Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State

Science.gov (United States)

Amin, Shilu; Donaldson, Ian J.; Zannino, Denise A.; Hensman, James; Rattray, Magnus; Losa, Marta; Spitz, François; Ladam, Franck; Sagerström, Charles; Bobola, Nicoletta

2015-01-01

Summary Hox transcription factors (TFs) are essential for vertebrate development, but how these evolutionary conserved proteins function in vivo remains unclear. Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofactors, mainly homeodomain TFs Pbx and Meis, to select their specific targets. We mapped binding of Meis, Pbx, and Hoxa2 in the branchial arches, a series of segments in the developing vertebrate head. Meis occupancy is largely similar in Hox-positive and -negative arches. Hoxa2, which specifies second arch (IIBA) identity, recognizes a subset of Meis prebound sites that contain Hox motifs. Importantly, at these sites Meis binding is strongly increased. This enhanced Meis binding coincides with active enhancers, which are linked to genes highly expressed in the IIBA and regulated by Hoxa2. These findings show that Hoxa2 operates as a tissue-specific cofactor, enhancing Meis binding to specific sites that provide the IIBA with its anatomical identity. PMID:25640223

Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion.

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Michelle Erin Miller

Full Text Available Meis1 is recognized as an important transcriptional regulator in hematopoietic development and is strongly implicated in the pathogenesis of leukemia, both as a Hox transcription factor co-factor and independently. Despite the emerging recognition of Meis1's importance in the context of both normal and leukemic hematopoiesis, there is not yet a full understanding of Meis1's functions and the relevant pathways and genes mediating its functions. Recently, several conditional mouse models for Meis1 have been established. These models highlight a critical role for Meis1 in adult mouse hematopoietic stem cells (HSCs and implicate reactive oxygen species (ROS as a mediator of Meis1 function in this compartment. There are, however, several reported differences between these studies in terms of downstream progenitor populations impacted and effectors of function. In this study, we describe further characterization of a conditional knockout model based on mice carrying a loxP-flanked exon 8 of Meis1 which we crossed onto the inducible Cre localization/expression strains, B6;129-Gt(ROSA26Sor(tm1(Cre/ERTNat/J or B6.Cg-Tg(Mx1-Cre1Cgn/J. Findings obtained from these two inducible Meis1 knockout models confirm and extend previous reports of the essential role of Meis1 in adult HSC maintenance and expansion and provide new evidence that highlights key roles of Meis1 in both megakaryopoiesis and erythropoiesis. Gene expression analyses point to a number of candidate genes involved in Meis1's role in hematopoiesis. Our data additionally support recent evidence of a role of Meis1 in ROS regulation.

De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux.

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Fujita, Atsushi; Isidor, Bertrand; Piloquet, Hugues; Corre, Pierre; Okamoto, Nobuhiko; Nakashima, Mitsuko; Tsurusaki, Yoshinori; Saitsu, Hirotomo; Miyake, Noriko; Matsumoto, Naomichi

2016-09-01

MEIS2 aberrations are considered to be the cause of intellectual disability, cleft palate and cardiac septal defect, as MEIS2 copy number variation is often observed with these phenotypes. To our knowledge, only one nucleotide-level change-specifically, an in-frame MEIS2 deletion-has so far been reported. Here, we report a female patient with a de novo nonsense mutation (c.611C>G, p.Ser204*) in MEIS2. She showed severe intellectual disability, moderate motor/verbal developmental delay, cleft palate, cardiac septal defect, hypermetropia, severe feeding difficulties with gastro-esophageal reflux and constipation. By reviewing this patient and previous patients with MEIS2 point mutations, we found that feeding difficulty with gastro-esophageal reflux appears to be one of the core clinical features of MEIS2 haploinsufficiency, in addition to intellectual disability, cleft palate and cardiac septal defect.

Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation

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Mohammed M. Islam

2013-09-01

The transcription factor forkhead box N4 (Foxn4 is a key regulator in a variety of biological processes during development. In particular, Foxn4 plays an essential role in the genesis of horizontal and amacrine neurons from neural progenitors in the vertebrate retina. Although the functions of Foxn4 have been well established, the transcriptional regulation of Foxn4 expression during progenitor cell differentiation remains unclear. Here, we report that an evolutionarily conserved 129 bp noncoding DNA fragment (Foxn4CR4.2 or CR4.2, located ∼26 kb upstream of Foxn4 transcription start site, functions as a cis-element for Foxn4 regulation. CR4.2 directs gene expression in Foxn4-positive cells, primarily in progenitors, differentiating horizontal and amacrine cells. We further determined that the gene regulatory activity of CR4.2 is modulated by Meis1 binding motif, which is bound and activated by Meis1 transcription factor. Deletion of the Meis1 binding motif or knockdown of Meis1 expression abolishes the gene regulatory activity of CR4.2. In addition, knockdown of Meis1 expression diminishes the endogenous Foxn4 expression and affects cell lineage development. Together, we demonstrate that CR4.2 and its interacting Meis1 transcription factor play important roles in regulating Foxn4 expression during early retinogenesis. These findings provide new insights into molecular mechanisms that govern gene regulation in retinal progenitors and specific cell lineage development.

Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.

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Longobardi, E; Penkov, D; Mateos, D; De Florian, G; Torres, M; Blasi, Francesco

2014-01-01

TALE (three amino acids loop extension) homeodomain transcription factors are required in various steps of embryo development, in many adult physiological functions, and are involved in important pathologies. This review focuses on the PREP, MEIS, and PBX sub-families of TALE factors and aims at giving information on their biochemical properties, i.e., structure, interactors, and interaction surfaces. Members of the three sets of protein form dimers in which the common partner is PBX but they can also directly interact with other proteins forming higher-order complexes, in particular HOX. Finally, recent advances in determining the genome-wide DNA-binding sites of PREP1, MEIS1, and PBX1, and their partial correspondence with the binding sites of some HOX proteins, are reviewed. These studies have generated a few general rules that can be applied to all members of the three gene families. PREP and MEIS recognize slightly different consensus sequences: PREP prefers to bind to promoters and to have PBX as a DNA-binding partner; MEIS prefers HOX as partner, and both PREP and MEIS drive PBX to their own binding sites. This outlines the clear individuality of the PREP and MEIS proteins, the former mostly devoted to basic cellular functions, the latter more to developmental functions. Copyright © 2013 Wiley Periodicals, Inc.

Conformal invariance and conserved quantities of Appell systems under second-class Mei symmetry

International Nuclear Information System (INIS)

Yi-Ping, Luo; Jing-Li, Fu

2010-01-01

In this paper we introduce the new concept of the conformal invariance and the conserved quantities for Appell systems under second-class Mei symmetry. The one-parameter infinitesimal transformation group and infinitesimal transformation vector of generator are described in detail. The conformal factor in the determining equations under second-class Mei symmetry is found. The relationship between Appell system's conformal invariance and Mei symmetry are discussed. And Appell system's conformal invariance under second-class Mei symmetry may lead to corresponding Hojman conserved quantities when the conformal invariance satisfies some conditions. Lastly, an example is provided to illustrate the application of the result. (general)

mei-9/sup a/ mutant of Drosophila melanogaster increases mutagen sensitivity and decreases excision repair

International Nuclear Information System (INIS)

Boyd, J.B.; Golino, M.D.; Setlow, R.B.

1976-01-01

The mei-9/sup a/ mutant of Drosophila melanogaster, which reduces meiotic recombination in females, is deficient in the excision of uv-induced pyrimidine dimers in both sexes. Assays were performed in primary cultures and established cell lines derived from embryos. An endonuclease preparation from M. luteus, which is specific for pyrimidine dimers, was employed to monitor uv-induced dimers in cellular DNA. The rate of disappearance of endonuclease-sensitive sites from DNA of control cells is 10-20 times faster than that from mei-9/sup a/ cells. The mutant mei-218, which is also deficient in meiotic recombination, removes nuclease-sensitive sites at control rates. The mei-9/sup a/ cells exhibit control levels of photorepair, postreplication repair and repair of single strand breaks. In mei-9 cells DNA synthesis and possibly postreplication repair are weakly sensitive to caffeine. Larvae which are hemizygous for either of the two mutants that define the mei-9 locus are hypersensitive to killing by the mutagens methyl methanesulfonate, nitrogen mustard and 2-acetylaminofluorene. Larvae hemizygous for the mei-218 mutant are insensitive to each of these reagents. These data demonstrate that the mei-9 locus is active in DNA repair of somatic cells. Thus functions involved in meiotic recombination are also active in DNA repair in this higher eukaryote. The results are consistent with the earlier suggestions that the mei-9 locus functions in the exchange events of meiosis. The mei-218 mutation behaves differently in genetic tests and our data suggest its function may be restricted to meiosis. These studies demonstrate that currently recognized modes of DNA repair can be efficiently detected in primary cell cultures derived from Drosophila embryos

Basic Theory of Fractional Conformal Invariance of Mei Symmetry and its Applications to Physics

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Luo, Shao-Kai; Dai, Yun; Yang, Ming-Jing; Zhang, Xiao-Tian

2018-04-01

In this paper, we present a basic theory of fractional dynamics, i.e., the fractional conformal invariance of Mei symmetry, and find a new kind of conserved quantity led by fractional conformal invariance. For a dynamical system that can be transformed into fractional generalized Hamiltonian representation, we introduce a more general kind of single-parameter fractional infinitesimal transformation of Lie group, the definition and determining equation of fractional conformal invariance are given. And then, we reveal the fractional conformal invariance of Mei symmetry, and the necessary and sufficient condition whether the fractional conformal invariance would be the fractional Mei symmetry is found. In particular, we present the basic theory of fractional conformal invariance of Mei symmetry and it is found that, using the new approach, we can find a new kind of conserved quantity; as a special case, we find that an autonomous fractional generalized Hamiltonian system possesses more conserved quantities. Also, as the new method's applications, we, respectively, find the conserved quantities of a fractional general relativistic Buchduhl model and a fractional Duffing oscillator led by fractional conformal invariance of Mei symmetry.

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors.

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Kolb, Jasmine; Anders-Maurer, Marie; Müller, Tanja; Hau, Ann-Christin; Grebbin, Britta Moyo; Kallenborn-Gerhardt, Wiebke; Behrends, Christian; Schulte, Dorothea

2018-04-10

Adult neurogenesis is regulated by stem cell niche-derived extrinsic factors and cell-intrinsic regulators, yet the mechanisms by which niche signals impinge on the activity of intrinsic neurogenic transcription factors remain poorly defined. Here, we report that MEIS2, an essential regulator of adult SVZ neurogenesis, is subject to posttranslational regulation in the SVZ olfactory bulb neurogenic system. Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1. Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation. Our results describe a form of posttranscriptional modulation of adult SVZ neurogenesis whereby an extrinsic signal fine-tunes neurogenesis through posttranslational modification of a transcriptional regulator of cell fate. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Comportamiento meiótico de diferentes especies de lulo, Solanum sp

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Nancy Maricela Pareja Ordóñez

2010-10-01

Full Text Available Se realizó un análisis del comportamiento meiótico de las especies de lulo S. hirtum, S. quitoense y S. sessiliflorum, siguiendo la metodología convencional para los estudios de microsporogénesis. Se tomaron botones florales en diferentes estados de desarrollo, fijándolos por 24 horas en una solución de tres partes de etanol por una parte de ácido acético, saturada con trazas de cristales de cloruro férrico. Para la preparación de las placas se siguió la técnica de aplastamiento, se liberaron las células madres del grano de polen y finalmente se hicieron las observaciones bajo microscopía de luz. El análisis mostró que la meiosis se presenta en longitudes de antera que van desde los 2,79 mm hasta los 4,45 mm. La normalidad meiótica fue del 100%, tanto para meiosis I, como para la meiosis II. El índice meiótico en las tres especies fue del 99,98% lo cual indica que son buenos parentales y que pueden utilizarse en programas de cruzamiento. Las tres especies evaluadas tienen igual número de cromosomas (2n=2X=24. La frecuencia de anormalidades durante el proceso meiótico fue baja para S. hirtum, y alta para S. quitoense; sin embargo, la viabilidad polínica fue de gran magnitud (91,2-97,3%.

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors

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Jasmine Kolb

2018-04-01

Full Text Available Summary: Adult neurogenesis is regulated by stem cell niche-derived extrinsic factors and cell-intrinsic regulators, yet the mechanisms by which niche signals impinge on the activity of intrinsic neurogenic transcription factors remain poorly defined. Here, we report that MEIS2, an essential regulator of adult SVZ neurogenesis, is subject to posttranslational regulation in the SVZ olfactory bulb neurogenic system. Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1. Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation. Our results describe a form of posttranscriptional modulation of adult SVZ neurogenesis whereby an extrinsic signal fine-tunes neurogenesis through posttranslational modification of a transcriptional regulator of cell fate. : A hallmark of adult neurogenesis is its strong dependence on physiological stimuli and environmental signals. Schulte and colleagues show that the nuclear localization and activity of a transcriptional regulator of adult neurogenesis is controlled by posttranslational modification. Their results link intrinsic control over neuron production to external signals and help to explain how adult neurogenesis can occur “on demand.” Keywords: subventricular zone, stem cell niche, posttranslational modification, controlled nuclear import, TALE-homdomain protein, MEIS2, PBX1, CRM1, neurogenesis, stem cell niche

Visual analysis and Schmidt rebound hammer test of Taj-ul-Masajid

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A. Hussain

2017-09-01

Full Text Available Taj-ul-Masajid, literally, the crown among mosques is an embodiment of genius structural engineering located in the heart of Madhya Pradesh, Bhopal. A unique combination of the Mughal Architecture in complete stone masonry and modern day RCC work, it is a liaison between the past and the present of structural engineering. A wonder in its own right, the structure is often neglected by technicians and conservationalists alike, a satire on their ingenuity. Now, in a severely dilapidated condition, the structure is in pressing need of structural rehabilitation. The authors intend to perform in-situ Non-Destructive Testing & Evaluation (NDT&E of this structure and thereby suggest steps to better its present condition. As a first step, they’ve performed the visual analysis and Schmidt Rebound Hammer Test on the concrete portion of the structure which has been presented herein. The authors have also suggested a new approach for the verification of results obtained.

Press Reviews of Mei Lanfang in the Soviet Union, 1935, by Female Writers: Neher Versus Shaginyan

DEFF Research Database (Denmark)

Risum, Janne

2016-01-01

There are two interesting female exceptions to the all-male chorus reviewing the Chinese performer of female roles Mei Lanfang and his troupe in the local newspapers during Mei's Soviet tour in the spring of 1935. One is the well-established Russian writer Marietta Shaginyan (1888-1982), whose......, and to uncover why Neher's expert professional analysis has so far been unduly and sadly neglected. To further set off their contrasting views of Mei Lanfang and Chinese theatre, I compare these to the more well-known viewpoints of Sergei Tretyakov and Bertolt Brecht....

Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb.

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Mason, Mandy K; Hockman, Dorit; Curry, Lyle; Cunningham, Thomas J; Duester, Gregg; Logan, Malcolm; Jacobs, David S; Illing, Nicola

2015-01-01

The bat has strikingly divergent forelimbs (long digits supporting wing membranes) and hindlimbs (short, typically free digits) due to the distinct requirements of both aerial and terrestrial locomotion. During embryonic development, the morphology of the bat forelimb deviates dramatically from the mouse and chick, offering an alternative paradigm for identifying genes that play an important role in limb patterning. Using transcriptome analysis of developing Natal long-fingered bat (Miniopterus natalensis) fore- and hindlimbs, we demonstrate that the transcription factor Meis2 has a significantly higher expression in bat forelimb autopods compared to hindlimbs. Validation by reverse transcriptase and quantitative polymerase chain reaction (RT-qPCR) and whole mount in situ hybridisation shows that Meis2, conventionally known as a marker of the early proximal limb bud, is upregulated in the bat forelimb autopod from CS16. Meis2 expression is localised to the expanding interdigital webbing and the membranes linking the wing to the hindlimb and tail. In mice, Meis2 is also expressed in the interdigital region prior to tissue regression. This interdigital Meis2 expression is not activated by retinoic acid (RA) signalling as it is present in the retained interdigital tissue of Rdh10 (trex/trex) mice, which lack RA. Additionally, genes encoding RA-synthesising enzymes, Rdh10 and Aldh1a2, and the RA nuclear receptor Rarβ are robustly expressed in bat fore- and hindlimb interdigital tissues indicating that the mechanism that retains interdigital tissue in bats also occurs independently of RA signalling. Mammalian interdigital Meis2 expression, and upregulation in the interdigital webbing of bat wings, suggests an important role for Meis2 in autopod development. Interdigital Meis2 expression is RA-independent, and retention of interdigital webbing in bat wings is not due to the suppression of RA-induced cell death. Rather, RA signalling may play a role in the thinning

A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer.

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Blasi, Francesco; Bruckmann, Chiara; Penkov, Dmitry; Dardaei, Leila

2017-05-01

We report the latest structural information on PREP1 tumor suppressor, the specific "oncogene" and "tumor suppressive" signatures of MEIS1 and PREP1, the molecular rules regulating PREP1 and MEIS1 binding to DNA, and how these can change depending on the interaction with PBX1, cell-type, neoplastic transformation, and intracellular concentration. As both PREP1 and MEIS1 interact with PBX1 they functionally compete with each other. PREP1, PBX1, and MEIS1 TALE-class homeodomain transcription factors act in an interdependent and integrated way in experimental tumorigenesis. We also pool together the plethora of data available in human cancer databanks and connect them with the available molecular information. The emerging picture suggests that a similarly basic approach might be used to better dissect and define other oncogenes and suppressors and better understand human cancer. © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc.

Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis.

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Johnson, Jacque-Lynne F A; Lu, Chenggang; Raharjo, Eko; McNally, Karen; McNally, Francis J; Mains, Paul E

2009-06-15

The MEI-1/MEI-2 microtubule-severing complex, katanin, is required for oocyte meiotic spindle formation and function in C. elegans, but the microtubule-severing activity must be quickly downregulated so that it does not interfere with formation of the first mitotic spindle. Post-meiotic MEI-1 inactivation is accomplished by two parallel protein degradation pathways, one of which requires MEL-26, the substrate-specific adaptor that recruits MEI-1 to a CUL-3 based ubiquitin ligase. Here we address the question of how MEL-26 mediated MEI-1 degradation is triggered only after the completion of MEI-1's meiotic function. We find that MEL-26 is present only at low levels until the completion of meiosis, after which protein levels increase substantially, likely increasing the post-meiotic degradation of MEI-1. During meiosis, MEL-26 levels are kept low by the action of another type of ubiquitin ligase, which contains CUL-2. However, we find that the low levels of meiotic MEL-26 have a subtle function, acting to moderate MEI-1 activity during meiosis. We also show that MEI-1 is the only essential target for MEL-26, and possibly for the E3 ubiquitin ligase CUL-3, but the upstream ubiquitin ligase activating enzyme RFL-1 has additional essential targets.

Mei symmetry and conservation laws of discrete nonholonomic dynamical systems with regular and irregular lattices

International Nuclear Information System (INIS)

Zhao Gang-Ling; Chen Li-Qun; Fu Jing-Li; Hong Fang-Yu

2013-01-01

In this paper, Noether symmetry and Mei symmetry of discrete nonholonomic dynamical systems with regular and the irregular lattices are investigated. Firstly, the equations of motion of discrete nonholonomic systems are introduced for regular and irregular lattices. Secondly, for cases of the two lattices, based on the invariance of the Hamiltomian functional under the infinitesimal transformation of time and generalized coordinates, we present the quasi-extremal equation, the discrete analogues of Noether identity, Noether theorems, and the Noether conservation laws of the systems. Thirdly, in cases of the two lattices, we study the Mei symmetry in which we give the discrete analogues of the criterion, the theorem, and the conservative laws of Mei symmetry for the systems. Finally, an example is discussed for the application of the results

Egoísmo de tres cuartillos: el sabotaje de los hacendados al tajón público de carnes en Santafé, 1798-1817

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Sergio Mejía

2015-01-01

Full Text Available Se estudia una serie de anomalías en el abasto de carnes de Santafé de Bogotá entre 1798 y 1817, causadas por la reticencia de los hacendados a acatar la orden del virrey Mendinueta de expender sus productos en una nueva carnicería o tajón en el centro de la ciudad. Decididos a no pagar el acarreo correspondiente, y valiéndose del cabildo (del que eran dueños, estos hacendados terminaron por imponer su voluntad sobre el virrey, quien transigió con un aumento del 50 % en el precio de la carne, a cambio de establecer el tajón. El caso muestra la debilidad del Estado colonial en sus postrimerías y pone en evidencia el egoísmo ante lo público de los potentados santafereños, que, al cabo de dos años, se convirtieron en beneméritos republicanos. Se usan papeles de los fondos: Abastos, Milicias y Marina, Miscelánea de la Colonia y Gobierno del Archivo General de la Nación de Bogotá.

The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis.

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Lu, Chenggang; Mains, Paul E

2007-02-15

The C. elegans embryo supports both meiotic and mitotic spindles, requiring careful regulation of components specific to each spindle type. The MEI-1/katanin microtubule-severing complex is required for meiosis but must be inactivated prior to mitosis. Downregulation of MEI-1 depends on MEL-26, which binds MEI-1, targeting it for degradation by the CUL-3 E3 ubiquitin ligase complex. Here we report that other protein degradation pathways, involving the anaphase promoting complex (APC) and the MBK-2/DYRK kinase, act in parallel to MEL-26 to inactivate MEI-1. At 25 degrees all mel-26(null) embryos die due to persistence of MEI-1 into mitosis, but at 15 degrees a significant portion of embryos hatch due to lower levels of ectopic MEI-1, suggesting that a redundant pathway also regulates MEI-1 degradation at 15 degrees. Previously the MBK-2/DYRK kinase was suggested to trigger MEL-26 mediated MEI-1 degradation. However, mbk-2 enhances the incomplete lethality of mel-26(null) at 15 degrees, arguing that MEL-26 acts in parallel to MBK-2. APC mutants behave similarly. In mel-26 embryos, ectopic MEI-1 remains until the onset of gastrulation, but in mbk-2; apc embryos, MEI-1 only persists through the first mitosis. We propose that mbk-2 and apc couple the initial phase of MEI-1 degradation to meiotic exit, after which MEL-26 completes MEI-1 degradation.

Malaysian Education Index (MEI): An Online Indexing and Repository System

Science.gov (United States)

Kabilan, Muhammad Kamarul; Ismail, Hairul Nizam; Yaakub, Rohizani; Yusof, Najeemah Mohd; Idros, Sharifah Noraidah Syed; Umar, Irfan Naufal; Arshad, Muhammad Rafie Mohd.; Idrus, Rosnah; Rahman, Habsah Abdul

2010-01-01

This "Project Sheet" describes an on-going project that is being carried out by a group of educational researchers, computer science researchers and librarians from Universiti Sains Malaysia, Penang. The Malaysian Education Index (MEI) has two main functions--(1) Online Indexing System, and (2) Online Repository System. In this brief…

Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR.

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Liu, Niankun; Han, Hong; Lasko, Paul

2009-12-01

Vasa (Vas) is a DEAD-box RNA-binding protein required in Drosophila at several steps of oogenesis and for primordial germ cell (PGC) specification. Vas associates with eukaryotic initiation factor 5B (eIF5B), and this interaction has been implicated in translational activation of gurken mRNA in the oocyte. Vas is expressed in all ovarian germline cells, and aspects of the vas-null phenotype suggest a function in regulating the balance between germline stem cells (GSCs) and their fate-restricted descendants. We used a biochemical approach to recover Vas-associated mRNAs and obtained mei-P26, whose product represses microRNA activity and promotes GSC differentiation. We found that vas and mei-P26 mutants interact, and that mei-P26 translation is substantially reduced in vas mutant cells. In vitro, Vas protein bound specifically to a (U)-rich motif in the mei-P26 3' untranslated region (UTR), and Vas-dependent regulation of GFP-mei-P26 transgenes in vivo was dependent on the same (U)-rich 3' UTR domain. The ability of Vas to activate mei-P26 expression in vivo was abrogated by a mutation that greatly reduces its interaction with eIF5B. Taken together, our data support the conclusion that Vas promotes germ cell differentiation by directly activating mei-P26 translation in early-stage committed cells.

Biochemical studies of DNA strand break repair and molecular characterization of mei-41, a gene involved in DNA break repair

International Nuclear Information System (INIS)

Oliveri, D.R.

1989-01-01

The ability to repair X-irradiation induced single-strand DNA breaks was examined in mutagen-sensitive mutants of Drosophila melanogaster. This analysis demonstrated that examined stocks possess a normal capacity to repair X-ray induced single-strand breaks. One of the mutants in this study, mei-41, has been shown to be involved in a number of DNA metabolizing functions. A molecular characterization of this mutant is presented. A cDNA hybridizing to genomic DNA both proximal and distal to a P element inducing a mei-41 mutation was isolated from both embryonic and adult female recombinant lambda phage libraries. A 2.2 kilobase embryonic cDNA clone was sequenced; the sequence of an open reading frame was identified which would predict a protein of 384 amino acids with a molecular weight of 43,132 daltons. An examination of homologies to sequences in protein and nucleic acid data bases revealed no sequences with significant homology to mei-41, however, two potential Zinc-finger domains were identified. Analysis of RNA hybridizing to the embryonic cDNA demonstrated the existence of a major 2.2 kilobase transcript expressed primarily in embryos and adult flies. An examination of the transcription of this gene in mei-41 mutants revealed significant variation from wild-type, an indication that the embryonic cDNA does represent a mei-41 transcript. Expression in tissues from adult animals demonstrated that the 2.2 kilobase RNA is expressed primarily in reproductive tissues. A 3.8kb transcript is the major species of RNA in the adult head and thorax. Evidence is presented which implies that expression of the mei-41 gene is strongly induced by exposure of certain cells to mutagens

Medium energy ion scattering (MEIS)

International Nuclear Information System (INIS)

Dittmann, K.; Markwitz, A.

2009-01-01

This report gives an overview about the technique and experimental study of medium energy ion scattering (MEIS) as a quantitative technique to determine and analyse the composition and geometrical structure of crystalline surfaces and near surface-layers by measuring the energy and yield of the backscattered ions. The use of a lower energy range of 50 to 500 keV accelerated ions impinging onto the target surface and the application of a high-resolution electrostatic energy analyser (ESA) makes medium energy ion scattering spectroscopy into a high depth resolution and surface-sensitive version of RBS with less resulting damage effects. This report details the first steps of research in that field of measurement technology using medium energetic backscattered ions detected by means of a semiconductor radiation detector instead of an ESA. The study of medium energy ion scattering (MEIS) has been performed using the 40 keV industrial ion implanter established at GNS Sciences remodelled with supplementary high voltage insulation for the ion source in order to apply voltages up to 45 kV, extra apertures installed in the beamline and sample chamber in order to set the beam diameter accurately, and a semiconductor radiation detector. For measurement purposes a beam of positive charged helium ions accelerated to an energy of about 80 keV has been used impinging onto target surfaces of lead implanted into silicon (PbSi), scandium implanted into aluminium (ScAl), aluminium foil (Al) and glassy carbon (C). First results show that it is possible to use the upgraded industrial implanter for medium energy ion scattering. The beam of 4 He 2+ with an energy up to 88 keV has been focussed to 1 mm in diameter. The 5 nA ion beam hit the samples under 2 x 10 -8 mbar. The results using the surface barrier detector show scattering events from the samples. Cooling of the detector to liquid nitrogen temperatures reduced the electronic noise in the backscattering spectrum close to zero. A

Meis2 is essential for cranial and cardiac neural crest development

Czech Academy of Sciences Publication Activity Database

Machoň, Ondřej; Mašek, Jan; Machoňová, Olga; Krauss, S.; Kozmik, Zbyněk

2015-01-01

Roč. 15, Nov 6 (2015) ISSN 1471-213X R&D Projects: GA ČR GAP305/12/2042; GA MŠk(CZ) LK11214 Institutional support: RVO:68378050 Keywords : Meis2 * Persistent truncus arteriosus * Neural crest * Craniofacial skeleton * Cranial nerves Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.096, year: 2015

CREB, NF-Y and MEIS1 conserved binding sites are essential to balance Myostatin promoter/enhancer activity during early myogenesis.

Science.gov (United States)

Grade, Carla Vermeulen Carvalho; Mantovani, Carolina Stefano; Fontoura, Marina Alves; Yusuf, Faisal; Brand-Saberi, Beate; Alvares, Lúcia Elvira

2017-10-01

Myostatin (MSTN) is a strong inhibitor of skeletal muscle growth in human and other vertebrates. Its transcription is controlled by a proximal promoter/enhancer (Mstn P/E) containing a TATA box besides CREB, NF-Y, MEIS1 and FXR transcription factor binding sites (TFBSs), which are conserved throughout evolution. The aim of this work was to investigate the role of these TFBSs on Mstn P/E activity and evaluate the potential of their putative ligands as Mstn trans regulators. Mstn P/E mutant constructs were used to establish the role of conserved TFBSs using dual-luciferase assays. Expression analyses were performed by RT-PCR and in situ hybridization in C2C12 myoblasts and E10.5 mouse embryos, respectively. Our results revealed that CREB, NF-Y and MEIS1 sites are required to balance Mstn P/E activity, keeping Mstn transcription within basal levels during myoblast proliferation. Furthermore, our data showed that NF-Y site is essential, although not sufficient, to mediate Mstn P/E transcriptional activity. In turn, CREB and MEIS1 binding sites seem to depend on the presence of NF-Y site to induce Mstn P/E. FXR appears not to confer any effect on Mstn P/E activity, except in the absence of all other conserved TFBS. Accordingly, expression studies pointed to CREB, NF-Y and MEIS1 but not to FXR factors as possible regulators of Mstn transcription in the myogenic context. Altogether, our findings indicated that CREB, NF-Y and MEIS1 conserved sites are essential to control basal Mstn transcription during early myogenesis, possibly by interacting with these or other related factors.

Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis.

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Aseervatham Anusha Amali

Full Text Available Mice lacking the 4th-group paralog Hoxd4 display malformations of the anterior vertebral column, but are viable and fertile. Here, we report that zebrafish embryos having decreased function of the orthologous hoxd4a gene manifest striking perturbations in vasculogenesis, angiogenesis and primitive and definitive hematopoiesis. These defects are preceded by reduced expression of the hemangioblast markers scl1, lmo2 and fli1 within the posterior lateral plate mesoderm (PLM at 13 hours post fertilization (hpf. Epistasis analysis revealed that hoxd4a acts upstream of meis1.1 but downstream of cdx4 as early as the shield stage in ventral-most mesoderm fated to give rise to hemangioblasts, leading us to propose that loss of hoxd4a function disrupts hemangioblast specification. These findings place hoxd4a high in a genetic hierarchy directing hemangioblast formation downstream of cdx1/cdx4 and upstream of meis1.1. An additional consequence of impaired hoxd4a and meis1.1 expression is the deregulation of multiple Hox genes implicated in vasculogenesis and hematopoiesis which may further contribute to the defects described here. Our results add to evidence implicating key roles for Hox genes in their initial phase of expression early in gastrulation.

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21

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Xiaoye Liu

2018-05-01

Full Text Available Summary: In addition to acting as building blocks for biosynthesis, amino acids might serve as signaling regulators in various physiological and pathological processes. However, it remains unknown whether amino acid levels affect the activities of hematopoietic stem cells (HSCs. By using a genetically encoded fluorescent sensor of the intracellular levels of branched-chain amino acids (BCAAs, we could monitor the dynamics of BCAA metabolism in HSCs. A mitochondrial-targeted 2C-type Ser/Thr protein phosphatase (PPM1K promotes the catabolism of BCAAs to maintain MEIS1 and p21 levels by decreasing the ubiquitination-mediated degradation controlled by the E3 ubiquitin ligase CDC20. PPM1K deficiency led to a notable decrease in MEIS1/p21 signaling to reduce the glycolysis and quiescence of HSCs, followed by a severe impairment in repopulation activities. Moreover, the deletion of Ppm1k dramatically extended survival in a murine leukemia model. These findings will enhance the current understanding of nutrient signaling in metabolism and function of stem cells. : Liu et al. show that the dynamics of BCAA metabolism in hematopoietic stem cells (HSCs and leukemia-initiating cells (LICs can be monitored by a genetically encoded fluorescent sensor. PPM1K promotes BCAA catabolism and maintains the glycolysis and quiescence of HSCs/LICs through the downregulation of CDC20-mediated ubiquitination of MEIS1 and p21. Keywords: branched-chain amino acids, PPM1K, ubiquitination, CDC20, MEIS1/p21, hematopoietic stem cells, leukemia-initiating cells

Egoísmo de tres cuartillos: el sabotaje de los hacendados al tajón público de carnes en Santafé, 1798-1817

OpenAIRE

Sergio Mejía

2015-01-01

Se estudia una serie de anomalías en el abasto de carnes de Santafé de Bogotá entre 1798 y 1817, causadas por la reticencia de los hacendados a acatar la orden del virrey Mendinueta de expender sus productos en una nueva carnicería o tajón en el centro de la ciudad. Decididos a no pagar el acarreo correspondiente, y valiéndose del cabildo (del que eran dueños), estos hacendados terminaron por imponer su voluntad sobre el virrey, quien transigió con un aumento del 50 % en el precio de la carne...

Let me sing your songs: how Finns found xöömei

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Sauli Heikkilä

2017-06-01

Full Text Available The author of this essay, musician and founder of the Throat Singing Association of Finland (1997, tells the story of how an association of throat singing practitioners came to be in Finland, and how to teach this art to those wishing to learn it. The story also covers the author’s own musical preferences and his life-changing visit to a week-long workshop led by Boris Salchak from Tuva in 1995. Two years later, the author and other aficionados of Tuvan xöömei founded the Throat Singing Association and started holding festivals featuring invited Tuvan singers and throat singing courses. The author describes his collaboration with renowned Tuvan performers, as well as throat singing scholars from the USA, the Netherlands, UK, Italy, etc. The author holds that throat (or overtone singing is a special sound practice. Tuvan practices can be compared with similar techniques developed by indigenous peoples of Africa, North America, Japan and Tibet. Throat singing as a practice is closely linked to specific ancient worldviews of peoples and cultures living close to nature. Finns are also considered living in close proximity to nature, which may explain their partiality to throat signing. Dozens actively practice xöömei and hundreds have experienced it, which is a much larger percentage than in other European states. In the essay, the author also focuses on the throat singing courses he has been giving for a while and shares his observations of his students, their motivation, specific training techniques and adapting them to the desires and intentions of his students. He believes that almost everybody can learn singing, and most people can have a command of throat singing. The essay also covers the main problems that aspiring throat singers can face, as well as specific styles of the xöömei, concluding with the idea that it is impossible to master throat singing in a short period of time. The key to success is only found in regular and extensive

UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.

Science.gov (United States)

Wilson, Kristy J; Qadota, Hiroshi; Mains, Paul E; Benian, Guy M

2012-07-01

The ubiquitin proteasome system is involved in degradation of old or damaged sarcomeric proteins. Most E3 ubiquitin ligases are associated with cullins, which function as scaffolds for assembly of the protein degradation machinery. Cullin 3 uses an adaptor to link to substrates; in Caenorhabditis elegans, one of these adaptors is the BTB-domain protein MEL-26 (maternal effect lethal). Here we show that MEL-26 interacts with the giant sarcomeric protein UNC-89 (obscurin). MEL-26 and UNC-89 partially colocalize at sarcomeric M-lines. Loss of function or gain of function of mel-26 results in disorganization of myosin thick filaments similar to that found in unc-89 mutants. It had been reported that in early C. elegans embryos, a target of the CUL-3/MEL-26 ubiquitylation complex is the microtubule-severing enzyme katanin (MEI-1). Loss of function or gain of function of mei-1 also results in disorganization of thick filaments similar to unc-89 mutants. Genetic data indicate that at least some of the mel-26 loss-of-function phenotype in muscle can be attributed to increased microtubule-severing activity of MEI-1. The level of MEI-1 protein is reduced in an unc-89 mutant, suggesting that the normal role of UNC-89 is to inhibit the CUL-3/MEL-26 complex toward MEI-1.

Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary.

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Yun Li

Full Text Available In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.

Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary

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Li, Yun; Zhang, Qiao; Carreira-Rosario, Arnaldo; Maines, Jean Z.; McKearin, Dennis M.; Buszczak, Michael

2013-01-01

In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam. PMID:23526974

Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain

DEFF Research Database (Denmark)

Larsen, Karen B; Lutterodt, Melissa C; Laursen, Henning

2010-01-01

The development of the human neocortex is a complex and highly regulated process involving a time-related expression of many transcription factors including the homeobox genes Pax6 and Meis2. During early development, Pax6 is expressed in nuclei of radial glia cells in the neocortical proliferative...... in the same time window. We demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes are expressed during early fetal brain development in humans. PAX6 mRNA and protein were located in the proliferative zones of the neocortex and in single cells in the cortical preplate at 7...... in the proliferative zones of the human fetal neocortex and a higher expression of MEIS2 than PAX6 was observed in these areas at 9 fetal weeks. Further, MEIS2 was expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate....

Differential expression of Meis2, Mab21l2 and Tbx3 during limb development associated with diversification of limb morphology in mammals.

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Dai, Mengyao; Wang, Yao; Fang, Lu; Irwin, David M; Zhu, Tengteng; Zhang, Junpeng; Zhang, Shuyi; Wang, Zhe

2014-01-01

Bats are the only mammals capable of self-powered flight using wings. Differing from mouse or human limbs, four elongated digits within a broad wing membrane support the bat wing, and the foot of the bat has evolved a long calcar that spread the interfemoral membrane. Our recent mRNA sequencing (mRNA-Seq) study found unique expression patterns for genes at the 5' end of the Hoxd gene cluster and for Tbx3 that are associated with digit elongation and wing membrane growth in bats. In this study, we focused on two additional genes, Meis2 and Mab21l2, identified from the mRNA-Seq data. Using whole-mount in situ hybridization (WISH) we validated the mRNA-Seq results for differences in the expression patterns of Meis2 and Mab21l2 between bat and mouse limbs, and further characterize the timing and location of the expression of these two genes. These analyses suggest that Meis2 may function in wing membrane growth and Mab21l2 may have a role in AP and DV axial patterning. In addition, we found that Tbx3 is uniquely expressed in the unique calcar structure found in the bat hindlimb, suggesting a role for this gene in calcar growth and elongation. Moreover, analysis of the coding sequences for Meis2, Mab21l2 and Tbx3 showed that Meis2 and Mab21l2 have high sequence identity, consistent with the functions of genes being conserved, but that Tbx3 showed accelerated evolution in bats. However, evidence for positive selection in Tbx3 was not found, which would suggest that the function of this gene has not been changed. Together, our findings support the hypothesis that the modulation of the spatiotemporal expression patterns of multiple functional conserved genes control limb morphology and drive morphological change in the diversification of mammalian limbs.

ToF-MEIS stopping measurements in thin SiC films

International Nuclear Information System (INIS)

Linnarsson, M.K.; Khartsev, S.; Primetzhofer, D.; Possnert, G.; Hallén, A.

2014-01-01

Electronic stopping in thin, amorphous, SiC films has been studied by time-of-flight medium energy ion scattering and conventional Rutherford backscattering spectrometry. Amorphous SiC films (8, 21 and 36 nm) were prepared by laser ablation using a single crystalline silicon carbide target. Two kinds of substrate films, one with a lower atomic mass (carbon) and one with higher atomic mass (iridium) compared to silicon has been used. Monte Carlo simulations have been used to evaluate electronic stopping from the shift in energy for the signal scattered from Ir with and without SiC. The two kinds of samples are used to illustrate the strength and challenges for ToF-MEIS compared to conventional RBS

Zlatko Meić - The Recipient of the Annual State Reward for Science 2006

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Trinajstić, N.

2010-12-01

Full Text Available The life and career of Professor Zlatko Meić is described in some detail. He was born in 1938 in Šid (Srijem and educated in Varaždin (elementary school, 1945–1952 and high school, 1952–1957, and in Zagreb (Faculty of Technology, 1957–1962. He did diploma research under the guidance of Siniša Maričić at the Rugjer Bošković Institute. He obtained his master's degree in 1967 and soon after the Ph. D. in 1969 at the Faculty of Natural Sciences and Mathematics in Zagreb under the supervision of Professor Milan Randić. He spent his career at the Rugjer Bošković Institute and the Department of Chemistry, Faculty of Natural Sciences and Mathematics. His field of research was molecular spectroscopy where he made his mark and was internationally recognized for the high quality of his work. In the Department of Chemistry, he was associated with the Laboratory of Analytical Chemistry where he was the Head of the Laboratory from 2000 to 2007. There he modernized the teaching of analytical chemistry and introduced a new lecture course Identification of chemical compounds by spectroscopic methods. Professor Meić had many of students due to his likeable personality, and willingness to help students and younger colleagues seeking advice and encouragement.

The Narrative Analysis on the KangMei Pharmaceutical Advertisement%康美药业广告叙事学分析

Institute of Scientific and Technical Information of China (English)

张志华

2015-01-01

企业面对竞争激烈的市场，产品同质化的现状，如何创造广告传播的有效就成为其面临的难题之一。而康美药业股份有限公司作为相对年轻的药企，利用央视这一平台，采用音乐电视广告片的形式，并且多年坚持投放，使得企业品牌价值得到提升，企业形象深入人心。该文以康美药业广告音乐MV《康美之恋》为叙事文本，借助叙事学的相关理论，从叙事主体和接受主体两个方面进行分析，发现康美药业广告的成功之处在于其成功的叙事能力。%The fierce competition of market and the current situation of product homogeneity have made it a great problem for the validity of advertising communication. As a relatively young drug firms, KangMei Pharmaceutical Company makes full use of the platform of the CCTV, adopting the music television commercials and repeating the advertisement years after years. It is in this way that the KangMei Pharmaceutical Company has made a great success in enhancing the brand value and wining support for the cor⁃porate image. With the aid of relevant narrative theory, this thesis intends to analyze the narrative text of the KangMei Pharmaceuti⁃cal advertisement from the perspectives of narrative subject and acceptance subject, thus unveiling the key of the KangMei Pharma⁃ceutical advertisement’s success is its great narrative ability.

Caramel colour and process contaminants in foods and beverages: Part II - Occurrence data and exposure assessment of 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) and 4-methylimidazole (4-MEI) in Belgium.

Science.gov (United States)

Fierens, T; Van Holderbeke, M; Cornelis, C; Jacobs, G; Sioen, I; De Maeyer, M; Vinkx, C; Vanermen, G

2018-07-30

In Europe, 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) and 4-methylimidazole (4-MEI) are - to a certain level - allowed to be present in the food colours ammonia caramel (E 150c) and sulphite ammonia caramel (E 150d). Besides their presence in food colours, exposure to these contaminants may also include other dietary sources. This study describes the occurrence of THI and 4-MEI in a wide variety of food products (n = 522) purchased from the Belgian market and their dietary intake in Belgian consumers from 15 years old onwards. THI was found to be present in 22.4% of the investigated foods at a level up to 551 µg/kg. For 4-MEI (57.7% quantifiable), concentrations up to 2,835 µg/kg were observed. The average dietary intake amounted to 0.02-0.36 µg kg -1  bw -1  day for THI and 0.4-3.7 µg kg -1  bw -1  day for 4-MEI. Coffee, cola and beer were contributing most to the dietary THI and 4-MEI intake in Belgium. Copyright © 2018 Elsevier Ltd. All rights reserved.

The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal

Science.gov (United States)

Joly, Willy; Chartier, Aymeric; Rojas-Rios, Patricia; Busseau, Isabelle; Simonelig, Martine

2013-01-01

Summary Translational regulation plays an essential role in Drosophila ovarian germline stem cell (GSC) biology. GSC self-renewal requires two translational repressors, Nanos (Nos) and Pumilio (Pum), which repress the expression of differentiation factors in the stem cells. The molecular mechanisms underlying this translational repression remain unknown. Here, we show that the CCR4 deadenylase is required for GSC self-renewal and that Nos and Pum act through its recruitment onto specific mRNAs. We identify mei-P26 mRNA as a direct and major target of Nos/Pum/CCR4 translational repression in the GSCs. mei-P26 encodes a protein of the Trim-NHL tumor suppressor family that has conserved functions in stem cell lineages. We show that fine-tuning Mei-P26 expression by CCR4 plays a key role in GSC self-renewal. These results identify the molecular mechanism of Nos/Pum function in GSC self-renewal and reveal the role of CCR4-NOT-mediated deadenylation in regulating the balance between GSC self-renewal and differentiation. PMID:24286029

The CCR4 deadenylase acts with Nanos and Pumilio in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal.

Science.gov (United States)

Joly, Willy; Chartier, Aymeric; Rojas-Rios, Patricia; Busseau, Isabelle; Simonelig, Martine

2013-01-01

Translational regulation plays an essential role in Drosophila ovarian germline stem cell (GSC) biology. GSC self-renewal requires two translational repressors, Nanos (Nos) and Pumilio (Pum), which repress the expression of differentiation factors in the stem cells. The molecular mechanisms underlying this translational repression remain unknown. Here, we show that the CCR4 deadenylase is required for GSC self-renewal and that Nos and Pum act through its recruitment onto specific mRNAs. We identify mei-P26 mRNA as a direct and major target of Nos/Pum/CCR4 translational repression in the GSCs. mei-P26 encodes a protein of the Trim-NHL tumor suppressor family that has conserved functions in stem cell lineages. We show that fine-tuning Mei-P26 expression by CCR4 plays a key role in GSC self-renewal. These results identify the molecular mechanism of Nos/Pum function in GSC self-renewal and reveal the role of CCR4-NOT-mediated deadenylation in regulating the balance between GSC self-renewal and differentiation.

Abnormal meiotic behavior in three species of Crotalaria Comportamento meiótico anormal em três espécies de Crotalaria

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Kátia Ferreira

2009-12-01

Full Text Available The objective of this work was to compare the meiotic behavior and pollen grain viability of three species of Crotalaria. Slides for meiotic analysis were prepared by the air-drying technique. Pollen grain viability was measured by three staining procedures (Alexander's solution, tetrazolium chloride and fluorescein diacetate and in vitro germination in a sucrose solution. Eight bivalents were observed, confirming previous reports on populations from other regions of Brazil, as well as from other countries. All species showed abnormal meiotic behavior as follows: in Crotalaria micans, cytomixis and abnormal chromosome pairing in diakinesis; in C. spectabilis, abnormal chromosome pairing in diplotene; in C. zanzibarica, shrunk nuclei in leptotene and zygotene. Pollen grains of all three species show low viability, which may be associated with the irregularities of the meiotic behavior.O objetivo deste trabalho foi comparar o comportamento meiótico e a viabilidade dos grãos de pólen de três espécies de Crotalaria. A análise meiótica foi realizada por meio da técnica de secagem ao ar. A viabilidade dos grãos de pólen foi avaliada por testes de coloração (corante de Alexander, cloreto de tetrazólio e diacetato de fluoresceína e por teste de germinação em solução de sacarose. Foram observados oito bivalentes, confirmando relatos prévios em populações de outras regiões do Brasil e de outros países. As três espécies apresentaram comportamento meiótico irregular: em Crotalaria micans, citomixia e pareamento irregular na diacinese; em C. spectabilis, pareamento irregular no diplóteno; e em C. zanzibarica, núcleo fortemente condensado nas fases de leptóteno e zigóteno. A viabilidade dos grãos de pólen das três espécies é baixa, o que pode estar associado às irregularidades do comportamento meiótico.

Mei Symmetry and New Conserved Quantities of Tzénoff Equations for the Variable Mass Higher-Order Nonholonomic System

Institute of Scientific and Technical Information of China (English)

ZHENG Shi-Wang; WANG Jian-Bo; CHEN Xiang-Wei; XIE Jia-Fang

2012-01-01

Operational systems of spacecraft are general variable mass mechanics systems,and their symmetries and conserved quantities imply profound physical rules of the space system.We study the Mei symmetry of Tzénoff equations for a variable mass nonholonomic system and the new conserved quantities derived.The function expression of the new conserved quantities and the criterion equation which deduces these conserved quantities are presented.This result has some theoretical values in further research of conservation laws obeyed by the variable mass system.%Operational systems of spacecraft are general variable mass mechanics systems, and their symmetries and conserved quantities imply profound physical rules of the space system. We study the Mei symmetry of Tzenoff equations for a variable mass nonholonomic system and the new conserved quantities derived. The function expression of the new conserved quantities and the criterion equation which deduces these conserved quantities are presented. This result has some theoretical values in further research of conservation laws obeyed by the variable mass system.

Comportamiento meiótico de diferentes especies de lulo, Solanum sp Meiotic behavior of lulo species, Solanum sp

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Nancy Maricela Pareja Ordóñez

2010-10-01

Full Text Available Se realizó un análisis del comportamiento meiótico de las especies de lulo S. hirtum, S. quitoense y S. sessiliflorum, siguiendo la metodología convencional para los estudios de microsporogénesis. Se tomaron botones florales en diferentes estados de desarrollo, fijándolos por 24 horas en una solución de tres partes de etanol por una parte de ácido acético, saturada con trazas de cristales de cloruro férrico. Para la preparación de las placas se siguió la técnica de aplastamiento, se liberaron las células madres del grano de polen y finalmente se hicieron las observaciones bajo microscopía de luz. El análisis mostró que la meiosis se presenta en longitudes de antera que van desde los 2,79 mm hasta los 4,45 mm. La normalidad meiótica fue del 100%, tanto para meiosis I, como para la meiosis II. El índice meiótico en las tres especies fue del 99,98% lo cual indica que son buenos parentales y que pueden utilizarse en programas de cruzamiento. Las tres especies evaluadas tienen igual número de cromosomas (2n=2X=24. La frecuencia de anormalidades durante el proceso meiótico fue baja para S. hirtum, y alta para S. quitoense; sin embargo, la viabilidad polínica fue de gran magnitud (91,2-97,3%.An analysis of meiotic behavior of lulo species S. hirtum, S. quitoense and S. sessiliflorum, following the conventional methodology for studies of microsporogenesis was realized. Flower buds were taken at different stages of development, fixing them for 24 hours in a solution of three parts of ethanol per one part of acetic acid, saturated with traces of ferric chloride crystals. For the preparation of the slides following the technique of squash, releasing pollen mother cells and finally made the observations under light microscopy. The analysis showed that meiosis occurs in anther ranging from 2.79 to 4.45 mm. Meiotic normality was 100% for both meiosis I and II. The meiotic index in all three species was 99,98% indicating that they are

Los cromosomas meióticos de la rana arborícola Smilisca baudinii (Anura: Hylidae

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Javier Hernández-Guzmán

2011-03-01

Full Text Available La rana arborícola mexicana Smilisca baudinii, es una especie de rana común en Centroamérica. Sin embargo, la biología y genética de la especie, es pobremente conocida a pesar de su importancia para mantener en equilibrio ecológico las selvas tropicales. Con el propósito de contribuir con el conocimiento biológico de esta especie, establecimos el cariotipo típico en meiosis en especímenes recolectados en Tabasco, México, mediante procedimientos citogenéticos estándares. El estudio, se fundamentó en el análisis de 131 dispersiones cromosómicas en estadio meiótico de dos adultos de la especie (una hembra y un macho. El análisis de las metafases, permitió establecer el número modal haploide de 1n=12 cromosomas bivalentes. La fórmula cromosómica del cariotipo haploide, se integró por 12 cromosomas birrámeos caracterizado por 12 pares de cromosomas bivalentes metacéntricos-submetacéntricos (msm. Los conteos en meiosis, hacen suponer como número diploide de cromosomas a un complemento integrado por 2n=24 cromosomas birrámeos. No fue posible observar presencia de cromosomas sexuales, entre las dispersiones meióticas del espécimen hembra y macho. Los resultados sugieren que la estructura cromosómica de S. baudinii, es compartida ampliamente entre las especies de la familia Hylidae y los cromosomas "B" son estructuras importantes en la diversificación de las especies.

denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster

International Nuclear Information System (INIS)

Banga, S.S.; Boyd, J.B.; Valerie, K.; Harris, P.V.; Kurz, E.M.; de Riel, J.K.

1989-01-01

The denV gene of bacteriophage T4 was fused to a Drosophila hsp70 (70-kDa heat shock protein) promoter and introduced into the germ line of Drosophila by P-element-mediated transformation. The protein product of that gene (endonuclease V) was detected in extracts of heat-shocked transformants with both enzymological and immunoblotting procedures. That protein restores both excision repair and UV resistance to mei-9 and mus201 mutants of this organism. These results reveal that the denV gene can compensate for excision-repair defects in two very different eukayotic mutants, in that the mus201 mutants are typical of excision-deficient mutants in other organisms, whereas the mei-9 mutants exhibit a broad pleiotropism that includes a strong meiotic deficiency. This study permits an extension of the molecular analysis of DNA repair to the germ line of higher eukaryotes. It also provides a model system for future investigations of other well-characterized microbial repair genes on DNA damage in the germ line of this metazoan organism

A New type of conserved quantity deduced from Mei symmetry of nonholonomic systems in terms of quasi-coordinates

International Nuclear Information System (INIS)

Ting, Pang; Jian-Hui, Fang; Ming-Jiang, Zhang; Peng, Lin; Kai, Lu

2009-01-01

This paper studies the new type of conserved quantity which is directly induced by Mei symmetry of nonholonomic systems in terms of quasi-coordinates. A coordination function is introduced, and the conditions for the existence of the new conserved quantities as well as their forms are proposed. Some special cases are given to illustrate the generalized significance of the new type conserved quantity. Finally, an illustrated example is given to show the application of the nonholonomic system's results. (general)

The relationship between reaction kinetics and mutagenic action of monofunctional alkylating agents in higher eukaryotic systems. IV. The effects of the excision-defective mei-9L1 and mus(2)201D1 mutants on alkylation-induced genetic damage in Drosophila.

Science.gov (United States)

Vogel, E W; Dusenbery, R L; Smith, P D

1985-04-01

Repair-defective mutants of Drosophila melanogaster which identify two major DNA excision repair loci have been examined for their effects on alkylation-induced mutagenesis using the sex-linked recessive lethal assay as a measure of genotoxic endpoint. The alkylating agents (AAs) chosen for comparative analysis were selected on the basis of their reaction kinetics with DNA and included MMS, EMS, MNU, DMN, ENU, DEN and ENNG. Repair-proficient males were treated with the AAs and mated with either excision-defective mei-9L1 or mus(2)201D1 females or appropriate excision-proficient control females. The results of the present work suggest that a qualitative and quantitative relationship exists between the nature and the extent of chemical modification of DNA and the induction of of genetic alterations. The presence of either excision-defective mutant can enhance the frequency of mutation (hypermutability) and this hypermutability can be correlated with the Swain-Scott constant S of specific AAs such that as the SN1 character of the DNA alkylation reaction increases, the difference in response between repair-deficient and repair-proficient females decreases. The order of hypermutability of AAs with mei-9L1 relative to mei-9+ is MMS greater than MNU greater than DMN = EMS greater than iPMS = ENU = DEN = ENNG. When the percentage of lethal mutations induced in mei-9L1 females are plotted against those determined for control females, straight lines of different slopes are obtained. These mei-9L1/mei-9+ indices are: MMS = 7.6, MNU = 5.4, DMN = 2.4, EMS = 2.4 and iPMS = ENU = DEN = ENNG = 1. An identical order of hypermutability with similar indices is obtained for the mus(2)201 mutants: MMS(7.3) greater than MNU (5.4) greater than EMS(2.0) greater than ENU(1.1). Thus, absence of excision repair function has a significant effect on mutation production by AAs efficient in alkylating N-atoms in DNA but no measurable influence on mutation production by AAs most efficient in

Tales of Recombinant Femininity: "The Reincarnation of Golden Lotus," the "Chin P'ing Mei," and the Politics of Melodrama in Hong Kong.

Science.gov (United States)

Fore, Steve

1993-01-01

Examines the film "The Reincarnation of Golden Lotus" and the text upon which it is loosely based, the "Chin P'ing Mei," and the relationship between it and modern Chinese culture. States that the film's screenplay is much less an adaptation of the source novel than it is a female-centered reworking of a particular narrative…

76 FR 36951 - In the Matter of Shiming U.S., Inc., Si Mei Te Food Ltd. (f/k/a China Discovery Acquisition Corp...

Science.gov (United States)

2011-06-23

... Food Ltd. (f/k/a China Discovery Acquisition Corp.), Sierra International Group, Inc., and SJ... concerning the securities of Si Mei Te Food Ltd. (f/k/a China Discovery Acquisition Corp.) because it has not.... Therefore, it is ordered, pursuant to Section 12(k) of the Securities Exchange Act of 1934, that trading in...

Mei Symmetry and New Conserved Quantities of Tzénoff Equations for the Variable Mass Higher-Order Nonholonomic System

International Nuclear Information System (INIS)

Zheng Shi-Wang; Wang Jian-Bo; Chen Xiang-Wei; Xie Jia-Fang

2012-01-01

Operational systems of spacecraft are general variable mass mechanics systems, and their symmetries and conserved quantities imply profound physical rules of the space system. We study the Mei symmetry of Tzénoff equations for a variable mass nonholonomic system and the new conserved quantities derived. The function expression of the new conserved quantities and the criterion equation which deduces these conserved quantities are presented. This result has some theoretical values in further research of conservation laws obeyed by the variable mass system. (general)

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

International Nuclear Information System (INIS)

Dassé, E; Volpe, G; Walton, D S; Wilson, N; Del Pozzo, W; O'Neill, L P; Slany, R K; Frampton, J; Dumon, S

2012-01-01

The proto-oncogenic protein c-Myb is an essential regulator of hematopoiesis and is frequently deregulated in hematological diseases such as lymphoma and leukemia. To gain insight into the mechanisms underlying the aberrant expression of c-Myb in myeloid leukemia, we analyzed and compared c-myb gene transcriptional regulation using two cell lines modeling normal hematopoietic progenitor cells (HPCs) and transformed myelomonocytic blasts. We report that the transcription factors HoxA9, Meis1, Pbx1 and Pbx2 bind in vivo to the c-myb locus and maintain its expression through different mechanisms in HPCs and leukemic cells. Our analysis also points to a critical role for Pbx2 in deregulating c-myb expression in murine myeloid cells cotransformed by the cooperative activity of HoxA9 and Meis1. This effect is associated with an intronic positioning of epigenetic marks and RNA polymerase II binding in the orthologous region of a previously described alternative promoter for c-myb. Taken together, our results could provide a first hint to explain the abnormal expression of c-myb in leukemic cells

Drosophila mutations at the mei-9 and mus(2)201 loci which block excision of thymine dimers also block induction of unscheluded DNA synthesis by methyl methanesulfonate, ethyl methanesulfonate, N-methyl-N-nitrosourea, UV light and X-rays

International Nuclear Information System (INIS)

Dusenbery, R.L.; McCormick, S.C.; Smith, P.D.

1983-01-01

The mei-9 and mus(2)201 mutants of Drosophila melanogaster were identified as mutagen-sensitive mutants on the basis of larval hypersensitivity to methyl methanesulfonate and characterized as excision repair-deficient on the basis of a greatly reduced capacity to excise thymine dimers from cellular DNA. The high degree of larval cytotoxicity observed with a variety of other chemical and physical agents indicated that these mutants may be unable to excise other important classes of DNA adducts. We have measured the ability of the single mutants and the double mutant combination mei-9;mus(2)201 to perform the resynthesis step in excision repair by means of an autoradiographic analysis of unscheduled DNA synthesis (UDS) induced in a mixed population of primary cells in culture. The 3 strains exhibit no detectable UDS activity in response to applied doses of 1.5-6.0 mM methyl methanesulfonate, 1.0-4.5 nM N-methyl-N-nitrosourea or 10-40 J/m 2 254-nm UV light, dose ranges in which control cells exhibit a strong dose-dependent UDS response. The mei-9 and mei-9;mus(2)201 mutants also have no detectable UDS response to X-ray doses of 300-1.800 rad, whereas the mus(2)201 mutant exhibits a reduced, but dose-dependent, response over this range. These data correlate well with the degree of larval hypersensitivity of the strains and suggest that mutations at both loci block the excision repair of a wide variety of DNA damage prior to the resynthesis step. (orig.)

A case study on the impact of variable emission rates on the calculated MEI

Energy Technology Data Exchange (ETDEWEB)

Perry, R.A.; Chadbourne, J.

