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Sample records for dm diet education

  1. [Development of a multimedia learning DM diet education program using standardized patients and analysis of its effects on clinical competency and learning satisfaction for nursing students].

    Science.gov (United States)

    Hyun, Kyung Sun; Kang, Hyun Sook; Kim, Won Ock; Park, Sunhee; Lee, Jia; Sok, Sohyune

    2009-04-01

    The purpose of this study was to develop a multimedia learning program for patients with diabetes mellitus (DM) diet education using standardized patients and to examine the effects of the program on educational skills, communication skills, DM diet knowledge and learning satisfaction. The study employed a randomized control posttest non-synchronized design. The participants were 108 third year nursing students (52 experimental group, 56 control group) at K university in Seoul, Korea. The experimental group had regular lectures and the multimedia learning program for DM diet education using standardized patients while the control group had regular lectures only. The DM educational skills were measured by trained research assistants. The students who received the multimedia learning program scored higher for DM diet educational skills, communication skills and DM diet knowledge compared to the control group. Learning satisfaction of the experimental group was higher than the control group, but statistically insignificant. Clinical competency was improved for students receiving the multimedia learning program for DM diet education using standardized patients, but there was no statistically significant effect on learning satisfaction. In the nursing education system there is a need to develop and apply more multimedia materials for education and to use standardized patients effectively.

  2. Intensified glucose self-monitoring with education in Saudi DM patients.

    Science.gov (United States)

    Ba-Essa, Ebtesam M; Mobarak, Eman I; Alghamdi, Abdulaziz; Al-Daghri, Nasser M

    2015-01-01

    The purpose of this study is to assess the impact of intensified SMBG with patient education on DM patients at the Eastern province of Saudi Arabia. 60 poorly controlled adult type 1 and 2 DM patients (30 intervention; 30 control) were included in this 4-month case-control study. All patients were subjected to the same educational program at baseline. Controls were followed up after 3 months. The intervention group was followed monthly. Fasting blood glucose, HbA1c and lipid profile levels were the main outcome measures. The intervention arm showed significant reduction in the post-fasting glucose (P<0.001) and HbA1c (P<0.001) levels as well as a significant increase in glucose testing (P<0.001) than pre-levels. Both post-fasting glucose and HbA1c levels were significantly lower in the intervention arm than the control arm (P<0.001 and P=0.001, respectively). The intervention group also showed higher improvement in knowledge, attitude and behavior than the controls (P<0.001). Short duration of structured periodic SMBG with patient education significantly improved glycemic control in all DM patients, regardless of the type or mode of treatment. It facilitated timely and aggressive treatment modification and encouraged patient self-care behavior.

  3. Site of initial diabetes education does not affect metabolic outcomes in children with T1DM.

    Science.gov (United States)

    Tonyushkina, Ksenia N; Visintainer, Paul F; Jasinski, Christopher F; Wadzinski, Thomas L; Allen, Holley F

    2014-03-01

    To determine the difference in metabolic outcomes at 1 and 2 yr post type 1 diabetes mellitus (T1DM) diagnosis in children depending on the site of initial diabetes education: inpatient, vs. outpatient, vs. mixed locations. A retrospective chart review was performed for all patients with new onset antibody positive T1DM, aged 1-18 yr old, diagnosed in 2004-2009, and followed for at least 1 yr in a diabetes program at a tertiary academic health care center. Patients were divided into three groups based on the site of initial diabetes education: inpatient, outpatient, and mixed locations. The primary outcome was A1c at 1 and 2 yr. We enrolled 238 children (133 boys), mean (± SD) age 9.9 (± 4.1). A1c levels did not differ among inpatient, outpatient, and mixed location groups at 1 and 2 yr post diagnosis (p = 0.85 and p = 0.69, respectively) and the long-acting insulin doses were similar at 1 and 2 yr (p = 0.18 and p = 0.15, respectively). There was no difference in the number of acute diabetes complications between the groups. At 1 yr, 21.8% of outpatient-educated children were on insulin pump therapy in contrast to 14.7% of inpatient and 2.7% of mixed educated groups (p = 0.04). Families of children with new onset T1DM can be successfully and safely educated in a clinic setting. An 'education' admission for a medically stable patient is not necessary most of the time, however, clinical judgment and careful assessment of the family's coping and learning capabilities are important when determining the site of education. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Dermatomyositis (DM)

    Science.gov (United States)

    ... Favorite Name: Category: Share: Yes No, Keep Private Dermatomyositis Share | Dermatomyositis (DM) is a rare inflammatory muscle disease that ... drugs, and infectious agents) in genetically predisposed individuals. Dermatomyositis can occur with other connective tissue disorders such ...

  5. A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial.

    Science.gov (United States)

    Whittaker, Anne; Dinu, Monica; Cesari, Francesca; Gori, Anna Maria; Fiorillo, Claudia; Becatti, Matteo; Casini, Alessandro; Marcucci, Rossella; Benedettelli, Stefano; Sofi, Francesco

    2017-04-01

    The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: -3.7 and -3.4 %, respectively), insulin (-16.3 %) and blood glucose (-9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat.

  6. Implementation of Hybrid DCT/DPCM Video-Encoder in the DM642 EVM for Educational Purposes

    Directory of Open Access Journals (Sweden)

    Jozef Huska

    2006-01-01

    Full Text Available There is presented implementation of hybrid DCT/DPCM video-encoder in the power ful TI’s media processor TMS320DM642 embed in evaluation module DM642 EVM. Code Composer Studio 3 is used as working space. Videoencoder is implemented with use of C code so it is easily understandable. The easiness is very important because the implemented video-encoder will be used for educational purposes. The structure of the encoder is lightly recognizable forstudents frequenting the courses Analog and Digital Television, Digital Image Processing and Encoding so some routines could lightly modified.

  7. Educational Interactive eBook for Newly Diagnosed Children with T1DM: Children’s Role in Design

    Directory of Open Access Journals (Sweden)

    Damyanka Tsvyatkova

    2015-12-01

    Full Text Available Some of the central concerns in technology development for healthcare interventions in Type 1 Diabetes Mellitus (T1DM are how to involve young patients and their families in the design process and what methods, including artbased activities, would best facilitate a child expressing their innermost feelings when applying child-centered and participatory approaches. This paper describes a variety of artbased tools and methods (e.g. Cooperative Inquiry (CI and Informant Design (ID used in the creative design processes for defining features and eliciting the content of the stories, plots, roles, characters, images, animations, languages, etc., that will inform the design of an educational interactive eBook for newly diagnosed children (aged 8-12 years with T1DM. The articulation of design ideas through modeling plasticine figures, drawing and thinking aloud were generated and collected in three workshop sessions organized for diabetic and healthy children who had different roles in and contributions to the design process. Successfully collected data will be used to build a series of low fidelity paper based eBook prototypes.

  8. Preface Gi4DM

    NARCIS (Netherlands)

    Zlatanova, S.; Sithole, G.; Nakagawa, M.; Zhu, Q.

    2015-01-01

    Gi4DM 2015 marks the 10th edition of the Geoinformation for Disaster Management series of conferences. The first conference in 2005 was held in the aftermath of the 2004 Indian Ocean earthquake and tsunami which claimed the lives of over 220000 civilians. While Geoinformatics has a long been used in

  9. Maternal education and intelligence predict offspring diet and nutritional status.

    Science.gov (United States)

    Wachs, Theodore D; Creed-Kanashiro, Hilary; Cueto, Santiago; Jacoby, Enrique

    2005-09-01

    The traditional assumption that children's nutritional deficiencies are essentially due either to overall food scarcity or to a lack of family resources to purchase available food has been increasingly questioned. Parental characteristics represent 1 type of noneconomic factor that may be related to variability in children's diets and nutritional status. We report evidence on the relation of 2 parental characteristics, maternal education level and maternal intelligence, to infant and toddler diet and nutritional status. Our sample consisted of 241 low-income Peruvian mothers and their infants assessed from 3 to 12 mo, with a further follow-up of 104 of these infants at 18 mo of age. Using a nonexperimental design, we related measures of level of maternal education, maternal intelligence, and family socioeconomic status to infant anthropometry, duration of exclusive breast-feeding, adequacy of dietary intake, and iron status. Results indicated unique positive relations between maternal education level and the extent of exclusive breast-feeding. Significant relations between maternal education and offspring length were partially mediated by maternal height. There also were unique positive relations between maternal intelligence and quality of offspring diet and hemoglobin level. All findings remained significant even after controlling for family socioeconomic characteristics. This pattern of results illustrates the importance of parental characteristics in structuring the adequacy of offspring diet. Maternal education and intelligence appear to have unique influences upon different aspects of the diet and nutritional status of offspring.

  10. Are Fad Diets Good for Education?

    Science.gov (United States)

    Hunter, Bruce

    1990-01-01

    Argues that the goal of quality education for every child requires fundamental change in the process of teaching and learning. Criticizes the treatment of educational choice as the most important single education reform because it does not improve the learning environment of every child. Encourages avoidance of state entanglement in religion. (DK)

  11. Ubiquitous CM and DM

    Science.gov (United States)

    Crowley, Sandra L.

    2000-01-01

    Ubiquitous is a real word. I thank a former Total Quality Coach for my first exposure some years ago to its existence. My version of Webster's dictionary defines ubiquitous as "present, or seeming to be present, everywhere at the same time; omnipresent." While I believe that God is omnipresent, I have come to discover that CM and DM are present everywhere. Oh, yes; I define CM as Configuration Management and DM as either Data or Document Management. Ten years ago, I had my first introduction to the CM world. I had an opportunity to do CM for the Space Station effort at the NASA Lewis Research Center. I learned that CM was a discipline that had four areas of focus: identification, control, status accounting, and verification. I was certified as a CMIl graduate and was indoctrinated about clear, concise, and valid. Off I went into a world of entirely new experiences. I was exposed to change requests and change boards first hand. I also learned about implementation of changes, and then of technical and CM requirements.

  12. Self-Regulation of Physical Education Teacher Education Students' Attitudes towards Exercise and Diet

    Science.gov (United States)

    Wilkinson, Carol; Prusak, Keven

    2013-01-01

    The purpose of this study was to assess differences in self-regulation of attitudes towards engaging in exercise and eating a healthy diet between physical education teacher education (PETE) students and general education (GE) students, and between male students and female students. Participants were university students (n = 194) at a university…

  13. Rich, Well-Educated Get Bigger Bang for Buck from Mediterranean Diet

    Science.gov (United States)

    ... Well-Educated Get Bigger Bang for Buck From Mediterranean Diet Researchers suspect food quality may account for ... 2017 TUESDAY, Aug. 1, 2017 (HealthDay News) -- The Mediterranean diet -- rich in fruits, vegetables, fish, olive oil, ...

  14. Association between maternal education and diet of children at 9 months is partially explained by mothers' diet.

    Science.gov (United States)

    Lioret, Sandrine; Cameron, Adrian J; McNaughton, Sarah A; Crawford, David; Spence, Alison C; Hesketh, Kylie; Campbell, Karen J

    2015-10-01

    Infants of mothers of low educational background display consistently poorer outcomes, including suboptimal weaning diets. Less is known about the different causal pathways that relate maternal education to infants' diet. The present study aimed to test the hypothesis that the relationship between maternal education and infants' diet is mediated by mothers' diet. The analyses included 421 mother-infant pairs from the Melbourne Infant Feeding Activity and Nutrition Trial (InFANT) Program. Dietary intakes were collected from mothers when infants were aged 3 months, using a validated food frequency questionnaire relating to the past year, and in infants aged 9 months using 3 × 24-h recalls. Principal component analysis was used to derive dietary pattern scores, based on frequencies of 55 food groups in mothers, and intakes of 23 food groups in infants. Associations were assessed with multivariable linear regression. We tested the product 'ab' to address the mediation hypothesis, where 'a' refers to the relationship between the predictor variable (education) and the mediator variable (mothers' diet), and 'b' refers to the association between the mediator variable and the outcome variable (infants' diet), controlling for the predictor variable. Maternal scores on the 'Fruit and vegetables' dietary pattern partially mediated the relationships between maternal education and two infant dietary patterns, namely 'Balanced weaning diet' [ab = 0.11; 95% confidence interval (CI): 0.04; 0.18] and 'Formula' (ab = -0.08; 95%CI: -0.15; -0.02). These findings suggest that targeting pregnant mothers of low education level with the aim of improving their own diet may also promote better weaning diets in their infants.

  15. Efectividad de la educación diabetológica sistematizada en niños que debutan con Diabetes Mellitus tipo 1 Effectiveness of systematic diabetes education in children diagnosed with Diabetes Mellitus type 1 (DM1

    Directory of Open Access Journals (Sweden)

    Manuel Montilla-Pérez

    2012-06-01

    Full Text Available Objetivo principal: Evaluar la efectividad de la educación diabetológica sistematizada en niños que debutan con DM1 en el Hospital Universitario de Fuenlabrada (HUF, Madrid. Metodología: Estudio comparativo entre dos muestras de niños de 0 a 14 años que debutaron con DM1 antes y después de haberse instaurado un programa de educación diabetológica Se estudió a 34 niños adscritos al HUF que ingresaron por debut de DM1. Para evaluar la efectividad del programa se realizaron análisis bivariados con el fin de encontrar relaciones entre la educación diabetológica sistematizada y las variables: días de ingreso, frecuentación a urgencias por complicaciones, permisos domiciliarios y HbA1c a los 3 y 6 meses del alta. Resultados principales: Los días de ingreso se redujeron 3 días (pObjective: Evaluate the effectiveness of systematic diabetes education in children diagnosed with Diabetes Mellitus type 1 (DM1, in Fuenlabrada University Hospital (Madrid. Methods: A comparative study of two sample groups of children aged 0 to 14 diagnosed with DM1, before and after having been inducted into the diabetes education program. 34 children, admitted with a DM1 diagnosis, both with and without ketoacidosis, and assigned to Fuenlabrada University Hospital were studied. To evaluate the effectiveness of the program, bivariable analysis was undertaken with the objective of finding relationships between systematic diabetes education and the variables. Those variables were; admission days, frequency of visits to the emergency ward due to complications, and permissions to go home and HbA1c at 3 to 6 months after discharge from the hospital. Results: The admission days was reduced 3 days (p< 0.001, the complications within the 6 month after discharge decreased 41,2% and the permissions to go home increased 23,6% (p=0.001. Conclusions: The results of the study suggest the effectiveness of systematic diabetes education.

