustained by them. Edgy digital or mobile games do...

  9. Competing edge networks

    International Nuclear Information System (INIS)

    Parsons, Mark; Grindrod, Peter

    2012-01-01

    We introduce a model for a pair of nonlinear evolving networks, defined over a common set of vertices, subject to edgewise competition. Each network may grow new edges spontaneously or through triad closure. Both networks inhibit the other's growth and encourage the other's demise. These nonlinear stochastic competition equations yield to a mean field analysis resulting in a nonlinear deterministic system. There may be multiple equilibria; and bifurcations of different types are shown to occur within a reduced parameter space. This situation models competitive communication networks such as BlackBerry Messenger displacing SMS; or instant messaging displacing emails. -- Highlights: ► A model for edgewise-competing evolving network pairs is introduced. ► Defined competition equations yield to a mean field analysis. ► Multiple equilibrium states and different bifurcation types can occur. ► The system is sensitive to sparse initial conditions and near unstable equilibriums.

  10. Imaging properties of the light sword optical element used as a contact lens in a presbyopic eye model.

    Science.gov (United States)

    Petelczyc, K; Bará, S; Lopez, A Ciro; Jaroszewicz, Z; Kakarenko, K; Kolodziejczyk, A; Sypek, M

    2011-12-05

    The paper analyzes the imaging properties of the light sword optical element (LSOE) applied as a contact lens to the presbyopic human eye. We performed our studies with a human eye model based on the Gullstrand parameterization. In order to quantify the discussion concerning imaging with extended depth of focus, we introduced quantitative parameters characterizing output images of optotypes obtained in numerical simulations. The quality of the images formed by the LSOE were compared with those created by a presbyopic human eye, reading glasses and a quartic inverse axicon. Then we complemented the numerical results by an experiment where a 3D scene was imaged by means of the refractive LSOE correcting an artificial eye based on the Gullstrand model. According to performed simulations and experiments the LSOE exhibits abilities for presbyopia correction in a wide range of functional vision distances.

  11. Exclusive contracts in the hospital setting: a two-edged sword: part 2: pros and cons, avoidance strategies, and negotiating tips.

    Science.gov (United States)

    Portman, Robert M

    2007-06-01

    Hospitals routinely enter into contracts with radiology groups for the right to be the exclusive providers of radiologic services at the facilities in exchange for the groups' agreeing to provide and manage all aspects of those services within the hospitals. These exclusive contracts generally result in radiology departments and associated equipment being closed off to physicians who are not part of the contracting groups. Although exclusive contracts offer obvious benefits to the physicians who receive them and obvious disadvantages for those who are excluded, they also present pitfalls for physicians in the chosen group. Part 1 of this article discussed the legal issues raised by exclusive contracts. Part 2 weighs the practical advantages and disadvantages of exclusive contracts for physicians covered and not covered by such contracts and strategies for avoiding them, as well as provisions that can be included in medical staff bylaws to protect physicians from the automatic termination of privileges when a hospital enters into or terminates an exclusive contract. The remainder of the article provides tips on specific provisions of exclusive contracts that should be included or avoided.

  12. The effects of yellow soybean, black soybean, and sword bean on lipid levels and oxidative stress in ovariectomized rats.

    Science.gov (United States)

    Byun, Jae Soon; Han, Young Sun; Lee, Sang Sun

    2010-04-01

    Soy isoflavones have been reported to decrease the risk of atherosclerosis in postmenopausal women. However, the effects of dietary consumption of soybean have not been explored. In this study, we evaluated the effects of consuming yellow soybeans, black soybeans (Glycine max), or sword beans (Canavalia gladiate) on lipid and oxidative stress levels in an ovariectomized rat model. Forty-seven nine-week-old female rats were ovariectomized, randomly divided into four groups, and fed one of the following diets for 10 weeks: a diet supplemented with casein (NC, n = 12), a diet supplemented with yellow soybean (YS, n = 12), a diet supplemented with black soybean (BS, n = 12), or a diet supplemented with sword bean (SB, n = 11). Plasma triglyceride (TG) levels in the BS and SB groups were significantly lower than that in the NC group. Notably, the BS group had significantly lower plasma total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels than the other groups. Hepatic total lipid levels were significantly lower in the YS and SB groups, and cholesterol levels were significantly lower in the SB group than in the NC group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher in the groups fed beans compared to the NC group. Hepatic thiobarbituric acid reactive substances (TBARS) levels were also significantly lower in the BS and SB groups than the NC group. In conclusion, our results suggest that consumption of various types of beans may inhibit oxidative stress in postmenopausal women by increasing antioxidant activity and improving lipid profiles. Notably, intake of black soybean resulted in the greatest improvement in risk factors associated with cardiovascular disease.

  13. Resolving the chemical structures of off-odorants and potentially harmful substances in toys-example of children's swords.

    Science.gov (United States)

    Denk, Philipp; Velasco-Schön, Cristina; Buettner, Andrea

    2017-09-01

    Most children's toys on the market are primarily made out of plastic and other complex composite materials. Consumer complaints about offensive odors or irritating effects associated with toy products have increased in recent years. One example is the strongly perceivable negative odor reported for a particular series of toy swords. Characterizing the presence of contaminants, including those that have the potential to be deleterious to health, in such products is a significant analytical challenge due to the high baseline abundance of chemical constituents of the materials used in the products. In the present study, the nature of offensive odorants associated with toy sword products was examined by gas chromatography (GC). After initial sensory evaluations, the volatile compounds from the toy products were recovered using solvent extraction and solvent-assisted flavor evaporation. The extracts were analyzed using GC-olfactometry (GC-O) and two-dimensional GC-O coupled with mass spectrometry (GC-GC-MS/O). A total of 26 odor-active compounds, including aromatic hydrocarbons and phenols, were identified among numerous non-odorous volatile by-products. These substances also included polycyclic aromatic hydrocarbons, which were analyzed by GC-MS. Representative substances were naphthalene and 1,2-dihydronaphthalene that exhibited moldy, mothball-like odor impressions, and phenol derivatives with leather-like, phenolic, horse-stable-like smells. The odorants detected correlated with the assigned attributes from the sensory analyses. This study clearly shows that the detection and identification of such odorous contaminants can provide key indications of potentially harmful yet unknown substances in everyday products such as toys. Graphical abstract ᅟ.

  14. Double layers above the aurora

    International Nuclear Information System (INIS)

    Temerin, M.; Mozer, F.S.

    1987-01-01

    Two different kinds of double layers were found in association with auroral precipitation. One of these is the so-called electrostatic shock, which is oriented at an oblique angle to the magnetic field in such a way that the perpendicular electric field is much larger than the parallel electric field. This type of double layer is often found at the edges of regions of upflowing ion beams and the direction of the electric fields in the shock points toward the ion beam. The potential drop through the shock can be several kV and is comparable to the total potential needed to produce auroral acceleration. Instabilities associated with the shock may generate obliquely propagating Alfven waves, which may accelerate electrons to produce flickering auroras. The flickering aurora provides evidence that the electrostatic shock may have large temporal fluctuations. The other kind of double layer is the small-amplitude double layer found in regions of upward flowing in beams, often in association with electrostatic ion cyclotron waves. The parallel and perpendicular electric fields in these structures are comparable in magnitude. The associated potentials are a few eV. Since many such double layers are found in regions of upward flowing ion beams, the combined potential drop through a set of these double layers can be substantial

  15. Cutting Edge Localisation in an Edge Profile Milling Head

    NARCIS (Netherlands)

    Fernandez Robles, Laura; Azzopardi, George; Alegre, Enrique; Petkov, Nicolai

    2015-01-01

    Wear evaluation of cutting tools is a key issue for prolonging their lifetime and ensuring high quality of products. In this paper, we present a method for the effective localisation of cutting edges of inserts in digital images of an edge profile milling head. We introduce a new image data set of

  16. Commentary: Hyperbaric oxygen treatment for wounds - evidence and the Sword of Damocles.

    Science.gov (United States)

    Laden, Gerard

    2015-12-01

    Increased access to any treatment sensibly follows the clinical and cost benefit being established. For many treatments this requires multiple, high-quality clinical trials and supporting cost analysis. Cost analysis may be applied to a single treatment or used to compare two or more treatments. Clinical efficacy and cost benefit are best scrutinised and validated by publication in the peer-reviewed literature. True peer review is most effectively achieved 'after publication' by the wider scientific community, i.e., the journal readers. However, initially an editor, usually advised by referees, is asked to make a judgment on a paper's suitability for publication. It follows that medical journals are in a position of power and responsibility. Researchers and editors know publications are currency; effectively they are the equivalent of academic bitcoins. Regarding the paper in this issue by Santema et al., the same authors, in designing a prospective randomised controlled trial (RCT) of the role of hyperbaric oxygen treatment (HBOT) in diabetic wounds, included the name "Damocles" in that trial's title. Readers will perhaps appreciate from my comments below as a referee for the Santema et al. paper, that behind the scenes "the Sword of Damocles" (an allusion to the imminent and ever-present peril faced by those in positions of power) hangs over researchers, treating physician, journal editors and referees alike. Whilst positive about its content, upon reflection, my concern was the anticipated reception of this paper by the journal readership. This is, of course, a matter for the Editor; however, herewith is my reasoning. Further to the body of published work by Bennett et al., and others that has focused attention on the lack of good quality evidence for the use of HBOT for most indications, I think this regrettable state of affairs is now both known and accepted by mainstream healthcare purchasers and providers. I speculate that all these bodies already

  17. Edge instabilities of topological superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, Johannes S. [Institut fuer Theoretische Physik und Astrophysik, Universitaet Wuerzburg (Germany); Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany); Assaad, Fakher F. [Institut fuer Theoretische Physik und Astrophysik, Universitaet Wuerzburg (Germany); Schnyder, Andreas P. [Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany)

    2016-07-01

    Nodal topological superconductors display zero-energy Majorana flat bands at generic edges. The flatness of these edge bands, which is protected by time-reversal and translation symmetry, gives rise to an extensive ground state degeneracy and a diverging density of states. Therefore, even arbitrarily weak interactions lead to an instability of the flat-band edge states towards time-reversal and translation-symmetry broken phases, which lift the ground-state degeneracy. Here, we employ Monte Carlo simulations combined with mean-field considerations to examine the instabilities of the flat-band edge states of d{sub xy}-wave superconductors. We find that attractive interactions induce a complex s-wave pairing instability together with a density wave instability. Repulsive interactions, on the other hand, lead to ferromagnetism mixed with spin-triplet pairing at the edge. We discuss the implications of our findings for experiments on cuprate high-temperature superconductors.

  18. Origin of spin-polarization in edge boron doped zigzag graphene nanoribbon: a potential spin filter.

    Science.gov (United States)

    Chakrabarty, Soubhik; Wasey, A H M Abdul; Thapa, Ranjit; Das, Gour Prasad

    2018-06-04

    To realize the graphene based spintronic device the prime challenge is to control the electronic structure of edges. In this work we find the origin of spin filtering property in edge boron doped zigzag graphene nanoribbon (ZGNRs) and provide a guide to prepare the graphene based next generation spin filter based device. Here we unveil the role of orbital (p-electron) to tune the electronic, magnetic and transport properties of the edge B doped ZGNRs. When all the edge carbon atoms at one of the edges of ZGNRs are replaced by B (100% edge B-doping), the system undergoes semiconductor to metal transition. The role of passivation of the edge with single/double atomic hydrogen on the electronic properties and its relation with the p electron is correlated in-depth. 50% edge B-doped ZGNRs (50% of the edge C atoms at one of the edges are replaced by B) also shows half-metallicity when the doped edge is left unpassivated. The half-metallic systems show 100% spin-filtering efficiency for a wide range of bias voltages. Zero bias transmission function of the other configurations shows asymmetric behavior for the up and down spin channels, thereby indicating their possible application potential in nano-spintronics. © 2018 IOP Publishing Ltd.

  19. Double Chooz

    Energy Technology Data Exchange (ETDEWEB)

    Buck, Christian [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany)

    2006-05-15

    The goal of the Double Chooz reactor neutrino experiment is to search for the neutrino mixing parameter {theta}{sub 13}. Double Chooz will use two identical detectors at 150 m and 1.05 km distance from the reactor cores. The near detector is used to monitor the reactor {nu}-bar {sub e} flux while the second is dedicated to the search for a deviation from the expected (1/distance){sup 2} behavior. This two detector concept will allow a relative normalization systematic error of ca. 0.6 %. The expected sensitivity for sin{sup 2}2{theta}{sub 13} is then in the range 0.02 - 0.03 after three years of data taking. The antineutrinos will be detected in a liquid scintillator through the capture on protons followed by a gamma cascade, produced by the neutron capture on Gd.

  20. Double supergeometry

    Energy Technology Data Exchange (ETDEWEB)

    Cederwall, Martin [Division for Theoretical Physics, Department of Physics, Chalmers University of Technology,SE 412 96 Gothenburg (Sweden)

    2016-06-27

    A geometry of superspace corresponding to double field theory is developed, with type I I supergravity in D=10 as the main example. The formalism is based on an orthosymplectic extension OSp(d,d|2s) of the continuous T-duality group. Covariance under generalised super-diffeomorphisms is manifest. Ordinary superspace is obtained as a solution of the orthosymplectic section condition. A systematic study of curved superspace Bianchi identities is performed, and a relation to a double pure spinor superfield cohomology is established. A Ramond-Ramond superfield is constructed as an infinite-dimensional orthosymplectic spinor. Such objects in minimal orbits under the OSp supergroup (“pure spinors”) define super-sections.

  1. Double ambidexterity

    DEFF Research Database (Denmark)

    Kaulio, Matti; Thorén, Kent; Rohrbeck, René

    2017-01-01

    We leverage the business model innovation and ambidexterity literature to investigate a contradictory case, the Swedish-Finnish Telecom operator TeliaSonera. Despite being challenged by three major disruptions, the company not only still exists but also enjoys remarkably good financial performance....... Building on extant archival data and interviews, we carefully identify and map 26 organizational responses during 1992–2016. We find that the firm has overcome three critical phases by experimenting and pioneering with portfolios of business models and/or technological innovations. We describe...... this behaviour as double ambidexterity. We use an in-depth case study to conceptualize double ambidexterity and discuss its impact on the business's survival and enduring success....

  2. On the edge between tradition and innovation

    DEFF Research Database (Denmark)

    Marchetti, Emanuela; Nandhakumar, Joe

    2011-01-01

    system of values, creating a “double bind” dynamics (Bateson 1972), which denies a clear way to succeed in achieving innovation and a new organizational identity. Therefore, innovation practices are confined within safe spaces, that we call innovation enclosures, such as temporary/thematic exhibitions...... cannot succeed, if it is not supported by a favourable global network, providing a negotiation space (Law and Callon 1992). Starting from this theory, we analyze the case of two local museums, in order to gain insights into museum innovation and the emerging interplay with traditional practices. We...... investigate also how external pressure from a network, apparently supporting innovation, may instead create a conflicting system of values, compromising the emergence of a negotiation space and hindering the innovation process. Our study suggests that museum innovation is still unsettled, on the edge between...

  3. The Two Edge Knife of Decentralization

    Directory of Open Access Journals (Sweden)

    Ahmad Khoirul Umam

    2011-07-01

    Full Text Available A centralistic government model has become a trend in a number of developing countries, in which the ideosycretic aspect becomes pivotal key in the policy making. The situation constitutes authoritarianism, cronyism, and corruption. To break the impasse, the decentralized system is proposed to make people closer to the public policy making. Decentralization is also convinced to be the solution to create a good governance. But a number of facts in the developing countries demonstrates that decentralization indeed has ignite emerges backfires such as decentralized corruption, parochialism, horizontal conflict, local political instability and others. This article elaborates the theoretical framework on decentralization's ouput as the a double-edge knife. In a simple words, the concept of decentralization does not have a permanent relationship with the creation of good governance and development. Without substantive democracy, decentralization is indeed potential to be a destructive political instrument threating the state's future.

  4. The edge of space time

    International Nuclear Information System (INIS)

    Hawking, S.

    1993-01-01

    What happened at the beginning of the expansion of the universe. Did space time have an edge at the Big Bang. The answer is that, if the boundary conditions of the universe are that it has no boundary, time ceases to be well-defined in the very early universe as the direction ''north'' ceases to be well defined at the North Pole of the Earth. The quantity that we measure as time has a beginning but that does not mean spacetime has an edge, just as the surface of the Earth does not have an edge at the North Pole. 8 figs

  5. Reduction of airfoil trailing edge noise by trailing edge blowing

    International Nuclear Information System (INIS)

    Gerhard, T; Carolus, T; Erbslöh, S

    2014-01-01

    The paper deals with airfoil trailing edge noise and its reduction by trailing edge blowing. A Somers S834 airfoil section which originally was designed for small wind turbines is investigated. To mimic realistic Reynolds numbers the boundary layer is tripped on pressure and suction side. The chordwise position of the blowing slot is varied. The acoustic sources, i.e. the unsteady flow quantities in the turbulent boundary layer in the vicinity of the trailing edge, are quantified for the airfoil without and with trailing edge blowing by means of a large eddy simulation and complementary measurements. Eventually the far field airfoil noise is measured by a two-microphone filtering and correlation and a 40 microphone array technique. Both, LES-prediction and measurements showed that a suitable blowing jet on the airfoil suction side is able to reduce significantly the turbulence intensity and the induced surface pressure fluctuations in the trailing edge region. As a consequence, trailing edge noise associated with a spectral hump around 500 Hz could be reduced by 3 dB. For that a jet velocity of 50% of the free field velocity was sufficient. The most favourable slot position was at 90% chord length

  6. Diffraction at a Straight Edge

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 5. Diffraction at a Straight Edge: A Gem from Sommerfeld's Work in Classical Physics. Rajaram Nityananda. General Article Volume 20 Issue 5 May 2015 pp 389-400 ...

  7. DAVs: Red Edge and Outbursts

    Science.gov (United States)

    Luan, Jing

    2018-04-01

    As established by ground based surveys, white dwarfs with hydrogen atmospheres pulsate as they cool across the temperature range, 12500Kred edge is a two-decade old puzzle. Recently, Kepler discovered a number of cool DAVs exhibiting sporadic outbursts separated by days, each lasting several hours, and releasing \\sim 10^{33}-10^{34} {erg}. We provide quantitative explanations for both the red edge and the outbursts. The minimal frequency for overstable modes rises abruptly near the red edge. Although high frequency overstable modes exist below the red edge, their photometric amplitudes are generally too small to be detected by ground based observations. Nevertheless, these overstable parent modes can manifest themselves through nonlinear mode couplings to damped daughter modes which generate limit cycles giving rise to photometric outbursts.

  8. Edge Fracture in Complex Fluids.

    Science.gov (United States)

    Hemingway, Ewan J; Kusumaatmaja, Halim; Fielding, Suzanne M

    2017-07-14

    We study theoretically the edge fracture instability in sheared complex fluids, by means of linear stability analysis and direct nonlinear simulations. We derive an exact analytical expression for the onset of edge fracture in terms of the shear-rate derivative of the fluid's second normal stress difference, the shear-rate derivative of the shear stress, the jump in shear stress across the interface between the fluid and the outside medium (usually air), the surface tension of that interface, and the rheometer gap size. We provide a full mechanistic understanding of the edge fracture instability, carefully validated against our simulations. These findings, which are robust with respect to choice of rheological constitutive model, also suggest a possible route to mitigating edge fracture, potentially allowing experimentalists to achieve and accurately measure flows stronger than hitherto possible.

  9. Edge of polar cap patches

    Science.gov (United States)

    Hosokawa, K.; Taguchi, S.; Ogawa, Y.

    2016-04-01

    On the night of 4 December 2013, a sequence of polar cap patches was captured by an all-sky airglow imager (ASI) in Longyearbyen, Norway (78.1°N, 15.5°E). The 630.0 nm airglow images from the ASI of 4 second exposure time, oversampled the emission of natural lifetime (with quenching) of at least ˜30 sec, introduce no observational blurring effects. By using such high-quality ASI images, we succeeded in visualizing an asymmetry in the gradients between the leading/trailing edges of the patches in a 2-D fashion. The gradient in the leading edge was found to be 2-3 times steeper than that in the trailing edge. We also identified fingerlike structures, appearing only along the trailing edge of the patches, whose horizontal scale size ranged from 55 to 210 km. These fingers are considered to be manifestations of plasma structuring through the gradient-drift instability (GDI), which is known to occur only along the trailing edge of patches. That is, the current 2-D observations visualized, for the first time, how GDI stirs the patch plasma and such a mixing process makes the trailing edge more gradual. This result strongly implies a close connection between the GDI-driven plasma stirring and the asymmetry in the large-scale shape of patches and then suggests that the fingerlike structures can be used as markers to estimate the fine-scale structure in the plasma flow within patches.

  10. Protected Edge Modes without Symmetry

    Directory of Open Access Journals (Sweden)

    Michael Levin

    2013-05-01

    Full Text Available We discuss the question of when a gapped two-dimensional electron system without any symmetry has a protected gapless edge mode. While it is well known that systems with a nonzero thermal Hall conductance, K_{H}≠0, support such modes, here we show that robust modes can also occur when K_{H}=0—if the system has quasiparticles with fractional statistics. We show that some types of fractional statistics are compatible with a gapped edge, while others are fundamentally incompatible. More generally, we give a criterion for when an electron system with Abelian statistics and K_{H}=0 can support a gapped edge: We show that a gapped edge is possible if and only if there exists a subset of quasiparticle types M such that (1 all the quasiparticles in M have trivial mutual statistics, and (2 every quasiparticle that is not in M has nontrivial mutual statistics with at least one quasiparticle in M. We derive this criterion using three different approaches: a microscopic analysis of the edge, a general argument based on braiding statistics, and finally a conformal field theory approach that uses constraints from modular invariance. We also discuss the analogous result for two-dimensional boson systems.

  11. All-graphene edge contacts

    DEFF Research Database (Denmark)

    Jacobsen, Kåre Wedel; Falkenberg, Jesper Toft; Papior, Nick Rübner

    2016-01-01

    Using ab-initio methods we investigate the possibility of three-terminalgraphene "T-junction" devices and show that these all-graphene edge contactsare energetically feasible when the 1D interface itself is free from foreignatoms. We examine the energetics of various junction structures as a func......Using ab-initio methods we investigate the possibility of three-terminalgraphene "T-junction" devices and show that these all-graphene edge contactsare energetically feasible when the 1D interface itself is free from foreignatoms. We examine the energetics of various junction structures...... to be in therange of 1-10 kΩμm which is comparable to the best contact resistance reportedfor edge-contacted graphene-metal contacts. We conclude that conductingall-carbon T-junctions should be feasible....