1994-12-31

When regulatory agencies require dispersion modeling to evaluate air quality impacts, the emissions modeled are the maximum allowable emissions. This requires an assumption that the source will constantly emit the maximum amount of each contaminant allowed by rule or by permit condition. For most sources, the actual emissions are typically much lower than the maximum allowed. Some years ago the Agency considered this issue through the ExEx policy to provide for specified {open_quotes}expected exceedances{close_quotes} while still meeting ambient standards. Emissions of Resource Conservation and Recovery Act (RCRA) metals from a cement kiln, using hazardous waste to replace fossil fuels, provides a useful example of the effect of variable emissions. The Boiler and Industrial Furnace (BIF) rule at 40 C.F.R. 266 subpart H specifies that allowable emission of arsenic, beryllium, cadmium, chromium, lead and thallium inter alia can be determined through dispersion modeling. Section 266.103(b)(v) specifies that the location of the most exposed individual (MEI) and dilution faction ({mu}g/m{sup 3} / g/sec) for the maximum annual average value must be determined. In addition, risk specific doses and reference air concentration (RSDs and RACs in {mu}g/m{sup 3}) are published in BIF appendix IV and V based on 70 years of exposure.

Fiscal 1998 overseas geological structure survey. Japan-China joint coal survey Mei-Xian project; 1998 nendo kaigai chishitsu kozo nado chosa hokokusho. Nippon Chugoku sekitan kyodo tansa Mei-Xian project

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Japan-China joint coal survey was made through seismic prospecting by Japanese group and drilling prospecting by Chinese group. Mei-Xian mine property includes coal seams of the Jurassic period, and is covered with the quaternary period stratum without any coal seam. The base of the quaternary period stratum exists at depth of 50-400m, while the coal seams at depth of 300-700m. Among 11 existing seams, the 1st and 5th seams are main objects for prospecting. The 5th seam of 0.2-8.96m (2.95m in average) thick is the most expected important one, distributing all over the mine property. The 5th seam also has branch seams spreading over 2.5km from east to west and 1.2km from south to north in the center part of the mine property. The 1st seam of 0-8.62m (2.90m in average) thick is most thick in the south part of the mine property. The theoretical amount of coal deposits in the whole coal seam is estimated to be nearly 290,000,000t by Chinese group (nearly 50% of it in the 5th seam). That is also estimated to be nearly 346,000,000t by Japanese group (155,000,000t in the 5th seam). Both 1st and 5th seams are composed of sub-bituminous coal. (NEDO)

Los cromosomas meióticos de la rana arborícola Smilisca baudinii (Anura: Hylidae

Directory of Open Access Journals (Sweden)

Javier Hernández-Guzmán

2011-03-01

Full Text Available La rana arborícola mexicana Smilisca baudinii, es una especie de rana común en Centroamérica. Sin embargo, la biología y genética de la especie, es pobremente conocida a pesar de su importancia para mantener en equilibrio ecológico las selvas tropicales. Con el propósito de contribuir con el conocimiento biológico de esta especie, establecimos el cariotipo típico en meiosis en especímenes recolectados en Tabasco, México, mediante procedimientos citogenéticos estándares. El estudio, se fundamentó en el análisis de 131 dispersiones cromosómicas en estadio meiótico de dos adultos de la especie (una hembra y un macho. El análisis de las metafases, permitió establecer el número modal haploide de 1n=12 cromosomas bivalentes. La fórmula cromosómica del cariotipo haploide, se integró por 12 cromosomas birrámeos caracterizado por 12 pares de cromosomas bivalentes metacéntricos-submetacéntricos (msm. Los conteos en meiosis, hacen suponer como número diploide de cromosomas a un complemento integrado por 2n=24 cromosomas birrámeos. No fue posible observar presencia de cromosomas sexuales, entre las dispersiones meióticas del espécimen hembra y macho. Los resultados sugieren que la estructura cromosómica de S. baudinii, es compartida ampliamente entre las especies de la familia Hylidae y los cromosomas "B" son estructuras importantes en la diversificación de las especies.Meiotic chromosomes of the tree frog Smilisca baudinii (Anura: Hylidae. The Mexican tree frog Smilisca baudinii, is a very common frog in Central America. In spite their importance to keep the ecological equilibrium of the rainforest, its biology and genetics are poorly known. In order to contribute with its biological knowledge, we described the typical meiotic karyotype based in standard cytogenetic protocols to specimens collected in Tabasco, Mexico. The study was centered in the analysis of 131 chromosome spreads at meiotic stage from two adults of the

Europees procesrecht en fundamentele procedurele vereisten: de rol van artikel 6 EVRM ter invulling van de openbare orde toets onder het EEX : Een beschouwing naar aanleiding van England and Wales Court of Appeal (Civil Division 29 mei 2002 (Maronier v. Larmer))

NARCIS (Netherlands)

X.E. Kramer (Xandra)

2004-01-01

textabstractIn deze bijdrage wordt een uitspraak van het Engelse Court of Appeal (Maronier v. Larmer, 29 mei 2002) geanalyseerd waarin de erkenning en tenuitvoerlegging van een Neder-lands vonnis wordt geweigerd op grond van strijd met de procedurele openbare orde in de zin van art. 27 sub 1

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

Science.gov (United States)

Calvo, K R; Knoepfler, P; McGrath, S; Kamps, M P

1999-12-23

The Pbx/Exd family of homeodomain (HD) proteins contribute to the transcriptional and developmental roles of other Hox and Meis/Prep1/Hth HD proteins through heterodimer formation. E2a-Pbx1 is an oncogenic derrivative of Pbx1 produced by the t(1;19) translocation in pediatric pre-B cell acute lymphoblastic leukemia. E2a-Pbx1 heterodimerizes with Hox but not with Meis/Prep1 proteins, produces acute myeloid leukemia in mice, and blocks differentiation of cultured murine myeloid progenitors. Here, we characterize negative and positive regulatory sequences that flank the Pbx1 HD and determine their importance for myeloid immortalization by E2a-Pbx1. A 25 residue predicted alpha helix preceding the Pbx1 HD bound the HD and prevented both its binding to DNA and its ability to heterodimerize with Hox proteins. Addition of 39 residues N-terminal to this inhibitory helix exposed a Pbx dimerization interface that orchestrated cooperative DNA-binding of E2a-Pbx1 and all Pbx proteins as homodimers and heterdimers. Sequences inhibiting DNA-binding and mediating Pbx dimerization coincided with those reported to have nuclear export function. An additional 103 residues N-terminal to the Pbx dimerization interface restored heterodimerization with Hox and Meis1/Prep1 proteins. This negative switch domain - comprised of the inhibitory helix and N-terminal regions required for its partner-mediated derepression - was dispensable for myeloid immortalization by E2a-Pbx1. While stabilizing the heterodimer, the 310 helix C-terminal to the Pbx1 HD was also dispensable for the ability of E2a-Pbx1 to heterodimerize with Hox proteins and immortalize myeloblasts. Retention of myeloid immortalization by E2a-Pbx1 proteins lacking all Pbx1 sequences N- or C-terminal to the HD indicates that Hox proteins, or a yet undefined factor that binds the Pbx1 HD and derepresses DNA-binding by the HD, cooperate with E2a-Pbx1 in myeloid immortalization.

Phylogenetic characterisation of circulating, clinical influenza isolates from Bali, Indonesia: preliminary report from the BaliMEI project.

Science.gov (United States)

Adisasmito, W; Budayanti, S N; Aisyah, D N; Gallo Cassarino, T; Rudge, J W; Watson, S J; Kozlakidis, Z; Smith, G J D; Coker, R

2017-08-23

Human influenza represents a major public health concern, especially in south-east Asia where the risk of emergence and spread of novel influenza viruses is particularly high. The BaliMEI study aims to conduct a five year active surveillance and characterisation of influenza viruses in Bali using an extensive network of participating healthcare facilities. Samples were collected during routine diagnostic treatment in healthcare facilities. In addition to standard clinical and molecular methods for influenza typing, next generation sequencing and subsequent de novo genome assembly were performed to investigate the phylogeny of the collected patient samples. The samples collected are characteristic of the seasonally circulating influenza viruses with indications of phylogenetic links to other samples characterised in neighbouring countries during the same time period. There were some strong phylogenetic links with sequences from samples collected in geographically proximal regions, with some of the samples from the same time-period resulting to small clusters at the tree-end points. However this work, which is the first of its kind completely performed within Indonesia, supports the view that the circulating seasonal influenza in Bali reflects the strains circulating in geographically neighbouring areas as would be expected to occur within a busy regional transit centre.

Análise invasiva e não invasiva do fuso meiótico de oócitos humanos obtidos de ciclos estimulados: dados preliminares Invasive and noninvasive analysis of the meiotic spindle of human oocytes obtained from stimulate cycles: preliminary results

Directory of Open Access Journals (Sweden)

Luciana Azôr Dib

2012-11-01

Full Text Available OBJETIVOS: Avaliar a concordância entre as técnicas de microscopia de polarização e microscopia confocal na avaliação do fuso meiótico de oócitos humanos maturados in vivo. MÉTODOS: Estudo prospectivo que avaliou oócitos com o primeiro corpúsculo polar extruído obtidos de mulheres inférteis submetidas à estimulação ovariana para realização de injeção intracitoplasmática de espermatozoide. Os oócitos com o primeiro corpúsculo polar extruído foram avaliados por meio da microscopia de polarização e, imediatamente após, foram fixados e corados para avaliação dos microtúbulos e cromatina pela microscopia confocal de alto desempenho. Foram comparadas as técnicas de microscopia de polarização e confocal, de acordo com a visualização ou não do fuso meiótico pela microscopia de polarização e a presença ou não de anomalias meióticas à análise pela microscopia confocal. Foram calculados os intervalos de confiança, o índice de Kappa e a concordância entre as metodologias, considerando a análise da microscopia de imunofluorescência como padrão-ouro para avaliação de normalidade do fuso e distribuição cromossômica oocitária. RESULTADOS: Observou-se que 72,7% dos oócitos em metáfase II com fuso celular não visível à polarização apresentaram anormalidades meióticas à análise confocal e que 55,6% dos oócitos em metáfase II com fuso celular visível à polarização apresentaram-se como oócitos anormais à análise confocal. Somente 44,4% dos oócitos com fuso celular visível à polarização apresentaram-se como normais à análise confocal. A concordância entre os métodos foi de 51,1% (Kappa: 0,11; IC95% -0,0958 - 0,319. CONCLUSÕES: A baixa concordância entre a microscopia de polarização e a confocal na avaliação do fuso meiótico oocitário sugere que a visualização do fuso meiótico de oócitos humanos em metáfase II pela microscopia de polarização tem limitado o valor

Meiotic analysis of the germoplasm of three medicinal species from Asteraceae family Análise meiótica do germoplasma de três espécies medicinais da família Asteraceae

Directory of Open Access Journals (Sweden)

Denise Olkoski

2008-09-01

Full Text Available Cytogenetic characterization was carried out on 12 accessions from Aster squamatus (Spreng. Hieron., Pterocaulon polystachyum DC, and Solidago microglossa DC by studying their meiotic behavior and pollen viability. These species are from the Asteraceae family, native to Rio Grande do Sul State, Brazil, and are important for medicinal use. Young inflorescences with four accessions of each species were collected, fixed in ethanol-acetic acid (3:1, and conserved in ethanol 70% until use. The method used was that of squashing the anthers and coloring with acetic orcein 2%. Meiosis was regular in all accessions, presenting chromosomal associations preferentially bivalent, where n=10 was found for Aster squamatus and n=9 for Pterocaulon polystachyum, and Solidago microglossa. The studied accessions presented a Meiotic Index (MI that varied from 65% to 87% in Aster squamatus, 85% to 92% in Pterocaulon polystachyum, and 64% to 92% in Solidago microglossa, indicating meiotic stability, although irregularities appeared during the cellular division. The pollen viability estimative was high in all studied accessions. These results indicate that the studied species can be included in future studies of genetic breeding.Foi realizada a caracterização citogenética de doze acessos de Aster squamatus, Pterocaulon polystachyum e Solidago microglossa, espécies da família Asteraceae, nativas do Rio Grande do Sul, Brasil, por meio do estudo do comportamento meiótico e da viabilidade polínica, que possuem grande importância para uso medicinal. Inflorescências jovens de quatro acessos de cada espécie foram fixadas em álcool-ácido acético (3:1 e conservadas em álcool 70% até o uso. O método utilizado foi o de esmagamento de anteras e a coloração com orceína acética 2%. A meiose foi regular em todos os acessos, apresentando associações cromossômicas preferencialmente em bivalentes, encontrando-se n=10 para Aster squamatus e n=9 para Pterocaulon

Abiks algajale jõuluvanale ئ millist muusikat kinkida / Mart Normet

Index Scriptorium Estoniae

Normet, Mart, 1979-

2005-01-01

Uutest heliplaatidest Eurythmics "Ultimate Collection", Belle & Sebastian "Push Barman To Open Old Wounds", Culture Club "Singles and Remixes", Bee Gees "Love Songs", Anastacia "Pieces Of A Draem", Ian Brown "The Greatest", Alanis Morissette "The Collection", Beastie Boys "Solid Gold Hits", Prodigy "Their Law", Celine Dion "On ne change pas", Bryan Adams "Anthology", Limp Bizkit "Greatest Hitz", Taj Mahal "The Essential Taj Mahal", Destiny's Child "#1'S", David Bowie "The Platinim Collection", John Lydon "The Best Of British", Dire Straits & Mark Knopfler "Private Investigations", Angie Stone "Stone Hits", Snoop Dogg "The Best Of Snoop Dogg"

NEKOLIKO TEMELJNIH DILEMA EKOLOŠKE ETIKE

OpenAIRE

Kirn, Andrej

1998-01-01

Odnos prirode i društva je taj koji izravno odre|uje mogućnost uspostave ekološke etike. Odnos prema prirodi u sebi uvijek uključuje odnos prema ljudima i obratno. »Učinkovito« korištenje prirode uvijek otpočinje s podre|ivanjem čovjeka čovjeku. Suvremeni procesi tehnološke i ekološke globalizacije ne ukidaju taj povijesni odnos izme|u čovjeka i prirode, već je uzdižu na novu razinu i daju novi oblik. Postoje tri velike povijesne društvenoekološke preobrazbe: paleolitska, neolitska i industri...

UV and gamma-ray sensitivity of meiosis-deficient mutants in Podospora anserina

International Nuclear Information System (INIS)

Simonet, J.M.

1976-01-01

Two mutants, mei1 and mei2, were isolated by screening for deficiencies occurring in the meiotic process. The sensitivity of mei1 and mei2 mutant strains to UV irradiation showed a significant increase as compared with that of the wild-type stock, hwhereas the sensitivity to γ-rays remained unchanged. The double-mutant strains were no more sensitive than each single mutant. The data indicate that both mei1 and mei2 loci are probably involved in the same pathway of excision-repair of UV-induced lesions

Noise-optimized virtual monoenergetic images and iodine maps for the detection of venous thrombosis in second-generation dual-energy CT (DECT): an ex vivo phantom study.

Science.gov (United States)

Bongers, Malte N; Schabel, Christoph; Krauss, Bernhard; Tsiflikas, Ilias; Ketelsen, Dominik; Mangold, Stefanie; Claussen, Claus D; Nikolaou, Konstantin; Thomas, Christoph

2015-06-01

Deep venous thrombosis (DVT) can be difficult to detect using CT due to poor and heterogeneous contrast. Dual-energy CT (DECT) allows iodine contrast optimization using noise-optimized monoenergetic extrapolations (MEIs) and iodine maps (IMs). Our aim was to assess whether MEI and IM could improve the delineation of thrombotic material within iodine-enhanced blood compared to single-energy CT (SECT). Six vessel phantoms, including human thrombus and contrast media-enhanced blood and one phantom without contrast, were placed in an attenuation phantom and scanned with DECT 100/140 kV and SECT 120 kV. IM, virtual non-contrast images (VNC), mixed images, and MEI were calculated. Attenuation of thrombi and blood were measured. Contrast and contrast-to-noise-ratios (CNRs) were calculated and compared among IM, VNC, mixed images, MEI, and SECT using paired t tests. MEI40keV and IM showed significantly higher contrast and CNR than SE120kV from high to intermediate iodine concentrations (contrast:pMEI40keV VNC images showed significantly higher contrast and CNR than SE120kV with inverted contrasts (contrast:pMEI190keV < 0.008,pVNC < 0.002;CNR:pMEI190keV < 0.003,pVNC < 0.002). Noise-optimized MEI and IM provide significantly higher contrast and CNR in the delineation of thrombosis compared to SECT, which may facilitate the detection of DVT in difficult cases. • Poor contrast makes it difficult to detect thrombosis in CT. • Dual-energy-CT allows contrast optimization using monoenergetic extrapolations (MEI) and iodine maps (IM). • Noise-optimized-MEI and IM are significantly superior to single-energy-CT in delineation of thrombosis. • Noise-optimized-MEI and IM may facilitate the detection of deep vein thrombosis.

Utilization during mitotic cell division of loci controlling meiotic recombination and disjunction in Drosophila melanogaster

International Nuclear Information System (INIS)

Baker, B.S.; Carpenter, A.T.C.; Ripoll, P.

1978-01-01

To inquire whether the loci identified by recombination-defective and disjunction-defective meiotic mutants in Drosophila are also utilized during mitotic cell division, the effects of 18 meiotic mutants (representing 13 loci) on mitotic chromosome stability have been examined genetically. To do this, meiotic-mutant-bearing flies heterozygous for recessive somatic cell markers were examined for the frequencies and types of spontaneous clones expressing the cell markers. In such flies, marked clones can arise via mitotic recombination, mutation, chromosome breakage, nondisjunction or chromosome loss, and clones from these different origins can be distinguished. In addition, meiotic mutants at nine loci have been examined for their effects on sensitivity to killing by uv and x rays. Mutants at six of the seven recombination-defective loci examined (mei-9, mei-41, c(3)G, mei-W68, mei-S282, mei-352, mei-218) cause mitotic chromosome instability in both sexes, whereas mutants at one locus (mei-218) do not affect mitotic chromosome stability. Thus many of the loci utilized during meiotic recombination also function in the chromosomal economy of mitotic cells

The Effect of a "Class Smoke Free Pledge" on Breath Carbon Monoxide in Arabic Male Adolescents.

Science.gov (United States)

Al-Sheyab, Nihaya A; Khader, Yousef S; Shah, Smita; Roydhouse, Jessica K; Gallagher, Robyn

2018-04-02

Arabic male adolescents have a high smoking prevalence. Introduction of "Class smoke-free" pledges have been successful amongst European adolescents but have not been evaluated using objective valid measures. We tested the impact of adding a smoke free pledge strategy to a proven peer-led asthma and smoking prevention program on breath carbon monoxide level (BCO) in male high-school students in Jordan. We enrolled male students from four high-schools in Irbid, Jordan. Schools were randomly assigned to receive either TAJ (Triple A in Jordan, n = 218) or TAJ-Plus (with added class smoke-free pledge, n = 215). We hypothesized that students receiving TAJ-Plus would have greater reduction in BCO levels than those only receiving the TAJ intervention. Asthma and smoking status were assessed by self-administered questionnaires. Smoking outcomes were collected using a BCO Monitor. Both groups had significant reductions in BCO levels post-intervention (p smoking status (p = .085), asthma status (p = .602), or a combination of the two (p = .702). An added smoke-free pledge strategy to a proven peer-led asthma education program appears to be a promising approach to motivate adolescents to abstain from smoking in Jordan. Future research is required to determine if these results can be extended to Jordanian adolescent females. A commitment by students via a "class smoke-free" pledge can be an added incentive to motivate adolescents in Arabic-speaking countries to abstain from smoking. Social influence approaches in schools can be useful in countering the aggressive tobacco marketing campaigns targeting Jordanian and other Arabic-speaking youth. The combination of "class smoke-free" pledges and an evidence-based peer-led asthma and smoking education can be implemented in schools to influence adolescents with asthma to abstain from smoking.

Noise-optimized virtual monoenergetic images and iodine maps for the detection of venous thrombosis in second-generation dual-energy CT (DECT): an ex vivo phantom study

International Nuclear Information System (INIS)

Bongers, Malte N.; Schabel, Christoph; Tsiflikas, Ilias; Ketelsen, Dominik; Mangold, Stefanie; Claussen, Claus D.; Nikolaou, Konstantin; Thomas, Christoph; Krauss, Bernhard

2015-01-01

Deep venous thrombosis (DVT) can be difficult to detect using CT due to poor and heterogeneous contrast. Dual-energy CT (DECT) allows iodine contrast optimization using noise-optimized monoenergetic extrapolations (MEIs) and iodine maps (IMs). Our aim was to assess whether MEI and IM could improve the delineation of thrombotic material within iodine-enhanced blood compared to single-energy CT (SECT). Six vessel phantoms, including human thrombus and contrast media-enhanced blood and one phantom without contrast, were placed in an attenuation phantom and scanned with DECT 100/140 kV and SECT 120 kV. IM, virtual non-contrast images (VNC), mixed images, and MEI were calculated. Attenuation of thrombi and blood were measured. Contrast and contrast-to-noise-ratios (CNRs) were calculated and compared among IM, VNC, mixed images, MEI, and SECT using paired t tests. MEI40keV and IM showed significantly higher contrast and CNR than SE120kV from high to intermediate iodine concentrations (contrast:pMEI40keV < 0.002,pIM < 0.005;CNR:pMEI40keV < 0.002,pIM < 0.004). At low iodine concentrations, MEI190keV and VNC images showed significantly higher contrast and CNR than SE120kV with inverted contrasts (contrast:pMEI190keV < 0.008,pVNC < 0.002;CNR:pMEI190keV < 0.003,pVNC < 0.002). Noise-optimized MEI and IM provide significantly higher contrast and CNR in the delineation of thrombosis compared to SECT, which may facilitate the detection of DVT in difficult cases. circle Poor contrast makes it difficult to detect thrombosis in CT. (orig.)

Noise-optimized virtual monoenergetic images and iodine maps for the detection of venous thrombosis in second-generation dual-energy CT (DECT): an ex vivo phantom study

Energy Technology Data Exchange (ETDEWEB)

Bongers, Malte N.; Schabel, Christoph; Tsiflikas, Ilias; Ketelsen, Dominik; Mangold, Stefanie; Claussen, Claus D.; Nikolaou, Konstantin; Thomas, Christoph [University Hospital of Tuebingen, Department of Diagnostic and Interventional Radiology, Tuebingen (Germany); Krauss, Bernhard [Siemens AG, Healthcare Sector, Forchheim (Germany)

2015-06-01

Deep venous thrombosis (DVT) can be difficult to detect using CT due to poor and heterogeneous contrast. Dual-energy CT (DECT) allows iodine contrast optimization using noise-optimized monoenergetic extrapolations (MEIs) and iodine maps (IMs). Our aim was to assess whether MEI and IM could improve the delineation of thrombotic material within iodine-enhanced blood compared to single-energy CT (SECT). Six vessel phantoms, including human thrombus and contrast media-enhanced blood and one phantom without contrast, were placed in an attenuation phantom and scanned with DECT 100/140 kV and SECT 120 kV. IM, virtual non-contrast images (VNC), mixed images, and MEI were calculated. Attenuation of thrombi and blood were measured. Contrast and contrast-to-noise-ratios (CNRs) were calculated and compared among IM, VNC, mixed images, MEI, and SECT using paired t tests. MEI40keV and IM showed significantly higher contrast and CNR than SE120kV from high to intermediate iodine concentrations (contrast:pMEI40keV < 0.002,pIM < 0.005;CNR:pMEI40keV < 0.002,pIM < 0.004). At low iodine concentrations, MEI190keV and VNC images showed significantly higher contrast and CNR than SE120kV with inverted contrasts (contrast:pMEI190keV < 0.008,pVNC < 0.002;CNR:pMEI190keV < 0.003,pVNC < 0.002). Noise-optimized MEI and IM provide significantly higher contrast and CNR in the delineation of thrombosis compared to SECT, which may facilitate the detection of DVT in difficult cases. circle Poor contrast makes it difficult to detect thrombosis in CT. (orig.)

ARCHAEOMAGNETIC STUDY OF THE EDIFICIO DE LAS COLUMNAS COMPLEX, EL TAJIN, MESOAMERICA (Estudio arqueomagnético del complejo del Edificio de las Columnas, El Tajín, Mesoamérica

Directory of Open Access Journals (Sweden)

Jaime Urrutia-Fucugauchi

2017-12-01

Full Text Available We report the initial results of an archaeomagnetic study on ceramic samples from the Edificio de las Columnas architectonic complex, located in the northern sector of El Tajin, an archaeological site. Measurements of magnetic properties include low-field susceptibility, direction and intensity of natural remanent magnetization, magnetic hysteresis, temperature-dependent susceptibility, isothermal remanent magnetization (IRM acquisition curves and back-field demagnetization of saturation IRM. We studied the vectorial composition and stability of remanent magnetization using alternating field and thermal demagnetization. Magnetic carriers are fine-grained titanomagnetites and magnetite with pseudo-single domain states. Characteristic magnetizations are determined from the high-temperature unblocking spectra. Determinants of paleointensity, which meet quality criteria, have high and low values. Possible explanations include alterations during thermal treatments and secondary overprints. The influence of alterations and the multivectorial magnetizations of overlapping spectra require detailed analysis to estimate the paleointensities. ESPAÑOL: Reportamos resultados del estudio arqueomagnético en muestras de cerámicas en el complejo arquitectónico del Edificio de las Columnas, localizado en el sector norte de El Tajín. Las mediciones de propiedades magnéticas incluyen susceptibilidad magnética, dirección e intensidad de la magnetización remanente natural, histéresis, variación de la susceptibilidad con temperatura, curvas de adquisición de magnetización isotermal y desmagnetización por campos directos de la magnetización isotermal de saturación. La composición vectorial y estabilidad de la magnetización remanente se investigaron por desmagnetización por campos magnéticos alternos y por temperatura. Las magnetizaciones muestran dos componentes que residen en titanomagnetitas y magnetita, con traslape en los espectros de

El complejo sinaptonémico en conejo cariotipo meiótico obtenido a partir de complejos sinaptonémicos en microesparcidos de espermatocitos paquiténicos

Directory of Open Access Journals (Sweden)

Juan José Filgueira D.

1986-10-01

Full Text Available Espermatocitos de conejo, fueron procesados mediante una técnica modificada de microesparcidos, que contribuyó a aumentar el conocimiento sobre el Complejo Sinaptonemico (CS y la sinapsis meiótica de los cromosomas del conejo. Los núcleos paquiténicos en microesparcidos, mostraron 22 Complejos inaptonémicos completamente formados que permitieron clasificarlos de acuerdo a la posición del centrómero; en los 22 grupos centroméricos, se determinaron las longitudes totales de los Complejos Sinaptonémicos, así como las correspondientes longitudes de los brazos de los bivalentes, para realizar un Idiograma. Los Complejos Sinaptonémicos (CS, aparecieron con restos de membrana nuclear en sus extremos y tres bivalentes presentaron residuos del nucleolo. El proceso de microesparcido fue seguido por microscopia óptica y se observe, como la técnica desarrollada para obtener los microesparcidos Hamada “de gota pendiente” aumentó la densidad de CSs por unidad de área. Las observaciones de los microesparcidos en grillas a traves del microscopio electrónico fueron corroboradas por observaciones de microesparcidos en placa, teñidos con plata, para microscopia de luz.

Accelerated degradation of methyl iodide by agrochemicals.

Science.gov (United States)

Zheng, Wei; Papiernik, Sharon K; Guo, Mingxin; Yates, Scott R

2003-01-29

The fumigant methyl iodide (MeI, iodomethane) is considered a promising alternative to methyl bromide (MeBr) for soil-borne pest control in high-cash-value crops. However, the high vapor pressure of MeI results in emissions of a significant proportion of the applied mass into the ambient air, and this may lead to pollution of the environment. Integrating the application of certain agrochemicals with soil fumigation provides a novel approach to reduce excessive fumigant emissions. This study investigated the potential for several agrochemicals that are commonly used in farming operations, including fertilizers and nitrification inhibitors, to transform MeI in aqueous solution. The pseudo-first-order hydrolysis half-life (t(1/2)) of MeI was approximately 108 d, while the transformation of MeI in aqueous solutions containing selected agrochemicals was more rapid, with t(1/2) agrochemicals on the rate of MeI degradation in soil was also determined. Adsorption to soil apparently reduced the availability of some nitrification inhibitors in the soil aqueous phase and lowered the degradation rate in soil. In contrast, addition of the nitrification inhibitors thiourea and allylthiourea to soil significantly accelerated the degradation of MeI, possibly due to soil surface catalysis. The t(1/2) of MeI was 300 h).

Meiotic UV-sensitive mutant that causes deletion of duplications in neurospora

International Nuclear Information System (INIS)

Newmeyer, D.; Galeazzi, D.R.

1978-01-01

The meiotic-3 (mei-3) mutant of Neurospora crassa has several effects: (1) when homozygous, it almost completely blocks meiosis and ascospore formation, (2) it is sensitive to uv, (3) its growth is inhibited by histidine, and (4) it increases the instability of nontandem duplications. This was shown for duplications produced by five different rearrangements and was demonstrated by two different criteria. The effects on meiosis and duplication instability are expressed strongly at 25 0 ; the effects on sensitivity to uv and to histidine are expressed strongly at 38.5 0 but only slightly at 25 0 . Nevertheless, all four effects were shown to be due to a single gene. Mei-3 is not allelic with previously reported uv-sensitive mutants. Two other results were obtained that are not necessarily due to mei-3: (1) a cross involving mei-3 produced a new unlinked meiotic mutant, mei-4, which is not sensitive to uv or histidine, and (2) a burst of several new mutants occurred in a different mei-3 stock, including a partial revertant to mei-3. Mei-3 has previously been shown to cause frequent complete loss of a terminal duplicate segment, beginning exactly at the original rearrangement breakpoint. Possible mechanisms are discussed by which a uv-sensitive mutant could cause such precise deletions

Electron stimulated reactions of methyl iodide coadsorbed with amorphous solid water

International Nuclear Information System (INIS)

Perry, C. C.; Faradzhev, N. S.; Madey, T. E.; Fairbrother, D. H.

2007-01-01

The electron stimulated reactions of methyl iodide (MeI) adsorbed on and suspended within amorphous solid water (ice) were studied using a combination of postirradiation temperature programmed desorption and reflection absorption infrared spectroscopy. For MeI adsorbed on top of amorphous solid water (ice), electron beam irradiation is responsible for both structural and chemical transformations within the overlayer. Electron stimulated reactions of MeI result principally in the formation of methyl radicals and solvated iodide anions. The cross section for electron stimulated decomposition of MeI is comparable to the gas phase value and is only weakly dependent upon the local environment. For both adsorbed MeI and suspended MeI, reactions of methyl radicals within MeI clusters lead to the formation of ethane, ethyl iodide, and diiodomethane. In contrast, reactions between the products of methyl iodide and water dissociation are responsible for the formation of methanol and carbon dioxide. Methane, formed as a result of reactions between methyl radicals and either parent MeI molecules or hydrogen atoms, is also observed. The product distribution is found to depend on the film's initial chemical composition as well as the electron fluence. Results from this study highlight the similarities in the carbon-containing products formed when monohalomethanes coadsorbed with amorphous solid water are irradiated by either electrons or photons

78 FR 70615 - Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and...

Science.gov (United States)

2013-11-26

.... The MEI Port includes access to MIAX's primary and secondary data centers and its disaster recovery... Port includes access to MIAX's primary and secondary data centers and its disaster recovery center. \\6... Service MEI Ports to Market Makers. Currently, MIAX assesses monthly MEI Port Fees on Market Makers based...

75 FR 17396 - Notice of Availability of Government-Owned Inventions; Available for Licensing

Science.gov (United States)

2010-04-06

... diagnostics and therapeutics for scrub typhus and HIV infections'', Inventors: Wei Mei Ching, Chien Chung Chao... orientia tsutsugamushi to be used as a vaccine component against scrub typhus'', Inventors: Wei Mei Ching..., ``Recombinant antigens for diagnosis and prevention of murine typhus'', Inventor: Wei Mei Ching, issued June 9...

Caramel color in soft drinks and exposure to 4-methylimidazole: a quantitative risk assessment.

Directory of Open Access Journals (Sweden)

Tyler J S Smith

Full Text Available Caramel color is added to many widely-consumed beverages as a colorant. Consumers of these beverages can be exposed to 4-methylimidazole (4-MEI, a potential carcinogen formed during its manufacture. California's Proposition 65 law requires that beverages containing 4-MEI concentrations corresponding to exposures that pose excess cancer risks > 1 case per 100,000 exposed persons (29 μg 4-MEI/day carry warning labels. Using ultrahigh-performance liquid chromatography-tandem mass spectrometry, we assessed 4-MEI concentrations in 12 beverages purchased in California and a geographically distant metropolitan area (New York in which warning labels are not required. In addition, we characterized beverage consumption by age and race/ethnicity (using weighted means calculated from logistic regressions and assessed 4-MEI exposure and resulting cancer risks and US population cancer burdens attributable to beverage consumption. Data on beverage consumption were obtained from the National Health and Nutrition Examination Survey, dose-response data for 4-MEI were obtained from the California Environmental Protection Agency Office of Environmental Health Hazards Assessment, and data on population characteristics were obtained from the U.S. Census Bureau. Of the 12 beverages, Malta Goya had the highest 4-MEI concentration (915.8 to 963.3μg/L, lifetime average daily dose (LADD - 8.04x10-3 mg/kgBW-day, lifetime excess cancer risk (1.93x10-4 and burden (5,011 cancer cases in the U.S. population over 70 years; Coca-Cola had the lowest value of each (4-MEI: 9.5 to 11.7μg/L; LADD: 1.01x10-4 mg/kgBW-day; risk: 1.92x10-6; and burden: 76 cases. 4-MEI concentrations varied considerably by soda and state/area of purchase, but were generally consistent across lots of the same beverage purchased in the same state/area. Routine consumption of certain beverages can result in 4-MEI exposures > 29 μg/day. State regulatory standards appear to have been effective in reducing

Caramel color in soft drinks and exposure to 4-methylimidazole: a quantitative risk assessment.

Science.gov (United States)

Smith, Tyler J S; Wolfson, Julia A; Jiao, Ding; Crupain, Michael J; Rangan, Urvashi; Sapkota, Amir; Bleich, Sara N; Nachman, Keeve E

2015-01-01

Caramel color is added to many widely-consumed beverages as a colorant. Consumers of these beverages can be exposed to 4-methylimidazole (4-MEI), a potential carcinogen formed during its manufacture. California's Proposition 65 law requires that beverages containing 4-MEI concentrations corresponding to exposures that pose excess cancer risks > 1 case per 100,000 exposed persons (29 μg 4-MEI/day) carry warning labels. Using ultrahigh-performance liquid chromatography-tandem mass spectrometry, we assessed 4-MEI concentrations in 12 beverages purchased in California and a geographically distant metropolitan area (New York) in which warning labels are not required. In addition, we characterized beverage consumption by age and race/ethnicity (using weighted means calculated from logistic regressions) and assessed 4-MEI exposure and resulting cancer risks and US population cancer burdens attributable to beverage consumption. Data on beverage consumption were obtained from the National Health and Nutrition Examination Survey, dose-response data for 4-MEI were obtained from the California Environmental Protection Agency Office of Environmental Health Hazards Assessment, and data on population characteristics were obtained from the U.S. Census Bureau. Of the 12 beverages, Malta Goya had the highest 4-MEI concentration (915.8 to 963.3μg/L), lifetime average daily dose (LADD - 8.04x10-3 mg/kgBW-day), lifetime excess cancer risk (1.93x10-4) and burden (5,011 cancer cases in the U.S. population over 70 years); Coca-Cola had the lowest value of each (4-MEI: 9.5 to 11.7μg/L; LADD: 1.01x10-4 mg/kgBW-day; risk: 1.92x10-6; and burden: 76 cases). 4-MEI concentrations varied considerably by soda and state/area of purchase, but were generally consistent across lots of the same beverage purchased in the same state/area. Routine consumption of certain beverages can result in 4-MEI exposures > 29 μg/day. State regulatory standards appear to have been effective in reducing exposure to

Caramel Color in Soft Drinks and Exposure to 4-Methylimidazole: A Quantitative Risk Assessment

Science.gov (United States)

Smith, Tyler J. S.; Wolfson, Julia A.; Jiao, Ding; Crupain, Michael J.; Rangan, Urvashi; Sapkota, Amir; Bleich, Sara N.; Nachman, Keeve E.

2015-01-01

Caramel color is added to many widely-consumed beverages as a colorant. Consumers of these beverages can be exposed to 4-methylimidazole (4-MEI), a potential carcinogen formed during its manufacture. California’s Proposition 65 law requires that beverages containing 4-MEI concentrations corresponding to exposures that pose excess cancer risks > 1 case per 100,000 exposed persons (29 μg 4-MEI/day) carry warning labels. Using ultrahigh-performance liquid chromatography-tandem mass spectrometry, we assessed 4-MEI concentrations in 12 beverages purchased in California and a geographically distant metropolitan area (New York) in which warning labels are not required. In addition, we characterized beverage consumption by age and race/ethnicity (using weighted means calculated from logistic regressions) and assessed 4-MEI exposure and resulting cancer risks and US population cancer burdens attributable to beverage consumption. Data on beverage consumption were obtained from the National Health and Nutrition Examination Survey, dose-response data for 4-MEI were obtained from the California Environmental Protection Agency Office of Environmental Health Hazards Assessment, and data on population characteristics were obtained from the U.S. Census Bureau. Of the 12 beverages, Malta Goya had the highest 4-MEI concentration (915.8 to 963.3μg/L), lifetime average daily dose (LADD - 8.04x10-3 mg/kgBW-day), lifetime excess cancer risk (1.93x10-4) and burden (5,011 cancer cases in the U.S. population over 70 years); Coca-Cola had the lowest value of each (4-MEI: 9.5 to 11.7μg/L; LADD: 1.01x10-4 mg/kgBW-day; risk: 1.92x10-6; and burden: 76 cases). 4-MEI concentrations varied considerably by soda and state/area of purchase, but were generally consistent across lots of the same beverage purchased in the same state/area. Routine consumption of certain beverages can result in 4-MEI exposures > 29 μg/day. State regulatory standards appear to have been effective in reducing exposure

Compaction and Collapse Characteristics of Dune Sand Stabilized with Lime-Silica Fume Mix

Directory of Open Access Journals (Sweden)

Mohammed Y. Fattah

2016-04-01

Full Text Available The purpose of this research is to assess the suitability of dune sands as construction materials. Moreover, such a goal is considered beneficial in determining appropriate methods for soil stabilization or ground improvement and to assessing the suitability of dune sands as subgrade layer for carrying roads and rail foundation. Dune sand samples were collected from a region in Baiji area in Salah-Aldeen governorate, North of Iraq. A grey-colored densified silica fume (SF and lime (L are used. Three percentages are used for lime (3%, 6%, and 9%, and four rates are used for silica fume (3%, 6%, 9% and 12% and the maximum percentage of silica fume is mixed with the proportions of lime. Unsoaked California Bearing Ratio (CBR on compacted dune sands treated dune sands with L-SF by mixing and cured for one day. The increasing in CBR ranged between 443 – 707% at 2.54 mm penetration and 345 – 410% at 5.08 mm penetration.     Resumen El propósito de esta investigación es evaluar el uso de arena de dunas como materiales de construcción. Además, este objetivo permite determinar los métodos apropiados para la estabilización del suelo, el mejoramiento del terreno y la evaluación de pertinencia de la arena de dunas en capas subbase para carreteras y cimientos férreos. Se recolectaron muestras de arena de dunas en el área de Baiji, del comisionado Salah-Aldeen, al norte de Irak. Se utilizó vapor de óxido de silicio (SF, en inglés, grisáceo y densificado, y óxido de calcio (L. Se utilizaron tres porcentajes para el óxido de calcio (3 %, 6 % y 9 %, y cuatro para el óxido de silicio (3 %, 6 %,  9% y 12% y el máximo porcentaje del óxido de silicio se mezcló con las proporciones de óxido de calcio. Se realizó en seco el Ensayo de Relación de Soporte de California (del inglés California Bearing Ratio, CBR en arena de dunas compactada y tratada con la mezcla L-SF curada durante un día. El incremento en el ensayo CBR osciló entre 443

Popmuusika / Mart Juur

Index Scriptorium Estoniae

Juur, Mart, 1964-

2006-01-01

Uutest heliplaatidest Kent "Du & Jag", "Lindstom & Prins Thomas", Taj Mahal "The Essential", Wilco "Kicking elevision - Live In Chicago", Yo-Yo Ma "The Essential", Bob marley & The Wailers "Africa Unite: The Singles", Nine Horses "Snow Borne Sorrow"

Process-induced formation of imidazoles in selected foods.

Science.gov (United States)

Mottier, Pascal; Mujahid, Claudia; Tarres, Adrienne; Bessaire, Thomas; Stadler, Richard H

2017-08-01

The presence of 4-methylimidazole (4-MEI), 2-methylimidazole (2-MEI) and 2-acetyl-4-tetrahydroxybutylimidazole (THI) in some foods may result from the usage of caramel colorants E150c and E150d as food additives. This study demonstrates that alkylimidazoles are also byproducts formed from natural constituents in foods during thermal processes. A range of heat-processed foods that are known not to contain caramel colorants were analyzed by isotope dilution LC-MS/MS to determine the contamination levels. Highest 4-MEI concentrations (up to 466µg/kg) were observed in roasted barley, roasted malt and cocoa powders, with the concomitant presence of 2-MEI and/or THI in some cases, albeit at significantly lower levels. Low amounts of 4-MEI (foods such as breakfast cereals and bread toasted to a brown color (medium toasted). The occurrence of 4-MEI in certain processed foods is therefore not a reliable indicator of the presence of the additives E150c or E150d. Copyright © 2017 Elsevier Ltd. All rights reserved.

Prakses kopienas dažādie aspekti: Etnogrāfisks pētījums par coworking kopienu Rīgā

OpenAIRE

Zālīte, Zanda

2015-01-01

Šajā pētījumā ar etnogrāfisku metožu palīdzību tiek izzināts, kā kļūšana par coworking kopienas locekli ietekmē pašnodarbināto darba pieredzi un identitāti, kā arī, kā kopienas veidošanās pētītajā coworking vietā ietekmē coworking praksi. Pētītajā coworking vietā tiek veicināta kopienas izveide, kuras rezultātā pašnodarbinātie veido profesionālas sadarbības, dalās zināšanās un mācās viens no otra. Kopienas sniegtais atbalsts rada iespēju pašnodarbinātajiem pretoties nevēlamām subjekta pozīcij...

Džuče ideoloģijas attīstība un tās ietekme Ziemeļkorejas ārpolitikā (2011-2016)

OpenAIRE

Šķestere, Ildze

2017-01-01

Šī bakalaura darba nosaukums ir “Džuče ideoloģijas attīstība un tās ietekme Ziemeļkorejas ārpolitikā (2011-2016)”. Mūsdienās Ziemeļkorejas ārpolitika ir īpaši svarīga austrumāzijas reģionā, tāpēc šajā darbā tiek aplūkots viens no iespējamajiem ietekmējošajiem faktoriem tajā – džuče ideoloģija.Uzsvars šajā darbāir likts uz ideoloģijas vēsturi un tās pamatelementiem, kā arī tajā tiek pielietota detalizētāk pieeja apskatot kā katrs no Ziemeļkorejas līderiem to paplašināja. Sākot no Kim Il Song, ...

Cloning of a postreplication repair gene in Drosophila

International Nuclear Information System (INIS)

Banga, S.S.; Yamamoto, A.H.; Mason, J.M.; Boyd, J.B.

1987-01-01

Mutants at the mei-41 locus in Drosophila are strongly hypersensitive to each of eight tested mutagens. Mutant flies exhibit reduced meiotic recombination and elevated levels of chromosomal aberrations. In analogy with the defect in xeroderma pigmentosum variant cells, mei-41 cells are strongly defective in postreplication repair following UV radiation. In preparation for cloning that gene they have performed complementation studies between chromosomal aberrations and mei-41 mutants. That study has localized the mei-41 gene to polytene chromosome bands 14C4-6. A chromosomal walk conducted in that region has recovered about 65 kb of contiguous DNA sequence. The position of the mei-41 gene within that region has been established with the aid of a mutation in that gene which was generated by the insertion of a transposable element. Transcription mapping is being employed to define the complete coding region of the gene in preparation for investigations of gene function

A mindful eating intervention: A theory-guided randomized anti-obesity feasibility study with adolescent Latino females.

Science.gov (United States)

Daly, Patricia; Pace, Thaddeus; Berg, Judith; Menon, Usha; Szalacha, Laura A

2016-10-01

While pediatric anti-obesity lifestyle interventions have received considerable attention, few show sustained impact on body mass index (BMI). Using the Information-Motivation-Behavioral Skills Theory as a framework, we examined the effects of a satiety-focused mindful eating intervention (MEI) on BMI, weight and mindful awareness. Utilizing a two-group, repeated measures design, 37 adolescent females with a BMI >90th percentile, recruited from a public high school in a Latino community in the Southwestern United States, were randomized 2:1, one third to the group receiving a 6-week MEI and two thirds to the comparison group (CG) receiving the usual care (nutrition and exercise information). During six weekly 90-min after school MEI group sessions, the behavioral skills of slow intentional eating were practiced with foci on satiety cues and triggers to overeat. Feasibility and acceptability were measured as participant retention (goal ≥55%) and evaluative comments from those in the MEI group, respectively. BMI and mindful awareness were measured on site at baseline, immediately post intervention, and at 4-week follow-up (week 10). Fifty-seven and 65% of those in the MEI and CG were retained throughout the study, respectively. MEI participants showed significantly lowered BMI compared with CG participants, whose weight increased (p90th percentile standard growth projections). Initial and sustained decline of BMI in the MEI group supports further study of this theory-guided approach, and the value of practicing satiety-focused mindful eating behavioral skills to facilitate health behavior change. Copyright © 2016 Elsevier Ltd. All rights reserved.

Studies of the repair of radiation-induced genetic damage in Drosophila Annual progress report, 1 November 1994 - 1 January 1996

International Nuclear Information System (INIS)

Hawley, R.S.

1996-01-01

The authors have recently cloned the mei-4l gene, and showed that its putative translation product is highly homologous to the ATM, MEC1, and RAD3 genes at the level of primary amino acid sequence. That this sequence similarity reflects a functional homology is suggested by three lines of evidence: (1) as is the case for the ATM gene, loss of function of mei-4l results in increased sensitivity to X-irradiation; (2) mutations in the mei-4l gene also resemble ATM mutations in that they cause high levels of chromosome breakage and genetic instability; and (3) like the ATM gene, the wild-type MEI-4l protein also plays a role in mediating the progression of the cell cycle

Spinal dual-energy computed tomography: improved visualisation of spinal tumorous growth with a noise-optimised advanced monoenergetic post-processing algorithm

Energy Technology Data Exchange (ETDEWEB)

Kraus, Mareen; Weiss, Jakob; Selo, Nadja; Notohamiprodjo, Mike; Bamberg, Fabian; Nikolaou, Konstantin; Othman, Ahmed E. [Eberhard Karls University Tuebingen, Department of Diagnostic and Interventional Radiology, Tuebingen (Germany); Flohr, Thomas [Siemens Healthcare GmbH, Erlangen (Germany)

2016-11-15

The aim of this study was to evaluate the effect of advanced monoenergetic post-processing (MEI+) on the visualisation of spinal growth in contrast-enhanced dual-energy CT (DE-CT). Twenty-six oncologic patients (age, 61 ± 17 years) with spinal tumorous growth were included. Patients underwent contrast-enhanced dual-energy CT on a third-generation dual-source CT scanner. Image acquisition was in dual-energy mode (100/Sn150kV), and scans were initiated 90 s after contrast agent administration. Virtual monoenergetic images (MEI+) were reconstructed at four different kiloelectron volts (keV) levels (40, 60, 80, 100) and compared to the standard blended portal venous computed tomography (CT{sub pv}). Image quality was assessed qualitatively (conspicuity, delineation, sharpness, noise, confidence; two independent readers; 5-point Likert scale; 5 = excellent) and quantitatively by calculating signal-to-noise (SNR) and contrast-to-noise-ratios (CNR). For a subgroup of 10 patients with MR imaging within 4 months of the DE-CT, we compared the monoenergetic images to the MRIs qualitatively. Highest contrast of spinal growth was observed in MEI+ at 40 keV, with significant differences to CT{sub pv} and all other keV reconstructions (60, 80, 100; p < 0.01). Highest conspicuity, delineation and sharpness were observed in MEI+ at 40 keV, with significant differences to CT{sub pv} (p < 0.001). Similarly, MEI+ at 40 keV yielded highest diagnostic confidence (4.6 ± 0.6), also with significant differences to CT{sub pv} (3.45 ± 0.9, p < 0.001) and to high keV reconstructions (80, 100; p ≤ 0.001). Similarly, CNR calculations revealed highest scores for MEI+ at 40 keV followed by 60 keV and CT{sub pv}, with significant differences to high keV MEI+ reconstructions. Qualitative analysis scores peaked for MR images followed by the MEI+ 40-keV reconstructions. MEI+ at low keV levels can significantly improve image quality and delineation of spinal growth in patients with portal

Genomic Instability and Breast Cancer

Science.gov (United States)

2011-06-01

distinguish these possibilities. The possible function of human SWI5-MEI5 in meiosis also needs to be investigated. It remains to be determined whether the... human SWI5-MEI5 complex acts in meiosis and, if it does, whether it acts with DMC1, RAD51, or both. Considering that SWI5-MEI5 is the only human ...tumorigenesis. This has been clearly illustrated in familial breast cancer, since human genetic studies reveal that many genes involved in DNA damage response

Militarized Maneuver Terrorism

Science.gov (United States)

2015-06-12

striking the heart of the Indian tourism market and creating a siege in the Taj Mahal, it was certain to create a theater of terror. A drama played out... sport facilities, malls, movie theaters, and more. Grossman argues that American society has put forth enormous effort preparing and preventing harm to

Improving Tools for JavaScript Programmers (Position Paper)

DEFF Research Database (Denmark)

Andreasen, Esben; Feldthaus, Asger; Jensen, Simon Holm

We present an overview of three research projects that all aim to provide better tools for JavaScript web application programmers1: TAJS, which infers static type information for JavaScript applications using dataflow analysis; JSRefac- tor, which enables sound code refactorings; and Artemis, which...... provides high-coverage automated testing....

Molecular Evolution at a Meiosis Gene Mediates Species Differences in the Rate and Patterning of Recombination.

Science.gov (United States)

Brand, Cara L; Cattani, M Victoria; Kingan, Sarah B; Landeen, Emily L; Presgraves, Daven C

2018-04-23

Crossing over between homologous chromosomes during meiosis repairs programmed DNA double-strand breaks, ensures proper segregation at meiosis I [1], shapes the genomic distribution of nucleotide variability in populations, and enhances the efficacy of natural selection among genetically linked sites [2]. Between closely related Drosophila species, large differences exist in the rate and chromosomal distribution of crossing over. Little, however, is known about the molecular genetic changes or population genetic forces that mediate evolved differences in recombination between species [3, 4]. Here, we show that a meiosis gene with a history of rapid evolution acts as a trans-acting modifier of species differences in crossing over. In transgenic flies, the dicistronic gene, mei-217/mei-218, recapitulates a large part of the species differences in the rate and chromosomal distribution of crossing over. These phenotypic differences appear to result from changes in protein sequence not gene expression. Our population genetics analyses show that the protein-coding sequence of mei-218, but not mei-217, has a history of recurrent positive natural selection. By modulating the intensity of centromeric and telomeric suppression of crossing over, evolution at mei-217/-218 has incidentally shaped gross differences in the chromosomal distribution of nucleotide variability between species. We speculate that recurrent bouts of adaptive evolution at mei-217/-218 might reflect a history of coevolution with selfish genetic elements. Copyright © 2018 Elsevier Ltd. All rights reserved.

Carotid dual-energy CT angiography: Evaluation of low keV calculated monoenergetic datasets by means of a frequency-split approach for noise reduction at low keV levels.

Science.gov (United States)

Riffel, Philipp; Haubenreisser, Holger; Meyer, Mathias; Sudarski, Sonja; Morelli, John N; Schmidt, Bernhard; Schoenberg, Stefan O; Henzler, Thomas

2016-04-01

Calculated monoenergetic ultra-low keV datasets did not lead to improved contrast-to-noise ratio (CNR) due to the dramatic increase in image noise. The aim of the present study was to evaluate the objective image quality of ultra-low keV monoenergetic images (MEIs) calculated from carotid DECT angiography data with a new monoenergetic imaging algorithm using a frequency-split technique. 20 patients (12 male; mean age 53±17 years) were retrospectively analyzed. MEIs from 40 to 120 keV were reconstructed using the monoenergetic split frequency approach (MFSA). Additionally MEIs were reconstructed for 40 and 50 keV using a conventional monoenergetic (CM) software application. Signal intensity, noise, signal-to-noise ratio (SNR) and CNR were assessed in the basilar, common, internal carotid arteries. Ultra-low keV MEIs at 40 keV and 50 keV demonstrated highest vessel attenuation, significantly greater than those of the polyenergetic images (PEI) (all p-values 0.05). Thus MEIs with MFSA showed significantly higher SNR and CNR compared to MEIs with CM. Combining the lower spatial frequency stack for contrast at low keV levels with the high spatial frequency stack for noise at high keV levels (frequency-split technique) leads to improved image quality of ultra-low keV monoenergetic DECT datasets when compared to previous monoenergetic reconstruction techniques without the frequency-split technique. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Relationships between tuna catch and variable frequency oceanographic conditions

Directory of Open Access Journals (Sweden)

F. I. Ormaza-González

2016-08-01

Full Text Available Skipjack (Katsuwunus pelamis, yellow fin (Thunnus albacares and albacore (Thunnus alulunga tunas landed in the Eastern Pacific Ocean (EPO countries and Ecuador were correlated to the Indexes Oceanic El Niño (ONI and Multivariate Enso Index (MEI. The temporal series 1983–2012, and 1977–1999 (warm Pacific Decadal Oscillation, PDO, and 2000–2012 (cold PDO were analyzed. Linear correlation showed that at least 11 % of the total landings were associated with the MEI, with a slightly negative gradient from cold to warm conditions. When non-linear regression (n  =  6, the R2 was higher up to 0.304 (MEI, r =  0.551. The correlation shows high spread from −0.5 to +0.5 for both MEI/ONI; the highest landings occurred at 0.34–0.45; both indexes suggested that at extreme values < −1.0 and > 1.1 total landings tend to decrease. Landings were associated up to 21.9 % (MEI in 2000–2012, 1983–1999 rendered lower R2 (< 0.09; i.e., during cold PDO periods there was a higher association between landings and oceanographic conditions. For the non-linear regression (n  =  6 a R2 of 0.374 (MEI and 0.408 (ONI were registered, for the 2000–2012, a higher R2 was observed in 1983–1999, 0.443 and 0.711 for MEI and ONI respectively, suggesting that is better to analyze split series (1983–1999, 2000–2012 than as a whole (1983–2012, due to noise produced by the transition from hot to cold PDOs. The highest landings were in the range −0.2 to 0.5 for MEI/ONI. The linear regression of skipjack landings in Ecuador gave an R2 of 0.140 (MEI and 0.066 (ONI and the non-linear were 0.440 and 0.183 respectively. Total landings in the EPO associated to oceanographic events of high and low frequencies could be used somehow as predictors of the high El Niño o La Niña. There is a clear evidence that tuna fish biomass are at higher levels when the PDO is on cold phase (2000–2030 and vice versa on warm phase (1980–1999. The

NFAT Signaling and the Tumorigenic Microenvironment of the Prostate

Science.gov (United States)

2015-10-01

25038189; PMCID: PMC4166785. Status of publication: published; acknowledgement of federal support: Yes. (4) Fuqiang Ren, Mingyu Fan, Jiandong Mei...support: Yes. (3) Fuqiang Ren, Mingyu Fan, Jiandong Mei, Yongqiang Wu, Chengwu Liu, Qiang Pu, Zongbing You*, and Lunxu Liu*. Interferon-γ and

Convergence: Special Operations Forces and Civilian Law Enforcement

Science.gov (United States)

2010-07-01

Hospital, the Metro Cinema , St. Xavier’s College, the Orthodox Jewish-own Nariman House, the Leopold Café, and two hotels: the Taj Mahal Palace and the...perspective, and remembering the magnitude of World War II, of 21 Germans tried at Nuernberg, only 11 were sentenced to death. Of the 25 Japanese tried, 7

Four Questions

Science.gov (United States)

Hark-Weber, Amara G., Ed.

2013-01-01

The author is pleased to introduce a new section in "TAJ," Four Questions. The structure is simple: four questions are asked to teaching artists working in various media and locations. The questions are always the same, but because each teaching artist's approach is unique, their answers will provide an insight into particular methodologies that…

A few words of delight

Directory of Open Access Journals (Sweden)

Hamp Eric P.

2005-01-01

Full Text Available Lith. lokšniis "tender, etc" is traced back, by way of dissimilation, to *losk-snii-, derived with the adjectival suffix -snii-, productive in Baltic, from the I.-E. stem of Slavic laska, Lat. lasc-tvus, etc. In the second part of the paper the autor pleads for distinguishing, in Slavic between tgg'' "peace" = OLith. mieras, Latv. miers < Balto-Slavic *mei-ro "pleasure, leisure", akin to *mei-lo- "agreeable, kind", and tlg'' "κόσμος" < *"binding, linkage", to I.-E. *mei- "bind, link" in Skt. mitra- "friend" Avest. miθra- "contract", etc.

Mutations at the mei-41, mus(1)101, mus(1)103, mus(2)205 and mus(3)310 loci of Drosophila exhibit differential UDS responses with different DNA-damaging agents

International Nuclear Information System (INIS)

Dusenbery, R.L.

1987-01-01

5 mutagen-sensitive mutants of Drosophila melanogaster, reported to perform normal or only slightly reduced excision repair of UV damage, were examined by an unscheduled DNA synthesis (UDS) assay. 2 mutants, classified as completely or partially proficient for both excision and postreplication repair of UV damage, mus(1)103 and mus(2)205, were found to give positive UDS responses only for UV damage. These mutants exhibit no measurable UDS activity following DNA damage by several different alkylating agents and X-rays. 3 mutants, classified as having no defect in excision repair, but measurable defects in postreplication repair of UV damage, exhibit 3 different response patterns. The mutant mei-41 exhibits a highly positive UDS response following damage by all agents, consistent with its prior classification as excision-repair-proficient, but postreplication-repair-deficient for UV damage. The mutant mus(1)101, however, exhibits a strong positive UDS response following only UV damage and appears to be blocked in the excision repair of damage produced by both alkylating agents and X-irradiation. Finally, mus(3)310 exhibits no UDS response to alkylation, X-ray or UV damage. This is not consistent with its previous classification. Results obtained w0272the qualitative in vitro UDS assay are entirely consistent with the results from two separate in vivo measures of excision repair deficiency followign DNA damage, larval hypersensitivity to killing and hypermutability in the sex-linked recessive lethal test. (Auth.)

Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors.

Science.gov (United States)

Dard, Amélie; Reboulet, Jonathan; Jia, Yunlong; Bleicher, Françoise; Duffraisse, Marilyne; Vanaker, Jean-Marc; Forcet, Christelle; Merabet, Samir

2018-03-13

HOX proteins achieve numerous functions by interacting with the TALE class PBX and MEIS cofactors. In contrast to this established partnership in development and disease, how HOX proteins could interact with PBX and MEIS remains unclear. Here, we present a systematic analysis of HOX/PBX/MEIS interaction properties, scanning all paralog groups with human and mouse HOX proteins in vitro and in live cells. We demonstrate that a previously characterized HOX protein motif known to be critical for HOX-PBX interactions becomes dispensable in the presence of MEIS in all except the two most anterior paralog groups. We further identify paralog-specific TALE-binding sites that are used in a highly context-dependent manner. One of these binding sites is involved in the proliferative activity of HOXA7 in breast cancer cells. Together these findings reveal an extraordinary level of interaction flexibility between HOX proteins and their major class of developmental cofactors. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Determination of 2-methylimidazole and 4-methylimidazole in caramel colors by capillary electrophoresis.

Science.gov (United States)

Petruci, João Flávio da Silveira; Pereira, Elisabete Alves; Cardoso, Arnaldo Alves

2013-03-06

The use of chemical preservative compounds is common in the food products industry. Caramel color is the most usual additive used in beverages, desserts, and breads worldwide. During its fabrication process, 2- and 4-methylimidazole (MeI), highly carcinogenic compounds, are generated. In these cases, the development of reliable analytical methods for the monitoring of undesirable compounds is necessary. The primary procedure for the analysis of 2- and 4-MeI is using LC- or GC-MS techniques. These procedures are time-consuming and require large amounts of organic solvents and several pretreatment steps. This prevents the routine use of this procedure. This paper describes a rapid, efficient, and simple method using capillary electrophoresis (CE) for the separation and determination of 2- and 4-MeI in caramel colors. The analyses were performed using a 75 μm i.d. uncoated fused-silica capillary with an effective length of 40 cm and a running electrolyte consisting of 160 mmol L(-1) phosphate plus 30% acetonitrile. The pH was adjusted to 2.5 with triethylamine. The analytes were separated within 6 min at a voltage of 20 kV. Method validation revealed good repeatability of both migration time (<0.8% RSD) and peak area (<2% RSD). Analytical curves for 2- and 4-MeI were linear in the 0.4-40 mg L(-1) concentration interval. Detection limits were 0.16 mg L(-1) for 4-MeI and 0.22 mg L(-1) for 2-MeI. The extraction recoveries were satisfactory. The developed method showed many advantages when compared to the previously used method.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Mei Luo. Articles written in Journal of Chemical Sciences. Volume 127 Issue 1 January 2015 pp 163-166 Regular Articles. Efficient one-pot synthesis of 2-oxazolines from benzoylacetonitrile and -aminoalcohols mediated by ZnCl2 · Mei Luo Jing Cheng Zhang Hao Yin.