  16. Diets

    Science.gov (United States)

    ... prevent weight-related diseases, such as heart disease, diabetes, arthritis and some cancers. A healthy diet is an important part of a weight-loss ... you to lose weight. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  17. Relationships between Unbalanced Diets of Students Training to be National Registered Dietitians and Their Views on Food Education

    OpenAIRE

    江田, 節子

    2008-01-01

    About 90% of the students thought unbalanced diets are undesirable whether they took balanced or unbalanced diets. However, although the students were willing to participate in general food education as a nutritional counselor in the future, those who took unbalanced diets were less enthusiastic in guidance for correcting unbalanced diets than those who took balanced diets. The data confirmed that the students had received a limited amount of guidance for correcting unbalanced diets at school...

  18. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.

    Science.gov (United States)

    Quach, Austin; Levine, Morgan E; Tanaka, Toshiko; Lu, Ake T; Chen, Brian H; Ferrucci, Luigi; Ritz, Beate; Bandinelli, Stefania; Neuhouser, Marian L; Beasley, Jeannette M; Snetselaar, Linda; Wallace, Robert B; Tsao, Philip S; Absher, Devin; Assimes, Themistocles L; Stewart, James D; Li, Yun; Hou, Lifang; Baccarelli, Andrea A; Whitsel, Eric A; Horvath, Steve

    2017-02-14

    Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-cause mortality, chronic conditions, and age-related functional decline. We analyze cross-sectional data from 4,173 postmenopausal female participants from the Women's Health Initiative, as well as 402 male and female participants from the Italian cohort study, Invecchiare nel Chianti.Extrinsic epigenetic age acceleration (EEAA) exhibits significant associations with fish intake (p=0.02), moderate alcohol consumption (p=0.01), education (p=3x10(-5)), BMI (p=0.01), and blood carotenoid levels (p=1x10(-5))-an indicator of fruit and vegetable consumption, whereas intrinsic epigenetic age acceleration (IEAA) is associated with poultry intake (p=0.03) and BMI (p=0.05). Both EEAA and IEAA were also found to relate to indicators of metabolic syndrome, which appear to mediate their associations with BMI. Metformin-the first-line medication for the treatment of type 2 diabetes-does not delay epigenetic aging in this observational study. Finally, longitudinal data suggests that an increase in BMI is associated with increase in both EEAA and IEAA.Overall, the epigenetic age analysis of blood confirms the conventional wisdom regarding the benefits of eating a high plant diet with lean meats, moderate alcohol consumption, physical activity, and education, as well as the health risks of obesity and metabolic syndrome.

  19. An educational model for improving diet counselling in primary care. A case study of the creative use of doctors' own diet, their attitudes to it and to nutritional counselling of their patients with diabetes

    DEFF Research Database (Denmark)

    Olivarius, Niels de Fine; Palmvig, Birthe; Andreasen, Anne Helms;

    2005-01-01

    Nutritional counseling; Nutritional education; Nutritional assessment; Primary care; Continuing medical education; Doctors' diet; Doctors attitudes; Doctors' knowledge; Body mass index; Educational model; Food frequency questionaire......Nutritional counseling; Nutritional education; Nutritional assessment; Primary care; Continuing medical education; Doctors' diet; Doctors attitudes; Doctors' knowledge; Body mass index; Educational model; Food frequency questionaire...

  20. Is maternal education level associated with diet in 10-year-old children?

    Science.gov (United States)

    Cribb, Victoria L; Jones, Louise R; Rogers, Imogen S; Ness, Andrew R; Emmett, Pauline M

    2011-11-01

    To examine the associations between maternal education level and diet in 10-year-old children. Three-day diet diaries (child completed with parental help) were collected. Height and weight were measured in research clinics. Maternal education level was derived from a questionnaire completed during pregnancy and classified into low, medium or high. One-way ANOVA was undertaken to compare maternal education groups for nutrient intakes and the Kruskal-Wallis test used for food consumption. Avon Longitudinal Study of Parents and Children (ALSPAC), Bristol, UK. Children (n 7474) who provided dietary data at age 10 years. A large proportion (60 %) of the sample was classified as plausible reporters, with under-reporting accounting for 36 %. No clear differences were found for intakes of energy or macronutrients between maternal education groups for plausible reporters. However, there were marked differences in micronutrient intakes especially for vitamin C, retinol equivalents and folate, highlighting lower diet quality with lower maternal education level. Intakes of fruit and vegetables showed a positive gradient with increasing maternal education (57 % v. 79 % consumed fresh fruit in low and high educational groups, respectively). A trend towards higher intake in the lower educated group was shown for less healthy foods (meat pies P education level. Lower maternal education was associated with less healthy food choices that could be detrimental to health. Further research is needed to establish if these associations can be explained by other socio-economic factors.

  1. Diets of the Elderly, Nutrition Labeling and Nutrition Education

    Science.gov (United States)

    Pao, Eleanor M.; Hill, Mary M.

    1974-01-01

    Nutrition labeling regulations introduce United States-Recommended Daily Allowances (RDAs) or higher values than current NRC-RDAs for elderly people. Since few elderly diets met the lower recommendations ways to use the new nutrition information are suggested. (Author/RH)

  2. Diets of the Elderly, Nutrition Labeling and Nutrition Education

    Science.gov (United States)

    Pao, Eleanor M.; Hill, Mary M.

    1974-01-01

    Nutrition labeling regulations introduce United States-Recommended Daily Allowances (RDAs) or higher values than current NRC-RDAs for elderly people. Since few elderly diets met the lower recommendations ways to use the new nutrition information are suggested. (Author/RH)

  3. Recipe for Burnout: The Special Education Teachers' Diet.

    Science.gov (United States)

    Bradfield, Robert H.; Fones, Donald M.

    1984-01-01

    Computerized diet analysis of 41 teachers of learning disabled students revealed deficiencies in carbohydrate, fiber, and micronutrient intake and excessive fat and protein intake. Findings suggested that poor dietary habits may make Ss more susceptible to emotional stress and physical illness. (CL)

  4. Educating dental students about diet-related behavior change: does experiential learning work?

    Science.gov (United States)

    Taylor, George W; Stumpos, Madelyn L; Kerschbaum, Wendy; Inglehart, Marita Rohr

    2014-01-01

    The objective of this study was to explore whether an experiential exercise in a nutrition class would a) increase dental students' motivation to change their own diet-related behavior, b) improve their understanding of theoretical concepts related to behavior change, and c) improve their attitudes towards educating their patients about diet-related behavior. Data were collected from 218 senior dental students in one dental school (2010: 106; 2011: 112) during their nutrition class. The students agreed at the beginning that it was important to change their own diet-related behavior. After one week, the majority agreed that they had changed how they felt and thought about the targeted behavior and what they actually did. After three weeks and at the end of the term, they rated the exercise as helpful for gaining a better understanding of health education theories. The majority indicated that the exercise had helped them understand the difficulty of diet-related behavior change and that it had increased their interest in helping patients change their diet-related behavior. In conclusion, this study suggests that experiential learning about diet-related behavior change is likely to affect students' own behavior positively and to result in increased understanding of behavior change theories and positive behavioral intentions concerning future health education efforts with patients.

  5. Diet quality of Americans differs by age, sex, race/ethnicity, income, and education level.

    Science.gov (United States)

    Hiza, Hazel A B; Casavale, Kellie O; Guenther, Patricia M; Davis, Carole A

    2013-02-01

    An index that assesses the multidimensional components of the diet across the lifecycle is useful in describing diet quality. The purpose of this study was to use the Healthy Eating Index-2005, a measure of diet quality in terms of conformance to the 2005 Dietary Guidelines for Americans, to describe the diet quality of Americans by varying sociodemographic characteristics in order to provide insight as to where diets need to improve. The Healthy Eating Index-2005 scores were estimated using 1 day of dietary intake data provided by participants in the 2003-2004 National Health and Nutrition Examination Survey. Mean daily intakes of foods and nutrients, expressed per 1,000 kilocalories, were estimated using the population ratio method and compared with standards that reflect the 2005 Dietary Guidelines for Americans. Participants included 3,286 children (2 to 17 years), 3,690 young and middle-aged adults (18 to 64 years), and 1,296 older adults (65+ years). Results are reported as percentages of maximum scores and tested for significant differences (P ≤ 0.05) by age, sex, race/ethnicity, income, and education levels. Children and older adults had better-quality diets than younger and middle-aged adults; women had better-quality diets than men; Hispanics had better-quality diets than blacks and whites; and diet quality of adults, but not children, generally improved with income level, except for sodium. The diets of Americans, regardless of socioeconomic status, are far from optimal. Problematic dietary patterns were found among all sociodemographic groups. Major improvements in the nutritional health of the American public can be made by improving eating patterns.

  6. Attitudes toward healthy eating: a mediator of the educational level-diet relationship.

    Science.gov (United States)

    Lê, J; Dallongeville, J; Wagner, A; Arveiler, D; Haas, B; Cottel, D; Simon, C; Dauchet, L

    2013-08-01

    A higher educational level is associated with a healthier diet. The goal of this study was to establish whether this association is mediated by attitudes toward healthy eating. The cross-sectional MONA LISA-NUT study was performed in 2005-2007 on adults aged 35-64 years from northern and north-eastern France. Diet quality was assessed on the basis of a 3-day food record and a validated score based on French national dietary guidelines. Specific questions investigated attitudes toward healthy eating. Multivariate analyses were used to quantify the proportion of the educational level-diet relationship that was mediated by attitudes toward healthy eating. Among the 1631 subjects, favourable attitudes toward healthy eating were associated with both higher educational level and diet quality. In the mediation analysis, 'organic food consumption' explained 14% (95% confidence interval (8;24)) of the educational level-diet relationship and 'attention paid to health when buying food' explained 9% (3;16). In contrast, 'attention to food choice', 'searching for information about food' and 'perceived role of eating' were not mediators of the association between educational level and diet. In a multivariate model, the attitude items together accounted for 25% (10;45) of the relationship. The mediation was more pronounced in women than in men (37% (15;54) vs 16% (1;27), respectively) and was significant for consumption of fruits and vegetables (23% (13;37)), whole-grain food (32% (15;58)) and seafood (22% (9;55)). Our results suggest that poor attitudes toward healthy eating in groups with low socioeconomic status constitute an additional factor (along with cost constraints) in the choice of unhealthy foods.

  7. Mixed Messages: Discourses of Education in Policy Speeches to the Japanese Diet

    Science.gov (United States)

    Rear, David

    2011-01-01

    This paper will examine how Japanese education policy was articulated discursively from 1996 to 2010 in the semi-annual speeches of prime ministers to the Diet. It will identify three distinct discourses within these policy statements: a progressive discourse emphasizing the rights of individuals; a neo-liberal discourse of social independence and…

  8. Picometer-Resolution MEMS Segmented DM Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Microelectromechanical systems (MEMS) technology has the potential to create deformable mirrors (DM) with 10^4 actuators that have size, weight, and power...

  9. Picometer-Resolution MEMS Segmented DM Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Microelectromechanical systems (MEMS) technology has the potential to create deformable mirrors (DM) with 10^4 actuators that have size, weight, and power...

  10. Veganism Is a Viable Alternative to Conventional Diet Therapy for Improving Blood Lipids and Glycemic Control.

    Science.gov (United States)

    Trepanowski, John F; Varady, Krista A

    2015-01-01

    The American Diabetes Association (ADA) and the National Cholesterol Education Program (NCEP) have each outlined a set of dietary recommendations aimed at improving glycemic control and blood lipids, respectively. However, traditional vegan diets (low-fat diets that proscribe animal product consumption) are also effective at improving glycemic control, and dietary portfolios (vegan diets that contain prescribed amounts of plant sterols, viscous fibers, soy protein, and nuts) are also effective at improving blood lipids. The purpose of this review was to compare the effects of traditional vegan diets and dietary portfolios with ADA and NCEP diets on body weight, blood lipids, blood pressure, and glycemic control. The main findings are that traditional vegan diets appear to improve glycemic control better than ADA diets in individuals with type 2 diabetes mellitus (T2DM), while dietary portfolios have been consistently shown to improve blood lipids better than NCEP diets in hypercholesterolemic individuals.

  11. Thermodynamics of diffusive DM/DE systems

    Science.gov (United States)

    Haba, Z.

    2017-04-01

    We discuss the energy density, temperature and entropy of dark matter (DM) and dark energy (DE) as functions of the scale factor a in an expanding universe. In a model of non-interacting dark components we repeat a derivation from thermodynamics of the well-known relations between the energy density, entropy and temperature. In particular, the entropy is constant as a consequence of the energy conservation. We consider a model of a DM/DE interaction where the DM energy density increase is proportional to the particle density. In such a model the dependence of the energy density and the temperature on the scale factor a is substantially modified. We discuss (as a realization of the model) DM which consists of relativistic particles diffusing in an environment of DE. The energy gained by the dark matter comes from a cosmological fluid with a negative pressure. We define the entropy and free energy of such a non-equilibrium system. We show that during the universe evolution the entropy of DM is increasing whereas the entropy of DE is decreasing. The total entropy can increase (in spite of the energy conservation) as the DM and DE temperatures are different. We discuss non-equilibrium thermodynamics on the basis of the notion of the relative entropy.

