Scientific Infrastructure To Support Manned And Unmanned Aircraft, Tethered Balloons, And Related Aerial Activities At Doe Arm Facilities On The North Slope Of Alaska

Science.gov (United States)

Ivey, M.; Dexheimer, D.; Hardesty, J.; Lucero, D. A.; Helsel, F.

2015-12-01

The U.S. Department of Energy (DOE), through its scientific user facility, the Atmospheric Radiation Measurement (ARM) facilities, provides scientific infrastructure and data to the international Arctic research community via its research sites located on the North Slope of Alaska. DOE has recently invested in improvements to facilities and infrastructure to support operations of unmanned aerial systems for science missions in the Arctic and North Slope of Alaska. A new ground facility, the Third ARM Mobile Facility, was installed at Oliktok Point Alaska in 2013. Tethered instrumented balloons were used to make measurements of clouds in the boundary layer including mixed-phase clouds. A new Special Use Airspace was granted to DOE in 2015 to support science missions in international airspace in the Arctic. Warning Area W-220 is managed by Sandia National Laboratories for DOE Office of Science/BER. W-220 was successfully used for the first time in July 2015 in conjunction with Restricted Area R-2204 and a connecting Altitude Reservation Corridor (ALTRV) to permit unmanned aircraft to operate north of Oliktok Point. Small unmanned aircraft (DataHawks) and tethered balloons were flown at Oliktok during the summer and fall of 2015. This poster will discuss how principal investigators may apply for use of these Special Use Airspaces, acquire data from the Third ARM Mobile Facility, or bring their own instrumentation for deployment at Oliktok Point, Alaska. The printed poster will include the standard DOE funding statement.

Annoyance by aircraft noise and fear of overflying aircraft in relation to attitudes toward the environment and community

Science.gov (United States)

Loeb, M.; Moran, S. V.

1977-01-01

It has been suggested that expressions of annoyance attributable to aircraft noise may reflect in part fear of aircraft overflights and possible crashes. If this is true, then residents of areas where crashes have occurred should express more annoyance. To test this hypothesis, 50 residents of an Albany, New York area where an aircraft crash producing fatalities recently occurred and 50 residents of a comparable nearby area without such a history, were asked to respond to a 'Quality of Life Questionnaire.' Among the items were some designed to test annoyance by noise and fear of aircraft overflights. It was predicted that those in the crash area would express more fear and would more often identify aircraft as a noise source. These hypotheses were sustained. A near-replication was carried out in Louisville, Kentucky; results were much the same. Analyses indicated that for the crash-area groups, there was associating of aircraft fear and noise annoyance responses; this was true to an apparently lesser extent for non-crash groups. The greater annoyance of crash groups by aircraft community noise apparently does not carry over to situations in which aircraft noise is assessed in the laboratory.

14 CFR 39.5 - When does FAA issue airworthiness directives?

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false When does FAA issue airworthiness directives? 39.5 Section 39.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS DIRECTIVES § 39.5 When does FAA issue airworthiness directives? FAA issues...

Standard Test Method to Determine Color Change and Staining Caused by Aircraft Maintenance Chemicals upon Aircraft Cabin Interior Hard Surfaces

CERN Document Server

American Society for Testing and Materials. Philadelphia

2001-01-01

1.1 This test method covers the determination of color change and staining from liquid solutions, such as cleaning or disinfecting chemicals or both, on painted metallic surfaces and nonmetallic surfaces of materials being used inside the aircraft cabin. The effects upon the exposed specimens are measured with the AATCC Gray Scale for Color Change and AATCC Gray Color Scale for Staining. Note 1—This test method is applicable to any colored nonmetallic hard surface in contact with liquids. The selected test specimens are chosen because these materials are present in the majority of aircraft cabin interiors. 1.2This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

NDI (Nondestructive Inspection) Oriented Corrosion Control for Army Aircraft. Phase 1. Inspection Methods

Science.gov (United States)

1989-07-01

Appendices A and B and are provided as cover sheets from each item rather than completc packages. The Pamplet Series materials were furnished as camera-ready...34Stational Neutron Radiography System for Aircraft Reliability and Maintainability." G. A. Technologies Brochure , Triga Reactor Division, San Diego

Sr and Pb isotopic composition of five USGS glasses (BHVO-2G, BIR-1G, BCR-2G, TB-1G, NKT-1G)

NARCIS (Netherlands)

Elburg, M.A.; Vroon, P.Z.; van der Wagt, R.A.C.A.; Tchalikian, A.

2005-01-01

Sr isotopic compositions and Rb/Sr ratios of three USGS glasses (BHVO-2G, BIR-1G, BCR-2G) are identical to those of the original USGS reference materials. NKT-1G and TB-1G give values of 0.70351 and 0.70558, respectively. Pb isotopic ratios were measured by the standard-sample bracketing technique

14 CFR 21.6 - Manufacture of new aircraft, aircraft engines, and propellers.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Manufacture of new aircraft, aircraft... Manufacture of new aircraft, aircraft engines, and propellers. (a) Except as specified in paragraphs (b) and (c) of this section, no person may manufacture a new aircraft, aircraft engine, or propeller based on...

Adaptive and Online Health Monitoring System for Autonomous Aircraft

OpenAIRE

Mokhtar, Maizura; Zapatel-Bayo, Sergio Z.; Hussein, Saed; Howe, Joe M.

2012-01-01

Good situation awareness is one of the key attributes required to maintain safe flight, especially for an Unmanned Aerial System (UAS). Good situation awareness can be achieved by incorporating an Adaptive Health Monitoring System (AHMS) to the aircraft. The AHMS monitors the flight outcome or flight behaviours of the aircraft based on its external environmental conditions and the behaviour of its internal systems. The AHMS does this by associating a health value to the aircraft's behaviour b...

Estimate of aircraft crash hit frequencies on to facilities at the Lawrence Livermore National Laboratory (LLNL) Site 200

International Nuclear Information System (INIS)

Kimura, C.Y.

1997-01-01

Department of Energy (DOE) nuclear facilities are required by DOE Order 5480.23, Section 8.b.(3)(k) to consider external events as initiating events to accidents within the scope of their Safety Analysis Reports (SAR). One of the external initiating events which should be considered within the scope of a SAR is an aircraft accident, i.e., an aircraft crashing into the nuclear facility with the related impact and fire leading to penetration of the facility and to the release of radioactive and/or hazardous materials. This report presents the results of an Aircraft Crash Frequency analysis performed for the Materials Management Area (MMA), and the National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL) Site 200. The analysis estimates only the aircraft crash hit frequency on to the analyzed facilities. No initial aircraft crash hit frequency screening structural response calculations of the facilities to the aircraft impact, or consequence analysis of radioactive/hazardous materials released following the aircraft impact are performed. The method used to estimate the aircraft crash hit frequencies on to facilities at the Lawrence Livermore National Laboratory (LLNL) generally follows the procedure given by the DOE Standard 3014-96 on Aircraft Crash Analysis. However, certain adjustments were made to the DOE Standard procedure because of the site specific fight environment or because of facility specific characteristics

Analysis of Asymmetric Aircraft Aerodynamics Due to an Experimental Wing Glove

Science.gov (United States)

Hartshorn, Fletcher

2011-01-01

Aerodynamic analysis on a business jet with a wing glove attached to one wing is presented and discussed. If a wing glove is placed over a portion of one wing, there will be asymmetries in the aircraft as well as overall changes in the forces and moments acting on the aircraft. These changes, referred to as deltas, need to be determined and quantified to make sure the wing glove does not have a drastic effect on the aircraft flight characteristics. TRANAIR, a non-linear full potential solver was used to analyze a full aircraft, with and without a glove, at a variety of flight conditions and angles of attack and sideslip. Changes in the aircraft lift, drag and side force, along with roll, pitch and yawing moment are presented. Span lift and moment distributions are also presented for a more detailed look at the effects of the glove on the aircraft. Aerodynamic flow phenomena due to the addition of the glove and its fairing are discussed. Results show that the glove used here does not present a drastic change in forces and moments on the aircraft, but an added torsional moment around the quarter-chord of the wing may be a cause for some structural concerns.

Multi-objective decision-making model based on CBM for an aircraft fleet

Science.gov (United States)

Luo, Bin; Lin, Lin

2018-04-01

Modern production management patterns, in which multi-unit (e.g., a fleet of aircrafts) are managed in a holistic manner, have brought new challenges for multi-unit maintenance decision making. To schedule a good maintenance plan, not only does the individual machine maintenance have to be considered, but also the maintenance of the other individuals have to be taken into account. Since most condition-based maintenance researches for aircraft focused on solely reducing maintenance cost or maximizing the availability of single aircraft, as well as considering that seldom researches concentrated on both the two objectives: minimizing cost and maximizing the availability of a fleet (total number of available aircraft in fleet), a multi-objective decision-making model based on condition-based maintenance concentrated both on the above two objectives is established. Furthermore, in consideration of the decision maker may prefer providing the final optimal result in the form of discrete intervals instead of a set of points (non-dominated solutions) in real decision-making problem, a novel multi-objective optimization method based on support vector regression is proposed to solve the above multi-objective decision-making model. Finally, a case study regarding a fleet is conducted, with the results proving that the approach efficiently generates outcomes that meet the schedule requirements.

Proceedings of impact of aircraft emissions upon the atmosphere. V. 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-31

The study of the effect of aircraft on atmosphere is a new challenge that the scientific community has to face. This conference`s topics are various aspects of this challenge. The seven sessions of Volume 1 are: Present status and perspectives; Emission and traffic; Physics and chemistry of the aircraft wake; Natural and anthropogenic emissions - specific instrumentation; Global scale - chemistry; Global scale - climate. The 51 papers of Vol. 1. were indexed and abstracted individually for the Energy Database. (R.P.)

Proceedings of impact of aircraft emissions upon the atmosphere. V. 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

The study of the effect of aircraft on atmosphere is a new challenge that the scientific community has to face. This conference`s topics are various aspects of this challenge. The seven sessions of Volume 1 are: Present status and perspectives; Emission and traffic; Physics and chemistry of the aircraft wake; Natural and anthropogenic emissions - specific instrumentation; Global scale - chemistry; Global scale - climate. The 51 papers of Vol. 1. were indexed and abstracted individually for the Energy Database. (R.P.)

The G protein Gi1 exhibits basal coupling but not preassembly with G protein-coupled receptors.

Science.gov (United States)

Bondar, Alexey; Lazar, Josef

2017-06-09

The G i/o protein family transduces signals from a diverse group of G protein-coupled receptors (GPCRs). The observed specificity of G i/o -GPCR coupling and the high rate of G i/o signal transduction have been hypothesized to be enabled by the existence of stable associates between G i/o proteins and their cognate GPCRs in the inactive state (G i/o -GPCR preassembly). To test this hypothesis, we applied the recently developed technique of two-photon polarization microscopy (2PPM) to Gα i1 subunits labeled with fluorescent proteins and four GPCRs: the α 2A -adrenergic receptor, GABA B , cannabinoid receptor type 1 (CB 1 R), and dopamine receptor type 2. Our experiments with non-dissociating mutants of fluorescently labeled Gα i1 subunits (exhibiting impaired dissociation from activated GPCRs) showed that 2PPM is capable of detecting GPCR-G protein interactions. 2PPM experiments with non-mutated fluorescently labeled Gα i1 subunits and α 2A -adrenergic receptor, GABA B , or dopamine receptor type 2 receptors did not reveal any interaction between the G i1 protein and the non-stimulated GPCRs. In contrast, non-stimulated CB 1 R exhibited an interaction with the G i1 protein. Further experiments revealed that this interaction is caused solely by CB 1 R basal activity; no preassembly between CB 1 R and the G i1 protein could be observed. Our results demonstrate that four diverse GPCRs do not preassemble with non-active G i1 However, we also show that basal GPCR activity allows interactions between non-stimulated GPCRs and G i1 (basal coupling). These findings suggest that G i1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Design definition study of a lift/cruise fan technology V/STOL aircraft. Volume 1: Navy operational aircraft

Science.gov (United States)

1975-01-01

Aircraft were designed and sized to meet Navy mission requirements. Five missions were established for evaluation: anti-submarine warfare (ASW), surface attack (SA), combat search and rescue (CSAR), surveillance (SURV), and vertical on-board delivery (VOD). All missions were performed with a short takeoff and a vertical landing. The aircraft were defined using existing J97-GE gas generators or reasonable growth derivatives in conjunction with turbotip fans reflecting LF460 type technology. The multipurpose aircraft configuration established for U.S. Navy missions utilizes the turbotip driven lift/cruise fan concept for V/STOL aircraft.

Assessing effects of military aircraft noise on residential property values near airbases

Science.gov (United States)

Fidell, Sanford; Tabachnick, Barbara; Silvati, Laura; Cook, Brenda

The question, 'Does military aircraft noise exposure affect residential property values in the vicinity of Air Force bases?', can be asked and answered with varying degrees of generality and tolerable errors of inference. Definitive answers are difficult to develop because the question itself may not be meaningful in some circumstances: property values are affected by many factors other than aircraft noise which can fluctuate greatly in different areas and during different time periods; credible attribution of causality for changes in property values uniquely to aircraft noise requires many costly study design measures; and prior findings suggest that if a relationship exists, it is not a large or especially strong one. Thus, evidence of a simple geographic association between aircraft noise exposure and residential property values does not provide a conclusive answer to the question. In an effort to develop more compelling evidence, the US Air Force is planning to compare historical records of sale prices of properties in areas of differential aircraft noise exposure during specific time periods with predictions of sale prices derived from a validated statistical model of residential property values.

Aircraft emission inventories for scheduled air traffic for the 1976-92 time period. Historical trends

Energy Technology Data Exchange (ETDEWEB)

Baughcum, S L; Henderson, S C; Tritz, T G [Boeing Co., Seattle, WA (United States)

1998-12-31

Emission inventories of fuel burned, NO{sub x}, CO, and hydrocarbons have been calculated for scheduled air traffic in 1976, 1984, 1990 and 1992 on a 1 deg latitude x 1 deg longitude x 1 km pressure altitude grid. Using this database, the seasonal variation and historical trends in aircraft emissions have been calculated for selected geographical regions (e.g., North Atlantic, Europe, North America, North Pacific). The trend in emissions is a combination of the effects of passenger demand growth, improved aircraft efficiency, changes in combustor characteristics, and aircraft size. (author) 8 refs.

Aircraft emission inventories for scheduled air traffic for the 1976-92 time period. Historical trends

Energy Technology Data Exchange (ETDEWEB)

Baughcum, S.L.; Henderson, S.C.; Tritz, T.G. [Boeing Co., Seattle, WA (United States)

1997-12-31

Emission inventories of fuel burned, NO{sub x}, CO, and hydrocarbons have been calculated for scheduled air traffic in 1976, 1984, 1990 and 1992 on a 1 deg latitude x 1 deg longitude x 1 km pressure altitude grid. Using this database, the seasonal variation and historical trends in aircraft emissions have been calculated for selected geographical regions (e.g., North Atlantic, Europe, North America, North Pacific). The trend in emissions is a combination of the effects of passenger demand growth, improved aircraft efficiency, changes in combustor characteristics, and aircraft size. (author) 8 refs.

GRAPHICAL MODELS OF THE AIRCRAFT MAINTENANCE PROCESS

Directory of Open Access Journals (Sweden)

Stanislav Vladimirovich Daletskiy

2017-01-01

Full Text Available The aircraft maintenance is realized by a rapid sequence of maintenance organizational and technical states, its re- search and analysis are carried out by statistical methods. The maintenance process concludes aircraft technical states con- nected with the objective patterns of technical qualities changes of the aircraft as a maintenance object and organizational states which determine the subjective organization and planning process of aircraft using. The objective maintenance pro- cess is realized in Maintenance and Repair System which does not include maintenance organization and planning and is a set of related elements: aircraft, Maintenance and Repair measures, executors and documentation that sets rules of their interaction for maintaining of the aircraft reliability and readiness for flight. The aircraft organizational and technical states are considered, their characteristics and heuristic estimates of connection in knots and arcs of graphs and of aircraft organi- zational states during regular maintenance and at technical state failure are given. It is shown that in real conditions of air- craft maintenance, planned aircraft technical state control and maintenance control through it, is only defined by Mainte- nance and Repair conditions at a given Maintenance and Repair type and form structures, and correspondingly by setting principles of Maintenance and Repair work types to the execution, due to maintenance, by aircraft and all its units mainte- nance and reconstruction strategies. The realization of planned Maintenance and Repair process determines the one of the constant maintenance component. The proposed graphical models allow to reveal quantitative correlations between graph knots to improve maintenance processes by statistical research methods, what reduces manning, timetable and expenses for providing safe civil aviation aircraft maintenance.

Retrieving Storm Electric Fields from Aircraft Field Mill Data. Part 1; Theory

Science.gov (United States)

Koshak, W. J.

2006-01-01

It is shown that the problem of retrieving storm electric fields from an aircraft instrumented with several electric field mill sensors can be expressed in terms of a standard Lagrange multiplier optimization problem. The method naturally removes aircraft charge from the retrieval process without having to use a high voltage stinger and linearly combined mill data values. It allows a variety of user-supplied physical constraints (the so-called side constraints in the theory of Lagrange multipliers) and also helps improve absolute calibration. Additionally, this paper introduces an alternate way of performing the absolute calibration of an aircraft that has some benefits over conventional analyses. It is accomplished by using the time derivatives of mill and pitch data for a pitch down maneuver performed at high (greater than 1 km) altitude. In Part II of this study, the above methods are tested and then applied to complete a full calibration of a Citation aircraft.

Database on aircraft accidents

International Nuclear Information System (INIS)

Nishio, Masahide; Koriyama, Tamio

2013-11-01

The Reactor Safety Subcommittee in the Nuclear Safety and Preservation Committee published 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' as the standard method for evaluating probability of aircraft crash into nuclear reactor facilities in July 2002. In response to this issue, Japan Nuclear Energy Safety Organization has been collecting open information on aircraft accidents of commercial airplanes, self-defense force (SDF) airplanes and US force airplanes every year since 2003, sorting out them and developing the database of aircraft accidents for the latest 20 years to evaluate probability of aircraft crash into nuclear reactor facilities. In this report the database was revised by adding aircraft accidents in 2011 to the existing database and deleting aircraft accidents in 1991 from it, resulting in development of the revised 2012 database for the latest 20 years from 1992 to 2011. Furthermore, the flight information on commercial aircrafts was also collected to develop the flight database for the latest 20 years from 1992 to 2011 to evaluate probability of aircraft crash into reactor facilities. The method for developing the database of aircraft accidents to evaluate probability of aircraft crash into reactor facilities is based on the report 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' described above. The 2012 revised database for the latest 20 years from 1992 to 2011 shows the followings. The trend of the 2012 database changes little as compared to the last year's report. (1) The data of commercial aircraft accidents is based on 'Aircraft accident investigation reports of Japan transport safety board' of Ministry of Land, Infrastructure, Transport and Tourism. The number of commercial aircraft accidents is 4 for large fixed-wing aircraft, 58 for small fixed-wing aircraft, 5 for large bladed aircraft and 99 for small bladed aircraft. The relevant accidents

Assessment of aircraft risk reduction at Pantex Plant

International Nuclear Information System (INIS)

Lin, Y.T.; Hedtke, R.; Fike, D.; Diniz, J.

1996-01-01

The possibility of an aircraft crashing into the Department of Energy's (DOE) Pantex plant facility has been of concern in risk assessments. In response to public concerns, and in an effort to reduce risks associated with overflights of Pantex, several changes to navigational aids at Amarillo International Airport have been implemented. For over one year, a radar airspace monitor and recording system has been connected to the airport surveillance radar at Amarillo to record the flight paths, aircraft types, and traffic density of aircraft in the vicinity of the Pantex plant. The data has provided a better understanding of the overflight risk at Pantex as well as a means to measure the effectiveness of risk reduction efforts

Disruption Management for an Airline - Rescheduling of aircraft

DEFF Research Database (Denmark)

Larsen, Jesper; Løve, Michael; Sørensen, Kim Riis

2002-01-01

The Aircraft Recovery Problem (ARP) involves decisions concerning aircraft to flight assignments in situations where unforseen events have disrupted the existing flight schedule, e.g. bad weather causing flight delays. The aircraft recovery problem aims to recover these flight schedules through...... a series of reassignments of aircraft to flights, delaying of flights and cancellations of flights. This article demonstrates an effective method to solve ARP. A heuristic is implemented, which is able to generate feasible revised flight schedules of a good quality in less than 10 seconds. This article...

Analysing the effects of rigid and flexible aircraft dynamics on the ejection of a large store

CSIR Research Space (South Africa)

Jamison, Kevin

2011-09-01

Full Text Available duration ? ERU forces + store weight release causes aircraft ?g-jump? ? Period of ERU force is short enough to excite wing vibration modes ? ERU force/time & front/back force balance important for determining store separation rates from aircraft... ? Constrained motion in other DOF ? Used mass, inertias, CG of aircraft without Katleho ? Used trimmed forces of aircraft with Katleho ? Assumes delay in pilot response to g-jump ? CSIR 2011 Slide 14 Aircraft rigid accelerations Aircraft mass...

Safety assurance of non-deterministic flight controllers in aircraft applications

Science.gov (United States)

Noriega, Alfonso

Loss of control is a serious problem in aviation that primarily affects General Aviation. Technological advancements can help mitigate the problem, but the FAA certification process makes certain solutions economically unfeasible. This investigation presents the design of a generic adaptive autopilot that could potentially lead to a single certification for use in several makes and models of aircraft. The autopilot consists of a conventional controller connected in series with a robust direct adaptive model reference controller. In this architecture, the conventional controller is tuned once to provide outer-loop guidance and navigation to a reference model. The adaptive controller makes unknown aircraft behave like the reference model, allowing the conventional controller to successfully provide navigation without the need for retuning. A strong theoretical foundation is presented as an argument for the safety and stability of the controller. The stability proof of direct adaptive controllers require that the plant being controlled has no unstable transmission zeros and has a nonzero high frequency gain. Because most conventional aircraft do not readily meet these requirements, a process known as sensor blending was used. Sensor blending consists of using a linear combination of the plant's outputs that has no unstable transmission zeros and has a nonzero high frequency gain to drive the adaptive controller. Although this method does not present a problem for regulators, it can lead to a steady state error in tracking applications. The sensor blending theory was expanded to take advantage of the system's dynamics to allow for zero steady state error tracking. This method does not need knowledge of the specific system's dynamics, but instead uses the structure of the A and B matrices to perform the blending for the general case. The generic adaptive autopilot was tested in two high-fidelity nonlinear simulators of two typical General Aviation aircraft. The results

Does the G-spot exist? A review of the current literature.

Science.gov (United States)

Puppo, Vincenzo; Gruenwald, Ilan

2012-12-01

In 1950, Gräfenberg described a distinct erotogenic zone on the anterior wall of the vagina, which was referred to as the Gräfenberg spot (G-spot) by Addiego, Whipple (a nurse) et al. in 1981. As a result, the G-spot has become a central topic of popular speculation and a basis of a huge business surrounding it. In our opinion, these sexologists have made a hotchpotch of Gräfenberg's thoughts and ideas that were set forth and expounded in his 1950 article: the intraurethral glands are not the corpus spongiosum of the female urethra, and Gräfenberg did not report an orgasm of the intraurethral glands. G-spot amplification is a cosmetic surgery procedure for temporarily increasing the size and sensitivity of the G-spot in which a dermal filler or a collagen-like material is injected into the bladder-vaginal septum. All published scientific data point to the fact that the G-spot does not exist, and the supposed G-spot should not be identified with Gräfenberg's name. Moreover, G-spot amplification is not medically indicated and is an unnecessary and inefficacious medical procedure.

48 CFR 1352.228-74 - Fair market value of aircraft.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fair market value of... Fair market value of aircraft. As prescribed in 48 CFR 1328.310-70(e) and 48 CFR 1328.310-70(g) insert the following in all applicable contracts for leased aircraft: Fair Market Value of Aircraft (APR 2010...

Measurement of dose equivalent distribution on-board commercial jet aircraft

International Nuclear Information System (INIS)

Kubancak, J.; Ambrozova, I.; Ploc, O.; Pachnerova Brabcova, K.; Stepan, V.; Uchihori, Y.

2014-01-01

The annual effective doses of aircrew members often exceed the limit of 1 mSv for the public due to the increased level of cosmic radiation at the flight altitudes, and thus, it is recommended to monitor them [International Commission on Radiation Protection. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann. ICRP 21(1-3), (1991)]. According to the Monte Carlo simulations [Battistoni, G., Ferrari, A., Pelliccioni, M. and Villari, R. Evaluation of the doses to aircrew members taking into consideration the aircraft structures. Adv. Space Res. 36, 1645-1652 (2005) and Ferrari, A., Pelliccioni, M. and Villari, R. Evaluation of the influence of aircraft shielding on the aircrew exposure through an aircraft mathematical model. Radiat. Prot. Dosim. 108(2), 91-105 (2004)], the ambient dose equivalent rate H*(10) depends on the location in the aircraft. The aim of this article is to experimentally evaluate H*(10) on-board selected types of aircraft. The authors found that H*(10) values are higher in the front and the back of the cabin and lesser in the middle of the cabin. Moreover, total dosimetry characteristics obtained in this way are in a reasonable agreement with other data, in particular with the above-mentioned simulations. (authors)

The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5.

Science.gov (United States)

Zhu, Jinliang; Li, Ming; Chen, Lixue; Liu, Ping; Qiao, Jie

2014-07-01

Does protein source or human serum albumin (HSA) in embryo culture media influence the subsequent birthweight? A significant difference was observed in gestational age- and gender-adjusted birthweight (Z scores) and the proportion of large-for-gestational age (LGA) babies between embryos cultured in G1 v5 and those cultured in G1-PLUS v5 media. It has been reported that the birthweights of singletons born from embryos cultured in Vitrolife are significantly higher than those cultured in the Cook group of media, and that G1-PLUS (Vitrolife, Gothenburg, Sweden) is associated with increased birth and placenta weights compared with Medicult ISMI. This study was a retrospective analysis of neonatal birthweights, and included 1097 singletons born from fresh embryo transfer cycles at the Center for Reproductive Medicine of Peking University Third Hospital between January 2011 and August 2012. The number of singletons born from G1 v5 culture media was 489, and the number of singletons born from G1-PLUS v5 media was 608. Patients media groups. The absolute birthweights for singletons resulting from G1-PLUS v5 were not different from singletons resulting from G1 v5 (3375.9 ± 479.6 g versus 3333.2 ± 491.6 g, respectively; P = 0.14). However the Z scores for singletons from embryos cultured in G1-PLUS v5 were significantly higher than for singletons cultured in G1 v5 (0.28 ± 1.12 versus 0.09 ± 1.15, respectively; P = 0.04), and more LGA babies were born from G1-PLUS v5 culture compared with G1 v5 (16.8 versus 12.1%, respectively; P = 0.03) culture. Finally, multiple linear regression analysis suggested that female weight (P = 0.00), male height (P = 0.04), gestational age at birth (P = 0.00), infant gender (P = 0.00) and culture media (P = 0.04) all had significant effects on the birthweights of singleton newborns. This study was limited by its retrospective design. Our study suggests that protein source/HSA has a significant effect on birthweights of singleton newborns

Measurement Capabilities of the DOE ARM Aerial Facility

Science.gov (United States)

Schmid, B.; Tomlinson, J. M.; Hubbe, J.; Comstock, J. M.; Kluzek, C. D.; Chand, D.; Pekour, M. S.

2012-12-01

The Department of Energy Atmospheric Radiation Measurement (ARM) Program is a climate research user facility operating stationary ground sites in three important climatic regimes that provide long-term measurements of climate relevant properties. ARM also operates mobile ground- and ship-based facilities to conduct shorter field campaigns (6-12 months) to investigate understudied climate regimes around the globe. Finally, airborne observations by ARM's Aerial Facility (AAF) enhance the surface-based ARM measurements by providing high-resolution in situ measurements for process understanding, retrieval algorithm development, and model evaluation that is not possible using ground-based techniques. AAF started out in 2007 as a "virtual hangar" with no dedicated aircraft and only a small number of instruments owned by ARM. In this mode, AAF successfully carried out several missions contracting with organizations and investigators who provided their research aircraft and instrumentation. In 2009, the Battelle owned G-1 aircraft was included in the ARM facility. The G-1 is a large twin turboprop aircraft, capable of measurements up to altitudes of 7.5 km and a range of 2,800 kilometers. Furthermore the American Recovery and Reinvestment Act of 2009 provided funding for the procurement of seventeen new instruments to be used aboard the G-1 and other AAF virtual-hangar aircraft. AAF now executes missions in the virtual- and real-hangar mode producing freely available datasets for studying aerosol, cloud, and radiative processes in the atmosphere. AAF is also heavily engaged in the maturation and testing of newly developed airborne sensors to help foster the next generation of airborne instruments. In the presentation we will showcase science applications based on measurements from recent field campaigns such as CARES, CALWATER and TCAP.

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

NARCIS (Netherlands)

Bogdanovich, Sasha; Kim, Younghee; Mizutani, Takeshi; Yasuma, Reo; Tudisco, Laura; Cicatiello, Valeria; Bastos-Carvalho, Ana; Kerur, Nagaraj; Hirano, Yoshio; Baffi, Judit Z; Tarallo, Valeria; Li, Shengjian; Yasuma, Tetsuhiro; Arpitha, Parthasarathy; Fowler, Benjamin J; Wright, Charles B; Apicella, Ivana; Greco, Adelaide; Brunetti, Arturo; Ruvo, Menotti; Sandomenico, Annamaria; Nozaki, Miho; Ijima, Ryo; Kaneko, Hiroki; Ogura, Yuichiro; Terasaki, Hiroko; Ambati, Balamurali K; Leusen, Jeanette HW; Langdon, Wallace Y; Clark, Michael R; Armour, Kathryn L; Bruhns, Pierre; Verbeek, J Sjef; Gelfand, Bradley D; De Falco, Sandro; Ambati, Jayakrishna

2016-01-01

Aberrant angiogenesis is implicated in diseases affecting nearly 10% of the world's population. The most widely used anti-angiogenic drug is bevacizumab, a humanized IgG1 monoclonal antibody that targets human VEGFA. Although bevacizumab does not recognize mouse Vegfa, it inhibits angiogenesis in

Assimilation of Aircraft Observations in High-Resolution Mesoscale Modeling

Directory of Open Access Journals (Sweden)

Brian P. Reen

2018-01-01

Full Text Available Aircraft-based observations are a promising source of above-surface observations for assimilation into mesoscale model simulations. The Tropospheric Airborne Meteorological Data Reporting (TAMDAR observations have potential advantages over some other aircraft observations including the presence of water vapor observations. The impact of assimilating TAMDAR observations via observation nudging in 1 km horizontal grid spacing Weather Research and Forecasting model simulations is evaluated using five cases centered over California. Overall, the impact of assimilating the observations is mixed, with the layer with the greatest benefit being above the surface in the lowest 1000 m above ground level and the variable showing the most consistent benefit being temperature. Varying the nudging configuration demonstrates the sensitivity of the results to details of the assimilation, but does not clearly demonstrate the superiority of a specific configuration.

Database on aircraft accidents

International Nuclear Information System (INIS)

Nishio, Masahide; Koriyama, Tamio

2012-09-01

The Reactor Safety Subcommittee in the Nuclear Safety and Preservation Committee published the report 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' as the standard method for evaluating probability of aircraft crash into nuclear reactor facilities in July 2002. In response to the report, Japan Nuclear Energy Safety Organization has been collecting open information on aircraft accidents of commercial airplanes, self-defense force (SDF) airplanes and US force airplanes every year since 2003, sorting out them and developing the database of aircraft accidents for latest 20 years to evaluate probability of aircraft crash into nuclear reactor facilities. This year, the database was revised by adding aircraft accidents in 2010 to the existing database and deleting aircraft accidents in 1991 from it, resulting in development of the revised 2011 database for latest 20 years from 1991 to 2010. Furthermore, the flight information on commercial aircrafts was also collected to develop the flight database for latest 20 years from 1991 to 2010 to evaluate probability of aircraft crash into reactor facilities. The method for developing the database of aircraft accidents to evaluate probability of aircraft crash into reactor facilities is based on the report 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' described above. The 2011 revised database for latest 20 years from 1991 to 2010 shows the followings. The trend of the 2011 database changes little as compared to the last year's one. (1) The data of commercial aircraft accidents is based on 'Aircraft accident investigation reports of Japan transport safety board' of Ministry of Land, Infrastructure, Transport and Tourism. 4 large fixed-wing aircraft accidents, 58 small fixed-wing aircraft accidents, 5 large bladed aircraft accidents and 114 small bladed aircraft accidents occurred. The relevant accidents for evaluating

Avaliação das subclasses IgG1 e IgG3 na doença hemolítica perinatal Assessment of IgG1 and IgG3 subclasses in perinatal hemolytic disease

Directory of Open Access Journals (Sweden)

Maria A. Araújo

2003-01-01

associated with the mild hemolytic form of the disease, whereas the association of IgG1 and IgG3 suggested a clinically more severe form of HDN. It is possible, however, that the severity in these cases is related to the presence of IgG1. These results suggest that IgG1 and IgG3 isotypes should be included in multi-parametric protocols for the evaluation of clinical severity of HDN, as International literature does not give support to the use of IgG subclass determination alone as a reliable indicator to predict severity or prognosis of the disease.

Plotting the Flight Envelope of an Unmanned Aircraft System Air Vehicle

Directory of Open Access Journals (Sweden)

Glīzde Nikolajs

2017-08-01

Full Text Available The research is focused on the development of an Unmanned Aircraft System. One of the design process steps in the preliminary design phase is the calculation of the flight envelope for the Unmanned Aircraft System air vehicle. The results obtained will be used in the further design process. A flight envelope determines the minimum requirements for the object in Certification Specifications. The present situation does not impose any Certification Specification requirements for the class of the Unmanned Aircraft System under the development of the general European Union trend defined in the road map for the implementation of the Unmanned Aircraft System. However, operation in common European Aerospace imposes the necessity for regulations for micro class systems as well.

A plume-in-grid approach to characterize air quality impacts of aircraft emissions at the Hartsfield–Jackson Atlanta International Airport

Directory of Open Access Journals (Sweden)

J. Rissman

2013-09-01

contribution to the grid cells. Maximum puff impacts are seen within the 12 km × 12 km ring, not in the airport's own grid cell, while maximum grid cell impacts occur within the airport's grid cell. Twenty-one (21% of all aircraft-related puffs from the Atlanta airport have at least 0.1 μg m−3 PM2.5 concentrations. Near the airport, median daily puff concentrations vary between 0.017 and 0.134 μg m−3 (0.05 and 0.35 μg m−3 at ground level, while maximum daily puff concentrations vary between 6.1 and 42.1 μg m−3 (7.5 and 42.1 μg m−3 at ground level during the 2-month period. In contrast, median daily aircraft contribution to grid concentrations varies between 0.015 and 0.091 μg m−3 (0.09 and 0.40 μg m−3 at ground level, while the maximum varies between 0.75 and 2.55 μg m−3 (0.75 and 2.0 μg m−3 at ground level. Future researchers may consider using a plume-in-grid process, such as the one used here, to understand the impacts of aircraft emissions at other airports, for proposed future airports, for airport expansion projects under various future scenarios, and for other national-scale studies specifically when the maximum impacts at fine scales are of interest.

19 CFR 122.134 - When airline does not have in-bond liquor storeroom.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false When airline does not have in-bond liquor storeroom. 122.134 Section 122.134 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.134 When airline does not have in-bond liquor storeroom. (a...

Evolution of Flying Qualities Analysis: Problems for a New Generation of Aircraft

Science.gov (United States)

2010-03-29

speed. . . Inability to balance and steer still confronts students of the flying problem . . .When this one feature has been worked out, the age of...30 −20 −10 0 10 20 M ag ni tu de ( dB ) 10 −1 10 0 10 1 10 2 −180 −135 −90 −45 0 P ha se ( de g) Bode Diagram, ω n =4, ζ = 0.65 Frequency (rad/sec... Unicorn Silverfox Vertex SPAARO C 152 R ey no ld s N um be r Gross Takeoff Weight (lbs) Comparison of Aircraft Figure 5.4: Aircraft operational

Analysis of ({sup 7}F{sub 0}){gamma}{sub 1g}{yields}({sup 5}D{sub 2}){gamma}{sub 5g}, {gamma}{sub 3g} and ({sup 7}F{sub 0}){gamma}{sub 1g}{yields}({sup 5}L{sub 6}){gamma}{sub 1g}, a{gamma}{sub 5g} two-photon absorption spectra of Cs{sub 2}NaYF{sub 6}:Eu{sup 3+}

Energy Technology Data Exchange (ETDEWEB)

Ning Lixin; Wang Dianyuan; Xia Shangda [Structure Research Laboratory, Academica Sinica, Department of Physics, University of Science and Technology of China, Heifei, Anhui (China); Thorne, Jonathan R.G. [Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford (United Kingdom); Tanner, Peter A. [Department of Biology and Chemistry, City University of Hong Kong, Kowloon (China)

2002-04-15

The direct calculation of transition line strengths and relative intensities is presented for two intraconfigurational two-photon absorption (TPA) transitions of Eu{sup 3+} in the cubic Cs{sub 2}NaYF{sub 6} host. Crystal field wavefunctions were utilized for the initial and final f{sup N}-electron states and various approaches were used in constructing all the 4f{sup N-1} 5d{sup 1} intermediate-state wavefunctions. The calculated relative intensities of the ({sup 7}F{sub 0}) {gamma}{sub 1g}{yields}({sup 5}D{sub 2}){gamma}{sub 5g}, {gamma}{sub 3g} TPA transitions are in reasonable agreement with experiment. The neglect of J-mixing in the initial state has only a small effect upon the calculation, whereas the neglect of spin-orbit couplings within the initial and terminal states drastically reduces the calculated transition linestrengths, but does not markedly change the intensity ratios. In the case of the ({sup 7}F{sub 0}){gamma}{sub 1g}{yields}({sup 5}L{sub 6}){gamma}{sub 1g}, a{gamma}{sub 5g} transitions, serious discrepancies between experiment and theory are found if the intermediate states are constructed from a 4f{sup 5} core comprising free ion states and the 5d{sup 1} crystal field states. Satisfactory agreement is, however, found when the 4f{sup 5} crystal field states are utilized in constructing the intermediate states. The contributions to the transition moment have been evaluated for various Hamiltonian terms and the results are discussed. (author)

Sulfuric Acid and Soot Particles in Aircraft Exhaust

Science.gov (United States)

Pueschel, Rudolf F.; Verma, S.; Ferry, G. V.; Goodman, J.; Strawa, A. W.; Gore, Warren J. Y. (Technical Monitor)

1997-01-01

Aircraft have become the fastest, fairly convenient and, in most cases of long-distance travel, most economical mode of travel. This is reflected in the increase of commercial air traffic at a rate of 6% per year since 1978. Future annual growth rates of passenger miles of 4% for domestic and 6% for international routes are projected. A still larger annual increase of 8.5% is expected for the Asia/Pacific region. To meet that growth, Boeing predicts the addition of 15,900 new aircraft to the world's fleets, valued at more than $1.1 trillion, within the next 20 years. The largest concern of environmental consequences of aircraft emissions deals with ozone (O3), because: (1) the O3 layer protects the blaspheme from short-ultraviolet radiation that can cause damage to human, animal and plant life, and possibly affect agricultural production and the marine food chain; (2) O3 is important for the production of the hydroxyl radical (OH) which, in turn, is responsible for the destruction of other greenhouse gases, e.g., methane (CH4) and for the removal of other pollutants, and (3) O3 is a greenhouse gas. Additional information is contained in the original extended abstract.

FAA-NASA Sixth International Conference on the Continued Airworthiness of Aircraft Structures

Science.gov (United States)

1995-12-01

Administration, and Colin G. Drury , State University of New York at Buffalo The Aging Aircraft Nondestructive Inspection Validation Center - A R esource for...William T. Shepherd FAA-Office of Aviation Medicine Washington, DC and Colin G. Drury State University of New York at Buffalo Buffalo, NY INTRODUCTION FAA’s...improvement, changing the task, the operator (inspector), machine, or environment as appropriate, e.g., review in Drury , 1992 (Ref. 1). 2. From the

Oxygen demand of aircraft and airfield pavement deicers and alternative freezing point depressants

Science.gov (United States)

Corsi, Steven R.; Mericas, Dean; Bowman, George

2012-01-01

Aircraft and pavement deicing formulations and other potential freezing point depressants were tested for biochemical oxygen demand (BOD) and chemical oxygen demand (COD). Propylene glycol-based aircraft deicers exhibited greater BOD5 than ethylene glycol-based aircraft deicers, and ethylene glycol-based products had lower degradation rates than propylene glycol-based products. Sodium formate pavement deicers had lower COD than acetate-based pavement deicers. The BOD and COD results for acetate-based pavement deicers (PDMs) were consistently lower than those for aircraft deicers, but degradation rates were greater in the acetate-based PDM than in aircraft deicers. In a 40-day testing of aircraft and pavement deicers, BOD results at 20°C (standard) were consistently greater than the results from 5°C (low) tests. The degree of difference between standard and low temperature BOD results varied among tested products. Freshwater BOD test results were not substantially different from marine water tests at 20°C, but glycols degraded slower in marine water than in fresh water for low temperature tests. Acetate-based products had greater percentage degradation than glycols at both temperatures. An additive component of the sodium formate pavement deicer exhibited toxicity to the microorganisms, so BOD testing did not work properly for this formulation. BOD testing of alternative freezing point depressants worked well for some, there was little response for some, and for others there was a lag in response while microorganisms acclimated to the freezing point depressant as a food source. Where the traditional BOD5 test performed adequately, values ranged from 251 to 1,580 g/kg. Where the modified test performed adequately, values of BOD28 ranged from 242 to 1,540 g/kg.

X-ray induction of 6-thioguanine-resistant mutants in division arrested, G0/G1 phase Chinese hamster ovary cells

Energy Technology Data Exchange (ETDEWEB)

O' Neill, J.P.; Flint, K.B.

The cytotoxic and mutagenic effect of X-irradiation was determined with Chinese hamster ovary cells arrested in the G0/G1 phase of the cell cycle through 9 days incubation in serum-free medium. In comparison with exponential phase cultures, the arrested cells showed increased cytotoxicity and mutation induction over the dose range of 50-800 rad. Exponential cultures showed a linear mutant frequency-survival relationship while the arrested cells showed a biphasic linear relationship. A post irradiation holding period 24 h does not result in any change in the mutant frequency. The increased sensitivity of the arrested cells to the mutagenic effects of X-rays appears to be a cell-cycle phase phenomenon. Upon readdition of serum, the arrested cells re-enter the cell cycle in a synchronous manner, reaching S phase at 10-12 h. Cells irradiated at 5 h after serum addition, i.e. in G1, show a similar dose response for mutant frequency, while those irradiated at 10 h or later, i.e. in late G1, S or G2, show lower mutation induction. These observations are consistent with a chromosome interchange mechanism of mutation induction by X-rays, possibly through interactions between repairing regions of the DNA. Irradiation of cells in the G0/G1 phase allow more time for such interactions in the absence of semiconservative DNA replication. (orig.).

Risk assessment of aircraft accidents anywhere near an airport

International Nuclear Information System (INIS)

Barbaran, Gustavo; Jensen Mariani Santiago Nicolas

2011-01-01

This work analyzes the more suitable areas to build new facilities, taking into account the conditions imposed by an airport located nearby. Initially, it describes the major characteristics of the airport. Then, the restrictions imposed to ensure the normal operation of the aircraft are analyzed. Following, there is a summary of the evolution of studies of aircraft accidents at nuclear facilities. In the second part, three models of aircraft crash probabilities are presented, all of them developed in the U.S.A, each with an increasing level of complexity in modeling the likelihood of accidents. The first model is the 'STD-3014' Department of Energy (DOE), the second is the 'ACRAM'(Aircraft Crash Risk Assessment Methodology) prepared by the 'Lawrence Livermore National Laboratory'(LLNL) and finally the more advanced 'ACRP-3', produced by the 'Transportation Research Board'. The results obtained with the three models establish that the risks imposed on the airport vicinity, remain low due to the improvement and innovation in the aircraft's safety, reducing the risk margin for the location of new nuclear facilities near an airport. (author) [es

EG and G Idaho environmental protection implementation plan

International Nuclear Information System (INIS)

Stump, R.C.