World's finest tech sites immortalised

CERN Multimedia

2008-01-01

They may have transformed man's understanding of the universe but the monumental impact of the world's first large radio telescope and the planet's largest particle physics lab has never been fully recognised. Now both Jodrell Bank and CERN are among the technological landmarks that could be immortalised alongside the pyramids of Egypt and Taj Mahal on UNESCO's World Heritage Site (WHS) list.

Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MS/MS

Directory of Open Access Journals (Sweden)

Martyna N. Wieczorek

2018-01-01

Full Text Available One of Maillard reaction products formed in the production of ammonia caramel is 4(5-methylimidazole (4-MeI classified as carcinogen. A method of 4-MeI determination based on ion-pair extraction and derivatisation with isobutyl chloroformate with subsequent gas chromatography-tandem mass spectrometry analysis was proposed. Tandem mass spectrometry was applied to reduce the influence of matrix and increase the selectivity and sensitivity of the method. Triple quadrupole GC-MS system was used for this study. The collision energies were optimized for MRM mode. The detection (LOD and quantification limits (LOQ of the elaborated method were 17 and 37.8 μg kg−1, respectively, repeatability was <15% RSD for analyzed caramel samples, and the recovery for 4-MeI was 101%. Comparison of MS/MS with SIM detection on the same instrument proved almost 30 times lower LODs achieved by tandem mass spectrometry compared to SIM. Described method can be routinely used for monitoring 4-MeI as a quality and safety marker in the production of ammonia caramel.

Vijftig jaar Israël. Water struikelblok voor vrede

NARCIS (Netherlands)

Donkers, H.W.H.A.

1998-01-01

Op 15 mei van dit jaar was het vijftig jaar geleden dat David Ben-Goerion de staat Israel uitriep. Een van de rode draden in de geschiedenis van de joodse staat is de toegang tot water. Water is schaars in het Midden-Oosten. Na 15 mei 1948 ontstond er al snel een strijd om water met de andere

[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, February 1, 1993 - November 1, 1994

International Nuclear Information System (INIS)

Hawley, R.S.

1998-01-01

This research focuses on two repair deficient mutations in Drosophila melanogaster, namely mei-9, mei-41. In addition, the authors propose to extend this study to include the mus-312 mutation. They expect these studies to provide substantial insights into both the molecular mechanisms of DNA repair in Drosophila and the role these genes play in normal biological processes

A Method for Absolute Determination of the Surface Areal Density of Functional Groups in Organic Thin Films

Energy Technology Data Exchange (ETDEWEB)

Min, Hyegeun; Son, Jin Gyeong; Kim, Jeong Won; Yu, Hyunung; Lee, Tae Geol; Moon, Dae Won [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

2014-03-15

To develop a methodology for absolute determination of the surface areal density of functional groups on organic and bio thin films, medium energy ion scattering (MEIS) spectroscopy was utilized to provide references for calibration of X-ray photoelectron spectroscopy (XPS) or Fourier transformation-infrared (FT-IR) intensities. By using the MEIS, XPS, and FT-IR techniques, we were able to analyze the organic thin film of a Ru dye compound (C{sub 58}H{sub 86}O{sub 8}N{sub 8}S{sub 2}Ru), which consists of one Ru atom and various stoichiometric functional groups. From the MEIS analysis, the absolute surface areal density of Ru atoms (or Ru dye molecules) was determined. The surface areal densities of stoichiometric functional groups in the Ru dye compound were used as references for the calibration of XPS and FT-IR intensities for each functional group. The complementary use of MEIS, XPS, and FT-IR to determine the absolute surface areal density of functional groups on organic and bio thin films will be useful for more reliable development of applications based on organic thin films in areas such as flexible displays, solar cells, organic sensors, biomaterials, and biochips.

Management of remanent lifetime. Short-term benefits of the maintenance evaluation and improvement programme

International Nuclear Information System (INIS)

Sainero Garcia, J.

1993-01-01

Remanent Lifetime Management, which is scientifically based on knowing the degradatory phenomena associated with aging, today allows us to optimize plant life through a long-term maintenance strategy combining preventive maintenance and condition monitoring programmes. Within a project for Remanent Lifetime Management (RLM), the determination of methods of control and mitigation of degradations due to aging depends on the programme of Maintenance Evaluation and Improvement (MEI). This programme, underpinned by the analysis of degradatory phenomena to which plant components are subjected, evaluates current maintenance practices and defines the complementary actions which would facilitate establishment of a long-term strategy to control aging. Together with this main objective of the RLM project, the MEI programme achieves short-term benefits since, right from the beginning, it offers solutions to mitigate and guard against degradations in crucial plant components, and generally sets out a programme to control aging. The MEI programme further serves as a tool to reach the final objectives of the new 10CFR50.65 rule, 'Requirements for Maintenance Programs for NPPs'. The MEI always offers the option should the Utility Owner decide to extend plant life. (author)

Management of remanent lifetime. Short-term benefits of the maintenance evaluation and improvement programme; Gestion de la vida remanente de instalaciones industriales. Extension de vida

Energy Technology Data Exchange (ETDEWEB)

Sainero Garcia, J [Empresarios Agrupados, Madrid (Spain)

1993-12-15

Remanent Lifetime Management, which is scientifically based on knowing the degradatory phenomena associated with aging, today allows us to optimize plant life through a long-term maintenance strategy combining preventive maintenance and condition monitoring programmes. Within a project for Remanent Lifetime Management (RLM), the determination of methods of control and mitigation of degradations due to aging depends on the programme of Maintenance Evaluation and Improvement (MEI). This programme, underpinned by the analysis of degradatory phenomena to which plant components are subjected, evaluates current maintenance practices and defines the complementary actions which would facilitate establishment of a long-term strategy to control aging. Together with this main objective of the RLM project, the MEI programme achieves short-term benefits since, right from the beginning, it offers solutions to mitigate and guard against degradations in crucial plant components, and generally sets out a programme to control aging. The MEI programme further serves as a tool to reach the final objectives of the new 10CFR50.65 rule, 'Requirements for Maintenance Programs for NPPs'. The MEI always offers the option should the Utility Owner decide to extend plant life. (author)

An Internal Dose Assessment Associated with Personal Food Intake

Energy Technology Data Exchange (ETDEWEB)

Lee, Joeun; Jae, Moosung [Hanyang University, Seoul (Korea, Republic of); Hwang, Wontae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

ICRP (International Commission on Radiological Protection), Therefore, had recommended the concept of 'Critical Group'. Recently the ICRP has recommended the use of 'Representative Person' on the new basic recommendation 103. On the other hand the U.S. NRC (Nuclear Regulatory Commission) has adopted more conservative concept, 'Maximum Exposed Individuals (MEI)' of critical Group. The dose assessment in Korea is based on MEI. Although dose assessment based on MEI is easy to receive the permission of the regulatory authority, it is not efficient. Meanwhile, the internal dose by food consumption takes an important part. Therefore, in this study, the internal dose assessment was performed in accordance with ICRP's new recommendations. The internal dose assessment was performed in accordance with ICRP's new recommendations. It showed 13.2% decreased of the annual internal dose due to gaseous effluents by replacing MEI to the concept of representative person. Also, this calculation based on new ICRP's recommendation has to be extended to all areas of individual dose assessment. Then, more accurate and efficient values might be obtained for dose assessment.

Karakteristik Penderita Penyakit Jantung Bawaan pada Anak di RSUP Dr. M. Djamil Padang Periode Januari 2010 – Mei 2012

Directory of Open Access Journals (Sweden)

Nur Ain

2015-09-01

Full Text Available Abstrak Penyakit jantung bawaan (PJB merupakan defek lahir yang sering ditemukan dan merupakan penyebab kematian terbanyak dari semua jenis kelainan bawaan. Banyak penelitian yang menunjukkan bahwa adanya variasi secara geografik yang penting pada insiden PJB. Tujuan penelitian ini adalah untuk mengetahui variasi karakteristik dari penderita PJB anak di RSUP Dr. M. Djamil Padang. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan melihat karakteristik penderita anak dengan PJB pada data rekam medik. Sampel penelitian ini adalah 55pasien anak yang menderita penyakit jantung bawaan di RSUP Dr. M. Djamil Padang dari Januari 2010 sampai Mei 2012. Mayoritas penderita adalah perempuan (61,8%, dan mayoritas umur sampel terdapat pada kelompok umur kurang dari 1 tahun (56.4%. Jenis PJB terbanyak adalah TF (21,8% dan gejala yang paling sering dijumpai adalah sesak nafas (50,9%. Sebanyak (34,5% penderita memiliki penyakit kongenital lain, dengan penyakit nonsindroma terbanyak adalah atresia ani dan omfalokel dengan masing-masing (22,2% dan penyakit sindroma terbanyak adalahsindroma Down (40%. Gagal tumbuh terdapat pada (49,1% penderita. Nilai Hb PJB sianotik lebih tinggi berbanding asianotik. Tingkat tindakan operatif kasus PJB anak di RSUP Dr. M. Djamil Padang adalah 1,8%. Terdapat variasi karakteristik dari penderita PJB yang ada di RSUP Dr. M. Djamil Padang.Kata kunci: penyakit jantung bawaan, anak, variasi karakteristik Abstract Congenital heart disease (CHD is a common birth defect, and a leading cause of deaths linked to birth defects. Many studies show that the presence of significant geographic variation in the incidence of CHD. The objective of this study was to determine the variation of the characteristics of patients with CHD in Dr. M. Djamil Hospital Padang. This research is a descriptive research by observing at the characteristics of children with CHD using the medical record data. The total sample of this study was 55

MEIS homeobox genes in neuroblastoma

NARCIS (Netherlands)

Geerts, Dirk; Revet, Ingrid; Jorritsma, Gerda; Schilderink, Nathalie; Versteeg, Rogier

2005-01-01

The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of

Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens

International Nuclear Information System (INIS)

Boyd, J.B.; Golino, M.D.; Nguyen, T.D.; Green, M.M.

1976-01-01

Thirteen X-linked mutants have been isolated in Drosophila melanogaster which render male and homozygous female larvae sensitive to the mutagen methyl methanesulfonate. Their characterization and preliminary assignment to functional groups is described. Four of these mutants are alleles of mei-41. Like previously isolated alleles of this locus, these mutants reduce fertility and increase loss and nondisjunction of the X-chromosome in homozygous females. The remaining mutants have been tentatively assigned to six functional groups (two mutants to the mus(1)101 locus, two to mus(1)102, two to mus(1)103, and one each to mus(1)104, mus(1)105, and mus(1)106. Several of the complementation groups can be distinguished on the basis of nondisjunction and cross sensitivity to mutagens. Females homozygous for the mei-41, mus(1)101 and mus(1)102 mutants exhibit elevated levels of nondisjunction. Mutants belonging to complementation groups mei-41, mus(1)101, and mus(1)104 are sensitive to nitrogen mustard (HN2) in addition to their MMS sensitivity. Among these mutants there is currently a direct correlation between sensitivity to HN2, sensitivity to 2-acetylaminofluorene and a deficiency in post-replication repair. Only the mei-41 mutants are hypersensitive to uv radiation, although several of the mutants exhibit sensitivity to γ-rays. Semidominance is observed in female larvae of the mei-41, mus(1)104, and mus(1)103 mutants after exposure to high concentrations of MMS. The properties of the mutants generally conform to a pattern which has been established for related mutants in yeast

Impact of a highly detailed emission inventory on modeling accuracy

Science.gov (United States)

Taghavi, M.; Cautenet, S.; Arteta, J.

2005-03-01

During Expérience sur Site pour COntraindre les Modèles de Pollution atmosphérique et de Transport d'Emissions (ESCOMPTE) campaign (June 10 to July 14, 2001), two pollution events observed during an intensive measurement period (IOP2a and IOP2b) have been simulated. The comprehensive Regional Atmospheric Modeling Systems (RAMS) model, version 4.3, coupled online with a chemical module including 29 species is used to follow the chemistry of a polluted zone over Southern France. This online method takes advantage of a parallel code and use of the powerful computer SGI 3800. Runs are performed with two emission inventories: the Emission Pre Inventory (EPI) and the Main Emission Inventory (MEI). The latter is more recent and has a high resolution. The redistribution of simulated chemical species (ozone and nitrogen oxides) is compared with aircraft and surface station measurements for both runs at regional scale. We show that the MEI inventory is more efficient than the EPI in retrieving the redistribution of chemical species in space (three-dimensional) and time. In surface stations, MEI is superior especially for primary species, like nitrogen oxides. The ozone pollution peaks obtained from an inventory, such as EPI, have a large uncertainty. To understand the realistic geographical distribution of pollutants and to obtain a good order of magnitude in ozone concentration (in space and time), a high-resolution inventory like MEI is necessary. Coupling RAMS-Chemistry with MEI provides a very efficient tool able to simulate pollution plumes even in a region with complex circulations, such as the ESCOMPTE zone.

Genetic background in partitioning of metabolizable energy efficiency in dairy cows.

Science.gov (United States)

Mehtiö, T; Negussie, E; Mäntysaari, P; Mäntysaari, E A; Lidauer, M H

2018-05-01

The main objective of this study was to assess the genetic differences in metabolizable energy efficiency and efficiency in partitioning metabolizable energy in different pathways: maintenance, milk production, and growth in primiparous dairy cows. Repeatability models for residual energy intake (REI) and metabolizable energy intake (MEI) were compared and the genetic and permanent environmental variations in MEI were partitioned into its energy sinks using random regression models. We proposed 2 new feed efficiency traits: metabolizable energy efficiency (MEE), which is formed by modeling MEI fitting regressions on energy sinks [metabolic body weight (BW 0.75 ), energy-corrected milk, body weight gain, and body weight loss] directly; and partial MEE (pMEE), where the model for MEE is extended with regressions on energy sinks nested within additive genetic and permanent environmental effects. The data used were collected from Luke's experimental farms Rehtijärvi and Minkiö between 1998 and 2014. There were altogether 12,350 weekly MEI records on 495 primiparous Nordic Red dairy cows from wk 2 to 40 of lactation. Heritability estimates for REI and MEE were moderate, 0.33 and 0.26, respectively. The estimate of the residual variance was smaller for MEE than for REI, indicating that analyzing weekly MEI observations simultaneously with energy sinks is preferable. Model validation based on Akaike's information criterion showed that pMEE models fitted the data even better and also resulted in smaller residual variance estimates. However, models that included random regression on BW 0.75 converged slowly. The resulting genetic standard deviation estimate from the pMEE coefficient for milk production was 0.75 MJ of MEI/kg of energy-corrected milk. The derived partial heritabilities for energy efficiency in maintenance, milk production, and growth were 0.02, 0.06, and 0.04, respectively, indicating that some genetic variation may exist in the efficiency of using

Oblici tradicijske arhitekture i kulture stanovanja u Baranji

OpenAIRE

Puntarović-Vlahinić, Jadranka

1993-01-01

Obrađeni su i prikazani podaci prikupljeni za Etnološki atlas koji se odnose na tipove naselja, osnovne značajke kućišta, te na oblike stambenih zgrada u Baranji. Tome su dodani zabilježeni podaci o rasporedu prostorija, njihovoj funkciji, te o njihovu unutarnjem uređenju i opremi (namještaj, oprema kuhinje, pravljenje ognja, peći i grijanje, rasvjeta).

HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.

Science.gov (United States)

De Kumar, Bony; Parker, Hugo J; Paulson, Ariel; Parrish, Mark E; Pushel, Irina; Singh, Narendra Pratap; Zhang, Ying; Slaughter, Brian D; Unruh, Jay R; Florens, Laurence; Zeitlinger, Julia; Krumlauf, Robb

2017-09-01

Hoxa1 has diverse functional roles in differentiation and development. We identify and characterize properties of regions bound by HOXA1 on a genome-wide basis in differentiating mouse ES cells. HOXA1-bound regions are enriched for clusters of consensus binding motifs for HOX, PBX, and MEIS, and many display co-occupancy of PBX and MEIS. PBX and MEIS are members of the TALE family and genome-wide analysis of multiple TALE members (PBX, MEIS, TGIF, PREP1, and PREP2) shows that nearly all HOXA1 targets display occupancy of one or more TALE members. The combinatorial binding patterns of TALE proteins define distinct classes of HOXA1 targets, which may create functional diversity. Transgenic reporter assays in zebrafish confirm enhancer activities for many HOXA1-bound regions and the importance of HOX-PBX and TGIF motifs for their regulation. Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions. Therefore, TALE proteins appear to represent a wide repertoire of HOX cofactors, which may coregulate enhancers through distinct mechanisms. We also discover extensive auto- and cross-regulatory interactions among the Hoxa1 and TALE genes, indicating that the specificity of HOXA1 during development may be regulated though a complex cross-regulatory network of HOXA1 and TALE proteins. This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins. © 2017 De Kumar et al.; Published by Cold Spring Harbor Laboratory Press.

The Effect of ENSO on Phytoplankton Composition in the Pacific Ocean

Science.gov (United States)

Rousseaux, Cecile

2012-01-01

The effect of climate variability on phytoplankton communities was assessed for the tropical and sub-tropical Pacific Ocean between 1998 and 2005 using an established biogeochemical assimilation model. The phytoplankton communities exhibited wide range of responses to climate variability, from radical shifts in the Equatorial Pacific, to changes of only a couple of phytoplankton groups in the North Central Pacific, to no significant changes in the South Pacific. In the Equatorial Pacific, climate variability dominated the variability of phytoplankton. Here, nitrate, chlorophyll and all but one of the 4 phytoplankton types (diatoms, cyanobacteria and coccolithophores) were strongly correlated (p less than 0.01) with the Multivariate El Nino Southern Oscillation Index (MEI). In the North Central Pacific, MEI and chlorophyll were significantly (pphytoplankton groups (chlorophytes and coccolithophores). Ocean biology in the South Pacific was not significantly correlated with MEI. During La Ni a events, diatoms increased and expanded westward along the cold tongue (correlation with MEI, r=-0.81), while cyanobacteria concentrations decreased significantly (r=0.78). El Nino produced the reverse pattern, with cyanobacteria populations increasing while diatoms plummeted. The diverse response of phytoplankton in the different major basins of the Pacific suggests the different roles climate variability can play in ocean biology.

Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route

Directory of Open Access Journals (Sweden)

Surjyanarayan Mandal

2015-09-01

Full Text Available This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (MEI and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain uptake of ibuprofen via nasal route was studied by performing biodistribution study in Swiss albino rats. MEI was found to be transparent, stable and non ciliotoxic with 66.29 ± 4.15 nm, -20.9 ± 3.98 mV and 98.66 ± 1.01% as average globule size, zeta potential and drug content respectively. Transmission Electron Microscopy (TEM study revealed the narrow globule size distribution of MEI. Following single intranasal administration of MMEI and MEI at a dose of 2.86 mg/kg, uptake of ibuprofen in the olfactory bulb was around 3.0 and 1.7 folds compared with intravenous injection of ibuprofen solution (IDS. The ratios of AUC in brain tissues to that in plasma obtained after nasal administration of MMEI were significantly higher than those after intravenous administration of IDS. Findings of the present investigation revealed that the developed mucoadhesive microemulsion gel could be a promising approach for brain targeting of ibuprofen through intranasal route.

US Department of Energy report 1996 LANL radionuclide air emissions

Energy Technology Data Exchange (ETDEWEB)

Jacobson, K.W.

1997-08-01

Presented is the Laboratory-wide certified report regarding radioactive effluents released into the air by the Los Alamos National Laboratory (LANL) in 1996. This information is required under the Clean Air Act and is being reported to the U.S. Environmental Protection Agency (EPA). The effective dose equivalent (EDE) to a hypothetical maximum exposed individual (MEI) of the public was calculated, using procedures specified by the EPA and described in this report. That dose was 1.93 mrem for 1996. Emissions of {sup 11}C, {sup 13}N, and {sup 15}O from a 1-mA, 800 MeV proton accelerator contributed over 92% of the EDE to LANL`s MEI. Using CAP88, the EPA`s dose assessment model, more than 86% of the total dose received by the MEI was via the air immersion pathway.

Chromosome stickiness during meiotic behavior analysis of Passiflora serrato-digitata L. (PassifloraCEAE Aderência cromossômica durante a análise do comportamento meiótico de Passiflora serrato-digitata L (PassifloraCEAE

Directory of Open Access Journals (Sweden)

Paulo Roberto Peres Kiihl

2011-06-01

refrigeração. As lâminas foram preparadas pela técnica de esmagamento e coradas com carmim propiônico a 1,0% e observadas ao microscópio óptico. Por meio da análise do comportamento meiótico, foram verificadas irregularidades no processo de segregação dos cromossomos de P. serrato-digitata, tais como migração precoce para os pólos em metáfase I e II, cromossomos não orientados na placa equatorial em metáfase I e II, cromossomos retardatários em anáfase I e II, levando a formação de micronúcleo em telófases I e II e micrósporos em tétrades. Outra irregularidade observada foi aderência cromossômica, relatada pela primeira vez no gênero Passiflora, que também pode ter contribuído para a formação de mônades, díades, tríades, as quais foram observadas, resultando em micrósporos normais, desbalanceados, 2n e 4n. De acordo com o Índice Meiótico de 71,83% observado, essa espécie pode ser classificada como não estável meioticamente.

Utjecaj migracija na objektivne uvjete života obitelji maloljetnih delinkvenata

OpenAIRE

Vujović, Tatjana

2015-01-01

Intenzivno doseljavanje seoskog stanovništva u gradovima Crne Gore tokom druge polovine 20. vijeka, neravnomjeran razmještaj, problemi u adaptaciji, loši stambeni uvjeti, nezaposlenost kao i evidentna ispoljavanja ekonomske, socijalne i moralne krize imali su za posljedicu pojavu brojnih socio-patoloških pojava kao što su: kriminalitet, zlouporaba psihoaktivnih supstanci, suicid, prosjačenje, dezintegracija obitelji. Cilj ovog znanstvenog rada bio je sagledati da li postoji sta...

CSI cardiac prevent 2015

OpenAIRE

S Ramakrishnan; Manisha Kaushik

2015-01-01

The CSI Cardiac Prevent 2015 was held at Hotel Taj Palace, New Delhi, on September 25-27, 2015. The major challenge was to create interest among cardiologists and physicians on preventive cardiology, a neglected area. The theme of the conference was "Innovations in Heart Disease Prevention.′′ This conference included "CSI at WHF Roadmap Workshop, Inauguration Ceremony, scientific program, plenary sessions, Nursing/Dietician track, Industry Exhibition, Social Events," Great India blood pressur...

Treatment of personal status in jurisdictions of selected Arab states

OpenAIRE

Kopecký, Robert

2006-01-01

In my dissertation thesis I tried to explicate the fundamental institutes of Islamic family law, according to modern and contemporary legislation in a number of Arab states. The family law is fairly exhaustively treated in the sacred book of Muslims, in Koran, albeit in a number of scattered passages, mostly in suras from Medinese period. These passages are defined with more precision by the prestigeous method of the interpretation of Koran, with so called taj

Fuels derived from starch digestion have different effects on energy intake and metabolic responses of cows in the postpartum period.

Science.gov (United States)

Gualdrón-Duarte, Laura B; Allen, Michael S

2018-03-07

Absorbed fuels from the digestion of starch include propionic acid (PA) produced by ruminal fermentation and glucose (GLU) from intestinal digestion, which may be partially metabolized to lactic acid (LA) by intestinal tissues. Our objective was to evaluate the effects of these fuels on dry matter intake (DMI) and feeding behavior of cows in the postpartum period. We hypothesized that these fuels affect feed intake differently and that their effects are related to differences in their hepatic metabolism. Glucose was expected to have little effect on feed intake because little or no GLU is extracted from the blood by the liver. Whereas both LA and PA are anaplerotic and can stimulate oxidation of acetyl CoA in hepatocytes, hepatic extraction of PA is greater than LA, which depends on cytosolic redox state. Continuous isoenergetic infusions (150 kcal of ME/h) of PA, LA, or GLU or no infusion were administered abomasally to 8 ruminally cannulated multiparous Holstein cows (12.4 ± 6.2 d postpartum) in a duplicate 4 × 4 Latin square design experiment, with four 1-d infusion periods, balanced for carry-over effects. Treatment sequences were assigned to cows randomly, and treatments included control (CON, no infusion), PA (0.41 mol/h), LA (0.46 mol/h), and GLU (0.22 mol/h). Solutions containing treatments were infused at 500 mL/h for 22 h/d and provided ~3.3 Mcal/d. Feeding behavior was recorded by a computerized data acquisition system. Gross energy digestibility of the diet was determined for each cow and used to calculate metabolizable energy intake (MEI) from the diet. Total MEI was calculated as the sum of MEI from the diet plus energy from infusions. Data were analyzed statistically with a mixed model including the fixed effect of treatment and random effects of block and cow within block. Each treatment was compared with CON by contrasts. Compared with CON, PA decreased DMI by 24% (14.3 vs. 18.9 kg/d) and total MEI by 13% (34.8 vs. 40.2 Mcal/d) with a tendency to

Unified Symmetry and Conserved Quantities of Mechanical System in Phase Space

International Nuclear Information System (INIS)

Fang Jianhui; Ding Ning; Wang Peng

2006-01-01

In this paper, a new symmetry and its conserved quantities of a mechanical system in phase space are studied. The definition of this new symmetry, i.e., a unified one is presented, and the criterion of this symmetry is also given. The Noether, the generalized Hojman and the Mei conserved quantities of the unified symmetry of the system are obtained. The unified symmetry contains the Noether, the Lie and the Mei symmetries, and has more generalized significance.

NESHAP Area-Specific Dose-Release Factors for Potential Onsite Member-of-the-Public Locations at SRS using CAP88-PC Version 4.0

Energy Technology Data Exchange (ETDEWEB)

Trimor, P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2017-08-09

The Environmental Protection Agency (EPA) requires the use of the computer model CAP88-PC to estimate the total effective doses (TED) for demonstrating compliance with 40 CFR 61, Subpart H (EPA 2006), the National Emission Standards for Hazardous Air Pollutants (NESHAP) regulations. As such, CAP88 Version 4.0 was used to calculate the receptor dose due to routine atmospheric releases at the Savannah River Site (SRS). For estimation, NESHAP dose-release factors (DRFs) have been supplied to Environmental Compliance and Area Closure Projects (EC&ACP) for many years. DRFs represent the dose to a maximum receptor exposed to 1 Ci of a specified radionuclide being released into the atmosphere. They are periodically updated to include changes in the CAP88 version, input parameter values, site meteorology, and location of the maximally exposed individual (MEI). In this report, the DRFs were calculated for potential radionuclide atmospheric releases from 13 SRS release points. The three potential onsite MEI locations to be evaluated are B-Area, Three Rivers Landfill (TRL), and Savannah River Ecology Lab Conference Center (SRELCC) with TRL’s onsite workers considered as members-of-the-public, and the potential future constructions of dormitories at SRELCC and Barracks at B-Area. Each MEI location was evaluated at a specified compass sector with different area to receptor distances and was conducted for both ground-level and elevated release points. The analysis makes use of area-specific meteorological data (Viner 2014). The resulting DRFs are compared to the 2014 NESHAP offsite MEI DRFs for three operational areas; A-Area, H-Area, and COS for a release rate of 1 Ci of tritium oxide at 0 ft. elevation. CAP88 was executed again using the 2016 NESHAP MEI release rates for 0 and 61 m stack heights to determine the radionuclide dose at TRL from the center-of-site (COS).

Structure and magnetic exchange coupling of iron based trilayers

International Nuclear Information System (INIS)

Mendus, T.

1998-12-01

A study of the structural and magnetic properties of Fe based magnetic trilayers is presented. Sample preparation conditions were altered to achieve the best growth conditions and their effect on the magnetic properties determined. Structural information was obtained from RHEED, AES, STM and MEIS; this is believed to be the first time that MEIS has been used to look at this sort of sample. Magnetic characterisation was determined by MOKE with particular interest paid to the biquadratic coupling. The determination of magnetic coupling as a function of sample morphology was studied oil a series of Fe/Cr/Fe samples. Fe/Au/Fe samples oil MgO substrates were also prepared to facilitate MEIS studies. Results indicate that tile fluctuation model best describes tile observed biquadratic coupling in Fe/Cr/Fe trilayers and that the presence of clean, sharp interfaces is required. Annealing and growth at elevated temperature cause interdiffusion at the interfaces, weakening the biquadratic coupling. MEIS structural data from MgO/Fe/Au/Fe samples shows that tile layer structure is dependent oil thickness. There is an apparent reorganisation of tile Au interlayer between a 'bcc'-Iike phase towards tile bulk fcc phase as the layer thickness increases. MEIS is shown to be a very sensitive probe of the crystalline quality and is a powerful probe for the determination of postdeposition sample morphology. Results from an EC collaboration investigating Co/Cr/Co trilayers are also presented. They showed that interlayer coupling and anisotropy of the samples were very sensitive to the preparation conditions. A decrease in the coupling strength is found for sample growth under non-ideal conditions (growth in an applied field, growth at an angle and delays between layer growth). (author)

Role of UDP-Glucuronosyltransferase (UGT) 2B2 in Metabolism of Triiodothyronine: Effect of Microsomal Enzyme Inducers in Sprague Dawley and UGT2B2-Deficient Fischer 344 Rats

Science.gov (United States)

Richardson, Terrilyn A.; Klaassen, Curtis D.

2010-01-01

Microsomal enzyme inducers (MEI) that increase UDP-glucuronosyltransferases (UGTs) can impact thyroid hormone homeostasis in rodents. Increased glucuronidation can result in reduction of serum thyroid hormone and a concomitant increase in thyroid-stimulating hormone (TSH). UGT2B2 is thought to glucuronidate triiodothyronine (T3). The purposes of this study were to determine the role of UGT2B2 in T3 glucuronidation and whether increased T3 glucuronidation mediates the increased TSH observed after MEI treatment. Sprague Dawley (SD) and UGT2B2-deficient Fischer 344 (F344) rats were fed a control diet or diet containing pregnenolone-16α-carbonitrile (PCN; 800 ppm), 3-methylcholanthrene (3-MC; 200 ppm), or Aroclor 1254 (PCB; 100 ppm) for 7 days. Serum thyroxine (T4), T3, and TSH concentrations, hepatic androsterone/T4/T3 glucuronidation, and thyroid follicular cell proliferation were determined. In both SD and F344 rats, MEI treatments decreased serum T4, whereas serum T3 was maintained (except with PCB treatment). Hepatic T4 glucuronidation increased significantly after MEI in both rat strains. Compared with the other MEI, only PCN treatment significantly increased T3 glucuronidation (281 and 497%) in both SD and UGT2B2-deficient F344 rats, respectively, and increased both serum TSH and thyroid follicular cell proliferation. These data demonstrate an association among increases in T3 glucuronidation, TSH, and follicular cell proliferation after PCN treatment, suggesting that T3 is glucuronidated by other PCN-inducible UGTs in addition to UGT2B2. These data also suggest that PCN (rather than 3-MC or PCB) promotes thyroid tumors through excessive TSH stimulation of the thyroid gland. PMID:20421340

Pacific Northwest National Laboratory Site Radionuclide Air Emissions Report for Calendar Year 2011

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F.; Barnett, J. Matthew; Bisping, Lynn E.

2012-06-12

This report documents radionuclide air emissions that result in the highest effective dose equivalent (EDE) to a member of the public, referred to as the maximally exposed individual (MEI). The report has been prepared in compliance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (NESHAP), Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities and Washington Administrative Code (WAC) Chapter 246-247, Radiation ProtectionAir Emissions. The EDE to the PNNL Site MEI due to routine emissions in 2011 from PNNL Site sources was 1.7E 05 mrem (1.7E-7 mSv) EDE. No nonroutine emissions occurred in 2011. The total radiological dose for 2011 to the MEI from all PNNL Site radionuclide emissions was more than 10,000 times smaller than the federal and state standard of 10 mrem/yr, to which the PNNL Site is in compliance.

3rd International Symposium Mathematical Progress in Expressive Image Synthesis

CERN Document Server

Ochiai, Hiroyuki

2016-01-01

“Progress in Expressive Image Synthesis” (MEIS2015), was held in Fukuoka, Japan, September 25–27, 2015. The aim of the symposium was to provide a unique venue where various issues in computer graphics (CG) application fields could be discussed by mathematicians, CG researchers, and practitioners. Through the previous symposiums MEIS2013 and MEIS2014, mathematicians as well as CG researchers have recognized that CG is a specific and practical activity derived from mathematical theories. Issues found in CG broaden the field of mathematics and vice versa, and CG visualizes mathematical theories in an aesthetic manner. In this volume, the editors aim to provoke interdisciplinary research projects through the peer-reviewed papers and poster presentations at the this year’s symposium. This book captures interactions among mathematicians, CG researchers, and practitioners sharing important, state-of-the-art issues in graphics and visual perception. The book is suitable for all CG researchers seeking open pro...

Novel Application of a Multiscale Entropy Index as a Sensitive Tool for Detecting Subtle Vascular Abnormalities in the Aged and Diabetic

Directory of Open Access Journals (Sweden)

Hsien-Tsai Wu

2013-01-01

Full Text Available Although previous studies have shown the successful use of pressure-induced reactive hyperemia as a tool for the assessment of endothelial function, its sensitivity remains questionable. This study aims to investigate the feasibility and sensitivity of a novel multiscale entropy index (MEI in detecting subtle vascular abnormalities in healthy and diabetic subjects. Basic anthropometric and hemodynamic parameters, serum lipid profiles, and glycosylated hemoglobin levels were recorded. Arterial pulse wave signals were acquired from the wrist with an air pressure sensing system (APSS, followed by MEI and dilatation index (DI analyses. MEI succeeded in detecting significant differences among the four groups of subjects: healthy young individuals, healthy middle-aged or elderly individuals, well-controlled diabetic individuals, and poorly controlled diabetic individuals. A reduction in multiscale entropy reflected age- and diabetes-related vascular changes and may serve as a more sensitive indicator of subtle vascular abnormalities compared with DI in the setting of diabetes.

Daily Feed Intake, Energy Intake, Growth Rate and Measures of Dietary Energy Efficiency of Pigs from Four Sire Lines Fed Diets with High or Low Metabolizable and Net Energy Concentrations

Directory of Open Access Journals (Sweden)

A. P. Schinckel

2012-03-01

Full Text Available A trial was conducted to: i evaluate the BW growth, energy intakes and energetic efficiency of pigs fed high and low density diets from 27 to 141 kg BW, ii evaluate sire line and sex differences when fed both diets, and iii to compare ME to NE as predictor of pig performance. The experiment had a replicated factorial arrangement of treatments including four sire lines, two sexes (2,192 barrows and 2,280 gilts, two dietary energy densities and a light or heavy target BW, 118 and 131.5 kg in replicates 1 to 6 and 127 and 140.6 kg in replicates 7 to 10. Pigs were allocated to a series of low energy (LE, 3.27 Mcal ME/kg corn-soybean meal based diets with 16% wheat midds or high energy diets (HE, 3.53 to 3.55 Mcal ME/kg with 4.5 to 4.95% choice white grease. All diets contained 6% DDGS. The HE and LE diets of each of the four phases were formulated to have equal lysine:Mcal ME ratios. Pigs were weighed and pen feed intake (11 or 12 pigs/pen recorded at 28-d intervals. The barrow and gilt daily feed (DFI, ME (MEI and NE (NEI intake data were fitted to a Bridges function of BW. The BW data of each sex were fitted to a generalized Michaelis-Menten function of days of age. ME and NE required for maintenance (Mcal/d were predicted using functions of BW (0.255 and 0.179 BW^0.60 respectively. Pigs fed LE diets had decreased ADG (915 vs. 945 g/d, p<0.001 than pigs fed HE diets. Overall, DFI was greater (p<0.001 for pigs fed the LE diets (2.62 vs. 2.45 kg/d. However, no diet differences were observed for MEI (8.76 vs. 8.78 Mcal/d, p = 0.49 or NEI (6.39 vs. 6.44 Mcal/d, p = 0.13, thereby indicating that the pigs compensated for the decreased energy content of the diet. Overall ADG:DFI (0.362 vs. 0.377 and ADG:Mcal MEI (0.109 vs. 0.113 was less (p<0.001 for pigs fed LE compared to HE diets. Pigs fed HE diets had 3.6% greater ADG:Mcal MEI above maintenance and only 1.3% greater ADG:Mcal NEI (0.152 versus 0.150, therefore NEI is a more accurate predictor of

Ohutsoonid on meis endis / Kalle Laanet

Index Scriptorium Estoniae

Laanet, Kalle, 1965-

2006-01-01

Ilmunud ka: Meie Maa 21. okt. lk. 2, Järva Teataja, Vooremaa, Koit 24. okt. lk. 2,2,6, Molodjozh Estonii 25. okt. lk. 5, Postimees : na russkom jazõke 26. okt. lk. 7, Pjarnuskii Ekspress 27. okt. lk. 7, Pärnu Postimees, Vesti Nedeli Den za Dnjom 3. nov. lk. 21,14, Sillamjaeskii Vestnik 18. nov. lk. 3. Siseminister Kalle Laanet kirjutab ohutsoonist pronkssõduri ümber, sisejulgeolekust, liikluskultuurist, teistega arvestamisest ühiskonnas, infohäiretest põhjustatud konfliktidest

Radioactive Air Emissions Notice of Construction (NOC) for the Fuel Removal Project

International Nuclear Information System (INIS)

JOHNSON, R.E.

2000-01-01

This NOC describes the activities to remove all spent nuclear fuel (SNF) assemblies from the spent fuel pool in the T Plant Complex 221-T canyon for interim storage in the Canister Storage Building (CSB). The unabated total effective dose equivalent (TEDE) estimated for the public hypothetical maximally exposed individual (MEI) is 5.7 E-6 millirem (mrem) per year for this fuel removal NOC. The abated TEDE conservatively is estimated to account for 2.9 E-9 mrem per year to the MEI

Radioactive Air Emissions Notice of Construction (NOC) for the Solid Waste Treatment Facility (T Plant) Fuel Removal Project

Energy Technology Data Exchange (ETDEWEB)

JOHNSON, R.E.

2000-11-16

This NOC describes the activities to remove all spent nuclear fuel (SNF) assemblies from the spent fuel pool in the T Plant Complex 221-T canyon for interim storage in the Canister Storage Building (CSB). The unabated total effective dose equivalent (TEDE) estimated for the public hypothetical maximally exposed individual (MEI) is 5.7 E-6 millirem (mrem) per year for this fuel removal NOC. The abated TEDE conservatively is estimated to account for 2.9 E-9 mrem per year to the MEI.

Revitalizacija religije u sjeni naslijeđa liberalne zakonske regulative: stavovi o pobačaju

OpenAIRE

Goldberger, Goran

2009-01-01

U ovom tekstu se analiziraju stavovi ispitanika o zakonskom reguliranju pobačaja u Hrvatskoj, koje smo ukrštali s religijskom samoidentifikacijom i praksom te sociodemografskim obilježjima ispitanika. Na taj način smo željeli ukazati na eventualnu prisutnost razlika u stavovima o pobačaju i zagovaranju opcije života ili opcije izbora, s obzirom na navedene karakteristike ispitanika. Polazeći od pretpostavke utjecaja konteksta društvenih promjena s početka 90-ih na stavove ...

Influence of climate variability on anchovy reproductive timing off northern Chile

Science.gov (United States)

Contreras-Reyes, Javier E.; Canales, T. Mariella; Rojas, Pablo M.

2016-12-01

We investigated the relationship between environmental variables and the Gonadosomatic Monthly Mean (GMM) index of anchovy (Engraulis ringens) to understand how the environment affects the dynamics of anchovy reproductive timing. The data examined corresponds to biological information collected from samples of the landings off northern Chile (18°21‧S, 24°00‧S) during the period 1990-2010. We used the Humboldt Current Index (HCI) and the Multivariate ENSO Index (MEI), which combine several physical-oceanographic factors in the Tropical and South Pacific regions. Using the GMM index, we studied the dynamics of anchovy reproductive timing at different intervals of length, specifically females with a length between 11.5 and 14 cm (medium class) and longer than 14 cm (large class). Seasonal Autoregressive Integrated Mobile Average (SARIMA) was used to predict missing observations. The trends of the environment and reproductive indexes were explored via the Breaks For Additive Season and Trend (BFAST) statistical technique and the relationship between these indexes via cross-correlation functions (CCF) analysis. Our results showed that the habitat of anchovy switched from cool to warm condition, which also influenced gonad development. This was revealed by two and three significant changes (breaks) in the trend of the HCI and MEI indexes, and two significant breaks in the GMM of each time series of anchovy females (medium and large). Negative cross-correlation between the MEI index and GMM of medium and large class females was found, indicating that as the environment gets warmer (positive value of MEI) a decrease in the reproductive activity of anchovy can be expected. Correlation between the MEI index and larger females was stronger than with medium females. Additionally, our results indicate that the GMM index of anchovy for both length classes reaches two maximums per year; the first from August to September and the second from December to January. The

Induction of lethal mutations in the x-chromosome of unirradiated Drosophila oocytes after fertilization by irradiated spermatozoa

International Nuclear Information System (INIS)

Shaposhnikov, M.V.; Zainullin, V.G.

2003-01-01

Full text: In primary study on Drosophila it was found that irradiated male X-chromosomes induce recessive lethals in unirradiated female homologues (Abeleva et al., 1961, Radiobiologya. 1:123-126). The same effects were obtained in Drosophila in some recent investigations. The mechanisms of these effects is unknown. However it may be responsible for low-dose radiation effects as it induce mutations in unirradiated DNA. We assume that this effect may be a result of activation of error prone repair in response to preliminary DNA lesions in irradiated chromosome. In this research we analyse the frequencies of the recessive lethal mutations in the X-chromosome of Drosophila females mated with irradiated Basc males. We used acute irradiation with a dose rate of 10 Gy. For testing our hypothesis we use the mus209 and mei-41 mutant females. Mus209 is a PCNA gene homologue and mei-41 is a homologue of ATM gene. These genes are involved in post-replication DNA repair which may be error prone repair in Drosophila. It was obtained the tendency to decreasing the mutation rate at the mei-41[D5] background and decreasing mutation rate in mus209[B1] background in comparison with wild type strains CS (p<0.05). The obtained results demonstrate the possible role of mus209[B1] and mei-41[D5] genes in the inducing of mutations in the unirradiated X-chromosome in the presence of irradiated homologue

Evaluation of a multiple-encounter in situ simulation for orientation of staff to a new paediatric emergency service: a single-group pretest/post-test study.

Science.gov (United States)

Davison, Michelle; Kinnear, Frances B; Fulbrook, Paul

2017-10-01

To assess the utility of a multiple-encounter in-situ (MEIS) simulation as an orientation tool for multidisciplinary staff prior to opening a new paediatric emergency service. A single-group pretest/post-test study was conducted. During the MEIS simulation, multidisciplinary staff with participant or observer roles managed eight children (mannequins) who attended triage with their parent/guardians (clinical facilitators) for a range of emergency presentations (structured scenarios designed to represent the expected range of presentations plus test various clinical pathways/systems). Participants were debriefed to explore clinical, systems and crisis-resource management issues. Participants also completed a pre-intervention and post-intervention questionnaire comprising statements about role confidence and orientation adequacy. Pre-test and post-test results were analysed using t-test and Wilcoxon signed rank test. Eighty-nine staff participated in the MEIS simulation, with the majority completing the pre-simulation and post-simulation questionnaire. There was a significant improvement in post-intervention versus pre-intervention Likert scores for role confidence and orientation adequacy (p=0.001 and orientation adequacy. Nearly all scenarios resulted in significant increases in participants' confidence levels. The MEIS simulation was of utility in orientation of staff, at least with respect to self-reported role confidence and orientation adequacy. Its effectiveness in practice or compared with other orientation techniques was not assessed, but it did identify several flaws in planned systems allowing remediation prior to opening.

Structural characterization of CdSe/ZnS quantum dots using medium energy ion scattering

Science.gov (United States)

Sortica, M. A.; Grande, P. L.; Radtke, C.; Almeida, L. G.; Debastiani, R.; Dias, J. F.; Hentz, A.

2012-07-01

In the present work, we have analyzed CdSe/ZnS core-shell quantum dots by medium energy ion scattering (MEIS), which is a powerful technique to explore the synthesis, formation, stability, and elemental distribution of such core-shell structures, along with other auxiliary analytical techniques. By comparing different quantum-dot structural models spectra with the experimental MEIS data, we were able to obtain some sample structural information. We found that, despite the well known non stoichiometric Cd:Se ratio, the core is stoichiometric, and there is an excess of cadmium distributed in the shell.

Technical Knowledge, Cultural Practices and Social Boundaries: Wan-Nan Scholars and the Recasting of Jesuit Astronomy, 1600-1800

Science.gov (United States)

Chu, Ping-Yi.

Taking four Wan-nan Confucian scholars--Yang Kuang -hsien, Mei Wen-ting, Chiang Yung and Tai Chen--as examples, this dissertation studies how an immigrant Jesuit scientific community built and defended itself in a specialized institutional niche located at the Ch'ing court and how a defeated Chinese scientific tradition successfully survived by occupying a broader cultural space, with the Manchu emperor in between. Special attention is paid to how these four Confucian scholars constructed social boundaries between the Chinese and the Westerners in their astronomical discourses and how they domesticated Western astronomy in order to fit the Chinese cultural conditions situated in the power structure built by the Manchus. This inquiry begins with a brief introduction of Wan-nan and the Wan-nan school. I then discuss how the Jesuits legitimated their knowledge during the Ming -Ch'ing transition, and how Jesuit astronomy was situated within the power nexus between the Confucian literati and the emperors. The next chapter focuses on Yang Kuang-hsien and his challenges to the Jesuits. I examine his strategies and the power structure in which Yang carried out his challenge to the Jesuits. The fourth and fifth chapters investigate how Mei Wen-ting restructured the relationship between Confucianism and astronomy. The former chapter focuses on Mei's social networking and his ambivalence towards the Ming and Ch'ing dynasties, on the one hand, and towards Chinese and Western learning on the other. The latter chapter deals with how Mei Wen-ting recast Chinese astronomical tradition and Confucianism. In the sixth chapter, I will compare the fame of Chiang Yung and Tai Chen in order to demonstrate how astronomy was practiced in evidential studies after Mei Wen-ting, and how evidential studies itself conveyed an ideological construction of the other. Through integrating Western astronomy with indigenous tradition while exorcising the otherness contained within the cultural package

S, M, L, XL: SEBUAH PANDANGAN PERALIHAN MODERN URBANISME MENUJU POSTMODERN URBANISME

Directory of Open Access Journals (Sweden)

, Affrilyno

2015-01-01

architecture and urbanism like instead of denial of complexity, lack of control, opposition, contradiction, and bigness, Koolhaas embrace these conditions and declare them as the starting point for their projects. The urban context specifically, Koolhaas stated, no longer can be controlled in the 'classical' manner of Modernism. These issues serve as the structural means to accommodate what cannot be controlled. They are the new instruments of urbanism and architecture. REFERENCES ADIP. Rethinking Berlin | a city and its river. ADIP. Urban and Architectural Research. Diakses dari http://www.adip.tu-berlin.de/wp-content/uploads/2010/10/adipmagazine_01__preview.pdf. 22 Mei 2011. Antonio Negri. 2009. On Rem Koolhaas. Diakes dari http://www.haraldpeterstrom.com/content/5.pdfs/Antonio%20Negri%20%E2%80%93%20On%20Rem%20Koolhaas.pdf. 22 Mei 2011. Archdaily. Seattle Public Library”. Diakses dari http://www. archdaily.com/11651/seattle-central-library-oma-lmn/. 30 Mei 2011 Henri Achten. Review: S, M, L, XL, O.M.A.,Rem Koolhaas,Bruce Mau,1995. Diakses dari http://lava.ds.arch. tue.nl/books/ koolhaas.html. 22 Mei 2011. John Rajchman. Thinking big - Dutch architect Rem Koolhaas - Interview". ArtForum. Diakses dari FindArticles.com,http://findarticles.com/p/articles/mi_m0268/is_n4_v33/ai_16547724/. 22 Mei 2011. Joshua Ramus. 2004. Seattle Public. In Rem Koolhaas/ OMA, Content, Taschen, hal. 138-149. Lara Schrijver. 2008. OMA as tribute to OMU:   exploring resonance in the work of Koolhaas and Ungers. The Journal of Architecture, Volume 13, No. 3. Diakses dari http://www.tandfonline.com/doi/abs/10.1080/13602360802214927#.VMmnwi42uu8. 22 Mei 2011. Mark Gilbert. 2003. On Beyond Koolhaas : Identity, Sameness and the Crisis of City Planning. Diakses dari http://www.uibk.ac.at/wuv/pdf/ehem/gilbert_city.pdf. 22 Mei 2011. Notablebiographies. Rem Koolhaas. Diakses dari http://www. notablebiographies.com/news/Ge-La/Koolhaas-Rem.html. 31 Mei 2011. O.M.A/Rem Koolhas. Seatle Public Library

Ranjivost obala otoka Raba zbog rasta razine mora

OpenAIRE

Ružić, Igor; Benac, Čedomir

2016-01-01

U ovom je radu opisana ranjivost obala otoka Raba koja može biti prouzročena prognoziranim porastom razine mora do kraja 21. stoljeća. Opisane su posljedice koju taj prirodni fenomen može prouzročiti. Analizirana su tri scenarija pojava visoke razine mora: kod stagnacije globalne morske razine te kod porasta za 30 i 60 cm. Analize su napravljene na topografskim kartama mjerila 1:5000. Ustanovljene su najugroženije urbanizirane obalne zone: uvala Sv. Eufemija, luka grada Raba, Supetarska Draga...

Radionuclide air emissions report for the Hanford Site. Calendar year 1997

International Nuclear Information System (INIS)

Gleckler, B.P.; Rhoads, K.

1998-01-01

This report documents radionuclide air emission from the Hanford Site in 1997, and the resulting effective dose equivalent to the maximally exposed member of the public, referred to as the MEI. The report has been prepared in accordance with reporting requirements in the Code of Federal Regulations, Title 40, Protection of the Environment, Part 61, National Emissions Standards for Hazardous Air Pollutants, Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities. This report has also been prepared in accordance with the reporting requirements of the Washington Administrative Code Chapter 246-247, Radiation Protection-Air Emissions. The effective dose equivalent to the MEI from the Hanford Site's 1997 point source emissions was 1.2 E-03 mrem (1.2 E-05 mSv), which is well below the 40 CFR 61 Subpart H regulatory limit of 10 mrem/yr. Radon and thoron emissions, exempted from 40 CFR 61 Subpart H, resulted in an effective dose equivalent to the MEI of 2.5 E-03 mrem (2.5 E-05 mSv). The effective dose equivalent to the MEI attributable to diffuse and fugitive emissions was 2.2 E-02 mrem (2.2 E-04 mSv). The total effective dose equivalent from all of the Hanford Site's air emissions was 2.6 E-02 mrem (2.6 E-04 mSv). The effective dose equivalent from all of the Hanford Site's air emissions is well below the Washington Administrative Code, Chapter 246-247, regulatory limit of 10 mrem/yr

Radioactive Air Emmission Notice of Construction (NOC) for the Waste Receiving and Processing Facility (WRAP)

Energy Technology Data Exchange (ETDEWEB)

MENARD, N.M.

2000-12-01

This document serves as a notice of construction (NOC) pursuant to the requirements of Washington Administrative Code (WAC) 246-247-060, and as a request for approval to modify pursuant to 40 Code of Federal Regulations (CFR) 61.07 for the Waste Receiving and Processing (WRAP) Facility. The rewrite of this NOC incorporates all the approved revisions (Sections 5.0, 6.0, 8.0, and 9.0), a revised potential to emit (PTE) based on the revised maximally exposed individual (MEI) (Sections 8.0, 10.0, 11.0, 12.0, 13.0, 14.0, and 15.0), the results of a study on fugitive emissions (Sections 6.0, 10.0, and 15.0), and reflects the current operating conditions at the WRAP Facility (Section 5.0). This NOC replaces DOE/RL-93-15 and DOE/RL-93-16 in their entirety. The primary function of the WRAP Facility is to examine, assay, characterize, treat, verify, and repackage radioactive material and mixed waste. There are two sources of emissions from the WRAP Facility: stack emissions and fugitive emissions. The stack emissions have an unabated total effective dose equivalent (TEDE) estimate to the hypothetical offsite MEI of 1.13 E+02 millirem per year. The abated TEDE for the stack emissions is estimated at 5.63 E-02 millirem per year to the MEI. The fugitive emissions have an unabated TEDE estimate to the hypothetical offsite MEI of 5.87 E-04. There is no abatement for the fugitive emissions.

Radioactive Air Emmission Notice of Construction (NOC) Application for the Waste Receiving and Processing Facility (WRAP)

International Nuclear Information System (INIS)

MENARD, N.M.

2000-01-01

This document serves as a notice of construction (NOC) pursuant to the requirements of Washington Administrative Code (WAC) 246-247-060, and as a request for approval to modify pursuant to 40 Code of Federal Regulations (CFR) 61.07 for the Waste Receiving and Processing (WRAP) Facility. The rewrite of this NOC incorporates all the approved revisions (Sections 5.0, 6.0, 8.0, and 9.0), a revised potential to emit (PTE) based on the revised maximally exposed individual (MEI) (Sections 8.0, 10.0, 11.0, 12.0, 13.0, 14.0, and 15.0), the results of a study on fugitive emissions (Sections 6.0, 10.0, and 15.0), and reflects the current operating conditions at the WRAP Facility (Section 5.0). This NOC replaces DOE/RL-93-15 and DOE/RL-93-16 in their entirety. The primary function of the WRAP Facility is to examine, assay, characterize, treat, verify, and repackage radioactive material and mixed waste. There are two sources of emissions from the WRAP Facility: stack emissions and fugitive emissions. The stack emissions have an unabated total effective dose equivalent (TEDE) estimate to the hypothetical offsite MEI of 1.13 E+02 millirem per year. The abated TEDE for the stack emissions is estimated at 5.63 E-02 millirem per year to the MEI. The fugitive emissions have an unabated TEDE estimate to the hypothetical offsite MEI of 5.87 E-04. There is no abatement for the fugitive emissions

Radionuclide air emissions report for the Hanford Site -- calendar year 1997

Energy Technology Data Exchange (ETDEWEB)

Gleckler, B.P.; Rhoads, K.

1998-06-17

This report documents radionuclide air emission from the Hanford Site in 1997, and the resulting effective dose equivalent to the maximally exposed member of the public, referred to as the MEI. The report has been prepared in accordance with reporting requirements in the Code of Federal Regulations, Title 40, Protection of the Environment, Part 61, National Emissions Standards for Hazardous Air Pollutants, Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities. This report has also been prepared in accordance with the reporting requirements of the Washington Administrative Code Chapter 246-247, Radiation Protection-Air Emissions. The effective dose equivalent to the MEI from the Hanford Site`s 1997 point source emissions was 1.2 E-03 mrem (1.2 E-05 mSv), which is well below the 40 CFR 61 Subpart H regulatory limit of 10 mrem/yr. Radon and thoron emissions, exempted from 40 CFR 61 Subpart H, resulted in an effective dose equivalent to the MEI of 2.5 E-03 mrem (2.5 E-05 mSv). The effective dose equivalent to the MEI attributable to diffuse and fugitive emissions was 2.2 E-02 mrem (2.2 E-04 mSv). The total effective dose equivalent from all of the Hanford Site`s air emissions was 2.6 E-02 mrem (2.6 E-04 mSv). The effective dose equivalent from all of the Hanford Site`s air emissions is well below the Washington Administrative Code, Chapter 246-247, regulatory limit of 10 mrem/yr.

Performance and carcass characteristics of steers fed with two levels of metabolizable energy intake during summer and winter season.

Science.gov (United States)

Arias, R A; Keim, J P; Gandarillas, M; Velásquez, A; Alvarado-Gilis, C; Mader, T L

2018-05-22

Climate change is producing an increase on extreme weather events around the world such as flooding, drought and extreme ambient temperatures impacting animal production and animal welfare. At present, there is a lack of studies addressing the effects of climatic conditions associated with energy intake in finishing cattle in South American feed yards. Therefore, two experiments were conducted to assess the effects of environmental variables and level of metabolizable energy intake above maintenance requirements (MEI) on performance and carcass quality of steers. In each experiment (winter and summer), steers were fed with 1.85 or 2.72 times of their requirements of metabolizable energy of maintenance. A total of 24 crossbred steers per experiment were used and located in four pens (26.25 m2/head) equipped with a Calan Broadbent Feeding System. Animals were fed with the same diet within each season, varying the amount offered to adjust the MEI treatments. Mud depth, mud scores, tympanic temperature (TT), environmental variables, average daily gain, respiration rates and carcass characteristics plus three thermal comfort indices were collected. Data analysis considered a factorial arrangement (Season and MEI). In addition, a repeated measures analysis was performed for TT and respiration rate. Mean values of ambient temperature, solar radiation and comfort thermal indices were greater in the summer experiment as expected (Pcarcass characteristics were affected by season but not by the level of MEI. Finally, due to the high variability of data as well as the small number of animals assessed in these experiments, more studies on carcass characteristics under similar conditions are required.

Kohus elab meis endis edasi, kõik elab meis edasi / Pärt Uusberg ; interv. Piret Linnamägi

Index Scriptorium Estoniae

Uusberg, Pärt

2008-01-01

Coca-Cola Plazas kuulutati välja uue filmiauhinna "Hää film 2007" laureaadid. Nominentide hulgas oli ka Raplamaa noormees Pärt Uusberg, kes mängis filmis "Klass" üht peaosalist. Endast, filmist, koolielust, filmi püstitatud teemadest

Imaging flaws in thin metal plates using a magneto-optic device

Science.gov (United States)

Wincheski, B.; Prabhu, D. R.; Namkung, M.; Birt, E. A.

1992-01-01

An account is given of the capabilities of the magnetooptic/eddy-current imager (MEI) apparatus in the case of aging aircraft structure-type flaws in 2024-T3 Al alloy plates. Attention is given to images of cyclically grown fatigue cracks from rivetted joints in fabricated lap-joint structures, electrical discharge machining notches, and corrosion spots. Although conventional eddy-current methods could have been used, the speed and ease of MEI's use in these tests is unmatched by such means. Results are displayed in real time as a test piece is scanned, furnishing easily interpreted flaw images.

Prirodna baština otoka Mljeta – temelj razvoja zdravstvenog turizma

OpenAIRE

Nodilo, Marija

2012-01-01

Otok Mljet poznat je po svojoj prirodnoj baštini: morskim jezerima, šumama crnike i alepskog bora, blatinama, klifovitim obalama, pješčanim uvalama, špiljama, bogatstvu mora i podmorja, prirodnim lukama, izvorima pitke vode, endemičnim i ljekovitim biljkama. Šume i vegetacija sačuvane su zahvaljujući svijesti o nužnosti zaštite ovog prirodnog krajolika, koji ostavlja snažan dojam na posjetitelja. Stoga je prostor jedne trećine otoka Mljeta 1960. proglašen Nacionalnim parkom, pa su na taj n...

Investigation of NPK in fertilized and unfertilized vegetables

International Nuclear Information System (INIS)

Deeba, F.; Butt, M.T.; Iqubal, K.; Shafiq, T.

2010-01-01

Contents of selected minerals and moisture in Ridge Gourd, Gourd and Brinjal vegetables, collected from house and market of different localities, were determined. In house vegetables from kitchen garden of PCSIR colony the moisture contents were high (90%) as compared to market vegetables of Taj Bagh, Railway workshop Mandy and Singpura Lahore Mandy was 87%, 86.5% and 87.5% respectively. Regarding nitrogen, nitrate, nitrite, phosphate, sodium and potassium was high in market vegetables as compared to house samples due to the accumulation of nutrients in soil and crop. (author)

Delimitacija i demarkacija vanjskih granica Republike Hrvatske

Directory of Open Access Journals (Sweden)

Vladimir-Đuro Degan

2015-09-01

Full Text Available Daje se sumaran prikaz delimitacije i demarkacije granica Hrvatske sa svim njezinim susjedima s preporukom da se taj odgovoran posao ne zanemari. Postignuti privremeni ili nerealizirani sporazumi ocjenjuju se temeljem pravilâ kodificiranih u Bečkoj konvenciji o pravu ugovora iz 1969. godine. Ali valja voditi računa i o drugim međunarodnim obvezama poput one iz Beogradske dunavske konvencije iz 1948. i prava fizičkih i pravnih osoba na uživanje njihovih nekretnina koje se nađu na drugoj strani granice.