  12. Investigating diet and physical activity in Malaysia: education and family history of diabetes relate to lower levels of physical activity

    National Research Council Canada - National Science Library

    Tam, Cai Lian; Bonn, Gregory; Yeoh, Si Han; Wong, Chee Piau

    2014-01-01

    .... Knowledge of diabetes, health locus of control, diet and exercise habits, as well as family history, education level and other demographic factors to better understand the correlates of risky and healthy behaviors...

  13. Consequences of DM/antiDM oscillations for asymmetric WIMP darkmatter

    DEFF Research Database (Denmark)

    Cirelli, M.; Panci, P.; Servant, G.

    2012-01-01

    Assuming the existence of a primordial asymmetry in the dark sector, a scenario usually dubbed Asymmetric Dark Matter (aDM), we study the effect of oscillations between dark matter and its antiparticle on the re-equilibration of the initial asymmetry before freeze-out, which enable efficient...... a primordial asymmetry of the same order as the baryon asymmetry naturally gets the correct relic abundance if the DM-number-violating Delta(DM) = 2 mass term is in the similar to meV range. The re-establishment of annihilations implies that constraints from the accumulation of aDM in astrophysical bodies...

  14. Consequences of DM/antiDM oscillations for asymmetric WIMP darkmatter

    DEFF Research Database (Denmark)

    Cirelli, M.; Panci, P.; Servant, G.;

    2012-01-01

    Assuming the existence of a primordial asymmetry in the dark sector, a scenario usually dubbed Asymmetric Dark Matter (aDM), we study the effect of oscillations between dark matter and its antiparticle on the re-equilibration of the initial asymmetry before freeze-out, which enable efficient...... annihilations to recouple. We calculate the evolution of the DM relic abundance and show how oscillations re-open the parameter space of aDM models, in particular in the direction of allowing large (WIMP-scale) DM masses. A typical WIMP with a mass at the EW scale (similar to 100 GeV - 1TeV) presenting...

  15. [Improving diet quality in children through a new nutritional education programme: INFADIMED].

    Science.gov (United States)

    Bibiloni, Maria Del Mar; Fernández-Blanco, Jordi; Pujol-Plana, Noemí; Martín-Galindo, Núria; Fernández-Vallejo, Maria Mercè; Roca-Domingo, Mariona; Chamorro-Medina, Juan; Tur, Josep A

    2017-04-11

    To assess the results of a nutritional education programme developed by using available local resources to improve diet quality and decrease overweight and obesity prevalence among children. A longitudinal intervention study by means of nutritional education (INFADIMED) in children (aged 3-7 years) from Vilafranca del Penedès (Barcelona, Spain), recruited from preschool centres and primary schools, with an intervention or INFADIMED group (n=319; 50.2% female) and a control group (n=880; 49.8% female). Weight, height and body mass index were measured in both groups at the beginning and at the end of the programme. Adherence to the Mediterranean diet was also assessed using the KIDMED test. Consumption of fruit or juices, vegetables, yogurt and/or cheese, pasta or rice, and nuts increased, while skipping breakfast, consumption of bakery products for breakfast, and/or consumption of sweets several times per day decreased in the INFADIMED group. INFADIMED also changed, from the beginning to the end of the study, the adherence to a Mediterranean diet: high (39.2% to 70.5%), acceptable (49.2% to 28.2%), and low (11.6% to 1.3%). Approximately 2.6% of the participants in the control group and 11.3% of the participants in the INFADIMED group who were overweight and obese changed to normal weight (odds ratio: 4.08; 95% confidence interval: 2.37-7.04). INFADIMED is a nutritional education programme with benefits on both diet quality and overweight and obesity prevalence among children. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Feasibility of Internet-based Post-secondary Nutrition Education: Incorporating Features of the Mediterranean Diet

    Science.gov (United States)

    Aboul-Enein, Basil H; Bernstein, Joshua

    2015-01-01

    Background: The Internet continues to serve as an ideal venue for health education interventions promoting behavior change. Due to the progressive expansion in online education programs, new methodologies that contribute across health education and program planning continuums are needed. Methods: This ecologic study investigated the change in student dietary behav-ior and food choices following an original online education intervention that introduced the Mediterranean diet (MD) in a community college in Houston, Texas. A non-probability convenience sample (n=65) provided pretest-posttest data measuring knowledge of and attitudes toward the MD. The intervention was incorporated into an undergraduate nutrition course, delivered entirely online and evaluated using the Mediterranean Diet Quality Index (KIDMED) survey. Results: The intervention improved total participant population from a mean KIDMED score of poor (4.12) to a mean score of high (8.45) indicating an increase in knowledge of MD dietary guidelines and a positive shift in favorable attitude, particularly among men. Conclusion: This study provides a unique pedagogical illustration of online learn-ing that introduce a specific evidence-based dietary guideline to a college student population. A detailed discussion of findings and lessons learned is provided. PMID:26290824

  17. Effects of maternal education on diet, anemia, and iron deficiency in Korean school-aged children

    Directory of Open Access Journals (Sweden)

    Choi Hyeon-Jeong

    2011-11-01

    Full Text Available Abstract Background We investigated the relationship among socioeconomic status factors, the risk of anemia, and iron deficiency among school-aged children in Korea. Methods The sample consisted of fourth-grade students aged 10 y recruited from nine elementary schools in Korean urban areas in 2008 (n = 717. Anthropometric and blood biochemistry data were obtained for this cross-sectional observational study. Anemia was defined as hemoglobin levels lower than 11.5 g/dl. Iron deficiency was defined as serum iron levels lower than 40 ug/dl. We also obtained data on parental education from questionnaires and on children's diets from 3-day food diaries. Parental education was categorized as low or high, with the latter representing an educational level beyond high school. Results Children with more educated mothers were less likely to develop anemia (P = 0.0324 and iron deficiency (P = 0.0577 than were those with less educated mothers. This group consumed more protein (P = 0.0004 and iron (P = 0.0012 from animal sources than did the children of less educated mothers, as reflected by their greater consumption of meat, poultry, and derivatives (P Conclusions As a contributor to socioeconomic status, maternal education is important in reducing the risk of anemia and iron deficiency and in increasing children's consumption of animal food sources.

  18. Does a Nutrition Education Programme Change the Knowledge and Practice of Healthy Diets among High School Adolescents in Chennai, India?

    Science.gov (United States)

    Rani, M. Anitha; Shriraam, Vanishree; Zachariah, Rony; Harries, Anthony D.; Satyanarayana, Srinath; Tetali, Shailaja; Anchala, Raghupathy; Muthukumar, Diviya; Sathiyasekaran, B. W. C.

    2013-01-01

    Background: Nutrition education is used as a way of promoting lifelong healthy eating practices among school adolescents. There is limited published information on the impact of nutrition education programmes in India. Objectives: To assess the knowledge and practices of high school students with respect to healthy diets before and after a…

  19. TI DM270 PMP解决方案

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ TI PMP特点 TI提供系列PMP解决方案,包括TI DM270/DM275/DM320/DM342/DM420等数字媒体处理器及不同操作系统(linux或wince等)的PMP方案.另外特别值得关注的是微软公司和TI合作推出了PMC(便携式媒体中心)-Ⅱ代.

  20. Identification of 13 DB + dM and 2 DC + dM binaries from the Sloan Digital Sky Survey

    NARCIS (Netherlands)

    Besselaar, E.J.M. van den; Roelofs, G.H.A.; Nelemans, G.A.; Augusteijn, T.; Groot, P.J.

    2005-01-01

    We present the identification of 13 DB + dM binaries and 2 DC + dM binaries from the Sloan Digital Sky Survey (SDSS). Before the SDSS only 2 DB + dM binaries and 1 DC + dM binary were known. At least three, possibly 8, of the new DB + dM binaries seem to have white dwarf temperatures well above 30 0

  1. A Novel Induction Algorithm for DM

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    DM usually means an efficient knowledge discovery from database, and the immune algorithm is a biological theory-based and global searching algorithm. A novel induction algorithm is proposed here which integrates a power of individual immunity and an evolutionary mechanism of population. This algorithm does not take great care of discovering some classifying information, but unknown knowledge or a predication on higher level rules. Theoretical analysis and simulations both show that this algorithm is prone to the stabilization of a population and the improvement of entire capability, and also keeping a high degree of preciseness during the rule induction.

  2. SELF MANAGEMENT INTERVENTION INCREASING COMPLIANCE IN PATIENT WITH DM

    Directory of Open Access Journals (Sweden)

    Siti Nur Kholifah

    2017-01-01

    Full Text Available Introduction: Diabetes mellitus (DM was a degenerative disease which often found in the community. Diabetes was caused by unhealthy habits, such as overeating, lack of exercise, and stress. The purpose of this study was to identify selfmanagement as one of the interventions that can improve treatment compliance in patients with diabetes. Method: This study was used quasy experiments non randomized pretest-posttest design. Samples were 20 families who lived with type 2 diabetes patient. Variable independent was self management intervention and variable dependent was patient complience. Data were collected by using interview, food recall, and observation on behavioral change. Data then analyzed by using paired t-test with α≤0.05. Results: The results had showed that before intervention only 3 (15 % respondents who obey diabetes diet, then increase to 19 (95 % respondents after intervention with p value=0.000. Patient’s medication compliance also increased, from 6 (30 % respondents before intervention to 20 (100% respondents after intervention, with p value= 0.000. Patient compliance on exercise also increase from 2 (10% respondents before intervention, become 19 (95% respondents after intervention, with p value=0.000. Discussion: Self management intervention could improve patient’s knowledge, problem-solving skills, and self-effi cacy. Self management should be done after the patient had understand their disease and realized the importance of self-care. Community health nurses were expected to implement self management as one of nursing intervention, so that patient compliance on their treatment can be increased. Key words: Self management intervention, compliance, patient DM type 2

  3. Diet and Body Composition Outcomes of an Environmental and Educational Intervention among Men in Treatment for Substance Addiction

    Science.gov (United States)

    Cowan, Jennifer A.; Devine, Carol M.

    2013-01-01

    Objective: To determine the effect of an educational and environmental intervention on diet, body mass index, and waist circumference of men in substance addiction treatment. Methods: One hundred three racially/ethnically diverse men in 6 urban substance addiction residential treatment facilities in Upstate New York participated in weekly…

  4. 仿真食物模型在糖尿病患者饮食教育中的应用%Application of Food Simulation Model in Diet Education for Diabetes Patients

    Institute of Scientific and Technical Information of China (English)

    王丽; 施冠华; 金娟; 郭贝清; 朱俊; 韩梦雨

    2011-01-01

    目的 探讨运用仿真食物模型对糖尿病(Diabetes mellitus,DM)患者进行饮食教育(Diabetes health eduea-tion,DHE)的效果.方法 将符合条件的已确诊的206例住院糖尿病患者随机分为实验组(103例)和对照组(103例).对照组在住院期间给予常规的饮食教育和出院指导,实验组采用常规方法 加仿真食物模型进行相同内容的教育,通过饮食知识测试及空腹血糖(Fasting plasma glucose,FPG)、早餐后2小时血糖(Postprandial two-hour blood glucose,PBG)、糖化血红蛋白(Hemoglobin Alc,HbAlc)、甘油三酯(Triglyceride,TG)、胆固醇(Total cholesterol,TC)、体重指数(Body mass in-dex,BMI)监测观察教育效果.结果 两组患者教育前后各种监测指标均有下降,试验组明显优于对照组且差异有统计学意义(P<0.05);糖尿病饮食知识测试得分分别为35~87分(平均65分)、78~94分(平均90分),差异有统计学意义(P<0.01).结论 利用仿真食物模型对糖尿病患者进行饮食教育有利于患者掌握饮食控制的原则和方法 ,达到更好地控制糖尿病的目的 .%Objective To explore the effect of application of the food simulation model for diet education in diabetes patients.Methods A total of 206 diabetes patients were randomly divided into experimental group given food simulation model as the pattern of diet education and control group given traditional health education ,while all cases were carried out diabetic diet education on same content. Then effects of health education of were observed by testing related diet knowledge and measuring their fasting plasma glucose ( FBG), postprandial two-hour blood glucose ( PBG ), glycosylated hemoglobin ( HbA1c ), Triglyceride ( TG ), total cholesterol(TC) ,body mass index(BMI). Results All related monitoring indexes were decreased in both groups after diet education, but the drops in the experimental group were larger than those in control group ( P < 0.05 ). The score of related

  5. Implementation of SMV based on DM642%基于DM642的SMV实现

    Institute of Scientific and Technical Information of China (English)

    王小兵; 黄冰; 胡巍; 胡斌

    2010-01-01

    介绍了变速率语音算法SMV的DSP实时实现技术.根据标准SMV的要求优化算法的定点C程序,减少占用空间,改善码本的搜索时间,最终在DM642硬件开发平台上运行成功,话音质量符合通信要求.

  6. Awareness and Perception of Plant-Based Diets for the Treatment and Management of Type 2 Diabetes in a Community Education Clinic: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Vincent Lee

    2015-01-01

    Full Text Available Objective. To assess awareness, barriers, and promoters of plant-based diet use for management of type 2 diabetes (T2D for the development of an appropriate educational program. Design. Cross-sectional study of patients and healthcare providers. Setting. Regional Diabetes Education Centre in ON, Canada. Participants. n=98 patients attending the Diabetes Education Centre and n=25 healthcare providers. Variables Measures. Patient questionnaires addressed demographics, health history, and eating patterns, as well as current knowledge, confidence levels, barriers to, promoters of, and interests in plant-based diets. Staff questionnaires addressed attitudes and current practice with respect to plant-based diets. Analysis. Mean values, frequency counts, and logistic regression (alpha = 0.05. Results. Few respondents (9% currently followed a plant-based diet, but 66% indicated willingness to follow one for 3 weeks. Family eating preferences and meal planning skills were common barriers to diet change. 72% of healthcare providers reported knowledge of plant-based diets for diabetes management but low levels of practice. Conclusions and Implications. Patient awareness of the benefits of a plant-based diet for the management of diabetes remains suboptimal and may be influenced by perception of diabetes educators and clinicians. Given the reported willingness to try (but low current use of plant-based diets, educational interventions targeting patient and provider level knowledge are warranted.

