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Sample records for docket nos 50-327

  1. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority. Supplement No. 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-01-01

    On September 17, 1980, the Nuclear Regulatory Commission (NRC) issued the facility operating license DPR-77 to the Tennessee Valley Authority for the Sequoyah Nuclear Plant, Unit 1, located in Hamilton County, Tennessee. The license authorized operation of Unit 1 at 100 percent power; however, a license condition regarding the adequacy of the hydrogen control system was included that required resolution by January 31, 1981. The purpose of Supplement No. 4 to the SER is to further update our Safety Evaluation Reports on the hydrogen control measures (Section 22.2, II.B.7), and to comply with the license condition which is as follows: 'By January 31, 1981, TVA shall by testing and analysis show to the satisfaction of the NRC staff that an interim hydrogen control system will provide with reasonable assurance protection against breach of containment in the event that a substantial quantity of hydrogen is generated.' TVA submitted on December 11, 1980, the first quarterly report on the research program for hydrogen control. Also, TVA revised volume 2 of the Sequoyah Core Degradation Program Report to incorporate additional information on the overall program. Section II.B.7 of Supplement No. 4 responds to the license condition. Each section is supplementary to and not in lieu of discussion in the Safety Evaluation Report and Supplements Nos. 1, 2, and 3, except where specifically noted. Supplements No. 2 and 3 to the Safety Evaluation Report provided a basis for concluding that the full-power licensing of Sequoyah Unit 1 need not await completion of ongoing work on hydrogen control measures. This supplement concludes that operation of the IDIS for an interim period of one year is appropriate.

  2. Safety evaluation report related to operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket nos. 50-327 and 50-328, Tennessee Valley Authority

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-03-01

    A safety evaluation of the Tennessee Valley Authority's application for a license to operate its Sequoyah Nuclear Plant, Units 1 and 2, located in Hamilton County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. It consists of a technical review and staff evaluation of applicant information on: (1) population density, land use, and physical characteristics of the site area; (2) design, fabrication, construction, testing criteria, and performance characteristics of plant structures, systems, and components important to safety; (3) expected response of the facility to anticipated operating transients, and to postulated design basis accidents; (4) applicant engineering and construction organization, and plans for the conduct of plant operations; and (5) design criteria for a system to control the plant's radiological effluents. The staff has concluded that the plant can be operated by the Tennessee Valley Authority without endangering the health and safety of the public provided that the outstanding matters discussed in the report are favorably resolved. (author)

  3. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority

    International Nuclear Information System (INIS)

    1982-12-01

    Supplement No. 6 to the Safety Evaluation Report (SER) related to the operation of the Tennessee Valley Authority's Sequoyah Nuclear Plant, Units 1 and 2, located in Hamilton County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The purpose of this supplement is to update the staff's evaluations of the issues related to the hydrogen mitigation system identified in the SER and previous supplements as needing resolution

  4. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority. Supplement No. 3

    International Nuclear Information System (INIS)

    1980-09-01

    It was stated in Supplement No. 2 to the Safety Evaluation Report that except for the hydrogen control measures for the Sequoyah units, all matters had been resolved to the extent that the activities authorized by the license can be conducted without endangering the health and safety of the public. The staff is presently reviewing a recent report from TVA entitled 'Report on the Safety Evaluation of the Interim Distributed Ignition System' (Volume 1 and 2) dated September 2, 1980. This supplement provides further information and reviews on the hydrogen issue. Pending further action which may be required as a result of rulemaking, but no later than January 31, 1981, TVA shall by testing and analysis show to the NRC's satisfaction that the interim distributed ignition system will function in a manner that will mitigate the risk which could stem from the generation of hydrogen

  5. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority. Supplement No. 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1980-09-01

    It was stated in Supplement No. 2 to the Safety Evaluation Report that except for the hydrogen control measures for the Sequoyah units, all matters had been resolved to the extent that the activities authorized by the license can be conducted without endangering the health and safety of the public. The staff is presently reviewing a recent report from TVA entitled 'Report on the Safety Evaluation of the Interim Distributed Ignition System' (Volume 1 and 2) dated September 2, 1980. This supplement provides further information and reviews on the hydrogen issue. Pending further action which may be required as a result of rulemaking, but no later than January 31, 1981, TVA shall by testing and analysis show to the NRC's satisfaction that the interim distributed ignition system will function in a manner that will mitigate the risk which could stem from the generation of hydrogen.

  6. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority. Supplement No. 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1980-08-01

    The purpose of this supplement is to further update the Safety Evaluation Report by providing (1) our evaluation of additional information submitted by the licensee since the issuance of Supplement No. 1 to the Safety Evaluation Report, (2) our evaluation and status of the Non-TMI-2 outstanding issues identified in Part I of SER Supplement No. 1, (3) our evaluation of TMI-2 requirements which must be completed prior to the issuance of a full-power operating license, (4) our evaluation of dated requirements which the licensee must implement by the dates identified in NUREG-0694, TMI-Related Requirements for New Operating Licenses, and (5) our evaluation of additional information for those sections of the Safety Evaluation Report where further discussion or changes are in order.

  7. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority. Supplement No. 2

    International Nuclear Information System (INIS)

    1980-08-01

    The purpose of this supplement is to further update the Safety Evaluation Report by providing (1) our evaluation of additional information submitted by the licensee since the issuance of Supplement No. 1 to the Safety Evaluation Report, (2) our evaluation and status of the Non-TMI-2 outstanding issues identified in Part I of SER Supplement No. 1, (3) our evaluation of TMI-2 requirements which must be completed prior to the issuance of a full-power operating license, (4) our evaluation of dated requirements which the licensee must implement by the dates identified in NUREG-0694, TMI-Related Requirements for New Operating Licenses, and (5) our evaluation of additional information for those sections of the Safety Evaluation Report where further discussion or changes are in order

  8. 76 FR 54259 - Virginia Electric and Power Company, Docket Nos. 50-338 and 50-339, North Anna Power Station...

    Science.gov (United States)

    2011-08-31

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0185] Virginia Electric and Power Company, Docket Nos. 50.... NPF-4 and NPF-7, issued to Virginia Electric Power Company (the licensee), for operation of the North...) and (d) during declarations of severe weather conditions involving tropical storm or hurricane force...

  9. Safety Evaluation Report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323)

    International Nuclear Information System (INIS)

    1991-06-01

    Supplement 34 to the Safety Evaluation Report for the application by Pacific Gas and Electric Company (PG ampersand E) for licenses to operate Diablo Canyon Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-275 and 50-323, respectively) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement documents the NRC staff review of the Long-Term Seismic Program conducted by PG ampersand E in response to License Condition 2.C.(7) of Facility Operating License DPR-80, the Diablo Canyon Unit 1 operating license. 111 refs., 20 figs., 31 tabs

  10. Safety evaluation report related to the operation of Midland Plant, Units 1 and 2. Docket Nos. 50-329 and 50-330. Consumers Power Company

    International Nuclear Information System (INIS)

    1982-06-01

    This report supplements the Safety Evaluation Report, NUREG-0793, issued with respect to the application filed for licenses to operate the Midland Plant, Units 1 and 2 (Docket Nos. 50-329 and 50-330). This supplement provides recent information regarding resolution of some of the open items identified in the Safety Evaluation Report and discusses recommendations of the Advisory Committee on Reactor Safeguards in its interim report dated June 8, 1982

  11. Safety Evaluation Report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323)

    International Nuclear Information System (INIS)

    1984-02-01

    Supplement 17 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plants, Units 1 and 2 (Docket Nos. 50-275 and 50-323) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and the previous supplements

  12. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 14

    Energy Technology Data Exchange (ETDEWEB)

    Tam, P.S.

    1994-12-01

    Supplement No. 14 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation with additional information submitted by the applicant since Supplement No. 13 was issued, and matters that the staff had under review when Supplement No. 13 was issued.

  13. Safety Evaluation Report related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457)

    International Nuclear Information System (INIS)

    1987-05-01

    In November 1983, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1002) regarding the application filed by the Commonwealth Edison Company, as applicant and owner, for a license to operate Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457). The first supplement to NUREG-1002 was issued in September 1986; the second supplement to NUREG-1002 was issued in October 1986. This third supplement to NUREG-1002 reports the status of certain items that remained unresolved at the time Supplement 2 was published. The facility is located in Reed Township, Will County, Illinois

  14. Safety evaluation report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352-50-353). Supplement 1

    International Nuclear Information System (INIS)

    1983-12-01

    This report supplements the Safety Evaluation Report (NUREG-0991, August 1983) for the application filed by the Philadelphia Electric Company, as applicant and owner, for licenses to operate the Limerick Generating Station Units 1 and 2 (Docket Nos. 50-352 and 50-353). The facility is located near Pottstown, Pennsylvania. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  15. Safety evaluation report related to the operation of Midland Plant, Units 1 and 2. Docket Nos. 50-329 and 50-330, Consumers Power Company

    International Nuclear Information System (INIS)

    1982-05-01

    The Safety Evaluation Report for the application filed by the Consumers Power Company, as applicant and owner, for a license to operate the Midland Plant Units 1 and 2 (Docket Nos. 50-329 and 50-330), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near the city of Midland in Midland County, Michigan. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  16. Safety evaluation report related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457)

    International Nuclear Information System (INIS)

    1983-11-01

    The Safety Evaluation Report for the application filed by the Commonwealth Edison Company, as applicant and owner, for a license to operate Braidwood Station, Units 1 and 2 (Docket Nos. STN 50-456 and STN 50-457), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Reed Township, Will County, Illinois. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  17. Safety Evaluation Report related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457). Supplement No. 2

    International Nuclear Information System (INIS)

    1986-10-01

    In November 1983, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1002) regarding the application filed by the Commonwealth Edison Company, as applicant and owner, for a license to operate Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457). The first supplement to NUREG-1002 was issued in September 1986. This second supplement to NUREG-1002 reports the status of certain items that remained unresolved at the time Supplement 1 was published. The facility is located in Reed Township, Will County, Illinois

  18. Safety evaluation report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323)

    International Nuclear Information System (INIS)

    1984-06-01

    Supplement 23 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plants, Units 1 and 2 (Docket Nos. 50-275 and 50-323) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement addresses the applicant's requests for approval of 22 deviations from the requirements of Section III.G of Appendix R of Title 10 of the Code of Federal Regulations Part 50

  19. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391): Supplement No. 19

    International Nuclear Information System (INIS)

    1995-11-01

    Supplement No. 19 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation with (1) additional information submitted by the applicant since Supplement No. 18 was issued, and (2) matters that the staff had under review when Supplement No. 18 was issued

  20. Safety-evaluation report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353)

    International Nuclear Information System (INIS)

    1983-08-01

    The Safety Evaluation Report for the application filed by the Philadelphia Electric Company, as applicant and owner, for licenses to operate the Limerick Generating Station Units 1 and 2 (Docket Nos. 50-352 and 50-353), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near Pottstown, Pennsylvania. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  1. Safety Evaluation Report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1987-03-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and the City of Dalton, Georgia, for licenses to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). This sixth supplement of NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved at the time the Safety Evaluation Report was issued. These areas are performance testing, reactor cooling hydraulics, loose parts monitoring, and electric power systems

  2. Safety Evaluation Report related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). Supplement No. 1

    International Nuclear Information System (INIS)

    1986-09-01

    In April 1986 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0781) regarding the application of Houston Lighting and Power Company (applicant and agent for the owners) for a license to operate South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). The facility is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. This first supplement to NUREG-0781 reports the status of certain items that remained unresolved at the time the Safety Evaluation Report was published

  3. Safety evaluation report related to the operation of Shearon Harris Nuclear Power Plant, Units 1 and 2. Docket Nos. STN 50-400 and STN 50-401

    International Nuclear Information System (INIS)

    1983-11-01

    The Safety Evaluation Report for the application filed by the Carolina Power and Light Company, as applicant and owner, for licenses to operate the Shearon Harris Nuclear Power Plant Units 1 and 2 (Docket Nos. 50-400 and 50-401) has been prepared by the Office of Nuclear Reactor Regulation of US Nuclear Regulatory Commission. The facility is located near Raleigh, North Carolina. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  4. Safety Evaluation Report related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457). Supplement No. 1

    International Nuclear Information System (INIS)

    1986-09-01

    In November 1983 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1002) regarding the application filed by the Commonwealth Edison Company, as applicant and owner, for a license to operate Braidwood Station, Units 1 and 2 (Docket Nos. STN 50-456 and STN 50-457). The facility is located in Reed Township, Will County, Illinois. This first supplement to NUREG-1002 reports the status of certain items that remained unresolved at the time the Safety Evaluation Report was published

  5. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391

    International Nuclear Information System (INIS)

    1992-01-01

    Supplement No. 8 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation of (1) additional information submitted by the applicant since Supplement No. 7 was issued, and (2) matters that the staff had under review when Supplement No. 7 was issued

  6. Safety Evaluation Report related to the operation of Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441). Supplement No. 6

    International Nuclear Information System (INIS)

    1985-04-01

    Supplement No. 6 to the Safety Evaluation Report (NUREG-0887) on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-540 and 50-441), has been prepared by the Office of the Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio, approximately 35 miles northeast of Cleveland, Ohio. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1 through 5 to that report

  7. Safety evaluation report related to the operation of Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441). Supplement No. 10

    International Nuclear Information System (INIS)

    1986-09-01

    Supplement No. 10 to the Safety Evaluation Report (NUREG-0887) on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio, approximately 35 miles northeast of Cleveland, Ohio. This supplement reports the status of certain issues and action items that had not been resolved or completed at the time of publication of the Safety Evaluation Report and Supplements Nos. 1 through 9 to that report

  8. Safety Evaluation Report related to the operation of Perry Nuclear Power Plant, Units 1 and 2, (Docket Nos. 50-440 and 50-441)

    International Nuclear Information System (INIS)

    1984-02-01

    Supplement No. 4 to the Safety Evaluation Report on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1, 2 and 3 to that report

  9. Safety Evaluation Report related to the operation of Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441). Supplement No. 8

    International Nuclear Information System (INIS)

    1986-01-01

    Supplement No. 8 to the Safety Evaluation Report (NUREG-0887) on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units and 1 and 2 (Docket Nos. 50-440 and 50-441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio, approximately 35 miles northeast of Cleveland, Ohio. This supplement reports the status of certain issues that has not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1 through 7 to that report

  10. Safety Evaluation Report related to the operation of Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441). Supplement No. 5

    International Nuclear Information System (INIS)

    1985-02-01

    Supplement No. 5 to the Safety Evaluation Report (NUREG-0887) on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, The Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio, approximately 35 miles northeast of Cleveland, Ohio. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1 through 4 to that report

  11. Safety evaluation report related to the operation of Perry Nuclear Power Plant, Units 1 and 2. Docket Nos. 50-440 and 50-441

    International Nuclear Information System (INIS)

    1983-04-01

    Supplement No. 3 to the Safety Evaluation Report on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440/441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1 and 2 to that report

  12. Technical Specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457). Appendix ''A'' to License No. NPF-59

    International Nuclear Information System (INIS)

    1986-10-01

    Information is presented for Braidwood Station Unit Nos. 1 and 2 in the areas of: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  13. Technical specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457): Appendix ''A'' to License No. NPF-70

    International Nuclear Information System (INIS)

    1987-05-01

    The Braidwood Station, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. 18 figs., 55 tabs

  14. Conformance to Regulatory Guide 1.97, Shearon Harris Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-400 and 50-401)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-09-01

    This EG and G Idaho, Inc. report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1 and 2 of the Shearon Harris Nuclear Power Plant and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified. 7 refs

  15. Conformance to Regulatory Guide 1.97, Perry Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-440 and 50-441)

    International Nuclear Information System (INIS)

    Udy, A.C.

    1985-03-01

    This EG and G Idaho, Inc., report provides a review of the submittals for Regulatory Guide 1.97, Revision 2, for the Perry Nuclear Power Plant, Unit Nos. 1 and 2. Any exception to the guidelines of Regulatory Guide 1.97 are evaluated

  16. Conformance to Regulatory Guide 1.97 Slurry Power Station, Unit Nos. 1 and 2 (Docket Nos. 50-280 and 50-281)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-09-01

    This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1 and 2 of the Surry Power Station and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

  17. Safety evaluation report related to the operation of Catawba Nuclear Station, Units 1 and 2. Docket Nos. 50-413 and 50-414. Suppl. 1

    International Nuclear Information System (INIS)

    1983-04-01

    This reort supplements the Safety Evaluation Report (NUREG-0954) issued in February 1983 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Membership Corporation, and Saluda River Electric Cooperative, Inc. as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414, respectively). The facility is located in York County, South Carolina, approximately 9.6 km (6 mi) north of Rock Hill and adjacent to Lake Wylie. This supplement provides more recent information regarding resolution or updating of some of the open and confirmatory items and license conditions identified in the Safety Evaluation Report, and discusses the recommendations of the Advisory Committee on Reactor Safeguards in its report dated March 15, 1983

  18. Safety-evaluation report related to operation of McGuire Nuclear Station, Units 1 and 2. Docket Nos. 50-369 and 50-370

    International Nuclear Information System (INIS)

    1983-05-01

    This report supplements the Safety Evaluation Report Related to the Operation of McGuire Nuclear Station, Units 1 and 2 (SER (NUREG-0422)) issued in March 1978 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Duke Power Company, as applicant and owner, for licenses to operate the McGuire Nuclear Station, Units 1 and 2 (Docket Nos. 50-369 and 50-370). The facility is located in Mecklenburg County, North Carolina, about 17 mi north-northwest of Charlotte, North Carolina. This supplement provides information related to issuance of a full-power authorization for Unit 2. The staff concludes that the McGuire Nuclear Station can be operated by the licensee without endangering the health and safety of the public

  19. Safety evaluation report related to the operation of Seabrook Station, Units 1 and 2. Docket Nos. 50-443 and 50-444. Suppl. 1

    International Nuclear Information System (INIS)

    1983-04-01

    This report supplements the Safety Evaluation Report (NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et. al., for licenses to operate Seabrook Station, Units 1 and 2 (Docket Nos. STN 50-443 and STN 50-444). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  20. Safety Evaluation Report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement No. 1

    International Nuclear Information System (INIS)

    1985-10-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and City of Dalton, Georgia, for a license to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This first supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved at the time the Safety Evaluation Report was issued and provides the Advisory Committee on Reactor Safeguards letter dated August 13, 1985

  1. Safety Evaluation Report related to the operation of Seabrook Station, Units 1 and 2 (Docket Nos. 50-443 and 50-444)

    International Nuclear Information System (INIS)

    1989-05-01

    This report is Supplement No. 8 to the Safety Evaluation Report (SER) (NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et al., for licenses to operate Seabrook Station, Units 1 and 2 (Docket Nos. STN 50-443 and STN 50-444). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public. 2 figs., 1 tab

  2. Safety evaluation report related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499)

    International Nuclear Information System (INIS)

    1987-07-01

    In April 1986 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0781) regarding the application of Houston Lighting and Power Company (applicant and agent for the owners) for a license to operate South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). The facility is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. The first supplement to NUREG-0781 was issued in September 1986, the second supplement in January 1987, and the third supplement in May 1987. This fourth supplement reports on the status of unresolved items in the Safety Evaluation Report and resolves all the issues necessary to support the issuance of a low-power license

  3. Safety evaluation report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323)

    International Nuclear Information System (INIS)

    1983-12-01

    Supplement 20 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plant, Unit 1 and Unit 2 (Docket Nos. 50-275 and 50-323), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports on the verification effort for Diablo Canyon Unit 1 that was performed between November 1981 and the present in response to Commission Order CLI-81-30 and an NRC letter of November 19, 1981 to the licensee. Specifically, Supplement 20 addresses those issues and other matters identified in Supplements 18 and 19 that must be resolved prior to Unit 1 achieving criticality and operating at power levels up to 5% of rated full power. This SER Supplement applies only to Diablo Canyon Unit 1

  4. Safety Evaluation Report related to the operation of Seabrook Station, Units 1 and 2 (Docket Nos. 50-443 and 50-444). Supplement No. 5

    International Nuclear Information System (INIS)

    1986-07-01

    This report is Supplement No. 5 to the Safety Evaluation Report (NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et al., for licenses to operate Seabrook Station, Units 1 and 2 Docket Nos. STN 50-443 and STN 50-444). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  5. Safety evaluation report related to the operation of Perry Nuclear Power Plant, Units 1 and 2: Docket Nos. 50-440 and 50-441

    International Nuclear Information System (INIS)

    1983-01-01

    Supplement No. 2 to the Safety Evaluation Report on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group (CAPCO)), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement No. 1 to that report

  6. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391)

    International Nuclear Information System (INIS)

    Tam, P.S.

    1992-10-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), and Supplement No. 9 (June 1992) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units I and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items, and proposed license conditions identified in the SER

  7. Safety Evaluation Report related to the operation of Cartawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414). Supplement No. 5

    International Nuclear Information System (INIS)

    1986-02-01

    This report supplements the Safety Evaluation Report (NUREG-0954) issued in February 1983 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Membership Corporation, Saluda River Electric Cooperative, Inc., and Piedmont Municipal Power Agency, as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414, respectively). The facility is located in York County, South Carolina, approximately 9.6 km (6 mi) north of Rock Hill and adjacent to Lake Wylie. This supplement provides additional information supporting the license for initial criticality and power ascension to full-power operation for Unit 2

  8. Safety Evaluation Report related to the operation of Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441). Supplement No. 7

    International Nuclear Information System (INIS)

    1985-11-01

    Supplement No. 7 to the Safety Evaluation Report (NUREG-0887) on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket No. 50-440 and 50-441) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio, approximately 35 miles northeast of Cleveland, Ohio. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1 through 6 to that report

  9. Safety evaluation report related to the operation of Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414)

    International Nuclear Information System (INIS)

    1984-07-01

    The report supplements the Safety Evaluation Report (NUREG-0954) issued in February 1983 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Membership Corporation, and Saluda River Electric Cooperative, Inc. as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414, respectively). The facility is located in York County, South Carolina, approximately 9.6 km (6 mi) north of Rock Hill and adjacent to Lake Wylie. This supplement provides additional information supporting the license for fuel loading and precriticality testing for Unit 1

  10. Safety evaluation report related to the operation of Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414)

    International Nuclear Information System (INIS)

    1984-12-01

    This report supplements the Safety Evaluation Report (NUREG-0954) issued in February 1983 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Membership Corporation, and Saluda River Electric Cooperative, Inc., as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414, respectively). The facility is located in York County, South Carolina, approximately 9.6 km (6 mi) north of Rock Hill and adjacent to Lake Wylie. This supplement provides additional information supporting the license for initial criticality and power ascension to full-power opertion for Unit 1

  11. Safety Evaluation Report related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499)

    International Nuclear Information System (INIS)

    1986-04-01

    The Safety Evaluation Report for the application filed by Houston Lighting and Power Company, City Public Service Board of San Antonio, Central Power and Light Company, and the City of Austin, as applicants and owners, for licenses to operate the South Texas Project Units 1 and 2 (Docket Nos. 50-498 and 50-499) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. Subject to resolution of the items discussed in this report, the staff concludes that the applicant can operate the facility without endangering the health and safety of the public

  12. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 4

    International Nuclear Information System (INIS)

    1985-03-01

    This report supplements the Safety Evaluation Report, NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), and Supplement No. 3 (January 1985) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the open and confirmatory items and license conditions identified in the Safety Evaluation Report

  13. Safety evaluation report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425): Supplement 8

    International Nuclear Information System (INIS)

    1989-02-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Corporation, and the City of Dalton, Georgia, for licenses to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement 1 to NUREG-1137 was issued by the Staff in October 1985, Supplement 2 was issued in May 1986, Supplement 3 was issued in August 1986, Supplement 4 was issued in December 1986, Supplement 5 was issued in January 1987, Supplement 6 was issued in March 1987, and Supplement 7 was issued in January 1988. The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This eighth supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved following issuance of Supplement 7. 5 figs., 3 tabs

  14. Final environmental statement related to the operation of Limerick Generating Station, Units 1 and 2, Docket Nos. 50-352 and 50-353, Philadelphia Electric Company

    International Nuclear Information System (INIS)

    1989-08-01

    In April 1984 the staff of the Nuclear Regulatory Commission issued its Final Environmental Statement (NUREG-0974) related to the operation of Limerick Generating Station, Units 1 and 2, (Docket Nos. 50-352 and 50-353), located on the Schuylkill River, near Pottstown, in Limerick Township, Montgomery and Chester Counties, Pennsylvania. The NRC has prepared this supplement to NUREG-0974 to present its evaluation of the alternative of facility operation with the installation of further severe accident mitigation design features. The NRC staff has discovered no substantial changes in the proposed action as previously evaluated in the Final Environmental Statement that are relevant to environmental concerns nor significant new circumstances or information relevant to environmental concerns and bearing on the licensing of Limerick Generating Station, Units 1 and 2. 15 refs., 10 tabs

  15. Safety Evaluation Report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2 (Docket Nos. 50-416 and 50-417)

    International Nuclear Information System (INIS)

    1984-10-01

    This report supplements the Safety Evaluation Report (NUREG-0831) issued in September 1981 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Mississippi Power and Light (MP and L) Company, Middle South Energy, Inc., and South Mississippi Electric Power Association as applicants and owners, for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2 (Docket Nos. 50-416 and 50-417, respectively). The facility is located on the east bank of the Mississippi River near Port Gibson in Claiborne County, Mississippi. This supplement provides information on the NRC staff's evaluation of requests for exemptions to NRC regulations pursuant to the Commission's direction in CLI-84-19, dated October 25, 1984

  16. Safety Evaluation Report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1985-06-01

    The Safety Evaluation Report for the application filed by Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and City of Dalton, Georgia, as applicants and owners, for licenses to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Burke County, Georgia, approximately 41.5 km (26 mi) south-southeast of Augusta, and on the Savannah River. Subject to favorable resolution of the items discussed in this report, the staff concludes that the applicant can operate the facility without endangering the health and safety of the public

  17. Final Environmental Statement related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1989-10-01

    In September 1981, the staff of the Nuclear Regulatory Commission (NRC) issued its Final Environmental Statement (NUREG-0775) related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446), located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. The NRC has prepared this supplement to NUREG-0775 to present its evaluation of the alternative of operating Comanche Peak with the installation of further severe-accident-mitigation design features. The NRC has discovered no substantial changes in the proposed action as previously evaluated in the Final Environmental Statement that are relevant to environmental concerns and bearing on the licensing of Comanche Peak Steam Electric Station, Units 1 and 2. 6 refs., 3 tabs

  18. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 3

    International Nuclear Information System (INIS)

    1985-01-01

    This report supplements the Safety Evaluation Report, NUREG-0847 (June 1982), Supplement No. 1 (September 1982), and Supplement No. 2 (January 1984) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the open and confirmatory items and license conditions identified in the Safety Evaluation Report

  19. Safety Evaluation Report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement No. 2

    International Nuclear Information System (INIS)

    1986-05-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and City of Dalton, Georgia, for a license to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement 1 to NUREG-1137 was issued by the staff in October 1985. The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This second supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved at the time the Safety Evaluation Report was issued. This supplement also discusses some new open and confirmatory items

  20. Safety evaluation report related to the operation of Midland Plant, Units 1 and 2. Docket Nos. 50-329 and 50-330, Consumers Power Company

    International Nuclear Information System (INIS)

    1982-10-01

    This report supplements the Safety Evaluation Report related to the Operation of Midland Plant, Units 1 and 2 (SER) (NUREG-0793) issued in May 1982 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Consumers Power Company, as applicant and owner, for licenses to operate the Midland Plant, Units 1 and 2 (Docket Nos. 50-329 and 50-330). The facility is located in the city of Midland in Midland County, Michigan. This supplement provides recent information regarding resolution of the soils settlement issue, one of the open items identified in the SER. Certain confirmatory issues identified in the SER also are addressed

  1. Safety evaluation report related to the operation of Seabrook Station, Units 1 and 2 (Docket Nos. 50-443 and 50-444)

    International Nuclear Information System (INIS)

    1986-05-01

    This report is Supplement 4 to the Safety Evaluation Report (SER, NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et al., for licenses to operate Seabrook Station, Units 1 and 2 (Docket Nos. STN 50-443 and STN 50-444). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hamphsire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  2. Safety evaluation report related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499)

    International Nuclear Information System (INIS)

    1987-01-01

    In April 1986 staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0781) regarding the application of Houston Lighting and Power Company (applicant and agent for the owners) for a license to operate South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). The facility is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. The first supplement to NUREG-0781 was issued in September 1986. This second supplement reports on the status of unresolved items in the Safety Evaluation Report and identifies certain additional items that have since been reviewed by the staff

  3. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50--390 and 50--391)

    International Nuclear Information System (INIS)

    1990-11-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), and Supplement No. 4 (March 1985), issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items and proposed license conditions identified in the SER

  4. Safety Evaluation Report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement No. 3

    International Nuclear Information System (INIS)

    1986-08-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and City of Dalton, Georgia, for a license to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement 1 to NUREG-1137 was issued by the staff in October 1985, and Supplement 2 was issued in May 1986. The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This third supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved at the time the Safety Evaluation Report was issued. This supplement also discusses some new open items

  5. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2, (Docket Nos. 50-390 and 50-391), Tennessee Valley Authority

    International Nuclear Information System (INIS)

    1992-06-01

    This report supplements the Safety Evaluation Report (SER), NUREG- 0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), and Supplement No. 8 (January 1992) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items, and proposed license conditions identified in the SER

  6. Safety evaluation report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Suppl. 22

    International Nuclear Information System (INIS)

    1984-03-01

    Supplement 22 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plants, Unit 1 and 2 (Docket Nos. 50-275 and 50-323), has been prepared jointly by the Office of Nuclear Reactor Regulation and the Region V Office of the US Nuclear Regulatory Commission. This supplement provides the criteria that were used by the staff to determine which of the allegations that have been evaluated and must be resolved prior to Unit 1 achieving criticality and operating at power level up to 5 percent of rated power (i.e., low power operation). The supplement also reports on the status of the staff's investigation, inspection and evaluation of 219 allegations or concerns that have been identified to the NRC as of March 9, 1984, excluding those recently received under 10 CFR 2.206 petitions

  7. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391)

    International Nuclear Information System (INIS)

    Tam, P.S.

    1991-04-01

    This report supplements the Safety Evaluation Report (SER), NUREG- 0847 (June 1982), Supplement No. 1' (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), and Supplement No. 5 (November 1990) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50--390 and 50--391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items, and proposed license conditions identified in the SER

  8. Safety evaluation report related to the operation of Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414). Supplement 2

    International Nuclear Information System (INIS)

    1984-06-01

    This report supplements the Safety Evaluation Report (NUREG-0954) and Supplement 1 with respect to the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Membership Corporation, and Saluda River Electric Cooperative, Inc., as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos., 50-413 and 50-414, respectively). The facility is located in York County, South Carolina, approximately 9.6 km (6 mi) north of Rock Hill and adjacent to Lake Wylie. This supplement provides more recent information regarding resolution or updating of some of the open and confirmatory issues and license conditions identified in the Safety Evaluation Report

  9. Safety evaluation report related to the operation of Seabrook Station, Units 1 and 2 (Docket Nos. 50-443 and 50-444)

    International Nuclear Information System (INIS)

    1987-10-01

    This report is Supplement No. 7 to the Safety Evaluation Report (NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et al. for licenses to operate Seabrook Station, Units 1 and 2 (Docket Nos. STN 50-443 and STN 50-444). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  10. Safety Evaluation Report related to the operation of Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414). Supplement No. 6

    International Nuclear Information System (INIS)

    1986-05-01

    This report supplements the Safety Evaluation Report (NUREG-0954) issued in February 1983 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Membership Corporation, Saluda River Electric Cooperative, Inc., and Piedmont Municipal Power Agency, as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414, respectively). The facility is located in York County, South Carolina, approximately 9.6 km (6 miles) north of Rock Hill and adjacent to Lake Wylie. This supplement provides additional information supporting the license for operation above 5% power and power ascension to full-power operation for Unit 2

  11. Safety Evaluation Report related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. STN 50-456 and STN 50-457)

    International Nuclear Information System (INIS)

    1988-06-01

    In November 1983, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1002) regarding the application filed by the Commonwealth Edison Company, as applicant and owner, for a license to operate Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457). The first supplement to NUREG-1002 was issued in September 1986; the second supplement was issued in October 1986; the third supplement was issued in May 1987; the fourth supplement was issued in July 1987 in support of the full power license for Unit 1; the fifth supplement was issued in December 1987 in support of the low power license for Unit 2. This sixth supplement to NUREG-1002 is in support of the full-power license for Unit 2 and provides the status of items that remained unresolved at the time Supplement 5 was published. The facility is located in Reed Township, Will County, Illinois

  12. Safety evaluation report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1988-01-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and the City of Dalton, Georgia, for licenses to operate Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This seventh supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved following issuance of Supplement 6, and documents completion of several Unit 1 license conditions

  13. Safety evaluation report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1986-12-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and City of Dalton, Georgia, for licenses to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement 1 to NUREG-0737 was issued by the staff in October 1985, Supplement 2 was issued in May 1986, and Supplement 3 was issued in August 1986. The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This fourth supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved at the time the Safety Evaluation Report was issued. This supplement also discusses some new items

  14. Safety evaluation report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1987-01-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and the City of Dalton, Georgia, for licenses to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement 1 to NUREG-1137 was issued by the staff in October 1985, Supplement 2 was issued in May 1986, Supplement 3 was issued in August 1986, and Supplement 4 was issued in December 1986. The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This fifth supplement to NUREG-1137 provides recent information regarding resolution of some of the open and confirmatory items that remained unresolved at the time the Safety Evaluation Report was issued

  15. Safety Evaluation report related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. STN 50-456 and STN 50-457)

    International Nuclear Information System (INIS)

    1987-07-01

    In November 1983, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1002) regarding the application filed by the Commonwealth Edison Company, as applicant and owner, for a license to operate Braidwood Station, Units 1 and 2 (Docket Nos. 50-456 and 50-457). The first supplement to NUREG-1002 was issued in September 1986; the second supplement to NUREG-1002 was issued in October 1986; the third supplement to NUREG-1002 was issued in May 1987. This fourth supplement to NUREG-1002 reports the status of certain items that remained unresolved at the time Supplement 3 was published. The facility is located in Reed Township, Will County, Illinois

  16. Safety-evaluation report related to the operation of Seabrook Station, Units 1 and 2. Docket Nos. 50-443 and 50-444

    International Nuclear Information System (INIS)

    1983-06-01

    This report is Supplement 2 to the Safety Evaluation Report (NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et al., for licenses to operate Seabrook Station, Units 1 and 2 (Docket Nos. STN 50-443 and STN 50-444). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  17. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 15

    International Nuclear Information System (INIS)

    Tam, P.S.

    1995-06-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), and Supplement No. 14 (December 1994) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items, and proposed license conditions identified in the SER

  18. Safety evaluation report related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1989-03-01

    In June 1985, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-1137) regarding the application of Georgia Power Company, Municipal Electric Authority of Georgia, Oglethorpe Power Corporation, and the City of Dalton, Georgia, for licenses to operate the Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425). Supplement 1 to NUREG-1137 was issued by the staff in October 1985, Supplement 2 was issued in May 1986, Supplement 3 was issued in August 1986, Supplement 4 was issued in December 1986, Supplement 5 was issued in January 1987, Supplement 6 was issued in March 1987, Supplement 7 was issued in January 1988, and Supplement 8 was issued in February 1989. The facility is located in Burke County, Georgia, approximately 26 miles south-southeast of Augusta, Georgia, and on the Savannah River. This ninth supplement to NUREG-1137 provides recent information regarding resolution of conditional items following issuance of Supplement 8

  19. Safety Evaluation Report related to the operation of Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441). Supplement No. 9

    International Nuclear Information System (INIS)

    1986-03-01

    Supplement No. 9 to the Safety Evaluation Report (NUREG-0887) on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group or CAPCO) for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 50-441), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Lake County, Ohio, approximately 35 miles northeast of Cleveland, Ohio. This supplement reports the staff's evaluation findings pertaining to the earthquake event that occurred in the vicinity of the Perry Nuclear Power Plant site on January 31, 1986, and is limited to that evaluation. Future supplemental reports will continue reporting on the status of new or unresolved issues since Supplement No. 8 was issued in January 1986

  20. Safety Evaluation Report related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499)

    International Nuclear Information System (INIS)

    1988-03-01

    In April 1986 the staff of the US Nuclear Regulartory Commission issued its Safety Evaluation Report (NURED-0781) regarding the application of Houston Lighting and Power Companany (applicant and agent for the owners) for a license to operate South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). The facililty is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. The first supplement to NUREG-0781 was issued in September 1986, the second supplement in January 1987, the third supplement in May 1987, and the fourth supplement in July 1987. This fifth supplement provides updated information on the issues that had been considered previously as well as the evaluation of issues that have arisen since the fourth supplement was issued. The evaluation resolves all the issues necessary to support the issuance of a full-power license for Unit 1

  1. Final environmental statement related to construction of Skagit Nuclear Power Project Units 1 and 2: (Docket Nos. 50-522 and 50-523)

    International Nuclear Information System (INIS)

    1975-05-01

    The proposed action is the issuance of construction permits to the Pudget Sound Power and Light Company, Pacific Power and Light Company, Washington Water Power Company and the Washington Public Power Supply System, for the construction of Skagit Nuclear Power Projects Units 1 and 2 (Docket Nos. 50-522 and 50-523) in Skagit County, Washington (about 64 miles north of Seattle and 6 miles ENE of Sedro Woolley). These units are scheduled for commercial service in 1982 and 1985, respectively. Each unit will employ a boiling-water nuclear reactor with a maximum expected thermal power level of 4100 MWt, which is considered in the assessments contained in this statement. At the 3800 MWt power level initially to be licensed, the net electrical capacity of each unit will be 1288 MWe. The exhaust steam from the turbine-generators will be cooled in condensers which will utilize one hyperbolic-type natural-draft cooling tower per unit to dissipate heat to the atmosphere. Water (106 cfs max.) for the cooling tower makeup (82.4 cfs) and other plant uses will be withdrawn from the Skagit River through Ranney Collectors embedded in the north bank of the river and pumped to the plant through a pipeline about 35,000 ft. long. Cooling tower blowdown (7 cfs max.) from the project and dilution water (20 cfs max.) will flow through a pipeline back to the river where it will be discharged through a diffuser

  2. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 17

    International Nuclear Information System (INIS)

    Tam, P.S.

    1995-10-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April.1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), Supplement No. 14 (December 1994), Supplement No. 15 (June 1995), and Supplement No. 16 (September 1995) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50--390 and 50--391). The facility is located in Rhea county, Tennessee, near the Watts Bar Dam on the Tennessee River. In this supplement, NRC examines the significant problems of construction quality and quality assurance effectiveness that led TVA to withdraw its certification in 1985 that Watts Bar Unit I was ready to load fuel. Also discussed are the extensive corrective actions performed by TVA according to its nuclear performance plans and other supplemental programs, and NRC's extensive oversight to determine whether the Watts Bar Unit 1 construction quality and TVA's operational readiness and quality assurance effectiveness are adequate for a low-power operating license to be issued. SSER 17 does not address Watts Bar Unit 2, except for the systems which are necessary to support Unit 1 operation

  3. Technical Specifications: Vogtle Electric Generating Plant, Unit Nos. 1 and 2 (Docket Nos. 50-424 and 50-425): Appendix ''A'' to License Nos. NPF-68 and NPF-79

    International Nuclear Information System (INIS)

    1989-02-01

    The Vogtle Electric Generating Plant, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public

  4. Technical Specifications, Vogtle Electric Generating Plant, Unit Nos. 1 and 2 (Docket Nos. 50-424 and 50-425): Appendix ''A'' to License Nos. NPF-68 and NPF-81

    International Nuclear Information System (INIS)

    1989-03-01

    The Vogtle Electric Generating Plant, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public

  5. Technical Specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-80

    International Nuclear Information System (INIS)

    1989-03-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  6. Technical specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-78

    International Nuclear Information System (INIS)

    1989-01-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  7. Safety evaluation report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Supplement No. 26

    International Nuclear Information System (INIS)

    1984-07-01

    Supplement 26 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plants, Units 1 and 2 (Docket Nos. 50-275 and 50-323), has been prepared jointly by the Office of Nuclear Reactor Regulation and the Region V Office of the US Nuclear Regulatory Commission. The supplement reports on the status of the staff's investigation, inspection and evaluation of those allegations or concerns that have been identified to the NRC as of July 8, 1984. The report specifically addresses those allegations which the staff determined must be satisfactorily resolved prior to full power operation of Diablo Canyon Unit 1

  8. Safety evaluation report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Supplement No. 25

    International Nuclear Information System (INIS)

    1984-07-01

    Supplement 25 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plants, Unit 1 and Unit 2 (Docket Nos. 50-275 and 50-323) has been prepared by the Office of Nuclear Reactor Regulation (NRR) of the US Nuclear Regulatory Commission. This supplement reports on the staff's inspection and evaluation efforts on the matter of piping and piping supports as related to the seven technical license conditions in an Order Modifying License issued by NRR on April 18, 1984

  9. Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530)

    International Nuclear Information System (INIS)

    1984-10-01

    Supplement No. 6 to the Safety Evaluation Report for the application filed by Arizona Public Service Company, et al., for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizona, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of (1) additional information submitted by the applicant since Supplement No. 5 was issued and (2) matters that the staff had under review when Supplement No. 5 was issued

  10. Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530). Supplement No. 7

    International Nuclear Information System (INIS)

    1984-12-01

    Supplement No. 7 to the Safety Evaluation Report for the application filed by Arizona Public Service Company et al. for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizona, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of: (1) additional information submitted by the applicant since Supplement No. 6 was issued; and (2) matters that the staff had under review when Supplement No. 6 was issued

  11. Safety Evaluation Report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Supplement No. 28

    International Nuclear Information System (INIS)

    1985-04-01

    Supplement 28 to the Safety Evaluation Report for the Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323) has been prepared jointly by the Office of Nuclear Reactor Regulation and the Region V Office of the US Nuclear Regulatory Commission. The supplement reports on the status of the staff's investigation, inspection, and evaluation of those allegations or concerns that have been identified to the NRC as of March 1, 1985

  12. Safety-evaluation report related to the operation of Diablo Canyon Nuclear Power Plants, Units 1 and 2. Docket Nos. 50-275 and 50-323. Supplement No. 18

    International Nuclear Information System (INIS)

    1983-08-01

    Supplement 18 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for licenses to operate Diablo Canyon Nuclear Power Plants, Units 1 and 2 (Docket Nos. 50-275 and 50-323), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports on the verification effort for Diablo Canyon Unit 1 that was performed between November 1981 and the present in response to Commission Order CLI-81-30 and an NRC letter to the licensee

  13. Safety evaluation report: related to the operation of Seabrook Station, Units 1 and 2, Docket Nos. 50-443 and 50-444, Public Service Company of New Hampshire, et al

    International Nuclear Information System (INIS)

    1983-03-01

    The Safety Evaluation Report for the application filed by the Public Service Company of New Hampshire, et al., for licenses to operate Seabrook Station, Units 1 and 2 (Docket Nos. STN 50-443 and STN 50-444), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  14. Safety Evaluation Report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323)

    International Nuclear Information System (INIS)

    1984-07-01

    Supplement 27 to the Safety Evaluation Report for Pacific Gas and Electric Company's application for a license to operate Diablo Canyon Nuclear Power Plant, Unit 1 (Docket No. 50-275), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement addresses the revisions to the license conditions and to the Technical Specifications as they relate to Amendment 10 to Diablo Canyon, Unit 1 Facility Operating License, DPR-76

  15. Conformance to Regulatory Guide 1.97, Joseph M. Farley Nuclear Plant, Unit Nos. 1 and 2 (Docket No. 50-348 and 50-364)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-05-01

    This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97 for Unit Nos. 1 and 2 of the Joseph M. Farley Nuclear Plant and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

  16. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446). Supplement No. 7

    International Nuclear Information System (INIS)

    1985-01-01

    Supplement 7 to the Safety Evaluation Report for the Texas Utilities Electric Company application for a license to operate Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445, 50-446), located in Somervell County, Texas, has been jointly prepared by the Office of Nuclear Reactor Regulation and the Comanche Peak Technical Review of the US Nuclera Regulatory Commission. This supplement provides the results of the staff's evaluation and resolution of approximately 80 technical concerns and allegations in the areas of Electric/Instrumentation and Test Programs regarding construction and plant readiness testing practices at the Comanche Peak facility. Issues raised during Atomic Safety and Licensing Board hearings will be dealt with in future supplements to the Safety Evaluation Report

  17. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446). Supplement No. 8

    International Nuclear Information System (INIS)

    1985-02-01

    Supplement 8 to the Safety Evaluation Report for the Texas Utilities Electric Company application for a license to operate Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445, 50-446), located in Somervell County, Texas, has been jointly prepared by the Office of Nuclear Reactor Regulation and the Comanche Peak Technical Review Team of the US Nuclear Regulatory Commission. This Supplement provides the results of the staff's evaluation and resolution of approximately 80 technical concerns and allegations relating to civil and structural and miscellaneous issues regarding construction and plant readiness testing practices at the Comanche Peak facility. Issues raised during recent Atomic Safety and Licensing Board hearings will be dealt with in future supplements to the Safety Evaluation Report

  18. Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Dockets Nos. STN 50-528, STN 50-529, and STN 50-530)

    International Nuclear Information System (INIS)

    1987-03-01

    Supplement No. 11 to the Safety Evaluation Report for the application filed by Arizona Public Service Company et al. for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizone, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of (1) additional information submitted by the applicant since Supplement No. 10 was issued and (2) other matters requiring staff review since Supplenent No. 10 was issued, specifically those issues that required resolution before Unit 3 low-power licensing

  19. Safety evaluation report related to the operation of Catawba Nuclear Station, Units 1 and 2. Docket Nos. 50-413 and 50-414, Duke Power Company, et al

    International Nuclear Information System (INIS)

    1983-02-01

    The Safety Evaluation Report for the application filed by Duke Power Company, North Carolina Municipal Power Agency Number 1, North Carolina Electric Membership Corporation, and Saluda River Electric Cooperative, Inc. as applicants and owners, for licenses to operate the Catawba Nuclear Station, Units 1 and 2 (Docket Nos. 50-413 and 50-414), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in York County, South Carolina, approximately 9.6 km (6 mi) north of Rock Hill and adjacent to Lake Wylie. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  20. Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530). Supplement No. 9

    International Nuclear Information System (INIS)

    1985-12-01

    Supplement No. 9 to the Safety Evaluation Report for the application filed by Arizona Public Service Company et al. for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2 and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizona, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of: (1) additional information submitted by the applicant since Supplement No. 8 was issued; and (2) matters that the staff had under review when Supplement No. 8 was issued, specifically those issues which required resolution prior to Unit 2 fuel loading and testing up to 5% of full power

  1. Safety Evaluation Report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Supplement No. 33

    International Nuclear Information System (INIS)

    1986-05-01

    Supplement 33 to the Safety Evaluation Report for the Pacific Gas and Electric Company's Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323) has been prepared jointly by the Office of Nuclear Reactor Regulation and the Region V Office of the US Nuclear Regulatory Commission. The supplement reports on the status of the staff's investigation, inspection, and evaluation of allegations and concerns that have been identified to the NRC through March 1986. The report includes a complete listing of all allegations and concerns, indicating the status of their resolution. The NRC staff concludes that the technical issues raised in the allegations with regard to the design, construction, and safe operation of Diablo Canyon Units 1 and 2 have been satisfactorily resolved and no further action is required

  2. Safety evaluation report: related to the operation of Perry Nuclear Power Plant, Units 1 and 2, Docket Nos. 50-440 and 50-441, Cleveland Electric Illuminating Company

    International Nuclear Information System (INIS)

    1982-08-01

    Supplement No. 1 to the Safety Evaluation Report on the application filed by the Cleveland Electric Illuminating Company on behalf of itself and as agent for the Duquesne Light Company, the Ohio Edison Company, the Pennsylvania Power Company, and the Toledo Edison Company (the Central Area Power Coordination Group, CAPCO), as applicants and owners, for a license to operate the Perry Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-440 and 441). The facility is located near Lake Erie in Lake County, Ohio. This supplement has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

  3. Conformance to Regulatory Guide 1.97 Browns Ferry Nuclear Plant, Unit Nos. 1, 2 and 3 (Docket Nos. 50-259, 50-260, and 50-296)

    International Nuclear Information System (INIS)

    Udy, A.C.