Ekonomičnost preventivnog zatvaranja fisura (cost - benefit analiza)

OpenAIRE

Maras, Angelina

1989-01-01

U radu su prikazana dvogodišnja istraživanja na ukupno 216 prvih trajnih kutnjaka poslije preventivnog postupka zatvaranja jamica i fisura radi provjere djelotvornosti te metode i njezine ekonomičnosti. Ekonomska analiza »korist-troškovi« (benefit-cost) pokazuje da je taj omjer (k /t = 1,87) skoro dvostruko skuplji kad se stavlja jednoplošni amalgamski ispun nego ako je izvršeno zatvaranje fisura na žvačnim plohama trajnih kutnjaka bilo da se radi o utrošku vremena ili novčanom izno...

Istraživanje mogućnosti upotrebe stabljika biljki Isatis tinctoria i Isatis buschiana kao sirovine za proizvodnju celuloze i papira

OpenAIRE

Comlekcioglu, Nazan; Tutus, Ahmet; Cicekler, Mustafa; Canak, Asuman; Zengin, Gulsen

2016-01-01

U radu su istražene mogućnosti upotrebe stabljike biljaka Isatis tinctoria i Isatis buschiana kao sirovine za proizvodnju celuloze i papira. Određeni su kemijski sastav i morfološka svojstva stabljike. Sadržaj lignina u stabljici I. tinctoria bio je 23,9 %, a u stabljici I. buschiana 19,9 %. U stabljici I. tinctoria utvrđen je udjel alfa-celuloze od 48,5 %, a u stabljici I. buschiana taj je postotak iznosio 32,9 %. Izmjereni su duljina i promjer vlakanaca, promjer pore i debljina stanične sti...

KARAKTERISTIKE I DJELOVANJE NASILJA U VIDEOIGRAMA

OpenAIRE

Valković, Jerko

2009-01-01

Nasilje u medijima nije samo preslika nasilja prisutnog u životu pojedinaca ili društva jer treba uvijek imati u vidu da medijska posredovanje nasilja koje se prezentim dobiva nove funkcije i novo značenje. Govor o utjecaju nasilja u medijima pretpostavlja razumijevanje funkcioniranja i specifičnosti samoga medija, značenja koje taj medij ima za pojedinca i širi društveni ambijent te, na osobit način, poznavanje dinamike koja se razvija prigodom konzumiranja medija. Jedno je od važnih obiljež...

International public relations and public diplomacy on the example of the State of Israel

OpenAIRE

Nikić, Petra

2016-01-01

Država Izrael u svijetu je prepoznata po višetisućljetnoj židovskoj tradiciji i povijesti. Osim bogate kulture, prožete bliskoistočnim elementima, ali i onima doseljenika iz raznih zapadnih zemalja, Izrael uživa poseban imidž na međunarodnoj pozornici. Taj pak imidž ovisi o više faktora – s jedne strane Izrael predstavlja multikulturalnu zemlju poželjnu kao turističku destinaciju ili pak zemlju za ekonomske i tehnološke inovacije, dok s druge Izrael biva predstavljen u negativnom kontekstu ka...

Characterization of TALE genes expression during the first lineage segregation in mammalian embryos.

Science.gov (United States)

Sonnet, Wendy; Rezsöhazy, Rene; Donnay, Isabelle

2012-11-01

Three amino acid loop extension (TALE) homeodomain-containing transcription factors are generally recognized for their role in organogenesis and differentiation during embryogenesis. However, very little is known about the expression and function of Meis, Pbx, and Prep genes during early development. In order to determine whether TALE proteins could contribute to the early cell fate decisions in mammalian development, this study aimed to characterize in a systematic manner the pattern of expression of all Meis, Pbx, and Prep genes from the precompaction to blastocyst stage corresponding to the first step of cell differentiation in mammals. To reveal to what extent TALE genes expression at these early stages is a conserved feature among mammals, this study was performed in parallel in the bovine and mouse models. We demonstrated the transcription and translation of TALE genes, before gastrulation in the two species. At least one member of Meis, Pbx, and Prep subfamilies was found expressed at the RNA and protein levels but different patterns of expression were observed between genes and between species, suggesting specific gene regulations. Taken together, these results suggest a previously unexpected involvement of these factors during the early development in mammals. Copyright © 2012 Wiley Periodicals, Inc.

Model Effectiviteit Instrumenten-Energiebesparing Industrie (MEI-Energie)

NARCIS (Netherlands)

Wijk JJ van; Engelen RFJM; Ros JPM; LAE

2001-01-01

Within the context of the Kyoto Protocol insight into industrial energy savings and the influence of policy instruments is desirable, both for the past and the future. By virtue of its legal central policy analysis function, the RIVM is currently developing an energy-saving model for industrial

Poređenje snage za jednu i dve kontrarotirajuće hidro turbine u Venturijevoj cevi - II deo / Comparison of power for one and two contra-rotating hydro turbines in a Venturi tube: Part II

Directory of Open Access Journals (Sweden)

Mirko S. Kozić

2009-10-01

Full Text Available U prvom delu rada izloženi su rezultati istraživanja koja daju priraštaj snage dobijen sa dve kontrarotirajuće hidroturbine u poređenju sa snagom jedne turbine, smeštene u Venturijevoj cevi, a koje se obrću sa n = 50 o/min. Izvršena su istraživanja koja je trebalo da daju odgovor na pitanje da li se može dobiti veći priraštaj snage sa povećanjem broja obrtaja. U drugom delu rada prikazani su rezultati za jednu i dve kontrarotirajuće turbine pri najvećem broju obrtaja pri kojem se ne javlja kavitacija na lopaticama. Rezultati su dobijeni numeričkim simulacijama uz korišćenje softvera koji rešava usrednjene Navije-Stoksove jednačine. / In the first part of the paper, the results of the research are presented, giving the increment of the power obtained with two contra-rotating hydro turbines, compared to one turbine, placed in a Venturi tube and rotating at 50 rpm. Since a small increment of power is obtained, research was carried out in order to give an answer to the question whether a larger increment of power could be obtained by increasing a number of revolutions per minute. In the second part of the paper, the results are shown for one and two contra-rotating turbines at the highest revolution at which no cavitation appears on the blades. The results are obtained with numerical simulations using software for solving Navier-Stokes equations.

Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation

International Nuclear Information System (INIS)

Richardson, Terrilyn A.; Klaassen, Curtis D.

2010-01-01

Microsomal enzyme inducers (MEI) that increase UDP-glucuronosyltransferases (UGTs) are thought to increase glucuronidation of thyroxine (T 4 ), thus reducing serum T 4 , and subsequently increasing thyroid stimulating hormone (TSH). Ugt1a1 and Ugt1a6 mediate T 4 glucuronidation. Therefore, this experiment determined the involvement of Ugt1a enzymes in increased T 4 glucuronidation, decreased serum T 4 , and increased TSH after MEI treatment. Male Wistar and Ugt1a-deficient Wistar (Gunn) rats were fed a control diet or diet containing pregnenolone-16α-carbonitrile (PCN; 800 ppm), 3-methylcholanthrene (3-MC; 200 ppm), or Aroclor 1254 (PCB; 100 ppm) for 7 days. Serum T 4 , triiodothyronine (T 3 ), and TSH concentrations, hepatic T 4 /T 3 glucuronidation, and thyroid histology and follicular cell proliferation were investigated. PCN, 3-MC, and PCB treatments decreased serum T 4 , whereas serum T 3 was maintained in both Gunn and Wistar rats (except for PCB treatment). TSH was increased in Wistar and Gunn rats after PCN (130 and 277%) or PCB treatment (72 and 60%). T 4 glucuronidation in Wistar rats was increased after PCN (298%), 3-MC (85%), and PCB (450%), but was extremely low in Gunn rats, and unchanged after MEI. T 3 glucuronidation was increased after PCN (121%) or PCB (58%) in Wistar rats, but only PCN increased T 3 glucuronidation in Gunn rats (43%). PCN treatment induced thyroid morphological changes and increased follicular cell proliferation in both strains. These data demonstrate that T 4 glucuronidation cannot be increased in Ugt1a-deficient Gunn rats. Thus, the decrease in serum T 4 , increase in TSH, and increase in thyroid cell proliferation after MEI are not dependent on increased T 4 glucuronidation, and cannot be attributed to Ugt1a enzymes.

Content of 4(5-methylimidazole, caffeine and chlorogenic acid in commercial coffee brands

Directory of Open Access Journals (Sweden)

Thi Thanh Dieu Phan

2015-05-01

Full Text Available Content of 4(5-methylimidazole (4-MeI, caffeine and chlorogenic acid in commercial coffee brands were determined using high-performance liquid chromatography (HPLC with UV DAD and MS detectors. Positive ion ESI mass spectra of the 4-MeI standard yielded intense signals corresponding to [M+H]+ (83.0604 and [2M+H]+ ions (165.1115. Also, adducts of 4-MeI with acetonitrile from mobile were detected - [M+ACN]+ ions (124.0849. The LOD of 2.5 ng mL-1 and LOQ of 8.4 ng.mL-1 were calculated according to the following formulas: LOD = 3.SD/S, and LOQ = 10.SD/S, where S is the slope of the calibration curve and SD is the standard deviation of the noise. The caffeine content was compared to the results of the standard addition, 1st derivative and liquid-liquid extraction spectrophotometry. 4-MeI was in tens µg g-1 in the Vietnamese coffees while in units µg.g-1 in all Czech and Brazilian coffees (<2.4 µg.g-1 and <4.9 µg.g-1, respectively. The results for caffeine were within the documented range (0.31 - 2.20% in all coffee samples. The lower content of caffeine and chlorogenic acid was observed in Vietnamese coffees. All the methods used for determination of caffeine in the Czech and Brazilian coffees gave acceptable precision and accuracy. However, there were significant differences in the results in Vietnamese coffees. The caffeine extractability (100 °C, 3 min brewing almost reached 100% in Czech and Brazilian coffees, while it was less than 90% in Vietnamese coffees. The Czech and Brazilian coffees tend to produce more caffeine in brews than the Vietnamese coffee because of the different composition of blends and the particle size degree.  

CSI cardiac prevent 2015

Directory of Open Access Journals (Sweden)

S Ramakrishnan

2015-01-01

Full Text Available The CSI Cardiac Prevent 2015 was held at Hotel Taj Palace, New Delhi, on September 25-27, 2015. The major challenge was to create interest among cardiologists and physicians on preventive cardiology, a neglected area. The theme of the conference was "Innovations in Heart Disease Prevention.′′ This conference included "CSI at WHF Roadmap Workshop, Inauguration Ceremony, scientific program, plenary sessions, Nursing/Dietician track, Industry Exhibition, Social Events," Great India blood pressure Survey, and CSI Smart Heart App. A total of 848 delegates/faculties attended this conference against a total of 1140 people registered for the meeting.

PIXE analysis on Maya blue in Prehispanic and colonial mural paintings

Science.gov (United States)

Sánchez del Río, M.; Martinetto, P.; Solís, C.; Reyes-Valerio, C.

2006-08-01

Particle induced X-ray emission (PIXE) experiments have been carried out at the AGLAE facility (Paris) on several mural samples containing Maya blue from different Prehispanic archaeological sites (Cacaxtla, El Tajín, Tamuin, Santa Cecilia Acatitlán) and from several colonial convents in the Mexican plateau (Jiutepec, Totimehuacán, Tezontepec and Cuauhtinchán). The analysis of the concentration of several elements permitted to extract some information on the technique used for painting the mural, usually fresco. Principal component analysis permitted to classify the samples into groups. This grouping is discussed in relation to geographic and historic data.

The Mausoleum Of Humayun

Directory of Open Access Journals (Sweden)

Rahimov Laziz Abduazizovich

2015-08-01

Full Text Available Humayuns Tomb is the first mausoleum which was built by Baburids in India. Also the worlds most well-known mausoleum Taj Mahal has been inspired by this Tomb. However until now this magnificent mausoleums commander and which architectural style was used is still debatable. In this research we will try to identify the commander of Humayuns Tomb and clarify which architectural styles was used and from which traditions this heritages was inspired. Moreover we analyze the main characters innovations of the Humayuns Tomb and identify later impacts for developing mausoleums of this type.

Brightness enhancement of plasma ion source by utilizing anode spot for nano applications

International Nuclear Information System (INIS)

Park, Yeong-Shin; Lee, Yuna; Chung, Kyoung-Jae; Hwang, Y. S.; Kim, Yoon-Jae; Park, Man-Jin; Moon, Dae Won

2012-01-01

Anode spots are known as additional discharges on positively biased electrode immersed in plasmas. The anode spot plasma ion source (ASPIS) has been investigated as a high brightness ion source for nano applications such as focused ion beam (FIB) and nano medium energy ion scattering (nano-MEIS). The generation of anode spot is found to enhance brightness of ion beam since the anode spot increases plasma density near the extraction aperture. Brightness of the ASPIS has been estimated from measurement of emittance for total ion beam extracted through sub-mm aperture. The ASPIS is installed to the FIB system. Currents and diameters of the focused beams with/without anode spot are measured and compared. As the anode spot is turned on, the enhancement of beam current is observed at fixed diameter of the focused ion beam. Consequently, the brightness of the focused ion beam is enhanced as well. For argon ion beam, the maximum normalized brightness of 12 300 A/m 2 SrV is acquired. The ASPIS is applied to nano-MEIS as well. The ASPIS is found to increase the beam current density and the power efficiency of the ion source for nano-MEIS. From the present study, it is shown that the ASPIS can enhance the performance of devices for nano applications.

Hanford Site Air Operating Permit Application - Supplemental Information (Supplement 1, Volumes 1 thru 3)

International Nuclear Information System (INIS)

CURN, B.L.

2000-01-01

This report documents radionuclide air emissions from the Hanford Site in 1998 and the resulting effective dose equivalent to the maximally exposed individual (MEI) member of the public. The report has been prepared in accordance with the Code of Federal Regulations, Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (40 CFR 61), Subpart H: ''National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities,'' and with the Washington Administrative Code Chapter 246247, Radiation Protection - Air Emissions. The federal regulations in 40 CFR 61, Subpart H, require the measurement and reporting of radionuclides emitted from Department of Energy facilities and the resulting offsite dose from those emissions. A standard of 10 mrem/yr effective dose equivalent (EDE) is imposed on them. The EDE to the MEI due to routine emissions in 1998 from Hanford Site point sources was 1.3 E-02 mrem (1.3 E-04 mSv). which is 0.13 percent of the federal standard. Chapter 246-247 of the Washington Administrative Code (WAC) requires the reporting of radionuclide emissions from all Department of Energy Hanford Site sources. The state has adopted into these regulations the 40 CFR 61 standard of 10 mrem/yr EDE. The EDE to the MEI attributable to diffuse and fugitive radionuclide air emissions from the Hanford Site in 1998 was 2.5 E-02 mrem (2.S E-04 mSv). This dose added to the dose from point sources gives a total for all sources of 3.8 E-02 mrem/yr (3.8 E-04 mSv) EDE. which is 0.38 percent of the 10 mrem/yr standard. An unplanned release on August 26, 1998, in the 300 Area of the Hanford Site resulted in a potential dose of 4.1 E-02 mrem to a hypothetical individual at the nearest point of public access to that area. This hypothetical individual was not the MEI since the wind direction on the day of the release was away from the MEI residence. The potential dose from the unplanned event

Radionuclide Air Emissions Report for the Hanford Site Calendar year 1998

Energy Technology Data Exchange (ETDEWEB)

DIEDIKER, L.P.

1999-06-15

This report documents radionuclide air emissions from the Hanford Site in I998 and the resulting effective dose equivalent to the maximally exposed individual (MEI) member of the public. The report has been prepared in accordance with the Code of Federal Regulations, Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (40 CFR SI), Subpart H, ''National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities,'' and with the Washington Administrative Code Chapter 246-247, Radiation Protection--Air Emissions. The federal regulations in 40 CFR 61, Subpart H; require the measurement and reporting of radionuclides emitted from Department of Energy facilities and the resulting offsite dose from those emissions. A standard of 10 mrem/yr effective dose equivalent (EDE) is imposed on them. The EDE to the MEI due to routine emissions in 1998 from Hanford Site point sources was 1.3 E-02 mrem (1.3 E-04 mSv), which is 0.13 percent of the federal standard. Chapter 246-247 of the Washington Administrative Code (WAC) requires the reporting of radionuclide emissions from all Department of Energy Hanford Site sources. The state has adopted into these regulations the 40 CFR 61 standard of 10 mrem/yr EDE. The EDE to the MEI attributable to diffuse and fugitive radionuclide air emissions from the Hanford Site in 1998 was 2.5 E-02 mrem (2.5 E-04 mSv). This dose added to the dose from point sources gives a total for all sources of 3.8 E-02 mrem/yr (3.8 E-04 mSv) EDE, which is 0.38 percent of the 10 mrem/yr standard. An unplanned release on August 26, 1998, in the 300 Area of the Hanford Site resulted in a potential dose of 4.1 E-02 mrem to a hypothetical individual at the nearest point of public access to that area. This hypothetical individual was not the MEI since the wind direction on the day of the release was away from the MEI residence. The potential dose from

Hanford Site Air Operating Permit Application Supplemental Information [Sec 1 Thru 5] Vol 1 Thru 3 Appendices A Thru C

Energy Technology Data Exchange (ETDEWEB)

CURN, B.L.

2000-05-01

This report documents radionuclide air emissions from the Hanford Site in 1998 and the resulting effective dose equivalent to the maximally exposed individual (MEI) member of the public. The report has been prepared in accordance with the Code of Federal Regulations, Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (40 CFR 61), Subpart H: ''National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities,'' and with the Washington Administrative Code Chapter 246247, Radiation Protection - Air Emissions. The federal regulations in 40 CFR 61, Subpart H, require the measurement and reporting of radionuclides emitted from Department of Energy facilities and the resulting offsite dose from those emissions. A standard of 10 mrem/yr effective dose equivalent (EDE) is imposed on them. The EDE to the MEI due to routine emissions in 1998 from Hanford Site point sources was 1.3 E-02 mrem (1.3 E-04 mSv). which is 0.13 percent of the federal standard. Chapter 246-247 of the Washington Administrative Code (WAC) requires the reporting of radionuclide emissions from all Department of Energy Hanford Site sources. The state has adopted into these regulations the 40 CFR 61 standard of 10 mrem/yr EDE. The EDE to the MEI attributable to diffuse and fugitive radionuclide air emissions from the Hanford Site in 1998 was 2.5 E-02 mrem (2.S E-04 mSv). This dose added to the dose from point sources gives a total for all sources of 3.8 E-02 mrem/yr (3.8 E-04 mSv) EDE. which is 0.38 percent of the 10 mrem/yr standard. An unplanned release on August 26, 1998, in the 300 Area of the Hanford Site resulted in a potential dose of 4.1 E-02 mrem to a hypothetical individual at the nearest point of public access to that area. This hypothetical individual was not the MEI since the wind direction on the day of the release was away from the MEI residence. The potential dose from

Microchannel Reactors for ISRU Applications Using Nanofabricated Catalysts, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Makel Engineering, Inc. (MEI) and USRA propose to develop microchannel reactors for In-Situ Resources Utilization (ISRU) using nanofabricated catalysts. The proposed...

Microchannel Methanation Reactors Using Nanofabricated Catalysts, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Makel Engineering, Inc. (MEI) and the Pennsylvania State University (Penn State) propose to develop and demonstrate a microchannel methanation reactor based on...

THE NOTION OF HIERARCHY: THE ‘PARCHIN KARI’ PROGRAMME AT THE TAJ MAHAL

Directory of Open Access Journals (Sweden)

Thalia Kennedy

2007-03-01

visitors to the mausoleum. The paper addresses three main issues: the decorative technique and its context and symbolism; a description of the gemstone and ornamental stone programme with a focus on motif, material and location; and the relationship between that programme and the concept of hierarchical organisation in its enhancement of the visual and spatial effects.

Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença Extra-intestinal manifestations Crohn disease and ulcerative rectocolitis: prevalence na correlation with diagnosis, extension, activity, disease evolution time

Directory of Open Access Journals (Sweden)

Erodilho Sande Mota

2007-12-01

Full Text Available INTRODUÇÃO: Existe uma grande prevalência de manifestações extra-intestinais(MEI em portadores de doença de Crohn(DC e de retocolite ulcerativa(RCU, variando de 24 a 65%. OBJETIVO: Determinar a prevalência de MEI em RCU e DC, correlacionando com diagnóstico do tipo de doença inflamatória intestinal, extensão, tempo de evolução e atividade da doença. MÉTODOS: Mil pacientes foram avaliados no Hospital das Clínicas da FMUSP no período de 1984 a 2004. Foram estudadas manifestações articulares, dermatológicas, oftalmológicas, urológicas, hepáticas, pulmonares e vasculares. RESULTADOS: Foram estudados 468 pacientes com DC(46,8% e 532 com RCU(53,2%. Encontrados 627 pacientes (59,2% com RCU e 66,7% com DC com pelo menos uma forma de MEI. A média de tempo de doença dos pacientes com MEI foi de 10 anos. As MEI foram mais freqüentes após o início dos sintomas intestinais. CONCLUSÕES: Tanto na RCU quanto na DC,quanto maior a extensão da doença no cólon, maior a incidência de MEI. As manifestações urológicas foram mais freqüentes na DC. As manifestações articulares e dermatológicas foram mais prevalentes no sexo feminino nos dois grupos. Manifestações hepáticas foram mais prevalentes na DC. As manifestações articulares, dermatológicas e vasculares tiveram correlação com a atividade da doença intestinal em ambos os grupos.INTRODUCTION: There is great prevalence of extra-intestinal manifestations (EIM in Crohn's disease(CD and ulcerative rectocolitis (UR, varying from 24 to 65%. AIM: To determine the prevalence of EIM in UR and CD, establishing a correlation with the diagnosis of the kind of intestinal inflammatory disease, extension, evolution time and disease activity. METHODS: One thousand patients were evaluated at the Hospital das Clínicas da FMUSP, along the 1984 to 2004 period. Articular, dermatological, ophthalmologic, urologic, hepatic, pulmonary and vascular manifestations were studied. RESULTS: 468

Studies on mutagen-sensitive strains of Drosophila melanogaster. IV

International Nuclear Information System (INIS)

Ferro, W.

1985-01-01

The influence of defects in DNA repair processes on X-ray-induced genetic damage in post-meiotic male germ cell stages of Drosophila melanogaster was studied using the 'maternal effects approach'. Basc males were irradiated in N 2 , air or O 2 either as 48-h-old pupae (to sample spermatids) or as 3-4-day-old adults (to sample mature spermatozoa) and mated to females of 3 repair-deficient strains. Simultaneous controls involving mating of males to repair-proficient females (mei + ) were run. The frequencies of sex-linked recessive lethals and of autosomal translocations were determined following standard genetic procedures. The responses elicited in the different crosses with repair-deficient females were compared with those in mei + crosses. (Auth.)

Integrated Microchannel Reformer/Hydrogen Purifier for Fuel Cell Power Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Makel Engineering, Inc. (MEI) and Colorado School of Mines (CSM) propose to develop an integrated hydrogen generator and purifier system for conversion of in-situ...

De kloof tussen wetenschap en praktijk dichten Carel hulshof

NARCIS (Netherlands)

Putten, D. van

2011-01-01

Carel Hulshof is per 1 mei 2011 benoemd tot bijzonder hoogleraar Arbeids- en Bedrijfsgeneeskunde aan de Universiteit van Amsterdam bij het Coronel Instituut voor Arbeid en Gezondheid van het Academisch Medisch Centrum.

El Derecho a la Salud en Latinoamérica y la Unión Europea. Accesibilidad en contextos de crisis

OpenAIRE

Quercetti, Florencia

2014-01-01

Treballs finals del Màster "Estudios Internacionales: organizaciones internacionales y cooperación – Colección Memorias MEI", Facultat de Dret, Universitat de Barcelona, Curs:2013-2014 , Directora: Marta Ortega Gomez

Niagaara meis ja meie Niagaara kohal / Tõnis Tõnisson

Index Scriptorium Estoniae

Tõnisson, Tõnis, 1945-

2006-01-01

Alonso Alegria näidend "Niagaara" Juuru lähistel Atla mõisas, lavastaja Jaan Urvet. Lisatud Jean Francois Gravelet' ja Alonso Alegria lühitutvustus, allikas "kavaleht". Ajalehe rubriik Eesti teatri aasta 2006 : Teatriküljed, 9

[Help me--I do not tolerate my statin].

Science.gov (United States)

Nater, Harald; Perger, Ludwig; Suter, Paolo M

2015-05-06

Statins represent the most widely prescribed drugs. Accordingly, in daily practice statin-related muscle pain and other myopathic sensations are frequently seen. In this practice review the clinical approach to statin myopathy is discussed.

Biezeno en de mechanica - Herdenkingsdag 14 mei 1976.

NARCIS (Netherlands)

Biezeno, C.B.; Geerlings, J.J.P.; Haringx, J.A.; Meijers, P.; Van der Neut, A.

1976-01-01

Presentations at a symposium commemorating the death of prof.dr.ir. C.B. Biezeno on 5 September 1975. Presentations by prof. A. van der Neut, prof. R.G. Boiten, prof. W.T. Koiter, prof. J.P. den Hartog, and prof. J.F. Besseling.

Saared meis ja meie ümber / Katrin Nielsen

Index Scriptorium Estoniae

Nielsen, Katrin

1998-01-01

Chaplini kunstikeskuses 17. detsembrini avatud fotonäitusest 'Põhjala saared', kus oma töid eksponeerisid: Absalon Hansen - Fääri saartest, Göte Ask - Gotlandist, Andy Horner - Ahvenamaalt, ning Tartu kunstikooli fotoeriala tudengid oma pilte Naissaarest, Piirissaarest, Abrukast, Manijast, Vormsist ja Vilsandist.

CILJANI KUPAC KAO GLAVNA KARIKA USPJEHA

OpenAIRE

Primorac, Maristela

2016-01-01

Naš poslovni uspjeh ovisi o našim potrošačima! Kupac, odnosno potrošač, aktivno traži dobavljača koji može zadovoljiti njegove potrebe. Na taj se način stvara lojalni kupac koji postiže stalnu i ponovnu kupnju. Treba imati na umu kako se zahtjevi kupaca povećavaju paralelno s rastom mogućnosti tehnologije, a svijest o kupcu kao najvažnijoj karici u lancu treba trajno održavati na najvišoj razini. Razvijanjem strategije brige za kupce gospodarski se subjekt modernizira i tržišno usmjerava. Pos...

Etika u poduzetništvu

OpenAIRE

Ivančir, Monika

2018-01-01

Ovim diplomskim radom ukazuje se na problematiku današnjice glede poslovne etike. Naglasak se stavlja na etiku u poduzetništvu. Istaknuti su najčešći moralni problemi s kojima se susreću današnji poduzetnici i želi se naglasiti važnost etike u svim poslovnim odnosima i odlukama. Zadaća svakog poduzetnika, koji se želi voditi načelima etike, jest da uspostavi ravnotežu između ekonomske i društveno odgovorne strane poslovanja. Samo na taj način, na današnjem promjenjivom tržištu, poduzetnik...

MARKETING INFORMACIJA

OpenAIRE

Mecanović, Ivan

1991-01-01

Informacija se sve više pojavljuje kao roba na tržištu. Bez obzira ima li ona status medijske vijesti, ili informacije, koja se dobiva iz informatičkog sistema, informacija se proizvodi; sortira, čuva i lansira, te na taj način postaje proizvod, koji ima svoju cijenu koštanja, kao i svoju prodajnu cijenu, svoje potrošače i svoje tržište. Zbog toga je potrebno stvarati i marketing informacija. No, informacija je specifična roba osobne potrošnje. Korištenjem, ili spoznajnošču informacije od poj...

Brightness enhancement of plasma ion source by utilizing anode spot for nano applications

Energy Technology Data Exchange (ETDEWEB)

Park, Yeong-Shin; Lee, Yuna; Chung, Kyoung-Jae; Hwang, Y. S. [Department of Nuclear Engineering, Seoul National University, Seoul 151-742 (Korea, Republic of); Kim, Yoon-Jae [Samsung Electronics Co. Ltd., Gyeonggi 445-701 (Korea, Republic of); Park, Man-Jin [Research Institute of Nano Manufacturing System, Seoul National University of Science and Technology, Seoul 139-743 (Korea, Republic of); Moon, Dae Won [Nanobio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon 305-600 (Korea, Republic of)

2012-02-15

Anode spots are known as additional discharges on positively biased electrode immersed in plasmas. The anode spot plasma ion source (ASPIS) has been investigated as a high brightness ion source for nano applications such as focused ion beam (FIB) and nano medium energy ion scattering (nano-MEIS). The generation of anode spot is found to enhance brightness of ion beam since the anode spot increases plasma density near the extraction aperture. Brightness of the ASPIS has been estimated from measurement of emittance for total ion beam extracted through sub-mm aperture. The ASPIS is installed to the FIB system. Currents and diameters of the focused beams with/without anode spot are measured and compared. As the anode spot is turned on, the enhancement of beam current is observed at fixed diameter of the focused ion beam. Consequently, the brightness of the focused ion beam is enhanced as well. For argon ion beam, the maximum normalized brightness of 12 300 A/m{sup 2} SrV is acquired. The ASPIS is applied to nano-MEIS as well. The ASPIS is found to increase the beam current density and the power efficiency of the ion source for nano-MEIS. From the present study, it is shown that the ASPIS can enhance the performance of devices for nano applications.

Pacific Northwest National Laboratory Site Radionuclide Air Emissions Report for Calendar Year 2012

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F.; Barnett, J. Matthew; Bisping, Lynn E.

2013-06-06

This report documents radionuclide air emissions that result in the highest effective dose equivalent (EDE) to a member of the public, referred to as the maximally exposed individual (MEI). The report has been prepared in compliance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (NESHAP), Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities and Washington Administrative Code (WAC) Chapter 246-247, Radiation Protection Air Emissions. The dose to the PNNL Site MEI due to routine major and minor point source emissions in 2012 from PNNL Site sources is 9E-06 mrem (9E-08 mSv) EDE. The dose from fugitive emissions (i.e., unmonitored sources) is 1E-7 mrem (1E-9 mSv) EDE. The dose from radon emissions is 2E-6 mrem (2E-08 mSv) EDE. No nonroutine emissions occurred in 2012. The total radiological dose for 2012 to the MEI from all PNNL Site radionuclide emissions, including fugitive emissions and radon, is 1E-5 mrem (1E-7 mSv) EDE, or 100,000 times smaller than the federal and state standard of 10 mrem/yr, to which the PNNL Site is in compliance.

Pacific Northwest National Laboratory Campus Radionuclide Air Emissions Report for Calendar Year 2013

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F.; Barnett, J. Matthew; Bisping, Lynn E.

2014-06-01

This report documents radionuclide air emissions that result in the highest effective dose equivalent (EDE) to a member of the public, referred to as the maximally exposed individual (MEI). The report has been prepared in compliance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (NESHAP), Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities and Washington Administrative Code (WAC) Chapter 246-247, Radiation Protection Air Emissions. The dose to the PNNL Site MEI due to routine major and minor point source emissions in 2013 from PNNL Site sources is 2E-05 mrem (2E-07 mSv) EDE. The dose from fugitive emissions (i.e., unmonitored sources) is 2E-6 mrem (2E-8 mSv) EDE. The dose from radon emissions is 1E-11 mrem (1E-13 mSv) EDE. No nonroutine emissions occurred in 2013. The total radiological dose for 2013 to the MEI from all PNNL Site radionuclide emissions, including fugitive emissions and radon, is 2E-5 mrem (2E-7 mSv) EDE, or 100,000 times smaller than the federal and state standard of 10 mrem/yr, to which the PNNL Site is in compliance

Pacific Northwest National Laboratory Campus Radionuclide Air Emissions Report for Calendar Year 2014

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Barnett, J. Matthew [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bisping, Lynn E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2015-06-01

This report documents radionuclide air emissions that result in the 2014 highest effective dose equivalent (EDE) to an offsite member of the public, referred to as the maximally exposed individual (MEI). The report has been prepared in compliance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (NESHAP), Subpart H, “National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities” and Washington Administrative Code (WAC) Chapter 246-247, “Radiation Protection–Air Emissions.” The dose to the PNNL Campus MEI due to routine major and minor point source emissions in 2014 from PNNL Campus sources is 2E 05 mrem (2E-07 mSv) EDE. The dose from all fugitive sources is 3E-6 mrem (3E-8 mSv) EDE. The dose from radon emissions is 1E-6 mrem (1E-8 mSv) EDE. No nonroutine emissions occurred in 2014. The total radiological dose for 2014 to the MEI from all PNNL Campus radionuclide emissions, including fugitive emissions and radon, is 3E-5 mrem (3E-7 mSv) EDE, or more than 100,000 times smaller than the federal and state standard of 10 mrem/yr, to which the PNNL Campus is in compliance.

Pacific Northwest National Laboratory Campus Radionuclide Air Emissions Report for Calendar Year 2015

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Barnett, J. Matthew [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bisping, Lynn E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2016-06-01

This report documents radionuclide air emissions that result in the 2015 highest effective dose equivalent (EDE) to an offsite member of the public, referred to as the maximally exposed individual (MEI). The report has been prepared in compliance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (NESHAP), Subpart H, “National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities” and Washington Administrative Code (WAC) Chapter 246-247, “Radiation Protection–Air Emissions.” The dose to the PNNL Campus MEI from routine major and minor point source emissions in 2015 from PNNL Campus sources is 2.6E-4 mrem (2.6E-6 mSv) EDE. The dose from all fugitive sources is 1.8E-6 mrem (1.8E-8 mSv) EDE. The dose from radon emissions is 4.4E-8 mrem (4.4E-10 mSv) EDE. No nonroutine emissions occurred in 2015. The total radiological dose to the MEI from all PNNL Campus radionuclide emissions, including fugitive emissions and radon, is 2.6E-4 mrem (2.6E-6 mSv) EDE, or more than 10,000 times less than the federal and state standard of 10 mrem/yr, with which the PNNL Campus is in compliance.

Estándares internacionales del trabajo infantil: el caso de Costa Rica

OpenAIRE

Salvador Ferrer, Ángel

2015-01-01

Treballs finals del Màster "Estudios Internacionales: organizaciones internacionales y cooperación – Colección Memorias MEI", Facultat de Dret, Universitat de Barcelona, Curs:2013-2014 , Tutor: Jordi Bonet Pérez

Violencia extrema contra las mujeres. Feminicidios, violencia física y violencia sexual. Estudio comparativo en cuatro países

OpenAIRE

Pastor Pastor, Maria Mercè

2017-01-01

Treballs finals del Màster "Estudios Internacionales: organizaciones internacionales y cooperación – Colección Memorias MEI", Facultat de Dret, Universitat de Barcelona, Curs:2016-2017. Tutora: Marta Ortega Gómez

Business Model Canvas

NARCIS (Netherlands)

D'Souza, Austin

2013-01-01

Presentatie gegeven op 13 mei 2013 op de bijeenkomst "Business Model Canvas Challenge Assen".
Het Business Model Canvas is ontworpen door Alex Osterwalder. Het model werkt zeer overzichtelijk en bestaat uit negen bouwstenen.

La seguridad alimentaria en el África Subsahariana y la cooperación Sur-Sur brasileña en materia agrícola: potencialidades y límites

OpenAIRE

De Andrade e Sousa, Maria Eduarda

2014-01-01

Treballs finals del Màster "Estudios Internacionales: organizaciones internacionales y cooperación – Colección Memorias MEI", Facultat de Dret, Universitat de Barcelona, Curs:2013-2014 , Director: Xavier Fernández Pons

Uudised : Andresepäev eesti muusikaga. Esitleti Piazzolla plaati. Eesti luule esimene CD / Raili Sule

Index Scriptorium Estoniae

Sule, Raili, 1944-

2000-01-01

A. Marguste autorikontserdist sarjas "Eesti heliloojad talveaias" 30. nov. Argentiina restoranis esitleti CD-plaati "Tango King Astor Piazzolla". 9. dets. esitleti rahvusraamatukogus uut CD-plaati eesti luulest ja muusikast "Maa meis ja maa maailmas"

A MODIFIED CUMULUS PARAMETERIZATION SCHEME AND ITS APPLICATION IN THE SIMULATIONS OF THE HEAVY PRECIPITATION CASES

Institute of Scientific and Technical Information of China (English)

PING Fan; TANG Xi-ba; YIN Lei

2016-01-01

According to the characteristics of organized cumulus convective precipitation in China,a cumulus parameterization scheme suitable for describing the organized convective precipitation in East Asia is presented and modified.The Kain-Fristch scheme is chosen as the scheme to be modified based on analyses and comparisons of simulated precipitation in East Asia by several commonly-used mesoscale parameterization schemes.A key dynamic parameter to dynamically control the cumulus parameterization is then proposed to improve the Kain-Fristch scheme.Numerical simulations of a typhoon case and a Mei-yu front rainfall case are carried out with the improved scheme,and the results show that the improved version performs better than the original in simulating the track and intensity of the typhoons,as well as the distribution of Mei-yu front precipitation.

ANALISIS POLA MUSIM TANAM RUMPUT LAUT, Kappaphycus alvarezii MELALUI PENDEKATAN KESESUAIAN LAHAN DI NUSA PENIDA, BALI

Directory of Open Access Journals (Sweden)

I Nyoman Radiarta

2014-08-01

Full Text Available Usaha budidaya rumput laut sangat dipengaruhi oleh lokasi dan iklim. Penyusunan pola musim tanam rumput laut yang benar dapat membantu dalam keberlanjutan usaha budidaya. Tujuan penelitian ini adalah untuk menganalisis pola musim tanam rumput laut, Kappaphycus alvarezii, berdasarkan pendekatan kesesuaian lahan pengembangan budidaya rumput laut di Nusa Penida, Bali. Data dikumpulkan pada bulan Mei dan September 2013. Kesesuaian lahan dianalisis secara spasial berdasarkan sistem informasi geografis, dengan memadukan antara faktor kualitas perairan dan sosialinfrastruktur. Hasil analisis menunjukkan bahwa bulan Mei merupakan bulan yang sesuai untuk K. alvarezii dibandingkan dengan bulan September. Kawasan Pulau Nusa Lembongan dan Nusa Ceningan merupakan kawasan yang lebih sensitif terhadap perubahan kondisi perairan. Hasil penelitian ini dapat dijadikan acuan dalam penyusunan strategi musim tanam di Nusa Penida.

Impactos do simples na sociedade: uma análise da arrecadação e dos empregos gerados pelas microempresas, empresas de pequeno porte e pelos microempreendedores individuais = Impacts of the 'simple tax' in society: an analysis of revenue and jobs generated by the micro, small businesses and individuals by micro entrepreneurs

Directory of Open Access Journals (Sweden)

Marcelo Driemeyer Wilbert

2015-08-01

Full Text Available Em 1996 a carga tributária das Microempresas (ME e Empresas de Pequeno Porte (EPP foi reduzida por meio da criação do Sistema Integrado de Pagamento de Impostos e Contribuições das Microempresas e das Empresas de Pequeno Porte (SIMPLES, que é um regime especial unificado de arrecadação de tributos e contribuições. Essa redução da carga tributária representa uma importante renúncia de receita ao Estado, o que representa um custo para o país e justifica a importância do seu estudo. Assim, o objetivo do presente artigo é fazer uma análise da arrecadação do SIMPLES e do SIMPLES Nacional e da geração de empregos pelas ME, EPP e pelos Microempreendedores Individuais (MEI, para verificar benefícios à sociedade. Como instrumento de pesquisa, utilizou-se revisão bibliográfica, coleta de dados para o período de 2002 a 2013 e análise desses dados por meio de estatística descritiva. Foi verificado que a arrecadação tributária pelo SIMPLES apresentou um crescimento mais de três vezes superior ao crescimento da arrecadação dos outros regimes, no período de 2007 a 2013. Além disso, observa-se que apesar das ME, EPP e MEI possuírem participação expressiva no número de empregos, essa participação reduziu no período estudado. Constatou-se que a partir de 2009, com a influência dos MEI, a arrecadação média por empresa no SIMPLES tem apresentado diminuição.In 1996, Microenterprises' (ME and Small Enterprises' (EPP tax burden was reduced by the creation of the Integrated System for Payment of Taxes and Contributions of Micro and Small Enterprises (SIMPLES, which is a special unified regime applied to collect federal taxes and contributions of such companies. This tax reduction is an important waiver of revenue to the state, which represents a cost to the country and justifies the importance of this study. The objective of this paper is to analyze the collection of 'SIMPLES' tax and the consequent generation of jobs

Climatic Variations in Tropical West African Rainfall and the Implications for Military Planners

National Research Council Canada - National Science Library

Montgomery, Christi S

2008-01-01

...) and El Nino/La Nina (ENLN) events in the tropical Pacific. Our primary data sets were the National Centers for Environmental Prediction / National Center for Atmospheric Research reanalysis fields and the Multivariate ENSO Index (MEI...

Agter elke man: Onderweg na inklusiewe taalgebruik in die ...

African Journals Online (AJOL)

31 Mei 2016 ... Agter elke man: Onderweg na inklusiewe taalgebruik in die Afrikaanse kerklied .... reaksie van gemeentelede en opmerkings op sosiale media ..... and unstable masculinity/ies of Jesus Christ and the multiple and changing ...

La calificación del secuestro de menores durante el Franquismo como crimen contra la humanidad y la lucha contra su impunidad en el Estado Español

OpenAIRE

Millaret Lores, Eulàlia

2013-01-01

Treballs finals del Màster "Estudios Internacionales: organizaciones internacionales y cooperación – Colección Memorias MEI", Facultat de Dret, Universitat de Barcelona, Curs:2012-2013 , Directora: Rosa Ana Alija Fernández

Pühaderoad terviseks / Eva Mere

Index Scriptorium Estoniae

Mere, Eva

1999-01-01

Kuidas peavad jõulupühi need, kes teistele söögitegemist õpetavad. Ajakirjade köögitoimetajad : Maire Suitsu Eesti Naisest, Kaie Mei Stiilist ja Tervisest, Angeelika Kang Kodukirjast, Lia Virkus Perest ja Kodust

Editorial/Van die Redaksie

African Journals Online (AJOL)

4 Mei 1991 ... sphincter dysfunction and mild or insignificant sensory disturbance. Upper limb ... a panel of monoclonal antibodies, or viral nucleic acids using in situ .... lished their own training programmes and specialties. In 1990 the South ...

First collaborative study on bacteriophages in bathing waters

NARCIS (Netherlands)

Mooijman KA; Ghameshlou Z; Bahar M; Havelaar AH; MGB

1998-01-01

Het eerste internationale ringonderzoek met bacteriofagen in zwemwater werd in mei 1997 georganiseerd. Zestien Europese laboratoria (inclusief het organiserende laboratorium) namen deel aan de studie. Zij analyseerden faag referentiematerialen (RMs) voor de bepaling van somatische colifagen (RMs

Environmental influences on the abundance and sexual composition of white sharks Carcharodon carcharias in Gansbaai, South Africa.

Science.gov (United States)

Towner, Alison V; Underhill, Les G; Jewell, Oliver J D; Smale, Malcolm J

2013-01-01

The seasonal occurrence of white sharks visiting Gansbaai, South Africa was investigated from 2007 to 2011 using sightings from white shark cage diving boats. Generalized linear models were used to investigate the number of great white sharks sighted per trip in relation to sex, month, sea surface temperature and Multivariate El Niño/Southern Oscillation (ENSO) Indices (MEI). Water conditions are more variable in summer than winter due to wind-driven cold water upwelling and thermocline displacement, culminating in colder water temperatures, and shark sightings of both sexes were higher during the autumn and winter months (March-August). MEI, an index to quantify the strength of Southern Oscillation, differed in its effect on the recorded numbers of male and female white sharks, with highly significant interannual trends. This data suggests that water temperature and climatic phenomena influence the abundance of white sharks at this coastal site. In this study, more females were seen in Gansbaai overall in warmer water/positive MEI years. Conversely, the opposite trend was observed for males. In cool water years (2010 to 2011) sightings of male sharks were significantly higher than in previous years. The influence of environmental factors on the physiology of sharks in terms of their size and sex is discussed. The findings of this study could contribute to bather safety programmes because the incorporation of environmental parameters into predictive models may help identify times and localities of higher risk to bathers and help mitigate human-white shark interactions.

Spatial and temporal variability of the Choco jet stream and its effect on the hydroclimatology of the Colombian pacific

International Nuclear Information System (INIS)

Rueda, Oscar A; Poveda, German

2006-01-01

The Chorro del occidente Colombiano Choco is a low level jet that determines the hydroclimatology of the Colombian pacific region. In this paper, the spatial and temporal variability of the Choco were analyzed. To study this variability, the southern oscillation index (SOI) and multivariate ENSO index (MEI) from the national center for environmental prediction/national center for atmospheric research (NCEP/NCAR) were used. Sea surface temperatures (SST), specific humidity (Shum), and wind speed (WS) data were also utilized. The annual advection cycle of humidity in the core of the Choco was investigated at three different longitudes. A correlation was established between this advection cycle and the temperature gradient involving two zones of the western tropical pacific. These zones are El Nino 1+2 and the Colombian Pacific Ocean. The interannual variability of the Choco associated with both El Nino and La Nina phases of ENSO were derived from a correlation coefficient between the jet's core and both the SOI and the MEI. A wavelet analysis was made between the advection cycle and both the precipitation and river flow in the Colombian pacific region was also studied. The most important outcome of this research is a linkage relating the SST, SOI and MEI with the advection of the Choco, indicating a significant coupling of these variables and both the annual and interannual variability of the jet. These results reveal that the hydroclimatology of the Colombian pacific region is related to the amount of moisture carried by the Choco

Limnological evaluation of the fisheries potentials and productivity of a small shallow tropical African reservoir.

Science.gov (United States)

Mustapha, Moshood K

2009-12-01

Morphometrics and physico-chemical parameters of Oyun reservoir, Offa, Nigeria (a small shallow tropical African Reservoir) were used to estimate the potential fish yield of the reservoir according to the morpho-edaphic index (MEI). Physico-chemical characteristics of the water body were sampled monthly from three stations between January 2002 and December 2003 with standard methods. Estimates of the potential fish yield were obtained using the physico-chemical characteristics of the reservoir and the relationship Y = 23.281 MEI(0.447), where Y is the potential fish yield in kg/ha, MEI is the morpho-edaphic index (given in microS/cm and estimated by dividing the mean conductivity by the mean depth). The reservoir mean depth and conductivity values were 2.6m and 113.10 microS/cm respectively, while its potential fish yield was estimated at 125.72 kg/ha. This estimate was higher than other small shallower and larger African reservoirs. The reservoir high ionic content, high nutrient and dissolved oxygen levels, good pH, low level of pollution and shallow depth were responsible for the high estimate of the fish yield. In order to realize this high potential fish yield and sustainable exploration of the fisheries, effective management of the reservoir to curb eutrophication should be adopted, while other management practices such as stocking and conservation of desirable and indigenous fish species, implementation of fishing regulations and adoption of best management practices should be implemented.

Genetic parameters and estimated genetic gains in young rubber tree progenies

Directory of Open Access Journals (Sweden)

Cecília Khusala Verardi

2013-04-01

Full Text Available The objective of this work was to assess the genetic parameters and to estimate genetic gains in young rubber tree progenies. The experiments were carried out during three years, in a randomized block design, with six replicates and ten plants per plot, in three representative Hevea crop regions of the state of São Paulo, Brazil. Twenty-two progenies were evaluated, from three to five years old, for rubber yield and annual girth growth. Genetic gain was estimated with the multi-effect index (MEI. Selection by progenies means provided greater estimated genetic gain than selection based on individuals, since heritability values of progeny means were greater than the ones of individual heritability, for both evaluated variables, in all the assessment years. The selection of the three best progenies for rubber yield provided a selection gain of 1.28 g per plant. The genetic gains estimated with MEI using data from early assessments (from 3 to 5-year-old were generally high for annual girth growth and rubber yield. The high genetic gains for annual girth growth in the first year of assessment indicate that progenies can be selected at the beginning of the breeding program. Population effective size was consistent with the three progenies selected, showing that they were not related and that the population genetic variability is ensured. Early selection with the genetic gains estimated by MEI can be made on rubber tree progenies.

EMP Attachment 3 DOE-SC PNNL Site Dose Assessment Guidance

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F.

2011-12-21

This Dose Assessment Guidance (DAG) describes methods to use to determine the Maximally-Exposed Individual (MEI) location and to estimate dose impact to that individual under the U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Site Environmental Monitoring Plan (EMP). This guidance applies to public dose from radioactive material releases to the air from PNNL Site operations. This document is an attachment to the Pacific Northwest National Laboratory (PNNL) Environmental Monitoring Plan (EMP) and describes dose assessment guidance for radiological air emissions. The impact of radiological air emissions from the U.S. Department of Energy Office of Science (DOE-SC) PNNL Site is indicated by dose estimates to a maximally exposed member of the public, referred to as the maximally exposed individual (MEI). Reporting requirements associated with dose to members of the public from radiological air emissions are in 40 CFR Part 61.94, WAC 246-247-080, and DOE Order 458.1. The DOE Order and state standards for dose from radioactive air emissions are consistent with U.S. Environmental Protection Agency (EPA) dose standards in 40 CFR 61.92 (i.e., 10 mrem/yr to a MEI). Despite the fact that the current Contract Requirements Document (CRD) for the DOE-SC PNNL Site operations does not include the requirement to meet DOE CRD 458.1, paragraph 2.b, public dose limits, the DOE dose limits would be met when EPA limits are met.

An Internet of Things System for Underground Mine Air Quality Pollutant Prediction Based on Azure Machine Learning.

Science.gov (United States)

Jo, ByungWan; Khan, Rana Muhammad Asad

2018-03-21

The implementation of wireless sensor networks (WSNs) for monitoring the complex, dynamic, and harsh environment of underground coal mines (UCMs) is sought around the world to enhance safety. However, previously developed smart systems are limited to monitoring or, in a few cases, can report events. Therefore, this study introduces a reliable, efficient, and cost-effective internet of things (IoT) system for air quality monitoring with newly added features of assessment and pollutant prediction. This system is comprised of sensor modules, communication protocols, and a base station, running Azure Machine Learning (AML) Studio over it. Arduino-based sensor modules with eight different parameters were installed at separate locations of an operational UCM. Based on the sensed data, the proposed system assesses mine air quality in terms of the mine environment index (MEI). Principal component analysis (PCA) identified CH₄, CO, SO₂, and H₂S as the most influencing gases significantly affecting mine air quality. The results of PCA were fed into the ANN model in AML studio, which enabled the prediction of MEI. An optimum number of neurons were determined for both actual input and PCA-based input parameters. The results showed a better performance of the PCA-based ANN for MEI prediction, with R ² and RMSE values of 0.6654 and 0.2104, respectively. Therefore, the proposed Arduino and AML-based system enhances mine environmental safety by quickly assessing and predicting mine air quality.

An Internet of Things System for Underground Mine Air Quality Pollutant Prediction Based on Azure Machine Learning

Directory of Open Access Journals (Sweden)

ByungWan Jo

2018-03-01

Full Text Available The implementation of wireless sensor networks (WSNs for monitoring the complex, dynamic, and harsh environment of underground coal mines (UCMs is sought around the world to enhance safety. However, previously developed smart systems are limited to monitoring or, in a few cases, can report events. Therefore, this study introduces a reliable, efficient, and cost-effective internet of things (IoT system for air quality monitoring with newly added features of assessment and pollutant prediction. This system is comprised of sensor modules, communication protocols, and a base station, running Azure Machine Learning (AML Studio over it. Arduino-based sensor modules with eight different parameters were installed at separate locations of an operational UCM. Based on the sensed data, the proposed system assesses mine air quality in terms of the mine environment index (MEI. Principal component analysis (PCA identified CH4, CO, SO2, and H2S as the most influencing gases significantly affecting mine air quality. The results of PCA were fed into the ANN model in AML studio, which enabled the prediction of MEI. An optimum number of neurons were determined for both actual input and PCA-based input parameters. The results showed a better performance of the PCA-based ANN for MEI prediction, with R2 and RMSE values of 0.6654 and 0.2104, respectively. Therefore, the proposed Arduino and AML-based system enhances mine environmental safety by quickly assessing and predicting mine air quality.

Pólen 2n e mecanismos meióticos de formação em Solanum commersonii ssp 2n pollen and meiotic mechanisms of Formation in Solanum commersonii ssp

Directory of Open Access Journals (Sweden)

Lívia Gracielle Oliveira Tomé

2009-04-01

Full Text Available Solanum commersonii subsp. commersonii Dun. e Solanum commersonii subsp. malmeanum Bitt. (2n=2x=24 - 1EBN não podem ser diretamente cruzadas com a batata cultivada de S. tuberosum subsp. tuberosum L. (2n=4x=48 -4 EBN em razão da barreira da ploidia e do número de equilíbrio do endosperma (EBN. No entanto, a produção de pólen não reduzido por S. commersonii ssp. (2x=2n=24 - 1EBN, permite o cruzamento desta com dihaplóides de batata e com as espécies diplóides S. phureja Juz. & Bukasov. e S. chacoense Bitt., que possuem 2 EBN. Conduziu-se este trabalho, com o objetivo de determinar o mecanismo meiótico e a freqüência dos grãos de pólen não reduzidos em cinco clones de Solanum commersonii ssp. Foram avaliados três clones de S. commersonii subsp. commersonii (SCC e dois de S. commersonii subsp. malmeanum (SCM. Nas avaliações, duzentos grãos de pólen viáveis foram corados (carmim acético 2% e mensurados, sendo considerados não reduzidos aqueles com o diâmetro igual ou superior a 25 µm. O clone Solanum commersonii subsp. commersonii Dun. (SCC 100 produz 26.1% de polen não reduzido, por fusos fundidos e fusos paralelos, o qual pode ser utilizado em programas de melhoramento.Solanum commersonii subsp. commersonii Dun. and Solanum commersonii subsp. malmeanum Bitt. (2n=2x=24 -1EBN cannot be directly crossed with the cultivated Solanum tuberosum subsp. Tuberosum L. (2n=4x=48 - 4EBN species due to ploidy barriers and endosperm balance number (EBN. However, non-reduced pollen production by the wild species S. commersonii ssp. (2x=2n=24 -1EBN, allows the crossing of these species with dihaploids of potato and with the diploids species, S. phureja Juz. & Bukasov. and S. chacoense Bitt., all with 2EBN. The aim of this work was to determine the meiotic mechanism and frequency of non-reduced pollen production of five clones of S. commersonii ssp. Three different clones of S. commersonii subsp. commersonii Dun. (SCC and two of S

Pantex Plant Cell 12-44-1 tritium release: Re-assessment of environmental doses for 1990 to 1992

International Nuclear Information System (INIS)

Snyder, S.F.; Hwang, S.T.

1994-03-01

A release of tritium gas occurred within Cell 12-44-1 at the Pantex Plant on May 17, 1989. The release was the result of a nuclear component containment failure. This document summarizes past assessments and characterization of the release. From 1990 to 1992, the average annual dose to the offsite maximally exposed individual (MEI), re-assessed using updated methods and data, ranged from 9E-6 to 2E-4 mrem/y. Doses at this level are well below the regulatory dose limit and support the discontinuation of the distinct calculation of the MEI doses from the cell's tritium releases in future Pantex Annual Site Environmental Reports. Additional information provides guidance for the evaluation of similar releases in the future. Improved Environmental Protection Department sampling plans and assessment goals will increase the value of the data collected during future incidents

Tartu koolkond ajakirjade kujundajana 1930-1940 / Merle Talvik

Index Scriptorium Estoniae

Talvik, Merle, 1971-

2006-01-01

Õppesüsteemist ja graafika õpetamisest Pallase Kõrgemas Kunstikoolis. Tartu kunstnikud ajakirjade kujundajana: Nikolai Triik, Ernst Kollom, Arkadio Laigu, Natalie Mei, Ado Vabbe, Ott Kangilaski, Hando Mugasto, Eduard Wiiralt, Peet Aren, Jaan Vahtra, Rudolf Paris, Agu Peerna jt

Bestrijdingsmiddelen in oppervlaktewater uit het bollengebied bij 't Langeveld

NARCIS (Netherlands)

Greve PA; Klapwijk SP; Linders JBHJ

1989-01-01

Op vijf locaties in het gebied "'t Langeveld" van de naast de Amsterdamse en Noordwijkse waterleidingduinen gelegen Noordzijderpolder zijn gedurende de maanden mei 1987 t/m januari 1988 maandelijks monsters oppervlaktewater genomen en onderzocht op 39 bestrijdingsmiddelen en

The eleventh CRL-Salmonella workshop, 9 May 2006, Saint Malo, France

NARCIS (Netherlands)

Mooijman KA; MGB

2006-01-01

De elfde workshop georganiseerd door het Communautair Referentie Laboratorium voor Salmonella (CRL-Salmonella) werd gehouden op 9 mei 2006 in Saint Malo, Frankrijk. Deelnemers waren vertegenwoordigers van de nationale Referentie Laboratoria voor Salmonella (NRLs-Salmonella) van de lidstaten van de

ZELFVOORZIENEND ZERNIKE

NARCIS (Netherlands)

Falkena, Henk-Jan

2011-01-01

Versie Definitieve rapportage - 30 mei 2011 Opdrachtgever Stuurgroep Duurzaamheid van de Rijksuniversiteit Groningen Adviescommissie RUG prof dr. H.C. Moll (voorzitter en contactpersoon) prof. dr. S. Brandenburg (hoofd accelerator group van het KVI) prof. dr. J.C. Hummelen (hoogleraar organische

Uitdagend en waardevol

NARCIS (Netherlands)

Van Hal, J.D.M.

2008-01-01

Uitdagend en waardevol Intreerede Uitgesproken op 7 mei 2008 ter gelegenheid van de aanvaarding van het ambt van hoogleraar Sustainable Housing Transformation aan de Faculteit Bouwkunde van de Technische Universiteit Delft door Prof. Dr. Ir. J.D.M. van Hal.

Jonkheer Drs. Willem Cornelis van Heurn (1887-1972)

NARCIS (Netherlands)

Holthuis, L.B.; Husson, A.M.

1973-01-01

INHOUD Ι. Inleiding .................. 3 2. Nederland (1887-1911)............... 4 3. Verzameltocht naar Suriname (12 mei-10 november 1911)..... 6 4. Nederland (1911-1912)............... 11 5. Reis naar Simaloer en West-Sumatra (1912-1914)........ 12 6. Nederland (1914-1918)............... 17 7.

CONE BIOPSY IN PREGNANCY*

African Journals Online (AJOL)

1 Mei 1971. S.-A. TYDSKRIF VIR OBSTETRIE EN GINEKOLOGIE. CONE BIOPSY ... of the abnormal cervix in pregnancy is also no longer in question following the .... the concept of cancer prophylaxis to the majority of women, many of whom ...

BKR 27(2) pp. 63-67 (Ejike et al)

African Journals Online (AJOL)

Femi J. Olorunniji

2015-06-30

Jun 30, 2015 ... (Ejike and Ezeanyika, 2008; Bastien et al., 2014). The body mass index (BMI) is the .... Mei Z, Grummer-Strawm LM, Pietrobelli A, Goulding A,. Goran MI, Dietz WH. ... Nutrition Examination Survey (1988-1994). Am J Clin Nutr;.