  7. Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.

    Science.gov (United States)

    Alvaro-Benito, Miguel; Morrison, Eliot; Wieczorek, Marek; Sticht, Jana; Freund, Christian

    2016-08-01

    Classical MHC class II (MHCII) proteins present peptides for CD4(+) T-cell surveillance and are by far the most prominent risk factor for a number of autoimmune disorders. To date, many studies have shown that this link between particular MHCII alleles and disease depends on the MHCII's particular ability to bind and present certain peptides in specific physiological contexts. However, less attention has been paid to the non-classical MHCII molecule human leucocyte antigen-DM, which catalyses peptide exchange on classical MHCII proteins acting as a peptide editor. DM function impacts the presentation of both antigenic peptides in the periphery and key self-peptides during T-cell development in the thymus. In this way, DM activity directly influences the response to pathogens, as well as mechanisms of self-tolerance acquisition. While decreased DM editing of particular MHCII proteins has been proposed to be related to autoimmune disorders, no experimental evidence for different DM catalytic properties had been reported until recently. Biochemical and structural investigations, together with new animal models of loss of DM activity, have provided an attractive foundation for identifying different catalytic efficiencies for DM allotypes. Here, we revisit the current knowledge of DM function and discuss how DM function may impart autoimmunity at the organism level.

  8. Evaluation of the Perception of the Children and Knowledge of the Educators on Buccal Health, Diet and Hygiene

    Directory of Open Access Journals (Sweden)

    Leonardo dos Santos ANTUNES

    2006-04-01

    Full Text Available Objective: The purpose was to evaluate the level of perception and knowledge on buccal health, diet and hygiene in children and educators of a public school of Niterói-Rio de Janeiro. Method: The sample constituted by 60 children (4 7 years subdivided in two groups of analysis (G1- 4 to 5 years and G2- 6 to 7 years and 25 teachers. For collection of the data two forms had been used (F1- children and F2- educators; F1 contain figures of the food and hygiene resources, while F2 presented questions regarding buccal health, diet and hygiene. The data had been tabulated and analyzed (SPSS 11.0. Results: It was identified that only 24% of the educators presented knowledge necessary on hygienic cleaning to guide parents and children. Although 76% know the importance of foods for teeth, 47.36% didn´t know what kind of food were more healthful (p < 0.05. About the children, 83.3% of G1 and 93.3% of G2 had perceived the importance of the hygiene for teeth, and only 13.3% of G1 and 16.7% of G2 had even so recognized the diet as a representative factor for the buccal health. Conclusion: The authors concluded that even so the majority of the children perceives the importance of the buccal hygiene, these do not recognize the paper of the diet for the maintenance of the health, what it comes to the meeting of the lack of preparation of the educators to guide them, having the necessity of bigger integration school-dentist through lectures and instructions.

  9. Investigating diet and physical activity in Malaysia: education and family history of diabetes relate to lower levels of physical activity

    OpenAIRE

    Tam, Cai Lian; Bonn, Gregory; Yeoh, Si Han; Wong, Chee Piau

    2014-01-01

    The National Health and Morbidity Survey (NHMS, 2011), estimates that the number of Malaysian adults suffering from type 2 diabetes has increased from 8.3 to 31.2% since 1996. This study is a preliminary investigation of possible factors contributing to this epidemic. Knowledge of diabetes, health locus of control, diet and exercise habits, as well as family history, education level and other demographic factors to better understand the correlates of risky and healthy behaviors. This was done...

  10. Investigating diet and physical activity in Malaysia: Education and family history of diabetes relate to lower levels of physical activity

    OpenAIRE

    Cai Lian eTam; Gregory eBonn; Si Han eYeoh; Chee Piau eWong

    2014-01-01

    The National Health and Morbidity Survey (NHMS, 2011), estimates that the number of Malaysian adults suffering from type 2 diabetes has increased from 8.3% to 31.2% since 1996. This study is a preliminary investigation of possible factors contributing to this epidemic. Knowledge of diabetes, health locus of control, diet and exercise habits, as well as family history, education level and other demographic factors to better understand the correlates of risky and healthy behaviours. This was do...

  11. [Quality of the diet "before and during" a weight loss treatment based on Mediterranean Diet; behavioural therapy and nutritional education].

    Science.gov (United States)

    Morales-Falo, Eva María; Sánchez-Moreno, Carmen; Esteban, Alberto; Alburquerque, Juan José; Garaulet, Marta

    2013-01-01

    Introducción: El método de pérdida de peso (dieta mediterránea, terapia de comportamiento y educación nutricional) ha mostrado ser efectivo en el tratamiento de la obesidad. Objetivo: El objetivo del presente trabajo es evaluar y comparar la calidad de las dietas ingeridas antes y durante el tratamiento mediante el Índice de Alimentación Saludable (IAS) y su relación con diferentes variables. Materiales y métodos: La muestra fue de 392 pacientes (330 mujeres, 62 hombres), edad 39,3 ± 11,5 años y IMC de 31,2 ± 5,3 kg/m2. A partir del recuerdo-24 h previo al tratamiento y del registro dietético 7 días se estimó el IAS de “antes” y “durante” tratamiento. El IAS consta de 10 variables que representan el cumplimiento de objetivos nutricionales para la población española (SENC, 2004). Resultados: Dieta previa, presentó un IAS “necesita mejorar” (68,6 ± 11,6) con lípidos (%) (43,9 ± 8,4) y AGS (% lípidos) (67,4 ± 20,1) elevados, además el contenido en AGM (% lípidos) (27,8 ± 15,1) fue insuficiente. El IAS varió en función del IMC siendo el de obesos inferior al de personas con sobrepeso (65,1 ± 11,6 vs 69, 2 ± 13,9; P dieta ingerida durante el tratamiento mejoró notablemente IAS (91,4 ± 9,7). El IAS de las mujeres fue superior (92,3 ± 9,1) al de los hombres (84,4 ± 12,0) (P dieta estudiada durante el tratamiento de pérdida de peso mejoró significativamente en relación a la dieta habitual del paciente. El IAS de la dieta durante el tratamiento se asocia con el sexo, el estado ponderal (sobrepeso y obesidad) y con el éxito del tratamiento (> 5% de pérdida del peso inicial).

  12. Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2.

    Science.gov (United States)

    Vihola, Anna; Bachinski, Linda L; Sirito, Mario; Olufemi, Shodimu-Emmanuel; Hajibashi, Shohrae; Baggerly, Keith A; Raheem, Olayinka; Haapasalo, Hannu; Suominen, Tiina; Holmlund-Hampf, Jeanette; Paetau, Anders; Cardani, Rosanna; Meola, Giovanni; Kalimo, Hannu; Edström, Lars; Krahe, Ralf; Udd, Bjarne

    2010-04-01

    Aberrant transcription and mRNA processing of multiple genes due to RNA-mediated toxic gain-of-function has been suggested to cause the complex phenotype in myotonic dystrophies type 1 and 2 (DM1 and DM2). However, the molecular basis of muscle weakness and wasting and the different pattern of muscle involvement in DM1 and DM2 are not well understood. We have analyzed the mRNA expression of genes encoding muscle-specific proteins and transcription factors by microarray profiling and studied selected genes for abnormal splicing. A subset of the abnormally regulated genes was further analyzed at the protein level. TNNT3 and LDB3 showed abnormal splicing with significant differences in proportions between DM2 and DM1. The differential abnormal splicing patterns for TNNT3 and LDB3 appeared more pronounced in DM2 relative to DM1 and are among the first molecular differences reported between the two diseases. In addition to these specific differences, the majority of the analyzed genes showed an overall increased expression at the mRNA level. In particular, there was a more global abnormality of all different myosin isoforms in both DM1 and DM2 with increased transcript levels and a differential pattern of protein expression. Atrophic fibers in DM2 patients expressed only the fast myosin isoform, while in DM1 patients they co-expressed fast and slow isoforms. However, there was no increase of total myosin protein levels, suggesting that aberrant protein translation and/or turnover may also be involved.

  13. Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2

    OpenAIRE

    2010-01-01

    Aberrant transcription and mRNA processing of multiple genes due to RNA-mediated toxic gain-of-function has been suggested to cause the complex phenotype in myotonic dystrophies type 1 and 2 (DM1 and DM2). However, the molecular basis of muscle weakness and wasting and the different pattern of muscle involvement in DM1 and DM2 are not well understood. We have analyzed the mRNA expression of genes encoding muscle-specific proteins and transcription factors by microarray profiling and studied s...

  14. Healthy education of diabetes admitted into hospital%住院糖尿病患者的健康教育

    Institute of Scientific and Technical Information of China (English)

    孔素琴; 徐秀芳

    2003-01-01

    @@ HEALTHY EDUCATION METHOD The subject is population and population guide is performed.Healthy education was given to patients every week and prevention, treatment nutrient,parmacy and notice items of DM were instructed to the patients.Through blackboard,wallpaper,prevention manual of DM, the patients were told to control blood glucose by adjusting diet.Education direction were aimed at individuals.According to conditions,educational levels,sex,age and familial status,the nurses communicated with the patients and carefully answer their questions to receive confidence,understanding and support and promote confidence of defeat diseases.

  15. A social marketing theory-based diet-education program for women ages 54 to 83 years improved dietary status.

    Science.gov (United States)

    Francis, Sarah L; Taylor, Martha L

    2009-12-01

    Social Marketing Theory is a comprehensive approach of program development encompassing the needs and preferences of the intended audience. It was hypothesized a Social Marketing Theory-based, registered dietitian-led, in-home, cardiovascular disease-targeted diet-education program would improve the dietary status of community-residing older women. Using a randomized control group design, this 90-day program in two North Carolina counties included 58 women (30 control; 28 intervention) ages 54 to 83 years. Data were collected using the Mini Nutritional Assessment, three 3-day food records, and program evaluations. The intervention group received two individual registered dietitian-led in-home education sessions and the control group received education material mailings (Visits 2 and 3). Pretested education materials were used. Visits/mailings were scheduled 28 to 30 days apart. Variables measured included cardiovascular disease-related dietary practices and dietary status (Mini Nutritional Assessment). Data were analyzed using descriptive statistics, paired sample t tests, multivariant analyses, and independent t tests. Intervention and control Mini Nutritional Assessment scores improved (P=0.0001). Intervention subjects consumed more fiber than control (P=0.013) and reduced sodium intake (P=0.02). Controls reduced energy (P=0.01) and cholesterol intakes (P=0.029), likely because of the decreased food intake. The majority (n=51, 87.9%) rated the program as good to excellent and almost all (n=55, 94.8%) would recommend the program to a friend. The most popular features of the program were the individualized sessions (n=20, 34.5%) and diet analyses (n=11, 19%). These results suggest that cardiovascular disease diet-education materials utilizing Social Marketing Theory principles can lead to improved dietary status among community-residing older women.

  16. EW scale DM models with dark gauge symmetries

    CERN Document Server

    Ko, P

    2016-01-01

    In this talk, I describe a class of electroweak (EW) scale dark matter (DM) models where its stability or longevity are the results of underlying dark gauge symmetries: stable due to unbroken local dark gauge symmetry or topology, or long-lived due to the accidental global symmetry of dark gauge theories. Compared with the usual phenomenological dark matter models (including DM EFT or simplified DM models), DM models with local dark gauge symmetries include dark gauge bosons, dark Higgs bosons and sometimes excited dark matter. And dynamics among these fields are completely fixed by local gauge principle. The idea of singlet portals including the Higgs portal can thermalize these hidden sector dark matter very efficiently, so that these DM could be easily thermal DM. I also discuss the limitation of the usual DM effective field theory or simplified DM models without the full SM gauge symmetry, and emphasize the importance of the full SM gauge symmetry and renormalizability especially for collider searches for...

  17. Investigating diet and physical activity in Malaysia: education and family history of diabetes relate to lower levels of physical activity.

    Science.gov (United States)

    Tam, Cai Lian; Bonn, Gregory; Yeoh, Si Han; Wong, Chee Piau

    2014-01-01

    The National Health and Morbidity Survey (NHMS, 2011), estimates that the number of Malaysian adults suffering from type 2 diabetes has increased from 8.3 to 31.2% since 1996. This study is a preliminary investigation of possible factors contributing to this epidemic. Knowledge of diabetes, health locus of control, diet and exercise habits, as well as family history, education level and other demographic factors to better understand the correlates of risky and healthy behaviors. This was done as part of a larger initiative to improve prevention efforts. Questionnaires were completed by 770 individuals from three Malaysian states: Selangor, Penang, and Terengganu. Findings showed that people with better health knowledge and those who have a family history of type 2 diabetes were more likely to have healthy diets. Also, health knowledge related to lower alcohol consumption. Participants with diabetic family members, however, also reported higher levels of stress. Counterintuitively, higher educational levels, higher internal locus of control, better health knowledge, as well as a family history of diabetes all correlated with lower levels of physical activity. Thus, it is suggested that, while increasing health knowledge will be important in addressing the type 2 diabetes epidemic in Malaysia, especially in relation to diet, other cultural factors, specifically norms related to exercise and physical activity, also need to be addressed if the spread of type 2 diabetes is to be addressed over the long term.