  12. Improving color constancy by photometric edge weighting

    NARCIS (Netherlands)

    Gijsenij, A.; Gevers, T.; van de Weijer, J.

    2012-01-01

    Edge-based color constancy methods make use of image derivatives to estimate the illuminant. However, different edge types exist in real-world images, such as material, shadow, and highlight edges. These different edge types may have a distinctive influence on the performance of the illuminant

  13. X-ray absorption near edge spectroscopy at the Mn K-edge in highly homogeneous GaMnN diluted magnetic semiconductors

    Energy Technology Data Exchange (ETDEWEB)

    Sancho-Juan, O.; Cantarero, A.; Garro, N.; Cros, A. [Materials Science Institute, University of Valencia, PO Box 22085, 46071 Valencia (Spain); Martinez-Criado, G.; Salome, M.; Susini, J. [ESRF, Polygone Scientifique Louis Neel, 6 rue Jules Horowitz, 38000 Grenoble (France); Olguin, D. [Dept. de Fisica, CINVESTAV-IPN, 07300 Mexico D.F. (Mexico); Dhar, S.; Ploog, K. [Paul Drude Institute, Hausvogteiplatz 5-7, 10117 Berlin (Germany)

    2006-06-15

    We have studied by X-ray absorption spectroscopy the local environment of Mn in highly homogeneous Ga{sub 1-x}Mn{sub x}N (0.06edges. In this report, we focus our attention to the X-ray absorption near edge spectroscopy (XANES) results. The comparison of the XANES spectra corresponding to the Ga and Mn edges indicates that Mn is substitutional to Ga in all samples studied. The XANES spectra measured at the Mn absorption edge shows in the near-edge region a double peak and a shoulder below the absorption edge and the main absorption peak after the edge, separated around 15 eV above the pre-edge structure. We have compared the position of the edge with that of MnO (Mn{sup 2+}) and Mn{sub 2}O{sub 3} (Mn{sup 3+}). All samples studied present the same Mn oxidation state, 2{sup +}. In order to interprete the near-edge structure, we have performed ab initio calculations with a 2 x 2 x 1supercell ({proportional_to}6% Mn) using the full potential linear augmented plane wave method as implemented in the Wien2k code. The calculations show the appearance of Mn anti-bonding t{sub 2g} bands, which are responsible for the pre-edge absorption. The shoulder and main absorption peaks are due to transitions from the valence band 1s-states of Mn to the p-contributions of the conduction bands. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  14. The knife-edge chamber

    International Nuclear Information System (INIS)

    Barasch, E.F.; Bowcock, T.J.V.; Drew, M.M.; Elliott, S.M.; Lee, B.; McIntyre, P.M.; Pang, Y.; Popovic, M.; Smith, D.D.

    1990-01-01

    In this paper the design for a new technology for particle track detectors is described. Using standard IC fabrication techniques, a pattern of microscopic knife edges and field-shaping electrodes can be fabricated on a silicon substrate. The knife-edge chamber uniquely offers attractive performance for the track chambers required for SSC detectors, for which no present technology is yet satisfactory. Its features include: excellent radiation hardness (10 Mrad), excellent spatial resolution (∼20 μm), short drift time (20 ns), and large pulse height (1 mV)

  15. "Meniscus Sign" to Identify the Lenticule Edge in Small-Incision Lenticule Extraction.

    Science.gov (United States)

    Titiyal, Jeewan S; Kaur, Manpreet; Brar, Anand S; Falera, Ruchita

    2018-06-01

    To describe our technique of lenticule edge identification in small-incision lenticule extraction using the "meniscus sign" to prevent lenticule misdissection. Femtosecond laser application for small-incision lenticule extraction was performed. A "double ring" was visible, signifying the edge of the cap cut (outer ring) and lenticule cut (inner ring). The anterior and posterior lamellar planes were delineated in 2 different directions. During creation of the posterior lamellar channel, the lenticule edge was slightly pushed away from the surgeon to create a gap between the inner ring (diameter of the lenticule cut) and the lenticule edge. The lenticule edge assumed a frilled wavy appearance, and the meniscus sign was observed as a gap between the lenticule edge and the inner ring. The meniscus-shaped gap served as a landmark to identify the lenticule edge, and the relationship between the frilled lenticule edge and surgical instruments further acted as a guide to identify the correct plane of dissection. This technique was successfully undertaken in 50 eyes of 25 patients. The meniscus sign was observed in all cases, and no case had cap lenticular adhesions. The meniscus sign helps to identify the lenticule edge and correct dissection planes and provides a visual landmark during the entire surgical procedure.

  16. Carbon distribution during plasma detachment triggered by edge magnetic island formation in LHD

    International Nuclear Information System (INIS)

    Dong, C.F.; Morita, S.; Kobayashi, M.; Oishi, T.; Goto, M.; Wang, E.H.; Huang, X.L.

    2013-01-01

    The detached plasma has been successfully achieved by applying the edge 1/1 magnetic island in Large Helical Device (LHD). Carbon, which is uniquely the dominant intrinsic impurity in general LHD discharges, is considered to be the main radiating species in the island-triggered detached plasma. The vertical profile of CIV measured from general discharges of LHD is characterized by a single edge intensity peak. In detached plasmas triggered by the edge magnetic island formation, however, the vertical profile of CIV shows a significant difference. Double edge peaks of CIV are found during the plasma detachment and the CIV radiation is also remarkably enhanced in the vicinity of X-point, whereas the vertical profile of CVI does not show any significant difference in both the attached and detached plasmas. In this proceeding the carbon distribution during the plasma detachment is presented and the results are discussed with edge magnetic field structure. (author)

  17. At the edge of intonation

    DEFF Research Database (Denmark)

    Niebuhr, Oliver

    2012-01-01

    The paper is concerned with the 'edge of intonation' in a twofold sense. It focuses on utterance-final F0 movements and crosses the traditional segment-prosody divide by investigating the interplay of F0 and voiceless fricatives in speech production. An experiment was performed for German with four...

  18. Capillary Sharp Inner Edge Manufacturing

    Czech Academy of Sciences Publication Activity Database

    Hošek, Jan; Studenovský, K.; Najdek, D.

    2009-01-01

    Roč. 19, č. 35 (2009), s. 19-25 ISSN 1584-5982. [MECAHITECH 09 /1./. Bukurešť, 08.10.2009-09.10.2009] R&D Projects: GA AV ČR IAA200760905 Institutional research plan: CEZ:AV0Z20760514 Keywords : capillary * edge * manufacturing Subject RIV: JR - Other Machinery

  19. Development of edge effects around experimental ecosystem hotspots is affected by edge density and matrix type

    Science.gov (United States)

    Ecological edge effects are sensitive to landscape context. In particular, edge effects can be altered by matrix type and by the presence of other nearby edges. We experimentally altered patch configurations in an African savanna to determine how edge density and matrix type influence edge effect de...

  20. Double inflation

    International Nuclear Information System (INIS)

    Silk, J.; Turner, M.S.

    1986-04-01

    The Zel'dovich spectrum of adiabatic density perturbations is a generic prediction of inflation. There is increasing evidence that when the spectrum is normalized by observational data on small scales, there is not enough power on large scales to account for the observed large-scale structure in the Universe. Decoupling the spectrum on large and small scales could solve this problem. As a means of decoupling the large and small scales we propose double inflation (i.e., two episodes of inflation). In this scenario the spectrum on large scales is determined by the first episode of inflation and those on small scales by a second episode of inflation. We present three models for such a scenario. By nearly saturating the large angular-scale cosmic microwave anisotropy bound, we can easily account for the observed large-scale structure. We take the perturbations on small scales to be very large, deltarho/rho approx. = 0.1 to 0.01, which results in the production of primordial black holes (PBHs), early formation of structure, reionization of the Universe, and a rich array of astrophysical events. The Ω-problem is also addressed by our scenario. Allowing the density perturbations produced by the second episode of inflation to be large also lessens the fine-tuning required in the scalar potential and makes reheating much easier. We briefly speculate on the possibility that the second episode of inflation proceeds through the nucleation of bubbles, which today manifest themselves as empty bubbles whose surfaces are covered with galaxies. 37 refs., 1 fig

  1. Double Outlet Right Ventricle

    Science.gov (United States)

    ... Right Ventricle Menu Topics Topics FAQs Double Outlet Right Ventricle Double outlet right ventricle (DORV) is a rare form of congenital heart disease. En español Double outlet right ventricle (DORV) is a rare form of congenital ...

  2. Double contrast arthrography of the shoulder

    International Nuclear Information System (INIS)

    Gasparini, D.

    1991-01-01

    From 1980 to 1989 the author performed 481 double-contrast arthrographic examinations of the shoulder (DCSA). A hundred and forty-two complete and 46 partial rotator cuff tears were demonstrated; 68 of them underwent surgical exploration. Results confirmed DCSA capabilities in detecting both their location (100%) and size (95%). Moreover, thickness (89%) and erosions (94%) in tendon edges and surfaces were demonstrated - that is, all the qualitative information needed to depict degenerative processes. Such evidence may also affect treatment planning

  3. Edge-injective and edge-surjective vertex labellings

    DEFF Research Database (Denmark)

    Brandt, Stephan; Rautenbach, D.; Regen, F.

    2010-01-01

    For a graph G = (V, E) we consider vertex-k-labellings f : V → {1,2, ,k} for which the induced edge weighting w : E → {2, 3,., 2k} with w(uv) = f(u) + f(v) is injective or surjective or both. We study the relation between these labellings and the number theoretic notions of an additive basis and ...

  4. Generalized Multi-Edge Analysis for K-Edge Densitometry

    International Nuclear Information System (INIS)

    Collins, M.

    1998-01-01

    In K-edge densitometry (KED), a continuous-energy x-ray beam is transmitted through a liquid sample. The actinide content of the sample can be measured through analysis of the transmitted portion of the x-ray beam. Traditional methods for KED analysis allow the simultaneous calculation of, at most, two actinide concentrations. A generalized multi-edge KED analytical method is presented, allowing up to six actinide concentrations to be calculated simultaneously. Applications of this method for hybrid KED/x-ray fluorescence (HKED) systems are discussed. Current HKED systems require the operator to know the approximate actinide content of each sample, and manually select the proper analysis mode. The new multi-edge KED technique allows rapid identification of the major actinide components in a sample, independent of actinide content. The proper HKED analysis mode can be selected automatically, without requiring sample content information from the user. Automatic HKED analysis would be especially useful in an analytical laboratory setting, where samples with truly unknown characteristics are encountered. Because this technique requires no hardware modifications, several facilities that use HKED may eventually benefit from this approach

  5. Strong genetic differentiation among east Atlantic populations of the sword razor shell ( Ensis siliqua) assessed with mtDNA and RAPD markers

    Science.gov (United States)

    Arias, Alberto; Fernández-Moreno, Mercedes; Fernández-Tajes, Juan; Gaspar, Miguel B.; Méndez, Josefina

    2011-03-01

    The sword razor shell Ensis siliqua (Linnaeus, 1758) is a bivalve with a high commercial value being appreciated in fresh and processed markets. However, the genetic studies carried out in populations of E. siliqua are scarce. In this work, the genetic variability and differentiation of the sword razor shell was assessed using PCR-RFLPs of a fragment of the 16S rRNA mitochondrial gene and random amplified polymorphic loci (RAPD) in nine localities from Ireland, Spain, and Portugal. In the 314 individuals examined for the mitochondrial fragment, 12 composite haplotypes were observed; meanwhile, a unique phenotype was observed for each of the 242 individuals analyzed with 61 RAPD loci. Two of the mitochondrial composite haplotypes accounted for the majority of individuals (89.81%) and showed a remarkably disjoint distribution between Irish and Iberian samples, with the exception of Aveiro which exhibited as the most frequent haplotype the same found in Ireland. The level of variability observed for each sample was generally correlated with both types of markers and the results obtained suggest the existence of a strong population differentiation between Irish and Iberian localities, except for the Portuguese sample from Aveiro which is surprisingly closer to Irish individuals, although it is probably highly differentiated.

  6. Double hard scattering without double counting

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Gaunt, Jonathan R. [VU Univ. Amsterdam (Netherlands). NIKHEF Theory Group; Schoenwald, Kay [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2017-02-15

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  7. Double hard scattering without double counting

    International Nuclear Information System (INIS)

    Diehl, Markus; Gaunt, Jonathan R.

    2017-02-01

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  8. The Significance of the PD-L1 Expression in Non-Small-Cell Lung Cancer: Trenchant Double Swords as Predictive and Prognostic Markers.

    Science.gov (United States)

    Takada, Kazuki; Toyokawa, Gouji; Shoji, Fumihiro; Okamoto, Tatsuro; Maehara, Yoshihiko

    2018-03-01

    Lung cancer is the leading cause of death due to cancer worldwide. Surgery, chemotherapy, and radiotherapy have been the standard treatment for lung cancer, and targeted molecular therapy has greatly improved the clinical course of patients with non-small-cell lung cancer (NSCLC) harboring driver mutations, such as in epidermal growth factor receptor and anaplastic lymphoma kinase genes. Despite advances in such therapies, the prognosis of patients with NSCLC without driver oncogene mutations remains poor. Immunotherapy targeting programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) has recently been shown to improve the survival in advanced NSCLC. The PD-L1 expression on the surface of tumor cells has emerged as a potential biomarker for predicting responses to immunotherapy and prognosis after surgery in NSCLC. However, the utility of PD-L1 expression as a predictive and prognostic biomarker remains controversial because of the existence of various PD-L1 antibodies, scoring systems, and positivity cutoffs. In this review, we summarize the data from representative clinical trials of PD-1/PD-L1 immune checkpoint inhibitors in NSCLC and previous reports on the association between PD-L1 expression and clinical outcomes in patients with NSCLC. Furthermore, we discuss the future perspectives of immunotherapy and immune checkpoint factors. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Edge imaging in intense beams

    Directory of Open Access Journals (Sweden)

    S. Bernal

    2002-06-01

    Full Text Available The appearance of rings of charge observed near the edge of beams from high-perveance guns is described with a simple ray tracing technique inspired by the particle-core model. We illustrate the technique, which has no analog in light optics, with examples from experiments employing solenoid focusing of an electron beam. The rings of charge result from the combined effects of external focusing and space-charge forces acting on paraxial fringe particles with relatively large initial transverse velocities. The model is independent of the physical mechanisms responsible for the fringe particles. Furthermore, the focal length for edge imaging in a uniform focusing channel is derived using a linearized trajectory equation for the motion of fringe particles. Counterintuitively, the focal length decreases as the beam current increases.

  10. Edge localized mode physics and operational aspects in tokamaks

    International Nuclear Information System (INIS)

    Becoulet, M; Huysmans, G; Sarazin, Y; Garbet, X; Ghendrih, Ph; Rimini, F; Joffrin, E; Litaudon, X; Monier-Garbet, P; Ane, J-M; Thomas, P; Grosman, A; Parail, V; Wilson, H; Lomas, P; Vries, P de; Zastrow, K-D; Matthews, G F; Lonnroth, J; Gerasimov, S; Sharapov, S; Gryaznevich, M; Counsell, G; Kirk, A; Valovic, M; Buttery, R; Loarte, A; Saibene, G; Sartori, R; Leonard, A; Snyder, P; Lao, L L; Gohil, P; Evans, T E; Moyer, R A; Kamada, Y; Chankin, A; Oyama, N; Hatae, T; Asakura, N; Tudisco, O; Giovannozzi, E; Crisanti, F; Perez, C P; Koslowski, H R; Eich, T; Sips, A; Horton, L; Hermann, A; Lang, P; Stober, J; Suttrop, W; Beyer, P; Saarelma, S

    2003-01-01

    Recent progress in experimental and theoretical studies of edge localized mode (ELM) physics is reviewed for the reactor relevant plasma regimes, namely the high confinement regimes, that is, H-modes and advanced scenarios. Theoretical approaches to ELM physics, from a linear ideal magnetohydrodynamic (MHD) stability analysis to non-linear transport models with ELMs are discussed with respect to experimental observations, in particular the fast collapse of pedestal pressure profiles, magnetic measurements and scrape-off layer transport during ELMs. High confinement regimes with different types of ELMs are addressed in this paper in the context of development of operational scenarios for ITER. The key parameters that have been identified at present to reduce the energy losses in Type I ELMs are operation at high density, high edge magnetic shear and high triangularity. However, according to the present experimental scaling for the energy losses in Type I ELMs, the extrapolation of such regimes for ITER leads to unacceptably large heat loads on the divertor target plates exceeding the material limits. High confinement H-mode scenarios at high triangularity and high density with small ELMs (Type II), mixed regimes (Type II and Type I) and combined advanced regimes at high beta p are discussed for present-day tokamaks. The optimum combination of high confinement and small MHD activity at the edge in Type II ELM scenarios is of interest to ITER. However, to date, these regimes have been achieved in a rather narrow operational window and far from ITER parameters in terms of collisionality, edge safety factor and beta p . The compatibility of the alternative internal transport barrier (ITB) scenario with edge pedestal formation and ELMs is also addressed. Edge physics issues related to the possible combination of small benign ELMs (Type III, Type II ELMs, quiescent double barrier) and high performance ITBs are discussed for present-day experiments (JET, JT-60U, DIII-D) in

  11. Edge localized mode physics and operational aspects in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Becoulet, M [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Huysmans, G [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Sarazin, Y [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Garbet, X [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Ghendrih, Ph [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Rimini, F [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Joffrin, E [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Litaudon, X [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Monier-Garbet, P [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Ane, J-M [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Thomas, P [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Grosman, A [Association Euratom-CEA, CEA Cadarache, F-13108 St Paul-lez-Durance (France); Parail, V [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Wilson, H [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Lomas, P [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Vries, P de[Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Zastrow, K-D [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Matthews, G F [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Lonnroth, J [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom); Gerasimov, S [Euratom/UKAEA Association, Fusion Culham Science Centre, Abingdon, OX14 3EA (United Kingdom)] [and others

    2003-12-01

    Recent progress in experimental and theoretical studies of edge localized mode (ELM) physics is reviewed for the reactor relevant plasma regimes, namely the high confinement regimes, that is, H-modes and advanced scenarios. Theoretical approaches to ELM physics, from a linear ideal magnetohydrodynamic (MHD) stability analysis to non-linear transport models with ELMs are discussed with respect to experimental observations, in particular the fast collapse of pedestal pressure profiles, magnetic measurements and scrape-off layer transport during ELMs. High confinement regimes with different types of ELMs are addressed in this paper in the context of development of operational scenarios for ITER. The key parameters that have been identified at present to reduce the energy losses in Type I ELMs are operation at high density, high edge magnetic shear and high triangularity. However, according to the present experimental scaling for the energy losses in Type I ELMs, the extrapolation of such regimes for ITER leads to unacceptably large heat loads on the divertor target plates exceeding the material limits. High confinement H-mode scenarios at high triangularity and high density with small ELMs (Type II), mixed regimes (Type II and Type I) and combined advanced regimes at high beta{sub p} are discussed for present-day tokamaks. The optimum combination of high confinement and small MHD activity at the edge in Type II ELM scenarios is of interest to ITER. However, to date, these regimes have been achieved in a rather narrow operational window and far from ITER parameters in terms of collisionality, edge safety factor and beta{sub p}. The compatibility of the alternative internal transport barrier (ITB) scenario with edge pedestal formation and ELMs is also addressed. Edge physics issues related to the possible combination of small benign ELMs (Type III, Type II ELMs, quiescent double barrier) and high performance ITBs are discussed for present-day experiments (JET, JT-60U

  12. Nonreference Medical Image Edge Map Measure

    Directory of Open Access Journals (Sweden)

    Karen Panetta

    2014-01-01

    Full Text Available Edge detection is a key step in medical image processing. It is widely used to extract features, perform segmentation, and further assist in diagnosis. A poor quality edge map can result in false alarms and misses in cancer detection algorithms. Therefore, it is necessary to have a reliable edge measure to assist in selecting the optimal edge map. Existing reference based edge measures require a ground truth edge map to evaluate the similarity between the generated edge map and the ground truth. However, the ground truth images are not available for medical images. Therefore, a nonreference edge measure is ideal for medical image processing applications. In this paper, a nonreference reconstruction based edge map evaluation (NREM is proposed. The theoretical basis is that a good edge map keeps the structure and details of the original image thus would yield a good reconstructed image. The NREM is based on comparing the similarity between the reconstructed image with the original image using this concept. The edge measure is used for selecting the optimal edge detection algorithm and optimal parameters for the algorithm. Experimental results show that the quantitative evaluations given by the edge measure have good correlations with human visual analysis.

  13. Gyrosheath near the tokamak edge

    International Nuclear Information System (INIS)

    Hazeltine, R.D.; Xiao, H.; Valanju, P.M.

    1993-03-01

    A new model for the structure of the radial electric field profile in the edge during the H-mode is proposed. Charge separation caused by the difference between electron and ion gyromotion, or more importantly in a tokamak, the banana motion (halo effect) can self-consistently produce an electric dipole moment that causes the sheared radial electric field. The calculated results based on the model are consistent with D-III D and TEXTOR experimental results

  14. Effects of edge reconstruction on the common groups terminated zigzag phosphorene nanoribbon

    International Nuclear Information System (INIS)

    Xiao, Huaping; Guo, Sumei; Zhang, Chunxiao; He, Chaoyu; Zhong, Jianxin

    2017-01-01

    Edge configuration plays an important role in the electronic properties of nano-structures. In this work, we perform first-principles calculations to study the effects of the cooperation between neighbor groups on the edge configuration and the electronic properties of zigzag-PNRs (ZPNRs) terminated by common groups H, F, O, S and OH. We find that the cooperation has little effect on the H(F)-terminated ZPNRs, but gives rise to an edge reconstruction for the O(S)-terminated ZPNRs. The edge reconstruction derives from the repulsion between neighbor O atoms and the distortion of the P skeleton induced by the p state coupling among the edge, second edge and third edge P atoms. In comparison to the H-terminated ZPNRs, O-terminated ZPNRs are also a semiconductor and enlarge the band gap, but bring about an extra transport channel for the charge transport at the edge and decreases the effective mass of the electron and hole. OH-terminated ZPNRs also undergo a doubling of the unit cell (UC) along the periodic direction because of the different directions of the neighbor O–H bonds. In comparison with the H-terminated ZPNRs, OH-terminated ZPNRs show a similar band gap and electronic effective mass, but increase the effective mass of the hole. (paper)

  15. Optimization of edge state velocity in the integer quantum Hall regime

    Science.gov (United States)

    Sahasrabudhe, H.; Novakovic, B.; Nakamura, J.; Fallahi, S.; Povolotskyi, M.; Klimeck, G.; Rahman, R.; Manfra, M. J.