1989-11-01

This report describes the EG ampersand G Idaho strategy for implementation of the Department of Energy (DOE) Order 5400.1 (a DOE-Headquarters directive establishing environmental protection program requirements, authorities, and responsibilities). Preparation of this Environmental Protection Implementation Plan is a requirement of DOE Order 5400.0 Additionally, this report is intended to supplement the Department of Energy -- Idaho Operations Office (DOE-ID) Environmental Protection Implementation Plan by detailing EG ampersand G Idaho Environmental Protection Program activities. This report describes the current status of the EG ampersand G Idaho Program, and the strategies for enhancing, as necessary, the current program to meet the requirements of DOE Order 5400.1. Aspects of the Environmental Protection Program included in this report are the assignment of responsibilities to specific EG ampersand G organizations, a schedule for completion of enhancements, if necessary, and requirements for documentation and reporting. 3 figs., 1 tab

Does "g" Exist?

Science.gov (United States)

Detterman, Douglas K.

1982-01-01

In an argument for orthogonal variables to explain intelligence, higher-order constructs, including "g" as a single thing in intelligence, are suggested to inevitably result from complex systems with interrelated parts. Biological reductionism and other arguments for the higher-order constructs as explanations of intellectual functioning…

Hydroxyurea does not prevent synchronized G1 Chinese hamster cells from entering the DNA synthetic period

International Nuclear Information System (INIS)

Walters, R.A.; Tobey, R.A.; Hildebrand, C.E.

1976-01-01

Using very high concentrations of radioactively labeled thymidine, we show that synchronized G 1 cells treated with hydroxyurea entered the DNA synthetic period at a time and rate indistinguishable from that of untreated cells, although the rate of DNA synthesis was greatly reduced in the drug-treated cultures. The DNA synthesized in the presence of hydroxyurea was less than or equal to 1 x 10 7 daltons, all of which could be chased into bulk DNA of approximately 3.5 x 10 8 daltons within 3 hr after removal of hydroxyurea. Hydroxyurea synchronized cells are apparently not blocked at the G 1 /S boundary but in the S phase itself

Potential for Landing Gear Noise Reduction on Advanced Aircraft Configurations

Science.gov (United States)

Thomas, Russell H.; Nickol, Craig L.; Burley, Casey L.; Guo, Yueping

2016-01-01

The potential of significantly reducing aircraft landing gear noise is explored for aircraft configurations with engines installed above the wings or the fuselage. An innovative concept is studied that does not alter the main gear assembly itself but does shorten the main strut and integrates the gear in pods whose interior surfaces are treated with acoustic liner. The concept is meant to achieve maximum noise reduction so that main landing gears can be eliminated as a major source of airframe noise. By applying this concept to an aircraft configuration with 2025 entry-into-service technology levels, it is shown that compared to noise levels of current technology, the main gear noise can be reduced by 10 EPNL dB, bringing the main gear noise close to a floor established by other components such as the nose gear. The assessment of the noise reduction potential accounts for design features for the advanced aircraft configuration and includes the effects of local flow velocity in and around the pods, gear noise reflection from the airframe, and reflection and attenuation from acoustic liner treatment on pod surfaces and doors. A technical roadmap for maturing this concept is discussed, and the possible drag increase at cruise due to the addition of the pods is identified as a challenge, which needs to be quantified and minimized possibly with the combination of detailed design and application of drag reduction technologies.

SOFIA MID-INFRARED IMAGING AND CSO SUBMILLIMETER POLARIMETRY OBSERVATIONS OF G034.43+00.24 MM1

International Nuclear Information System (INIS)

Jones, T. J.; Gordon, Michael; Shenoy, Dinesh; Gehrz, R. D.; Vaillancourt, John E.; Krejny, M.

2016-01-01

We present 11.1 to 37.1 μ m imaging observations of the very dense molecular cloud core MM1 in G034.43+00.24 using FORCAST on SOFIA and submillimeter (submm) polarimetry using SHARP on the Caltech Submillimeter Observatory. We find that at the spatial resolution of SOFIA, the point-spread function (PSF) of MM1 is consistent with being a single source, as expected based on millimeter (mm) and submm observations. The spectral energy distributions (SEDs) of MM1 and MM2 have a warm component at the shorter wavelengths not seen in mm and submm SEDs. Examination of H(1.65 μ m) stellar polarimetry from the Galactic Plane Infrared Polarization Survey shows that G034 is embedded in an external magnetic field aligned with the Galactic Plane. The SHARP polarimetry at 450 μ m shows a magnetic field geometry in the vicinity of MM1 that does not line up with either the Galactic Plane or the mean field direction inferred from the CARMA interferometric polarization map of the central cloud core, but is perpendicular to the long filament in which G034 is embedded. The CARMA polarimetry does show evidence for grain alignment in the central region of the cloud core, and thus does trace the magnetic field geometry near the embedded Class 0 YSO.

Protection by Face Masks against H1N1 Virus on Trans-Pacific Passenger Aircraft, 2009

Centers for Disease Control (CDC) Podcasts

2013-07-10

Dr. Mike Miller reads an abridged version of the Emerging Infectious Diseases’ article, Protection by Face Masks against H1N1 Virus on Trans-Pacific Passenger Aircraft, 2009.  Created: 7/10/2013 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 7/11/2013.

Identification of Aircraft Hazards

International Nuclear Information System (INIS)

K. Ashley

2006-01-01

Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2005 [DIRS 174235], Section 6.4.1). That determination was conservatively based upon limited knowledge of flight data in the area of concern and upon crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a monitored geologic repository (MGR) at Yucca Mountain, using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987 [DIRS 103124], Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. The intended use of this report is to provide inputs for further screening and analysis of identified aircraft hazards based upon the criteria that apply to Category 1 and Category 2 event sequence analyses as defined in 10 CFR 63.2 [DIRS 176544] (Section 4). The scope of this report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the repository at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (Section 7)

The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size.

Directory of Open Access Journals (Sweden)

Karen Artiles

2009-11-01

Full Text Available The key molecular event that marks entry into the cell cycle is transcription of G1 cyclins, which bind and activate cyclin-dependent kinases. In yeast cells, initiation of G1 cyclin transcription is linked to achievement of a critical cell size, which contributes to cell-size homeostasis. The critical cell size is modulated by nutrients, such that cells growing in poor nutrients are smaller than cells growing in rich nutrients. Nutrient modulation of cell size does not work through known critical regulators of G1 cyclin transcription and is therefore thought to work through a distinct pathway. Here, we report that Rts1, a highly conserved regulatory subunit of protein phosphatase 2A (PP2A, is required for normal control of G1 cyclin transcription. Loss of Rts1 caused delayed initiation of bud growth and delayed and reduced accumulation of G1 cyclins. Expression of the G1 cyclin CLN2 from an inducible promoter rescued the delayed bud growth in rts1Delta cells, indicating that Rts1 acts at the level of transcription. Moreover, loss of Rts1 caused altered regulation of Swi6, a key component of the SBF transcription factor that controls G1 cyclin transcription. Epistasis analysis revealed that Rts1 does not work solely through several known critical upstream regulators of G1 cyclin transcription. Cells lacking Rts1 failed to undergo nutrient modulation of cell size. Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates.

EG and G Idaho Environmental Protection Implementation Plan (1990)

Energy Technology Data Exchange (ETDEWEB)

Wickham, L.E.

1990-11-01

This report describes the EG G Idaho strategy for implementation of the Department of Energy (DOE) Order 5400.1 (a DOE-Headquarters directive establishing environmental protection program requirements, authorities, and responsibilities). Preparation of this Environmental Protection Implementation Plan is a requirement of DOE Order 5400.1. Additionally, this report is intended to supplement the Department of Energy--Idaho Operations Office (DOE-ID) Environmental Protection Implementation Plan by detailing EG G Idaho Environmental Protection Program activities. This report describes the current status of the EG G Idaho program, and the strategies for enhancing, as necessary, the current program to meet the requirements of DOE Order 5400.1. Aspects of the Environmental Protection Program included in this report are the assignment of responsibilities to specific EG G organizations, a schedule for completion of enhancements, if necessary, and requirements for documentation and reporting. 4 figs., 1 tab.

EG and G Idaho Environmental Protection Implementation Plan (1991)

Energy Technology Data Exchange (ETDEWEB)

Graham, J.F.

1991-11-01

This report describes the EG G Idaho, Inc. strategy for implementation of the Department of Energy (DOE) Order 5400.1 (a DOE-Headquarters directive establishing environmental protection program requirements, authorities, and responsibilities). Preparation of this Environmental Protection Implementation Plan is a requirement of DOE Order 5400.1. Additionally, this report is intended to supplement the Department of Energy -- Field Office Idaho (DOE-ID) Environmental Protection Implementation Plan by detailing EG G Idaho Environmental Protection Program activities. This report describes the current status of the EG G Idaho Program, and the strategies for enhancing, as necessary, the current program to meet the requirements of DOE Order 5400.1. Aspects of the Environmental Protection Program included in this report are the assignment of responsibilities to specific EG G Idaho organizations, a schedule for completion of enhancements, if necessary, and requirements for documentation and reporting. 4 figs., 1 tab.

EG and G Idaho Environmental Protection Implementation Plan (1991)

International Nuclear Information System (INIS)

Graham, J.F.

1991-11-01

This report describes the EG ampersand G Idaho, Inc. strategy for implementation of the Department of Energy (DOE) Order 5400.1 (a DOE-Headquarters directive establishing environmental protection program requirements, authorities, and responsibilities). Preparation of this Environmental Protection Implementation Plan is a requirement of DOE Order 5400.1. Additionally, this report is intended to supplement the Department of Energy -- Field Office Idaho (DOE-ID) Environmental Protection Implementation Plan by detailing EG ampersand G Idaho Environmental Protection Program activities. This report describes the current status of the EG ampersand G Idaho Program, and the strategies for enhancing, as necessary, the current program to meet the requirements of DOE Order 5400.1. Aspects of the Environmental Protection Program included in this report are the assignment of responsibilities to specific EG ampersand G Idaho organizations, a schedule for completion of enhancements, if necessary, and requirements for documentation and reporting. 4 figs., 1 tab

Aircraft vulnerability analysis by modeling and simulation

Science.gov (United States)

Willers, Cornelius J.; Willers, Maria S.; de Waal, Alta

2014-10-01

guidance acceleration and seeker sensitivity. For the purpose of this investigation the aircraft is equipped with conventional pyrotechnic decoy flares and the missile has no counter-countermeasure means (security restrictions on open publication). This complete simulation is used to calculate the missile miss distance, when the missile is launched from different locations around the aircraft. The miss distance data is then graphically presented showing miss distance (aircraft vulnerability) as a function of launch direction and range. The aircraft vulnerability graph accounts for aircraft and missile characteristics, but does not account for missile deployment doctrine. A Bayesian network is constructed to fuse the doctrinal rules with the aircraft vulnerability data. The Bayesian network now provides the capability to evaluate the combined risk of missile launch and aircraft vulnerability. It is shown in this paper that it is indeed possible to predict the aircraft vulnerability to missile attack in a comprehensive modelling and a holistic process. By using the appropriate real-world models, this approach is used to evaluate the effectiveness of specific countermeasure techniques against specific missile threats. The use of a Bayesian network provides the means to fuse simulated performance data with more abstract doctrinal rules to provide a realistic assessment of the aircraft vulnerability.

Aircraft Weather Mitigation for the Next Generation Air Transportation System

Science.gov (United States)

Stough, H. Paul, III

2007-01-01

Atmospheric effects on aviation are described by Mahapatra (1999) as including (1) atmospheric phenomena involving air motion - wind shear and turbulence; (2) hydrometeorological phenomena - rain, snow and hail; (3) aircraft icing; (4) low visibility; and (5) atmospheric electrical phenomena. Aircraft Weather Mitigation includes aircraft systems (e.g. airframe, propulsion, avionics, controls) that can be enacted (by a pilot, automation or hybrid systems) to suppress and/or prepare for the effects of encountered or unavoidable weather or to facilitate a crew operational decision-making process relative to weather. Aircraft weather mitigation can be thought of as a continuum (Figure 1) with the need to avoid all adverse weather at one extreme and the ability to safely operate in all weather conditions at the other extreme. Realistic aircraft capabilities fall somewhere between these two extremes. The capabilities of small general aviation aircraft would be expected to fall closer to the "Avoid All Adverse Weather" point, and the capabilities of large commercial jet transports would fall closer to the "Operate in All Weather Conditions" point. The ability to safely operate in adverse weather conditions is dependent upon the pilot s capabilities (training, total experience and recent experience), the airspace in which the operation is taking place (terrain, navigational aids, traffic separation), the capabilities of the airport (approach guidance, runway and taxiway lighting, availability of air traffic control), as well as the capabilities of the airplane. The level of mitigation may vary depending upon the type of adverse weather. For example, a small general aviation airplane may be equipped to operate "in the clouds" without outside visual references, but not be equipped to prevent airframe ice that could be accreted in those clouds.

Imaged-Based Visual Servo Control for a VTOL Aircraft

Directory of Open Access Journals (Sweden)

Liying Zou

2017-01-01

Full Text Available This paper presents a novel control strategy to force a vertical take-off and landing (VTOL aircraft to accomplish the pinpoint landing task. The control development is based on the image-based visual servoing method and the back-stepping technique; its design differs from the existing methods because the controller maps the image errors onto the actuator space via a visual model which does not contain the depth information of the feature point. The novelty of the proposed method is to extend the image-based visual servoing technique to the VTOL aircraft control. In addition, the Lyapunov theory is used to prove the asymptotic stability of the VTOL aircraft visual servoing system, while the image error can converge to zero. Furthermore, simulations have been also conducted to demonstrate the performances of the proposed method.

B-1 Aircraft Main Hydraulic Pump Tests With MIL-H-87257 Hydraulic Fluid

National Research Council Canada - National Science Library

Sharma, Shashi

1998-01-01

In an effort to convert the B-1 aircraft from MIL-H-5606 to M1-H-87257, the Air Force sponsored a study conducted by Rockwell International from April 1991 through June 1992, under contract F34601-89-C-0401...

Subjective estimates of G-load in centrifuge-based simulation and applications for G-cueing in Desdemona

NARCIS (Netherlands)

Correia Grácio, B.J.; Wentink, M.; Groen, E.; Bles, W.

2009-01-01

In centrifuge simulators pilots experience the G-forces and fast G-onsets encountered in the real fighter aircraft. The motion cueing principle that drives these simulators is based on creating G-forces by increasing the centripetal force of the centrifuge through a rotation of the simulator arm.

The MAP, M/G1,G2/1 queue with preemptive priority

Directory of Open Access Journals (Sweden)

Bong Dae Choi

1997-01-01

Full Text Available We consider the MAP, M/G1,G2/1 queue with preemptive resume priority, where low priority customers arrive to the system according to a Markovian arrival process (MAP and high priority customers according to a Poisson process. The service time density function of low (respectively: high priority customers is g1(x (respectively: g2(x. We use the supplementary variable method with Extended Laplace Transforms to obtain the joint transform of the number of customers in each priority queue, as well as the remaining service time for the customer in service in the steady state. We also derive the probability generating function for the number of customers of low (respectively, high priority in the system just after the service completion epochs for customers of low (respectively, high priority.

Study of V/STOL aircraft implementation. Volume 1: Summary

Science.gov (United States)

Portenier, W. J.; Webb, H. M.

1973-01-01

A high density short haul air market which by 1980 is large enough to support the introduction of an independent short haul air transportation system is discussed. This system will complement the existing air transportation system and will provide relief of noise and congestion problems at conventional airports. The study has found that new aircraft, exploiting V/STOL and quiet engine technology, can be available for implementing these new services, and they can operate from existing reliever and general aviation airports. The study has also found that the major funding requirements for implementing new short haul services could be borne by private capital, and that the government funding requirement would be minimal and/or recovered through the airline ticket tax. In addition, a suitable new short haul aircraft would have a market potential for $3.5 billion in foreign sales. The long lead times needed for aircraft and engine technology development will require timely actions by federal agencies.

14 CFR 61.317 - Is my sport pilot certificate issued with aircraft category and class ratings?

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Is my sport pilot certificate issued with... GROUND INSTRUCTORS Sport Pilots § 61.317 Is my sport pilot certificate issued with aircraft category and class ratings? Your sport pilot certificate does not list aircraft category and class ratings. When you...

Aircraft Anomaly Detection Using Performance Models Trained on Fleet Data

Science.gov (United States)

Gorinevsky, Dimitry; Matthews, Bryan L.; Martin, Rodney

2012-01-01

This paper describes an application of data mining technology called Distributed Fleet Monitoring (DFM) to Flight Operational Quality Assurance (FOQA) data collected from a fleet of commercial aircraft. DFM transforms the data into aircraft performance models, flight-to-flight trends, and individual flight anomalies by fitting a multi-level regression model to the data. The model represents aircraft flight performance and takes into account fixed effects: flight-to-flight and vehicle-to-vehicle variability. The regression parameters include aerodynamic coefficients and other aircraft performance parameters that are usually identified by aircraft manufacturers in flight tests. Using DFM, the multi-terabyte FOQA data set with half-million flights was processed in a few hours. The anomalies found include wrong values of competed variables, (e.g., aircraft weight), sensor failures and baises, failures, biases, and trends in flight actuators. These anomalies were missed by the existing airline monitoring of FOQA data exceedances.

Porcine epidemic diarrhea virus through p53-dependent pathway causes cell cycle arrest in the G0/G1 phase.

Science.gov (United States)

Sun, Pei; Wu, Haoyang; Huang, Jiali; Xu, Ying; Yang, Feng; Zhang, Qi; Xu, Xingang

2018-05-22

Porcine epidemic diarrhea virus (PEDV), an enteropathogenic Alphacoronavirus, has caused enormous economic losses in the swine industry. p53 protein exists in a wide variety of animal cells, which is involved in cell cycle regulation, apoptosis, cell differentiation and other biological functions. In this study, we investigated the effects of PEDV infection on the cell cycle of Vero cells and p53 activation. The results demonstrated that PEDV infection induces cell cycle arrest at G0/G1 phase in Vero cells, while UV-inactivated PEDV does not cause cell cycle arrest. PEDV infection up-regulates the levels of p21, cdc2, cdk2, cdk4, Cyclin A protein and down-regulates Cyclin E protein. Further research results showed that inhibition of p53 signaling pathway can reverse the cell cycle arrest in G0/G1 phase induced by PEDV infection and cancel out the up-regulation of p21 and corresponding Cyclin/cdk mentioned above. In addition, PEDV infection of the cells synchronized in various stages of cell cycle showed that viral subgenomic RNA and virus titer were higher in the cells released from G0/G1 phase synchronized cells than that in the cells released from the G1/S phase and G2/M phase synchronized or asynchronous cells after 18 h p.i.. This is the first report to demonstrate that the p53-dependent pathway plays an important role in PEDV induced cell cycle arrest and beneficially contributes to viral infection. Copyright © 2018 Elsevier B.V. All rights reserved.

Barium ionization mechanisms in the CRRES G-1 and G-11b releases

International Nuclear Information System (INIS)

Hunton, D.E.

1993-01-01

The G-11b chemical release experiment form the Combined Release and Radiation Effects Satellite (CRRES) was conducted in darkness below the solar UV terminator to test the Critical Ionization Velocity (CIV) hypothesis. The Quadrupole Ion Mass Spectrometer (QIMS) aboard CRRES measured fluxes of barium ions from this darkness release that were only a factor of ten smaller than the G-1 release measurements in full sunlight. Possible mechanisms for this significant barium ionization in darkness include CIV, charge exchange with O + , collisional ionization and associative ionization. The authors have evaluated the relative contributions of the collisional mechanisms by constructing a simple model of barium ions from the darkness release seem to be consistent with recent measurements of the charge transfer cross section. A collective plasma ionization mechanism such as CIV does not seem to necessary in order to explain the large barium ion fluxes observed. However, QIMS could only detect barium ions formed several seconds after the initial detonation of the release canister. A CIV process could still have occurred very early in the expansion of the barium neutral cloud and the mass spectrometer would not have detected these ions

Standard Test Method for Preparing Aircraft Cleaning Compounds, Liquid Type, Water Base, for Storage Stability Testing

CERN Document Server

American Society for Testing and Materials. Philadelphia

2002-01-01

1.1 This test method covers the determination of the stability in storage, of liquid, water-base chemical cleaning compounds, used to clean the exterior surfaces of aircraft. 1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

IDENTIFICATION OF AIRCRAFT HAZARDS

International Nuclear Information System (INIS)

K.L. Ashley

2005-01-01

Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in the ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2004, Section 6.4.1). That determination was conservatively based on limited knowledge of flight data in the area of concern and on crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a Monitored Geologic Repository (MGR) at Yucca Mountain using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987, Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. NUREG-0800 is being used here as a reference because some of the same considerations apply. The intended use of this report is to provide inputs for further screening and analysis of the identified aircraft hazards based on the criteria that apply to Category 1 and 2 event sequence analyses as defined in 10 CFR 63.2 (see Section 4). The scope of this technical report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the MGR at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (see Section 7)

Identification of Aircraft Hazards

Energy Technology Data Exchange (ETDEWEB)

K. Ashley

2006-12-08

Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2005 [DIRS 174235], Section 6.4.1). That determination was conservatively based upon limited knowledge of flight data in the area of concern and upon crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a monitored geologic repository (MGR) at Yucca Mountain, using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987 [DIRS 103124], Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. The intended use of this report is to provide inputs for further screening and analysis of identified aircraft hazards based upon the criteria that apply to Category 1 and Category 2 event sequence analyses as defined in 10 CFR 63.2 [DIRS 176544] (Section 4). The scope of this report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the repository at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (Section 7).

Design principles of the yeast G1/S switch.

Directory of Open Access Journals (Sweden)

Xiaojing Yang

2013-10-01

Full Text Available A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are established: phosphorylation of Sic1 on multiple sites is necessary for its destruction, and both the upstream kinase Cln1/2-Cdk1 and the downstream kinase Clb5/6-Cdk1 can phosphorylate Sic1 in vitro with varied specificity, cooperativity, and processivity. However, how the system works as a whole is still controversial due to discrepancies between in vitro, in vivo, and theoretical studies. Here, by monitoring Sic1 destruction in real time in individual cells under various perturbations to the system, we provide a clear picture of how the circuitry functions as a switch in vivo. We show that Cln1/2-Cdk1 sets the proper timing of Sic1 destruction, but does not contribute to its destruction speed; thus, it acts only as a trigger. Sic1's inhibition target Clb5/6-Cdk1 controls the speed of Sic1 destruction through a double-negative feedback loop, ensuring a robust all-or-none transition for Clb5/6-Cdk1 activity. Furthermore, we demonstrate that the degradation of a single-phosphosite mutant of Sic1 is rapid and switch-like, just as the wild-type form. Our mathematical model confirms our understanding of the circuit and demonstrates that the substrate sharing between the two kinases is not a redundancy but a part of the design to overcome the trade-off between the timing and sharpness of Sic1 degradation. Our study provides direct mechanistic insight into the design features underlying the yeast G1/S switch.

DOE standard: Radiological control

International Nuclear Information System (INIS)

1999-07-01

The Department of Energy (DOE) has developed this Standard to assist line managers in meeting their responsibilities for implementing occupational radiological control programs. DOE has established regulatory requirements for occupational radiation protection in Title 10 of the Code of Federal Regulations, Part 835 (10 CFR 835), ''Occupational Radiation Protection''. Failure to comply with these requirements may lead to appropriate enforcement actions as authorized under the Price Anderson Act Amendments (PAAA). While this Standard does not establish requirements, it does restate, paraphrase, or cite many (but not all) of the requirements of 10 CFR 835 and related documents (e.g., occupational safety and health, hazardous materials transportation, and environmental protection standards). Because of the wide range of activities undertaken by DOE and the varying requirements affecting these activities, DOE does not believe that it would be practical or useful to identify and reproduce the entire range of health and safety requirements in this Standard and therefore has not done so. In all cases, DOE cautions the user to review any underlying regulatory and contractual requirements and the primary guidance documents in their original context to ensure that the site program is adequate to ensure continuing compliance with the applicable requirements. To assist its operating entities in achieving and maintaining compliance with the requirements of 10 CFR 835, DOE has established its primary regulatory guidance in the DOE G 441.1 series of Guides. This Standard supplements the DOE G 441.1 series of Guides and serves as a secondary source of guidance for achieving compliance with 10 CFR 835

DOE standard: Radiological control

Energy Technology Data Exchange (ETDEWEB)

1999-07-01

The Department of Energy (DOE) has developed this Standard to assist line managers in meeting their responsibilities for implementing occupational radiological control programs. DOE has established regulatory requirements for occupational radiation protection in Title 10 of the Code of Federal Regulations, Part 835 (10 CFR 835), ``Occupational Radiation Protection``. Failure to comply with these requirements may lead to appropriate enforcement actions as authorized under the Price Anderson Act Amendments (PAAA). While this Standard does not establish requirements, it does restate, paraphrase, or cite many (but not all) of the requirements of 10 CFR 835 and related documents (e.g., occupational safety and health, hazardous materials transportation, and environmental protection standards). Because of the wide range of activities undertaken by DOE and the varying requirements affecting these activities, DOE does not believe that it would be practical or useful to identify and reproduce the entire range of health and safety requirements in this Standard and therefore has not done so. In all cases, DOE cautions the user to review any underlying regulatory and contractual requirements and the primary guidance documents in their original context to ensure that the site program is adequate to ensure continuing compliance with the applicable requirements. To assist its operating entities in achieving and maintaining compliance with the requirements of 10 CFR 835, DOE has established its primary regulatory guidance in the DOE G 441.1 series of Guides. This Standard supplements the DOE G 441.1 series of Guides and serves as a secondary source of guidance for achieving compliance with 10 CFR 835.

REQUIREMENT VERIFICATION AND SYSTEMS ENGINEERING TECHNICAL REVIEW (SETR) ON A COMMERCIAL DERIVATIVE AIRCRAFT (CDA) PROGRAM

Science.gov (United States)

2017-09-01

VERIFICATION AND SYSTEMS ENGINEERING TECHNICAL REVIEW (SETR) ON A COMMERCIAL DERIVATIVE AIRCRAFT (CDA) PROGRAM by Theresa L. Thomas September... ENGINEERING TECHNICAL REVIEW (SETR) ON A COMMERCIAL DERIVATIVE AIRCRAFT (CDA) PROGRAM 5. FUNDING NUMBERS 6. AUTHOR(S) Theresa L. Thomas 7...CODE 13. ABSTRACT (maximum 200 words) The Naval Air Systems Command (NAVAIR) systems engineering technical review (SETR) process does not

14 CFR 49.11 - FAA Aircraft Registry.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA Aircraft Registry. 49.11 Section 49.11... AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for recording, a conveyance must be mailed to the FAA Aircraft Registry, Department of Transportation, Post Office...

Photochemical model evaluation of 2013 California wild fire air quality impacts using surface, aircraft, and satellite data.

Science.gov (United States)

Baker, K R; Woody, M C; Valin, L; Szykman, J; Yates, E L; Iraci, L T; Choi, H D; Soja, A J; Koplitz, S N; Zhou, L; Campuzano-Jost, Pedro; Jimenez, Jose L; Hair, J W

2018-10-01

The Rim Fire was one of the largest wildfires in California history, burning over 250,000 acres during August and September 2013 affecting air quality locally and regionally in the western U.S. Routine surface monitors, remotely sensed data, and aircraft based measurements were used to assess how well the Community Multiscale Air Quality (CMAQ) photochemical grid model applied at 4 and 12 km resolution represented regional plume transport and chemical evolution during this extreme wildland fire episode. Impacts were generally similar at both grid resolutions although notable differences were seen in some secondary pollutants (e.g., formaldehyde and peroxyacyl nitrate) near the Rim fire. The modeling system does well at capturing near-fire to regional scale smoke plume transport compared to remotely sensed aerosol optical depth (AOD) and aircraft transect measurements. Plume rise for the Rim fire was well characterized as the modeled plume top was consistent with remotely sensed data and the altitude of aircraft measurements, which were typically made at the top edge of the plume. Aircraft-based lidar suggests O 3 downwind in the Rim fire plume was vertically stratified and tended to be higher at the plume top, while CMAQ estimated a more uniformly mixed column of O 3 . Predicted wildfire ozone (O 3 ) was overestimated both at the plume top and at nearby rural and urban surface monitors. Photolysis rates were well characterized by the model compared with aircraft measurements meaning aerosol attenuation was reasonably estimated and unlikely contributing to O 3 overestimates at the top of the plume. Organic carbon was underestimated close to the Rim fire compared to aircraft data, but was consistent with nearby surface measurements. Periods of elevated surface PM 2.5 at rural monitors near the Rim fire were not usually coincident with elevated O 3 . Published by Elsevier B.V.

Determination of tricresyl phosphate air contamination in aircraft.

Science.gov (United States)

Denola, G; Hanhela, P J; Mazurek, W

2011-08-01

Monitoring of tricresyl phosphate (TCP) contamination of cockpit air was undertaken in three types of military aircraft [fighter trainer (FT), fighter bomber (FB), and cargo transport (CT) aircraft]. The aircraft had a previous history of pilot complaints about cockpit air contamination suspected to originate from the engine bleed air supply through the entry of aircraft turbine engine oil (ATO) into the engine compressor. Air samples were collected in flight and on the ground during engine runs using sorbent tubes packed with Porapak Q and cellulose filters. A total of 78 air samples were analysed, from 46 different aircraft, and 48 samples were found to be below the limit of detection. Nine incidents of smoke/odour were identified during the study. The concentrations of toxic o-cresyl phosphate isomers were below the level of detection in all samples. The highest total TCP concentration was 51.3 μg m(-3), while most were generally found to be contamination of cabin/cockpit air has been the subject of much concern in aviation, quantitative data are sparse.

8 CFR 1280.21 - Seizure of aircraft.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Seizure of aircraft. 1280.21 Section 1280... REGULATIONS IMPOSITION AND COLLECTION OF FINES § 1280.21 Seizure of aircraft. Seizure of an aircraft under the... that its value is less than the amount of the fine which may be imposed. If seizure of an aircraft for...

8 CFR 280.21 - Seizure of aircraft.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Seizure of aircraft. 280.21 Section 280.21... OF FINES § 280.21 Seizure of aircraft. Seizure of an aircraft under the authority of section 239 of... than the amount of the fine which may be imposed. If seizure of an aircraft for violation of section...

Aircraft gas turbines

Energy Technology Data Exchange (ETDEWEB)

Arai, M [Kawasaki Heavy Industries Ltd., Kobe (Japan)

1995-03-01

Recently the international relationship has been playing an important role in the research, development and production of the aircraft gas turbine. The YSX, which is supposed to be the 100-seat class commercial aircraft, has been planned by Japan Aircraft Development (JADC) as an international cooperative project. Recently many western aeroengine companies have offered the collaboration of small turbofan engines which would be installed on YSX to Japanese aeroengine companies (IHI, KHI and MHI). The YSX is powered by 16,000-20,000 1bs thrust class engines. As for medium turbofan engine (V2500), the V 2500 family of 22,000 to 30,000 1bs thrust has been developed since 1983 through international collaboration by seven aeroengine companies in five nations. In this paper, the recent Japan`s activities of the research, development and production with viewing the world-wide movement, are described. 6 figs.

Cessna Citation X Business Aircraft Eigenvalue Stability– Part 1: a New GUI for the LFRs Generation

Directory of Open Access Journals (Sweden)

Yamina BOUGHARI

2017-12-01

Full Text Available The aim of “Robustness Analysis” is to assess aircraft stability in the presence of all admissible uncertainties. Models that are able to describe the aircraft dynamics by taking into account all uncertainties over a region inside the flight envelope have therefore been developed, using Linear Fractional Representation (LFR. In this paper Part 1 a friendly Graphical User Interface is developed to facilitate the generation of Linear Fractional Representation uncertainty models for the Cessna Citation X aircraft using 12 weight and Xcg configurations; thus, 26 regions of the flight envelope are developed for different Weight/ Xcg configurations to study the aircraft’s longitudinal motion. In the aim to analyzed the robustness stability of Cessna Citation X in Part 2 using the Graphical User Interface developed in the Clearance Of Flight Control Laws Using Optimization (COFCLUO project. This project aimed to boost the aircraft safety using computer computation.

Aircraft Nuclear Propulsion Program: Quarterly Progress Report for Period Ending December 31, 1956, Part 1 - 5

Energy Technology Data Exchange (ETDEWEB)

Jordan, W. H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cramer, S. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Miller, A. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

1957-03-12

This quarterly progress report of the Aircraft Nuclear Propulsion Project at ORNL records the technical progress of the research on circulating-fuel reactors and other ANP research at the Laboratory under its Contract W-7405-eng-26. The report is divided into five major parts: 1. Aircraft Reactor Engineering, 2. Chemistry, 3. Metallurgy, 4. Heat Transfer and Physical Properties, Radiation Damage, and Fuel Recovery and Reprocessing, and 5. Reactor Shielding. The ANP Project is comprised of about 550 technical and scientific personnel engaged in many phases of research directed toward the achievement of nuclear propulsion of aircraft. A considerable portion of this research is performed in support of the work of other organizations participating in the national ANP effort. However, the bulk of the ANP research at ORNL is directed toward the development of a circulating-fuel type of reactor. The design, construction, and operation of the Aircraft Reactor Test (ART), with the cooperation of the Pratt & Whitney Aircraft Division, are the current objectives of the project. The ART is to be a power plant system that will include a 60-Mw circulating fuel reflector-moderator reactor and adequate means for heat disposal. Operation of the system will be for the purpose of determining feasibility and for studying the problems associated with the design, construction, and operation of a high-power circulating-fuel refIector-moderated aircraft reactor system.

Aircraft and background noise annoyance effects

Science.gov (United States)

Willshire, K. F.

1984-01-01

To investigate annoyance of multiple noise sources, two experiments were conducted. The first experiment, which used 48 subjects, was designed to establish annoyance-noise level functions for three community noise sources presented individually: jet aircraft flyovers, air conditioner, and traffic. The second experiment, which used 216 subjects, investigated the effects of background noise on aircraft annoyance as a function of noise level and spectrum shape; and the differences between overall, aircraft, and background noise annoyance. In both experiments, rated annoyance was the dependent measure. Results indicate that the slope of the linear relationship between annoyance and noise level for traffic is significantly different from that of flyover and air conditioner noise and that further research was justified to determine the influence of the two background noises on overall, aircraft, and background noise annoyance (e.g., experiment two). In experiment two, total noise exposure, signal-to-noise ratio, and background source type were found to have effects on all three types of annoyance. Thus, both signal-to-noise ratio, and the background source must be considered when trying to determine community response to combined noise sources.

Activities of NASA's Global Modeling Initiative (GMI) in the Assessment of Subsonic Aircraft Impact

Science.gov (United States)

Rodriquez, J. M.; Logan, J. A.; Rotman, D. A.; Bergmann, D. J.; Baughcum, S. L.; Friedl, R. R.; Anderson, D. E.

2004-01-01

The Intergovernmental Panel on Climate Change estimated a peak increase in ozone ranging from 7-12 ppbv (zonal and annual average, and relative to a baseline with no aircraft), due to the subsonic aircraft in the year 2015, corresponding to aircraft emissions of 1.3 TgN/year. This range of values presumably reflects differences in model input (e.g., chemical mechanism, ground emission fluxes, and meteorological fields), and algorithms. The model implemented by the Global Modeling Initiative allows testing the impact of individual model components on the assessment calculations. We present results of the impact of doubling the 1995 aircraft emissions of NOx, corresponding to an extra 0.56 TgN/year, utilizing meteorological data from NASA's Data Assimilation Office (DAO), the Goddard Institute for Space Studies (GISS), and the Middle Atmosphere Community Climate Model, version 3 (MACCM3). Comparison of results to observations can be used to assess the model performance. Peak ozone perturbations ranging from 1.7 to 2.2 ppbv of ozone are calculated using the different fields. These correspond to increases in total tropospheric ozone ranging from 3.3 to 4.1 Tg/Os. These perturbations are consistent with the IPCC results, due to the difference in aircraft emissions. However, the range of values calculated is much smaller than in IPCC.

Evaluation of the hemoglobin A1c-analyzer TOSOH HLC-723 G7.

Science.gov (United States)

Gremmels, Heinz-Detlef; Richter, Anja; Watzke, Ivonne

2003-01-01

The TOSOH HLC-723 G7 is a compact analyzer designed for the measurement of HbA1c under routine laboratory conditions. The analyzer has an automatic blood tube supply and positive sample identification. Samples are transported automatically via racks in a continuous-load mode, cap piercing is optional. Tests devoted to the assessment of reproducibility and accuracy of analytical results indicated that over a test period of 17 days, the intra-assay variation (CV) was 1.79%, and the inter-assay variation 2.60%, respectively. A comparison with the predecessor model G5 showed a very good correlation (r = 0.997, y = 1.0041x - 0.00172; n = 149). The presence of high triglyceride, bilirubin or urea concentrations in patient samples did not influence the analytical precision. The labile HbA1c fraction (L-A1c) is clearly separated during chromatography and thus does not compromise HbA1c analysis. With a protocol of 1.2 minutes, the TOSOH G7 is a very fast analyzer, designed for laboratories with a high throughput of samples.

Application and expression of HSV gG1 protein from a recombinant strain.

Science.gov (United States)

Yan, Hua; Yan, Huishen; Huang, Tao; Li, Guocai; Gong, Weijuan; Jiao, Hongmei; Chen, Hongju; Ji, Mingchun

2010-11-01

According to the homologous sequence of glycoprotein G1 (gG1) genes from different strains of herpes simplex virus type 1 (HSV-1), a pair of primers was designed to amplify the gG1 gene fragment by PCR. Both the PCR product and the pGEX-4T-1 vector were digested with EcoR I and Sal I. The gG1 gene fragment was subcloned into the digested pGEX-4T-1 vector to construct a recombinant plasmid (pGEX-4T-1-gG1). The resultant plasmid was identified by dual-enzyme digestion and sequence analysis, and then transformed into Escherichia coli BL21 for expression under the induction of isopropyl β-D-1-thiogalactoside (IPTG). The expressed GST-gG1 fragment was detected by SDS-PAGE and purified by affinity chromatography. The properties of GST-gG1 fragment were evaluated by immunoblot analysis. Enzyme-linked immunosorbent assays (ELISAs) based on the GST-gG1 fragment were used for determining IgG or IgM to HSV-1. The GST-gG1 fragment-specific ELISA was also compared with ELISA with whole-HSV-1 antigen and commercial ELISA kits. The gG1-specific IgG and IFN-γ producing CD8+ T cells were induced in mice immunized with the GST-gG1 fragment. These results indicated that the GST-gG1 fragment could be used for replacing whole-virus antigen to detect IgM and IgG to HSV-1 in human sera, which provided a strategy for developing vaccines to protect HSV-1 infection using gG1 fragment. Copyright © 2010 Elsevier B.V. All rights reserved.

Structural Integrity Assessment of Reactor Containment Subjected to Aircraft Crash

International Nuclear Information System (INIS)

Kim, Junyong; Chang, Yoonsuk

2013-01-01

When an accident occurs at the NPP, containment building which acts as the last barrier should be assessed and analyzed structural integrity by internal loading or external loading. On many occasions that can occur in the containment internal such as LOCA(Loss Of Coolant Accident) are already reflected to design. Likewise, there are several kinds of accidents that may occur from the outside of containment such as earthquakes, hurricanes and strong wind. However, aircraft crash that at outside of containment is not reflected yet in domestic because NPP sites have been selected based on the probabilistic method. After intentional aircraft crash such as World Trade Center and Pentagon accident in US, social awareness for safety of infrastructure like NPP was raised world widely and it is time for assessment of aircraft crash in domestic. The object of this paper is assessment of reactor containment subjected to aircraft crash by FEM(Finite Element Method). In this paper, assessment of structural integrity of containment building subjected to certain aircraft crash was carried out. Verification of structure integrity of containment by intentional severe accident. Maximum stress 61.21MPa of horizontal shell crash does not penetrate containment. Research for more realistic results needed by steel reinforced concrete model

Thermal comfort assessment in civil aircraft cabins

Directory of Open Access Journals (Sweden)

Pang Liping

2014-04-01

Full Text Available Aircraft passengers are more and demanding in terms of thermal comfort. But it is not yet easy for aircraft crew to control the environment control system (ECS that satisfies the thermal comfort for most passengers due to a number of causes. This paper adopts a corrected predicted mean vote (PMV model and an adaptive model to assess the thermal comfort conditions for 31 investigated flights and draws the conclusion that there does exist an uncomfortable thermal phenomenon in civil aircraft cabins, especially in some short-haul continental flights. It is necessary to develop an easy way to predict the thermal sensation of passengers and to direct the crew to control ECS. Due to the assessment consistency of the corrected PMV model and the adaptive model, the adaptive model of thermal neutrality temperature can be used as a method to predict the cabin optimal operative temperature. Because only the mean outdoor effective temperature ET∗ of a departure city is an input variable for the adaptive model, this method can be easily understood and implemented by the crew and can satisfy 80–90% of the thermal acceptability levels of passengers.

Aircraft Cabin Environmental Quality Sensors

Energy Technology Data Exchange (ETDEWEB)

Gundel, Lara; Kirchstetter, Thomas; Spears, Michael; Sullivan, Douglas

2010-05-06

The Indoor Environment Department at Lawrence Berkeley National Laboratory (LBNL) teamed with seven universities to participate in a Federal Aviation Administration (FAA) Center of Excellence (COE) for research on environmental quality in aircraft. This report describes research performed at LBNL on selecting and evaluating sensors for monitoring environmental quality in aircraft cabins, as part of Project 7 of the FAA's COE for Airliner Cabin Environmental Research (ACER)1 effort. This part of Project 7 links to the ozone, pesticide, and incident projects for data collection and monitoring and is a component of a broader research effort on sensors by ACER. Results from UCB and LBNL's concurrent research on ozone (ACER Project 1) are found in Weschler et al., 2007; Bhangar et al. 2008; Coleman et al., 2008 and Strom-Tejsen et al., 2008. LBNL's research on pesticides (ACER Project 2) in airliner cabins is described in Maddalena and McKone (2008). This report focused on the sensors needed for normal contaminants and conditions in aircraft. The results are intended to complement and coordinate with results from other ACER members who concentrated primarily on (a) sensors for chemical and biological pollutants that might be released intentionally in aircraft; (b) integration of sensor systems; and (c) optimal location of sensors within aircraft. The parameters and sensors were selected primarily to satisfy routine monitoring needs for contaminants and conditions that commonly occur in aircraft. However, such sensor systems can also be incorporated into research programs on environmental quality in aircraft cabins.

NDT applications in the aircraft industry

International Nuclear Information System (INIS)

Aguilar, E.C.

1994-01-01

Non-destructive testing (NDT) in the aircraft industry is used primarily to detect process defects in the manufacturing stage and failure defects in the in-service stage. Inspection techniques such as X- or gamma ray radiography are used for examination. Eddy current and ultrasonic are applied for examination, fluorescent penetrant and magnetic particles are applied for examination of aircraft and engine. With the wide scope of application, this paper discussed one type of NDT that is much used in aircraft being the latest technique in aircraft manufacturing. 1 fig

Low Energy Nuclear Reaction Aircraft- 2013 ARMD Seedling Fund Phase I Project

Science.gov (United States)

Wells, Douglas P.; McDonald, Robert; Campbell, Robbie; Chase, Adam; Daniel, Jason; Darling, Michael; Green, Clayton; MacGregor, Collin; Sudak, Peter; Sykes, Harrison;

More electric aircraft starter-generator system with utilization of hybrid modulated model predictive control

OpenAIRE

Yoeh, Seang Shen; Yang, Tao; Tarisciotti, Luca; Hill, Christopher Ian; Bozhko, Serhiy

2016-01-01

The current trend for future aircraft is the adoption of the More Electric Aircraft (MEA) concept. The electrical based starter-generator (S/G) system is one of the core ideas from the MEA concept. The PI based control scheme has been investigated in various papers for the permanent magnet based S/G system. Different control schemes are to be considered to improve the control performance of the S/G system. A type of non-linear control called Model Predictive Control (MPC) is considered for it...

Study of fuel systems for LH2-fueled subsonic transport aircraft, volume 1

Science.gov (United States)

Brewer, G. D.; Morris, R. E.; Davis, G. W.; Versaw, E. F.; Cunnington, G. R., Jr.; Riple, J. C.; Baerst, C. F.; Garmong, G.