Handboek Communicatie

NARCIS (Netherlands)

drs. Wil Michels

2010-01-01

Internet heeft een enorme impact op de manier hoe we communiceren. Arbeidsmarktcommunicatie, crisiscommunicatie, social media communicatietheorie, alles verandert. Gedurende 2 jaar is het Handboek Communicatie herschreven en de nieuwe versie die in mei 2010 is uitgekomen, is weer actueel en besteedt

Tuvan music and World Music

Directory of Open Access Journals (Sweden)

Maxim V. Chaposhnikov

2017-06-01

Full Text Available The essay presents the author’s observations about the ingression of Tuvan music into the World Music – a niche of world musical culture covering ethnical music traditions. The author has witnessed the rise of interest to traditional musical culture of Tuva and Russia as well as globalization of Tuvan music. He is endeavoring to interpret these changes and reveal their affect on traditional music and xöömei. In the late Soviet period, traditional music in Tuva, like in many republics of the Union, has been as if put on hold. During the Perestroika and national revival processes, traditionalism became of high demand. Symposia and festivals started off in Tuva where amateur participants took the same stage with professionals. Special honor was paid to old masters of xöömei. Scholars started engaging in  discussions about the origins and a role of xöömei and its genres. Хöömei attracted a good deal of market interest from outside Russia. In the late 1980s American scientist and producer T. Levin made first field records of xöömei to be released on a disk. Ethnographic ensemble “Tuva” was established. Later, members of “Tuva” started their own musical bands. Musical programs were compiled as an ethnographic variety show – a principle that the public has been seeking for both in Tuva and abroad. Disks were realeased and artists started active touring in foreign countries. Boosting interest in World Music was marked with hallmark attention to the phenomenon of throat-singing and overtone music, and further evolution of Tuvan music has since been tightly linked to Western musical market. The author traces the peculiarities of such bands as “Huun Huur Tu”, “Yat-Kha”, etc. and remarks that the value of Tuvan music is not only in star performers shining on the Western skies, but in the rise of a stable community of people inspired by Tuvan music and culture, and seeking new ways of aesthetic and spiritual perception of

Estimation of the total efficiency of metabolizable energy utilization for maintenance and growth by cattle in tropical conditions Estimação da eficiência total de utilização da energia metabolizável para manutenção e crescimento por bovinos em condições tropicais

Directory of Open Access Journals (Sweden)

Douglas Sampaio Henrique

2005-06-01

Full Text Available Data of 320 animals were obtained from eight comparative slaughter studies performed under tropical conditions and used to estimate the total efficiency of utilization of the metabolizable energy intake (MEI, which varied from 77 to 419 kcal kg-0.75d-1. The provided data also contained direct measures of the recovered energy (RE, which allowed calculating the heat production (HE by difference. The RE was regressed on MEI and deviations from linearity were evaluated by using the F-test. The respective estimates of the fasting heat production and the intercept and the slope that composes the relationship between RE and MEI were 73 kcal kg-0.75d-1, 42 kcal kg-0.75d-1 and 0.37. Hence, the total efficiency was estimated by dividing the net energy for maintenance and growth by the metabolizable energy intake. The estimated total efficiency of the ME utilization and analogous estimates based on the beef cattle NRC model were employed in an additional study to evaluate their predictive powers in terms of the mean square deviations for both temperate and tropical conditions. The two approaches presented similar predictive powers but the proposed one had a 22% lower mean squared deviation even with its more simplified structure.Foram utilizadas 320 informações obtidas a partir de 8 estudos de abate comparativo conduzidos em condições tropicais para se estimar a eficiência total de utilização da energia metabolizável consumida, a qual variou de 77 a 419kcal kg-0.75d-1. Os dados também continham informações sobre a energia retida (RE, o que permitiu o cálculo da produção de calor por diferença. As estimativas da produção de calor em jejum e dos coeficientes linear e angular da regressão entre RE e MEI foram respectivamente, 73 kcal kg-0.75d-1, 42 kcal kg-0.75d-1 e 0,37. Em seguida, a eficiência total foi estimada dividindo-se a energia líquida para mantença e produção pelo consumo de energia metabolizável. A eficiência total de

Control of plant architecture by distinctive TALE homeobox gene interactions

NARCIS (Netherlands)

Bao, D.|info:eu-repo/dai/nl/304838063

2009-01-01

In eukaryotes, transcription factor (TF)-based network is a widely used mechanism to regulate fundamental developmental processes. Both animals and plants utilize three-amino-acid-loop-extension (TALE) homeodomain (HD) transcription factors to subdivide their body plan. In animals, MEIS/PBC TF

Et oksad võiksid kasvada, selleks on juuri vaja : eesti teatrikostüüm Natalie Meist tänapäevani / Kustav-Agu Püüman, Pille Jänes, Liina Unt...[jt.] ; interv. Reet Varblane

Index Scriptorium Estoniae

2000-01-01

Eesti teatrikostüümist ja Natalie Mei rollist eesti kostüümikunstis. Kostüümikunstniku rollist ja haridusest, millest oleneb õige kostüümi loomine, trendid teatrikostüümis jm. L. Blumenfeldi kommentaar saadud e-posti teel.

The influence of phase transfer catalyst structure on reaction selectivity

International Nuclear Information System (INIS)

Demlov, Eh.V.

1995-01-01

A concise review is given of systematic studies which are concerned with the tuning of regio, frequentio-, chemo-, and diastereoselectivity by the structure or type of phase transfer catalyst. Use of MEI as an alkylating agent is described. Refs. 36, figs. 11

Constructing the inclusive teacher

NARCIS (Netherlands)

Wilbert Vonck

2006-01-01

Dit paper is gepresenteerd op de slotbijeenkomst van het EU-Comenius project 'A School for All', waarvan Fontys OSO voorzitter was, op 19 mei 2006 in Tilburg. Hierin wordt, vanuit het perspectief van gelijkheid en sociale rechtvaardigheid, een profiel geschetst van de professionaliteitsopvatting

The Effects of Multiple Exemplar Instruction on the Relation between Listener and Intraverbal Categorization Repertoires

Science.gov (United States)

Lechago, Sarah A.; Carr, James E.; Kisamore, April N.; Grow, Laura L.

2015-01-01

We evaluated the effects of multiple exemplar instruction (MEI) on the relation between listener and intraverbal categorization repertoires of six typically developing preschool-age children using a nonconcurrent multiple-probe design across participants. After failing to emit intraverbal categorization responses following listener categorization…

Kõigis meis on tegelikult olemas igavene teismeline / Elen Lotman

Index Scriptorium Estoniae

Lotman, Elen

2007-01-01

25. novembrist - 2. detsembrini 2006 toimunud PÖFFi laste- ja noortefilmide festivali "Just Film" filmidest: "Wholetrain" (rezh. Florian Gaag, Saksamaa 2006), "Wassup Rockers" (rezh. Larry Clark, 2005), "Kaunitar ja kodutu" (rezh. Dome Karukoski, Soome 2005), "Karm värk" (rezh. Detlev Buck, Saksamaa 2006), kassett-film "Kõik nähtamatud lapsed" (erinevad režissöörid,. Itaalia 2005), "Seitse neitsit" (rezh. Alberto Rodrigueze, Hispaania 2007), "Pobby ja Dingani" (rezh. Peter Cattaneo, Austraalia 2006), "Me saame sellest üle" (rezh. Niels Arden Oplev, Taani 2006), "Tommy põrgu" (rezh. Ove Raymond Gyldenas, Norra), "Pilv" (rezh. Gregor Schnitzler, Saksamaa 2006)

Analysis of Schizosaccharomyces pombe Meiosis.

Science.gov (United States)

Yamashita, Akira; Sakuno, Takeshi; Watanabe, Yoshinori; Yamamoto, Masayuki

2017-09-01

Meiosis is a specialized cell cycle that generates haploid gametes from diploid cells. The fission yeast Schizosaccharomyces pombe is one of the best model organisms for studying the regulatory mechanisms of meiosis. S. pombe cells, which normally grow in the haploid state, diploidize by conjugation and initiate meiosis when starved for nutrients, especially nitrogen. Following two rounds of chromosome segregation, spore formation takes place. The switch from mitosis to meiosis is controlled by a kinase, Pat1, and an RNA-binding protein, Mei2. Mei2 is also a key factor for meiosis-specific gene expression. Studies on S. pombe have offered insights into cell cycle regulation and chromosome segregation during meiosis. Here we outline the current understanding of the molecular mechanisms regulating the initiation and progression of meiosis, and introduce methods for the study of meiosis in fission yeast. © 2017 Cold Spring Harbor Laboratory Press.

PROPORSI BANGSA, UMUR, BOBOT BADAN AWAL DAN SKOR KONDISI TUBUH SAPI BAKALAN PADA USAHA PENGGEMUKAN

Directory of Open Access Journals (Sweden)

Frandz Rumbiak Pawere

2013-03-01

Full Text Available Penelitian ini bertujuan untuk mengetahui proporsi bangsa, umur, skor kondisi tubuh sapi bakalan yang digemukkan pada usaha penggemukan. Penelitian dilaksanakan di CV. Restu Bumi, Kabupaten Bantul selama 1 tahun yakni dari bulan Mei 2011 sampai bulan Mei 2012. Materi yang digunakan adalah 500 ekor sapi meliputi bangsa sapi Limmousin Peranakan Ongole (LimPO, Peranakan Ongole (PO dan Simmental Peranakan Ongole (SimPO. Parameter yang diamati adalah bangsa, umur, body condition score (BCS. Metode analisis yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa proporsi bangsa sapi yang digemukkan-SimPO (56%, LimPO (19% dan PO (25%, umur sapi yang paling banyak digemukkan adalah poel 1 dan poel 2 masing-masing 36% dan 25%. Bobot badan awal sapi 300 kg didominasi oleh bangsa sapi silangan (SimPO dan LimPO. Nilai body condition score (BCS awal penggemukan 2-3. (Kata kunci: Bangsa, LimPO, PO, SimPO, Penggemukan

Environmental influences on the abundance and sexual composition of white sharks Carcharodon carcharias in Gansbaai, South Africa.

Directory of Open Access Journals (Sweden)

Alison V Towner

Full Text Available The seasonal occurrence of white sharks visiting Gansbaai, South Africa was investigated from 2007 to 2011 using sightings from white shark cage diving boats. Generalized linear models were used to investigate the number of great white sharks sighted per trip in relation to sex, month, sea surface temperature and Multivariate El Niño/Southern Oscillation (ENSO Indices (MEI. Water conditions are more variable in summer than winter due to wind-driven cold water upwelling and thermocline displacement, culminating in colder water temperatures, and shark sightings of both sexes were higher during the autumn and winter months (March-August. MEI, an index to quantify the strength of Southern Oscillation, differed in its effect on the recorded numbers of male and female white sharks, with highly significant interannual trends. This data suggests that water temperature and climatic phenomena influence the abundance of white sharks at this coastal site. In this study, more females were seen in Gansbaai overall in warmer water/positive MEI years. Conversely, the opposite trend was observed for males. In cool water years (2010 to 2011 sightings of male sharks were significantly higher than in previous years. The influence of environmental factors on the physiology of sharks in terms of their size and sex is discussed. The findings of this study could contribute to bather safety programmes because the incorporation of environmental parameters into predictive models may help identify times and localities of higher risk to bathers and help mitigate human-white shark interactions.

Audit Secara Prospektif terhadap Antimicrobial Stewardship Program pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang

Directory of Open Access Journals (Sweden)

Yelly Oktavia Sari

2017-12-01

Full Text Available Pembedahan yang digunakan sebagai bagian dari pengobatan kanker payudara memiliki potensi risiko infeksi karena pengaruh flora normal pada tubuh dan udara di lingkungan rawat inap. Keefektifan suatu antibiotik dipengaruhi oleh resistensi bakteri terhadap antibiotik. Tujuan penelitian ini untuk mengetahui pola bakteri, pola sensitifitas antibiotik dan pola penggunaan antibiotik pada pasien kanker payudara di bangsal bedah RSUP Dr. M. Djamil Padang pada bulan April - September 2017. Penelitian ini dilakukan secara prospektif menggunakan metode observasi yang bersifat deskriptif. Pola bakteri pada pasien ditemukan Staphylococcus aureus dan Klebsiella sp. sedangkan pada udara ditemukan bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Klebsiella sp. Berdasarkan pola sensitifitas bakteri terhadap antibiotik  selama bulan April-Mei 2017 maka yang tergolong baik (>80% adalah amoksisilin/asam klavulanat dan meropenem sementara pada bulan Agustus-September 2017 adalah meropenem. Pola sensitifitas bakteri udara selama bulan April-Mei 2017 tidak ditemukan yang tergolong baik sedangkan pada bulan Agustus-September 2017 adalah gentamisin, siprofloksasin dan meropenem. Dari total pasien sebanyak 32 orang, yang memenuhi kriteria inklusi hanya 7 orang pasien. Pola penggunaan antibiotik terbanyak pada pasien adalah seftriakson dengan jumlah 7(77,8% dan terjadi perubahan pola sensitifitas antibiotik seftriakson pada bulan April - Mei 2017 yaitu sensitif (66,7% menjadi (33,3% pada bulan Agustus-September 2017. Evaluasi kerasionalan penggunaan antibiotik, diperoleh 6(66,7% tepat obat, 9(100% tepat dosis, 7(77,8% tepat lama pemberian 9(100% tepat rute,7(100% tepat pasien dan 4(45,1% tepat indikasi serta potensi interaksi obat sebanyak 1(14,3% yaitu potensi minor.

Radioactive air emissions notice of construction for the Waste Receiving And Processing facility

International Nuclear Information System (INIS)

1993-02-01

The mission of the Waste Receiving And Processing (WRAP) Module 1 facility (also referred to as WRAP 1) includes: examining, assaying, characterizing, treating, and repackaging solid radioactive and mixed waste to enable permanent disposal of the wastes in accordance with all applicable regulations. The solid wastes to be handled in the WRAP 1 facility include low-level waste (LLW), transuranic (TRU) waste, TRU mixed wastes, and low-level mixed wastes (LLMW). Airborne releases from the WRAP 1 facility will be primarily in particulate forms (99.999 percent of total unabated emissions). The release of two volatilized radionuclides, tritium and carbon-14 will contribute less than 0.001 percent of the total unabated emissions. Table 2-1 lists the radionuclides which are anticipated to be emitted from WRAP 1 exhaust stack. The Clean Air Assessment Package 1988 (CAP-88) computer code (WHC 1991) was used to calculate effective dose equivalent (EDE) from WRAP 1 to the maximally exposed offsite individual (MEI), and thus demonstrate compliance with WAC 246-247. Table 4-1 shows the dose factors derived from the CAP-88 modeling and the EDE for each radionuclide. The source term (i.e., emissions after abatement in curies per year) are multiplied by the dose factors to obtain the EDE. The total projected EDE from controlled airborne radiological emissions to the offsite MEI is 1.31E-03 mrem/year. The dose attributable to radiological emissions from WRAP 1 will, then, constitute 0.013 percent of the WAC 246-247 EDE regulatory limit of 10 mrem/year to the offsite MEI

Evolution of bayesian-related research over time: a temporal text mining task

CSIR Research Space (South Africa)

de Waal, A

2006-06-01

Full Text Available Ronald Reagan’s Radio Addresses? Bayesian Analysis 2006, Volume 1, Number 2, pp. 189-383. 2. Mei Q and Zhai C, 2005. Discovering Evolutionary Theme Patterns from Text – An Exploration of Temporal Text Mining. KDD’05, August 21-24, 2005. Chicago...

Oksjoninäitus Vaalas

Index Scriptorium Estoniae

2003-01-01

Näitus Vaala galeriis tutvustab 20. X toimuva sügisoksjoni valikut. V. Ormissoni õlimaal "Talvemaastik tehasega" (1929-31), E. Kõksi, N. Kulli, P. Burmani, N. Mei, M. Bormeistri, L. Saartsi, V. Ohaka, A. Suumani, E. Kitse, K. Kärneri teosed. Kommentaar E. Komissarovilt

Tropical Journal of Pharmaceutical Research - Vol 15, No 3 (2016)

African Journals Online (AJOL)

Wan Wu, Wei Chen, Qiong Jin, 447-451 ... Chung-Shih Chen, Mei-Lin Wang, Rosa Huang Liu, Shih-Pin Chen, Tsong-Ming Lu, Wei-Yu Tsai, Chien-Fu Huang, ... Yan-Qiong Li, Rui Hu, Li-Hui Zhong, Qian Sun, You-Ping Yan, 527-533.

LeerKracht!

NARCIS (Netherlands)

Rinnooy Kan, Alexander; Rinnooy Kan, Alexander; Daher, Mustapha; van Es, Andrée; Frantzen, Harry; Hoffman, Rudi; Kil-Albersen, Annet; Vermeulen, Marc; ter Wal, Floor; van der Wende, Marijk

2007-01-01

Nederland staat aan de vooravond van een dramatisch kwantitatief tekort aan kwalitatief goede leraren. Dit dubbele lerarenprobleem definieert het werkterrein van de Commissie Leraren die in mei 2007 door de minister van OCW is ingesteld om te adviseren over deze fundamentele bedreiging voor de

78 FR 23866 - Airworthiness Directives; the Boeing Company

Science.gov (United States)

2013-04-23

...-200 and -300 series airplanes. The proposed AD would have required installing new operational software in the cabin management system, and loading new software into the mass memory card. Since the...., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Ray Mei, Aerospace Engineer, Systems and Equipment...

'Mastspuit met sensoren brengt middel effectiever aan' (onderzoek praktijkproeven PRI en PPO)

NARCIS (Netherlands)

Engels, A.; PPO BBF Boomkwekerij,; PRI,; Nieuwenhuizen, A.T.

2011-01-01

In mei 2011 starten Plant Research International (PRI), PPO Boomkwekerij en Damcon de eerste praktijkproeven met sensoren op de mastspuit. Dit prototype spuit alleen als het bladeren detecteert. Projectleider Ard Nieuwenhuizen van PRI is ervan overtuigd dat kwekers met zo'n type spuit middelen

Some new IIB group complexes of an imidazolidine ligand ...

Indian Academy of Sciences (India)

The spectral data indicate that the ligand is coordinated to zinc(II) as a bidentate ligand in imidazolidine form but it binds to ..... confirmed by determination of the minimum inhibitory ...... Yue F, Gang L, Xiu-Mei T, Ji-De W and Wei W 2008. Chin.

The fourteenth CRL-Salmonella workshop, 25 and 26 May 2009, Bilthoven, the Netherlands

NARCIS (Netherlands)

Mooijman KA; LZO; LIS; cib

2010-01-01

Dit rapport bevat verslagen van de presentaties die op 25 en 26 mei 2009 zijn gehouden tijdens de veertiende jaarlijkse workshop voor de Nationale Referentie Laboratoria (NRL's) voor Salmonella. Het doel van de workshop is informatie uitwisselen over activiteiten van zowel de NRL's als van het

Instorting Terminal 2e luchthaven Parijs

NARCIS (Netherlands)

Herwijnen, van F.

2008-01-01

Terminal 2E van luchthaven Charles de Gaulle, ontworpen voor de nieuwe Airbus A380, was bedoeld als kroonjuweel van Air France, maar bleek een constructieve miskleun. Mei 2004 ontstaan scheuren in het beton. Dat is de opmaat tot een kettingreactie, waarbij betonplaten, boogsegmenten en loopbruggen

Maastricht en Luik bezet : een comparatief onderzoek naar vijf aspecten van de duitse bezetting van Maastricht en Luik tijdens de tweede wereldoorlog

NARCIS (Netherlands)

Bronzwaer, Paulus Matheus Marie Antoine

2009-01-01

Dit proefschrift vergelijkt vijf aspecten van de Duitse bezetting van Luik en Maasticht van 1940-1944. Deze aspecten zijn: de Duitse inval in mei 1940; het lokale bestuur van Maastricht en Luik; de jodenvervolging in beide steden; de bevrijding in september 1944; het herstel van het democratisch

Het scheren van ooien in de laatste fase van de dracht : een verslag van drie voederproeven = Effect of shearing pregnant Flevolander ewes : three feeding trials

NARCIS (Netherlands)

Everts, H.; Kuiper, H.; Garssen, G.J.

1989-01-01

Voederproeven zijn uitgevoerd om het effect van scheren op ongeveer 8 weken voor het werpen bij Flevolander ooien te onderzoeken, die in maart of mei werpen. Hierbij waren de ruwvoeropname, het geboortegewicht van de lammeren, het gewicht van de ooien en een aantal bloedparameters de voornaamste

MerMEId

DEFF Research Database (Denmark)

Geertinger, Axel Teich; Lundberg, Sigfrid

The poster is intended to demonstrate that the MEI (Music Encoding Initiative) metadata section allows the description of musical works, including their history and sources, in such detail that it can serve as the basis for entire thematic catalogues or to collect source information for use...

African Journal of Biotechnology - Vol 10, No 26 (2011)

African Journals Online (AJOL)

Estimation of biochemical variables using quantumbehaved particle swarm optimization (QPSO)-trained radius basis function neural network: A case study of fermentation process of L-glutamic acid · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Z Liao, C Mei, 5203- ...

Workshop #7 Toentje: Stakeholder Canvas

NARCIS (Netherlands)

Levelt, M.

2017-01-01

Op vrijdag 19 mei vond alweer de zevende R-LINK Workshop plaats tijdens de driedaagse in Groningen. In de voormalige drankenfabriek van de Firma Woldring en Idema aan de Paradijsvogelstraat zaten onderzoekers samen met betrokkenen van Toentje, Bie de Buuf en de Oosterparkwijk om tafel in

Lean leadership and change management skills

NARCIS (Netherlands)

Frank Willems

2013-01-01

Gastcollege Masteropleiding MIM Tilburg University/TiasNimbas Business School op 17 & 18 mei 2013. • Basic principles of Change Management • Group practice • TheoryU and Social Networking theory as framework for Leadership • Theory about Lean thinking as a method for improving Leadership skills and

Distribution of meiofaunal abundances in a marine cave complex with secondary openings and freshwater filtrations

DEFF Research Database (Denmark)

Riera, Rodrigo; Monterroso, Óscar; Núñez, Jorge

2018-01-01

Submerged sea caves are priority areas for conservation according to the Habitat Directive 92/43/CEE because of their unique biodiversity. A limited number of publications exist about communities living on sediments inside caves, mostly focused on the macrofaunal fraction (>0.5-mm body size). Mei...

Vrede-, Bevrijding- en Vrijheid-verhalen op locatie – augmented reality en navigatie applicatie op smart phones

NARCIS (Netherlands)

Lammeren, van R.J.A.; Bergsma, A.R.; Franke, G.J.

2010-01-01

In de periode december 2009 - mei 2010 is de applicatie Vrede, Bevrijding en Vrijheid ontwikkeld. Deze applicatie biedt gebruikers van smart phones met draadloos internet, zoals Android-phones en iPhones, de mogelijkheid om op locatie verhalen te luisteren, te lezen en te bekijken. Dit verslag

Supporting Health by Technology

NARCIS (Netherlands)

Laurence Alpay

2015-01-01

Congres: 22 mei in Twente. Het thema van dit jaar was: "Designing Persuasive Tech for Health" 3D visualization tools bieden interessante mogelijkheden op het terrein van persuasieve technologie. In deze context was DAVE de "Pratende CT-scan" bij het congres aanwezig. DAVE geeft zelf uitleg over

De Franse aardkastanje [Conopodium majus (Gouan) Loret] nadert de Nederlandse grenzen

NARCIS (Netherlands)

Weeda, E.J.

1993-01-01

Op 14 mei 1988 toonde Onno de Bruijn me bij Bentheim in Nedersaksen een aantal planten van een Schermbloemige, die daar door enkele Twentse floristen waren opgemerkt en die niet met zekerheid op naam konden worden gebracht. Aanvankelijk dachten we aan Meum athamanticum (wat in vergelijkbare gevallen

SOA-surveillance Nederland

NARCIS (Netherlands)

Rijlaarsdam J; Bosman A; Laar MJW van de; CIE

2000-01-01

In mei 1999 is een werkgroep gestart met de opdracht om "vanuit de bestaande situatie een voorstel te doen voor een effectief en efficient surveillancesysteem voor SOA dat inzicht geeft in de prevalentie en de incidentie van SOA in Nederland. Het systeem moet te gebruiken zijn voor directe

Notulen

Directory of Open Access Journals (Sweden)

Redactie KITLV

1952-10-01

Full Text Available Bestuursvergadering van 19 Januari 1952; Bestuursvergadering van 16 Februari 1952; Bestuursvergadering van 15 Maart 1952; Bestuursvergadering van 17 Mei 1952; Bestuursvergadering van 21 Juni 1952; Bestuursvergadering van 8 September 1952; Bestuursvergadering van 20 September 1952; Bestuursvergadering van 18 October 1952; Algemene vergadering van 15 Maart 1952

Evaluation of effectiveness in a novel wound healing ointment ...

African Journals Online (AJOL)

Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen ...

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. Chen Bin1 Zeng Zhirong1 Wu Xiaoqin1 Chen Minhu1 Li Mei1 Gao Xiang1 Chen Baili1 Hu Pinjin1. Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of China ...

Verslag 20th Symposium on Housing and Fiseases of Rabbits, Furprovinding animals and Pet animals

NARCIS (Netherlands)

Rommers, J.M.

2017-01-01

Op 17 en 18 mei jl. werd in Celle (Duitsland) het Symposium on Housing
and Diseases of Rabbits, Furproviding animals and Pet animals
gehouden. Dit symposium wordt eenmaal per twee jaar georganiseerd
door Duitsland. Er waren circa 60 deelnemers uit 12 verschillende
landen, waaronder

Tam tam in de polder: uitbreiding Afrikamuseum Berg en Dal door Rijksgebouwdienst

NARCIS (Netherlands)

Voorthuis, J.C.T.

2006-01-01

Op 27 mei dit jaar is in het glooiende boslandschap van Berg en Dal, vlak bij Nijmegen, de nieuwe uitbreiding van het Afrika Museum geopend. Het ontwerp is in vele opzichten voorbeeldig. Het stelt zich terughoudend op ten aanzien van zowel de schitterende omgeving als het doel - het tentoonstellen

Tropical Journal of Pharmaceutical Research - Vol 14, No 11 (2015)

African Journals Online (AJOL)

Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, ...

42 CFR 405.504 - Determining prevailing charges.

Science.gov (United States)

2010-10-01

... the increase in earnings (less increases in workers' productivity was 110 percent over the earnings... index of labor productivity in the nonfarm business sector. (2) The MEI is constructed, using as a base...-farm business sector labor productivity. (3) If there is no methodological change, CMS publishes a...

Addendum waarde commerciële radiovergunningen

NARCIS (Netherlands)

Poort, J.; Kerste, M.; Akker, I.; Prins, J.

2011-01-01

Op 18 mei 2010 stuurde de Minister van Economische Zaken het SEO-rapport Waarde commerciële radiovergunningen naar de Tweede Kamer. Dat rapport doet verslag van een onderzoek naar de waarde van de commerciële radiovergunningen. Het vormde de grondslag voor het financieel instrument in de

Reisverslag India 2009

NARCIS (Netherlands)

Velthuijsen, Hugo

2009-01-01

Verslag van een bezoek in mei 2009 aan India als onderdeel van een delegatie van KPN. In een week werden bezoeken gebracht aan 7 IT leveranciers van KPN, 3 universiteiten en waren er gesprekken met diverse andere partijen. Daarbij zijn de steden Mumbai, Pune, Bangalore en Chennai aangedaan. Dit

Arnold Roosendaal, Digital Personae and Profiles in Law. Protecting Individuals’ Rights in Online Contexts [Bespreking van: Digital Personae and Profiles in Law

NARCIS (Netherlands)

Lodder, A.R.

2014-01-01

Op 21 mei 2013 verdedigde Arnold Roosendaal aan de Universiteit Tilburg zijn proefschrift Digital Personae and Profiles in Law, promotoren waren Ronald Leenes en Bert-Jaap Koops. In de openingszin wordt het belang van het proefschrift direct duidelijk: “Personal data is the new oil of the Internet

Korte mededelingen

NARCIS (Netherlands)

NN,

1965-01-01

Klemdraai bij Equisetum arvense L. — Fig. 1. Van het Natuurhistorisch Museum te Maastricht ontvingen wij hit hier afgebeelde exemplaar van Equisetum arvense L., dat gevonden werd bij Bemelen in mei 1965 door de heer E. de Grood, Heer, L. Een foto ervan werd reeds gepubliceerd in het Natuurhistorisch

Wageningse kennis(sen): doe er wat mee in het groene onderwijs

NARCIS (Netherlands)

Goud, J.C.; Lans, T.

2011-01-01

Op 25 mei 2011 organiseerde WUR in Ede de KennisMaakDag. Centraal stonden een groot aantal projecten die mede waren gefinancierd door het fonds WUR Knowledge Sharing (WURKS) en vanuit het beleidsondersteunend onderzoek (BO), maar ook voor andere initiatieven was aandacht. We staan nader stil bij de

Meiose e viabilidade polínica em acessos de Capsicum annuum e Capsicum baccatum Meiosis and pollen viability in accessions of Capsicum annuum and Capsicum baccatum

Directory of Open Access Journals (Sweden)

Kellen Coutinho Martins

2010-08-01

Full Text Available O objetivo deste trabalho foi estudar o comportamento meiótico e a viabilidade polínica em quatro acessos das espécies Capsicum annuum e Capsicum baccatum. Em todos os acessos, foram observados 12 bivalentes, confirmando o número e nível de ploidia relatados na literatura para essas espécies. Os resultados mostraram uma divisão celular normal, porém algumas anormalidades foram detectadas, tais como migração precoce dos cromossomos em metáfases I e II, cromossomos retardatários em anáfase I e divisão assincrônica. Os acessos estudados apresentaram um índice meiótico variando de 75,6 a 93,6%, e a viabilidade polínica em todos os acessos foi superior a 90%, demonstrando que as irregularidades meióticas observadas não comprometeram a viabilidade destes.The objective of this research was to study the meiotic behavior and pollen viability in four accessions of species Capsicum annuum and Capsicum baccatum. In all accessions, twelve bivalents were observed, confirming the number and ploidy level reported in the literature for these species. The results showed a normal cell division although some abnormalities had been detected, as early chromosome migration at metaphases I and II, later chromosomes at anaphase I and asynchronous division. The studied accessions presented a meiotic index (MI that varied from 75.6 to 93.6% and the pollen viability in all accessions was higher than 90%, demonstrating that the meiotic irregularities observed didn't affect their viability.

Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling.

Science.gov (United States)

Guo, Boliang; Kaylor-Hughes, Catherine; Garland, Anne; Nixon, Neil; Sweeney, Tim; Simpson, Sandra; Dalgleish, Tim; Ramana, Rajini; Yang, Min; Morriss, Richard

2017-09-01

The Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument for measuring levels of depression in patients in clinical practice and academic research; its factor structure has been investigated in various samples, with limited evidence of measurement equivalence/invariance (ME/I) but not in patients with more severe depression of long duration. This study aims to explore the factor structure of the PHQ-9 and the ME/I between treatment groups over time for these patients. 187 secondary care patients with persistent major depressive disorder (PMDD) were recruited to a randomised controlled trial (RCT) with allocation to either a specialist depression team arm or a general mental health arm; their PHQ-9 score was measured at baseline, 3, 6, 9 and 12 months. Exploratory Structural Equational Modelling (ESEM) was performed to examine the factor structure for this specific patient group. ME/I between treatment arm at and across follow-up time were further explored by means of multiple-group ESEM approach using the best-fitted factor structure. A two-factor structure was evidenced (somatic and affective factor). This two-factor structure had strong factorial invariance between the treatment groups at and across follow up times. Participants were largely white British in a RCT with 40% attrition potentially limiting the study's generalisability. Not all two-factor modelling criteria were met at every time-point. PHQ-9 has a two-factor structure for PMDD patients, with strong measurement invariance between treatment groups at and across follow-up time, demonstrating its validity for RCTs and prospective longitudinal studies in chronic moderate to severe depression. Copyright © 2017. Published by Elsevier B.V.

DISTRIBUSI, KELIMPAHAN DAN VARIASI UKURAN LARVA IKAN DI ESTUARIA SUNGAI MUSI

Directory of Open Access Journals (Sweden)

Eko Prianto

2016-03-01

Full Text Available Penelitian tentang distribusi, kelimpahan dan ukuran larva ikan dilakukan pada bulan Maret, Mei, Juni dan Oktober 2011. Stasiun pengambilan contoh meliputi Muara Delta Upang (stasiun 1, Muara Sungai Musi (stasiun 2 dan Pulau Payung (stasiun 3. Pengambilan larva pada siang hari menggunakan Bongo net yang berukuran mata jaring 250 µm. Hasil identifikasi diperoleh 13 famili ditinjau menurut musim, pada bulan Mei dan Oktober masing-masing diperoleh 7 famili, dan pada bulan juni sebanyak 3 famili. Kelimpahan larva ikan berkisar antara 9-46 ind/m3 dengan jumlah yang tertinggi (46 ind/m3 pada bulan Mei dan terendah pada bulan Juni (9 ind/m3. Larva ikan dari famili Gobiidae memiliki sebaran yang cukup luas baik spasial maupun temporal. Variasi ukuran larva ikan menurut famili setiap bulannya memiliki variasi ukuran yang hampir sama.  Research about the distribution, abundance and size of fish larvae was conducted in March, May, June and October 2011. Sampling stations encompasses Delta Upang (station 1, Muara Sungai Musi (station 2 and Pulau Payung (station 3. Larvae taken during the daytime using a Bongo net with mesh size of 250 µm. Identification results obtained 13 families based on the season, in May and October respectively 7 families, and in June as many as 3 families. Abundance of fish larval around 9-46 ind/m3 with the highest number (46 ind/m3 in May and the lowest in June (9 ind/m3. Larvae of Gobiidae family have a large distribution on spatial and temporal. The variation in size of fish larvae by family on each month are the same.

RADIONUCLIDE AIR EMISSIONS REPORT FOR THE HANFORD SITE CY2003

International Nuclear Information System (INIS)

ROKKAN, D.J.

2004-01-01

This report documents radionuclide air emissions from the US Department of Energy (DOE) Hanford Site in 2003 and the resulting effective dose equivalent (EDE) to the maximally exposed individual (MEI) member of the public. The report has been prepared in accordance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants, Subpart H, ''National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities''; Washington Administrative Code (WAC) Chapter 246-247, ''Radiation Protection-Air Emissions''; 10 CFR 830.120, Quality Assurance; DOE Order 414.1B, Quality Assurance; NQA-1, Quality Assurance Requirements for Nuclear Facility Application; EPA QA/R-2, EPA Requirements for Quality Management Plans; and EPA QA/R-5, Requirements for Quality Assurance Project Plans. The federal regulations in Subpart H of 40 CFR 61 require the measurement and reporting of radionuclides emitted from DOE facilities and the resulting public dose from those emissions. A standard of 10 mrem/yr EDE is not to be exceeded. The EDE to the MEI due to routine and nonroutine emissions in 2003 from Hanford Site point sources was 0.022 mrem (0.00022 mSv), or 0.22 percent of the federal standard. The portions of the Hanford Site MEI dose attributable to individual point sources as listed in Section 2.0 are appropriate for use in demonstrating the compliance of abated stack emissions with applicable terms of the Hanford Site Air Operating Permit and of Notices of Construction. The state has adopted the 40 CFR 61 standard of 10 mrem/yr EDE into their regulations, yet further requires that the EDE to the MEI be calculated not only from point source emissions but also from diffuse and fugitive sources of emissions. WAC 246-247 also requires the reporting of radionuclide emissions from all Hanford Site sources during routine as well as nonroutine operations. The EDE from

kerkleierskap as bemiddeling van 'n onmoontlike werklikheid: 'n ...

African Journals Online (AJOL)

19 Mei 2010 ... Chaos is 'n kritieke deel van die proses waardeur organisasies voortdurend op hul eksterne omgewing inspeel. In 'n sekere sin vrees elke leier chaos, omdat chaos 'n verlies aan beheer veronderstel. (In die Newtoniaanse wêreld van orde en beheer, is beheer immers 'n noodsaaklike meganisme.) Flower ...

75 FR 59290 - In the Matter of Certain Liquid Crystal Display Devices and Products Interoperable With the Same...

Science.gov (United States)

2010-09-27

... parties upon which the complaint is to be served: Sony Corporation, 1-7-1, Konan, Minato-ku, Tokyo, Japan; Sony Corporation of America, 550 Madison Ave., New York, NY 10022; Sony Electronics Corporation, 16530... Innolux Corporation of Taiwan; Chi Mei Optoelectronics U.S.A., Inc. of San Jose, California; and Innolux...

Post-launch monitoring of novel foods/ingredients (revised version) : Methodology applied to additive stevia

NARCIS (Netherlands)

Brosens M; Hendriksen M; Niekerk EM; Temme EHM; van Raaij JMA; P&V; V&Z

2014-01-01

Dit rapport is de herziene versie van het oorspronkelijke rapport (mei 2014). Op pagina 3 staat een erratum met uitleg over de wijzigingen

Het RIVM heeft een methode ontwikkeld waarmee in kaart kan worden gebracht welke producten een bepaald ingrediënt bevatten, en zo ja in welke

The Two-Word Stage: Motivated by Linguistic or Cognitive Constraints?

Science.gov (United States)

Berk, Stephanie; Lillo-Martin, Diane

2012-01-01

Child development researchers often discuss a "two-word" stage during language acquisition. However, there is still debate over whether the existence of this stage reflects primarily cognitive or linguistic constraints. Analyses of longitudinal data from two Deaf children, Mei and Cal, not exposed to an accessible first language (American Sign…

The Physics and Operation of Ultra-Submicron Length Semiconductor Devices.

Science.gov (United States)

1994-05-01

300 mei heterostructure diode at T=3001( with Fenni statistics and flat band conditions In all of the calculations with a heterostructure barrier, once...25 24- 22- 21- 0 50 100 150 200 Obhnce (mre Figure 8. Self-consistent T=300K calculation with Fenni statistics showing the density and donor

Will Television Bring Us This?

African Journals Online (AJOL)

25 Mei 1974 ... In October 1973 viewers of a popular show on. BBC television in the UK were given unequivocal statements about the treatment of rheumatic disease and advice on treatment recommending a 'prescrip- tion only' drug recently introduced to that market. The use of the medium to advise specific anti-.

MEMS Lens Scanners for Free-Space Optical Interconnects

Science.gov (United States)

2011-12-15

electrothermal linear micromotors ,” Journal of Micromechanics and Microengineering, vol. 14, no. 2, pp. 226– 234, 2004. [59] Hyuck Choo and R. S. Muller...84] Mei Lin Chan et al., “Low friction liquid bearing mems micromotor ,” in 2011 IEEE 24th International Conference on Micro Electro Mechanical

American Peptide Symposium Proceedings (13th) Held in Edmonton, Alberta, Canada on June 20-25, 1993. Peptides: Chemistry, Structure and Biology

Science.gov (United States)

1993-06-20

protein . rceloMEIS w-mdeimidobenzol UtMA I,-Nfoer N-hydroxy- SONaY succinimide ester iniraioa units 14CM melanin concentrating luM keyhole limpet MCPSA...cyclic depsipeptide aureobasidin A (1), isolated as a major component from the culture medium of the black yeast Aureobasidium puUukans R 106, exhibits

Swerwende verse | Cloete | Tydskrif vir letterkunde

African Journals Online (AJOL)

Iliad by Homer, the mystifying Secret History of the Mongols by an unknown author, and the Dutch poem Mei by Herman Gorter. Keywords: Comparative literature, global character of literature, Achnaton, Homer, Herman Gorter, Secret History of the Mongols, Psalms. > Tydskriff vir Letterkunde Vol. 44 (2) 2007: pp. 46-61 ...

Selectie van Italiaanse werkwoordsvormen op basis van frequentieonderzoek

NARCIS (Netherlands)

Boer, M.G. de

2009-01-01

SAMENVATTING Dit artikel is een vroege recensie (mei 1972) van het LIF, de frequentielijst van IBM Italia uit 1971. De auteur concentreert zich op de verschillen met het project van Juilland, dat als uitgangspunt voor het LIF heeft gefungeerd. Op grond van de gegevens van het LIF is een basislijst

Case-mix classificatie als basis voor bekostiging van wijkverpleging : Een verkennend onderzoek in opdracht van MeanderGroep Zuid-Limburg

NARCIS (Netherlands)

Elissen, Arianne; Metzelthin, Silke; van den Bulck, Anne; Verbeek, Hilde; Ruwaard, Dirk

2017-01-01

n opdracht van MeanderGroep Zuid‐Limburg is tussen mei 2016 en april 2017 door de Universiteit Maastricht een verkennend onderzoek uitgevoerd naar de relatie tussen cliëntkenmerken en het gebruik en de kosten van wijkverpleging. Doel is om een bijdrage te leveren aan de ontwikkeling van een nieuwe

Whither Radiology?

African Journals Online (AJOL)

15 Mei 1974 ... Computerised transverse axial scanning (CTAS) was first reported in ... to produce a series of images by a tomographic method, and ... mother and/or child is in danger, should the ex- amination be ... units to eliminate unnecessary expenditure on equipment ... I. Arnbrose, J. and Hounsfield. G. (1973): Brit.

Application of calcifying bacteria for remediation of stones and cultural heritages.

Science.gov (United States)

Dhami, Navdeep Kaur; Reddy, M Sudhakara; Mukherjee, Abhijit

2014-01-01

Since ages, architects and artists worldwide have focused on usage of durable stones as marble and limestone for construction of beautiful and magnificent historic monuments as European Cathedrals, Roman, and Greek temples, Taj Mahal etc. But survival of these irreplaceable cultural and historical assets is in question these days due to their degradation and deterioration caused by number of biotic and abiotic factors. These causative agents have affected not only the esthetic appearance of these structures, but also lead to deterioration of their strength and durability. The present review emphasizes about different causative agents leading to deterioration and application of microbially induced calcium carbonate precipitation as a novel and potential technology for dealing with these problems. The study also sheds light on benefits of microbial carbonate binders over the traditional agents and future directions.

Inženiersistēmu tehniskie un estētiskie aspekti interjerā

OpenAIRE

Kārkliņa, Santa

2016-01-01

Lai radītu komfortablu sabiedrisko telpu ēdināšanas vajadzībām, ir jāņem vērā daudzi un dažādi faktori, visupirms sākot ar telpas funkciju noteikšanas un apmierināšanas, kurām paredzēta telpa, beidzot ar inženiertehniskajiem, koloristiskajiem un apgaismojuma risinājumiem. Ir svarīgi, lai visām telpām būtu skaidri nolasāma funkcija un plānojums, lai lieki telpu nesaraibinātu un neradītu tajā esošajiem cilvēkiem lieku apjukumu. Ņemot vērā, ka nereti telpas, kurās ir jāprojektē interjers, paliek...

Personal and ambient PM2.5 exposure assessment in the city of Agra

Directory of Open Access Journals (Sweden)

M. Habil

2016-03-01

Full Text Available Human exposure to fine particles can have significant harmful effects on the respiratory and cardiovascular system. To investigate daily exposure characteristics to PM2.5 with ambient concentrations in an urban environment, a personal exposure measurements were conducted for school children, office workers and at their residents, in the city of Taj ‘Agra’, India. In order to account for all the sources of particulate matter exposure, measurements on several different days during December 2013 to February 2014 were carried out. Personal environment monitors (PEM and APM 550 were used to measure PM2.5 concentration. The research findings provide insight into possible sources and their interaction with human activities in modifying the human exposure levels. Keywords: Personal exposure, PM2.5, Ambient concentration, Correlation analysis, Health effects

Dzimumu līdztiesība darba tirgū vērsta uz sieviešu tiesībām Latvijā un Amerikas Savienotajās Valstīs

OpenAIRE

Grandaua, Monta

2017-01-01

Grandaua M. Dzimumu līdztiesība darba tirgū vērsta uz sieviešu tiesībām Latvijā un ASV: diplomdarbs. Rīga: Latvijas Universitātes Biznesa, vadības un ekonomikas fakultāte, 2017. 89 lpp. Tajā iekļautas 7 tabulas, 19 attēli un izmantotā literatūra ietver 74 avotus. Dzimumu nevienlīdzība ir aspekts, kas ietekmē daudzas valstis. ASV valda samērā liela dzimumu nevienlīdzība, it īpaši darba samaksas jautājumā – vīrieši par vienu un to pašu darbu saņem vairāk nekā sievietes. Latvijā savukārt dzimumu...

Programmēšanas valodas Java 8 iespējas

OpenAIRE

Vaivars, Arnis

2014-01-01

Java ir viena no pasaulē populārākajām objektorientētajām programmēšanas valodām. Šī platforma ir nepārtraukti attīstīta un pilnveidota, ar katru versiju sniedzot programmatūras izstrādātājiem jaunas iespējas. 2014.gada martā tika izplatīta uz darba izstrādes brīdi jaunākā platformas versija – Java 8. Pateicoties lambda izteiksmēm, Nashorn Javascript dzinējam, jaunajām datuma, laika un straumju lietojumprogrammu saskarnēm un citām iespējām, šis laidiens iespējams ir pati gaidītākā Java versij...

African Journal of Traditional, Complementary and Alternative ...

African Journals Online (AJOL)

Li-Long Liu, Kai Xu, Lu-Mei Kang, Shu-Ping Jiang, Qing-Hua Wang, Lei Zhang, Shao-Gui Wan, Hong-Ping Chen, 113-121 ... Cytological effects of pulsed electromagnetic fields and static magnetic fields induced by a therapeutic device on in vivo exposed rats · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

Ontwikkelingen in het EU-recht: Uber een vervoersaanbieder

NARCIS (Netherlands)

de Vries-Stotijn, Anne

2018-01-01

In twee recente zaken voor het Hof van Justitie concludeert A-G Szpunar dat taxi-applicatie Uber kwalificeert als aanbieder van vervoersdiensten. (Asociación Profesional Elite Taxi Zaak C-434/15, conclusie 11 mei 2017 ECLI:EU:C:2017:364 en Uber/France SAS Zaak C-320/16, conclusie 4 juli 2017

Browse Title Index

African Journals Online (AJOL)

Items 51 - 100 of 1309 ... Li-Long Liu, Kai Xu, Lu-Mei Kang, Shu-Ping Jiang, Qing-Hua Wang, ... CR Sewani-Rusike, JE Iputo, EJ Ndebia, M Gondwe, DR Kamadyaapa ... K-M Man, W-C Chen, H-M Wang, H-Y Chen, J-L Shen, L-D Chen, F-J Tsai, ...

US Army Conventional Forces in Gray Zone Conflict

Science.gov (United States)

2017-05-25

Heritage Foundation, 2016 Index of U.S. Military Strength, accessed October 2, 2016, http://index.heritage.org/military/2016/assessments/. 5 Sun - Tzu ...NJ: Princeton University Press, 1986. Sun - Tzu , Ralph D. Sawyer, and Mei-Chün Sawyer. The Art of War. New York: Barnes & Noble, 1994. Tellis... Bibliography ...................................................................................................................................... 40 v

Rahvuspaviljon kui lakmuspaber / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2003-01-01

50. Veneetsia biennaal "Unistused ja konfliktid". Kuraator Francesco Bonami. Võrdlus 49. Veneetsia biennaaliga. Šveitsi paviljonis näidatud Emanuelle Antille'i filmist "Angels Camp", iisraeli kunstniku Michal Rovneri ja Luksemburgi esindava Su-Mei Tse (rahvusväljapaneku preemia) ruumist, Eesti väljapanekust "Marko und Kaido" - Marko Mäetamm ja Kaido Ole

Identification of a novel SHOX mutation in a Chinese family with ...

Indian Academy of Sciences (India)

[Mei L., Huang Y., Pan Q., Li H., Liang D. and Wu L. 2014 Identification of a novel SHOX mutation in a Chinese family with isolated. Madelung deformity. J. Genet. ... females than males (Lichtenstein et al. 1980; Grigelioniene et al. 2001). .... proteins play critical roles in controlling the embryonic development in vertebrates ...

Mööbel, mis äratab meis lapse / Ele Praks

Index Scriptorium Estoniae

Praks, Ele

2004-01-01

Leidlikke mööbliesemeid maailmast lastetuppa, mille autoriteks Ieva Araja ja Rihards Funts Lätist, Samantha Parsons Austraaliast, Peter Murdoch jt. Artiklis ka kodulehekülgede aadresse, kust leida toredaid istmeid ja laudu

Anomalias meióticas de oócitos de pacientes com endometriose submetidas à estimulação ovariana Meiotic abnormalities of oocytes from patients with endometriosis submitted to ovarian stimulation

Directory of Open Access Journals (Sweden)

Ionara Diniz Evangelista Santos Barcelos

2008-08-01

Full Text Available OBJETIVO: avaliar o fuso meiótico e a distribuição cromossômica de oócitos maturados in vitro, obtidos de ciclos estimulados de mulheres inférteis com endometriose e fatores masculino e/ou tubário de infertilidade (Grupo Controle, comparando as taxas de maturação in vitro (MIV entre os dois grupos avaliados. MÉTODOS: quatorze pacientes com endometriose e oito com fator tubário ou masculino, submetidas à estimulação ovariana para injeção intracitoplasmática de espermatozóide, foram selecionadas, prospectiva e consecutivamente, e constituíram os Grupos de Estudo e Controle, respectivamente. Oócitos imaturos (46 e 22, respectivamente, dos Grupos Endometriose e Controle foram submetidos à MIV. Oócitos que apresentaram a extrusão do primeiro corpúsculo polar foram fixados e corados para avaliação dos microtúbulos e cromatina por técnica de imunofluorescência. A análise estatística foi realizada utilizando o teste exato de Fisher, com significância estatística quando pPURPOSE: to evaluate the meiotic spindle and the chromosome distribution of in vitro mature oocytes from stimulated cycles of infertile women with endometriosis, and with male and/or tubal infertility factors (Control Group, comparing the rates of in vitro maturation (IVM between the two groups evaluated. METHODS: fourteen patients with endometriosis and eight with male and/or tubal infertility factors, submitted to ovarian stimulation for intracytoplasmatic sperm injection have been prospectively and consecutively selected, and formed a Study and Control Group, respectively. Immature oocytes (46 and 22, respectively, from the Endometriosis and Control Groups were submitted to IVM. Oocytes presenting extrusion of the first polar corpuscle were fixed and stained for microtubules and chromatin evaluation through immunofluorescence technique. Statistical analysis has been done by the Fisher's exact test, with statistical significance at p<0.05. RESULTS

Lessons learned from a great master!

Directory of Open Access Journals (Sweden)

Wagner Seixas da Silva

2015-06-01

Full Text Available Teaching Biochemistry is a huge challenge in the basic cycle of many undergraduate courses. How to convince students that this discipline is important for their academic degree so early in their college journeys? It may be hard to define in words a good teaching strategy for this purpose, but during the 70s'/80's a group of professors accepted this tough task! Professor Leopoldo de Meis paid particular attention to the way of teaching biochemistry. As a very sensitive person, he realized that the secret to a good teaching would be to keep the students motivated with doses of challenge.With this in mind, Prof. de Meis joined a small group of professors and graduate students from the former Department of Medical Biochemistry, now named Institute of Medical Biochemistry Leopoldo de Meis, at the Federal University of Rio de Janeiro, and proposed to use the Discovery learning method in classroom. The idea was to present the contents of the biochemistry course while challenging students to interpret the original data of the major biochemical findings. For this purpose, each biochemistry theme was shown through the experiments that led to the originally obtained conclusions currently present in the textbooks. Thus, students were motivated to ask questions and propose experiments that allow the interpretation of the scientists’ historical results. At first the methodology seemed very novel and difficult, but over the first few minutes the environment became a place for broad scientific discussion, where students enthusiastically participated and developed the ability to draw up the necessary questions to decipher the functioning of metabolic pathways. The parallel between the observed experimental facts and the physiological state of the experimental model used in classic experiments permitted the development of a broad and critical knowledge in the learning of biochemistry.To imagine that the students were motivated to develop the autonomy of

The Response of African Land Surface Phenology to Large Scale Climate Oscillations

Science.gov (United States)

Brown, Molly E.; de Beurs, Kirsten; Vrieling, Anton

2010-01-01

Variations in agricultural production due to rainfall and temperature fluctuations are a primary cause of food insecurity on the African continent. Analysis of changes in phenology can provide quantitative information on the effect of climate variability on growing seasons in agricultural regions. Using a robust statistical methodology, we describe the relationship between phenology metrics derived from the 26 year AVHRR NDVI record and the North Atlantic Oscillation index (NAO), the Indian Ocean Dipole (IOD), the Pacific Decadal Oscillation (PDO), and the Multivariate ENSO Index (MEI). We map the most significant positive and negative correlation for the four climate indices in Eastern, Western and Southern Africa between two phenological metrics and the climate indices. Our objective is to provide evidence of whether climate variability captured in the four indices has had a significant impact on the vegetative productivity of Africa during the past quarter century. We found that the start of season and cumulative NDVI were significantly affected by large scale variations in climate. The particular climate index and the timing showing highest correlation depended heavily on the region examined. In Western Africa the cumulative NDVI correlates with PDO in September-November. In Eastern Africa the start of the June-October season strongly correlates with PDO in March-May, while the PDO in December-February correlates with the start of the February-June season. The cumulative NDVI over this last season relates to the MEI of March-May. For Southern Africa, high correlations exist between SOS and NAO of September-November, and cumulative NDVI and MEI of March-May. The research shows that climate indices can be used to anticipate late start and variable vigor in the growing season of sensitive agricultural regions in Africa.

Radionuclide Air Emission Report for 2009

Energy Technology Data Exchange (ETDEWEB)

Wahl, Linnea

2010-06-01

Berkeley Lab operates facilities where radionuclides are handled and stored. These facilities are subject to the EPA radioactive air emission regulations in 40CFR61, Subpart H (EPA 1989). Radionuclides may be emitted from stacks or vents on buildings where radionuclide production or use is authorized or they may be emitted as diffuse sources. In 2009, all Berkeley Lab sources were minor sources of radionuclides (sources resulting in a potential dose of less than 0.1 mrem/yr [0.001 mSv/yr]). These minor sources included more than 100 stack sources and one source of diffuse emissions. There were no unplanned emissions from the Berkeley Lab site. Emissions from minor sources (stacks and diffuse emissions) either were measured by sampling or monitoring or were calculated based on quantities used, received for use, or produced during the year. Using measured and calculated emissions, and building-specific and common parameters, Laboratory personnel applied the EPA-approved computer code, CAP88-PC, to calculate the effective dose equivalent to the maximally exposed individual (MEI). The effective dose equivalent from all sources at Berkeley Lab in 2009 is 7.0 x 10{sup -3} mrem/yr (7.0 x 10{sup -5} mSv/yr) to the MEI, well below the 10 mrem/yr (0.1 mSv/yr) dose standard. The location of the MEI is at the University of California (UC) Lawrence Hall of Science, a public science museum about 1500 ft (460 m) east of Berkeley Lab's Building 56. The estimated collective effective dose equivalent to persons living within 50 mi (80 km) of Berkeley Lab is 1.5 x 10{sup -1} person-rem (1.5 x 10{sup -3} person-Sv) attributable to the Lab's airborne emissions in 2009.

Quantitative considerations in medium energy ion scattering depth profiling analysis of nanolayers

Energy Technology Data Exchange (ETDEWEB)

Zalm, P.C.; Bailey, P. [International Institute for Accelerator Applications, University of Huddersfield, Queensgate, Huddersfield HD1 3DH (United Kingdom); Reading, M.A. [Physics and Materials Research Centre, University of Salford, Salford M5 4WT (United Kingdom); Rossall, A.K. [International Institute for Accelerator Applications, University of Huddersfield, Queensgate, Huddersfield HD1 3DH (United Kingdom); Berg, J.A. van den, E-mail: j.vandenberg@hud.ac.uk [International Institute for Accelerator Applications, University of Huddersfield, Queensgate, Huddersfield HD1 3DH (United Kingdom)

2016-11-15

The high depth resolution capability of medium energy ion scattering (MEIS) is becoming increasingly relevant to the characterisation of nanolayers in e.g. microelectronics. In this paper we examine the attainable quantitative accuracy of MEIS depth profiling. Transparent but reliable analytical calculations are used to illustrate what can ultimately be achieved for dilute impurities in a silicon matrix and the significant element-dependence of the depth scale, for instance, is illustrated this way. Furthermore, the signal intensity-to-concentration conversion and its dependence on the depth of scattering is addressed. Notably, deviations from the Rutherford scattering cross section due to screening effects resulting in a non-coulombic interaction potential and the reduction of the yield owing to neutralization of the exiting, backscattered H{sup +} and He{sup +} projectiles are evaluated. The former mainly affects the scattering off heavy target atoms while the latter is most severe for scattering off light target atoms and can be less accurately predicted. However, a pragmatic approach employing an extensive data set of measured ion fractions for both H{sup +} and He{sup +} ions scattered off a range of surfaces, allows its parameterization. This has enabled the combination of both effects, which provides essential information regarding the yield dependence both on the projectile energy and the mass of the scattering atom. Although, absolute quantification, especially when using He{sup +}, may not always be achievable, relative quantification in which the sum of all species in a layer adds up to 100%, is generally possible. This conclusion is supported by the provision of some examples of MEIS derived depth profiles of nanolayers. Finally, the relative benefits of either using H{sup +} or He{sup +} ions are briefly considered.

Potential of gadolinium as contrast material in second generation dual energy computed tomography - An ex vivo phantom study.

Science.gov (United States)

Bongers, Malte N; Schabel, Christoph; Krauss, Bernhard; Claussen, Claus D; Nikolaou, Konstantin; Thomas, Christoph

To evaluate the potential of gadolinium (Gd) as contrast material (CM) in second generation dual energy computed tomography (DECT). In a phantom model, DECT post-processing was used to increase Gd attenuation using advanced monoenergetic extrapolation (MEI), to create virtual non-contrast images (Gd-VNC) and Gd maps and to quantify Gd content. Dilutions of Gd and iodinated CM (7-296 HU) were filled in syringes, placed in an attenuation phantom and scanned with standard DECT protocols (80 &100/Sn140 kV). MEI (40-190 keV) and VNC images as well as Gd maps were computed. The amount of Gd was quantified and the accuracy was compared to iodine images. Linear regression models were calculated to evaluate Gd attenuation of equivolume CM doses and clinical MRI doses. Applying monoenergetic reconstructions and using Gd as contrast agent (Gd MEI 40 keV) doubled Hounsfield-Units (HU) and 90% of the SNR (averaged: 225 HU, SNR3.1) are achievable, as compared to iodinated CM at 120 kV (averaged:110 HU, SNR3.5), at Gd doses of 1.0mmol/kg BW. The accuracies of Gd-VNC (deviation, 6±12 HU) images and Gd quantification (measurement error, 17%) were not significantly different to those of iodine enhanced images (VNC:deviation, 2±11 HU; measurement error,14%). Using monoenergetic extrapolation at 40keV, it is possible to increase Gd-CM attenuation significantly. Thus, equivalent HU and half the SNR in comparison to a standard dose of ICM at 120kV can be expected at a Gd-CM dose of 0.5mmol/kg BW. Post-processing features of iodine based DECT like monoenergetic or VNC images, iodine maps or quantification of CM are feasible with the use of Gd-CM. Copyright © 2017 Elsevier Inc. All rights reserved.

Accumulation rate in a tropical Andean glacier as a proxy for northern Amazon precipitation

Science.gov (United States)

da Rocha Ribeiro, Rafael; Simões, Jefferson Cardia; Ramirez, Edson; Taupin, Jean-Denis; Assayag, Elias; Dani, Norberto

2018-04-01

Andean tropical glaciers have shown a clear shrinkage throughout the last few decades. However, it is unclear how this general retreat is associated with variations in rainfall patterns in the Amazon basin. To investigate this question, we compared the annual net accumulation variations in the Bolivian Cordillera Real (Andes), which is derived from an ice core from the Nevado Illimani (16° 37' S, 67° 46' W), covering the period 1960-1999 using the Amazonian Rainfall Index, Northern Atlantic Index (TNA), Multivariate ENSO Index (MEI), and Pacific Decadal Oscillation (PDO). The accumulation rate at the Nevado Illimani ice core decreased by almost 25% after 1980, from 1.02 w.eq. a-1 (water equivalent per year) in the 1961-1981 period to 0.76 w.eq. a-1 in the 1981-1999 period. The Northern Amazonian Rainfall (NAR) index best reflects changes in accumulation rates in the Bolivian ice core. Our proposal is based on two observations: (1) This area shows reduced rainfall associated with a more frequent and intense El Niño (during the positive phase of the MEI). The opposite (more rain) is true during La Niña phases. (2) Comparisons of the ice core record and NAR, PDO, and MEI indexes showed similar trends for the early 1980s, represented by a decrease in the accumulation rates and its standard deviations, probably indicating the same causality. The general changes observed by early 1980s coincided with the beginning of a PDO warm phase. This was followed by an increase in the Amazonian and tropical Andean precipitation from 1999, coinciding with a new PDO phase. However, this increase did not result in an expansion of the Zongo Glacier area.

Radionuclide Air Emissions Report for the Hanford Site Calendar Year 1999

International Nuclear Information System (INIS)

ROKKAN, D.J.