    1985-07-01

    This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1, 2 and 3 of the Browns Ferry Nuclear Plant and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

  4. EPA Administrative Enforcement Dockets

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Administrative Enforcement Dockets database contains the electronic dockets for administrative penalty cases filed by EPA Regions and Headquarters. Visitors...

  5. Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530): Final environmental statement

    International Nuclear Information System (INIS)

    1982-02-01

    The proposed action is the issuance of operating licenses to the Arizona Public Service Company (APS, applicant) for the startup and operation of PVNGS, Units 1, 2, and 3, located in Maricopa County, about 24 km (15 mi) west of Buckeye, Arizona. The information in this statement represents the second assessment of the environmental impact associated with PVNGS Units 1, 2, and 3 pursuant to the guidelines of the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations (10 CFR) Part 51 of the Commissions's Regulations. After receiving an application in July 1974 to construct this station, the staff carried out a review of impacts that would occur during its construction and operation. That evaluation was issued as a Final Environmental Statement/emdash/Construction Phase (FES-CP). After this environmental review, a safety review, an evaluation by the Advisory Committee on Reactor Safeguards, and public hearings in Phoenix, Arizona, the US Nuclear Regulatory Commission issued Construction Permits Nos. CPPR-141, CPPR-142, and CPPR-143 for the construction of PVNGS Units 1, 2, and 3. As of September 1981, the construction of Unit 1 was about 92 percent complete, Unit 2 was 68 percent complete, and Unit 3 was 26 percent complete. 11 figs., 21 tabs

  6. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446). Supplement No. 11

    International Nuclear Information System (INIS)

    1985-05-01

    Supplement 11 to the Safety Evaluation Report for the Texas Utilities Electric Company application for a license to operate Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445, 50-446), located in Somervell County, Texas, has been jointly prepared by the Office of Nuclear Reactor Regulation and the Comanche Peak Technical Review Team (TRT) of the US Nuclear Regulatory Commission (NRC) and is in two parts. Part 1 (Appendix 0) of this supplement provides the results of the TRT's evaluation of approximately 124 concerns and allegations relating specifically to quality assurance and quality control (QA/QC) issues regarding construction proctices at the Comanche Peak facility. Part 2 (Appendix P) contains an overall summary and conclusion of the QA/QC aspects of the NRC Technical Review Team efforts as reported in supplemental Safety Evaluation Report SERs 7, 8, 9, and 10. Since QA/QC issues are also contained in each of the other supplements, the TRT considered that such a summary and conclusion from all supplements was necessary for a complete TRT description of QA/QC activities at Comanche Peak

  7. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, Tennessee Valley Authority. Supplement number 20

    International Nuclear Information System (INIS)

    1996-02-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), Supplement No. 14 (December 1994), Supplement No. 15 (June 1995), Supplement No. 16 (September 1995), Supplement No. 17 (October 1995), Supplement No. 18 (October 1995), and Supplement No. 19 (November 1995) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the issues identified in the SER

  8. Conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3, Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, Surry Unit Nos. 1 and 2 (Docket Nos. 50-334, 50-338, 50-339, 50-280, and 50-281)

    International Nuclear Information System (INIS)

    Haroldsen, R.

    1985-09-01

    This report provides a review of the submittals for Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, and Surry, Unit Nos. 1 and 2, for conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3. The specific plants selected were reviewed as a group because of similarity in type and applicability of review items

  9. Power Reactor Docket Information

    International Nuclear Information System (INIS)

    1976-08-01

    A listing of citations and subject indexing for documentation associated with the regulation of commercial nuclear facilities is presented. This documentation for the most part is that submitted to the U.S. Nuclear Regulatory Commission in accordance with regulatory processes in support of applications for construction permits and operating licenses. The citations are listed in Docket Number order. The citations are preceded by two tables of contents that allow the correlation of Docket Numbers and Facility Names. An alphabetic subject index follows the citations

  10. Safety Evaluation Report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Supplement No. 30

    International Nuclear Information System (INIS)

    1985-04-01

    Supplement 30 to the Safety Evaluation Report for the application by the Pacific Gas and Electric Company (PG and E) to operate the Diablo Canyon Nuclear Power Plant - Unit 2 (Docket No. 50-323) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. SSER 30 reports on the staff's technical review and evaluation of the design and analysis of Unit 2 piping systems and pipe supports. The staff effort includes an evaluation of PG and E's treatment of issues raised during the Unit 1 design verification, actions resulting from low power License Condition 2.C.(11) in the Unit 1 low power license DPR-76 and the Unit 2 applicability and resolution of certain allegations related to piping and supports

  11. Safety evaluation report related to the operation of Palo Verde nuclear generating station, Units 1, 2, and 3. Docket Nos. STN 50-528, STN 50-529, and STN 50-530, Arizona Public Service Company

    International Nuclear Information System (INIS)

    1982-05-01

    On November 13, 1981, the Nuclear Regulatory Commission (NRC) staff issued its Safety Evaluation Report (SER) relating to the application for licenses to operate the Palo Verde Nuclear Generating Station, Unit Nos. 1, 2 and 3 (PVNGS 1-3); Supplement No. 1 to the SER was issued on February 4, 1982. In the SER and Supplement No. 1, the staff identified certain issues where either further information was required of the applicant or additional staff effort was necessary to complete the review of the application. The purpose of this supplement is to update the SER by providing (1) the evaluation of additional information submitted by the applicant since Supplement No. 1 to the SER was issued, and (2) the evaluation of the matters that the staff had under review and Supplement No. 1 was issued

  12. 76 FR 52992 - Notice of Acceptance for Docketing of the Application and Notice of Opportunity for Hearing...

    Science.gov (United States)

    2011-08-24

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0166; Docket Numbers 50-352 and 50-353] Notice of Acceptance for Docketing of the Application and Notice of Opportunity for Hearing Regarding Renewal of Facility Operating License Nos. NPF-39 and NPF-85 for an Additional 20-Year Period, Exelon Generation Company, LLC, Limerick Generating Station The U.S....

  13. Procedure for Electronic Management of Rulemaking and Other Docketed Records in the Federal Docket Management System

    Science.gov (United States)

    This procedure identifies the specific requirements, processes and supporting documents EPA uses to electronically manage rulemaking and other docketed records in the Federal Docket Management System (FDMS).

  14. 22 CFR 102.27 - Docket.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Docket. 102.27 Section 102.27 Foreign Relations... other than the Director of the Office of Aviation and summaries of oral communications prepared in...) All comments submitted under this subpart and placed in the docket, are available for public...

  15. Power Reactor Docket Information. Annual cumulation (citations)

    International Nuclear Information System (INIS)

    1977-12-01

    An annual cumulation of the citations to the documentation associated with civilian nuclear power plants is presented. This material is that which is submitted to the U.S. Nuclear Regulatory Commission in support of applications for construction and operating licenses. Citations are listed by Docket number in accession number sequence. The Table of Contents is arranged both by Docket number and by nuclear power plant name

  16. 78 FR 49305 - Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2013-08-13

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-445 and 50-446; NRC-2013-0182] Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2; Application for Amendment to Facility... Operating License Nos. NPF-87 and NPF-89 for the Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2...

  17. 75 FR 80496 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Science.gov (United States)

    2010-12-22

    ... in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public... 155, subpart C. Section 3(g) of FIFRA provides, among other things, that the registrations of...

  18. 76 FR 60822 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Science.gov (United States)

    2011-09-30

    ... placed on the Internet and will be publicly available only in hard copy form. Publicly available docket... available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg... 155, subpart C. Section 3(g) of FIFRA provides, among other things, that the registrations of...

  19. 76 FR 38166 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Science.gov (United States)

    2011-06-29

    ... in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public.... Section 3(g) of FIFRA provides, among other things, that the registrations of pesticides are to be...

  20. 77 FR 18810 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Act

    Science.gov (United States)

    2012-03-28

    ... and will be publicly available only in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov , or, if only available in hard copy.... Section 3(g) of FIFRA provides, among other things, that the registrations of pesticides are to be...

  1. 7 CFR 1781.17 - Docket preparation and processing.

    Science.gov (United States)

    2010-01-01

    ... preparation, with a list of documents to be included in the docket. (3) Objectives of the docket. The docket.... (b) Loan processing by State Office—(1) Review of the docket. The processing office will check the... for authorized purposes. (v) Actions are in compliance with requirements of applicable Federal and...

  2. 76 FR 56968 - [Docket No. FAA-2011-0490; Airspace Docket No. 11-AWP-5

    Science.gov (United States)

    2011-09-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2011... Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies Class E airspace at Tonopah, NV, to... reference action under 1 CFR Part 51, subject to the annual revision of FAA Order 7400.9 and publication of...

  3. 75 FR 6223 - PSEG Nuclear LLC; Hope Creek Generating Station and Salem Nuclear Generating Station, Unit Nos. 1...

    Science.gov (United States)

    2010-02-08

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-272, 50-311 and 50-354; NRC-2010-0043] PSEG Nuclear LLC; Hope Creek Generating Station and Salem Nuclear Generating Station, Unit Nos. 1 and 2...-70, and DPR-75, issued to PSEG Nuclear LLC (PSEG, the licensee), for operation of the Hope Creek...

  4. 78 FR 18586 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Acts

    Science.gov (United States)

    2013-03-27

    ...With this document, EPA is opening the public comment period for several registration reviews. Registration review is EPA's periodic review of pesticide registrations to ensure that each pesticide continues to satisfy the statutory standard for registration, that is, the pesticide can perform its intended function without unreasonable adverse effects on human health or the environment. Registration review dockets contain information that will assist the public in understanding the types of information and issues that the Agency may consider during the course of registration reviews. Through this program, EPA is ensuring that each pesticide's registration is based on current scientific and other knowledge, including its effects on human health and the environment. This document also announces the Agency's intent not to open registration review dockets for iodomethane or ethametsulfuron-methyl. Iodomethane and ethametsulfuron-methyl are undergoing phase-outs of all U.S. pesticide registrations. The cancellations of the iodomethane end use registrations became effective on December 31, 2012, and the cancellation of the sole technical product registration will become effective on December 1, 2015. The cancellations of all ethametsulfuron-methyl product registrations became effective on February 20, 2013. Therefore, iodomethane and ethametsulfuron-methyl are not scheduled for review under the registration review program. This document also announces the registration review case closures for the pesticides alkyl amine hydrochloride (case 3051) and halofenozide (case 7425), and the availability of their respective Case Closure Documents. The cancellation of all alkyl amine hydrochloride registrations became effective on October 17, 2012. The cancellation of all U.S. halofenozide registrations became effective December 21, 2012. These case closure are being announced herein with no comment period.

  5. Tu nos aposte protege

    DEFF Research Database (Denmark)

    Frederiksen, Britta Olrik

    2007-01-01

    Aspirationen af p, t og k i dansk er stedmoderligt behandlet af den gren af den historiske sprogforskning der bygger på skriftligt kildemateriale. Skrivemåden tu nos aposte protege for tu nos ab hoste protege 'bekyt du os mod fjenden' i en tilskrift fra anden halvdel af 1300-tallet i...

  6. 29 CFR 501.38 - Notice of docketing.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 501.38 Section 501.38 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE...

  7. 29 CFR 502.38 - Notice of docketing.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 502.38 Section 502.38 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE...

  8. 78 FR 35990 - All Operating Boiling-Water Reactor Licensees With Mark I And Mark II Containments; Docket Nos...

    Science.gov (United States)

    2013-06-14

    ... of Operation Under Severe Accident Conditions (Effective Immediately) I. The Licensees identified in... radioactive materials if the venting systems were used during severe accident conditions. The NRC staff..., 2012). Option 2 in SECY-12-0157 was to modify EA-12-050 to require severe accident capable vents (i.e...

  9. Callaway Plant Units 1 and 2: Final environmental statement (Docket Nos. STN 50-483 and STN 50-486)

    International Nuclear Information System (INIS)

    1975-03-01

    The proposed action is the issuance of a construction permit to the Union Electric company for the construction of the Callaway Plant Units 1 and 2. The Callaway Plant, located 5 m north of the Missouri River in Callaway County, Missouri, will employ a pressurized water reactor to produce up to 3425 megawatts thermal (MWt) from each unit. A steam turbine-generator will use the heat to provide 1120 MWe (net) of electrical power capacity. A stretch power level of 3579 MWt (1160 MWe) is anticipated at a future date and is considered in the assessments contained in this statement. The exhaust steam will be cooled in a closed cycle mode, with water from the Missouri River. Constructing the plant and adjacent facilities will disturb an area of about 600 acres, of which less than 300 acres will be occupied by the operating plant and road and rail access to it. The land presently consists of cropland, pasture and forest. About 1140 acres will be required for the transmission line routes. The land presently consists of forest, pasture and cropland. No unique land usage is involved. Siltation and erosion during construction generally will have minor adverse effects, based upon the extent of protection measures the applicant plans to impose. The effect on Logan Creek is expected to be minor, but further assessment is needed, including possible additional precautions. About 14% of the benthic invertebrate population will be lost in the rectangular area defined by the river width and the length of the area to be dredged for shoreline structures. 28 figs., 53 tabs

  10. 78 FR 35984 - Interim Eligible Class of NRC-Licensed Facilities; Docket Nos. (as Shown in Attachment 1...

    Science.gov (United States)

    2013-06-14

    ... name III. place of birth IV. gender V. date of birth VI. height VII. weight VIII. race: (choose one of...-American [cir] Hispanic or Latino [cir] Native Hawaiian or other Pacific Islander [cir] White IX. residence and employer addresses of person fingerprinted: Complete mailing addresses of current residence and...

  11. Montague Nuclear Power Station, Units 1 and 2: Final environmental statement (Docket Nos. 50-496 and 50-497)

    International Nuclear Information System (INIS)

    1977-02-01

    The proposed action is the issuance of construction permits to the Northeast Nuclear Energy Company for the construction of the Montague Nuclear Power Station, Units 1 and 2, located on the Connecticut River in the Town of Montague, Massachusetts. The plant will employ two identical boiling-water reactors to produce up to 3579 megawatts thermal (MWt) each. Two steam turbine-generators will use this heat to provide 1150 MWe (net) of electrical power capacity from each turbine-generator. A design power level of 3759 MWt (1220 Mwe net) for each unit is anticipated at a future date and is considered in the assessments contained in this statement. The waste heat will be rejected through natural-draft cooling towers using makeup water obtained from and discharged to the Connecticut River. The 1900-acre site is about 90% forest, with the remaining acreage in transmission-line corridor and old-field vegetation. The total loss of mixed-age forest will be 1273 acres. Nodesignated scenic areas will be crossed. Sixty acres of public lands, State forests, and parks will be lost to transmission facilities as well as losses associated with crossings of 2.0 miles of water bodies and 11.9 miles of wetlands. The maximum estimated potential loss of salable wood products will be $849,600. A maximum of 85.8 cfs of cooling water will be withdrawn from the Connecticut River. A maximum of 17.2 cfs will be returned to the river with the dissolved solids concentration increased by a factor of about 5. A maximum of 68.6 cfs will be evaporated to the atmosphere by the cooling towers. 143 refs., 58 figs., 69 tabs

  12. Fulton Generating Station Units 1 and 2 (Docket Nos. 50-463 and 50-464): Final environmental statement

    International Nuclear Information System (INIS)

    1975-04-01

    The proposed action is the issuance of construction permits to the Philadelphia Electric Company for the construction of the Fulton Generating Station, Units 1 and 2, located in Fulton and Drumore Townships, Lancaster County, Pennsylvania. Makeup water for cooling will be withdrawn form Conowingo Pond at a maximum rate of 43,000 gpm. The dissolved solids content of the blowdown water will be increased by a factor of about two. The remainder of the water will be evaporated to the atmosphere by cooling towers. About 10 acres offsite, some 7 acres of which is woodland, will be used for railroad-spur construction. About 0.25 mile of new transmission-line rights-of-way (9 acres) will be needed, although 49 miles of new transmission line, which will require about 3 miles of selective clearing, will be constructed on existing rights-of-way. An unestablished amount of land will be used for access-road construction, but the applicant will use existing roadway corridors where feasible. A small loss of consumer species will result from loss of habitat. Some loss of benthic and pelagic organisms in Conowingo Pond will be caused by intake and discharge construction. The Station's thermal and chemical discharges will meet the State water-quality standards. The duration of additional ground-level fog caused by Station operation is expected to be less than 3 hr/year. (Sect. 5.3.3). No observable effects are expected from salt deposition from cooling-tower drift. (Sect. 5.3.3). Decomposers, primary producers, and zooplankton will be entrained and killed in the cooling-tower system; they, as well as benthic organisms, will be affected by the heated-water discharge. This loss will have little effect on the pond food web. 30 figs., 76 tabs

  13. Technical specifications: Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323)

    International Nuclear Information System (INIS)

    1985-08-01

    Safety limits and limiting safety system settings are presented for the reactivity control systems; power distribution limits; instrumentation; reactor coolant system; emergency core cooling system; containment systems; plant systems; electrical power systems; refueling operations; special test exceptions; radioactive effluents; and radiological environmental monitoring

  14. South Texas project, Units 1 and 2: Final environmental statement (Docket Nos. 50-498 and 50-499)

    International Nuclear Information System (INIS)

    1975-03-01

    The proposed action is the issuance of a construction permit to the Houston Lighting and the Power Company, acting as Project manager on behalf of itself, the City Public Service Board of San Antonio, Central Power and Light Company, and the City of Austin, for the construction of the South Texas Project (STP) Units 1 and 2, located in Matagorda County, Texas. A total of 12,352 acres will be utilized for the STP site. Construction-related activities on the site will disturb about 610 acres not including the 7310 acres of inundated by the STP cooling lake and embankments, which will be constructed in conjunction with the project. Approximately 400 miles of transmission-line corridors will require about 5685 acres of land for the right-of-way. An access road and a railroad spur will affect about 60 acres. Farm to Market Road 521 will be rerouted north around the STP exclusion area. Plant construction will involve extensive community impacts. Two families will be displaced from the site. Traffic on local roads will increase due to construction and commuting activities. The influx of construction workers' families (2100 peak work force) is expected to cause no major housing or school problems. There will be a demand for increased services in Matagorda County. The proposed plan to alter Little Robbins Slough and the resultant 65% reduction in the watershed supplying freshwater inflow to the upper marsh may cause the displacement of numerous freshwater species and reduce its desirability as a nursery for estuarine-dependent organisms. Studies to determine the need for freshwater makeup will be required. 39 figs., 76 tabs

  15. Technical Specifications, Byron Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-454 and STN 50-455). Appendix A to license No. NPF-37

    International Nuclear Information System (INIS)

    1985-02-01

    The Byron Station, Unit No. 1 and Unit No. 2 Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. Specifications are presented for limiting conditions for operation for the reactor control system, power distribution limits, instrumentation, primary coolant circuit, ECCS, containment systems, plant systems, electrical power systems, refueling operations, radioactive effluents, and radiological environmental monitoring

  16. Technical specifications: McGuire Nuclear Station, Unit Nos. 1 and 2. Docket Nos. 50-369 and 50-370

    International Nuclear Information System (INIS)

    Anderson, F.

    1983-03-01

    Information is presented concerning safety limits for operation; control systems; power distribution limits; instrumentation; primary coolant circuit; emergency core cooling systems; containment systems; steam turbines and secondary coolant circuits; electrical equipment; refueling operations; radioactive effluents; and reactor site

  17. Safety Evaluation Report related to the operation of Shearon Harris Nuclear Power Plant, Unit No. 1 (Docket No. STN 50-400). Supplement No. 4

    International Nuclear Information System (INIS)

    1986-10-01

    This report, Supplement No. 4 to the Safety Evaluation Report for the application filed by the Carolina Power and Light Company and North Carolina Eastern Municipal Power Agency (the applicants) for a license to operate the Shearon Harris Nuclear Power Plant Unit 1 (Docket No. 50-400), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1, 2, and 3

  18. Safety Evaluation Report related to the operation of Shearon Harris Nuclear Power Plant, Unit No. 1 (Docket No. STN 50-400). Supplement No. 3

    International Nuclear Information System (INIS)

    1986-05-01

    This report, Supplement No. 3 to the Safety Evaluation Report for the application filed by the Carolina Power and Light Company and North Carolina Eastern Municipal Power Agency (the applicants) for a license to operate the Shearon Harris Nuclear Power Plant Unit 1 (Docket No. 50-400), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1 and 2

  19. Offre pour nos membres

    CERN Multimedia

    Staff Association

    2016-01-01

    Walibi Rhône-Alpes accueille son événement Halloween FreakShow le week-end du 15 et 16 octobre puis tous les jours du 20 octobre au 02 novembre 2016 ! ouverture prolongée jusqu’à 19h et feu d’artifices chaque soir 29, 30 et 31 octobre ! Loup-garou show; 1 labyrinthe; jeu de piste sur le parc (et nombreux lots à gagner); animations (sculpture sur citrouilles et maquillage) et d'autres surpises ! Tarifs pour nos membres : Entrée "Zone terrestre": 23 € au lieu de 29 €. Entrée gratuite pour les enfants de moins de 3 ans, avec accès aux attractions limité. Parking gratuit.

  20. 75 FR 2163 - Constellation Energy; Notice of Docketing of Special Nuclear Material License SNM-2505 Amendment...

    Science.gov (United States)

    2010-01-14

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 72-8; NRC-2010-0011] Constellation Energy; Notice of Docketing of Special Nuclear Material License SNM-2505 Amendment Application for the Calvert Cliffs... Constellation Energy (Constellation) to amend its Special Nuclear Material License No. SNM-2505, under the...

  1. 10 CFR 2.643 - Acceptance and docketing of application for limited work authorization.

    Science.gov (United States)

    2010-01-01

    ... application is docketed, the Director will cause to be published in the Federal Register and send to the... complete. (e) If part two of the application is docketed, the Director will cause to be published in the... § 2.101(a)(9) is incomplete and not acceptable for processing, the Director of New Reactors or the...

  2. 76 FR 79173 - Registration Review; Pesticide Dockets Opened for Review and Comment, and Notice of Availability...

    Science.gov (United States)

    2011-12-21

    ... placed on the Internet and will be publicly available only in hard copy form. Publicly available docket... available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg.... Section 3(g) of FIFRA provides, among other things, that the registrations of pesticides are to be...

  3. 75 FR 38521 - Registration Review; Biopesticide Dockets Opened for Review and Comment

    Science.gov (United States)

    2010-07-02

    ... in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public.... Section 3(g) of FIFRA provides, among other things, that the registrations of pesticides are to be...

  4. 75 FR 60119 - Registration Review; Antimicrobial Pesticide Dockets Opened for Review and Comment

    Science.gov (United States)

    2010-09-29

    ... and will be publicly available only in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov , or, if only available in hard copy... 155, subpart C. Section 3(g) of FIFRA provides, among other things, that the registrations of...

  5. 75 FR 60117 - Registration Review; Biopesticides Dockets Opened for Review and Comment

    Science.gov (United States)

    2010-09-29

    ... publicly available only in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov , or, if only available in hard copy, at the OPP Regulatory.... Section 3(g) of FIFRA provides, among other things, that the registrations of pesticides are to be...

  6. 78 FR 21085 - Establishment of a Public Docket for Administrative Detention Under the Food and Drug...

    Science.gov (United States)

    2013-04-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Chapter I [Docket No. FDA-2013-N-0365] Establishment of a Public Docket for Administrative Detention Under the Food and Drug Administration Safety and Innovation Act AGENCY: Food and Drug Administration, HHS. ACTION: Establishment of...

  7. 78 FR 16824 - Tobacco Product Manufacturing Practice; Establishment of a Public Docket

    Science.gov (United States)

    2013-03-19

    ... manufacturing operations. DATES: Submit electronic or written comments on the tobacco companies' recommendations... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Chapter I [Docket No. FDA-2013-N-0227] Tobacco Product Manufacturing Practice; Establishment of a Public Docket AGENCY: Food...

  8. NOAA NOS SOS, EXPERIMENTAL - Currents

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have currents data. *These services are for testing and evaluation use...

  9. NOAA NOS SOS, EXPERIMENTAL - Wind

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have wind data. *These services are for testing and evaluation use only*...

  10. Safety evaluation report related to the operation of South Texas Project, Unit 2 (Docket No. 50-499)

    International Nuclear Information System (INIS)

    1989-03-01

    In April 1986 the staff of the US Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0781) regarding the application of Houston Lighting and Power Company (applicant and agent for the owners) for a license to operate South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). The facility is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. The first supplement to NUREG-0781 was issued in September 1986, the second supplement in January 1987, the third supplement in May 1987, the fourth supplement in July 1987, the fifth supplement in March 1988, and the sixth supplement in January 1989. This seventh supplement, which supports the issuance of a full-power license for Unit 2, provides updated information on the issues that had been considered previously as well as the evaluation of issues that have arisen since the sixth supplement was issued. The evaluation resolves all the issues necessary to support the issuance of a full-power license for Unit 2. 2 refs., 2 figs., 1 tab

  11. Safety Evaluation Report related to the operation of South Texas Project, Unit 2 (Docket No. 50-499)

    International Nuclear Information System (INIS)

    1989-01-01

    In April 1986 the staff of the US Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0781) regarding the application of Houston Lighting and Power Company (applicant and agent for the owners) for a license to operate South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). The facility is located in Matagorda County, Texas, west of the Colorado River, 8 miles north-northwest of the town of Matagorda and about 89 miles southwest of Houston. The first supplement to NUREG-0781 was issued in September 1986, the second supplement in January 1987, the third supplement in May 1987, the fourth supplement in July 1987 and the fifth supplement in March 1988. This sixth supplement provides updated information on the issues that had been considered previously as well as the evaluation of issues that have arisen since the fifth supplement was issued. The evaluation resolves all the issues necessary to support the issuance of a low-power license for Unit 2

  12. Technical Specifications, Catawba Nuclear Station, Unit Nos. 1 and 2 (Docket Nos. 50-413 and 50-414). Appendix ''A'' to License Nos. NPF-35 and NPF-48

    International Nuclear Information System (INIS)

    1986-02-01

    These specifications cover: definitions, safety limits and limiting safety system settings, bases, limiting conditions for operation and surveillance requirements, design features, and administrative controls

  13. Technical Specifications, Catawba Nuclear Station, Unit Nos. 1 and 2 (Docket Nos. 50-413 and 50-414). Appendix ''A'' to License Nos. NPF-35 and NPF-52

    International Nuclear Information System (INIS)

    1986-05-01

    These specifications cover: definitions, safety limits and limiting safety system settings, bases, limiting conditions for operation and surveillance requirements, design features, and administrative controls

  14. A Internet que nos protege

    Directory of Open Access Journals (Sweden)

    Luana Negrelly Saraiva

    2001-02-01

    Full Text Available A partir de uma análise das relações interpessoais nos canais de chat, pretende-se mostrar a Internet como um espaço de proteção da mesma sociedade repressora que a criou, abrindo portas para o desenvolvimento e o resgate dos valores humanos.

  15. Priority Queuing on the Docket: Universality of Judicial Dispute Resolution Timing

    Directory of Open Access Journals (Sweden)

    Satyam Mukherjee

    2018-01-01

    Full Text Available This paper analyzes court priority queuing behavior by examining the time lapse between when a case enters a court's docket and when it is ultimately disposed of. Using data from the Supreme courts of the United States, Massachusetts, and Canada we show that each court's docket features a slow decay with a decreasing tail. This demonstrates that, in each of the courts examined, the vast majority of cases are resolved relatively quickly, while there remains a small number of outlier cases that take an extremely long time to resolve. We discuss the implications for this on legal systems, the study of the law, and future research.

  16. 40 CFR 1612.3 - Published reports and material contained in the public incident investigation dockets.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Published reports and material... Published reports and material contained in the public incident investigation dockets. (a) Demands for published investigation reports should be directed to the Office of Congressional and Public Affairs, U.S...

  17. 75 FR 57782 - Registration Review; Pesticide Dockets Opened for Review and Comment; Amended Work Plan for...

    Science.gov (United States)

    2010-09-22

    ... announcing that the docket for formetanate hydrochloride, which was planned for September 2010, has been... hydrochloride, which was planned for September 2010, has been postponed until December 2010. Table 1... (7417) EPA-HQ-OPP-2010-0214 Carissa Cyran, (703) 347-8781, [email protected] Sodium cyanide (8002...

  18. 75 FR 16114 - Registration Review; Biopesticides Dockets Opened for Review and Comment

    Science.gov (United States)

    2010-03-31

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0118; FRL-8816-1] Registration Review; Biopesticides Dockets Opened for Review and Comment AGENCY: Environmental Protection Agency (EPA). ACTION...: March 25, 2010. Keith A. Matthews, Acting Director, Biopesticides and Pollution Prevention Division...

  19. A epilepsia nos tumores cerebrais

    Directory of Open Access Journals (Sweden)

    Luís Marques-Assis

    1969-03-01

    Full Text Available De 411 casos de tumores cerebrais foram estudados 86 (19,4% que apresentaram manifestações epilépticas. A epilepsia foi estudada quanto à duração, ao tipo de manifestação e à severidade, em relação à natureza e à localização dos tumores cerebrais. A análise dos resultados permitiu aos autores chegarem às seguintes conclusões: 1 a epilepsia incidiu em 19,4% dos casos; 2 o oligodendroglioma, as metástases carcinomatosas e o glioblastoma multiforme foram, pela ordem, os tumores mais epileptogênicos; 3 as áreas frontal, parietal e temporal foram, nessa ordem, as localizações mais epileptogênicas; 4 os carcinomas metastáticos predominaram nos casos com epilepsia com menos de um ano de evolução, enquanto que os astrocitomas predominaram nos casos com mais de três anos; quanto à topografia, predominou a região frontal no primeiro grupo e a temporal, no segundo; 5 nas formas mais severas de epilepsia predominaram os oligodendrogliomas e os meningeomas, quanto à natureza, e a região frontotemporal e a foice, quanto à localização; 6 os craniofaringeomas e os meduloblastomas foram os tumores que mais freqüentemente determinaram o aparecimento de convulsões puras; nesses casos, a sela túrsica e a fossa posterior foram as sedes mais freqüentes; 7 os carcinomas metastáticos e os meningeomas, quanto à natureza, e as regiões frontoparietal e parietal, quanto à localização, foram os mais freqüentemente encontrados nos casos com crises de tipo bravais-jacksoniano.

  20. 78 FR 41803 - Establishment of a Public Docket for Comment on the Report Prepared Under the Food and Drug...

    Science.gov (United States)

    2013-07-11

    ... Administration Safety and Innovation Act (FDASIA) Section 1138, enacted July 9, 2012, and posted on the FDA Web... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0757] Establishment of a Public Docket for Comment on the Report Prepared Under the Food and Drug Administration...

  1. 20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Clerk of the Office of the Appellate Boards; docket of proceedings; records. 501.8 Section 501.8 Employees' Benefits EMPLOYEES' COMPENSATION APPEALS BOARD, DEPARTMENT OF LABOR RULES OF PROCEDURE § 501.8 Clerk of the Office of the Appellate Boards; docket of proceedings; records. (a) Location...

  2. Title list, publicly available documents: Three Mile Island Unit 1, Docket 50-289 - cumulated to November 16, 1979

    International Nuclear Information System (INIS)

    1979-01-01

    This title list of publicly available documents pertaining to Three Mile Island Unit 1, Docket 50-289, includes all documents pertaining to this Docket that had been filed in the NRC Public Document Room as of November 16, 1979. The categories used for filing and searching in the NRC Public Document Room are used to catalog the entries

  3. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Science.gov (United States)

    2010-01-01

    ... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive security information. You should not submit sensitive security information to the rulemaking docket, unless you are...

  4. 75 FR 22602 - Front-of-Pack and Shelf Tag Nutrition Symbols; Establishment of Docket; Request for Comments and...

    Science.gov (United States)

    2010-04-29

    ... Obesity Among U.S. Adults,'' 1999 to 2008, Journal of the American Medical Association, 2010;303(3):235... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0210... Information AGENCY: Food and Drug Administration, HHS. ACTION: Notice; establishment of docket; request for...

  5. Final environmental statement related to the operation of North Anna Power Station, Units 1 and 2: (Docket Nos. 50-338 and 50-339)

    International Nuclear Information System (INIS)

    1980-08-01

    The proposed action is the issuance of Operating Licenses to the Virginia Electric and Power Company for the startup and operation of the North Anna Power Station, Units No. 1 and 2, located on Lake Anna in Louisa County, 40 miles east of Charlottesville, Virginia. The information in this second addendum responds to the Commission's directive that the staff address in narrative form the environmental dose commitments and health effects from fuel cycle releases, fuel cycle socioeconomic impacts, and possible cumulative impacts pending further treatment by rulemaking

  6. Safety Evaluation Report related to the operation of Byron Station, Units 1 and 2 (Docket Nos. STN 50-454 and STN 50-455). Supplement No. 7

    International Nuclear Information System (INIS)

    1986-11-01

    Supplement No. 7 to the Safety Evaluation Report related to Commonwealth Edison Company's application for licenses to operate the Byron Station, Units 1 and 2, located in Rockvale Township, Ogle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement provides additional information supporting the license for initial criticality and power ascension to full-power operation for Unit 2

  7. Draft environmental statement related to the operation of Limerick Generating Station, Units 1 and 2. Docket Nos. 50-352 and 50-353

    International Nuclear Information System (INIS)

    1983-06-01

    This Draft Environmental Statement contains the second assessment of the environmental impact associated with the operation of the Limerick Generating Station, Units 1 and 2, pursuant to the National Environment Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs. Land use and terrestrial and aquatic ecological impacts will be small. Operational impacts to historic and archeological sites will be negligible. The effects of routine operations, energy transmission, and periodic maintenance of rights of way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity

  8. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1990-02-01

    Supplement 23 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement reports the status of certain issues that had not been resolved when the Safety Evaluation Report and supplements 1, 2, 3, 4, 6, 12, 21, and 22 to that report were published. This supplement also includes the evaluations for licensing items resolved since Supplement 22 was issued. Supplement 5 has not been issued. Supplements 7, 8, 9, 10, and 11 were limited to the staff evaluation of allegations investigated by the NRC Technical Review Team. Supplement 13 presented the staff's evaluation of the Comanche Peak Response Team (CPRT) Program Plan, which was formulated by the applicant to resolve various construction and design issues raised by sources external to TU Electric. Supplements 14 through 19 presented the staff's evaluation of the CPSES Corrective Action Program: large- and small-bore piping and pipe supports (Supplement 14); cable trays and cable tray hangers (Supplement 15); conduit supports (Supplement 16); mechanical, civil/structural, electrical, instrumentation and controls, and systems portions of the heating, ventilation, and air conditioning (HVAC) system workscopes (Supplement 17); HVAC structural design (Supplement 18); and equipment qualification (Supplement 19). Supplement 20 presented the staff's evaluation of the Comanche Peak Response Team implementation of the CPRT Program

  9. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 18

    International Nuclear Information System (INIS)

    Tam, P.S.

    1995-10-01

    In June 1982, the Nuclear Regulatory Commission staff (NRC staff or staff) issued a Safety Evaluation Report, NUREG-0847, regarding the application by the Tennessee Valley Authority (TVA or the applicant) for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2. Each of the following sections and appendices of this supplement is numbered the same as the section or appendix of the SER that is being updated, and the discussions are supplementary to, and not in lieu of, the discussion in the SER, unless otherwise noted. Accordingly, Appendix A continues the chronology of the safety review. Appendix E lists principal contributors to this supplement. Appendix FF is added in this supplement. The other appendices are not changed by this supplement

  10. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2: Docket Nos. 50-445 and 50-446

    International Nuclear Information System (INIS)

    1988-07-01

    Supplement 15 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Special Projects of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement presents the staff's evaluation of the applicant's Corrective Action Program (CAP) related to the design of cable trays and cable tray hangers. The scope and methodologies for the CAP workscope as summarized in Revision O to the cable tray and cable tray hanger project status report and as detailed in related documents referenced in this evaluation were developed to resolve various design issues raised by the Atomic Safety and Licensing Board (ASLB) the intervenor, Citizens Association for Sound Energy (CASE); the Comanche Peak Response Team (CPRT); CYGNA Energy Services (CYGNA); and the NRC staff. The NRC staff concludes that the CAP workscope for cable trays and cable tray hangers provides a comprehensive program for resolving the associated technical concerns identified by the ASLB, CASE, CPRT, CYGNA, and the NRC staff and its implementation ensures that the design of cable trays and cable tray hangers at CPSES satisfies the applicable requirements of 10 CFR Part 50

  11. Final environmental statement related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499)

    International Nuclear Information System (INIS)

    1986-08-01

    This Final Environmental Statement contains the second assessment of the environmental impact associated with the operation of the South Texas Project, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environmental impacts, environmental consequences and mitigating actions, and environmental and economic benefits and costs associated with station operation. Land use and terrestrial and aquatic ecological impacts will be small. No operational impacts to historic and archeological sites are anticipated. The effects of routine operations, energy transmission, and periodic maintenance of rights-of-way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk of radiation exposure associated with accidental release of radioactivity is very low. Socioeconomic impacts of the project are anticipated to be minimal. The action called for is the issuance of an operating license for South Texas Project, Units 1 and 2

  12. Operation of south Texas Project, Units 1 and 2, Docket Nos. 50-498 and 50-499, Houston Lighting and Power Company et. al., Matagorda County, Texas

    International Nuclear Information System (INIS)

    1986-03-01

    The draft version of the environmental impact statement, EPA No. 860106D, deals with licensing a startup of Units 1 and 2 of the South Texas Project, both pressurized water reactors. The plant will permanently eliminate over 3000 acres of farmland and affect another 6000 acres of neighboring farmland. It will discharge cooling water into the Colorado River. Mitigation plans call for 1700 acres of bottom land to become a wildlife preserve and for no use of herbicides in grazing areas. Positive impacts will be increased employment for the area with a corresponding increase in revenues. Negative impacts may be changes in marsh productivity and species composition. There may be a loss of habitat for the American alligator. Risks associated with the accidental release of radiation are rated as very low. The Federal Water Pollution Control Act of 1972 and Nuclear Regulatory Commission Licensing provide legal mandates

  13. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1988-11-01

    Supplement 18 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Special Projects of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement presents the staff's evaluation of the applicant's Corrective Action Program (CAP) related to the structural design of the heating, ventilation, and air conditioning (HVAC) systems. The scope and methodologies for the CAP workscope as summarized in Revision 0 to the HVAC project status report and as detailed in related documents referenced in this evaluation were developed to resolve the technical concerns identified in the HVAC area. The NRC staff concludes that the CAP workscope for the HVAC structural design provides a comprehensive program for resolving the associated technical concerns and its implementation ensures that the structural design of the HVAC systems at CPSES satisfies the applicable requirements of 10 CFR Part 50. 32 refs

  14. Final environmental statement related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2: (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1981-09-01

    The proposed action is the issuance of operating licenses to the Texas Utilities Generating Company for the startup and operation of Units 1 and 2 of the Comanche Peak Steam Electric Station located on Squaw Creek Reservoir in Somervell County, Texas, about 7 km north-northeast of Glen Rose, Texas, and about 65 km southwest of Fort Worth in north-central Texas. The information in this environmental statement represents the second assessment of the environmental impact associated with the Comanche Peak Steam Electric Station pursuant to the guidelines of the National Environmental Policy Act of 1969 (NEPA) and 10 CFR Part 51 of the Commission's Regulations. After receiving an application to construct this station, the staff carried out a review of impact that would occur during its construction and operation. This evaluation was issued as a Final Environmental Statement -- Construction Phase. After this environmental review, a safety review, an evaluation by the Advisory Committee on Reactor Safeguards, and public hearings in Glen Rose, Texas, the US Atomic Energy Commission (now US Nuclear Regulatory Commission) issued construction permits for the construction of Units 1 and 2 of the Comanche Peak Steam Electric Station. 16 figs., 34 tabs

  15. Report of the South Texas Project Allegations Review Team. Docket Nos. 50-498 and 50-499, Houston Lighting and Power Company et al.