1978-01-01

Several engine concepts examined to determine a preferred design which most effectively exploits the characteristics of hydrogen fuel in aircraft tanks received major emphasis. Many candidate designs of tank structure and cryogenic insulation systems were evaluated. Designs of all major elements of the aircraft fuel system including pumps, lines, valves, regulators, and heat exchangers received attention. Selected designs of boost pumps to be mounted in the LH2 tanks, and of a high pressure pump to be mounted on the engine were defined. A final design of LH2-fueled transport aircraft was established which incorporates a preferred design of fuel system. That aircraft was then compared with a conventionally fueled counterpart designed to equivalent technology standards.

Critical joints in large composite primary aircraft structures. Volume 1: Technical summary

Science.gov (United States)

Bunin, Bruce L.

1985-01-01

A program was conducted at Douglas Aircraft Company to develop the technology for critical joints in composite wing structure that meets all the design requirements of a 1990 commercial transport aircraft. In fulfilling this objective, analytical procedures for joint design and analysis were developed during Phase 1 of the program. Tests were conducted at the element level to supply the empirical data required for methods development. Large composite multirow joints were tested to verify the selected design concepts and for correlation with analysis predictions. The Phase 2 program included additional tests to provide joint design and analysis data, and culminated with several technology demonstration tests of a major joint area representative of a commercial transport wing. The technology demonstration program of Phase 2 is discussed. The analysis methodology development, structural test program, and correlation between test results and analytical strength predictions are reviewed.

Acoustical design economic trade off for transport aircraft

Science.gov (United States)

Benito, A.

The effects of ICAO fixed certification limits and local ordinances on acoustic emissions from jets on commercial transport aircraft and costs of operations are explored. The regulations effectively ban some aircraft from operation over populated areas, impose curfews on airports and, in conjunction with local civil aviation rules, levy extra taxes and quotas on noisier equipment. Jet engine manufacturers have attempted to increase the flow laminarity, decrease the exhaust speed and develop acoustic liners for selected duct areas. Retrofits are, however, not usually cost effective due to increased operational costs, e.g., fuel consumption can increase after engine modification because of increased weight. Finally, an attempt is made to assess, monetarily, the costs of noise pollution, wherein fines are levied for noisy aircraft and the money is spent insulating homes from noise.

Pilot Designed Aircraft Displays in General Aviation: An Exploratory Study and Analysis

Science.gov (United States)

Conaway, Cody R.

From 2001-2011, the General Aviation (GA) fatal accident rate remained unchanged (Duquette & Dorr, 2014) with an overall stagnant accident rate between 2004 and 2013. The leading cause, loss of control in flight (NTSB, 2015b & 2015c) due to pilot inability to recognize approach to stall/spin conditions (NTSB, 2015b & 2016b). In 2013, there were 1,224 GA accidents in the U.S., accounting for 94% of all U.S. aviation accidents and 90% of all U.S. aviation fatalities that year (NTSB, 2015c). Aviation entails multiple challenges for pilots related to task management, procedural errors, perceptual distortions, and cognitive discrepancies. While machine errors in airplanes have continued to decrease over the years, human error still has not (NTSB, 2013). A preliminary analysis of a PC-based, Garmin G1000 flight deck was conducted with 3 professional pilots. Analyses revealed increased task load, opportunities for distraction, confusing perceptual ques, and hindered cognitive performance. Complex usage problems were deeply ingrained in the functionality of the system, forcing pilots to use fallible work arounds, add unnecessary steps, and memorize knob turns or button pushes. Modern computing now has the potential to free GA cockpit designs from knobs, soft keys, or limited display options. Dynamic digital displays might include changes in instrumentation or menu structuring depending on the phase of flight. Airspeed indicators could increase in size to become more salient during landing, simultaneously highlighting pitch angle on Attitude Indicators and automatically decluttering unnecessary information for landing. Likewise, Angle-of-Attack indicators demonstrate a great safety and performance advantage for pilots (Duquette & Dorr, 2014; NTSB, 2015b & 2016b), an instrument typically found in military platforms and now the Icon A5, light-sport aircraft (Icon, 2016). How does the design of pilots' environment---the cockpit---further influence their efficiency and

14 CFR 47.19 - FAA Aircraft Registry.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA Aircraft Registry. 47.19 Section 47.19... REGISTRATION General § 47.19 FAA Aircraft Registry. Each application, request, notification, or other communication sent to the FAA under this Part must be mailed to the FAA Aircraft Registry, Department of...

TECHNICAL EFFICIENCY AND TECHNICAL LEVEL INDICATORS APPLICATION FOR CIVIL AIRCRAFT FUNCTIONAL PROPERTIES ANALYSIS

Directory of Open Access Journals (Sweden)

Vadim V. Efimov

2018-01-01

Full Text Available Functional properties characterize the purpose of the aircraft and are described by its flight performance characteristics such as range and cruising speed, payload, runway characteristics, etc. Functional properties also characterize the aircraft efficiency that determines the objective need for their analysis by both aircraft designers and operators in conditions of permanent and systematic efficiency increase necessity. When choosing the aircraft, it is important for the operator to make sure that a selected aircraft type has a high level of functional properties, which will allow it to provide high operational efficiency without obsolescence in the long term. However, when choosing from several aircraft types the operator has to face the fact that some characteristics of considered aircraft variants are better and the others are worse that does not allow to definitely determine what aircraft type has a higher level of functional properties.The possibility of applying technical efficiency indicators and a generalized technical level indicator for analyzing the functional properties of civil aviation aircraft is explored in this article. Fuel, weight and target efficiency values as well as the previously improved technical level indicator value were calculated for the different generations and modifications of Boeing 737 and Airbus A320 families of medium-range airplanes, which was followed by the results interpretation within one airplane generation and when moving historically from one airplane generation to another. According to analysis results it is concluded that it is impossible to define the change of the aircraft functional properties level by the change in the values of separate technical efficiency indicators. Thus, it is proposed to use a generalized technical level indicator that determines the level of aircraft technical perfection for purpose and to use efficiency indicators to analyze the cost of providing this level of

4G/5G polymorphism modulates PAI-1 circulating levels in obese women.

Science.gov (United States)

Fernandes, Karla S; Sandrim, Valéria C

2012-05-01

The increase in plasminogen activator inhibitor type 1 (PAI-1) has been described as a risk factor to thrombosis-related diseases. In addition, it has been demonstrated that the variant 4G of polymorphism 4G/5G located in promoter region of PAI-1 gene is associated with higher PAI-1 levels. We investigate the role of this polymorphism on circulating PAI-1 concentration in a population of 57 obese women (23%, 4G/4G; 49%, 4G/5G and 28%, 5G/5G genotypes). Our results demonstrate a genotype-specific modulation on PAI-1 levels in obese women, thus 5G/5G genotype presented significantly lower levels of plasma PAI-1 when compared to 4G/4G group (46 ± 19 ng/mL vs. 63 ± 13 ng/mL, respectively). Our findings indicate that obese carriers of 4G/4G genotype may have increased risk to develop thrombotic diseases.

A Condition Based Maintenance Approach to Forecasting B-1 Aircraft Parts

Science.gov (United States)

2017-03-23

Air Force Institute of Technology AFIT Scholar Theses and Dissertations 3-23-2017 A Condition Based Maintenance Approach to Forecasting B-1 Aircraft...component’s life history where reliability forecasts could be stipulated based on a component’s current condition . One of the major issues their report noted...Engine Condition Monitoring System Specification. Contract Number DOT-CG-80513-A. Grand Prairie, TX. Air Force Materiel Command. (2011) Requirements For

Pollution reduction technology program for small jet aircraft engines: Class T1

Science.gov (United States)

Bruce, T. W.; Davis, F. G.; Mongia, H. C.

1977-01-01

Small jet aircraft engines (EPA class T1, turbojet and turbofan engines of less than 35.6 kN thrust) were evaluated with the objective of attaining emissions reduction consistent with performance constraints. Configurations employing the technological advances were screened and developed through full scale rig testing. The most promising approaches in full-scale engine testing were evaluated.

Advanced technology composite aircraft structures

Science.gov (United States)

Ilcewicz, Larry B.; Walker, Thomas H.

1991-01-01

Work performed during the 25th month on NAS1-18889, Advanced Technology Composite Aircraft Structures, is summarized. The main objective of this program is to develop an integrated technology and demonstrate a confidence level that permits the cost- and weight-effective use of advanced composite materials in primary structures of future aircraft with the emphasis on pressurized fuselages. The period from 1-31 May 1991 is covered.

The design of nuclear power plants in the Federal Republic of Germany as regards aircraft accidents

International Nuclear Information System (INIS)

Anon.

1978-01-01

On the basis of investigation results of aircraft crashes for the Federal territory and site assessment data of the Ministry of the Interior, air traffic does not present a notable hazard for a nuclear power plant. As a precautionary measure for reducing the remaining risk, design requirements for LWRs were developed which, independently of existing aircraft types, contain mainly an abstract predetermination of an idealized impact load - time diagramme. (HP) [de

Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.

Science.gov (United States)

Pei, Xin-Yan; Dai, Yun; Youssefian, Leena E; Chen, Shuang; Bodie, Wesley W; Takabatake, Yukie; Felthousen, Jessica; Almenara, Jorge A; Kramer, Lora B; Dent, Paul; Grant, Steven

2011-11-10

Effects of Chk1 and MEK1/2 inhibition were investigated in cytokinetically quiescent multiple myeloma (MM) and primary CD138(+) cells. Coexposure to the Chk1 and MEK1/2 inhibitors AZD7762 and selumetinib (AZD6244) robustly induced apoptosis in various MM cells and CD138(+) primary samples, but spared normal CD138(-) and CD34(+) cells. Furthermore, Chk1/MEK1/2 inhibitor treatment of asynchronized cells induced G(0)/G(1) arrest and increased apoptosis in all cell-cycle phases, including G(0)/G(1). To determine whether this regimen is active against quiescent G(0)/G(1) MM cells, cells were cultured in low-serum medium to enrich the G(0)/G(1) population. G(0)/G(1)-enriched cells exhibited diminished sensitivity to conventional agents (eg, Taxol and VP-16) but significantly increased susceptibility to Chk1 ± MEK1/2 inhibitors or Chk1 shRNA knock-down. These events were associated with increased γH2A.X expression/foci formation and Bim up-regulation, whereas Bim shRNA knock-down markedly attenuated lethality. Immunofluorescent analysis of G(0)/G(1)-enriched or primary MM cells demonstrated colocalization of activated caspase-3 and the quiescent (G(0)) marker statin, a nuclear envelope protein. Finally, Chk1/MEK1/2 inhibition increased cell death in the Hoechst-positive (Hst(+)), low pyronin Y (PY)-staining (2N Hst(+)/PY(-)) G(0) population and in sorted small side-population (SSP) MM cells. These findings provide evidence that cytokinetically quiescent MM cells are highly susceptible to simultaneous Chk1 and MEK1/2 inhibition.

N+3 Aircraft Concept Designs and Trade Studies. Volume 1

Science.gov (United States)

Greitzer, E. M.; Bonnefoy, P. A.; DelaRosaBlanco, E.; Dorbian, C. S.; Drela, M.; Hall, D. K.; Hansman, R. J.; Hileman, J. I.; Liebeck, R. H.; Levegren, J.;

Plasminogen Activator Inhibitor-1 (PAI-1) gene 4G/5G alleles frequency distribution in the Lebanese population.

Science.gov (United States)

Shammaa, Dina M R; Sabbagh, Amira S; Taher, Ali T; Zaatari, Ghazi S; Mahfouz, Rami A R

2008-09-01

Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis. Increased plasma PAI-1 levels play an essential role in the pathogenesis of cardiovascular risk and other diseases associated with thrombosis. The 4G/5G polymorphism of the PAI-1 promoter region has been extensively studied in different populations. We studied 160 healthy unrelated Lebanese individuals using a reverse hybridization PCR assay to detect the 5G/5G, 4G/5G and, 4G/4G genotypes of the PAI-1 gene and the frequencies of the 4G and 5G alleles. We found that 4G/5G genotype was the most prevalent (45.6%) followed by 5G/5G (36.9%) and 4G/4G (17.5%). The frequencies of the 4G and 5G alleles were calculated to be 0.403 and 0.597, respectively. Compared to other ethnic communities, the Lebanese population was found to harbour a relatively high prevalence of the rare 4G allele. This, in turn, may predispose this population to develop cardiovascular diseases and other thrombotic clinical conditions. This study aids to enhance our understanding of the genetic features of the Lebanese population.

SigG Does Not Control Gene Expression in Response to DNA Damage in Mycobacterium tuberculosis H37Rv ▿ §

OpenAIRE

Smollett, Katherine L.; Dawson, Lisa F.; Davis, Elaine O.

2010-01-01

Expression of the Mycobacterium tuberculosis sigG sigma factor was induced by a variety of DNA-damaging agents, but inactivation of sigG did not affect induction of gene expression or bacterial survival under these conditions. Therefore, SigG does not control the DNA repair response of M. tuberculosis H37Rv.

Application of AI methods to aircraft guidance and control

Science.gov (United States)

Hueschen, Richard M.; Mcmanus, John W.

1988-01-01

A research program for integrating artificial intelligence (AI) techniques with tools and methods used for aircraft flight control system design, development, and implementation is discussed. The application of the AI methods for the development and implementation of the logic software which operates with the control mode panel (CMP) of an aircraft is presented. The CMP is the pilot control panel for the automatic flight control system of a commercial-type research aircraft of Langley Research Center's Advanced Transport Operating Systems (ATOPS) program. A mouse-driven color-display emulation of the CMP, which was developed with AI methods and used to test the AI software logic implementation, is discussed. The operation of the CMP was enhanced with the addition of a display which was quickly developed with AI methods. The display advises the pilot of conditions not satisfied when a mode does not arm or engage. The implementation of the CMP software logic has shown that the time required to develop, implement, and modify software systems can be significantly reduced with the use of the AI methods.

A New Approach to Modeling the Cost of Ownership for Aircraft Systems.

Science.gov (United States)

1981-08-01

expensive airborne missiles (e.g., Maverick, SRAM ) are funded in separate program elements of their own. If an aircraft system generates requirements for...PNTS b-I p,y,b,u EIR -u p9Y RTOK (FH/MO)QPA pUF PREPGNp ( - DCR) ) BUE b pp PGEN~)~1b-I ~ SER. = SEt. SEF j J,y j CIDM - CIDMP + CIDME + CIDMEI

77 FR 33083 - Airworthiness Directives; WACO Classic Aircraft Corporation Airplanes

Science.gov (United States)

2012-06-05

... Airworthiness Directives; WACO Classic Aircraft Corporation Airplanes AGENCY: Federal Aviation Administration... directive (AD) for certain WACO Classic Aircraft Corporation Models 2T-1A, 2T-1A-1, and 2T-1A-2 airplanes... information identified in this AD, contact WACO Classic Aircraft Corporation; 15955 South Airport Rd., Battle...

The plasminogen activator inhibitor-1 (PAI-1) gene -844 A/G and -675 4G/5G promoter polymorphism significantly influences plasma PAI-1 levels in women with polycystic ovary syndrome.

Science.gov (United States)

Lin, Sun; Huiya, Zhang; Bo, Liu; Wei, Wei; Yongmei, Guan

2009-12-01

Mutations in the plasminogen activator inhibitor-1 (PAI-1) gene, along with increased PAI-1 levels, have been implicated in the pathogenesis of polycystic ovarian syndrome (PCOS). We investigated a possible influence of the promoter polymorphism (-844 A/G and -675 4G/5G) in the PAI-1 gene on plasma PAI-1 levels in 126 PCOS patients and 97 healthy controls. Levels of total testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), fasting plasma glucose (FPG), fasting insulin, and PAI-1 were measured, and body mass index (BMI), waist-to-hip ratio (WHR), LH/FSH ratio, and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. PAI-1 -675 4G/5G and -844 A/G gene polymorphisms were also performed. Total testosterone, fasting insulin, and PAI-1 levels; BMI, LH/FSH, and HOMA-IR were significantly higher in PCOS patients than controls (P 5G or 5G/5G genotype. The plasma PAI-1 levels of the combination of the PAI-1 -844 A/A and -675 4G/4G or 4G/5G genotypes, or the coadunation of 4G/4G and -844 non-G/G (A/A + A/G) genotypes were significantly high in PCOS women compared with controls. A trend to a positive interaction between PAI-1 -675 4G/5G and -844 A/G gene polymorphism may elevate plasma PAI-1 levels and hypofibrinolysis, which is probably an important hereditary risk factor in PCOS.

Biodegradation of international jet A-1 aviation fuel by microorganisms isolated from aircraft tank and joint hydrant storage systems.

Science.gov (United States)

Itah, A Y; Brooks, A A; Ogar, B O; Okure, A B

2009-09-01

Microorganisms contaminating international Jet A-1 aircraft fuel and fuel preserved in Joint Hydrant Storage Tank (JHST) were isolated, characterized and identified. The isolates were Bacillus subtillis, Bacillus megaterium, Flavobacterium oderatum, Sarcina flava, Micrococcus varians, Pseudomonas aeruginosa, Bacillus licheniformis, Bacillus cereus and Bacillus brevis. Others included Candida tropicalis, Candida albicans, Saccharomyces estuari, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Aspergillus flavus, Aspergillus niger, Aspergillus fumigatus, Cladosporium resinae, Penicillium citrinum and Penicillium frequentans. The viable plate count of microorganisms in the Aircraft Tank ranged from 1.3 (+/-0.01) x 104 cfu/mL to 2.2 (+/-1.6) x 104 cfu/mL for bacteria and 102 cfu/mL to 1.68 (+/-0.32) x 103 cfu/mL for fungi. Total bacterial counts of 1.79 (+/-0.2) x 104 cfu/mL to 2.58 (+/-0.04) x 104 cfu/mL and total fungal count of 2.1 (+/-0.1) x 103 cfu/mL to 2.28 (+/-0.5) x 103 cfu/mL were obtained for JHST. Selected isolates were re-inoculated into filter sterilized aircraft fuels and biodegradation studies carried out. After 14 days incubation, Cladosporium resinae exhibited the highest degradation rate with a percentage weight loss of 66 followed by Candida albicans (60.6) while Penicillium citrinum was the least degrader with a weight loss of 41.6%. The ability of the isolates to utilize the fuel as their sole source of carbon and energy was examined and found to vary in growth profile between the isolates. The results imply that aviation fuel could be biodegraded by hydrocarbonoclastic microorganisms. To avert a possible deterioration of fuel quality during storage, fuel pipe clogging and failure, engine component damage, wing tank corrosion and aircraft disaster, efficient routine monitoring of aircraft fuel systems is advocated.

PROBLEMS OF FLIGHT PERSONNEL PREPARATION FOR MODERN AIRCRAFTS

Directory of Open Access Journals (Sweden)

B. Харченко

2011-04-01

Full Text Available At present, the problem who can and who should solve the question concerning the preparationand recurrent training of pilots of Ukrainian civil aviation is not solved. The necessity of updatingof aircraft’s park in aviation branch and aircraft operation, which was ripened 10 years ago,demands a corresponding infrastructure. It is necessary to understand, that the pilots ready toperform the flights on modern aircrafts, will not appear by themselves, therefore the real actions onmodernization of existing system of aircrew and the aviation personnel preparation as a whole arerequired. Main objective of this work is the determination of the basic components concerning thesolving of the problematic questions on preparation of aircrew on modern types of aircrafts. Duringthe problem analysis it was specified that the present development of system of aircrew preparationin Ukraine is not perfect, and does not correspond the ICAO and EU requirements, therefore needsan immediate intervention at the highest State level. Trainings are not complex, as do not containthe elements of selection of aircrew members cooperation. Programs of recurrent training ofaircrew, courses of pilots training flight preparation were not reconsidered for many years

Irradiated graphite studies prior to decommissioning of G1, G2 and G3 reactors

International Nuclear Information System (INIS)

Bonal, J.P.; Vistoli, J.Ph.; Combes, C.

2005-01-01

G1 (46 MW th ), G2 (250 MW th ) and G3 (250 MW th ) are the first French plutonium production reactors owned by CEA (Commissariat a l'Energie Atomique). They started to be operated in 1956 (G1), 1959 (G2) and 1960 (G3); their final shutdown occurred in 1968, 1980 and 1984 respectively. Each reactor used about 1200 tons of graphite as moderator, moreover in G2 and G3, a 95 tons graphite wall is used to shield the rear side concrete from neutron irradiation. G1 is an air cooled reactor operated at a graphite temperature ranging from 30 C to 230 C; G2 and G3 are CO 2 cooled reactors and during operation the graphite temperature is higher (140 C to 400 C). These reactors are now partly decommissioned, but the graphite stacks are still inside the reactors. The graphite core radioactivity has decreased enough so that a full decommissioning stage may be considered. Conceming this decommissioning, the studies reported here are: (i) stored energy in graphite, (ii) graphite radioactivity measurements, (iii) leaching of radionuclide ( 14 C, 36 Cl, 63 Ni, 60 Co, 3 H) from graphite, (iv) chlorine diffusion through graphite. (authors)

Plasminogen activator inhibitor 1 4G/5G and -844G/A variants in idiopathic recurrent pregnancy loss.

Science.gov (United States)

Magdoud, Kalthoum; Herbepin, Viviana G; Touraine, Renaud; Almawi, Wassim Y; Mahjoub, Touhami

2013-09-01

Plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis, and the common promoter region variants -675G/A (4G/5G) and -844G/A are associated with increased thrombotic risk. Despite evidence linking altered fibrinolysis with adverse pregnancy events, including idiopathic recurrent pregnancy loss (RPL), the contribution of PAI-1 variants to RPL risk remains controversial. We investigated the association between the PAI-1 -844G/A and 4G/5G (-675G/A) variants with altered risk of RPL. This was a case-control study involving 304 women with confirmed RPL and 371 age- and ethnically matched control women. PAI-1 genotyping was performed by PCR single-specific primer -675 (G/A) and real-time PCR (-844G/A) analysis. Minor allele frequency (MAF) of 4G/5G (P 5G single-nucleotide polymorphism (SNP) was significantly associated with RPL under additive, dominant, and recessive genetic models; no association of -844G/A with RPL was seen irrespective of the genetic model tested. Taking common -844G/5G haplotype as reference (OR = 1.00), multivariate analysis confirmed the association of 4G-containing -844A/4G (P 5G, but not -844G/A, PAI-1 variant is associated with an increased risk of RPL. © 2013 John Wiley & Sons Ltd.

A novel integrated self-powered brake system for more electric aircraft

Directory of Open Access Journals (Sweden)

Yaoxing SHANG

2018-05-01

Full Text Available Traditional hydraulic brake systems require a complex system of pipelines between an aircraft engine driven pump (EDP and brake actuators, which increases the weight of the aircraft and may even cause serious vibration and leakage problems. In order to improve the reliability and safety of more electric aircraft (MEA, this paper proposes a new integrated self-powered brake system (ISBS for MEA. It uses a hydraulic pump geared to the main wheel to recover a small part of the kinetic energy of a landing aircraft. The recovered energy then serves as the hydraulic power supply for brake actuators. It does not require additional hydraulic source, thus removing the pipelines between an EDP and brake actuators. In addition, its self-powered characteristic makes it possible to brake as usual even in an emergency situation when the airborne power is lost. This paper introduces the working principle of the ISBS and presents a prototype. The mathematical models of a taxiing aircraft and the ISBS are established. A feedback linearization control algorithm is designed to fulfill the anti-skid control. Simulations are carried out to verify the feasibility of the ISBS, and experiments are conducted on a ground inertia brake test bench. The ISBS presents a good performance and provides a new potential solution in the field of brake systems for MEA. Keywords: Hydraulic, Feedback linearization control, More electric aircraft, Novel brake system, Self-powered

76 FR 71081 - Public Aircraft Oversight Safety Forum

Science.gov (United States)

2011-11-16

... NATIONAL TRANSPORTATION SAFETY BOARD Public Aircraft Oversight Safety Forum The National Transportation Safety Board (NTSB) will convene a Public Aircraft Oversight Safety Forum which will begin at 9 a... ``Public Aircraft Oversight Forum: Ensuring Safety for Critical Missions'', are to (1) raise awareness of...

Mission Planning for Unmanned Aircraft with Genetic Algorithms

DEFF Research Database (Denmark)

Hansen, Karl Damkjær

unmanned aircraft are used for aerial surveying of the crops. The farmer takes the role of the analyst above, who does not necessarily have any specific interest in remote controlled aircraft but needs the outcome of the survey. The recurring method in the study is the genetic algorithm; a flexible...... contributions are made in the area of the genetic algorithms. One is a method to decide on the right time to stop the computation of the plan, when the right balance is stricken between using the time planning and using the time flying. The other contribution is a characterization of the evolutionary operators...... used in the genetic algorithm. The result is a measure based on entropy to evaluate and control the diversity of the population of the genetic algorithm, which is an important factor its effectiveness....

Richland Operations Office (DOE-RL) Implementation Plan for DOE Order 435.1

International Nuclear Information System (INIS)

FRITZ, D.W.

2000-01-01

The U.S. Department of Energy issued U.S. Department of Energy Order 435.1, Radioactive Waste Management, and U.S. Department of Energy Manual 435.1-1, Radioactive Waste Management Manual, on July 9, 1999, to replace U.S. Department of Energy Order 5820.2A. Compliance is required by July 9, 2000, where compliance is defined as ''implementing the requirements, or an approved implementation, or corrective action plan'' (refer to Manual, Introduction, paragraph four). This implementation plan identifies the status of each requirement for U.S. Department of Energy, Richland Operations Office Site contractors, and provides the plan, cost, and length of time required for achieving full implementation. The U.S. Department of Energy, Richland Operations Office contractors (Fluor Hanford, Incorporated, DynCorp Tri-Cities Services, Bechtel Hanford, Inc., and Pacific Northwest National Laboratory) conducted a line-by-line review of DOE Order 435.1 and associated manuals to determine which requirements were new, and which requirements already are used for compliance with the previous DOE Order 5820.2A or other requirements. The Gap Analysis for DOE Order 435.1 (HNF-5465) identified compliance gaps, along with other issues that would impact efforts for achieving compliance. The gap analysis also contained a series of assumptions made by the various projects in determining compliance status. The details and section-by-section analysis are contained in Appendix A. Some of the DOE Order 435.1 requirements invoke sections of other DOE Orders not incorporated in various U.S. Department of Energy, Richland Operations Office contracts (refer to Section 2.0, Table 2-1). Those additional DOE Orders are identified by contractor and will be left for evaluation in accordance with each contractor's requirements. No attempt was made to evaluate all of those orders at this time, although in many cases, contractors follow a similar older DOE Order, which is cited in the Appendix. In some areas

The Second Joint NASA/FAA/DOD Conference on Aging Aircraft. Pt. 1

Science.gov (United States)

Harris, Charles E. (Editor)

1999-01-01

The purpose of the Conference was to bring together world leaders in aviation safety research, aircraft design and manufacturing, fleet operation and aviation maintenance to disseminate information on current practices and advanced technologies that will assure the continued airworthiness of the aging aircraft in the military and commercial fleets. The Conference included reviews of current industry practices, assessments of future technology requirements, and status of aviation safety research. The Conference provided an opportunity for interactions among the key personnel in the research and technology development community, the original equipment manufacturers, commercial airline operators, military fleet operators, aviation maintenance, and aircraft certification and regulatory authorities. Conference participation was unrestricted and open to the international aviation community.

Effect of recycle on treatment of aircraft de-icing fluid in an anaerobic ...

African Journals Online (AJOL)

Aircraft de-icing fluid at 7 000 mg COD/ℓ was successfully treated in an anaerobic baffled reactor operated with and without recycle at volumetric organic loading rate of between 4 and 11 g COD/ℓreactor·d. Reactor recycle was found to improve reactor performance. The anaerobic baffled reactor operated with a 6:1 recycle ...

RQ-21A Blackjack Small Tactical Unmanned Aircraft System (STUAS): Initial Operational Test and Evaluation Report

Science.gov (United States)

2015-06-29

Evaluation Report June 2015 This report on the RQ-21A Blackjack Small Tactical Unmanned Aircraft System fulfills the provisions of Title 10...suitability of the RQ-21A Blackjack Small Tactical Unmanned Aircraft System (STUAS) during Initial Operational Test and Evaluation (IOT&E). The Navy’s...66.9 percent). The average service life of the propulsion modules was 48.9 hours, which does not meet the manufacturer’s stated 100-hour

78 FR 25363 - Airworthiness Directives; Diamond Aircraft Industries Airplanes

Science.gov (United States)

2013-05-01

... holidays. For service information identified in this AD, contact Diamond Aircraft Industries GmbH, N.A... Aircraft Industries GmbH has issued Mandatory Service Bulletin 40NG-018/1, dated November 20, 2012. The... Aircraft Industries GmbH Mandatory Service Bulletin 40NG-018/1, dated November 26, 2012. (2) If chafing...

2002 Industry Studies: Aircraft

Science.gov (United States)

2002-01-01

aircraft to a defense electronics, systems integration and information technology company.39 Northrop Grumman no longer seeks a position as a prime...between the military and civil market . Though also upgrading the H-1 helicopter series for the USMC, Bell has mortgaged its future on tiltrotor technology ...business in export dollars, the industry has been forced to look for new markets as worldwide aircraft sales have dropped. Because the U.S. national

Multifuel rotary aircraft engine

Science.gov (United States)

Jones, C.; Berkowitz, M.

1980-01-01

The broad objectives of this paper are the following: (1) to summarize the Curtiss-Wright design, development and field testing background in the area of rotary aircraft engines; (2) to briefly summarize past activity and update development work in the area of stratified charge rotary combustion engines; and (3) to discuss the development of a high-performance direct injected unthrottled stratified charge rotary combustion aircraft engine. Efficiency improvements through turbocharging are also discussed.

The hard X-ray view of the young supernova remnant G1.9+0.3

DEFF Research Database (Denmark)

Zoglauer, Andreas; Reynolds, Stephen P.; An, Hongjun

2015-01-01

NuSTAR observed G1.9+0.3, the youngest known supernova remnant in the Milky Way, for 350 ks and detected emission up to ~30 keV. The remnant's X-ray morphology does not change significantly across the energy range from 3 to 20 keV. A combined fit between NuSTAR and Chandra shows that the spectrum...

Aircraft noise, air pollution, and mortality from myocardial infarction.

Science.gov (United States)

Huss, Anke; Spoerri, Adrian; Egger, Matthias; Röösli, Martin

2010-11-01

Myocardial infarction has been associated with both transportation noise and air pollution. We examined residential exposure to aircraft noise and mortality from myocardial infarction, taking air pollution into account. We analyzed the Swiss National Cohort, which includes geocoded information on residence. Exposure to aircraft noise and air pollution was determined based on geospatial noise and air-pollution (PM10) models and distance to major roads. We used Cox proportional hazard models, with age as the timescale. We compared the risk of death across categories of A-weighted sound pressure levels (dB(A)) and by duration of living in exposed corridors, adjusting for PM10 levels, distance to major roads, sex, education, and socioeconomic position of the municipality. We analyzed 4.6 million persons older than 30 years who were followed from near the end of 2000 through December 2005, including 15,532 deaths from myocardial infarction (ICD-10 codes I 21, I 22). Mortality increased with increasing level and duration of aircraft noise. The adjusted hazard ratio comparing ≥60 dB(A) with noise. Aircraft noise was associated with mortality from myocardial infarction, with a dose-response relationship for level and duration of exposure. The association does not appear to be explained by exposure to particulate matter air pollution, education, or socioeconomic status of the municipality.

The prevalence of PAI-1 4G/5G gene variant in Serbian population

Directory of Open Access Journals (Sweden)

Đorđević Valentina

2013-01-01

Full Text Available Introduction: Plasminogen activator inhibitor 1 (PAI-1 has a major role in inhibition of firinolysis and normal haemostasis. The presence of the PAI-1 4G/4G genotype leads to increased expression of PAI-1. High blood level of PAI-1 is associated with many diseases such as thrombosis, cerebral insult, myocardial infarction, pregnancy loss, preeclampsia, insulin resistance, type 2 diabetes, breast cancer and asthma. In this study, the prevalence of PAI-1 4G/5G gene variant was determined in healthy subjects from Serbian population. Methods: The study was carried out in a group of 210 healthy subjects (105 women and 105 men. The presence of PAI-1 4G/5G gene variant was detected by PCR-RFLP analysis. Results: The prevalence of PAI-1 4G/4G genotype was 34.76% and it was increased compared to PAI-1 5G/5G genotype (19.05%. The most frequent was PAI-1 4G/5G genotype (46.19%. Allelic frequency for 4G allele was higher (0.58 compared to 5G allele (0.42. Conclusions: The prevalence of PAI-1 4G/5G gene variant in Serbian population is similar to the neighboring populations. Results of this study represent the first data for Serbian population. This study could be useful for further research where the role of PAI-1 4G/5G gene variant will be assessed in the pathogenesis of many diseases.

Propulsion controlled aircraft computer

Science.gov (United States)

Cogan, Bruce R. (Inventor)

2010-01-01

A low-cost, easily retrofit Propulsion Controlled Aircraft (PCA) system for use on a wide range of commercial and military aircraft consists of an propulsion controlled aircraft computer that reads in aircraft data including aircraft state, pilot commands and other related data, calculates aircraft throttle position for a given maneuver commanded by the pilot, and then displays both current and calculated throttle position on a cockpit display to show the pilot where to move throttles to achieve the commanded maneuver, or is automatically sent digitally to command the engines directly.

The H,G_1,G_2 photometric system with scarce observational data

Science.gov (United States)

Penttilä, A.; Granvik, M.; Muinonen, K.; Wilkman, O.

2014-07-01

The H,G_1,G_2 photometric system was officially adopted at the IAU General Assembly in Beijing, 2012. The system replaced the H,G system from 1985. The 'photometric system' is a parametrized model V(α; params) for the magnitude-phase relation of small Solar System bodies, and the main purpose is to predict the magnitude at backscattering, H := V(0°), i.e., the (absolute) magnitude of the object. The original H,G system was designed using the best available data in 1985, but since then new observations have been made showing certain features, especially near backscattering, to which the H,G function has troubles adjusting to. The H,G_1,G_2 system was developed especially to address these issues [1]. With a sufficient number of high-accuracy observations and with a wide phase-angle coverage, the H,G_1,G_2 system performs well. However, with scarce low-accuracy data the system has troubles producing a reliable fit, as would any other three-parameter nonlinear function. Therefore, simultaneously with the H,G_1,G_2 system, a two-parameter version of the model, the H,G_{12} system, was introduced [1]. The two-parameter version ties the parameters G_1,G_2 into a single parameter G_{12} by a linear relation, and still uses the H,G_1,G_2 system in the background. This version dramatically improves the possibility to receive a reliable phase-curve fit to scarce data. The amount of observed small bodies is increasing all the time, and so is the need to produce estimates for the absolute magnitude/diameter/albedo and other size/composition related parameters. The lack of small-phase-angle observations is especially topical for near-Earth objects (NEOs). With these, even the two- parameter version faces problems. The previous procedure with the H,G system in such circumstances has been that the G-parameter has been fixed to some constant value, thus only fitting a single-parameter function. In conclusion, there is a definitive need for a reliable procedure to produce

Incidência de fumonisina B1, aflatoxinas B1, B2, G1 e G2, ocratoxina A e zearalenona em produtos de milho Occurrence of fumonisin B1, aflatoxins B1, B2, G1, and G2, ochratoxin A and zearalenone in corn products

Directory of Open Access Journals (Sweden)

Luciane Mie Kawashima

2006-09-01

Full Text Available Levantamentos de ocorrência de micotoxinas em alimentos foram realizados nas últimas duas décadas nas regiões Sudeste e Sul do Brasil. Levantamentos em alimentos comercializados em outras regiões têm-se limitado a aflatoxinas em amendoim e castanhas do Brasil. O presente trabalho pesquisou a presença de fumonisina B1, aflatoxinas B1, B2, G1 e G2, ocratoxina A e zearalenona em 74 amostras de produtos a base de milho adquiridas no comércio da cidade de Recife, PE, durante o período de 1999 a 2001. Fumonisina B1 foi determinada por cromatografia líquida de alta eficiência com detecção por fluorescência e as demais toxinas foram determinadas por cromatografia em camada delgada. Fumonisina B1 foi encontrada em 94,6% das amostras em concentrações variando de 20 a 8600 µg/kg. Apenas 5 amostras continham aflatoxina B1 e o teor máximo encontrado foi 20 µg/kg. Duas amostras ultrapassaram o limite de 20 µg/kg para a somatória das aflatoxinas B1, B2, G1 e G2 (farinha de milho pré-cozida com 21,5 µg/kg e quirera (xerém com 23,3 µg/kg. As aflatoxinas G1 e G2, ocratoxina A e zearalenona não foram detectadas em nenhuma das amostras. Todas as amostras contaminadas com aflatoxinas também apresentaram fumonisina B1.Research concerning the presence of mycotoxin in food has been conducted in the Southwest and South regions of Brazil over the last two decades. Research in other regions has been limited to aflatoxin in peanuts and Brazil nuts. The aim of this work is to study the presence of fumonisin B1, aflatoxins B1, B2, G1, and G2, ochratoxin A and zearalenone in 74 samples of corn products acquired in shops and food markets in the city of Recife (PE from 1999 to 2001. Fumonisin B1 was determined by high performance liquid chromatography and fluorescence was detected. The other toxins were determined by thin layer chromatography. Fumonisin B1 was found in 94.6% of the samples in levels from 20 to 8600 µg/kg. Only 5 samples contained

78 FR 60656 - Airworthiness Directives; Sikorsky Aircraft Corporation Helicopters

Science.gov (United States)

2013-10-02

... Airworthiness Directives; Sikorsky Aircraft Corporation Helicopters AGENCY: Federal Aviation Administration (FAA... Aircraft Corporation (Sikorsky) Model S-92A helicopters to require modifying the No. 1 engine forward... Sikorsky Aircraft Corporation, Attn: Manager, Commercial Technical Support, mailstop s581a, 6900 Main...

AutoGNI, the Robot Under the Aircraft Floor: An Automated System for Sampling Giant Aerosol Particles by Impaction in the Free Airstream Outside a Research Aircraft

Science.gov (United States)

Jensen, J. B.; Schwenz, K.; Aquino, J.; Carnes, J.; Webster, C.; Munnerlyn, J.; Wissman, T.; Lugger, T.

2017-12-01

Giant sea-salt aerosol particles, also called Giant Cloud Condensation Nuclei (GCCN), have been proposed as a means of rapidly forming precipitation sized drizzle drops in warm marine clouds (e.g., Jensen and Nugent, 2017). Such rare particles are best sampled from aircraft in air below cloud base, where normal laser optical instruments have too low sample volume to give statistically significant samples of the large particle tail. An automated sampling system (the AutoGNI) has been built to operate from inside a pressurized aircraft. Under the aircraft floor, a pressurized vessel contains 32 custom-built polycarbonate microscope slides. Using robotics with 5 motor drives and 18 positioning switches, the AutoGNI can take slides from their holding cassettes, pass them onto a caddy in an airfoil that extends 200 mm outside the aircraft, where they are exposed in the free airstream, thus avoiding the usual problems with large particle losses in air intakes. Slides are typically exposed for 10-30 s in the marine boundary layer, giving sample volumes of about 100-300 L or more. Subsequently the slides are retracted into the pressure vessel, stored and transported for laboratory microscope image analysis, in order to derive size-distribution histograms. While the aircraft is flying, the AutoGNI system is remotely controlled from a laptop on the ground, using an encrypted commercial satellite connection to the NSF/NCAR GV research aircraft's main server, and onto the AutoGNI microprocessor. The sampling of such GCCN is becoming increasingly important in order to provide complete input data for model calculations of aerosol-cloud interactions and their feedbacks in climate prediction. The AutoGNI has so far been sampling sea-salt GCCN in the Magellan Straight during the 2016 ORCAS project and over the NW Pacific during the 2017 ARISTO project, both from the NSF/NCAR GV research aircraft. Sea-salt particle sizes of 1.4 - 32 μm dry diameter have been observed.

PAI-1 4G/5G polymorphism contributes to cancer susceptibility: evidence from meta-analysis.

Science.gov (United States)

Wang, Shangqian; Cao, Qiang; Wang, Xiaoxiang; Li, Bingjie; Tang, Min; Yuan, Wanqing; Fang, Jianzheng; Qian, Jian; Qin, Chao; Zhang, Wei

2013-01-01

The plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and allows the modulation of cancer growth, invasion and angiogenesis. To date, studies investigated the association between a functional polymorphism in PAI-1 (4G/5G) and risk of cancer have shown inclusive results. A meta-analysis based on 25 case-control studies was performed to address this issue. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical heterogeneity across studies was examined with I(2) test. Overall, a significant increased risk of cancer was associated with the PAI-1 4G/4G polymorphism for the allele contrast (4G vs. 5G: OR = 1.10, CI = 1.03-1.18, I(2) = 49.5%), the additive genetic model (4G/4G vs. 5G/5G: OR = 1.21, CI = 1.06-1.39, I(2) = 51.9%), the recessive genetic model (4G/4G vs. 4G/5G+5G/5G: OR = 1.11, CI = 1.04-1.18, I(2) = 20.8%). In the subgroup analysis by ethnicity, the results indicated that individuals with 4G/4G genotype had a significantly higher cancer risk among Caucasians (4G/4G vs. 5G/5G: OR = 1.31, 95%CI = 1.09-1.59, I(2) = 59.6%; 4G/4G vs. 4G/5G: OR = 1.12, 95%CI = 1.04-1.21, I(2) = 3.6%; recessive model: OR = 1.12, 95%CI = 1.05-1.21, I(2) = 25.3%). The results of the present meta-analysis support an association between the PAI-1 4G/5G polymorphism and increasing cancer risk, especially among Caucasians, and those with 4G allele have a high risk to develop colorectal cancer and endometrial cancer.

Identifying Human Factors Issues in Aircraft Maintenance Operations

Science.gov (United States)

Veinott, Elizabeth S.; Kanki, Barbara G.; Shafto, Michael G. (Technical Monitor)

1995-01-01

Maintenance operations incidents submitted to the Aviation Safety Reporting System (ASRS) between 1986-1992 were systematically analyzed in order to identify issues relevant to human factors and crew coordination. This exploratory analysis involved 95 ASRS reports which represented a wide range of maintenance incidents. The reports were coded and analyzed according to the type of error (e.g, wrong part, procedural error, non-procedural error), contributing factors (e.g., individual, within-team, cross-team, procedure, tools), result of the error (e.g., aircraft damage or not) as well as the operational impact (e.g., aircraft flown to destination, air return, delay at gate). The main findings indicate that procedural errors were most common (48.4%) and that individual and team actions contributed to the errors in more than 50% of the cases. As for operational results, most errors were either corrected after landing at the destination (51.6%) or required the flight crew to stop enroute (29.5%). Interactions among these variables are also discussed. This analysis is a first step toward developing a taxonomy of crew coordination problems in maintenance. By understanding what variables are important and how they are interrelated, we may develop intervention strategies that are better tailored to the human factor issues involved.

Pulling G Human Responses to High and Low Gravity

CERN Document Server

Seedhouse, Erik

2013-01-01

Formula 1 racing drivers, figher pilots, astronauts - G forces are an integral part of their lives - How do racing drivers sustain high G loads and not pass out? - What accelerative forces are unleashed when a fighter pilot ejects from a high-performance jet? - What is it like being launched into space and what are the effects on astronauts living in zero G on board the International Space Station? - How do aircraft simulate zero G? Pulling G gives a unique insight into how G forces affect people working inthe high and low G environments. It examines the risks of high and low acceleration and explains the physiology of surviving in these environments. The history of G-related research is described, together with present-day and future development of methods to cope with the effects of increased and reduced G.

26 CFR 1.883-1T - Exclusion of income from the international operation of ships or aircraft (temporary).

Science.gov (United States)

2010-04-01

... domestic law tax exemption for income derived from the international operation of ships or aircraft, either... from tax for profits from the operation of ships or aircraft in international transport or international traffic under the shipping and air transport or gains article of an income tax convention with the...