2000-01-01

This report documents radionuclide air emissions from the US. Department of Energy (DOE) Hanford Site in 1999 and the resulting effective dose equivalent to the maximally exposed individual (MEI) member of the public. The report has been prepared in accordance with the Code of Federal Regulations (CFR). Title 40, Protection of the Environment, Part 61. National Emission Standards for Hazardous Air Pollutants, Subpart H, ''National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities'', and with the Washington Administrative Code (WAC) Chapter 246-247. Radiation Protection-Air Emissions. The federal regulations in Subpart H of 40 CFR 61 require the measurement and reporting of radionuclides emitted from US. Department of Energy (DOE) facilities and the resulting offsite dose from those emissions. A standard of 10 mrem/yr effective dose equivalent (EDE) is imposed on them. The EDE to the MEI due to routine emissions in 1999 from Hanford Site point sources was 0.029 mrem (2.9 E-04 mSv), which is less than 0.3 percent of the federal standard. WAC 246-247 requires the reporting of radionuclide emissions from all Hanford Site sources, during routine as well as nonroutine operations. The state has adopted the 40 CFR 61 standard of 10 mrem/yr EDE into their regulations. The state further requires that the EDE to the MEI be calculated not only from point source emissions but also from diffuse and fugitive sources of emissions. The EDE from diffuse and fugitive emissions at the Hanford Site in 1999 was 0.039 mrem (3.9 E-04 mSv) EDE. The total dose from point sources and from diffuse and fugitive sources of radionuclide emissions during all operating conditions in 1999 was 0.068 mrem (6.8 E-04 mSv) EDE, which is less than 0.7 percent of the state standard

Quantitative multiplex quantum dot in-situ hybridisation based gene expression profiling in tissue microarrays identifies prognostic genes in acute myeloid leukaemia

Energy Technology Data Exchange (ETDEWEB)

Tholouli, Eleni [Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL (United Kingdom); MacDermott, Sarah [The Medical School, The University of Manchester, Oxford Road, M13 9PT Manchester (United Kingdom); Hoyland, Judith [School of Biomedicine, Faculty of Medical and Human Sciences, The University of Manchester, Oxford Road, M13 9PT Manchester (United Kingdom); Yin, John Liu [Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL (United Kingdom); Byers, Richard, E-mail: richard.byers@cmft.nhs.uk [School of Cancer and Enabling Sciences, Faculty of Medical and Human Sciences, The University of Manchester, Stopford Building, Oxford Road, M13 9PT Manchester (United Kingdom)

2012-08-24

Highlights: Black-Right-Pointing-Pointer Development of a quantitative high throughput in situ expression profiling method. Black-Right-Pointing-Pointer Application to a tissue microarray of 242 AML bone marrow samples. Black-Right-Pointing-Pointer Identification of HOXA4, HOXA9, Meis1 and DNMT3A as prognostic markers in AML. -- Abstract: Measurement and validation of microarray gene signatures in routine clinical samples is problematic and a rate limiting step in translational research. In order to facilitate measurement of microarray identified gene signatures in routine clinical tissue a novel method combining quantum dot based oligonucleotide in situ hybridisation (QD-ISH) and post-hybridisation spectral image analysis was used for multiplex in-situ transcript detection in archival bone marrow trephine samples from patients with acute myeloid leukaemia (AML). Tissue-microarrays were prepared into which white cell pellets were spiked as a standard. Tissue microarrays were made using routinely processed bone marrow trephines from 242 patients with AML. QD-ISH was performed for six candidate prognostic genes using triplex QD-ISH for DNMT1, DNMT3A, DNMT3B, and for HOXA4, HOXA9, Meis1. Scrambled oligonucleotides were used to correct for background staining followed by normalisation of expression against the expression values for the white cell pellet standard. Survival analysis demonstrated that low expression of HOXA4 was associated with poorer overall survival (p = 0.009), whilst high expression of HOXA9 (p < 0.0001), Meis1 (p = 0.005) and DNMT3A (p = 0.04) were associated with early treatment failure. These results demonstrate application of a standardised, quantitative multiplex QD-ISH method for identification of prognostic markers in formalin-fixed paraffin-embedded clinical samples, facilitating measurement of gene expression signatures in routine clinical samples.

Influence of Ce 0.68 Zr 0.32 O 2 solid solution on depositing ...

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 29; Issue 1. Influence of Ce0.68Zr0.32O2 solid solution on depositing -alumina washcoat on FeCrAl foils. Mei-Qing Shen Li-Wei Jia Wen-Long Zhou Jun Wang Ying Huang. Composites Volume 29 Issue 1 February 2006 pp 73-76 ...

The Emergence of Autoclitic Frames in Atypically and Typically Developing Children as a Function of Multiple Exemplar Instruction

Science.gov (United States)

Luke, Nicole; Greer, R. Douglas; Singer-Dudek, Jessica; Keohane, Dolleen-Day

2011-01-01

In two experiments, we tested the effect of multiple exemplar instruction (MEI) for training sets on the emergence of autoclitic frames for spatial relations for novel tacts and mands. In Experiment 1, we used a replicated pre- and post-intervention probe design with four students with significant learning disabilities to test for acquisition of…

Browse Title Index

African Journals Online (AJOL)

Items 201 - 250 of 2037 ... Vol 14, No 11 (2015), Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii, Abstract PDF. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, Wei-wei Wang, Yuan-yuan Luo, Hou-zhao Wang.

n Perspektief op resente gebeure in die Nederduitsch Hervormde ...

African Journals Online (AJOL)

28 Mei 2014 ... Soortgelyke poging is 'n artikel wat in 2011 in Historia verskyn het, wat die resente geskiedenis van die Nederduitse Gereformeerde (NG) Kerk ten opsigte van die kerk se ...... en tydskrifte was vir lidmate deur die internet beskikbaar. Deur 'n knoppie op die rekenaar te druk, kon enigeen 'n standpunt stel ...

Pinoresinol diglucoside exhibits protective effect on dexamethasone ...

African Journals Online (AJOL)

Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 ... Zhan-Feng Zhang, Ji-Kang Min, Dan Wang, Jian-Ming Zhong* .... mineral density meter (Beijing Zhongxi Yuanda ..... Svedbom A, Ivergård M, Hernlund E, Rizzoli R, Kanis JA. ... Pan Y, Niu Y, Li C, Zhai Y, Zhang R, Guo X, Mei Q. Du-.

KI~I)ERS I~ ~ILITERE VERI3A~1)

African Journals Online (AJOL)

dat hy te oud vir trompetblaser geword het. Hy kwalifiseer as Gesondheidsinspekteur en attesteer op 2 Junie 1944 weer by die Suid-. Afrikaanse Weermag om as Vrywilliger in. Wereldoorlog 1/ diens te doen. Hy word op. 17 Mei 1946 met die rang van sersant gede- mobiliseer. Op 70-jarige leeftyd tree Fray as Hoofgesond-.

lidmate se houding teenoor kerkvereniging in die ngk- familie: 'n ...

African Journals Online (AJOL)

Liezel

9 Januarie, p. 7. 2005. NGK 'reeds aan't skeur'. VS-moderator reageer op berigte. 16 Mei, p. 1. WEITEN, W. 2002. Psychological themes and variations. 5th ed. California: Wadsworth Thomson. Learning. ZIMBARDO, P.G. & LEIPPE, M.R.. 1991. The psychology of attitude change and social influence. New York: McGraw-Hill ...

Korte mededelingen

NARCIS (Netherlands)

NN,

1962-01-01

Carex riparia Curt. x C. vesicaria L. (C. x csomadensis Simonk.). Deze bastaard, die tot nu toe hier te lande alleen bekend was van Neerbosch bij Nijmegen, werd op 16 mei 1961 aangetroffen aan een vennetje in het Liesbos bij Breda, door Chr. G. van Leeuwen (Bilthoven), H. N. Leys (Ede, Gld.) en I.

SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster.

Science.gov (United States)

Yan, Rihui; Thomas, Sharon E; Tsai, Jui-He; Yamada, Yukihiro; McKee, Bruce D

2010-02-08

Sister chromatid cohesion is essential to maintain stable connections between homologues and sister chromatids during meiosis and to establish correct centromere orientation patterns on the meiosis I and II spindles. However, the meiotic cohesion apparatus in Drosophila melanogaster remains largely uncharacterized. We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in Drosophila. In solo mutants, sister centromeres separate before prometaphase I, disrupting meiosis I centromere orientation and causing nondisjunction of both homologous and sister chromatids. Centromeric foci of the cohesin protein SMC1 are absent in solo mutants at all meiotic stages. SOLO and SMC1 colocalize to meiotic centromeres from early prophase I until anaphase II in wild-type males, but both proteins disappear prematurely at anaphase I in mutants for mei-S332, which encodes the Drosophila homologue of the cohesin protector protein shugoshin. The solo mutant phenotypes and the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis.

Strain relaxation of CdTe on Ge studied by medium energy ion scattering

Energy Technology Data Exchange (ETDEWEB)

Pillet, J.C., E-mail: jean-christophe.pillet@cea.fr [Univ. Grenoble Alpes, CEA, LETI, MINATEC campus, F38000 Grenoble (France); CEA, LETI, Département Optique et Photonique, F38054 Grenoble (France); Pierre, F. [Univ. Grenoble Alpes, CEA, LETI, MINATEC campus, F38000 Grenoble (France); CEA, LETI, Service de Caractérisation des Matériaux et Composants, F38054 Grenoble (France); Jalabert, D. [Univ. Grenoble Alpes, CEA, LETI, MINATEC campus, F38000 Grenoble (France); CEA-INAC/UJF-Grenoble 1 UMR-E, SP2M, LEMMA, Minatec Grenoble F-38054 (France)

2016-10-01

We have used the medium energy ion scattering (MEIS) technique to assess the strain relaxation in molecular-beam epitaxial (MBE) grown CdTe (2 1 1)/Ge (2 1 1) system. A previous X-ray diffraction study, on 10 samples of the same heterostructure having thicknesses ranging from 25 nm to 10 μm has allowed the measurement of the strain relaxation on a large scale. However, the X-ray diffraction measurements cannot achieve a stress measurement in close proximity to the CdTe/Ge interface at the nanometer scale. Due to the huge lattice misfit between the CdTe and Ge, a high degree of disorder is expected at the interface. The MEIS in channeling mode is a good alternative in order to profile defects with a high depth resolution. For a 21 nm thick CdTe layer, we observed, at the interface, a high density of Cd and/or Te atoms moved from their expected crystallographic positions followed by a rapid recombination of defects. Strain relaxation mechanisms in the vicinity of the interface are discussed.

Endoplasmic-reticulum-mediated microtubule alignment governs cytoplasmic streaming.

Science.gov (United States)

Kimura, Kenji; Mamane, Alexandre; Sasaki, Tohru; Sato, Kohta; Takagi, Jun; Niwayama, Ritsuya; Hufnagel, Lars; Shimamoto, Yuta; Joanny, Jean-François; Uchida, Seiichi; Kimura, Akatsuki

2017-04-01

Cytoplasmic streaming refers to a collective movement of cytoplasm observed in many cell types. The mechanism of meiotic cytoplasmic streaming (MeiCS) in Caenorhabditis elegans zygotes is puzzling as the direction of the flow is not predefined by cell polarity and occasionally reverses. Here, we demonstrate that the endoplasmic reticulum (ER) network structure is required for the collective flow. Using a combination of RNAi, microscopy and image processing of C. elegans zygotes, we devise a theoretical model, which reproduces and predicts the emergence and reversal of the flow. We propose a positive-feedback mechanism, where a local flow generated along a microtubule is transmitted to neighbouring regions through the ER. This, in turn, aligns microtubules over a broader area to self-organize the collective flow. The proposed model could be applicable to various cytoplasmic streaming phenomena in the absence of predefined polarity. The increased mobility of cortical granules by MeiCS correlates with the efficient exocytosis of the granules to protect the zygotes from osmotic and mechanical stresses.

Climate Variability and Phytoplankton in the Pacific Ocean

Science.gov (United States)

Rousseaux, Cecile

2012-01-01

The effect of climate variability on phytoplankton communities was assessed for the tropical and sub-tropical Pacific Ocean between 1998 and 2005 using an established biogeochemical assimilation model. The phytoplankton communities exhibited wide range of responses to climate variability, from radical shifts in the Equatorial Pacific, to changes of only a couple of phytoplankton groups in the North Central Pacific, to no significant changes in the South Pacific. In the Equatorial Pacific, climate variability dominated the variability of phytoplankton. Here, nitrate, chlorophyll and all but one of the 4 phytoplankton types (diatoms, cyanobacteria and coccolithophores) were strongly correlated (pphytoplankton groups (chlorophytes and coccolithophores). Ocean biology in the South Pacific was not significantly correlated with MEI. During La Nina events, diatoms increased and expanded westward along the cold tongue (correlation with MEI, r=-0.81), while cyanobacteria concentrations decreased significantly (r=0.78). El Nino produced the reverse pattern, with cyanobacteria populations increasing while diatoms plummeted. The diverse response of phytoplankton in the different major basins of the Pacific suggests the different roles climate variability can play in ocean biology.

Conversion of MyoD to a Neurogenic Factor: Binding Site Specificity Determines Lineage

Directory of Open Access Journals (Sweden)

Abraham P. Fong

2015-03-01

Full Text Available MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a “shared” E-box sequence (CAGCTG and a “private” sequence (CAGGTG or CAGATG, respectively. To determine whether private-site recognition is sufficient to confer lineage specification, we generated a MyoD mutant with the DNA-binding specificity of NeuroD2. This chimeric mutant gained binding to NeuroD2 private sites but maintained binding to a subset of MyoD-specific sites, activating part of both the muscle and neuronal programs. Sequence analysis revealed an enrichment for PBX/MEIS motifs at the subset of MyoD-specific sites bound by the chimera, and point mutations that prevent MyoD interaction with PBX/MEIS converted the chimera to a pure neurogenic factor. Therefore, redirecting MyoD binding from MyoD private sites to NeuroD2 private sites, despite preserved binding to the MyoD/NeuroD2 shared sites, is sufficient to change MyoD from a master regulator of myogenesis to a master regulator of neurogenesis.

Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells.

Science.gov (United States)

Uribe, Rosa A; Hong, Stephanie S; Bronner, Marianne E

2018-01-01

The enteric nervous system arises from neural crest cells that migrate as chains into and along the primitive gut, subsequently differentiating into enteric neurons and glia. Little is known about the mechanisms governing neural crest migration en route to and along the gut in vivo. Here, we report that Retinoic Acid (RA) temporally controls zebrafish enteric neural crest cell chain migration. In vivo imaging reveals that RA loss severely compromises the integrity and migration of the chain of neural crest cells during the window of time window when they are moving along the foregut. After loss of RA, enteric progenitors accumulate in the foregut and differentiate into enteric neurons, but subsequently undergo apoptosis resulting in a striking neuronal deficit. Moreover, ectopic expression of the transcription factor meis3 and/or the receptor ret, partially rescues enteric neuron colonization after RA attenuation. Collectively, our findings suggest that retinoic acid plays a critical temporal role in promoting enteric neural crest chain migration and neuronal survival upstream of Meis3 and RET in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

Onderzoekers foerageren ook

NARCIS (Netherlands)

Blacquiere, T.

2012-01-01

Het is mei. Tenzij het regent, zijn de bijen de hele lange dag aan het zoeken en binnenhalen van nectar, stuifmeel, propolis, water. Dat foerageren gebeurt om te voorzien in de behoeften van het hele bijenvolk op dít moment: als het heet is moet er meteen water worden gehaald om het volk te koelen.

Ninth Biennial Congress of the Association of Physicians

African Journals Online (AJOL)

4 Mei 1974 ... The 9th Biennial Congress of the Association of. Physicians of South Africa takes place on the campus of the University of Pretoria during the first week in July. There is every reason to expect that this will be a particularly interesting and im- portant congress and every effort is being made to ensure its ...

die ontstaan van vrouelugverenigings in suid-afrika voor die tweede

African Journals Online (AJOL)

aangestel. Ander eenhede het later gevolg. Drle van die Vrouehulplugmag se lelersflgure staan voor die VHLM se kleure wat gewy Is In Durban op 18 Mei 1940. Die vroue Is vlnr mal (meil E. Percival-Hart, It-kol (mev) D. Dunning en mal (mel) M. Egerton-Bird. 24. Scientia Militaria, South African Journal of Military Studies, ...

GODSBEELDE IN DIE LITURGIE

African Journals Online (AJOL)

15 Mei 2010 ... Biezeveld, de Boer, Brümmer, Muis. 2001; Brown 2006; Durand 2007). ... Wanneer sal hy weer in God se teenwoordigheid verskyn (vers 3)? Dié vraag is vol onsekerheid. (Schuman 2004:8). Sy onsekerheid ... God se volk en die enkeling in die geskiedenis het al die trou van God ervaar waarop die digter ...

Tako-tsubo cardiomyopathy after a quarrel.

African Journals Online (AJOL)

Tako-tsubo cardiomyopathy after a quarrel. Dong-Mei Jiang1,a, Ze-Wei Sunc2,a, Jie Han2. 1. Department of Cardiology, Biomedical research (therapy) center, Sir Run Run Shaw Hospital,. College of ... acterized by (1) sudden onset of chest pain or shortness of breath; (2) ... In the present report, we de- scribe a case of ...

THE COMMAND OF THE TREND: SOCIAL MEDIA AS A WEAPON IN THE INFORMATION AGE

Science.gov (United States)

2017-06-01

James. The Wisdom of Crowds. New York: Anchor Books, 2005. Sun - tzu , Ralph D. Sawyer, and Mei-chiin Lee. Sun Tzu : The Art of War. Boulder, CO...71 BIBLIOGRAPHY ...Trump’s presidency so far.” CNN.com, March 2, 2017. 78 Bibliography Alario, Celia. “Fake Followers and Twitter Astroturf: It’s Sorta Social

south african medical journal suid-afrikaansemediesetydskrif

African Journals Online (AJOL)

22 Mei 1971 ... Doef! Daf! Die tyd stap aan. Ons wil nie verskonings vind waarom die dokter se modus operandi in veranderde tye gewysig is nie, en wil ook nie te kenne gee dat die dokter willoos sit en toekyk het hoe omstandighede gekerf-kerf het aan sy beeld nie. Ons wil verder gaan-die intelligente dokter pas horn.

n by- kans tradisionele insinking gevolg. Daarna het

African Journals Online (AJOL)

Op 3 Julie 1942 het die DAF 770 krygsvlugte uitgevoer, waarvan 155 of rekening van no 3. (SA) Vleuel gekom het. Op 4 November 1942 het Rommel se terugtog begin: Eers van EI. Alamein na Agheila, daarna na Tripoli en ver- volgens na Tunisie en in Mei 1943 die ont- ruiming van Afrika. Sedert April 1941 het die SALM ...

Origen parental, estado de no disyunción y recombinación meiótica del cromosoma 21 extra en el síndrome de Down: estudio en una muestra de población colombiana Parental origin, nondisjunction, and recombination of the extra chromosome 21 in Down syndrome: a study in a sample of the Colombian population

Directory of Open Access Journals (Sweden)

Gonzalo Humberto Arboleda

2010-08-01

Full Text Available Introducción. La trisomía 21 libre es responsable del 95% de los casos de síndrome de Down. La edad materna y la recombinación son los principales factores de riesgo asociados con la concepción de estos individuos. El origen materno de la trisomía ocurre en el 90% de los casos, mientras que los casos de origen paterno y mitótico comparten un 10%. Por otra parte, la recombinación como factor de riesgo para la trisomía 21 no ha sido comprobada completamente.
Objetivo. Analizar y validar estas observaciones en una muestra colombiana de casos con trisomía 21 libre.
Materiales y métodos. Se estudiaron 22 afectados con síndrome de Down (trisomía libre y sus respectivos padres. Se usaron marcadores microsatélites de ADN para determinar el origen en los progenitores, el estado de no disyunción y los eventos de recombinación. Por medio de pruebas no paramétricas se compararon los resultados con los reportados en la literatura. Se realizó análisis de correspondencias múltiples para reconocer los diferentes grupos y sus asociaciones.
Resultados. La distribución de la trisomía 21 fue 90,9% materna, 4,5% paterna y 4,5% mitótica, similar a las reportadas previamente. Sin embargo, existen diferencias en la frecuencia de errores del estado meiótico para origen materno (46,1% meiosis I y 53,9% meiosis II comparada con la de los reportados previamente (70% meiosis I y 30% meiosis II. El análisis de correspondencias múltiples mostró asociación entre eventos de recombinación local y ausencia de recombinación con estados de no disyunción específicos.
Conclusiones. Las configuraciones quiasmáticas susceptibles están asociadas de manera específica a errores en la meiosis I y la meiosis II materna. Es necesario clasificar la frecuencia de no disyunción en estados meióticos maternos en nuestra población.
Introduction. Free trisomy 21 is responsible for 95% of Down syndrome cases. Advanced maternal age and

ESTIMASI KELIMPAHAN IKAN GABUS (Channa striata Bloch, 1793 DENGAN METODE HIDROAKUSTIK DI SUNGAI LEMPUING, SUMATERA SELATAN

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Zulkarnaen Fahmi

2016-03-01

Full Text Available Kegiatan pengkajian stok sumberdaya ikan yang dilakukan secara berkala bertujuan untuk optimasi pemanfaatan sumberdaya perikanan bagi kegiatan perikanan tangkap. Kegiatan pengkajian stok ikandengan survey akustik di perairan Lubuk Lampam telah dilakukan pada tahun 2011 sebanyak 2 (dua kali dengan interval waktu 3 (tiga bulan untuk melihat perubahan kelimpahan ikan gabus (Channa striatadi perairan tersebut. Ekstraksi data akustik meliputi data sebaran kelimpahan dan distribusi ukuran ikan dilakukan untuk melihat keragaman (variance nilai yang diperoleh. Hasil penelitian menunjukkan bahwa estimasi rata-rata kelimpahan ikan pada bulan Maret sebesar 7.53 ± 1.33 ekor/m2  lebih rendah dibandingkan pada bulan Mei sebesar 53.11 ± 9.43  ekor/m2  . Biomass ikan pada bulan Maret sebesar 75.59 ± 30.22 kg/ha lebih rendah dibandingkan pada bulan Mei sebesar 521 ± 65.01 kg/ha. Nilai rataan target strength ikan tunggal yang terdeteksi pada bulan Maret sebesar -54.81 ± 0.9 dB lebih rendah dibandingkan pada bulan Mei sebesar -50.03 ± 0.35 dB. Estimasi kelimpahan dan distribusi ikan di sungai Lempuing menunjukkan nilai keragaman (variance yang lebih rendah pada bulan Maret dibandingkan dengan bulan Mei 2011 untuk parameter kelimpahan dan biomass ikan, sedangkan untuk nilai rataan target strength ikan menunjukkan sebaliknya. Fish assessment using hydroacoustic in inland water was conducted to optimize fish exploitation activity. Successive hydroacoustic survey was conducted twice with interval three months in 2011 to estimated distribution fish abundance and size distribution of snakehead fish (Channa striata Bloch, 1793 in Lempuing River, South Sumatera. Reability test was conducted on hydroacoustic data including data distribution and abundance of fish size distribution to obtain edvariance value. The results showed that the average estimate abundance of fish on March about 7.53 ± 1.33 fish/m2 lower than in the month of May at 53.11 ± 9.43 fish/m2

Periostin overexpression is associated with worse prognosis in nasopharyngeal carcinoma from endemic area: a cohort study

Directory of Open Access Journals (Sweden)

Wei YC

2018-05-01

Full Text Available Yu-Ching Wei,1,2 Sheau-Fang Yang,2,3 Shih-Lun Chang,4,5 Tzu-Ju Chen,5,6 Sung-Wei Lee,7 Hung-Sung Chen,1 Li-Ching Lin,8 Chien-Feng Li6,9,10 1Department of Pathology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 2Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 4Department of Otolaryngology, Chi Mei Medical Center, Tainan, Taiwan; 5Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan; 6Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan; 7Department of Radiation Oncology, Chi Mei Medical Center, Liouying, Tainan, Taiwan; 8Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan; 9National Institute of Cancer Research, National Health Research Institute, Tainan, Taiwan; 10Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan Purpose: Nasopharyngeal carcinoma (NPC is a heterogeneous disease. We searched for genes that function in cell adhesion in GSE12452, a published transcriptomic database. We found that POSTN, which encodes periostin (POSTN, was significantly upregulated in NPC tumorigenesis. Herein, we sought to analyze the expression of POSTN and its prognostic significances in patients with NPC. Materials and methods: In this single-institution retrospective study, we determined and analyzed POSTN expression by immunohistochemistry and H-score method, respectively, in 124 patients with NPC. The results indicated that POSTN expression was correlated with the clinicopathologic features, disease-specific survival (DSS, distant metastasis-free survival (DMFS, and local recurrence-free survival (LRFS of NPC. We performed univariate and multivariate analyses to determinate the statistical significance. Results: High POSTN expression was significantly associated with lymph node metastasis

17. telekomunikacioni forum TELFOR 2009

Directory of Open Access Journals (Sweden)

Nebojša N. Gaćeša

2010-04-01

Full Text Available U Beogradu je 24, 25. i 26. novembra 2009. godine, u Sava centru, održan 17. telekomunikacioni forum TELFOR 2009, u organizaciji Društva za telekomunikacije – Beograd, „Telekom Srbija“ a. d., JP PTT saobraćaja „Srbija“, Elektrotehničkog fakulteta Univerziteta u Beogradu i IEEE Serbia & Montenegro ComSoc Chapter and Section. Telekomunikacioni forum TELFOR organizuje se sedamnaesti put kao domaći i regionalni godišnji skup stručnjaka koji rade u oblastima telekomunikacija i informacionih tehnologija. Učesnici su uglavnom telekomunikacioni inženjeri, ali i ekonomisti, pravnici, menadžeri, operatori i drugi. Na taj način TELFOR predstavlja forum u okviru kojeg se razmatraju sva relevantna pitanja telekomunikacija: tehnička, razvojna, regulatorna i ekonomska, pitanja proizvodnje opreme, usluga, servisa i funkcionisanja sistema.

Tulkošanas problēmas Antuāna de Sent-Ekziperī pasakā "Mazais princis"

OpenAIRE

Skromule, Ilze

2012-01-01

Tulkošana ir process, kurā darbojas divas valodas un kultūras, turklāt līdzās avota teksta autoram tajā iesaistīts vēl viens cilvēks – tulkotājs - ar savu valodas, kultūras un personisko pieredzi. Līdz ar to rodas šaubas par to, vai ir iespējams sniegt mērķa valodas lasītājiem nemainītu avota teksta informāciju. Lai izprastu iemeslus, kas šo procesu kavē, un meklētu iespējas šķēršļus mazināt, par pētījuma mērķi tiek izvirzīts veikt divu Antuāna de Sent-Ekziperī pasakas „Mazais princis” tulkoj...

Līvānu novada centrālās bibliotēkas vēsturiskā attīstība

OpenAIRE

Kokina, Sarmīte

2007-01-01

Publikāciju klāsts par Līvānu novada centrālās bibliotēkas vēsturi ir ierobežots. Tajās ietvertā informācijas ir fragmentāra. Informācija ir pieejama arī izkliedētajos un nepietiekami izpētītajos nepublicētajos materiālos, kuri atrodas gan Līvānos, gan arī Latvijas Valsts vēstures arhīvā. Informācija šim darbam tika iegūta arī no bijušo un tagadējo bibliotēkas darbinieku stāstījumiem. Kaut arī senākais ieraksts bibliotēkas inventāra grāmatā saglabājies no 1947. gada, ir zināms, ka jau pirm...

Application of calcifying bacteria for remediation of stones and cultural heritages

Directory of Open Access Journals (Sweden)

M. Sudhakara eReddy

2014-06-01

Full Text Available Since ages, architects and artists worldwide have focused on usage of durable stones as marble and limestone for construction of beautiful and magnificent historic monuments as European Cathedrals, Roman and Greek temples, Taj Mahal etc. But survival of these irreplaceable cultural and historical assets is in question these days due to their degradation and deterioration caused by number of biotic and abiotic factors. These causative agents have affected not only the aesthetic appearance of these structures, but also lead to deterioration of their strength and durability. The present review emphasizes about different causative agents leading to deterioration and application of microbially induced calcium carbonate precipitation as a novel and potential technology for dealing with these problems. The study also sheds light on benefits of microbial carbonate binders over the traditional agents and future directions.

Application of calcifying bacteria for remediation of stones and cultural heritages

Science.gov (United States)

Dhami, Navdeep Kaur; Reddy, M. Sudhakara; Mukherjee, Abhijit

2014-01-01

Since ages, architects and artists worldwide have focused on usage of durable stones as marble and limestone for construction of beautiful and magnificent historic monuments as European Cathedrals, Roman, and Greek temples, Taj Mahal etc. But survival of these irreplaceable cultural and historical assets is in question these days due to their degradation and deterioration caused by number of biotic and abiotic factors. These causative agents have affected not only the esthetic appearance of these structures, but also lead to deterioration of their strength and durability. The present review emphasizes about different causative agents leading to deterioration and application of microbially induced calcium carbonate precipitation as a novel and potential technology for dealing with these problems. The study also sheds light on benefits of microbial carbonate binders over the traditional agents and future directions. PMID:25018751

LTV1 raidījuma „Aizliegtais paņēmiens” ētiskie aspekti

OpenAIRE

Zeikate, Ieva

2015-01-01

Bakalaura darba tēma ir LTV1 Raidījuma „Aizliegtais paľēmiens” ētiskie aspekti. Darba mērķis ir izpētīt raidījuma saturu, noskaidrot, vai tajā tiek ievēroti ţurnālistikas ētikas principi un vērtības, noteikt raidījuma mērķus un izmantotos līdzekļus, kā arī to saskaľotību, veicot raidījuma izpēti aptuveni gada garumā. Teorija balstīta par televīziju, pētnieciskās ţurnālistikas teorētisko raksturojumu, ētiku un ţurnālistikas ētikas pamatprincipiem. Izvēlētās pētniecības metodes i...

Determinacy in Static Analysis of jQuery

DEFF Research Database (Denmark)

Andreasen, Esben; Møller, Anders

2014-01-01

Static analysis for JavaScript can potentially help programmers find errors early during development. Although much progress has been made on analysis techniques, a major obstacle is the prevalence of libraries, in particular jQuery, which apply programming patterns that have detrimental conseque......Static analysis for JavaScript can potentially help programmers find errors early during development. Although much progress has been made on analysis techniques, a major obstacle is the prevalence of libraries, in particular jQuery, which apply programming patterns that have detrimental...... present a static dataflow analysis for JavaScript that infers and exploits determinacy information on-the-fly, to enable analysis of some of the most complex parts of jQuery. The techniques are implemented in the TAJS analysis tool and evaluated on a collection of small programs that use jQuery. Our...

Investigations on the local structure and the spin-Hamiltonian ...

Indian Academy of Sciences (India)

2016-07-13

Jul 13, 2016 ... (2016) 87: 22 c Indian Academy of Sciences. DOI 10.1007/s12043-016-1234-6. Investigations on the local structure and the spin-Hamiltonian parameters for the tetragonal Cu. 2+ centre in ZnGeF6·6H2O crystal. LI CHAO-YING. ∗. , HUANG YING and ZHENG XUE MEI. School of Physics and Electronic ...

Browse Title Index

African Journals Online (AJOL)

Items 4251 - 4300 of 11090 ... Vol 9, No 4 (2010), Effects of mowing utilization on forage yield and quality in five oat varieties in alpine area of the eastern Qinghai-Tibetan Plateau, Abstract PDF. W Gao-Lin, W Mei-Ru, G Ting, H Tian-Ming, G Davidson. Vol 7, No 17 (2008), Effects of municipal sewage sludge doses on the yield, ...

From DNA binding to transcriptional activation: Is the TALE complete?

Science.gov (United States)

Bobola, Nicoletta

2017-09-04

How transcription factors (TFs) control enhancer and promoter functions to effect changes in gene expression is an important question. In this issue, Hau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701154) show that the TALE TF MEIS recruits the histone modifier PARP1/ARTD1 at promoters to decompact chromatin and activate transcription. © 2017 Bobola.

NESHAP Dose-Release Factor Isopleths for Five Source-to-Receptor Distances from the Center of Site and H-Area for all Compass Sectors at SRS using CAP88-PC Version 4.0

Energy Technology Data Exchange (ETDEWEB)

Trimor, P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2017-08-09

The Environmental Protection Agency (EPA) requires the use of the computer model CAP88-PC to estimate the total effective doses (TED) for demonstrating compliance with 40 CFR 61, Subpart H (EPA 2006), the National Emission Standards for Hazardous Air Pollutants (NESHAP) regulations. As such, CAP88 Version 4.0 was used to calculate the receptor dose due to routine atmospheric releases at the Savannah River Site (SRS). For estimation, NESHAP dose-release factors (DRFs) have been supplied to Environmental Compliance and Area Closure Projects (EC&ACP) for many years. DRFs represent the dose to a maximum receptor exposed to 1 Ci of a specified radionuclide being released into the atmosphere. They are periodically updated to include changes in the CAP88 version, input parameter values, site meteorology, and location of the maximally exposed individual (MEI). This report presents the DRFs of tritium oxide released at two onsite locations, center-of-site (COS) and H-Area, at 0 ft. elevation to maximally exposed individuals (MEIs) located 1000, 3000, 6000, 9000, and 12000 meters from the release areas for 16 compass sectors. The analysis makes use of area-specific meteorological data (Viner 2014).

MICROSPOROGÉNESIS DE TRES ESPECIES DEL SUBGÉNERO PASSIFLORA (PASSIFLORA, PASSIFLORACEAE DE PARAGUAY

Directory of Open Access Journals (Sweden)

Claudia Pereira Sühsner

2016-01-01

Full Text Available El presente trabajo tuvo por objeto caracterizar cariológicamente las especies del género Passiflora L., subgénero Passiflora, del Distrito Félix Pérez Cardozo, Guairá, Paraguay. Por primera vez, se da a conocer el número cromosómico en meiosis 2n = 9II para P. alata Curtis y P. caerulea L. También, se confirma el número cromosómico de 2n = 9II para P. edulis Sims. El comportamiento meiótico en todas las especies estudiadas fue normal, con segregación regular de los cromosomas. La asociación cromosómica frecuentemente encontrada en diacinesis y metafase I fue de bivalentes. Las pocas irregularidades meióticas observadas consistieron en cromosomas rezagados en anafase I y fases asincrónicas en meiosis II, sin embargo, la viabilidad de polen es alta, entre 78,83% y 98,6%. Los resultados confirman x = 9 como número básico para el subgénero Passiflora. Este estudio es una importante contribución al conocimiento sobre la citogenética de las especies de Passiflora subg Passiflora de Paraguay.

Radioactive air emissions notice of construction for deactivation of the PUREX storage tunnel number 2; FINAL

International Nuclear Information System (INIS)

JOHNSON, R.E.

1999-01-01

The Plutonium-Uranium Extraction (PUREX) Plant Storage Tunnel Number 2 (hereafter referred to as the PUREX Tunnel) was built in 1964. Since that time, the PUREX Tunnel has been used for storage of radioactive and mixed waste. In 1991, the PUREX Plant ceased operations and was transitioned to deactivation. The PUREX Tunnel continued to receive PUREX Plant waste material for storage during transition activities. Before 1995, a decision was made to store radioactive and mixed waste in the PUREX Tunnel generated from other onsite sources, on a case-by-case basis. This notice of construction (NOC) describes the activities associated with the reactivation of the PUREX Tunnel ventilation system and the transfer of up to 3.5 million curies (MCi) of radioactive waste to the PUREX Tunnel from any location on the Hanford Site. The unabated total effective dose equivalent (TEDE) estimated for the hypothetical offsite maximally exposed individual (MEI) is 5.6 E-2 millirem (mrem). The abated TEDE conservatively is estimated to account for 1.9 E-5 mrem to the MEI. The following text provides information requirements of Appendix A of Washington Administrative Code (WAC) 246-247 (requirements 1 through 18)

Radioactive Air Emissions Notice of Construction (NOC) for the 300 Area Process Sewer Cleanout

International Nuclear Information System (INIS)

MENARD, N.M.

2000-01-01

This document serves as a NOC pursuant to the requirements of Washington Administrative Code (WAC) 246-247-060, and as a request for approval to construct pursuant to 40 Code of Federal Regulations (CFR) 61.07, for the cleanout of sections of the 300 Area PS. Approval of the NOC will allow the pressure washing of certain pipe sections, the sump in the TEDF lift station, and the cleaning of PS 16 of the 300 Area PS that contains low levels of radioactivity. Section 15.0 of this NOC discusses the estimated total effective dose equivalent (TEDE) to the offsite maximally exposed individual (MEI) resulting from the unabated emissions from these cleaning activities. Using the currently approved unit dose conversion factors in HNF-3602, the estimated potential TEDE to the MEI resulting from the unabated, fugitive emissions from cleanout of the 300 Area PS is 4.70 E-05 millirem (mrem) per year. This dose was derived by conservatively estimating the doses from both the pressure washing and the use of the Guzzler(trademark) for removal of the liquid/soil mixture, as described in Section 5.0. and adding these doses together

The TALE face of Hox proteins in animal evolution.

Science.gov (United States)

Merabet, Samir; Galliot, Brigitte

2015-01-01

Hox genes are major regulators of embryonic development. One of their most conserved functions is to coordinate the formation of specific body structures along the anterior-posterior (AP) axis in Bilateria. This architectural role was at the basis of several morphological innovations across bilaterian evolution. In this review, we traced the origin of the Hox patterning system by considering the partnership with PBC and Meis proteins. PBC and Meis belong to the TALE-class of homeodomain-containing transcription factors and act as generic cofactors of Hox proteins for AP axis patterning in Bilateria. Recent data indicate that Hox proteins acquired the ability to interact with their TALE partners in the last common ancestor of Bilateria and Cnidaria. These interactions relied initially on a short peptide motif called hexapeptide (HX), which is present in Hox and non-Hox protein families. Remarkably, Hox proteins can also recruit the TALE cofactors by using specific PBC Interaction Motifs (SPIMs). We describe how a functional Hox/TALE patterning system emerged in eumetazoans through the acquisition of SPIMs. We anticipate that interaction flexibility could be found in other patterning systems, being at the heart of the astonishing morphological diversity observed in the animal kingdom.

Sequim Site Radionuclide Air Emissions Report for Calendar Year 2012

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F.; Barnett, J. Matthew; Gervais, Todd L.

2013-04-01

This report is prepared to document compliance with the Code of Federal Regulations (CFR), Title 40, Protection of the Environment, Part 61, National Emission Standards for Hazardous Air Pollutants (NESHAP), Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities and ashington Administrative Code (WAC) Chapter 246-247, Radiation Protection Air Emissions. This report meets the calendar year 2012 Sequim Site annual reporting requirement for its operations as a privately-owned facility as well as its federally-contracted status that began in October 2012. Compliance is indicated by comparing the estimated dose to the maximally exposed individual (MEI) with the 10 mrem/yr Environmental Protection Agency (EPA) standard. The MSL contains only sources classified as fugitive emissions. Despite the fact that the regulations are intended for application to point source emissions, fugitive emissions are included with regard to complying with the EPA standard. The dose to the Sequim Site MEI due to routine operations in 2012 was 9E-06 mrem (9E-08 mSv). No non-routine emissions occurred in 2012. The MSL is in compliance with the federal and state 10 mrem/yr standard.

Measurement of radon exhalation rates in some soil samples collected near the international monument Taj Mahal, Agra

International Nuclear Information System (INIS)

Sharma, Jyoti; Kumar, Rupesh; Indolia, R.S.; Swarup, R.; Mahur, A.K.; Singh, Hargyan; Sonkawade, R.G.

2011-01-01

Human beings are exposed to ionizing radiation from natural sources due to the occurrence of natural radioactive elements in solids, rocks, sand, soil etc. used as building construction materials and to the internal exposure from radioactive elements through good, water and air. Radon exhalation rate is of prime importance for the estimation of radiation risk from various materials. In the present study soil samples collected near the Tajmahal Agra. Sealed Can Technique was adopted for radon exhalation measurements. All the soil samples collected were grinded, dried and sieved through a 100 mesh sieve. Equal amount of each sieved (100μm grain size) sample (100 gm) was placed at the base of the Cans of 7.5 cm height and 7.0 cm diameter similar to those used in the calibration experiment (Singh et al., 1997). LR-115 type II plastic track detector (2 cm x 2 cm) was fixed on the top inside of the cylindrical Can. Radon exhalation rate varies from 529 mBqm -2 h -1 to 1254 mBqm -2 h -1 . The results will be presented. (author)

Keragaman dan Peran Biologi Arthrophoda pada Sawah Irigasi dan Tegalan

OpenAIRE

Suwarno, Suwarno

2016-01-01

Penelitian ini bertujuan untuk mengetahui keragaman arthropoda dan peran biologinya pada tanah sawah irigasi dan tegalan. Penelitian ini dilaksanakan di daerah persawahan di daerah Sragen pada bulan Maret – Mei 2016. Metode Penelitian dengan menggunakan pitfall trap atau perangkap jebakan yang diletakkan area persawahan dan tegalan. Teknik pengumpulan data dengan menggunakan purposive sampling. Sampel arthropoda yang diperoleh diidentifikasi dan dianalisis di Laboratorium pendidikan Biologi. ...

Perturbation to Unified Symmetry and Adiabatic Invariants for Relativistic Hamilton Systems

International Nuclear Information System (INIS)

Zhang Mingjiang; Fang Jianhui; Lu Kai; Pang Ting; Lin Peng

2009-01-01

Based on the concept of adiabatic invariant, the perturbation to unified symmetry and adiabatic invariants for relativistic Hamilton systems are studied. The definition of the perturbation to unified symmetry for the system is presented, and the criterion of the perturbation to unified symmetry is given. Meanwhile, the Noether adiabatic invariants, the generalized Hojman adiabatic invariants, and the Mei adiabatic invariants for the perturbed system are obtained. (general)

The relation between energy intake and chewing index of diets fed to nursing ewes

DEFF Research Database (Denmark)

Nielsen, Mette Vestergaard; Nadeau, E.; Markussen, Bo

2017-01-01

after lambing of 91 kg (SD = 9.7), and nursed an average of 2.2 lambs (SD = 0.37). The average daily MEI was 42.0 MJ (SD = 8.35). The NorFor CI (min/MJ ME) values of the diets was estimated from the content of neutral detergent fibre (NDF; g/kg DM), indigestible NDF (iNDF; g/kg NDF), and the theoretical...

Kasus Diabetes Mellitus Pada Kucing Lokal

OpenAIRE

Ayu Fitriani; I Nyoman Suartha; Sri Kayati Widyastuti

2016-01-01

Penelitian ini bertujuan mengamati gejala klinis, gambaran hematologi dan kimia klinis pada penderita DM. Penelitian dilaksanakan di Bali Veterinary Clinic Pererena Bali. Waktu penelitian berlangsung pada akhir bulan Maret sampai bulan Mei 2015. Kucing penderita DM memiliki gejala klinis polyuria, polydipsia, polyphagia, penurunan berat badan, luka basah yang tidak kunjung sembuh, gusi pucat kekuningan, peningkatan temperatur tubuh, anoreksia. Pada uji darah lengkap didapatkan hasil White Blo...

Pertumbuhan Dan Produktivitas Sawi Pak Choy (Brasica Rapa L.) Pada Umur Transplanting Dan Pemberian Mulsa Organik

OpenAIRE

Pribadi, Gandhi Yudhistira; Roviq, Mochammad; Wardiyati, Tatik

2014-01-01

Potensi produksi tanaman pak choy belum optimal, rendahnya produksi pak choy dikarenakan pada teknik budidayanya petani cendrung tidak memperhatikan kondisi lingkungan mikro dan masih belum adanya standart transplanting yang tepat. Penelitian bertujuan untuk mendapatkan teknik budidaya pak choy dengan penggunaan mulsa dan saat transplanting yang tepat. Dilaksanakan pada bulan Mei - Juli 2013 di Desa Pandanrejo, Kecamatan Bumiaji - Batu. Penelitian menggunakan Ranca-ngan Acak Kelompok Faktoria...

Sacensību trauksmes saistība ar sportisko sniegumu treniņos un sacensībās skeletonā un kamaniņu sportā

OpenAIRE

Lemberga, Krista

2017-01-01

Pētījuma mērķis bija izpētīt trauksmes pirms sacensībām saistību ar sniegumu tajās salīdzinājumā ar trauksmi pirms treniņiem un sniegumu tajos, noskaidrot, kāda ir sportistu trauksmes saistība ar sacensību pieredzi, kā arī izpētīt iespējamās atšķirības gan sportistu trauksmē pirms treniņiem un sacensībām, gan sportiskajā sniegumā treniņos un sacensībās. Sacensību trauksme tika mērīta retrospektīvi ar Pārskatītās Sacensību trauksmes kā stāvokļa aptauju – 2 (Revised Competitive State Anxiety In...

Uzņēmuma "ArtBag"stratēģija eksporta konkurētspējas paaugstināšanai

OpenAIRE

Lase-Lasmane, Zane

2012-01-01

Šī darba mērķis ir analizēt internetā bāzētu individualizētu rokassomiņu un apavu uzņēmumu stratēģijas un noskaidrot, vai tās izmanto kādu no ekonomiskajā literatūrā biežāk citētajām stratēģijām vai izvēlas vairāku stratēģiju sajaukumu. Darbā aplūkotas M. Portera Zemu izmaksu līderības, Diferenciācijas un Fokusa stratēģijas, kā arī V. Čana Kima un R. Mabornas Zilā okeāna stratēģija, definēts masveida individualizācijas fenomens. Pētnieciskajā daļā veikta divu nozares uzņēmumu – „Shoes of Prey...

"Coca─Cola" zīmola virzības stratēģijas un vēstījuma analīze

OpenAIRE

Cekuls, Oskars

2009-01-01

Darba virsraksts – "Coca─Cola" zīmola virzības stratēģijas un vēstījuma analīze. Darbs kopumā izklāstīts uz 88 lappusēm, tajā iekļauti 2 attēli, 1 tabula. Darbā izmantoti 46 literatūras avoti un pievienoti 7 pielikumi. Bakalaura darba mērķis izpētīt zīmola vispārējos aspektus, kā arī viena konkrēta uzņēmuma “Coca–Cola” virzības stratēģijas un pozicionēšanas pieredzi tirgū un uzņēmuma zīmola komunikāciju ar sabiedrību. Bakalaura darba struktūra sastāv no ievada, 6 nodaļām ar apakšn...

Attiecība starp varu un cilvēcību F. Kafkas „Metamorfoze”: interpretēta japāņu manga

OpenAIRE

Geplere, Jeļena

2016-01-01

Bakalaura darba tēma ir Franca Kafkas romānā „Metamorfoze” atrodamu varas attiecību interpretācija un analīze japāņu manga medijos, balstoties uz Bjorna Krausa un Edvarda Šila varas teorijām. Darbā tika izstrādāts salīdzinošais multimediju pētījums, kura mērķis ir pierādīt un aprakstīt attiecību starp cilvēcību un varu Kafkas darbā, kā arī identificēt kā šī attiecība tiek parādīta „Metamorfozes” ietekmētajās darbos.Pētījuma rezultāti rāda, ka „Metamorfozē” un analizētājās manga eksistē iekšēj...

Internetveikala E-diplomatic mārketinga stratēģija un attīstības prognozes.

OpenAIRE

Fedorčenko, Jeļena

2013-01-01

Darba mērķis ir izpētīt globālo Interneta tirdzniecības vidi, tās attīstības un beznodokļu tirdzniecības kā tirdzniecības specifiskā veida, attīstības iespējas Internetā; izvērtēt internetveikala E-diplomatic kopējo darbības stratēģiju un mērķus, izstrādāt atbilstošu mārketinga stratēģiju. Darbs sastāv no 3 pamatdaļām. Pirmā daļa ir darba teorētiskā bāze, tajā raksturota elektroniskās tirdzniecības mārketinga specifika un īpatnības. Otrā daļā tiek veikta pasaules elektroniskās tirdzniecīb...

Akcīzes nodokļa sociālekonomiskā loma Latvijā

OpenAIRE

Ēķe, Sintija

2009-01-01

Maģistra darba tēma : Akcīzes nodokļa sociālekonomiskā loma Latvijā. Maģistra darba mērķis ir analizēt akcīzes nodokļa lomu ekonomikā un budžeta ieņēmumos, analizēt tā politiku un izstrādāt priekšlikumus akcīzes nodokļa palielināšanai valsts budžetā. Darbs sastāv no ievada, trīs nodaļām, secinājumiem, priekšlikumiem un izmantotās literatūras saraksta. Maģistra darbs ir izstrādāts latviešu valodā un tajā ir 94 lapaspuses, kur ir iekļautas 22 tabulas un 52 attēli. Izmantotās literat...

Uzņēmējdarbības principu ieviešana publiskajā pārvaldē

OpenAIRE

Keiriša, Jolanta

2007-01-01

Maģistra darbs uzrakstīts latviešu valodā uz 79 lapām, satur 14 tabulas, 30 attēlus un 57 atsauces uz literatūras un informācijas avotiem. Maģistra darbs veltīts publiskās pārvaldes darbības efektivitātes uzlabošanai izmantojot uzņēmējdarbības principus. Šajā aspektā tika pētīts pašvaldību vadītāju pašnovērtējums par pārvaldes darbu. Pētījuma mērķis ir novērtēt situāciju Latvijas publiskajā pārvaldē, apskatīt kādi modernizācijas principi tajā darbojas, kādus vajadzētu vēl ieviest. Lai sasnieg...

Alkohols un biznesa lietišķā etiķete starp vīriešiem japāņu kompānijās

OpenAIRE

Stepčenko, Agnese

2011-01-01

Darbā tiek apskatīta alkohola nozīme un tā funkcijas japāņu biznesa lietišķās etiķetes ietvaros. Lai varētu izprast alkohola nozīmi mūsdienu japāņu biznesa vidē, alkohols tiek aplūkots Japānas ietvaros no vēsturiska skatpunkta, aplūkota kompānijas nozīme indivīda dzīvē un kulturālie uzvedības principi, kas ietekmē indivīda uzvedību, tajā skaitā arī kopīgos dzeršanas pasākumos. Turklāt tiek apskatīti alkoholisma apmēri un veidi kā valstī ar to cīnās, Japānas jaunāko paaudžu attieksmes un vērtī...

A putative mutant of a self-compatible yellow passion fruit with the corona color as a phenotypic marker Um provável mutante autocompatível de maracujazeiro amarelo com a cor da corona como marcador fenotípico

Directory of Open Access Journals (Sweden)

Margarete Magalhães Souza

2010-01-01

Full Text Available Yellow passion fruit (Passiflora edulis f. flavicarpa is a self-incompatible crop with purple corona flowers (PCF. Plants exhibiting white corona flowers (WCF were observed in an experimental field located in Campos dos Goytacazes - RJ, Brazil. This study was performed in order to test the fertility of these genotypes through studies of in vivo pollination, meiotic behavior and pollen viability. Using in vivo pollination, the mean fruit set percentage, obtained from self-pollinations at the moment that flowers open, was 70.83% in WCF and 0% in PCF. In terms of cytological analysis, for both kinds of plants, WCF and PCF, the meiotic behavior was considered regular, considering the high meiotic index estimated for both of them, 96.3% and 97.7%, and pollen viability, 98% and 99.5%, respectively. Such results suggest that the genotype WCF is self-compatible and interesting for use in genetic improvement of yellow passion fruit.O maracujazeiro amarelo (Passiflora edulis f. flavicarpa é autoincompatível e com flores de corona púrpura (PCF. Plantas com flores de corona branca (WCF foram observadas em um campo experimental localizado em Campos dos Goytacazes (RJ, Brasil. Este estudo foi realizado para testar a fertilidade dos genótipos WCF por meio de estudos de polinização in vivo, comportamento meiótico e viabilidade polínica. Utilizando polinização in vivo, o percentual médio de frutos obtidos das autopolinizações realizadas no momento de abertura da flor foi de 70,83% em WCF and 0% em PCF. Quanto às analises citológicas, para ambos os tipos de plantas, WCF e PCF, o comportamento meiótico foi considerado regular, com alto índice meiótico para ambas, 96,3% e 97,7%, e viabilidade polínica de 98% e 99,5% respectivamente. Tais resultados indicam que o genótipo WCF é autocompatível e de interesse para o uso em programas de melhoramento genético do maracujazeiro amarelo.

Radionuclide Air Emissions Report for the Hanford Site Calendar Year 1999

Energy Technology Data Exchange (ETDEWEB)

ROKKAN, D.J.

2000-06-01

This report documents radionuclide air emissions from the US. Department of Energy (DOE) Hanford Site in 1999 and the resulting effective dose equivalent to the maximally exposed individual (MEI) member of the public. The report has been prepared in accordance with the Code of Federal Regulations (CFR). Title 40, Protection of the Environment, Part 61. National Emission Standards for Hazardous Air Pollutants, Subpart H, ''National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities'', and with the Washington Administrative Code (WAC) Chapter 246-247. Radiation Protection-Air Emissions. The federal regulations in Subpart H of 40 CFR 61 require the measurement and reporting of radionuclides emitted from US. Department of Energy (DOE) facilities and the resulting offsite dose from those emissions. A standard of 10 mrem/yr effective dose equivalent (EDE) is imposed on them. The EDE to the MEI due to routine emissions in 1999 from Hanford Site point sources was 0.029 mrem (2.9 E-04 mSv), which is less than 0.3 percent of the federal standard. WAC 246-247 requires the reporting of radionuclide emissions from all Hanford Site sources, during routine as well as nonroutine operations. The state has adopted the 40 CFR 61 standard of 10 mrem/yr EDE into their regulations. The state further requires that the EDE to the MEI be calculated not only from point source emissions but also from diffuse and fugitive sources of emissions. The EDE from diffuse and fugitive emissions at the Hanford Site in 1999 was 0.039 mrem (3.9 E-04 mSv) EDE. The total dose from point sources and from diffuse and fugitive sources of radionuclide emissions during all operating conditions in 1999 was 0.068 mrem (6.8 E-04 mSv) EDE, which is less than 0.7 percent of the state standard.

Using the Small Ruminant Nutrition System to develop and evaluate an alternative approach to estimating the dry matter intake of goats when accounting for ruminal fiber stratification.

Science.gov (United States)

Regadas Filho, J G L; Tedeschi, L O; Cannas, A; Vieira, R A M; Rodrigues, M T

2014-11-01

The first objective of this research was to assess the ability of the Small Ruminant Nutrition System (SRNS) mechanistic model to predict metabolizable energy intake (MEI) and milk yield (MY) when using a heterogeneous fiber pool scenario (GnG1), compared with a traditional, homogeneous scenario (G1). The second objective was to evaluate an alternative approach to estimating the dry matter intake (DMI) of goats to be used in the SRNS model. The GnG1 scenario considers an age-dependent fractional transference rate for fiber particles from the first ruminal fiber pool (raft) to an escapable pool (λr), and that this second ruminal fiber pool (i.e., escapable pool) follows an age-independent fractional escape rate for fiber particles (ke). Scenario G1 adopted only a single fractional passage rate (kp). All parameters were estimated individually by using equations published in the literature, except for 2 passage rate equations in the G1 scenario: 1 developed with sheep data (G1-S) and another developed with goat data (G1-G). The alternative approach to estimating DMI was based on an optimization process using a series of dietary constraints. The DMI, MEI, and MY estimated for the GnG1 and G1 scenarios were compared with the results of an independent dataset (n=327) that contained information regarding DMI, MEI, MY, and milk and dietary compositions. The evaluation of the scenarios was performed using the coefficient of determination (R(2)) between the observed and predicted values, mean bias (MB), bias correction factor (Cb), and concordance correlation coefficient. The MEI estimated by the GnG1 scenario yielded precise and accurate values (R(2) = 082; MB = 0.21 Mcal/d; Cb = 0.98) similar to those of the G1-S (R(2) = 0.85; MB = 0.10 Mcal/d; Cb=0.99) and G1-G (R(2) = 0.84; MB = 0.18 Mcal/d; Cb = 0.98) scenarios. The results were also similar for the MY, but a substantial MB was found as follows: GnG1 (R(2) = 0.74; MB = 0.70 kg/d; Cb = 0.79), G1-S (R(2) = 0.71; MB = 0

Steel Sea-Going Ship Construction Standards (Kang-chih Hai-ch’uan Chien-tsao Kuei-fan).

Science.gov (United States)

1978-03-06

decozh lessthn5, ehto-aerolnabeth deck may be 2.-,;e he deo)th. (2) Flushing T.o.sts s.o Ad binocrae -’tth fdlowin re: (1)Mei*htfro td te~in: sot o...dieter d z , 4bD -53 m, it shou!d not be exceeding 1.5 :mm; -,,ihen chain diameter d,: 57 :-.n, it should not exceed 2 . Th. welded chains and links and

Air-Stable n-type Conductors and Semiconductors

Science.gov (United States)

2015-07-14

conjugated polymers using polystyrene for high-performance bulk heterojunction solar cells,” Chem. Mater., vol. 25, no. 24, pp. 4874–4880, 2013. J. Mei...the unique features of hydrogen-bonded polymer and graphene oxide (GO) as a macro-crosslinker. Importantly, it also possesses mechanical strength...polymer chains provide self-healing capability. GO is the oxidized form of graphene and has been established for its high-mechanical strength

PESAN MORAL DALAM FILM TO KILL A MOCKINGBIRD (ANALISIS SEMIOTIKA PADA FILM TO KILL A MOCKINGBIRD

OpenAIRE

RENYOET, JAQUILINE MELISSA

2014-01-01

2014 JAQUILINE MELISSA RENYOET. Pesan Moral Dalam Film To Kill A Mockingbird (Analisis Semiotika Pada Film To Kill A Mockingbird). (Dibimbing oleh Muh. Nadjib dan Alem Febri Sonni). Tujuan Penelitian ini adalah mengidentifikasi bentuk pesan moral dan memahami makna pesan moral dalam film To Kill A Mockingbird. Penelitian ini dilakukan selama kurang lebih 2 bulan yaitu Maret ??? Mei 2014. Metode yang digunakan untuk penelitian ini adalah metode penelitian kualitatif den...

Analisis Pemasaran Ayam Ras Pedaging di Pasar Tradisional Kota Medan

OpenAIRE

Fachri, Yusrizal

2017-01-01

130306044 YUSRIZAL FACHRI, 2017. “Analisis Pemasaran Ayam Ras Pedaging di Pasar Tradisional Kota Medan”. Dibimbing oleh ARMYN HAKIM DAULAY dan NEVY DIANA HANAFI. Penelitian ini bertujuan untuk mengidentifikasi karakteristik lembaga pemasaran, bentuk saluran, fungsi pemasaran, dan menganalisis nilai tambah di lembaga-lembaga pemasaran ayam ras pedaging di pasar tradisional Kota Medan pada April sampai Mei 2017. Penelitian ini menggunakan data primer yang didapatkan dari observasi dan waw...

Finding Effective Responses Against Cyber Attacks for Divided Nations

Science.gov (United States)

2015-12-01

Coordination Center LTE Long Term Evolution MAC Media Access Control MCRC Master Control and Reporting Center MEI Ministry of Electronics...satellites that aid Internet connections. Individual users can access the Internet via not only a wired connection up to 1 Gbps, but also by 4G LTE ...operate air-gapped intranets with security measures such as cryptographic modules that correspond to security levels. The MND does maintain the public

Mutation induction in repair-deficient strains of Drosophila

International Nuclear Information System (INIS)

Wuergler, F.E.; Graf, U.

1980-01-01

Experimental evidence indicates a polygenic control of mutagenesis in Drosophila melanogaster. In oocytes chromosome aberrations detected as half-translocations or dominant lethals depend on a repair system which in a number of genetically nonrelated strains shows different repair capacities. Sister chromatid exchanges are easily studied as ring chromosome losses. They develop through a genotype controlled mechanism from, premutational lesions. Stocks with particular pairs of third chromosomes were discovered in which increased sensitivity of larvae to the toxic effects of a monofunctional alkylating agent correlates with high frequencies of x-ray induced SCE's. Sex-linked mutagen-sensitive mutants could be shown to control mutation fixation: pronounced maternal effects were found when sperm carrying particular types of premutational lesions were introduced into different types of mutant oocytes. The mutant mus(1)101D1 was found to be unable to process lesions induced by the crosslinking agent nitrogen mustard into point mutations. Alkylation damage leads to increased point mutation frequencies in the excision repair deficient mutant mei-9L1, but to reduced frequencies in the post-replication repair deficient mutant mei-41D5. It became clear that the study of maternal effects on mutagenized sperm represents an efficient tool to analyze the gentic control of mutagenesis in the eukaryotic genome of Drosophila melanogaster

Radionuclide Air Emissions Report for 2012

Energy Technology Data Exchange (ETDEWEB)

Wahl, Linnea [Ernest Orlando Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

2013-05-01

Berkeley Lab operates facilities where radionuclides are produced, handled, store d, and potentially emitted . These facilities are subject to the EPA radioactive air emission regulations in 40 CFR 61, Subpart H (EPA 1989a). Radionuclides may be emitted from stacks or vents on buildings where radionuclide production or use is authorized or they may be emitted as diffuse sources. In 2012, all Berkeley Lab sources were minor sources of radionuclides (sources resulting in a potential dose of less than 0.1 mrem/yr [0.001 mSv/yr]) . These minor sources include d about 140 stack sources and no diffuse sources . T here were no unplanned airborne radionuclide emissions from Berkeley Lab operations . Emissions from minor sources were measured by sampling or monitoring or were calculated based on quantities used, received for use, or produced during the year. Using measured and calculated emissions, and building- specific and common parameters, Laboratory personnel applied the EPA -approved computer code s, CAP88-PC and COMPLY , to calculate doses to the maximally exposed individual (MEI) at any offsite point where there is a residence, school, business, or office. Because radionuclides are used at three noncontiguous locations (the main site, Berkeley West Bio center, and Joint BioEnergy Institute), three different MEIs were identified.