  18. Investigating diet and physical activity in Malaysia: Education and family history of diabetes relate to lower levels of physical activity

    Directory of Open Access Journals (Sweden)

    Cai Lian eTam

    2014-12-01

    Full Text Available The National Health and Morbidity Survey (NHMS, 2011, estimates that the number of Malaysian adults suffering from type 2 diabetes has increased from 8.3% to 31.2% since 1996. This study is a preliminary investigation of possible factors contributing to this epidemic. Knowledge of diabetes, health locus of control, diet and exercise habits, as well as family history, education level and other demographic factors to better understand the correlates of risky and healthy behaviours. This was done as part of a larger initiative to improve prevention efforts. Questionnaires were completed by 770 individuals from three Malaysian states: Selangor, Penang, and Terengganu. Findings showed that people with better health knowledge and those who have a family history of type 2 diabetes were more likely to have healthy diets. Also, health knowledge related to lower alcohol consumption. Participants with diabetic family members, however, also reported higher levels of stress. Counterintuitively, higher educational levels, higher internal locus of control, better health knowledge, as well as a family history of diabetes all correlated with lower levels of physical activity. Thus, it is suggested that, while increasing health knowledge will be important in addressing the type 2 diabetes epidemic in Malaysia, especially in relation to diet, other cultural factors, specifically norms related to exercise and physical activity, also need to be addressed if the spread of type 2 diabetes is to be addressed over the long term.

  19. Konfirmasi spesifitas GAD65 terhadap anti-GAD65 pada tikus DM dan pasien DM tipe 1

    Directory of Open Access Journals (Sweden)

    Aulanni’a Aulanni’a

    2012-02-01

    Full Text Available The use of glutamic acid decarboxylase (GAD65 from bovine brain has been studied to obtain basic knowledge and diagnosis and prediction of Type 1 Diabetes Mellitus (DM patients. The importance of GAD65 in DM diagnosis based on its patogenesis. One of the autoimmune marker that can be used to detect beta-pancreas destruction in Diabetes Type I is the antibody to glutamic acid decarboxylase (GAD65. Most of the pre-diabetic patients indicate the reactive autoantibody to GAD65. For early detection of anti-GAD65 in the serum of the patient, human recombinat GAD65 has been succeed to be used. However this is not economical, therefore, it is necessary to find the alternative source of cheaper GAD65. The aim of this research is to develop an early detection kit of Type 1 DM based on antibody- GAD65, since the longest patient suffering from DM has higher probability to be complicated, especially for uncured patients. The anti- GAD65 antibodies induced by anti-GAD65 synthetized and labelled by alkaline phosphatase can be used as reagent detection early DM patients. The ten patients of DM as samples (positive of anti-GAD65 and five rats of DM were positive with western blott technique using reagents as result of this research. It can be concluded, GAD65 enzyme isolated from bovine brain induced anti-GAD65 production and have possibilities to be packaged in a diagnostic kit for patient pre DM.

  20. Bland diet

    Science.gov (United States)

    Heartburn - bland diet; Nausea - bland diet; Diarrhea - bland diet; Peptic ulcer - bland diet ... A bland diet can be used alongside lifestyle changes to help treat ulcers, heartburn, nausea, vomiting, diarrhea, and gas. You may ...

  1. The Influence of Diet and Sport Life-style Interference to the Serum Glucose and Fat Metabolism and Weight of First-diagnosed T2DM Patients%饮食运动等生活方式干预对初发2型糖尿病患者糖脂代谢和体重的影响

    Institute of Scientific and Technical Information of China (English)

    尹群芳; 张秀薇; 陈伟坤; 苏玲君

    2009-01-01

    目的 探讨饮食、运动等生活方式干预对初发2型糖尿病(T2DM)患者糖脂代谢和体重的影响.方法 将85例初发2型糖尿病患者随机分为两组,即干预组和对照组.干预组43例,在药物治疗的同时,对患者进行饮食和运动等生活方式干预治疗;对照组42例,按医嘱应用药物治疗,只做一般的健康教育.两组治疗前后分别检测空腹血浆葡萄糖(FPG)、餐后2 h血糖(PSG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC),检测患者身高、体质量,比较两组代谢指标及其体质指数(body ass index BMI).结果 干预组FPG、PSG、HbA1c、TG、TC、BMI 等水平均显著低于干预前(P<0.01),高密度脂蛋白胆固醇(HDL-C)水平明显提高(P<0.01).对照组FPG、PSG、TG、TC等水平均显著低于干预前(P<0.05);治疗后两组比较FPG、PSG、HbA1c、BMI、TG、TC等差异具有统计学意义(P<0.01,P<0.05).结论 对初发2型糖尿病患者饮食和运动等生活方式干预时间越早,患者糖脂代谢和体质指数改善越明显.

  2. The mediating effect of parents' educational status on the association between adherence to the Mediterranean diet and childhood obesity: the PANACEA study.

    Science.gov (United States)

    Antonogeorgos, George; Panagiotakos, Demosthenes B; Grigoropoulou, Dimitra; Papadimitriou, Anastasios; Anthracopoulos, Michael; Nicolaidou, Polyxeni; Priftis, Kostas N

    2013-06-01

    To investigate the potential mediating effect of parental education on the association between adherence to the Mediterranean diet and obesity, in 10-12 years old children. A cross-sectional survey was performed among 1,125 (529 male) children in Greece. Children and their parents completed standardized questionnaires, which evaluated parents' educational level and dietary habits. Body mass index was calculated and children were classified as normal, overweight or obese (IOTF classification). Adherence to the Mediterranean diet was assessed using the KIDMED score. 27.7% of the children were overweight and 6.3% were obese; 12.3% of children reported high adherence to the Mediterranean diet. Multi-adjusted analysis, stratified by parental education, revealed that adherence to the Mediterranean diet was inversely associated with children's obesity status only in families in which at least one parent was of higher educational level (stratum-specific adjusted odds ratio: 0.41; 95% CI 0.17-0.98), but not those in which both parents were of low educational level. Parental education status seems to play a mediating role in the beneficial effect of Mediterranean diet on children's obesity status.

  3. 绝经后 T2DM 合并 OP 患者饮食及运动管理与糖、骨代谢及骨密度相关性的临床研究%The association among the management of diet and sport, glucose metabolism, bone metabolism, and bone mineral density in postmenopausal women with type II diabetes and osteoporosis:a clinical study

    Institute of Scientific and Technical Information of China (English)

    宋立源; 轩应利; 杨军; 宣淼; 王永兰; 宋利格; 王文杏; 张秀珍

    2014-01-01

    Objective To explore the association among the management of diet and sport, glucose metabolism, bone metabolism, and bone mineral density (BMD) in postmenopausal women with type 2 diabetes mellitus (T2DM) and osteoporosis (OP).Methods A total of 562 postmenopausal women with T2DM and OP were selected and divided into two groups: the manage group (n=278), and the control group (n=284).Subjects in the 2 groups were given strict management and general management, respectively.All the patients took oral medication of glucose-lowering drugs with 600mg/d Caltrate D and 0.25 ug/d calcitriol, simultaneously.At the beginning, the 24th week, and the 48th week of the treatment, the glucose metabolism indexes such as glycosylated hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), and the bone metabolism indexes such as vitamin D3 (VitD3 ), bone alkaline phosphatase (BALP), tartrate-resistant acid phosphatase-5b (TRAP-5b), and serum osteocalcin ( OC) were detected.BMD of different parts were measured using dual-energy X-ray absorptiometry, in order to explore the changes of each index after strict management.Results At the 24th week, HbA1C in the manage group decreased significantly compared to that in the control group, while at the 48th week, the result was even more significant.HbA1C in the manage group was 8.16 ± 1.50%, 7.10 ±1.60%, and 6.01 ±1.59%at the 0, the 24th , and the 48th week, respectively; and HbA1C in the control group was 8.46 ±1.65%, 8.16 ±1.03%, and 8.21 ±1.02%, respectively.The decrease of HbA1C was observed in both manage group and control group, and was much more obvious in the manage group, and the difference between groups was significant (P <0.01).Meanwhile TRAP-5b in the manage group decreased obviously compared to that in the control group, while BALP, VitD3, and OC increased significantly (P<0.01).After 24th week treatment, BMD of the lumbar vertebrae and the femoral neck in the manage group increased gradually, while in the control

  4. Body Image, Dieting and Disordered Eating and Activity Practices among Teacher Trainees: Implications for School-Based Health Education and Obesity Prevention Programs

    Science.gov (United States)

    Yager, Zali; O'Dea, Jennifer

    2009-01-01

    The aim was to investigate and compare body image, body dissatisfaction, dieting, disordered eating, exercise and eating disorders among trainee health education/physical education (H&PE) and non-H&PE teachers. Participants were 502 trainee teachers randomly selected from class groups at three Australian universities who completed the…

  5. Body Image, Dieting and Disordered Eating and Activity Practices among Teacher Trainees: Implications for School-Based Health Education and Obesity Prevention Programs

    Science.gov (United States)

    Yager, Zali; O'Dea, Jennifer

    2009-01-01

    The aim was to investigate and compare body image, body dissatisfaction, dieting, disordered eating, exercise and eating disorders among trainee health education/physical education (H&PE) and non-H&PE teachers. Participants were 502 trainee teachers randomly selected from class groups at three Australian universities who completed the…

  6. Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) & Type 2 Diabetes Mellitus (DM).

    Science.gov (United States)

    Shin, Hyun-Jong; Kim, Jae-Ha; Yi, Joo-Hark; Han, Sang-Woong; Kim, Ho-Jung

    2012-12-01

    We report a rare case of the concurrent manifestation of central diabetes insipidus (CDI) and type 2 diabetes mellitus (DM). A 56 year-old man was diagnosed as a type 2 DM on the basis of hyperglycemia with polyuria and polydipsia at a local clinic two months ago and started an oral hypoglycemic medication, but resulted in no symptomatic improvement at all. Upon admission to the university hospital, the patient's initial fasting blood sugar level was 140 mg/dL, and he showed polydipsic and polyuric conditions more than 8 L urine/day. Despite the hyperglycemia controlled with metformin and diet, his symptoms persisted. Further investigations including water deprivation test confirmed the coexisting CDI of unknown origin, and the patient's symptoms including an intense thirst were markedly improved by desmopressin nasal spray (10 µg/day). The possibility of a common origin of CDI and type 2 DM is raised in a review of the few relevant adult cases in the literature.

  7. DM-Ice: Current Status and Future Prospects

    CERN Document Server

    Pettus, Walter C

    2015-01-01

    DM-Ice is a program towards the first direct detection search for dark matter in the Southern Hemisphere with a 250 kg-scale NaI(Tl) crystal array. It will provide a definitive understanding of the modulation signal reported by DAMA by running an array at both Northern and Southern Hemisphere sites. A 17 kg predecessor, DM-Ice17, was deployed in December 2010 at a depth of 2457 m under the ice at the geographic South Pole and has concluded its 3.5 yr data run. An active R&D program is underway to investigate detectors with lower backgrounds and improved readout electronics; two crystals with 37 kg combined mass are currently operating at the Boulby Underground Laboratory. We report on the final analyses of the DM-Ice17 data and describe progress towards a 250 kg DM-Ice experiment.

  8. Development of three-dimensional memory (3D-M)

    Science.gov (United States)

    Yu, Hong-Yu; Shen, Chen; Jiang, Lingli; Dong, Bin; Zhang, Guobiao

    2016-10-01

    Since the invention of 3-D ROM in 1996, three-dimensional memory (3D-M) has been under development for nearly two decades. In this presentation, we'll review the 3D-M history and compare different 3D-Ms (including 3D-OTP from Matrix Semiconductor, 3D-NAND from Samsung and 3D-XPoint from Intel/Micron).

  9. Scheduling Diet for Diabetes Mellitus Patients using Genetic Algorithm

    Science.gov (United States)

    Syahputra, M. F.; Felicia, V.; Rahmat, R. F.; Budiarto, R.

    2017-01-01

    Diabetes Melitus (DM) is one of metabolic diseases which affects on productivity and lowers the human resources quality. This disease can be controlled by maintaining and regulating balanced and healthy lifestyle especially for daily diet. However, nowadays, there is no system able to help DM patient to get any information of proper diet. Therefore, an approach is required to provide scheduling diet every day in a week with appropriate nutrition for DM patients to help them regulate their daily diet for healing this disease. In this research, we calculate the number of caloric needs using Harris-Benedict equation and propose genetic algorithm for scheduling diet for DM patient. The results show that the greater the number of individuals, the greater the more the possibility of changes in fitness score approaches the best fitness score. Moreover, the greater the created generation, the more the opportunites to obtain best individual with fitness score approaching 0 or equal to 0.

  10. PERBEDAAN POLA KONSUMSI DAN STATUS GIZI ANTARA REMAJA DENGAN ORANG TUA DIABETES MELITUS (DM) DAN NON DM

    OpenAIRE

    Marine, Denov; Adiningsih, Sri

    2017-01-01

    Adolescents prefer to consume high fat and high sugar food compare to healthy food such as fruit and vegetable. High fat and high sugar food are risk factor of diabetes mellitus development, especially in adolescents whose parents had diabetes mellitus. The aim of this study was to analyze the difference of eating habit and nutritional status between adolescents with DM parents and non DM parents. This was a cross-sectional research included 42 adolescents as sample that divided into 21 adole...

  11. The possible importance of income and education as covariates in cohort studies that investigate the relationship between diet and disease.

    Science.gov (United States)

    Temple, Norman

    2015-01-01

      Many cohort studies have been carried out that have provided information on the relationship between diet and health-related outcomes. Omission of important covariates during multivariate analysis may give rise to error due to residual confounding. A possibly important covariate is socioeconomic status (SES) as this is related to both diet and health. To determine the frequency with which different measures of SES are included as covariates during multivariate analysis of cohort studies that investigated the relationship between diet and health.   An analysis was carried out of 76 randomly selected papers from 66 cohort studies. The papers covered many dietary variables and a wide variety of diseases/health-related outcomes. The cohort studies were carried out in many different locations and the subjects varied widely in age.   Approximately two-thirds of the papers (65.8%) used at least one measure of SES as a covariate. Education was used most often (60.5% of papers), followed by income (14.4%) and social class (2.6%). More than one measure of SES was used in 11.8% of papers.   Failure to include income (or another measure of present SES, such as occupation) may be a common source of error in cohort studies. Over-reliance on education may be particularly important as it is likely to be a weaker measure of present SES than is income. There is a need for more research on this question. SES in childhood is almost never included in multivariate analysis in cohort studies carried out on adults. This could also play a significant role in disease risk in middle age or later. Very little is known regarding whether this is also a source of residual confounding.