Advanced aircraft service life monitoring method via flight-by-flight load spectra

Science.gov (United States)

Lee, Hongchul

This research is an effort to understand current method and to propose an advanced method for Damage Tolerance Analysis (DTA) for the purpose of monitoring the aircraft service life. As one of tasks in the DTA, the current indirect Individual Aircraft Tracking (IAT) method for the F-16C/D Block 32 does not properly represent changes in flight usage severity affecting structural fatigue life. Therefore, an advanced aircraft service life monitoring method based on flight-by-flight load spectra is proposed and recommended for IAT program to track consumed fatigue life as an alternative to the current method which is based on the crack severity index (CSI) value. Damage Tolerance is one of aircraft design philosophies to ensure that aging aircrafts satisfy structural reliability in terms of fatigue failures throughout their service periods. IAT program, one of the most important tasks of DTA, is able to track potential structural crack growth at critical areas in the major airframe structural components of individual aircraft. The F-16C/D aircraft is equipped with a flight data recorder to monitor flight usage and provide the data to support structural load analysis. However, limited memory of flight data recorder allows user to monitor individual aircraft fatigue usage in terms of only the vertical inertia (NzW) data for calculating Crack Severity Index (CSI) value which defines the relative maneuver severity. Current IAT method for the F-16C/D Block 32 based on CSI value calculated from NzW is shown to be not accurate enough to monitor individual aircraft fatigue usage due to several problems. The proposed advanced aircraft service life monitoring method based on flight-by-flight load spectra is recommended as an improved method for the F-16C/D Block 32 aircraft. Flight-by-flight load spectra was generated from downloaded Crash Survival Flight Data Recorder (CSFDR) data by calculating loads for each time hack in selected flight data utilizing loads equations. From

[PAL-1 5G/4G polymorphism in patients with systemic lupus erythematosus].

Science.gov (United States)

Savov, A; Andonova, S; Tanev, D; Robeva, R; Marincheva, Ts; Tomova, A; Kumanov, Ph; Rashkov, R; Kolarov, Zl

2014-01-01

Systemic lupus erythematosus (SLE) is a connective tissue disease affecting predominantly women that has been widely associated with obstetric complications. Inherited thrombophilias are significant risk factors for pregnancy loss, but their role in patients with SLE, and especially in those without concomitant secondary antiphospholipid syndrome (APS) has not been clarified. The aim of the present study was to study PAI-1 5G/4G polymorphism in women with lupus. A total of 103 SLE patients as well as 69 healthy volunteers were genotyped for PAI-1 5G/4G (rs1799889). No significant differences in the PAI-1 5G/4G genotype prevalence between patients and controls were found. After exclusion of the women with secondary APS, the frequency of pregnancies and spontaneous abortions, as well as the number of live births were similar in the studied patients with different PAI-1 genotype (p> 0.05). PAI-1 5G/4G polymorphism was not significantly related to any of the lupus ACR criteria or disease activity (p > 0.05), but it could influence the platelet number in the studied patients (263.52 ± 91.10 [5G/5G genotype] versus 210.12 ± 71.79 [4G/4G genotype], p = 0.023). In conclusion, our results showed that PAI-1 4G/5G polymorphism did not worsen the reproductive outcome in SLE women without secondary APS.

Small transport aircraft technology

Science.gov (United States)

Williams, L. J.

1983-01-01

Information on commuter airline trends and aircraft developments is provided to upgrade the preliminary findings of a NASA-formed small transport aircraft technology (STAT) team, established to determine whether the agency's research and development programs could help commuter aircraft manufacturers solve technical problems related to passenger acceptance and use of 19- to 50-passenger aircraft. The results and conclusions of the full set of completed STAT studies are presented. These studies were performed by five airplane manufacturers, five engine manufacturers, and two propeller manufacturers. Those portions of NASA's overall aeronautics research and development programs which are applicable to commuter aircraft design are summarized. Areas of technology that might beneficially be expanded or initiated to aid the US commuter aircraft manufacturers in the evolution of improved aircraft for the market are suggested.

PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells

International Nuclear Information System (INIS)

Mogilenko, Denis A.; Shavva, Vladimir S.; Dizhe, Ella B.; Orlov, Sergey V.; Perevozchikov, Andrej P.

2010-01-01

Research highlights: → PPARγ activates ABCA1 gene expression but decreases ABCA1 protein content in human hepatoma cell line HepG2. → Treatment of HepG2 cells with PPARγ agonist GW1929 leads to dissociation of LXRβ from ABCA1-LXRβ complex. → Inhibition of protein kinases MEK1/2 abolishes PPARγ-mediated dissociation of LXRβ from ABCA1/LXRβ complex. → Activation of PPARγ leads to increasing of the level of LXRβ associated with LXRE within ABCA1 gene promoter. -- Abstract: Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals. Nuclear receptor PPARγ is known as activator of ABCA1 expression, but details of PPARγ-mediated regulation of ABCA1 at both transcriptional and post-transcriptional levels in hepatocytes have not still been well elucidated. In this study we have shown, that PPARγ activates ABCA1 gene transcription in human hepatoma cells HepG2 through increasing of LXRβ binding with promoter region of ABCA1 gene. Treatment of HepG2 cells with PPARγ agonist GW1929 leads to dissociation of LXRβ from ABCA1/LXRβ complex and to nuclear translocation of this nuclear receptor resulting in reduction of ABCA1 protein level 24 h after treatment. Inhibition of protein kinases MEK1/2 abolishes PPARγ-mediated dissociation of LXRβ from ABCA1/LXRβ complex, but does not block PPARγ-dependent down-regulation of ABCA1 protein in HepG2 cells. These data suggest that PPARγ may be important for regulation of the level of hepatic ABCA1 protein and indicate the new interplays between PPARγ, LXRβ and MEK1/2 in regulation of ABCA1 mRNA and protein expression.

PAI-1 mRNA expression and plasma level in rheumatoid arthritis: relationship with 4G/5G PAI-1 polymorphism.

Science.gov (United States)

Muñoz-Valle, José Francisco; Ruiz-Quezada, Sandra Luz; Oregón-Romero, Edith; Navarro-Hernández, Rosa Elena; Castañeda-Saucedo, Eduardo; De la Cruz-Mosso, Ulises; Illades-Aguiar, Berenice; Leyva-Vázquez, Marco Antonio; Castro-Alarcón, Natividad; Parra-Rojas, Isela

2012-12-01

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial membrane, cartilage and bone. PAI-1 is a key regulator of the fibrinolytic system through which plasminogen is converted to plasmin. The plasmin activates the matrix metalloproteinase system, which is closely related with the joint damage and bone destruction in RA. The aim of this study was to investigate the relationship between 4G/5G PAI-1 polymorphism with mRNA expression and PAI-1 plasma protein levels in RA patients. 113 RA patients and 123 healthy subjects (HS) were included in the study. The 4G/5G PAI-1 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism method; the PAI-1 mRNA expression was determined by real-time PCR; and the soluble PAI-1 (sPAI-1) levels were quantified using an ELISA kit. No significant differences in the genotype and allele frequencies of 4G/5G PAI-1 polymorphism were found between RA patients and HS. However, the 5G/5G genotype was the most frequent in both studied groups: RA (42%) and HS (44%). PAI-1 mRNA expression was slightly increased (0.67 fold) in RA patients with respect to HS (P = 0.0001). In addition, in RA patients, the 4G/4G genotype carriers showed increased PAI-1 mRNA expression (3.82 fold) versus 4G/5G and 5G/5G genotypes (P = 0.0001), whereas the sPAI-1 plasma levels did not show significant differences. Our results indicate that the 4G/5G PAI-1 polymorphism is not a marker of susceptibility in the Western Mexico. However, the 4G/4G genotype is associated with high PAI-1 mRNA expression but not with the sPAI-1 levels in RA patients.

DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda

Science.gov (United States)

Vítová, Milada; Bišová, Kateřina; Zachleder, Vilém

2011-01-01

DNA damage is a threat to genomic integrity in all living organisms. Plants and green algae are particularly susceptible to DNA damage especially that caused by UV light, due to their light dependency for photosynthesis. For survival of a plant, and other eukaryotic cells, it is essential for an organism to continuously check the integrity of its genetic material and, when damaged, to repair it immediately. Cells therefore utilize a DNA damage response pathway that is responsible for sensing, reacting to and repairing damaged DNA. We have studied the effect of 5-fluorodeoxyuridine, zeocin, caffeine and combinations of these on the cell cycle of the green alga Scenedesmus quadricauda. The cells delayed S phase and underwent a permanent G2 phase block if DNA metabolism was affected prior to S phase; the G2 phase block imposed by zeocin was partially abolished by caffeine. No cell cycle block was observed if the treatment with zeocin occurred in G2 phase and the cells divided normally. CDKA and CDKB kinases regulate mitosis in S. quadricauda; their kinase activities were inhibited by Wee1. CDKA, CDKB protein levels were stabilized in the presence of zeocin. In contrast, the protein level of Wee1 was unaffected by DNA perturbing treatments. Wee1 therefore does not appear to be involved in the DNA damage response in S. quadricauda. Our results imply a specific reaction to DNA damage in S. quadricauda, with no cell cycle arrest, after experiencing DNA damage during G2 phase. PMID:21603605

DNA damage during G2 phase does not affect cell cycle progression of the green alga Scenedesmus quadricauda.

Directory of Open Access Journals (Sweden)

Monika Hlavová

Full Text Available DNA damage is a threat to genomic integrity in all living organisms. Plants and green algae are particularly susceptible to DNA damage especially that caused by UV light, due to their light dependency for photosynthesis. For survival of a plant, and other eukaryotic cells, it is essential for an organism to continuously check the integrity of its genetic material and, when damaged, to repair it immediately. Cells therefore utilize a DNA damage response pathway that is responsible for sensing, reacting to and repairing damaged DNA. We have studied the effect of 5-fluorodeoxyuridine, zeocin, caffeine and combinations of these on the cell cycle of the green alga Scenedesmus quadricauda. The cells delayed S phase and underwent a permanent G2 phase block if DNA metabolism was affected prior to S phase; the G2 phase block imposed by zeocin was partially abolished by caffeine. No cell cycle block was observed if the treatment with zeocin occurred in G2 phase and the cells divided normally. CDKA and CDKB kinases regulate mitosis in S. quadricauda; their kinase activities were inhibited by Wee1. CDKA, CDKB protein levels were stabilized in the presence of zeocin. In contrast, the protein level of Wee1 was unaffected by DNA perturbing treatments. Wee1 therefore does not appear to be involved in the DNA damage response in S. quadricauda. Our results imply a specific reaction to DNA damage in S. quadricauda, with no cell cycle arrest, after experiencing DNA damage during G2 phase.

Implementation guide for use with suspect/counterfeit items: Requirements of DOE O 440.1, worker protection management; 10 CFR 830.120; and DOE 5700.6C, quality assurance

International Nuclear Information System (INIS)

1997-06-01

Department of Energy (DOE) Order (O) 440.1, Worker Protection Management For DOE Federal and Contractors Employees, [7] sets forth requirements for DOE and its contractors to implement suspect and counterfeit items (S/CI) controls as part of the quality assurance (QA) programs required by 10 Code of Federal Regulations (CFR) 830.120 [8] or DOE 5700.6C, Quality Assurance [9]. DOE G-830.120, Implementation Guide for Use with 10 CFR Part 830.120, Quality Assurance, [10] provides additional guidance on establishing and implementing effective QA processes to control S/CIs. DOE O 232.1, Occurrence Reporting and Processing of Operations, [11] specifies requirements for reporting S/CIs under the DOE Occurrence Reporting and Processing System (ORPS). DOE promulgated the requirements and guidance to control or eliminate the hazards posed by S/CIs, which can lead to unexpected equipment failures and undue risks to the DOE mission, the environment, and personnel. This Guide is a compendium of information contained in the referenced DOE directives and other documents concerning S/CI controls. It incorporates, updates, and supersedes earlier guidance issued in Plan for the Suspect/Counterfeit Products Issue in the Department of Energy, dated October 1993, [4] and in memoranda issued by Defense Programs (DP) [12-16] and other DOE program offices. This guidance was developed to strengthen the procurement process, identify and eliminate S/CIs, and improve the reporting of S/CIs. The information in this Guide, when implemented by DOE and its contractors, will satisfy the S/CI requirements contained in the referenced DOE directives

Implementation guide for use with suspect/counterfeit items: Requirements of DOE O 440.1, worker protection management; 10 CFR 830.120; and DOE 5700.6C, quality assurance

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-06-01

Department of Energy (DOE) Order (O) 440.1, Worker Protection Management For DOE Federal and Contractors Employees, [7] sets forth requirements for DOE and its contractors to implement suspect and counterfeit items (S/CI) controls as part of the quality assurance (QA) programs required by 10 Code of Federal Regulations (CFR) 830.120 [8] or DOE 5700.6C, Quality Assurance [9]. DOE G-830.120, Implementation Guide for Use with 10 CFR Part 830.120, Quality Assurance, [10] provides additional guidance on establishing and implementing effective QA processes to control S/CIs. DOE O 232.1, Occurrence Reporting and Processing of Operations, [11] specifies requirements for reporting S/CIs under the DOE Occurrence Reporting and Processing System (ORPS). DOE promulgated the requirements and guidance to control or eliminate the hazards posed by S/CIs, which can lead to unexpected equipment failures and undue risks to the DOE mission, the environment, and personnel. This Guide is a compendium of information contained in the referenced DOE directives and other documents concerning S/CI controls. It incorporates, updates, and supersedes earlier guidance issued in Plan for the Suspect/Counterfeit Products Issue in the Department of Energy, dated October 1993, [4] and in memoranda issued by Defense Programs (DP) [12-16] and other DOE program offices. This guidance was developed to strengthen the procurement process, identify and eliminate S/CIs, and improve the reporting of S/CIs. The information in this Guide, when implemented by DOE and its contractors, will satisfy the S/CI requirements contained in the referenced DOE directives.

The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts

DEFF Research Database (Denmark)

Aplin, Mark; Christensen, Gitte Lund; Schneider, Mikael

2007-01-01

The angiotensin II (AngII) type 1 receptor (AT(1)R) has been shown to activate extracellular signal-regulated kinases 1 and 2 (ERK1/2) through G proteins or G protein-independently through beta-arrestin2 in cellular expression systems. As activation mechanisms may greatly influence the biological...... effects of ERK1/2 activity, differential activation of the AT(1)R in its native cellular context could have important biological and pharmacological implications. To examine if AT(1)R activates ERK1/2 by G protein-independent mechanisms in the heart, we used the [Sar(1), Ile(4), Ile(8)]-AngII ([SII] Ang......II) analogue in native preparations of cardiac myocytes and beating hearts. We found that [SII] AngII does not activate G(q)-coupling, yet stimulates the beta-arrestin2-dependent ERK1/2. The G(q)-activated pool of ERK1/2 rapidly translocates to the nucleus, while the beta-arrestin2-scaffolded pool remains...

Physical characterization of the fine particle emissions from commercial aircraft engines during the Aircraft Particle Emissions eXperiment (APEX) 1-3

Science.gov (United States)

Kinsey, John S.; Dong, Yuanji; Williams, D. Craig; Logan, Russell

2010-06-01

The fine particulate matter (PM) emissions from nine commercial aircraft engine models were determined by plume sampling during the three field campaigns of the Aircraft Particle Emissions Experiment (APEX). Ground-based measurements were made primarily at 30 m behind the engine for PM mass and number concentration, particle size distribution, and total volatile matter using both time-integrated and continuous sampling techniques. The experimental results showed a PM mass emission index (EI) ranging from 10 to 550 mg kg -1 fuel depending on engine type and test parameters as well as a characteristic U-shaped curve of the mass EI with increasing fuel flow for the turbofan engines tested. Also, the Teflon filter sampling indicated that ˜40-80% of the total PM mass on a test-average basis was comprised of volatile matter (sulfur and organics) for most engines sampled. The number EIs, on the other hand, varied from ˜10 15 to 10 17 particles kg -1 fuel with the turbofan engines exhibiting a logarithmic decay with increasing fuel flow. Finally, the particle size distributions of the emissions exhibited a single primary mode that were lognormally distributed with a minor accumulation mode also observed at higher powers for all engines tested. The geometric (number) mean particle diameter ranged from 9.4 to 37 nm and the geometric standard deviation ranged from 1.3 to 2.3 depending on engine type, fuel flow, and test conditions.

The pressure of hot QCD up to $g^{6}$ ln(1/g)

CERN Document Server

Kajantie, Keijou; Rummukainen, K; Schröder, Y

2003-01-01

The free energy density, or pressure, of QCD has at high temperatures an expansion in the coupling constant g, known so far up to order g^5. We compute here the last contribution which can be determined perturbatively, g^6 ln(1/g), by summing together results for the 4-loop vacuum energy densities of two different three-dimensional effective field theories. We also demonstrate that the inclusion of the new perturbative g^6 ln(1/g) terms, together with the so far unknown perturbative and non-perturbative g^6 terms, could potentially extend the applicability of the resummed coupling constant series down to surprisingly low temperatures.

77 FR 72250 - Airworthiness Directives; Cessna Aircraft Company Airplanes

Science.gov (United States)

2012-12-05

... Joint Aircraft System Component (JASC)/Air Transport Association (ATA) of America Code 2820, Aircraft Fuel Distribution System. (e) Unsafe Condition This AD was prompted by reports of chafing of a new... flight, reinstall the fuel return line assembly (Cessna P/N 0516031-1) following Cessna Aircraft Company...

26 CFR 1.514(g)-1 - Business lease indebtedness.

Science.gov (United States)

2010-04-01

....514(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxation of Business Income of Certain Exempt Organizations § 1.514(g)-1... to cases such as the following: Example 1. A university pledges some of its investment securities...

Aircraft gas turbines

Energy Technology Data Exchange (ETDEWEB)

Sekido, T [Ishikawajima-Harima Heavy Industries, Co. Ltd., Tokyo (Japan)

1994-03-01

Current developmental activities of aircraft gas turbines in Japan are reviewed. V2500-A5 engine with thrust of 30,000 LBF is scheduled to be used for real aircraft in 1994, and intensive developmental activities are also proceeding in larger engines over 90,000 LBF. Recently, developmental programs of engines for 75-100 seat aircraft have been actively discussed, and Japanese engine makers are having discussions towards international collaboration. Such engines will be high bypass turbofans of 12,000-22,000 LBF. Development of SST/HST engines in a speed range from subsonic to Mach 5 is under the initiative of the Agency of Industrial Science and Technology. The Technical Research and Development Institute of Japan, Defence Agency achieved the target thrust of 3.4 tons in the small turbofan engine program, and the small turboshaft engine for small helicopters is also under development. Both National Aerospace Laboratory (NAL) and Institute of Space and Aeronautical Science (ISAS) are now conducting the research programs on turbo-ramjet engines under a component test phase. 1 fig.

Do supersonic aircraft avoid contrails?

Directory of Open Access Journals (Sweden)

A. Stenke

2008-02-01

Full Text Available The impact of a potential future fleet of supersonic aircraft on contrail coverage and contrail radiative forcing is investigated by means of simulations with the general circulation model ECHAM4.L39(DLR including a contrail parameterization. The model simulations consider air traffic inventories of a subsonic fleet and of a combined fleet of sub- and supersonic aircraft for the years 2025 and 2050, respectively. In case of the combined fleet, part of the subsonic fleet is replaced by supersonic aircraft. The combined air traffic scenario reveals a reduction in contrail cover at subsonic cruise levels (10 to 12 km in the northern extratropics, especially over the North Atlantic and North Pacific. At supersonic flight levels (18 to 20 km, contrail formation is mainly restricted to tropical regions. Only in winter is the northern extratropical stratosphere above the 100 hPa level cold enough for the formation of contrails. Total contrail coverage is only marginally affected by the shift in flight altitude. The model simulations indicate a global annual mean contrail cover of 0.372% for the subsonic and 0.366% for the combined fleet in 2050. The simulated contrail radiative forcing is most closely correlated to the total contrail cover, although contrails in the tropical lower stratosphere are found to be optically thinner than contrails in the extratropical upper troposphere. The global annual mean contrail radiative forcing in 2050 (2025 amounts to 24.7 mW m⁻² (9.4 mW m⁻² for the subsonic fleet and 24.2 mW m⁻² (9.3 mW m⁻² for the combined fleet. A reduction of the supersonic cruise speed from Mach 2.0 to Mach 1.6 leads to a downward shift in contrail cover, but does not affect global mean total contrail cover and contrail radiative forcing. Hence the partial substitution of subsonic air traffic leads to a shift of contrail occurrence from mid to low latitudes, but the resulting change in

Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 1

Science.gov (United States)

Bigelow, Catherine A. (Compiler)

1997-01-01

This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

Predicting visibility of aircraft.

Directory of Open Access Journals (Sweden)

Andrew Watson

Full Text Available Visual detection of aircraft by human observers is an important element of aviation safety. To assess and ensure safety, it would be useful to be able to be able to predict the visibility, to a human observer, of an aircraft of specified size, shape, distance, and coloration. Examples include assuring safe separation among aircraft and between aircraft and unmanned vehicles, design of airport control towers, and efforts to enhance or suppress the visibility of military and rescue vehicles. We have recently developed a simple metric of pattern visibility, the Spatial Standard Observer (SSO. In this report we examine whether the SSO can predict visibility of simulated aircraft images. We constructed a set of aircraft images from three-dimensional computer graphic models, and measured the luminance contrast threshold for each image from three human observers. The data were well predicted by the SSO. Finally, we show how to use the SSO to predict visibility range for aircraft of arbitrary size, shape, distance, and coloration.

Wind data collected by a fixed-wing aircraft in the vicinity of a tropical cyclone over the south China coastal waters

Energy Technology Data Exchange (ETDEWEB)

Chan, P.W.; Hon, K.K. [Hong Kong Observatory, Kowloon, HK (China); Foster, S. [Aventech Research Inc., Ontario (Canada)

2011-06-15

The fixed-wing aircraft of Government Flying Service of the Hong Kong Government has recently equipped with an upgraded meteorological measuring system. This system provides horizontal wind velocity components up to 90 m/s at an accuracy of 0.5 m/s for straight and level flight. Besides search and rescue (SAR) missions, this aircraft is also used for windshear and turbulence investigation flights at the Hong Kong International Airport. In a SAR operation in July 2009, the aircraft flew close to the eye of tropical cyclone Molave, when it was located at about 200 km to the east of Hong Kong over the south China coastal waters. The aircraft provided valuable information about the winds in association with Molave because aircraft reconnaissance for tropical cyclones is not carried out for South China Sea. Based on the aircraft measurements, the 1-second mean wind reached the maximum value of 88 knots at a height of 200 m above mean sea level. Assuming a power law with altitude with an exponent of 0.11 over open waters, the corresponding 1-second mean wind at a height of 10 m would be about 63 knots. The maximum 10-minute mean wind reached 69 knots with an average height of 260 m above mean sea level. The corresponding mean at 10 m would be about 48 knots. As such, based on the aircraft measurements (in which the aircraft might not fly into the areas of maximum winds associated with the tropical cyclone), Molave had at least a strength of tropical storm to severe tropical storm at the times of the measurements. Nowadays, the determination of the intensity of tropical cyclones over the South China Sea is normally based on remote sensing data only (e.g. radar and satellite observations). To the knowledge of the authors, the results presented in the paper are the first time that direct measurements of the winds near the centre of a tropical cyclone over the northern part of the South China Sea are made with an aircraft. Apart from the mean wind and gust, other properties

EA 18G Growler Aircraft (EA 18G)

Science.gov (United States)

2015-12-01

10051.9 N/A 13186.9 8636.4 11550.1 15672.4 1 APB Breach Confidence Level Confidence Level of cost estimate for current APB: 50% The current...estimate recommendation aims to provide sufficient resources to execute the program under normal conditions, encountering average levels of technical...TY $M) Initial PAUC Development Estimate Changes PAUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 93.573 4.150 1.442 -0.319 0.947 -0.348

Los Alamos National Laboratory DOE M441.1-1 implementation

International Nuclear Information System (INIS)

Worl, Laura A.; Veirs, D. Kirk; Smith, Paul H.; Yarbro, Tresa F.; Stone, Timothy A.

2010-01-01

Loss of containment of nuclear material stored in containers such as food-pack cans, paint cans, or taped slip lid cans has generated concern about packaging requirements for interim storage of nuclear materials in working facilities such as the plutonium facility at Los Alamos National Laboratory (LANL). The Department of Energy (DOE) issued DOE M 441.1-1, Nuclear Materials Packaging Manual on March 7, 2008 in response to the Defense Nuclear Facilities Safety Board Recommendation 2005-1. The Manual directs DOE facilities to follow detailed packaging requirements to protect workers from exposure to nuclear materials stored outside of approved engineered-contamination barriers. Los Alamos National Laboratory has identified the activities that will be performed to bring LANL into compliance with DOE M 441.1-1. These include design, qualification and procurement of new containers, repackaging based on a risk-ranking methodology, surveillance and maintenance of containers, and database requirements. The primary purpose is to replace the out-dated nuclear material storage containers with more robust containers that meet present day safety and quality standards. The repackaging campaign is supported by an integrated risk reduction methodology to prioritize the limited resources to the highest risk containers. This methodology is systematically revised and updated based on the collection of package integrity data. A set of seven nested packages with built-in filters have been designed. These range in size from 1 qt. to 10 gallon. Progress of the testing to meet Manual requirements will be given. Due to the number of packages at LANL, repackaging to achieve full compliance will take five to seven years.

Impact of aircraft systems within aircraft operation: A MEA trajectory optimisation study

OpenAIRE

Seresinhe, R.

2014-01-01

Air transport has been a key component of the socio-economic globalisation. The ever increasing demand for air travel and air transport is a testament to the success of the aircraft. But this growing demand presents many challenges. One of which is the environmental impact due to aviation. The scope of the environmental impact of aircraft can be discussed from many viewpoints. This research focuses on the environmental impact due to aircraft operation. Aircraft operation causes...

77 FR 65823 - Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures

Science.gov (United States)

2012-10-31

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 87 [EPA-HQ-OAR-2010-0687; FRL-9678-1] RIN 2060-AO70 Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures Correction In rule document 2012-13828 appearing on pages 36341-36386 in the issue of Monday, June 18, 2012, make the following corrections: Sec. 87.2...

Aircraft to aircraft intercomparison during SEMAPHORE

Science.gov (United States)

Lambert, Dominique; Durand, Pierre

1998-10-01

During the Structure des Echanges Mer-Atmosphère, Propriétés des Hétérogénéités Océaniques: Recherche Expérimentale (SEMAPHORE) experiment, performed in the Azores region in 1993, two French research aircraft were simultaneously used for in situ measurements in the atmospheric boundary layer. We present the results obtained from one intercomparison flight between the two aircraft. The mean parameters generally agree well, although the temperature has to be slightly shifted in order to be in agreement for the two aircraft. A detailed comparison of the turbulence parameters revealed no bias. The agreement is good for variances and is satisfactory for fluxes and skewness. A thorough study of the errors involved in flux computation revealed that the greatest accuracy is obtained for latent heat flux. Errors in sensible heat flux are considerably greater, and the worst results are obtained for momentum flux. The latter parameter, however, is more accurate than expected from previous parameterizations.

Environmental Aspects of Aircraft and Airfield Deicing - An Air Force Perspective

Science.gov (United States)

2010-11-01

e l l e n c e COD of Aircraft Deicers ADF Kg O2/Kg compd Ethylene glycol 1.14 T Propylene glycol 1.47 T Isopropyl alcohol 2.11 T Neopentyl glycol ...showed that commercial airports use about 25 million gallons of Aircraft Deicing Fluid (ADF) annually, of which 22.1 M (88%) is Propylene Glycol (PG...S e r v i c e - E x c e l l e n c e AF Aircraft Deicing Overview 70% (107) of bases reported using aircraft deicers Propylene Glycol (PG), AMS 1424

Development and experimental characterization of a fuel cell powered aircraft

Energy Technology Data Exchange (ETDEWEB)

Bradley, Thomas H.; Moffitt, Blake A.; Mavris, Dimitri N.; Parekh, David E. [Georgia Institute of Technology, Atlanta, GA 30332-0405 (United States)

2007-09-27

This paper describes the characteristics and performance of a fuel cell powered unmanned aircraft. The aircraft is novel as it is the largest compressed hydrogen fuel cell powered airplane built to date and is currently the only fuel cell aircraft whose design and test results are in the public domain. The aircraft features a 500 W polymer electrolyte membrane fuel cell with full balance of plant and compressed hydrogen storage incorporated into a custom airframe. Details regarding the design requirements, implementation and control of the aircraft are presented for each major aircraft system. The performances of the aircraft and powerplant are analyzed using data from flights and laboratory tests. The efficiency and component power consumption of the fuel cell propulsion system are measured at a variety of flight conditions. The performance of the aircraft powerplant is compared to other 0.5-1 kW-scale fuel cell powerplants in the literature and means of performance improvement for this aircraft are proposed. This work represents one of the first studies of fuel cell powered aircraft to result in a demonstration aircraft. As such, the results of this study are of practical interest to fuel cell powerplant and aircraft designers. (author)

Proposed plan for the K-Area Bingham Pump Outage Pit (643-1G)

International Nuclear Information System (INIS)

Palmer, E.

1997-06-01

This Proposed Plan is issued by the U.S. Department of Energy (DOE), which functions as the lead agency for SRS remedial activities, and with concurrence by the U.S. Environmental Protection Agency (EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC). The purpose of this Proposed Plan is to describe the preferred remedial alternative for addressing the K-Area Bingham Pump Outage Pit (643-1G) (K BPOP) located at the Savannah River Site (SRS) in Aiken, South Carolina and to solicit public comments on the preferred alternative

Results of the independent radiological verification survey at the former Associate Aircraft Tool and Manufacturing Company site, Fairfield, Ohio (FOH001)

International Nuclear Information System (INIS)

Rice, D.E.; Murray, M.E.; Brown, K.S.

1996-01-01

The former Associate Aircraft Tool and Manufacturing Company site is located at 3550 Dixie Highway, Fairfield, Ohio. Associate Aircraft Tool and Manufacturing Company produced hollow uranium slugs in a machine shop at the site in 1956. The work was performed for National Lead of Ohio in a contract with the Atomic Energy Commission to augment the capacity of the Feed Materials Production Center at Fernald in the development of nuclear energy for defense-related projects. The current occupant of the building, Force Control, operates a multipurpose machine shop. At the request of the US Department of Energy (DOE), a team from Oak Ridge National Laboratory conducted an independent radiological verification survey at the former Associate Aircraft Tool and Manufacturing Company Site, Fairfield, Ohio. The survey was performed from February to May of 1995. The purpose of the survey was to verify that radioactivity from residues of 238 U was remediated to a level below acceptable DOE guidelines levels

A new simulation model for assessing aircraft emergency evacuation considering passenger physical characteristics

International Nuclear Information System (INIS)

Liu, Yu; Wang, Weijie; Huang, Hong-Zhong; Li, Yanfeng; Yang, Yuanjian

2014-01-01

Conducting a real aircraft evacuation trial is oftentimes unaffordable as it is extremely expensive and may cause severe injury to participants. Simulation models as an alternative have been used to overcome the aforementioned issues in recent years. This paper proposes a new simulation model for emergency evacuation of civil aircraft. Its unique features and advantages over the existing models are twofold: (1) passengers' critical physical characteristics, e.g. waist size, gender, age, and disabilities, which impact the movement and egress time of individual evacuee from a statistical viewpoint, are taken into account in the new model. (2) Improvements are made to enhance the accuracy of the simulation model from three aspects. First, the staggered mesh discretization method together with the agent-based approach is utilized to simulate movements of individual passengers in an emergency evacuation process. Second, each node discretized to represent cabin space in the new model can contain more than one passenger if they are moving in the same direction. Finally, each individual passenger is able to change his/her evacuation route in a real-time manner based upon the distance from the current position to the target exit and the queue length. The effectiveness of the proposed simulation model is demonstrated on Boeing 767-300 aircraft. - Highlights: • A new simulation model of aircraft emergency evacuation is developed. • Some critical physical characteristics of passengers', e.g. waist size, gender, age, and disabilities, are taken into account in the new model. • An agent-based approach along with a multi-level fine network representation is used. • Passengers are able to change their evacuation routes in a real-time manner based upon distance and length of queue

14 CFR 13.17 - Seizure of aircraft.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Seizure of aircraft. 13.17 Section 13.17... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Legal Enforcement Actions § 13.17 Seizure of aircraft. (a) Under... officer, or a Federal Aviation Administration safety inspector, authorized in an order of seizure issued...

Turboelectric Distributed Propulsion Engine Cycle Analysis for Hybrid-Wing-Body Aircraft

Science.gov (United States)

Felder, James L.; Kim, Hyun Dae; Brown, Gerald V.

2009-01-01

Meeting NASA's N+3 goals requires a fundamental shift in approach to aircraft and engine design. Material and design improvements allow higher pressure and higher temperature core engines which improve the thermal efficiency. Propulsive efficiency, the other half of the overall efficiency equation, however, is largely determined by the fan pressure ratio (FPR). Lower FPR increases propulsive efficiency, but also dramatically reduces fan shaft speed through the combination of larger diameter fans and reduced fan tip speed limits. The result is that below an FPR of 1.5 the maximum fan shaft speed makes direct drive turbines problematic. However, it is the low pressure ratio fans that allow the improvement in propulsive efficiency which, along with improvements in thermal efficiency in the core, contributes strongly to meeting the N+3 goals for fuel burn reduction. The lower fan exhaust velocities resulting from lower FPRs are also key to meeting the aircraft noise goals. Adding a gear box to the standard turbofan engine allows acceptable turbine speeds to be maintained. However, development of a 50,000+ hp gearbox required by fans in a large twin engine transport aircraft presents an extreme technical challenge, therefore another approach is needed. This paper presents a propulsion system which transmits power from the turbine to the fan electrically rather than mechanically. Recent and anticipated advances in high temperature superconducting generators, motors, and power lines offer the possibility that such devices can be used to transmit turbine power in aircraft without an excessive weight penalty. Moving to such a power transmission system does more than provide better matching between fan and turbine shaft speeds. The relative ease with which electrical power can be distributed throughout the aircraft opens up numerous other possibilities for new aircraft and propulsion configurations and modes of operation. This paper discusses a number of these new

Proceedings of the FAA-NASA symposium on the continued airworthiness of aircraft structures : part 1

Science.gov (United States)

1997-07-01

This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of : Aircraft Structu...

Influence of plasminogen activator inhibitor-1 (SERPINE1) 4G/5G polymorphism on circulating SERPINE-1 antigen expression in HCC associated with viral infection.

Science.gov (United States)

Divella, Rosa; Mazzocca, Antonio; Gadaleta, Cosimo; Simone, Giovanni; Paradiso, Angelo; Quaranta, Michele; Daniele, Antonella

2012-01-01

Hepatocarcinogenesis is heavily influenced by chronic hepatitis B (HBV) and C (HCV) infection. Elevated levels of plasminogen activator inhibitor-1 (SERPINE1/PAI-1) have been reported in patients with hepatocellular carcinoma (HCC) associated with viral infection. The gene encoding SERPINE1 is highly polymorphic and the frequently associated 4/5 guanosine (4G/5G) polymorphism in the gene promoter may influence its expression. Here, we investigated the distribution of genotypes and the frequency of alleles of the 4G/5G polymorphism in patients with HCC, the influence of the 4G/5G polymorphism on plasma SERPINE1 levels and its association with viral infection. A total of 75 patients with HCC were enrolled: 32 (42.6%) were HBV(+)/HCV(+), 11 (14.6%) were only HCV(+), and 32 (42.6%) were negative for both viruses. A control group of healthy donors was also enrolled (n=50). SERPINE1 plasma concentrations were determined by ELISA and the detection of the promoter 4G/5G polymorphism was performed by an allele-specific PCR analysis. We found that the frequency of both the 4G/4G genotype (p=0.02) and the 4G allele (p=0.006) were significantly higher in patients with HCC compared to the control group, and particularly higher in patients with HCC co-infected with HBV(+)/HCV(+) than in those with no viral infection. We also found that patients with the 4G/4G genotype had significantly higher plasma SERPINE1 protein levels when compared with patients with the 4G/5G or 5G/5G genotype (p5G SERPINE1 polymorphism with a higher level of SERPINE1 protein in patients with HCC with HBV(+)/HCV(+) than those without infection, suggest the presence of two distinct pathogenic mechanisms in hepatocarcinogenesis, depending on the etiology.

Analysis of Turbofan Design Options for an Advanced Single-Aisle Transport Aircraft

Science.gov (United States)

Guynn, Mark D.; Berton, Jeffrey J.; Fisher, Kenneth L.; Haller, William J.; Tong, Michael T.; Thurman, Douglas R.

2009-01-01

The desire for higher engine efficiency has resulted in the evolution of aircraft gas turbine engines from turbojets, to low bypass ratio, first generation turbofans, to today's high bypass ratio turbofans. It is possible that future designs will continue this trend, leading to very-high or ultra-high bypass ratio (UHB) engines. Although increased bypass ratio has clear benefits in terms of propulsion system metrics such as specific fuel consumption, these benefits may not translate into aircraft system level benefits due to integration penalties. In this study, the design trade space for advanced turbofan engines applied to a single-aisle transport (737/A320 class aircraft) is explored. The benefits of increased bypass ratio and associated enabling technologies such as geared fan drive are found to depend on the primary metrics of interest. For example, bypass ratios at which fuel consumption is minimized may not require geared fan technology. However, geared fan drive does enable higher bypass ratio designs which result in lower noise. Regardless of the engine architecture chosen, the results of this study indicate the potential for the advanced aircraft to realize substantial improvements in fuel efficiency, emissions, and noise compared to the current vehicles in this size class.

Formal Methods in Air Traffic Management: The Case of Unmanned Aircraft Systems

Science.gov (United States)

Munoz, Cesar A.

2015-01-01

As the technological and operational capabilities of unmanned aircraft systems (UAS) continue to grow, so too does the need to introduce these systems into civil airspace. Unmanned Aircraft Systems Integration in the National Airspace System is a NASA research project that addresses the integration of civil UAS into non-segregated airspace operations. One of the major challenges of this integration is the lack of an onboard pilot to comply with the legal requirement that pilots see and avoid other aircraft. The need to provide an equivalent to this requirement for UAS has motivated the development of a detect and avoid (DAA) capability to provide the appropriate situational awareness and maneuver guidance in avoiding and remaining well clear of traffic aircraft. Formal methods has played a fundamental role in the development of this capability. This talk reports on the formal methods work conducted under NASA's Safe Autonomous System Operations project in support of the development of DAA for UAS. This work includes specification of low-level and high-level functional requirements, formal verification of algorithms, and rigorous validation of software implementations. The talk also discusses technical challenges in formal methods research in the context of the development and safety analysis of advanced air traffic management concepts.

Testing and Analysis of a Composite Non-Cylindrical Aircraft Fuselage Structure. Part 1; Ultimate Design Loads

Science.gov (United States)

Przekop, Adam; Jegley, Dawn C.; Lovejoy, Andrew E.; Rouse, Marshall; Wu, Hsi-Yung T.

2016-01-01

The Environmentally Responsible Aviation Project aimed to develop aircraft technologies enabling significant fuel burn and community noise reductions. Small incremental changes to the conventional metallic alloy-based 'tube and wing' configuration were not sufficient to achieve the desired metrics. One airframe concept identified by the project as having the potential to dramatically improve aircraft performance was a composite-based hybrid wing body configuration. Such a concept, however, presented inherent challenges stemming from, among other factors, the necessity to transfer wing loads through the entire center fuselage section which accommodates a pressurized cabin confined by flat or nearly flat panels. This paper discusses finite element analysis and testing of a large-scale hybrid wing body center section structure developed and constructed to demonstrate that the Pultruded Rod Stitched Efficient Unitized Structure concept can meet these challenging demands of the next generation airframes. Part I of the paper considers the five most critical load conditions, which are internal pressure only and positive and negative g-loads with and without internal pressure. Analysis results are compared with measurements acquired during testing. Performance of the test article is found to be closely aligned with predictions and, consequently, able to support the hybrid wing body design loads in pristine and barely visible impact damage conditions.

12 CFR 516.1 - What does this part do?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What does this part do? 516.1 Section 516.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES § 516.1 What does this part do? (a) This part explains OTS procedures for processing applications...

Air Traffic Security: Aircraft Classification Using ADS-B Message’s Phase-Pattern

Directory of Open Access Journals (Sweden)

Mauro Leonardi

2017-10-01

Full Text Available Automatic Dependent Surveillance-Broadcast (ADS-B is a surveillance system used in Air Traffic Control. With this system, the aircraft transmits their own information (identity, position, velocity, etc. to any equipped listener for surveillance scope. The ADS-B is based on a very simple protocol and does not provide any kind of authentication and encryption, making it vulnerable to many types of cyber-attacks. In the paper, the use of the airplane/transmitter carrier phase is proposed as a feature to perform a classification of the aircraft and, therefore, distinguish legitimate messages from fake ones. The feature extraction process is described and a classification method is selected. Finally, a complete intruder detection algorithm is proposed and evaluated with real data.

In-flight Fault Detection and Isolation in Aircraft Flight Control Systems

Science.gov (United States)

Azam, Mohammad; Pattipati, Krishna; Allanach, Jeffrey; Poll, Scott; Patterson-Hine, Ann

2005-01-01

In this paper we consider the problem of test design for real-time fault detection and isolation (FDI) in the flight control system of fixed-wing aircraft. We focus on the faults that are manifested in the control surface elements (e.g., aileron, elevator, rudder and stabilizer) of an aircraft. For demonstration purposes, we restrict our focus on the faults belonging to nine basic fault classes. The diagnostic tests are performed on the features extracted from fifty monitored system parameters. The proposed tests are able to uniquely isolate each of the faults at almost all severity levels. A neural network-based flight control simulator, FLTZ(Registered TradeMark), is used for the simulation of various faults in fixed-wing aircraft flight control systems for the purpose of FDI.

12 CFR 559.1 - What does this part cover?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What does this part cover? 559.1 Section 559.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SUBORDINATE ORGANIZATIONS § 559.1 What does this part cover? (a) OTS is issuing this part 559 pursuant to its general rulemaking...

Organic positive ions in aircraft gas-turbine engine exhaust

Science.gov (United States)

Sorokin, Andrey; Arnold, Frank

Volatile organic compounds (VOCs) represent a significant fraction of atmospheric aerosol. However the role of organic species emitted by aircraft (as a consequence of the incomplete combustion of fuel in the engine) in nucleation of new volatile particles still remains rather speculative and requires a much more detailed analysis of the underlying mechanisms. Measurements in aircraft exhaust plumes have shown the presence of both different non-methane VOCs (e.g. PartEmis project) and numerous organic cluster ions (MPIK-Heidelberg). However the link between detected organic gas-phase species and measured mass spectrum of cluster ions is uncertain. Unfortunately, up to now there are no models describing the thermodynamics of the formation of primary organic cluster ions in the exhaust of aircraft engines. The aim of this work is to present first results of such a model development. The model includes the block of thermodynamic data based on proton affinities and gas basicities of organic molecules and the block of non-equilibrium kinetics of the cluster ions evolution in the exhaust. The model predicts important features of the measured spectrum of positive ions in the exhaust behind aircraft. It is shown that positive ions emitted by aircraft engines into the atmosphere mostly consist of protonated and hydrated organic cluster ions. The developed model may be explored also in aerosol investigations of the background atmosphere as well as in the analysis of the emission of fine aerosol particles by automobiles.

An Analysis of Coordinated Observations from NOAA’s Ronald H. Brown Ship and G-IV Aircraft in a Landfalling Atmospheric River over the North Pacific during CalWater-2015

Energy Technology Data Exchange (ETDEWEB)

Neiman, Paul J. [Physical Sciences Division, NOAA/Earth System Research Laboratory, Boulder, Colorado; Gaggini, Natalie [Science and Technology Corporation, and NOAA/Earth System Research Laboratory, Boulder, Colorado; Fairall, Christopher W. [Physical Sciences Division, NOAA/Earth System Research Laboratory, Boulder, Colorado; Aikins, Joshua [Cooperative Institute for Research in the Environmental Sciences, and NOAA/Earth System Research Laboratory, Boulder, Colorado; Spackman, J. Ryan [Science and Technology Corporation, and NOAA/Earth System Research Laboratory, Boulder, Colorado; Leung, L. Ruby [Pacific Northwest National Laboratory, Richland, Washington; Fan, Jiwen [Pacific Northwest National Laboratory, Richland, Washington; Hardin, Joseph [Pacific Northwest National Laboratory, Richland, Washington; Nalli, Nicholas R. [I. M. Systems Group, NOAA/NESDIS/STAR, College Park, Maryland; White, Allen B. [Physical Sciences Division, NOAA/Earth System Research Laboratory, Boulder, Colorado

2017-09-01

Using a diverse suite of mobile observing platforms deployed on NOAA’s Ronald H. Brown (RHB) research vessel and G-IV research aircraft during the CalWater-2015 field campaign, this study describes the structure and evolution of a long-lived atmospheric river (AR) modulated by six frontal waves over the northeastern Pacific on 20-25 January 2015. Satellite observations and reanalysis diagnostics provided synoptic-scale context, illustrating the warm, moist southwesterly airstream within the quasi-stationary AR situated between an upper-level trough and ridge. The AR remained offshore of the U.S. West Coast but made landfall across British Columbia where heavy precipitation and high melting levels occurred, resulting in flooding. Forty-seven rawinsondes launched from the RHB provided a comprehensive thermodynamic and kinematic depiction of the AR, including an upward intrusion of strong water-vapor transport in the low-level moist southwesterly flow during the passage of frontal waves 2 through 6. A collocated 1290-MHz wind profiler showed an abrupt frontal transition from southwesterly to northerly flow below 1 km MSL coinciding with the tail-end of AR conditions. Shipborne radar and disdrometer observations in the AR uniquely captured key microphysical characteristics of shallow warm rain, convection, and deep mixed-phase precipitation. Continuous and novel observations of sea-surface fluxes documented persistent ocean-surface evaporation into the AR and sensible-heat transfer from the AR into the ocean. The G-IV aircraft coordinated with the RHB and flew directly over the ship. Dropsonde and radar spatial analyses complemented the temporal depictions of the AR from the RHB. The AR characteristics varied, depending on the location of the cross section through the frontal waves.

Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans.

Directory of Open Access Journals (Sweden)

Leonie M Kamminga

Full Text Available RNA interference (RNAi-related pathways affect gene activity by sequence-specific recruitment of Ago proteins to mRNA target molecules. The sequence specificity of this process stems from small RNA (sRNA co-factors bound by the Ago protein. Stability of sRNA molecules in some pathways is in part regulated by Hen1-mediated methylation of their 3' ends. Here we describe the effects of the Caenorhabditis elegans HEN1 RNA-methyl-transferase homolog, HENN-1, on the different RNAi pathways in this nematode. We reveal differential effects of HENN-1 on the two pathways that are known to employ methylated sRNA molecules: the 26G and 21U pathways. Surprisingly, in the germline, stability of 21U RNAs, the C. elegans piRNAs, is only mildly affected by loss of methylation; and introduction of artificial 21U target RNA does not further destabilize non-methylated 21U RNAs. In contrast, most 26G RNAs display reduced stability and respond to loss of HENN-1 by displaying increased 3'-uridylation frequencies. Within the 26G RNA class, we find that specifically ERGO-1-bound 26G RNAs are modified by HENN-1, while ALG-3/ALG-4-bound 26G RNAs are not. Global gene expression analysis of henn-1 mutants reveals mild effects, including down-regulation of many germline-expressed genes. Our data suggest that, apart from direct effects of reduced 26G RNA levels of henn-1 on gene expression, most effects on global gene expression are indirect. These studies further refine our understanding of endogenous RNAi in C. elegans and the roles for Hen1 like enzymes in these pathways.

COMPARATIVE ANALYSIS OF TRANSPORT AIRCRAFT, BACKROUND FOR SHORT/ MEDIUM COURIER TRANSPORT AIRCRAFT PROCUREMENT

Directory of Open Access Journals (Sweden)

Matei POPA

2010-03-01

Full Text Available In accordance with Air Force requirements, the comparative analysis of short/medium transport aircraft comes to sustain procurement decision of short/medium transport aircraft. This paper presents, in short, the principles and the results of the comparative analysis for short/medium military transport aircraft.

12 CFR 557.1 - What does this part do?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What does this part do? 557.1 Section 557.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEPOSITS General § 557.1 What does this part do? This part applies to the deposit activities of savings associations. If you are a...

Molecular Characterization of Echinococcus granulosus Cysts in North Indian Patients: Identification of G1, G3, G5 and G6 Genotypes

Science.gov (United States)

Sharma, Monika; Sehgal, Rakesh; Fomda, Bashir Ahmad; Malhotra, Anil; Malla, Nancy

2013-01-01

Background Cystic echinococcosis (CE) caused by the Echinococcus granulosus, is a major public health problem worldwide, including India. The different genotypes of E. granulosus responsible for human hydatidosis have been reported from endemic areas throughout the world. However, the genetic characterization of E. granulosus infecting the human population in India is lacking. The aim of study was to ascertain the genotype(s) of the parasite responsible for human hydatidosis in North India. Methodology/Principal Findings To study the transmission patterns of E. granulosus, genotypic analysis was performed on hydatid cysts obtained from 32 cystic echinococcosis (CE) patients residing in 7 different states of North India. Mitochondrial cytochrome c oxidase subunit1 (cox1) sequencing was done for molecular identification of the isolates. Most of the CE patients (30/32) were found to be infected with hydatid cyst of either G3 (53.1%) or G1 (40.62%) genotype and one each of G5 (cattle strain) and G6 (camel strain) genotype. Conclusions/Significance These findings demonstrate the zoonotic potential of G1 (sheep strain) and G3 (buffalo strain) genotypes of E. granulosus as these emerged as predominant genotypes infecting the humans in India. In addition to this, the present study reports the first human CE case infected with G5 genotype (cattle strain) in an Asian country and presence of G6 genotype (camel strain) in India. The results may have important implications in the planning of control strategies for human hydatidosis. PMID:23785531

SOLAR AIRCRAFT DESIGN

OpenAIRE

RAHMATI, Sadegh; GHASED, Amir

2015-01-01

Abstract. Generally domain Aircraft uses conventional fuel. These fuel having limited life, high cost and pollutant. Also nowadays price of petrol and other fuels are going to be higher, because of scarcity of those fuels. So there is great demand of use of non-exhaustible unlimited source of energy like solar energy. Solar aircraft is one of the ways to utilize solar energy. Solar aircraft uses solar panel to collect the solar radiation for immediate use but it also store the remaining part ...

49 CFR 173.172 - Aircraft hydraulic power unit fuel tank.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Aircraft hydraulic power unit fuel tank. 173.172... Class 1 and Class 7 § 173.172 Aircraft hydraulic power unit fuel tank. Aircraft hydraulic power unit fuel tanks containing a mixture of anhydrous hydrazine and monomethyl hydrazine (M86 fuel) and designed...

78 FR 35085 - Consensus Standards, Light-Sport Aircraft

Science.gov (United States)

2013-06-11

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Consensus Standards, Light-Sport... to the provisions of the Sport Pilot and Light-Sport Aircraft rule issued July 16, 2004, and effective September 1, 2004. ASTM International Committee F37 on Light Sport Aircraft developed the new and...

77 FR 24251 - Consensus Standards, Light-Sport Aircraft

Science.gov (United States)

2012-04-23

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Consensus Standards, Light-Sport... relating to the provisions of the Sport Pilot and Light-Sport Aircraft rule issued July 16, 2004, and effective September 1, 2004. ASTM International Committee F37 on Light Sport Aircraft developed the new and...

O{sub 2}(X{sup 3}Σ{sub g}{sup −}) and O{sub 2}(a{sup 1}Δ{sub g}) charge exchange with simple ions

Energy Technology Data Exchange (ETDEWEB)

Ziółkowski, Marcin; Schatz, George C., E-mail: schatz@chem.northwestern.edu [Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113 (United States); Viggiano, A. A.; Midey, Anthony [Air Force Research Laboratory, Space Vehicles Directorate, 3500 Aberdeen Ave, Kirtland AFB, New Mexico 87117 (United States); Dotan, Itzhak [Air Force Research Laboratory, Space Vehicles Directorate, 3500 Aberdeen Ave, Kirtland AFB, New Mexico 87117 (United States); Open University of Israel, 108 Ravutski St., Raanana 43107 (Israel)

2014-06-07

We present theory and experiments which describe charge transfer from the X{sup 3}Σ{sub g}{sup −} and a{sup 1}Δ{sub g} states of molecular oxygen and atomic and molecular cations. Included in this work are new experimental results for O{sub 2}(a{sup 1}Δ{sub g}) and the cations O{sup +}, CO{sup +}, Ar{sup +}, and N{sub 2}{sup +}, and new theory based on complete active space self-consistent field method calculations and an extended Langevin model to calculate rate constants for ground and excited O{sub 2} reacting with the atomic ions Ar{sup +}, Kr{sup +}, Xe{sup +}, Cl{sup +}, and Br{sup +}. The T-shaped orientation of the (X − O{sub 2}){sup +} potential surface is used for the calculations, including all the low lying states up to the second singlet state of the oxygen molecule b{sup 1}Σ{sub g}{sup +}. The calculated rate constants for both O{sub 2}(X{sup 3}Σ{sub g}{sup −}) and O{sub 2}(a{sup 1}Δ{sub g}) show consistent trends with the experimental results, with a significant dependence of rate constant on charge transfer exothermicity that does not depend strongly on the nature of the cation. The comparisons with theory show that partners with exothermicities of about 1 eV have stronger interactions with O{sub 2}, leading to larger Langevin radii, and also that more of the electronic states are attractive rather than repulsive, leading to larger rate constants. Rate constants for charge transfer involving O{sub 2}(a{sup 1}Δ{sub g}) are similar to those for O{sub 2}(X{sup 3}Σ{sub g}{sup −}) for a given exothermicity ignoring the electronic excitation of the O{sub 2}(a{sup 1}Δ{sub g}) state. This means (and the electronic structure calculations support) that the ground and excited states of O{sub 2} have about the same attractive interactions with ions.

Design definition study of a lift/cruise fan technology V/STOL aircraft. Volume 2: Technology aircraft

Science.gov (United States)

1975-01-01

Technology flight vehicles were defined for three different approaches which demonstrate the concept and characteristics of the multipurpose aircraft established for Navy missions. The propulsion system used for the various technology flight vehicles was representative of that established for the multipurpose aircraft. Existing J97-GE100 gas generators were selected based on cost, availability and exhaust characteristics. The LF459 fans were also selected and are compatible with both technology and operational vehicles. To comply with the design guideline safety criteria, it was determined that three gas generators were required to provide engine out safety in the hover flight mode. The final propulsion system established for the technology aircraft was three existing J97 gas generators powering three LF459 fans. Different aircraft candidates were evaluated for application to the three designated design approaches. Each configuration was evaluated on the basis of (1) propulsion system integration, (2) modification required, (3) pilot's visibility, (4) payload volume, and (5) adaptability to compatible location of center-of-gravity/aerodynamic center and thrust center.

Aircraft operations management manual

Science.gov (United States)

1992-01-01

The NASA aircraft operations program is a multifaceted, highly diverse entity that directly supports the agency mission in aeronautical research and development, space science and applications, space flight, astronaut readiness training, and related activities through research and development, program support, and mission management aircraft operations flights. Users of the program are interagency, inter-government, international, and the business community. This manual provides guidelines to establish policy for the management of NASA aircraft resources, aircraft operations, and related matters. This policy is an integral part of and must be followed when establishing field installation policy and procedures covering the management of NASA aircraft operations. Each operating location will develop appropriate local procedures that conform with the requirements of this handbook. This manual should be used in conjunction with other governing instructions, handbooks, and manuals.

Measurement of the Proton and Deuteron Spin Structure Functions G1 and G2

Energy Technology Data Exchange (ETDEWEB)

Tobias, Al

2003-04-02

The SLAC experiment E155 was a deep-inelastic scattering experiment that scattered polarized electrons off polarized proton and deuteron targets in the effort to measure precisely the proton and deuteron spin structure functions. The nucleon structure functions g{sub 1} and g{sub 2} are important quantities that help test our present models of nucleon structure. Such information can help quantify the constituent contributions to the nucleon spin. The structure functions g{sub 1}{sup p} and G{sub 1}{sup d} have been measured over the kinematic range 0.01 {le} x {le} 0.9 and 1 {le} Q{sup 2} {le} 40 GeV{sup 2} by scattering 48.4 GeV longitudinally polarized electrons off longitudinally polarized protons and deuterons. In addition, the structure functions g{sub 2}{sup p} and g{sub 2}{sup d} have been measured over the kinematic range 0.01 {le} x {le} 0.7 and 1 {le} Q{sup 2} {le} 17 GeV{sup 2} by scattering 38.8 GeV longitudinally polarized electrons off transversely polarized protons and deuterons. The measurements of g{sub 1} confirm the Bjorken sum rule and find the net quark polarization to be {Delta}{Sigma} = 0.23 {+-} 0.04 {+-} 0.6 while g{sub 2} is found to be consistent with the g{sub 2}{sup WW} model.

Analysis of Radar and ADS-B Influences on Aircraft Detect and Avoid (DAA Systems

Directory of Open Access Journals (Sweden)

William Semke

2017-09-01

Full Text Available Detect and Avoid (DAA systems are complex communication and locational technologies comprising multiple independent components. DAA technologies support communications between ground-based and space-based operations with aircraft. Both manned and unmanned aircraft systems (UAS rely on DAA communication and location technologies for safe flight operations. We examined the occurrence and duration of communication losses between radar and automatic dependent surveillance–broadcast (ADS-B systems with aircraft operating in proximate airspace using data collected during actual flight operations. Our objectives were to identify the number and duration of communication losses for both radar and ADS-B systems that occurred within a discrete time period. We also investigated whether other unique communication behavior and anomalies were occurring, such as reported elevation deviations. We found that loss of communication with both radar and ADS-B systems does occur, with variation in the length of communication losses. We also discovered that other unexpected behaviors were occurring with communications. Although our data were gathered from manned aircraft, there are also implications for UAS that are operating within active airspaces. We are unaware of any previously published work on occurrence and duration of communication losses between radar and ADS-B systems.

Leakage Account for Radial Face Contact Seal in Aircraft Engine Support

Science.gov (United States)

Vinogradov, A. S.; Sergeeva, T. V.

2018-01-01

The article is dedicated to the development of a methodology for the radial face contact seal design taking into consideration the supporting elements deformations in different aircraft engine operating modes. Radial face contact seals are popular in the aircraft engines bearing support. However, there are no published leakage calculation methodologies of these seals. Radial face contact seal leakage is determined by the gap clearance in the carbon seal ring split. In turn, the size gap clearance depends on the deformation of the seal assembly parts and from the engine operation. The article shows the leakage detection sequence in the intershaft radial face contact seal of the compressor support for take-off and cruising modes. Evaluated calculated leakage values (2.4 g/s at takeoff and 0.75 g/s at cruising) go with experience in designing seals.

A study of low-cost reliable actuators for light aircraft. Part A: Chapters 1-8

Science.gov (United States)

Eijsink, H.; Rice, M.

1978-01-01

An analysis involving electro-mechanical, electro-pneumatic, and electro-hydraulic actuators was performed to study which are compatible for use in the primary and secondary flight controls of a single engine light aircraft. Actuator characteristics under investigation include cost, reliability, weight, force, volumetric requirements, power requirements, response characteristics and heat accumulation characteristics. The basic types of actuators were compared for performance characteristics in positioning a control surface model and then were mathematically evaluated in an aircraft to get the closed loop dynamic response characteristics. Conclusions were made as to the suitability of each actuator type for use in an aircraft.

A fuselage/tank structure study for actively cooled hypersonic cruise vehicles, summary. [aircraft design of aircraft fuel systems

Science.gov (United States)

Pirrello, C. J.; Baker, A. H.; Stone, J. E.

1976-01-01

A detailed analytical study was made to investigate the effects of fuselage cross section (circular and elliptical) and the structural arrangement (integral and nonintegral tanks) on aircraft performance. The vehicle was a 200 passenger, liquid hydrogen fueled Mach 6 transport designed to meet a range goal of 9.26 Mn (5000 NM). A variety of trade studies were conducted in the area of configuration arrangement, structural design, and active cooling design in order to maximize the performance of each of three point design aircraft: (1) circular wing-body with nonintegral tanks, (2) circular wing-body with integral tanks and (3) elliptical blended wing-body with integral tanks. Aircraft range and weight were used as the basis for comparison. The resulting design and performance characteristics show that the blended body integral tank aircraft weights the least and has the greatest range capability, however, producibility and maintainability factors favor nonintegral tank concepts.

Conceptual design of high speed supersonic aircraft: A brief review on SR-71 (Blackbird) aircraft

Science.gov (United States)

Xue, Hui; Khawaja, H.; Moatamedi, M.

2014-12-01

The paper presents the conceptual design of high-speed supersonic aircraft. The study focuses on SR-71 (Blackbird) aircraft. The input to the conceptual design is a mission profile. Mission profile is a flight profile of the aircraft defined by the customer. This paper gives the SR-71 aircraft mission profile specified by US air force. Mission profile helps in defining the attributes the aircraft such as wing profile, vertical tail configuration, propulsion system, etc. Wing profile and vertical tail configurations have direct impact on lift, drag, stability, performance and maneuverability of the aircraft. A propulsion system directly influences the performance of the aircraft. By combining the wing profile and the propulsion system, two important parameters, known as wing loading and thrust to weight ratio can be calculated. In this work, conceptual design procedure given by D. P. Raymer (AIAA Educational Series) is applied to calculate wing loading and thrust to weight ratio. The calculated values are compared against the actual values of the SR-71 aircraft. Results indicates that the values are in agreement with the trend of developments in aviation.

Aircraft noise: accounting for changes in air traffic with time of day.

Science.gov (United States)

Schäffer, Beat; Bütikofer, Rudolf; Plüss, Stefan; Thomann, Georg

2011-01-01

Aircraft noise contours are estimated using model calculations and, due to their impact on land use planning, they need to be highly accurate. During night time, not only the number and dominant types of aircraft may differ from daytime but also the flight paths flown may differ. To determine to which detail these variations in flight paths need to be considered, calculations were performed exemplarily for two airports using all available radar data over 1 year, taking into account their changes over the day. The results of this approach were compared with results of a simpler approach which does not consider such changes. While both calculations yielded similar results for the day and close to the airport, differences increased with distance as well as with the period of day (day

Molecular characterization of Echinococcus granulosus cysts in north Indian patients: identification of G1, G3, G5 and G6 genotypes.

Directory of Open Access Journals (Sweden)

Monika Sharma

Full Text Available BACKGROUND: Cystic echinococcosis (CE caused by the Echinococcus granulosus, is a major public health problem worldwide, including India. The different genotypes of E. granulosus responsible for human hydatidosis have been reported from endemic areas throughout the world. However, the genetic characterization of E. granulosus infecting the human population in India is lacking. The aim of study was to ascertain the genotype(s of the parasite responsible for human hydatidosis in North India. METHODOLOGY/PRINCIPAL FINDINGS: To study the transmission patterns of E. granulosus, genotypic analysis was performed on hydatid cysts obtained from 32 cystic echinococcosis (CE patients residing in 7 different states of North India. Mitochondrial cytochrome c oxidase subunit1 (cox1 sequencing was done for molecular identification of the isolates. Most of the CE patients (30/32 were found to be infected with hydatid cyst of either G3 (53.1% or G1 (40.62% genotype and one each of G5 (cattle strain and G6 (camel strain genotype. CONCLUSIONS/SIGNIFICANCE: These findings demonstrate the zoonotic potential of G1 (sheep strain and G3 (buffalo strain genotypes of E. granulosus as these emerged as predominant genotypes infecting the humans in India. In addition to this, the present study reports the first human CE case infected with G5 genotype (cattle strain in an Asian country and presence of G6 genotype (camel strain in India. The results may have important implications in the planning of control strategies for human hydatidosis.

Serum-induced G0/G1 transition in chemically transformed 3T3 cells

International Nuclear Information System (INIS)

Gray, H.E.; Buchou, T.; Mester, J.

1987-01-01

Quiescent, chemically transformed (benzo-a-pyrene) BALB/c 3T3 cells (BP A31) enter the cell division cycle when exposed to complete medium containing 10% fetal calf serum (FCS); the number of cells recruited is a function of the duration of serum exposure. The recruitment of cells by short (<4 h) serum pulses is not inhibited by simultaneous exposure to cycloheximide (CH), and therefore the initial commitment does not require protein synthesis. The cells enter S phase with a constant delay following the removal of CH, even if CH exposure has been continued for as long as 20 h after the end of the serum pulse. The cell recruitment by serum pulses was inhibited by 5,6-dichloro-1-β-D-ribofuranosyl-benzimidazole (DRB), an inhibitor of cytoplasmic mRNA accumulation. These data suggest that serum exposure produces a stable memory that is necessary and sufficient for the eventual progression through G1 to S phase that occurs when protein synthesis is resumed after the removal of CH; this memory probably consists of mRNA species that are induced by serum and that are stable in the absence of protein synthesis. Unexpectedly, pretreatment of quiescent BP A31 cells with CH (8-24 h) dramatically increased the fraction of the total cell population that is recruited by a serum pulse of fixed duration

Association of the plasminogen activator inhibitor-1 (PAI-1) Gene -675 4G/5G and -844 A/G promoter polymorphism with risk of keloid in a Chinese Han population.

Science.gov (United States)

Wang, Yongjie; Long, Jianhong; Wang, Xiaoyan; Sun, Yang

2014-10-28

A keloid is pathological scar caused by aberrant response to skin injuries, characterized by excessive accumulation of histological extracellular matrix, and occurs in genetically susceptible individuals. Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of keloid. We investigated the association between PAI-1 polymorphisms and plasma PAI-1 level with keloid risk. A total of 242 Chinese keloid patients and 207 controls were enrolled in this study. Polymerase chain reaction-restriction technique was used to determine PAI-1 promoter polymorphism (-675 4G/5G and -844 A/G) distribution. Plasma PAI-1 levels were detected using enzyme-linked immunosorbent assay (ELISA). There was a statistically significant difference in the distribution of PAI-1 -675 4G/5G polymorphism between keloid patients and healthy controls. 4G/4G carriers were more likely to develop keloid. In contrast, the -844 A/G polymorphism distribution did not vary significantly between keloid patients and controls. The keloid patients group had a significantly higher plasma PAI-1 level than the control group. In the -675 4G/4G carrier population, the plasma PAI-1 levels were significant higher in keloid patients compared with controls. Our study provides evidence that PAI-1 promoter polymorphism -675 4G/5G and plasma PAI-1 level are associated with keloid risk. PAI-1 -675 4G/5G polymorphism may be an important hereditary factor responsible for keloid development in the Chinese Han population.

Crystal structure of the conserved herpesvirus fusion regulator complex gH—gL

Energy Technology Data Exchange (ETDEWEB)

Chowdary, Tirumala K.; Cairns, Tina M.; Atanasiu, Doina; Cohen, Gary H.; Eisenberg, Roselyn J.; Heldwein, Ekaterina E. [UPENN; (Tufts-MED)

2015-02-09

Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH–gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH–gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH–gL activates gB for fusion, possibly through direct binding. Formation of a gB–gH–gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB–gH–gL interface a promising antiviral target.

Solar thermal aircraft

Science.gov (United States)

Bennett, Charles L.

2007-09-18

A solar thermal powered aircraft powered by heat energy from the sun. A heat engine, such as a Stirling engine, is carried by the aircraft body for producing power for a propulsion mechanism, such as a propeller. The heat engine has a thermal battery in thermal contact with it so that heat is supplied from the thermal battery. A solar concentrator, such as reflective parabolic trough, is movably connected to an optically transparent section of the aircraft body for receiving and concentrating solar energy from within the aircraft. Concentrated solar energy is collected by a heat collection and transport conduit, and heat transported to the thermal battery. A solar tracker includes a heliostat for determining optimal alignment with the sun, and a drive motor actuating the solar concentrator into optimal alignment with the sun based on a determination by the heliostat.

Radiative forcing from particle emissions by future supersonic aircraft

Directory of Open Access Journals (Sweden)

G. Pitari

2008-07-01

Full Text Available In this work we focus on the direct radiative forcing (RF of black carbon (BC and sulphuric acid particles emitted by future supersonic aircraft, as well as on the ozone RF due to changes produced by emissions of both gas species (NO_x, H₂O and aerosol particles capable of affecting stratospheric ozone chemistry. Heterogeneous chemical reactions on the surface of sulphuric acid stratospheric particles (SSA-SAD are the main link between ozone chemistry and supersonic aircraft emissions of sulphur precursors (SO₂ and particles (H₂O–H₂SO₄. Photochemical O₃ changes are compared from four independent 3-D atmosphere-chemistry models (ACMs, using as input the perturbation of SSA-SAD calculated in the University of L'Aquila model, which includes on-line a microphysics code for aerosol formation and growth. The ACMs in this study use aircraft emission scenarios for the year 2050 developed by AIRBUS as a part of the EU project SCENIC, assessing options for fleet size, engine technology (NO_x emission index, Mach number, range and cruising altitude. From our baseline modeling simulation, the impact of supersonic aircraft on sulphuric acid aerosol and BC mass burdens is 53 and 1.5 μg/m², respectively, with a direct RF of −11.4 and 4.6 mW/m² (net RF=−6.8 mW/m². This paper discusses the similarities and differences amongst the participating models in terms of changes to O₃ precursors due to aircraft emissions (NO_x, HO_x,Cl_x,Br_x and the stratospheric ozone sensitivity to them. In the baseline case, the calculated global ozone change is −0.4 ±0.3 DU, with a net radiative forcing (IR+UV of −2.5± 2 mW/m². The fraction of this O₃-RF attributable to SSA-SAD changes is, however, highly variable among the models, depending on the NO_x removal

Advanced piloted aircraft flight control system design methodology. Volume 1: Knowledge base

Science.gov (United States)

Mcruer, Duane T.; Myers, Thomas T.

1988-01-01

The development of a comprehensive and electric methodology for conceptual and preliminary design of flight control systems is presented and illustrated. The methodology is focused on the design stages starting with the layout of system requirements and ending when some viable competing system architectures (feedback control structures) are defined. The approach is centered on the human pilot and the aircraft as both the sources of, and the keys to the solution of, many flight control problems. The methodology relies heavily on computational procedures which are highly interactive with the design engineer. To maximize effectiveness, these techniques, as selected and modified to be used together in the methodology, form a cadre of computational tools specifically tailored for integrated flight control system preliminary design purposes. While theory and associated computational means are an important aspect of the design methodology, the lore, knowledge and experience elements, which guide and govern applications are critical features. This material is presented as summary tables, outlines, recipes, empirical data, lists, etc., which encapsulate a great deal of expert knowledge. Much of this is presented in topical knowledge summaries which are attached as Supplements. The composite of the supplements and the main body elements constitutes a first cut at a a Mark 1 Knowledge Base for manned-aircraft flight control.

22 CFR 121.3 - Aircraft and related articles.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aircraft and related articles. 121.3 Section 121.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS THE UNITED STATES MUNITIONS LIST Enumeration of Articles § 121.3 Aircraft and related articles. In Category VIII...

Design Of Vertical Take-Off And Landing VTOL Aircraft System

Directory of Open Access Journals (Sweden)

Win Ko Ko Oo

2017-04-01

Full Text Available Vertical Take Off and Landing Vehicles VTOL are the ones which can take off and land from the same place without need of long runway. This paper presents the design and implementation of tricopter mode and aircraft mode for VTOL aircraft system. Firstly the aircraft design is considered for VTOL mode. And then the mathematical model of the VTOL aircraft is applied to test stability. In this research the KK 2.1 flight controller is used for VTOL mode and aircraft mode. The first part is to develop the VTOL mode and the next part is the transition of VTOL mode to aircraft mode. This paper gives brief idea about numerous types of VTOLs and their advantages over traditional aircraftsand insight to various types of tricopter and evaluates their configurations.

A MATHEMATICAL MODEL OF THE MILITARY TRANSPORT AIRCRAFT MOVEMENT AT CARGO ITEM DROP

Directory of Open Access Journals (Sweden)

2016-01-01

Full Text Available The controllability of military transport aircraft deteriorates at heavy single piece landing. To solve this problem and a specific methodology for pilotage of the pre-emption, and automation tools are being developed. Preliminary study ofpilotage technique and authomatic control algorythm demand a reliable mathematical model of aircraft dynamics at cargo item drop. Such model should take into account significant change in the position of the aircraft center of mass and aircraft inertia tensor. Simplified models were based on modeling the movement of the center of mass and rotation around the cen- ter of mass of the aircraft. Such models do not take into account the inertial forces and moments of moving a cargo item. This circumstance does not allow to obtain reliable results in the simulation. The article presents the description of the complete mathematical model of the movement of military transport aircraft in landing of a cargo item. Examines the com- plex material system of solids and a detailed description of the properties of its components. The equations of motion of the aircraft as a system carrier (aircraft without a cargo item and wear (of moving a cargo item bodies to reflect the changes in the inertia tensor. The functioning of the power plant, steering actuators, flight control system, an exhaust chute, the sen- sors of the primary information are taken into account. The equations of motion for systems of bodies projected on the air- craft reference plane are being recorded. This approach takes into account changes of the inertia tensor and the position of the main central axes of inertia in the process of landing of a cargo item. It allows us to simulate the condition of the air- craft at all speeds of the pitch, normal overload, and masses of single piece and placement, as evidenced by the high con- vergence of modeling results with data from flight tests.

Standard Test Method for Stress-Corrosion of Titanium Alloys by Aircraft Engine Cleaning Materials

CERN Document Server

American Society for Testing and Materials. Philadelphia

2006-01-01

1.1 This test method establishes a test procedure for determining the propensity of aircraft turbine engine cleaning and maintenance materials for causing stress corrosion cracking of titanium alloy parts. 1.2 The evaluation is conducted on representative titanium alloys by determining the effect of contact with cleaning and maintenance materials on tendency of prestressed titanium alloys to crack when subsequently heated to elevated temperatures. 1.3 Test conditions are based upon manufacturer's maximum recommended operating solution concentration. This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. For specific precautionary statements, see and .

G+K 1Σ+/sub g/ double-minimum excited state of H2

International Nuclear Information System (INIS)

Glover, R.M.; Weinhold, F.

1977-01-01

We have obtained a Born--Oppenheimer potential curve for the previously uncharacterized third 1 Σ + /sub g/ state of H 2 , using a correlated 20-term wavefunction of generalized James--Coolidge type. We find this potential curve to have a double-minimum character, with the inner (Rydberg-like) and outer (''ionic'') wells having minima at about 1.99 and 3.30 bohr, respectively, and an intervening maximum at 2.76 bohr. Unlike the extensively studied E+F double-minimum state, the outer well here appears to be the deeper, by some 450 cm -1 in our calculation. The inner and outer minima can apparently be associated with spectral lines that in experimental tables have previously been attributed to distinct G and K electronic states. The appropriate spectroscopic term symbol of this combined state is accordingly G+K 1 Σ + /sub g/ (1ssigma3dsigma+2pπ 2 )

Atmospheric/climatic effects of aircraft emissions

International Nuclear Information System (INIS)

Pueschel, R.F.

1996-01-01

Exhaust emissions from aircraft include oxides of nitrogen (NO x ), water vapor (H 2 O), sulfur dioxide (SO 2 ), carbon dioxide (CO 2 ), carbon monoxide (CO), hydrocarbons (HC) and particles (soot and sulfates). These emissions are small compared to industrial/urban surface emissions. However, because (1) atmospheric residence times of exhaust constituents are longer at altitude, particularly in the stratosphere, than they are in the boundary layer, (2) their background concentrations at altitude are lower than those near the surface, (3) the radiation balance is the more sensitive to atmospheric trace constituents the colder the temperature aloft and (4) inter-hemispheric mixing of aircraft effluents is inhibited, aircraft emissions near and above the tropopause and polewards of 40 degrees latitude can be environmentally critical. That's why atmospheric/climatic effects of aircraft emissions have again received scientific, economic and political scrutiny in the last few years, motivated by growth of subsonic traffic at about 5% per year over the past two decades and the advent of a technologically feasible operation of a supersonic high speed commercial transport (HSCT) fleet

Response of a Light Aircraft Under Gust Loads

Directory of Open Access Journals (Sweden)

P. Chudý

2004-01-01

Full Text Available This project presents work performed by the Institute of Aerospace Engineering, Brno University of Technology. The primary purpose of this work was to estimate the aeroelastic response of a light aircraft under gust loads. In the past, the gust response has been investigated using the Pratt - Walker formula. This formula is derived from the response of a rigid airplane to a discrete gust. However, the Pratt-Walker formula does not capture either the stochastic nature of continuous turbulence or the effects of structural flexibility. The analysis described here was performed using the advanced FEM software package MSC Nastran.

Longitudinal Static Stability and wake visualization of high altitude long endurance aircraft developed in Bandung institute of technology

Science.gov (United States)

Irsyad Lukman, E.; Agoes Moelyadi, M.

2018-04-01

A High Altitude Long Endurance (HALE) Unamanned Aerial Vehicle (UAV) is currently being researched in Bandung Institute of Technology. The HALE is designed to be a pseudo-sattelite for information and communication purpose in Indonesia. This paper would present the longitudinal static stability of the aircraft that was analysed using DATCOM as well as simulation of the wing using ANSYS CFX. Result shows that the aircraft has acceptable stability and the wake from the wing at climbing condition cannot be ignored, however it does not affect the horizontal tail.

Long Range Aircraft Trajectory Prediction

OpenAIRE

Magister, Tone

2009-01-01

The subject of the paper is the improvement of the aircraft future trajectory prediction accuracy for long-range airborne separation assurance. The strategic planning of safe aircraft flights and effective conflict avoidance tactics demand timely and accurate conflict detection based upon future four–dimensional airborne traffic situation prediction which is as accurate as each aircraft flight trajectory prediction. The improved kinematics model of aircraft relative flight considering flight ...

Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms.

Science.gov (United States)

Sun, Wei; Li, Zirong; Shi, Zhengcai; Wang, Bailiang; Gao, Fuqiang; Yang, Yurun; Guo, Wanshou

2014-05-01

To explore the correlation between post-severe acute respiratory symptom (SARS) patients with osteonecrosis, investigate the etiology of post-SARS osteonecrosis and select the sensitive molecular symbols for early diagnosis and distinguish the high-risk population. The studied subjects were divided into two groups. Sixty-two post-SARS patients with osteonecrosis were one group, and 52 age- and sex-matched healthy people were as normal controlled group. Empty stomach blood samples from cubital veins were collected from both groups. Plasminogen activator inhibitor (PAI) by means of enzyme-linked immunosorbent assay and PAI-1 4G/5G polymorphism was detected by polymerase chain reaction and solid phase oligonucleotide assay. The blood agents of post-SARS patients changed obviously with 15.64 ± 13.85 U/ml while the control group 7.96 ± 4.27 U/ml; 4G/4G genotype for the PAI-1 polymorphism detected in post-SARS group was more than that of the control group, but had no statistical significance. The plasma PAI activity was related to homozygote 4G/4G genotype. This reveals that homozygote 4G/4G genotype may be a susceptible gene mark to Chinese osteonecrosis patients. Plasminogen activator inhibitor-1 is sensitive blood symbol for screening high-risk susceptible population; 4G/4G PAI-1 genotype may be an etiological factor in osteonecrosis.

Human and behavioral factors contributing to spine-based neurological cockpit injuries in pilots of high-performance aircraft: recommendations for management and prevention

Science.gov (United States)

Jones, J. A.; Hart, S. F.; Baskin, D. S.; Effenhauser, R.; Johnson, S. L.; Novas, M. A.; Jennings, R.; Davis, J.

2000-01-01

In high-performance aircraft, the need for total environmental awareness coupled with high-g loading (often with abrupt onset) creates a predilection for cervical spine injury while the pilot is performing routine movements within the cockpit. In this study, the prevalence and severity of cervical spine injury are assessed via a modified cross-sectional survey of pilots of multiple aircraft types (T-38 and F-14, F-16, and F/A-18 fighters). Ninety-five surveys were administered, with 58 full responses. Fifty percent of all pilots reported in-flight or immediate post-flight spine-based pain, and 90% of fighter pilots reported at least one event, most commonly (> 90%) occurring during high-g (> 5 g) turns of the aircraft with the head deviated from the anatomical neutral position. Pre-flight stretching was not associated with a statistically significant reduction in neck pain episodes in this evaluation, whereas a regular weight training program in the F/A-18 group approached a significant reduction (mean = 2.492; p < 0.064). Different cockpit ergonomics may vary the predisposition to cervical injury from airframe to airframe. Several strategies for prevention are possible from both an aircraft design and a preventive medicine standpoint. Countermeasure strategies against spine injury in pilots of high-performance aircraft require additional research, so that future aircraft will not be limited by the human in control.

Modeling flight attendants' exposure to secondhand smoke in commercial aircraft: historical trends from 1955 to 1989.

Science.gov (United States)

Liu, Ruiling; Dix-Cooper, Linda; Hammond, S Katharine

2015-01-01

Flight attendants were exposed to elevated levels of secondhand smoke (SHS) in commercial aircraft when smoking was allowed on planes. During flight attendants' working years, their occupational SHS exposure was influenced by various factors, including the prevalence of active smokers on planes, fliers' smoking behaviors, airplane flight load factors, and ventilation systems. These factors have likely changed over the past six decades and would affect SHS concentrations in commercial aircraft. However, changes in flight attendants' exposure to SHS have not been examined in the literature. This study estimates the magnitude of the changes and the historic trends of flight attendants' SHS exposure in U.S. domestic commercial aircraft by integrating historical changes of contributing factors. Mass balance models were developed and evaluated to estimate flight attendants' exposure to SHS in passenger cabins, as indicated by two commonly used tracers (airborne nicotine and particulate matter (PM)). Monte Carlo simulations integrating historical trends and distributions of influence factors were used to simulate 10,000 flight attendants' exposure to SHS on commercial flights from 1955 to 1989. These models indicate that annual mean SHS PM concentrations to which flight attendants were exposed in passenger cabins steadily decreased from approximately 265 μg/m(3) in 1955 and 1960 to 93 μg/m(3) by 1989, and airborne nicotine exposure among flight attendants also decreased from 11.1 μg/m(3) in 1955 to 6.5 μg/m(3) in 1989. Using duration of employment as an indicator of flight attendants' cumulative occupational exposure to SHS in epidemiological studies would inaccurately assess their lifetime exposures and thus bias the relationship between the exposure and health effects. This historical trend should be considered in future epidemiological studies.

DOE standard: Integration of environment, safety, and health into facility disposition activities. Volume 1 of 2: Technical standard

International Nuclear Information System (INIS)

1998-05-01

This Department of Energy (DOE) technical standard (referred to as the Standard) provides guidance for integrating and enhancing worker, public, and environmental protection during facility disposition activities. It provides environment, safety, and health (ES and H) guidance to supplement the project management requirements and associated guidelines contained within DOE O 430.1A, Life-Cycle Asset Management (LCAM), and amplified within the corresponding implementation guides. In addition, the Standard is designed to support an Integrated Safety Management System (ISMS), consistent with the guiding principles and core functions contained in DOE P 450.4, Safety Management System Policy, and discussed in DOE G 450.4-1, Integrated Safety Management System Guide. The ISMS guiding principles represent the fundamental policies that guide the safe accomplishment of work and include: (1) line management responsibility for safety; (2) clear roles and responsibilities; (3) competence commensurate with responsibilities; (4) balanced priorities; (5) identification of safety standards and requirements; (6) hazard controls tailored to work being performed; and (7) operations authorization. This Standard specifically addresses the implementation of the above ISMS principles four through seven, as applied to facility disposition activities

ARM Cloud-Aerosol-Precipitation Experiment (ACAPEX) Field Campaign Report

Energy Technology Data Exchange (ETDEWEB)

Leung, L Ruby [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2016-03-01

The U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility’s ARM Cloud-Aerosol-Precipitation Experiment (ACAPEX) field campaign contributes to CalWater 2015, a multi-agency field campaign that aims to improve understanding of atmospheric rivers and aerosol sources and transport that influence cloud and precipitation processes. The ultimate goal is to reduce uncertainties in weather predictions and climate projections of droughts and floods in California. With the DOE G-1 aircraft and ARM Mobile Facility 2 (AMF2) well equipped for making aerosol and cloud measurements, ACAPEX focuses specifically on understanding how aerosols from local pollution and long-range transport affect the amount and phase of precipitation associated with atmospheric rivers. ACAPEX took place between January 12, 2015 and March 8, 2015 as part of CalWater 2015, which included four aircraft (DOE G-1, National Oceanic and Atmospheric Administration [NOAA] G-IV and P-3, and National Aeronautics and Space Administration [NASA] ER-2), the NOAA research ship Ron Brown, carrying onboard the AMF2, National Science Foundation (NSF)-sponsored aerosol and precipitation measurements at Bodega Bay, and the California Department of Water Resources extreme precipitation network.

36 CFR 2.17 - Aircraft and air delivery.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Aircraft and air delivery. 2.17 Section 2.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RESOURCE PROTECTION, PUBLIC USE AND RECREATION § 2.17 Aircraft and air delivery. (a) The following are...

Aircraft Control Using Engine Thrust: A History of Learning TOC Real-Time

Science.gov (United States)

Cole, Jennifer H.; Batteas, Frank; Fullerton, Gordon

2006-01-01

A history of learning the operation of Throttles Only Control (TOC) to control an aircraft in real time using engine thrust is shown. The topics include: 1) Past TOC Accidents/Incidents; 2) 1972: DC-10 American Airlines; 3) May 1974: USAF B-52H; 4) April 1975: USAF C-5A; 5) April 1975: USAF C-5A; 6) 1981: USAF B-52G; 7) August 1985: JAL 123 B-747; 8) JAL 123 Survivor Story; 9) JAL 123 Investigation Findings; 10) July 1989: UAL 232 DC-10; 11) UAL 232 DC-10; 12) Eastwind 517 B-737; 13) November 2003: DHL A-300; 14) Historically, TOC has saved lives; 15) Automated Throttles-Only Control; 16) PCA Project; 17) Propulsion-Controlled Aircraft; 18) MD-11 PCA System and Flight Test Envelope; 19) MD-11 Simulation, PCA ILS-Soupled Landing Dispersion; 20) Throttles-Only Pitch and Roll Control Power; 21) PCA in Commercial Fleet; 22) Fall 2005: PCAR Project; 23) PCAR Background - TOC; and 24) PCAR Background - TOC.

Cytometry of chromatin bound Mcm6 and PCNA identifies two states in G1 that are separated functionally by the G1 restriction point1

Directory of Open Access Journals (Sweden)

Jacobberger James W

2010-04-01

Full Text Available Abstract Background Cytometric measurements of DNA content and chromatin-bound Mcm2 have demonstrated bimodal patterns of expression in G1. These patterns, the replication licensing function of Mcm proteins, and a correlation between Mcm loading and cell cycle commitment for cells re-entering the cell cycle, led us to test the idea that cells expressing a defined high level of chromatin-bound Mcm6 in G1 are committed - i.e., past the G1 restriction point. We developed a cell-based assay for tightly-bound PCNA (PCNA* and Mcm6 (Mcm6*, DNA content, and a mitotic marker to clearly define G1, S, G2, and M phases of the cell cycle. hTERT-BJ1, hTERT-RPE-1, and Molt4 cells were extracted with Triton X-100 followed by methanol fixation, stained with antibodies and DAPI, then measured by cytometry. Results Bivariate analysis of cytometric data demonstrated complex patterns with distinct clustering for all combinations of the 4 variables. In G1, cells clustered in two groups characterized by low and high Mcm6* expression. Serum starvation and release experiments showed that residence in the high group was in late G1, just prior to S phase. Kinetic experiments, employing serum withdrawal, and stathmokinetic analysis with aphidicolin, mimosine or nocodazole demonstrated that cells with high levels of Mcm6* cycled with the committed phases of the cell cycle (S, G2, and M. Conclusions A multivariate assay for Mcm6*, PCNA*, DNA content, and a mitotic marker provides analysis capable of estimating the fraction of pre and post-restriction point G1 cells and supports the idea that there are at least two states in G1 defined by levels of chromatin bound Mcm proteins.

40 CFR 87.6 - Aircraft safety.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Aircraft safety. 87.6 Section 87.6... POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES General Provisions § 87.6 Aircraft safety. The provisions of... met within the specified time without creating a safety hazard. ...

Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA Stability.

Science.gov (United States)

Gao, Guangxun; Chen, Liang; Li, Jingxia; Zhang, Dongyun; Fang, Yong; Huang, Haishan; Chen, Xiequn; Huang, Chuanshu

2014-05-15

The cancer chemopreventive property of Chinese herb new isolate isorhapontigenin (ISO) and mechanisms underlying its activity have never been explored. Here we demonstrated that ISO treatment with various concentrations for 3 weeks could dramatically inhibit TPA/EGF-induced cell transformation of Cl41 cells in Soft Agar assay, whereas co-incubation of cells with ISO at the same concentrations could elicit G0/G1 cell-cycle arrest without redundant cytotoxic effects on non-transformed cells. Further studies showed that ISO treatment resulted in cyclin D1 downregulation in dose- and time-dependent manner. Our results indicated that ISO regulated cyclin D1 at transcription level via targeting JNK/C-Jun/AP-1 activation. Moreover, we found that ISO-inhibited JNK/C-Jun/AP-1 activation was mediated by both upregulation of MKP-1 expression through increasing its mRNA stability and deactivating MKK7. Most importantly, MKP-1 knockdown could attenuate ISO-mediated suppression of JNK/C-Jun activation and cyclin D1 expression, as well as G0/G1 cell cycle arrest and cell transformation inhibition, while ectopic expression of FLAG-cyclin D1 T286A mutant also reversed ISO-induced G0/G1 cell-cycle arrest and inhibition of cell transformation. Our results demonstrated that ISO is a promising chemopreventive agent via upregulating mkp-1 mRNA stability, which is distinct from its cancer therapeutic effect with downregulation of XIAP and cyclin D1 expression.