Activity of genes with functions in human Williams-Beuren Syndrome are impacted by mobile element insertions in the gray wolf genome.

Science.gov (United States)

vonHoldt, Bridgett M; Ji, Sarah S; Aardema, Matthew L; Stahler, Daniel; Udell, Monique A R; Sinsheimer, Janet S

2018-06-01

In canines, transposon dynamics have been associated with a hyper-social behavioral syndrome, although the functional mechanism has yet to be described. We investigate the epigenetic and transcriptional consequences of these behavior-associated mobile element insertions in dogs and Yellowstone wolves. We posit that the transposons themselves may not be the causative feature; rather, their transcriptional regulation may exert the functional impact. We survey four outlier transposons associated with hyper-sociability, with the expectation that they are targeted for epigenetic silencing. We predict hyper-methylation of mobile element insertions (MEIs), suggestive that the epigenetic silencing of and not the MEIs themselves may be driving dysregulation of nearby genes. We found that transposon-derived sequences are significantly hyper-methylated, regardless of their copy number or species. Further, we have assessed transcriptome sequence data and found evidence that mobile element insertions impact the expression levels of six genes (WBSCR17, LIMK1, GTF2I, WBSCR27, BAZ1B, and BCL7B), all of which have known roles in human Williams-Beuren syndrome due to changes in copy number, typically hemizygosity. Although further evidence is needed, our results suggest that a few insertions alter local expression at multiple genes, likely through a cis-regulatory mechanism that excludes proximal methylation.

Decreased stage migration rate of early gastric cancer with a new reconstruction algorithm using dual-energy CT images: a preliminary study

Energy Technology Data Exchange (ETDEWEB)

Shi, Cen [Shanghai Jiao Tong University School of Medicine, Department of Radiology, Ruijin Hospital, Shanghai (China); First Affiliated Hospital of Soochow University, Department of Radiology, Suzhou (China); Zhang, Huan; Du, Lianjun; Pan, Zilai; Yan, Fuhua [Shanghai Jiao Tong University School of Medicine, Department of Radiology, Ruijin Hospital, Shanghai (China); Yan, Jing [Siemens Medical System, Shanghai (China); Wang, Baisong [Shanghai Jiao Tong University School of Medicine, Department of Biological Statistics, Shanghai (China)

2017-02-15

To evaluate the potential value of advanced monoenergetic images (AMEIs) on early gastric cancer (EGC) using dual-energy CT (DECT). 31 EGC patients (19 men, 12 women; age range, 38-81 years; mean age, 57.19 years) were retrospectively enrolled in this study. Conventionally reconstructed polyenergetic images (PEIs) at 120 kV and virtual monoenergetic images (MEIs) and AMEIs at six different kiloelectron volt (keV) levels (from 40 to 90 keV) were evaluated from the 100 and Sn 140 kV dual energy image data, respectively. The visibility and stage migration of EGC for all three image data sets were evaluated and statistically analyzed. The objective and subjective image qualities were also evaluated. AMEIs at 40 keV showed the best visibility (80.7 %) and the lowest stage migration (35.5 %) for EGC. The stage migration for AMEIs at 40 keV was significantly lower than that for PEIs (p = 0.026). AMEIs at 40 keV had statistically higher CNR in the arterial and portal phases, gastric-specific diagnostic performance and visual sharpness compared with other AMEIs, MEIs and PEIs (all p < 0.05). AMEIs at 40 keV with MPR increase the CNR of EGC and thus potentially lower the stage migration of EGC. (orig.)

Input comparison of radiogenic neutron estimates for ultra-low background experiments

Science.gov (United States)

Cooley, J.; Palladino, K. J.; Qiu, H.; Selvi, M.; Scorza, S.; Zhang, C.

2018-04-01

Ultra-low-background experiments address some of the most important open questions in particle physics, cosmology and astrophysics: the nature of dark matter, whether the neutrino is its own antiparticle, and does the proton decay. These rare event searches require well-understood and minimized backgrounds. Simulations are used to understand backgrounds caused by naturally occurring radioactivity in the rock and in every piece of shielding and detector material used in these experiments. Most important are processes like spontaneous fission and (α,n) reactions in material close to the detectors that can produce neutrons. A comparison study of the (α,n) reactions between two dedicated software packages is detailed. The cross section libraries, neutron yields, and spectra from the Mei-Zhang-Hime and the SOURCES-4A codes are presented. The resultant yields and spectra are used as inputs to direct dark matter detector toy models in GEANT4, to study the impact of their differences on background estimates and fits. Although differences in neutron yield calculations up to 50% were seen, there was no systematic difference between the Mei-Hime-Zhang and SOURCES-4A results. Neutron propagation simulations smooth differences in spectral shape and yield, and both tools were found to meet the broad requirements of the low-background community.

Geografski aspekti ekološkog uzgoja ljekovitog bilja u Hrvatskoj

Directory of Open Access Journals (Sweden)

Željka Šiljković

2005-01-01

Full Text Available U Hrvatskoj se prikuplja i uzgaja između 160 i 170 autohtonih, ljekovitih i aromatičnih biljnih vrsta. Prirodno geografski uvjeti, posebice klimatski, pedološki i hidrografski, iznimno su povoljni za ekološki uzgoj ljekovitog bilja u svim dijelovima Republike Hrvatske. U radu je posebno opisan uzgoj kamilice (Matricaria chamomilae i lavande (Lavandula anustifolia kao dviju biljaka koje su do prije Domovinskog rata činile najveći udio uzgoja ljekovitog bilja u Hrvatskoj koja je bila jedna od vodećih svjetskih proizvođača kamilice i lavande. U članku je analizirano trenutno stanje uzgoja ljekovitog bilja u Hrvatskoj te mogućnosti koje nudi taj dosad neiskorišten gospodarski sektor. Glavni je cilj istaknuti prirodno-geografske uvjete koji utječu na ekološku proizvodnju ljekovitog bilja koja, ukoliko se provede sustavno, može pridonijeti revitalizaciji ruralnih prostora te usporiti procese deagrarizacije i deruralizacije.

Vadīšanas funkciju izpildes analīze Viļakas novada pašvaldībā.

OpenAIRE

Cibule, Rūta

2016-01-01

Bakalaura darba tēma ir “Vadīšanas funkciju izpildes analīze Viļakas novada pašvaldībā”. Darbā ir apskatītas vadīšanas funkcijas – organizēšana, plānošana, motivēšana, koordinēšana un kontrole, fokusējoties uz pirmajām trim minētajām. Bakalaura darba mērķis ir izanalizēt vadīšanas funkciju izpildi Viļakas novada domes administrācijā, pievēršot pastiprinātu uzmanību organizēšanai, motivēšanai un plānošanai. Lai šo mērķi izpildītu, pirmajā daļā autore izpētīja dažādus teorijas avotus, otrajā da...

Grafiskā stāstījuma uzbūve un trauma Hāleda Hoseinī grafiskajā romānā “Pūķa ķērājs”

OpenAIRE

Vanaga, Alīna

2016-01-01

Hāleda Hoseinī grafiskais romāns “Pūķa ķērājs”demonstrē grafisko romānu spēju vienlaicīgi uzrunāt lielu cilvēku daudzumu un tajā pašā laikā izteikt neaprakstāmo, kas apliecina to, ka grafiskie romāni ļoti labi prot darīt saprotamas tādas neaprakstāmas tēmas, kā trauma. Tādēļ, šī maģistra darba mērķis ir noteikt, kā grafiskā stāstījuma uzbūve attēlo traumu Hāleda Hoseinī grafiskajā romāna “Pūķa ķērājs” un kādu rezultātu tas rada. Iepriekš minētā mērķa sasniegšanai tika izvēlētas divas pētīšana...

Īpašuma teorija Dž. Loka un R. Nozika filozofijā

OpenAIRE

Melle, Diāna

2013-01-01

Šis bakalaura darbs ir pētījums par to, kā tiek skaidrota īpašuma teorija klasiskajā liberālismā un uz tā bāzes atvedinātajā libertārismā. Darba gaitā tiek aplūkota īpašuma teorija politiskās filozofijas izpratnē, tuvāk pievēršoties īpašuma izpratnei klasiskā liberālisma pārstāvja Džona Loka un libertārisma pārstāvja Roberta Nozika filozofijā. Tā mērķis ir izpētīt Loka un Nozika īpašuma izpratni, to kopējās un atšķirīgās iezīmes. Darbs parāda, kādi ir klasiskā liberālisma un libertārisma kopī...

Raseljavanje kao logistička operacija / Dislocation as logistic operation

Directory of Open Access Journals (Sweden)

Boban Milošević

2004-05-01

Full Text Available U ovom radu obrađuje se problem raseljavanja materijalnih sredstava i njihov razmeštaj na lokacijama, kao i mogućnost funkcionisanja elemenata sistema logističke podrške. U radu se određuje pojam raseljavanja. Opisan je način organizacije i tehnologije raseljavanja, gde se javlja potreba za optimizacijom različitih tereta i transportnih sredstava, kao i planiranje raseljavanja. Za tehnološke zahteve, koji se javljaju pri raseljavanju prikazan je način dimenzionisanja tehnoloških elemenata koji zadovoljavaju te zahteve. / Dislocation of material supplies (MS has been discussed as well as the functioning of logistic support system elements at different locations. After the definition, organization and technology of MS dislocation, the paper gives its planning and cases where optimization of different loads and transportation means is required. The method of dimensioning technological elements meeting the technological requirements during dislocation has been presented as well.

Calendula officinalis L. saturošo produktu bioloģiskās aktivitātes izvērtējums

OpenAIRE

Zepa, Līva

2016-01-01

Ārstniecības kliņģerītes ir vienas no senākajiem un pazīstamākajiem ārstniecības augiem pasaulē. Tās ir ātraudzīgas un jau vēsturiski plaši izmantotas tautas medicīnā. Pētījumi par ārstniecības kliņģerīšu lomu veselības saglabāšanā un stiprināšanā, izvērtējot aktīvo vielu saturu un sastāvu tajās, tās var pozitīvi ietekmēt cilvēka organismu gan profilakses nolūkos, gan kā papildus terapija ārstēšanas brīdī. Maģistra darba mērķis bija noskaidrot, kādas un cik daudz aktīvās vielas atrodamas pašg...

Veikala „Dīvāni un Dīvāni” reklāmas analīze un pilnveidošanas iespējas.

OpenAIRE

Alsiņa, Madara

2013-01-01

Bakalaura darba tēma „Veikala „Dīvāni un Dīvāni” reklāmas analīze un pilnveidošanas iespējas”. Bakalaura darba mērķis ir, pamatojoties uz teorijā gūtajām atziņām par reklāmu, izanalizēt veikala „Dīvāni un Dīvāni” reklāmas pasākumus, to stiprās un vājās puses, novērtēt reklāmas komunikatīvo efektivitāti, kā arī izstrādāt priekšlikumus veikala „Dīvāni un Dīvāni” reklāmas pilnveidošanai. Pirmajā darba daļā tiek apskatīti reklāmas kā mārketinga komunikāciju elementa teorētiskie aspekti – ...

“Tuvu attiecību” definēšanas principi geju un lesbiešu skatījumā

OpenAIRE

Rudzīte, Katrīna

2017-01-01

Bakalaura darbā “”Tuvu attiecību” definēšanas principi geju un lesbiešu skatījumā” pētītas radniecīgu vai radniecībai ļoti līdzīgu attiecību definēšanas un veidošanas prakses geju un lesbiešu vidū, pievēršot uzmanību tam, kādas nozīmes tuvībai un tuvām attiecībām tiek piešķirtas. Tuvība un tuvas attiecības, kas sadzīves realitātē bieži tiek skatītas kā pašsaprotamas parādības, kas pastāv personas privātajā telpā un neprasa plašāku refleksiju kultūrsociālā kontekstā, pētījumā tiek aplūkotas kā...

Iminium Salts by Meerwein Alkylation of Ehrlich’s Aldehyde

Directory of Open Access Journals (Sweden)

Gerhard Laus

2013-03-01

Full Text Available 4-(Dimethylaminobenzaldehyde is alkylated at the N atom by dialkyl sulfates, MeI, or Me3O BF4. In contrast, ethylation by Et3O BF4 occurs selectively at the O atom yielding a quinoid iminium ion. 4-(Diethylaminobenzaldehyde is alkylated only at O by either Et or Me oxonium reagent. The iminium salts are prone to hydrolysis giving the corresponding hydrotetrafluoroborates. Five crystal structures were determined.

Potential radiation doses from 1994 Hanford Operations

Energy Technology Data Exchange (ETDEWEB)

Soldat, J.K.; Antonio, E.J.

1995-06-01

This section of the 1994 Hanford Site Environmental Report summarizes the potential radiation doses to the public from releases originating at the Hanford Site. Members of the public are potentially exposed to low-levels of radiation from these effluents through a variety of pathways. The potential radiation doses to the public were calculated for the hypothetical MEI and for the general public residing within 80 km (50 mi) of the Hanford Site.

Mathematical Progress in Expressive Image Synthesis II

CERN Document Server

Anjyo, Ken

2015-01-01

The material included in this book provides selected presentations given at the international symposium MEIS2014. The book aims to provide a unique venue where various issues in computer graphics (CG) application fields are discussed by mathematicians as well as CG researchers and practitioners. The target audience is not limited to researchers in academia but also those in industries with a strong interest in digital media creation, scientific visualization, and visual engineering. .

GAMBARAN JENIS DAN JUMLAH KONSUMSI FAST FOOD DAN SOFT DRINK PADA MAHASISWA OBESITAS DI UNIVERSITAS HASANUDDIN

OpenAIRE

Suryanti, Rut; Jafar, Nurhaedar; Syam, Aminuddin

2013-01-01

Konsumsi fast food dan soft drink dapat menyebabkan kelebihan berat badan dan obesitas.Penelitian ini bertujuan untuk mengetahui gambaran jenis dan jumlah zat gizi makro dari konsumsi fast food dan soft drink pada mahasiswa yang obesitas.Jenis penelitian adalah deskriptif, dilaksanakan pada bulan Mei-Juni 2013 di Universitas Hasanuddin dengan jumlah responden 60 orang. Instrument penelitian adalah kuesioner identitas diri dan food frekuensiSemiQuantitatif fast food dan soft drink, food pictur...

OVERVIEW KEPUASAN PELANGGAN: STUDI KASUS PELAYANAN RIJSTAFFEL DI RESTORAN OASIS

OpenAIRE

Maria Pia Adiati; Agung Gita Subakti

2015-01-01

Rijstaffel service is not common found in fine dining restaurant in Indonesia. Oasis Restaurant in Jalan Raden Saleh, Jakarta, is a restaurant that is consistent in serving rijstaffel menu. The objective of this research is to analyze the level of consumer satisfaction and service quality in rijstaffel service at Oasis Restaurant. Research used qualitative method with library research by analyzing the questionnaire distributed by Oasis on Mei 2013 with 21 respondents. The result i...

ANALISIS PENYEBAB BANJIR KALI JUANA

OpenAIRE

Teguh Marhendi; Prapdita Nandhi Wardhana; Sigit Nurhadi; Isidorus Bramanti AP

2017-01-01

Kali Juana yang berada di Kabupaten Pati dan Kudus serta sebagian kecil di Kabupaten Grobogan dan Blora, merupakan kawasan banjir. Kejadian banjir di Kali Juana, sudah menjadi rutinitas setiap musim hujan.Dari Januari sampai bulan Mei 2016tercatat terjadi 11 kejadian banjir dibeberapa wilayah, seperti Kecamatan Kaliwungu, Undaan dan Mejobo (Kab. Kudus) serta Pati, Margorejo dan Juwana (Kab. Pati). Kali Juana merupakan bifurkasi Kali Serang pada Pintu Wilalung, yang berfungsi sebagai pintu ...

Diversity and Abundance of Insects as Bioindicators of the Environmental Impacts of Tin Mining in Bangka Island, Indonesia

OpenAIRE

Sulaiman, Norela; Sary, Nila; Abdullah, Maimon

2012-01-01

Satu kajian telah dijalankan untuk menentukan efek aktivitas pertambangan timah pada kelimpahan dan keragaman serangga dan memilih/menyaring kelompok taksonomi potensial sebagai kandidat potensial bagi bioindikator lingkungan yang baik. Pengambilan contoh dilakukan pada 28 Meiâˆ'12 Juni 2008 pada empat stasiun. Dua stasiun ditempatkan dalam daerah pertambangan (stasiun B1 dan B2) sementara dua stasiun control ditempatkan di sekitar daerah hutan lindung (stasiun B3 dan B4). Pengambilan contoh ...

Potensi Pemberian Ekstrak Daun Sirih (Piper Betle L) sebagai Pengawet Alami Ikan Selar (Selaroides Leptolepis)

OpenAIRE

Mentari, Nona Lia

2016-01-01

Telah dilakukan penelitian “Potensi Ekstrak Daun Sirih (Piper betle) sebagai Pengawet Alami Ikan Selar (Selaroides leptolepis)” di Kecamatan Syiah Kuala sejak bulan September 2015 sampai Mei 2016. Penelitian ini bertujuan untuk mengetahui pengaruh daun sirih terhadap pengawetan ikan selar, rasa, warna, tekstur dan bau. Desain penelitian ini adalah eksperimental dengan 7 perlakuan dan 3 kali ulangan. Konsentrasi ekstrak daun sirih divariasi mulai dari 10% ekstrak daun sirih (S10), 20% ekstrak ...

Entrepreneurial marketing in the digital age: A study of the SME tourism industry

OpenAIRE

Jones, R.; Alford, Philip; Wolfenden, Sally

2015-01-01

This paper contributes to developing research enquiry relating to research at the Marketing and Entrepreneurship Interface (MEI) from the small and medium-sized firm (SME) marketing perspective. The paper presents findings emanating from a digital destinations project based on the south coast of England and a new, ongoing project on implementing digital marketing strategies in the context of small owner-managed firms. This area of research advances knowledge in several areas and is significan...

Potential radiation doses from 1994 Hanford Operations

International Nuclear Information System (INIS)

Soldat, J.K.; Antonio, E.J.

1995-01-01

This section of the 1994 Hanford Site Environmental Report summarizes the potential radiation doses to the public from releases originating at the Hanford Site. Members of the public are potentially exposed to low-levels of radiation from these effluents through a variety of pathways. The potential radiation doses to the public were calculated for the hypothetical MEI and for the general public residing within 80 km (50 mi) of the Hanford Site

AIR AND RADON PATHWAY MODELING FOR THE F-AREA TANK FARM

International Nuclear Information System (INIS)

Dixon, K; Mark Phifer, M

2007-01-01

The F-Area Tank Farm (FTF) is located within F-Area in the General Separations Area (GSA) of the Savannah River Site (SRS) as seen in Figure 1. The GSA contains the F and H Area Separations Facilities, the S-Area Defense Waste Processing Facility, the Z-Area Saltstone Facility, and the E-Area Low-Level Waste Disposal Facilities. The FTF is a nearly rectangular shaped area and comprises approximately 20 acres, which is bounded by SRS coordinates N 76,604.5 to N 77,560.0 and E 52,435.0 to E 53,369.0. SRS is in the process of preparing a Performance Assessment (PA) to support FTF closure. As part of the PA process, an analysis was conducted to evaluate the potential magnitude of gaseous release of radionuclides from the FTF over the 100-year institutional control period and 10,000-year post-closure compliance period. Specifically, an air and radon pathways analysis has been conducted to estimate the flux of volatile radionuclides and radon at the ground surface due to residual waste remaining in the tanks following closure. This analysis was used as the basis to estimate the dose to the maximally exposed individual (MEI) for the air pathway per Curie (Ci) of each radionuclide remaining in the combined FTF waste tanks. For the air pathway analysis, several gaseous radionuclides were considered. These included carbon-14 (C-14), chlorine-36 (Cl-36), iodine-129 (I-129), selenium-79 (Se-79), antimony-125 (Sb-125), tin-126 (Sn-126), tritium (H-3), and technetium-99 (Tc-99). The dose to the MEI was estimated at the SRS Boundary during the 100 year institutional control period. For the 10,000 year post closure compliance period, the dose to the MEI was estimated at the 100 m compliance point. For the radon pathway analysis, five parent radionuclides and their progeny were analyzed. These parent radionuclides included uranium-238 (U-238), plutonium-238 (Pu-238), uranium-234 (U-234), thorium-230 (Th-230), and radium-226 (Ra-226). The peak flux of radon-222 due to each parent

Trends in intensive care unit admissions of COPD patients from 2003 to 2013 in Taiwan

Directory of Open Access Journals (Sweden)

Liao KM

2018-06-01

Full Text Available Kuang-Ming Liao,1 Yi-Chen Chen,2 Kuo-Chen Cheng,3 Jhi-Joung Wang,2 Chung-Han Ho2,4 1Department of Internal Medicine, Chi Mei Medical Center, Chiali, Taiwan; 2Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; 3Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan; 4Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan Objective: The objective of this study was to investigate the trends in COPD patients admitted to the intensive care unit (ICU in Taiwan from 2003 to 2013. Patients and methods: A retrospective study was conducted to analyze the available data in the National Health Insurance Research Database compiled by the Taiwan Department of Health. We selected patients admitted to the ICU nationwide from 2003 to 2013. Patients older than 40 years with a diagnosis of COPD were enrolled. The ICU admission date was used as the index date. Baseline comorbidities existing before the index date were identified. The comorbidities of interest included diabetes, hypertension, diabetes mellitus, coronary artery disease, stroke, dyslipidemia, cancer, and end-stage renal disease. Results: The number of COPD patients in the ICU increased from 12,384 in 2003 to 13,308 in 2013 (P<0.0001. The mean age of patients and SD was 76.66±9.48 and 78.32±10.59 in 2003 and 2013, respectively. The percentage of COPD patients aged ≥70 years in the ICU decreased markedly. COPD patients per 10,000 ICU patients decreased for both males and females. The length of ICU stays, and in-hospital mortality increased from 21.58 to 23.14 days and 14.97% to 30.98% from 2003 to 2013, respectively. Conclusion: The number of COPD patients admitted to the ICU in Taiwan increased over the 11-year study period. Increased mean patient age, length of ICU stays, hospital mortality, and comorbidities were observed. The use of a nationwide population-based database allowed for a

Sihtasutus Eesti Rahvuskultuuri Fond võtab 15. oktoobrini vastu...

Index Scriptorium Estoniae

2003-01-01

Võetakse vastu 2004. a. stipendiumide ja kultuuriprojektide finantseerimise taotlusi. Esimest korda määratakse 2003. a. stipendiume järgmistest nimelistest allfondidest: Arvo Nenni ja Ingrid Nenni (Nõges) Fond toetab EKMi eesti kunstipärandi ostmisel, Edmund Valtmani Fond toetab stipendiumiga EKA üliõpilast või alla 30-aastast EKA vilistlast parima graafilise teose eest, Natalie Mei Fond toetab professionaalsete ja tulemuslike lava- ning kostüümikujundajate tegevust ja täiendusõpet jt.

Lennart Meri rännak jätkub ajaloos / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

Ilmunud ka: Eesti Päevaleht 27. märts, lk. 3, pealkiri: VAbariigi presidendi Arnold Rüütli mälestuskõne president Lennart Mei ärasaatmisel Kadriorus, 26. märtsil 2006 SL Õhtuleht 27. märts lk. 2,8, Järva Teataja 28. märts lk. 2. Eesti Vabariigi presidendi Arnold Rüütli mälestuskõne president Lennart Meri riiklikul hüvastijätutseremoonial 26. märtsil 2006 Kadriorus

Overview Kepuasan Pelanggan: Studi Kasus Pelayanan Rijstaffel di Restoran Oasis

OpenAIRE

Adiati, Maria Pia; Subakti, Agung Gita

2015-01-01

Rijstaffel service is not common found in fine dining restaurant in Indonesia. Oasis Restaurant in Jalan Raden Saleh, Jakarta, is a restaurant that is consistent in serving rijstaffel menu. The objective of this research is to analyze the level of consumer satisfaction and service quality in rijstaffel service at Oasis Restaurant. Research used qualitative method with library research by analyzing the questionnaire distributed by Oasis on Mei 2013 with 21 respondents. The result is the indica...

Tussenrapportage Validatie Onderwijsvernieuwingen (Validation Assistant in Instructional Design)

Science.gov (United States)

2007-05-01

validatie onderwij svemieuwingen D)atum mei 2007 Auteur (s) drs. J.P. van Meer drs. G,J. Veldhuis dr. M.L. van Ernmerik M.G. van Schaik Rubricering...als doel om nog beter is het van belang dat het maken van keuzes Auteur (s) passende adviezen te kunnen genereren. binnen een moeilijk grijpbaar...benaderd door de theorie achter de onderwijsconcepten te toetsen aan het oordeel van de expert. Er zijn echter beperkingen in deze opzet denkbaar die

Modern History and Problems of Physical Education in Japan.

OpenAIRE

片桐, 芳雄

1993-01-01

Japanese school is controlled under the strict rules, and student's individuality is often avoided. Going through this kind of schooling, character of most Japanese people devoting themselves to authority or total system has been build up. Physical education at Japanese school also has made one of the core of such education. That is essentially uniform and conservative. The physical education at school and sports in Japan were imported form the Western countries after modernization at the Mei...

Methodiek werkveldonderzoek Hogeschool INHOLLAND

OpenAIRE

Ramaekers, G.W.M.; Allen, J.P.; Heijke, J.A.M.; van Loo, J.B.; van der Velden, R.K.W.

2004-01-01

In mei 2003 heeft Hogeschool INHOLLAND het Researchcentrum voor Onderwijs en Arbeidsmarkt (ROA) van de Universiteit Maastricht opdracht verleend een instrument te ontwikkelen waarmee de mening van het werkveld over de kwaliteit van haar opleidingen in kaart kan worden gebracht. Het instrument is getest in een pilot-project, dat heeft plaatsgevonden in het kader van de accreditatie van een elftal opleidingen van Hogeschool INHOLLAND.Het ROA had bij het uitvoeren van het pilot-project de leidin...

Sensory integration dysfunction affects efficacy of speech therapy on children with functional articulation disorders

OpenAIRE

Tung, Li-Chen; Lin, Chin-Kai; Hsieh, Ching-Lin; Chen, Ching-Chi; Huang, Chin-Tsan; Wang, Chun-Hou

2013-01-01

Li-Chen Tung,1,# Chin-Kai Lin,2,# Ching-Lin Hsieh,3,4 Ching-Chi Chen,1 Chin-Tsan Huang,1 Chun-Hou Wang5,6 1Department of Physical Medicine and Rehabilitation, Chi Mei Medical Center, Tainan, 2Program of Early Intervention, Department of Early Childhood Education, National Taichung University of Education, Taichung, 3School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, 4Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, ...

"Zerkalo" dlja antigeroja / Nikolai Hrustaljov

Index Scriptorium Estoniae

Hrustaljov, Nikolai

2007-01-01

Esimene Andrei Tarkovskile pühendatud filmifestival "Peegel" ("Zerkalo"). Festivali toimumispaigaks on režissööri sünnipaik Jurjevetsi linn Ivanovo oblastis, žürii juhiks Teo Angelopulos. Festivali huvitavamatest filmidest - Valeri Ogorodnikovi "Putina" (Venemaa ; publiku auhind), mehhiklase Gerardo Naranjo "Drama/Mex" (peaauhind), horvaadi Branko Schmidti "Arbuuside vedu" ("Put lubenica"; Mei Sun'ile naisnäitleja auhind), islandlase Ragnar Bragasoni "Lapsed" ("Börn"; Olafur Darri Olafssonile meesnäitleja auhind), serblase Srdjan Golubovici "Lõks" ("Klopka")

Restoring proximal caries lesions conservatively with tunnel restorations

OpenAIRE

Chu, Chun-Hung; Cheung,; Nalliah,Romesh; Mei,May L

2013-01-01

Chun-Hung Chu1, May L Mei,1 Chloe Cheung,1 Romesh P Nalliah2 1Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China; 2Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA Abstract: The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slo...

A Morpholino-based screen to identify novel genes involved in craniofacial morphogenesis

Science.gov (United States)

Melvin, Vida Senkus; Feng, Weiguo; Hernandez-Lagunas, Laura; Artinger, Kristin Bruk; Williams, Trevor

2014-01-01

BACKGROUND The regulatory mechanisms underpinning facial development are conserved between diverse species. Therefore, results from model systems provide insight into the genetic causes of human craniofacial defects. Previously, we generated a comprehensive dataset examining gene expression during development and fusion of the mouse facial prominences. Here, we used this resource to identify genes that have dynamic expression patterns in the facial prominences, but for which only limited information exists concerning developmental function. RESULTS This set of ~80 genes was used for a high throughput functional analysis in the zebrafish system using Morpholino gene knockdown technology. This screen revealed three classes of cranial cartilage phenotypes depending upon whether knockdown of the gene affected the neurocranium, viscerocranium, or both. The targeted genes that produced consistent phenotypes encoded proteins linked to transcription (meis1, meis2a, tshz2, vgll4l), signaling (pkdcc, vlk, macc1, wu:fb16h09), and extracellular matrix function (smoc2). The majority of these phenotypes were not altered by reduction of p53 levels, demonstrating that both p53 dependent and independent mechanisms were involved in the craniofacial abnormalities. CONCLUSIONS This Morpholino-based screen highlights new genes involved in development of the zebrafish craniofacial skeleton with wider relevance to formation of the face in other species, particularly mouse and human. PMID:23559552

Split hand muscle echo intensity index as a reliable imaging marker for differential diagnosis of amyotrophic lateral sclerosis.

Science.gov (United States)

Seok, Hung Youl; Park, Jinseok; Kim, Yoo Hwan; Oh, Ki-Wook; Kim, Seung Hyun; Kim, Byung-Jo

2018-04-17

The objective of this study was to investigate the usefulness of muscle ultrasound in evaluating dissociated small hand muscle atrophy, termed 'split hand', and its feasibility in the diagnosis of amyotrophic lateral sclerosis (ALS). Forty-four patients with ALS, 18 normal subjects and 9 patients with other neuromuscular disorders were included in this study. The hand muscles were divided into three regions, the median-innervated lateral hand muscle group (ML), the ulnar-innervated lateral hand muscle (UL) and the ulnar-innervated medial hand muscle (UM), and the muscle echo intensity (EI) and compound muscle action potential (CMAP) were measured. We calculated the split hand index (SHI) using muscle EI (SHI mEI ) and CMAP (SHI CMAP ) for comparison among groups. The SHI was derived by dividing muscle EI (or CMAP) measured at the ML and UL by that measured at the UM. The SHI mEI was significantly higher in patients with ALS (51.7±28.3) than in normal controls (29.7±9.9) and disease controls with other neuromuscular disorders (36.5±7.3; Pdifferentiating ALS from other neuromuscular disorders and healthy controls. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Kelimpahan Spesies Kelelawar Ordo Chiroptera Di Gua Wilayah Selatan Pulau Lombok NTB

OpenAIRE

dan Gito Hadiprayitno, Siti Rabiatul Fajri, Agil Al Idrus

2014-01-01

A research on diversity of bats of cave in the south area of Lombok island was conducted.Five caves survied for this research were Gale-Gale, Buwun, Kenculit, Raksasa, and cave PantaiSurga. Survey was done during Mart to Mei 2014. Samples of bat were obtained by using Mistnet. The bats were observed and identified in the Biology Laboratorium FMIPA University ofMataram. This research fully identified 12 species from 6 Famili of bats. The species are such as:Hipposederos ater, Rhinolopus simple...

Exploring the experiences of older Chinese adults with comorbidities including diabetes: surmounting these challenges in order to live a normal life

OpenAIRE

Ho, Hsiu-Yu; Chen, Mei-Hui; Lou, Meei-Fang

2018-01-01

Hsiu-Yu Ho,1,2 Mei-Hui Chen,2,3 Meei-Fang Lou1 1School of Nursing, College of Medicine, National Taiwan University, 2Department of Nursing, Yuanpei University of Medical Technology, 3National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, Republic of China Background: Many people with diabetes have comorbidities, even multimorbidities, which have a far-reaching impact on the older adults, their family, and society. However, little is known of the experience of older adult...

CHILI: China Lijiang IFU

Science.gov (United States)

Hao, Lei

2014-07-01

Wide-field IFU technology on medium-size telescope provides a unique science capability that compliments larger future facilities. Here I introduce a program to employ a VIRUS-like unit on the 2.4 meter telescope in GaoMeiGu Observatory in LiJiang, China. We name the instrument "CHILI (China Lijiang IFU)". It will be an IFU with very large field of view at 1.8'x3.6'. We discuss its science capabilities and its potential benefit to the Chinese astronomical community.

The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia

OpenAIRE

Lai, Pauline Siew Mei; Toh,Li Shean; Wong,Kok Thong; Tan,Alex Tong Boon; Low,Bee Yean; Anderson,Claire; Wu,David Bin-Chia

2014-01-01

Li Shean Toh,1 Pauline Siew Mei Lai,2 David Bin-Chia Wu,3 Kok Thong Wong,1 Bee Yean Low,1 Alexander Tong Boon Tan,4 Claire Anderson5 1School of Pharmacy, University of Nottingham, Semenyih, Malaysia; 2Department of Primary Care Medicine, University of Malaya Primary Care Research Group, University of Malaya, Kuala Lumpur, Malaysia; 3School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; 4Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 5Division of Soci...

De Franse aardkastanje [Conopodium majus (Gouan) Loret] nadert de Nederlandse grenzen

OpenAIRE

Weeda, E.J.

1993-01-01

Op 14 mei 1988 toonde Onno de Bruijn me bij Bentheim in Nedersaksen een aantal planten van een Schermbloemige, die daar door enkele Twentse floristen waren opgemerkt en die niet met zekerheid op naam konden worden gebracht. Aanvankelijk dachten we aan Meum athamanticum (wat in vergelijkbare gevallen wel vaker schijnt te gebeuren). Pogingen om één plant in haar geheel te verzamelen, mislukten door de hardheid van de kalkgrond ter plaatse: een bloeistengel zonder ook maar een aanduiding van een...

Solid Phase Synthesis of Polymacromer and Copolymacromer Brushes

Science.gov (United States)

2012-04-25

between immiscible polymers, which dictates the volume in which the interfacial reaction can occur, depends on the nature of thermodynamic interactions...Y.; Beers , K. L.; Byrd, H. C. M.; VanderHart, D. L.; Washburn, N. R. J. Am. Chem. Soc. 2004, 126, 3472−3476. (4) Merrifield, R. B. J. Am. Chem. Soc...Hartmann, L.; Krause, E.; Antonietti, M.; Boerner, H. G. Biomacromolecules 2006, 7, 1239−1244. (16) Mei, Y.; Beers , K. L.; Byrd, H. C. M.; VanderHart, D. L

Análise do comportamento meiótico em Cordia ecalyculata Vell. (Boraginaceae

Directory of Open Access Journals (Sweden)

Damião do Nascimento

2014-07-01

Full Text Available http://dx.doi.org/10.5007/2175-7925.2014v27n4p21 A espécie Cordia ecalyculata pertence à família Boraginaceae, é conhecida popularmente por café de bugre. Para fins medicinais é indicada como tônico, diurético, anti-inflamatório e inibidor do apetite. Visando contribuir para um melhor entendimento da espécie, inflorescências jovens de seis indivíduos foram coletadas e fixadas em solução de etanol e ácido acético (3:1 por 24 h. As lâminas foram preparadas utilizando a técnica de esmagamento e coradas com carmim acético a 1%. Durante a microsporogênese poucas irregularidades foram encontradas, as mais frequentes estão relacionadas à segregação irregular dos cromossomos, tais como: Ascensão precoce para os polos em metáfase I e II, bivalente não orientado em metáfase I e II, e cromossomos retardatários em anáfase I e II, levando a formação de micronúcleos. Outra irregularidade observada esta relacionada a organização das fibras dos fusos em meiose II, que se organizam na forma em T e V. Na configuração de fuso na forma de V ocorreu fusão entre dois núcleos que estavam próximos, formando tríade ao invés de tétrade, levando à formação de micrósporos 2n final da meiose. Entretanto, as irregularidades observadas não comprometeram a fertilidade da espécie em análise, uma vez que a viabilidade dos grãos de pólen variou de 95,42% a 100%.

Mātes-meitas -attiecības Elfrīdes Jelinekas romānā "Klavierspēlētāja"

OpenAIRE

Martiņuka, Jekaterina

2014-01-01

Elfrīdes Jelinekas romānā visvairāk uzminība tiek koncentrēta uz attiecībām starp māti un meitu, kā arī šo attiecību tālāko ietekmi uz galvenās varones dzīvi. Šis darbs sniedz ieskatu pašas rakstnieces dzīvē, kā arī viņas bērnībā, no kurienes arī nākušas romānas vēsmas. Galvenās varones Ērikas uzvedībai ir cēloņi, kas nāk no viņas bērnibas, bet galvenokārt no viņas attiecībām ar pašas māti. Jelineka izveidoja autoritāru tēlu, māti, kura audzina savu bērnu savtīgiem nolūkiem, tajā pašā laik...

Flower Style on Seventeenth Century Agra Buildings

Directory of Open Access Journals (Sweden)

Ali Fuat BAYSAL

2017-12-01

Full Text Available India is a uniquely rich country thanks to its historical characteristics and complex mixture of different races, cultures and religions. The diversity of the religious groups has particularly affected the decorative arts, which have generated another form of diversity and richness. Every religious group built their own houses of worship and decorated them in accordance with their beliefs because of the close relationship between religion and decoration. Many buildings containing Turkish overtones have been constructed in India, particularly in Agra, during the Mughal era. The style of Kara Memi, a sixteenth century Ottoman painter, draws attention with the decoration of the buildings constructed during the Shah Jahan era. Of them, the most popular is the Taj Mahal. It is well known that the Ottomans respected and appreciated the artistic characteristics, particularly the architecture, of the region instead of acting in a dominating manner. Thus, we can consider the relationship between the Ottomans and Mughal Empire is similar only in terms of style. Cooperation was present between them, and artistic transfers between these two empires were thus inevitable.

Uji Alat Pengaduk Sabun Cair Berbahan Baku Limbah Minyak Jelantah Dengan Ekstrak Serai Wangi (Cymbopogon nardus L.), Pandan (Pandanus amaryllifolius Roxb.), dan Jeruk Nipis (Citrus aurantifolia)

OpenAIRE

Rahman, Fariz Faisal

2015-01-01

Use cooking Oil is the remains of frying oil that can not be reused. Therefore a further processing is needed, one of them is to be come liquid soap. The aim of this study was to process used cooking oil into liquid soap using the extract of lemongrass, pandan and lemon. The study was conducted at the Laboratory of Agricultural Engineering and parameters tested at the Food Chemical Analysis Laboratorium Faculty of Agricultural in April 2015 to Mei 2015 by using a non-factorial completely rand...

Browse Author Index - AJOL

African Journals Online (AJOL)

Items 51 - 100 of 222 ... G. Gökçekuş, Laika · Gökbulut, Alper · Gönüllü, Ü · Gören, Ahmet C. Gümüstas, Aysen · Gürpınar, P · Güzel, Y · Gbeassor, M · Gbeassor, M · Gbeassor, Messanvi · Ge, Jian-Jun · Ge, Liangpeng · Ge, Yingliang · Geetha, M · Gelisen, Ilker · Geng, Dong-mei · Geng, S · Geng, W · Geng, Xiu-Li · Geng, Yumei

Automatic and unbiased assessment of competence in colonoscopy

DEFF Research Database (Denmark)

Preisler, Louise; Svendsen, Morten Bo Søndergaard; Søndergaard, Bo

2016-01-01

is the first clinical descriptive report of a novel colonoscopy assessment tool based on Magnetic Endoscopic Imaging (MEI) data and the aim was to gather validity evidence based on the data collected using the "Colonoscopy Progression Score" (CoPS). Methods: We recorded 137 colonoscopy procedures performed...... sources of validity evidence were explored: response process (data collection), internal structure (reliability), relationship to other variables (i. e. operator experience), and consequences of testing (pass/fail). Results: Identical set-ups at all three locations ensured uniform data collection...

Chromosome number and microsporogenesis in Paspalum maritimum (caespitosa group; gramineae

Directory of Open Access Journals (Sweden)

Eleniza de Victor Adamowski

2000-01-01

Full Text Available Despite of economic importance of the genus Paspalum, little or no cytologic information is available for many species. This is the first report about chromosome number and meiotic behavior for P. maritimum. The three accessions collected in Amapá State (North Region of Brazil were tetraploid (2n=4x=40 with the chromosomes associating predominantly as bivalents. The low frequency of multivalents suggested that they were segmental allotetraploids. All accessions showed a low rate of meiotic irregularities, and as a consequence the pollen fertility was high. The results suggested that these accessions presented potential for use in a hybridization program.Apesar da importância econômica do gênero Paspalum, pouca ou nenhuma informação citológica é encontrada para a maioria das espécies. Esta é a primeira descrição sobre número de cromossomos e comportamento meiótico para P. maritimum. Os três acessos coletados no Estado do Amapá mostraram-se tetraplóides (2n=4x=40 com os cromossomos associando-se predominantemente como bivalentes. A baixa ocorrência de associações multivalentes sugere que estes acessos sejam alotetraplóides segmentais. Todos os acessos mostraram uma baixa frequência de anormalidades meióticas e, como consequência, uma alta fertilidade de pólen, mostrando potencial para serem utilizados em programas de hibridização.

The Use of Principal Components in Long-Range Forecasting

Science.gov (United States)

Chern, Jonq-Gong

Large-scale modes of the global sea surface temperatures and the Northern Hemisphere tropospheric circulation are described by principal component analysis. The first and the second SST components well describe the El Nino episodes, and the El Nino index (ENI), suggested in this study, is consistent with the winter Southern Oscillation index (SOI), where this ENI is a composite component of the weighted first and second SST components. The large-scale interactive modes of the coupling ocean-atmosphere system are identified by cross-correlation analysis The result shows that the first SST component is strongly correlated with the first component of geopotential height in lead time of 6 months. In the El Nino-Southern Oscillation (ENSO) evolution, the El Nino mode strongly influences the winter tropospheric circulation in the mid -latitudes for up to three leading seasons. The regional long-range variation of climate is investigated with these major components of the SST and the tropospheric circulation. In the mid-latitude, the climate of the central United States shows a weak linkage with these large-scale circulations, and the climate of the western United States appears to be consistently associated with the ENSO modes. These El Nino modes also show a dominant influence on Eastern Asia as evidenced in Taiwan Mei-Yu patterns. Possible regional long-range forecasting schemes, utilizing the complementary characteristics of the winter El Nino mode and SST anomalies, are examined with the Taiwan Mei-Yu.

The interaction between Xe and F in Si (1 0 0) pre-amorphised with 20 keV Xe and implanted with low energy BF{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Werner, M. [Joule Physics Laboratory, Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom)]. E-mail: m.werner@pgr.salford.ac.uk; Berg, J.A. van den [Joule Physics Laboratory, Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom); Armour, D.G. [Joule Physics Laboratory, Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom); Carter, G. [Joule Physics Laboratory, Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom); Feudel, T. [AMD Saxony LLC and Co. KG, Wilschdorfer Landstrasse, 101 D-01109 Dresden (Italy); Herden, M. [AMD Saxony LLC and Co. KG, Wilschdorfer Landstrasse, 101 D-01109 Dresden (Italy); Bersani, M. [ITC IRST, 38050 Povo, Trento (Italy); Giubertoni, D. [ITC IRST, 38050 Povo, Trento (Italy); Bailey, P. [CCLRC Daresbury Laboratory, Daresbury WA44A (United Kingdom); Noakes, T.C.Q. [CCLRC Daresbury Laboratory, Daresbury WA44A (United Kingdom)

2004-12-15

The pre-amorphisation of Si by Xe{sup +} ions, before source/drain and extension implants, is an attractive alternative to Ge{sup +} or Si{sup +}, as it produces sharper amorphous/crystalline interfaces. Si (1 0 0) samples pre-amorphised with 20 keV Xe{sup +} to a nominal dose of 2E14 cm{sup -2} were implanted with 1 and 3 keV BF{sub 2} {sup +} to doses of 7E14 cm{sup -2}. Samples were annealed at temperatures ranging from 600 to 1130 deg. C and investigated by medium energy ion scattering (MEIS) and secondary ion mass spectrometry (SIMS). Following annealing, it was observed that implanted Xe has interacted with F originating from the BF{sub 2} {sup +} implant. MEIS studies showed that for all annealing conditions, approximately half of the Xe accumulated at depths of 7 nm for the 1 keV and at 13 nm for the 3 keV BF{sub 2} {sup +} implant. This equates to the end of range of B and F within the amorphous Si. SIMS showed that in the pre-amorphised samples, approximately 10% of the F migrates into the bulk and is trapped at the same depth in a {approx}1:1 ratio to Xe. A small fraction of the implanted B is also trapped. The effect is interpreted in terms of the formation of a defect structure within the amorphised Si, leading to F stabilised Xe bubble or XeF compound formation.

Structure of ultrathin films of Co on Cu(111) from normal-incidence x-ray standing wave and medium-energy ion scattering measurements

International Nuclear Information System (INIS)

Butterfield, M.T.; Crapper, M.D.; Noakes, T.C.Q.; Bailey, P.; Jackson, G.J.; Woodruff, D.P.

2000-01-01

Applications of the techniques of normal-incidence x-ray standing wave (NIXSW) and medium-energy ion scattering (MEIS) to the elucidation of the structure of an ultrathin metallic film, Co on Cu(111), are reported. NIXSW and MEIS are shown to yield valuable and complementary information on the structure of such systems, yielding both the local stacking sequence and the global site distribution. For the thinnest films of nominally two layers, the first layer is of entirely fcc registry with respect to the substrate, but in the outermost layer there is significant occupation of hcp local sites. For films up to 8 monolayers (ML) thick, the interlayer spacing of the Co layers is 0.058±0.006 Aa smaller than the Cu substrate (111) layer spacing. With increasing coverage, the coherent fraction of the (1(bar sign)11) NIXSW decreases rapidly, indicating that the film does not grow in a fcc continuation beyond two layers. For films in this thickness range, hcp-type stacking dominates fcc twinning by a ratio of 2:1. The variation of the (1(bar sign)11) NIXSW coherent fraction with thickness shows that the twinning occurs close to the Co/Cu interface. For thicker films of around 20 ML deposited at room temperature, medium-energy ion scattering measurements reveal a largely disordered structure. Upon annealing to 300 deg. C the 20-ML films order into a hcp structure

Relationship between energy intake and chewing index of diets fed to pregnant ewes

DEFF Research Database (Denmark)

Nielsen, Mette Vestergaard; Nadeau, E.; Markussen, Bo

2015-01-01

The objective was to determine whether a linear relationship exists between the metabolizable energy (ME) intake of pregnant ewes and a dietary chewing index (CI). The relationship was studied using five feeding trials with intake data from 108 pregnant ewes, 4 to 1 weeks before lambing, giving...... includes random variation of week within experiment on the intercept and linear fixed effect of week before lambing on parameter k. The maximum daily chewing time, CTmax, for the pregnant ewes was predicted to be 1/(4 × k). The MEI declined linearly with increasing dietary CI (P

Me&i-myyjän taloushallinto -opas

OpenAIRE

Riipi, Jaana-Mari

2015-01-01

Opinnäytetyön toimeksiantajana toimi ruotsalaisen yrityksen Me&i:n Suomen osasto. Me&i myy lasten ja naisten vaatteita kotikutsuilla. Me&i:lla on Suomessa noin 280 toiminimellistä kotikutsumyyjää, jotka toimivat itsenäisinä ammatinharjoittajina ympäri maata. Me&i-myyjien keskuudessa on noussut esiin toive saada Me&i:lta apua ja ohjeistusta kirjanpidollisissa ja verotuksellisissa asioissa. Tämän vuoksi päätettiin tehdä opas, joka kattaa Me&i-myyjän taloushallinnon tärkeimmät osa-alueet. Op...

Boundary Layer Effects on Unsteady Airloads.

Science.gov (United States)

1981-02-01

required for a free stream particle to travel one chord in distance; these Items are identical to those used for the velocity vector plots, Figs. 10...reduced frequency of ’,h(,w iferv si lnifi-ant salp effects in the supercritical flow region. At Re 1 2.6 - 10’ there • i 94 is a higher amplitude, more...tijkin f, I disturbances to travel upstream over i let vit, , , frmw the trailing edge to, the me.i, position which will generally he in t roire , n f ful

Erosion Control of Scour during Construction. Report 5. Experimental Measurements of Refraction and Diffraction Downcoast of an Oblique Breakwater.

Science.gov (United States)

1984-09-01

such as a jetty or shore-connected breakwater. The theory of water wave diffraction can be explained by Huygens’ principle . Each point of an ad...a slowly varying bottom, an asymptotic theory has been developed by Liu and Mei (1976) that accounts for the combined effects ot refraction and... Fundment i" rs t Second Third Fo :rth ,ri,- ATa rronlc Ha rmon i c Ha rme qic Gage s.__ ’ sc 0.33 sec 0.25 sec 0.20 sec 1* 0.n+ 6. .0 (-163) 0.12(-9) 0.01

Liberation of methyl acrylate from metallalactone complexes via M-O ring opening (M = Ni, Pd) with methylation agents

KAUST Repository

Lee, S. Y Tina; Ghani, Amylia Abdul; D'Elia, Valerio; Cokoja, Mirza; Herrmann, Wolfgang A.; Basset, Jean-Marie; Kü hn, Fritz

2013-01-01

Ring opening of various nickela- and palladalactones induced by the cleavage of the M-O bond by methyl trifluoromethanesulfonate (MeOTf) and methyl iodide (MeI) is examined. Experimental evidence supports the mechanism of ring opening by the alkylating agent followed by β-H elimination leading to methyl acrylate and a metal-hydride species. MeOTf shows by far higher efficiency in the lactone ring opening than any other methylating agent including the previously reported methyl iodide. © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Syntéza v létajících nanoreaktorech: hydridy vzácných plynů

Czech Academy of Sciences Publication Activity Database

Slavíček, Petr; Ončák, Milan; Poterya, Viktoriya; Fárník, Michal

2008-01-01

Roč. 102, č. 7 (2008), s. 467-473 ISSN 0009-2770 R&D Projects: GA AV ČR KAN400400651; GA ČR GA203/06/1290 Grant - others:GA ČR GP203/07/P449 Institutional research plan: CEZ:AV0Z40400503 Keywords : rare-gas * ab-initio calculation * molecules Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.593, year: 2008

STATUS TROFIK PERAIRAN RAWA PENING DITINJAU DARI KANDUNGAN UNSUR HARA (NO3 dan PO4 SERTA KLOROFIL-a

Directory of Open Access Journals (Sweden)

Naila Zulfiah

2016-03-01

Full Text Available Danau Rawa Pening merupakan danau alami yang multi fungsi yaitu sebagai pembangkit listrik, irigasi, perikanan, air baku dan pariwisata. Aktivitas antropogenik manusia mendorong terjadinya perubahan status trofik perairan. Ledakan populasi fitoplankton dan tumbuhan air terapung merupakan indikasi terjadinya eutrofikasi  di danau ini. Tujuan penelitian ini adalah untuk mengetahui status terkini kondisi kesuburan Perairan Rawa Pening dengan pendekatan nilai unsur hara (nitrat dan fosfat serta hubungannya dengan klorofil-a. Penelitian dilaksanakan pada bulan Mei-Juni 2007 di Perairan Rawa Pening. Parameter kimia seperti nitrat, fosfat dan klorofil-a dianalisa di laboratorium menggunakan metode spektrofotometri. Selain itu dilakukan pengukuran insitu beberapa parameter fisika dan kimia (suhu, kecerahan, kedalaman dan pH. Hubungan antara nitrat dan fosfat terhadap klorofil-a dianalisa dengan regresi linier berganda menggunakan software Excel 2007. Hasil penelitian menunjukkan bahwa kisaran nilai nitrat, fosfat dan klorofil-a pada Bulan Mei dan Juni masing-masing adalah 1,38–2,18 mg/L dan 1,32–2,12 mg/L (eutrofik; 0,013–0,030 mg/L dan 0,012–0,031 mg/L (mesotrofik serta 4,67-7,22 mg/L dan 4,71–7,30 mg/L (mesotrofik. Persamaan hubungan antara nitrat dan fosfat terhadap klorofil pada Bulan Mei dan Juni sebagai berikut Y = 0,549 + 2,599 X1 + 36,513 X2 (R2=0,97 dan Y = 1,457 + 1,628 X1 + 73,638 X2 (R2=0,97. Peningkatan kandungan klorofil-a di Rawa Pening berbanding lurus dengan kandungan nitrat dan fosfat. Konsentrasi nitrat pada Bulan Mei sangat mempengaruhi konsentrasi klorofil sementara pada Bulan Juni terjadi sebaliknya dimana fosfat yang berpengaruh besar terhadap klorofil-a.   Rawa Pening Lake is a natural lake that has multi-function as electricity  power, irrigation, fisheries, raw water as well as tourism. Human anthropogenic activities around lake lead to the changes of trophic status of waters. Eutrophycation indicated by blooming

Autotetraploidia e número cromossómico em uma cultivar de Panicum maximum Jacq. (Gramineae / Poaceae

Directory of Open Access Journals (Sweden)

Caetano Creuci Maria

2006-06-01

Full Text Available

O presente trabalho teve por objetivo avaliar o comportamento citológico e em especial o nível de ploidia de uma cultivar de P. maximum, denomi­nada Tanzânia, que, na realidade, é um ecótipo selvagem de origem africana. Foi empregada a metodologia convencional para estudos meióticos. As inflorescências foram fixadas em álcool acético 3:1 por 24 horas, transferidas para álcool a 70% e conservadas sob refrigeração. A técnica de esmaga­mento foi usada no preparo das lâminas. O corante foi o carmim propiônico a 1%. Foi considerado um mínimo de 200 células por planta. De forma geral, anormalidades meióticas ocorreram em 20% das células mães de pólen analisadas. Em todas as plantas avaliadas, o número de cromossomos observado nas diacineses foi 36. Entre 109 diacineses onde se realizou a contagem do número de cromossomos e se verificou os tipos de associações cromossômicas, 99 apresentaram multivalentes, com predomínio de tetravalentes. Tal ocorrência indica autotetraploidia, onde 2n=4x=36.

Palavras-chave: associações cromossômicas multivalentes, autotetraplóide, cv. Tanzânia, número cromossômico.

Interdecadal variations of East Asian summer monsoon northward propagation and influences on summer precipitation over East China

Science.gov (United States)

Jiang, Z.; Yang, S.; He, J.; Li, J.; Liang, J.

2008-08-01

The interdecadal variation of northward propagation of the East Asian Summer Monsoon (EASM) and summer precipitation in East China have been investigated using daily surface rainfall from a dense rain gauge network in China for 1957 2001, National Center for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis, European Center for Medium-Range Weather Forecast (ECMWF) reanalysis, and Global Mean Sea Level Pressure Dataset (GMSLP2) from Climatic Research Unit (CRU). Results in general show a consistent agreement on the interdecadal variability of EASM northward propagations. However, it appears that the interdecadal variation is stronger in NCEP than in ECMWF and CRU datasets. A newly defined normalized precipitation index (NPI), a 5-day running mean rainfall normalized with its standard deviation, clearly depicts the characteristics of summer rainbelt activities in East China in terms of jumps and durations during its northward propagations. The EASM northward propagation shows a prominent interdecadal variation. EASM before late 1970s had a rapid northward advance and a northern edge beyond its normal position. As a result, more summer rainfall occurred for the North China rainy season, Huaihe-River Mei-Yu, and South China Mei-Yu. In contrast, EASM after late 1970s had a slow northward movement and a northern edge located south of its normal position. Less summer precipitation occurred in East China except in Yangtze River basin. The EASM northernmost position (ENP), northernmost intensity (ENI), and EASM have a complex and good relationship at interdecadal timescales. They have significant influences on interdecadal variation of the large-scale precipitation anomalies in East China.

Extreme expansion of NBS-encoding genes in Rosaceae.

Science.gov (United States)

Jia, YanXiao; Yuan, Yang; Zhang, Yanchun; Yang, Sihai; Zhang, Xiaohui

2015-05-03

Nucleotide binding site leucine-rich repeats (NBS-LRR) genes encode a large class of disease resistance (R) proteins in plants. Extensive studies have been carried out to identify and investigate NBS-encoding gene families in many important plant species. However, no comprehensive research into NBS-encoding genes in the Rosaceae has been performed. In this study, five whole-genome sequenced Rosaceae species, including apple, pear, peach, mei, and strawberry, were analyzed to investigate the evolutionary pattern of NBS-encoding genes and to compare them to those of three Cucurbitaceae species, cucumber, melon, and watermelon. Considerable differences in the copy number of NBS-encoding genes were observed between Cucurbitaceae and Rosaceae species. In Rosaceae species, a large number and a high proportion of NBS-encoding genes were observed in peach (437, 1.52%), mei (475, 1.51%), strawberry (346, 1.05%) and pear (617, 1.44%), and apple contained a whopping 1303 (2.05%) NBS-encoding genes, which might be the highest number of R-genes in all of these reported diploid plant. However, no more than 100 NBS-encoding genes were identified in Cucurbitaceae. Many more species-specific gene families were classified and detected with the signature of positive selection in Rosaceae species, especially in the apple genome. Taken together, our findings indicate that NBS-encoding genes in Rosaceae, especially in apple, have undergone extreme expansion and rapid adaptive evolution. Useful information was provided for further research on the evolutionary mode of disease resistance genes in Rosaceae crops.

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.

Science.gov (United States)

Novak, Rachel L; Harper, David P; Caudell, David; Slape, Christopher; Beachy, Sarah H; Aplan, Peter D

2012-12-01

NUP98-HOXD13 (NHD13) and CALM-AF10 (CA10) are oncogenic fusion proteins produced by recurrent chromosomal translocations in patients with acute myeloid leukemia (AML). Transgenic mice that express these fusions develop AML with a long latency and incomplete penetrance, suggesting that collaborating genetic events are required for leukemic transformation. We employed genetic techniques to identify both preleukemic abnormalities in healthy transgenic mice as well as collaborating events leading to leukemic transformation. Candidate gene resequencing revealed that 6 of 27 (22%) CA10 AMLs spontaneously acquired a Ras pathway mutation and 8 of 27 (30%) acquired an Flt3 mutation. Two CA10 AMLs acquired an Flt3 internal-tandem duplication, demonstrating that these mutations can be acquired in murine as well as human AML. Gene expression profiles revealed a marked upregulation of Hox genes, particularly Hoxa5, Hoxa9, and Hoxa10 in both NHD13 and CA10 mice. Furthermore, mir196b, which is embedded within the Hoxa locus, was overexpressed in both CA10 and NHD13 samples. In contrast, the Hox cofactors Meis1 and Pbx3 were differentially expressed; Meis1 was increased in CA10 AMLs but not NHD13 AMLs, whereas Pbx3 was consistently increased in NHD13 but not CA10 AMLs. Silencing of Pbx3 in NHD13 cells led to decreased proliferation, increased apoptosis, and decreased colony formation in vitro, suggesting a previously unexpected role for Pbx3 in leukemic transformation. Published by Elsevier Inc.

Purex Plant comparison with 40 CFR 61, subpart H, and other referenced guidelines for the Product Removal (PR) (296-A-1) stack

International Nuclear Information System (INIS)

Lohrasbi, J.

1994-08-01

Dose calculations for atmospheric radionuclide releases from the Hanford Site for calendar year (CY) 1992 were performed by Pacific Northwest Laboratory (PNL) using the approved US Environmental Protection Agency (EPA) CAP-88 computer model. Emissions from discharge points in the Hanford Site 100, 200, 300, 400, and 600 areas were calculated based on results of analyses of continuous and periodic sampling conducted at the discharge points. These calculated emissions were provided for inclusion in the CAP-88 model by area and by individual facility for those facilities having the potential to contribute more than 10 percent of the Hanford Site total or to result in an impact of greater than 0.1 mrem per year to the maximally exposed individual (MEI). Also included in the assessment of offsite dose modeling are the measured radioactive emissions from all Hanford Site stacks that have routine monitoring performed. Record sampling systems have been installed on all stacks and vents that use exhaust fans to discharge air that potentially may carry airborne radioactivity. Estimation of activity from ingrowth of long-lived radioactive progeny is not included in the CAP-88 model; therefore, the Hanford Site GENII code (Napier et al. 1988) was used to supplement the CAP-88 dose calculations. When the dose to the MEI located in the Ringold area was calculated, the effective dose equivalent (EDE) from combined Hanford Site radioactive airborne emissions was shown to be 3.7E-03 mrem. This value was reported in the annual air emission report prepared for the Hanford Site (RL 1993)

High resolution medium energy ion scattering study of silicon oxidation and oxy nitridation

International Nuclear Information System (INIS)

Gusev, E.P.; Lu, H.C.; Garfunkel, E.; Gustafsson, T.