    2018-02-01

    Observation of interference in the quantum Hall regime may be hampered by a small edge state velocity due to finite phase coherence time. Therefore designing two quantum point contact (QPCs) interferometers having a high edge state velocity is desirable. Here we present a new simulation method for designing heterostructures with high edge state velocity by realistically modeling edge states near QPCs in the integer quantum Hall effect (IQHE) regime. Using this simulation method, we also predict the filling factor at the center of QPCs and their conductance at different gate voltages. The 3D Schrödinger equation is split into 1D and 2D parts. Quasi-1D Schrödinger and Poisson equations are solved self-consistently in the IQHE regime to obtain the potential profile, and quantum transport is used to solve for the edge state wave functions. The velocity of edge states is found to be /B , where is the expectation value of the electric field for the edge state. Anisotropically etched trench gated heterostructures with double-sided delta doping have the highest edge state velocity among the structures considered.

  16. Knife-edge seal for vacuum bagging

    Science.gov (United States)

    Rauschl, J. A.

    1980-01-01

    Cam actuated clamps pinch bagging material between long knife edge (mounted to clamps) and high temperature rubber cushion bonded to baseplate. No adhesive, tape, or sealing groove is needed to seal edge of bagging sheet against base plate.

  17. Environmental Dataset Gateway (EDG) REST Interface

    Data.gov (United States)

    U.S. Environmental Protection Agency — Use the Environmental Dataset Gateway (EDG) to find and access EPA's environmental resources. Many options are available for easily reusing EDG content in other...

  18. Organizing on the Edge: Appreciation and Critique

    National Research Council Canada - National Science Library

    Scott, W. R

    2006-01-01

    .... Hayes, "Power to the Edge: Command, Control in the Information Age" (2003). The author places the "edge" perspective in the broader context of organizational studies, noting both its strengths and limitations...

  19. Edge effect on weevils and spiders

    Directory of Open Access Journals (Sweden)

    R. Horváth

    2002-05-01

    Full Text Available The edge effect on weevils and spiders was tested along oak forest – meadow transects using sweep-net samples at the Síkfökút Project in Hungary. For spiders the species richness was significantly higher in the forest edge than either in the meadow or the forest interior. For weevils the species richness of the forest edge was higher than that of the meadow, but the difference was not statistically significant whereas the species richness of the forest interior was significantly lower than that of the forest edge and the meadow. The composition of the spider assemblage of the edge was more similar to the forest, while the composition of weevils in the edge was more similar to the meadow. Our results based on two invertebrate groups operating on different trophic levels suggest that there is a significant edge effect for the studied taxa resulting in higher species richness in the edge.

  20. Recent experimental studies of edge and internal transport barriers in the DIII-D tokamak

    International Nuclear Information System (INIS)

    Gohil, P; Baylor, L R; Burrell, K H; Casper, T A; Doyle, E J; Greenfield, C M; Jernigan, T C; Kinsey, J E; Lasnier, C J; Moyer, R A; Murakami, M; Rhodes, T L; Rudakov, D L; Staebler, G M; Wang, G; Watkins, J G; West, W P; Zeng, L

    2003-01-01

    Results from recent experiments on the DIII-D tokamak have revealed many important details on transport barriers at the plasma edge and in the plasma core. These experiments include: (a) the formation of the H-mode edge barrier directly by pellet injection; (b) the formation of a quiescent H-mode edge barrier (QH-mode) which is free from edge localized modes, but which still exhibits good density and radiative power control; (c) the formation of multiple transport barriers, such as the quiescent double barrier (QDB) which combines an internal transport barrier with the quiescent H-mode edge barrier. Results from the pellet-induced H-mode experiments indicate that: (a) the edge temperature (electron or ion) does not need to attain a critical value for the formation of the H-mode barrier, (b) pellet injection leads to an increased gradient in the radial electric field, E r , at the plasma edge; (c) the experimentally determined edge parameters at barrier transition are well below the predictions of several theories on the formation of the H-mode barrier, (d) pellet injection can lower the threshold power required to form the H-mode barrier. The quiescent H-mode barrier exhibits good density control as the result of continuous magnetohydrodynamic activity at the plasma edge called the edge harmonic oscillation (EHO). The EHO enhances the edge particle transport whilst maintaining a good energy transport barrier. The ability to produce multiple barriers in the QDB regime has led to long duration, high-performance plasmas with β N H 89 values of 7 for up to 10 times the confinement time. Density profile control in the plasma core of QDB plasmas has been demonstrated using on-axis electron cyclotron heating

  1. Explanation of L→H mode transition based on gradient stabilization of edge thermal fluctuations

    International Nuclear Information System (INIS)

    Stacey, W.M.

    1996-01-01

    A linear analysis of thermal fluctuations, using a fluid model which treats the large radial gradient related phenomena in the plasma edge, leads to a constraint on the temperature and density gradients for stabilization of edge temperature fluctuations. A temperature gradient, or conductive edge heat flux, threshold is identified. It is proposed that the L→H transition takes place when the conductive heat flux to the edge produces a sufficiently large edge temperature gradient to stabilize the edge thermal fluctuations. The consequences following from this mechanism for the L→H transition are in accord with observed phenomena associated with the L→H transition and with the observed parameter dependences of the power threshold. First, a constraint is established on the edge temperature and density gradients that are sufficient for the stability of edge temperature fluctuations. A slab approximation for the thin plasma edge and a fluid model connected to account for the large radial gradients present in the plasma edge are used. Equilibrium solutions are characterized by the value of the density and of its gradient L n -1 double-bond - n -1 , etc. Temperature fluctuations expanded about the equilibrium value are then used in the energy balance equation summed over plasma ions, electrons and impurities to obtain, after linearization, an expression for the growth rate ω of edge localized thermal fluctuations. Thermal stability of the equilibrium solution requires ω ≤ 0, which establishes a constraint that must be satisfied by L n -1 and L T -1 . The limiting value of the constraint (ω = 0) leads to an expression for the minimum value of that is sufficient for thermal stability, for a given value of L T -1. It is found that there is a minimum value of the temperature gradient, (L T -1 ) min that is necessary for a stable solution to exist for any value of L n -1

  2. Modification of the NACA 632-415 leading edge for better aerodynamic performance

    DEFF Research Database (Denmark)

    Bak, C.; Fuglsang, P.

    2002-01-01

    Double stall causes more than one power level when stall-regulated wind turbines operate in stall. This involves significant uncertainty on power production and loads. To avoid double stall, a new leading edge was designed for the NACA 632-415 airfoil, an airfoil that is often used in the tip...... region of wind turbines. A numerical optimization tool incorporating XFOIL was used with a special formulation for the airfoil leading edge shape. The EllipSys2D CFD code was used to analyze the modified airfoil. In theory and in wind tunnel tests, the modified airfoil showed smooth and stable stall...... stall and aerodynamic damping characteristics for the modified airfoil and the NACA 632-415 airfoil were the same. The modified airfoil with leading edge roughness in general had better characteristics compared with the NACA 632-415 airfoil. ©2002 ASME...

  3. Co-Ethnic Network, Social Class, and Heritage Language Maintenance among Chinese Immigrant Families

    Science.gov (United States)

    Zhang, Donghui

    2012-01-01

    This ethnographic study investigated heritage language maintenance among two distinct groups of Chinese immigrant families (Mandarin and Fujianese) from the social network perspective. The results indicated that a co-ethnic network could be a double-edged sword, which works differently on children from different social classes. While the Mandarin…

  4. Rethinking Diversity.

    Science.gov (United States)

    1996

    These three papers were presented at a symposium on rethinking diversity in human resource development (HRD) moderated by Neal Chalofsky at the 1996 conference of the Academy of Human Resource Development. "Diversity: A Double-Edged Sword" (Sally F. Angus) presents the notion of work force diversity through two differing perspectives in order to…

  5. a study of gold mining industry in ghana

    African Journals Online (AJOL)

    PUBLICATIONS1

    is the case of Ghana. The abstract of the ... and tax waivers for foreign mining companies amount to millions ... it provides a rich re- view of literature where the legal ramifications ..... ciplinary research: gold mining is a double edged sword, and ...

  6. Introduction to the Study of Islamic Arms and Armours

    Directory of Open Access Journals (Sweden)

    Rahman Zaky, A.

    1961-12-01

    Full Text Available Early Islamic weapons of any archaeological value are comparatively very few. The earlier swords are all straight, mostly double edged. Curved sabres do not become common until circa 1500, nevertheless the Mongol type started to become a fashion in some Moslem provinces during the 13th cent. Here, we mention some known types.

    No disponible.

  7. Bleeding risk in 'real world' patients with atrial fibrillation: comparison of two established bleeding prediction schemes in a nationwide cohort

    DEFF Research Database (Denmark)

    Olesen, J B; Lip, G Y H; Hansen, P R

    2011-01-01

    Oral anticoagulation (OAC) in patients with atrial fibrillation (AF) is a double-edged sword, because it decreases the risk of stroke at the cost of an increased risk of bleeding. We compared the performance of a new bleeding prediction scheme, HAS-BLED, with an older bleeding prediction scheme...

  8. Human Flesh Search Engine and Online Privacy.

    Science.gov (United States)

    Zhang, Yang; Gao, Hong

    2016-04-01

    Human flesh search engine can be a double-edged sword, bringing convenience on the one hand and leading to infringement of personal privacy on the other hand. This paper discusses the ethical problems brought about by the human flesh search engine, as well as possible solutions.

  9. Language Can: Ensuring National Security through Effective Use of ...

    African Journals Online (AJOL)

    This paper is one of such efforts to show that ineffective language use can threaten national security while effective use can enhance it. Language use in interpersonal relationship is like a double- edged sword. It can be used to destroy as well as be used to mend. The present democratic dispensation in Nigeria has been ...

  10. Dental fluorosis and dental caries prevalence among 12 and 15 ...

    African Journals Online (AJOL)

    Background: Fluoride is a double edged sword. The assessment of dental caries and fluorosis in endemic fluoride areas will facilitate in assessing the relation between fluoride concentrations in water with dental caries, dental fluorosis simultaneously. Aim: The objective of the following study is to assess the dental caries ...

  11. Are Plush Dorms and Fancy Food Plans Important Drivers of College Cost?

    Science.gov (United States)

    Archibald, Robert B.; Feldman, David H.

    2011-01-01

    Like most schools, College of William and Mary is not shy about touting its amenities. The Webpage that advertises the college's housing and dining options begins with, "Wireless and Starbucks? Thomas Jefferson never had it this good." Advertising of this sort is a double-edged public-relations sword. Colleges and universities clearly want to…

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Hsinyu Lee. Articles written in Journal of Biosciences. Volume 37 Issue 1 March 2012 pp 157-165 Review. Autophagy: A double-edged sword in Alzheimer's disease · Ying-Tsen Tung Bo-Jeng Wang Ming-Kuan Hu Wen-Ming Hsu Hsinyu Lee Wei-Pang Huang Yung-Feng Liao.

  13. Impact of Globalization on the Right to Health as an Instance of Human Rights

    Directory of Open Access Journals (Sweden)

    Jayashree Palande

    2011-07-01

    Full Text Available Since the advent of globalization, the issue of human rights - especially right to health- and their violation through the process of globalization was discussed. These impotent rights are affected both in positive and negative way by the globalization. Present study scrutinizes these effects and concludes that globalization is functioning as a double edged-sword in this regards.

  14. Diversity cognition and climates

    NARCIS (Netherlands)

    van Knippenberg, D.; Homan, A.C.; van Ginkel, W.; Roberson, Q.M.

    2013-01-01

    Demographic diversity at work can yield performance benefits but also invite psychological disengagement and be a source of interpersonal tension. In managing this double-edged sword of demographic diversity, the role of diversity cognition (beliefs, attitudes) and climates seems particularly

  15. Development of a generic Smart City model using MARVEL (abstract only)

    NARCIS (Netherlands)

    Veldhuis, G.A.; Scheepstal, P.G.M. van; Vink, N.

    2014-01-01

    The concept of the ‘Smart City’ is seen as double edged sword that should alleviate societal and environmental problems as well as fuel economic growth. Literature has identified many important characteristics of Smart Cities but has not yet provided a systemic approach that describes the

  16. CFAR Edge Detector for Polarimetric SAR Images

    DEFF Research Database (Denmark)

    Schou, Jesper; Skriver, Henning; Nielsen, Allan Aasbjerg

    2003-01-01

    Finding the edges between different regions in an image is one of the fundamental steps of image analysis, and several edge detectors suitable for the special statistics of synthetic aperture radar (SAR) intensity images have previously been developed. In this paper, a new edge detector for polar...

  17. Energetics of highly kinked step edges

    NARCIS (Netherlands)

    Zandvliet, Henricus J.W.

    2010-01-01

    We have determined the step edge free energy, the step edge stiffness and dimensionless inverse step edge stiffness of the highly kinked < 010> oriented step on a (001) surface of a simple square lattice within the framework of a solid-on-solid model. We have found an exact expression for the step

  18. Acyclicity in edge-colored graphs

    DEFF Research Database (Denmark)

    Gutin, Gregory; Jones, Mark; Sheng, Bin

    2017-01-01

    A walk W in edge-colored graphs is called properly colored (PC) if every pair of consecutive edges in W is of different color. We introduce and study five types of PC acyclicity in edge-colored graphs such that graphs of PC acyclicity of type i is a proper superset of graphs of acyclicity of type...

  19. Edge and coupled core/edge transport modelling in tokamaks

    International Nuclear Information System (INIS)

    Lodestro, L.L.; Casper, T.A.; Cohen, R.H.

    1999-01-01

    Recent advances in the theory and modelling of tokamak edge, scrape-off-layer (SOL) and divertor plasmas are described. The effects of the poloidal E x B drift on inner/outer divertor-plate asymmetries within a 1D analysis are shown to be in good agreement with experimental trends; above a critical v ExB , the model predicts transitions to supersonic flow at the inboard midplane. 2D simulations show the importance of E x B flow in the private-flux region and of ∇ B-drifts. A theory of rough plasma-facing surfaces is given, predicting modifications to the SOL plasma. The parametric dependence of detached-plasma states in slab geometry has been explored; with sufficient pumping, the location of the ionization front can be controlled; otherwise only fronts near the plate or the X-point are stable. Studies with a more accurate Monte-Carlo neutrals model and a detailed non-LTE radiation-transport code indicate various effects are important for quantitative modelling. Detailed simulations of the DIII-D core and edge are presented; impurity and plasma flow are discussed and shown to be well modelled with UEDGE. (author)

  20. Edge and coupled core-edge transport modelling in tokamaks

    International Nuclear Information System (INIS)

    Lodestro, L.L.; Casper, T.A.; Cohen, R.H.

    2001-01-01

    Recent advances in the theory and modelling of tokamak edge, scrape-off-layer (SOL) and divertor plasmas are described. The effects of the poloidal ExB drift on inner/outer divertor-plate asymmetries within a 1D analysis are shown to be in good agreement with experimental trends; above a critical v ExB, the model predicts transitions to supersonic SOL flow at the inboard midplane. 2D simulations show the importance of ExB flow in the private-flux region and of ∇ B-drifts. A theory of rough plasma-facing surfaces is given, predicting modifications to the SOL plasma. The parametric dependence of detached-plasma states in slab geometry has been explored; with sufficient pumping, the location of the ionization front can be controlled; otherwise only fronts near the plate or the X-point are stable. Studies with a more accurate Monte-Carlo neutrals model and a detailed non-LTE radiation-transport code indicate various effects are important for quantitative modelling. Detailed simulations of the DIII-D core and edge are presented; impurity and plasma flow are discussed and shown to be well modelled with UEDGE. (author)

  1. Image Edge Tracking via Ant Colony Optimization

    Science.gov (United States)

    Li, Ruowei; Wu, Hongkun; Liu, Shilong; Rahman, M. A.; Liu, Sanchi; Kwok, Ngai Ming

    2018-04-01

    A good edge plot should use continuous thin lines to describe the complete contour of the captured object. However, the detection of weak edges is a challenging task because of the associated low pixel intensities. Ant Colony Optimization (ACO) has been employed by many researchers to address this problem. The algorithm is a meta-heuristic method developed by mimicking the natural behaviour of ants. It uses iterative searches to find the optimal solution that cannot be found via traditional optimization approaches. In this work, ACO is employed to track and repair broken edges obtained via conventional Sobel edge detector to produced a result with more connected edges.

  2. K-edge densitometer (KED)

    Energy Technology Data Exchange (ETDEWEB)

    Sprinkle, J.K.; Hansen, W.J.

    1993-02-11

    In 1979, a K-edge densitometer (KED) was installed by the Safeguards Assay group from Los Alamos National Laboratory in the PNC reprocessing plant at Tokai-mura, Japan. It uses an active nondestructive assay technique, KED, to measure the plutonium concentration of the product solution. The measurement uncertainty of an assay depends on the count time chosen, but can be 0.5% or better. The computer hardware and software were upgraded in 1992. This manual describes the operation of the instrument, with an emphasis on the user interface to the software.

  3. Instant Adobe Edge Inspect starter

    CERN Document Server

    Khan, Joseph

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This easy-to-understand Starter guide will get you up to speed with Adobe Edge Inspect quickly and with little effort.This book is for frontend web developers and designers who are developing and testing web applications targeted for mobile browsers. It's assumed that you have a basic understanding of creating web applications using HTML, CSS, and JavaScript, as well as being familiar with running web pages from local HTTP servers. Readers are a

  4. How Forest Inhomogeneities Affect the Edge Flow

    DEFF Research Database (Denmark)

    Boudreault, Louis-Étienne; Dupont, Sylvain; Bechmann, Andreas

    2016-01-01

    Most of our knowledge on forest-edge flows comes from numerical and wind-tunnel experiments where canopies are horizontally homogeneous. To investigate the impact of tree-scale heterogeneities (>1 m) on the edge-flow dynamics, the flow in an inhomogeneous forest edge on Falster island in Denmark...... is investigated using large-eddy simulation. The three-dimensional forest structure is prescribed in the model using high resolution helicopter-based lidar scans. After evaluating the simulation against wind measurements upwind and downwind of the forest leading edge, the flow dynamics are compared between...... the scanned forest and an equivalent homogeneous forest. The simulations reveal that forest inhomogeneities facilitate flow penetration into the canopy from the edge, inducing important dispersive fluxes in the edge region as a consequence of the flow spatial variability. Further downstream from the edge...

  5. Energetics of edge oxidization of graphene nanoribbons

    Science.gov (United States)

    Yasuma, Airi; Yamanaka, Ayaka; Okada, Susumu

    2018-06-01

    On the basis of the density functional theory, we studied the geometries and energetics of O atoms adsorbed on graphene edges for simulating the initial stage of the edge oxidization of graphene. Our calculations showed that oxygen atoms are preferentially adsorbed onto the graphene edges with the zigzag portion, resulting in a large adsorption energy of about 5 eV. On the other hand, the edges with armchair shape are rarely oxidized, or the oxidization causes substantial structural reconstructions, because of the stable covalent bond at the armchair edge with the triple bond nature. Furthermore, the energetics sensitively depends on the edge angles owing to the inhomogeneity of the charge density at the edge atomic sites.

  6. Haptic Edge Detection Through Shear

    Science.gov (United States)

    Platkiewicz, Jonathan; Lipson, Hod; Hayward, Vincent

    2016-03-01

    Most tactile sensors are based on the assumption that touch depends on measuring pressure. However, the pressure distribution at the surface of a tactile sensor cannot be acquired directly and must be inferred from the deformation field induced by the touched object in the sensor medium. Currently, there is no consensus as to which components of strain are most informative for tactile sensing. Here, we propose that shape-related tactile information is more suitably recovered from shear strain than normal strain. Based on a contact mechanics analysis, we demonstrate that the elastic behavior of a haptic probe provides a robust edge detection mechanism when shear strain is sensed. We used a jamming-based robot gripper as a tactile sensor to empirically validate that shear strain processing gives accurate edge information that is invariant to changes in pressure, as predicted by the contact mechanics study. This result has implications for the design of effective tactile sensors as well as for the understanding of the early somatosensory processing in mammals.

  7. Double layers in a modestly collisional electronegative discharge

    CERN Document Server

    Sheridan, T E

    1999-01-01

    The effect of ion-neutral collisions on the structure and ion flux emanating from a steady-state, planar discharge with two negative components is investigated. The positive ion component is modelled as a cold fluid subject to constant-mobility collisions, while the electrons and negative ions obey Boltzmann relations. The model includes the collisionless limit. When the negative ions are sufficiently cold three types of discharge structures are found. For small negative ion concentrations or high collisionality, the discharge is 'stratified', with an electronegative core and an electropositive edge. For the opposite conditions, the discharge is 'uniform' with the negative ion density remaining significant at the edge of the plasma. Between these cases lies the special case of a double-layer-stratified discharge, where quasi-neutrality is violated at the edge of the electronegative core. Double-layer-stratified solutions are robust in that they persist for moderate collisionality. Numerical solutions for fini...

  8. Predicted solar cell edge radiation effects

    International Nuclear Information System (INIS)

    Gates, M.T.