  12. Diet and Colorectal Cancer Risk: Evaluation of a Nutrition Education Leaflet

    Science.gov (United States)

    Dyer, K. J.; Fearon, K. C. H.; Buckner, K.; Richardson, R. A.

    2005-01-01

    Objective: To evaluate the effect of a needs-based, nutrition education leaflet on nutritional knowledge. Design: Comparison of nutritional knowledge levels before and after exposure to a nutrition education leaflet. Setting: A regional colorectal out-patient clinic in Edinburgh. Method: A nutrition education leaflet, based on an earlier…

  13. IBS Diet

    Science.gov (United States)

    ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ...

  14. File list: Oth.ALL.10.dm.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.ALL.10.dm.AllCell dm3 TFs and others dm All cell types SRX160967,SRX160968,SRX3...35496,SRX495787,SRX495790,SRX495786,SRX335495 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.ALL.10.dm.AllCell.bed ...

  15. File list: Oth.CeL.50.dm.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.CeL.50.dm.AllCell dm3 TFs and others dm Cell line SRX160968,SRX160967,SRX495786...,SRX495787,SRX335495,SRX335496,SRX495790 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.CeL.50.dm.AllCell.bed ...

  16. File list: Oth.CeL.05.dm.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.CeL.05.dm.AllCell dm3 TFs and others dm Cell line SRX160967,SRX495786,SRX160968...,SRX495790,SRX335495,SRX335496,SRX495787 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.CeL.05.dm.AllCell.bed ...

  17. File list: Oth.CeL.10.dm.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.CeL.10.dm.AllCell dm3 TFs and others dm Cell line SRX160967,SRX160968,SRX335496...,SRX495787,SRX495790,SRX495786,SRX335495 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.CeL.10.dm.AllCell.bed ...

  18. History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada

    Directory of Open Access Journals (Sweden)

    J. Phillips

    2012-01-01

    Full Text Available Objectives. Newfoundland and Labrador (NL has one of the highest incidences of Type 1 diabetes mellitus (T1DM worldwide. Rates of T1DM are increasing and the search for environmental factors that may be contributing to this increase is continuing. Methods. This was a population-based case control design involving the linkage of data from a diabetes database with live birth registration data. 266 children aged 0–15 years with T1DM were compared to age- and gender-matched controls. Chi-square analysis and multivariate conditional logistic regression were carried out to assess maternal and infant factors (including maternal age, marital status, education, T1DM, hypertension, birth order, delivery method, gestational age, size-for-gestational-age, and birth weight. Results. Cases of T1DM were more likely to be large-for-gestational-age (P=0.024 and delivered by C-section (P=0.009 as compared to controls. C-section delivery was associated with increased risk of T1DM (HR 1.41, P=0.015 when birth weight and gestational age were included in the model, but not when size-for-gestational-age was included (HR 1.3, P=0.076. Conclusions. Birth by C-section was found to be a risk factor for the development of T1DM in a region with high rates of T1DM and birth by C-section. These findings may have an impact on health practice, health care planning, and future research.

  19. Design Overview of the DM Radio Pathfinder Experiment

    CERN Document Server

    Silva-Feaver, Maximiliano; Cho, Hsiao-Mei; Dawson, Carl; Graham, Peter; Irwin, Kent; Kuenstner, Stephen; Li, Dale; Mardon, Jeremy; Moseley, Harvey; Mule, Richard; Phipps, Arran; Rajendran, Surjeet; Steffen, Zach; Young, Betty

    2016-01-01

    We introduce the DM Radio, a dual search for axion and hidden photon dark matter using a tunable superconducting lumped-element resonator. We discuss the prototype DM Radio Pathfinder experiment, which will probe hidden photons in the 500 peV (100 kHz)-50 neV (10 MHz) mass range. We detail the design of the various components: the LC resonant detector, the resonant frequency tuning procedure, the differential SQUID readout circuit, the shielding, and the cryogenic mounting structure. We present the current status of the pathfinder experiment and illustrate its potential science reach in the context of the larger experimental program.

  20. Electroweak supersymmetric dark matter annihilation in DM rate at NLO

    Energy Technology Data Exchange (ETDEWEB)

    Schmiemann, Saskia; Klasen, Michael; Kovarik, Karol; Steppeler, Patrick [Institut fuer Theoretische Physik, Universitaet Muenster (Germany); Herrmann, Bjoern [LAPTh, Universite Savoie Mont Blanc, CNRS (France); Harz, Julia [CNRS, UMR 7589, LPTHE, Paris (France); Sorbonne Universites, Institut Lagrange de Paris (ILP) (France); Sorbonne Universites, UPMC Univ Paris 06, UMR 7589, LPTHE (France)

    2016-07-01

    Today there are several pieces of evidence for dark matter. One well-known experiment is the measurement of the Dark Matter relic density by the Planck satellite. The talk introduces the 'Dark Matter at next-to-leading order' (DM rate at NLO) project which provides predictions for the dark matter relic density in the MSSM including higher-order corrections. After an introduction of the project DM rate at NLO, I shortly speak about the calculation of the electroweak processes. The main focus lies on the effects of the electroweak tree-level processes on the relic density of neutralinos within selected scenarios.

  1. Design Overview of the DM Radio Pathfinder Experiment

    OpenAIRE

    Silva-Feaver, Maximiliano; Chaudhuri, Saptarshi; Cho, Hsiao-Mei; Dawson, Carl; Graham, Peter; Irwin, Kent; Kuenstner, Stephen; Li, Dale; Mardon, Jeremy; Moseley, Harvey; Mule, Richard; Phipps, Arran; Rajendran, Surjeet; Steffen, Zach; Young, Betty

    2016-01-01

    We introduce the DM Radio, a dual search for axion and hidden photon dark matter using a tunable superconducting lumped-element resonator. We discuss the prototype DM Radio Pathfinder experiment, which will probe hidden photons in the 500 peV (100 kHz)-50 neV (10 MHz) mass range. We detail the design of the various components: the LC resonant detector, the resonant frequency tuning procedure, the differential SQUID readout circuit, the shielding, and the cryogenic mounting structure. We prese...

  2. Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice

    National Research Council Canada - National Science Library

    Rhee, Ki-Jong; Lee, Chang Gun; Kim, Sung Woo; Gim, Dong-Hyeon; Kim, Hyun-Cheol; Jung, Bae Dong

    2015-01-01

    .... In this study, we assessed whether Ginkgo biloba extract (EGb) 761 could provide beneficial effects in the streptozotocin-induced type 1 DM and high-fat diet-induced type 2 DM murine model system...

  3. LikeDM: likelihood calculator of dark matter detection

    CERN Document Server

    Huang, Xiaoyuan; Yuan, Qiang

    2016-01-01

    With the large progresses of searching for dark matter (DM) particles from indirect and direct methods, we develop a numerical tool which enables fast calculation of the likelihood of specified DM particle models given a number of observational data, such as charged cosmic rays from space-borne experiments (e.g., PAMELA, AMS-02), $\\gamma$-rays from Fermi space telescope, and the underground direct detection experiments. The purpose of this tool, \\likedm\\ --- likelihood calculator of dark matter detection, is to bridge the particle model of DM and the observational data. The intermediate steps between these two, including the astrophysical backgrounds, the propagation of charged particles, the analysis of Fermi $\\gamma$-ray data, as well as the DM velocity distribution and the nuclear form factor, have been dealt with in the code. We release the first version (v1.0) focusing on the constraints of charged cosmic and gamma rays and the direct detection part will be implemented in the next version. This manual de...

  4. Antigen list: dm3 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available dm3 TFs and others GFP SRX016140,SRX016156,SRX016162,SRX016166,SRX016170,SRX025466,SRX025470,SRX025476,...SRX030958,SRX030960,SRX030962,SRX030964,SRX032116,SRX032121,SRX032125,SRX033313,SRX03331...5,SRX041381,SRX320155,SRX320156,SRX661230,SRX661232,SRX737176,SRX750072,SRX750083 ...

  5. Analysis of the declared nutritional behaviours in a group of diabetology nurses educating patients about diabetes diet therapy.

    Science.gov (United States)

    Głąbska, Dominika; Włodarek, Dariusz

    2015-01-01

    The proper nutrition in diabetes is one of the crucial elements of therapy, but in practice, diet of diabetic individuals is commonly improperly balanced, that is associated with lack of nutritional knowledge. The nurses are also often characterized by insufficient knowledge about diabetes diet therapy and poor nutritional behaviors. The aim of the study was to analyze of the declared nutritional behaviors in a group of diabetology nurses and to compare it with declared nutritional behaviors of the control group. The group of 52 nurses recruited from all the regions of Poland working with diabetic patients was analysed and compared with control group of 63 individuals - random non-diabetic patients from all the regions of Poland. They were asked about accomplishing practical recommended nutritional goals for adults in Poland and were able to indicate if they follow detailed recommended nutritional goals "always" (3 points), "sometimes" (1 point) or "never" (0 points). The diabetology nurses rarely declared fish and legumes intake (never or sometimes accomplishing goal: 87%), milk and dairy products intake (75%), as well as moderate sugar and sweets intake (69%). Nurses significantly rarer than control group declared regularity of meals (p=0.0000) and diversion of meals (p=0.0000). The lack of correlation between number of years of working with diabetic individuals and number of obtained points during assessment of nutritional behaviors was observed. The nutritional behaviors of diabetology nurses are not good, even if they educate diabetic patients on daily basis. Nutritional education should be conducted not only in groups of diabetic patients, but also, in groups of diabetology nurses.

  6. A Comparison of the impact of family-centered and patient-centered education methods on attitude toward and adherence to diet and fluid restriction in hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Asgari P

    2015-02-01

    Full Text Available Background and Objective: One of the major issues in hemodialysis patients is adherence to diet and fluid restriction. In order to reduce the adverse consequences of the disease and improve quality of life, educating these patients is of great importance. Therefore, the present study was conducted in order to compare the impact of two methods of education (patient-centered and family–centered on attitude toward and adherence to diet and fluid restriction in hemodialysis patients. Materials and Method: This clinical trial was performed on patients referred to the hemodialysis ward of hospitals affiliated with Tehran University of Medical Sciences, Iran, during May to October 2012. Through purposive sampling method, 60 patients were selected and randomly assigned to two groups patient-centered (n = 30 and family-centered (n = 30. Patients’ attitude toward and adherence to diet regime and fluid restriction were assessed using a researcher-made self-report questionnaire in 3 stages (before the intervention, and 2 and 4 weeks after the intervention. The reliability and validity of the questionnaire were approved. Data analysis was performed using SPSS software version 16 and independent t-test, chi-square, Fisher’s exact test, and repeated measures ANOVA. Results: Before the intervention, the findings showed no significant difference between the 2 groups in terms of adherence to diet and fluid restriction. In the second week after the intervention, mean adherence to diet in the family-centered group was significantly higher than the patient-centered group (P = 0.010. Moreover, at the end of the second (P = 0.001 and fourth weeks (P = 0.002, the attitude toward adherence to diet and fluid restriction was more positive in the family-centered group, in comparison to the patient-centered group. Conclusion: Family-centered education is more effective on patient adherence to the treatment regimen. Thus, it is recommended that family

  7. Impact of Mediterranean diet education versus posted leaflet on dietary habits and serum cholesterol in a high risk population for cardiovascular disease

    NARCIS (Netherlands)

    Bemelmans, W.E.; Broer, J.; Vries, de J.H.M.; Hulshof, K.F.A.M.; May, J.F.; Meyboom-de Jong, B.

    2000-01-01

    Objective: To investigate the impact of intensive group education on the Mediterranean diet on dietary intake and serum total cholesterol after 16 and 52 weeks, compared to a posted leaflet with the Dutch nutritional guidelines, in the context of primary prevention of cardiovascular disease (CVD).

  8. Impact of Mediterranean diet education versus posted leaflet on dietary habits and serum cholesterol in a high risk population for cardiovascular disease

    NARCIS (Netherlands)

    Bemelmans, Wanda J. E.; Broer, Jan; de Vries, Jeanne H. M.; Hulshof, Karin F. A. M.; May, Jo F.; Meyboom-de Jong, Betty

    Objective: To investigate the impact of intensive group education on the Mediterranean diet on dietary intake and serum total cholesterol after 16 and 52 weeks, compared to a posted leaflet with the Dutch nutritional guidelines, in the context of primary prevention of cardiovascular disease (CVD).

  9. 国内外饮食教育发展状况分析%Analysis on the Development Status of Domestic and International Diet Education

    Institute of Scientific and Technical Information of China (English)

    生吉萍; 刘丽媛

    2013-01-01

    随着现代科技和农业的进步,人类饮食状况和结构发生改变,人们生活方式疾病迅速蔓延,食品安全事故频频发生,提醒我们需要加大提倡饮食教育的力度.受膳食结构和历史的影响,各个国家的饮食教育有所不同.文章比较了日本、欧盟、美国以及中国饮食教育的发展状况,分析了我国饮食教育的现状并提出建议.%With the progress of high technology and modem agricultural development,human dietary condition and structure are changing,but the food related diseases are spreading rapidly and food safety accidents occurred frequently,so we need to promote diet education.Since each country has different dietary structure,its diet education is different.This paper discussed and compared the difference of diet education status in Japan,Europe,American and China,and we hoped to obtain strageties for China's diet education development.

  10. Impact of Mediterranean diet education versus posted leaflet on dietary habits and serum cholesterol in a high risk population for cardiovascular disease

    NARCIS (Netherlands)

    Bemelmans, W.J.E.; Broer, J.; Vries, J.H.M. de; Hulshof, K.F.A.M.; May, J.F.; Meyboom-de Jong, B.