1998-01-01

Full text: Silicon oxide is likely to remain the material of choice for gate oxides in microelectronics for the foreseeable future. As device become ever smaller and faster, the thickness of these layers in commercial products is predicted to be less than 50 Angstroms in just a few years. An understanding of such devices will therefore likely to be based on microscopic concepts and should now be investigated by atomistic techniques. With medium energy ion scattering (MEIS) using an electrostatic energy analyzer, depth profiling of thin (<60 Angstroms) silicon oxide films on Si(100) with 3 - 5 Angstroms depth resolution in the near region has been done. The growth mechanism of thin oxide films on Si(100) has been studied, using sequential oxygen isotope exposures. It is found that the oxide films are stoichiometric to within approx. 10 Angstroms of the interface. It is also found that the oxidation reactions occur at the surface, in the transition region and at interface, with only the third region being included in the conventional (Deal-Grove) model for oxide formation. Nitrogen is sometimes added to gate oxides, as it has been found empirically that his improves some of the electrical properties. The role, location and even the amount of nitrogen that exists in such films are poorly understood, and represent interesting analytical challenges. MEIS data will be presented that address these questions, measured for a number of different processing conditions. We have recently demonstrated how to perform nitrogen nano-engineering in such ultrathin gate dielectrics, and these results will also be discussed

Determination of imidazole derivatives by micellar electrokinetic chromatography combined with solid-phase microextraction using activated carbon-polymer monolith as adsorbent.

Science.gov (United States)

Shih, Yung-Han; Lirio, Stephen; Li, Chih-Keng; Liu, Wan-Ling; Huang, Hsi-Ya

2016-01-08

In this study, an effective method for the separation of imidazole derivatives 2-methylimidazole (2-MEI), 4- methylimidazole (4-MEI) and 2-acetyl-4-tetrahydroxybutylimidazole (THI) in caramel colors using cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography (CSEI-sweeping-MEKC) was developed. The limits of detection (LOD) and quantitation (LOQ) for the CSEI-sweeping-MEKC method were in the range of 4.3-80μgL(-1) and 14-270μgL(-1), respectively. Meanwhile, a rapid fabrication activated carbon-polymer (AC-polymer) monolithic column as adsorbent for solid-phase microextraction (SPME) of imidazole colors was developed. Under the optimized SPME condition, the extraction recoveries for intra-day, inter-day and column-to-column were in the range of 84.5-95.1% (<6.3% RSDs), 85.6-96.1% (<4.9% RSDs), and 81.3-96.1% (<7.1% RSDs), respectively. The LODs and LOQs of AC-polymer monolithic column combined with CSEI-sweeping-MEKC method were in the range of 33.4-60.4μgL(-1) and 111.7-201.2μgL(-1), respectively. The use of AC-polymer as SPME adsorbent demonstrated the reduction of matrix effect in food samples such as soft drink and alcoholic beverage thereby benefiting successful determination of trace-level caramel colors residues using CSEI-sweeping-MEKC method. The developed AC-polymer monolithic column can be reused for more than 30 times without any significant loss in the extraction recovery for imidazole derivatives. Copyright © 2015 Elsevier B.V. All rights reserved.

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells

Directory of Open Access Journals (Sweden)

Bowen Xu

2018-03-01

Full Text Available Summary: Self-renewal and differentiation of adult stem cells are tightly regulated partly through configuration of chromatin structure by chromatin remodelers. Using knockout mice, we here demonstrate that bromodomain PHD finger transcription factor (BPTF, a component of the nucleosome remodeling factor (NURF chromatin-remodeling complex, is essential for maintaining the population size of hematopoietic stem/progenitor cells (HSPCs, including long-term hematopoietic stem cells (HSCs. Bptf-deficient HSCs are defective in reconstituted hematopoiesis, and hematopoietic-specific knockout of Bptf caused profound defects including bone marrow failure and anemia. Genome-wide transcriptome profiling revealed that BPTF loss caused downregulation of HSC-specific gene-expression programs, which contain several master transcription factors (Meis1, Pbx1, Mn1, and Lmo2 required for HSC maintenance and self-renewal. Furthermore, we show that BPTF potentiates the chromatin accessibility of key HSC “stemness” genes. These results demonstrate an essential requirement of the chromatin remodeler BPTF and NURF for activation of “stemness” gene-expression programs and proper function of adult HSCs. : Wang and colleagues show that a chromatin remodeler, BPTF, sustains appropriate functions of hematopoietic stem/progenitor cells (HSPCs. BPTF loss causes bone marrow failure and anemia. The authors further define a BPTF-dependent gene-expression program in HSPCs, which contains key HSC stemness factors. These results demonstrate an essential requirement of the BPTF-associated chromatin remodelers for HSC functionality and adult hematopoiesis. Keywords: Bptf, hematopoietic stem cells, chromatin remodeler, Meis1, Pbx1, Mn1, DNA accessibility, NURF, AP1 complex

Mechanical Analysis Of Limestone In Jaya, Lhong, And Lhoknga

Directory of Open Access Journals (Sweden)

Raihan .

2012-09-01

Full Text Available Research about mechanical analysis of limestone in District Jaya, Lhong, and Lhoknga has been done from Dec. 2011 to Mei 2012. This study aim is to classify the limestones based on physical and mechanical tests as well as identify opportunities limestone utilization in accordance with the SII 0378-80 as a condition of quality natural stone for building. Research have been done by testing compressive strength, modulus Young, wear, specific gravity, porosity, and absorption. The result shows that the limestones are qualified natural stone for building the foundation, curbstone, stone and ornamental stone or paste.

UNIONES EN HENDIDURA Y SU PAPEL FUNCIONAL EN EL TRACTO REPRODUCTOR FEMENINO

OpenAIRE

Brañes O,María C.; Sáez R,Alejandra; Villalón B,Manuel J; Sáez C,Juan C

2004-01-01

En el aparato reproductor femenino se expresan diferentes conexinas (Cxs), proteínas que forman canales de uniones en hendidura (CUH) entre células en contacto, permitiendo la coordinación de respuestas metabólicas y/o eléctricas de grupos celulares. Los CUH jugarían un papel relevante en el desarrollo de las células de la granulosa, ya que permiten la comunicación heteróloga entre el ovocito y las células del cúmulo manteniendo la detención meiótica. En la trompa de Falopio, los CUH coordina...

Overview Kepuasan Pelanggan: Studi Kasus Pelayanan Rijstaffel di Restoran Oasis

Directory of Open Access Journals (Sweden)

Maria Pia Adiati

2016-08-01

Full Text Available Rijstaffel service is not common found in fine dining restaurant in Indonesia. Oasis Restaurant in Jalan Raden Saleh, Jakarta, is a restaurant that is consistent in serving rijstaffel menu. The objective of this research is to analyze the level of consumer satisfaction and service quality in rijstaffel service at Oasis Restaurant. Research used qualitative method with library research by analyzing the questionnaire distributed by Oasis on Mei 2013 with 21 respondents. The result is the indicators which got excellence point were service, ambience, value for money, food; and the indicator which got good point was home band and vocal group.

Perspectivas para conservação e reúso de água na indústria de alimentos - estudo de uma unidade de processamento de frangos.

OpenAIRE

Erika Myho Matsumura

2007-01-01

Na presente pesquisa foi abordado o conceito de conservação e reúso de água na indústria alimentícia, buscando mostrar a potencialidade de redução do consumo desse recurso. Foram avaliadas questões relacionadas à disponibilidade hídrica nos mananciais superficiais e subterrâneos quanto à sua quantidade e qualidade adequadas para consumo, além da questão legal da cobrança pelo uso da água. Essas provavelmente passarão a ser relevantes num futuro próximo, pressionando as indústrias a buscar mei...

Early forest fire detection using low-energy hydrogen sensors

Directory of Open Access Journals (Sweden)

K. Nörthemann

2013-11-01

Full Text Available Most huge forest fires start in partial combustion. In the beginning of a smouldering fire, emission of hydrogen in low concentration occurs. Therefore, hydrogen can be used to detect forest fires before open flames are visible and high temperatures are generated. We have developed a hydrogen sensor comprising of a metal/solid electrolyte/insulator/semiconductor (MEIS structure which allows an economical production. Due to the low energy consumption, an autarkic working unit in the forest was established. In this contribution, first experiments are shown demonstrating the possibility to detect forest fires at a very early stage using the hydrogen sensor.

Kasus Diabetes Mellitus Pada Kucing Lokal

Directory of Open Access Journals (Sweden)

Ayu Fitriani

2016-10-01

Full Text Available Penelitian ini bertujuan mengamati gejala klinis, gambaran hematologi dan kimia klinis pada penderita DM. Penelitian dilaksanakan di Bali Veterinary Clinic Pererena Bali. Waktu penelitian berlangsung pada akhir bulan Maret sampai bulan Mei 2015. Kucing penderita DM memiliki gejala klinis polyuria, polydipsia, polyphagia, penurunan berat badan, luka basah yang tidak kunjung sembuh, gusi pucat kekuningan, peningkatan temperatur tubuh, anoreksia. Pada uji darah lengkap didapatkan hasil White Blood Cell, Red Blood Cell, Hematocrite, Platelet, dan Hemoglobin rendah sedangkan Lymphocytes tinggi. Pada uji glukosa darah menunjukan bahwa glukosa darah tinggi. Tes fungsi hati menunjukkan bahwa AST tinggi tetapi ALT normal.

Analysis of Maximum Reasonably Foreseeable Accidents for the Yucca Mountain Draft Environmental Impact Statement (DEIS)

International Nuclear Information System (INIS)

Ross, S.B.; Best, R.E.; Maheras, S.J.; McSweeney, T.I.

2001-01-01

Accidents could occur during the transportation of spent nuclear fuel and high-level radioactive waste. This paper describes the risks and consequences to the public from accidents that are highly unlikely but that could have severe consequences. The impact of these accidents would include those to a collective population and to hypothetical maximally exposed individuals (MEIs). This document discusses accidents with conditions that have a chance of occurring more often than 1 in 10 million times in a year, called ''maximum reasonably foreseeable accidents''. Accidents and conditions less likely than this are not considered to be reasonably foreseeable

Environmental impact analysis for the main accidental sequences of ignitor

International Nuclear Information System (INIS)

Carpignano, A.; Francabandiera, S.; Vella, R.; Zucchetti, M.

1996-01-01

A safety analysis study has been applied to the Ignitor machine using Probabilistic Safety Assessment. The main initiating events have been identified, and accident sequences have been studied by means of traditional methods such as Failure Mode and Effect Analysis (FMEA), Fault Trees (FT) and Event Trees (ET). The consequences of the radioactive environmental releases have been assessed in terms of Effective Dose Equivalent (EDEs) to the Most Exposed Individuals (MEI) of the chosen site, by means of a population dose code. Results point out the low enviromental impact of the machine. 13 refs., 1 fig., 3 tabs

Iekšējās kontroles sistēma uzņēmumā "ABC"

OpenAIRE

Lipse, Linda

2011-01-01

Iekšējās kontroles sistēmas ir būtiska katra uzņēmuma darbības sastāvdaļa. Darba mērķis ir izpētīt uzņēmuma “ABC” iekšējās kontroles sistēmu, novērtēt tās atbilstību darbā pētītajām iekšējās kontroles sistēmas teorētiskajām prasībām un izstrādāt priekšlikumus uzņēmuma „ABC” iekšējās kontroles sistēmas pilnveidošanai. Darbā ir trīs daļas, pirmajā daļā izpētīta teorētiskā bāze par iekšējās kontroles sistēmu, otrajā daļā - iekšējās kontroles sistēmas izveidošana un ieviešana, trešajā daļā izpētī...

Interhemispheric temperature difference as a predictor of boreal winter ENSO

Science.gov (United States)

Piskozub, Jacek; Gutowska, Dorota

2013-04-01

We use statistical analysis to show statistically significant relationship between the boreal winter MEI index of ENSO and HadCRUT3 temperature difference between Northern and Southern hemispheres (NH - SH) during the preceding summer. Correlation values increase (in absolute terms) if the correlated time periods are increased from month to seasonal length. For example December and January (DJ) MEI values anticorrelate stronger with the preceding MJJA period than with any of the four months taken separately. We believe this is further evidence that the correlation is caused by a real physical process as increase of the averaging period tends to reduce statistical noise. The motivation for looking for such a relationship comes from review of literature on paleoclimatic ENSO behavior. We have noticed that in many cases relatively cold NH coincided with "strong ENSO" (frequent El Niños), for example the Ice Age periods and Little Ice Age. On the other hand periods of relatively warm NH (the Holocene climate optimum or Medieval Climate Anomaly) are coincident with frequent or even "permanent" La Niñas. This relationship suggest the influence of the position of Intertropical Convergence Zone (ITCZ) on the frequency of El Niños. The simplest physical mechanism of the relationship is that the positive (negative) NH-SH temperature difference causes a north (south) shift of ITCZ with a parallel shift of trade wind zones. The North-South orographic difference between the Panama Isthmus and the South America may cause stronger (weaker) trade winds in Eastern Tropical Pacific increasing (decreasing) the thermochemical tilt which, in turn, causes a more negative (positive) ENSO values. Of course this may be only a first approximation of the real mechanism of this "teleconnection". The correlations we have found are not strong even if statistically significant. For example, the MJJA NH-SH temperature vs. DJ MEI correlation has r = -0.28 implying it explains only 8% of boreal

Avaliação de anomalias meióticas de oócitos em pacientes com síndrome dos ovários policísticos submetidas à estimulação ovariana Evaluation of meiotic abnormalities of oocytes from polycystic ovary syndrome patients submitted to ovarian stimulation

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Rodolpho Cruz Vieira

2008-05-01

Full Text Available OBJETIVO: avaliar o fuso meiótico e a distribuição cromossômica de oócitos maturados in vitro, obtidos de ciclos estimulados de mulheres inférteis com síndrome dos ovários policísticos (SOP e fatores masculino e/ou tubário de infertilidade (Grupo Controle e comparar as taxas de maturação in vitro (MIV entre os dois grupos avaliados. MÉTODOS: cinco pacientes inférteis com SOP e oito pacientes controles, submetidas à estimulação ovariana para injeção intracitoplasmática de espermatozóide, foram selecionadas prospectiva e consecutivamente, e constituíram os grupos de estudo e Controle, respectivamente. Oócitos imaturos captados após estimulação ovariana para a realização de injeção intracitoplasmática de espermatozóide (21 e 29, respectivamente, nos Grupos SOP e Controle foram submetidos à MIV. Apenas os oócitos que apresentaram a extrusão do primeiro corpúsculo polar após a MIV foram fixados e submetidos à imunocoloração e análise por microscopia de fluorescência para avaliação morfológica do fuso e da distribuição cromossômica. A análise estatística foi realizada utilizando o teste exato de Fisher, com significância estatística quando pPURPOSE: to evaluate the meiotic spindle and the chromosome distribution of in vitro matured oocytes obtained from stimulated cycles of infertile women with polycystic ovary syndrome (PCOS and with male factor and/or tubal infertility (Control Group and compare in vitro maturation (IVM rates between the groups analyzed. METHODS: five infertile patients with PCOS and eight controls, submitted to stimulated cycles for intracytoplasmic sperm injection, were selected prospectively and consecutively, and respectively assigned to the study group and the Control Group. Immature oocytes (21 and 29, respectively, from PCOS and Control Group were submitted to IVM. After IVM, oocytes with first polar body extruded were fixed and submitted to immunostaining and fluorescence

Technical note: Relationship between infrared thermography and heat production in young bulls.

Science.gov (United States)

Gomes, R A; Busato, K C; Ladeira, M M; Johnson, K A; Galvão, M C; Rodrigues, A C; Lourençoni, D; Chizzotti, M L

2016-03-01

The traditional techniques to measure heat production (HP) are calorimetry (direct and indirect) and comparative slaughter. Both methods are expensive and require extensive amounts of time and infrastructure. Infrared thermography (IRT) could be a faster and less expensive alternative to estimate cattle HP. The objective of this project was to evaluate the use of the IRT technique as an indicator of HP in cattle. A total of 24 bulls (12 Nellore and 12 Black Angus) with initial BW of 380 ± 7 kg were used. Initially, 4 animals of each breed were harvested (baseline animals) and simple regressions were developed for each breed from these baseline animals to estimate the initial chemical composition of the remaining bulls. Eight animals of each breed were fed a silage/concentrate diet for ad libitum intake in individual stalls. On the 25th, 50th, and 75th experimental day, infrared thermal images (Fluke Ti 55ft; Fluke Corporation) were taken of each animal's face to access skin and ocular surface temperatures. A metabolism trial was conducted to estimate the ME intake (MEI). After 84 experimental days, the cattle were harvested and retained energy (RE) and HP were calculated. The data were analyzed using the MIXED and REG procedures of SAS adopting a significance level of 0.05. Angus cattle had a greater daily MEI, HP, and skin and eye temperatures than Nellore. We found significant correlations ( ≤ 0.005) between daily HP and maximum ( = 0.65) and average skin temperatures ( = 0.65) and maximum ( = 0.65) and average ocular surface ( = 0.69) temperatures recorded on d 50. Infrared thermography has potential to be used to evaluate HP in cattle.

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

International Nuclear Information System (INIS)

Liebe, B.; Petukhova, G.; Barchi, M.; Bellani, M.; Braselmann, H.; Nakano, T.; Pandita, T.K.; Jasin, M.; Fornace, A.; Meistrich, M.L.; Baarends, W.M.; Schimenti, J.; Lange, T. de; Keeney, S.; Camerini-Otero, R.D.; Scherthan, H.

2006-01-01

Meiosis pairs and segregates homologous chromosomes and thereby forms haploid germ cells to compensate the genome doubling at fertilization. Homologue pairing in many eukaryotic species depends on formation of DNA double strand breaks (DSBs) during early prophase I when telomeres begin to cluster at the nuclear periphery (bouquet stage). By fluorescence in situ hybridization criteria, we observe that mid-preleptotene and bouquet stage frequencies are altered in male mice deficient for proteins required for recombination, ubiquitin conjugation and telomere length control. The generally low frequencies of mid-preleptotene spermatocytes were significantly increased in male mice lacking recombination proteins SPO11, MEI1, MLH1, KU80, ubiquitin conjugating enzyme HR6B, and in mice with only one copy of the telomere length regulator Terf1. The bouquet stage was significantly enriched in Atm -/- , Spo11 -/- , Mei1 m1Jcs/m1Jcs , Mlh1 -/- , Terf1 +/- and Hr6b -/- spermatogenesis, but not in mice lacking recombination proteins DMC1 and HOP2, the non-homologous end-joining DNA repair factor KU80 and the ATM downstream effector GADD45a. Mice defective in spermiogenesis (Tnp1 -/- , Gmcl1 -/- , Asm -/- ) showed wild-type mid-preleptotene and bouquet frequencies. A low frequency of bouquet spermatocytes in Spo11 -/- Atm -/- spermatogenesis suggests that DSBs contribute to the Atm -/- -correlated bouquet stage exit defect. Insignificant changes of bouquet frequencies in mice with defects in early stages of DSB repair (Dmc1 -/- , Hop2 -/- ) suggest that there is an ATM-specific influence on bouquet stage duration. Altogether, it appears that several pathways influence telomere dynamics in mammalian meiosis

Determinants of health care expenditures and the contribution of associated factors: 16 cities and provinces in Korea, 2003-2010.

Science.gov (United States)

Han, Kimyoung; Cho, Minho; Chun, Kihong

2013-11-01

The purpose of this study was to classify determinants of cost increases into two categories, negotiable factors and non-negotiable factors, in order to identify the determinants of health care expenditure increases and to clarify the contribution of associated factors selected based on a literature review. The data in this analysis was from the statistical yearbooks of National Health Insurance Service, the Economic Index from Statistics Korea and regional statistical yearbooks. The unit of analysis was the annual growth rate of variables of 16 cities and provinces from 2003 to 2010. First, multiple regression was used to identify the determinants of health care expenditures. We then used hierarchical multiple regression to calculate the contribution of associated factors. The changes of coefficients (R(2)) of predictors, which were entered into this analysis step by step based on the empirical evidence of the investigator could explain the contribution of predictors to increased medical cost. Health spending was mainly associated with the proportion of the elderly population, but the Medicare Economic Index (MEI) showed an inverse association. The contribution of predictors was as follows: the proportion of elderly in the population (22.4%), gross domestic product (GDP) per capita (4.5%), MEI (-12%), and other predictors (less than 1%). As Baby Boomers enter retirement, an increasing proportion of the population aged 65 and over and the GDP will continue to increase, thus accelerating the inflation of health care expenditures and precipitating a crisis in the health insurance system. Policy makers should consider providing comprehensive health services by an accountable care organization to achieve cost savings while ensuring high-quality care.

Body composition and net energy requirements of Brazilian Somali lambs

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Elzânia S. Pereira

2014-12-01

Full Text Available The aim of this study was to determine the energy requirements for maintenance (NEm and growth of 48 Brazilian Somali ram lambs with an average initial body weight of 13.47±1.76 kg. Eight animals were slaughtered at the trials beginning as a reference group to estimate the initial empty body weight (EBW and body composition. The remaining animals were assigned to a randomised block design with eight replications per block and five diets with increasing metabolisable energy content (4.93, 8.65, 9.41, 10.12 and 11.24 MJ/kg dry matter. The logarithm of heat production was regressed against metabolisable energy intake (MEI, and the NEm (kJ/kg0.75 EBW/day were estimated by extrapolation, when MEI was set at zero. The NEm was 239.77 kJ/kg0.75 EBW/day. The animal’s energy and EBW fat contents increased from 11.20 MJ/kg and 208.54 g/kg to 13.54 MJ/kg and 274.95 g/kg of EBW, respectively, as the BW increased from 13 to 28.70 kg. The net energy requirements for EBW gain increased from 13.79 to 16.72 MJ/kg EBW gain for body weights of 13 and 28.70 kg. Our study indicated the net energy requirements for maintenance in Brazilian Somali lambs were similar to the values commonly recommended by the United States’ nutritional system, but lower than the values recommended by Agricultural Research Council and Commonwealth Scientific and Industrial Research Organization. Net requirements for weight gain were less compared to the values commonly recommended by nutritional system of the United States.

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

Science.gov (United States)

Jakovcevski, Mira; Ruan, Hongyu; Shen, Erica Y; Dincer, Aslihan; Javidfar, Behnam; Ma, Qi; Peter, Cyril J; Cheung, Iris; Mitchell, Amanda C; Jiang, Yan; Lin, Cong L; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Akbarian, Schahram

2015-04-01

Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain largely unexplored. We report that neuronal ablation of the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal forebrain and adult prefrontal cortex (PFC) is associated with increased anxiety and robust cognitive deficits without locomotor dysfunction. In contrast, only mild behavioral phenotypes were observed after ablation of the Mll1 ortholog Kmt2b/Mll2 in PFC. Impaired working memory after Kmt2a/Mll1 ablation in PFC neurons was associated with loss of training-induced transient waves of Arc immediate early gene expression critical for synaptic plasticity. Medial prefrontal layer V pyramidal neurons, a major output relay of the cortex, demonstrated severely impaired synaptic facilitation and temporal summation, two forms of short-term plasticity essential for working memory. Chromatin immunoprecipitation followed by deep sequencing in Mll1-deficient cortical neurons revealed downregulated expression and loss of the transcriptional mark, trimethyl-H3K4, at <50 loci, including the homeodomain transcription factor Meis2. Small RNA-mediated Meis2 knockdown in PFC was associated with working memory defects similar to those elicited by Mll1 deletion. Therefore, mature prefrontal neurons critically depend on maintenance of Mll1-regulated H3K4 methylation at a subset of genes with an essential role in cognition and emotion. Copyright © 2015 the authors 0270-6474/15/355097-12$15.00/0.

Los cromosomas mitóticos y meióticos del pez tropical Petenia splendida (Cichlidae

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Lenin Arias-Rodriguez

2008-06-01

Full Text Available Para describir los cromosomas del cariotipo en mitosis y meiosis de la mojarra tenguayaca P. splendida, se procesaron 60 larvas y doce jóvenes (seis hembras y seis machos procedentes de Tabasco, México. Se emplearon los procedimientos citológicos clásicos para peces pequeños y grandes, con algunas modificaciones que permitieron obtener campos cromosómicos en meiosis y mitosis. Analizamos al microscopio 100 laminillas, contando 290 dispersiones cromosómicas. En mitosis, 76.7 % de los conteos dieron número modal diploide de 2N=48 cromosomas, mientras en meiosis el 55.2 % mostró 24 cromosomas en condición haploide. Se analizaron ocho de las mejores fotografías para establecer el cariotipo y se identificaron tres pares de cromosomas birrámeos metacéntricos-submetacéntricos (msm y 21 pares de cromosomas monorrámeos subtelocéntricos-acrocéntricos (sta con número fundamental (N.F de 54 brazos. Se corroboró el cariotipo mediante el análisis de campos cromosómicos en estadio haploide y diploide de la meiosis I. Las dispersiones cromosómicas tuvieron un número mayor en larvas que en jóvenes. No hubo diferencias heteromórficas para distinguir cromosomas sexuales. Sin embargo, se observó la presencia de cuerpos cromáticos en forma de puntos, como una característica propia de los microcromosomas "B". Para esta familia, el cariotipo de P. splendida es primitivo o tipo "A"; y es estrechamente parecido al del género Cichlasoma. El origen de los cromosomas supernumerarios es un fenómeno aun desconocido en los cíclidos por lo que faltan estudios relacionados con el daño causado por la contaminación y la hibridación.The mitotic and meiotic chromosomes of the tropical fish Petenia splendida (Cichlidae. The karyotype of bay snook, Petenia splendida, is described based on mitotic and meiotic stages of sixty larvae and twelve juveniles from Tabasco, Mexico. Standard cytological procedures with minor modifications were followed to obtain mitotic and meiotic chromosome spreads. One hundred chromosome slides were analyzed and 290 chromosome spreads were counted. High-quality spreads in mitosis and meiosis were used for karyotype analysis. Mitotic chromosome spreads showed 76.7 % of such cells with 2n=48 chromosomes, while meiotic spreads revealed 55.2 % with 24 chromosomes in haploid stage. Photographic documentation of eight highquality pictures showed that the karyotype consists of three pairs of bi-armed metacentric-submetacentric chromosomes (msm and 21 pairs with uni-armed subtelocentric-acrocentric chromosomes (sta, with a fundamental number (FN of 54 arms. Karyotype chromosomes were verified by analysis of haploid and diploid metaphases at meiotic stage I. Abundant chromosome spreads were observed more frequently on slides from larvae. No evidence of heteromorphism to discriminate sexual chromosomes was detected. There were "dot-like" chromatic bodies in both sexes and they were classified as "B" chromosomes. The karyotype of P. splendida is type "A", i.e. primitive in the Cichlid family, similar to other species of Cichlasoma. The occurrence of supernumerary chromosomes is still unknown: studies on the effects of pollution and hybridization might be important to understand that phenomenon. Rev. Biol. Trop. 56 (2: 895-907. Epub 2008 June 30.

Membangun Bencana: Tinjauan Kritis atas Peran Negara dalam Kasus Lapindo

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Anton Novenanto

2016-06-01

Full Text Available Artikel ini berangkat dari pernyataan problematik yang dilontarkan Joko ‘Jokowi’ Widodo pada 29 Mei 2014 tentang perlunya negara hadir dalam kasus Lapindo. Pernyataan itu bisa muncul karena asumsi yang berkembang selama ini menyatakan bahwa negara absen dalam kasus Lapindo. Artikel ini muncul untuk mempersoalkan ‘kebenaran’ pernyataan itu. Mengikuti definisi ‘bencana pembangunan’ yang ditawarkan Oliver-Smith, artikel ini hendak menghadirkan bukti-bukti kehadiran negara dalam kasus Lapindo. Argumen artikel ini adalah bencana bukanlah semata peristiwa tapi juga proses, yang dapat diurai dengan menelusuri rerantai agenda politik yang melingkupinya. Normal 0 false false false EN-US JA X-NONE

Les Trente Glorieuses et la crise de 1973

OpenAIRE

Aymard, Maurice

2013-01-01

Il est indispensable de préciser d’entrée de jeu les deux expressions qui composent ce titre, qui m’avait été proposé au printemps 2005 par les organisateurs de la deuxième édition des rencontres de Shanghai (septembre 2005), Duanmu Mei et Jean-Claude Thivolle. 1. Les « Trente Glorieuses » sont la première partie du titre d’un ouvrage de Jean Fourastié, un économiste dont la vie a couvert le xxe siècle (1910-1990), et qui avait bâti son œuvre et sa réputation sur deux directions complémentair...

Hubungan panjang berat dan faktor kondisi ikan gabus (Channa striata Bloch, 1793 yang dibesarkan di rawa lebak, Provinsi Sumatera Selatan

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Dina Muthmainnah

2013-12-01

Full Text Available Penelitian ini bertujuan untuk mengetahui hubungan panjang berat dan faktor kondisi ikan gabus (Channa striata telah dipelihara di rawa lebak Sekayu Kabupaten Musi Banyuasin dan Mariana Kabupaten Banyuasin Provinsi Sumatera Selatan pada Mei hingga November 2013. Hasil penelitian menunjukkan hubungan panjang berat tidak menunjukkan perbedaan nyata antara rawa Sekayu dan Mariana dengan nilai b di bawah nilai 3 yang berarti pertumbuhan ikan gabus tersebut allometrik negatif. Ikan gabus yang dipelihara di rawa lebak Mariana menghasilkan faktor kondisi 0,884 lebih tinggi daripada di rawa lebak Sekayu 0,839, yang menunjukkan bahwa kondisi lingkungan rawa lebak Mariana lebih mendukung untuk pertumbuhan ikan gabus.

Radiological NESHAP ANNUAL REPORT CY 2016.

Energy Technology Data Exchange (ETDEWEB)

Evelo, Stacie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-06-01

This report provides a summary of the radionuclide releases from the United States (U.S.) Department of Energy (DOE) National Nuclear Security Administration facilities at Sandia National Laboratories, New Mexico (SNL/NM) during Calendar Year (CY) 2016, including the data, calculations, and supporting documentation for demonstrating compliance with 40 Code of Federal Regulation (CFR) 61, Subpart H--NATIONAL EMISSION STANDARDS FOR EMISSIONS OF RADIONUCLIDES OTHER THAN RADON FROM DEPARTMENT OF ENERGY FACILITIES (Radiological NESHAP). A description is given of the sources and their contributions to the overall dose assessment. In addition, the maximally exposed individual (MEI) radiological dose calculation and the population dose to local and regional residents are discussed.

PENGARUH STRATEGI PEMBELAJARAN BIOLOGY ENVIRONMENT TECHNOLOGY SOCIETY (BETS TERHADAP KEMAMPUAN BERPIKIR KRITIS DAN HASIL BELAJAR BIOLOGI KELAS X KOTA MALANG

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Eka Arum Sasi Mahardika

2016-08-01

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran BETS terhadap kemampuan berpikir kritis dan hasil belajar biologi  kelas X SMA Kota Malang. Penelitian ini dilaksanakan di SMAN 7 Malang pada bulan Februari-Mei 2016. Kemampuan berpikir kritis dan hasil belajar kognitif diukur melalui tes tulis sedangkan ranah afektif dan psikomor diukur melalui observasi selama pembelajaran. Data kemampuan berpikir kritis dan hasil belajar kognitif dianalisis menggunakan uji statistik dengan bantuan Software SPSS 22.0 for Window. Hasil penelitian menunjukkan bahwa ada pengaruh strategi BETS terhadap kemampuan berpikir kritis dan hasil belajar kognitif; afektif kelas eksperimen lebih tinggi dibandingkan kelas kontrol; psikomotor kelas kontrol lebih tinggi dibandingkan kelas kontrol.

Analysing, Interpreting, and Testing the Invariance of the Actor-Partner Interdependence Model

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Gareau, Alexandre

2016-09-01

Full Text Available Although in recent years researchers have begun to utilize dyadic data analyses such as the actor-partner interdependence model (APIM, certain limitations to the applicability of these models still exist. Given the complexity of APIMs, most researchers will often use observed scores to estimate the model's parameters, which can significantly limit and underestimate statistical results. The aim of this article is to highlight the importance of conducting a confirmatory factor analysis (CFA of equivalent constructs between dyad members (i.e. measurement equivalence/invariance; ME/I. Different steps for merging CFA and APIM procedures will be detailed in order to shed light on new and integrative methods.

Hurricane feedback research may improve intensity forecasts

Science.gov (United States)

Schultz, Colin

2012-06-01

Forecasts of a hurricane's intensity are generally much less accurate than forecasts of its most likely path. Large-scale atmospheric patterns dictate where a hurricane will go and how quickly it will get there. The storm's intensity, however, depends on small-scale shifts in atmospheric stratification, upwelling rates, and other transient dynamics that are difficult to predict. Properly understanding the risk posed by an impending storm depends on having a firm grasp of all three properties: translational speed, intensity, and path. Drawing on 40 years of hurricane records representing 3090 different storms, Mei et al. propose that a hurricane's translational speed and intensity may be closely linked.

The functional and structural characteristics of the emotion network in alexithymia

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Han D

2018-04-01

Full Text Available Dai Han,1–3 Mei Li,4 Minjun Mei,4 Xiaofei Sun4 1Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China; 2Children and Adolescents Mental Health Joint Clinic, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China; 3Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, China; 4Mental Health Education and Counseling Center, Hangzhou Normal University, Hangzhou, Zhejiang, China Background: Alexithymia is a multifaceted personality trait characterized by emotional dysfunction.Methods: In this study, the functional and structural features of the emotion network in alexithymia were investigated using resting-state functional MRI (rsfMRI, voxel-based morphometry (VBM, functional connectivity (FC analysis, and diffusion tensor imaging (DTI. Alexithymic and non-alexithymic students were recruited from the local university. The intrinsic neural activity and gray matter density of the brain regions in the emotion network were measured using rsfMRI and VBM; the FC and structural connectivity of the brain regions in the emotion network were measured using FC analysis and DTI.Results: The altered intrinsic neural activity in V1, rostral dorsal anterior cingulate cortex, and left amygdala, and the weak FC between V1 and left superior temporal gyrus and V1 and left paracentral lobule in alexithymia subjects were identified. However, no alteration of the structure and structural connectivity of the emotion network was identified.Conclusion: The results indicated that the development of alexithymia might have been caused only by slight alteration of the neural activity. Furthermore, the results suggest that noninvasive treatment technologies for improving the brain activity are suitable for alexithymic individuals. Keywords: emotion network, rsfMRI, VBM, functional connectivity, structural connectivity

Damage accumulation and dopant migration during shallow As and Sb implantation into Si

Energy Technology Data Exchange (ETDEWEB)

Werner, M.; Berg, J.A. van den E-mail: j.a.vandenberg@salford.ac.uk; Armour, D.G.; Vandervorst, W.; Collart, E.H.J.; Goldberg, R.D.; Bailey, P.; Noakes, T.C.Q

2004-02-01

The damage evolution and concomitant dopant redistribution as a function of ion fluence during ultra shallow, heavy ion implants into Si have been investigated using medium energy ion scattering (MEIS) and secondary ion mass spectrometry (SIMS). These studies involved As and Sb ions implanted at room temperature, at energies of 2.5 and 2 keV to doses from 3 x 10{sup 13} to 5 x 10{sup 15} cm{sup -2}. MEIS is capable of detecting both the displaced atom and implant profiles with sub-nanometre depth resolution. These studies show that for doses up to 1 x 10{sup 14} cm{sup -2} (at which an amorphous layer is formed) the damage build up does not follow the energy deposition function. Instead it proceeds through the initial formation of a {approx}4 nm wide amorphous layer immediately under the oxide, that grows inwards into the bulk with increasing dose. This behaviour is explained in terms of the migration of some of the interstitials produced along the length of the collision cascade to the oxide or amorphous/crystal Si interface, where their trapping nucleates the growth of a shallow amorphous layer and the subsequent planar growth inwards of the damage layer. Although for doses {>=}4 x 10{sup 14} cm{sup -2} the As depth profiles agreed well with TRIM calculations, for lower doses As was observed to have a shallower profile, {approx}2 nm nearer to the surface. This behaviour is related the growth of the amorphous layer and ascribed to the movement of As into the near-surface amorphous layer (probably mediated by point defect migration) in which the larger dopant is accommodated more easily. SIMS studies have confirmed this dopant segregation effect. Shallow Sb implants also exhibit this novel dopant movement effect for low doses in combination with a damage evolution similar to As.

Damage accumulation and dopant migration during shallow As and Sb implantation into Si

International Nuclear Information System (INIS)

Werner, M.; Berg, J.A. van den; Armour, D.G.; Vandervorst, W.; Collart, E.H.J.; Goldberg, R.D.; Bailey, P.; Noakes, T.C.Q.

2004-01-01

The damage evolution and concomitant dopant redistribution as a function of ion fluence during ultra shallow, heavy ion implants into Si have been investigated using medium energy ion scattering (MEIS) and secondary ion mass spectrometry (SIMS). These studies involved As and Sb ions implanted at room temperature, at energies of 2.5 and 2 keV to doses from 3 x 10 13 to 5 x 10 15 cm -2 . MEIS is capable of detecting both the displaced atom and implant profiles with sub-nanometre depth resolution. These studies show that for doses up to 1 x 10 14 cm -2 (at which an amorphous layer is formed) the damage build up does not follow the energy deposition function. Instead it proceeds through the initial formation of a ∼4 nm wide amorphous layer immediately under the oxide, that grows inwards into the bulk with increasing dose. This behaviour is explained in terms of the migration of some of the interstitials produced along the length of the collision cascade to the oxide or amorphous/crystal Si interface, where their trapping nucleates the growth of a shallow amorphous layer and the subsequent planar growth inwards of the damage layer. Although for doses ≥4 x 10 14 cm -2 the As depth profiles agreed well with TRIM calculations, for lower doses As was observed to have a shallower profile, ∼2 nm nearer to the surface. This behaviour is related the growth of the amorphous layer and ascribed to the movement of As into the near-surface amorphous layer (probably mediated by point defect migration) in which the larger dopant is accommodated more easily. SIMS studies have confirmed this dopant segregation effect. Shallow Sb implants also exhibit this novel dopant movement effect for low doses in combination with a damage evolution similar to As

Model Interpretation of Climate Signals: Application to the Asian Monsoon Climate

Science.gov (United States)

Lau, William K. M.

2002-01-01

This is an invited review paper intended to be published as a Chapter in a book entitled "The Global Climate System: Patterns, Processes and Teleconnections" Cambridge University Press. The author begins with an introduction followed by a primer of climate models, including a description of various modeling strategies and methodologies used for climate diagnostics and predictability studies. Results from the CLIVAR Monsoon Model Intercomparison Project (MMIP) were used to illustrate the application of the strategies to modeling the Asian monsoon. It is shown that state-of-the art atmospheric GCMs have reasonable capability in simulating the seasonal mean large scale monsoon circulation, and response to El Nino. However, most models fail to capture the climatological as well as interannual anomalies of regional scale features of the Asian monsoon. These include in general over-estimating the intensity and/or misplacing the locations of the monsoon convection over the Bay of Bengal, and the zones of heavy rainfall near steep topography of the Indian subcontinent, Indonesia, and Indo-China and the Philippines. The intensity of convection in the equatorial Indian Ocean is generally weaker in models compared to observations. Most important, an endemic problem in all models is the weakness and the lack of definition of the Mei-yu rainbelt of the East Asia, in particular the part of the Mei-yu rainbelt over the East China Sea and southern Japan are under-represented. All models seem to possess certain amount of intraseasonal variability, but the monsoon transitions, such as the onset and breaks are less defined compared with the observed. Evidences are provided that a better simulation of the annual cycle and intraseasonal variability is a pre-requisite for better simulation and better prediction of interannual anomalies.

Dose assessment from potential radionuclide emissions from stacks on the Hanford Site

International Nuclear Information System (INIS)

Davis, W.E.; Barnett, J.M.

1995-04-01

On February 3, 1993, the US Department of Energy, Richland Operations Office (RL), received a Compliance Order and Information Request from the Director of the Air and Toxics Division of the US Environmental Protection Agency (EPA), Region 10. The Compliance Order required RL to (1) evaluate all radionuclide emission points at the Hanford Site to determine which points are subject to the continuous emission sampling requirements of Title 40, Code of Federal Regulations, Part 61 (40 CFR 61), Subpart H, and (2) continuously sample radionuclide emissions in accordance with requirements in 40 CFR 61.93. The Information Request required RL to provide a written Compliance Plan to meet the requirements of the Compliance Order. A Compliance Plan was submitted to EPA, Region 10, on April 30, 1993. The Compliance Plan specified that a dose assessment would be performed for 84 Westinghouse Hanford Company (WHC) stacks registered with the Washington State Department of Health on the Hanford Site. Any stack identified in the assessment as having potential emissions to cause an effective dose equivalent (EDE) to a maximum exposed individual (MEI) greater than 0.1 mrem y -1 must have a compliant sampling system. In addition, a Federal Facility Compliance Agreement (FFCA) was signed on. February 7, 1994. The FFCA required that all unregistered stacks on the Hanford Site be assessed. This requirement increased the number of stacks to be assessed to 123 stacks. Six methods for performing the assessments are described. An initial assessment using only the HEPA filtration factor for back calculations identified 32 stacks that would have emissions which would cause an EDE to the MEI greater than 0.1 mrem y -1 . When the other methods were applied the number was reduced to 20 stacks. The paper discusses reasons for these overestimates

Long-term (1993-2013) changes in macrozooplankton off the Western Antarctic Peninsula

Science.gov (United States)

Steinberg, Deborah K.; Ruck, Kate E.; Gleiber, Miram R.; Garzio, Lori M.; Cope, Joseph S.; Bernard, Kim S.; Stammerjohn, Sharon E.; Schofield, Oscar M. E.; Quetin, Langdon B.; Ross, Robin M.

2015-07-01

The Western Antarctic Peninsula (WAP) is one of the most rapidly warming regions on Earth, and where a high apex predator biomass is supported in large part by macrozooplankton. We examined trends in summer (January-February) abundance of major taxa of macrozooplankton along the WAP over two decades (1993-2013) and their relationship with environmental parameters (sea ice, atmospheric climate indices, sea surface temperature, and phytoplankton biomass and productivity). Macrozooplankton were collected from the top 120 m of the water column in a mid-Peninsula study region divided into latitudinal (North, South, and Far South) and cross-shelf (coastal, shelf, slope) sub-regions. Trends for krill species included a 5-year cycle in abundance peaks (positive anomalies) for Euphausia superba, but no directional long-term trend, and an increase in Thysanoessa macrura in the North; variability in both species was strongly influenced by primary production 2-years prior. E. crystallorophias abundance was best explained by the Southern Annular Mode (SAM) and Multivariate El Niño Southern Oscillation Index (MEI), and was more abundant in higher ice conditions. The salp Salpa thompsoni and thecosome pteropod Limacina helicina cycled between negative and positive anomalies in the North, but showed increasing positive anomalies in the South over time. Variation in salp and pteropod abundance was best explained by SAM and the MEI, respectively, and both species were more abundant in lower ice conditions. There was a long-term increase in some carnivorous gelatinous zooplankton (polychaete worm Tomopteris spp.) and amphipods. Abundance of Pseudosagitta spp. chaetognaths was closely related to SAM, with higher abundance tied to lower ice conditions. Long-term changes and sub-decadal cycles of WAP macrozooplankton community composition may affect energy transfer to higher trophic levels, and alter biogeochemical cycling in this seasonally productive and sensitive polar ecosystem.

Caterpillar MorElectric DOE Idle Reduction Demonstration Program

Energy Technology Data Exchange (ETDEWEB)

John Bernardi

2007-09-30

This project titled 'Demonstration of the New MorElectric{trademark} Technology as an Idle Reduction Solution' is one of four demonstration projects awarded by the US Department of Energy in 2002. The goal of these demonstration and evaluation projects was to gather objective in-use information on the performance of available idle reduction technologies by characterizing the cost; fuel, maintenance, and engine life savings; payback; and user impressions of various systems and techniques. In brief, the Caterpillar Inc. project involved applying electrically driven accessories for cab comfort during engine-off stops and for reducing fuel consumption during on-highway operation. Caterpillar had equipped and operated five new trucks with the technology in conjunction with International Truck and Engine Corporation and COX Transfer. The most significant result of the project was a demonstrated average idle reduction of 13.8% for the 5 truck MEI fleet over the control fleet. It should be noted that the control fleet trucks were also equipped with an idle reduction device that would start and stop the main engine automatically in order to maintain cab temperature. The control fleet idle usage would have been reduced by 3858 hours over the 2 year period with the MEI system installed, or approximately 2315 gallons of fuel less (calculations assume a fuel consumption of 0.6 gallons per hour for the 13 liter engine at idle). The fuel saved will be significantly larger for higher displacement engines without idle reduction equipment such as the engine auto start/stop device used by COX Transfer. It is common for engines to consume 1.0 gallons per hour which would increase the fuel savings to approximately 1260 gallons per truck per year of typical idling (1800 hours idle/yr).

Quantitation of 13 heterocyclic aromatic amines in cooked beef, pork, and chicken by liquid chromatography-electrospray ionization/tandem mass spectrometry.

Science.gov (United States)

Ni, Weijuan; McNaughton, Lynn; LeMaster, David M; Sinha, Rashmi; Turesky, Robert J

2008-01-09

The concentrations of heterocyclic aromatic amines (HAAs) were determined, by liquid chromatography-electrospray ionization/tandem mass spectrometry (LC-ESI-MS/MS), in 26 samples of beef, pork, and chicken cooked to various levels of doneness. The HAAs identified were 2-amino-3-methylimidazo[4,5- f]quinoline, 2-amino-1-methylimidazo[4,5- b]quinoline, 2-amino-1-methylimidazo[4,5- g]quinoxaline (I gQx), 2-amino-3-methylimidazo[4,5- f]quinoxaline, 2-amino-1,7-dimethylimidazo[4,5- g]quinoxaline (7-MeI gQx), 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline, 2-amino-1,6-dimethyl-furo[3,2- e]imidazo[4,5- b]pyridine, 2-amino-1,6,7-trimethylimidazo[4,5- g]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5- f]quinoxaline, 2-amino-1,7,9-trimethylimidazo[4,5- g]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP), 2-amino-9 H-pyrido[2,3- b]indole, and 2-amino-3-methyl-9 H-pyrido[2,3- b]indole. The concentrations of these compounds ranged from chicken (up to 305 microg/kg), broiled bacon (16 microg/kg), and pan-fried bacon (4.9 microg/kg). 7-MeI gQx was the most abundant HAA formed in very well done pan-fried beef and steak, and in beef gravy, at concentrations up to 30 microg/kg. Several other linear tricyclic ring HAAs containing the I gQx skeleton are formed at concentrations in cooked meats that are relatively high in comparison to the concentrations of their angular tricyclic ring isomers, the latter of which are known experimental animal carcinogens and potential human carcinogens. The toxicological properties of these recently discovered I gQx derivatives warrant further investigation and assessment.

A Simple Predictive Enhancer Syntax for Hindbrain Patterning Is Conserved in Vertebrate Genomes.

Directory of Open Access Journals (Sweden)

Joseph Grice

Full Text Available Determining the function of regulatory elements is fundamental for our understanding of development, disease and evolution. However, the sequence features that mediate these functions are often unclear and the prediction of tissue-specific expression patterns from sequence alone is non-trivial. Previous functional studies have demonstrated a link between PBX-HOX and MEIS/PREP binding interactions and hindbrain enhancer activity, but the defining grammar of these sites, if any exists, has remained elusive.Here, we identify a shared sequence signature (syntax within a heterogeneous set of conserved vertebrate hindbrain enhancers composed of spatially co-occurring PBX-HOX and MEIS/PREP transcription factor binding motifs. We use this syntax to accurately predict hindbrain enhancers in 89% of cases (67/75 predicted elements from a set of conserved non-coding elements (CNEs. Furthermore, mutagenesis of the sites abolishes activity or generates ectopic expression, demonstrating their requirement for segmentally restricted enhancer activity in the hindbrain. We refine and use our syntax to predict over 3,000 hindbrain enhancers across the human genome. These sequences tend to be located near developmental transcription factors and are enriched in known hindbrain activating elements, demonstrating the predictive power of this simple model.Our findings support the theory that hundreds of CNEs, and perhaps thousands of regions across the human genome, function to coordinate gene expression in the developing hindbrain. We speculate that deeply conserved sequences of this kind contributed to the co-option of new genes into the hindbrain gene regulatory network during early vertebrate evolution by linking patterns of hox expression to downstream genes involved in segmentation and patterning, and evolutionarily newer instances may have continued to contribute to lineage-specific elaboration of the hindbrain.

Engineering of lipid prodrug-based, hyaluronic acid-decorated nanostructured lipid carriers platform for 5-fluorouracil and cisplatin combination gastric cancer therapy

Directory of Open Access Journals (Sweden)

Qu CY

2015-06-01

Full Text Available Chun-Ying Qu,1,* Min Zhou,1,* Ying-wei Chen,2 Mei-mei Chen,3 Feng Shen,1 Lei-Ming Xu11Digestive Endoscopic Diagnosis and Treatment Center, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, People’s Republic of China; 3Digestive Department, Xinhua Hospital, School of medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China*These authors contributed equally to this workPurpose: The first-line chemotherapy treatment protocol for gastric cancer is combination chemotherapy of 5-fluorouracil (5-FU and cisplatin (CDDP. The aim of this study was to engineer prodrug-based nanostructured lipid carriers (NLC platform for codelivery of 5-FU and CDDP to enhance therapy and decrease toxicity.Methods: First, 5-FU-stearic acid lipid conjugate was synthesized by two steps. Second, 5-FU-stearic acid prodrug and CDDP were loaded in NLC. Finally, hyaluronic acid (HA was coated onto NLC surface. Average size, zeta potential, and drug loading capacity of NLC were evaluated. Human gastric cancer cell line BGC823 (BGC823 cells was used for the testing of in vitro cytotoxicity assays. In vivo antitumor activity of NLC was evaluated in mice bearing BGC823 cells model.Results: HA-coated 5-FU-stearic acid prodrug and CDDP-loaded NLC (HA-FU/C-NLC showed a synergistic effect in combination therapy and displayed the greatest antitumor activity than all of the free drugs or uncoated NLC in vitro and in vivo.Conclusion: This work reveals that HA-coated NLC could be used as a novel carrier to codeliver 5-FU and CDDP for gastric cancer therapy. HA-FU/C-NLC could be a promising targeted and combinational therapy in nanomedicine.Keywords: gastric cancer, nanostructured lipid carriers, hyaluronic acid, combination chemotherapy, lipid prodrug

DEFORMITAS LIGULA LARVA TANYPODINAE SEBAGAI INDIKATOR PENCEMARAN LOGAM BERAT DI DANAU LIDO, JAWA BARAT

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Tyas Dita Pramesthy

2014-08-01

Full Text Available As one group of Chironomidae Tanypodinae larvae can be used in biological assessment to detect the heavymetal pollution in aquatic environment, because they could show morphological changes due to the pollution. Thestudy was aimed to describe ligula deformities in Tanypodinae larvae in a heavy metal polluted lake. The study wasconducted in Mei to June 2014 at Lake Lido, West Java. The results showed that lead (Pb concentration in LidoLake was quaite high, i.e. 0.08 0.19 mg/L. Ten of fifty-five collected Tanypodinae larve exhibited deformation in theirligulae. Index of severity of ligula deformation (ILSD was 4.4 indicating the response of the Chironomidae larvae tolead pollution.

Prediksi Jumlah Tamu Menginap di Hotel Karlita International, Tegal, Jawa Tengah

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Haryadi Sarjono

2013-11-01

Full Text Available Article is forecasting comparative analysis of number of guess room occupancy at Karlita International Hotel, Tegal, Central Java using 11 forecasting methods: linear regression, moving average, weighted moving average, exponential smoothing, exponential smoothing with trend, naïve method, trend analysis, additive decomposition – CMA, additive decomposition – average all, multiplicative decomposition – CMA, multiplicative decomposition – average All. Article used 17 data from January 2012 to Mei 2013, and results after using those 11 methods were the smallest MAD is 101.69 and the smallest MSE is 15,163.95. From additive decomposition – average all method, data showed guess room occupancy forecast at Karlita International Hotel for June 2013 is 960 guess.

Marine Sciences Laboratory Radionuclide Air Emissions Report for Calendar Year 2015

Energy Technology Data Exchange (ETDEWEB)

Snyder, Sandra F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Barnett, J. Matthew [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2016-05-05

The U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest Site Office has oversight and stewardship duties associated with the Pacific Northwest National Laboratory Marine Sciences Laboratory located on Battelle Land – Sequim. This report is prepared to document compliance with the 40 CFR Part 61, Subpart H, “National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities” and Washington Administrative Code . The EDE to the MSL MEI due to routine operations in 2015 was 1.1E-04 mrem (1.1E-06 mSv). No non-routine emissions occurred in 2015. The MSL is in compliance with the federal and state 10 mrem/yr standard.

Eesti teatri aastaauhinnad 2006. aasta loomingu eest

Index Scriptorium Estoniae

2007-01-01

Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind

Eesti teatri aastaauhinnad 2006

Index Scriptorium Estoniae

2007-01-01

Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind

Evidence for cell-replacement repair of X-ray-induced teratogenic damage in male genital imaginal discs of Drosophila melanogaster

International Nuclear Information System (INIS)

Fukunaga, Akihiro; Kondo, Sohei

1985-01-01

Male genital imaginal discs from old (late-third-instar) larvae of Drosophila that had been X-irradiated with appropriate doses developed into severely damaged adult genitalia when implanted into old larvae, but they developed into completely normal adult genitalia when transplanted into 2-day-younger larvae. Complete repair of X-ray-induced teratogenic damage in the genital discs on transplantation into young host larvae was similar in the wild-type and mei-9sup(a) strains. The results are discussed in relation to the hypothesis that repair of X-ray-induced teratogenic damage depends not on DNA repair but on replacement of damage-bearing primordial cells by healthy ones after suicidal elimination of the former. (Auth.)

The bricoleur’s figure in artistic practices

Directory of Open Access Journals (Sweden)

Mariana Resende Côrrea

2014-12-01

Full Text Available Art as process and reflection of the lived moment deals many times with issues that refers to its context and with the available materials in the current scenario. In a society marked by consumption and ephemerality, this article promotes a reflection on the use of disposed and collected products in works of visual artists. The bricoleur appears in this context as a central figure for the understanding and the analysis of some of the many artistic practices realized recently. By bricolage, artists like Joseph Cornell, Farnese de Andrade, Amanda Mei and Courtney Smith performed works with hybrid content that reflect the lived moment and issues contained in the materials available in the current scenario.

Teatri aastaauhindade laureaadid 2008

Index Scriptorium Estoniae

2008-01-01

Tiit Ojasoo - lavastajaauhind, Silver Vahtre, Krista Tool ja Margus Vaigur - kunstniku auhind, Piret Laurimaa - naisnäitleja auhind, Üllar Saaremäe - meesnäitleja auhind, Tiina Tauraite - naiskõrvalosa auhind, Taavi Teplenkov - meeskõrvalosa auhind, Mart Koldits - sõnalavastuse eriauhind, Dmitri Bertman ja Mart Madiste - muusikalavastuse auhind, Vitali Nikolajev - muusikalavastuse eriauhind, Marina Kesler - balletilavastuse auhind, Oksana Titova - tantsulavastuse auhind, Ivika Sillar - kriitikaauhind, Külli Teetamm ja Tambet Tuisk - Ants Lauteri näitlejaauhind, Heli Veskus - Georg Otsa auhind, Finn Poulsen - Salme Reegi auhind, Elo Soode - Natalie Mei auhind, Aarne Üksküla - Priit Põldroosi auhind, Maimu Berg - Aleksander Kurtna auhind, Laura Peterson - Kristallkingakese auhind, Liina Laigu, Kaido Päästel ja Juhan Rumm - teatritöötaja auhind

Eesti teatri aastaauhinnad 2007

Index Scriptorium Estoniae

2008-01-01

Tiit Ojasoo - lavastajaauhind, Silver Vahtre, Krista Tool ja Margus Vaigur - kunstniku auhind, Piret Laurimaa - naisnäitleja auhind, Üllar Saaremäe - meesnäitleja auhind, Tiina Tauraite - naiskõrvalosa auhind, Taavi Teplenkov - meeskõrvalosa auhind, Mart Koldits - sõnalavastuse eriauhind, Dmitri Bertman ja Mart Madiste - muusikalavastuse auhind, Vitali Nikolajev - muusikalavastuse eriauhind, Marina Kesler - balletilavastuse auhind, Oksana Titova - tantsulavastuse auhind, Ivika Sillar - kriitikaauhind, Külli Teetamm ja Tambet Tuisk - Ants Lauteri näitlejaauhind, Heli Veskus - Georg Otsa auhind, Finn Poulsen - Salme Reegi auhind, Elo Soode - Natalie Mei auhind, Aarne Üksküla - Priit Põldroosi auhind, Maimu Berg - Aleksander Kurtna auhind, Laura Peterson - Kristallkingakese auhind, Liina Laigu, Kaido Päästel ja Juhan Rumm - teatritöötaja auhind

TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

DEFF Research Database (Denmark)

Willer, Anton; Jakobsen, Janus Schou; Ohlsson, E

2015-01-01

orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute myeloid leukemia (AML). TGIF1/TGIF2 are relatively uncharacterized TALE transcription factors, which, in contrast to the remaining family, have been shown to act as transcriptional repressors. Given the general......Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which...... influence the clinical outcome. Collectively, these findings demonstrate that TALE family members can act both positively and negatively on transcriptional programs responsible for leukemic maintenance and provide novel insights into the regulatory gene expression circuitries in MLL-rearranged AML.Leukemia...

Radioactive Air Emissions Notice of Construction (NOC) Application for the Waste Sampling and Characterization Facility (WSCF)

International Nuclear Information System (INIS)

BATES, J.A.

2000-01-01

This NOC application is provided to update the description of amounts of material handled, and to update the calculation of potential for emissions and resultant calculation of offsite TEDE. This NOC also includes an updated description of the various emission units at WSCF, including use of portable tanks to receive and remove liquid waste contaminated with low levels of radioactive contamination. The resultant, adjusted estimate for TEDE to the hypothetical MEI due to all combined unabated emissions from WSCF is 1.4 E-02 millirem per year. The total adjusted estimate for all combined abated emissions is 2.8 E-03 millirem per year. No single emission unit at the WSCF Complex exceeds a potential (unabated) offsite dose of 2.7 E-03 millirem per year

Energy from the Japanese Sea; Energie uit de Japanse zee

Energy Technology Data Exchange (ETDEWEB)

Stroeks, R.

2012-06-29

May 2012 the Japanese government announced a policy for the promotion of renewable energy in the ocean. The action plan consists of setting up a demonstration and test facility in the open sea. For 2012, a feasibility study is planned and suitable locations for the test facility will be examined. From 2013 on, the construction of the facility will be started and promoted [Dutch] Mei2012 kondigde de Japanse overheid een beleid voor de promotie van ocean renewable energy aan. Het actieplan bestaat uit het opzetten van een demonstratie- en testfaciliteit op open zee. Voor 2012 staat een haalbaarheidsstudie gepland en zullen er geschikte locaties voor de testfaciliteit worden onderzocht. Vanaf 2013 moet de bouw van de faciliteit beginnen en moet de promotie verder vorm krijgen.

Simple national : a change of tax vision for individual microenterprise microenterprise . study on entrepreneurship in gardening sector in the municipality of são paulo

Directory of Open Access Journals (Sweden)

Windsor Espenser Veiga

2016-06-01

Full Text Available The constant changes in the Brazilian economy have favored several alternatives, including the gardening sector, making it an attractive option for entrepreneurs . This study aims to analyze what the tax impact on the migration framework of MEI - Single Microempreendedor for Microenterprise , in providing gardening services in Sao Paulo. At the end of the study it was found that the migration of the tax framework represented financial impacts to the increase in tax expenses , and also brought significant impacts and costs in accounting management control of companies. Considering the complexity of the issue and the constant changes in the taxes law, this study does not intend not exhaust the subject, but to present an insight into the tax impact depending on the business environment.