    Energy Technology Data Exchange (ETDEWEB)

    Kokajko, L.; Skay, D.; Wang, H.; Murphy, D. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-03-01

    This report provides the results of the South Texas Project Allegations Review Team of the US Nuclear Regulatory Commission. This team was formed to obtain and review allegations from individuals represented by three attorneys who had contacted Congressional staff members. The allegers were employed in various capacities at South Texas Project Electric Generating Station, licensed by Houston Lighting and Power Company, et al.; therefore, the allegations are confined to this site. The South Texas Project Allegations Review Team reviewed, referred, and dispositioned concerns related to discriminatory issues (harassment and intimidation), falsification of records and omission of information, and various technical issues. The team was able to substantiate certain technical issues of minor safety significance or regulatory concern at the South Texas Project facility, but it did not find widespread discriminatory practices such as harassment and intimidation.

  16. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1990-01-01

    Supplement 22 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station, Units 1 and 2 (NUREG-0797), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplements 1, 2, 3, 4, 6, 12, and 21 to that report. This supplement also includes the evaluations for licensing items resolved since Supplement 21 was issued. Supplement 5 has been cancelled. Supplements 7 through 11 were limited to the staff evaluation of allegations investigated by the NRC Technical Review Team. Supplement 13 presented the staff's evaluation of the Comanche Peak Response Team (CPRT) Program Plan, which was formulated by the applicant to resolve various construction and design issues raised by sources external to the applicant. Supplements 14 through 20 presented the staff's evaluation of the applicant's Corrective Action Program and CPRT activities. Items identified in Supplements 7, 8, 9, 10, 11, 13, 14, and 15 through 20 are not included in this supplement, except to the extent that they affect the applicant's Final Safety Analysis Report. 154 refs., 24 figs., 8 tabs

  17. Safety Evaluation Report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2 (Docket Nos. 50-416 and 50-417). Supplement 6

    International Nuclear Information System (INIS)

    1984-08-01

    Supplement 6 to the Safety Evaluation Report for Mississippi Power and Light Company et al. joint application for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2, located on the east bank of the Mississippi River near Port Gibson in Claiborne County, Mississippi, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the NRC staff's evaluation of open items from previous supplements and Technical Specification changes required before authorizing operation of Unit 1 above 5% of rated power

  18. Technical evaluation report on the seven main transformer failures at the North Anna Power Station, Units 1 and 2 (Docket Nos. 50-338, 50-339)

    International Nuclear Information System (INIS)

    Dalton, K.J.; Kresser, J.V.; Savage, J.W.; Selan, J.C.

    1984-01-01

    This report documents technical evaluations on various aspects pertaining to the seven main transformer failures at the North Anna Power Station, Units 1 and 2. These reports cover the subjects of Probability Risk Assessment (PRA), Failure Modes and Effects Analysis (FMEA), Root Causes, Protection Systems, Modifications, Failure Statistics, and Generic Aspects. The PRA determined that the contribution from a main transformer failure affecting plant safety systems so as to increase the risk to the public health and safety is negligible. The FMEA determined that a main transformer failure can have primary and secondary effects on plant safety system operation. The evaluation of the Root Causes found that no single common cause contributed to the seven failures. Each failure was found to have specific circumstances for initiating the failure. Both the generator and transformer primary protection systems were found to perform correctly and were designed within industry standards and practices. The proposed modifications resulting from the analyses of the failures will improve system reliability and integrity, and will reduce potentially damaging effects. The failure statistic survey found very limited data bases from which a meaningful correlation could be ascertained. The statistical comparison found no appreciable anomalies with the NAPS failures. The evaluation of all the available information and the results of the separate reports on the main transformer failures found that several generic concerns exist

  19. Final environmental statement for William B. McGuire Nuclear Station, Units 1 and 2: (Docket Nos. 50-369 and 50-370)

    International Nuclear Information System (INIS)

    1976-04-01

    The proposed action is the issuance of operating licenses to the Duke Power Company for the startup and operation of the William B. McGuire Nuclear Station, Units 1 and 2 (the plant) located on the Lake Norman in Mecklenburg County, 17 miles north-northwest of Charlotte, North Carolina. The units will be cooled by once-through flow of water from Lake Norman. Two units, each with a net electrical capacity of 1180 MWe will be added to the resources of the Duke Power Company. This will have a favorable effect on reserve margins and provide a cost savings of $77 to $122 million in production costs in 1979 if the units come on line as scheduled, and cost savings in subsequent years. Approximately 200 acres of rural, partially wooded land owned by the applicant will be unavailable for other uses during the 40-year life of the plant. Approximately 61.6 acres of additional land will be utilized for transmission line corridors and/or switchyard and maintained under controlled conditions. Land-use patterns will necessarily conform to the needs of the application but will not be changed significantly from present usage. At full power, condenser cooling water could be heated to as high as 96/degree/F (35.6/degree/C) as a monthly average and will be discharged at a rate of up to 4492 cfs. The temperature rise of the water will be 16/degree/F (8.8/degree/C) to 32/degree/F (17.8/degree/C) above ambient. The heated water will mix with the cooler water of Lake Norman, where the heat will be dissipated to the atmosphere. The increase in temperature will cause a loss of approximately 31 cfs of water as a result of increased evaporation. 26 figs., 46 tabs

  20. Safety Evaluation Report related to the operation of Seabrook Station, Units 1 and 2 (Docket Nos. 50-443 and 50-444)

    International Nuclear Information System (INIS)

    1990-03-01

    This report is Supplement No. 9 to the Safety Evaluation Report (SER) (NUREG-0896, March 1983) for the application filed by the Public Service Company of New Hampshire, et al., for licenses to operate Seabrook Station, Units 1 and 2. It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information on open items identified in the SER. The facility is located in Seabrook, New Hampshire. Subject to favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public. 70 refs., 1 fig., 1 tab

  1. Safety Evaluation Report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353). Supplement No. 5

    International Nuclear Information System (INIS)

    1985-07-01

    In August 1983 the NRC issues its Safety Evaluation Report regarding the application for licenses to operate the Limerick Generating Station, Units 1 and 2 located on a site in Montgomery and Chester Counties, Pennsylvania. Supplement 1 was issued in December 1983 and addressed several outstanding issues. SSER 1 also contains the comments made by the Advisory Committee on Reactor Safeguards in its interim report dated October 18, 1983. Supplement 2 was issued in October 1984. Supplement 3 was issued in October 1984 and addressed the remaining issues that required resolution before issuance of the operating licence for Unit 1. On October 26, 1984 a license (NPF-27) for Unit 1 was issued which was restricted to a five percent power level and contained conditions which required resolution prior to proceeding beyond the five percent power level. Supplement 4 issued in May 1985 addressed some of the technical issues and their associated license conditions, which required resolution prior to proceeding beyond the five percent power level. SSER 4 also contained the comments made by the Advisory Committee on Reactor Safeguards in its report dated November 6, 1984. This Supplement 5 to the SER addresses further issues that require resolution prior to proceeding beyond the five percent power level

  2. Marble Hill Nuclear Generating Station, Units 1 and 2: Final environmental statement (Docket Nos. STN 50-546 and STN 50-547)

    International Nuclear Information System (INIS)

    1976-09-01

    The proposed action is the issuance of construction permits to the Public Service Company of Indiana, Inc., Northern Indiana Public Service Company, Inc., East Kentucky Power Cooperative, Inc., and Wabash Valley Power Association for the construction of the Marble Hill Nuclear Generating Station, Units 1 and 2 (MH 1and2). The 987-acre site is predominately forest and cropland. Construction-related activities on the site would disturb about 250 acres. The portion of this land not be used for the plant facilities, parking lots, roads, etc., will be restored by seeding and landscaping. The temporary removal of vegetation will tend to promote erosion. Increased siltation and turbidity can be expected in local streams during construction, but measures will be taken to minimize these effects. A maximum of 69 cfs of cooling water will be withdrawn from the Ohio River of which cfs will be returned to the river via pipeline with the dissolved solids concentration increased by a factor of about 6. About cfs will be evaporated to the atmosphere by the cooling towers. The volume of discharge (9 cfs) is very small compared with the river flow (annual mean is about 110,000 cfs) and the thermal effect on the river ecosystem is not expected to be significant. Chemical discharges from the plant will be diluted to concentrations below those which might adversely affect aquatic biota. The risk associated with accidental radiation exposure will be very low. 43 figs., 115 tabs

  3. Safety Evaluation Report related to the operation of Byron Station, Units 1 and 2 (Dockets Nos. STN 50-454 and STN 50-455)

    International Nuclear Information System (INIS)

    1984-10-01

    Supplement No. 5 to the Safety Evaluation Report related to Commonwealth Edison Company's application for licenses to operate the Byron Station, Units 1 and 2, located in Rockvale Township, Ogle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report. Because of the favorable resolution of the items discussed in this report, the staff concludes that there is reasonable assurance that the facility can be operated by the applicant without endangering the health and safety of the public

  4. Safety Evaluation Report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353). Supplement 3

    International Nuclear Information System (INIS)

    1984-10-01

    In August 1983 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0991) regarding the application of the Philadelphia Electric Company (the applicant) for licenses to operate the Limerick Generating Station, Units 1 and 2. Supplement 1 was issued in December 1983 and addressed several outstanding issues. Supplement 1 also contains the comments made by the Advisory Committee on Reactor Safeguards in its report dated October 18, 1983. Supplement 2 was issued in October 1984 and addressed fourteen outstanding and fifty-three confirmatory issues and closed them put. This Supplement 3 addresses the remaining issues that require resolution before issuance of the operating license for Unit 1 and closes them out

  5. Safety Evaluation Report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2 (Docket Nos. 50-416 and 50-417). Supplement No. 5

    International Nuclear Information System (INIS)

    1984-08-01

    Supplement 5 to the Safety Evaluation Report for Mississippi Power and Light Company, et al., joint application for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2, located on the east bank of the Mississippi River near Port Gibson in Claiborne County, Mississippi, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status on the resolution of those issues that require further evaluation before authorizing operation of Unit 1 above 5% of rated power

  6. Safety Evaluation Report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353). Supplement No. 4

    International Nuclear Information System (INIS)

    1985-05-01

    In August 1983 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0991) regarding the application of the Philadelphia Electric Company (the applicant) for licenses to operate the Limerick Generating Station, Units 1 and 2 located on a site in Montgomery and Chester Counties, Pennsylvania. A license (NPF-27) for the operation of Limerick Unit 1 was issued on October 26, 1984. The license, which was restricted to a five percent power level, contained conditions which required resolution prior to proceeding beyond the five percent power level. This Supplement 4 to the SER addresses some of those technical issues and their associated license conditions which require resolution prior to proceeding beyond the five percent power level. The remaining issues to be addressed prior to proceeding beyond the five percent power level will be addressed in a later supplement to this report. This Supplement 4 to the SER also contains the comments made by the Advisory Committee on Reactor Safeguards in its report dated November 6, 1984, regarding full power operation of Limerick Unit 1

  7. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1990-04-01

    Supplement 24 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement reports the status of certain issues that had not been resolved when the Safety Evaluation Report and Supplements 1, 2, 3, 4, 6, 12, 21, 22, and 23 to that report were published. This supplement also includes the evaluations for licensing items resolved since Supplement 23 was issued. Supplement 5 has not been issued. Supplements 7, 8, 9, 10, and 11 were limited to the staff evaluation of allegations investigated by the NRC Technical Review Team. Supplement 13 represented the staff's evaluation of the Comanche Peak Response Team (CPRT) Program Plan, which was formulated by the applicant to resolve various construction and design issues raised by sources external to TU Electric. Supplements 14 through 19 presented the staff's evaluation of the CPSES Corrective Action Program: large- and small-bore piping and pipe supports (Supplement 14); cable trays and cable tray hangers (Supplement 15); conduit supports (Supplement 16); mechanical, civil/structural, electrical, instrumentation and controls, and systems portions of the heating, ventilation, and air conditioning (HVAC) system workscopes (Supplement 17); HVAC structural design (Supplement 18); and equipment qualification (Supplement 19). Supplement 20 presented the staff's evaluation of the CPRT implementation of its Program Plan and the issue-specific action plans, as well as the CPRT's investigations to determine the adequacy of various types of programs and hardware at CPSES

  8. Draft Environmental Statement related to the operation of Vogtle Electric Generating Plant, Units 1 and 2 (Docket Nos. 50-424 and 50-425)

    International Nuclear Information System (INIS)

    1984-10-01

    This Draft Environmental Statement contains an assessment of the environmental impact associated with the operation of the Vogtle Electric Generating Plant, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, part 51 (10 CFR 51), as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environmental impacts, environmental consequences and mitigating actions, and environmental and economic benefits and costs associated with station operation

  9. Final environmental statement related to the operation of Byron Station, Units 1 and 2 (Docket Nos. STN 50-454 and STN 50-455)

    International Nuclear Information System (INIS)

    1982-04-01

    The proposed action is the issuance of an operating license to Commonwealth Edison Company (CECo) of Chicago, Illinois, for startup and operation of the Byron Station, Units 1 and 2 on a 710-ha (1754-acre) site in Ogle County 6 km (4 miles) south-southwest of Byron, Illinois, and 3 km (2 miles) east of the Rock River. Each of the two generating units consists of a pressurized-water reactor, four steam generators, one steam turbine generator, a heat-dissipation system, and associated auxiliary and engineered safeguards. Information is presented under the following topics: purpose and need for the action; alternatives to the proposed action; project description and affected environment; environmental consequences and mitigating actions; evaluation of the proposed action; list of contributors; list of agencies and organizations requested to comment on the draft environmental statement; and responses to comments on the Draft Environmental Statement

  10. Safety evaluation report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353)

    International Nuclear Information System (INIS)

    1989-06-01

    In August 1983 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0991) regarding the application of the Philadelphia Electric Company (the licensee) for licenses to operate the Limerick Generating Station, Units 1 and 2, located on site in Montgomery and Chester Counties, Pennsylvania. Supplement 1 to NUREG-0991 was issued in December 1983. Supplements 2 and 3 were issued in October 1984. License NPF-27 for the low-power operation of Limerick Unit 1 was issued on October 26, 1984. Supplement 4 was issued in May, 1985, Supplement 5 was issued in July 1985, and Supplement 6 was issued in August 1985. These supplements addressed further issues that required resolution before Unit 1 proceeded beyond the 5-percent power level. The full-power operating license for Limerick Unit 1 (NPF-39) was issued August 8, 1985, and the unit has completed two cycles of operation. Supplement 7 was issued April 1989 to address some of the few significant design differences between Units 1 and 2, the resolution of issues that remained open when the Unit 1 full-power license was issued and an assessment of some of the issues that required resolution before issuance of an operating license for Unit 2. This supplement addresses the remaining issues that required resolution before issuance of and operating license for Unit 2

  11. Safety evaluation report related to the operation of Limerick Generating Station, Units 1 and 2, Docket nos. 50-352 and 50-353

    International Nuclear Information System (INIS)

    1989-08-01

    In August 1983 the staff of the Nuclear Regulatory commission issued its Safety Evaluation Report (NUREG-0991) regarding the application of the Philadelphia Electric Company (the licensee) for the licenses to operate the Limerick Generating Station, Units 1 and 2, located on a site in Montgomery and Chester Counties, Pennsylvania. Supplement 1 was issued in December 1983. Supplement 2 was issued in October 1984. Supplement 3 was issued in October 1984. Supplement 4 was issued in May 1985. Supplement 5 was issued in July 1985. Supplement 6 was issued in August 1985 and Supplement 7 was issued in April 1989. Supplement 7 addresses the major design differences between Units 1 and 2, the resolution of all issues that remained open when the Unit 1 full-power license was issued, the staff's assessment regarding the application by the licensee to operate Unit 2 and issues that require resolution before issuance of an operating license for Unit 2. Supplements 8 and 9 address further issues that require resolution prior to issuance of an operating license. 1 tab

  12. Final environmental statement related to the operation of Midland Plant, Units 1 and 2. Docket Nos. 50-329 and 50-330, Consumers Power Company

    International Nuclear Information System (INIS)

    1982-07-01

    This final environmental statement contains the second assessment of the environmental impact associated with operation of the Midland Plant, Units 1 and 2 pursuant to the National Environmental Policy Act of 1969 (NEPA) and 10 CFR Part 51, as amended, of the NRC's regulations. This statement examines: the purpose and need for the Midland project, alternatives to the project, the affected environment, environment consequences and mitigating actions, and environmental and economic benefits and costs

  13. Draft environmental statement related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. STN 50-456 and STN 50-457)

    International Nuclear Information System (INIS)

    1983-12-01

    The Draft Environment Statement contains the second assessment of the environmental impact associated with the operation of Braidwood Station, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs. Land use and terrestrial and aquatic ecological impacts will be small. Operational impacts to historic and archeologic sites will be negligible. The effects of routine operations, energy transmission, and periodic maintenance of rights of way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk of radiation exposure associated with accidental release of radioactivity is very low. The net socioeconomi effects of the project will be beneficial. On the basis of the analysis and evaluation set forth in this environmental statement, it is concluded that the action called for under NEPA and 10 CFR 51 is the issuance of operating licenses for Braidwood Station, Units 1 and 2

  14. Palo Verde Nuclear Generating Station Units 1, 2, and 3: Draft environmental statement (Docket Nos. STN 50-528, 529, and 530)

    International Nuclear Information System (INIS)

    1975-04-01

    The proposed action is the issuance of construction permits to the Arizona Public Service Corporation for the construction of the Palo Verde Nuclear Generating Station, Units 1, 2 and 3. Preparation of the 3880-acre site will involve the clearing of up to 2500 acres of land, 1500 of which will be permanently devoted to station facilities. An additional 1200- to 1300-acre evaporation pond will ultimately be developed during the lifetime of the station. About 2200 site acres, previously devoted to agriculture, will be excluded from this land use (Sec. 4. 1). Soil disturbance during construction of the station, transmission lines, and water conveyance pipeline will tend to promote erosion and increase siltation in local ephemeral water courses. Stringent measures will be taken to minimize these effects (Sec. 4.5). Station, transmission line, and water pipeline construction will kill, remove displace, or otherwise disturb involved flora and fauna, and will eliminate varying amounts of wildlife breeding, nesting, and forage habitat. These will not be important impacts to the population stability and structure of the involved local ecosystems of the Sonoran desert; however, measures will be taken to minimize such effects (Sec. 4.3 and 4.5). Approximately 60 acres of agricultural land will be temporarily affected by construction in transmission corridors. The great majority can be returned to that use upon completion of construction, thus the impact is considered minor. Similarly, most grazing lands affected along these corridors, as well as along the water pipeline corridor, can eventually be returned to that use. New archaeological resources could be discovered along the path of final transmission corridor alignments. The applicant will take measures to locate and protect such resources if they exist. 75 refs., 24 figs., 65 tabs

  15. Draft environmental statement related to the proposed Jamesport Nuclear Power Station, Units 1 and 2: (Docket Nos. STN-50-516 and STN-50-517)

    International Nuclear Information System (INIS)

    1975-02-01

    The proposed action is the issuance of construction permits to the Long Island Lighting Company for the construction of the Jamesport Nuclear Power Station, Units 1 and 2, located on Long Island Sound in the Town of Riverhead, New York. Operation of the proposed once-through cooling system will result in the heating of 4180 cfs of water by 18/degree/F. Phytoplankton, zooplankton, and ichthyoplankton will be entrained by the cooling system. The organisms in approximately 40 /times/ 10 9 ft 3 of water per year will suffer direct mortality due to chlorination and heat shock. The risk associated with accidental radiation exposure will be very low. A bottom area of some 105.5 acres will be affected by dredging and jetty construction. Of this total, 4.35 acres will be permanently replaced by jetties, and 101.15 acres will be temporarily (a total of four years) disrupted by dredging. This impact will be temporary, since the dredged areas will be recolonized by the benthic community upon completion of work. There is a potential for substantial impingement loss of fishes on the intake screens which will require additional data to quantify. Approximately 39 miles of transmission lines will be constructed. Ninety-two percent of the total routings utilize existing rights-of-way, railroad rights-of-way, or new rights-of-way immediately adjacent to railroad rights-of-way. The rights-of-way will require approximately 621 acres. 65 refs., 64 tabs

  16. Alan R. Barton Nuclear Plant Units 1, 2, 3 and 4: Draft environmental statement (Docket Nos. 50-524, 525, 526 and 527)

    International Nuclear Information System (INIS)

    1975-04-01

    The proposed action is the issuance of construction permits to the Alabama Power Company for the construction of the Alan R. Barton Nuclear Plant Units 1, 2, 3 and 4. The Barton Plant, located on the Coosa River in Chilton and Elmore Counties, Alabama, will employ boiling water reactors to produce up to 3579 megawatts thermal (MWt) from each unit. A steam turbine-generator will use the heat to provide 1159 MWe (net) of electrical power capacity. A stretch power level of 3758 MWt (1209 MWe) is anticipated from design data and is considered in the assessments contained in this statement. The exhaust steam will be cooled in a closed cycle mode by mechanical cooling towers with water from the Coosa River. Construction of the plant and adjacent facilities will disturb an area of about 1025 acres. the land presently consists of forest land and some cropland. The impact is considered minor. About 18,460 acres will be required for the transmission line routes. The land presently consists of forest, pasture and cropland. No unique land usage is involved in the routes selected. The impacts are considered minor. Station construction will involve some community impacts. Highway congestion, due to increased traffic associated with construction and commuting activities, will have a moderate adverse impact on the local area. The number of construction workers moving into the area is expected to place a strain on the local school systems, housing and community services. Noise, dust, and odor during construction will have a minor adverse effect upon nearby residents in the sparsely populated area. 125 refs., 25 figs., 56 tabs

  17. Final environmental statement related to the proposed construction of Douglas Point Nuclear Generating Station, Units 1 and 2: (Docket Nos. 50-448 and 50-449)

    International Nuclear Information System (INIS)

    1976-03-01

    The proposed action is the issuance of construction permits to the Potomac Electric Power Company for the construction of the Douglas Point Nuclear Generating Station, Units 1 and 2, located in Charles County, Maryland. The exhaust steam will be cooled via a closed-cycle mode incorporating natural-draft wet cooling towers. The water used in the cooling system will be obtained from the Potomac River. Construction-related activities on the site will convert about 290 acres of the 1390 acres of forested land at the Douglas Point site to industrial use. In addition to acreage at the site, approximately 4.5 miles of transmission corridor will require about 211 acres of land for rights-of-way. This corridor will connect with 27 miles of existing rights-of-way over which a line connecting Possum Point to Burches Hill has already been approved. The installation of new transmission line, uniquely identified with Douglas Point, along the existing right-of-way will involve approximately 464 additional acres. As described in the application, the maximum river water intake will be about 97,200 gpm. Of this, a maximum of about 28,000 gpm will be lost in drift or evaporation from the cooling towers. About 700 gpm maximum of fresh well water will be consumed. It is conservatively assumed that all aquatic organisms entrained in the service water system will be killed due to thermal and mechanical shock. It is further estimated that at 97,200 gpm maximum total river water intake, the maximum impact on the striped bass fishery will be a reduction of <5%. The risk associated with accidental radiation exposure is very low. 32 figs., 59 tabs

  18. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2: Docket Nos. 50-390 and 50-391

    International Nuclear Information System (INIS)

    1982-09-01

    Additional information is presented concerning the seismic and dynamic qualification of Seismic Category 1 mechanical and electrical equipment; steam generators; physical security plan; and report to the Advisory Committee on Reactor Safeguards

  19. Final environmental statement related to the operation of Braidwood Station, Units 1 and 2 (Docket Nos. STN 50-456 and STN 50-457)

    International Nuclear Information System (INIS)

    1984-06-01

    This Final Environmental Statement contains the second assessment of the environmental impact associated with the operation of Braidwood Station, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs. Land use and terrestrial and aquatic ecological impacts will be small. Operational impacts to historic and archeologic sites will be moderate. The effects of routine operations, energy transmission, and periodic maintenance of rights of way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk of radiation exposure associated with accidental release of radioactivity is very low. The net socioeconomic effects of the project will be beneficial. On the basis of the analysis and evaluation set forth in this environmental statement, it is concluded that the action called for under NEPA and 10 CFR 51 is the issuance of operating licenses for Braidwood Station, Units 1 and 2. 27 figures, 23 tables

  20. Perkins Nuclear Station, Units 1, 2, and 3: Final environmental statement (Docket Nos. STN 50-488, STN 50-489, and STN 50-490

    International Nuclear Information System (INIS)

    1975-10-01

    The proposed action is the issuance of a construction permit to the Duke Power Company for the construction of the Perkins Nuclear Station (PNS) Units 1, 2, and 3 located in Davie County, North Carolina. A total of 2402 acres will be used for the PNS site; another 1401 acres will be used for the Carter Creek Impoundment. Construction-related activities on the primary site will disturb about 617 acres. Approximately 631 acres of land will be required for transmission line right-of-way, and a railroad spur will affect 77 acres. This constitutes a minor local impact. The heat dissipation system will require a maximum water makeup of 55,816 gpm, of which 50,514 gpm will be consumed due to drift and evaporative losses. This amount represents 4% of the mean monthly flow of the Yadkin River. The cooling tower blowdown and chemical effluents from the station will increase the dissolved solids concentration in the Yadkin River by a maximum of 18 ppm. The thermal alterations and increases in total dissolved solids concentration will not significantly affect the aquatic productivity of the Yadkin River. 26 figs., 51 tabs

  1. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2. Docket Nos. 50-390 and 50-391, Tennessee Valley Authority

    International Nuclear Information System (INIS)

    1982-06-01

    Information is presented concerning site characteristics; design criteria; reactor coolant system and connected systems; engineered safety systems; instrumentation and controls; electric power systems; auxiliary systems; steam and power conversion system; radioactive waste system; radiation protection; conduct of operations; accident analysis; and quality assurance

  2. Washington Public Power Supply System Nuclear Projects 3 and 5 (Docket Nos. STN 50-508 and 50-509): Final environmental statement

    International Nuclear Information System (INIS)

    1975-06-01

    The proposed action is the issuance of construction permits to the Washington Public Power Supply System for the construction of the Washington Nuclear Projects 3 and 5 (WNP 3 and 5). The 2170-acre site is predominately forest. Construction-related activities on the site would disturb about 300 acres. The portion of this land not to be used for the plant facilities, parking lots, roads, etc., will be restored by seeding and landscaping. The temporary removal of vegetation will tend to promote erosion. Increased siltation and turbidity can be expected in local rivers and streams during construction, but stringent measures will be undertaken to minimize these effects. A maximum of 72.5 cfs of cooling water will be withdrawn from the Chehalis River of which 12.5 cfs will be returned to the river via pipeline with the dissolved solids concentration increased by a factor of about 6. About 60 cfs will be evaporated to the atmosphere by the cooling towers. Minor and temporary impacts to the biota of the river and its south bank will result from construction activities. The volume of thermal discharge (12.5 cfs) is small compared with the river flow (annual mean is about 6600 cfs) and the effect on the river ecosystem is not expected to be significant. Chemical discharges from the plant, including chlorine, will be diluted to concentrations below those which might adversely affect aquatic biota. The risk associated with accidental radiation exposure will be very low. 37 figs., 58 tabs

  3. Revised draft environmental statement related to construction of Atlantic Generating Station Units 1 and 2 (Docket Nos. STN 50-477 and STN 50-478)

    International Nuclear Information System (INIS)

    1976-10-01

    The proposed action is the issuance of a construction permit to Public Service Electric and Gas Company (PDE and G) for the construction of the Atlantic Generating Station (AGS), Units 1 and 2. The AGS is the first nuclear power station in the United States proposed for construction in the offshore waters on the continental shelf. The AHS will be located in the Atlantic Ocean 2.8 miles offshore of Atlantic and Ocean countries. New Jersey, 11 miles northeast of Atlantic City, and will consist of two floating nuclear power plants enclosed in a protective rubble-mound breakwater. Both plants will be identical, of standardized design, and will employ pressurized water reactors to produce up to approximately 3425 megawatts thermal (MWt) each. Steam turbine generators will use this heat to produce up to approximately 1150 megawatts of electrical power (MWe) per unit. The main condensers will be cooled by the flow of seawater drawn from within the breakwater and discharged shoreward and external to the breakwater. This statement identifies various environmental aspects and potential adverse effects associated with the construction and operation of the AGS. Based upon an approximate two-year review period which included a multidisciplined assessment of extensive survey and modeling data, these effects are considered by the staff to be of a generally acceptable nature. Breakwater construction will result in the destruction of 100 acres of benthic infauna (burrowing animals) and the development of a reef-type community on the breakwater. The production of new biomass (standing crop) by the reef community is expected to compensate for the infaunal biomass destroyed by dredging and will contribute mainly to the local sport fishery. 93 figs., 110 tabs

  4. Palo Verde Nuclear Generating Station, Units 1, 2 and 3 (Docket Nos. STN 50-528, STN 50-529 and STN 50-530): Final environmental statement

    International Nuclear Information System (INIS)

    1975-09-01

    The proposed action is the issuance of construction permits to the Arizona public Service Company for the construction of the Palo Verde Nuclear Generating Station, Units 1, 2, and 3. Preparation of the 3800-acre site will involve the clearing of up to 2500 acres of land, 1500 of which will be prominently devoted to station facilities. An additional 1200- to 1300-acre evaporation pond will ultimately be developed during the lifetime of the station. About 2200 site acres, previously devoted to agriculture, will be excluded from this land use. Soil disturbance during construction of the station, transmission lines, and water conveyance pipeline will tend to promote erosion and increase siltation in local ephemeral water courses. Stringent measures will be taken to minimize these effects. The total radiation dose to construction workers is estimated to be 15 man-rem. This dose is a small fraction of the approximately 470 man-rem which will be received by the construction force over the same period from natural background radiation. Station, transmission line, and water pipeline construction will kill, remove, displace, or otherwise disturb involved flora and fauna, and will eliminate varying amounts of wildlife breeding, nesting, and forage habitat. These will not be important permanent impacts to the population stability and structure of the involved local ecosystems of the Sonoran desert; however, measures will be taken to minimize such effects as do result form the proposed action

  5. Safety evaluation report related to the operation of Susquehanna Steam Electric Station, Units 1 and 2 (Docket Nos. 50-387 and 50-388). Suppl.6

    International Nuclear Information System (INIS)

    1984-03-01

    In April 1981, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0776) regarding the application of the Pennsylvania Power and Light Company (the applicant and/or licensee) and the Allegheny Electric Cooperative, Inc. (co-applicant) for licenses to operate the Susquehanna Steam Electric Station, Units 1 and 2, located on a site in Luzerne County, Pennsylvania. This supplement to NUREG-0776 addresses the remaining issues that required resolution before licensing operation of Unit 2 and closes them out

  6. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1985-10-01

    This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplements 1, 2, 3, 4, and 6 to that report. This supplement also lists the new issues that have been identified since Supplement 6 was issued and includes the evaluations for licensing items resolved in this interim period. Supplement 5 has not been issued. Supplements 7, 8, 9, 10, and 11 were limited to the staff evaluations of allegations investigated by the NRC Technical Review Team, and items identified therein are not included in this supplement

  7. Safety Evaluation Report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353). Supplement No. 6

    International Nuclear Information System (INIS)

    1985-08-01

    In August 1983 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0991) regarding the application of the Philadelphia Electric Company (the licensee) for licenses to operate the Limerick Generating Station, Units 1 and 2, located on a site in Montgomery and Chester Counties, Pennsylvania. A license for the operation of Limerick Unit 1 was issued on October 26, 1984. The license, which was restricted to a five percent power level, contained conditions which required resolution prior to proceeding beyond the five percent power level. Supplement 4, issued in May 1985, addressed some of these issues. Supplement 4 also contained the comments made by the Advisory Committee on Reactor Safeguards in its report dated November 6, 1984, regarding full power operation of Limerick Unit 1. Supplement 5, issued in July 1985, and this Supplement 6 address further issues, principally the status of offsite emergency planning, that require resolution prior to proceeding beyond the five percent power level

  8. Safety-Evaluation Report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2. Docket Nos. 50-416 and 50-417

    International Nuclear Information System (INIS)

    1983-05-01

    Supplement 4 to the Safety Evaluation Report for Mississippi Power and Light Company, et. al., joint application for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2, located on the east bank of the Mississippi River near Port Gibson in Claiborne County, Mississippi, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status on the resolution of those issues that required further evaluation before authorizing operation of Unit 1 above 5% rated power and other issues that were to be evaluated during the first cycle of power operation

  9. Safety Evaluation Report related to the operation of Limerick Generating Station, Units 1 and 2 (Docket Nos. 50-352 and 50-353). Supplement 2

    International Nuclear Information System (INIS)

    1984-10-01

    In August 1983 the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0991) regarding the application of the Philadelphia Electric Company (the applicant) for licenses to operate the Limerick Generating Station, Units 1 and 2, located on a site in Montgomery and Chester Counties, Pennsylvania. This supplement addresses further issues that require resolution and closes them out

  10. Final Environmental Statement related to the operation of Shearon Harris Nuclear Power Plant, Units 1 and 2 (Docket Nos. STN 50-400 and STN 50-401)

    International Nuclear Information System (INIS)

    1983-10-01

    This Final Environmental Statement contains the second assessment of the environmental impact associated with the operation of the Shoran Harris Nuclear Power Plant, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and 10 CFR 51, as amended, of the NRC regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental economic benefits and costs. Land use and terrestrial and aquatic-ecological impacts will be small. Operational impacts to historic and archaeological sites will be negligible. The effects of routine operations, energy transmission, and periodic maintenance of rights-of-way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk of radiation exposure associated with accidental release of radioactivity is very low. The net socioeconomic effects of the project will be beneficial. 19 figs., 21 tabs

  11. Safety Evaluation Report, related to the operation of Byron Station, Units 1 and 2 (Docket Nos. STN 50-454 and STN 50-455)

    International Nuclear Information System (INIS)

    1983-11-01

    Supplement No. 3 to the Safety Evaluation Report related to Commonwealth Edison Company's application for licenses to operate the Byron Station, Units 1 and 2, located in Rockvale Township, Ogle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

  12. Draft environmental statement related to the operation of Shearon Harris Nuclear Power Plant, Units 1 and 2. Docket Nos. STN 50-400 and STN 50-401

    International Nuclear Information System (INIS)

    1983-04-01

    This Draft Environmental Statement contains the second assessment of the environmental impact associated with the operation of the Shearon Harris Nuclear Power Plant, Units 1 and 2, pursuant to the National Environmental Policy Act of 1979 (NEPA) and 10 CFR 51, as amended, of the NRC regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs. Land use and terrestrial and aquatic-ecological impacts will be small. Operational impacts to historic and archeological sites will be negligible. The effects of routine operations, energy transmission, and periodic maintenance of rights-of-way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk of radiation exposure associated with accidental release of radioactivity is very low. The net socio-economic effects of the project will be beneficial. The action called for is the issuance of an operating license for Shearon Harris PLant, Units 1 and 2

  13. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1988-11-01

    Supplement 19 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Special Projects of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement presents the staff's evaluation of the Texas Utilities Electric Company's (lead applicant's) corrective action program (CAP) related to equipment qualification. The scope and methodology for the CAP workscope, as summarized in Revision 0 to the Equipment Qualification Project Status Report and as detailed in related documents, were developed to resolve various issues raised by the Comanche Peak Response Team (CPRT) and the NRC staff to ensure that plant equipment is appropriately environmentally and/or seismically and dynamically qualified and documented in accordance with the validated plant design resulting from other CAP scopes of work for Unit 1 and areas common to Units 1 and 2. The staff concludes that the CAP workscope for equipment qualification provides a comprehensive program for resolving the concerns identified by the CPRT and the NRC staff, including issues raised in the Comanche Peak Safety Evaluation Report and its supplements, and its implementation will ensure that the environmental and/or seismic and dynamic qualification of equipment at CPSES satisfies the validated plant design and the applicable requirements of 10 CFR Part 50. As is routine staff practice, the NRC staff will verify the adequacy of implementation of the environmental and seismic and dynamic equipment qualification program at CPSES during inspections that will take place before fuel loading. 97 refs

  14. Midland Plant, Units 1 and 2 (Docket Nos. 50-329 and 50-330): Draft supplement to the Final environmental statement

    International Nuclear Information System (INIS)

    1977-01-01

    The Midland Plant, Units 1 and 2 is to be owned and operated by the Consumers Power Company of Michigan. The approximately 1190-acre plant is on the south of the Tittabawassee River immediately across from the Dow Chemical Company's main industrial complex which is within the Midland city limits. The site itself was, and the area south of the site is, partially wooded flat land with farming the only economically significant human activity. To the east and north within one mile of the site, the land is industrial, both developed and undeveloped. To the west, the land is used for suburban residences and light farming. The plant will utilize two pressurized-water nuclear reactor systems. The Consumers Power Company filed with AEC (now NRC) an application for construction permits and operating licenses for the Midland Plant on January 13, 1969. The Final Environmental Statement was issued in March 1972 and on December 15, 1972 construction permits were issued for the Midland Plant. On July 21, 1976, the US Court of Appeals for the District of Columbia Circuit handed down decisions in the generic fuel cycle rulemaking and Midland appeals ruling that nuclear waste disposal and fuel reprocessing issues had been insufficiently considered by the AEC. In addition to consideration of the fuel cycle issues, the Court of Appeals remanded Consumer Power's construction permits for Midland to the NRC for further proceedings to consider energy conservation as an alternative to plant construction, and to consider any changed circumstances concerning the need of Dow for the process steam from the Midland Plant. 10 refs., 13 tabs

  15. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1988-03-01

    Supplement 14 to the Safety Evaluation Report related to the operation of the Comanche Peak Stam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Special Projects of the US Nuclear Regulatory Commission (NRC). The facility is located in Somerville County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement presents the staff's evaluation of the applicants' Corrective Action Program (CAP0 related to large ans small bore piping and pipe supports. The scope and methodologies for CAP workshop as summarized in revision O to the large and small bore piping project status reports and as detailed in related documents referenced in this evaluation were developed to resolve various design issues raised by the Atomic Safety and Licensing Board (ASLB);the intervenor, Citizens Association for Sound Energy (CASE);the Camanche Peak Response Team (CPRT);SYGNA Energy Services (CYGNA);and the NRC staff. The NRC staff concludes that the CAP workscopes for large and small bore piping provide a comprehensive program for resolving the associated technical concerns identified by the ASLB, CASE, CPRT, CYGNA, and the NRC staff and their implementation ensures that the design of large and small bore piping and pipe supports at CPSES satisfies the applicable requirements of 10 CFR 50

  16. Safety evaluation report related to the operation of Byron Station, Units 1 and 2. Docket Nos. STN 50-454 and STN 50-455

    International Nuclear Information System (INIS)

    1983-01-01

    Supplement No. 2 to the Safety Evaluation Report related to Commonwealth Edison Company's application for licenses to operate the Byron Station, Units 1 and 2, located in Rockvale Township, Ogle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

  17. Report of the South Texas Project Allegations Review Team. Docket Nos. 50-498 and 50-499, Houston Lighting and Power Company et al

    International Nuclear Information System (INIS)

    Kokajko, L.; Skay, D.; Wang, H.; Murphy, D.

    1995-03-01

    This report provides the results of the South Texas Project Allegations Review Team of the US Nuclear Regulatory Commission. This team was formed to obtain and review allegations from individuals represented by three attorneys who had contacted Congressional staff members. The allegers were employed in various capacities at South Texas Project Electric Generating Station, licensed by Houston Lighting and Power Company, et al.; therefore, the allegations are confined to this site. The South Texas Project Allegations Review Team reviewed, referred, and dispositioned concerns related to discriminatory issues (harassment and intimidation), falsification of records and omission of information, and various technical issues. The team was able to substantiate certain technical issues of minor safety significance or regulatory concern at the South Texas Project facility, but it did not find widespread discriminatory practices such as harassment and intimidation

  18. Safety evaluation report related to the construction of Skagit/Hanford Nuclear Project, Units 1 and 2. Docket Nos. STN 50-522 and 50-523

    International Nuclear Information System (INIS)

    1982-12-01

    Supplement 3 to the Safety Evaluation Report for the application filed by Puget Sound Power and Light Company on behalf of itself, the Pacific Power and Light Company, The Washington Water Power Company, and the Portland General Electric Company for construction permits to build the Skagit/Hanford Nuclear Project has been issued by the Office of Nuclear Reactor Regulation of the United States Nuclear Regulatory Commission. This supplement is an evaluation of the site relocation amendment to the Preliminary Safety Analysis Report. The proposed site has been relocated from Skagit County, Washington, to the Department of Energy's Hanford Reservation

  19. Safety Evaluation Report related to the operation of Byron Station, Units 1 and 2 (Docket Nos. STN 50-454 and STN 50-455)

    International Nuclear Information System (INIS)

    1984-05-01

    Supplement No. 4 to the Safety Evaluation Report related to Commonwealth Edison Company's application for licenses to operate the Byron Station, Units 1 and 2, located in Rockvale Township, Ogle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

  20. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1984-11-01

    This supplement reports the status of certain issues that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement 1, 2, 3, and 4 of that report. (Supplement 5, currently in preparation, will document the staff's evaluation findings pertaining solely to an independent design verification, conducted for the applicant by the CYGNA Corporation in late 1983-early 1984, and does not update the status of issues since the release of Supplement 4.)