Empirical analysis of the effect of descent flight path angle on primary gaseous emissions of commercial aircraft.

Science.gov (United States)

Turgut, Enis T; Usanmaz, Oznur; Rosen, Marc A

2018-05-01

In this study, the effects of descent flight path angle (between 1.25° and 4.25°) on aircraft gaseous emissions (carbon monoxide, total hydrocarbons and nitrogen oxides) are explored using actual flight data from aircraft flight data recording system and emissions indices from the International Civil Aviation Organization. All emissions parameters are corrected to flight conditions using Boeing Fuel Flow Method2, where the ambient air pressure, temperature and humidity data are obtained from long-term radiosonde data measured close to the arrival airport. The main findings highlight that the higher the flight path angle, the higher the emission indices of CO and HC, whereas the lower the emissions index of NO x and fuel consumption. Furthermore, during a descent, a heavier aircraft tends to emit less CO and HC, and more NO x . For a five-tonne aircraft mass increase, the average change in emissions indices are found to be -4.1% and -5.7% (CO), -5.4% and -8.2% (HC), and +1.1% and +1.6% (NO x ) for high and low flight path angle groups, respectively. The average emissions indices for CO, HC and NO x during descent are calculated to be 24.5, 1.7 and 5.6 g/kg of fuel, whereas the average emissions for descending from 32,000 ft (9.7 km) and 24,000 ft (7.3 km) are calculated to be 7-8 kg (CO), ∼0.5 kg (HC) and ∼3 kg (NO x ). Copyright © 2018 Elsevier Ltd. All rights reserved.

77 FR 38467 - Special Conditions: Gulfstream Aerospace LP (GALP), Model Gulfstream G280 Airplane; Isolation or...

Science.gov (United States)

2012-06-28

... Gulfstream G280 Airplane; Isolation or Aircraft Electronic System Security Protection From Unauthorized... airplane systems and the passenger entertainment services. Applicability As discussed above, these special... Aircraft Electronic System Security Protection from Unauthorized Internal Access. The applicant must ensure...

Expression of bovine herpesvirus 1 glycoproteins gI and gIII in transfected murine cells

International Nuclear Information System (INIS)

Fitzpatrick, D.R.; Zamb, T.; Parker, M.D.; van Drunen Littel-van den Hurk, S.; Babiuk, L.A.; Lawman, M.J.P.

1988-01-01

Genes encoding two of the major glycoproteins of bovine herpesvirus 1 (BHV-1), gI and gIII, were cloned into the eucaryotic expression vectors pRSVcat and pSV2neo and transfected into murine LMTK - cells, and cloned cell lines were established. The relative amounts of gI or gIII expressed from the two vectors were similar. Expression of gI was cell associated and localized predominantly in the perinuclear region, but nuclear and plasma membrane staining was also observed. Expression of gI was additionally associated with cell fusion and the formation of polykaryons and giant cells. Expression of gIII was localized predominantly in the nuclear and plasma membranes. Radioimmunoprecipitation in the presence or absence of tunicamycin revealed that the recombinant glycoproteins were proteolytically processed and glycosylated and had molecular weights similar to those of the forms of gI and gIII expressed in BHV-1 infected bovine cells. However, both recombinant glycoproteins were glycosylated to a lesser extent than were the forms found in BHV-1 infected bovine cells. For gI, a deficiency in N-linked glycosylated of the amino-terminal half of the protein was identified; for gIII, a deficiency in O-linked glycosylation was implicated. The reactivity pattern of a panel of gI- and gIII-specific monoclonal antibodies, including six which recognize conformation-dependent epitopes, was found to be unaffected by the glycosylation differences and was identical for transfected of BHV-1-infected murine cells. Use of the transfected cells as targets in immune-mediated cytotoxicity assays demonstrated the functional recognition of recombinant gI and gIII by murine antibody and cytotoxic T lymphocytes

Crystal Structure of the Conserved Herpes Virus Fusion Regulator Complex gH–gL

Energy Technology Data Exchange (ETDEWEB)

Chowdary, T.; Cairns, T; Atanasiu, D; Cohen, G; Eisenberg, R; Heldwein, E

2010-01-01

Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH-gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH-gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH-gL activates gB for fusion, possibly through direct binding. Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target.

Crystal structure of the conserved herpes virus fusion regulator complex gH-gL

Energy Technology Data Exchange (ETDEWEB)

Chowdary, Tirumala K; Cairns, Tina M; Atanasiu, Doina; Cohen, Gary H; Eisenberg, Roselyn J; Heldwein, Ekaterina E [UPENN; (Tufts-MED)

2010-09-13

Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH-gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH-gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH-gL activates gB for fusion, possibly through direct binding. Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target.

78 FR 37701 - Airworthiness Directives; Pilatus Aircraft Ltd. Airplanes

Science.gov (United States)

2013-06-24

... Airworthiness Directives; Pilatus Aircraft Ltd. Airplanes AGENCY: Federal Aviation Administration (FAA... directive (AD) for Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC- 6/350-H1, PC-6/350-H2... components and the flap actuator could result in loss of control. We are issuing this proposed AD to require...

Estimation of directivity and sound power levels emitted by aircrafts during taxiing, for outdoor noise prediction purpose

NARCIS (Netherlands)

Asensio, C.; Pavón, I.; Ruiz, M.; Pagan Munoz, Raul; Recuero, M.

2007-01-01

Integrated noise model (INM) is the most internationally used software to calculate noise levels near airports. Take off, landing or pass by operations can be modeled by INM, but it does not consider aircrafts taxiing, which, in some cases, can be important to accurately evaluate and reduce

Examining the Relationship Between Passenger Airline Aircraft Maintenance Outsourcing and Aircraft Safety

Science.gov (United States)

Monaghan, Kari L.

The problem addressed was the concern for aircraft safety rates as they relate to the rate of maintenance outsourcing. Data gathered from 14 passenger airlines: AirTran, Alaska, America West, American, Continental, Delta, Frontier, Hawaiian, JetBlue, Midwest, Northwest, Southwest, United, and USAir covered the years 1996 through 2008. A quantitative correlational design, utilizing Pearson's correlation coefficient, and the coefficient of determination were used in the present study to measure the correlation between variables. Elements of passenger airline aircraft maintenance outsourcing and aircraft accidents, incidents, and pilot deviations within domestic passenger airline operations were analyzed, examined, and evaluated. Rates of maintenance outsourcing were analyzed to determine the association with accident, incident, and pilot deviation rates. Maintenance outsourcing rates used in the evaluation were the yearly dollar expenditure of passenger airlines for aircraft maintenance outsourcing as they relate to the total airline aircraft maintenance expenditures. Aircraft accident, incident, and pilot deviation rates used in the evaluation were the yearly number of accidents, incidents, and pilot deviations per miles flown. The Pearson r-values were calculated to measure the linear relationship strength between the variables. There were no statistically significant correlation findings for accidents, r(174)=0.065, p=0.393, and incidents, r(174)=0.020, p=0.793. However, there was a statistically significant correlation for pilot deviation rates, r(174)=0.204, p=0.007 thus indicating a statistically significant correlation between maintenance outsourcing rates and pilot deviation rates. The calculated R square value of 0.042 represents the variance that can be accounted for in aircraft pilot deviation rates by examining the variance in aircraft maintenance outsourcing rates; accordingly, 95.8% of the variance is unexplained. Suggestions for future research include

Evaluation of all-electric secondary power for transport aircraft

Science.gov (United States)

Murray, W. E.; Feiner, L. J.; Flores, R. R.

1992-01-01

This report covers a study by Douglas Aircraft Company (DAC) of electrical power systems for advanced transport aircraft based upon an all-electric design concept. The concept would eliminate distributed hydraulic and pneumatic secondary power systems, and feature an expanded secondary electrical power system redesigned to supply power to the loads customarily supplied by hydraulic or pneumatic power. The initial study was based on an advanced 20-kHz electrical power transmission and distribution system, using a system architecture supplied by NASA-Lewis Research Center for twin-engine aircraft with many advanced power conversion concepts. NASA-LeRC later requested DAC to refocus the study on 400-Hz secondary power distribution. Subsequent work was based on a three-engine MD-11 aircraft, selected by DAC as a baseline system design that would provide data for the comparative cost/benefit analysis. The study concluded that the 20-kHz concept produced many expected benefits, and that the all-electric trijet weight savings on hardware redesign would be 2,304 pounds plus a 2.1-percent fuel reduction and resized for a total weight reduction of 11,000 pounds. Cost reductions for a fleet of 800 aircraft in a 15-year production program were estimated at $76.71 million for RDT&E; $2.74 million per aircrat for production; $9.84 million for nonrecurring expenses; $120,000 per aircraft for product support; and $300,000 per aircraft per year for operating and maintenance costs, giving a present value of $1.914 billion saved or a future value of $10.496 billion saved.

Investigation of Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G promoter polymorphism in Indian venous thrombosis patients: A case-control study.

Science.gov (United States)

Prabhudesai, Aniket; Shetty, Shrimati; Ghosh, Kanjaksha; Kulkarni, Bipin

2017-09-01

The role of PAI-1 4G/5G polymorphism in venous thrombosis has been contradictory. PAI-1 4G/4G genotype is associated with elevated levels of PAI-1 resulting in a hypofibrinolytic state and a higher thrombotic risk. In this study, the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism of PAI-1 gene in Indian patients with different types of venous thrombosis was investigated for its role in development of thrombosis. A total of 87 portal vein thrombosis (PVT), 71 Budd-Chiari syndrome (BCS), 156 cerebral vein thrombosis (CVT), and 163 deep vein thrombosis (DVT) patients were studied alongside 251 healthy controls for the PAI-1 4G/5G polymorphism by allele-specific PCR. Frequency of 4G/4G genotype was higher in all groups in comparison with controls. 4G/4G was associated with PVT risk (OR=2.51, 95% CI=1.29-4.96, P=.0075), BCS risk (OR=5.98, 95% CI=2.68-13.42, P<.0001), and DVT risk (OR=1.75, 95% CI=0.98-3.02, P=.0225). This is the first case-control study from India establishing PAI-1 4G/4G as a strong risk factor for abdominal thrombosis (PVT and BCS). Statistically significant association was not found between 4G/4G genotype and CVT risk. PAI-1 4G/4G is a strong risk factor for venous thrombosis in Indian patients and should be included in laboratory testing panel of thrombophilia. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G

Directory of Open Access Journals (Sweden)

Annichino-Bizzacchi Joyce M.

1998-01-01

Full Text Available Plasminogen activator inhibitor-1 (PAI-1 is an important inhibitor of fibrinolysis, and increased levels of PAI-1 are associated with atheroma and myocardial infarction. A common 4G/5G insertion/deletion polymorphism located in the promoter region of PAI-1 gene has been described associated with PAI-1 activity in plasma levels. Genotyping of this polymorphism is commonly conducted with an allele-specific oligonucleotide melting technique. In the present study, we describe a quick, easy method for genotyping 4G/5G polymorphism in the promoter region of the PAI-1 gene.

Creating a Test-Validated Finite-Element Model of the X-56A Aircraft Structure

Science.gov (United States)

Pak, Chan-Gi; Truong, Samson

2014-01-01

Small modeling errors in a finite-element model will eventually induce errors in the structural flexibility and mass, thus propagating into unpredictable errors in the unsteady aerodynamics and the control law design. One of the primary objectives of the X-56A Multi-Utility Technology Testbed aircraft is the flight demonstration of active flutter suppression and, therefore, in this study, the identification of the primary and secondary modes for the structural model tuning based on the flutter analysis of the X-56A aircraft. The ground-vibration test-validated structural dynamic finite-element model of the X-56A aircraft is created in this study. The structural dynamic finite-element model of the X-56A aircraft is improved using a model-tuning tool. In this study, two different weight configurations of the X-56A aircraft have been improved in a single optimization run. Frequency and the cross-orthogonality (mode shape) matrix were the primary focus for improvement, whereas other properties such as c.g. location, total weight, and off-diagonal terms of the mass orthogonality matrix were used as constraints. The end result was an improved structural dynamic finite-element model configuration for the X-56A aircraft. Improved frequencies and mode shapes in this study increased average flutter speeds of the X-56A aircraft by 7.6% compared to the baseline model.

System for indicating fuel-efficient aircraft altitude

Science.gov (United States)

Gary, B. L. (Inventor)

1984-01-01

A method and apparatus are provided for indicating the altitude at which an aircraft should fly so the W/d ratio (weight of the aircraft divided by the density of air) more closely approaches the optimum W/d for the aircraft. A passive microwave radiometer on the aircraft is directed at different angles with respect to the horizon to determine the air temperature, and therefore the density of the air, at different altitudes. The weight of the aircraft is known. The altitude of the aircraft is changed to fly the aircraft at an altitude at which is W/d ratio more closely approaches the optimum W/d ratio for that aircraft.

77 FR 55770 - Airworthiness Directives; Cessna Aircraft Company Airplanes

Science.gov (United States)

2012-09-11

... aircraft's hydraulic power pack wiring for incorrect installation, and if needed, correct the installation... this AD, whichever occurs first, inspect the hydraulic power pack wiring for correct installation...) Correct the Installation of the Hydraulic Power Pack Wiring (1) Single engine aircraft: If you find...

150 Passenger Commercial Aircraft

Science.gov (United States)

Bucovsky, Adrian; Romli, Fairuz I.; Rupp, Jessica

2002-01-01

It has been projected that the need for a short-range mid-sized, aircraft is increasing. The future strategy to decrease long-haul flights will increase the demand for short-haul flights. Since passengers prefer to meet their destinations quickly, airlines will increase the frequency of flights, which will reduce the passenger load on the aircraft. If a point-to-point flight is not possible, passengers will prefer only a one-stop short connecting flight to their final destination. A 150-passenger aircraft is an ideal vehicle for these situations. It is mid-sized aircraft and has a range of 3000 nautical miles. This type of aircraft would market U.S. domestic flights or inter-European flight routes. The objective of the design of the 150-passenger aircraft is to minimize fuel consumption. The configuration of the aircraft must be optimized. This aircraft must meet CO2 and NOx emissions standards with minimal acquisition price and operating costs. This report contains all the work that has been performed for the completion of the design of a 150 passenger commercial aircraft. The methodology used is the Technology Identification, Evaluation, and Selection (TIES) developed at Georgia Tech Aerospace Systems Design laboratory (ASDL). This is an eight-step conceptual design process to evaluate the probability of meeting the design constraints. This methodology also allows for the evaluation of new technologies to be implemented into the design. The TIES process begins with defining the problem with a need established and a market targeted. With the customer requirements set and the target values established, a baseline concept is created. Next, the design space is explored to determine the feasibility and viability of the baseline aircraft configuration. If the design is neither feasible nor viable, new technologies can be implemented to open up the feasible design space and allow for a plausible solution. After the new technologies are identified, they must be evaluated

Does exposure to aircraft noise increase the mortality from cardiovascular disease in the population living in the vicinity of airports? Results of an ecological study in France

Directory of Open Access Journals (Sweden)

Anne-Sophie Evrard

2015-01-01

Full Text Available The impact of aircraft noise on health is of growing concern. We investigated the relationship between this exposure and mortality from cardiovascular disease, coronary heart disease, myocardial infarction, and stroke. We performed an ecological study on 161 communes (commune being the smallest administrative unit in France close to the following three major French airports: Paris-Charles de Gaulle, Lyon Saint-Exupéry, and Toulouse-Blagnac. The mortality data were provided by the French Center on Medical Causes of Death for the period 2007-2010. Based on the data provided by the French Civil Aviation Authority, a weighted average exposure to aircraft noise (L den AEI was computed at the commune level. A Poisson regression model with commune-specific random intercepts, adjusted for potential confounding factors including air pollution, was used to investigate the association between mortality rates and L den AEI. Positive associations were observed between L den AEI and mortality from cardiovascular disease [adjusted mortality rate ratio (MRR per 10 dB(A increase in L den AEI = 1.18; 95% confidence interval (CI: 1.11-1.25], coronary heart disease [MRR = 1.24 (1.12-1.36], and myocardial infarction [MRR = 1.28 (1.11-1.46]. Stroke mortality was more weakly associated with L den AEI [MRR = 1.08 (0.97-1.21]. These significant associations were not attenuated after the adjustment for air pollution. The present ecological study supports the hypothesis of an association between aircraft noise exposure and mortality from cardiovascular disease, coronary heart disease, and myocardial infarction. However, the potential for ecological bias and the possibility that this association could be due to residual confounding cannot be excluded.

A Precision Measurement of the Spin Structure Functions f^p_1 and g^g_1

Energy Technology Data Exchange (ETDEWEB)

Toole, T.

2004-12-13

In Experiment E155 at the Stanford Linear Accelerator Center, the spin dependent structure function g{sub 1}(x,Q{sup 2}) was measured for both the proton and deuteron. This was accomplished by scattering 48.3 GeV highly polarized electrons (0.813 {+-} 0.020) off polarized {sup 15}NH{sub 3} (proton) and {sup 6}LiD (deuteron) targets. Data were collected in March and April of 1997 using three fixed angle, momentum analyzing spectrometers centered at 2.75{sup o}, 5.5{sup o}, and 10.5{sup o}. This enabled a kinematic coverage of 0.01 < x < 0.9 and 1 GeV{sup 2} < Q{sup 2} < 40 GeV{sup 2}. At an average Q{sup 2} of 5 GeV{sup 2}, the integrals in the measured region were f{sub 0.014}{sup 0.9}g{sub 1}(x)dx = 0.119 {+-} 0.002(stat.) {+-} 0.009(syst.) for the proton and 0.043 {+-} 0.003(stat.) {+-} 0.003(syst.) for the deuteron. Using a perturbative QCD analysis which included a global data set, the results were found to be consistent with the Bjorken Sum Rule. Asymmetry measurements also were made using photoproduced hadrons. Data were collected concurrently with the g{sub 1} data. For the proton, the asymmetries were small and non-zero. The deuteron measurements were consistent with zero.

Plasminogen activator inhibitor-1 4G/5G polymorphism in infertile women with and without endometriosis.

Science.gov (United States)

Gonçalves-Filho, Rubens P; Brandes, Ariel; Christofolini, Denise M; Lerner, Tatiana G; Bianco, Bianca; Barbosa, Caio P

2011-05-01

To evaluate PAI-1 genotypes in a group of infertile women with or without endometriosis and control subjects. Case-control study. Human Reproduction Center of Medicina do ABC Faculty. One hundred and forty infertile women with endometriosis, 64 women with idiopathic infertility and 148 fertile women as control subjects. The PAI-1 4G/5G polymorphism was identified by restriction fragment length polymorphism-polymerase chain reaction. Genotype distribution and allele frequency of the 4G/5G polymorphism of the PAI-1 gene. The frequencies of genotypes 4G/4G, 4G/5G and 5G/5G of the PAI-1 gene in the infertile women with endometriosis were 38.6, 37.1 and 24.3%, respectively, and in the control group 24.3, 33.8 and 41.9%, respectively (p=0.003). When the infertile women with endometriosis were divided according to their endometriosis stage, genotypes 4G/4G, 4G/5G and 5G/5G were identified, respectively, in 36.7, 32.9 and 30.4% of the patients with minimal/mild endometriosis (p=0.102) and in 41.0, 42.6 and 16.4% of the patients with moderate/severe endometriosis (p=0.001); in the women with idiopathic infertility, these genotypes were found at a frequency of 29.7, 34.3 and 36%, respectively (p=0.637). The data suggest that, in Brazilian women, the PAI-1 4G/5G polymorphism may be associated with a risk of endometriosis-associated infertility. © 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.

Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling.

Science.gov (United States)

Kishore, Ayush; Hall, Randy A

2017-06-09

Mutations to the adhesion G protein-coupled receptor ADGRG1 (G1; also known as GPR56) underlie the neurological disorder bilateral frontoparietal polymicrogyria. Disease-associated mutations in G1 studied to date are believed to induce complete loss of receptor function through disruption of either receptor trafficking or signaling activity. Given that N-terminal truncation of G1 and other adhesion G protein-coupled receptors has been shown to significantly increase the receptors' constitutive signaling, we examined two different bilateral frontoparietal polymicrogyria-inducing extracellular loop mutations (R565W and L640R) in the context of both full-length and N-terminally truncated (ΔNT) G1. Interestingly, we found that these mutations reduced surface expression of full-length G1 but not G1-ΔNT in HEK-293 cells. Moreover, the mutations ablated receptor-mediated activation of serum response factor luciferase, a classic measure of Gα 12/13 -mediated signaling, but had no effect on G1-mediated signaling to nuclear factor of activated T cells (NFAT) luciferase. Given these differential signaling results, we sought to further elucidate the pathway by which G1 can activate NFAT luciferase. We found no evidence that ΔNT activation of NFAT is dependent on Gα q/11 -mediated or β-arrestin-mediated signaling but rather involves liberation of Gβγ subunits and activation of calcium channels. These findings reveal that disease-associated mutations to the extracellular loops of G1 differentially alter receptor trafficking, depending on the presence of the N terminus, and differentially alter signaling to distinct downstream pathways. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

75 FR 52250 - Airworthiness Directives; Aircraft Industries a.s. (Type Certificate G24EU Previously Held by...

Science.gov (United States)

2010-08-25

... wing failed near the root due to positive load. The right wing detached from the aircraft and the...[Iacute]K sailplane, in which the main spar of the right wing failed near the root due to positive load... substance. But we might have found it necessary to use different words from those in the MCAI to ensure the...

The association between PAI-1 -675 4G/5G polymorphism and type 2 diabetes mellitus.

Science.gov (United States)

Chen, L; Li, S-Y; Liu, M

2017-08-15

In this study, we aimed to analyze the association between plasminogen activator inhibitor 1 (PAI-1) -675 4G/5G polymorphism and type 2 diabetes mellitus (T2DM) risk. We included in 187 T2DM patients and 186 heathy controls between 2014 and 2017 from Tianjin Gong An Hospital, China. All patients and controls were ethnically Chinese Han population. The primers and polymerase chain reaction (PCR) conditions were performed. Results from this case-control study suggested that PAI-1 -675 4G/5G polymorphism was not associated with T2DM risk in four genetic models. Additionally, PAI-1 -675 4G/5G polymorphism was not associated with clinical and laboratory characteristics, such as age, gender, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, and HbA1c. In conclusion, this case-control study suggested that PAI-1 -675 4G/5G polymorphism was not associated with T2DM risk in this population.

A fuel cell driven aircraft baggage tractor

Energy Technology Data Exchange (ETDEWEB)

Sterkenburg, Stefan van [HAN Univ. of Applied Sciences (Netherlands); Rijs, Aart van; Hupkens, Huib [Silent Motor Company, Arnhem (Netherlands)

2010-07-01

Silent Motor Company and the HAN University of Applied Science collaborate in the development of an aircraft baggage tractor. The baggage tractor is equipped with an 8kW fuel cell stack connected to a 26kWh battery-pack. The control system implemented minimizes the start-up time of the fuel cell system, protects the fuel cell against overload and underload and controls the State of Charge (SOC) of the battery to its optimum value. A practical SOC-determination method is implemented which does not need detailed knowledge about the batteries applied. This paper presents a description of the fuel cell system, its energy management system and SOC-determination method and the results of first test measurements. (orig.)

Novel matrix resins for composites for aircraft primary structures, phase 1

Science.gov (United States)

Woo, Edmund P.; Puckett, P. M.; Maynard, S.; Bishop, M. T.; Bruza, K. J.; Godschalx, J. P.; Mullins, M. J.

1992-01-01

The objective of the contract is the development of matrix resins with improved processability and properties for composites for primarily aircraft structures. To this end, several resins/systems were identified for subsonic and supersonic applications. For subsonic aircraft, a series of epoxy resins suitable for RTM and powder prepreg was shown to give composites with about 40 ksi compressive strength after impact (CAI) and 200 F/wet mechanical performance. For supersonic applications, a thermoplastic toughened cyanate prepreg system has demonstrated excellent resistance to heat aging at 360 F for 4000 hours, 40 ksi CAI and useful mechanical properties at greater than or equal to 310 F. An AB-BCB-maleimide resin was identified as a leading candidate for the HSCT. Composite panels fabricated by RTM show CAI of approximately 50 ksi, 350 F/wet performance and excellent retention of mechanical properties after aging at 400 F for 4000 hours.

PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis.

Science.gov (United States)

Xu, Xin; Xie, Yanqi; Lin, Yiwei; Xu, Xianglai; Zhu, Yi; Mao, Yeqing; Hu, Zhenghui; Wu, Jian; Chen, Hong; Zheng, Xiangyi; Qin, Jie; Xie, Liping

2012-12-01

Plasminogen activator inhibitor-1 (PAI-1), belonging to the urokinase plasminogen activation (uPA) system, is involved in cancer development and progression. The PAI-1 promoter 4G/5G polymorphism was shown to contribute to genetic susceptibility to cancer, although the results were inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The electronic databases PubMed, Scopus, Web of Science and Chinese National Knowledge Infrastructure (CNKI) were searched; data were extracted and analyzed independently by two reviewers. Ultimately, 21 eligible case-control studies with a total of 8,415 cancer cases and 9,208 controls were included. The overall odds ratio (OR) with its 95% confidence interval (CI) showed a statistically significant association between the PAI-1 promoter 4G/5G polymorphism and cancer risk (4G/4G vs. 5G/5G: OR=1.25, 95% CI=1.07-1.47, P(heterogeneity)=0.001; 4G/4G vs. 4G/5G+5G/5G: OR=1.10, 95% CI=1.03-1.17, P(heterogeneity)=0.194; 4G/4G+4G/5G vs. 5G/5G: OR=1.17, 95% CI=1.01-1.35, P(heterogeneity)=0.041). In further subgroup analyses, the increased risk of cancer was observed in a subgroup of Caucasians with regards to endometrial cancer. Our meta-analysis suggests that the PAI-1 4G/5G polymorphism most likely contributes to susceptibility to cancer, particularly in Caucasians. Furthermore, the 4G allele may be associated with an increased risk of endometrial cancer.

In-flight dose estimates for aircraft crew and pregnant female crew members in military transport missions

International Nuclear Information System (INIS)

Alves, J. G.; Mairos, J. C.

2007-01-01

Aircraft fighter pilots may experience risks other than the exposure to cosmic radiation due to the characteristics of a typical fighter flight. The combined risks for fighter pilots due to the G-forces, hypobaric hypoxia, cosmic radiation exposure, etc. have determined that pregnant female pilots should remain on ground. However, several military transport missions can be considered an ordinary civil aircraft flight and the question arises whether a pregnant female crew member could still be part of the aircraft crew. The cosmic radiation dose received was estimated for transport missions carried out on the Hercules C-130 type of aircraft by a single air squad in 1 month. The flights departed from Lisboa to areas such as: the Azores, several countries in central and southern Africa, the eastern coast of the USA and the Balkans, and an estimate of the cosmic radiation dose received on each flight was carried out. A monthly average cosmic radiation dose to the aircraft crew was determined and the dose values obtained were discussed in relation to the limits established by the European Union Council Directive 96/29/Euratom. The cosmic radiation dose estimates were performed using the EPCARD v3.2 and the CARI-6 computing codes. EPCARD v3.2 was kindly made available by GSF-National Research Centre for Environment and Health, Inst. of Radiation Protection (Neuherberg (Germany)). CARI-6 (version July 7, 2004) was downloaded from the web site of the Civil Aerospace Medical Inst., Federal Aviation Administration (USA). In this study an estimate of the cosmic radiation dose received by military aircraft crew on typical transport missions is made. (authors)

Recent Observational Efforts Using the DOE ARM Observatory at Oliktok Point, Alaska

Science.gov (United States)

de Boer, G.; Shupe, M.; McComiskey, A. C.; Creamean, J.; Williams, C. R.; Matrosov, S. Y.; Solomon, A.; Turner, D. D.; Norgren, M.; Maahn, M.; Lawrence, D.; Argrow, B. M.; Palo, S. E.; Weibel, D.; Curry, N.; Nichols, T.; D'Amore, P.; Finamore, W.; Ivey, M.; Bendure, A.; Schmid, B.; Biraud, S.

2016-12-01

The US Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) program has deployed it's third mobile facility (AMF-3) to Oliktok Point, Alaska for an extended measurement campaign. This facility includes a variety of instruments to measure clouds, aerosols, surface meteorology, and surface energy exchange (including radiation). Additionally, this site features two areas of controlled airspace in which additional measurements can be made using manned- and unmanned aircraft and tethered balloons. Over the past two years, several field campaigns have taken place to make measurements complimentary to those collected by the AMF-3. These include several unmanned aircraft and tethered balloon campaigns (Coordinated Observations of the Lower Arctic Atmosphere, COALA; Evaluation of Routine Atmospheric Sounding Measurements using Unmanned Systems, ERASMUS; Inaugural Campaigns for ARM Research using Unmanned Systems, ICARUS), as well as a manned aircraft campaign during the summer of 2015 (ARM Carbon Measurement Experiment, ACME-5). In addition to these field campaigns, DOE has formed a site science team to conduct research using AMF-3 measurements. In this presentation, we will provide an overview of these measurement campaigns. Additionally, we will provide an overview of scientific results from these campaigns and from AMF-3 research that aid to inform numerical modeling efforts.

Fettered aircraft for using wind energy

Energy Technology Data Exchange (ETDEWEB)

Hoeppner, H.; Horvath, E.; Ulrich, S.

1980-08-28

The invention concerns an aircraft tethered by cables, whose balloon-shaped central body produces static and aerodynamic upthrust and which carries turbines, which are used to convert wind energy and to drive the aircraft. The purpose of the invention is to provide an aircraft, which will keep wind energy plant at the optimum height. A new type of aircraft is used to solve the problem, which, according to the invention, combines static upthrust, the production of aerodynamic upthrust, wind energy conversion, energy transport and forward drive in a technically integrated aircraft. If the use of windpower is interrupted, then if necessary the drive together with a remote control system provides controlled free flight of the aircraft. One variant of the object of the invention consists of a central, balloon-shaped body for upthrust, in which there are wind turbines driving electrical generators. According to the invention the motors required to start the wind turbines are of such dimensions that they will drive the turbines in free flight of the aircraft and thus provide forward drive of the aircraft. A power generating unit, consisting of an internal combustion engine and the starter motors switched over to generator operation is used to provide house service supplies for control and regulation of the aircraft.

G-CSF prevents caspase 3 activation in Schwann cells after sciatic nerve transection, but does not improve nerve regeneration.

Science.gov (United States)

Frost, Hanna K; Kodama, Akira; Ekström, Per; Dahlin, Lars B

2016-10-15

Exogenous granulocyte-colony stimulating factor (G-CSF) has emerged as a drug candidate for improving the outcome after peripheral nerve injuries. We raised the question if exogenous G-CSF can improve nerve regeneration following a clinically relevant model - nerve transection and repair - in healthy and diabetic rats. In short-term experiments, distance of axonal regeneration and extent of injury-induced Schwann cell death was quantified by staining for neurofilaments and cleaved caspase 3, respectively, seven days after repair. There was no difference in axonal outgrowth between G-CSF-treated and non-treated rats, regardless if healthy Wistar or diabetic Goto-Kakizaki (GK) rats were examined. However, G-CSF treatment caused a significant 13% decrease of cleaved caspase 3-positive Schwann cells at the lesion site in healthy rats, but only a trend in diabetic rats. In the distal nerve segments of healthy rats a similar trend was observed. In long-term experiments of healthy rats, regeneration outcome was evaluated at 90days after repair by presence of neurofilaments, wet weight of gastrocnemius muscle, and perception of touch (von Frey monofilament testing weekly). The presence of neurofilaments distal to the suture line was similar in G-CSF-treated and non-treated rats. The weight ratio of ipsi-over contralateral gastrocnemius muscles, and perception of touch at any time point, were likewise not affected by G-CSF treatment. In addition, the inflammatory response in short- and long-term experiments was studied by analyzing ED1 stainable macrophages in healthy rats, but in neither case was any attenuation seen at the injury site or distal to it. G-CSF can prevent caspase 3 activation in Schwann cells in the short-term, but does not detectably affect the inflammatory response, nor improve early or late axonal outgrowth or functional recovery. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

Fuel containment and damage tolerance for large composite primary aircraft structures. Phase 1: Testing

Science.gov (United States)

Sandifer, J. P.

1983-01-01

Technical problems associated with fuel containment and damage tolerance of composite material wings for transport aircraft were identified. The major tasks are the following: (1) the preliminary design of damage tolerant wing surface using composite materials; (2) the evaluation of fuel sealing and lightning protection methods for a composite material wing; and (3) an experimental investigation of the damage tolerant characteristics of toughened resin graphite/epoxy materials. The test results, the test techniques, and the test data are presented.

Wind Information Uplink to Aircraft Performing Interval Management Operations

Science.gov (United States)

Ahmad, Nashat N.; Barmore, Bryan E.; Swieringa, Kurt A.

2016-01-01

Interval Management (IM) is an ADS-B-enabled suite of applications that use ground and flight deck capabilities and procedures designed to support the relative spacing of aircraft (Barmore et al., 2004, Murdoch et al. 2009, Barmore 2009, Swieringa et al. 2011; Weitz et al. 2012). Relative spacing refers to managing the position of one aircraft to a time or distance relative to another aircraft, as opposed to a static reference point such as a point over the ground or clock time. This results in improved inter-aircraft spacing precision and is expected to allow aircraft to be spaced closer to the applicable separation standard than current operations. Consequently, if the reduced spacing is used in scheduling, IM can reduce the time interval between the first and last aircraft in an overall arrival flow, resulting in increased throughput. Because IM relies on speed changes to achieve precise spacing, it can reduce costly, low-altitude, vectoring, which increases both efficiency and throughput in capacity-constrained airspace without negatively impacting controller workload and task complexity. This is expected to increase overall system efficiency. The Flight Deck Interval Management (FIM) equipment provides speeds to the flight crew that will deliver them to the achieve-by point at the controller-specified time, i.e., assigned spacing goal, after the target aircraft crosses the achieve-by point (Figure 1.1). Since the IM and target aircraft may not be on the same arrival procedure, the FIM equipment predicts the estimated times of arrival (ETA) for both the IM and target aircraft to the achieve-by point. This involves generating an approximate four-dimensional trajectory for each aircraft. The accuracy of the wind data used to generate those trajectories is critical to the success of the IM operation. There are two main forms of uncertainty in the wind information used by the FIM equipment. The first is the accuracy of the forecast modeling done by the weather

Aircraft Capability Management

Science.gov (United States)

Mumaw, Randy; Feary, Mike

2018-01-01

This presentation presents an overview of work performed at NASA Ames Research Center in 2017. The work concerns the analysis of current aircraft system management displays, and the initial development of an interface for providing information about aircraft system status. The new interface proposes a shift away from current aircraft system alerting interfaces that report the status of physical components, and towards displaying the implications of degradations on mission capability. The proposed interface describes these component failures in terms of operational consequences of aircraft system degradations. The research activity was an effort to examine the utility of different representations of complex systems and operating environments to support real-time decision making of off-nominal situations. A specific focus was to develop representations that provide better integrated information to allow pilots to more easily reason about the operational consequences of the off-nominal situations. The work is also seen as a pathway to autonomy, as information is integrated and understood in a form that automated responses could be developed for the off-nominal situations in the future.

PAI-1 4G/5G polymorphism and plasma levels association in patients with coronary artery disease.

Science.gov (United States)

Lima, Luciana Moreira; Carvalho, Maria das Graças; Fonseca Neto, Cirilo Pereira; Garcia, José Carlos Faria; Sousa, Marinez Oliveira

2011-12-01

Type-1 plasminogen activator inhibitor (PAI-1) 4G/5G polymorphism may influence the PAI-1 expression. High plasma levels of PAI-1 are associated with coronary artery disease (CAD). This study investigated the influence of PAI-1 4G/5G polymorphism on plasma PAI-1 levels and its association with CAD assessed by coronary angiography. Blood sample of 35 individuals with angiographically normal coronary arteries, 31 individuals presenting mild/moderate atheromatosis, 57 individuals presenting severe atheromatosis and 38 healthy individuals (controls) were evaluated. In patients and controls, the PAI-1 4G/5G polymorphism was determined by PCR amplification using allele-specific primers. Plasma PAI-1 levels were quantified by ELISA assay (American Diagnostica). No difference was found between groups regarding age, gender and body mass index. Plasma PAI-1 levels and 4G/4G genotype frequency were significantly higher in the severe atheromatosis group compared to the other groups (p5G/5G genotype (r=0.02, p=0.4511). In addition, in a multiple logistic regression model, adjusted for all the other variables, PAI-1 was observed to be independently associated with CAD > 70% (p<0.001). The most important finding of this study was the association between 4G/4G genotype, high plasma PAI-1 levels and coronary stenosis higher than 70% in Brazilian individuals. Whether high plasma PAI-1 levels are a decisive factor for atherosclerosis worsening or it is a consequence remains to be established.

Enhancing Combat Survivability of Existing Unmanned Aircraft Systems

Science.gov (United States)

2008-12-01

1 With efforts underway to develop rules integrating UAS’s into the National Airspace System, and...realizing that Federal Aviation Administration rule -making authority applied only to "aircraft," the term Remotely Operated Aircraft (ROA) was coined in...http://www.af.mil/factsheets/factsheet.asp?id=122 [10] Peter La Franchi , “US study recommends self-protection for UAVs”, Flight International, 7

Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis

Directory of Open Access Journals (Sweden)

Zhang Tengyue

2013-01-01

Full Text Available Abstract Background Mounting evidence has suggested that plasminogen activator inhibitor-1 (PAI-1 is a candidate for increased risk of diabetic retinopathy. Studies have reported that insertion/deletion polymorphism in the PAI-1 gene may influence the risk of this disease. To comprehensively address this issue, we performed a meta-analysis to evaluate the association of PAI-1 4G/5G polymorphism with diabetic retinopathy in type 2 diabetes. Methods Data were retrieved in a systematic manner and analyzed using Review Manager and STATA Statistical Software. Crude odds ratios (ORs with 95% confidence intervals (CIs were used to assess the strength of associations. Results Nine studies with 1, 217 cases and 1, 459 controls were included. Allelic and genotypic comparisons between cases and controls were evaluated. Overall analysis suggests a marginal association of the 4G/5G polymorphism with diabetic retinopathy (for 4G versus 5G: OR 1.13, 95%CI 1.01 to 1.26; for 4G/4G versus 5G/5G: OR 1.30, 95%CI 1.04 to 1.64; for 4G/4G versus 5G/5G + 4G/5G: OR 1.26, 95%CI 1.05 to 1.52. In subgroup analysis by ethnicity, we found an association among the Caucasian population (for 4G versus 5G: OR 1.14, 95% CI 1.00 to 1.30; for 4G/4G versus 5G/5G: OR 1.33, 95%CI 1.02 to 1.74; for 4G/4G versus 5G/5G + 4G/5G: OR 1.41, 95%CI 1.13 to 1.77. When stratified by the average duration of diabetes, patients with diabetes histories longer than 10 years have an elevated susceptibility to diabetic retinopathy than those with shorter histories (for 4G/4G versus 5G/5G: OR 1.47, 95%CI 1.08 to 2.00. We also detected a higher risk in hospital-based studies (for 4G/4G versus 5G/5G+4G/5G: OR 1.27, 95%CI 1.02 to 1.57. Conclusions The present meta-analysis suggested that 4G/5G polymorphism in the PAI-1 gene potentially increased the risk of diabetic retinopathy in type 2 diabetes and showed a discrepancy in different ethnicities. A higher susceptibility in patients with longer duration of

Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis.

Science.gov (United States)

Zhang, Tengyue; Pang, Chong; Li, Ningdong; Zhou, Elaine; Zhao, Kanxing

2013-01-02

Mounting evidence has suggested that plasminogen activator inhibitor-1 (PAI-1) is a candidate for increased risk of diabetic retinopathy. Studies have reported that insertion/deletion polymorphism in the PAI-1 gene may influence the risk of this disease. To comprehensively address this issue, we performed a meta-analysis to evaluate the association of PAI-1 4G/5G polymorphism with diabetic retinopathy in type 2 diabetes. Data were retrieved in a systematic manner and analyzed using Review Manager and STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Nine studies with 1, 217 cases and 1, 459 controls were included. Allelic and genotypic comparisons between cases and controls were evaluated. Overall analysis suggests a marginal association of the 4G/5G polymorphism with diabetic retinopathy (for 4G versus 5G: OR 1.13, 95%CI 1.01 to 1.26; for 4G/4G versus 5G/5G: OR 1.30, 95%CI 1.04 to 1.64; for 4G/4G versus 5G/5G + 4G/5G: OR 1.26, 95%CI 1.05 to 1.52). In subgroup analysis by ethnicity, we found an association among the Caucasian population (for 4G versus 5G: OR 1.14, 95% CI 1.00 to 1.30; for 4G/4G versus 5G/5G: OR 1.33, 95%CI 1.02 to 1.74; for 4G/4G versus 5G/5G + 4G/5G: OR 1.41, 95%CI 1.13 to 1.77). When stratified by the average duration of diabetes, patients with diabetes histories longer than 10 years have an elevated susceptibility to diabetic retinopathy than those with shorter histories (for 4G/4G versus 5G/5G: OR 1.47, 95%CI 1.08 to 2.00). We also detected a higher risk in hospital-based studies (for 4G/4G versus 5G/5G+4G/5G: OR 1.27, 95%CI 1.02 to 1.57). The present meta-analysis suggested that 4G/5G polymorphism in the PAI-1 gene potentially increased the risk of diabetic retinopathy in type 2 diabetes and showed a discrepancy in different ethnicities. A higher susceptibility in patients with longer duration of diabetes (more than 10 years) indicated a gene

What makes a space invader? Passenger perceptions of personal space invasion in aircraft travel.

Science.gov (United States)

Lewis, Laura; Patel, Harshada; D'Cruz, Mirabelle; Cobb, Sue

2017-11-01

The invasion of personal space is often a contributory factor to the experience of discomfort in aircraft passengers. This paper presents a questionnaire study which investigated how air travellers are affected by invasions of personal space and how they attempt to adapt to, or counter, these invasions. In support of recent findings on the factors influencing air passenger comfort, the results of this study indicate that the invasion of personal space is not only caused by physical factors (e.g. physical contact with humans or objects), but also other sensory factors such as noise, smells or unwanted eye contact. The findings of this study have implications for the design of shared spaces. Practitioner Summary: This paper presents a questionnaire study which investigated personal space in an aircraft environment. The results highlight the factors which affect the perception of personal space invasion in aircraft and can therefore inform the design of aircraft cabin environments to enhance the passenger experience.

40 CFR 220.1 - Purpose and scope.

Science.gov (United States)

2010-07-01

...) In the case of a vessel or aircraft registered in the United States or flying the United States flag... requirements of the Act. (c) Exclusions—(1) Fish wastes. This subchapter H does not apply to, and no permit... waters of fish wastes unless such dumping occurs in: (i) Harbors or other protected or enclosed coastal...

Essentials of aircraft armaments

CERN Document Server

Kaushik, Mrinal

2017-01-01

This book aims to provide a complete exposure about armaments from their design to launch from the combat aircraft. The book details modern ammunition and their tactical roles in warfare. The proposed book discusses aerodynamics, propulsion, structural as well as navigation, control, and guidance of aircraft armament. It also introduces the various types of ammunition developed by different countries and their changing trends. The book imparts knowledge in the field of design, and development of aircraft armaments to aerospace engineers and covers the role of the United Nations in peacekeeping and disarmament. The book will be very useful to researchers, students, and professionals working in design and manufacturing of aircraft armaments. The book will also serve air force and naval aspirants, and those interested in working on defence research and developments organizations. .

75 FR 39795 - Airworthiness Directives; Aircraft Industries a.s. (Type Certificate G60EU Previously Held by...

Science.gov (United States)

2010-07-13

... failed near the root due to positive load. The right wing detached from the aircraft and the pilots lost... spar of the right wing failed near the root due to positive load. The right wing detached from the... have found it necessary to use different words from those in the MCAI to ensure the AD is clear for U.S...

An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

OpenAIRE

Cheetham, B F

1983-01-01

Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation.