    2000-01-01

    Objective: To investigate the impact of intensive group education on the Mediterranean diet on dietary intake and serum total cholesterol after 16 and 52 weeks, compared to a posted leaflet with the Dutch nutritional guidelines, in the context of primary prevention of cardiovascular disease (CVD). D

  11. Mediterranean diet as a nutrition education and dietary guide: misconceptions and the neglected role of locally consumed foods and wild green plants.

    Science.gov (United States)

    Manios, Yannis; Detopoulou, Vivian; Visioli, Francesco; Galli, Claudio

    2006-01-01

    In the middle of the previous century the Seven Countries Study first revealed the health benefits of the traditional Cretan diet. The Cretan diet was subsequently used as a basis to form the worldwide known 'Mediterranean diet'. This dietary scheme was visualized as a food pyramid, aimed to constitute a nutrition education tool and guide for the general public and scientific community. However, the way this dietary guide has been perceived by both the public and in certain cases by the scientific community may be oversimplified. From the nutritional point of view, some of the neglected parts of this diet concern the role of locally consumed wild greens, herbs, walnuts, figs and snails, all sources of n-3 fatty acids. The above foods with the addition of fish provide a n-6:n-3 ratio of 2:1 whereas in Northern Europe and the USA the same ratio is 10-20:1. Moreover, the flavonoid and antioxidant content of the traditional Cretan diet may have been underestimated. Despite the increasing knowledge on the bioprotective profile of the traditional Cretan diet, there is a need to revisit the way this knowledge is transferred to the public emphasizing the importance of some neglected food items and nutrients.

  12. The role of diet and exercise in the transgenerational epigenetic landscape of T2DM

    DEFF Research Database (Denmark)

    Barrès, Romain; Zierath, Juleen R

    2016-01-01

    Epigenetic changes are caused by biochemical regulators of gene expression that can be transferred across generations or through cell division. Epigenetic modifications can arise from a variety of environmental exposures including undernutrition, obesity, physical activity, stress and toxins....... Transient epigenetic changes across the entire genome can influence metabolic outcomes and might or might not be heritable. These modifications direct and maintain the cell-type specific gene expression state. Transient epigenetic changes can be driven by DNA methylation and histone modification in response...... to environmental stressors. A detailed understanding of the epigenetic signatures of insulin resistance and the adaptive response to exercise might identify new therapeutic targets that can be further developed to improve insulin sensitivity and prevent obesity. This Review focuses on the current understanding...

  13. Modified DM Models for Aging Networks Based on Neighborhood Connectivity

    Institute of Scientific and Technical Information of China (English)

    WEI Du-Qu; LIN Min; LUO Xiao-Shu; WANG Gang; ZOU Yan-Li; CHEN Tian-Lun

    2008-01-01

    Two modified Dorogovtsev-Mendes (DM) models of aging networks based on the dynamics of connecting nearest-neighbors are introduced. One edge of the new site is connected to the old site with probabilityekt-αas in the DM's model, where the degree and age of the old site are k and t, respectively. We consider two eases, I.e. The other edges of the new site attaching to the nearest-neighbors of the old site with uniform and degree connectivity probability, respectively. The network structure changes with an increase of aging exponent α. It is found that the networks can produce scale-free degree distributions with small-world properties. And the different connectivity probabilities lead to the different properties of the networks.

  14. 社区糖尿病患者饮食健康教育%Diet Health Education of Community Patients with Diabetes

    Institute of Scientific and Technical Information of China (English)

    刘文叶

    2016-01-01

    The diabetes diet education is the key point of health education of diabetes patients, which requires our com-munity medical workers to give scientific diet guidance thus effectively control ling the blood sugar of patients combined with the specific conditions of patients in community practical work.This article begins with the concept of diabetes, ana-lyzes the significance of dietary education for community diabetes patients, and finally focuses on the analysis of the spe-cific methods of diet education and health education for community diabetes patients.%糖尿病饮食教育是糖尿病患者健康教育的重中之重,这就要求我们社区医务工作者在社区实践工作中,结合每个患者的具体情况,因人而异,给予科学的饮食指导,使患者的血糖得到有效控制。该文从糖尿病的概念入手,分析了对社区糖尿病患者进行饮食教育的意义,最后着重分析了对社区糖尿病患者开展饮食教育以及健康教育的具体方法。

  15. Body image, dieting and disordered eating and activity practices among teacher trainees: implications for school-based health education and obesity prevention programs.

    Science.gov (United States)

    Yager, Zali; O'Dea, Jennifer

    2009-06-01

    The aim was to investigate and compare body image, body dissatisfaction, dieting, disordered eating, exercise and eating disorders among trainee health education/physical education (H&PE) and non-H&PE teachers. Participants were 502 trainee teachers randomly selected from class groups at three Australian universities who completed the questionnaire. H&PE males and females had significantly poorer body image and higher levels of body dissatisfaction, dieting and disordered eating behaviors than non-H&PE participants. H&PE teachers were more likely to over-exercise and have exercise disorders, but very few self-identified problems with objectively assessed excessive exercise behaviors. Lifetime prevalence of eating disorders was 12.5% in H&PE males, 0% in non-H&PE males, 7.7% in H&PE females and 6% in non-H&PE females. Few participants had received any past or current treatment. Of particular concern is the likelihood of the teachers' inappropriate and dangerous attitudes and behaviors being intentionally or unintentionally conveyed to their school students. Those planning school health education, nutrition education and school-based obesity prevention programs should provide suitable training for the teachers involved. Screening and treatment services among teachers may also be helpful in order to detect, treat and educate young teachers about body image, dieting, disordered eating and physical activity practices.

  16. Hyperuricaemia and the metabolic syndrome in type 2 DM

    Directory of Open Access Journals (Sweden)

    Ogbera Anthonia O

    2010-04-01

    Full Text Available Abstract Background Elevated serum uric acid levels (SUA have been associated with an increased risk of cardiovascular diseases and the metabolic syndrome (MetS and are often reported to be higher in females than in males. The aim of this report is to determine the prevalence and clinical correlates of hyperuricaemia and also to evaluate associations with the MetS in people with type 2 diabetes mellitus (DM. Methods This was a cross-sectional study conducted in people with type 2 DM in Lagos, Nigeria. Hyperuricaemia was defined by cut-off values of > 7 mg/dl for men and > 6 mg/dl for women. The diagnosis of MetS was made using the new definition by the American Heart Association and other related bodies. Clinical and biochemical parameters were compared between subjects with hyperuricaemia and normouricaemia. Statistical analysis included usage of Student's t test, Pearson correlation coefficients, multivariate regression analysis and chi square. Results 601 patients with type 2 DM aged between 34-91 years were recruited for the study. The prevalence rates of hyperuricaemia and the MetS were 25% and 60% respectively. The frequency of occurrence of hyperuricaemia was comparable in both genders (59% vs 41%, p = 0.3. Although, the prevalence of the MetS in subjects with hyperuricaemia and normouricaemia was comparable (61 vs 56%, p = 0.1, a higher proportion of hyperuricaemic subjects had 3 or more components of the Mets compared with normouricaemic subjects. Possible predictors of hyperuricaemia include central obesity, smoking and elevated serum triglycerides (TG. SUA levels were found to be positively and significantly associated with serum TG (r = 0.2, p = 0.0001 and total cholesterol (r = 13, p = 0.001. Conclusion The prevalence of hyperuricaemia in subjects with type 2 DM is comparable in both genders and possible predictors of hyperuricaemia are potentially modifiable. SUA is positively and significantly associated with serum TG and total

  17. The American Education Diet: Can U.S. Students Survive on Junk Food?

    Science.gov (United States)

    DeSchryver, Dave

    U.S. student scores in science compare unfavorably with those of other nations, and other standardized test scores by U.S. students are also comparatively lower. Polls of parents indicate dissatisfaction with U.S. education. College teachers and employers feel that high school graduates are weak in skills. This document offers negative perceptions…

  18. In vitro mapping of Myotonic Dystrophy (DM) gene promoter

    Energy Technology Data Exchange (ETDEWEB)

    Storbeck, C.J.; Sabourin, L. [Univ. of Ottawa (Canada); Baird, S. [Children`s Hospital of Eastern Ontario, Ottawa (Canada)] [and others

    1994-09-01

    The Myotonic Dystrophy Kinase (DMK) gene has been cloned and shared homology to serine/threonine protein kinases. Overexpression of this gene in stably transfected mouse myoblasts has been shown to inhibit fusion into myotubes while myoblasts stably transfected with an antisense construct show increased fusion potential. These experiments, along with data showing that the DM gene is highly expressed in muscle have highlighted the possibility of DMK being involved in myogenesis. The promoter region of the DM gene lacks a consensus TATA box and CAAT box, but harbours numerous transcription binding sites. Clones containing extended 5{prime} upstream sequences (UPS) of DMK only weakly drive the reporter gene chloramphenicol acetyl transferase (CAT) when transfected into C2C12 mouse myoblasts. However, four E-boxes are present in the first intron of the DM gene and transient assays show increased expression of the CAT gene when the first intron is present downstream of these 5{prime} UPS in an orientation dependent manner. Comparison between mouse and human sequence reveals that the regions in the first intron where the E-boxes are located are highly conserved. The mapping of the promoter and the importance of the first intron in the control of DMK expression will be presented.

  19. A Forming Pair of Dwarf Galaxies and Its DM Halo

    Science.gov (United States)

    Pustilnik, S. A.; Brinks, E.; Thuan, T. X.; Izotov, Yu.; Lipovetsky, V.

    SBS 0335-052 and its companion 0335-052W are shown to be a unique pair of currently forming dwarf galaxies associated with a huge HI cloud (Izotov et al. 1997, Lipovetsky et al. 1997, Thuan et al. 1997, Pustilnik et al. 1997). We present the analysis of the velocity field of this HI cloud, obtained with the VLA, and the model of its rotation curve to derive the total mass distribution in this system. We argue that this gas cloud is rotationally supported in the gravitational potential of a massive DM halo, and discuss the implications of this fact for galaxy formation and evolution scenarios. This unique system apparently preserves the original unperturbed structure of its DM halo and is thus very valuable to confront halo properties with model predictions. The parameters of the DM halo and neutral gas set limits, based on observational evidence, to the range of physical conditions under which a pristine hydrogen cloud can survive as a stable object over cosmlogical time scales. We discuss the possible effect of the massive spiral galaxy at the projected distance of about 100/h kpc to these forming galaxies.

  20. Immune dysfunction in patients with diabetes mellitus (DM).

    Science.gov (United States)

    Geerlings, S E; Hoepelman, A I

    1999-12-01

    Patients with diabetes mellitus (DM) have infections more often than those without DM. The course of the infections is also more complicated in this patient group. One of the possible causes of this increased prevalence of infections is defects in immunity. Besides some decreased cellular responses in vitro, no disturbances in adaptive immunity in diabetic patients have been described. Different disturbances (low complement factor 4, decreased cytokine response after stimulation) in humoral innate immunity have been described in diabetic patients. However, the clinical relevance of these findings is not clear. Concerning cellular innate immunity most studies show decreased functions (chemotaxis, phagocytosis, killing) of diabetic polymorphonuclear cells and diabetic monocytes/macrophages compared to cells of controls. In general, a better regulation of the DM leads to an improvement of these cellular functions. Furthermore, some microorganisms become more virulent in a high glucose environment. Another mechanism which can lead to the increased prevalence of infections in diabetic patients is an increased adherence of microorganisms to diabetic compared to nondiabetic cells. This has been described for Candida albicans. Possibly the carbohydrate composition of the receptor plays a role in this phenomenon.

  1. Is mortalin a candidate gene for T1DM ?

    Science.gov (United States)

    Johannesen, Jesper; Pie, Angeles; Karlsen, Allan Ertmann; Larsen, Zenia Marian; Jensen, Allan; Vissing, Henrik; Kristiansen, Ole Peter; Pociot, Flemming; Nerup, Jørn

    2004-01-01

    Mortalin has been found to be up-regulated by 2D-protein gel analysis in isolated rodent islets exposed to cytokines. In islets from two rat strains with different sensitivity to the toxic effects of cytokines we observed a significant difference in IL-1beta mediated mortalin expression. Constitutive over-expression of rat mortalin in NIH3T3 cells reduced cellular survival in accordance with mortalin being associated to cellular senescence. Hence we consider the gene encoding for mortalin at chromosome 5q31.1 a putative candidate gene in cytokine induced beta-cell destruction. We scanned the human mortalin gene for polymorphisms and identified three novel polymorphisms. Neither the SNPs individually nor as constructed haplotypes showed disease association tested by (E)TDT in a Danish type 1 diabetes (T1DM) population. Furthermore, we tested the D5S500 microsatelite located close to 5q31.1 without finding linkage to (T1DM). In conclusion, the functional data identifying a difference in mortalin expression in IL-1beta stimulated islets between two rat strains and over-expression of mortalin in NIH3T3 cells associated with decreased viability suggests a functional role for mortalin in cytokine mediated beta cell destruction; however, the identified polymorphisms did not reveal any association in the presence of linkage disequilibrium of mortalin to T1DM in the Danish population.

  2. Diet choice in weight-restored patients with eating disorders: progressive autonomy process by nutritional education

    Directory of Open Access Journals (Sweden)

    Inmaculada Ruiz-Prieto

    2013-10-01

    Full Text Available Introduction: Human eating behaviour is regulated by multiple factors. Anorexia nervosa patients show a restrictive eating pattern while bulimia nervosa patients present bingeing-purging episodes. Although treatments are specially successful in the normalization of body composition, maladaptive eating behaviours tend to persist being a risk factor for relapse and recurrence. Objectives: The aim of this work was to assess the quality of the nutritional choice of eating disorders patients after a year of nutritional education and to assess improvements in choice capacity. Methods: Thirty-one outpatients of an eating disorders unit planned a menu after body composition normalization and repeated this plan each three months during a one-year programme of nutritional education. Results: Patients improved the time spent on the assignment (p < 0.01, Body Mass Index (p < 0.01, their body fat mass (p < 0.01 and the content of energy (p < 0.05, carbohydrates (p < 0.01 and polyunsaturated fatty acids (p < 0.05 in their chosen menus. No differences were found on proteins, total fat or fat profile, vitamins or minerals. 12.9% and 3.2% of the patients chose their menu according to the recommendations of caloric and lipid profile, respectively, after a year of nutritional education. Discussion: Although patients improved energy and carbohydrates content of the menus they tended to reduce caloric and fat food choices, which could lead to relapse and recurrence. Specific nutritional education programmes along with the mandatory psychological and psychiatric treatment may be effective. Conclusions: One year of nutritional education combined with psychological and psychiatric treatment improved those factors usually involved in relapse and recurrence, thus contributing to a proper outcome.