  1. Draft environmental statement related to construction of Erie Nuclear Plant, Units 1 and 2: (Docket Nos. STN 50-580 and STN 50-581)

    International Nuclear Information System (INIS)

    1977-11-01

    The proposed action is the issuance of construction permits to the Ohio Edison Company, acting on behalf of itself, the Cleveland Electric Illuminating Company, Duquesne Light Company, Pennsylvania Power Company, and the Toledo Edison Company, for the construction of the Erie Nuclear Plant Units 1 and 2, located in Erie County, Ohio. A total of 704 hectares (ha) (1740 acres) will be used for the Erie plant site. Construction-related activities on the primary site will disturb about 223 ha (551 acres). Approximately 641 ha (1584 acres) will be required for transmission line rights-of-way. The 3.86-km (2.4-mile) intake and discharge pipeline land corridor will involve alteration of approximately 13 ha (32 acres) of corridor and 1 ha (2.5 acres) for shore facilities. Also, 3.9 ha (9.6 acres) of lake bottom will be disturbed to provide 15-m-wide (50-ft-wide) trenches and an additional 15-m-wide (50-ft-wide) area for storage of excavated material for subsequent backfill for the 701-m (2300-ft) intake and 579-m (1900-ft) discharge lines. Plant construction will involve some community impacts. No residents will be displaced from the site property. Traffic on local roads will increase due to construction and commuting activities. The influx of construction workers' families (a peak work force of about 2700) is expected to cause no major housing or school problems. It is assumed that aquatic organisms entrained in the circulating water system will be killed due to thermal and mechanical shock. The maximum impact based on the population densities of phytoplankton and zooplankton organisms in the adjacent lake area will be the destruction of 0.1% of the entrainable organisms from the lake water. The entrainment of fish larvae will not constitute a significant impact on the lake fishery. 62 figs., 32 tabs

  2. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2. Docket Nos. 50-445 and 50-446

    International Nuclear Information System (INIS)

    1983-03-01

    Supplement No. 3 to the Safety Evaluation Report (SER) related to the operation of the Comanche Peak Steam electric Station, Units 1 and 2, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. the facility is located in Somervell County, Texas. Subject to favorable resolution of the items identified in this supplement, the staff concludes that the facility can be operated by the applicatn without endangering the health and safety of the public. This document provides the NRC staff's evaluation of the outstanding and confirmatory issues that have been resolved since Supplement No. 2 was issued in January 1982, and addresses changes to the SER and its earlier supplements which have resulted from the receipt of additonal information from the applicant during the period of January throught October 1982

  3. Safety Evaluation Report related to the operation of LaSalle County Station, Units 1 and 2. Docket Nos. 50-373 and 50-374

    International Nuclear Information System (INIS)

    1984-03-01

    This supplement to the Safety Evaluation Report of Commonwealth Edison Company's application for a license to operate its La Salle County Station, Unit 2, located in Brookfield Township, La Salle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement is to update evaluations on Unit 2 issues identified in the previous Safety Evaluation Report and Supplements that need resolution prior to issuance of the full power operating license for Unit 2

  4. Safety evaluation report related to the operation of Byron Station, Units 1 and 2 (Docket Nos. STN 50-454 and STN 50-455)

    International Nuclear Information System (INIS)

    1987-03-01

    Supplement No. 8 to the Safety Evaluation Report related to Commonwealth Edison Company's application for licenses to operate the Byron Station, Units 1 and 2, located in Rockvale Township, Ogle County, Illinois, has been prepared by th Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement provides recent information regarding resolution of the license conditions identified in the SER. Because of the favorable resolution of the items discussed in this report, the staff concludes that the Byron Station, Unit 2 can be operated by the licensee at power levels greater than 5% without endangering the health and safety of the public

  5. Draft environmental statement related to construction of Yellow Creek Nuclear Plant, Units 1 and 2: (Docket Nos. STN 50-566 and STN 50-567)

    International Nuclear Information System (INIS)

    1977-06-01

    The proposed action is the issuance of construction permits to the Tennessee Valley Authority for the construction of the Yellow Creek Nuclear Plant Units 1 and 2. The 470-hectare site is predominantly wooded. Construction-related activities on the site would disturb about 59 hectares. The portion of this land not to be used for plant facilities, parking lots, roads, etc., will be restored by seeding and landscaping. The temporary removal of vegetation will tend to promote erosion. Increased siltation and turbidity can be expected in the Yellow Creek embayment during construction, but measures will be taken to minimize these effects. A maximum of 237.6 m 3 /min of make-up water will be withdrawn from the Yellow Creek embayment, of which 106 m 3 /min will be returned to Pickwick Lake via a pipeline with the dissolved solids concentration increased by a factor of about two. About 106 m 3 /min will be evaporated to the atmosphere by the cooling towers. The volume of thermal discharge (106 m 3 /min) is small compared with the flow in Pickwick Lake (minimum daily average flow of 7812 m 3 /min) and the effect on the Pickwick Lake ecosystem is not expected to be significant. During periods of average flow the plant could use about 24% of the flow through Yellow Creek embayment. Chemical discharges (with the possible exception of copper) from the plant will be diluted to concentrations below those which might adversely affect aquatic biota. The risk associated with accidental radiation exposure will be very low. 42 figs., 100 tabs

  6. Final environmental statement related to construction of Midland Plant, Units 1 and 2 (Docket Nos. 50-329 and 50-330)

    International Nuclear Information System (INIS)

    1977-01-01

    This is a Final Detailed Statement on Environmental Considerations associated with construction and operation of Midland Plant Units 1 and 2 at Midland, Michigan, pursuant to a construction permit and operating license which has been applied for by the Consumers Power Company. The application is under review by the US Atomic Energy Commission's Regulatory Staff. The environmental impact, including adverse and beneficial effects, of the Midland Plant includes reassignment of use of about 1100 acres of agricultural and residential land for the cooling pond (the plant buildings are located on industrial zoned land); this resulted in the dislocation of approximately 25 residences and relocation of the Midland County Farm to a newly built structure; the destruction of a maximum of 4400 tons of phytoplankton per year at the intake of makeup water from the Tittabawassee River; and a predicted small increase in fogging effects in the near vicinity of the cooling pond. 34 refs., 19 figs., 26 tabs

  7. MGE-derived nNOS+ interneurons promote fear acquisition in nNOS-/- mice.

    Science.gov (United States)

    Zhang, Lin; Yuan, Hong-Jin; Cao, Bo; Kong, Cheng-Cheng; Yuan, Fang; Li, Jun; Ni, Huan-Yu; Wu, Hai-Yin; Chang, Lei; Liu, Yan; Luo, Chun-Xia

    2017-12-02

    Neuronal nitric oxide synthase (nNOS) 1 , mainly responsible for NO release in central nervous system (CNS) 2 , plays a significant role in multiple physiological functions. However, the function of nNOS + interneurons in fear learning has not been much explored. Here we focused on the medial ganglionic eminences (MGE) 3 -derived nNOS + interneurons in fear learning. To determine the origin of nNOS + interneurons, we cultured neurons in vitro from MGE, cortex, lateral ganglionic eminence (LGE) 4 , caudal ganglionic eminences (CGE) 5 and preoptic area (POA) 6 . The results showed that MGE contained the most abundant precursors of nNOS + interneurons. Moreover, donor cells from E12.5 embryos demonstrated the highest positive rate of nNOS + interneurons compared with other embryonic periods (E11.5, E12, E13, E13.5 and E14). Additionally, these cells from E12.5 embryos showed long axonal and abundant dendritic arbors after 10 days culture, indicating the capability to disperse and integrate in host neural circuits after transplantation. To investigate the role of MGE-derived nNOS + interneurons in fear learning, donor MGE cells were transplanted into dentate gyrus (DG) 7 of nNOS knock-out (nNOS -/- ) or wild-type mice. Results showed that the transplantation of MGE cells promoted the acquisition of nNOS -/- but not the wild-type mice, suggesting the importance of nNOS + neurons in fear acquisition. Moreover, we transplanted MGE cells from nNOS -/- mice or wild-type mice into DG of the nNOS -/- mice and found that only MGE cells from wild-type mice but not the nNOS -/- mice rescued the deficit in acquisition of the nNOS -/- mice, further confirming the positive role of nNOS + neurons in fear learning. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Neuronal NOS localises to human airway cilia.

    Science.gov (United States)

    Jackson, Claire L; Lucas, Jane S; Walker, Woolf T; Owen, Holly; Premadeva, Irnthu; Lackie, Peter M

    2015-01-30

    Airway NO synthase (NOS) isoenzymes are responsible for rapid and localised nitric oxide (NO) production and are expressed in airway epithelium. We sought to determine the localisation of neuronal NOS (nNOS) in airway epithelium due to the paucity of evidence. Sections of healthy human bronchial tissue in glycol methacrylate resin and human nasal polyps in paraffin wax were immunohistochemically labelled and reproducibly demonstrated nNOS immunoreactivity, particularly at the proximal portion of cilia; this immunoreactivity was blocked by a specific nNOS peptide fragment. Healthy human epithelial cells differentiated at an air-liquid interface (ALI) confirmed the presence of all three NOS isoenzymes by immunofluorescence labelling. Only nNOS immunoreactivity was specific to the ciliary axonemeand co-localised with the cilia marker β-tubulin in the proximal part of the ciliary axoneme. We report a novel localisation of nNOS at the proximal portion of cilia in airway epithelium and conclude that its independent and local regulation of NO levels is crucial for normal cilia function. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Safety evaluation report related to the operation of River Bend Station (Docket No. 50-458)

    International Nuclear Information System (INIS)

    1984-05-01

    The Safety Evaluation Report for the application filed by the Gulf States Utilities Company, as applicant and owner, for a license to operate the River Bend Station (Docket No. 50-458) has been prepared by the Office of Nuclear Reactor Regulation of US Nuclear Regulatory Commission. The facility is located near St. Francisville, Louisiana. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  10. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Numbers 50-390 and 50-391)

    International Nuclear Information System (INIS)

    1994-04-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), and Supplement No. 12 (October 1993), issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items, and proposed license conditions identified in the SER. These issues relate to: Design criteria -- structures, components, equipment, and systems; Reactor; Instrumentation and controls; Electrical power systems; Auxiliary systems; Conduct of operations; Accident analysis; and Quality assurance

  11. Technical specifications, Braidwood Station Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457): Appendix ''A'' to License No. NPF-72, [October 1986-July 1987

    International Nuclear Information System (INIS)

    1987-07-01

    The Braidwood Station, Units 1 and 2, technical specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  12. Final site environmental statement: Blue Hills Station, Unit Nos. 1 and 2. Related to the determination of the suitability of Site G for eventual construction. Docket Nos. 50-510 and 50-511

    International Nuclear Information System (INIS)

    1978-07-01

    The site suitability analysis is based on the assumption that the Blue Hills Station will employ two pressurized water reactors to produce outputs of approximately 2814 MWt each. Two steam turbine generators will use the heat produced to provide approximately 957 MWe (gross) each. The exhaust steam will be cooled by four low-profile round mechanical-draft cooling towers. Assuming construction of a nuclear station at site G, a summary of environmental impacts and adverse effects is presented

  13. NOAA NOS SOS, EXPERIMENTAL, 1902-present, Salinity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have salinity data. *These services are for testing and evaluation use...

  14. NOAA NOS SOS, EXPERIMENTAL, 1902-present, Conductivity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have conductivity data. *These services are for testing and evaluation use...

  15. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    Directory of Open Access Journals (Sweden)

    Jennifer M. Bratt

    2010-01-01

    Full Text Available Objectives and Design. The function of the airway nitric oxide synthase (NOS isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia.

  16. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    Science.gov (United States)

    Bratt, Jennifer M.; Williams, Keisha; Rabowsky, Michelle F.; Last, Michael S.; Franzi, Lisa M.; Last, Jerold A.; Kenyon, Nicholas J.

    2010-01-01

    Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA) aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia. PMID:20953358

  17. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    Science.gov (United States)

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  18. Orthodontic force stimulates eNOS and iNOS in rat osteocytes

    NARCIS (Netherlands)

    Tan, S.D.; Xie, R.; Klein Nulend, J.; van Rheden, R.E.; Bronckers, A.L.J.J.; Kuijpers-Jagtman, A.M.; Von den Hoff, J.W.; Maltha, J.C.

    2009-01-01

    Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these

  19. Orthodontic force stimulates eNOS and iNOS in rat osteocytes.

    NARCIS (Netherlands)

    Tan, S.D.; Xie, R.; Klein-Nulend, J.; Rheden, R.E.M. van; Bronckers, A.L.; Kuijpers-Jagtman, A.M.; Hoff, J.W. Von den; Maltha, J.C.

    2009-01-01

    Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these

  20. Marketing plan NOS: introducing pay per view

    OpenAIRE

    Pereira, Pedro Azeredo

    2016-01-01

    NOS, NOS Comunicações S.A., is a private telecommunications company of the portuguese market which is proud of being the “best communications and entertainment company in the market”. The company was born from a fusion between two of the biggest communications corporations in the country: on the fixed service (TV, fixed phone, fixed internet, etc.) from ZON; and on the mobile service (mobile phone, internet, etc.) from Optimus. It is a leader in all the sectors it operates. Bes...

  1. 76 FR 9612 - GE Hitachi Nuclear Energy; Acceptance for Docketing of an Application for Renewal of the U.S...

    Science.gov (United States)

    2011-02-18

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-045; NRC-2011-0020] GE Hitachi Nuclear Energy... Certification On December 7, 2010, GE Hitachi Nuclear Energy (GEH) submitted an application to the U.S. Nuclear... and Approvals for Nuclear Power Plants.'' A notice of receipt and availability of this application was...

  2. 21 CFR 10.20 - Submission of documents to Division of Dockets Management; computation of time; availability for...

    Science.gov (United States)

    2010-04-01

    ... Management; computation of time; availability for public disclosure. 10.20 Section 10.20 Food and Drugs FOOD... Management; computation of time; availability for public disclosure. (a) A submission to the Division of Dockets Management of a petition, comment, objection, notice, compilation of information, or any other...

  3. Title list publicly available documents: Three Mile Island Unit 2, Docket 50-320. Cumulated to May 21, 1979

    International Nuclear Information System (INIS)

    1979-01-01

    This title list of publicly available documents pertaining to Three Mile Island Unit 2, Docket 50-320, includes those preincident and postincident documents filed in the NRC Public Document Room as of May 21, 1979. It is divided into preincident and postincident listings, with both listings subdivided into the categories used for filing and searching in the NRC Public Document Room

  4. 14 CFR 406.113 - Filing documents with the Docket Management System (DMS) and sending documents to the...

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Filing documents with the Docket Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for... Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for...

  5. The Wm. H. Zimmer Nuclear Power Station: Draft environmental statement (Docket No. 50-358)

    International Nuclear Information System (INIS)

    1976-10-01

    The proposed action is the issuance of an operating license to the Cincinnati Gas and Electric Company, the Columbus and Southern Ohio Electric Company, and the Dayton Power and Light Company for the startup and operation of the Wm. H. Zimmer Nuclear Power Station (Docket No. 50-358) (the station), located on the Ohio River in Clermont County, about 24 miles southeast of Cincinnati, Ohio. The information in this statement represents the second assessment of the environmental impact associated with the Zimmer Nuclear Power Station pursuant to the guidelines of the National Environmental Policy Act of 1969 (NEPA) and 10 CFR Part 51 of the Commission's Regulations. After receipt of an application in 1970 to construct this plant, the staff carried out a review of impact that would occur during the plant's construction and operation. This evaluation was issued as a final environmental statement in September 1972. As the result of this environmental review, a safety review, an evaluation by the Advisory Committee on Reactor Safeguards, and a public hearing in Cincinnati, Ohio, the AEC (now NRC) issued a permit in October 1972 for the construction of Unit 1 of the Zimmer Nuclear Power Station. As of June 1976, the construction of the plant was 54% complete. With a proposed fuel-loading data of April 1978, the applicant has petitioned for license to operate Unit 1 and has submitted (September 1975) the required safety and environmental reports to substantiate this petition. 96 refs., 17 figs., 34 tabs

  6. A Linguagem Motion Graphics nos Videoclipes Brasileiros

    Directory of Open Access Journals (Sweden)

    Herom Vargas

    2013-08-01

    Full Text Available Com o desenvolvimento das tecnologias digitais de edição, animação e pós-produção, a linguagem motion graphics se configurou como ferramenta criativa nas relações entre som e imagem. Este artigo tem como objetivo identificar e analisar aspectos inovadores da utilização da linguagem motion graphics nos videoclipes de artistas brasileiros, no período de 1990 a 2010. Por meio de categorias de avaliação relacionadas 1 aos softwares de composição visual, 2 à evolução da linguagem do clipe no período e 3 às relações entre música, vídeo e gráficos utilizados, quatro estágios de aplicação criativa dos recursos dessa linguagem nos videoclipes brasileiros foram estabelecidos.

  7. ¿Las emociones nos distraen?

    Directory of Open Access Journals (Sweden)

    Antonia Pilar Pacheco-Unguetti

    2014-06-01

    Full Text Available ¿Leerás este artículo hasta el final sin interrupciones? Puede que, mientras lo intentas, recibas algún mensaje de whatsapp, se abra una ventana emergente en tu ordenador con una oferta de viajes al Caribe o el cartero llame dos veces a tu puerta. También puede ser que simplemente no tengas un buen día y te resulte especialmente difícil concentrarte. Vivimos expuestos a multitud de estímulos distractores externos, algunos tan inesperados o extraños que entorpecen irremediablemente nuestra concentración en una tarea (distracción por novedad. Pero la distracción también puede tener una causa interna y cómo nos sentimos puede influir en cuánto nos distraemos.

  8. THE EMOTIONAL PROSODY OF U.S. FATAL AIR-ACCIDENT DOCKETS ONLINE: RISKING RISK COMMUNICATION?

    Directory of Open Access Journals (Sweden)

    Кармен Санчо Гинда

    2018-12-01

    Full Text Available Risk communication is grounded in both rationality and emotion (Fischhoff & Kadvany 2011, Bo-holm & Corvellec 2014. Recent investigations have proved that emotions do affect risk and danger percep-tions by functioning as ‘mediators’ (Xie et al. 2011 and become important in decision-making. My study explores how emotion is induced by the National Transportation Safety Board of the United States of America (NTSB for short to influence the mentalities and behaviours of its broad mixed audience and thus increase risk prevention. With that research purpose in mind, I examine an electronic corpus of over 500 online samples of fatal aviation dockets issued yearly online by the NTSB between the time span 2010-2015 and contained in its website databases. The emotional engagement deployed to mediate the perceptions of risk and danger by the general public constitutes a unique genre among all other world transportation agencies, since through informative vividness it pursues to activate the processes of memory, inference (i.e. judgement and decision-making. I take Stubbs’ (2001 concept of ‘discursive prosody’ as point of departure and resort to a blended theoretical framework that combines Narratology, Corpus Linguistics, Critical Discourse Analysis, and Proximisation (Cap 2013 and Positioning (Harré & van Langenhove 1999 Theories. I will show that the NTSB’s emotional prosody is more rhetorical than lexical and that the narrative strategies of focalisation and speech representation play a salient role. To conclude I will reflect on some of the possible consequences of over-exploiting emotional engagement in risk communication.

  9. Safety evaluation report related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412)

    International Nuclear Information System (INIS)

    1987-03-01

    This report, Supplement No. 4 to the Safety Evaluation Report for the application filed by the Duquesne Light Company et al. (the applicant) for a license to operate the Beaver Valley Power Station, Unit 2 (Docket No. 50-412), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved when the Safety Evaluation Report and its Supplements 1, 2, and 3 were published

  10. Safety evaluation report related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412)

    International Nuclear Information System (INIS)

    1986-05-01

    This report, Supplement No. 1 to the Safety Evaluation Report for the application filed by the Duquesne Light Company et al. (the applicant) for a license to operate the Beaver valley Power Station, Unit 2 (Docket No. 50-412), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time the Safety Evaluation Report was published

  11. Publicly available documents Three Mile Island Unit 2, Docket 50-320. Title list, July 1-October 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    This supplemental title list of publicly available documents pertaining to Three Mile Island Unit 2, Docket 50-320, includes those preincident and postincident documents filed in the NRC Public Document Room between July 1, 1979 and October 31, 1979. It is divided into preincident and postincident listings, with both listings sub-divided into the categories used for filing and searching in the NRC Public Document Room.

  12. Design data and safety features of commercial nuclear power plants. Vol. IV. Dockets 50-452 through 50-503

    International Nuclear Information System (INIS)

    Heddleson, F.A.

    1975-03-01

    Design data, safety features, and site characteristics are summarized for 36 nuclear power units in 18 power stations in the United States. Six pages of data are presented for each plant consisting of thermal-hydraulic and nuclear factors, containment features, emergency-core-cooling systems, site features, circulating water system data, and miscellaneous factors. An aerial perspective is also presented for each plant. The volume covers reactors with dockets 50-452 through 50-503. (U.S.)

  13. Publicly available documents Three Mile Island Unit 2, Docket 50-320. Title list, July 1-October 31, 1979

    International Nuclear Information System (INIS)

    1979-01-01

    This supplemental title list of publicly available documents pertaining to Three Mile Island Unit 2, Docket 50-320, includes those preincident and postincident documents filed in the NRC Public Document Room between July 1, 1979 and October 31, 1979. It is divided into preincident and postincident listings, with both listings sub-divided into the categories used for filing and searching in the NRC Public Document Room

  14. NOS3 Polymorphisms and Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Alejandro Marín Medina

    2018-05-01

    Full Text Available ABSTRACT Chronic kidney disease (CKD is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized by the enzyme nitric oxide synthase, which has 3 isoforms. Polymorphisms in the NOS3 gene have been implicated as factors that alter the homeostasis of this mechanism. The Glu298Asp polymorphisms 4 b/a and -786T>C of the NOS3 gene have been associated with a more rapid deterioration of kidney function in patients with CKD. These polymorphisms have been evaluated in patients with CKD of determined and undetermined etiology and related to a more rapid deterioration of kidney function.

  15. Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation.

    Science.gov (United States)

    Zhang, Jun-Xia; Qu, Xin-Liang; Chu, Peng; Xie, Du-Jiang; Zhu, Lin-Lin; Chao, Yue-Lin; Li, Li; Zhang, Jun-Jie; Chen, Shao-Liang

    2018-05-01

    Uncoupled endothelial nitric oxide synthase (eNOS) produces O 2 - instead of nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O 2 - production. Nevertheless, it is unclear whether autophagy plays a critical role in the regulation of eNOS uncoupling. Therefore, this study aimed to investigate the modulation of autophagy on eNOS uncoupling induced by low SS exposure. We found that low SS induced endothelial O 2 - burst, which was accompanied by reduced NO release. Furthermore, inhibition of eNOS by L-NAME conspicuously attenuated low SS-induced O 2 - releasing, indicating eNOS uncoupling. Autophagy markers such as LC3 II/I ratio, amount of Beclin1, as well as ULK1/Atg1 were increased during low SS exposure, whereas autophagic degradation of p62/SQSTM1 was markedly reduced, implying impaired autophagic flux. Interestingly, low SS-induced NO reduction could be reversed by rapamycin, WYE-354 or ATG5 overexpression vector via restoration of autophagic flux, but not by N-acetylcysteine or apocynin. eNOS uncoupling might be ascribed to autophagic flux blockade because phosphorylation of eNOS Thr495 by low SS or PMA stimulation was also regulated by autophagy. In contrast, eNOS acetylation was not found to be regulated by low SS and autophagy. Notably, although low SS had no influence on eNOS Ser1177 phosphorylation, whereas boosted eNOS Ser1177 phosphorylation by rapamycin were in favor of the eNOS recoupling through restoration of autophagic flux. Taken together, we reported a novel mechanism for regulation of eNOS uncoupling by low SS via autophagy-mediated eNOS phosphorylation, which is implicated in geometrical nature of atherogenesis. Copyright © 2018 Elsevier B.V. All rights reserved.

  16. DOENÇAS DE SUÍNOS

    OpenAIRE

    Juliana Sperotto Brum

    2013-01-01

    Esta tese envolveu o estudo de doenças de suínos, incluindo a descrição de um sarcoma granulocítico eosinofílico e surtos de intoxicação por sal. O estudo das características e frequência das doenças na população suína na região de abrangência do Laboratório de Patologia Veterinária (LPV) da Universidade Federal de Santa Maria (UFSM) foi realizado através de um estudo retrospectivo de todos os diagnósticos de necropsias. Foram separados 564 casos com diagnósticos conclusivos. A...

  17. Renal nerves and nNOS

    DEFF Research Database (Denmark)

    Kompanowska-Jezierska, Elzbieta; Wolff, Helle; Kuczeriszka, Marta

    2008-01-01

    ). This was tested by NaLoad after chronic renal denervation with and without inhibition of nNOS by S-methyl-thiocitrulline (SMTC). In addition, the acute effects of renal denervation on MABP and sodium balance were assessed. Rats were investigated in the conscious, catheterized state, in metabolic cages...... of acutely and chronically denervated rats were less than control (15% and 9%, respectively, P reduced by renal denervation (14.5 +/- 0.2 vs. 19.3 +/- 1.3 mIU/l, P reduced...... PRC (P sodium excretion six-fold, irrespective of renal denervation and SMTC. The metabolic data demonstrated that renal denervation lowered sodium balance during the first days after denervation (P

  18. Safety Evaluation Report related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412)

    International Nuclear Information System (INIS)

    1987-05-01

    This report, Supplement No. 5 to the Safety Evaluation Report for the application filed by the Duquesne Light Company et al. (the applicant) for a license to operate the Beaver Valley Power Station, Unit 2 (Docket No. 50-412), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved when the Safety Evaluation Report and its Supplements 1, 2, 3, and 4 were published

  19. Safety evaluation report related to the operation of Millstone Nuclear Power Station, Unit No. 3 (Docket No. 50-423)

    International Nuclear Information System (INIS)

    1984-07-01

    The Safety Evaluation Report for the application filed by Northeast Nuclear Energy Company, as applicant and agent for the owners, for a license to operate the Millstone Nuclear Power Station Unit 3 (Docket No. 50-423), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in the town of Waterford, New London County, Connecticut, on the north shore of Long Island Sound. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  20. Safety Evaluation Report related to the operation of Hope Creek Generating Station (Docket No. 50-354)

    International Nuclear Information System (INIS)

    1984-10-01

    The Safety Evaluation Report for the application filed by Public Service Electric and Gas Company, as applicant, for a license to operate the Hope Creek Generating Station (Docket No. 50-354), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Salem County, New Jersey. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  1. Safety Evaluation Report related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412)

    International Nuclear Information System (INIS)

    1985-10-01

    This Safety Evaluation Report on the application filed by Duquesne Light Company, as applicant and agent for the owners, for a license to operate the Beaver Valley Power Station Unit 2 (Docket No. 50-412) has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Shippingport Borough, Beaver County, Pennsylvania, on the south bank of the Ohio River. Subject to the favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  2. Safety-Evaluation Report related to the construction of the Clinch River Breeder Reactor Plant. Docket No. 50-537

    International Nuclear Information System (INIS)

    1983-03-01

    The Safety-Evaluation Report for the application by the United States Department of Energy, Tennessee Valley Authority, and the Project Management Corporation, as applicants and owners, for a license to construct the Clinch River Breeder Reactor Plant (docket No. 50-537) has been prepared by the Office of Nuclear Reactor Regulation of the United States Nuclear Regulatory Commission. The facility will be located on the Clinch River approximately 12 miles southwest of downtown Oak Ridge and 25 miles west of Knoxville, Tennessee. Subject to resolution of the items discussed in this report, the staff concludes that the construction permit requested by the applicants should be issued

  3. Safety Evaluation Report related to the operation of Waterford Steam Electric Station, Unit No. 3 (Docket No. 50-382)

    International Nuclear Information System (INIS)

    1985-03-01

    Supplement 10 to the Safety Evaluation Report for the application filed by Louisiana Power and Light Company for a license to operate the Waterford Steam Electric Station, Unit 3 (Docket No. 50-382), located in St. Charles Parish, Louisiana, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing the staff's evaluation of information submitted by the licensee since the Safety Evaluation Report and its nine previous supplements were issued

  4. Safety Evaluation Report related to the operation of WPPSS Nuclear Project No. 2 (Docket No. 50-397)

    International Nuclear Information System (INIS)

    1984-04-01

    This report, Supplement No. 5 to the Safety Evaluation Report (SSER 5) on the Washington Public Power Supply System application for a license to operate WNP-2 (Docket No. 50-397), located in Benton County, Washington, approximately 12 miles north of Richland, Washington, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and Supplements No. 1, 2, 3, and 4

  5. Safety evaluation report related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412)

    International Nuclear Information System (INIS)

    1987-08-01

    This report, Supplement No. 6 to the Safety Evaluation Report for the application filed by the Duquesne Light Company et al. (the licensee) for a license to operate the Beaver Valley Power Station, Unit 2 (Docket No. 50-412), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved when the Safety Evaluation Report and its Supplements 1, 2, 3, 4, and 5 were published

  6. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

    Science.gov (United States)

    Fujii, Naoto; Meade, Robert D; Alexander, Lacy M; Akbari, Pegah; Foudil-Bey, Imane; Louie, Jeffrey C; Boulay, Pierre; Kenny, Glen P

    2016-02-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P exercise protocol (all P exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults. Copyright © 2016 the American Physiological Society.

  7. 76 FR 43997 - N. Stanley Standal and Loretta M. Standal; Lynn E. Stevenson; Notice of Change in Docket Numbers

    Science.gov (United States)

    2011-07-22

    ...; Project Nos. 8866-006 and 8866- 007] N. Stanley Standal and Loretta M. Standal; Lynn E. Stevenson; Notice.... Stevenson to N. Stanley and Loretta M. Standal. Shortly thereafter, on July 20, 2004, the Commission issued... transfer and amendment orders. N. Stanley and Loretta M. Standal are correctly identified as the licensees...

  8. 75 FR 23820 - Notice of Docketing of Amendment Request for Materials License No. SNM-2506; Northern States...

    Science.gov (United States)

    2010-05-04

    ... INFORMATION CONTACT: Pamela Longmire, Ph.D., Project Manager, Licensing Branch, Division of Spent Fuel Storage... Generating Plant (PINGP), Unit Nos. 1 and 2, site in Goodhue County, Minnesota. The TN-40 cask is currently..., higher burnup spent fuel used in the PINGP reactor as well as associated changes to the ISFSI's technical...

  9. Vascular nitric oxide: Beyond eNOS

    Directory of Open Access Journals (Sweden)

    Yingzi Zhao

    2015-10-01

    Full Text Available As the first discovered gaseous signaling molecule, nitric oxide (NO affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC to produce cyclic guanosine monophosphate (cGMP, although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA or production of cyclic inosine monophosphate (cIMP] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.

  10. Draft environmental statement related to the proposed manufacture of floating nuclear power plants (Docket No. STN 50-437)

    International Nuclear Information System (INIS)

    1976-10-01

    The proposed action is the issuance of a manufacturing license to Offshore Power Systems for the startup and operation of a proposed manufacturing facility located at Blount Island, Jacksonville, Florida (Docket No. STN 50-436). No nuclear fuel will be handled or stored at the manufacturing site. The plants will be fueled after they have been towed to and moored within breadwaters at specific offshore locations designated by the purchaser and after an operating license has been issued by the Nuclear Regulatory Commision. Each nuclear generating plant, mounted on a floating platform, has a net capacity of 1150 MWe. This energy is provided by a pressurized water reactor steam supply system consisting of a Westinghouse four-loop 3425 MWt unit with an ice-condenser containment system. When one or more of these units is located within a single breakwater, the installation is designated an offshore power station. 3 figs., 1 tab

  11. NOS CO-OPS Water Level Data, Verified, High Low

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), daily, high low water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services...

  12. NOS CO-OPS Active Currents Data, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has surface Active Currents data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These raw data have not...

  13. NOS CO-OPS Water Level Data, Verified, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  14. NOS CO-OPS Water Level Data, Preliminary, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has recent, preliminary (not quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and...

  15. NOS CO-OPS Meteorological Data, Relative Humidity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Relative Humidity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  16. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Air Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have air temperature data. *These services are for testing and evaluation...

  17. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Barometric Pressure

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have barometric pressure data. *These services are for testing and...

  18. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Water Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have water temperature data. *These services are for testing and evaluation...

  19. NOAA/NOS and USCGS Seabed Descriptions from Hydrographic Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA/NOS and USCGS Seabed Descriptions from Hydrographic Surveys database is a compilation of surficial sediment composition from multiple sources for over...

  20. NOS CO-OPS Water Level Data, Verified, Hourly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), hourly, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  1. NOS CO-OPS Meteorological Data, Rain Fall, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Rain Fall data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  2. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Water Level

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have water surface height above a reference datum. *These services are for...

  3. NOS CO-OPS Meteorological Data, Wind, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Wind data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been subjected...

  4. NOS CO-OPS Meteorological Data, Air Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Air Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  5. NOS CO-OPS Meteorological Data, Visibility, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Visibility data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  6. NOS CO-OPS Meteorological Data, Conductivity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Conductivity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  7. NOS CO-OPS Meteorological Data, Water Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Water Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  8. NOS CO-OPS Meteorological Data, Barometric Pressure, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Barometric Pressure data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  9. NOS CO-OPS Water Level Data, Preliminary, 1-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has recent, preliminary (not quality-controlled), 1-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and...

  10. eNOS-uncoupling in age-related erectile dysfunction

    OpenAIRE

    Johnson, JM; Bivalacqua, TJ; Lagoda, GA; Burnett, AL; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH4) on erectile function in the aged rats. Male Fischer 344 ...

  11. Safety evaluation report related to the operation of Palo Verde Nuclear Generating Station, Units, 1, 2, and 3: Docket Nos. STN 50-528, STN 50-529, and STN 50-530

    International Nuclear Information System (INIS)

    1983-03-01

    Information is presented concerning site characteristics; mechanical systems and components; reactor coolant system; engineered safety systems; reactor instrumentation; reactor operations; and quality assurance

  12. Safety evaluation report related to the operation of LaSalle County Station, Units 1 and 2. Docket Nos. 50-373 and 50-374, Commonwealth Edison Company

    International Nuclear Information System (INIS)

    1982-04-01

    Information is presented concerning design criteria for structures, systems, and components; electric power systems; auxiliary systems; conduct of operations; accident analysis; and TMI-2 action plan requirements

  13. Technical evaluation report on the adequacy of station electric-distribution-system voltages for the Millstone Nuclear Power Station, Units 1 and 2. Docket Nos. 50-245, 50-336

    International Nuclear Information System (INIS)

    Selan, J.C.

    1983-01-01

    This report documents the technical evaluation of the adequacy of the station electric-distribution-system voltages for the Millstone Nuclear Power Station, Units 1 and 2. The evaluation is to determine if the onsite distribution system, in conjunction with the offsite power sources, has sufficient capacity to automatically start and operate all Class 1E loads within the equipment voltage ratings under certain conditions established by the Nuclear Regulatory Commission. The analyses submitted demonstrate that adequate voltages will be supplied to the Class 1E equipment under the worst-case conditions analyzed

  14. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446). Supplement No. 9

    International Nuclear Information System (INIS)

    1985-03-01

    This supplement addresses TUEC's analyses in support of its request to amend the Comanche Peak Final Safety Analysis Report to eliminate the commitment that coatings inside the reactor Containment Building be qualified for Units 1 and 2. In addition, this supplement provides the results of the staff's evaluation and resolution of 62 technical concerns and allegations in the coatings area for Unit 1. Because of the favorable resolution of the items discussed in this report, the staff concludes for the issues considered herein, that there is reasonable assurance that the facility can be operated by TUEC without endangering the health and safety of the public

  15. Operation of Grand Gulf Nuclear Station, Units 1 and 2, Dockets Nos. 50-416 and 50-417: Mississippi Power and Light Company, Middle South Energy, Inc., South Mississippi Electric Power Association. Final environmental statement

    International Nuclear Information System (INIS)

    1981-09-01

    The information in this Final Environmental Statement is the second assessment of the environmental impacts associated with the construction and operation of the Grand Gulf Nuclear Station, Units 1 and 2, located on the Mississippi River in Claiborne County, Mississippi. The Draft Environmental Statement was issued in May 1981. The first assessment was the Final Environmental Statement related to construction, which was issued in August 1973 prior to issuance of the Grand Gulf Nuclear Station construction permits. In September 1981 Grand Gulf Unit 1 was 92% complete and Unit 2 was 22% complete. Fuel loading for Unit 1 is scheduled for December 1981. The present assessment is the result of the NRC staff review of the activities associated with the proposed operation of the Station, and includes the staff responses to comments on the Draft Environmental Statement

  16. Final environmental statement related to construction of Cherokee Nuclear Station, Units 1, 2, and 3: (Docket Nos. STN 50-491, STN 50-492, and STN 50-493)

    International Nuclear Information System (INIS)

    1975-10-01

    The proposed action is the issuance of a construction permit to the Duke Power Company for the construction of the Cherokee Nuclear Station (CNS) Units 1, 2, and 3 located in Cherokee County, South Carolina. A total of 2263 acres will be removed from public use for the CNS site. Construction-related activities on the site will disturb about 751 acres. Approximately 654 acres of land will be required for transmission line right-of-way, and a railroad spur will affect 83 acres. This constitutes a minor regional impact. No significant environmental impacts are anticipated from normal operational releases of radioactive materials. The total annual dose to the US population (total body plus thyroid) from operation of the plant is 210 man-rems which is less than the normal fluctuations in the background dose this population would receive. The occupational dose is approximately 1400 man-rems/year. The heat dissipation system will require a maximum water makeup of 55,814 gpm, of which 50,514 gpm will be consumed due to drift and evaporative losses. This amount represents 4.5% of the mean monthly flow and 23.8% of the low flow of the Broad River. The cooling tower blowdown and chemical effluents from the station will increase the dissolved solids concentration in the river by a maximum of 44 ppM. The thermal alterations and increases in total dissolved solids concentration will not significantly affect the aquatic productivity of the river. 114 refs., 25 figs., 46 tabs

  17. Environmental assessment for renewal and consolidation of Materials License Nos. SNM-362, SMB-405, 08-00566-05, 08-00566-10, and 08-00566-12 (Docket No. 70-398)

    International Nuclear Information System (INIS)

    1985-03-01

    The proposed action for which this Environmental Assessment is prepared is the renewal and consolidation of five nuclear materials licenses for radiological activities at the National Bureau of Standards (NBS) site. These licenses cover most uses of radioactive material at NBS except that controlled by the license for operation of the NBS reactor. The reactor license is not associated with and will not be affected by the currently proposed licensing action

  18. Final supplement to the final environmental statement related to construction of Palo Verde Nuclear Generating Station Units 1, 2 and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530)

    International Nuclear Information System (INIS)

    1976-02-01

    The proposed action is the issuance of construction permits to the Arizona Public Service Company for the construction of the Palo Verde Nuclear Generating Station, Units 1, 2, and 3. Preparation of the 3800-acre site will involve the clearing of up to 2500 acres of land, 1500 of which will ultimately be developed during the lifetime of the station. About 2200 site acres, previously devoted to agriculture, will be excluded from this land use. Soil disturbance during construction of the station, transmission lines, and water conveyance pipeline will tend to promote erosion and increase siltation local ephemeral water courses. Stringent measures will be taken to minimize these effects (Sec. 4.5). Station, transmission line, and water pipeline construction will kill, remove, displace, or otherwise disturb involved flora and fauna, and will eliminate varying amounts of wildlife breeding, nesting, and forage habitat. These will not be important permanent impacts to the population stability and structure of the involved local ecosystems of the Sonoran desert; however, measures will be taken to minimize such effects as do results from the proposed action. 26 refs., 1 fig., 20 tabs

  19. Safety evaluation report related to the operation of LaSalle County Station, Units 1 and 2. Docket Nos. 50-373 and 50-374. Suppl. No. 5

    International Nuclear Information System (INIS)

    1983-08-01

    Revised information is presented concerning seismic qualification of components; fuel assembly stress analysis; in-service inspection of primary coolant circuits and engineered safety systems; instrumentation; electric equipment; auxiliary systems; operational security; and TMI-2 requirements

  20. Safety-evaluation report related to the operation of Diablo Canyon Nuclear Power Plant, Units 1 and 2 (Docket Nos. 50-275 and 50-323). Supplement No. 16

    International Nuclear Information System (INIS)

    1983-08-01

    This supplement addresses certain allegations received by the staff concerning safety deficiencies at the Diablo Canyon project, specifically those relative to design aspects of the component cooling water system (CCWS), including its seismic classification, single failure considerations, and its heat removal capabilities. It is based on the staff's re-review of the Diablo Canyon Final Safety Analysis Report (FSAR); on a site walkdown conducted on January 12, 1983; on information obtained during meetings with the applicant dated March 15, 18, and 25, April 4, 7, and 15, and May 3 and 18, 1983

  1. Safety evaluation report related to the operation of LaSalle County Station, Units 1 and 2, (Docket Nos. 50-373 and 50-374). Supplement No. 7

    International Nuclear Information System (INIS)

    1983-12-01

    Supplement No. 7 to the Safety Evaluation Report of Commonwealth Edison Company's application for a license to operate its La Salle County Station, Unit 2, located on Brookfield Township, La Salle County, Illinois, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement is to update our evaluations on Unit 2 issues identified in the previous Safety Evaluation Report and Supplements that need resolution prior to issuance of the operating license for Unit 2

  2. Safety evaluation report related to the operation of Susquehanna Steam Electric Station, Units 1 and 2. Docket Nos. 50-387 and 50-388, Pennsylvania Power and Light Company, Allegheny Electric Cooperative, Inc

    International Nuclear Information System (INIS)

    1982-07-01

    Information is presented concerning site characteristics; design criteria for systems and components; reactor thermal and hydraulic characteristics; reactor coolant pressure boundary; engineered safety features; instrumentation and control; electrical power systems; auxiliary systems; conduct of operations; quality assurance; and TMI-2 requirements

  3. Safety evaluation report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2. Dockets Nos. 50-416 and 50-417, Mississippi Power and Light Company; Middle South Energy, Inc., South Mississippi Electric Power Association

    International Nuclear Information System (INIS)

    1982-06-01

    Supplement 2 to the Safety Evaluation Report for Mississippi Power and Light Company, et. al, joint application for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2, located on the east bank of the Mississippi River near Port Gibson, in Claiborne County, Mississippi, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

  4. Draft environmental statement related to the operation of South Texas Project, Units 1 and 2 (Docket Nos. 50-498 and 50-499). Houston Lighting and Power Company

    International Nuclear Information System (INIS)

    1986-03-01

    This Draft Environmental Statement contains the second assessment of the environmental impact associated with the operation of the South Texas Project, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the ''Code of Federal Regulations,'' Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environmental impacts, environmental consequences and mitigating actions, and environmental and economic benefits and costs associated with station operation. Land use and terrestrial and aquatic ecological impacts will be small. No operational impacts to historic and archaeological sites are anticipated. The effects of routine operations, energy transmission, and periodic maintenance of rights-of-way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk of radiation exposure associated with accidental release of radioactivity is very low. Socioeconomic impacts of the project are anticipated to be minimal. The action called for is the issuance of an operating license for South Texas Project, Units 1 and 2

  5. Final supplement to the final environmental statement related to construction of Skagit Nuclear Power Project, Units 1 and 2: (Docket Nos. STN 50-522 and STN 50-523)

    International Nuclear Information System (INIS)

    1977-04-01

    The proposed action is the issuance of construction permits to the Puget Sound Power and Light Company, Pacific Power and Light Company, Washington Water Power Company and the Portland General Electric Company, for the construction of Skagit Nuclear Power Projects Units 1 and 2 in Skagit County, Washington (about 64 miles north of Seattle and 6 miles ENE of Sedro Woolley). These units are scheduled for commercial service in 1984 and 1986, respectively. The exhaust steam from the turbine-generators will be cooled in condensers which will utilize one hyperbolic-type natural-draft cooling tower per unit to dissipate heat to the atmosphere. Water (106 cfs max.) for the cooling tower makeup (82.4 cfs) and other plant uses will be withdrawn from the Skagit River through Ranney Collectors embedded in the north bank of the river and pumped to the plant through a pipeline about 35,000 ft. long. Cooling tower blowdown (7 cfs max.) from the project and dilution water (20 cfs max.) will flow through a pipeline back to the river where it will be discharged through a diffuser. Approximately 1750 acres of forested and agricultural land will be removed from harvesting for the life of the power plant; 360 acres of this land will be diverted to industrial use. This will affect less than 0.5% of standing forest in Skagit County and 16 acres in cultivated crops and pasturage. Increased siltation of onsite creeks and the Skagit River from construction work and the small amounts of heat and chemicals discharged to the river during plant operation will have insignificant impacts on water quality and aquatic biota due to erosion control efforts and dilution by the large river flow. (16,200 cfs average; 4740 cfs 7-day, 10-yr low). 18 figs

  6. Operation of South Texas Project, Units 1 and 2 Docket Nos. 50-498 and 50-499, Houston Lighting and Power Company et.al., Matagorda County, Texas

    International Nuclear Information System (INIS)

    1986-08-01

    The final environmental impact statement (EPA No. 860376F) on a proposal to issue operating licenses for units 1 and 2 of the South Texas Project describes the two pressurized waters reactors that will produce 1250 MWe per unit. A closed-cycle will use water from the Colorado River for cooling. The site will include prime farmland. The study finds no significant effect on aquatic productivity of the river and no disruptions of the terrestrial biota. Economic benefits will include about 1800 new jobs, which will raise tax revenues and spur the local economy. Area marsh lands and wildlife habitat will suffer. The risk of exposure to accidental radiation is considered very low. The Federal Water Pollution Control Act of 1972 and Nuclear Regulatory Commission Licensing require the impact study

  7. Safety evaluation report related to the operation of San Onofre Nuclear Generating Station, Units 2 and 3. Docket Nos. 50-361 and 50-362, Southern California Edison Company, et al

    International Nuclear Information System (INIS)

    1982-06-01

    Information is presented concerning seismic design of structures, components, and equipment; reactor coolant system; conduct of operations; initial test program; quality assurance; and Three Mile Island-2 requirements

  8. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446). Supplement No. 13

    International Nuclear Information System (INIS)

    1986-05-01

    Supplement 13 to the Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement presents the staff's evaluation of the Comanche Peak Response Team (CPRT) Program Plan which was formulated by the applicant to resolve various construction and design issues raised by the Atomic Safety and Licensing Board, allegers, intervenor Citizens Association for Sound Energy (CASE), NRC inspections of various types, and Cygna Energy Services while conducting its independent design assessment. The NRC staff concludes that the CPRT Program Plan provides an overall structure for addressing all existing issues and any future issues which may be identified from further evaluations, and if properly implemented will provide important evidence of the design and construction quality of CPSES, and will identify any needed corrective action. The report identifies items to be addressed by the NRC staff during the implementation phase

  9. Safety evaluation report related to the operation of Susquehanna Steam Electric Station, Units 1 and 2. Docket Nos. 50-387 and 50-388, Pennsylvania Power and Light Company and Allegheny Electric Cooperative, Inc

    International Nuclear Information System (INIS)

    1982-11-01

    In April 1981, the staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report (NUREG-0776) regarding the application of the Pennsylvania Power and Light Company (the licensee) and the Allegheny Electric Cooperative, Inc. (co-licensee) for licenses to operate the Susquehanna Steam Electric Station, Units 1 and 2, located on a site in Luzerne County, Pennsylvania. Supplement 1, issued in June 1981, addressed outstanding issues. Supplement 2, issued in September 1981, contains the ACRS Report and responses. Supplement 3, issued in July 1982, contains the resolution to five items previously identified as open and closes them out. On July 17, 1982, License NPF-14 was issued to allow Unit 1 operation at power levels not to exceed 5% of rated power. This supplement discusses the resolution of several license conditions that have been met

  10. Technical evaluation report TMI action: NUREG-0737 (II.D.1) relief and safety valve testing,. Diablo Canyon Units 1 and 2 (Docket Nos. 50-275, 50-323)

    International Nuclear Information System (INIS)

    Miller, G.K.; Magleby, H.L.; Nalezny, C.L.