Aircraft operability methods applied to space launch vehicles

Science.gov (United States)

Young, Douglas

1997-01-01

The commercial space launch market requirement for low vehicle operations costs necessitates the application of methods and technologies developed and proven for complex aircraft systems. The ``building in'' of reliability and maintainability, which is applied extensively in the aircraft industry, has yet to be applied to the maximum extent possible on launch vehicles. Use of vehicle system and structural health monitoring, automated ground systems and diagnostic design methods derived from aircraft applications support the goal of achieving low cost launch vehicle operations. Transforming these operability techniques to space applications where diagnostic effectiveness has significantly different metrics is critical to the success of future launch systems. These concepts will be discussed with reference to broad launch vehicle applicability. Lessons learned and techniques used in the adaptation of these methods will be outlined drawing from recent aircraft programs and implementation on phase 1 of the X-33/RLV technology development program.

Optimization of chromatographic conditions for determination of aflatoxin B1, B2, G1 and G2 by using liquid chromatography-mass Spectrometry

Science.gov (United States)

Ramadhaningtyas, Dillani Putri; Aryana, Nurhani; Aristiawan, Yosi; Styarini, Dyah

2017-11-01

The optimization of instrument condition and chromatographic separation for analysis of aflatoxin B1, B2, G1 and G2 using liquid chromatography tandem with mass spectrometer detector was conducted in the aim to provide more accurate and reliable analysis results. The aflatoxin known to be serious threat for human health as it is classified as the carcinogenic compounds. The aflatoxin B1, B2, G1 and G2 were selected due to its extensive contamination in various agricultural commodities. The best chromatographic separation was obtained using C-18 column with gradient elution of solvent 5 mM ammonium acetate and 0.1% formic acid in methanol at 7 minutes runtime analysis. The linearity of the detector showed satisfied results as the coefficient determination found to be 0.9994, 0.9996, 0.9998 and 0.9987 for aflatoxin B1, G1, B2, and G2 respectively in the range concentration from 1 to 20 ng/g. The quantifier ion selected for the aflatoxin B1, B2, G1 and G2 was m/z 285.1, 259, 243 and 313 respectively. The instrument precision at these quantifier ions also showed satisfied result with %RSD was around 3.4 to 6.8%. The optimized method present in this study can be used for further sample analysis.

Plasminogen activator inhibitor-1 4G/5G polymorphism is associated with type 2 diabetes risk

Science.gov (United States)

Zhao, Luqian; Huang, Ping

2013-01-01

A number of studies were performed to assess the association between plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and susceptibility to type 2 diabetes (T2DM). However, the results were inconsistent and inconclusive. In the present study, the possible association was investigated by a meta-analysis. Eligible articles were identified for the period up to June 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from random-effects models or fixed-effects models. Fourteen case-control studies with a total of 2487 cases and 3538 controls were eligible. In recessive model, PAI-1 4G/5G polymorphism was associated with T2DM risk (OR = 1.23; 95% CI 1.07-1.41; P = 0.004). In the subgroup analysis by ethnicity, a significant association was found among Asians (OR = 1.27; 95% CI 1.08-1.51; P = 0.005). This meta-analysis suggested that PAI-1 4G/5G polymorphism may be associated with T2DM development. PMID:24040470

Indexing, screening, coding and cataloging of earth resources aircraft mission data

Science.gov (United States)

1977-01-01

Tasks completed are as follows: (1) preparation of large Area Crop Inventory experiment for data base entry;(2) preparation of Earth Observations Aircraft Flight summary reports for publication; (3) updating of the aircraft mission index coverage map and Ames aircraft flight map; (4) Prepared of Earth Observation Helicopter Flight reports for publication; and (5) indexing of LANDSAT imagery. (6) formulation of phase 3 biowindows 1, 2, 3, and 4 listings by country, footprint, and acqusition dates; (7) preparation of flight summary reports; and (8) preparation of an Alaska state index coverage map.

Derivation of residual radioactive material guidelines for uranium in soil at the Former Associate Aircraft Tool and Manufacturing Company Site, Fairfield, Ohio

International Nuclear Information System (INIS)

Faillace, E.R.; Nimmagadda, M.; Yu, C.

1995-01-01

Residual radioactive material guidelines for uranium in soil were derived for the former Associate Aircraft Tool and Manufacturing Company site in Fairfield, Ohio. This site has been identified for remedial action under the U.S. Department of Energy's (DOE's) Formerly Utilized Sites Remedial Action Program (FUSRAP). Single-nuclide and total-uranium guidelines were derived on the basis of the requirement that, after remedial action, the 50-year committed effective dose equivalent to a hypothetical individual living or working in the immediate vicinity of the site should not exceed (1) 30 mrem/yr for the current-use and likely future-use scenarios or (2) 100 mrem/yr for less likely future-use scenarios. The DOE residual radioactive material (RESRAD) computer code, which implements the methodology described in the DOE manual for establishing residual radioactive material guidelines, was used in this evaluation

Response of equipment to aircraft impact

International Nuclear Information System (INIS)

Wolf, J.P.; Bucher, K.M.; Skrikerud, P.E.

1977-01-01

The loading case of an aircraft crashing onto certain safety-relevant buildings of a nuclear-power plant has recently become, in certain countries, as important as that of the safe-shutdown earthquake. Although its probability of occurrence is substantially smaller than that of the SSE, the analysis is justified as an aircraft can also be regarded as representative of other shock loading cases. For the purpose of design it is convenient to distinguish between the response of the actual structure and that of the equipment. The former, which consists of global stress resultants and of local effects such as spalling, scabbing, penetration and perforation of the concrete of the structure, is quite well understood and is not examined in this paper. The latter, caused by propagating shock waves, has, rather surprisingly, received little attention, although, for earthquake excitation, the analysis of equipment is routinely performed. The high accelerations experienced by the equipment are calculated and the corresponding floor-response spectra show that the airplane crash is dominant in the high-frequency range, when compared to the effect of earthquakes. As the aircraft impacts on a small area of the structure only, and the corresponding function of the load versus time exhibits a substantial content of high frequency, the modelling of the structure has to be rather detailed. Several thousand dynamic degrees of freedom in a finite-element idealization result, when analyzing e.g. a typical reactor auxiliary building, the familiar lumped-beam models used successfully for earthquake analysis can obviously not be chosen. (Auth.)

Radiation protection considerations of the use of thoriated magnesium alloys in aircrafts

International Nuclear Information System (INIS)

Schirmer, A.; Kersting, M.; Warnecke, U.

2016-01-01

For the improvement of high-temperature properties of Magnesium light-weight alloys for the construction of aircraft engines, research in the US and UK focussed also on Thorium as a constituent. As a result, large components of aircraft jet and shaft engines were made of Thorium-Magnesium alloys. Here the results of dose rate measurements are presented, which were performed by the Bundeswehr over decades. It shows up that type specific maximum values of the dose rate can be specified. In additional measurements the compiled data of the dose H_x (photon-equivalent dose) are related to current dose quantity (H*(10)). Using conservative values for the occupational dwell time near these engines the maximum annual dose for external exposure is estimated below 2 mSv. Dose contributions due to incorporation have not to be considered, since the work does not involve the formation of inhalable dust or smoke.

Modeled Full-Flight Aircraft Emissions Impacts on Air Quality and Their Sensitivity to Grid Resolution

Science.gov (United States)

Vennam, L. P.; Vizuete, W.; Talgo, K.; Omary, M.; Binkowski, F. S.; Xing, J.; Mathur, R.; Arunachalam, S.

2018-01-01

Aviation is a unique anthropogenic source with four-dimensional varying emissions, peaking at cruise altitudes (9–12 km). Aircraft emission budgets in the upper troposphere lower stratosphere region and their potential impacts on upper troposphere and surface air quality are not well understood. Our key objective is to use chemical transport models (with prescribed meteorology) to predict aircraft emissions impacts on the troposphere and surface air quality. We quantified the importance of including full-flight intercontinental emissions and increased horizontal grid resolution. The full-flight aviation emissions in the Northern Hemisphere contributed ~1.3% (mean, min–max: 0.46, 0.3–0.5 ppbv) and 0.2% (0.013, 0.004–0.02 μg/m3) of total O3 and PM2.5 concentrations at the surface, with Europe showing slightly higher impacts (1.9% (O3 0.69, 0.5–0.85 ppbv) and 0.5% (PM2.5 0.03, 0.01–0.05 μg/m3)) than North America (NA) and East Asia. We computed seasonal aviation-attributable mass flux vertical profiles and aviation perturbations along isentropic surfaces to quantify the transport of cruise altitude emissions at the hemispheric scale. The comparison of coarse (108 × 108 km2) and fine (36 × 36 km2) grid resolutions in NA showed ~70 times and ~13 times higher aviation impacts for O3 and PM2.5 in coarser domain. These differences are mainly due to the inability of the coarse resolution simulation to capture nonlinearities in chemical processes near airport locations and other urban areas. Future global studies quantifying aircraft contributions should consider model resolution and perhaps use finer scales near major aviation source regions. PMID:29707471

Modeled Full-Flight Aircraft Emissions Impacts on Air Quality and Their Sensitivity to Grid Resolution

Science.gov (United States)

Vennam, L. P.; Vizuete, W.; Talgo, K.; Omary, M.; Binkowski, F. S.; Xing, J.; Mathur, R.; Arunachalam, S.

2017-12-01

Aviation is a unique anthropogenic source with four-dimensional varying emissions, peaking at cruise altitudes (9-12 km). Aircraft emission budgets in the upper troposphere lower stratosphere region and their potential impacts on upper troposphere and surface air quality are not well understood. Our key objective is to use chemical transport models (with prescribed meteorology) to predict aircraft emissions impacts on the troposphere and surface air quality. We quantified the importance of including full-flight intercontinental emissions and increased horizontal grid resolution. The full-flight aviation emissions in the Northern Hemisphere contributed 1.3% (mean, min-max: 0.46, 0.3-0.5 ppbv) and 0.2% (0.013, 0.004-0.02 μg/m3) of total O3 and PM2.5 concentrations at the surface, with Europe showing slightly higher impacts (1.9% (O3 0.69, 0.5-0.85 ppbv) and 0.5% (PM2.5 0.03, 0.01-0.05 μg/m3)) than North America (NA) and East Asia. We computed seasonal aviation-attributable mass flux vertical profiles and aviation perturbations along isentropic surfaces to quantify the transport of cruise altitude emissions at the hemispheric scale. The comparison of coarse (108 × 108 km2) and fine (36 × 36 km2) grid resolutions in NA showed 70 times and 13 times higher aviation impacts for O3 and PM2.5 in coarser domain. These differences are mainly due to the inability of the coarse resolution simulation to capture nonlinearities in chemical processes near airport locations and other urban areas. Future global studies quantifying aircraft contributions should consider model resolution and perhaps use finer scales near major aviation source regions.

An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

Science.gov (United States)

Cheetham, B F

1983-01-01

Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation. PMID:6843551

Plasminogen activator inhibitor-1 5G/5G genotype is a protecting factor preventing posttransplant diabetes mellitus.

Science.gov (United States)

Chang, Horng-Rong; Yang, Shun-Fa; Tsai, Jen-Pi; Hsieh, Ming-Chia; Wu, Sheng-Wen; Tsai, Hui-Ching; Hung, Tung-Wei; Huang, Jun-Huang; Lian, Jong-Da

2011-01-30

Plasminogen activator inhibitor 1 (PAI-1) is thought to play a role in the pathogenesis of obesity and insulin resistance. A connection between gestational diabetes mellitus and the functional -675 PAI-1 genotype has been reported. Therefore, we examined the role of the PAI-1 gene polymorphism in kidney transplant recipients. A total of 376 kidney transplant recipients were prospectively screened for posttransplant diabetes mellitus (PTDM). Eighty-one (21.5%) patients were diagnosed with PTDM and the other 295 patients were non-diabetic following kidney transplantation. DNA samples were isolated from the sera and analyzed for the functional -675 4G/5G promoter polymorphisms of the PAI-1 gene. Kidney transplant recipients with PTDM were significantly associated with tacrolimus use (p=0.03), older age (p=0.036), and higher body mass index (p=0.001). The genotype distribution was significantly different between the patients with PTDM (genotype 4G/4G:4G/5G:5G/5G=33.3%:60.5%:6.2%) and those without PTDM (genotype 4G/4G:4G/5G:5G/5G=36.9%:44.1%:19.0%) (p=0.018). Patients with homozygosity for 5G had a significantly lower rate of PTDM (aOR, 0.286, p=0.022) and higher cumulative event-free probability of time to PTDM (log rank test, p=0.0058). Homozygosity for the 5G allele of the PAI-1 gene constitutes a protecting factor for the development of PTDM. Our findings are similar to a previous study on gestational diabetes mellitus, and strongly support a possible genetic role of PAI-1 in the development of PTDM. Copyright © 2010 Elsevier B.V. All rights reserved.

4G/5G and A-844G Polymorphisms of Plasminogen Activator Inhibitor-1 Associated with Glioblastoma in Iran--a Case-Control Study.

Science.gov (United States)

Pooyan, Honari; Ahmad, Ebrahimi; Azadeh, Rakhshan

2015-01-01

Glioblastoma is a highly aggressive and malignant brain tumor. Risk factors are largely unknown however, although several biomarkers have been identified which may support development, angiogenesis and invasion of tumor cells. One of these biomarkers is PAI-1. 4G/5G and A-844G are two common polymorphisms in the gene promotor of PAI 1 that may be related to high transcription and expression of this gene. Studies have shown that the prevalence of the 4G and 844G allele is significantly higher in patients with some cancers and genetic disorders. We here assessed the association of 4G/5G and A-844G polymorphisms with glioblastoma cancer risk in Iranians in a case-control study. All 71 patients with clinically confirmed and 140 volunteers with no history and symptoms of glioblastoma as control group were screened for 4G/5G and A-844G polymorphisms of PAI-1, using ARMS-PCR. Genotype and allele frequencies of case and control groups were analyzed using the DeFinetti program. Our results showed significant associations between 4G/5G (p=0.01824) and A-844G (p=0.02012) polymorphisms of the PAI-1 gene with glioblastoma cancer risk in our Iranian population. The results of this study supporting an association of the PAI-1 4G/5G (p=0.01824) and A-844G (p=0.02012) polymorphisms with increasing glioblastoma cancer risk in Iranian patients.

Aircraft Alerting Systems Criteria Study. Volume 1. Collation and Analysis of Aircraft Alerting Systems Data

Science.gov (United States)

1977-05-01

ott the.747-Vas opi the 7,37 beca’ws the � has foiiy paralkA.hydrauliu syst~et~s,’wfiereas %the 737 has only two patallel systems. is hefalue f wo...8217.. . -" "" - - - - - OLICTRICAL 2 2 13 2 10 1 EMERGENCY EQUIPMENT 1 1 1 1 - - , PIM PROTECTION 1 3 2 g 2 FLIGHT CONTROLS 2 2F,3 6 2 PLIGHT INITRUMINTATION a 2 a 4 1 1 1

Local damage to reinforced concrete structures caused by impact of aircraft engine missiles. Pt. 1

International Nuclear Information System (INIS)

Sugano, T.; Tsubota, H.; Kasai, Y.; Koshika, N.; Ohnuma, H.; Von Riesemann, W.A.; Bickel, D.C.; Parks, M.B.

1993-01-01

Structural damage induced by an aircraft crashing into a reinforced concrete structure includes local damage caused by the deformable engines, and global damage caused by the entire aircraft. Local damage to the target may consist of spalling of concrete from its front face together with missile penetration into it, scabbing of concrete from its rear face, and perforation of missile through it. Until now, local damage to concrete structures has been mainly evaluated by rigid missile impact tests. Past research work regarding local damage caused by impact of deformable missiles has been limited. This paper presents the results of a series of impact tests of small-, intermediate-, and full-scale engine models into reinforced concrete panels. The purpose of the tests was to determine the local damage to a reinforced concrete structure caused by the impact of a deformable aircraft engine. (orig.)

On the origin of the system PSR B 1757-24/SNR G 5.4-1.2

Science.gov (United States)

Gvaramadze, V. V.

2004-03-01

A scenario for the origin of the system PSR B 1757-24/supernova remnant (SNR) G 5.4-1.2 is proposed. It is suggested that both objects are the remnants of a supernova (SN) that exploded within a pre-existing bubble blown-up by a runaway massive star (the SN progenitor) during the final (Wolf-Rayet) phase of its evolution. This suggestion implies that (a) the SN blast centre was significantly offset from the geometric centre of the wind-blown bubble (i.e. from the centre of the future SNR), (b) the bubble was surrounded by a massive wind-driven shell, and (c) the SN blast wave was drastically decelerated by the interaction with the shell. Therefore, one can understand how the relatively young and low-velocity pulsar PSR B 1757-24 was able to escape from the associated SNR G 5.4-1.2 and why the inferred vector of pulsar transverse velocity does not point away from the geometric centre of the SNR. A possible origin of the radio source G 5.27-0.9 (located between PSR B 1757-24 and the SNR G 5.4-1.2) is proposed. It is suggested that G 5.27-0.9 is a lobe of a low Mach number (≃1.7) jet of gas outflowing from the interior of G 5.4-1.2 through the hole bored in the SNR's shell by the escaping pulsar. It is also suggested that the non-thermal emission of the comet-shaped pulsar wind nebula originates in the vicinity of the termination shock and in the cylindric region of subsonically moving shocked pulsar wind. The role of magnetized wind-driven shells (swept-up during the Wolf-Rayet phase from the ambient interstellar medium with the regular magnetic field) in formation of elongated axisymmetric SNRs is discussed.

Greenhouse effects of aircraft emissions

International Nuclear Information System (INIS)

Fortuin, J.P.F.; Wauben, W.M.F.; Dorland, R. van; Kelder, H.

1996-01-01

Ranges for direct and indirect greenhouse effects due to present day aircraft emissions are quantified for northern midlatitudes, using the concept of fixed temperature (FT) radiative forcing as calculated with a radiative transfer model. The direct greenhouse effects considered here are from emissions of carbon dioxide, water vapor, and nitrogen dioxide. To calculate the concentration increases of carbon dioxide and stratospheric water vapor, an analytical expression is developed based on a linear approximation of global fuel burn versus time. Unlike the expressions currently used in the literature, the authors' expression does not account for emission rates only, but also for a loss term--hence making it more suitable for shorter lived emittants. For midlatitude summer conditions, a total radiative forcing ranging from 0.04 to 0.09 Wm -2 is calculated for the direct greenhouse effects, whereas for midlatitude winter the range is 0.07 to 0.26 Wm -2 . The indirect greenhouse effects considered here are sulfate aerosol formation from sulfur dioxide emissions, contrail formation from emitted water vapor and condensation nuclei, and ozone formation from NO x emissions. The total radiative forcing coming from these indirect effects range from -0.67 to 0.25 Wm -2 in summer a/nd from -0.36 to 0.21 Wm -2 in winter. Further, the global distribution of NO x and ozone increases from aircraft emissions world-wide are simulated with a three-dimensional chemistry transport model for January and July. The geographical distribution of the radiative forcing associated with the simulated ozone increases is also calculated for these months

Hydrogen Storage for Aircraft Applications Overview

Science.gov (United States)

Colozza, Anthony J.; Kohout, Lisa (Technical Monitor)

2002-01-01

Advances in fuel cell technology have brought about their consideration as sources of power for aircraft. This power can be utilized to run aircraft systems or even provide propulsion power. One of the key obstacles to utilizing fuel cells on aircraft is the storage of hydrogen. An overview of the potential methods of hydrogen storage was compiled. This overview identifies various methods of hydrogen storage and points out their advantages and disadvantages relative to aircraft applications. Minimizing weight and volume are the key aspects to storing hydrogen within an aircraft. An analysis was performed to show how changes in certain parameters of a given storage system affect its mass and volume.

Integral Transportation Systems in Military Transport Aircraft Supply

Directory of Open Access Journals (Sweden)

Dražen Kovačević

2012-10-01

Full Text Available Supply of goods, equipment and soldiers by militwy transportaircraft can serve as a support to airborne landing operation,support to encircled forces, and support to forces leadinga gue1rilla war. Transport aircraft are designed in such a wayas to be able to cany containers, pallets, most of land vehiclesand helicopters. Militwy transport aircraft can be grouped intothose that were originally designed for military transp01t andthose that are modified civilian aircraft and helicopters. Supplypallets can be wooden, metal, can be airdropped in "taxiing","low-flight", and can also be fitted with a parachute or"retrorocket" for reducing the ground impact. Pallets canamong other things carry liquids, heavy combat and ca1rier vehicles,artillery and rocket weapons and valious containers.Pallets are usually pe1manently deformed at ground impact.Nowadays, high precision of airdrop has been achieved. Containersare used to carry various equipment, food, fue~ weapons,ammunition etc. It is to be expected that the containers,wmoured combat and other vehicles will be redesigned so asto provide more efficient transport and fast a!Tangement ofhigh-mobility units, whereas the form of the future militarytransport aircraft will not undergo substantial changes. By adjustingand standardising the transporlation vehicles, integraltransportation means and cwgo, the overall combat efficiencywill be increased, the a~rangement time especially shortenedand the air supply safety increased.

Pilot investigation - Nominal crew induced forces in zero-g

Science.gov (United States)

Klute, Glenn K.

1992-01-01

This report presents pilot-study data of test subject forces induced by intravehicular activities such as push-offs and landings with both hands and feet. Five subjects participated in this investigation. Three orthogonal force axes were measured in the NASA KC-135 research aircraft's 'zero-g' environment. The largest forces were induced during vertical foot push-offs, including one of 534 newtons (120 lbs). The mean vertical foot push-off was 311 newtons (70 lbs). The vertical hand push-off forces were also relatively large, including one of 267 newtons (60 lbs) with a mean of 151 newtons (34 lbs). These force magnitudes of these forces would result in a Shuttle gravity environment of about 1 x exp 10 -4 g's.

14 CFR 65.107 - Repairman certificate (light-sport aircraft): Eligibility, privileges, and limits.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Repairman certificate (light-sport aircraft... CREWMEMBERS Repairmen § 65.107 Repairman certificate (light-sport aircraft): Eligibility, privileges, and...-sport aircraft) and appropriate rating: To be eligible for You must (1) A repairman certificate (light...

Study of aircraft electrical power systems

Science.gov (United States)

1972-01-01

The formulation of a philosophy for devising a reliable, efficient, lightweight, and cost effective electrical power system for advanced, large transport aircraft in the 1980 to 1985 time period is discussed. The determination and recommendation for improvements in subsystems and components are also considered. All aspects of the aircraft electrical power system including generation, conversion, distribution, and utilization equipment were considered. Significant research and technology problem areas associated with the development of future power systems are identified. The design categories involved are: (1) safety-reliability, (2) power type, voltage, frequency, quality, and efficiency, (3) power control, and (4) selection of utilization equipment.

Estimation of nuclear power plant aircraft hazards

International Nuclear Information System (INIS)

Gottlieb, P.

1978-01-01

The standard procedures for estimating aircraft risk to nuclear power plants provide a conservative estimate, which is adequate for most sites, which are not close to airports or heavily traveled air corridors. For those sites which are close to facilities handling large numbers of aircraft movements (airports or corridors), a more precise estimate of aircraft impact frequency can be obtained as a function of aircraft size. In many instances the very large commercial aircraft can be shown to have an acceptably small impact frequency, while the very small general aviation aircraft will not produce sufficiently serious impact to impair the safety-related functions. This paper examines the in between aircraft: primarily twin-engine, used for business, pleasure, and air taxi operations. For this group of aircraft the total impact frequency was found to be approximately once in one million years, the threshold above which further consideration of specific safety-related consequences would be required

Aircraft Carrier Exposure Testing of Aircraft Materials

National Research Council Canada - National Science Library

Lee, Eui

2004-01-01

.... Test and control specimens were affixed on exposure racks and installed on aircraft carriers to compare adhesive bonding primers for aluminum and to determine the static property behavior of various...

Full scale aircraft impact test for evaluation of impact forces-Part 1

International Nuclear Information System (INIS)

Von Riesemann, W.A.; Parrish, R.L.; Bickel, D.C.; Heffelfinger, S.R.; Muto, K.; Sugano, T.; Tsubota, H.; Koshika, N.; Suzuki, M.; Ohrui, S.

1989-01-01

This paper describes a test conducted at an existing rocket sled facility in which an actual F-4 Phantom aircraft was impacted at a nominal velocity of 215 m/s into an essentially rigid block of concrete. This was accomplished by supporting the F-4 on four struts that were attached to the sled track by carriage shoes to direct the path of the aircraft. Propulsion was accomplished by two stages of rockets. The concrete target was floated on a set of air bearings. Data acquisition consisted of measurements of the acceleration of the fuselage and engines of the F-4, and measurements of the displacement, velocity and acceleration of the concrete target. High-speed photograph recorded the impact process and also permitted the determination of the impact velocity. This paper describes the test plan, method and results

Construction safety management guide for use with DOE Order 440.1

International Nuclear Information System (INIS)

1997-01-01

DOE Order (DOE O) 440.1, Worker Protection Management for DOE Federal and Contractor Employees, establishes the framework for an effective worker protection program to reduce or eliminate accidental losses, injuries, and illnesses by providing workers with places of employment free of recognized hazards. In addition to prescribing program requirements applicable to all activities performed by DOE and its contractors, DOE O 440.1 provides specific requirements applicable only to construction activities. The intent of these construction-specific requirements is to compel the proactive management of construction safety on a project-by-project basis and, to the greatest extent possible, integrate the management of safety and health, both in terms of project personnel and management methodologies, with the management of the other primary elements of construction project performance: quality, cost and schedule

AIRTV: Broadband Direct to Aircraft

Science.gov (United States)

Sorbello, R.; Stone, R.; Bennett, S. B.; Bertenyi, E.

2002-01-01

Airlines have been continuously upgrading their wide-body, long-haul aircraft with IFE (in-flight entertainment) systems that can support from 12 to 24 channels of video entertainment as well as provide the infrastructure to enable in-seat delivery of email and internet services. This is a direct consequence of increased passenger demands for improved in-flight services along with the expectations that broadband delivery systems capable of providing live entertainment (news, sports, financial information, etc.) and high speed data delivery will soon be available. The recent events of Sept. 11 have slowed the airline's upgrade of their IFE systems, but have also highlighted the compelling need for broadband aeronautical delivery systems to include operational and safety information. Despite the impact of these events, it is estimated that by 2005 more than 3000 long haul aircraft (servicing approximately 1 billion passengers annually) will be fully equipped with modern IFE systems. Current aircraft data delivery systems, which use either Inmarsat or NATS, are lacking in bandwidth and consequently are unsuitable to satisfy passenger demands for broadband email/internet services or the airlines' burgeoning data requirements. Present live video delivery services are limited to regional coverage and are not readily expandable to global or multiregional service. Faced with a compelling market demand for high data transport to aircraft, AirTV has been developing a broadband delivery system that will meet both passengers' and airlines' needs. AirTV is a global content delivery system designed to provide a range of video programming and data services to commercial airlines. When AirTV is operational in 2004, it will provide a broadband connection directly to the aircraft, delivering live video entertainment, internet/email service and essential operational and safety data. The system has been designed to provide seamless global service to all airline routes except for those

The Association of Plasminogen Activator Inhibitor Type 1 (PAI-1) Level and PAI-1 4G/5G Gene Polymorphism with the Formation and the Grade of Endometrial Cancer.

Science.gov (United States)

Yıldırım, Malik Ejder; Karakuş, Savas; Kurtulgan, Hande Küçük; Kılıçgün, Hasan; Erşan, Serpil; Bakır, Sevtap

2017-08-01

Plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor (Serpine 1), and it inhibits both tissue plasminogen activator and urokinase plasminogen activator which are important in fibrinolysis. We aimed to find whether there is a possible association between PAI-1 level, PAI-1 4G/5G polymorphism, and endometrial cancer. PAI-1 levels in peripheral blood were determined in 82 patients with endometrial carcinoma and 76 female healthy controls using an enzyme-linked immunoassay (ELISA). Then, the genomic DNA was extracted and screened by reverse hybridization procedure (Strip assay) to detect PAI 1 4G/5G polymorphism. The levels of PAI-1 in the patients were higher statistically in comparison to controls (P 5G polymorphism was quite different between patients and controls (P = 0.008), and 4G allelic frequency was significantly higher in the patients of endometrial cancer than in controls (P = 0.026). We found significant difference between Grade 1 and Grade 2+3 patients in terms of the PAI-1 levels (P = 0.047). There was no association between PAI-1 4G/5G polymorphism and the grades of endometrial cancer (P = 0.993). Our data suggest that the level of PAI-1 and PAI-1 4G/5G gene polymorphism are effective in the formation of endometrial cancer. PAI-1 levels are also associated with the grades of endometrial cancer.

Lift/cruise fan V/STOL technology aircraft design definition study. Volume 1: Technology flight vehicle definition

Science.gov (United States)

Obrien, W. J.

1976-01-01

Concept design is presented for two types of lift/cruise fan technology V/STOL aircraft, turbotip fans and the other using mechanically driven fans. The turbotip research technology aircraft reflects maximum usage of existing airframe components. The propulsion system consists of three turbotip fans pneumatically interconnected to three gas generators. Thrust modulation is accomplished by use of energy transfer and control system and thrust reduction modulation. This system can also be operated in the two engine/three fan mode. The mechanical RTA is virtually identical to the turbotip RTA with the exceptions that a different propulsion system and aft fuselage/tail are used. Both aircraft meet or exceed all of the mission performance guidelines and reflect a low cost, low risk approach.

PAI-1 expression and its regulation by promoter 4G/5G polymorphism in clear cell renal cell carcinoma.

Science.gov (United States)

Choi, Jung-Woo; Lee, Ju-Han; Park, Hong Seok; Kim, Young-Sik

2011-10-01

To characterise patients with high plasminogen activator inhibitor-1 (PAI-1) expression as oral PAI-1 antagonists are currently in preclinical trials, and to determine whether the PAI-1 promoter 4G/5G polymorphism regulates PAI-1 expression in clear cell renal cell carcinoma (CCRCC). PAI-1 expression was examined by immunohistochemistry in 69 CCRCC specimens. In addition, the promoter 4G/5G polymorphism was investigated by both allele-specific PCR and direct DNA sequencing. PAI-1 was overexpressed in 25/69 (36.2%) patients with CCRCC. PAI-1 staining was intense in tumour cells with a high Fuhrman nuclear grade and in spindle-shaped tumour cells. PAI-1 expression was significantly associated with older age at diagnosis (p=0.027), high nuclear grade (p5G and 31.9% (22/69) 5G/5G. The homozygous 4G/4G or 5G/5G group showed a tendency for a high nuclear grade (p=0.05) but the 4G/5G polymorphism was not related to other prognostic parameters. PAI-1 expression was poorly correlated with its promoter 4G/5G polymorphism (Spearman ρ=0.088). CCRCC with high PAI-1 expression is characterised by older age, high nuclear grade, advanced stage, distant metastasis and/or shortened disease-free survival. PAI-1 expression is not affected by the promoter 4G/5G polymorphism.

Vestibular Stimulus and Perceived Roll Tilt During Coordinated Turns in Aircraft and Gondola Centrifuge.

Science.gov (United States)

Tribukait, Arne; Ström, Adrian; Bergsten, Eddie; Eiken, Ola

2016-05-01

One disorienting movement pattern, common during flight, is the entering of a coordinated turn. While the otoliths persistently sense upright head position, the change in roll attitude constitutes a semicircular canal stimulus. This sensory conflict also arises during acceleration in a swing-out gondola centrifuge. From a vestibular viewpoint there are, however, certain differences between the two stimulus situations; the aim of the present study was to elucidate whether these differences are reflected in the perceived roll attitude. Eight nonpilots were tested in a centrifuge (four runs) and during flight (two turns). The subjective visual horizontal (SVH) was measured using an adjustable luminous line in darkness. The centrifuge was accelerated from stationary to 1.56 G (roll 50°) within 7 s; the duration of the G plateau was 5 min. With the aircraft, turns with approximately 1.4 G (45°) were entered within 15 s and lasted for 5 min. Tilt perception (TP) was defined as the ratio of SVH/real roll tilt; initial and final values were calculated for each centrifugation/turn. In both systems there was a sensation of tilt that declined with time. The initial TP was (mean ± SD): 0.40 ± 0.27 (centrifuge) and 0.37 ± 0.30 (flight). The final TP was 0.20 ± 0.26 and 0.17 ± 0.19, respectively. Both initial and final TP correlated between the two conditions. The physical roll tilt is under-estimated to a similar degree in the centrifuge and aircraft. Also the correspondence at the individual level suggests that the vestibular dilemma of coordinated flight can be recreated in a lifelike manner using a gondola centrifuge.

Physical Condition Does Not Affect Gravity-Induced Loss of Consciousness during Human Centrifuge Training in Well-Experienced Young Aviators.

Directory of Open Access Journals (Sweden)

Jinhee Park

Full Text Available Consensus on whether physical condition affects the risk of gravity-induced loss of consciousness (G-LOC has not been reached, and most previous studies about the issue did not include well-experienced aviators. We compared the physical conditions of well-experienced young aviators according to the occurrence of G-LOC during human centrifuge training.Among 361 young male aviators on active flight duty with experience in high performance aircrafts for at least 2 years, 350 had full data available and were reviewed in this study. We divided the aviators into the G-LOC group and the non-G-LOC group according to their human centrifuge training results. We then compared their basic characteristics, body composition, physical fitness level, and pulmonary function.Twenty nine aviators (8.3% who experienced G-LOC during human centrifuge training in their first trials were classified into the G-LOC group. There was no difference in physical condition of aviators between the two groups.Young aviators with experience in G-LOC showed no difference in physical condition such as muscle mass, strength, and general endurance from the aviators with no such experience. Although more studies are needed, physical condition does not seem to be a significant determinant of G-LOC among the experienced aviators.

Physical Condition Does Not Affect Gravity-Induced Loss of Consciousness during Human Centrifuge Training in Well-Experienced Young Aviators.

Science.gov (United States)

Park, Jinhee; Yun, Chul; Kang, Seungcheol

2016-01-01

Consensus on whether physical condition affects the risk of gravity-induced loss of consciousness (G-LOC) has not been reached, and most previous studies about the issue did not include well-experienced aviators. We compared the physical conditions of well-experienced young aviators according to the occurrence of G-LOC during human centrifuge training. Among 361 young male aviators on active flight duty with experience in high performance aircrafts for at least 2 years, 350 had full data available and were reviewed in this study. We divided the aviators into the G-LOC group and the non-G-LOC group according to their human centrifuge training results. We then compared their basic characteristics, body composition, physical fitness level, and pulmonary function. Twenty nine aviators (8.3%) who experienced G-LOC during human centrifuge training in their first trials were classified into the G-LOC group. There was no difference in physical condition of aviators between the two groups. Young aviators with experience in G-LOC showed no difference in physical condition such as muscle mass, strength, and general endurance from the aviators with no such experience. Although more studies are needed, physical condition does not seem to be a significant determinant of G-LOC among the experienced aviators.

26 CFR 1.883-1 - Exclusion of income from the international operation of ships or aircraft.

Science.gov (United States)

2010-04-01

... alliances between or among international carriers which also include joint marketing, baggage handling, one... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Exclusion of income from the international... Exclusion of income from the international operation of ships or aircraft. (a) General rule. Qualified...

76 FR 48047 - Airworthiness Directives; Diamond Aircraft Industries Powered Sailplanes

Science.gov (United States)

2011-08-08

... 5 p.m., Monday through Friday, except Federal holidays. For service information identified in this... Service Information Diamond Aircraft Industries GmbH has issued Service Bulletin No. MSB 36-105/1, dated...-105, dated April 21, 2011, as specified in Diamond Aircraft Industries GmbH Service Bulletin No. MSB...

Aircraft Fuel Cell Power Systems

Science.gov (United States)

Needham, Robert

2004-01-01

In recent years, fuel cells have been explored for use in aircraft. While the weight and size of fuel cells allows only the smallest of aircraft to use fuel cells for their primary engines, fuel cells have showed promise for use as auxiliary power units (APUs), which power aircraft accessories and serve as an electrical backup in case of an engine failure. Fuel cell MUS are both more efficient and emit fewer pollutants. However, sea-level fuel cells need modifications to be properly used in aircraft applications. At high altitudes, the ambient air has a much lower pressure than at sea level, which makes it much more difficult to get air into the fuel cell to react and produce electricity. Compressors can be used to pressurize the air, but this leads to added weight, volume, and power usage, all of which are undesirable things. Another problem is that fuel cells require hydrogen to create electricity, and ever since the Hindenburg burst into flames, aircraft carrying large quantities of hydrogen have not been in high demand. However, jet fuel is a hydrocarbon, so it is possible to reform it into hydrogen. Since jet fuel is already used to power conventional APUs, it is very convenient to use this to generate the hydrogen for fuel-cell-based APUs. Fuel cells also tend to get large and heavy when used for applications that require a large amount of power. Reducing the size and weight becomes especially beneficial when it comes to fuel cells for aircraft. My goal this summer is to work on several aspects of Aircraft Fuel Cell Power System project. My first goal is to perform checks on a newly built injector rig designed to test different catalysts to determine the best setup for reforming Jet-A fuel into hydrogen. These checks include testing various thermocouples, transmitters, and transducers, as well making sure that the rig was actually built to the design specifications. These checks will help to ensure that the rig will operate properly and give correct results

The Aircraft Morphing Program

Science.gov (United States)

Wlezien, R. W.; Horner, G. C.; McGowan, A. R.; Padula, S. L.; Scott, M. A.; Silcox, R. J.; Simpson, J. O.

1998-01-01

In the last decade smart technologies have become enablers that cut across traditional boundaries in materials science and engineering. Here we define smart to mean embedded actuation, sensing, and control logic in a tightly coupled feedback loop. While multiple successes have been achieved in the laboratory, we have yet to see the general applicability of smart devices to real aircraft systems. The NASA Aircraft Morphing program is an attempt to couple research across a wide range of disciplines to integrate smart technologies into high payoff aircraft applications. The program bridges research in seven individual disciplines and combines the effort into activities in three primary program thrusts. System studies are used to assess the highest- payoff program objectives, and specific research activities are defined to address the technologies required for development of smart aircraft systems. In this paper we address the overall program goals and programmatic structure, and discuss the challenges associated with bringing the technologies to fruition.

Wireless Local Area Network Performance Inside Aircraft Passenger Cabins

Science.gov (United States)

Whetten, Frank L.; Soroker, Andrew; Whetten, Dennis A.; Whetten, Frank L.; Beggs, John H.

2005-01-01

An examination of IEEE 802.11 wireless network performance within an aircraft fuselage is performed. This examination measured the propagated RF power along the length of the fuselage, and the associated network performance: the link speed, total throughput, and packet losses and errors. A total of four airplanes: one single-aisle and three twin-aisle airplanes were tested with 802.11a, 802.11b, and 802.11g networks.

The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels.

Science.gov (United States)

Sogutlu Sari, Esin; Yazici, Alper; Eser, Betül; Erol, Muhammet Kazim; Kilic, Adil; Ermis, Sitki Samet; Koytak, Arif; Akşit, Hasan; Yakut, Tahsin

2014-12-01

Central serous chorioretinopathy (CSCR) is a poorly understood disease and the choroidal circulation abnormality induced by the plasminogen activator inhibitor type 1 (PAI-1) seems to be associated with the pathogenesis. There are many reports indicating that 4 G/5 G polymorphism of the PAI-1 gene is a risk factor for several diseases related to the elevated serum levels of PAI-1. To evaluate the 4 G/5 G polymorphism of the PAI-1 gene and its association with serum levels of PAI-1 in acute CSCR patients. Sixty CSCR patients and 50 healthy control patients were included. The PAI-1 4 G/5 G was genotyped using the polymerase chain reaction-restriction technique. Serum PAI-1 level was measured using enzyme-linked immunosorbent assay. Demographic data consisting of age, sex, body mass index (BMI) as well as genotype disturbances and serum PAI-1 levels were compared between the groups. Statistical significance for differences in the serum PAI-1 levels of each group with different genotypes was also analyzed. The CSCR group consisted of 40 male (66.7%) and 20 female (33.3%) patients with a mean age of 46.7 ± 8.39 years. The control group consisted of 32 male (64%) and 18 female (36%) healthy subjects with a mean age of 45.8 ± 8.39 years. There was no statistically significant difference between the groups in terms of age, sex and BMI. In the CSCR group the genotype frequencies were 4 G/4G: 30% (n = 18), 4G/5 G: 50% (n = 30), 5 G/5G: 20% (n = 12) and in the control group genotype frequencies were 34% (n = 17), 42% (n = 21) and 24% (n = 12), respectively. There was no statistically significant difference in the distribution of genotypes among the groups (chi-squared, p = 0.70). The CSCR group had a significantly higher serum PAI-1 concentration than the control group (p = 0.001). In both groups the mean plasma PAI-1 concentration did not vary significantly among the different genotypes (p > 0.05). Although our results demonstrated that the patients with acute CSCR have

Smart aircraft fastener evaluation (SAFE) system: a condition-based corrosion detection system for aging aircraft

Science.gov (United States)

Schoess, Jeffrey N.; Seifert, Greg; Paul, Clare A.

1996-05-01

The smart aircraft fastener evaluation (SAFE) system is an advanced structural health monitoring effort to detect and characterize corrosion in hidden and inaccessible locations of aircraft structures. Hidden corrosion is the number one logistics problem for the U.S. Air Force, with an estimated maintenance cost of $700M per year in 1990 dollars. The SAFE system incorporates a solid-state electrochemical microsensor and smart sensor electronics in the body of a Hi-Lok aircraft fastener to process and autonomously report corrosion status to aircraft maintenance personnel. The long-term payoff for using SAFE technology will be in predictive maintenance for aging aircraft and rotorcraft systems, fugitive emissions applications such as control valves, chemical pipeline vessels, and industrial boilers. Predictive maintenance capability, service, and repair will replace the current practice of scheduled maintenance to substantially reduce operational costs. A summary of the SAFE concept, laboratory test results, and future field test plans is presented.

The Plasminogen Activator Inhibitor 1 4G/5G Polymorphism and the Risk of Alzheimer's Disease.

Science.gov (United States)

Fekih-Mrissa, Najiba; Mansour, Malek; Sayeh, Aicha; Bedoui, Ines; Mrad, Meriem; Riahi, Anis; Mrissa, Ridha; Nsiri, Brahim

2017-09-01

The aim of this study was to determine whether plasminogen activator inhibitor 1 (PAI-1) is associated with the risk of Alzheimer's disease (AD) in Tunisian patients. We analyzed the genotype and allele frequency distribution of the PAI-1 polymorphism in 60 Tunisian patients with AD and 120 healthy controls. The results show a significantly increased risk of AD in carriers of the 4G/4G and 4G/5G genotypes versus the wild-type 5G/5G genotype (4G/4G: 28.33% in patients vs 10.0% in controls; P 5G: 55.0% in patients vs 38.33% in controls; OR = 4.45; P < 10 -3 ). The 4G allele was also more frequently found in patients compared with controls; P < 10 -3 ; OR = 3.07. For all participants and by gender, homozygotic carriers (4G/4G) were at an increased risk of AD over heterozygotes and women were at an increased risk over their male genotype counterparts. The odds ratio for AD among 4G/4G carriers for any group was approximately twice that of heterozygotes in the same group. Women homozygotes ranked highest for AD risk (OR = 20.8) and, in fact, women heterozygotes (OR = 9.03) ranked higher for risk than male homozygotes (OR = 6.12). These preliminary exploratory results should be confirmed in a larger study.

Aircraft Emission Scenarios Projected in Year 2015 for the NASA Technology Concept Aircraft (TCA) High Speed Civil Transport

Science.gov (United States)

Baughcum, Steven L.; Henderson, Stephen C.

1998-01-01

This report describes the development of a three-dimensional database of aircraft fuel burn and emissions (fuel burned, NOx, CO, and hydrocarbons) from projected fleets of high speed civil transports (HSCTs) on a universal airline network. Inventories for 500 and 1000 HSCT fleets, as well as the concurrent subsonic fleets, were calculated. The HSCT scenarios are calculated using the NASA technology concept airplane (TCA) and update an earlier report. These emissions inventories are available for use by atmospheric scientists conducting the Atmospheric Effects of Stratospheric Aircraft (AESA) modeling studies. Fuel burned and emissions of nitrogen oxides (NOx as NO2), carbon monoxide, and hydrocarbons have been calculated on a 1 degree latitude x 1 degree longitude x 1 kilometer pressure altitude grid and delivered to NASA as electronic files.