    1993-01-01

    The Advanced Solar Cell Orbital Test (ASCOT) will test six types of solar cells in a high energy proton environment. During the design of the experiment a question was raised about the effects of proton radiation incident on the edge of the solar cells and whether edge radiation shielding was required. Historical geosynchronous data indicated that edge radiation damage is not detectable over the normal end of life solar cell degradation; however because the ASCOT radiation environment has a much higher and more energetic fluence of protons, considerably more edge damage is expected. A computer analysis of the problem was made by modeling the expected radiation damage at the cell edge and using a network model of small interconnected solar cells to predict degradation in the cell's electrical output. The model indicated that the deepest penetration of edge radiation was at the top of the cell near the junction where the protons have access to the cell through the low density cell/cover adhesive layer. The network model indicated that the cells could tolerate high fluences at their edge as long as there was high electrical resistance between the edge radiated region and the contact system on top of the cell. The predicted edge radiation related loss was less than 2% of maximum power for GaAs/Ge solar cells. As a result, no edge radiation protection was used for ASCOT

  9. [O{sub 2}Pb{sub 3}]{sub 2}(BO{sub 3})Br. An oxidoborate oxide bromide with the {sub ∞}{sup 1}[O{sub 2}Pb{sub 3}] double chains based on edge-sharing OPb{sub 4} tetrahedra

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Lingyun [College of Chemistry and Environmental Science, Hebei University, Baoding (China); Biology and Chemistry Department, Baoding University (China); Yang, Jiao; Shen, Shigang; Liu, Zhenzhen; Sun, Sufang [College of Chemistry and Environmental Science, Hebei University, Baoding (China); Chen, Xiaojing [Biology and Chemistry Department, Baoding University (China)

    2017-04-04

    Through extensive research on the PbO / PbBr{sub 2} / B{sub 2}O{sub 3} system, a new single crystal of yellow lead-containing oxyborate bromine, [O{sub 2}Pb{sub 3}]{sub 2}(BO{sub 3})Br, was grown from the melt. It crystallizes in the centrosymmetric space group Cmcm (no. 63) of the orthorhombic system with the following unit cell dimensions: a = 9.5748(8) Aa, b = 20.841(2) Aa, c = 5.7696(5) Aa, and Z = 4. The whole structure is characterized by an infinite one-dimensional (1D) {sub ∞}{sup 1}[O{sub 2}Pb{sub 3}] double chain, which is based on the OPb{sub 4} oxocentered tetrahedra and considered as the derivative of the continuous sheet of OPb{sub 4} tetrahedra from the tetragonal modification of α-PbO. The 1D {sub ∞}{sup 1}[O{sub 2}Pb{sub 3}] double chains are further bridged by the BO{sub 3} units through common oxygen atoms to form two-dimensional (2D) {sub ∞}{sup 1}[(O{sub 2}Pb{sub 3})(BO{sub 3})] layers, with Br atoms situated between the layers. IR spectroscopy, UV/Vis/NIR diffuse reflectance spectroscopy, and thermal analysis were also performed on the reported material. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. International double taxation

    OpenAIRE

    Körbl, Hugo

    2012-01-01

    1 Summary This thesis deals with the issue of international double taxation of income and capital and methods for its solution. International double taxation is an issue which states began to deal with in the late 19th century. This interest intensified after the First World War when also the League of Nations (predecessor of the United Nations) began to deal with international double taxation. Most attention the phenomenon of double taxation of income and capital with an international elemen...

  11. Ethical decisions at the edge.

    Science.gov (United States)

    Gillett, Grant

    2008-05-01

    Medicine grows incrementally in its ability to treat patients and at the growing edge it poses problems about the appropriateness of treatments that are different from those where good practice conforms to widely agreed standards. The growth of access to medical knowledge and the diversity of contemporary theoretical and clinical medicine have spawned deep divisions in the profession and divergent opinions about what constitutes reasonable care. That hallmark of acceptable practice is also under pressures from the threat of litigation, a highly commercialised contemporary medical environment, patient demands based on medical journalism and the internet and the exponential growth of bio-medical technology. Patient empowerment can result in complaints arising in new and complex areas and expert opinion can often differ markedly depending on where on the medical spectrum the experts are aligned. This column lays out some broad-brush principles to assess the adequacy of medical advice in such a climate.

  12. Imaging edges of nanostructured graphene

    DEFF Research Database (Denmark)

    Kling, Jens; Cagliani, Alberto; Booth, T. J.

    Graphene, as the forefather of 2D-materials, attracts much attention due to its extraordinary properties like transparency, flexibility and outstanding high conductivity, together with a thickness of only one atom. However, graphene also possesses no band gap, which makes it unsuitable for many...... electronic applications like transistors. It has been shown theoretically that by nanostructuring pristine graphene, e.g. with regular holes, the electronic properties can be tuned and a band gap introduced. The size, distance and edge termination of these “defects” influence the adaptability....... Such nanostructuring can be done experimentally, but especially characterization at atomic level is a huge challenge. High-resolution TEM (HRTEM) is used to characterize the atomic structure of graphene. We optimized the imaging conditions used for the FEI Titan ETEM. To reduce the knock-on damage of the carbon atoms...

  13. Magnetohydrodynamic stability of tokamak edge plasmas

    International Nuclear Information System (INIS)

    Connor, J.W.; Hastie, R.J.; Wilson, H.R.; Miller, R.L.

    1998-01-01

    A new formalism for analyzing the magnetohydrodynamic stability of a limiter tokamak edge plasma is developed. Two radially localized, high toroidal mode number n instabilities are studied in detail: a peeling mode and an edge ballooning mode. The peeling mode, driven by edge current density and stabilized by edge pressure gradient, has features which are consistent with several properties of tokamak behavior in the high confinement open-quotes Hclose quotes-mode of operation, and edge localized modes (or ELMs) in particular. The edge ballooning mode, driven by the pressure gradient, is identified; this penetrates ∼n 1/3 rational surfaces into the plasma (rather than ∼n 1/2 , expected from conventional ballooning mode theory). Furthermore, there exists a coupling between these two modes and this coupling provides a picture of the ELM cycle

  14. Edge and line detection of complicated and blurred objects

    OpenAIRE

    Haugsdal, Kari

    2010-01-01

    This report deals with edge and line detection in pictures with complicated and/or blurred objects. It explores the alternatives available, in edge detection, edge linking and object recognition. Choice of methods are the Canny edge detection and Local edge search processing combined with regional edge search processing in the form of polygon approximation.

  15. Study of airfoil trailing edge bluntness noise

    DEFF Research Database (Denmark)

    Zhu, Wei Jun; Shen, Wen Zhong; Sørensen, Jens Nørkær

    2010-01-01

    This paper deals with airfoil trailing edge noise with special focus on airfoils with blunt trailing edges. Two methods are employed to calculate airfoil noise: The flow/acoustic splitting method and the semi-empirical method. The flow/acoustic splitting method is derived from compressible Navier...... design or optimization. Calculations from both methods are compared with exist experiments. The airfoil blunt noise is found as a function of trailing edge bluntness, Reynolds number, angle of attack, etc....

  16. Selective Electroless Silver Deposition on Graphene Edges

    DEFF Research Database (Denmark)

    Durhuus, D.; Larsen, M. V.; Andryieuski, Andrei

    2015-01-01

    We demonstrate a method of electroless selective silver deposition on graphene edges or between graphene islands without covering the surface of graphene. Modifications of the deposition recipe allow for decoration of graphene edges with silver nanoparticles or filling holes in damaged graphene...... on silica substrate and thus potentially restoring electric connectivity with minimal influence on the overall graphene electrical and optical properties. The presented technique could find applications in graphene based transparent conductors as well as selective edge functionalization and can be extended...

  17. Discursive Maps at the Edge of Chaos

    Science.gov (United States)

    2017-05-25

    Discursive Maps at the Edge of Chaos A Monograph by Major Mathieu Primeau Canadian Army, Royal Canadian Engineer School of Advanced Military...Master’s Thesis 3. DATES COVERED (From - To) JUN 2016 – MAY 2017 4. TITLE AND SUBTITLE Discursive Maps at the Edge of Chaos 5a. CONTRACT NUMBER 5b...meaning of boundaries and polarize conflict towards violence. The edge of chaos is the fine line between disorder and coherence. Discursive maps

  18. Edge effect on weevils and spiders

    OpenAIRE

    Horváth, R.; Magura, T.; Péter, G.; Tóthmérész, B.

    2002-01-01

    The edge effect on weevils and spiders was tested along oak forest – meadow transects using sweep-net samples at the Síkfökút Project in Hungary. For spiders the species richness was significantly higher in the forest edge than either in the meadow or the forest interior. For weevils the species richness of the forest edge was higher than that of the meadow, but the difference was not statistically significant whereas the species richness of the forest...

  19. Double layers in space

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-07-01

    For more than a decade it has been realised that electrostatic double layers are likely to occur in space. We briefly discuss the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Author)

  20. Double layers in space

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-01-01

    For more than a decade it has been realised that electrostatic double layers are likely to occur in space. The author briefly discusses the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Auth.)

  1. Moveable Leading Edge Device for a Wing

    Science.gov (United States)

    Pitt, Dale M. (Inventor); Eckstein, Nicholas Stephen (Inventor)

    2013-01-01

    A method and apparatus for managing a flight control surface system. A leading edge section on a wing of an aircraft is extended into a deployed position. A deformable section connects the leading edge section to a trailing section. The deformable section changes from a deformed shape to an original shape when the leading edge section is moved into the deployed position. The leading edge section on the wing is moved from the deployed position to an undeployed position. The deformable section changes to the deformed shape inside of the wing.

  2. Visible imaging of edge turbulence in NSTX

    International Nuclear Information System (INIS)

    Zweben, S.; Maqueda, R.; Hill, K.; Johnson, D.

    2000-01-01

    Edge plasma turbulence in tokamaks and stellarators is believed to cause the radical heat and particle flux across the separatrix and into the scrape-off-layers of these devices. This paper describes initial measurements of 2-D space-time structure of the edge density turbulence made using a visible imaging diagnostic in the National Spherical Torus Experiment (NSTX). The structure of the edge turbulence is most clearly visible using a method of gas puff imaging to locally illuminate the edge density turbulence

  3. IMAGE ANALYSIS BASED ON EDGE DETECTION TECHNIQUES

    Institute of Scientific and Technical Information of China (English)

    纳瑟; 刘重庆

    2002-01-01

    A method that incorporates edge detection technique, Markov Random field (MRF), watershed segmentation and merging techniques was presented for performing image segmentation and edge detection tasks. It first applies edge detection technique to obtain a Difference In Strength (DIS) map. An initial segmented result is obtained based on K-means clustering technique and the minimum distance. Then the region process is modeled by MRF to obtain an image that contains different intensity regions. The gradient values are calculated and then the watershed technique is used. DIS calculation is used for each pixel to define all the edges (weak or strong) in the image. The DIS map is obtained. This help as priority knowledge to know the possibility of the region segmentation by the next step (MRF), which gives an image that has all the edges and regions information. In MRF model,gray level l, at pixel location i, in an image X, depends on the gray levels of neighboring pixels. The segmentation results are improved by using watershed algorithm. After all pixels of the segmented regions are processed, a map of primitive region with edges is generated. The edge map is obtained using a merge process based on averaged intensity mean values. A common edge detectors that work on (MRF) segmented image are used and the results are compared. The segmentation and edge detection result is one closed boundary per actual region in the image.

  4. Object detection using categorised 3D edges

    DEFF Research Database (Denmark)

    Kiforenko, Lilita; Buch, Anders Glent; Bodenhagen, Leon

    2015-01-01

    is made possible by the explicit use of edge categories in the feature descriptor. We quantitatively compare our approach with the state-of-the-art template based Linemod method, which also provides an effective way of dealing with texture-less objects, tests were performed on our own object dataset. Our...... categorisation algorithm for describing objects in terms of its different edge types. Relying on edge information allow our system to deal with objects with little or no texture or surface variation. We show that edge categorisation improves matching performance due to the higher level of discrimination, which...

  5. Visible imaging of edge turbulence in NSTX

    International Nuclear Information System (INIS)

    S. Zweben; R. Maqueda; K. Hill; D. Johnson; S. Kaye; H. Kugel; F. Levinton; R. Maingi; L. Roquemore; S. Sabbagh; G. Wurden

    2000-01-01

    Edge plasma turbulence in tokamaks and stellarators is believed to cause the radial heat and particle flux across the separatrix and into the scrape-off-layers of these devices. This paper describes initial measurements of 2-D space-time structure of the edge density turbulence made using a visible imaging diagnostic in the National Spherical Torus Experiment (NSTX). The structure of the edge turbulence is most clearly visible using a method of ''gas puff imaging'' to locally illuminate the edge density turbulence

  6. Double-double effect and coordination number

    International Nuclear Information System (INIS)

    Mioduski, T.

    1992-01-01

    The original method of interpretation together with its theoretical foundations is developed, making it possible to use location and direction of the double-double (tetrad) effect within the Ln and An series to determine the coordination number (CN) complexes of the f-block elements. The method is applied for potentiometric and radiometric equilibrium studies. It has been pointed and that the decisive factor for the direction of the double-double effect in the case of the Gibbs energy variations is a difference in the CN of the f-element ion between the reaction product complex and that for the reaction substrate the ''regular'' effect for a given tetrad is accompanied by decrease in the CN while the ''reverse'' effect by increase in the CN. (author). 122 refs, 5 tabs, 8 figs

  7. Edge passivation induced single-edge ferromagnetism of zigzag MoS_2 nanoribbons

    International Nuclear Information System (INIS)

    Wang, Rui; Sun, Hui; Ma, Ben; Hu, Jingguo; Pan, Jing

    2017-01-01

    We performed density functional theory study on electronic structure, magnetic properties and stability of zigzag MoS_2 nanoribbons (ZMoS_2NRs) with and without oxygen (O) passivation. The bare ZMoS_2NRs are magnetic metal with ferromagnetic edge states, edge passivation decreases their magnetism because of the decrease of edge unsaturated electrons. Obviously, the electronic structure and magnetic properties of ZMoS_2NRs greatly depend on edge states. When both edges are passivated by O atoms, ZMoS_2NRs are nonmagnetic metals. When either edge is passivated by O atoms, the systems exhibit single-edge ferromagnetism and magnetism concentrates on the non-passivated edge. Edge passivation can not only tune the magnetism of ZMoS_2NRs, but also enhance their stability by eliminating dangling bonds. These interesting findings on ZMoS_2NRs may open the possibility of their application in nanodevices and spintronics. - Highlights: • Edge passivation for tuning magnetism of zigzag MoS_2 nanoribbons (ZMoS_2NRs) is proposed. • Edge passivation can tune ZMoS_2NRs from nonmagnetic metal to ferromagnetic metal. • When either edge is passivated, the systems exhibit single-edge ferromagnetic states. • These findings may inspire great interest in the community of ZMoS_2NRs and motivate numerous experimental researches.

  8. Saturn's Rings Edge-on

    Science.gov (United States)

    1995-01-01

    In one of nature's most dramatic examples of 'now-you see-them, now-you-don't', NASA's Hubble Space Telescope captured Saturn on May 22, 1995 as the planet's magnificent ring system turned edge-on. This ring-plane crossing occurs approximately every 15 years when the Earth passes through Saturn's ring plane.For comparison, the top picture was taken by Hubble on December 1, 1994 and shows the rings in a more familiar configuration for Earth observers.The bottom picture was taken shortly before the ring plane crossing. The rings do not disappear completely because the edge of the rings reflects sunlight. The dark band across the middle of Saturn is the shadow of the rings cast on the planet (the Sun is almost 3 degrees above the ring plane.) The bright stripe directly above the ring shadow is caused by sunlight reflected off the rings onto Saturn's atmosphere. Two of Saturn's icy moons are visible as tiny starlike objects in or near the ring plane. They are, from left to right, Tethys (slightly above the ring plane) and Dione.This observation will be used to determine the time of ring-plane crossing and the thickness of the main rings and to search for as yet undiscovered satellites. Knowledge of the exact time of ring-plane crossing will lead to an improved determination of the rate at which Saturn 'wobbles' about its axis (polar precession).Both pictures were taken with Hubble's Wide Field Planetary Camera 2. The top image was taken in visible light. Saturn's disk appears different in the bottom image because a narrowband filter (which only lets through light that is not absorbed by methane gas in Saturn's atmosphere) was used to reduce the bright glare of the planet. Though Saturn is approximately 900 million miles away, Hubble can see details as small as 450 miles across.The Wide Field/Planetary Camera 2 was developed by the Jet Propulsion Laboratory and managed by the Goddard Spaced Flight Center for NASA's Office of Space Science.This image and other images and

  9. Inviscid double wake model for stalled airfoils

    International Nuclear Information System (INIS)

    Marion, L; Ramos-García, N; Sørensen, J N

    2014-01-01

    An inviscid double wake model based on a steady two-dimensional panel method has been developed to predict aerodynamic loads of wind turbine airfoils in the deep stall region. The separated flow is modelled using two constant vorticity sheets which are released at the trailing edge and at the separation point. A calibration of the code through comparison with experiments has been performed using one set of airfoils. A second set of airfoils has been used for the validation of the calibrated model. Predicted aerodynamic forces for a wide range of angles of attack (0 to 90 deg) are in overall good agreement with wind tunnel measurements

  10. Double bowl piston

    Science.gov (United States)

    Meffert, Darrel Henry; Urven, Jr., Roger Leroy; Brown, Cory Andrew; Runge, Mark Harold

    2007-03-06

    A piston for an internal combustion engine is disclosed. The piston has a piston crown with a face having an interior annular edge. The piston also has first piston bowl recessed within the face of the piston crown. The first piston bowl has a bottom surface and an outer wall. A line extending from the interior annular edge of the face and tangent with the outer wall forms an interior angle greater than 90 degrees with the face of the piston. The piston also has a second piston bowl that is centrally located and has an upper edge located below a face of the piston crown.

  11. Competitive edge through technological innovation

    International Nuclear Information System (INIS)

    Gottlieb, M.

    1997-01-01

    The vital role of advanced technology in natural gas cost reduction has been described. Among advanced technologies, seismic, drilling and fracturing technologies have been singled out as being the most important. Access to new supply frontiers (aided by the application of advanced technology), and more effective business strategies were considered as the other most influential factors in efficiently exploiting oil and gas resources. In view of predictions of substantially increased demand, advanced technology is poised to be even more important in the future. With this as background, an examination of the level of investment for the development of advanced technology revealed that energy industry R and D expenditures were lowest among industries in the U.S. (only 0.7 per cent of sales). It was concluded that notwithstanding industry's ability to improve output per R and D dollar invested, the achievement of the necessary technological advancements is a strategic imperative for both the industry and the U.S. as a whole. As far as the industry is concerned, its ability to maintain a competitive edge over competing energy forms, will be determined largely on the basis of its willingness to invest in future advanced technology development. 2 refs., 14 figs

  12. CMS kinematic edge from sbottoms

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Peisi; Wagner, Carlos E. M.

    2015-01-01

    We present two scenarios in the Minimal Supersymmetric Extension of the Standard Model (MSSM) that can lead to an explanation of the excess in the invariant mass distribution of two opposite charged, same flavor leptons, and the corresponding edge at an energy of about 78 GeV, recently reported by the CMS Collaboration. In both scenarios, sbottoms are pair produced, and decay to neutralinos and a b-jet. The heavier neutralinos further decay to a pair of leptons and the lightest neutralino through on-shell sleptons or off-shell neutral gauge bosons. These scenarios are consistent with the current limits on the sbottoms, neutralinos, and sleptons. Assuming that the lightest neutralino is stable we discuss the predicted relic density as well as the implications for darkmatter direct detection. We show that consistency between the predicted and the measured value of the muon anomalous magnetic moment may be obtained in both scenarios. Finally, we define the signatures of these models that may be tested at the 13 TeV run of the LHC

  13. The Human Body Sword

    Directory of Open Access Journals (Sweden)

    Kris Borer

    2010-08-01

    Full Text Available The human body shield problem involves an apparent dilemma for a libertarian, forcing him to choose between his own death and the death of an innocent person. This paper argues that the non-aggression principle permits a forceful response against the property of innocent individuals when a conflict is initiated with that property. In other words, a libertarian may shoot the hostage in order to save himself.

  14. LES tests on airfoil trailing edge serration

    DEFF Research Database (Denmark)

    Zhu, Wei Jun; Shen, Wen Zhong

    2016-01-01

    In the present study, a large number of acoustic simulations are carried out for a low noise airfoil with different Trailing Edge Serrations (TES). The Ffowcs Williams-Hawkings (FWH) acoustic analogy is used for noise prediction at trailing edge. The acoustic solver is running on the platform...

  15. Automatic Edging and Trimming of Hardwood Lumber

    Science.gov (United States)

    D. Earl Kline; Eugene M. Wengert; Philip A. Araman

    1990-01-01

    Studies have shown that there is a potential to increase hardwood lumber value by more than 20 percent through optimum edging and trimming. Even a small portion of this percentage can boost the profitability of hardwood lumber manufacturers substantially. The objective of this research project is to develop an automated system which would assist in correct edging and...

  16. Development of planar detectors with active edge

    International Nuclear Information System (INIS)

    Povoli, M.; Bagolini, A.; Boscardin, M.; Dalla Betta, G.-F.; Giacomini, G.; Vianello, E.; Zorzi, N.

    2011-01-01

    We report on the first batch of planar active edge sensors fabricated at Fondazione Bruno Kessler (Trento, Italy) on the way to the development of full 3D detectors with active edges. The main design and technological aspects are reported, along with selected results from the electrical characterization of detectors and test structures.

  17. Development of planar detectors with active edge

    Energy Technology Data Exchange (ETDEWEB)

    Povoli, M., E-mail: povoli@disi.unitn.it [Dipartimento di Ingegneria e Scienza dell' Informazione, Universita di Trento, Via Sommarive, 14, I-38123 Povo di Trento (Italy); INFN, Sezione di Padova (Gruppo Collegato di Trento) (Italy); Bagolini, A.; Boscardin, M. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy); Dalla Betta, G.-F. [Dipartimento di Ingegneria e Scienza dell' Informazione, Universita di Trento, Via Sommarive, 14, I-38123 Povo di Trento (Italy); INFN, Sezione di Padova (Gruppo Collegato di Trento) (Italy); Giacomini, G.; Vianello, E.; Zorzi, N. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy)

    2011-12-01

    We report on the first batch of planar active edge sensors fabricated at Fondazione Bruno Kessler (Trento, Italy) on the way to the development of full 3D detectors with active edges. The main design and technological aspects are reported, along with selected results from the electrical characterization of detectors and test structures.

  18. Annotated Bibliography of EDGE2D Use

    Energy Technology Data Exchange (ETDEWEB)

    J.D. Strachan and G. Corrigan

    2005-06-24

    This annotated bibliography is intended to help EDGE2D users, and particularly new users, find existing published literature that has used EDGE2D. Our idea is that a person can find existing studies which may relate to his intended use, as well as gain ideas about other possible applications by scanning the attached tables.

  19. Annotated Bibliography of EDGE2D Use

    International Nuclear Information System (INIS)

    Strachan, J.D.; Corrigan, G.