    1984-07-01

    Light water reactor operators have experienced a number of occurrences of improper performance of safety and relief valves installed in their primary coolant systems. Because of this, the authors of NUREG-0578 (TMI-2 Lessons Learned Task Status Report and Short-Term Recommendations) and subsequently NUREG-0737 (Clarification of TMI Action Plan Requirements) recommended that programs be developed and completed which would reevaluate the functional performance capabilities of Pressurized Water Reactor (PWR) safety, relief, and block valves and which would verify the integrity of the piping systems for normal, transient and accident conditions. This report provides the results of the review of these programs and their results by the Nuclear Regulatory Commission (NRC) and their consultant, EG and G Idaho, Inc. Specifically, this report has examined the response of the Licensee for Diablo Canyon Units 1 and 2, to the requirements of NUREG-0578 and NUREG-0737 and finds that the Licensee has provided an acceptable response, reconfirming that the General Design Criteria 14, 15 and 30 of Appendix A to 10 CRF 50 have been met. 18 refs

  11. Final Environmental Statement related to the operation of Perry Nuclear Power Plant, Units 1 and 2 Docket Nos. 50-440 and 50-441, Cleveland Electric Illuminating Company

    International Nuclear Information System (INIS)

    1982-08-01

    The information in this Final Environmental Statement is the second assessment of the environmental impact associated with the construction and operation of the Perry Nuclear Power Plant, Units 1 and 2, located on Lake Erie in Lake County, about 11 km (7 mi) northeast of Painesville, Ohio. The first assessment was the Final Environmental Statement related to the construction of the plant issued in April 1974, prior to issuance of the construction permits (CPRR-148 and CPPR-149). Plant construction for Unit 1 is currently about 83% complete, and Unit 2 about 43% complete. Fuel loading for Units 1 and 2 currently estimated by the licensee (Cleveland Electric Illuminating Company) for November 1983, with Unit 2 fuel load scheduled for May 1987. The present assessment is the result of the NRC staff review of the activities associated with the proposed operation of the plant

  12. Palo Verde Nuclear Generating Station, Units 1, 2 and 3 (Docket Nos. STN 50-528, STN 50-529 and STN 50-530): Draft supplement to the Final environmental satement

    International Nuclear Information System (INIS)

    1975-11-01

    The proposed action is the issuance of construction permits to the Arizona Public Service Company for the construction of the Palo Verde Nuclear Generating Station, Units 1, 2, and 3. Preparation of the 3800-acre site will involve the clearing of up to 2500 acres of land, 1500 of which will be permanently devoted to station facilities. An additional 1200- to 1300-acre evaporation pond will ultimately be developed during the lifetime of the station. About 2200 site acres, previously devoted to agriculture, will be excluded from this land use. Soil disturbance during construction of the station, transmission lines, and water conveyance pipeline will tend to promote erosion and increase siltation in local ephemeral water courses. Stringent measures will be taken to minimize these effects. Station, transmission line, and water pipeline construction will kill, remove, displace, or otherwise disturb involved flora and fauna, and will eliminate varying amounts of wildlife breeding, nesting, and forage habitat. These will not be important permanent impacts to the population stability and structure of the involved local ecosystems of the Sonoran desert; however, measures will be taken to minimize such effects as do result from the proposed action. The pumping of groundwater will cause a local drawdown of about 1 ft/yr, less than that currently occurring; hence, the impact is considered acceptable. 1 fig., 20 tabs

  13. Draft Environmental Statement related to the operation of Seabrook Station, Units 1 and 2. Docket Nos. 50-443 and 50-444, Public Service Company of New Hampshire, et al

    International Nuclear Information System (INIS)

    1982-05-01

    This Draft Environmental Statement contains the second assessment of the environmental impact associated with the operation of the Seabrook Station, Units 1 and 2 pursuant to the National Environmental Policy Act of 1969 (NEPA) and 10 CFR 51, as amended, of the NRC regulations. This statement examines: the effected environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs. Land use and terrestrial and aquatic-ecological impacts will be small. Operational impacts to historic and archeological sites will be negligible. The effects of routine operations, energy transmission, and periodic maintenance of rights-of-way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk associated with accidental radiation exposure is very low. The net socioeconomic effects of the project will be beneficial. The action called for is the issuance of an operating license for Seabrook Station, Units 1 and 2

  14. Safety evaluation report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3: Docket Nos. STN 50-528, STN 50-529, and STN 50-530

    International Nuclear Information System (INIS)

    1982-09-01

    Additional information is presented concerning site characteristics; inservice testing of pumps and valves; reactor coolant system; engineered safety systems; electric power systems; auxiliary systems; and quality assurance

  15. Safety Evaluation Report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446). Supplement No. 10

    International Nuclear Information System (INIS)

    1985-04-01

    This Supplement provides the results of the staff's evaluation and resolution of approximately 400 technical concerns and allegations in the mechanical and piping area regarding construction practices at the Comanche Peak facility. This report does not address the Walsh/Doyle allegations regarding deficiencies in the pipe support design process and the new allegations recently received by the staff

  16. Proposed design modifications and technical specification changes on grid voltage degradation for the Point Beach Nuclear Plant, Units 1 and 2 (Docket Nos. 50-266 and 50-301). Technical evaluation report

    International Nuclear Information System (INIS)

    White, R.L.

    1981-01-01

    This report documents the technical evaluation of the proposed design mofifications and Technical Specification changes for protection of Class 1E equipment from grid voltage degradation for the Point Beach Nuclear Plant, Units 1 and 2. The review criteria are based on several IEEE standards and the Code of Federal Regulations. The evaluation compares the submittals made by the licensee with the NRC staff positions and the review criteria and presents the reviewer's conclusion on the acceptability of the proposed system

  17. Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530). Supplement No. 8

    International Nuclear Information System (INIS)

    1985-05-01

    Purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of additional information submitted by the applicant since Supplement No. 7 was issued and matters that the staff had under review when Supplement No. 7 was issued, specifically those issues which required resolution prior to plant operation of Unit 1 above 5% full power

  18. Final environmental statement related to the operation of Catawba Nuclear Station, Units 1 and 2. Docket Nos. 50-413 and 50-414, Duke Power Company, et al

    International Nuclear Information System (INIS)

    1983-01-01

    This Final Environmental Statement contains the second assessment of the environmental impact associated with the operation of the Catawba Nuclear Station, Units 1 and 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and 10 CFR 51, as amended, of the NRC regulations. This statement examines: the affected environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs. Land use and terrestrial and aquatic-ecological impacts will be small. Operational impacts to historic and archeological sites will be negligible. The effects of routine operations, energy transmission, and periodic maintenance of rights-of-way and transmission facilities should not jeopardize any populations of endangered or threatened species. No significant impacts are anticipated from normal operational releases of radioactivity. The risk associated with accidental radiation exposure is very low. The net socioeconomic effects of the project will be beneficial

  19. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446): Supplement No. 21

    International Nuclear Information System (INIS)

    1989-04-01

    Supplement 21 to the Safety Evaluation Report related to the operation of the Comanche Peak Steam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission (NRC). The facility is located in Somervell County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement reports the status of certain issues that had not been resolved when the Safety Evaluation Report and Supplements 1, 2, 3, 4, 6, and 12 to that report were published. This supplement also lists the new issues that have been identified since Supplement 12 was issued and includes the evaluations for licensing items resolved in this interim period. 21 refs

  20. Technical evaluation report on the adequacy of station electric distribution system voltages for the Point Beach Nuclear Plant, Units 1 and 2. (Docket Nos. 50-266, 50-301)

    International Nuclear Information System (INIS)

    White, R.L.

    1983-01-01

    This report documents the technical evaluation of the adequacy of the station electric distribution system voltages for the Point Beach Nuclear Plant, Units 1 and 2. The evaluation is to determine if the onsite distribution system, in conjunction with the offsite power sources, has sufficient capacity to automatically start and operate all Class 1E loads within the equipment voltage ratings under certain conditions established by the Nuclear Regulatory Commission. For the worst case conditions study submitted by the licensee, it was shown that the station electric distribution system voltages would be adequate to start and operate 4160-volt and 480-volt Class 1E loads and their associated low voltage controls

  1. Role of iNOS and eNOS expression in a group of Egyptian diabetic and nondiabetic nephropathy patients

    Directory of Open Access Journals (Sweden)

    Mayssa I. Aly

    2013-01-01

    Conclusion The presence of iNOS is associated with tubular damage resulting in renal failure. The upregulation of NO in diabetes mellitus type 2 may explain the endothelial dysfunction that is associated with almost all diabetic complications.

  2. 75 FR 42436 - Houston Pipe Line Company LP-Bammel Storage, Docket No. PR10-51-000, et. al.; Notice of Baseline...

    Science.gov (United States)

    2010-07-21

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Houston Pipe Line Company LP--Bammel Storage, Docket No. PR10-51- 000, et. al.; Notice of Baseline Filings July 14, 2010. Houston Pipe Line..., 2010, respectively the applicants listed above submitted their baseline filing of its Statement of...

  3. Melanoma NOS1 expression promotes dysfunctional IFN signaling.

    Science.gov (United States)

    Liu, Qiuzhen; Tomei, Sara; Ascierto, Maria Libera; De Giorgi, Valeria; Bedognetti, Davide; Dai, Cuilian; Uccellini, Lorenzo; Spivey, Tara; Pos, Zoltan; Thomas, Jaime; Reinboth, Jennifer; Murtas, Daniela; Zhang, Qianbing; Chouchane, Lotfi; Weiss, Geoffrey R; Slingluff, Craig L; Lee, Peter P; Rosenberg, Steven A; Alter, Harvey; Yao, Kaitai; Wang, Ena; Marincola, Francesco M

    2014-05-01

    In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. Comparison of gene transcription and array comparative genomic hybridization (aCGH) between melanoma cells from different patients indicated that suppression of IFN-α signaling correlates with an amplification of the NOS1 locus within segment 12q22-24. Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α. Furthermore, in an explorative study, NOS1 expression in melanoma metastases was negatively associated with patient response to adoptive T cell therapy. This study provides a link between cancer cell phenotype and IFN signal dysfunction in circulating immune cells.

  4. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    Science.gov (United States)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P goats.

  5. Envolvimento nos direitos humanos e sistemas de valores

    OpenAIRE

    Pereira,Cícero; Ribeiro,Ana Raquel Correia; Cardoso,Sandro José

    2004-01-01

    Com base no modelo da análise quantitativa das representações sociais, o estudo (N = 300) tratou do posicionamento de estudantes universitários em relação aos Direitos Humanos (DHs) e à ancoragem social desse posicionamento nos sistemas de valores dos estudantes. Os resultados mostram que as representações dos estudantes sobre o envolvimento nos DHs envolvem quatro princípios organizadores: pessoal-abstrato; pessoal-concreto; governamental-abstrato; governamental-concreto. Em relação à ancora...

  6. Los medios de comunicación ¿nos igualan o nos diferencian?

    Directory of Open Access Journals (Sweden)

    Javier BALLESTA PAGÁN

    2009-05-01

    Full Text Available RESUMEN: En este artículo presentamos los resultados obtenidos en una investigación llevada a cabo en los centros educativos de Educación Secundaria Obligatoria de la Región de Murcia donde se ha pretendido valorar el equipamiento, el acceso a la información y el consumo de medios de comunicación en el hogar, por parte del alumnado inmigrante en comparación con el autóctono. Los datos aportados de dicho estudio nos confirman que la mayoría de los recursos más utilizados en el hogar es menor en los hogares del alumnado inmigrante de Educación Secundaria Obligatoria (ESO respecto al resto de la muestra en general de los alumnos. Por otra parte, el acceso a los medios, para estos alumnos inmigrantes, corrobora que son considerados recursos de gran importancia como vehículos en su acercamiento al aprendizaje y al entretenimiento. En cuanto al uso personal de dichos medios de comunicación observamos que mientras el ordenador, el móvil y el DVD son muy utilizados, comprobamos cómo desciende su uso e interés cuando abordamos otros medios de papel impreso, entre los que destacamos el libro y el periódico. Sin embargo, el uso de la televisión es bastante similar en ambos colectivos. Con relación al acceso a Internet, los resultados analizados parecen confirmar que el hogar se convierte en el lugar adecuado para su uso en ambas muestras, por encima de otros espacios públicos o privados. Sin embargo, si comprobamos la disponibilidad de acceso al mismo en el hogar por parte del alumnado inmigrante, destacamos que es menor de la que disponen los hogares autóctonos. En relación con la lectura, el nivel lector de estos jóvenes inmigrantes es también menor, aunque no existe una gran diferencia, respecto de la muestra de alumnos autóctonos. Al valorar el uso que hacen de la biblioteca comprobamos que más de la mitad de los alumnos afirman ir a ella, pero preferentemente a la pública más que la biblioteca del centro o a la de otras

  7. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    Science.gov (United States)

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  8. Pubertal development of penile Nitric Oxide Synthase (NOS ...

    African Journals Online (AJOL)

    Conclusion: The number of NADPH-positive fibers increases with age; however similar tumescence was recorded following electrostimulation in all age groups. NOS-nerve growth correlates with serum testosterone level. The increase of NADPH-positive fibers was accompanied by a decrease in the delay of onset of penile ...

  9. Title list of documents made publicly available. Documents from October-December 1978 for Dockets 50-334 through STN 50-597

    International Nuclear Information System (INIS)

    1978-01-01

    This special edition of the Title List contains Docket 50 material from 1978 that has not appeared in previous issues of the Title List. The documents in this supplement are indexed by personal author, corporate source, and report number. The listings of this material on the domestic licensing of production and utilization facilities, divided into the categories used for filing and searching in the NRC Public Document Room, are presented

  10. Safety evaluation report related to the operation of Waterford Steam Electric Station, Unit No. 3 (Docket No. 50-382). Supplement No. 7

    International Nuclear Information System (INIS)

    1984-09-01

    Supplement 7 to the Safety Evaluation Report for Louisiana Power and Light's application for a license to operate Waterford Steam Electric Station, Unit 3 (Docket No. 50-382), located in St. Charles Parish, Louisiana, has been jointly prepared by the Office of Nuclear Reactor Regulation and the Region IV Office of the US Nuclear Regulatory Commission. This supplement provides the results to date of the staff's evaluation of approximately 350 allegations and concerns of poor construction practices at the Waterford 3 facility

  11. Safety evaluation report related to the operation of WPPSS Nuclear Project No. 2, Docket No. 50-397, Washington Public Power Supply System

    International Nuclear Information System (INIS)

    1982-12-01

    Supplement 2 to the Safety Evaluation Report for Washington Public Power Supply System's application for a license to operate WNP-2 (Docket No. 50-397), located in Benton County, Washington, approximately 12 miles north of Richland, Washington, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement 1

  12. Safety Evaluation Report related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412). Supplement No. 2

    International Nuclear Information System (INIS)

    1986-08-01

    This report, Supplement No. 2 to the the Safety Evaluation Report for the application filed by the Duquesne Light Company, et al. (the applicant) for a license to operate the Beaver Valley Power Station Unit 2 (Docket No. 50-412), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time the Safety Evaluation Report was published

  13. The influence of authentic scientific research experiences on teachers' conceptions of the nature of science (NOS) and their NOS teaching practices

    Science.gov (United States)

    Moriarty, Meghan A.

    This study explored the influence of teachers' authentic scientific research experiences (ASREs) on teachers' conceptions of the nature of science (NOS) and teachers' NOS instruction. Twelve high school biology teachers participated in this study. Six of the participants had authentic scientific research experience (ASRE) and six had not participated in authentic scientific research. Data included background surveys, modified Views of the Nature of Science (VNOS) questionnaires, interviews, and teaching observations. Data was coded based on the eight NOS understandings outlined in 2013 in the Next Generation Science Standards (NGSS). Evidence from this study indicates participating in authentic scientific research as a member of a scientific community has dual benefits of enabling high school science teachers with informed understandings of the NOS and positioning them to teach with the NOS. However, these benefits do not always result from an ASRE. If the nature of the ASRE is limited, then it may limit teachers' NOS understandings and their NOS teaching practices. The results of this study suggest that participation in ASREs may be one way to improve teachers' NOS understandings and teaching practices if the experiences themselves offer a comprehensive view of the NOS. Because ASREs and other science learning experiences do not always offer such experiences, pre-service teacher education and professional development opportunities may engage science teachers in two ways: (1) becoming part of a scientific community may enable them to teach with NOS and (2) being reflective about what being a scientist means may improve teachers' NOS understandings and better position them to teach about NOS.. Keywords: nature of science, authentic scientific research experiences, Next Generation Science Standards, teaching about NOS, teaching with NOS.

  14. Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

    Directory of Open Access Journals (Sweden)

    Mohamed A. Morsy

    2014-01-01

    Full Text Available Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p. for 6 days with and without sildenafil. Sildenafil administration resulted in nephroprotective effect in gentamicin-intoxicated rats as it significantly decreased serum creatinine and urea, urinary albumin, and renal malondialdehyde and nitrite/nitrate levels, with a concomitant increase in renal catalase and superoxide dismutase activities compared to gentamicin-treated rats. Moreover, immunohistochemical examination revealed that sildenafil treatment markedly reduced inducible nitric oxide synthase (iNOS expression, while expression of endothelial nitric oxide synthase (eNOS was markedly enhanced. The protective effects of sildenafil were verified histopathologically. In conclusion, sildenafil protects rats against gentamicin-induced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of iNOS expression, and induction of eNOS production.

  15. Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum.

    Science.gov (United States)

    Di Girolamo, G; Farina, M; Riberio, M L; Ogando, D; Aisemberg, J; de los Santos, A R; Martí, M L; Franchi, A M

    2003-07-01

    1. The therapeutic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is thought to be due mainly to its inhibition of cyclooxygenase (COX) enzymes, but there is a growing body of research that now demonstrates a variety of NSAIDs effects on cellular signal transduction pathways other than those involving prostaglandins. 2. Nitric oxide (NO) as a free radical and an agent that gives rise to highly toxic oxidants (peroxynitrile, nitric dioxide, nitron ion), becomes a cause of neuronal damage and death in some brain lesions such as Parkinson and Alzheimer disease, and Huntington's chorea. 3. In the present study, the in vivo effect of three NSAIDs (lysine clonixinate (LC), indomethacine (INDO) and meloxicam (MELO)) on NO production and nitric oxide synthase expression in rat cerebellar slices was analysed. Rats were treated with (a) saline, (b) lipopolysaccharide (LPS) (5 mg kg(-1), i.p.), (c) saline in combination with different doses of NSAIDs and (d) LPS in combination with different doses of NSAIDs and then killed 6 h after treatment. 4. NO synthesis, evaluated by Bred and Snyder technique, was increased by LPS. This augmentation was inhibited by coadministration of the three NSAIDs assayed. None of the NSAIDs tested was able to modify control NO synthesis. 5. Expression of iNOS and neural NOS (nNOS) was detected by Western blotting in control and LPS-treated rats. LC and INDO, but not MELO, were able to inhibit the expression of these enzymes. 6. Therefore, reduction of iNOS and nNOS levels in cerebellum may explain, in part, the anti-inflammatory effect of these NSAIDs and may also have importance in the prevention of NO-mediated neuronal injury.

  16. Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    April M Sapp

    Full Text Available Nitric oxide (NO is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and

  17. Participação nos Lucros ou Resultados

    Directory of Open Access Journals (Sweden)

    Luiz Felipe Ferreira

    2007-03-01

    Full Text Available A participação nos lucros ou resultados é uma forma de remuneração variável, pela qual não há incidência de encargos sociais, além de incentivar o aumento da produtividade, podendo assim ser utilizada pelas empresas como estratégia, para enfrentarem os desafios dinâmicos e competitivos em que atuam. Esta pesquisa caracteriza-se como sendo exploratória, com abordagem qualitativa e tem como objetivo conceituar e explanar as formas pela quais são praticadas a participação nos lucros ou resultados em empresas do setor alimentício em Santa Catarina, que foram escolhidas por meio do critério de acessibilidade e disponibilidade. Dos dados coletados, pode-se verificar que as empresas: COC Alimentos, Moinho Catarinense e Pepsico do Brasil utilizam a participação nos resultados e a Perdigão utiliza a participação mista. A Moinho Catarinense distribui para todos os empregados um salário nominal, como a CDC Alimentos, exceto para os gerentes. A Perdigão beneficia todos os empregados, sendo que 60% da distribuição é pelo lucro líquido e 40% por indicadores de desempenho. A Pepsico do Brasil distribui aos empregados operacionais 50% de um salário nominal e para os empregados da administração central um salário nominal, atrelado ao cumprimento de metas, especificadas no programa de participação nos lucros ou resultados.

  18. Tratamento de dejetos suínos com biorreator UASB

    Directory of Open Access Journals (Sweden)

    Pablo Costa da Silva

    2014-05-01

    Full Text Available Esse trabalho tem por objetivo analisar a importância do biodigestor UASB no tratamento de dejetos suínos. A suinocultura possui papel importante quanto ao desenvolvimento econômico do Brasil. No entanto, o aumento de produção vem causando problemas ambientais graves, por conta do grande volume de resíduos sólidos gerados pela atividade. O desenvolvimento de métodos de tratamento de dejetos que agreguem valor à produção e respeitem as leis ambientais é um dos grandes desafios do setor. A biodigestão anaeróbia é um dos métodos mais eficazes para o tratamento de dejetos de suinoculturas. Este método de digestão, denominado UASB, tem como característica principal a produção de biogás e de biofertilizante, produto rico em nutrientes, e livre de patógenos. O método oferece vantagens como a promoção do bem estar animal, o aumento da fertilidade do solo, a diminuição da poluição e da emissão de gases geradores do efeito estufa e a melhoria da qualidade de vida, nos centros produtores de suínos, além de minimizar problemas relacionados ao déficit de energia elétrica. Portanto, a utilização de biodigestores UASB para o tratamento de dejetos de suínos é uma opção interessante, que deve ser avaliada com seriedade.

  19. Pragmatismo e os pragmáticos nos estudos organizacionais

    Directory of Open Access Journals (Sweden)

    Francis Kanashiro Meneghetti

    Full Text Available O objetivo central deste ensaio teórico é avaliar as contribuições do pragmatismo nos Estudos Organizacionais e, os específicos, avaliar se as contribuições teóricas de Charles Peirce e John Dewey possibilitam afirmar o pragmatismo como senso comum, ciência ou teoria do conhecimento; analisar as contribuições - possibilidadese limites - do pragmatismo como conhecimento científico; compreender os percursos do pragmatismo nos Estudos Organizacionais. Chaga-se a conclusão de que ser pragmático é diferente de conceber estudos articulados no campo epistemológico do pragmatismo. O sujeito pragmático vê na sua utilidade e na necessidade deação, o ponto de tensão que coloca em dúvida a veracidade dos pressupostos do pragmatismo como ciência. O que ocorre nos Estudos Organizacionais éa conversão do pragmatismo como conhecimento científico emsubordinação irracional à utilidade e à ação prática, sobretudo, no campo da economia, da política, da ciência, da cultura, da educação, e assim por diante.

  20. Penser Système : Découvrir nos modèles d'organisation

    NARCIS (Netherlands)

    Bryan, B.; Goodman, M.; Schaveling, J.

    2011-01-01

    Pourquoi le travail s’accumule-t-il sur nos bureaux alors que nous travaillons de plus en plus? Parfois « nos solutions » aggravent nos problèmes. Comment pouvons-nous éviter ces paradoxes ? Penser système donne de nouvelles perspectives dans des situations complexes. Cela vous permettra de

  1. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    Science.gov (United States)

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies.

  2. Safety Evaluation Report related to the operation of Waterford Steam Electric Station, Unit No. 3 (Docket No. 50-382). Supplement No. 8

    International Nuclear Information System (INIS)

    1984-12-01

    Supplement 8 to the Safety Evaluation Report for the application filed by Louisiana Power and Light Company for a license to operate the Waterford Steam Electric Station, Unit 3 (Docket No. 50-382), located in St. Charles Parish, Louisiana, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing the staff's evaluation of information submitted by the applicant since the Safety Evaluation Report and its seven previous supplements were issued

  3. Safety-evaluation report related to the operation of Waterford Steam Electric Station, Unit No. 3. Docket No. 50-382

    International Nuclear Information System (INIS)

    1983-06-01

    Supplement 5 to the Safety Evaluation Report for the application filed by Louisiana Power and Light Company for a license to operate the Waterford Steam Electric Station, Unit 3 (Docket No. 50-382), located in St. Charles Parish, Louisiana has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing the staff's evaluation of information submitted by the applicant since the Safety Evaluation Report and its four previous Supplements were issued

  4. Safety evaluation report related to the operation of Waterford Steam Electric Station, Unit No. 3 (Docket No. 50-382). Suppl.6

    International Nuclear Information System (INIS)

    1984-06-01

    Supplement 6 to the Safety Evaluation Report for the application filed by Louisiana Power and Light Company for a license to operate the Waterford Steam Electric Station, Unit 3 (Docket No. 50-382), located in St. Charles Parish, Louisiana, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing the staff's evaluation of information submitted by the applicant since the Safety Evaluation Report and its five previous supplements were issued

  5. Safety Evaluation Report related to the operation of Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410)

    International Nuclear Information System (INIS)

    1985-02-01

    The Safety Evaluation Report for the application filed by the Niagara Mohawk Power Corporation, as applicant and co-owner, for a license to operate the Nine Mile Point Nuclear Station, Unit 2 (Docket No. 50-410), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near Oswego, New York. Subject to favorable resolution of the items discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  6. Safety Evaluation Report related to the operation of Waterford Steam Electric Station, Unit No. 3 (Docket No. 50-382). Supplement 9

    International Nuclear Information System (INIS)

    1984-12-01

    Supplement 9 to the Safety Evaluation Report for Louisiana Power and Light's application for a license to operate Waterford Steam Electric Station, Unit 3 (Docket No. 50-382), located in St. Charles Parish, Louisiana, has been jointly prepared by the Office of Nuclear Reactor Regulation and the Region IV Office of the US Nuclear Regulatory Commission. This supplement provides the results of the staff's completion of its evaluation of approximately 350 allegations and concerns of poor construction practices at the Waterford 3 facility

  7. Safety Evaluation Report related to the operation of Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410)

    International Nuclear Information System (INIS)

    1987-07-01

    This report supplements the Safety Evaluation Report (NUREG-1047, February 1985) for the application filed by Niagara Mohawk Power Corporation, as applicant and co-owner, for the license to operate Nine Mile Point Nuclear Station, Unit 2 (Docket No. 50-410). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near Oswego, New York. This report supports the issuance of the full-power license for Nine Mile Point Nuclear Station, Unit No. 2

  8. Safety evaluation report related to the operation of Shearon Harris Nuclear Power Plant, Unit No. 1 (Docket No. STN 50-400). Supplement No. 1

    International Nuclear Information System (INIS)

    1984-06-01

    This report, Supplement No. 1 to the Safety Evaluation Report for the application filed by the Carolina Power and Light Company and North Carolina Eastern Municipal Power Agency (the applicant) for license to operate the Shearon Harris Nuclear Power Plant Unit 1 (Docket No. 50-400), has been prepared by the Office of Nuclear Reactor Regulation of the U.S. Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

  9. Safety Evaluation Report related to the operation of Shearon Harris Nuclear Power Plant, Unit No. 1 (Docket No. STN 50-400). Supplement No. 2

    International Nuclear Information System (INIS)

    1985-06-01

    This report, Supplement No. 2 to the Safety Evaluation Report for the application filed by the Carolina Power and Light Company and North Carolina Eastern Municipal Power Agency (the applicants) for a license to operate the Shearon Harris Nuclear Power Plant Unit 1 (Docket No. 50-400), has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement No. 1

  10. Safety Evaluation Report related to the operation of Wolf Creek Generating Station, Unit No. 1 (Docket No. STN 50-482). Supplement No. 6

    International Nuclear Information System (INIS)

    1985-06-01

    This report supplements the Safety Evaluation Report (SER) for the application filed by the Kansas Gas and Electric Company, as applicant and agent for the owners, for a license to operate the Wolf Creek Generating Station, Unit 1 (Docket No. STN 50-482). The facility is located in Coffey County, Kansas. This supplement provides recent information regarding resolution of the license conditions identified in the SER. Because of the favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the licensee at power levels greater than 5% without endangering the health and safety of the public

  11. Safety Evaluation Report related to the operation of Millstone Nuclear Power Station Unit No. 3 (Docket No. 50-4423). Supplement No. 1

    International Nuclear Information System (INIS)

    1985-03-01

    In July 1984 staff of the Nuclear Regulatory Commission issued its Safety Evaluation Report regarding the application of Northeast Nuclear Energy Company (applicant and agent for the owners) for a license to operate Millstone Nuclear Power Station, Unit No. 3 (Docket 50-423). The facility is located in the town of Waterford, New London County, Connecticut, on the north shore of Long Island Sound. This first supplement to NUREG-1031 reports the status of certain items that remained unresolved at the time the Safety Evaluation Report was published

  12. Expression of Beta-catenin, COX-2 and iNOS in Colorectal Cancer: Relevance of COX-2 and iNOS Inhibitors for Treatment in Malaysia

    Directory of Open Access Journals (Sweden)

    Seok Kwan Hong

    2004-01-01

    Conclusions: The accumulation of β-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  13. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions about Using History of Science to Teach NOS

    Science.gov (United States)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-01-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing…

  14. Beer elicits vasculoprotective effects through Akt/eNOS activation.

    Science.gov (United States)

    Vilahur, Gemma; Casani, Laura; Mendieta, Guiomar; Lamuela-Raventos, Rosa M; Estruch, Ramon; Badimon, Lina

    2014-12-01

    There is controversy regarding the effect of alcohol beverage intake in vascular vasodilatory function in peripheral arteries. The effects of beer intake in coronary vasodilation remain unknown. We investigated whether regular beer intake (alcohol and alcohol-free) protects against hypercholesterolaemia-induced coronary endothelial dysfunction and the mechanisms behind this effect. Pigs were fed 10 days: (i) a Western-type hypercholesterolaemic diet (WD); (ii) WD+low-dose beer (12·5 g alcohol/day); (iii) WD+moderate-dose beer (25 g alcohol/day); or (iv) WD+moderate-dose alcohol-free-beer (0·0 g alcohol/day). Coronary responses to endothelium-dependent vasoactive drugs (acetylcholine: receptor mediated; calcium ionophore-A23189: nonreceptor mediated), endothelium-independent vasoactive drug (SNP) and L-NMMA (NOS-antagonist) were evaluated in the LAD coronary artery by flow Doppler. Coronary Akt/eNOS activation, MCP-1 expression, oxidative DNA damage and superoxide production were assessed. Lipid profile, lipoproteins resistance to oxidation and urinary isoxanthohumol concentration were evaluated. Alcoholic and nonalcoholic beer intake prevented WD-induced impairment of receptor- and non-receptor-operated endothelial-dependent coronary vasodilation. All animals displayed a similar vasodilatory response to SNP and L-NMMA blunted all endothelial-dependent vasorelaxation responses. Haemodynamic parameters remained unchanged. Coronary arteries showed lower DNA damage and increased Akt/eNOS axis activation in beer-fed animals. Animals taking beer showed HDL with higher antioxidant capacity, higher LDL resistance to oxidation and increased isoxanthohumol levels. Weight, lipids levels, liver enzymes and MCP-1 expression were not affected by beer intake. Non-alcoholic-related beer components protect against hyperlipemia-induced coronary endothelial dysfunction by counteracting vascular oxidative damage and preserving the Akt/eNOS pathway. Light-to-moderate beer

  15. A Fast Response Capability within NOAA/NOS/CO-OPS

    Science.gov (United States)

    2007-01-01

    A Fast Response Capability within NOAA/NOS/CO-OPS P. B. Burke NOAA/National Ocean Service/CO-OPS 1305 East-West Hwy. Silver Spring, MD 20910...USA pat.burke@noaa.gov T. Graff NOAA/National Ocean Service/CO-OPS 1305 East-West Hwy. Silver Spring, MD 20910 USA tammy.graff@noaa.gov... flotation hull, an instrumentation tower mounted atop the hull and a current meter mount with a mooring attachment. The triangular tower housed two

  16. O trabalho de vigilância nos centros comerciais

    OpenAIRE

    Gadea,Charles; Cruz,Sofia Alexandra

    2013-01-01

    Este artigo visa escrutinar em termos sociológicos a atividade profissional dos vigilantes nos centros comerciais, analisando o tipo de competências profissionais exigidas, a configuração da hierarquia profissional da vigilância e sua articulação com a comunicação cotidiana entre os vigilantes e, por fim, os desafios e dilemas subjacentes ao ato de vigiar. A pesquisa baseia-se metodologicamente em dados obtidos a partir de entrevistas semidiretivas a vigilantes e observação direta dos seus es...

  17. Medo de que? : uma historia do horror nos filmes brasileiros

    OpenAIRE

    Laura Loguercio Canepa

    2008-01-01

    Resumo: Neste trabalho, examinam-se as manifestações do gênero horror nos longas-metragens sonoros brasileiros realizados entre 1937 e 2007, elaborando-se um panorama histórico desses filmes, desde os primeiros registros cinematográficos deste gênero de ficção no cinema nacional até os mais recentes, e propondo-se um modelo descritivo para as configurações do horror ficcional no cinema brasileiro. Para isso, partiu-se dos estudos de gêneros cinematográficos, de história do cinema mundial e de...

  18. Non-ergodicity of Nosé–Hoover dynamics

    International Nuclear Information System (INIS)

    Legoll, Frédéric; Luskin, Mitchell; Moeckel, Richard

    2009-01-01

    The Nosé–Hoover dynamics is a deterministic method that is commonly used to sample the canonical Gibbs measure. This dynamics extends the physical Hamiltonian dynamics by the addition of a 'thermostat' variable, which is coupled nonlinearly with the physical variables. The accuracy of the method depends on the dynamics being ergodic. Numerical experiments have been published earlier that are consistent with non-ergodicity of the dynamics for some model problems. The authors recently proved the non-ergodicity of the Nosé–Hoover dynamics for the one-dimensional harmonic oscillator. In this paper, this result is extended to non-harmonic one-dimensional systems. We also show that, for some multidimensional systems, the averaged dynamics for the limit of infinite thermostat 'mass' has many invariants, thus giving theoretical support for either non-ergodicity or slow ergodization. Numerical experiments for a two-dimensional central force problem and the one-dimensional pendulum problem give evidence for non-ergodicity

  19. Ergodicity of the Stochastic Nosé-Hoover Heat Bath

    Science.gov (United States)

    Wei Chung Lo,; Baowen Li,

    2010-07-01

    We numerically study the ergodicity of the stochastic Nosé-Hoover heat bath whose formalism is based on the Markovian approximation for the Nosé-Hoover equation [J. Phys. Soc. Jpn. 77 (2008) 103001]. The approximation leads to a Langevin-like equation driven by a fluctuating dissipative force and multiplicative Gaussian white noise. The steady state solution of the associated Fokker-Planck equation is the canonical distribution. We investigate the dynamics of this method for the case of (i) free particle, (ii) nonlinear oscillators and (iii) lattice chains. We derive the Fokker-Planck equation for the free particle and present approximate analytical solution for the stationary distribution in the context of the Markovian approximation. Numerical simulation results for nonlinear oscillators show that this method results in a Gaussian distribution for the particles velocity. We also employ the method as heat baths to study nonequilibrium heat flow in one-dimensional Fermi-Pasta-Ulam (FPU-β) and Frenkel-Kontorova (FK) lattices. The establishment of well-defined temperature profiles are observed only when the lattice size is large. Our results provide numerical justification for such Markovian approximation for classical single- and many-body systems.

  20. A sociologia funcionalista nos estudos organizacionais: foco em Durkheim

    Directory of Open Access Journals (Sweden)

    Augusto Cabral

    Full Text Available O tema que estrutura este ensaio é o da sociologia funcionalista, particularmente em termos de sua influência nos estudos organizacionais. O seu foco de análise é duplo. Em um primeiro momento, as obras de Durkheim. Em um segundo momento, o impacto e a supremacia dos enfoques funcionalistas nos estudos organizacionais. Embora seus segmentos estejam inter-relacionados, ele é composto de quatro partes. Na primeira, é feita uma análise histórica da emergência e sistematização das ciências sociais, de modo a traçar sua evolução até o surgimento dos trabalhos de Durkheim. Na segunda, tomando como referencial a obra de Burrell e Morgan (1979, é estudado o paradigma funcionalista em termos de sua origem e expoentes, com destaque para Comte e Spencer, visando chegar a uma compreensão inicial do pensamento de Durkheim e de sua sociologia. Na terceira, a vida e as principais obras de Durkheim são sumariadas e discutidas. Por fim, o status atual dos estudos organizacionais -vistos como um conjunto impreciso, elástico e eclético de teorias e pesquisas sociais voltados para os problemas das organizações -é analisado em termos de seus pressupostos epistemológicos e ontológicos subjacentes, como meio de explicitar a supremacia dos enfoques positivistas-funcionalistas.

  1. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

    Directory of Open Access Journals (Sweden)

    Miriam M. Cortese-Krott

    2014-01-01

    Full Text Available Aberrant production of nitric oxide (NO by inducible NO synthase (iNOS has been implicated in the pathogenesis of endothelial dysfunction and vascular disease. Mechanisms responsible for the fine-tuning of iNOS activity in inflammation are still not fully understood. Zinc is an important structural element of NOS enzymes and is known to inhibit its catalytical activity. In this study we aimed to investigate the effects of zinc on iNOS activity and expression in endothelial cells. We found that zinc down-regulated the expression of iNOS (mRNA+protein and decreased cytokine-mediated activation of the iNOS promoter. Zinc-mediated regulation of iNOS expression was due to inhibition of NF-κB transactivation activity, as determined by a decrease in both NF-κB-driven luciferase reporter activity and expression of NF-κB target genes, including cyclooxygenase 2 and IL-1β. However, zinc did not affect NF-κB translocation into the nucleus, as assessed by Western blot analysis of nuclear and cytoplasmic fractions. Taken together our results demonstrate that zinc limits iNOS-derived high output NO production in endothelial cells by inhibiting NF-κB-dependent iNOS expression, pointing to a role of zinc as a regulator of iNOS activity in inflammation.

  2. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants.

    Science.gov (United States)

    Cassini-Vieira, Puebla; Araújo, Fernanda Assis; da Costa Dias, Filipi Leles; Russo, Remo Castro; Andrade, Silvia Passos; Teixeira, Mauro Martins; Barcelos, Luciola Silva

    2015-01-01

    There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined. The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated. Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS(-/-)) and wild-type (WT) mice. The hemoglobin content and number of vessels were decreased in the implants of iNOS(-/-) mice compared to WT mice 14 days after implantation. VEGF levels were also reduced in the implants of iNOS(-/-) mice. In contrast, the iNOS(-/-) implants exhibited an increased neutrophil and macrophage infiltration. However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively. Furthermore, the implants of iNOS(-/-) mice showed boosted collagen deposition. These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice.

  3. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

    Science.gov (United States)

    Cortese-Krott, Miriam M.; Kulakov, Larissa; Opländer, Christian; Kolb-Bachofen, Victoria; Kröncke, Klaus-D.; Suschek, Christoph V.

    2014-01-01

    Aberrant production of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathogenesis of endothelial dysfunction and vascular disease. Mechanisms responsible for the fine-tuning of iNOS activity in inflammation are still not fully understood. Zinc is an important structural element of NOS enzymes and is known to inhibit its catalytical activity. In this study we aimed to investigate the effects of zinc on iNOS activity and expression in endothelial cells. We found that zinc down-regulated the expression of iNOS (mRNA+protein) and decreased cytokine-mediated activation of the iNOS promoter. Zinc-mediated regulation of iNOS expression was due to inhibition of NF-κB transactivation activity, as determined by a decrease in both NF-κB-driven luciferase reporter activity and expression of NF-κB target genes, including cyclooxygenase 2 and IL-1β. However, zinc did not affect NF-κB translocation into the nucleus, as assessed by Western blot analysis of nuclear and cytoplasmic fractions. Taken together our results demonstrate that zinc limits iNOS-derived high output NO production in endothelial cells by inhibiting NF-κB-dependent iNOS expression, pointing to a role of zinc as a regulator of iNOS activity in inflammation. PMID:25180171

  4. Changes of serum NO/iNOS after whole abdominal irradiation in rats

    International Nuclear Information System (INIS)

    Lin Hong; Wu Wei; Zhang Kunhe; Chen Jiang; Wang Yang; Luo Hui; Huang Xiaoqing

    2004-01-01

    Objective: To observe the changes of serum NO/NOS concentrations in rats after whole abdominal irradiation and their relationships with intestinal radiation injury. Methods: Thirty health rats were randomly divided into three groups: normal control group, irradiation control group, and IgY protection group. The sera of rats were collected and the NO and iNOS were assayed. Results: NO and iNOS levels increased evidently in the irradiation control group in contrast with those of the normal control group (P<0.01). NO and iNOS levels increased slightly in the IgY protection group in contrast with the irradiation control group (P<0.01) and were close to the levels of the normal control group. The changes of NO and NOS concentrations were synchronous. Conclusion: NO and iNOS are good indices for detecting intestinal radiation injury. (authors)

  5. Circulating Blood eNOS Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis

    Science.gov (United States)

    Wood, Katherine C.; Cortese-Krott, Miriam M.; Kovacic, Jason C.; Noguchi, Audrey; Liu, Virginia B.; Wang, Xunde; Raghavachari, Nalini; Boehm, Manfred; Kato, Gregory J.; Kelm, Malte; Gladwin, Mark T.