75 FR 41986 - Certification of Aircraft and Airmen for the Operation of Light-Sport Aircraft; Modifications to...

Science.gov (United States)

2010-07-20

...- Sport Aircraft; Modifications to Rules for Sport Pilots and Flight Instructors With a Sport Pilot Rating... rule; OMB approval of information collection. SUMMARY: This document announces the Office of Management... rule, ``Certification of Aircraft and Airmen for the Operation of Light-Sport Aircraft; Modifications...

Methodology to Improve Aviation Security With Terrorist Using Aircraft as a Weapon

Science.gov (United States)

2013-09-01

of aircraft was traced to 1931 in Peru (Jenkins, n.d.). Since then, aircraft have been hijacked for various reasons ranging from hijackers seeking...1.5.2 Tourism 1.5.3 ... Figure 7. Process Decomposition17 of Airport System. 2. Passenger Process Decomposition As each stakeholder has

Clinicopathological significance of plasminogen activator inhibitor-1 promoter 4G/5G polymorphism in breast cancer: a meta-analysis.

Science.gov (United States)

Lee, Ju-Han; Kim, Younghye; Choi, Jung-Woo; Kim, Young-Sik

2013-01-01

Plasminogen activator inhibitor type 1 (PAI-1) is associated with poor prognosis in breast cancer. Transcriptional expression of the PAI-1 can be controlled by PAI-1 promoter 4G/5G polymorphism. However, the significance of PAI-1 promoter 4G/5G polymorphism in breast cancer patients is contentious. To address this controversy, we conducted a meta-analysis for the relationships between PAI-1 promoter polymorphism and clinicopathological characteristics of breast cancer. Relevant published studies were identified using a search of PubMed, Embase, and the ISI Web of Science. The effect sizes of PAI-1 promoter 4G/5G polymorphism on breast cancer risk, lymph node metastasis, histologic grade, and overall survival were calculated by odds ratio (OR) or hazard ratio. The effect sizes were combined using a random-effects model. Individuals with 4G/4G genotype had a higher risk of breast cancer than those with the combined 4G/5G and 5G/5G genotypes (OR = 1.388; p = 0.031). Breast cancer patients with the 5G/5G genotype displayed lymph node metastasis more than patients with either the combined other genotypes (OR = 1.495; p = 0.027) or with the 4G/4G genotype (OR = 1.623; p = 0.018). However, the PAI-1 promoter 4G/5G polymorphism was not associated with histological grade or overall survival. PAI-1 promoter 4G/5G polymorphism is associated with a relatively increased risk of breast cancer development and lymph node metastasis. Copyright © 2013 IMSS. Published by Elsevier Inc. All rights reserved.

Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident

Directory of Open Access Journals (Sweden)

Tanja Laukkala

2018-03-01

Full Text Available Aircraft-assisted pilot suicide is a rare but serious phenomenon. The aim of this study was to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps. Aircraft-assisted pilot suicides were searched in the U.S. National Transportation Safety Board (NTSB accident investigation database and in the German Bundestelle für Flugunfalluntersuchung (BFU Reports of Investigation database five years before and two years after the deliberate crash of the Germanwings flight into the French Alps in 2015. The relative risk (RR of the aircraft-assisted pilot suicides was calculated. Two years after the incident, three out of 454 (0.66% fatal incidents were aircraft-assisted suicides compared with six out of 1292 (0.46% in the prior five years in the NTSB database. There were no aircraft-assisted pilot suicides in the German database during the two years after or five years prior to the Germanwings crash. The relative aircraft-assisted pilot suicide risk for the U.S. was 1.4 (95% CI 0.3–4.2 which was not statistically significant. Six of the pilots who died by suicide had told someone of their suicidal intentions. We consider changes in the rate to be within a normal variation. Responsible media coverage of aircraft incidents is important due to the large amount of publicity that these events attract.

Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident

Science.gov (United States)

Vuorio, Alpo; Bor, Robert; Budowle, Bruce; Navathe, Pooshan; Pukkala, Eero; Sajantila, Antti

2018-01-01

Aircraft-assisted pilot suicide is a rare but serious phenomenon. The aim of this study was to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps. Aircraft-assisted pilot suicides were searched in the U.S. National Transportation Safety Board (NTSB) accident investigation database and in the German Bundestelle für Flugunfalluntersuchung (BFU) Reports of Investigation database five years before and two years after the deliberate crash of the Germanwings flight into the French Alps in 2015. The relative risk (RR) of the aircraft-assisted pilot suicides was calculated. Two years after the incident, three out of 454 (0.66%) fatal incidents were aircraft-assisted suicides compared with six out of 1292 (0.46%) in the prior five years in the NTSB database. There were no aircraft-assisted pilot suicides in the German database during the two years after or five years prior to the Germanwings crash. The relative aircraft-assisted pilot suicide risk for the U.S. was 1.4 (95% CI 0.3–4.2) which was not statistically significant. Six of the pilots who died by suicide had told someone of their suicidal intentions. We consider changes in the rate to be within a normal variation. Responsible media coverage of aircraft incidents is important due to the large amount of publicity that these events attract. PMID:29534475

26 CFR 301.6503(g)-1 - Suspension pending correction.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Suspension pending correction. 301.6503(g)-1 Section 301.6503(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Collection § 301.6503(g)-1 Suspension pending correction. The running of the periods of limitations provided...

Impact analysis of composite aircraft structures

Science.gov (United States)

Pifko, Allan B.; Kushner, Alan S.

1993-01-01

The impact analysis of composite aircraft structures is discussed. Topics discussed include: background remarks on aircraft crashworthiness; comments on modeling strategies for crashworthiness simulation; initial study of simulation of progressive failure of an aircraft component constructed of composite material; and research direction in composite characterization for impact analysis.

Damage Tolerant Repair Techniques for Pressurized Aircraft Fuselages

Science.gov (United States)

1994-01-01

RepoW Techniques for Prwurized Aircraft AXWdOg 4.9 Summary and Conclusions The basics of adhesive bonded repairs for aluminum aircraft fuselages have... of cruise altitude and bending stresses in the plate at the tip of one-sided reinforcements (chapter 5). The expanded Rose model was transformed into a...DEPARTMEN1 OF THE AIR FORCE AGENCY REPORT NUMBER AFIT/CI 2950 P STREET WRIGHT-PATTERSON AFB OH 45433-7765 11. SUPPLEMENTARY NOTES Usa. DISTRUISUIOII

Vehicle Design Evaluation Program (VDEP). A computer program for weight sizing, economic, performance and mission analysis of fuel-conservative aircraft, multibodied aircraft and large cargo aircraft using both JP and alternative fuels

Science.gov (United States)

Oman, B. H.

1977-01-01

The NASA Langley Research Center vehicle design evaluation program (VDEP-2) was expanded by (1) incorporating into the program a capability to conduct preliminary design studies on subsonic commercial transport type aircraft using both JP and such alternate fuels as hydrogen and methane;(2) incorporating an aircraft detailed mission and performance analysis capability; and (3) developing and incorporating an external loads analysis capability. The resulting computer program (VDEP-3) provides a preliminary design tool that enables the user to perform integrated sizing, structural analysis, and cost studies on subsonic commercial transport aircraft. Both versions of the VDEP-3 Program which are designated preliminary Analysis VDEP-3 and detailed Analysis VDEP utilize the same vehicle sizing subprogram which includes a detailed mission analysis capability, as well as a geometry and weight analysis for multibodied configurations.

Advanced technologies and new roles for VTOL aircraft (Part 1/2)

Energy Technology Data Exchange (ETDEWEB)

Renaud, J.P. [Office National d' Etudes et de Recherches Aerospatiales (ONERA) (France); Aix-Marseille-2 Univ., 13 - Marseille (France)

2000-04-01

This survey paper intends to overview some main technical evolutions impacting present and future general design of rotor-craft (for vehicles, engines and systems), including helicopter and future tilt-rotor. These trends tend to achieve a better adaptation to a wide range of mission requirements with an economic aircraft optimization and an enhanced safety level and environmental impact. (author)

Lisosan G, a powder of grain, does not interfere with the drug metabolizing enzymes and has a protective role on carbon tetrachloride-induced hepatotoxicity.

Science.gov (United States)

Longo, Vincenzo; Chirulli, Vera; Gervasi, Pier Giovanni; Nencioni, Simona; Pellegrini, Michela

2007-08-01

Lisosan G is a powder of grain registered as an alimentary integrator. The treatment of rats for 4 days with 0.5 g Lisosan G/kg had no effect on various drug metabolizing enzymes. Experiments in vitro showed that Lisosan G had radical scavenger activity. A confirmation of the antioxidative property of Lisosan G was also confirmed when it was administered in vivo to carbon tetrachloride (CCl(4))-intoxicated rats. The toxicity caused by CCl(4)-treatment of rats was restored to the control levels when the rats were given Lisosan G for 4 days before CCl(4). Lisosan G thus does not interfere with drug metabolizing system but has antioxidant properties and protects against CCl(4)-induced hepatotoxicity.

Assessing the role of anthropogenic and biogenic sources on PM1 over southern West Africa using aircraft measurements

Science.gov (United States)

Brito, Joel; Freney, Evelyn; Dominutti, Pamela; Borbon, Agnes; Haslett, Sophie L.; Batenburg, Anneke M.; Colomb, Aurelie; Dupuy, Regis; Denjean, Cyrielle; Burnet, Frederic; Bourriane, Thierry; Deroubaix, Adrien; Sellegri, Karine; Borrmann, Stephan; Coe, Hugh; Flamant, Cyrille; Knippertz, Peter; Schwarzenboeck, Alfons

2018-01-01

As part of the Dynamics-Aerosol-Chemistry-Cloud Interactions in West Africa (DACCIWA) project, an airborne campaign was designed to measure a large range of atmospheric constituents, focusing on the effect of anthropogenic emissions on regional climate. The presented study details results of the French ATR42 research aircraft, which aimed to characterize gas-phase, aerosol and cloud properties in the region during the field campaign carried out in June/July 2016 in combination with the German Falcon 20 and the British Twin Otter aircraft. The aircraft flight paths covered large areas of Benin, Togo, Ghana and Côte d'Ivoire, focusing on emissions from large urban conurbations such as Abidjan, Accra and Lomé, as well as remote continental areas and the Gulf of Guinea. This paper focuses on aerosol particle measurements within the boundary layer (view of the complex mix of both biogenic and anthropogenic emissions, based on measurements from a compact time-of-flight aerosol mass spectrometer (C-ToF-AMS) and ancillary instrumentation. Background concentrations (i.e. outside urban plumes) observed from the ATR42 indicate a fairly polluted region during the time of the campaign, with average concentrations of carbon monoxide of 131 ppb, ozone of 32 ppb, and aerosol particle number concentration ( > 15 nm) of 735 cm-3 stp. Regarding submicron aerosol composition (considering non-refractory species and black carbon, BC), organic aerosol (OA) is the most abundant species contributing 53 %, followed by SO4 (27 %), NH4 (11 %), BC (6 %), NO3 (2 %) and minor contribution of Cl (< 0.5 %). Average background PM1 in the region was 5.9 µg m-3 stp. During measurements of urban pollution plumes, mainly focusing on the outflow of Abidjan, Accra and Lomé, pollutants are significantly enhanced (e.g. average concentration of CO of 176 ppb, and aerosol particle number concentration of 6500 cm-3 stp), as well as PM1 concentration (11.9 µg m-3 stp). Two classes of organic aerosols were

The Enforcer Aircraft Program: A Lower-Cost Alternative Weapon System.

Science.gov (United States)

1984-03-01

armoured striking forces. NATO’s air forces then, sns 1.select the optimum aircraft(s) to maximize the damage to the enemy while minimizing the cost to...the reascns Congress kept the Enforcer program alive was their inclination to support the underdog , an underdog with persuasiveness and tenacity. To

G-LiHT: Goddard's LiDAR, Hyperspectral and Thermal Airborne Imager

Science.gov (United States)

Cook, Bruce; Corp, Lawrence; Nelson, Ross; Morton, Douglas; Ranson, Kenneth J.; Masek, Jeffrey; Middleton, Elizabeth

2012-01-01

Scientists at NASA's Goddard Space Flight Center have developed an ultra-portable, low-cost, multi-sensor remote sensing system for studying the form and function of terrestrial ecosystems. G-LiHT integrates two LIDARs, a 905 nanometer single beam profiler and 1550 nm scanner, with a narrowband (1.5 nanometers) VNIR imaging spectrometer and a broadband (8-14 micrometers) thermal imager. The small footprint (approximately 12 centimeters) LIDAR data and approximately 1 meter ground resolution imagery are advantageous for high resolution applications such as the delineation of canopy crowns, characterization of canopy gaps, and the identification of sparse, low-stature vegetation, which is difficult to detect from space-based instruments and large-footprint LiDAR. The hyperspectral and thermal imagery can be used to characterize species composition, variations in biophysical variables (e.g., photosynthetic pigments), surface temperature, and responses to environmental stressors (e.g., heat, moisture loss). Additionally, the combination of LIDAR optical, and thermal data from G-LiHT is being used to assess forest health by sensing differences in foliage density, photosynthetic pigments, and transpiration. Low operating costs (approximately $1 ha) have allowed us to evaluate seasonal differences in LiDAR, passive optical and thermal data, which provides insight into year-round observations from space. Canopy characteristics and tree allometry (e.g., crown height:width, canopy:ground reflectance) derived from G-LiHT data are being used to generate realistic scenes for radiative transfer models, which in turn are being used to improve instrument design and ensure continuity between LiDAR instruments. G-LiHT has been installed and tested in aircraft with fuselage viewports and in a custom wing-mounted pod that allows G-LiHT to be flown on any Cessna 206, a common aircraft in use throughout the world. G-LiHT is currently being used for forest biomass and growth estimation

Histone H1 interphase phosphorylation becomes largely established in G1 or early S phase and differs in G1 between T-lymphoblastoid cells and normal T cells

Directory of Open Access Journals (Sweden)

Gréen Anna

2011-08-01

Full Text Available Abstract Background Histone H1 is an important constituent of chromatin, and is involved in regulation of its structure. During the cell cycle, chromatin becomes locally decondensed in S phase, highly condensed during metaphase, and again decondensed before re-entry into G1. This has been connected to increasing phosphorylation of H1 histones through the cell cycle. However, many of these experiments have been performed using cell-synchronization techniques and cell cycle-arresting drugs. In this study, we investigated the H1 subtype composition and phosphorylation pattern in the cell cycle of normal human activated T cells and Jurkat T-lymphoblastoid cells by capillary electrophoresis after sorting of exponentially growing cells into G1, S and G2/M populations. Results We found that the relative amount of H1.5 protein increased significantly after T-cell activation. Serine phosphorylation of H1 subtypes occurred to a large extent in late G1 or early S phase in both activated T cells and Jurkat cells. Furthermore, our data confirm that the H1 molecules newly synthesized during S phase achieve a similar phosphorylation pattern to the previous ones. Jurkat cells had more extended H1.5 phosphorylation in G1 compared with T cells, a difference that can be explained by faster cell growth and/or the presence of enhanced H1 kinase activity in G1 in Jurkat cells. Conclusion Our data are consistent with a model in which a major part of interphase H1 phosphorylation takes place in G1 or early S phase. This implies that H1 serine phosphorylation may be coupled to changes in chromatin structure necessary for DNA replication. In addition, the increased H1 phosphorylation of malignant cells in G1 may be affecting the G1/S transition control and enabling facilitated S-phase entry as a result of relaxed chromatin condensation. Furthermore, increased H1.5 expression may be coupled to the proliferative capacity of growth-stimulated T cells.

Evidence for the frequency-shift of the OA A_1g mode in Hg-based superconductors

Science.gov (United States)

Yang, In-Sang; Lee, Hye-Gyong

1996-03-01

The Hg-based superconductors, HgBa_2Ca_n-1Cu_nO_2n+2+δ (n=1,2,3) have two strong Raman peaks at ~ 570 and 590 cm-1 in the high-frequency region. From the results of Raman measurements of Tl-doped Hg-1223 system, it is concluded that the peak at ~ 570 cm-1 does not arise from the vibration of the interstitial oxygen O_δ in the Hg/Tl-O plane, but from the frequency-shift of the A_1g-type vibration of the apical oxygen O_A. The peak at 570 cm-1 is from the O_As surrounded by the O_δs in the nearest neighbor, while the 590 cm-1 mode is from the O_As without the O_δs in the immediate neighbor. The intensity of the 570 cm-1 mode increases with the O_δ content, but the Raman frequencies of both modes do not change significantly. This suggests that the increase of the frequency of the OA A_1g mode under high pressure (I.-S. Yang et al., Phys. Rev. B 51, 644 (1995)) is independent from the O_δ content, in the Hg-based superconductors.

Principles for Aircraft Energy Mapping

OpenAIRE

Berg, Frederick T N

2013-01-01

An increasing emphasis on energy eciency in aircraft systems has in recentyears led to greater interest in integrated design and optimisation withinthe industry. New tools are needed to understand, compare and manage energyuse of an aircraft throughout its design and operation. This thesis describes a new methodology to meet this need: aircraft exergy mapping.The choice of exergy, a 2nd law metric, to describe the energy ows is fundamental to the methodology, providing numerous advantages ove...

Implementation of Enhanced Attenuation at the DOE Mound Site OU-1 Landfill: Accelerating Progress and Reducing Costs

Energy Technology Data Exchange (ETDEWEB)

Hooten, Gwendolyn [U.S. Department of Energy, Office of Legacy Management; Cato, Rebecca [Navarro Research and Engineering; Looney, Brian [Savannah River National Laboratory, Aiken, SC

2016-03-06

At the US Department of Energy (DOE), Office of Legacy Management, Mound, Ohio, Site, chlorinated organic contaminants (cVOCs) originating from the former solid-waste landfill have impacted groundwater in Operable Unit 1 (OU-1). The baseline groundwater remedy was groundwater pump and treat (P&T). Since the source materials have been removed from the landfill, the Mound core team, which consists of DOE, US Environmental Protection Agency (US EPA), Ohio EPA, and other stakeholders, is assessing the feasibility of switching from the active P&T remedy to a passive attenuation-based remedy. Toward this end, an enhanced attenuation (EA) strategy based on the creation of structured geochemical zones was developed. This EA strategy addresses the residual areas of elevated cVOCs in soil and groundwater while minimizing the rebound of groundwater concentrations above regulatory targets (e.g., maximum contaminant levels [MCLs]) and avoiding plume expansion while the P&T system is turned off. The EA strategy has improved confidence and reduced risk on the OU-1 groundwater transition path to monitored natural attenuation (MNA). To better evaluate the EA strategy, DOE is conducting a field demonstration to evaluate the use of edible oils to enhance the natural attenuation processes. The field demonstration is designed to determine whether structured geochemical zones can be established that expedite the attenuation of cVOCs in the OU-1 groundwater. The EA approach at OU-1 was designed based on “structured geochemical zones” and relies on groundwater flow through a succession of anaerobic and aerobic zones. The anaerobic zones stimulate relatively rapid degradation of the original solvent source compounds (e.g., cVOCs such as tetrachloroethene [PCE] and trichloroethene [TCE]). The surrounding aerobic areas encourage relatively rapid degradation of daughter products (such as dichloroethene [DCE] and vinyl chloride [VC]) as well as enhanced cometabolism of TCE resulting from

Composite materials for aircraft structures

National Research Council Canada - National Science Library

Baker, A. A; Dutton, Stuart; Kelly, Donald

2004-01-01

... materials for aircraft structures / Alan Baker, Stuart Dutton, and Donald Kelly- 2nd ed. p. cm. - (Education series) Rev. ed. of: Composite materials for aircraft structures / edited by B. C. Hos...

Bespilotne letelice zapadnih zemalja / Unmanned aircraft of Western countries

Directory of Open Access Journals (Sweden)

Slavko Pokorni

2002-11-01

Full Text Available Trend sve češće primene bespilotnih letelica biće nastavljen nesumnjivo, i tokom ove decenije. U vezi s tim stiče se utisak da će razvoj borbenih bespilotnih letilica biti u usponu. Mada je u proteklom periodu težište bilo na razvoju bespilotnih letilica za vojne primene (gde su ulagana velika sredstva, a civilni sektor je, uglavnom, koristio rezultate razvoja vojnih bespilotnih letelica, u narednom periodu se očekuje porast ulaganja i u razvoj bespilotnih letelica u civilnom sektoru. Bespilotne letelice su imale značajnu ulogu u zadacima koje su obavljale multinacionalne snage u toku rata u Bosni i Hercegovini i agresije NATO-a na SRJ, pa je poznavanje karakteristika bespilotnih letelica, za pripadnike Vojske, od velikog značaja. U sažetom tabelarnom pregledu prikazani su podatci o bespilotnim letelicama uglavnom proizvođača iz zapadnih zemalja, što ne znači da ih ne proizvode i druge zemlje, posebno Ruska federacija kao i neke susedne zemlje (Bugarska, Hrvatska. / The increasingly frequent use of unmanned aircraft will continue unabated throughout this decade. About that the impression is that the development of combat drones will rise. Although in the past period the focus was on the development of unmanned military vehicles (where large funds were invested, and the civil sector used mainly the development of military drones, in the coming period, investment in the development of unmanned aircraft in the civil sector is expected . Unmanned aircraft played a significant role in the tasks performed by multinational forces during the war in Bosnia and Herzegovina and NATO aggression in the FR Yugoslavia, so the knowledge of the characteristics of drones for members of the Army is of great importance. The summary table shows the data on unmanned aircraft mainly manufactured from Western countries, which does not mean that they are not produced by other countries, especially the Russian Federation as well as some neighboring

31 CFR 560.528 - Aircraft safety.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on a... the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft. ...

26 CFR 1.167(g)-1 - Basis for depreciation.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Basis for depreciation. 1.167(g)-1 Section 1.167... for depreciation. The basis upon which the allowance for depreciation is to be computed with respect... property at that time, is the basis for computing depreciation. [T.D. 6500, 25 FR 11402, Nov. 26, 1960...

Structure of the (0+,1+) mesons Bs0 and Bs1, and the strong coupling constant gBs0BK and gBs1B*K

International Nuclear Information System (INIS)

Wang, Z. G.

2008-01-01

In this article, we take the point of view that the bottomed (0 + ,1 + ) mesons B s0 and B s1 are the conventional bs meson and calculate the strong coupling constants g B s0 BK and g B s1 B*K with the light-cone QCD sum rules. The numerical values of strong coupling constants g B s1 B*K and g B s0 BK are very large and support the hadronic dressing mechanism. Just like the scalar mesons f 0 (980), a 0 (980), D s0 and axial-vector meson D s1 , the (0 + ,1 + ) bottomed mesons B s0 and B s1 may have small bs kernels of the typical bs meson size. The strong couplings to the hadronic channels (or the virtual mesons loops) may result in smaller masses than the conventional bs mesons in the potential quark models and enrich the pure bs states with other components.

Bundes-Immissionsschutzgesetz (Federal Nuisance Protection Act). BImSchG, BImSch-Verordnungen, EMASPrivilegV, Biokraft-NachV, TA Luft, TA Laerm, USchadG, TEHG, ZuG 2012, ZuV 2012, EHVV 2012, FlugISchG, 2. FlugLSV. 29. ed.; Bundes-Immissionsschutzgesetz. BImSchG, BImSch-Verordnungen, EMASPrivilegV, Biokraft-NachV, TA Luft, TA Laerm, USchadG, TEHG, ZuG 2012, ZuV 2012, EHVV 2012, FlugISchG, 2. FlugLSV

Energy Technology Data Exchange (ETDEWEB)

Hansmann, Klaus (ed.)

2011-07-01

After a detailed introduction, the book goes into detail about the specifications of the Federal Immission Control Act (BImSchG). Also discussed are all regulations for the implementation of the BImSchG, the EMAS-Privilegierungsverordnung (privileges ordinance), the biofuels sustainibility ordinance (Biokraft-NachV), the Technical Instructions on Air Quality Control (TA Luft) and the Technical Instructions on Noise Control (TA Laerm), the Environmental Damage Act (Umweltschadensgesetz), the Greenhouse Gas Emissions Act (Treibhausgas-Emissionshandelsgesetz), the Allocation Act (Zuteilungsgesetz 2012), the Allocation Ordinance (Zuteilungsverordnung 2012), the Auctioning Ordinance (Emissionshandels-Versteigerungsverordnung 2012), and the Aircraft Noise Act (Gesetz zum Schutz gegen Fluglaerm) and the Ordinance on Noise Protection in Airports (Flugplatz-Schallschutzmassnahmenverordnung).

UNMANNED AIRCRAFT SYSTEMS FOR RAPID NEAR SURFACE GEOPHYSICAL MEASUREMENTS

Directory of Open Access Journals (Sweden)

J. B. Stoll

2013-08-01

Full Text Available This paper looks at some of the unmanned aircraft systems (UAS options and deals with a magnetometer sensor system which might be of interest in conducting rapid near surface geophysical measurements. Few of the traditional airborne geophysical sensors are now capable of being miniaturized to sizes and payload within mini UAS limits (e.g. airborne magnetics, gamma ray spectrometer. Here the deployment of a fluxgate magnetometer mounted on an UAS is presented demonstrating its capability of detecting metallic materials that are buried in the soil. The effectiveness in finding ferrous objects (e.g. UXO, landslides is demonstrated in two case studies.

Aircraft impact on nuclear power plants concrete structures

International Nuclear Information System (INIS)

Coombs, R.F.; Barbosa, L.C.B.; Santos, S.H.C.

1980-01-01

A summary about the procedures for the analysis of aircraft on concrete structures, aiming to emphasize the aspects related to the nuclear power plants safety, is presented. The impact force is determined by the Riera model. The effect of this impact force on the concrete structures is presented, showing the advantages to use nonlinear behaviour in the concrete submitted to short loads. The simplifications used are shown through a verification example of the nuclear reactor concrete shielding. (E.G.) [pt

Alternate Fuels for Use in Commercial Aircraft

Science.gov (United States)

Daggett, David L.; Hendricks, Robert C.; Walther, Rainer; Corporan, Edwin

2008-01-01

The engine and aircraft Research and Development (R&D) communities have been investigating alternative fueling in near-term, midterm, and far-term aircraft. A drop in jet fuel replacement, consisting of a kerosene (Jet-A) and synthetic fuel blend, will be possible for use in existing and near-term aircraft. Future midterm aircraft may use a biojet and synthetic fuel blend in ultra-efficient airplane designs. Future far-term engines and aircraft in 50-plus years may be specifically designed to use a low- or zero-carbon fuel. Synthetic jet fuels from coal, natural gas, or other hydrocarbon feedstocks are very similar in performance to conventional jet fuel, yet the additional CO2 produced during the manufacturing needs to be permanently sequestered. Biojet fuels need to be developed specifically for jet aircraft without displacing food production. Envisioned as midterm aircraft fuel, if the performance and cost liabilities can be overcome, biofuel blends with synthetic jet or Jet-A fuels have near-term potential in terms of global climatic concerns. Long-term solutions address dramatic emissions reductions through use of alternate aircraft fuels such as liquid hydrogen or liquid methane. Either of these new aircraft fuels will require an enormous change in infrastructure and thus engine and airplane design. Life-cycle environmental questions need to be addressed.

Using an Optionally Piloted Aircraft for Airborne Gravity Observations with the NOAA GRAV-D Project

Science.gov (United States)

Youngman, M.; Johnson, J. A.; van Westrum, D.; Damiani, T.

2017-12-01

The U.S. National Geodetic Survey's (NGS) Gravity for the Redefintion of the American Vertical Datum (GRAV-D) project is collecting airborne gravity data to support a 1 cm geoid. Started in 2008, this project will collect airborne gravity data over the entire U.S. and territories by 2022. As of June 30, 2017, the project was almost 62% complete. With recent technological developments, NGS has been exploring using unmanned aircraft for airborne gravity measurements. This presentation will focus on results from two surveys over the U.S. Appalachian and Rocky Mountains using the Aurora Centaur Optionally Piloted Aircraft and the Micro-g Lacoste Turnkey Airborne Gravimeter System 7 (TAGS7). Collecting high quality data as well as dealing with remote locations has been a challenge for the GRAV-D project and the field of airborne gravity in general. Unmanned aircraft could potentially improve data quality, handle hard to reach locations, and reduce pilot fatigue. The optionally piloted Centaur aircraft is an attractive option because it is not restricted in U.S. airspace and delivers high quality gravity data. Specifically, the Centaur meets U.S. Federal Aviation Administration regulations for Unmanned Aircraft Systems (UAS) by using a safety pilot on board to maintain line of sight and the ability to take control in the event of an emergency. Even though this is a sizeable UAS, most traditional gravimeters are too large and heavy for the platform. With a smaller and lighter design, the TAGS7 was used for its ability to conform to the aircraft's size restrictions, with the added benefit of upgraded performance capabilities. Two surveys were performed with this aircraft and gravimeter, one in April and one in August to September of 2017. Initial results indicate that the high-gain, fast response of the Centaur autopilot (optimized for flights without passengers), coupled with the full-force feedback sensor of the TAGS7, provides superior performance in all conditions, and

Analysis of the G1 arrest position of senescent WI38 cells by quinacrine dihydrochloride nuclear fluorescence: evidence for a late G1 arrest

International Nuclear Information System (INIS)

Gorman, S.D.; Cristofalo, V.J.

1986-01-01

Senescence of the human diploid fibroblast-like cell line, W138, is characterized by a loss of proliferative activity and an arrest of cells with a 2C DNA content (G1 or G0). To examine the specific region within G1 in which senescent cells arrest, senescent cells were stained with quinacrine dihydrochloride (QDH) and their nuclear fluorescence was compared with that of young cultures arrested in early and late G1 by serum deprivation and hydroxyurea exposure, respectively. Release of these G1-arrested young cultures from their blocking conditions and timing the kinetics of their entry into the S phase by autoradiographic detection of [ 3 H]thymidine incorporation revealed that serum-deprived cells entered the S phase within 15-18h, whereas hydroxyurea-exposed cells entered the S phase within 1.5h, thus confirming their relative G1-arrest positions. QDH-stained, serum-deprived and hydroxyurea-exposed young cells exhibited relative nuclear fluorescence intensities of 51.7 and 23.9, respectively. Senescent cells exhibited a relative nuclear fluorescence intensity of 17.4, closely resembling the fluorescence of young cultures arrested in late G1 by hydroxyurea exposure. These data support the concept that senescent cells are arrested from further progression in the cell cycle in late G1

Hazards from aircraft

International Nuclear Information System (INIS)

Grund, J.E.; Hornyik, K.

1975-01-01

The siting of nuclear power plants has created innumerable environmental concerns. Among the effects of the ''man-made environment'' one of increasing importance in recent nuclear plant siting hazards analysis has been the concern about aircraft hazards to the nuclear plant. These hazards are of concern because of the possibility that an aircraft may have a malfunction and crash either near the plant or directly into it. Such a crash could be postulated to result, because of missile and/or fire effects, in radioactive releases which would endanger the public health and safety. The majority of studies related to hazards from air traffic have been concerned with the determination of the probability associated with an aircraft striking vulnerable portions of a given plant. Other studies have focused on the structural response to such a strike. This work focuses on the problem of strike probability. 13 references

Aircraft Carriers

DEFF Research Database (Denmark)

Nødskov, Kim; Kværnø, Ole

as their purchases of aircraft carrier systems, makes it more than likely that the country is preparing such an acquisition. China has territorial disputes in the South China Sea over the Spratly Islands and is also worried about the security of its sea lines of communications, by which China transports the majority......, submarines, aircraft and helicopters, is not likely to be fully operational and war-capable until 2020, given the fact that China is starting from a clean sheet of paper. The United States of America (USA), the United Kingdom (UK), Russia and India are currently building or have made decisions to build new...

The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis

Science.gov (United States)

Živković, Maja; Starčević Čizmarević, Nada; Lovrečić, Luca; Klupka-Sarić, Inge; Stanković, Aleksandra; Gašparović, Iva; Dinčić, Evica; Stojković, Ljiljana; Rudolf, Gorazd; Šega Jazbec, Saša; Perković, Olivio; Sinanović, Osman; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut

2014-01-01

Background. Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS). Methods. The GENoMS includes four populations (Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian) sharing the same geographic location and a similar ethnic background. A total of 885 patients and 656 ethnically matched healthy blood donors with no history of MS in their families were genotyped using PCR-RFLP. Results. TPA DD homozygosity was protective (OR = 0.79, 95% CI 0.63–0.99, P = 0.037) and PAI 5G5G was a risk factor for MS (OR = 1.30, 95% CI 1.01–1.66, P = 0.038). A significant effect of the genotype/carrier combination was detected in 5G5G/I carriers (OR = 1.39 95% CI 1.06–1.82, P = 0.017). Conclusions. We found a significantly harmful effect of the combination of the PAI-1 5G/5G genotype and TPA I allele on MS susceptibility, which indicates the importance of gene-gene interactions in complex diseases such as MS. PMID:24825926

Perspectives on Highly Adaptive or Morphing Aircraft

Science.gov (United States)

McGowan, Anna-Maria R.; Vicroy, Dan D.; Busan, Ronald C.; Hahn, Andrew S.

2009-01-01

The ability to adapt to different flight conditions has been fundamental to aircraft design since the Wright Brothers first flight. Over a hundred years later, unconventional aircraft adaptability, often called aircraft morphing has become a topic of considerable renewed interest. In the past two decades, this interest has been largely fuelled by advancements in multi-functional or smart materials and structures. However, highly adaptive or morphing aircraft is certainly a cross-discipline challenge that stimulates a wide range of design possibilities. This paper will review some of the history of morphing aircraft including recent research programs and discuss some perspectives on this work.

Small Transport Aircraft Technology /STAT/ Propulsion Study

Science.gov (United States)

Heldenbrand, R. W.; Baerst, C. F.; Rowse, J. H.

1980-01-01

The NASA Small Transport Aircraft Technology (STAT) Propulsion Study was established to identify technology requirements and define the research and development required for new commuter aircraft. Interim results of the studies defined mission and design characteristics for 30- and 50-passenger aircraft. Sensitivities were defined that relate changes in engine specific fuel consumption (SFC), weight, and cost (including maintenance) to changes in the aircraft direct operating cost (DOC), takeoff gross weight, and empty weight. A comparison of performance and economic characteristics is presented between aircraft powered by 1980 production engines and those powered by a 1990 advanced technology baseline engine.

Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells.

Science.gov (United States)

Hashimoto, Takashi; He, Zhiwei; Ma, Wei-Ya; Schmid, Patricia C; Bode, Ann M; Yang, Chung S; Dong, Zigang

2004-05-01

Caffeine is a major biologically active constituent in coffee and tea. Because caffeine has been reported to inhibit carcinogenesis in UVB-exposed mice, the cancer-preventing effect of caffeine has attracted considerable attention. In the present study, the effect of caffeine in quiescent (G0 phase) cells was investigated. Pretreatment with caffeine suppressed cell proliferation in a dose-dependent manner 36 h after addition of fetal bovine serum as a cell growth stimulator. Analysis by flow cytometry showed that caffeine suppressed cell cycle progression at the G0/G1 phase, i.e., 18 h after addition of fetal bovine serum, the percentages of cells in G0/G1 phase in 1 mM caffeine-treated cells and in caffeine-untreated cells were 61.7 and 29.0, respectively. The percentage of cells in G0/G1 phase at 0 h was 75.5. Caffeine inhibited phosphorylation of retinoblastoma protein at Ser780 and Ser807/Ser811, the sites where retinoblastoma protein has been reported to be phosphorylated by cyclin-dependent kinase 4 (cdk4). Furthermore, caffeine inhibited the activation of the cyclin D1-cdk4 complex in a dose-dependent manner. However this compound did not directly inhibit the activity of this complex. In addition, caffeine did not affect p16INK4 or p27Kip1 protein levels, but inhibited the phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3beta. Our results showed that caffeine suppressed the progression of quiescent cells into the cell cycle. The inhibitory mechanism may be due to the inhibition of cell growth signal-induced activation of cdk4, which may be involved in the inhibition of carcinogenesis in vivo.

Measurements of reactivity of reactor G1; Mesures de reactivite sur reacteur G1

Energy Technology Data Exchange (ETDEWEB)

Bernot, J; Koechlin, J C; Portes, L; Teste du Bailler, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

The various methods used during the physical study of the reactor G1 to determine the variations of the effective multiplication factor consecutive to a given change in the geometry of the multiplying medium, are presented and discussed. The comparison of the results obtained by these various methods has allowed their validity to be tested and precise conditions of use to be given. In the first part are presented the principles used and their ranges of validity. In the second part the experimental results are given, together with some indications on their comparison with theoretical estimations. (author) [French] Nous exposons et discutons diverses methodes utilisees, lors de l'etude physique du reacteur G1, pour determiner les variations du facteur de multiplication effectif consecutives a un changement donne dans la geometrie du milieu multiplicateur. La comparaison des resultats obtenus par diverses methodes nous a permis de tester leur validite et d'en preciser les conditions d'emploi. Dans une premiere partie, nous exposons les principes utilises et leurs domaines de validite. Dans une seconde partie nous donnons les resultats experimentaux obtenus avec quelques indications sur leur comparaison avec les estimations theoriques. (auteur)

USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process. Volume 1

National Research Council Canada - National Science Library

Adamson, Anthony

1998-01-01

.... It is published as three separate volumes. Volume I, USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process -- Phase II Report, discusses the result and cost/benefit analysis of testing three initiatives...

Daedalus Project's Light Eagle - Human powered aircraft

Science.gov (United States)

1987-01-01

The Michelob Light Eagle is seen here in flight over Rogers Dry Lake at the NASA Dryden Flight Research Center, Edwards, California. The Light Eagle and Daedalus human powered aircraft were testbeds for flight research conducted at Dryden between January 1987 and March 1988. These unique aircraft were designed and constructed by a group of students, professors, and alumni of the Massachusetts Institute of Technology within the context of the Daedalus project. The construction of the Light Eagle and Daedalus aircraft was funded primarily by the Anheuser Busch and United Technologies Corporations, respectively, with additional support from the Smithsonian Air and Space Museum, MIT, and a number of other sponsors. To celebrate the Greek myth of Daedalus, the man who constructed wings of wax and feathers to escape King Minos, the Daedalus project began with the goal of designing, building and testing a human-powered aircraft that could fly the mythical distance, 115 km. To achieve this goal, three aircraft were constructed. The Light Eagle was the prototype aircraft, weighing 92 pounds. On January 22, 1987, it set a closed course distance record of 59 km, which still stands. Also in January of 1987, the Light Eagle was powered by Lois McCallin to set the straight distance, the distance around a closed circuit, and the duration world records for the female division in human powered vehicles. Following this success, two more aircraft were built, the Daedalus 87 and Daedalus 88. Each aircraft weighed approximately 69 pounds. The Daedalus 88 aircraft was the ship that flew the 199 km from the Iraklion Air Force Base on Crete in the Mediterranean Sea, to the island of Santorini in 3 hours, 54 minutes. In the process, the aircraft set new records in distance and endurance for a human powered aircraft. The specific areas of flight research conducted at Dryden included characterizing the rigid body and flexible dynamics of the Light Eagle, investigating sensors for an

The -675 4G/5G polymorphism in the PAI-1 gene may not contribute to the risk of PCOS.

Science.gov (United States)

Zhang, T-T; Yuan, L; Yang, Y-M; Ren, Y

2014-08-01

The association between the -675 4G/5G polymorphism in PAI-1 gene and PCOS has been studied with inconclusive results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on the polymorphism. Searches were performed in the PubMed, Embase, CNKI and Wanfang databases, covering all papers. Statistical analysis was performed using Revman5.2 and STATA11.0 software. A total of 11 case-control studies were extracted on the polymorphism involving 1861 PCOS cases and 1187 controls. The results showed that, no significant increased/decreased risk were found for the polymorphism for PCOS: OR = 1.03, 95% CI = 0.77-1.66, p = 0.52 for 4G4G + 4G5G vs. 5G5G; OR = 0.99, 95% CI = 0.66-1.49, p = 0.96 for 4G4G vs. 5G5G + 4G5G; OR = 1.08, 95% CI = 0.66-1.79, p = 0.76 for 4G4G vs. 5G5G; OR = 1.11, 95% CI = 0.78-1.58, p = 0.56 for 4G5G vs. 5G5G; OR = 1.00, 95% CI = 0.71-1.41, p = 0.99 for 4G vs. 5G. In the further subgroup analysis by ethnicity, we did not find a significant association between the polymorphism for PCOS risk in either Asians or Europeans. Our findings demonstrated that -675 4G/5G polymorphism in the PAI-1 gene might not be a risk factor for the development of PCOS.

IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome.

Science.gov (United States)

Guhsl, E E; Hofstetter, G; Lengger, N; Hemmer, W; Ebner, C; Fröschl, R; Bublin, M; Lupinek, C; Breiteneder, H; Radauer, C

2015-01-01

Birch pollen-associated plant food allergy is caused by Bet v 1-specific IgE, but presence of cross-reactive IgE to related allergens does not predict food allergy. The role of other immunoglobulin isotypes in the birch pollen-plant food syndrome has not been investigated in detail. Bet v 1-sensitized birch pollen-allergic patients (n = 35) were diagnosed for food allergy by standardized interviews, skin prick tests, prick-to-prick tests and ImmunoCAP. Concentrations of allergen-specific IgE, IgG1, IgG4 and IgA to seven Bet v 1-related food allergens were determined by ELISA. Bet v 1, Cor a 1, Mal d 1 and Pru p 1 bound IgE from all and IgG4 and IgA from the majority of sera. Immunoglobulins to Gly m 4, Vig r 1 and Api g 1.01 were detected in allergy and increased or reduced levels of IgE, IgG1, IgG4 or IgA specific to most Bet v 1-related allergens. Api g 1-specific IgE was significantly (P = 0.01) elevated in celeriac-allergic compared with celeriac-tolerant patients. Likewise, frequencies of IgE (71% vs 15%; P = 0.01) and IgA (86% vs 38%; P = 0.04) binding to Api g 1.01 were increased. Measurements of allergen-specific immunoglobulins are not suitable for diagnosing Bet v 1-mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac. © 2014 The Authors. Allergy Published by John Wiley & Sons Ltd.

Structural design for aircraft impact loading

International Nuclear Information System (INIS)

Schmidt, R.; Heckhausen, H.; Chen, C.; Rieck, P.J.; Lemons, G.W.

1977-01-01

The Soft Shell-Hardcore approach to nuclear power plant auxiliary structure design was developed to attenuate the crash effects of impacting aircraft. This report is an initial investigation into defining the important structural features involved that would allow the Soft Shell-Hardcore design to successfully sustain the postulated aircraft impact. Also specified for purposes of this study are aircraft impact locations and the type and velocity of impacting aircraft. The purpose of this initial investigation is to determine the feasibility of the two 0.5 m thick walls of the Soft Shell with the simplest possible mathematical model

Dynamics of the G-excess illusion

Science.gov (United States)

Baylor, K. A.; Reschke, M.; Guedry, F. E.; Mcgrath, B. J.; Rupert, A. H.

1992-01-01

The G-excess illusion is increasingly recognized as a cause of aviation mishaps especially when pilots perform high-speed, steeply banked turns at low altitudes. Centrifuge studies of this illusion have examined the perception of subject orientation and/or target displacement during maintained hypergravity with the subject's head held stationary. The transient illusory perceptions produced by moving the head in hypergravity are difficult to study onboard centrifuges because the high angular velocity ensures the presence of strong Coriolis cross-coupled semicircular canal effects that mask immediate transient otolith-organ effects. The present study reports perceptions following head movements in hypergravity produced by high-speed aircraft maintaining a banked attitude with low angular velocity to minimize cross-coupled effects. Methods: Fourteen subjects flew on the NASA KC-135 and were exposed to resultant gravity forces of 1.3, 1.5, and 1.8 G for 3 minute periods. On command, seated subjects made controlled head movements in roll, pitch, and yaw at 30 second intervals both in the dark and with faint targets at a distance of 5 feet. Results: head movement produced transient perception of target displacement and velocity at levels as low as 1.3 G. Reports of target velocity without appropriate corresponding displacement were common. At 1.8 G when yaw head movements were made from a face down position, 4 subjects reported oscillatory rotational target displacement with fast and slow alternating components suggestive of torsional nystagmus. Head movements evoked symptoms of nausea in most subjects, with 2 subjects and 1 observer vomiting. Conclusions: The transient percepts present conflicting signals, which introduced confusion in target and subject orientation. Repeated head movements in hypergravity generate nausea by mechanisms distinct from cross-coupled Coriolis effects.

Standard Test Method for Effects of Cleaning and Chemical Maintenance Materials on Painted Aircraft Surfaces