    2005-01-01

    This annotated bibliography is intended to help EDGE2D users, and particularly new users, find existing published literature that has used EDGE2D. Our idea is that a person can find existing studies which may relate to his intended use, as well as gain ideas about other possible applications by scanning the attached tables

  20. Magnetism of zigzag edge phosphorene nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Zhili, E-mail: zlzhu@zzu.edu.cn, E-mail: jiayu@zzu.edu.cn; Li, Chong; Yu, Weiyang; Chang, Dahu; Sun, Qiang; Jia, Yu, E-mail: zlzhu@zzu.edu.cn, E-mail: jiayu@zzu.edu.cn [International Joint Research Laboratory for Quantum Functional Materials of Henan, and School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001 (China)

    2014-09-15

    We have investigated, by means of ab initio calculations, the electronic and magnetic structures of zigzag edge phosphorene nanoribbons (ZPNRs) with various widths. The stable magnetic state was found in pristine ZPNRs by allowing the systems to be spin-polarized. The ground state of pristine ZPNRs prefers ferromagnetic order in the same edge but antiferromagnetic order between two opposite edges. The magnetism arises from the dangling bond states as well as edge localized π-orbital states. The presence of a dangling bond is crucial to the formation of the magnetism of ZPNRs. The hydrogenated ZPNRs get nonmagnetic semiconductors with a direct band gap. While, the O-saturated ZPNRs show magnetic ground states due to the weak P-O bond in the ribbon plane between the p{sub z}-orbitals of the edge O and P atoms.

  1. Edge separation using diffraction anomalous fine structure

    International Nuclear Information System (INIS)

    Ravel, B.; Bouldin, C.E.; Renevier, H.; Hodeau, J.L.; Berar, J.F.

    1999-01-01

    We exploit the crystallographic sensitivity of the Diffraction Anomalous Fine-Structure (DAFS) measurement to separate the fine structure contributions of different atomic species with closely spaced resonant energies. In BaTiO 3 the Ti K edge and Ba Lm edges are separated by 281 eV, or about 8.2 Angstrom -1 ), thus severely limiting the information content of the Ti K edge signal. Using the site selectivity of DAFS we can separate the two fine structure spectra using an iterative Kramers-Kronig method, thus extending the range of the Ti K edge spectrum. This technique has application to many rare earth/transition metal compounds, including many magnetic materials of technological significance for which K and L edges overlap in energy. (au)

  2. Elastically Deformable Side-Edge Link for Trailing-Edge Flap Aeroacoustic Noise Reduction

    Science.gov (United States)

    Khorrami, Mehdi R. (Inventor); Lockard, David P. (Inventor); Moore, James B. (Inventor); Su, Ji (Inventor); Turner, Travis L. (Inventor); Lin, John C. (Inventor); Taminger, Karen M. (Inventor); Kahng, Seun K. (Inventor); Verden, Scott A. (Inventor)

    2014-01-01

    A system is provided for reducing aeroacoustic noise generated by an aircraft having wings equipped with trailing-edge flaps. The system includes a plurality of elastically deformable structures. Each structure is coupled to and along one of the side edges of one of the trailing-edge flaps, and is coupled to a portion of one of the wings that is adjacent to the one of the side edges. The structures elastically deform when the trailing-edge flaps are deployed away from the wings.

  3. Localized Edge Vibrations and Edge Reconstruction by Joule Heating in Graphene Nanostructures

    DEFF Research Database (Denmark)

    Engelund, Mads; Fürst, Joachim Alexander; Jauho, Antti-Pekka

    2010-01-01

    Control of the edge topology of graphene nanostructures is critical to graphene-based electronics. A means of producing atomically smooth zigzag edges using electronic current has recently been demonstrated in experiments [Jia et al., Science 323, 1701 (2009)]. We develop a microscopic theory...... for current-induced edge reconstruction using density functional theory. Our calculations provide evidence for localized vibrations at edge interfaces involving unpassivated armchair edges. We demonstrate that these vibrations couple to the current, estimate their excitation by Joule heating, and argue...

  4. Edge-entanglement spectrum correspondence in a nonchiral topological phase and Kramers-Wannier duality

    Science.gov (United States)

    Ho, Wen Wei; Cincio, Lukasz; Moradi, Heidar; Gaiotto, Davide; Vidal, Guifre

    2015-03-01

    In a system with chiral topological order, there is a remarkable correspondence between the edge and entanglement spectra: the low-energy spectrum of the system in the presence of a physical edge coincides with the lowest part of the entanglement spectrum (ES) across a virtual cut of the system into two parts, up to rescaling and shifting. This correspondence is believed to be due to the existence of protected gapless edge modes. In this paper, we explore whether the edge-entanglement spectrum correspondence extends to nonchiral topological phases, where there are no protected gapless edge modes. Specifically, we consider the Wen-plaquette model, which is equivalent to the Kitaev toric code model and has Z2 topological order (quantum double of Z2) . The unperturbed Wen-plaquette model displays an exact correspondence: both the edge and entanglement spectra within each topological sector a (a =1 ,⋯,4 ) are flat and equally degenerate. Here, we show, through a detailed microscopic calculation, that in the presence of generic local perturbations: (i) the effective degrees of freedom for both the physical edge and the entanglement cut consist of a (spin-1 /2 ) spin chain, with effective Hamiltonians Hedgea and Henta, respectively, both of which have a Z2 symmetry enforced by the bulk topological order; (ii) there is in general no match between the low-energy spectra of Hedgea and Henta, that is, there is no edge-ES correspondence. However, if supplement the Z2 topological order with a global symmetry (translational invariance along the edge/entanglement cut), i.e., by considering the Wen-plaquette model as a symmetry-enriched topological phase (SET), then there is a finite domain in Hamiltonian space in which both Hedgea and Henta realize the critical Ising model, whose low-energy effective theory is the c =1 /2 Ising CFT. This is achieved because the presence of the global symmetry implies that the effective degrees of freedom of both the edge and entanglement

  5. Observing Double Stars

    Science.gov (United States)

    Genet, Russell M.; Fulton, B. J.; Bianco, Federica B.; Martinez, John; Baxter, John; Brewer, Mark; Carro, Joseph; Collins, Sarah; Estrada, Chris; Johnson, Jolyon; Salam, Akash; Wallen, Vera; Warren, Naomi; Smith, Thomas C.; Armstrong, James D.; McGaughey, Steve; Pye, John; Mohanan, Kakkala; Church, Rebecca

    2012-05-01

    Double stars have been systematically observed since William Herschel initiated his program in 1779. In 1803 he reported that, to his surprise, many of the systems he had been observing for a quarter century were gravitationally bound binary stars. In 1830 the first binary orbital solution was obtained, leading eventually to the determination of stellar masses. Double star observations have been a prolific field, with observations and discoveries - often made by students and amateurs - routinely published in a number of specialized journals such as the Journal of Double Star Observations. All published double star observations from Herschel's to the present have been incorporated in the Washington Double Star Catalog. In addition to reviewing the history of visual double stars, we discuss four observational technologies and illustrate these with our own observational results from both California and Hawaii on telescopes ranging from small SCTs to the 2-meter Faulkes Telescope North on Haleakala. Two of these technologies are visual observations aimed primarily at published "hands-on" student science education, and CCD observations of both bright and very faint doubles. The other two are recent technologies that have launched a double star renaissance. These are lucky imaging and speckle interferometry, both of which can use electron-multiplying CCD cameras to allow short (30 ms or less) exposures that are read out at high speed with very low noise. Analysis of thousands of high speed exposures allows normal seeing limitations to be overcome so very close doubles can be accurately measured.

  6. Formation of double layers

    International Nuclear Information System (INIS)

    Leung, P.; Wong, A.Y.; Quon, B.H.

    1981-01-01

    Experiments on both stationary and propagating double layers and a related analytical model are described. Stationary double layers were produced in a multiple plasma device, in which an electron drift current was present. An investigation of the plasma parameters for the stable double layer condition is described. The particle distribution in the stable double layer establishes a potential profile, which creates electron and ion beams that excite plasma instabilities. The measured characteristics of the instabilities are consistent with the existence of the double layer. Propagating double layers are formed when the initial electron drift current is large. Ths slopes of the transition region increase as they propagate. A physical model for the formation of a double layer in the experimental device is described. This model explains the formation of the low potential region on the basis of the space charge. This space charge is created by the electron drift current. The model also accounts for the role of ions in double layer formation and explains the formation of moving double layers. (Auth.)

  7. Secrecy and misguided policy

    Energy Technology Data Exchange (ETDEWEB)

    Rossin, A D [Center for International Security and Cooperation, Stanford, California (United States)

    2001-07-01

    The atomic bomb was born in secrecy. After the war, scientists and statesmen committed themselves to develop the promise of nuclear energy without the proliferation of nuclear weapons. The most obvious tool available to them was secrecy. But secrecy was not the sword that could easily be beaten into the plowshare. It proved to be a double-edged sword. It could not stop the spread of basic scientific information, and it turned out to be a weapon for marketing information to promote political aims. It served that purpose in promoting President Carter policy to stop reprocessing of spent fuel. (author)

  8. Secrecy and misguided policy

    International Nuclear Information System (INIS)

    Rossin, A.D.

    2001-01-01

    The atomic bomb was born in secrecy. After the war, scientists and statesmen committed themselves to develop the promise of nuclear energy without the proliferation of nuclear weapons. The most obvious tool available to them was secrecy. But secrecy was not the sword that could easily be beaten into the plowshare. It proved to be a double-edged sword. It could not stop the spread of basic scientific information, and it turned out to be a weapon for marketing information to promote political aims. It served that purpose in promoting President Carter policy to stop reprocessing of spent fuel. (author)

  9. Development of X-ray microcalorimeters using transition edge sensors

    International Nuclear Information System (INIS)

    Ukibe, M; Hirayama, F.; Tanaka, K.; Koyanagi, M.; Ohkubo, M.; Kobayashi, N.; Morooka, T.; Chinone, K.

    2000-01-01

    We are developing X-ray microcalorimeters using superconducting transition edge sensors (TESs), which can be operated at relatively high temperatures in a 3 He cryostat, and DC-SQUID current amplifiers to realize an X-ray spectroscopy with a high energy resolution and a high counting rate. The TESs are proximity bilayers of Ti and Au on SiN x membranes with 500-1000 nm thicknesses. The typical TES has a T c value of 0.4 K and a ΔT c value of 2 mK. Two types of DC-SQUID amplifiers were developed; the single stage with 200-series SQUIDs and the double stage with an input SQUID and 50-series SQUIDs. The X-ray detection experiment is in progress. (author)

  10. Edge-functionalization of armchair graphene nanoribbons with pentagonal-hexagonal edge structures.

    Science.gov (United States)

    Ryou, Junga; Park, Jinwoo; Kim, Gunn; Hong, Suklyun

    2017-06-21

    Using density functional theory calculations, we have studied the edge-functionalization of armchair graphene nanoribbons (AGNRs) with pentagonal-hexagonal edge structures. While the AGNRs with pentagonal-hexagonal edge structures (labeled (5,6)-AGNRs) are metallic, the edge-functionalized (5,6)-AGNRs with substitutional atoms opens a band gap. We find that the band structures of edge-functionalized (5,6)-N-AGNRs by substitution resemble those of defect-free (N-1)-AGNR at the Γ point, whereas those at the X point show the original ones of the defect-free N-AGNR. The overall electronic structures of edge-functionalized (5,6)-AGNRs depend on the number of electrons, supplied by substitutional atoms, at the edges of functionalized (5,6)-AGNRs.

  11. Timing performances and edge effects of detectors worked from 6-in. silicon slices

    International Nuclear Information System (INIS)

    Aiello, S.; Anzalone, A.; Cardella, G.; Cavallaro, Sl.; De Filippo, E.; Di Pietro, A.; Femino, S.; Geraci, M.; Giustolisi, F.; Guazzoni, P.; Iacono Manno, M.; Lanzalone, G.; Lanzano, G.; Lo Nigro, S.; Musumarra, A.; Pagano, A.; Papa, M.; Pirrone, S.; Politi, G.; Porto, F.; Rizzo, F.; Sambataro, S.; Sperduto, M.L.; Sutera, C.; Zetta, L.

    1997-01-01

    Prototypes of new passivated implanted planar silicon detectors, obtained for the first time from 6 in. silicon slices, have been tested. The time and energy resolutions have been studied as a function of the type and energy of the detected particles, in order to test the performances of these detectors for time of flight measurements in the Chimera project. Some problems arising from edge effects observed in double-pad detectors have been solved by using a guard ring. (orig.)

  12. Power deposition on misaligned edges in COMPASS

    Directory of Open Access Journals (Sweden)

    R. Dejarnac

    2017-08-01

    Full Text Available If the decision is made not to apply a toroidal chamfer to tungsten monoblocks at ITER divertor vertical targets, exposed leading edges will arise as a result of assembly tolerances between adjacent plasma-facing components. Then, the advantage of glancing magnetic field angles for spreading plasma heat flux on top surfaces is lost at the misaligned edges with an interaction occurring at near normal incidence, which can drive melting for the expected inter-ELM heat fluxes. A dedicated experiment has been performed on the COMPASS tokamak to thoroughly study power deposition on misaligned edges using inner-wall limited discharges on a special graphite tile presenting gaps and leading edges directly viewed by a high resolution infra-red camera. The parallel power flux deducted from the unperturbed measurement far from the gap is fully consistent with the observed temperature increase at the leading edge, respecting the power balance. All the power flowing into the gap is deposited at the leading edge and no mitigation factor is required to explain the thermal response. Particle-in-cell simulations show that the ion Larmor smoothing effect is weak and that the power deposition on misaligned edges is well described by the optical approximation because of an electron dominated regime associated with non-ambipolar parallel current flow.

  13. AliEn - EDG Interoperability in ALICE

    CERN Document Server

    Bagnasco, S; Buncic, P; Carminati, F; Cerello, P G; Saiz, P

    2003-01-01

    AliEn (ALICE Environment) is a GRID-like system for large scale job submission and distributed data management developed and used in the context of ALICE, the CERN LHC heavy-ion experiment. With the aim of exploiting upcoming Grid resources to run AliEn-managed jobs and store the produced data, the problem of AliEn-EDG interoperability was addressed and an in-terface was designed. One or more EDG (European Data Grid) User Interface machines run the AliEn software suite (Cluster Monitor, Storage Element and Computing Element), and act as interface nodes between the systems. An EDG Resource Broker is seen by the AliEn server as a single Computing Element, while the EDG storage is seen by AliEn as a single, large Storage Element; files produced in EDG sites are registered in both the EDG Replica Catalogue and in the AliEn Data Catalogue, thus ensuring accessibility from both worlds. In fact, both registrations are required: the AliEn one is used for the data management, the EDG one to guarantee the integrity and...

  14. Edge-Disjoint Fibonacci Trees in Hypercube

    Directory of Open Access Journals (Sweden)

    Indhumathi Raman

    2014-01-01

    Full Text Available The Fibonacci tree is a rooted binary tree whose number of vertices admit a recursive definition similar to the Fibonacci numbers. In this paper, we prove that a hypercube of dimension h admits two edge-disjoint Fibonacci trees of height h, two edge-disjoint Fibonacci trees of height h-2, two edge-disjoint Fibonacci trees of height h-4 and so on, as subgraphs. The result shows that an algorithm with Fibonacci trees as underlying data structure can be implemented concurrently on a hypercube network with no communication latency.

  15. Natural and artificial spectral edges in exoplanets

    Science.gov (United States)

    Lingam, Manasvi; Loeb, Abraham

    2017-09-01

    Technological civilizations may rely upon large-scale photovoltaic arrays to harness energy from their host star. Photovoltaic materials, such as silicon, possess distinctive spectral features, including an 'artificial edge' that is characteristically shifted in wavelength shortwards of the 'red edge' of vegetation. Future observations of reflected light from exoplanets would be able to detect both natural and artificial edges photometrically, if a significant fraction of the planet's surface is covered by vegetation or photovoltaic arrays, respectively. The stellar energy thus tapped can be utilized for terraforming activities by transferring heat and light from the day side to the night side on tidally locked exoplanets, thereby producing detectable artefacts.

  16. Adobe Edge Animate CC for dummies

    CERN Document Server

    Rohde, Michael

    2013-01-01

    The easy way to build HTML5 mobile and web apps using Adobe's new Edge Animate CC Edge Animate CC is an approachable WYSIWYG alternative for leveraging the power of languages like HTML5, CSS3, and JavaScript to design and develop for the web and mobile devices, even if you have no programming experience. Written by Michael Rohde, the book calls on this seasoned web developer's wealth of experience using Edge Animate CC, and a companion website includes all code from the book to help you apply what you learn as you go. Features an easy-to-use interface, with a propert

  17. Edge-Matching Problems with Rotations

    DEFF Research Database (Denmark)

    Ebbesen, Martin; Fischer, Paul; Witt, Carsten

    2011-01-01

    Edge-matching problems, also called puzzles, are abstractions of placement problems with neighborhood conditions. Pieces with colored edges have to be placed on a board such that adjacent edges have the same color. The problem has gained interest recently with the (now terminated) Eternity II...... puzzle, and new complexity results. In this paper we consider a number of settings which differ in size of the puzzles and the manipulations allowed on the pieces. We investigate the effect of allowing rotations of the pieces on the complexity of the problem, an aspect that is only marginally treated so...

  18. Double deflation and aggregation

    NARCIS (Netherlands)

    Dietzenbacher, Erik; Hoen, A.R.

    Published input-output tables in constant prices are relatively scarce. Therefore, input-output tables often have to be deflated by the practitioners themselves. The method of double deflation is used predominantly for this purpose. The present paper shows that the double-deflation method is subject

  19. Edge enhancement improves disruptive camouflage by emphasising false edges and creating pictorial relief.

    Science.gov (United States)

    Egan, John; Sharman, Rebecca J; Scott-Brown, Kenneth C; Lovell, Paul George

    2016-12-06

    Disruptive colouration is a visual camouflage composed of false edges and boundaries. Many disruptively camouflaged animals feature enhanced edges; light patches are surrounded by a lighter outline and/or a dark patches are surrounded by a darker outline. This camouflage is particularly common in amphibians, reptiles and lepidopterans. We explored the role that this pattern has in creating effective camouflage. In a visual search task utilising an ultra-large display area mimicking search tasks that might be found in nature, edge enhanced disruptive camouflage increases crypsis, even on substrates that do not provide an obvious visual match. Specifically, edge enhanced camouflage is effective on backgrounds both with and without shadows; i.e. this is not solely due to background matching of the dark edge enhancement element with the shadows. Furthermore, when the dark component of the edge enhancement is omitted the camouflage still provided better crypsis than control patterns without edge enhancement. This kind of edge enhancement improved camouflage on all background types. Lastly, we show that edge enhancement can create a perception of multiple surfaces. We conclude that edge enhancement increases the effectiveness of disruptive camouflage through mechanisms that may include the improved disruption of the object outline by implying pictorial relief.

  20. Flow distortion at a dense forest edge

    DEFF Research Database (Denmark)

    Dellwik, Ebba; Bingöl, Ferhat; Mann, Jakob

    2014-01-01

    The flow near tall forest edges is complex, yet poorly described. A field experiment using two meteorological masts equipped with sonic anemometers and a horizontally staring lidar was performed upwind and downwind of the interface between an open flat farmland and a tall (hc = 24 m) beech forest......, relative to the measurements upwind of the edge. The lidar data taken at several positions between the masts at 1.25hc show that the minimum wind speed occurred just upwind of the edge. At the 1.25hc level, at the forest mast, the momentum flux (\\documentclass...... qualitatively be explained with the concept of eddy‐blocking by the canopy top, which could also explain the observed increase in lateral variance and the decrease in the vertical variance. Despite the short distance to the edge of approximately 1.5hc, the beginning of a new internal boundary layer was visible...

  1. Floquet edge states in germanene nanoribbons

    KAUST Repository

    Tahir, Muhammad; Zhang, Qingyun; Schwingenschlö gl, Udo

    2016-01-01

    We theoretically demonstrate versatile electronic properties of germanene monolayers under circularly, linearly, and elliptically polarized light. We show for the high frequency regime that the edge states can be controlled by tuning the amplitude

  2. Edge energies and shapes of nanoprecipitates.

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, John C.

    2006-01-01

    In this report we present a model to explain the size-dependent shapes of lead nano-precipitates in aluminum. Size-dependent shape transitions, frequently observed at nanolength scales, are commonly attributed to edge energy effects. This report resolves an ambiguity in the definition and calculation of edge energies and presents an atomistic calculation of edge energies for free clusters. We also present a theory for size-dependent shapes of Pb nanoprecipitates in Al, introducing the concept of ''magic-shapes'' defined as precipitate shapes having near zero elastic strains when inserted into similarly shaped voids in the Al matrix. An algorithm for constructing a complete set of magic-shapes is presented. The experimental observations are explained by elastic strain energies and interfacial energies; edge energies play a negligible role. We replicate the experimental observations by selecting precipitates having magic-shapes and interfacial energies less than a cutoff value.

  3. Thermal stability of the tokamak plasma edge

    International Nuclear Information System (INIS)

    Stacey, W.M.

    1997-01-01

    The general linear, fluid, thermal instability theory for the plasma edge has been extended. An analysis of a two-dimensional fluid model of the plasma edge has identified the importance of many previously unappreciated phenomena associated with parallel and gyroviscous forces in the presence of large radial gradients, with large radial or parallel flows, with the temperature dependence of transport coefficients, and with the coupling of temperature, flow and density perturbations. The radiative condensation effect is generalized to include a further destabilizing condensation effect associated with radial heat conduction. Representative plasma edge neutral and impurity densities are found to be capable of driving thermal instabilities in the edge transport barrier and radiative mantle, respectively. (author)

  4. Folded membrane dialyzer with mechanically sealed edges

    Energy Technology Data Exchange (ETDEWEB)

    Markley, F.W.

    A semipermeable membrane is folded in accordion fashion to form a stack of pleats and the edges are sealed so as to isolate the opposite surfaces of the membrane. The stack is contained within a case that provides ports for flow of blood in contact with one surface of the membrane through channels formed by the pleats and also provides ports for flow of a dialysate through channels formed by the pleats in contact with the other surface of the membrane. The serpentine side edges of the membrane are sealed by a solidified plastic material, whereas effective mechanical means are provided to seal the end edges of the folded membrane. The mechanical means include a clamping strip which biases case sealing flanges into a sealed relationship with end portions of the membrane near the end edges, which portions extend from the stack and between the sealing flanges.

  5. Cover Art: River's Edge: Downward, Outward, Upward

    Directory of Open Access Journals (Sweden)

    Jonee Kulman Brigham

    2017-10-01

    Full Text Available Artist's Statement for the cover art of IJPS volume 4, issue 3: River's Edge: Downward, Outward, Upward, 2015. Mixed Media: photograph, inkjet printed on presentation matte of colored pencil over photograph.