    2013-01-01

    Objective Mice genetically deficient in endothelial nitric oxide synthase (eNOS−/−) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. While the current paradigm holds that this bioactivity derives specifically from expression of eNOS in endothelium, circulating blood cells also express eNOS protein. A functional red cell eNOS that modulates vascular NO• signaling has been proposed. Approach and Results To test the hypothesis that blood cells contribute to mammalian blood pressure regulation via eNOS-dependent NO• generation, we cross-transplanted WT and eNOS−/− mice, producing chimeras competent or deficient for eNOS expression in circulating blood cells. Surprisingly, we observed a significant contribution of both endothelial and circulating blood cell eNOS to blood pressure and systemic nitrite levels, the latter being a major component of the circulating NO• reservoir. These effects were abolished by the NOS inhibitor L-NAME and repristinated by the NOS substrate L-Arginine, and were independent of platelet or leukocyte depletion. Mouse erythrocytes were also found to carry an eNOS protein and convert 14C-Arginine into 14C-Citrulline in a NOS-dependent fashion. Conclusions These are the first studies to definitively establish a role for a blood borne eNOS, using cross transplant chimera models, that contributes to the regulation of blood pressure and nitrite homeostasis. This work provides evidence suggesting that erythrocyte eNOS may mediate this effect. PMID:23702660

  6. Safety evaluation report related to the operation of Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410)

    International Nuclear Information System (INIS)

    1986-07-01

    This report supplements the Safety Evaluation Report (NUREG-1047, February 1985) for the application filed by Niagara Mohawk Power Corporation, as applicant and co-owner, for a license to operate the Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near Oswego, New York. Supplement 1 to the Safety Evaluation Report was published in June 1985 and contained the report from the Advisory Committee on Reactor Safeguards as well as the resolution to a number of outstanding issues from the Safety Evaluation Report. Supplement 2 was published in November 1985 and contained the resolution to a number of outstanding and confirmatory issues. Subject to favorable resolution of the issues discussed in this report, the NRC staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  7. Safety Evaluation Report related to the operation of Millstone Nuclear Power Station, Unit No. 3 (Docket No. 50-423). Supplement No. 3

    International Nuclear Information System (INIS)

    1985-11-01

    This report supplements the Safety Evaluation Report (NUREG-1031) issued in July 1984, Supplement 1 issued in March 1985, and Supplement 2 issued in September 1985 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Northeast Nuclear Energy Company (applicant and agent for the owners) for a license to operate Millstone Nuclear Power Station, Unit No. 3 (Docket 50-423). The facility is located in the Town of Waterford, New London County, Connecticut, on the north shore of Long Island Sound. This supplement provides more recent information regarding resolution or updating of some of the open and confirmatory items and license conditions identified in the Safety Evaluation Report

  8. Safety Evaluation Report related to the operation of Wolf Creek Generating Station, Unit No. 1 (Docket No. STN 50-482). Supplement No. 5

    International Nuclear Information System (INIS)

    1985-03-01

    This report supplements the Safety Evaluation Report (SER) for the application filed by the Kansas Gas and Electric Company, as applicant and agent for the owners, for a license to operate the Wolf Creek Generating Station, Unit 1 (Docket No. STN 50-482). The facility is located in Coffey County, Kansas. This supplement has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission and provides recent information regarding resolution of the open items identified in the SER. Because of the favorable resolution of the items discussed in this report, the staff concludes that the facility can be operated by the applicant without endangering the health and safety of the public

  9. Safety Evaluation Report related to the operation of Millstone Nuclear Power Station, Unit No. 3 (Docket No. 50-423). Supplement No. 4

    International Nuclear Information System (INIS)

    1985-11-01

    This report supplements the Safety Evaluation Report (NUREG-1031) issued in July 1984, Supplement 1 issued in March 1985, Supplement 2 issued in September 1985, and Supplement 3 issued in November 1985, by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Northeast Nuclear Energy Company (applicant and agent for the owners) for a license to operate Millstone Nuclear Power Station, Unit No. 3 (Docket 50-423). The facility is located in the Town of Waterford, New London County, Connecticut, on the north shore of Long Island Sound. This supplement provides more recent information supporting the license for initial criticality and power ascension to 5% power operation for Millstone 3. 37 refs., 10 tabs

  10. Safety evaluation report related to the operation of Millstone Nuclear Power Station, Unit No. 3 (Docket No. 50-423). Supplement No. 5

    International Nuclear Information System (INIS)

    1986-01-01

    This report supplements the Safety Evaluation Report (NUREG-1031) issued in July 1984, Supplement 1 issued in March 1985, Supplement 2 issued in September 1985, Supplement 3 issued in November 1985, and Supplement 4 issued in November 1985 by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by Northeast Nuclear Energy Company (licensee and agent for the owners) for a license to operate Millstone Nuclear Power Station, Unit No. 3 (Docket 50-423). The supplement provides more recent information regarding resolution of license conditions identified in the SER. Because of the favorable resolution of the items discussed in this report, the staff concludes that Millstone Nuclear Power Station, Unit No. 3, can be operated by the licensee at power levels greater than 5% without endangering the health and safety of the public. 13 refs

  11. Crime e castigo nos Estados Unidos: de Nixon a Clinton

    Directory of Open Access Journals (Sweden)

    Loïc Wacquant

    1999-11-01

    Full Text Available Este artigo analisa o crescimento exponencial do número de detentos ocorrido nos Estados Unidos a partir de meados dos anos 70. Procura mostrar que esse crescimento não corresponde a um aumento da criminalidade, mas à conjugação de três séries causais, quais sejam: o declínio do "ideal de reabilitação" dos prisioneiros, a instrumentalização do medo da violência pelos políticos e pela mídia e a função de mecanismo de controle racial assumido pelo sistema penal americano. Em suma, a hiperflação carcerária revela a contraface do enfraquecimento do Estado de Bem-Estar Social e a sua substituição por um Estado penal.

  12. A metodologia nos processos midiáticos

    OpenAIRE

    GOMES S. J, PEDRO GILBERTO

    2011-01-01

    Um grande desafio que temos hoje é a definiç ão e o estabelecimento do objeto da comunicaç ão. Este texto pretende discutir tanto a questão do objeto quando da metodologia nos processos mediáticos. Dizemos que o objeto precede ao método. Não podemos escolher um método se não se coñ éese o objeto. Para isso realiza um pequeno recorrido sobre o problema do método nas ciencias sociais e sua relaç ão com o objeto. A importância dessa discussão no âmbito da comunicaç ão está relacionada com o prob...

  13. Safety evaluation report related to the operation of WPPSS Nuclear Project No. 2, (Docket No. 50-397). Supplement No. 4

    International Nuclear Information System (INIS)

    1983-12-01

    Supplement No. 4 to the Safety Evaluation Report on the application filed by Washington Public Power Supply System for a license to operate the WPPSS Nuclear Project No. 2, located in Richland, Washington, has been prepared by the Division of Licensing, Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report and Supplement Nos. 1, 2 and 3

  14. Crataegus Special Extract WS 1442 Effects on eNOS and microRNA 155.

    Science.gov (United States)

    Wang, Xinwen; Liang, Yan; Shi, Jian; Zhu, Hao-Jie; Bleske, Barry E

    2018-04-16

    Increased expression of microRNA 155 (miR-155) results in a decrease in endothelial nitric oxide synthase (eNOS) expression and impaired endothelial function. Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers ( Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids. The purpose of this study is to determine the effect of WS 1442 on the expression of miR-155 and eNOS in the presence of tumor necrosis factor (TNF- α ). Human umbilical vein endothelial cells (HUVECs) were studied after the exposure to TNF- α , with or without simvastatin (positive control) and WS 1442. The expression levels of eNOS, phosphorylated eNOS, and miR-155 in the different HUVEC treatment groups were determined by western blot and quantitative real-time polymerase chain reaction, respectively. To evaluate the effect of WS 1442 on the eNOS activity, the medium and intracellular nitrate/nitrite (NO) concentrations were also analyzed using a colorimetric Griess assay kit. The results demonstrated that TNF- α upregulated miR-155 expression and decreased eNOS expression and NO concentrations. WS 1442 also increased miR-155 expression and decreased eNOS expression but, unlike TNF- α , increased phosphorylated eNOS expression and NO concentrations. Surprisingly, WS 1442 increased miR-155 expression; however, WS 1442 mitigated the overall negative effect of miR-155 on decreasing eNOS expression by increasing expression of phosphorylated eNOS and resulting in an increase in NO concentrations. In the setting where miR-155 may be expressed, WS 1442 may offer vascular protection by increasing the expression of phosphorylated eNOS. Georg Thieme Verlag KG Stuttgart · New York.

  15. Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia.

    Science.gov (United States)

    Hong, Seok Kwan; Gul, Yunus A; Ithnin, Hairuszah; Talib, Arni; Seow, Heng Fong

    2004-01-01

    Promising new pharmacological agents and gene therapy targeting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) could modulate treatment of colorectal cancer in the future. The aim of this study was to elucidate the expression fo beta-catenin and teh presence of COX-2 and iNOS in colorectal cancer specimens in Malaysia. This is a useful prelude to future studies investigating interventions directed towards COX-2 adn iNOS. A cross-section study using retrospective data over a 2-year period (1999-2000) involved 101 archival, formalin-fixed, paraffin-embedded tissue samples of colorectal cancers that were surgically resected in a tertiary referral. COX-2 production was detected in adjacent normal tissue in 34 sample (33.7%) and in tumour tissue in 60 samples (59.4%). More tumours expressed iNOS (82/101, 81.2%) than COX-2. No iNOS expression was detected in adjacent normal tissue. Intense beta-catenin immunoreactivity at the cell-to-cell border. Poorly differentiated tumours had significantly lower total beta-catenin (p = 0.009) and COX-2 scores (p = 0.031). No significant relationships were established between pathological stage and beta-catenin, COX-2 and iNOS scores. the accumulation of beta-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  16. Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats

    Directory of Open Access Journals (Sweden)

    Poungrat Pakdeechote

    2014-01-01

    Full Text Available Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS induced by a high-carbohydrate, high-fat (HCHF diet. Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were treated with asiatic acid (10 or 20 mg/kg/day or vehicle for a further three weeks. MS rats had an impairment of oral glucose tolerance, increases in fasting blood glucose, serum insulin, total cholesterol, triglycerides, mean arterial blood pressure, heart rate, and hindlimb vascular resistance; these were related to the augmentation of vascular superoxide anion production, plasma malondialdehyde and tumor necrosis factor-alpha (TNF-α levels (p < 0.05. Plasma nitrate and nitrite (NOx were markedly high with upregulation of inducible nitric oxide synthase (iNOS expression, but dowregulation of endothelial nitric oxide synthase (eNOS expression (p < 0.05. Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-α, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p < 0.05. In conclusion, asiatic acid improved metabolic, hemodynamic abnormalities in MS rats that could be associated with its antioxidant, anti-inflammatory effects and recovering regulation of eNOS/iNOS expression.

  17. Expression profiles of eNOS, iNOS and microRNA-27b in the corpus cavernosum of rats submitted to chronic alcoholism and Diabetes mellitus.

    Science.gov (United States)

    Cunha, Joao Paulo da; Lizarte, Fermino Sanches; Novais, Paulo Cezar; Gattas, Daniela; Carvalho, Camila Albuquerque Mello de; Tirapelli, Daniela Pretti da Cunha; Molina, Carlos Augusto Fernandes; Tirapelli, Luis Fernando; Tucci, Silvio

    2017-01-01

    To evaluate the expression of endothelial and inducible NOS in addition to the miRNA-27b in the corpus cavernosum and peripheral blood of healthy rats, diabetic rats, alcoholic rats and rats with both pathologies. Forty eight Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D) and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study protein expressions of eNOS and iNOS by immunohistochemistry and expression of miRNA-27b in the corpus cavernosum and peripheral blood. Immunohistochemistry for eNOS and iNOS showed an increase in cavernosal smooth muscle cells in the alcoholic, diabetic and alcoholic-diabetic groups when compared with the control group. Similarly, the mRNA levels for eNOS were increased in cavernosal smooth muscle (CSM) in the alcoholic, diabetic and alcoholic-diabetic groups and miRNA-27b were decreased in CSM in the alcoholic, diabetic and alcoholic-diabetic groups. The major new finding of our study was an impairment of relaxation of cavernosal smooth muscle in alcoholic, diabetic, and alcoholic-diabetic rats that involved a decrease in the nitric oxide pathway by endothelium-dependent mechanisms accompanied by a change in the corpus cavernosum contractile sensitivity.

  18. NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study

    DEFF Research Database (Denmark)

    Grøntved, Anders; Andersen, Lars Bo; Franks, Paul W

    2011-01-01

    BackgroundIn this study, we examined the influence of genetic variation in NOS3 on resting blood pressure (BP) in children and adolescents from the European Youth Heart Study (EYHS). Because the NOS3 gene expression is altered by physical activity (PA), we also tested for interaction between...

  19. Suggesting a NOS Map for Nature of Science for Science Education Instruction

    Science.gov (United States)

    Oh, Jun-Young

    2017-01-01

    The aims of this research are 1) to explore the inter-relationships within the individual elements or tenets of Nature of Science (NOS), based on the dimensions of scientific knowledge in science learning, and 2) to consider Kuhn's concept of how scientific revolution takes place. This study suggests that instruction according to our NOS Flowchart…

  20. Association between nucleotide mutation of eNOS gene and serum ...

    African Journals Online (AJOL)

    Various mutation on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, the expansion factor (VEF) and may accelerate the process of atherosclerosis. The study was designed to investigate the frequency of T-786C polymorphism of the gene or nucleotide mutation of eNOS gene in patients ...

  1. Complex posttraumatic stress disorder: an exploratory investigation of PTSD and DES NOS among Dutch war veterans

    NARCIS (Netherlands)

    Jongedijk, R. A.; Carlier, I. V.; Schreuder, B. J.; Gersons, B. P.

    1996-01-01

    The recently developed concept Disorder of Extreme Stress Not Otherwise Specified (DES NOS) or complex posttraumatic stress disorder (complex PTSD) is designed to encompass long-standing symptoms not present in PTSD. An exploratory investigation of PTSD and DES NOS was performed with the Structured

  2. Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

    DEFF Research Database (Denmark)

    Harvey, Brian H; Oosthuizen, Frasia; Brand, Linda

    2004-01-01

    . The NOS isoform involved, and the role of stress-mediated corticosterone release in NOS activation, was verified with the administration of selective iNOS and nNOS inhibitors, aminoguanidine (50 mg/kg/day i.p.) and 7-nitroindazole (12.5 mg/kg/day i.p.), and the steroid synthesis inhibitor, ketoconazole...... (24 mg/kg/day i.p.), administered for 21 days prior to and during the stress procedure. RESULTS: Stress evoked a sustained increase in NOS activity, but reduced NMDA receptor density and total GABA levels. Aminoguanidine or ketoconazole, but not 7-nitroindazole or saline, blocked stress-induced NOS...

  3. Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta

    Directory of Open Access Journals (Sweden)

    Josiane Fernandes da Silva

    2016-09-01

    Full Text Available Background - The understanding of obsesity-related vascular dysfunction remains controversial mainly because of the diseases associated with vascular injury. Exercise training is known to prevent vascular dysfunction. Using an obesity model without comorbidities, we aimed at investigating the underlying mechanism of vascular dysfunction and how exercise interferes with this process.Methods - High-sugar diet was used to induce obesity in mice. Exercise training was performed 5 days/week. Body weight, energy intake, and adipose tissues were assessed; blood metabolic and hormonal parameters were determined; and serum TNFα was measured. Blood pressure and heart rate were assessed by plethysmography. Changes in aortic isometric tension were recorded on myograph. Western blot was used to analyze protein expression. Nitric oxide (NO was evaluated using fluorescence microscopy. Antisense oligodeoxynucleotides were used for inducible nitric oxide synthase isoform (iNOS knockdown.Results - Body weight, fat mass, total cholesterol, low-density lipoprotein cholesterol fraction, insulin, and leptin were higher in the sedentary obese group (SD than in the sedentary control animals (SS. Exercise training prevented these changes. No difference in glucose tolerance, insulin sensitivity, blood pressure, and heart rate was found. Decreased vascular relaxation and reduced endothelial nitric oxide synthase (eNOS functioning in the SD group were prevented by exercise. Contractile response to phenylephrine was decreased in the aortas of the wild SD mice, compared with that of the SS group; however, no alteration was noted in the SD iNOS-/- animals. The decreased contractility was endothelium-dependent, and was reverted by iNOS inhibition or iNOS silencing. The aortas from the SD group showed increased basal NO production, serum TNFα, TNF receptor-1, and phospho-IκB. Exercise training attenuated iNOS-dependent reduction in contractile response in high-sugar diet

  4. Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus.

    Science.gov (United States)

    Chachlaki, Konstantina; Malone, Samuel A; Qualls-Creekmore, Emily; Hrabovszky, Erik; Münzberg, Heike; Giacobini, Paolo; Ango, Fabrice; Prevot, Vincent

    2017-10-15

    Neurons expressing nitric oxide (NO) synthase (nNOS) and thus capable of synthesizing NO play major roles in many aspects of brain function. While the heterogeneity of nNOS-expressing neurons has been studied in various brain regions, their phenotype in the hypothalamus remains largely unknown. Here we examined the distribution of cells expressing nNOS in the postnatal and adult female mouse hypothalamus using immunohistochemistry. In both adults and neonates, nNOS was largely restricted to regions of the hypothalamus involved in the control of bodily functions, such as energy balance and reproduction. Labeled cells were found in the paraventricular, ventromedial, and dorsomedial nuclei as well as in the lateral area of the hypothalamus. Intriguingly, nNOS was seen only after the second week of life in the arcuate nucleus of the hypothalamus (ARH). The most dense and heavily labeled population of cells was found in the organum vasculosum laminae terminalis (OV) and the median preoptic nucleus (MEPO), where most of the somata of the neuroendocrine neurons releasing GnRH and controlling reproduction are located. A great proportion of nNOS-immunoreactive neurons in the OV/MEPO and ARH were seen to express estrogen receptor (ER) α. Notably, almost all ERα-immunoreactive cells of the OV/MEPO also expressed nNOS. Moreover, the use of EYFP Vglut2 , EYFP Vgat , and GFP Gad67 transgenic mouse lines revealed that, like GnRH neurons, most hypothalamic nNOS neurons have a glutamatergic phenotype, except for nNOS neurons of the ARH, which are GABAergic. Altogether, these observations are consistent with the proposed role of nNOS neurons in physiological processes. © 2017 Wiley Periodicals, Inc.

  5. Institucionalizacao da saude publica paulista nos anos 1930-1940

    Directory of Open Access Journals (Sweden)

    Andre Mota

    2013-10-01

    Full Text Available O objetivo do estudo foi interpretar e compreender a institucionalização da saúde pública paulista nos anos 1930-1940, com base na história das especialidades médicas. Foram analisadas novas fontes documentais em diálogo com a literatura existente, levando à identificação de novos indícios relativamente à questão eugênica e à presença de crenças religiosas de médicos como um movimento social. Os médicos, à medida que se especializavam como sanitaristas, propunham um projeto para elevar a raça brasileira, mesclando discursos higienistas com ações sanitárias. São Paulo buscou a primazia nesse projeto, por se acreditar um Estado detentor de uma raça já constituída de “homens historicamente saudáveis”. Crenças religiosas influenciaram o debate e as decisões de época para a ordem sanitária. Historicamente, o discurso sanitário compõe questões técnico-científicas com as político-ideológicas e as culturais, produzindo uma mescla dos diferentes interesses e perspectivas de ordem corporativa da profissão.

  6. Assédio moral nos ambientes corporativos

    Directory of Open Access Journals (Sweden)

    Yumara Lúcia Vasconcelos

    Full Text Available Resumo:Esse artigo teve como objetivo caracterizar o assédio moral nos ambientes corporativos à luz do paradigma conceitual do que se concebe como "dignidade humana" e violação do princípio jurídico da boa-fé. Especificamente, visou identificar padrões na argumentação jurídica e no enquadramento de práticas nocivas à saúde mental do trabalhador. O estudo, de natureza qualitativa, tomou por base o estudo de situações jurídicas, orientando-se pela demanda por definição e caracterização da prática assediadora no âmbito organizacional e dos limites do conceito da dignidade humana. Como principal resultado, o estudo colocou em contraste a necessidade de contextualização do fato propulsor da denúncia e caracterização do assédio, sem olvidar a relevância do significado ou sentido atribuído pelo indivíduo ao fenômeno analisado.

  7. Heterose em suínos na fase de aleitamento

    Directory of Open Access Journals (Sweden)

    José Bento Sterman Ferraz

    1991-12-01

    Full Text Available Visando avaliar o ganho de produtividade, advindo da heterose, no peso de suínos em fase de aleitamento, analisaram-se os pesos ao nascimento(PO, 21 dias de idade (P21 e desmama (PD de 746leitões, sendo 201 da raça Landrace, 136 Wessex-Saddleback e 409 mestiços, pelo método dos quadrados mínimos, considerando-se, ainda, os efeitos fixos de época e ano de nascimento, ordem do parto, sexo do leitão e tamanho da leitegada, além de raças paterna e materna e suas interações. Os efeitos não genéticos tiveram influência significativa em quase todas as características. Os mestiços mostraram, em geral, pesos superiores aos puros, com estimativas de heterose de 2,6% para PO, 9,7% para P21 e 13,9% para PD, indicando a importância da herança não aditiva à medida que os leitões ficam menos dependentes de suas mães. Os efeitos de interação entre as raças paterna e materna foram cada vez maiores com o avançar da idade. Os resultados indicam haver ganho de produtividade coma utilização deste tipo de cruzamento.

  8. Empirical support for a reclassification of eating disorders NOS.

    Science.gov (United States)

    Helverskov, J L; Lyng, B; Clausen, L; Mors, O; Frydenberg, M; Thomsen, P H; Rokkedal, K

    2011-01-01

    To explore the empirical support for a reclassification of the eating disorders NOS (EDNOS) category. In a cross-sectional design eight specific subgroups of EDNOS were compared to anorexia nervosa (AN) and bulimia nervosa (BN) on interview-based data and questionnaire measures. The sample consisted of 965 patients in the age 13-54 years admitted to treatment for an eating disorder. According to the DSM-IV 176(18%) presented with AN, 290(30%) with BN and 499(52%) with EDNOS. Of all EDNOS cases 34% could be reclassified as AN or BN. Three specific subgroups emerged as separate diagnostic entities. A heterogeneous subgroup of 122 patients (13% of all) was proposed as 'true' EDNOS. Implications of the results on the DSM-V are discussed. The results support a broader definition of AN and BN and suggest subgroups of EDNOS as separate diagnostic entities. This results in a substantial reduction of the heterogeneous EDNOS group. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.

  9. Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

    Science.gov (United States)

    Saldarriaga, Omar A.; Travi, Bruno L.; Choudhury, Goutam Ghosh; Melby, Peter C.

    2012-01-01

    IFN-γ/LPS-activated hamster (Mesocricetus auratus) macrophages express significantly less iNOS (NOS2) than activated mouse macrophages, which contributes to the hamster's susceptibility to intracellular pathogens. We determined a mechanism responsible for differences in iNOS promoter activity in hamsters and mice. The HtPP (1.2 kb) showed low basal and inducible promoter activity when compared with the mouse, and sequences within a 100-bp region (−233 to −133) of the mouse and hamster promoters influenced this activity. Moreover, within this 100 bp, we identified a smaller region (44 bp) in the mouse promoter, which recovered basal promoter activity when swapped into the hamster promoter. The mouse homolog (100-bp region) contained a cis-element for NF-IL-6 (−153/−142), which was absent in the hamster counterpart. EMSA and supershift assays revealed that the hamster sequence did not support the binding of NF-IL-6. Introduction of a functional NF-IL-6 binding sequence into the hamster promoter or its alteration in the mouse promoter revealed the critical importance of this transcription factor for full iNOS promoter activity. Furthermore, the binding of NF-IL-6 to the iNOS promoter (−153/−142) in vivo was increased in mouse cells but was reduced in hamster cells after IFN-γ/LPS stimulation. Differences in the activity of the iNOS promoters were evident in mouse and hamster cells, so they were not merely a result of species-specific differences in transcription factors. Thus, we have identified unique DNA sequences and a critical transcription factor, NF-IL-6, which contribute to the overall basal and inducible expression of hamster iNOS. PMID:22517919

  10. St36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats.

    Science.gov (United States)

    Almeida, R T; Galdino, G; Perez, A C; Silva, G; Romero, T R; Duarte, I D

    2017-02-01

    Orofacial pain is pain perceived in the face and/or oral cavity, generally caused by diseases or disorders of regional structures, by dysfunction of the nervous system, or through referral from distant sources. Treatment of orofacial pain is mainly pharmacological, but it has increased the number of reports demonstrating great clinical results with the use of non-pharmacological therapies, among them electroacupuncture. However, the mechanisms involved in the electroacupuncture are not well elucidated. Thus, the present study investigate the involvement of the nitric oxide synthase (NOS) and ATP sensitive K + channels (KATP) in the antinociception induced by electroacupuncture (EA) at acupoint St36. Thermal nociception was applied in the vibrissae region of rats, and latency time for face withdrawal was measured. Electrical stimulation of acupoint St36 for 20 minutes reversed the thermal withdrawal latency and this effect was maintained for 150 min. Intraperitoneal administration of specific inhibitors of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and a KATP channels blocker reversed the antinociception induced by EA. Furthermore, nitrite concentration in cerebrospinal fluid (CSF) and plasma, increased 4 and 3-fold higher, respectively, after EA. This study suggests that NO participates of antinociception induced by EA by nNOS, iNOS and ATP-sensitive K + channels activation.

  11. Draft environmental statement: Related to operation of the Edwin I. Hatch Nuclear Plant Unit No. 2, Georgia Power Company: Docket No. 50-366

    International Nuclear Information System (INIS)

    1977-04-01

    The proposed action is the issuance of an operation license to the Georgia Power Company for the startup and operation of the Edwin I. Hatch Nuclear Plant, Unit No. 2 (Docket No. 50-366), located on the Altamaha River in Appling County, approximately 11 miles north from Baxley, Georgia. The information in this Statement represents the second, assessment of the environmental impact associated with the Edwin I. Hatch Nuclear Plant, Unit No. 2, pursuant to the guidelines of the National Environmental Policy Act of 1969 (NEPA) and 10 CFR Part 51 of the Commission's Regulations. After receipt of an application, in 1970, to construct this plant, the staff carried out a review of impact that would occur during the construction and operation of this plant. That evaluation was issued as a Final Environmental Statement in October 1972. As the result of that environmental review, a safety review, an evaluation by the Advisory Committee on Reactor Safeguards, and a public hearing in Baxley, Georgia and Washington, D.C., the AEC (now NRC) issued a permit in December 1972, for the construction of Unit No. 2 of the Edwin I. Hatch Nuclear Plant. As of February 1977, the construction of Unit No. 2 was 70% complete. With a proposed fuel-loading date of April 1978 for Unit No. 2, the applicant has petitioned for license to operate Unit No. 2 and has submitted (July 1975) the required safety and environmental reports to substantiate this petition. 97 refs., 18 figs., 37 tabs

  12. Safety Evaluation Report related to the operation of Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410). Supplement No. 5

    International Nuclear Information System (INIS)

    1986-10-01

    This report supplements the Safety Evaluation Report (NUREG-1047, February 1985) for the application filed by Niagara Mohawk Power Corporation, as applicant and co-owner, for a license to operate Nine Mile Point Nuclear Station, Unit 2 (Docket No. 50-410). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near Oswego, New York. Supplement 1 to the Safety Evaluation Report was published in June 1985 and contained the report from the Advisory Committee on Reactor Safeguards as well as the resolution of a number of outstanding issues from the Safety Evaluation Report. Supplement 2 was published in November 1985 and contained the resolution of a number of outstanding and confirmatory issues. Supplement 3 was published in July 1986 and contained the resolution of a number of outstanding and confirmatory items, one new confirmatory item, the evaluation of the Engineering Assurance Program, and the evaluation of a number of exemption requests. Supplement 4 was published in September 1986 and contained the resolution of a number of outstanding and confirmatory issues and the evaluation of a number of exemption requests. This report contains the resolution of a number of issues that have been resolved since Supplement 4 was issued. It also contains the evaluation of a number of requests for exemption from the applicant. This report also supports the issuance of the low-power license for Nine Mile Point Nuclear Station, Unit 2

  13. Effects of natural phenomena on the Babcock and Wilcox Co. Plutonium Fabrication Plant at the Parks Township site, Leechburg, Pennsylvania. Docket No. 70-364

    International Nuclear Information System (INIS)

    1979-03-01

    The proposed action is to issue a renewal to the full-term Special Nuclear Material License No. SNM-414 (Docket No. 70-364) authorizing the Nuclear Material Division of the Babcock and Wilcox Company (BandW) to operate nuclear-fuel-fabrication facilities located in Leechburg, Pennsylvania. The plutonium fuel facility is presently being used to fabricate fuel for the fast test reactor under construction at the Hanford Reservation near Richland, Washington. Implicit in Sections 70.22 and 70.23 of 10CFR70 is a requirement that existing plutonium fabrication plants be examined with the objective of improving, to the extent practicable, their abilities to withstand adverse natural phenomena without loss of capability to protect the public. In accordance with these regulations, an analysis was initiated of the effects of natural phenomena on the BandW Plutonium Fabrication Plant. Following completion of the analysis, a condensation was prepared of the effects of natural phenomena on the facility

  14. Safety evaluation report related to the preliminary design of the Standard Nuclear Steam Supply Reference System, RESAR SP/90 (Docket No. STN 50-601)

    International Nuclear Information System (INIS)

    1991-04-01

    On October 24, 1983, the Westinghouse Electric Corporation tendered its application for a preliminary design approval of the advanced pressurized-water reactor design for the SP/90 reactor. The Westinghouse Reference Safety Analysis Report (RESAR SP/90, Docket No. STN 50-601), describing the design of the facility, was submitted from October 24, 1983 through March 9, 1987. Staff of the US Nuclear Regulatory Commission, Office of Nuclear Reactor Regulation, has prepared this safety evaluation report of the RESAR SP/90 on the basis of its review. Because of the stage of the design, there are open issues that have not been resolved. These issues are discussed in detail throughout this report, and a summary is provided in Section 1.6 of this report. The applicant will be required to address these and any additional such concerns that may be raised during the course of the staff's review of advanced light-water reactors in support of a final design approval application. This report shall not constitute a commitment to issue a permit or license or in any way affect the authority of the Commission, its adjudicatory boards, and other presiding officers in any proceeding under Subpart G of Title 10 of the Code of Federal Regulations, Part 2

  15. Safety Evaluation Report related to the operation of Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410). Supplement No. 4

    International Nuclear Information System (INIS)

    1986-09-01

    This report supplements the Safety Evaluation Report (NUREG-1047, February 1985) for the application filed by Niagara Mohawk Power Corporation, as applicant and co-owner, for a license to operate Nine Mile Point Nuclear Station, Unit 2 (Docket No. 50-410). It has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located near Oswego, New York. Supplement 1 to the Safety Evaluation Report was published in June 1985, and contained the report from the Advisory Committee on Reactor Safeguards as well as the resolution of a number of outstanding issues from the Safety Evaluation Report. Supplement 2 was published in November 1985, and contained the resolution of a number of outstanding and confirmatory issues. Supplement 3 was published in July 1986, and contained the resolution of a number of outstanding and confirmatory items, one new confirmatory item, the evaluation of the Engineering Assurance Program, and evaluation of a number of exemption requests

  16. Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats

    Directory of Open Access Journals (Sweden)

    Hye Suk Hwang

    2011-01-01

    Full Text Available Using spontaneously hypertensive rats (SHR, this study investigated whether electroacupuncture (EA could reduce early stage hypertension by examining nitric oxide (NO levels in plasma and nitric oxide synthase (NOS levels in the mesenteric resistance artery. EA was applied to the acupuncture point Governor Vessel 20 (GV20 or to a non-acupuncture point in the tail twice weekly for 3 weeks under anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY rats, blood pressure was determined the day after EA treatment by the tail-cuff method. We measured plasma NO concentration, and evaluated endothelial NO syntheses (eNOS and neuronal NOS (nNOS protein expression in the mesenteric artery. Systolic blood pressure (SBP and diastolic blood pressure (DBP were lower after 3 weeks of GV20 treatment than EA at non-acupuncture point and no treatment control in SHR. nNOS expression by EA was significantly different between both WKY and no treatment SHR control, and EA at GV20 in SHR. eNOS expression was significantly high in EA at GV 20 compared with no treatment control. In conclusion, EA could attenuate the blood pressure elevation of SHR, along with enhancing NO/NOS activity in the mesenteric artery in SHR.

  17. Identification and molecular characterization of nitric oxide synthase (NOS) gene in the intertidal copepod Tigriopus japonicus.

    Science.gov (United States)

    Jeong, Chang-Bum; Kang, Hye-Min; Seo, Jung Soo; Park, Heum Gi; Rhee, Jae-Sung; Lee, Jae-Seong

    2016-02-10

    In copepods, no information has been reported on the structure or molecular characterization of the nitric oxide synthase (NOS) gene. In the intertidal copepod Tigriopus japonicus, we identified a NOS gene that is involved in immune responses of vertebrates and invertebrates. In silico analyses revealed that nitric oxide (NO) synthase domains, such as the oxygenase and reductase domains, are highly conserved in the T. japonicus NOS gene. The T. japonicus NOS gene was highly transcribed in the nauplii stages, implying that it plays a role in protecting the host during the early developmental stages. To examine the involvement of the T. japonicus NOS gene in the innate immune response, the copepods were exposed to lipopolysaccharide (LPS) and two Vibrio sp. After exposure to different concentrations of LPS and Vibrio sp., T. japonicus NOS transcription was significantly increased over time in a dose-dependent manner, and the NO/nitrite concentration increased as well. Taken together, our findings suggest that T. japonicus NOS transcription is induced in response to an immune challenge as part of the conserved innate immunity. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

    Directory of Open Access Journals (Sweden)

    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  19. (INTERSUBJETIVIDADE NOS ESTUDOS DE REDES SOCIAIS: DISSOLVENDO FRONTEIRAS

    Directory of Open Access Journals (Sweden)

    Sayonara Costa

    2014-07-01

    Full Text Available As redes sociais da internet (RSI se multiplicam e todas elas, embora tenham esquemas enunciativos distintos, ampliam as possibilidades de por em cena (intersubjetividades. Muitos papeis sociais são desempenhados nesses ambientes digitais que dão guarida às múltiplas faces de um sujeito que se (desconstrói em meio a um processo heterogêneo. Diante disso, a pergunta que norteia esse ensaio é: Como estudar esse processo de (desconstrução da subjetividade em redes sociais? A proposição que defendemos neste trabalho é a de que o sujeito adepto das redes sociais da internet encontra-se em um tempo-espaço propício a excitações que vão muito além das percepções idiossincráticas de cada indivíduo. Em função disso, propomos que estudar as (intersubjetividades nas RSI pode ser produtivo se relacionarmos as noções de caosmose (Guattari, self (Goffman e enunciação linguística (Benveniste. A conclusão a que chegamos é a de que o viés da enunciação linguística pode ser uma alternativa metodológica que auxilie na conexão entre uma concepção mais transversalista da subjetividade e a tese de que a interação social assemelha-se a uma encenação teatral e, por isso, pode tomar rumos diversos, de acordo com roteiros pré-estabelecidos e socialmente partilhados nos cenários digitais das RSI.

  20. Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis.

    Science.gov (United States)

    Zhang, Guannan; Li, Xiaodong; Sheng, Chengyu; Chen, Xiaohui; Chen, Yu; Zhu, Dingliang; Gao, Pingjin

    2016-12-30

    A large amount of NO is generated through the inducible nitric oxide synthase (iNOS) pathway from the vascular adventitia in various vascular diseases. However, it is currently not fully understood how the iNOS signaling pathway is activated. In the present study, this question was addressed in the context of adventitial cellular interactions. A rat model of acute hypertension in the contralateral carotid arteries was established through transverse aortic constriction (TAC) surgery. In this model, activated macrophages were found surrounded by a large quantity of iNOS-expressing adventitial fibroblasts (AFs), suggesting a possible causal relationship between macrophages and iNOS activation of the neighboring AFs. In an in vitro model, a macrophage-like cell line RAW 264.7 was first activated by LPS treatment. The supernatant was then harvested and applied to treat primary rat AFs. iNOS in AFs was activated robustly by the supernatant treatment but not by LPS itself. Treating AFs with interleukin-1β (IL-1β) also activated iNOS signaling, suggesting that the IL-1β pathway might be a possible mediator. As a consequence of the iNOS activation, total protein nitration and S-nitrosylation significantly increased in those AFs. Additionally, increased deposition of type I and type III collagens was observed in both in vitro and in vivo models. The collagen deposition was partially restored by an iNOS inhibitor, 1400 W. These findings highlight the importance of iNOS signaling during vascular inflammation, and advance our understanding of its activation through a cellular interaction perspective. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

    Science.gov (United States)

    Sasaki, Mari; Shinozaki, Shohei; Morinaga, Hironobu; Kaneki, Masao; Nishimura, Emi; Shimokado, Kentaro

    2018-07-02

    Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). We observed that ob/ob; iNOS-KO mice were potentiated for the transition from telogen (rest phase) to anagen (growth phase) in the hair cycle compared with iNOS-proficient ob/ob mice. To determine the effect of nitric oxide (NO) on the hair cycle, we administered an iNOS inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) or topically (10% aminoguanidine) in ob/ob mice. We observed that iNOS inhibitors promoted anagen transition in ob/ob mice. Next, we administered an NO donor (S-nitrosoglutathione, GSNO), to test whether NO has the telogen elongation effects. The NO donor was sufficient to induce telogen elongation in wild-type mice. Together, our data indicate that iNOS-derived NO plays a role in telogen elongation under the inflammatory conditions associated with diabetes in mice. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  2. História e oralidade nos estudos comunicacionais

    Directory of Open Access Journals (Sweden)

    Juniele Rabêlo Almeida

    2016-05-01

    Full Text Available Concepções, métodos e formas do conhecimento histórico são expressos em diversos estudos na área de comunicação social. Buscamos analisar, na interface história e narrativa oral, aspectos da chamada mediação cultural, na qual a comunicação está para além da condição de canal. Acreditamos que os estudos comunicacionais não recaem, necessariamente, sobre especificidades técnicas, mas sobre a posição que a comunicação assume no campo histórico-cultural. Interações, expressas nos trabalhos de história oral, se configuram (e resultam em processos comunicacionais que indicam construções sócio históricas e diferentes referenciais de pertencimento. Palavras-chave: Estudos comunicacionais, História, Narrativas Orais.   Abstract: Conceptions, methods and historical knowledge forms are expressed in several studies in the area of social communication. We analyze, history and oral narrative interface, called aspects of cultural mediation, in which the communication is in addition to the channel condition. We believe that communication studies do not fall necessarily on technicalities, but on the position that the communication is in the historical-cultural field. Interactions, expressed in the works of oral history, are configured (and result in communication processes that indicate historical social constructions and different frames of belonging. Keywords: communication Studies, History, Oral Narratives.   Resumen: Conceptos, métodos y formas de conocimiento histórico se expresan en varios estudios en el área de la comunicación social. Analizamos, la historia y la interfaz de la narrativa oral, llamados aspectos de mediación cultural, en el que la comunicación es, además de la condición de canal. Creemos que los estudios de comunicación no caen necesariamente en técnicos, sino a la posición de que la comunicación es en el campo histórico-cultural. Interacciones, expresados en las obras de la historia oral, est

  3. NOS CO-OPS Water Level Data, High Low Tide Prediction

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  4. NOS CO-OPS Water Level Data, Tide Prediction, 60-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  5. NODC Standard Format NOS Coastal Wave Program (F182) Data (1979-1983) (NODC Accession 0014203)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data type was designed for analyzed wave data originating from the National Ocean Service (NOS) Coastal Wave Program. The data are organized into 3 record...

  6. NOS CO-OPS Water Level Data, Tide Prediction, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  7. Final supplement to the final environmental statement related to operation of Three Mile Island Nuclear Station, Unit 2: (Docket No. 50-320)

    International Nuclear Information System (INIS)

    1976-12-01

    The proposed action is the continuation of construction permit CPPR-66 and the issuance of operating license to Metropolitan Edison Company, Jersey Central Power and Light Company, and the Pennsylvania Electric Company (the Applicants) for the operation of the Three Mile Island Nuclear Station, Unit 2, Docket No. 50-320, near Harrisburg in Dauphin County, Pennsylvania. The Three Mile Island Nuclear Station Unit Number 2 has a designed thermal rating of 2772 megawatts with a maximum electrical output of 959 megawatts. Two natural draft cooling towers are utilized for dissipating the waste heat from the closed cycle cooling system. Extension of TMINS-Bechtelsville 500 kV transmission line an additional 7.36 miles from Bechtelsville to Hosensack required acquisition of additional 175 foot wide right-of-way along an existing 150 foot wide 230 kV corridor. Construction of this line segment resulted in clearing of 21 acres of woodland, spanning over 134.5 acres of agricultural land and diverting of 0.4 acres from agriculture to use under tower bases. About 550 curies of radionuclides in liquid effluents (0.24 Ci/yr excluding tritium and 550 Ci/yr of tritium) will be released to the environment annually. Gaseous releases will be approximately 6700 Ci/yr of noble gases, 0.01 Ci/yr of iodine-131, 560 Ci/yr of tritium, 25 Ci/yr of argon-41, and 0.06 Ci/yr of particulates. No significant environmental impacts are anticipated from normal operational releases of radioactive materials. The calculated dose to the estimated year 1990 US population is less than 540 manrem/yr. This value is less than the natural fluctuation in the approximately 28,000,000 manrem/yr dose this population would receive from background radiation

  8. Endogenous angiotensin II modulates nNOS expression in renovascular hypertension

    Directory of Open Access Journals (Sweden)

    T.M.C. Pereira

    2009-07-01

    Full Text Available Nitric oxide (NO influences renal blood flow mainly as a result of neuronal nitric oxide synthase (nNOS. Nevertheless, it is unclear how nNOS expression is modulated by endogenous angiotensin II, an inhibitor of NO function. We tested the hypothesis that the angiotensin II AT1 receptor and oxidative stress mediated by NADPH oxidase contribute to the modulation of renal nNOS expression in two-kidney, one-clip (2K1C hypertensive rats. Experiments were performed on male Wistar rats (150 to 170 g body weight divided into 2K1C (N = 19 and sham-operated (N = 19 groups. nNOS expression in kidneys of 2K1C hypertensive rats (N = 9 was compared by Western blotting to that of 2K1C rats treated with low doses of the AT1 antagonist losartan (10 mg·kg-1·day-1; N = 5 or the superoxide scavenger tempol (0.2 mmol·kg-1·day-1; N = 5, which still remain hypertensive. After 28 days, nNOS expression was significantly increased by 1.7-fold in the clipped kidneys of 2K1C rats and by 3-fold in the non-clipped kidneys of 2K1C rats compared with sham rats, but was normalized by losartan. With tempol treatment, nNOS expression increased 2-fold in the clipped kidneys and 1.4-fold in the non-clipped kidneys compared with sham rats. The changes in nNOS expression were not followed by changes in the enzyme activity, as measured indirectly by the cGMP method. In conclusion, AT1 receptors and oxidative stress seem to be primary stimuli for increased nNOS expression, but this up-regulation does not result in higher enzyme activity.

  9. Angiotensin II blockade causes acute renal failure in eNOS-deficient mice

    Directory of Open Access Journals (Sweden)

    Jürgen Schnermann

    2001-03-01

    Full Text Available Compared with wild-type mice, adult endothelial nitric oxide synthase (eNOS knockout mice (eight months of age have increased blood pressure (BP (126±9 mmHg vs. 100±4 mmHg, and an increased renal vascular resistance (155±16 vs. 65±4 mmHg.min/ml. Renal vascular resistance responses to i.v. administration of noradrenaline were markedly enhanced in eNOS knockout mice. Glomerular filtration rate (GFR of anaesthetised eNOS -/- mice was 324±57 µl/min gKW, significantly lower than the GFR of 761±126 µl/min.gKW in wild-type mice. AT1-receptor blockade with i.v. candesartan (1—1.5 mg/kg reduced arterial blood pressure and renal vascular resistance, and increased renal blood flow (RBF to about the same extent in wild-type and eNOS -/- mice. Candesartan did not alter GFR in wild-type mice (761±126 vs. 720±95 µl/min.gKW, but caused a marked decrease in GFR in eNOS -/- mice (324.5±75.2 vs. 77±18 µl/min.gKW. A similar reduction in GFR of eNOS deficient mice was also caused by angiotensin-converting enzyme (ACE inhibition. Afferent arteriolar granularity, a measure of renal renin expression, was found to be reduced in eNOS -/- compared with wild-type mice. In chronically eNOS-deficient mice, angiotensin II (Ang II is critical for maintaining glomerular filtration pressure and GFR, presumably through its effect on efferent arteriolar tone.

  10. A central role of eNOS in the protective effect of wine against metabolic syndrome.

    Science.gov (United States)

    Leighton, Federico; Miranda-Rottmann, Soledad; Urquiaga, Inés

    2006-01-01

    The positive health effects derived from moderate wine consumption are pleiotropic. They appear as improvements in cardiovascular risk factors such as plasma lipids, haemostatic mechanisms, endothelial function and antioxidant defences. The active principles would be ethanol and mainly polyphenols. Results from our and other laboratories support the unifying hypothesis that the improvements in risk factors after red wine consumption are mediated by endothelial nitric oxide synthase (eNOS). Many genes are involved, but the participation of eNOS would be a constant feature. The metabolic syndrome is a cluster of metabolic risk factors associated with high risk of cardiovascular disease (CVD). The National Cholesterol Education Programmmes Adult Treatment Panel III (NCEPATP III) clinical definition of the metabolic syndrome requires the presence of at least three risk factors, from among abdominal obesity, high plasma triacylglycerols, low plasma HDL, high blood pressure and high fasting plasma glucose. The molecular mechanisms responsible for the metabolic syndrome are not known. Since metabolic syndrome apparently affects 10-30% of the population in the world, research on its pathogenesis and control is needed. The recent finding that eNOS knockout mice present a cluster of cardiovascular risk factors comparable to those of the metabolic syndrome suggests that defects in eNOS function may cause human metabolic syndrome. These mice are hypertensive, insulin resistant and dyslipidemic. Further support for a pathogenic role of eNOS comes from the finding in humans that eNOS polymorphisms associate with insulin resistance and diabetes, with hypertension, with inflammatory and oxidative stress markers and with albuminuria. So, the data sustain the hypothesis that eNOS enhancement should reduce metabolic syndrome incidence and its consequences. Therefore red wine, since it enhances eNOS function, should be considered as a potential tool for the control of metabolic

  11. Activation of Endothelial Nitric Oxide (eNOS Occurs through Different Membrane Domains in Endothelial Cells.

    Directory of Open Access Journals (Sweden)

    Jason Tran

    Full Text Available Endothelial cells respond to a large range of stimuli including circulating lipoproteins, growth factors and changes in haemodynamic mechanical forces to regulate the activity of endothelial nitric oxide synthase (eNOS and maintain blood pressure. While many signalling pathways have been mapped, the identities of membrane domains through which these signals are transmitted are less well characterized. Here, we manipulated bovine aortic endothelial cells (BAEC with cholesterol and the oxysterol 7-ketocholesterol (7KC. Using a range of microscopy techniques including confocal, 2-photon, super-resolution and electron microscopy, we found that sterol enrichment had differential effects on eNOS and caveolin-1 (Cav1 colocalisation, membrane order of the plasma membrane, caveolae numbers and Cav1 clustering. We found a correlation between cholesterol-induced condensation of the plasma membrane and enhanced high density lipoprotein (HDL-induced eNOS activity and phosphorylation suggesting that cholesterol domains, but not individual caveolae, mediate HDL stimulation of eNOS. Vascular endothelial growth factor (VEGF-induced and shear stress-induced eNOS activity was relatively independent of membrane order and may be predominantly controlled by the number of caveolae on the cell surface. Taken together, our data suggest that signals that activate and phosphorylate eNOS are transmitted through distinct membrane domains in endothelial cells.

  12. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis

    International Nuclear Information System (INIS)

    Parhad, Swapnil S.; Jaiswal, Deepa; Ray, Krishanu; Mazumdar, Shyamalava

    2016-01-01

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in L-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. - Highlights: • The effect of interaction of nNOS with DLC1 has been debatable with contradicting reports in literature. • Purified DLC1 has no effect on electron transport between reductase and oxygenase domain of purified nNOS-CaM. • The NO release activity of nNOS was not altered by DLC1, supporting that DLC1 does not inhibit the enzyme. • These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell.

  13. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Parhad, Swapnil S. [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); Jaiswal, Deepa [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); TIFR Centre for Interdisciplinary Sciences, 21 Brundavan Colony, Narsingi, Hyderabad 500075 (India); Ray, Krishanu, E-mail: krishanu@tifr.res.in [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); Mazumdar, Shyamalava, E-mail: shyamal@tifr.res.in [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India)

    2016-03-25

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in L-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. - Highlights: • The effect of interaction of nNOS with DLC1 has been debatable with contradicting reports in literature. • Purified DLC1 has no effect on electron transport between reductase and oxygenase domain of purified nNOS-CaM. • The NO release activity of nNOS was not altered by DLC1, supporting that DLC1 does not inhibit the enzyme. • These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell.

  14. Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway

    Energy Technology Data Exchange (ETDEWEB)

    Nagane, Masaki; Yasui, Hironobu; Sakai, Yuri; Yamamori, Tohru [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 (Japan); Niwa, Koichi [Laboratory of Biochemistry, Department of Food and Cosmetic Science, Faculty of Bioindustry, Tokyo University of Agriculture, Abashiri 099-2493 (Japan); Hattori, Yuichi [Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 (Japan); Kondo, Takashi [Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 (Japan); Inanami, Osamu, E-mail: inanami@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 (Japan)

    2015-01-02

    Highlights: • eNOS activity is increased in BAECs exposed to X-rays. • ATM is involved in this increased eNOS activity. • HSP90 modulates the radiation-induced activation of ATM and eNOS. - Abstract: In this study, the involvement of ataxia telangiectasia mutated (ATM) kinase and heat shock protein 90 (HSP90) in endothelial nitric oxide synthase (eNOS) activation was investigated in X-irradiated bovine aortic endothelial cells. The activity of nitric oxide synthase (NOS) and the phosphorylation of serine 1179 of eNOS (eNOS-Ser1179) were significantly increased in irradiated cells. The radiation-induced increases in NOS activity and eNOS-Ser1179 phosphorylation levels were significantly reduced by treatment with either an ATM inhibitor (Ku-60019) or an HSP90 inhibitor (geldanamycin). Geldanamycin was furthermore found to suppress the radiation-induced phosphorylation of ATM-Ser1181. Our results indicate that the radiation-induced eNOS activation in bovine aortic endothelial cells is regulated by ATM and HSP90.

  15. Outcome after BCG treatment for urinary bladder cancer may be influenced by polymorphisms in the NOS2 and NOS3 genes.

    Science.gov (United States)

    Ryk, Charlotta; Koskela, Lotta Renström; Thiel, Tomas; Wiklund, N Peter; Steineck, Gunnar; Schumacher, Martin C; de Verdier, Petra J

    2015-12-01

    Bacillus Calmette-Guérin (BCG)-treatment is an established treatment for bladder cancer, but its mechanisms of action are not fully understood. High-risk non-muscle invasive bladder-cancer (NMIBC)-patients failing to respond to BCG-treatment have worse prognosis than those undergoing immediate radical cystectomy and identification of patients at risk for BCG-failure is of high priority. Several studies indicate a role for nitric oxide (NO) in the cytotoxic effect that BCG exerts on bladder cancer cells. In this study we investigated whether NO-synthase (NOS)-gene polymorphisms, NOS2-promoter microsatellite (CCTTT)n, and the NOS3-polymorphisms-786T>C (rs2070744) and Glu298Asp (rs1799983), can serve as possible molecular markers for outcome after BCG-treatment for NMIBC. All NMIBC-patients from a well-characterized population based cohort were analyzed (n=88). Polymorphism data were combined with information from 15-years of clinical follow-up. The effect of BCG-treatment on cancer-specific death (CSD), recurrence and progression in patients with varying NOS-genotypes were studied using Cox proportional hazard-models and log rank tests. BCG-treatment resulted in significantly better survival in patients without (Log rank: p=0.006; HR: 0.12, p=0.048), but not in patients with a long version ((CCTTT)n ≧13 repeats) of the NOS2-promoter microsatellite. The NOS3-rs2070744(TT) and rs1799983(GG)-genotypes showed decreased risk for CSD (Log rank(TT): p=0.001; Log rank(GG): p=0.010, HR(GG): 0.16, p=0.030) and progression (Log rank(TT): p<0.001, HR(TT): 0.05, p=0.005; Log rank(GG): p<0.001, HR(GG): 0.10, p=0.003) after BCG-therapy compared to the other genotypes. There was also a reduction in recurrence in BCG-treated patients that was mostly genotype independent. Analysis of combined genotypes identified a subgroup of 30% of the BCG-treated patients that did not benefit from BCG-treatment. Our results suggest that the investigated polymorphisms influence patient response

  16. iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats.

    Directory of Open Access Journals (Sweden)

    Olof Schreiber

    Full Text Available AIM: To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease. METHODS: Colitis was induced with 5% DSS in drinking water for 8 days prior to experiment, when the descending colonic mucosa of anesthetized rats was studied using intravital microscopy. Mucus thickness was measured with micropipettes attached to a micromanipulator. To assess the contributions of NOS and prostaglandins in the regulation of colonic mucus thickness, the non-selective NOS-inhibitor L-NNA (10 mg/kg bolus followed by 3 mg/kg/h, the selective iNOS-inhibitor L-NIL (10 mg/kg bolus followed by 3 mg/kg/h and the non-selective COX-inhibitor diclofenac (5 mg/kg were administered intravenously prior to experiment. To further investigate the role of iNOS in the regulation of colonic mucus thickness, iNOS -/- mice were used. RESULTS: Colitic rats had a thicker firmly adherent mucus layer following 8 days of DSS treatment than untreated rats (88±2 µm vs 76±1 µm. During induction of colitis, the thickness of the colonic mucus layer initially decreased but was from day 3 significantly thicker than in untreated rats. Diclofenac reduced the mucus thickness similarly in colitic and untreated rats (-16±5 µm vs -14±2 µm. While L-NNA had no effect on colonic mucus thickness in DSS or untreated controls (+3±2 µm vs +3±1 µm, L-NIL reduced the mucus thickness significantly more in colitic rats than in controls (-33±4 µm vs -10±3 µm. The importance of iNOS in regulating the colonic mucus thickness was confirmed in iNOS-/- mice, which had thinner colonic mucus than wild-type mice (35±3 µm vs 50±2 µm, respectively. Furthermore, immunohistochemistry revealed increased levels of iNOS in the colonic surface epithelium following DSS treatment. CONCLUSION: Both prostaglandins and nitric oxide regulate basal colonic mucus thickness. During onset of colitis, the thickness of the mucus layer is initially reduced followed by an iNOS

  17. High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex

    DEFF Research Database (Denmark)

    Lauridsen, J K; Olesen, R H; Vendelbo, J

    2017-01-01

    unknown. Therefore we aim to examine the relationship between BMI and gene expression of central inflammatory markers in the human frontal cortex. Microarray data of 141 neurologically and psychiatrically healthy individuals were obtained through the BrainCloud database. A simple linear regression...... correlated (Plinear regression analyses with BMI, age, sex and race as variables were performed in order to identify potential confounders. In conclusion, increasing BMI could affect the IL10-mediated anti...... analysis was performed with BMI as variable on data on IL10, IL1β, IL6, PTGS2 (COX2) and NOS2 (iNOS). Increasing BMI is associated with a decrease in the mRNA expression of IL10 (P=0.014) and an increase in the expression of NOS2 (iNOS; P=0.040). Expressions of IL10 and NOS2 (iNOS) were negatively...

  18. High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex

    DEFF Research Database (Denmark)

    Lauridsen, J K; Olesen, R H; Vendelbo, J

    2017-01-01

    analysis was performed with BMI as variable on data on IL10, IL1β, IL6, PTGS2 (COX2) and NOS2 (iNOS). Increasing BMI is associated with a decrease in the mRNA expression of IL10 (P=0.014) and an increase in the expression of NOS2 (iNOS; P=0.040). Expressions of IL10 and NOS2 (iNOS) were negatively...... correlated (PIL10 was mostly affected by individuals with BMI ⩾40. Multiple linear regression analyses with BMI, age, sex and race as variables were performed in order to identify potential confounders. In conclusion, increasing BMI could affect the IL10-mediated anti...

  19. TERMOS AMBIENTAIS E SOCIAIS NOS RELATÓRIOS DA ADMINISTRAÇÃO

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2012-07-01

    Full Text Available O estudo objetiva verificar a tendência dos termos ambientais e sociais evidenciados nos relatórios da administração de 1997 a 2006 de empresas familiares brasileiras. Realizou-se pesquisa exploratória, com abordagem qualitativa, por meio de pesquisa documental e da técnica de análise de conteúdo nos RA de 1997 a 2006. No universo das 500 maiores empresas listadas na Revista Exame, edição 2006, identificaram-se 21 empresas familiares de capital aberto e de controle acionário brasileiro, mas dessas somente 16 publicaram seu RA nos dez anos considerados. Os resultados mostram que a oscilação na quantidade de páginas dos RA ao longo dos anos apresenta relação com algum evento ocorrido nas empresas. A evidenciação dos termos ambientais está mais relacionada às medidas tomadas para cuidar e preservar o meio ambiente do que aos passivos ambientais. A evidenciação dos termos sociais foi direcionada de maneira equilibrada ao público interno e externo. Conclui-se que há uma tendência nos termos ambientais e sociais evidenciados nos RA de 1997 a 2006 das empresas pesquisadas, ainda que tenham sido incorporados vários termos novos ao longo do período.

  20. Population structure from NOS genes correlates with geographical differences in coronary incidence across Europe.

    Science.gov (United States)

    Carreras-Torres, Robert; Ferran, Albert; Zanetti, Daniela; Esteban, Esther; Varesi, Laurent; Pojskic, Naris; Coia, Valentina; Chaabani, Hassen; Via, Marc; Moral, Pedro

    2016-12-01

    The population analysis of cardiovascular risk and non-risk genetic variation can help to identify adaptive or random demographic processes that shaped coronary incidence variation across geography. In this study, 114 single nucleotide polymorphisms and 17 tandem repeat polymorphisms from Nitric Oxide Synthases (NOS) regions were analyzed in 1686 individuals from 35 populations from Europe, North Africa, and the Middle East. NOS genes encode for key enzymes on nitric oxide availability, which is involved in several cardiovascular processes. These genetic variations were used to test for selection and to infer the population structure of NOS regions. Moreover, we tested whether the variation in the incidence of coronary events and in the levels of classical risk factors in 11 of these European populations could be explained by the population structure estimates. Our results supported, first, the absence of clear signs of selection for NOS genetic variants associated with cardiovascular diseases, and second, the presence of a continuous genetic pattern of variation across European and North African populations without a Mediterranean barrier for gene flow. Finally, population structure estimates from NOS regions are closely correlated with coronary event rates and classical risk parameters (explaining 39-98%) among European populations. Our results reinforce the hypothesis that genetic bases of cardiovascular diseases and associated complex phenotypes could be geographically shaped by random demographic processes. © 2016 Wiley Periodicals, Inc.

  1. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.

    Science.gov (United States)

    Morelatto, Rosana; Itoiz, María-Elina; Guiñazú, Natalia; Piccini, Daniel; Gea, Susana; López-de Blanc, Silvia

    2014-05-01

    The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.

  2. Expression of leptin and iNOS in oral melanomas in dogs.

    Science.gov (United States)

    Greene, V R; Wilson, H; Pfent, C; Roethele, J; Carwile, J; Qin, Y; Grimm, E; Ellerhorst, J A

    2013-01-01

    Oral melanoma (OM) in dogs is an aggressive malignancy, with clinical behavior resembling cutaneous melanomas in humans. Melanoma in humans is promoted by an inflammatory environment that is contributed to by leptin and inducible nitric oxide synthase (iNOS). To determine if the patterns of leptin and iNOS expression are similar in OM in dogs and cutaneous melanomas in humans. Twenty client-owned dogs. Retrospective case study. Immunostaining of the OM tumors from each dog was scored for percentage and intensity of leptin and iNOS expression. Mitotic index was used as an indicator of tumor aggression. Leptin was detected in ≥75% of the tumor cells in specimens from 11 dogs. One tumor expressed leptin in ≤25% of the cells. The intensity of leptin expression was variable with 6, 9, and 5 cases exhibiting low-, moderate-, and high-intensity staining, respectively. OM with the lowest percentage of iNOS positive cells displayed the highest mitotic indices (P = .006, ANOVA). The expression of leptin is a common finding in melanomas in dogs. These data suggest that the possibility of future clinical applications, such as measuring the concentrations of plasma leptin as a screening tool or leptin as a target for therapy. The relevance of iNOS is not as clear in dogs with OM, for which other directed therapeutics might be more appropriate. Copyright © 2013 by the American College of Veterinary Internal Medicine.

  3. Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale.

    Science.gov (United States)

    Canuto, Alessandra; Rudhard-Thomazic, Valérie; Herrmann, François R; Delaloye, Christophe; Giannakopoulos, Panteleimon; Weber, Kerstin

    2009-08-15

    To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.

  4. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

    Science.gov (United States)

    Cassini-Vieira, Puebla; Araújo, Fernanda Assis; da Costa Dias, Filipi Leles; Russo, Remo Castro; Andrade, Silvia Passos; Teixeira, Mauro Martins; Barcelos, Luciola Silva

    2015-01-01

    There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined. The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated. Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS−/−) and wild-type (WT) mice. The hemoglobin content and number of vessels were decreased in the implants of iNOS−/− mice compared to WT mice 14 days after implantation. VEGF levels were also reduced in the implants of iNOS−/− mice. In contrast, the iNOS−/− implants exhibited an increased neutrophil and macrophage infiltration. However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively. Furthermore, the implants of iNOS−/− mice showed boosted collagen deposition. These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice. PMID:26106257

  5. Modulation of liver mitochondrial NOS is implicated in thyroid-dependent regulation of O(2) uptake.

    Science.gov (United States)

    Carreras, M C; Peralta, J G; Converso, D P; Finocchietto, P V; Rebagliati, I; Zaninovich, A A; Poderoso, J J

    2001-12-01

    Changes in O(2) uptake at different thyroid status have been explained on the basis of the modulation of mitochondrial enzymes and membrane biophysical properties. Regarding the nitric oxide (NO) effects, we tested whether liver mitochondrial nitric oxide synthase (mtNOS) participates in the modulation of O(2) uptake in thyroid disorders. Wistar rats were inoculated with 400 microCi (131)I (hypothyroid group), 20 microg thyroxine (T(4))/100 g body wt administered daily for 2 wk (hyperthyroid group) or vehicle (control). Basal metabolic rate, mitochondrial function, and mtNOS activity were analyzed. Systemic and liver mitochondrial O(2) uptake and cytochrome oxidase activity were lower in hypothyroid rats with respect to controls; mitochondrial parameters were further decreased by L-arginine (-42 and -34%, P activity (260%) were selectively increased in hypothyroidism and reverted by hormone replacement without changes in other nitric oxide isoforms. Moreover, mtNOS activity correlated with serum 3,5,3'-triiodothyronine (T(3)) and O(2) uptake. Increased mtNOS activity was also observed in skeletal muscle mitochondria from hypothyroid rats. Therefore, we suggest that modulation of mtNOS is a substantial part of thyroid effects on mitochondrial O(2) uptake.

  6. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis.

    Science.gov (United States)

    Parhad, Swapnil S; Jaiswal, Deepa; Ray, Krishanu; Mazumdar, Shyamalava

    2016-03-25

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in l-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

    Science.gov (United States)

    Cerqueira, Fernanda M; Laurindo, Francisco R M; Kowaltowski, Alicia J

    2011-03-31

    Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

  8. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

    Directory of Open Access Journals (Sweden)

    Fernanda M Cerqueira

    2011-03-01

    Full Text Available Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR. Since treatment of mice with dinitrophenol (DNP promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

  9. Fluxo do transporte de suínos para abate no Estado de Mato Grosso

    OpenAIRE

    Pereira,Thuanny Lúcia; Corassa,Anderson

    2014-01-01

    Objetivou-se descrever o fluxo de suínos para abate produzidos no Estado de Mato Grosso entre os anos de 2008 e 2012. Foram utilizados dados de 9.426.729 suínos produzidos no Estado de Mato Grosso e transportados para abate de janeiro de 2008 a dezembro de 2012, no qual realizou-se análise descritiva das informações, com frequências de origem e destino; machos e fêmeas em função dos meses e anos e as distâncias percorridas. Observou-se crescimento no número de viagens e de suínos transportado...

  10. Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added $^{18}$F-Labelling Methods

    OpenAIRE

    Drerup, Christian; Ermert, Johannes; Coenen, Heinrich Hubert

    2016-01-01

    Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders. Selective inhibitors of the subtypes iNOS (inducible) or nNOS (neuronal) are of great interest for decoding neurodestructive key factors, and 18F-labelled analogues would allow investigating the NOS-function by molecular imaging with positron emission tomography. Especially, the highly selective nNOS inhibitor 6-((3-((...

  11. Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

    Science.gov (United States)

    Trettin, Arne; Böhmer, Anke; Suchy, Maria-Theresia; Probst, Irmelin; Staerk, Ulrich; Stichtenoth, Dirk O.; Frölich, Jürgen C.

    2014-01-01

    Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromboxane, nitric oxide (NO), and oxidative stress in four male subjects who received a single 3 g oral dose of paracetamol. Thromboxane and prostacyclin synthesis was assessed by measuring their major urinary metabolites 2,3-dinor-thromboxane B2 and 2,3-dinor-6-ketoprostaglandin F1α, respectively. Endothelial NO synthesis was assessed by measuring nitrite in plasma. Urinary 15(S)-8-iso-prostaglanding F2α was measured to assess oxidative stress. Plasma oleic acid oxide (cis-EpOA) was measured as a marker of cytochrome P450 activity. Upon paracetamol administration, prostacyclin synthesis was strongly inhibited, while NO synthesis increased and thromboxane synthesis remained almost unchanged. Paracetamol may shift the COX-dependent vasodilatation/vasoconstriction balance at the cost of vasodilatation. This effect may be antagonized by increasing endothelial NO synthesis. High-dosed paracetamol did not increase oxidative stress. At pharmacologically relevant concentrations, paracetamol did not affect NO synthesis/bioavailability by recombinant human endothelial NOS or inducible NOS in rat hepatocytes. We conclude that paracetamol does not increase oxidative stress in humans. PMID:24799980

  12. Religião e patriotismo: o anticomunismo católico nos Estados Unidos e no Brasil nos anos da Guerra Fria

    Directory of Open Access Journals (Sweden)

    Carla Simone Rodeghero

    2002-01-01

    Full Text Available O artigo analisa e compara o anticomunismo católico no Brasil e nos Estados Unidos no período da Guerra Fria. Depois de situar o campo de estudos constituído no Brasil sobre o tema, discute as relações entre americanismo e anticomunismo, procurando situar o catolicismo norte-americano neste meio. Utiliza-se de uma produção recente sobre cultura da Guerra Fria nos Estados Unidos. Levanta, finalmente, uma série de elementos de comparação sobre a forma que o anticomunismo católico assumiu nos dois países.This article analyses and compares the Catholic anticommunism in the Brazil and in United States during the Cold War years. After showing the recent studies produced in Brazil about the fight against communism, it discusses the relationship between Americanism, anticommunism and Catholicism. This step is based on recent historical research about the Cold War culture in the United States. Finally, it makes comparisons between the forms that anticommunism assumed in each country.

  13. Intoxicação experimental de suínos por fumonisinas

    Directory of Open Access Journals (Sweden)

    Dilkin Paulo

    2004-01-01

    Full Text Available Os efeitos da exposição oral prolongada (28 dias à fumonisina foram estudados em suínos jovens. Os animais foram divididos em três grupos experimentais e alimentados com ração ad libitum contendo: A 0mg de FB1.kg-1 (controle; B 10mg de FB1.kg-1; C 30mg de FB1.kg-1. Os suínos foram observados duas vezes por dia; seus pesos e consumo alimentar foram registrados semanalmente. Entre o 20º e 24º dia de intoxicação, os suínos do tratamentos C apresentaram diminuição do consumo de ração e ganho de peso, sinais característicos de edema pulmonar, razão pela qual um animal foi levado a óbito aos 23 dias de intoxicação. Após 28 dias, os animais foram necropsiados e os órgãos submetidos a análises macroscópica, histopatológica e ao estudo da morfologia e histologia intestinal. Nos suínos que apresentaram sinais clínicos de intoxicação, observaram-se lesões pulmonares, hepáticas e diminuição de altura das vilosidades e profundidade das criptas e hiperplasia glandular em segmentos intestinais. Conclui-se, portanto, que substanciais perdas de produtividade podem ser induzidas em suínos alimentados com ração contaminada com baixos níveis de fumonisinas.

  14. Inducible nitric oxide synthase (iNOS) regulatory region variation in non-human primates.

    Science.gov (United States)

    Roodgar, Morteza; Ross, Cody T; Kenyon, Nicholas J; Marcelino, Gretchen; Smith, David Glenn

    2015-04-01

    Inducible nitric oxide synthase (iNOS) is an enzyme that plays a key role in intracellular immune response against respiratory infections. Since various species of nonhuman primates exhibit different levels of susceptibility to infectious respiratory diseases, and since variation in regulatory regions of genes is thought to play a key role in expression levels of genes, two candidate regulatory regions of iNOS were mapped, sequenced, and compared across five species of nonhuman primates: African green monkeys (Chlorocebus sabaeus), pig-tailed macaques (Macaca nemestrina), cynomolgus macaques (Macaca fascicularis), Indian rhesus macaques (Macaca mulatta), and Chinese rhesus macaques (M. mulatta). In addition, we conducted an in silico analysis of the transcription factor binding sites associated with genetic variation in these two candidate regulatory regions across species. We found that only one of the two candidate regions showed strong evidence of involvement in iNOS regulation. Specifically, we found evidence of 13 conserved binding site candidates linked to iNOS regulation: AP-1, C/EBPB, CREB, GATA-1, GATA-3, NF-AT, NF-AT5, NF-κB, KLF4, Oct-1, PEA3, SMAD3, and TCF11. Additionally, we found evidence of interspecies variation in binding sites for several regulatory elements linked to iNOS (GATA-3, GATA-4, KLF6, SRF, STAT-1, STAT-3, OLF-1 and HIF-1) across species, especially in African green monkeys relative to other species. Given the key role of iNOS in respiratory immune response, the findings of this study might help guide the direction of future studies aimed to uncover the molecular mechanisms underlying the increased susceptibility of African green monkeys to several viral and bacterial respiratory infections. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. A vast amount of various invariant tori in the Nosé-Hoover oscillator.

    Science.gov (United States)

    Wang, Lei; Yang, Xiao-Song

    2015-12-01

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

  16. A vast amount of various invariant tori in the Nosé-Hoover oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lei [School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074 (China); Department of Mathematics and Physics, Hefei University, Hefei 230601 (China); Yang, Xiao-Song, E-mail: yangxs@hust.edu.cn [School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2015-12-15

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of “chaotic region” and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a “chaotic sea” for the Nosé-Hoover oscillator.

  17. A vast amount of various invariant tori in the Nosé-Hoover oscillator

    Science.gov (United States)

    Wang, Lei; Yang, Xiao-Song

    2015-12-01

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

  18. Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction.

    Directory of Open Access Journals (Sweden)

    Simone Gorressen

    Full Text Available Nitric oxide (NO is constitutively produced and released from the endothelium and several blood cell types by the isoform 3 of the NO synthase (NOS3. We have shown that NO protects against myocardial ischemia/reperfusion (I/R injury and that depletion of circulating NOS3 increases within 24 h of ischemia/reperfusion the size of myocardial infarction (MI in chimeric mice devoid of circulating NOS3. In the current study we hypothesized that circulating NOS3 also affects remodeling of the left ventricle following reperfused MI.To analyze the role of circulating NOS3 we transplanted bone marrow of NOS3-/- and wild type (WT mice into WT mice, producing chimerae expressing NOS3 only in vascular endothelium (BC-/EC+ or in both, blood cells and vascular endothelium (BC+/EC+. Both groups underwent 60 min of coronary occlusion in a closed-chest model of reperfused MI. During the 3 weeks post MI, structural and functional LV remodeling was serially assessed (24 h, 4 d, 1 w, 2 w and 3 w by echocardiography. At 72 hours post MI, gene expression of several extracellular matrix (ECM modifying molecules was determined by quantitative RT-PCR analysis. At 3 weeks post MI, hemodynamics were obtained by pressure catheter, scar size and collagen content were quantified post mortem by Gomori's One-step trichrome staining.Three weeks post MI, LV end-systolic (53.2±5.9 μl; ***p≤0.001; n = 5 and end-diastolic volumes (82.7±5.6 μl; *p<0.05; n = 5 were significantly increased in BC-/EC+, along with decreased LV developed pressure (67.5±1.8 mm Hg; n = 18; ***p≤0.001 and increased scar size/left ventricle (19.5±1.5%; n = 13; **p≤0.01 compared to BC+/EC+ (ESV: 35.6±2.2 μl; EDV: 69.1±2.6 μl n = 8; LVDP: 83.2±3.2 mm Hg; n = 24; scar size/LV13.8±0.7%; n = 16. Myocardial scar of BC-/EC+ was characterized by increased total collagen content (20.2±0.8%; n = 13; ***p≤0.001 compared to BC+/EC+ (15.9±0.5; n = 16, and increased collagen type I and III subtypes

  19. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain.

    Science.gov (United States)

    Cattano, D; Valleggi, S; Abramo, A; Forfori, F; Maze, M; Giunta, F

    2010-06-01

    Animal studies suggest that neuronal cell death often results from anesthetic administration during synaptogenesis. Volatile anesthetics are strongly involved in triggering neuronal apoptosis, whereas other inhalational agents (xenon) demonstrate protective effects. Nitrous oxide (N2O) has modest pro-apoptotic effects on its own and potent, synergistic toxic effects when combined with volatile agents. Recent findings suggest that, during periods of rapid brain development, the enhanced neurodegeneration triggered by anesthetic drugs may be caused by a compensatory increase in intracellular free calcium, a potent activator of neuronal nitric oxide synthase (nNOS). Anesthesia-induced neuro-apoptosis is also activated via the intrinsic and the extrinsic apoptotic pathways because both pathways involve p53, a key regulatory gene. The molecular events related to neuronal cell apoptosis are not completely understood. To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels. The study used 2 groups of postnatal day seven Sprague/Dawley rats (N=6 each) that were exposed for 120 minutes to air (75% N2, 25% O2) or N2O (75% N2O, 25% O2; this N2O concentration is commonly used to induce anesthesia and has been demonstrated to trigger neurodegeneration in postnatal day seven rats). Total RNA was isolated from each brain and expression analyses on iNOS and nNOS transcripts were performed using relative Real-Time C-reactive protein PCR (using G3PDH as a housekeeping gene). A semi-quantitative RT-PCR analysis was performed on the p53 transcript (using Ciclophylin A as a housekeeping gene). Statistical analysis (REST 2005) revealed a significant, 11-fold up-regulation (P=0.026) of the nNOS transcript but no significant changes in iNOS transcription. The p53 mRNA was up-regulated almost 2-fold (P=0.0002; Student's t-Test; GraphPad Prism 4.00) in N2O-treated samples relative to

  20. O papel de imunoglobulinas na nefropatia da leptospirose em suínos

    Directory of Open Access Journals (Sweden)

    Larissa M.F. Gonçalves

    2014-06-01

    Full Text Available A leptospirose é uma antropozoonose endêmica em todo o mundo, que afeta o homem e várias espécies de animais domésticos e silvestres. No início da infecção há produção de IgM para o controle da infecção e após alguns dias, IgG são produzidas e provocam lise das leptospiras circulantes. Objetivou-se neste estudo identificar depósitos de antígeno de leptospiras e imunoglobulinas no tecido renal, para avaliar o papel de imunoglobulinas na patogênese da nefropatia da leptospirose em suínos. Foram colhidas 139 amostras de sangue e rim de suínos das cidades de Teresina/PI e Timon/MA, que foram avaliadas pela SAM, imunoistoquímica e PCR. Nefrite intersticial, fibrose, vasculite, tumefação do tufo glomerular e hipercelularidade difusa foram as principais alterações histopatológicas encontradas. A imunoistoquímica detectou antígeno de leptospira em 60 suínos. Depósitos de IgG, IgM e IgA foram observados no endotélio de capilares glomerulares, dos capilares intertubulares e na cápsula de Bowman, com marcação focal, difusa, global e segmentar. A deposição de IgM e IgA foi significantemente maior nos suínos infectados. Estranhamente depósitos de IgG foi significantemente maior nos suínos não infectados, onde não havia presença de antígeno de leptospiras e nem lesão túbulo-intersticial. Concluímos que antígeno de leptospiras no rim de suínos está relacionado a depósitos de IgM e IgA mas não a depósitos de IgG.

  1. ICoNOs MM: The IT-enabled Collaborative Networked Organizations Maturity Model

    NARCIS (Netherlands)

    Santana Tapia, R.G.

    2009-01-01

    The focus of this paper is to introduce a comprehensive model for assessing and improving maturity of business-IT alignment (B-ITa) in collaborative networked organizations (CNOs): the ICoNOs MM. This two dimensional maturity model (MM) addresses five levels of maturity as well as four domains to

  2. Resting Tension Affects eNOS Activity in a Calcium-Dependent Way in Airways

    Directory of Open Access Journals (Sweden)

    Paschalis-Adam Molyvdas

    2007-03-01

    Full Text Available The alteration of resting tension (RT from 0.5 g to 2.5 g increased significantly airway smooth muscle contractions induced by acetylcholine (ACh in rabbit trachea. The decrease in extracellular calcium concentration [Ca2+]o from 2 mM to 0.2 mM reduced ACh-induced contractions only at 2.5 g RT with no effect at 0.5 g RT. The nonselective inhibitor of nitric oxide synthase (NOS, NG-nitro-L-arginine methyl ester (L-NAME increased ACh-induced contractions at 2.5 g RT. The inhibitor of inducible NOS, S-methylsothiourea or neuronal NOS, 7-nitroindazole had no effect. At 2.5 g RT, the reduction of [Ca2+]o from 2 mM to 0.2 mM abolished the effect of L-NAME on ACh-induced contractions. The NO precursor L-arginine or the tyrosine kinase inhibitors erbstatin A and genistein had no effect on ACh-induced contractions obtained at 2.5 g RT. Our results suggest that in airways, RT affects ACh-induced contractions by modulating the activity of epithelial NOS in a calcium-dependent, tyrosine-phosphorylation-independent way.

  3. Induction of expression of iNOS by N-nitrosodimethylamine (NDMA) in human leukocytes.

    Science.gov (United States)

    Ratajczak-Wrona, Wioletta; Jablonska, Ewa; Jablonski, Jakub; Marcinczyk, Magdalena

    2009-01-01

    The aim of this study was to assess the influence of N-nitrosodimethylamine (NDMA) on expression of inducible nitric oxide synthase (iNOS), as well as production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) by human neutrophils (PMN) and peripheral blood mononuclear cells (PBMC), and the participation of the p38 MAPK kinase in this process. Furthermore, the ability of neutrophils to release superoxide anion was determined. The influence of N-nitrosodimethylamine on iNOS expression was determined in isolated PMN and PBMC cells from peripheral blood of healthy individuals. The mononuclear cells showed higher sensitivity to NDMA. Moreover, cytotoxic effect of NDMA can be influenced in some way by the impact of this xenobiotic on nitric oxide and superoxide anion release from human leukocytes. Furthermore, increased generation of these radicals by human leukocytes suggest that neutrophils and mononuclear cells that are exposed to NDMA activity can play a key role in endogenous NDMA generation. However the relationship between iNOS expression and phospho-p38 MAPK in neutrophils and mononuclear cells shows that p38 MAPK pathway participates in induction of iNOS expression in the presence of NDMA.

  4. Inhibition of iNOS and DNA Oxidation by Methanol Extract of ...

    African Journals Online (AJOL)

    Purpose: To investigate the antioxidant properties of the methanol extract of S. tenuifolia as well as its effect on inducible nitric oxide synthase (iNOS) and cycleooxygenase-2 (COX-2) expression in lipopolysaccharides (LPS)-induced cell damage in macrophage cells. Methods: The antioxidant activities of the plant extract ...

  5. nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.

    Science.gov (United States)

    Itzhak, Y; Martin, J L; Ail, S F

    2000-09-11

    Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) inhibitors on METH-induced hyperthermia and striatal dopaminergic neurotoxicity. Administration of METH (5 mg/kg; q. 3 h x 3) to Swiss Webster mice produced marked hyperthermia and 50-60% depletion of striatal dopaminergic markers 72 h after METH administration. Pretreatment with the nNOS inhibitors S-methylthiocitrulline (SMTC; 10 mg/kg) or 3-bromo-7-nitroindazole (3-Br-7-NI; 20 mg/kg) before each METH injection did not affect the persistent hyperthermia produced by METH, but afforded protection against the depletion of dopaminergic markers. A low dose (25 mg/kg) of the nNOS inhibitor 7-nitroindazole (7-NI) did not affect METH-induced hyperthermia, but a high dose (50 mg/kg) produced significant hypothermia. These findings indicate that low dose of selective nNOS inhibitors protect against METH-induced neurotoxicity with no effect on body temperature and support the hypothesis that nitric oxide (NO) and peroxynitrite have a major role in METH-induced dopaminergic neurotoxicity.

  6. From Orthodoxy to Plurality in the Nature of Science (NOS) and Science Education: A Metacommentary

    Science.gov (United States)

    Bazzul, Jesse

    2017-01-01

    This article provides a metacommentary on the special issue on nature of science (NOS). The issue is composed of senior scholars discussing Hodson and Wong's (2017, this issue) critique of the consensus view of nature of science, which on a basic level states that there are agreed-upon aspects of science that can be taught in K-12 schools. Each…

  7. Role of iNOS in Bystander Signaling Between Macrophages and Lymphoma Cells

    International Nuclear Information System (INIS)

    Ghosh, Somnath; Maurya, Dharmendra Kumar; Krishna, Malini

    2008-01-01

    Purpose: The present report describes the bystander effects of radiation between similar and dissimilar cells and the role of iNOS in such communication. Materials and Methods: EL-4 and RAW 264.7 cells were exposed to 5 Gy γ-irradiation. The medium from irradiated cells was transferred to unirradiated cells. Results: Irradiated EL-4 cells as well as those cultured in the presence of medium from γ-irradiated EL-4 cells showed an upregulation of NF-κB, iNOS, p53, and p21/waf1 genes. The directly irradiated and the bystander EL-4 cells showed an increase in DNA damage, apoptosis, and NO production. Bystander signaling was also found to exist between RAW 264.7 (macrophage) and EL-4 (lymphoma) cells. Unstimulated or irradiated RAW 264.7 cells did not induce bystander effect in unirradiated EL-4 cells, but LPS stimulated and irradiated RAW 264.7 cells induced an upregulation of NF-κB and iNOS genes and increased the DNA damage in bystander EL-4 cells. Treatment of EL-4 or RAW 264.7 cells with L-NAME significantly reduced the induction of gene expression and DNA damage in the bystander EL-4 cells, whereas treatment with cPTIO only partially reduced the induction of gene expression and DNA damage in the bystander EL-4 cells. Conclusions: It was concluded that active iNOS in the irradiated cells was essential for bystander response

  8. Decreased NOS1 expression in the anterior cingulate cortex in depression

    NARCIS (Netherlands)

    Gao, Shang-Feng; Qi, Xin-Rui; Zhao, Juan; Balesar, Rawien; Bao, Ai-Min; Swaab, Dick F.

    2013-01-01

    Decreased function of the anterior cingulate cortex (ACC) is crucially involved in the pathogenesis of depression. A key role of nitric oxide (NO) has also been proposed. We aimed to determine the NO content in the cerebrospinal fluid (CSF) and the expression of NO synthase (NOS) isoforms, that is,

  9. Animal Certifié Conforme: Déchiffrer nos Relations avec le Vivant

    Directory of Open Access Journals (Sweden)

    Daniel W. Gade

    2014-01-01

    Full Text Available Review of Animal Certifié Conforme: Déchiffrer nos Relations avec le Vivant. Bernadette Lizet and Jacqueline Milliet, eds. 2012. Dunod/Muséum National d’Histoire Naturelle, Paris. Pp 256. €22 (paperback. ISBN 9782100582853.

  10. Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

    Science.gov (United States)

    Sarginson, Jane E; Deakin, JF William; Anderson, Ian M; Downey, Darragh; Thomas, Emma; Elliott, Rebecca; Juhasz, Gabriella

    2014-01-01

    There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression. PMID:24917196

  11. Enhancing Students' NOS Views and Science Knowledge Using Facebook-Based Scientific News

    Science.gov (United States)

    Huang, Hsi-Yu; Wu, Hui-Ling; She, Hsiao-Ching; Lin, Yu-Ren

    2014-01-01

    This study investigated how the different discussion approaches in Facebook influenced students' scientific knowledge acquisition and the nature of science (NOS) views. Two eighth- and two ninth-grade classes in a Taiwanese junior high school participated in the study. In two of the classes students engaged in synchronous discussion, and in the…

  12. Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

    Directory of Open Access Journals (Sweden)

    Sara N. Koenig

    2015-03-01

    Full Text Available Thoracic aortic aneurysms (TAA are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV and aortopathy in humans. The aim of this study was to determine if haploinsufficiency of Notch1 contributes to aortopathy using Notch1+/−; Nos3−/− mice. Echocardiographic analysis of Notch1+/−; Nos3−/− mice reveals effacement of the sinotubular junction and a trend toward dilation of the aortic sinus. Furthermore, examination of the proximal aorta of Notch1+/−; Nos3−/− mice reveals elastic fiber degradation, a trend toward increased matrix metalloproteinase 2 expression, and increased smooth muscle cell apoptosis, features characteristic of aneurysmal disease. Although at a lower penetrance, we also found features consistent with aortopathic changes in Notch1 heterozygote mice and in Nos3-null mice. Our findings implicate a novel role for Notch1 in aortopathy of the proximal aorta.

  13. Association between nucleotide mutation of eNOS gene and serum ...

    African Journals Online (AJOL)

    Galaxy

    2013-05-15

    May 15, 2013 ... spasm among Japanese (Nakayama et al., 1999; Casas et al., 2006). It is believed that these mutations might result in altered NO metabolism and impaired .... ship between T-786C mutation of eNOS gene and CAD specifically in the Iranian population. To our knowledge, this polymorphism has never been ...

  14. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.

    NARCIS (Netherlands)

    Ayub, H.; Khan, M.I.; Micheal, S.; Akhtar, F.; Ajmal, M.; Shafique, S.; Ali, S.H.; Hollander, A.I. den; Ahmed, A.; Qamar, R.

    2010-01-01

    PURPOSE: To investigate the involvement of stress-regulating genes, endothelial nitric oxide synthase (eNOS) and heat shock protein 70 (HSP70) with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG). METHODS: POAG and PCAG patients recruited from different areas of Pakistan

  15. Morus alba extract modulates blood pressure homeostasis through eNOS signaling.

    Science.gov (United States)

    Carrizzo, Albino; Ambrosio, Mariateresa; Damato, Antonio; Madonna, Michele; Storto, Marianna; Capocci, Luca; Campiglia, Pietro; Sommella, Eduardo; Trimarco, Valentina; Rozza, Francesco; Izzo, Raffaele; Puca, Annibale A; Vecchione, Carmine

    2016-10-01

    Morus alba is a promising phytomedicine cultivated in oriental countries that is extensively used to prevent and treat various cardiovascular problems. To date, despite its beneficial effects, the molecular mechanisms involved remain unclear. Thus, we investigate the vascular and haemodynamic effects of Morus alba extract in an experimental model focusing our attention on the molecular mechanisms involved. Through vascular reactivity studies, we demonstrate that Morus alba extract evokes endothelial vasorelaxation through a nitric oxide-dependent pathway. Our molecular analysis highlights an increase in endothelial nitric oxide synthase (eNOS) phosphorylation. In vivo administration of Morus alba extract reduces blood pressure levels exclusively in wild-type mice, whereas it fails to evoke any haemodynamic effects in eNOS-deficient mice. Molecular analyses revealed that its beneficial action on vasculature is mediated by the activation of two important proteins that act as stress sensors and chaperones: PERK and heat shock protein 90. Finally, Morus alba extract exerts antihypertensive action in an experimental model of arterial hypertension. Through its action on eNOS signaling, Morus alba extract could act as a food supplement for the regulation of cardiovascular system, mainly in clinical conditions characterized by eNOS dysfunction, such as arterial hypertension. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Association of the NOS3 intron-4 VNTR polymorphism with aneurysmal subarachnoid hemorrhage

    DEFF Research Database (Denmark)

    Staalsø, Jonatan Myrup; Edsen, Troels; Kotinis, Alexandros

    2014-01-01

    OBJECT: The nitric oxide system has been linked to the pathogenesis of aneurysmal subarachnoid hemorrhage (SAH). The authors performed a case-control study to investigate the association between SAH and common genetic variants within the endothelial nitric oxide synthase gene (NOS3). METHODS: Thr...

  17. Neuronal nitric oxide synthase (NOS1) polymorphisms interact with financial hardship to affect depression risk.

    Science.gov (United States)

    Sarginson, Jane E; Deakin, J F William; Anderson, Ian M; Downey, Darragh; Thomas, Emma; Elliott, Rebecca; Juhasz, Gabriella

    2014-11-01

    There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression.

  18. Psychomteric Validation of the Health of Nation Outcome Scales (HoNOS) in Traumatized Refugees

    DEFF Research Database (Denmark)

    Palic, Sabina; Elklit, Ask; Makransky, Guido

    -treatment data from 448 consecutive patients at three Danish psychiatric clinics for refugees. A10-item HoNOS version (physical problems and daily function items excluded) of pre-treatment data fit the Rasch model well. A cross validation showed excellent fit of the post-treatment data to the 10-item model...