  6. Numerical simulation of edge plasma in tokamak

    International Nuclear Information System (INIS)

    Chen Yiping; Qiu Lijian

    1996-02-01

    The transport process and transport property of plasma in edge layer of Tokamak are simulated by solving numerically two-dimensional and multi-fluid plasma transport equations using suitable simulation code. The simulation results can show plasma parameter distribution characteristics in the area of edge layer, especially the characteristics near the first wall and divertor target plate. The simulation results play an important role in the design of divertor and first wall of Tokamak. (2 figs)

  7. Edge on Impact Simulations and Experiments

    OpenAIRE

    Leavy, R. Brian; Clayton, John D.; Strack, O. Erik; Brannon, Rebecca M.; Strassburger, Elmar

    2013-01-01

    In the quest to understand damage and failure of ceramics in ballistic events, simplified experiments have been developed to benchmark behavior. One such experiment is known as edge on impact (EOI). In this experiment, an impactor strikes the edge of a thin square plate, and damage and cracking that occur on the free surface are captured in real time with high speed photography. If the material of interest is transparent, additional information regarding damage and wave mechanics within the s...

  8. Integrated core-edge-divertor modeling studies

    International Nuclear Information System (INIS)

    Stacey, W.M.

    2001-01-01

    An integrated calculation model for simulating the interaction of physics phenomena taking place in the plasma core, in the plasma edge and in the SOL and divertor of tokamaks has been developed and applied to study such interactions. The model synthesises a combination of numerical calculations (1) the power and particle balances for the core plasma, using empirical confinement scaling laws and taking into account radiation losses (2), the particle, momentum and power balances in the SOL and divertor, taking into account the effects of radiation and recycling neutrals, (3) the transport of feeling and recycling neutrals, explicitly representing divertor and pumping geometry, and (4) edge pedestal gradient scale lengths and widths, evaluation of theoretical predictions (5) confinement degradation due to thermal instabilities in the edge pedestals, (6) detachment and divertor MARFE onset, (7) core MARFE onsets leading to a H-L transition, and (8) radiative collapse leading to a disruption and evaluation of empirical fits (9) power thresholds for the L-H and H-L transitions and (10) the width of the edge pedestals. The various components of the calculation model are coupled and must be iterated to a self-consistent convergence. The model was developed over several years for the purpose of interpreting various edge phenomena observed in DIII-D experiments and thereby, to some extent, has been benchmarked against experiment. Because the model treats the interactions of various phenomena in the core, edge and divertor, yet is computationally efficient, it lends itself to the investigation of the effects of different choices of various edge plasma operating conditions on overall divertor and core plasma performance. Studies of the effect of feeling location and rate, divertor geometry, plasma shape, pumping and over 'edge parameters' on core plasma properties (line average density, confinement, density limit, etc.) have been performed for DIII-D model problems. A

  9. Presheath profiles in simulated tokamak edge plasmas

    International Nuclear Information System (INIS)

    LaBombard, B.; Conn, R.W.; Hirooka, Y.; Lehmer, R.; Leung, W.K.; Nygren, R.E.; Ra, Y.; Tynan, G.

    1988-04-01

    The PISCES plasma surface interaction facility at UCLA generates plasmas with characteristics similar to those found in the edge plasmas of tokamaks. Steady state magnetized plasmas produced by this device are used to study plasma-wall interaction phenomena which are relevant to tokamak devices. We report here progress on some detailed investigations of the presheath region that extends from a wall surface into these /open quotes/simulated tokamak/close quotes/ edge plasma discharges along magnetic field lines

  10. Double-grating polychromator for laser-aided plasma diagnostics

    International Nuclear Information System (INIS)

    Mukhin, E.E.; Razdobarin, G.T.; Semenov, V.V.; Shilnikov, A.N.; Sukhanov, V.L.; Tolstjakov, S.Yu.; Kochergin, M.M.; Mihailovskij, Yu.K.; Bakh, L.I.

    2004-01-01

    A wide bandpass double-grating polychromator with high rejection and high transmission has been designed and manufactured for laser-aided plasma diagnostics. The special mount utilizes subtractive dispersion in the second stage of the double polychromator such that the larger dispersion of the second stage is reduced by that of the first stage. This affects the intensity of the stray light background at the laser wavelength. The background at the edge of the laser line was measured at 10 -5 of the light incident on the input slit. At the short end of the 200 nm bandpass, the stray light relative intensity approached 10 -7

  11. What's happening at the edge of tokamaks

    International Nuclear Information System (INIS)

    Crandall, D.H.

    1987-01-01

    Handling the power deposition at the walls of a plasma fusion device and controlling the particle fueling of the plasma originated the interest in the edge of the plasma by magnetic fusion scientists. Recently this interest has intensified because of clear evidence that the quality of the central plasma confinement depends in unexpected ways on details of how the edge plasma is managed. Significant efforts are being pursued to understand and exploit the improved plasma confinement observed in the 'H-mode' obtained with divertors and in the 'super-shots' obtained with low neutral particle flux from the edge of TFTR limiter plasmas. The controls, that determine whether or not these well-confined plasmas are obtained, are applied in the edge plasma where a wealth of atomic and molecular processes occur. A qualitative overview of current research related to plasma edge and desirable features is presented to guide thoughts about atomic processes to be included in modeling and interpreting the plasma edge of tokamaks. (orig.)

  12. Unsteady phenomena in the edge tone

    International Nuclear Information System (INIS)

    Paal, G.; Vaik, I.

    2007-01-01

    Despite its geometrical simplicity, the edge tone displays a remarkably complex behaviour. A plane jet oscillates around the wedge-shaped object with a relatively stable frequency and under certain circumstances emits an audible tone. This configuration plays a central role in the sound production of several wind instruments but occurs in industrial situations too. The flow exhibits various interesting nonlinear phenomena reported in the literature which are not entirely explained. In this paper, detailed high precision numerical simulations of the flow are reported under various conditions. Several phenomena are reproduced in agreement with the literature such as the existence of 'stages', the dependence of oscillation frequency on the outflow velocity and the orifice-edge distance within one stage, the pressure distribution on the edge surface, etc. A criterion for the appropriate time step for constant accuracy has been derived. The location of force action is surprisingly stable; it remains in a very narrow region of the wedge surface independently of the Reynolds number and the orifice-edge distance but it is much further behind the edge tip than reported in the literature. The various stages can coexist in different ways: jumping back and forth between stages or being superposed on each other. Regardless of the form, the first stage continues to be dominant even when the second and third stage appears. The question of disturbance propagation velocity and disturbance wavelength is also investigated. The development of higher harmonics of a single stage along the orifice-edge tip distance is presented

  13. Edge effect correction using ion beam figuring.

    Science.gov (United States)

    Yang, Bing; Xie, Xuhui; Li, Furen; Zhou, Lin

    2017-11-10

    The edge effect is regarded as one of the most difficult technical issues for fabricating large primary mirrors, as it can greatly reduce the key performance of the optical system. Ion beam figuring (IBF) has the advantage of no edge effect, so we can use it to remove high points on the edge and improve surface accuracy. The edge local correction method (ELCM) of IBF processes only the surface edge zone, and is very different from the current full caliber figuring method (FCFM). Therefore, it is necessary to study the ELCM of IBF. In this paper, the key factors of ELCM are analyzed, such as dwell time algorithm, edge data extension methods, and the outward dimension of the starting figuring point. At the same time, the distinctions between ELCM and FCFM are compared. Finally, a 142 mm diameter fused silica mirror is fabricated to verify the validity of the theoretical of ELCM. The experimental results indicate that the figuring precision and efficiency can be obviously improved by ELCM.

  14. Edge subdivision and edge multisubdivision versus some domination related parameters in generalized corona graphs

    Directory of Open Access Journals (Sweden)

    Magda Dettlaff

    2016-01-01

    Full Text Available Given a graph \\(G=(V,E\\, the subdivision of an edge \\(e=uv\\in E(G\\ means the substitution of the edge \\(e\\ by a vertex \\(x\\ and the new edges \\(ux\\ and \\(xv\\. The domination subdivision number of a graph \\(G\\ is the minimum number of edges of \\(G\\ which must be subdivided (where each edge can be subdivided at most once in order to increase the domination number. Also, the domination multisubdivision number of \\(G\\ is the minimum number of subdivisions which must be done in one edge such that the domination number increases. Moreover, the concepts of paired domination and independent domination subdivision (respectively multisubdivision numbers are defined similarly. In this paper we study the domination, paired domination and independent domination (subdivision and multisubdivision numbers of the generalized corona graphs.

  15. Transaortic Alfieri Edge-to-Edge Repair for Functional Mitral Regurgitation.

    Science.gov (United States)

    Imasaka, Ken-Ichi; Tayama, Eiki; Morita, Shigeki; Toriya, Ryohei; Tomita, Yukihiro

    2018-03-01

    There is controversy about handling functional mitral regurgitation in patients undergoing aortic valve or proximal aortic operations. We describe a transaortic Alfieri edge-to-edge repair for functional mitral regurgitation that reduces operative excessive invasion and prolonged cardiopulmonary bypass time. Between May 2013 and December 2016, 10 patients underwent transaortic Alfieri edge-to-edge mitral repair. There were no operative deaths. The severity of mitral regurgitation immediately after the operation by transesophageal echocardiography was none or trivial in all patients. A transaortic Alfieri edge-to-edge repair for functional mitral regurgitation is a simple and safe approach. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  16. Age and growth of the sword razor clam Ensis arcuatus in the Ría de Pontevedra (NW Spain): Influence of environmental parameters

    Science.gov (United States)

    Hernández-Otero, A.; Gaspar, M. B.; Macho, G.; Vázquez, E.

    2014-01-01

    The sword razor clam Ensis arcuatus is the most important commercial species of razor clam in Spain, and its fishery in the Ría de Pontevedra (Galicia, NW Spain) is the most productive. Despite the economic importance of this species, information on its biology is scarce. This study reports shell morphometric relationships, age, and growth rates of E. arcuatus in three fishing beds in the Ría de Pontevedra (Brensa, Bueu and Ons, located in respectively the inner, middle and outer zones of the ria), providing the first estimates of growth parameters for the species in the Iberian Peninsula. Growth was estimated by examination of surface growth rings and internal shell microgrowth patterns (acetate peel technique) that proved to be the most suitable method for growth estimate. Growth of E. arcuatus was slower in Bueu (L∞ = 140.4, k = 0.40) followed by Brensa (L∞ = 151.91, k = 0.40) and Ons (L∞ = 172.7, k = 0.33), and the clams reached commercial size in 1.7, 2.3 and 2.8 years in Ons, Brensa and Bueu, respectively. The differences in growth between sites in relation to environmental parameters are evaluated and the implications for the razor clam fishery are discussed.

  17. Topologically protected edge states for out-of-plane and in-plane bulk elastic waves

    Science.gov (United States)

    Huo, Shao-Yong; Chen, Jiu-Jiu; Huang, Hong-Bo

    2018-04-01

    Topological phononic insulators (TPnIs) show promise for application in the manipulation of acoustic waves for the design of low-loss transmission and perfectly integrated communication devices. Since solid phononic crystals exist as a transverse polarization mode and a mixed longitudinal-transverse polarization mode, the realization of topological edge states for both out-of-plane and in-plane bulk elastic waves is desirable to enhance the controllability of the edge waves in solid systems. In this paper, a two-dimensional (2D) solid/solid hexagonal-latticed phononic system that simultaneously supports the topologically protected edge states for out-of-plane and in-plane bulk elastic waves is investigated. Firstly, two pairs of two-fold Dirac cones, respectively corresponding to the out-of-plane and in-plane waves, are obtained at the same frequency by tuning the crystal parameters. Then, a strategy of zone folding is invoked to form double Dirac cones. By shrinking and expanding the steel scatterer, the lattice symmetry is broken, and band inversions induced, giving rise to an intriguing topological phase transition. Finally, the topologically protected edge states for both out-of-plane and in-plane bulk elastic waves, which can be simultaneously located at the frequency range from 1.223 to 1.251 MHz, are numerically observed. Robust pseudospin-dependent elastic edge wave propagation along arbitrary paths is further demonstrated. Our results will significantly broaden its practical application in the engineering field.

  18. Further results for crack-edge mappings by ray methods

    International Nuclear Information System (INIS)

    Norris, A.N.; Achenbach, J.D.; Ahlberg, L.; Tittman, B.R.

    1984-01-01

    This chapter discusses further extensions of the local edge mapping method to the pulse-echo case and to configurations of water-immersed specimens and transducers. Crack edges are mapped by the use of arrival times of edge-diffracted signals. Topics considered include local edge mapping in a homogeneous medium, local edge mapping algorithms, local edge mapping through an interface, and edge mapping through an interface using synthetic data. Local edge mapping is iterative, with two or three iterations required for convergence

  19. Congenital maxillary double lip

    Directory of Open Access Journals (Sweden)

    Dinesh Singh Chauhan

    2012-01-01

    Full Text Available Double lip, also referred to as "macrocheilia," is a rare anomaly which affects the upper lip more commonly than the lower lip. It consists of a fold of excess or redundant hypertrophic tissue on the mucosal side of the lip. The congenital double lip is believed to be present at birth and becomes more prominent after eruption of teeth. It affects esthetics and also interferes with speech and mastication. Simple surgical excision produces good functional and cosmetic results. We report a case of a non-syndromic congenital maxillary double lip in a 21-year-old male patient.

  20. On graphs double-critical with respect to the colouring number

    DEFF Research Database (Denmark)

    Pedersen, Anders Sune; Kriesell, Matthias

    2015-01-01

    The colouring number col(G) of a graph $G$ is the smallest integer k for which there is an ordering of the vertices of G such that when removing the vertices of G in the specified order no vertex of degree more than k-1 in the remaining graph is removed at any step. An edge e of a graph G is said...... with the ratio of double-col-critical edges between 1- \\epsilon and 1....

  1. Forests on the edge: Microenvironmental drivers of carbon cycle response to edge effects

    Science.gov (United States)

    Reinmann, A.; Hutyra, L.; Smith, I. A.; Thompson, J.

    2017-12-01

    Twenty percent of the world's forest is within 100 m of a forest edge, but much of our understanding of forest carbon (C) cycling comes from large, intact ecosystems, which creates an important mismatch between the landscapes we study and those we aim to characterize. The temperate broadleaf forest is the most heavily fragmented forest biome in the world and its growth and carbon storage responses to forest edge effects appear to be the opposite of those in the tropical and boreal regions. We used field measurements to quantify the drivers of temperate forest C cycling response to edge effects, characterizing vegetative growth, respiration, and forest structure. We find large gradients in air and soil temperature from the forest interior to edge (up to 4 and 10° C, respectively) and the magnitude of this gradient is inversely correlated to the size of the forest edge growth enhancement. Further, leaf area index increases with proximity to the forest edge. While we also find increases in soil respiration between the forest interior and edge, this flux is small relative to aboveground growth enhancement near the edge. These findings represent an important advancement in our understanding of forest C cycle response to edge effects and will greatly improve our capacity to constrain biogenic C fluxes in fragmented and heterogeneous landscapes.

  2. Pion double charge exchange

    International Nuclear Information System (INIS)

    Cooper, M.D.

    1978-01-01

    The pion double charge exchange data on the oxygen isotopes is reviewed and new data on 9 Be, 12 C, 24 Mg, and 28 Si are presented. Where theoretical calculations exist, they are compared to the data. 9 references

  3. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    2012-10-06

    Oct 6, 2012 ... Anyhow, the 'multi-isotope' ansatz is needed to compensate for matrix element ... The neccessary half-life requirement to touch this ... site energy depositions (like double beta decay) and multiple site interactions (most of.

  4. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Ehlers, Michael; Adland, Karoline Thorp

    activities carried out within the framework of the projects. The formal part of Project Half Double was initiated in June 2015. We started out by developing, refining and testing the Half Double methodology on seven pilot projects in the first phase of the project, which will end June 2016. The current......Project Half Double has a clear mission to succeed in finding a project methodology that can increase the success rate of our projects while increasing the speed at which we generate new ideas and develop new products and services. Chaos and complexity should be seen as a basic condition...... and as an opportunity rather than a threat and a risk. We are convinced that by doing so, we can strengthen Denmark’s competitiveness and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “projects in half the time with double the impact”, where projects in half the time...

  5. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Gerstrøm, Anna; Frederiksen, Signe Hedeboe

    The Half Double mission: Project Half Double has a clear mission. We want to succeed in finding a project methodology that can increase the success rate of our projects while increasing the development speed of new products and services. We are convinced that by doing so we can strengthen...... the competitiveness of Denmark and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “Projects in half the time with double the impact” where projects in half the time should be understood as half the time to impact (benefit realization, effect is achieved......) and not as half the time for project execution. The Half Double project journey: It all began in May 2013 when we asked ourselves: How do we create a new and radical project paradigm that can create successful projects? Today we are a movement of hundreds of passionate project people, and it grows larger...

  6. Double beta decay: experiments

    International Nuclear Information System (INIS)

    Fiorini, Ettore

    2006-01-01

    The results obtained so far and those of the running experiments on neutrinoless double beta decay are reviewed. The plans for second generation experiments, the techniques to be adopted and the expected sensitivities are compared and discussed

  7. A double layer review

    International Nuclear Information System (INIS)

    Block, L.P.

    1977-06-01

    A review of the main results on electrostatic double layers (sometimes called space charge layers or sheaths) obtained from theory, and laboratory and space experiments up to the spring of 1977 is given. By means of barium jets and satellite probes, double layers have now been found at the altitudes, earlier predicted theoretically. The general potential distribution above the auroral zone, suggested by inverted V-events and electric field reversals, is corroborated. (author)

  8. Edge Modeling by Two Blur Parameters in Varying Contrasts.

    Science.gov (United States)

    Seo, Suyoung

    2018-06-01

    This paper presents a method of modeling edge profiles with two blur parameters, and estimating and predicting those edge parameters with varying brightness combinations and camera-to-object distances (COD). First, the validity of the edge model is proven mathematically. Then, it is proven experimentally with edges from a set of images captured for specifically designed target sheets and with edges from natural images. Estimation of the two blur parameters for each observed edge profile is performed with a brute-force method to find parameters that produce global minimum errors. Then, using the estimated blur parameters, actual blur parameters of edges with arbitrary brightness combinations are predicted using a surface interpolation method (i.e., kriging). The predicted surfaces show that the two blur parameters of the proposed edge model depend on both dark-side edge brightness and light-side edge brightness following a certain global trend. This is similar across varying CODs. The proposed edge model is compared with a one-blur parameter edge model using experiments of the root mean squared error for fitting the edge models to each observed edge profile. The comparison results suggest that the proposed edge model has superiority over the one-blur parameter edge model in most cases where edges have varying brightness combinations.

  9. Power spectrum weighted edge analysis for straight edge detection in images

    Science.gov (United States)

    Karvir, Hrishikesh V.; Skipper, Julie A.

    2007-04-01

    Most man-made objects provide characteristic straight line edges and, therefore, edge extraction is a commonly used target detection tool. However, noisy images often yield broken edges that lead to missed detections, and extraneous edges that may contribute to false target detections. We present a sliding-block approach for target detection using weighted power spectral analysis. In general, straight line edges appearing at a given frequency are represented as a peak in the Fourier domain at a radius corresponding to that frequency, and a direction corresponding to the orientation of the edges in the spatial domain. Knowing the edge width and spacing between the edges, a band-pass filter is designed to extract the Fourier peaks corresponding to the target edges and suppress image noise. These peaks are then detected by amplitude thresholding. The frequency band width and the subsequent spatial filter mask size are variable parameters to facilitate detection of target objects of different sizes under known imaging geometries. Many military objects, such as trucks, tanks and missile launchers, produce definite signatures with parallel lines and the algorithm proves to be ideal for detecting such objects. Moreover, shadow-casting objects generally provide sharp edges and are readily detected. The block operation procedure offers advantages of significant reduction in noise influence, improved edge detection, faster processing speed and versatility to detect diverse objects of different sizes in the image. With Scud missile launcher replicas as target objects, the method has been successfully tested on terrain board test images under different backgrounds, illumination and imaging geometries with cameras of differing spatial resolution and bit-depth.

  10. Edge strength of CAD/CAM materials.

    Science.gov (United States)

    Pfeilschifter, Maria; Preis, Verena; Behr, Michael; Rosentritt, Martin

    2018-05-16

    To investigate the edge force of CAD/CAM materials as a function of (a) material, (b) thickness, and (c) distance from the margin. Materials intended for processing with CAD/CAM were investigated: eight resin composites, one resin-infiltrated ceramic, and a clinically proven lithiumdisilicate ceramic (reference). To measure edge force (that is, load to failure/crack), plates (d = 1 mm) were fixed and loaded with a Vickers diamond indenter (1 mm/min, Zwick 1446) at a distance of 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 1.0 mm from the edge. Edge force was defined as a loading force at a distance of 0.5 mm. The type of failure was determined. To investigate the influence of the thickness, all data were determined on 1-mm and 2-mm plates. To test the influence of bonding and an underlying dentin, individual 1-mm plates were bonded to a 1-mm-thick dentin-like (concerning modulus of elasticity) resin composite. For the 1-mm plates, edge force varied between 64.4 ± 24.2 N (Shofu Block HC) and 183.2 ± 63.3 N (ceramic reference), with significant (p ≤ 0.001) differences between the materials. For the 2-mm plates, values between 129.2 ± 32.5 N (Lava Ultimate) and 230.3 ± 67.5 N (Cerasmart) were found. Statistical comparison revealed no significant differences (p > 0.109) between the materials. Brilliant Crios (p = 0.023), Enamic (p = 0.000), Shofu Blocks HC (p = 0.009), and Grandio Bloc (p = 0.002) showed significantly different edge force between the 1-mm- and 2-mm-thick plates. The failure pattern was either cracking, (severe) chipping, or fracture. Material, material thickness, and distance from the edge impact the edge force of CAD/CAM materials. CAD/CAM materials should be carefully selected on the basis of their individual edge force and performance during milling. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. Acyclicity in edge-colored graphs

    DEFF Research Database (Denmark)

    Gutin, Gregory; Jones, Mark; Sheng, Bin

    2017-01-01

    A walk W in edge-colored graphs is called properly colored (PC) if every pair of consecutive edges in W is of different color. We introduce and study five types of PC acyclicity in edge-colored graphs such that graphs of PC acyclicity of type i is a proper superset of graphs of acyclicity of type i......+1, i=1,2,3,4. The first three types are equivalent to the absence of PC cycles, PC closed trails, and PC closed walks, respectively. While graphs of types 1, 2 and 3 can be recognized in polynomial time, the problem of recognizing graphs of type 4 is, somewhat surprisingly, NP-hard even for 2-edge-colored...... graphs (i.e., when only two colors are used). The same problem with respect to type 5 is polynomial-time solvable for all edge-colored graphs. Using the five types, we investigate the border between intractability and tractability for the problems of finding the maximum number of internally vertex...