  19. 77 FR 12010 - Marine Mammals; File Nos. 1076-1789 and 14502

    Science.gov (United States)

    2012-02-28

    ... NMFS to study and document the health and biology of wild marine mammals as well as those marine... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB040 Marine Mammals; File Nos. 1076-1789 and 14502 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic...

  20. Using Video Modeling to Teach Children with PDD-NOS to Respond to Facial Expressions

    Science.gov (United States)

    Axe, Judah B.; Evans, Christine J.

    2012-01-01

    Children with autism spectrum disorders often exhibit delays in responding to facial expressions, and few studies have examined teaching responding to subtle facial expressions to this population. We used video modeling to train 3 participants with PDD-NOS (age 5) to respond to eight facial expressions: approval, bored, calming, disapproval,…

  1. Sociodemographic, neuropsychiatric and cognitive characteristics of pathological gambling and impulse control disorders NOS in Parkinson's disease.

    Science.gov (United States)

    Pontieri, Francesco E; Assogna, Francesca; Pellicano, Clelia; Cacciari, Claudia; Pannunzi, Sara; Morrone, Annalucia; Danese, Emanuela; Caltagirone, Carlo; Spalletta, Gianfranco

    2015-01-01

    Despite of previous evidence supporting the association between impulse control disorder (ICD) and several demographic, clinical and therapeutic features in Parkinson's disease (PD), the relationships between pathological gambling (PG) or other variants of ICD (ICD-NOS) and specific neuropsychiatric or cognitive domains are not entirely defined. In this study, 155 PD patients without dementia or cognitive impairment underwent: i. the ICD diagnoses, using the Questionnaire for Impulsive-Compulsive Disorders, ii. the mood and anxiety disorders diagnoses, according to the DSM-IV-TR criteria, and iii. a comprehensive battery for measuring severity of psychopathology and neuropsychology domains. Patients were divided in those with pathological gambling (PG), ICDs not otherwise specified (ICD-NOS), or the lack of ICD (No-ICD). There was a progression in age and age at onset from the younger PG subjects throughout ICD-NOS to No-ICD. PG and ICD-NOS subjects had longer disease duration and were taking significantly higher dosages of antiparkinsonian drugs than No-ICD ones. PG subjects had significantly higher severity of depressive and anxious symptoms with respect to the other 2 groups. Both PG and ICD-NOS subjects suffer from increased severity of psychotic symptoms than No-ICD ones. The 3 groups did not differ in any cognitive measure. Our results support the concept that the different sociodemographic and neuropsychiatric profiles of PD patients are associated with different ICDs. Moreover, we clearly demonstrate the lack of relationship between ICD and cognitive performances in undemented PD patients. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  2. Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries.

    Science.gov (United States)

    Laughlin, M Harold; Welshons, Wade V; Sturek, Michael; Rush, James W E; Turk, James R; Taylor, Julia A; Judy, Barbara M; Henderson, Kyle K; Ganjam, V K

    2003-07-01

    Our purpose was to determine the effects of gender and exercise training on endothelial nitric oxide synthase (eNOS) and superoxide dismutase (SOD) protein content of porcine skeletal muscle arteries and to evaluate the role of 17beta-estradiol (E2) in these effects. We measured eNOS and SOD content with immunoblots and immunohistochemistry in femoral and brachial arteries of trained and sedentary male and female pigs and measured estrogen receptor (ER) mRNA and alpha-ER and beta-ER protein in aortas of male and female pigs. Results indicate that female arteries contain more eNOS than male arteries and that exercise training increases eNOS content independent of gender. Male and female pigs expressed similar levels of alpha-ER mRNA and protein and similar amounts beta-ER protein in their arteries. E2 concentrations as measured by RIA were 180 +/- 34 pg/ml in male sera and approximately 5 pg/ml in female sera, and neither was changed by training. However, bioassay indicated that biologically active estrogen equivalent to only 35 +/- 5 pg/ml was present in male sera. E2 in female pigs, whether measured by RIA or bioassay, was approximately 24 pg/ml at peak estrous and 2 pg/ml on day 5 diestrus. The free fraction of E2 in sera did not explain the low measurements, relative to RIA, of E2. We conclude that 1). gender has significant influence on eNOS and SOD content of porcine skeletal muscle arteries; 2). the effects of gender and exercise training vary among arteries of different anatomic origin; 3). male sera contains compounds that cause RIA to overestimate circulating estrogenic activity; and 4). relative to human men, the male pig is not biologically estrogenized by high levels of E2 reported by RIA, whereas in female pigs E2 levels are lower than in the blood of human women.

  3. Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock.

    Science.gov (United States)

    Su, Fuhong; Huang, Hongchuan; Akieda, Kazuki; Occhipinti, Giovanna; Donadello, Katia; Piagnerelli, Michael; De Backer, Daniel; Vincent, Jean-Louis

    2010-09-01

    Inhibition of NOS is not beneficial in septic shock; selective inhibition of the inducible form (iNOS) may represent a better option. We compared the effects of the selective iNOS inhibitor BYK191023 with those of norepinephrine (NE) in a sheep model of septic shock. Twenty-four anesthetized, mechanically ventilated ewes received 1.5 g/kg body weight of feces into the abdominal cavity to induce sepsis. Animals were randomized into three groups (each n = 8): NE-only, BYK-only, and NE + BYK. The sublingual microcirculation was evaluated with sidestream dark-field videomicroscopy. MAP was higher in the NE + BYK group than in the other groups, but there were no significant differences in cardiac index or systemic vascular resistance. Mean pulmonary arterial pressure was lower in BYK-treated animals than in the NE-only group. PaO2/FiO2 was higher and lactate concentration lower in the BYK groups than in the NE-only group. Mesenteric blood flow was higher in BYK groups than in the NE-only group. Renal blood flow was higher in the NE + BYK group than in the other groups. Functional capillary density and proportion of perfused vessels were higher in the BYK groups than in the NE-only group 18 h after induction of peritonitis. Survival times were similar in the three groups. In this model of peritonitis, selective iNOS inhibition had more beneficial effects than NE on pulmonary artery pressures, gas exchange, mesenteric blood flow, microcirculation, and lactate concentration. Combination of this selective iNOS inhibitor with NE allowed a higher arterial pressure and renal blood flow to be maintained.

  4. Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin

    NARCIS (Netherlands)

    Lechner, Matthias; Lirk, Philipp; Rieder, Josef

    2005-01-01

    Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide (NO) from the amino acid l-arginine. iNOS-derived NO plays an important role in numerous physiological (e.g. blood pressure regulation, wound repair and host defence mechanisms) and pathophysiological

  5. Nitric oxide synthase (NOS) in the trigeminal vascular system and other brain structures related to pain in rats

    DEFF Research Database (Denmark)

    Ramachandran, Roshni; Ploug, Kenneth Beri; Hay-Schmidt, Anders

    2010-01-01

    to measure the respective levels of mRNA and protein for nNOS and eNOS in peripheral and central tissues involved in migraine pain: dura mater, pial arteries, trigeminal ganglion (TG) trigeminal nucleus caudalis (TNC), periaqueductal grey (PAG), thalamus, hypothalamus, cortex, pituitary gland, hippocampus...... and cerebellum. iNOS was excluded from the present study because it was not induced. In the trigeminal vascular system we found the highest expression of nNOS mRNA in pial arteries. However, protein expression of nNOS was maximum in TNC. Among other brain structures, nNOS mRNA and protein expression...... was remarkably higher in the cerebellum than in any other tissues. Regarding eNOS in the trigeminovascular system, the highest mRNA expression was found in pial arteries. In the other brain structures, eNOS mRNA expression was similar but with lowest mRNA concentration in the pituitary gland and the highest...

  6. ONE PROBABLE MECHANISM OF THE LEARNING-MEMORY DAMAGE BY LEAD: THE CHANGES OF NOS IN HIPPOCAMPUS

    Institute of Scientific and Technical Information of China (English)

    王静; 赵义; 杨章民; 张进; 李积胜; 司履生; 王一理

    2003-01-01

    Objective To study the effects of lead on the activity and expression of nitric oxide synthase (NOS) and relationship between the effects of lead on learning-memory and changes of NOS in subfields of hippocampus. Methods Y-maze test was used to study the effects of lead on ability of learning-memory; NADPH-d histochemistry and immunohistochemistry methods were used to investigate the changes of NOS in subfields of hippocampus. Results Compared with the control group, the ability of learning- memory in lead-exposed rats was significantly decreased (P<0.05); the number of NOS positive neurons in CA1 region and dentate gyrus of lead-exposed rats was significantly decreased(P<0.05), but no marked changes in CA3 region; the number of nNOS positive neurons in CA1 of lead-exposed rats was also significantly decreased(P<0.05), but no obvious changes in CA3. Conclusion Lead could damage the ability of learning-memory in rats. Lead could decrease the activity and expression of NOS in hippocampus and had different effects on NOS in different subfields of hippocampus. The changes of NOS in hippocampus induced by lead may be the mechanism of the learning-memory damage by lead.

  7. 76 FR 1469 - Calvert Cliffs Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2011-01-10

    ... Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2 Environmental Assessment... Plant, LLC, the licensee, for operation of the Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2... Impact Statement for License Renewal of Nuclear Plants, Calvert Cliffs Nuclear Power Plant (NUREG-1437...

  8. 75 FR 66802 - Calvert Cliffs Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2010-10-29

    ... Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2; Notice of Withdrawal of...) has granted the request of Calvert Cliffs Nuclear Power Plant, LLC, the licensee, to withdraw its... for the Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2, located in Calvert County, MD. The...

  9. Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

    NARCIS (Netherlands)

    Jamshidi, Yalda; Nolte, Ilja M.; Dalageorgou, Chrysoula; Zheng, Dongling; Johnson, Toby; Bastiaenen, Rachel; Ruddy, Suzanne; Talbott, Daniel; Norris, Kris J.; Snieder, Harold; George, Alfred L.; Marshall, Vanessa; Shakir, Saad; Kannankeril, Prince J.; Munroe, Patricia B.; Camm, A. John; Jeffery, Steve; Roden, Dan M.; Behr, Elijah R.

    2012-01-01

    Objectives This study sought to determine whether variations in NOS1AP affect drug-induced long QT syndrome (LQTS). Background Use of antiarrhythmic drugs is limited by the high incidence of serious adverse events including QT prolongation and torsades de pointes. NOS1AP gene variants play a role in

  10. Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice

    International Nuclear Information System (INIS)

    Bai Ni; Kido, Takashi; Kavanagh, Terrance J.; Kaufman, Joel D.; Rosenfeld, Michael E.; Breemen, Cornelis van; Eeden, Stephan F. van

    2011-01-01

    Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction, progression of atherosclerosis and ultimately cardiovascular morbidity and mortality. Methods: ApoE knockout mice (30-week) were exposed to DE (at 200 μg/m 3 of particulate matter) or filtered-air (control) for 7 weeks (6 h/day, 5 days/week). iNOS expression in the blood vessels and heart was evaluated by immunohistochemistry and western blotting analysis. To examine iNOS activity, thoracic aortae were mounted in a wire myograph, and vasoconstriction stimulated by phenylephrine (PE) was measured with and without the presence of the specific inhibitor for iNOS (1400 W). NF-κB (p65) activity was examined by ELISA. The mRNA expression of iNOS and NF-κB (p65) was determined by real-time PCR. Results: DE exposure significantly enhanced iNOS expression in the thoracic aorta (4-fold) and heart (1.5 fold). DE exposure significantly attenuated PE-stimulated vasoconstriction by ∼ 20%, which was partly reversed by 1400 W. The mRNA expression of iNOS and NF-κB was significantly augmented after DE exposure. NF-κB activity was enhanced 2-fold after DE inhalation, and the augmented NF-κB activity was positively correlated with iNOS expression (R 2 = 0.5998). Conclusions: We show that exposure to DE increases iNOS expression and activity possibly via NF-κB-mediated pathway. We suspect that DE exposure-caused up-regulation of iNOS contributes to vascular dysfunction and atherogenesis, which could ultimately lead to urban air pollution-associated cardiovascular morbidity and mortality. - Highlights: → Exposed ApoE knockout mice (30-week) to diesel exhaust (DE) for 7 weeks. → Examine iNOS expression and activity in the blood vessels and heart. → DE exposure

  11. Changes and significance of TNF - α, NOS activity and NO in the plasma of patients with chronic congestive heart failure

    International Nuclear Information System (INIS)

    Zhou Yafeng; Cheng Xujie; Liu Zhihua

    2003-01-01

    Objective: To study changes and interrelations of TNF - α, NOS activity and NO in the plasma of patients with chronic congestive heart failure (CHF). Methods: The blood samples were taken from eighty patients and twenty healthy subjects. Plasma TNF - α was measured by RIA. Plasma NOS activity and NO were assessed with colorimetric analysis. Results: The level of plasma TNF - α, NOS activity and NO were significantly higher in CHF patients than that in healthy subjects and were increased with the severity of heart failure. The levels of TNF - α, NOS activity and NO showed significant relation with each other and all of them were closely related to the ejection fraction. Conclusion: TNF - α, NOS activity and NO increase greatly in patients of CHF and they maybe play an important roles in the progress of CHF. They can be used as markers for the severity and prognosis of heart failure

  12. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    International Nuclear Information System (INIS)

    Xu, Qin; Zhu, Zhiwei; Xu, Jialu; Gu, Weizhong; Zhao, Zhengyan

    2012-01-01

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS

  13. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Qin; Zhu, Zhiwei; Xu, Jialu [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Gu, Weizhong [Department of Pathology, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Zhao, Zhengyan [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China)

    2012-10-05

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  14. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Directory of Open Access Journals (Sweden)

    Qin Xu

    2012-12-01

    Full Text Available Nitric oxide (NO, synthesized as needed by NO synthase (NOS, is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS. The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS and male wild-type mice (WT at postnatal day 7 (P7, P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7 and nNOS protein was estimated by Western blot (N = 3 and immunohistochemistry (N = 1. In the PCR assessment, primers 5’-GTGGCCATCGTGTCCTACCATAC-3’ and 5’-GTTTCGAGGCAGGTGGAAGCTA-3’ were used for the detection of nNOS and primers 5’-CCGTTTCTCCTGGCTCAGTTTA-3’ and 5’-CCCCAATACCACATCATCCAT-3’ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05. Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05. These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  15. A Teoria Fundamentada nos Dados nos estudos de Pós-Graduação Stricto Sensu da Enfermagem brasileira

    Directory of Open Access Journals (Sweden)

    Marcelle Miranda da Silva

    2011-12-01

    Full Text Available Estudo documental e quantitativo, que objetivou identificar as teses e dissertações defendidas nos Programas de Pós- Graduação em Enfermagem do Brasil que utilizaram o referencial metodológico da Teoria Fundamentada nos Dados (TFD e analisar os aspectos epistemológicos destacados. Os dados foram coletados no Banco de Teses da CAPES, no recorte temporal entre 1996 a 2010. Foram levantados 99 resumos. Realizou-se a leitura analítica dos mesmos para constituição do tema ou problema da pesquisa e do enquadramento teórico. O maior número de produção foi em 2005, na soma dos dois níveis acadêmicos, e 54% das defesas foram sediadas na USP. As áreas temáticas mais expressivas foram: Saúde da Criança/Adolescente; Gestão em Saúde/Enfermagem; Saúde Coletiva e Saúde da Mulher. O principal referencial teórico utilizado foi o Interacionismo Simbólico. A TFD compreende uma metodologia que pode ser empregada na enfermagem, capaz de contribuir no desenvolvimento de novas investigações para o seu aprimoramento contínuo.

  16. β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway.

    Science.gov (United States)

    Pereira, Laëtitia; Bare, Dan J; Galice, Samuel; Shannon, Thomas R; Bers, Donald M

    2017-07-01

    Cardiac β-adrenergic receptors (β-AR) and Ca 2+ -Calmodulin dependent protein kinase (CaMKII) regulate both physiological and pathophysiological Ca 2+ signaling. Elevated diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) contributes to contractile dysfunction in heart failure and to arrhythmogenesis. β-AR activation is known to increase SR Ca 2+ leak via CaMKII-dependent phosphorylation of the ryanodine receptor. Two independent and reportedly parallel pathways have been implicated in this β-AR-CaMKII cascade, one involving exchange protein directly activated by cAMP (Epac2) and another involving nitric oxide synthase 1 (NOS1). Here we tested whether Epac and NOS function in a single series pathway to increase β-AR induced and CaMKII-dependent SR Ca 2+ leak. Leak was measured as both Ca 2+ spark frequency and tetracaine-induced shifts in SR Ca 2+ , in mouse and rabbit ventricular myocytes. Direct Epac activation by 8-CPT (8-(4-chlorophenylthio)-2'-O-methyl-cAMP) mimicked β-AR-induced SR Ca 2+ leak, and both were blocked by NOS inhibition. The same was true for myocyte CaMKII activation (assessed via a FRET-based reporter) and ryanodine receptor phosphorylation. Inhibitor and phosphorylation studies also implicated phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) downstream of Epac and above NOS activation in this pathway. We conclude that these two independently characterized parallel pathways function mainly via a single series arrangement (β-AR-cAMP-Epac-PI3K-Akt-NOS1-CaMKII) to mediate increased SR Ca 2+ leak. Thus, for β-AR activation the cAMP-PKA branch effects inotropy and lusitropy (by effects on Ca 2+ current and SR Ca 2+ -ATPase), this cAMP-Epac-NOS pathway increases pathological diastolic SR Ca 2+ leak. This pathway distinction may allow novel SR Ca 2+ leak therapeutic targeting in treatment of arrhythmias in heart failure that spare the inotropic and lusitropic effects of the PKA branch. Copyright © 2017 Elsevier Ltd. All

  17. A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women.

    Science.gov (United States)

    Shaik, A P; Sultana, A; Bammidi, V K; Sampathirao, K; Jamil, K

    2011-10-01

    A meta-analyses of endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) gene polymorphisms in pre-eclampsia was performed. We shortlisted 33 studies (17 for ACE; 16 for eNOS gene polymorphisms), of which 29 articles (16 for ACE and 15 for eNOS) were analysed. Overall, 1,620 cases with pre-eclampsia and 2,158 controls were analysed for intron 16 insertion-deletion polymorphism in ACE gene. A total of 1,610 subjects with pre-eclampsia and 2,875 controls were analysed for the Glu298Asp in eNOS gene. Overall, the random-effects odds ratio (OR) with Glu298Asp in eNOS gene was 0.958 (95% confidence intervals, CI 0.747-1.228, p > 0.05), and for the insertion-deletion/ACE polymorphism was 0.987 (95% CI 0.698-1.395, p > 0.05). Significant heterogeneity was observed in the studies that evaluated polymorphisms in ACE (Q value = 55.6; I(2) = 73; p value = 0.000); and eNOS (Q value = 37.2; I(2) = 62.4; p value = 0.001) polymorphisms. No significant risk of pre-eclampsia was observed in both eNOS and ACE genes with these polymorphisms.

  18. Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasi.

    Science.gov (United States)

    dos Santos, Fernando Rocha; Vieira, Paula Melo Abreu; Correa-Oliveira, Rodrigo; Giunchetti, Rodolfo Cordeiro; Carneiro, Claudia Martins; Reis, Alexandre Barbosa; Malaquias, Luiz Cosme Cotta

    2011-06-01

    Nitric oxide (NO), the product of the nitric oxide synthase enzymes has been detected in Leishmania-infected animals. Besides its role on the immunity to infection, the role of NO and the inducible nitric oxide synthase (iNOS) in the pathogenesis of canine visceral leishmaniasis (CVL) is not well understood. This study aimed at evaluating immunohistochemically the iNOS expression in the spleen of dogs naturally infected (ID) with Leishmania (L.) chagasi compared with non-infected dogs (NID). The ID was grouped according to the clinical form and the parasite load. Symptomatic dogs (SD) presented higher parasite load in relation to oligosymptomatic (OD) and asymptomatic (AD). The qualitative expression of iNOS was observed only in ID. SD presented strong and prominent labeling of iNOS, followed by OD and AD. Quantitatively, the results showed that the median expression of iNOS was higher in SD and OD compared to NID. Also, dog spleens with high parasitism load showed marked iNOS expression. Taken together, the results suggest that the expression of iNOS in the spleen of infected dogs with CVL was associated with clinical worsening of the disease and with high parasitism.

  19. Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

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    Ananya Chatterjee

    2012-01-01

    Full Text Available The healing activity of gallic acid enriched ethanolic extract (GAE of Phyllanthus emblica fruits (amla against the indomethacin-induced gastric ulceration in mice was investigated. The activity was correlated with the ability of GAE to alter the cyclooxygenase- (COX- dependent healing pathways. Histology of the stomach tissues revealed maximum ulceration on the 3rd day after indomethacin (18 mg/kg, single dose administration that was associated with significant increase in inflammatory factors, namely, mucosal myeloperoxidase (MPO activity and inducible nitric oxide synthase (i-NOS expression. Proangiogenic parameters such as the levels of prostaglandin (PG E2, vascular endothelial growth factor (VEGF, hepatocyte growth factor (HGF, von Willebrand Factor VIII, and endothelial NOS (e-NOS were downregulated by indomethacin. Treatment with GAE (5 mg/kg/day and omeprazole (3 mg/kg/day for 3 days led to effective healing of the acute ulceration, while GAE could reverse the indomethacin-induced proinflammatory changes of the designated biochemical parameters. The ulcer healing activity of GAE was, however, compromised by coadministration of the nonspecific NOS inhibitor, N-nitro-L-arginine methyl ester (L-NAME, but not the i-NOS-specific inhibitor, L-N6-(1-iminoethyl lysine hydrochloride (L-NIL. Taken together, these results suggested that the GAE treatment accelerates ulcer healing by inducing PGE2 synthesis and augmenting e-NOS/i-NOS ratio.

  20. Science learning based on local potential: Overview of the nature of science (NoS) achieved

    Science.gov (United States)

    Wilujeng, Insih; Zuhdan Kun, P.; Suryadarma, IGP.

    2017-08-01

    The research concerned here examined the effectiveness of science learning conducted with local potential as basis from the point of a review of the NoS (nature of science) achieved. It used the non equivalent control group design and took place in the regions of Magelang and Pati, Province of Central Java, and the regions of Bantul and Sleman, Province of the Special Region of Yogyakarta. The research population consisted of students of the first and second grades at each junior high school chosen with research subjects sampled by means of cluster sampling. The instruments used included: a) an observation sheet, b) a written test, and c) a questionnaire. The learning and research instruments had been declared valid and reliable according to previous developmental research. In conclusion, the science learning based on local potential was effective in terms of all the NoS aspects.

  1. O papel da arte nos centros de atenção psicossocial - CAPS

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    Claudia Mara de Melo Tavares

    2003-02-01

    Full Text Available Estudo sobre o uso da abordagem artística nos cuidados desenvolvidos nos Centros de Atenção Psicossocial (CAPS. Fundamentado em bases conceituais da Reforma Psiquiátrica, o objeto de estudo foi abordado por meio de uma pesquisa exploratória de campo, através da entrevista com profissionais dos CAPS. Os resultados encontrados indicam que atividades de base artística são utilizadas visando a uma interação positiva com o usuário do serviço na perspectiva de sua reabilitação psicossocial. Concluímos que o trabalho no CAPS atualiza a potencialidade criativa dos profissionais e usuários, sendo a arte tomada como uma estratégia de cuidar.

  2. COMPORTAMENTO DOS PREÇOS NOS MERCADOS BRASILEIROS DE SUINOS, MILHO E SOJA

    OpenAIRE

    Rosado, Patricia Lopes; Gomes, Marilia Fernandes Maciel; Figueiredo, Adelson Martins

    2006-01-01

    O comportamento das séries históricas de preços de suínos e dos principais insumos usados no seu processo produtivo como, milho e soja, pode apresentar oscilações que o produtor, geralmente, não consegue prever, o que contribui para elevar o risco da atividade. Destarte, como forma de fornecer subsídios teóricos e empíricos aos agentes econômicos envolvidos em operações com suínos, milho e soja, buscou-se, neste trabalho, detectar a existência dos componentes estocásticos e, ou, determinístic...

  3. A CRISE DO PLANEJAMENTO DE TRANSPORTES NOS PAÍSES EM DESENVOLVIMENTO: REAVALIANDO PRESSUPOSTOS E ALTERNATIVAS

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    Eduardo A. Vasconcellos

    2010-04-01

    Full Text Available O artigo faz inicialmente uma sistematização dos problemas verificados nos países em desenvolvimento, como contribuição ao entendimento da crise urbana e seus efeitos sobre as condições de transporte, são sugeridos novos pressupostos e novos objetivos de orientação do processo de planejamento de transportes.

  4. A RELIGIOSIDADE POPULAR NOS EXERCÍCIOS ESPIRITUAIS DE SANTO INÁCIO DE LOYOLA

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    Victor Codina

    1987-01-01

    Full Text Available Uma primeira impressão frente ao texto e à prática dos Exercícios Espirituais de Santo Inácio (EE nos levaria à conclusão de que os EE se dirigem prioritariamente aos setores não populares da sociedade e da Igreja, e que tanto seu conteúdo como sua estrutura respondem a uma espiritualidade culta e quase elitista.

  5. Fracionamento de manganês acumulado nos tecidos de mudas de caramboleira

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    Amanda Hernandes

    2011-10-01

    Full Text Available A caramboleira (Averrhoa carambola tende a acumular grande quantidade de Mn nos seus tecidos, mas são escassas as informações sobre a forma como o excesso desse nutriente permanece na planta. Com o objetivo de contribuir para o esclarecimento desse aspecto, neste trabalho foram cultivadas mudas de caramboleira em solução nutritiva de Furlani (1999 com concentrações crescentes de Mn (0; 0,5; 25; e 50 mg L-1 de Mn, e aos 30, 60, 90 e 120 dias os tecidos de caule, folha e raiz foram colhidos e submetidos a uma sequência de soluções extratoras: água, DTPA (ácido dietilenotriaminopentacético e HCl (ácido clorídrico 1 mol L-1, com posterior determinação da quantidade de Mn nos extratos e nos tecidos remanescentes. Foram encontrados teores crescentes de Mn nos extratos de água, DTPA e HCl 1 mol L-1. A maior parte (cerca de 50 % do Mn permaneceu no tecido vegetal, mesmo após subsequentes extrações com as diferentes soluções extratoras, indicando que essa parte está fortemente ligada aos tecidos. Os maiores teores de Mn foram encontrados nas raízes e, os menores, no caule e nas folhas, sugerindo que a caramboleira tende a fixar o Mn nas raízes, possivelmente como mecanismo para limitar o transporte para a parte área, evitando a intoxicação da planta.

  6. Cumulative Author Index for Soviet Laser Bibliographies Nos. 67-93, September 1983-February 1989

    Science.gov (United States)

    1990-02-01

    C) 0 00 I: Cumulative Author Index for Soviet Laser Bibliographies September 1983 - February 1989 A Defense S&T Intelligence Special Purpose Document...90 CUMULATIVE AUTHOR INDEX FOR SOVIET LASER BIBLIOGRAPHIES Nos. 67-93 SEPTEMBER 1983 - FEBRUARY 1989 Date of Report March 31, 19 Vice Director for...RECIPIENT’S CATALOG NUMBER DST-2700Z-001-90 4. TITLE (and Subtitle) S. TYPE OF REPORT & PERIOD COVERED CUMULATIVE AUTHOR INDEX FOR SOVIET LASER

  7. Recommendations on AECB draft licensing guides nos. 40,41,42

    International Nuclear Information System (INIS)

    1981-06-01

    This report contains the recommendations of the Advisory Committee on Nuclear Safety (ACNS) to the Atomic Energy Control Board concerning the draft AECB Licensing Guides 40, 41 and 42 which were issued subsequently as Consultative Documents Nos. 7, 8 and 9. Since the report focusses on points of principle or generic concern, most of its recommendations apply generally to all three documents, although some specific recommendations are included [fr

  8. Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity.

    Science.gov (United States)

    Itzhak, Yossef; Anderson, Karen L; Ali, Syed F

    2004-10-01

    It has been shown that mice deficient in neuronal nitric oxide synthase (nNOS) gene are resistant to cocaine-induced psychomotor sensitization and methamphetamine (METH)-induced dopaminergic neurotoxicity. The present study was undertaken to investigate the hypothesis that nNOS has a major role in dopamine (DA)- but not serotonin (5-hydroxytryptamine; 5-HT)-mediated effects of psychostimulants. The response of nNOS knockout (KO) and wild-type (WT) mice to the psychomotor-stimulating and neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") and METH were investigated. Repeated administration of MDMA for 5 days resulted in psychomotor sensitization in both WT and nNOS KO mice, while repeated administration of METH caused psychomotor sensitization in WT but not in KO mice. Sensitization to both MDMA and METH was persistent for 40 days in WT mice, but not in nNOS KO mice. These findings suggest that the induction of psychomotor sensitization to MDMA and METH is NO independent and NO dependent, respectively, while the persistence of sensitization to both drugs is NO dependent. For the neurochemical studies, a high dose of MDMA caused marked depletion of 5-HT in several brain regions of both WT and KO mice, suggesting that the absence of the nNOS gene did not afford protection against MDMA-induced depletion of 5-HT. Striatal dopaminergic neurotoxicity caused by high doses of MDMA and METH in WT mice was partially prevented in KO mice administered with MDMA, but it was fully precluded in KO mice administered with METH. The differential response of nNOS KO mice to the behavioral and neurotoxic effects of MDMA and METH suggests that the nNOS gene is required for the expression and persistence of DA-mediated effects of METH and MDMA, while 5-HT-mediated effects of MDMA (induction of sensitization and 5-HT depletion) are not dependent on nNOS.

  9. Diagnosticos de enfermagem em pacientes classificados nos niveis I e II de prioridade do Protocolo Manchester

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    Cristiane Chaves de Souza

    2013-12-01

    Full Text Available O estudo objetivou identificar possíveis diagnósticos de enfermagem em pacientes classificados nos níveis I e II de prioridade do protocolo Manchester. Trata-se de estudo descritivo retrospectivo, cuja amostra foi de 40 prontuários de pacientes classificados nos níveis I e II de prioridade. Para identificação dos diagnósticos de enfermagem dois especialistas analisaram sinais e sintomas registrados nos prontuários dos pacientes no momento da classificação de risco. No nível I de prioridade, os diagnósticos de enfermagem mais frequentes foram: dor aguda (65,0%, padrão respiratório ineficaz (45,0% e troca de gases prejudicada (40,0%. No nível II de prioridade foram: dor aguda (80,0%, náusea (10,0% e risco de desequilíbrio eletrolítico (10,0%. Percebeu-se que a utilização do protocolo de Manchester favorece a identificação de características definidoras e fatores relacionados/fatores de risco que subsidiam a elaboração de diagnósticos de enfermagem na classificação de risco.

  10. Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.

    Science.gov (United States)

    Krieg, Thomas; Qin, Qining; Philipp, Sebastian; Alexeyev, Mikhail F; Cohen, Michael V; Downey, James M

    2004-12-01

    In the rabbit heart, bradykinin and ACh trigger preconditioning by a mechanism involving ATP-sensitive potassium channel-dependent production of reactive oxygen species (ROS). Recent evidence indicates that the pathway by which bradykinin causes ROS generation includes nitric oxide synthase (NOS) and protein kinase G (PKG). On the other hand, Akt was shown to be essential for ACh to generate ROS. This study determines whether these two G-coupled receptor agonists indeed have similar signaling targets, i.e., whether Akt is involved in bradykinin's pathway and whether NOS is involved in ACh's pathway. Isolated adult rabbit cardiomyocytes were incubated for 15 min in reduced MitoTracker red, which becomes fluorescent only after exposure to ROS. Bradykinin (400 nM) and ACh (250 microM) caused a 51.4 +/- 14.8% and 39.8 +/- 11.7% increase, respectively, in ROS production (P hydrochloride (L-NIO, 5 microM). L-NIO also blocked the anti-infarct effect of ACh (550 microM) in isolated rabbit hearts exposed to 30 min of regional ischemia. We conclude that both bradykinin and ACh trigger ROS generation by sequentially activating Akt and NOS.

  11. Anemia nos pacientes com insuficiência cardíaca avançada

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    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.

  12. Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China

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    Yingjie Dai

    2013-01-01

    Full Text Available Nitric oxide (NO is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757. Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P=0.037, P=0.041. After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes, AG genotype and A allele were still related to ischemic stroke (OR=0.572, 95% CI: 0.335–0.978, P=0.041; OR=0.611, 95% C: 0.378–0.985, and P=0.041 and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.

  13. Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kuzmanić Šamija, R. [Department of Pediatrics, University Hospital Split, Split (Croatia); Primorac, D. [School of Medicine Split, University of Split, Split (Croatia); Department of Pediatrics, School of Medicine, University of Osijek, Osijek (Croatia); Eberly College of Science, Penn State University, University Park, PA (United States); St. Catherine Speciality Hospital, Zabok (Croatia); Rešić, B. [School of Medicine Split, University of Split, Split (Croatia); Pavlov, V. [Department of Neonatology, University Hospital Split, Split (Croatia); Čapkun, V. [Department of Nuclear Medicine, University Hospital Split, Split (Croatia); Punda, H. [School of Medicine Split, University of Split, Split (Croatia); Lozić, B. [Department of Pediatrics, University Hospital Split, Split (Croatia); Zemunik, T. [Department of Medical Biology, School of Medicine Split, University of Split, Split (Croatia)

    2014-08-15

    The aim of this study was to analyze the association of different clinical contributors of hypoxic-ischemic encephalopathy with NOS3 gene polymorphisms. A total of 110 children with hypoxic-ischemic encephalopathy and 128 control children were selected for this study. Association of gender, gestational age, birth weight, Apgar score, cranial ultrasonography, and magnetic resonance imaging findings with genotypic data of six haplotype-tagging single nucleotide polymorphisms and the most commonly investigated rs1800779 and rs2070744 polymorphisms was analyzed. The TGT haplotype of rs1800783, rs1800779, and rs2070744 polymorphisms was associated with hypoxic-ischemic encephalopathy. Children with the TGT haplotype were infants below 32 weeks of gestation and they had the most severe brain damage. Increased incidence of the TT genotype of the NOS3 rs1808593 SNP was found in the group of hypoxic-ischemic encephalopathy patients with medium and severe brain damage. The probability of brain damage was twice as high in children with the TT genotype than in children with the TG genotype of the same polymorphism. Furthermore, the T allele of the same polymorphism was twice as frequent in children with lower Apgar scores. This study strongly suggests associations of NOS3 gene polymorphism with intensity of brain damage and severity of the clinical picture in affected children.

  14. Música da Borda d'Água: nos textos e imagens de Alves Redol

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    Domingos Morais

    2013-01-01

    Full Text Available António Alves Redol, escritor português natural de Vila Franca de Xira, nasceu a 29 de dezembro de 1911 e faleceu a 29 de novembro de 1969. Figura central do Neorrealismo português, foi autor de uma vasta obra ficcional, que inclui o teatro e o conto. Na noite de 25 de outubro de 1940, no Sport Lisboa e Vila Franca, realizou uma palestra sobre a "Música da Borda d'Água" de que não há registo conhecido. Tentamos refazer essa palestra, ou pelo menos as linhas orientadoras do seu discurso, recorrendo a textos de Redol, alguns inéditos, dos anos de 1938 e 1939, que nos foi possível consultar e digitalizar nos acervos do seu filho, António Mota Redol, em outubro de 2012. Na obra de Redol, as referências à música e dança são estruturantes das situações que descreve. Sem entrar em detalhes técnicos que talvez ignorasse, o que nos diz é revelador de como o movimento neorrealista, que tem em Fernando Lopes-Graça um solitário mentor, não descurou os repertórios e cancioneiros populares, contrapondo-os às práticas e gostos musicais das classes dominantes.

  15. Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy

    International Nuclear Information System (INIS)

    Kuzmanić Šamija, R.; Primorac, D.; Rešić, B.; Pavlov, V.; Čapkun, V.; Punda, H.; Lozić, B.; Zemunik, T.

    2014-01-01

    The aim of this study was to analyze the association of different clinical contributors of hypoxic-ischemic encephalopathy with NOS3 gene polymorphisms. A total of 110 children with hypoxic-ischemic encephalopathy and 128 control children were selected for this study. Association of gender, gestational age, birth weight, Apgar score, cranial ultrasonography, and magnetic resonance imaging findings with genotypic data of six haplotype-tagging single nucleotide polymorphisms and the most commonly investigated rs1800779 and rs2070744 polymorphisms was analyzed. The TGT haplotype of rs1800783, rs1800779, and rs2070744 polymorphisms was associated with hypoxic-ischemic encephalopathy. Children with the TGT haplotype were infants below 32 weeks of gestation and they had the most severe brain damage. Increased incidence of the TT genotype of the NOS3 rs1808593 SNP was found in the group of hypoxic-ischemic encephalopathy patients with medium and severe brain damage. The probability of brain damage was twice as high in children with the TT genotype than in children with the TG genotype of the same polymorphism. Furthermore, the T allele of the same polymorphism was twice as frequent in children with lower Apgar scores. This study strongly suggests associations of NOS3 gene polymorphism with intensity of brain damage and severity of the clinical picture in affected children

  16. Mormo em eqüídeos nos Estados de Pernambuco e Alagoas

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    Mota Rinaldo A.

    2000-01-01

    Full Text Available Com base em aspectos clínico-patológicos, epidemiológicos e sorológicos, bem como pelo isolamento de Burkholderia mallei, diagnosticaram-se focos de mormo em eqüídeos na Zona da Mata dos Estados de Pernambuco e Alagoas. Clinicamente observaram-se hipertermia, respiração ruidosa, inapetência, emagrecimento progressivo até caquexia, congestão nasal e descarga mucopurulenta, erosões, úlceras e cicatrizes na mucosa nasal. Os linfonodos mandibulares e cervicais superficiais apresentavam-se aumentados de volume, com abscessos e fístulas exsudando material purulento. Na pele, ao longo dos vasos linfáticos, havia formação de nódulos firmes e abscessos que, nos casos crônicos, fistulavam e ulceravam deixando cicatrizes estrelares. A histopatologia dos nódulos de diversos sítios, tanto dos eqüídeos como dos cobaios utilizados na prova de Straus, revelou lesões granulomatosas e piogranulomas. Os dados deste estudo evidenciam a emergência da doença nesta área e permitem recomendar inquéritos soro-epidemiológicos nos Estados de ocorrência dos surtos e nos Estados limítrofes.

  17. PEDAGOGIA NOS CURSOS DE PEDAGOGIA? da ausência e dos impactos no trabalho pedagógico

    OpenAIRE

    Liliana Soares Ferreira

    2017-01-01

    Esse artigo sistematiza pesquisa realizada nos últimos cinco anos, com o objetivo de estudar os movimentos de sentidos, a historicidade e o trabalho de pedagogas(os) (e, portanto, trabalho pedagógico) descritos nos projetos pedagógicos dos cursos de Pedagogia gaúchos. Com base nesse estudo inicial, objetivou-se entender qual concepção de Pedagogia e de trabalho pedagógico das futuras(os) pedagogas(os) estão na base da elaboração desses projetos pedagógicos e nos discursos de gestores desses c...

  18. KONSUMSI MIKRONUTRIEN DAN EKSPRESI GEN eNOS3 ALEL INTRO 4a4b PADA PENDERITA HIPERTENSI ETNIK MINANGKABAU

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    Delmi Sulastri

    2011-05-01

    Full Text Available AbstrakGen eNOS3 varian intron 4a4b merupakan salah satu gen yang berhubungan dengan kejadian hipertensi esensial. Kemampuan Gen eNOS3 varian ini untuk mensintesis enzim nitric oxide synthase (NOS berkurang sehingga sintesis Nitric oxide (NO menurun. Senyawa NO adalah suatu senyawa vasoaktif yang menyebabkan vasodilatasi pembuluh darah.Penelitian pada subjek hipertensi dan normotensi berusia 30-65 tahun bertujuan untuk melihat pengaruh mikronutrien terhadap ekspresi gen eNOS3 alel intron 4a4b. 130 subjek, diwawancara pola makannya lalu dilakukan analisis asupan mikronutrien, gen eNOS3, serta kadar NO plasma. Data yang diperoleh dianalisis menggunakan uji T dan chi-square.Kadar NO plasma penderita hipertensi adalah 26.91 + 15.40 μM/L dan normotensi 25.79 + 15.04 μM/L. 55.5% subjek hipertensi memiliki gen eNOS3 varian intron 4b dan 69% subjek normotensi mempunyai varian intron 4a4b. Kadar NO plasma rendah, (66.7% ditemukan pada subjek hipertensi dengan varian intron 4b. Tidak terdapat hubungan bermakna asupan mikronutrien dengan kadar NO plasma pada subjek hipertensi.Hasil ini tidak mendukung pengaruh konsumsi mikronutrien terhadap kadar NO plasma pada penderita hipertensi dengan gen eNOS3 varian intron 4a4b.Kata Kunci : hipertensi esensial, gen eNOS3, kadar NO plasmaAbstracteNOS 3 gene intron 4a4b allel is one of the important genes which is related to hypertesion essensial. This gene expresses the nitric oxide synthase (NOS enzyme which regulates the synthesis of Nitric oxide (NO in human body. NO causes vasodilatation, which decreases peripheral resistant and blood pressure.A research has been done based on cross sectional study on hypertension patients and those with normal blood pressure in the range of 30-65 years old. The main of this research is to evaluate the influence of micronutrient consumption on eNOS3 gene intron 4a4b allel expression in hypertension subjects in Minangkabau ethnicity. 130 subjects interviewed about micronutrient

  19. The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

    International Nuclear Information System (INIS)

    Simon, Priscilla S.; Sharman, Sarah K.; Lu, Chunwan; Yang, Dafeng; Paschall, Amy V.; Tulachan, Sidhartha S.; Liu, Kebin

    2015-01-01

    Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvironment. Compelling experimental data have shown that iNOS promotes tumor development in certain cellular context and suppresses tumor development in other cellular conditions. The molecular mechanisms underlying these contrasting functions of iNOS is unknown. Because iNOS is often induced by inflammatory signals, it is therefore likely that these contrasting functions of iNOS could be controlled by the inflammatory signaling pathways, which remains to be determined. iNOS is expressed in colon carcinoma and myeloid cells in the tumor microenvironment. Colon carcinoma and myeloid cell lines were used to elucidate the molecular mechanisms underlying iNOS expression. Chromatin immunoprecipitation and electrophoretic mobility shift assay were used to determine the IFNγ-activated pSTAT1 and NF-κB association with the chromatin DNA of the nos2 promoter. We show here that iNOS is dramatically up-regulated in inflammed human colon tissues and in human colon carcinoma as compared to normal colon tissue. iNOS is expressed in either the colon carcinoma cells or immune cells within the tumor microenvironment. On the molecular level, the proinflammatory IFNγ and NF-κB signals induce iNOS expression in human colon cancer cells. We further demonstrate that NF-κB directly binds to the NOS2 promoter to regulate iNOS expression. Although neither the IFNγ signaling pathway nor the NF-κB signaling pathway alone is sufficient to induce iNOS expression in myeloid cells, IFNγ and NF-κB synergistically induce iNOS expression in myeloid cells. Furthermore, we determine that IFNγ up-regulates IRF8 expression to augment NF-κB induction of iNOS expression. More interestingly, we

  20. Final environmental statement related to the proposed manufacture of floating nuclear power plants: (Docket No. STN 50-437): Part 2, A generic environmental statement considering the siting and operation of floating nuclear power plants

    International Nuclear Information System (INIS)

    1976-09-01

    The proposed action is the issuance of a manufacturing license to Offshore Power Systems for the startup and operation of a proposed manufacturing facility located at Blount Island, Jacksonville, Florida (Docket No. STN 50-437). No nuclear fuel will be handled or stored at the manufacturing site. The plants will be fueled after they have been towed to and moored within protected basins at specific locations designated by the purchaser and after an operating license has been issued by the Nuclear Regulatory Commission. Each nuclear generating plant, mounted on a floating platform, has a net capacity of 1150 MWe. This energy is provided by a pressurized water reactor steam supply system consisting of a Westinghouse four-loop 3425-MWt unit with an ice-condenser containment system. When one or more of these units is located within a single breakwater, the installation is designated an offshore power station. 226 figs., 95 tabs