  12. Changes in Soil Available Phosphorus, Leaf Phosphorus Content and Yield of Sword Bean (Canavalia ensiformis (L. DC. by Application of SP-36 and Phosphate Rock on Acid Upland Soil of East Lampung

    Directory of Open Access Journals (Sweden)

    Achmad Arivin Rivaie

    2015-01-01

    Full Text Available A glasshouse trial was performed to determine changes in phosphorus (P nutrition and the yield of sword bean (Canavalia ensiformis (L. DC. following the application of different rates and types of P fertilizer in an acid upland soil of East Lampung. Two different types of P fertilizer, namely SP-36 (total P = 36% and Phosphate Rock (PR (total P = 24.3%, particle size distribution = 75% <0.25 mm, 85% < 0.50 mm, 90% < 1.00 mm were used in the trial. For the treatment, each P fertilizer type consisted of four rates (0, 50, 100 and 150 mg P2O5 kg-1 soil that were arranged in a Completely Randomized Design with four replications. The results showed that the application of P fertilizers had significant effects on soil pH, soil plant-available P, the potential-P (HCl 25%, leaf N and P concentrations, the yield of sword bean. Increased rates of both forms of P fertilizer increased the soil pH values. As the soil used had low pH and very high exchangeable Al, hence, this result is most probably related to the addition of Ca2+ to the soil solution that resulted from the P fertiliser applied (liming effect, either from SP-36 (monocalcium phosphate or PR (flour apatite. There was no difference in soil available P concentration due to the different in P fertilizer types, indicating that 4 months after the fertilizer application, the relatively insoluble Phosphate Rock had the same P solubility with SP-36. Increased rates of both forms of P fertilizer increased the sword bean yield. For the application of 0 kg P2O5 ha-1, although sword bean crops had pods, but, they did not give any seed. Whereas, at the addition of P fertilizer at the rate of 50, 100, and 150 kg P2O5 ha-1 for both P fertilizer types, the crops were able to give the seeds in the pods.

  13. Changes in Soil Available Phosphorus, Leaf Phosphorus Content and Yield of Sword Bean (Canavalia Ensiformis (L.) DC.) by Application of SP-36 and Phosphate Rock on Acid Upland Soil of East Lampung

    OpenAIRE

    Achmad Arivin Rivaie

    2015-01-01

    A glasshouse trial was performed to determine changes in phosphorus (P) nutrition and the yield of sword bean (Canavalia ensiformis (L.) DC.) following the application of different rates and types of P fertilizer in an acid upland soil of East Lampung. Two different types of P fertilizer, namely SP-36 (total P = 36%) and Phosphate Rock (PR) (total P = 24.3%, particle size distribution = 75% <0.25 mm, 85% < 0.50 mm, 90% < 1.00 mm) were used in the trial. For the treatment, each P fert...

  14. Infective endocarditis following transcatheter edge-to-edge mitral valve repair: A systematic review.

    Science.gov (United States)

    Asmarats, Lluis; Rodriguez-Gabella, Tania; Chamandi, Chekrallah; Bernier, Mathieu; Beaudoin, Jonathan; O'Connor, Kim; Dumont, Eric; Dagenais, François; Paradis, Jean-Michel; Rodés-Cabau, Josep

    2018-05-10

    To assess the clinical characteristics, management, and outcomes of patients diagnosed with infective endocarditis (IE) after edge-to-edge mitral valve repair with the MitraClip device. Transcatheter edge-to-edge mitral valve repair has emerged as an alternative to surgery in high-risk patients. However, few data exist on IE following transcatheter mitral procedures. Four electronic databases (PubMed, Google Scholar, Embase, and Cochrane Library) were searched for original published studies on IE after edge-to-edge transcatheter mitral valve repair from 2003 to 2017. A total of 10 publications describing 12 patients with definitive IE (median age 76 years, 55% men) were found. The mean logistic EuroSCORE/EuroSCORE II were 41% and 45%, respectively. The IE episode occurred early (within 12 months post-procedure) in nine patients (75%; within the first month in five patients). Staphylococcus aureus was the most frequent (60%) causal microorganism, and severe mitral regurgitation was present in all cases but one. Surgical mitral valve replacement (SMVR) was performed in most (67%) patients, and the mortality associated with the IE episode was high (42%). IE following transcatheter edge-to-edge mitral valve repair is a rare but life-threatening complication, usually necessitating SMVR despite the high-risk profile of the patients. These results highlight the importance of adequate preventive measures and a prompt diagnosis and treatment of this serious complication. © 2018 Wiley Periodicals, Inc.

  15. Size effect model for the edge strength of glass with cut and ground edge finishing

    NARCIS (Netherlands)

    Vandebroek, M.; Louter, C.; Caspeele, R.; Ensslen, F.; Belis, J.L.I.F.

    2014-01-01

    The edge strength of glass is influenced by the size of the surface (near the edge) which is subjected to tensile stresses. To quantify this size effect, 8 series of single layer annealed glass beam specimens (as-received glass) were subjected to in-plane four-point bending with linearly increased

  16. Edge printability: techniques used to evaluate and improve extreme wafer edge printability

    Science.gov (United States)

    Roberts, Bill; Demmert, Cort; Jekauc, Igor; Tiffany, Jason P.

    2004-05-01

    The economics of semiconductor manufacturing have forced process engineers to develop techniques to increase wafer yield. Improvements in process controls and uniformities in all areas of the fab have reduced film thickness variations at the very edge of the wafer surface. This improved uniformity has provided the opportunity to consider decreasing edge exclusions, and now the outermost extents of the wafer must be considered in the yield model and expectations. These changes have increased the requirements on lithography to improve wafer edge printability in areas that previously were not even coated. This has taxed all software and hardware components used in defining the optical focal plane at the wafer edge. We have explored techniques to determine the capabilities of extreme wafer edge printability and the components of the systems that influence this printability. We will present current capabilities and new detection techniques and the influence that the individual hardware and software components have on edge printability. We will show effects of focus sensor designs, wafer layout, utilization of dummy edge fields, the use of non-zero overlay targets and chemical/optical edge bead optimization.

  17. Topological edge modes in multilayer graphene systems

    KAUST Repository

    Ge, Lixin

    2015-08-10

    Plasmons can be supported on graphene sheets as the Dirac electrons oscillate collectively. A tight-binding model for graphene plasmons is a good description as the field confinement in the normal direction is strong. With this model, the topological properties of plasmonic bands in multilayer graphene systems are investigated. The Zak phases of periodic graphene sheet arrays are obtained for different configurations. Analogous to Su-Schrieffer-Heeger (SSH) model in electronic systems, topological edge plasmon modes emerge when two periodic graphene sheet arrays with different Zak phases are connected. Interestingly, the dispersion of these topological edge modes is the same as that in the monolayer graphene and is invariant as the geometric parameters of the structure such as the separation and period change. These plasmonic edge states in multilayer graphene systems can be further tuned by electrical gating or chemical doping. © 2015 Optical Society of America.

  18. Performance of active edge pixel sensors

    Science.gov (United States)

    Bomben, M.; Ducourthial, A.; Bagolini, A.; Boscardin, M.; Bosisio, L.; Calderini, G.; D'Eramo, L.; Giacomini, G.; Marchiori, G.; Zorzi, N.; Rummler, A.; Weingarten, J.

    2017-05-01

    To cope with the High Luminosity LHC harsh conditions, the ATLAS inner tracker has to be upgraded to meet requirements in terms of radiation hardness, pile up and geometrical acceptance. The active edge technology allows to reduce the insensitive area at the border of the sensor thanks to an ion etched trench which avoids the crystal damage produced by the standard mechanical dicing process. Thin planar n-on-p pixel sensors with active edge have been designed and produced by LPNHE and FBK foundry. Two detector module prototypes, consisting of pixel sensors connected to FE-I4B readout chips, have been tested with beams at CERN and DESY. In this paper the performance of these modules are reported. In particular the lateral extension of the detection volume, beyond the pixel region, is investigated and the results show high hit efficiency also at the detector edge, even in presence of guard rings.

  19. Floquet edge states in germanene nanoribbons

    KAUST Repository

    Tahir, Muhammad

    2016-08-23

    We theoretically demonstrate versatile electronic properties of germanene monolayers under circularly, linearly, and elliptically polarized light. We show for the high frequency regime that the edge states can be controlled by tuning the amplitude of the light and by applying a static electric field. For circularly polarized light the band gap in one valley is reduced and in the other enhanced, enabling single valley edge states. For linearly polarized light spin-split states are found for both valleys, being connected by time reversal symmetry. The effects of elliptically polarized light are similar to those of circularly polarized light. The transport properties of zigzag nanoribbons in the presence of disorder confirm a nontrivial nature of the edge states under circularly and elliptically polarized light.

  20. Controllable edge feature sharpening for dental applications.

    Science.gov (United States)

    Fan, Ran; Jin, Xiaogang

    2014-01-01

    This paper presents a new approach to sharpen blurred edge features in scanned tooth preparation surfaces generated by structured-light scanners. It aims to efficiently enhance the edge features so that the embedded feature lines can be easily identified in dental CAD systems, and to avoid unnatural oversharpening geometry. We first separate the feature regions using graph-cut segmentation, which does not require a user-defined threshold. Then, we filter the face normal vectors to propagate the geometry from the smooth region to the feature region. In order to control the degree of the sharpness, we propose a feature distance measure which is based on normal tensor voting. Finally, the vertex positions are updated according to the modified face normal vectors. We have applied the approach to scanned tooth preparation models. The results show that the blurred edge features are enhanced without unnatural oversharpening geometry.

  1. Controllable Edge Feature Sharpening for Dental Applications

    Directory of Open Access Journals (Sweden)

    Ran Fan

    2014-01-01

    Full Text Available This paper presents a new approach to sharpen blurred edge features in scanned tooth preparation surfaces generated by structured-light scanners. It aims to efficiently enhance the edge features so that the embedded feature lines can be easily identified in dental CAD systems, and to avoid unnatural oversharpening geometry. We first separate the feature regions using graph-cut segmentation, which does not require a user-defined threshold. Then, we filter the face normal vectors to propagate the geometry from the smooth region to the feature region. In order to control the degree of the sharpness, we propose a feature distance measure which is based on normal tensor voting. Finally, the vertex positions are updated according to the modified face normal vectors. We have applied the approach to scanned tooth preparation models. The results show that the blurred edge features are enhanced without unnatural oversharpening geometry.

  2. Edge database analysis for extrapolation to ITER

    International Nuclear Information System (INIS)

    Shimada, M.; Janeschitz, G.; Stambaugh, R.D.

    1999-01-01

    An edge database has been archived to facilitate cross-machine comparisons of SOL and edge pedestal characteristics, and to enable comparison with theoretical models with an aim to extrapolate to ITER. The SOL decay lengths of power, density and temperature become broader for increasing density and q 95 . The power decay length is predicted to be 1.4-3.5 cm (L-mode) and 1.4-2.7 cm (H-mode) at the midplane in ITER. Analysis of Type I ELMs suggests that each giant ELM on ITER would exceed the ablation threshold of the divertor plates. Theoretical models are proposed for the H-mode transition, for Type I and Type III ELMs and are compared with the edge pedestal database. (author)

  3. Long coherence times for edge spins

    Science.gov (United States)

    Kemp, Jack; Yao, Norman Y.; Laumann, Christopher R.; Fendley, Paul

    2017-06-01

    We show that in certain one-dimensional spin chains with open boundary conditions, the edge spins retain memory of their initial state for very long times, even at infinite temperature. The long coherence times do not require disorder, only an ordered phase. In the integrable Ising and XYZ chains, the presence of a strong zero mode means the coherence time is infinite. When Ising is perturbed by interactions breaking the integrability, the coherence time remains exponentially long in the perturbing couplings. We show that this is a consequence of an edge ‘almost’ strong zero mode that almost commutes with the Hamiltonian. We compute this operator explicitly, allowing us to estimate accurately the plateau value of edge spin autocorrelator.

  4. Preparation of edge states by shaking boundaries

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Z.C. [Department of Physics, Fuzhou University, Fuzhou 350002 (China); Center for Quantum Sciences and School of Physics, Northeast Normal University, Changchun 130024 (China); Hou, S.C. [Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan (China); Wang, L.C. [School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116024 (China); Yi, X.X., E-mail: yixx@nenu.edu.cn [Center for Quantum Sciences and School of Physics, Northeast Normal University, Changchun 130024 (China)

    2016-10-15

    Preparing topological states of quantum matter, such as edge states, is one of the most important directions in condensed matter physics. In this work, we present a proposal to prepare edge states in Aubry–André–Harper (AAH) model with open boundaries, which takes advantage of Lyapunov control to design operations. We show that edge states can be obtained with almost arbitrary initial states. A numerical optimalization for the control is performed and the dependence of control process on the system size is discussed. The merit of this proposal is that the shaking exerts only on the boundaries of the model. As a by-product, a topological entangled state is achieved by elaborately designing the shaking scheme.

  5. Evolution of Edge Pedestal Profiles Between ELMs

    Science.gov (United States)

    Floyd, J. P.; Stacey, W. M.; Groebner, R. J.

    2012-10-01

    The measured edge profile evolution in DIII-D discharges is analyzed in terms of the implied thermal diffusivities, ion diffusion coefficients and pinch velocities, using the momentum-balance methodology of Ref. [1], extended to take into account ion orbit loss and X-point loss. The evolution of the density, temperature, rotation and radial electric field profiles in the edge pedestal between edge localized modes (ELMs) provides information of these diffusive and non-diffusive transport processes in the pedestal of H-mode plasmas. This methodology is incorporated in the GTEDGE code developed for DIII-D data interpretation. Using a smaller integration time for the charge exchange recombination measurements than in Ref. [1] allows a more detailed examination of the time evolution of the ion temperature and rotation profiles. 6pt [1] W.M. Stacey and R.J. Groebner, Nucl. Fusion 51, 063024 (2011).

  6. Edge effects in composites by moire interferometry

    Science.gov (United States)

    Czarnek, R.; Post, D.; Herakovich, C.

    1983-01-01

    The very high sensitivity of moire interferometry has permitted the present edge effect experiments to be conducted at a low average stress and strain level, assuring linear and elastic behavior in the composite material samples tested. Sensitivity corresponding to 2450 line/mm moire was achieved with a 0.408 micron/fringe. Simultaneous observations of the specimen face and edge displacement fields showed good fringe definition despite the 1-mm thickness of the specimens and the high gradients, and it is noted that the use of a carrier pattern and optical filtering was effective in even these conditions. Edge effects and dramatic displacement gradients were confirmed in angle-ply composite laminates.

  7. Properties of the tokamak edge plasma

    International Nuclear Information System (INIS)

    Wolff, H.

    1988-01-01

    A short review of some features of the edge plasma in limiter tokamaks is given. The limits of the simple one-dimensional scrape-off layer (SOL) model and the relation between the core plasma are discussed. Multifaceted asymmetric radiation from the edge (MARFE) phenomena and detached plasma are closely connected with the particle and energy balance of the SOL. Their occurrence is based on the relation of plasma parameters of the edge plasma to those of the core. Important problems of plasma wall interactions are the detection of the impurity sources and sinks and the study of the impurity transport and shielding. The non-uniform character of plasma wall interactions and their dependence on the discharge performance still renders difficult any theoretical forecast of impurity distribution and transport and calls for better diagnostics. (author)

  8. Leading-edge vortex lifts swifts.

    Science.gov (United States)

    Videler, J J; Stamhuis, E J; Povel, G D E

    2004-12-10

    The current understanding of how birds fly must be revised, because birds use their hand-wings in an unconventional way to generate lift and drag. Physical models of a common swift wing in gliding posture with a 60 degrees sweep of the sharp hand-wing leading edge were tested in a water tunnel. Interactions with the flow were measured quantitatively with digital particle image velocimetry at Reynolds numbers realistic for the gliding flight of a swift between 3750 and 37,500. The results show that gliding swifts can generate stable leading-edge vortices at small (5 degrees to 10 degrees) angles of attack. We suggest that the flow around the arm-wings of most birds can remain conventionally attached, whereas the swept-back hand-wings generate lift with leading-edge vortices.

  9. Edge modulation of electronics and transport properties of cliff-edge phosphorene nanoribbons

    Science.gov (United States)

    Guo, Caixia; Wang, Tianxing; Xia, Congxin; Liu, Yufang

    2017-12-01

    Based on the first-principles calculations, we study the electronic structures and transport properties of cliff-like edge phosphorene nanoribbons (CPNRs), considering different types of edge passivation. The band structures of bare CPNRs possess the metallic features; while hydrogen (H), fluorine (F), chlorine (Cl) and oxygen (O) atoms-passivated CPNRs are semiconductor materials, and the band gap values monotonically decrease when the ribbon width increases. Moreover, the H and F-passivated CPNRs exhibit the direct band gap characteristics, while the Cl and O-passivated cases show the features of indirect band gap. In addition, the edge passivated CPNRs are more energetically stable than bare edge case. Meanwhile, our results also show that the transport properties of the CPNRs can be obviously influenced by the different edge passivation.

  10. Physics-based edge evaluation for improved color constancy

    NARCIS (Netherlands)

    Gijsenij, A.; Gevers, T.; van de Weijer, J.

    2009-01-01

    Edge-based color constancy makes use of image derivatives to estimate the illuminant. However, different edge types exist in real-world images such as shadow, geometry, material and highlight edges. These different edge types may have a distinctive influence on the performance of the illuminant

  11. Plasma edge modelling with ICRF coupling

    Directory of Open Access Journals (Sweden)

    Zhang Wei

    2017-01-01

    Full Text Available The physics of Radio-Frequency (RF wave heating in the Ion Cyclotron Range of Frequencies (ICRF in the core plasmas of fusion devices are relatively well understood while those in the Scrape-Off Layer (SOL remain still unresolved. This paper is dedicated to study the ICRF interactions with the plasma edge, mainly from the theoretical and numerical point of view, in particular with the 3D edge plasma fluid and neutral transport code EMC3-EIRENE and various wave codes. Here emphasis is given to the improvement of ICRF coupling with local gas puffing and to the ICRF induced density convection in the SOL.

  12. CO2 fluxes near a forest edge

    DEFF Research Database (Denmark)

    Sogachev, Andrey; Leclerc, Monique Y.; Zhang, Gensheng

    2008-01-01

    In contrast with recent advances on the dynamics of the flow at a forest edge, few studies have considered its role on scalar transport and, in particular, on CO2 transfer. The present study addresses the influence of the abrupt roughness change on forest atmosphere CO2 exchange and contrasts...... as a function of both sources/sinks distribution and the vertical structure of the canopy. Results suggest that the ground source plays a major role in the formation of wave-like vertical CO2 flux behavior downwind of a forest edge, despite the fact that the contribution of foliage sources/sinks changes...

  13. Edge detection techniques for iris recognition system

    International Nuclear Information System (INIS)

    Tania, U T; Motakabber, S M A; Ibrahimy, M I

    2013-01-01

    Nowadays security and authentication are the major parts of our daily life. Iris is one of the most reliable organ or part of human body which can be used for identification and authentication purpose. To develop an iris authentication algorithm for personal identification, this paper examines two edge detection techniques for iris recognition system. Between the Sobel and the Canny edge detection techniques, the experimental result shows that the Canny's technique has better ability to detect points in a digital image where image gray level changes even at slow rate

  14. Radiative edge layers in limiter tokamaks

    International Nuclear Information System (INIS)

    Monier-Garbet, P.

    1997-01-01

    The characteristics of the highly radiative edge layers produced in the limiter configuration and with an open ergodic divertor are reviewed, with emphasis on the results obtained in TEXTOR and Tore Supra. In these two experiments an impurity injection technique is used to obtain highly radiating homogeneous peripheral layers. This requires that the peripheral radiation capability be maximized, while at the same time avoiding plasma core contamination; it is also necessary to insure the stability of the radiating layer. These physics issues, governing the success of the highly radiative edge scenario, are discussed. (orig.)

  15. Wing Leading Edge Concepts for Noise Reduction

    Science.gov (United States)

    Shmilovich, Arvin; Yadlin, Yoram; Pitera, David M.

    2010-01-01

    This study focuses on the development of wing leading edge concepts for noise reduction during high-lift operations, without compromising landing stall speeds, stall characteristics or cruise performance. High-lift geometries, which can be obtained by conventional mechanical systems or morphing structures have been considered. A systematic aerodynamic analysis procedure was used to arrive at several promising configurations. The aerodynamic design of new wing leading edge shapes is obtained from a robust Computational Fluid Dynamics procedure. Acoustic benefits are qualitatively established through the evaluation of the computed flow fields.

  16. X-point effect on edge stability

    International Nuclear Information System (INIS)

    Saarelma, S; Kirk, A; Kwon, O J

    2011-01-01

    We study the effects of the X-point configuration on edge localized mode (ELM) triggering peeling and ballooning modes using fixed boundary equilibria and modifying the plasma shape to approach the limit of a true X-point. The current driven pure peeling modes are asymptotically stabilized by the X-point while the stabilizing effect on ballooning modes depends on the poloidal location of the X-point. The coupled peeling-ballooning modes experience the elimination of the peeling component as the X-point is introduced. This can significantly affect the edge stability diagrams used to analyse the ELM triggering mechanisms.

  17. Edge Cut Domination, Irredundance, and Independence in Graphs

    OpenAIRE

    Fenstermacher, Todd; Hedetniemi, Stephen; Laskar, Renu

    2016-01-01

    An edge dominating set $F$ of a graph $G=(V,E)$ is an \\textit{edge cut dominating set} if the subgraph $\\langle V,G-F \\rangle$ is disconnected. The \\textit{edge cut domination number} $\\gamma_{ct}(G)$ of $G$ is the minimum cardinality of an edge cut dominating set of $G.$ In this paper we study the edge cut domination number and investigate its relationships with other parameters of graphs. We also introduce the properties edge cut irredundance and edge cut independence.

  18. Properties of the edge plasma in the rebuilt Extrap-T2R reversed field pinch experiment

    International Nuclear Information System (INIS)

    Vianello, N; Spolaore, M; Serianni, G; Bergsaker, H; Antoni, V; Drake, J R

    2002-01-01

    The edge region of the rebuilt Extrap-T2R reversed field pinch experiment has been investigated using Langmuir probes. Radial profiles of main plasma parameters are obtained and compared with those of the previous device Extrap-T2. The spontaneous setting up of a double shear layer of ExB toroidal velocity is confirmed. The particle flux induced by electrostatic fluctuations is calculated and the resulting effective diffusion coefficient is consistent with the Bohm estimate. A close relationship between electrostatic fluctuations at the edge and non-linear coupling of MHD modes in the core is found

  19. Properties of the edge plasma in the rebuilt Extrap-T2R reversed field pinch experiment

    Science.gov (United States)

    Vianello, N.; Spolaore, M.; Serianni, G.; Bergsåker, H.; Antoni, V.; Drake, J. R.

    2002-12-01

    The edge region of the rebuilt Extrap-T2R reversed field pinch experiment has been investigated using Langmuir probes. Radial profiles of main plasma parameters are obtained and compared with those of the previous device Extrap-T2. The spontaneous setting up of a double shear layer of E×B toroidal velocity is confirmed. The particle flux induced by electrostatic fluctuations is calculated and the resulting effective diffusion coefficient is consistent with the Bohm estimate. A close relationship between electrostatic fluctuations at the edge and non-linear coupling of MHD modes in the core is found.

  20. Aristotle and Double Effect

    DEFF Research Database (Denmark)

    Di Nucci, Ezio

    2014-01-01

    There are some interesting similarities between Aristotle’s ‘mixed actions’ in Book III of the Nicomachean Ethics and the actions often thought to be justifiable with the Doctrine of Double Effect. Here I analyse these similarities by comparing Aristotle’s examples of mixed actions with standard...... cases from the literature on double effect such as, amongst others, strategic bombing, the trolley problem, and craniotomy. I find that, despite some common features such as the dilemmatic structure and the inevitability of a bad effect, Aristotle’s mixed actions do not count as cases justifiable...... through application of the Doctrine of Double Effect because they fail to meet the crucial necessary condition of the Doctrine according to which the bad effect can only be a merely foreseen side- effect and not an intended means....

  1. Coulomb double helical structure

    Science.gov (United States)

    Kamimura, Tetsuo; Ishihara, Osamu

    2012-01-01

    Structures of Coulomb clusters formed by dust particles in a plasma are studied by numerical simulation. Our study reveals the presence of various types of self-organized structures of a cluster confined in a prolate spheroidal electrostatic potential. The stable configurations depend on a prolateness parameter for the confining potential as well as on the number of dust particles in a cluster. One-dimensional string, two-dimensional zigzag structure and three-dimensional double helical structure are found as a result of the transition controlled by the prolateness parameter. The formation of stable double helical structures resulted from the transition associated with the instability of angular perturbations on double strings. Analytical perturbation study supports the findings of numerical simulations.

  2. Fracture toughness of zirconia ceramic crowns made by feather-edge tooth preparation design

    Directory of Open Access Journals (Sweden)

    Mirković Nemanja

    2012-01-01

    Full Text Available Background/Aim. Fracture toughness determines functional crown strenght and prevents damages on ceramics during mastication. There is a lack of relevant literature data about fracture toughness of crowns made by feather-edge preparation. Mechanical testing of ceramic samples is supposed to show if feather-edge tooth preparation is a successful method for making ceramic crowns without any risk of reduction of their mechanical properties. This research was done to establish effects of feather-edge tooth preparation on fracture toughness of single zirconia ceramic crowns. Methods. The research was performed as an experimental study. Sixty (60 ceramic crowns were made on non-carious extracted human premolars. Thirty (30 crowns were made on the basis of feather-edge preparation (experimental group I. The group II included 30 crowns made on 1 mm rounded shoulder. Crowns fabrication was executed on a copy mill production system “Zirkonzahn” (Zirkonzahn GMBH, Gais, Germany. The spherical compression test was used to determine fracture toughness, using 6 mm diameter ceramic ball. Fracture load for damaging ceramic crown was recorded on a universal testing machine - Zwick, type 1464, with the speed of 0.05 mm/min. Results. The results of this research introduced significant differences between fracture toughness of ceramic samples in every examined group. However, fracture toughness of crowns from both group was above 2 000 N, what was double beyond a recommended value. The mean value of fracture toughness in the feather-edge group was 2 090 N, and in shoulder group it was 2 214 N. Conclusion. This research showed a high fracture toughness of zirconia crowns made on feather-edge preparation. The examined crowns showed a fracture resistance at a sufficient distance in relation to the minimum values of functional loads. Further research of functional loads of these crown is necessary, as well as research of marginal adaptation of cemented crowns and

  3. Optically Unraveling the Edge Chirality-Dependent Band Structure and Plasmon Damping in Graphene Edges.

    Science.gov (United States)

    Duan, Jiahua; Chen, Runkun; Cheng, Yuan; Yang, Tianzhong; Zhai, Feng; Dai, Qing; Chen, Jianing

    2018-05-01

    The nontrivial topological origin and pseudospinorial character of electron wavefunctions make edge states possess unusual electronic properties. Twenty years ago, the tight-binding model calculation predicted that zigzag termination of 2D sheets of carbon atoms have peculiar edge states, which show potential application in spintronics and modern information technologies. Although scanning probe microscopy is employed to capture this phenomenon, the experimental demonstration of its optical response remains challenging. Here, the propagating graphene plasmon provides an edge-selective polaritonic probe to directly detect and control the electronic edge state at ambient condition. Compared with armchair, the edge-band structure in the bandgap gives rise to additional optical absorption and strongly absorbed rim at zigzag edge. Furthermore, the optical conductivity is reconstructed and the anisotropic plasmon damping in graphene systems is revealed. The reported approach paves the way for detecting edge-specific phenomena in other van der Waals materials and topological insulators. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Tangential 2-D Edge Imaging for GPI and Edge/Impurity Modeling

    International Nuclear Information System (INIS)

    Maqueda, Ricardo; Levinton, Fred M.

    2011-01-01

    Nova Photonics, Inc. has a collaborative effort at the National Spherical Torus Experiment (NSTX). This collaboration, based on fast imaging of visible phenomena, has provided key insights on edge turbulence, intermittency, and edge phenomena such as edge localized modes (ELMs) and multi-faceted axisymmetric radiation from the edge (MARFE). Studies have been performed in all these areas. The edge turbulence/intermittency studies make use of the Gas Puff Imaging diagnostic developed by the Principal Investigator (Ricardo Maqueda) together with colleagues from PPPL. This effort is part of the International Tokamak Physics Activity (ITPA) edge, scrape-off layer and divertor group joint activity (DSOL-15: Inter-machine comparison of blob characteristics). The edge turbulence/blob study has been extended from the current location near the midplane of the device to the lower divertor region of NSTX. The goal of this effort was to study turbulence born blobs in the vicinity of the X-point region and their circuit closure on divertor sheaths or high density regions in the divertor. In the area of ELMs and MARFEs we have studied and characterized the mode structure and evolution of the ELM types observed in NSTX, as well as the study of the observed interaction between MARFEs and ELMs. This interaction could have substantial implications for future devices where radiative divertor regions are required to maintain detachment from the divertor plasma facing components.

  5. Edge control in CNC polishing, paper 2: simulation and validation of tool influence functions on edges.

    Science.gov (United States)

    Li, Hongyu; Walker, David; Yu, Guoyu; Sayle, Andrew; Messelink, Wilhelmus; Evans, Rob; Beaucamp, Anthony

    2013-01-14

    Edge mis-figure is regarded as one of the most difficult technical issues for manufacturing the segments of extremely large telescopes, which can dominate key aspects of performance. A novel edge-control technique has been developed, based on 'Precessions' polishing technique and for which accurate and stable edge tool influence functions (TIFs) are crucial. In the first paper in this series [D. Walker Opt. Express 20, 19787-19798 (2012)], multiple parameters were experimentally optimized using an extended set of experiments. The first purpose of this new work is to 'short circuit' this procedure through modeling. This also gives the prospect of optimizing local (as distinct from global) polishing for edge mis-figure, now under separate development. This paper presents a model that can predict edge TIFs based on surface-speed profiles and pressure distributions over the polishing spot at the edge of the part, the latter calculated by finite element analysis and verified by direct force measurement. This paper also presents a hybrid-measurement method for edge TIFs to verify the simulation results. Experimental and simulation results show good agreement.

  6. Edge currents in frustrated Josephson junction ladders

    Science.gov (United States)

    Marques, A. M.; Santos, F. D. R.; Dias, R. G.

    2016-09-01

    We present a numerical study of quasi-1D frustrated Josephson junction ladders with diagonal couplings and open boundary conditions, in the large capacitance limit. We derive a correspondence between the energy of this Josephson junction ladder and the expectation value of the Hamiltonian of an analogous tight-binding model, and show how the overall superconducting state of the chain is equivalent to the minimum energy state of the tight-binding model in the subspace of one-particle states with uniform density. To satisfy the constraint of uniform density, the superconducting state of the ladder is written as a linear combination of the allowed k-states of the tight-binding model with open boundaries. Above a critical value of the parameter t (ratio between the intra-rung and inter-rung Josephson couplings) the ladder spontaneously develops currents at the edges, which spread to the bulk as t is increased until complete coverage is reached. Above a certain value of t, which varies with ladder size (t = 1 for an infinite-sized ladder), the edge currents are destroyed. The value t = 1 corresponds, in the tight-binding model, to the opening of a gap between two bands. We argue that the disappearance of the edge currents with this gap opening is not coincidental, and that this points to a topological origin for these edge current states.

  7. Superconducting Metallic Glass Transition-Edge-Sensors

    Science.gov (United States)

    Hays, Charles C. (Inventor)

    2013-01-01

    A superconducting metallic glass transition-edge sensor (MGTES) and a method for fabricating the MGTES are provided. A single-layer superconducting amorphous metal alloy is deposited on a substrate. The single-layer superconducting amorphous metal alloy is an absorber for the MGTES and is electrically connected to a circuit configured for readout and biasing to sense electromagnetic radiation.

  8. Edge maps: Representing flow with bounded error

    KAUST Repository

    Bhatia, Harsh

    2011-03-01

    Robust analysis of vector fields has been established as an important tool for deriving insights from the complex systems these fields model. Many analysis techniques rely on computing streamlines, a task often hampered by numerical instabilities. Approaches that ignore the resulting errors can lead to inconsistencies that may produce unreliable visualizations and ultimately prevent in-depth analysis. We propose a new representation for vector fields on surfaces that replaces numerical integration through triangles with linear maps defined on its boundary. This representation, called edge maps, is equivalent to computing all possible streamlines at a user defined error threshold. In spite of this error, all the streamlines computed using edge maps will be pairwise disjoint. Furthermore, our representation stores the error explicitly, and thus can be used to produce more informative visualizations. Given a piecewise-linear interpolated vector field, a recent result [15] shows that there are only 23 possible map classes for a triangle, permitting a concise description of flow behaviors. This work describes the details of computing edge maps, provides techniques to quantify and refine edge map error, and gives qualitative and visual comparisons to more traditional techniques. © 2011 IEEE.

  9. Nonlinear neoclassical transport in toroidal edge plasmas

    International Nuclear Information System (INIS)

    Fueloep, T.

    2002-01-01

    Edge plasma processes play a critical role for the global confinement of the plasma in a tokamak. In the edge region, where impurity ions are abundant and the temperature and density gradients are large, the assumptions of standard neoclassical theory break down. This paper reviews recent extensions of neoclassical theory to treat this problem, in particular our own work, which focuses on the nonlinear aspects of transport in a plasma with heavy impurity ions. In this theory, the pressure and temperature gradients are allowed to be steeper than in conventional theory neoclassical theory, so that the friction force between the bulk ions and heavy impurities is comparable to the parallel impurity pressure gradient. The impurity ions are then found to undergo a spontaneous rearrangement on each flux surface. This reduces their parallel friction with the bulk ions and causes the neoclassical ion flux to become a non-monotonic function of the gradients for plasma parameters typical of the tokamak edge. Thus, the neoclassical confinement is improved in regions where the gradients are large, such as in the edge pedestal. (orig.)

  10. Nonlinear neoclassical theory for toroidal edge plasmas

    International Nuclear Information System (INIS)

    Fueloep, T.; Helander, P.

    2001-01-01

    Edge plasma processes play a critical role for the global confinement of the plasma. In the edge region, where impurity ions are abundant and the temperature and density gradients are large, the assumptions of the standard neoclassical theory break down. We have extended the theory of neoclassical transport in an impure plasma with arbitrary cross section and aspect ratio to allow for steeper pressure and temperature gradients than are usually considered in the conventional theory. The gradients are allowed to be so large that the friction force between the bulk ions and heavy impurities is comparable to the parallel impurity pressure gradient. In this case the impurity ions are found to undergo a spontaneous rearrangement on each flux surface. This reduces their parallel friction with the bulk ions and causes the neoclassical ion flux to become a non-monotonic function of the gradients for plasma parameters typical of the tokamak edge. Thus, the neoclassical confinement is improved in regions where the gradients are large, such as in the edge pedestal. The theoretical predictions are compared with experimental data from several tokamaks. (orig.)

  11. The SKED: speckle knife edge detector

    International Nuclear Information System (INIS)

    Sharpies, S D; Light, R A; Achamfuo-Yeboah, S O; Clark, M; Somekh, M G

    2014-01-01

    The knife edge detector—also known as optical beam deflection—is a simple and robust method of detecting ultrasonic waves using a laser. It is particularly suitable for detection of high frequency surface acoustic waves as the response is proportional to variation of the local tilt of the surface. In the case of a specular reflection of the incident laser beam from a smooth surface, any lateral movement of the reflected beam caused by the ultrasonic waves is easily detected by a pair of photodiodes. The major disadvantage of the knife edge detector is that it does not cope well with optically rough surfaces, those that give a speckled reflection. The optical speckles from a rough surface adversely affect the efficiency of the knife edge detector, because 'dark' speckles move synchronously with 'bright' speckles, and their contributions to the ultrasonic signal cancel each other out. We have developed a new self-adapting sensor which can cope with the optical speckles reflected from a rough surface. It is inelegantly called the SKED—speckle knife edge detector—and like its smooth surface namesake it is simple, cheap, compact, and robust. We describe the theory of its operation, and present preliminary experimental results validating the overall concept and the operation of the prototype device

  12. The SKED: speckle knife edge detector

    Science.gov (United States)

    Sharpies, S. D.; Light, R. A.; Achamfuo-Yeboah, S. O.; Clark, M.; Somekh, M. G.

    2014-06-01

    The knife edge detector—also known as optical beam deflection—is a simple and robust method of detecting ultrasonic waves using a laser. It is particularly suitable for detection of high frequency surface acoustic waves as the response is proportional to variation of the local tilt of the surface. In the case of a specular reflection of the incident laser beam from a smooth surface, any lateral movement of the reflected beam caused by the ultrasonic waves is easily detected by a pair of photodiodes. The major disadvantage of the knife edge detector is that it does not cope well with optically rough surfaces, those that give a speckled reflection. The optical speckles from a rough surface adversely affect the efficiency of the knife edge detector, because 'dark' speckles move synchronously with 'bright' speckles, and their contributions to the ultrasonic signal cancel each other out. We have developed a new self-adapting sensor which can cope with the optical speckles reflected from a rough surface. It is inelegantly called the SKED—speckle knife edge detector—and like its smooth surface namesake it is simple, cheap, compact, and robust. We describe the theory of its operation, and present preliminary experimental results validating the overall concept and the operation of the prototype device.

  13. Anomalous transport in the tokamak edge

    International Nuclear Information System (INIS)

    Vayakis, G.

    1991-04-01

    The tokamak edge has been studied with arrays of Langmuir and magnetic probes on the DITE and COMPASS-C devices. Measurements of plasma parameters such as density, temperature and radial magnetic field were taken in order to elucidate the character, effect on transport and origin of edge fluctuations. The tokamak edge is a strongly-turbulent environment, with large electrostatic fluctuation levels and broad spectra. The observations, including direct correlation measurements, are consistent with a picture in which the observed magnetic field fluctuations are driven by the perturbations in electrostatic parameters. The propagation characteristics of the turbulence, investigated using digital spectral techniques, appear to be dominated by the variation of the radial electric field, both in limiter and divertor plasmas. A shear layer is formed, associated in each case with the last closed flux surface. In the shear layer, the electrostatic wavenumber spectra are significantly broader. The predictions of a drift wave model (DDGDT) and of a family of models evolving from the rippling mode (RGDT group), are compared with experimental results. RGDT, augmented by impurity radiation effects, is shown to be the most reasonable candidate to explain the nature of the edge turbulence, only failing in its estimate of the wavenumber range. (Author)

  14. Edge Sheared Flows and Blob Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Myra, J.; D' Ippolito, D.; Russell, D., E-mail: jrmyra@lodestar.com [Lodestar Research Corporation, Boulder (United States); Davis, W. M.; Zweben, S. [Princeton Plasma Physics Laboratory, Princeton (United States); Terry, J.; LaBombard, B. [Massachusetts Institute of Technology, Cambridge (United States)

    2012-09-15

    Full text: A study of sheared flows in the edge and scrape-off layer (SOL) and their interaction with blob-filaments is presented. Edge sheared flows are believed to be important for the L-H, and H-L transitions. Blob generation and dynamics impacts both the (near-separatrix) scrape-off-layer (SOL) width critical for power handling in the divertor, and the interaction of plasma in the far SOL with plasma-facing components. These topics are critical for ITER and future devices. A fluid-based 2D curvature-interchange model embedded in the SOLT code is employed to study these issues. Sheared binormal flows both regulate the power flux crossing the separatrix and control the character of emitted turbulence structures such as blob-filaments. At a critical power level (depending on parameters) the laminar flows containing intermittent, but bound, structures give way to full-blown blob emissions signifying a transition from quasi-diffusive to convective transport. In order to diagnose sheared flows in experiments and assess their interaction with blobs, a blob-tracking algorithm has been developed and applied to both NSTX and Alcator C-Mod data. Blob motion and ellipticity can be affected by sheared flows, and are diagnosed and compared with seeded blob simulations. A picture of the interaction of blobs and sheared flows is emerging from advances in the theory and simulation of edge turbulence, combined with ever-improving capabilities for edge diagnostics and their analysis. (author)

  15. Edge Delamination of Monolayer Transition Metal Dichalcogenides.

    Science.gov (United States)

    Ly, Thuc Hue; Yun, Seok Joon; Thi, Quoc Huy; Zhao, Jiong

    2017-07-25

    Delamination of thin films from the supportive substrates is a critical issue within the thin film industry. The emergent two-dimensional, atomic layered materials, including transition metal dichalcogenides, are highly flexible; thus buckles and wrinkles can be easily generated and play vital roles in the corresponding physical properties. Here we introduce one kind of patterned buckling behavior caused by the delamination from a substrate initiated at the edges of the chemical vapor deposition synthesized monolayer transition metal dichalcogenides, led by thermal expansion mismatch. The atomic force microscopy and optical characterizations clearly showed the puckered structures associated with the strain, whereas the transmission electron microscopy revealed the special sawtooth-shaped edges, which break the geometrical symmetry for the buckling behavior of hexagonal samples. The condition of the edge delamination is in accordance with the fracture behavior of thin film interfaces. This edge delamination and buckling process is universal for most ultrathin two-dimensional materials, which requires more attention in various future applications.

  16. Evaluation of alternative snow plow cutting edges.

    Science.gov (United States)

    2009-05-01

    With approximately 450 snow plow trucks, the Maine Department of Transportation (MaineDOT) uses in : excess of 10,000 linear feet of plow cutting edges each winter season. Using the 2008-2009 cost per linear : foot of $48.32, the Departments total co...

  17. Edge diagnostics for tandem mirror machines

    International Nuclear Information System (INIS)

    Allen, S.L.

    1984-01-01

    The edge plasma in a tandem mirror machine shields the plasma core from cold neutral gas and impurities. A variety of diagnostics are used to measure the fueling, shielding, and confinement of the edge plasma in both the end plug and central cell regions. Fast ion gauges and residual gas analyzers measure the gas pressure and composition outside of the plasma. An array of Langmuir probes is used to measure the electron density and temperature. Extreme ultraviolet (euv) and visible spectroscopy are used to measure both the impurity and deuterium densities and to estimate the shielding factor for the core plasma. The linear geometry of a tandem mirror also allows direct measurements of the edge plasma by sampling the ions and electrons lost but the ends of the machine. Representative data obtained by these diagnostics during operation of the Tandem Mirror Experiment (TMX) and Tandem Mirror Experiment-Upgrade (TMX-U) experiments are presented. Diagnostics that are currently being developed to diagnose the edge plasma are also discussed

  18. Commercial Technology at the Tactical Edge

    Science.gov (United States)

    2013-06-01

    Software defined Networking ( SDN ), Autonomic Networking , and Cognitive Radios for Spectrum Sharing. Software defined ...www.opennetworking.org/. 41 Pan, P., “ Software Defined Network ( SDN ) Problem Statement and Use Cases for Data Center Applications,” IETF, 2011, http://tools.ietf.org/id...routinely at the tactical edge in the near future. These include software defined networking , autonomous networks , cognitive

  19. Acoustic streaming of a sharp edge.

    Science.gov (United States)

    Ovchinnikov, Mikhail; Zhou, Jianbo; Yalamanchili, Satish

    2014-07-01

    Anomalous acoustic streaming is observed emanating from sharp edges of solid bodies that are vibrating in fluids. The streaming velocities can be orders of magnitude higher than expected from the Rayleigh streaming at similar amplitudes of vibration. Acoustic velocity of fluid relative to a solid body diverges at a sharp edge, giving rise to a localized time-independent body force acting on the fluid. This force results in a formation of a localized jet. Two-dimensional numerical simulations are performed to predict acoustic streaming for low amplitude vibration using two methods: (1) Steady-state solution utilizing perturbation theory and (2) direct transient solution of the Navier-Stokes equations. Both analyses agree with each other and correctly predict the streaming of a sharp-edged vibrating blade measured experimentally. The origin of the streaming can be attributed to the centrifugal force of the acoustic fluid flow around a sharp edge. The dependence of this acoustic streaming on frequency and velocity is examined using dimensional analysis. The dependence law is devised and confirmed by numerical simulations.

  20. Edge-disjoint Hamiltonian cycles in hypertournaments

    DEFF Research Database (Denmark)

    Thomassen, Carsten

    2006-01-01

    We introduce a method for reducing k-tournament problems, for k >= 3, to ordinary tournaments, that is, 2-tournaments. It is applied to show that a k-tournament on n >= k + 1 + 24d vertices (when k >= 4) or on n >= 30d + 2 vertices (when k = 3) has d edge-disjoint Hamiltonian cycles if and only...