  3. Effects of monensin supplementation on ruminal metabolism of feedlot cattle fed diets containing dried distillers grains.

    Science.gov (United States)

    Felix, T L; Pyatt, N A; Loerch, S C

    2012-11-01

    Two experiments were conducted to evaluate the effects of monensin and dried distillers grains with solubles (DDGS) on ruminal metabolism in 8 fistulated steers. In Exp. 1, treatments were (DM basis): 1) 0 mg monensin/kg diet DM, 2) 22 mg monensin/kg diet DM, 3) 33 mg monensin/kg diet DM, and 4) 44 mg monensin/kg diet DM. The remainder of the diet was 10% corn silage, 60% DDGS, 10% corn, and 20% mineral supplement that used ground corn as the carrier. There was no effect (P > 0.80) of dietary monensin inclusion on DMI. Increasing dietary monensin did not affect (P > 0.05) ruminal VFA concentrations or lactic acid concentrations. There was no effect (P > 0.15) of increasing dietary monensin concentration on ruminal hydrogen sulfide gas (H(2)S) and liquid sulfide (S(2-)) concentrations, or ruminal pH. In Exp. 2, treatments were arranged in a 2 × 2 factorial and contained (DM basis): 1) 0 mg monensin/kg diet DM + 25% DDGS inclusion, 2) 0 mg monensin/kg diet DM + 60% DDGS inclusion, 3) 44 mg monensin/kg diet DM + 25% DDGS inclusion, and 4) 44 mg monensin/kg diet DM + 60% DDGS inclusion. The remainder of the diet was 15% corn silage, corn, and 20% mineral supplement that used ground corn as a carrier. With 60% dietary DDGS inclusion, DMI decreased (P diet, 0 h postfeeding acetate concentration was decreased compared with when 60% DDGS was fed (P diets, regardless of monensin inclusion. This increase in propionate concentrations contributed to the increase (P = 0.03) in total VFA concentrations at 3 h postfeeding when 60% DDGS diets were fed. There was no interaction detected (P > 0.05) for H(2)S or S(2-) concentrations in Exp. 2. Feeding 60% DDGS diets increased mean H(2)S by 71% when compared with feeding 25% DDGS diets. Similar to the response observed for H(2)S, feeding 60% DDGS diets increased mean S(2-) by 64% when compared with feeding 25% DDGS diets. Although these studies did not show beneficial effects of monensin supplementation on ruminal pH, VFA, or H(2)S

  4. Perbandingan kadar hs-CRP pada penderita DM tipe 2 yang dislipidemi dan nondislipidemi

    OpenAIRE

    Pasaribu, Juli Y.M

    2016-01-01

    Introduction : DM type 2 is a global health problem which the prevalence is getting more increased. One of the complications DM type 2 is the coronary artery disease (CAD). CAD is caused by the endothelial dysfunction which later becomes atherosclerosis. Besides DM, dyslipidemia might cause the endothelial dysfunction. DM and dyslipidemia, each of them might cause the endothelium dysfunction, furthermore, if it is found that the DM patients suffer dyslipidemia, it will increase the risk of th...

  5. Diet choice in weight-restored patients with eating disorders; progressive autonomy process by nutritional education.

    Science.gov (United States)

    Ruiz-Prieto, Inmaculada; Bolaños-Ríos, Patricia; Jáuregui-Lobera, Ignacio

    2013-01-01

    Introducción: El comportamiento alimentario humano está regulado por numerosos factores. Mientras los pacientes con anorexia nerviosa muestran un patrón nutricional restrictivo, los pacientes con bulimia nerviosa presentan episodios de atracón y purgas. Aunque los tratamientos son muy efectivos en la normalización de la composición corporal los comportamientos alimentarios inadecuados tienden a mantenerse constituyendo un factor de riesgo de recaídas y recidivas. Objetivos: El objetivo de este trabajo fue evaluar la calidad de la elección nutricional de pacientes con trastornos de la conducta alimentaria durante un programa de un año de educación nutricional analizando la mejoría en la capacidad de elección. Método: Treinta y un pacientes de una unidad de trastornos alimentarios planificaron un menú tras la normalización de la composición corporal, tarea que repitieron cada tres meses durante el año de intervención. Resultados: Los pacientes mejoraron el tiempo emplea - do en configurar el menú (p < 0,01), el Índice de Masa Corporal (p < 0,01), la masa grasa corporal (p < 0,01), la energía (p < 0,05), los carbohidratos (p < 0,01) y los ácidos grasos poliinsaturados (p < 0,05) de los menús planificados. No hubo diferencias en cuanto al total de grasas, perfil lipídico, vitaminas y minerales. El 12,9% y 3,2% de los pacientes escogieron sus menús de acuerdo a las recomendaciones de perfil calórico y lipídico, respectivamente, tras el año de tratamiento. Discusión: Aunque los pacientes mejoraron el contenido energético y los carbohidratos en los menús elegidos, tendieron a reducir el contenido calórico y las grasas en su elección, lo que puede conducir a una peor evolución. Conclusiones: Durante un año de educación nutricional, junto con el correspondiente tratamiento psicológico y psiquiátrico, se observó una mejoría en los factores dietéticos habitualmente implicados en una posible mala evolución.

  6. Data Clustering Menggunakan Metodologi CRISP-DM Untuk Pengenalan Pola Proporsi Pelaksanaan Tridharma

    Directory of Open Access Journals (Sweden)

    Irwan Budiman

    2014-01-01

    Full Text Available Quality of human resources faculty can be reflected from the implementation of productivity and quality Tridharma (education, research, community service  and  supporting  field  activities.  Lecturer  Workload  and Evaluation of  Higher Education  Tridharma  (BKD  and theEPT-PT  aims  to  ensure  the  implementation  of  the  faculty  task  runs  according  to  the  criteria  set  out  in  legislation.  Data  clusteringTridharma  implementation is needed to  get  some  knowledge  of the  pattern of Tridharma  implementation  at  college.  Clustering  as a  data mining  technique  should be  scalable, reliable  and  meet  an  agreed  standard.  CRISP-DM is the standardization of  data mining  is  used  in this study. The results of data clustering found the pattern of proportion of Tridharma  into 3 clusters representing patterns: professionals, managers and teachers.Keywords : Clustering, CRISP-DM, K-Means, Tridharma

  7. [Characterization of a thermophilic Geobacillus strain DM-2 degrading hydrocarbons].

    Science.gov (United States)

    Liu, Qing-kun; Wang, Jun; Li, Guo-qiang; Ma, Ting; Liang, Feng-lai; Liu, Ru-lin

    2008-12-01

    A thermophilic Geobacillus strain DM-2 from a deep-subsurface oil reservoir was investigated on its capability of degrading crude oil under various conditions as well as its characters on degrading hydrocarbons in optimal conditions. The results showed that Geobacillus strain DM-2 was able to degrade crude oil under anoxic wide-range conditions with pH ranging from 4.0 to 10.0, high temperature in the range of 45-70 degrees C and saline concentration ranging from 0.2% to 3.0%. Furthermore, the optimal temperature and pH value for utilizing hydrocarbons by the strain were 60 degrees C and 7.0, respectively. Under such optimal conditions, the strain utilized liquid paraffine emulsified by itself as its carbon source for growth; further analysis by gas chromatography (GC) and infrared absorption spectroscopy demonstrated that it was able to degrade n-alkanes (C14-C30), branched-chain alkanes and aromatic hydrocarbons in crude oil and could also utilize long-chain n-alkanes from C16 to C36, among of which the degradation efficiency of C28 was the highest, up to 88.95%. One metabolite of the strain oxidizing alkanes is fatty acid.While utilizing C16 as carbon source for 5 d, only one fatty acid-acetic acid was detected by HPLC and MS as the product, with the amount of 0.312 g/L, which indicated that it degraded n-alkanes with pathway of inferior terminal oxidation,and then followed by a beta-oxidation pathway. Due to its characters of efficient emulsification, high-performance degradation of hydrocarbons and fatty-acid production under high temperature and anoxic condition, the strain DM-2 may be potentially applied to oil-waste treatment and microbial enhanced heavy oil recovery in extreme conditions.

  8. Paleolithic diet

    OpenAIRE

    Malus, Katja

    2014-01-01

    The paleolithic diet is a diet which imitates the nutrition eaten by various species of hominoids living in the paleolithic era by using foodstuffs available today. The objectives of our thesis were to research the nutrition of human ancestors, to describe a modern paleolithic diet and compare it to healthy dietary guidelines and present experience of individuals who were experimentally eating a paleolithic diet. The aim was to determine whether consuming a paleolithic diet could have benefic...

  9. Paleolithic diet

    OpenAIRE

    Malus, Katja

    2014-01-01

    The paleolithic diet is a diet which imitates the nutrition eaten by various species of hominoids living in the paleolithic era by using foodstuffs available today. The objectives of our thesis were to research the nutrition of human ancestors, to describe a modern paleolithic diet and compare it to healthy dietary guidelines and present experience of individuals who were experimentally eating a paleolithic diet. The aim was to determine whether consuming a paleolithic diet could have benefic...

  10. Identifying Bank Frauds Using CRISP-DM and Decision Trees

    Directory of Open Access Journals (Sweden)

    Bruno Carneiro da Rocha

    2010-10-01

    Full Text Available This article aims to evaluate the use of techniques of decision trees, in conjunction with the managementmodel CRISP-DM, to help in the prevention of bank fraud. This article offers a study on decision trees, animportant concept in the field of artificial intelligence. The study is focused on discussing how these treesare able to assist in the decision making process of identifying frauds by the analysis of informationregarding bank transactions. This information is captured with the use of techniques and the CRISP-DMmanagement model of data mining in large operational databases logged from internet banktransactions.

  11. Prospective, randomized trial on intensive SMBG management added value in non-insulin-treated T2DM patients (PRISMA): a study to determine the effect of a structured SMBG intervention.

    Science.gov (United States)

    Scavini, Marina; Bosi, Emanuele; Ceriello, Antonio; Giorgino, Francesco; Porta, Massimo; Tiengo, Antonio; Vespasiani, Giacomo; Bottalico, Davide; Marino, Raffaele; Parkin, Christopher; Bonizzoni, Erminio; Cucinotta, Domenico

    2013-10-01

    Self-monitoring of blood glucose (SMBG) is a core component of diabetes management. However, the International Diabetes Federation recommends that SMBG be performed in a structured manner and that the data are accurately interpreted and used to take appropriate therapeutic actions. We designed a study to evaluate the impact of structured SMBG on glycemic control in non-insulin-treated type 2 diabetes (T2DM) patients. The Prospective, Randomized Trial on Intensive SMBG Management Added Value in Non-insulin-Treated T2DM Patients (PRISMA) is a 12-month, prospective, multicenter, open, parallel group, randomized, and controlled trial to evaluate the added value of an intensive, structured SMBG regimen in T2DM patients treated with oral agents and/or diet. One thousand patients (500 per arm) will be enrolled at 39 clinical sites in Italy. Eligible patients will be randomized to the intensive structured monitoring (ISM) group or the active control (AC) group, with a glycosylated hemoglobin (HbA1c) target of <7.0%. Intervention will comprise (1) structured SMBG (4-point daily glucose profiles on 3 days per week [ISM]; discretionary, unstructured SMBG [AC]); (2) comprehensive patient education (both groups); and (3) clinician's adjustment of diabetes medications using an algorithm targeting SMBG levels, HbA1c and hypoglycemia (ISM) or HbA1c and hypoglycemia (AC). The intervention and trial design build upon previous research by emphasizing appropriate and collaborative use of SMBG by both patients and physicians. Utilization of per protocol and intent-to-treat analyses facilitates assessment of the intervention. Inclusion of multiple dependent variables allows us to assess the broader impact of the intervention, including changes in patient and physician attitudes and behaviors.

  12. Dietary education for university students : Effect of putting the poster related to diet or nutrition in the sign stand on university cafeteria dining tables

    OpenAIRE

    冨永, 美穂子; 濱端, 倫子

    2015-01-01

    We investigated the effectiveness of a university cafeteria as a place of dietary education by putting 10 kinds of poster related to diet or nutrition in the sign stand on the dining tables at a university cafeteria over a period of 10 weeks (1 week for each poster). We conducted a questionnaire survey among students using the cafeteria with respect to such items as requests to the cafeteria, awareness of nutritional balance, frequency of eating breakfast, and utility of the posters i...

  13. Implementing VLPR systems based on TMS320DM642

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper gives a practical schema for using DSP boards to construct Vehicle License Plate Recognition (VLPR) modules that could be embedded in any Intelligent Transportation System (ITS). Using DSP can avoid the heavy investment in dedicated VLPR system and improve the computational power compared to PC software environment. Low cost, high computational power, and high flexibility of DSP provide the License Plate Recognition System (LPRS) an excellent cost-effective solution to execute the major part of the recognition tasks. This paper describes a successful implementation of VLPR system based on Texas Instruments (TI)'s TMS320DM642. The DSP board acquires video (which could be output to a monitor for surveillance)from a camera, captures images from the video, locates and recognizes the license plates in images, and then sends the recognized results and related images after compression to a host PC through the network. Finally, the overall software is optimized according to the features of DM642 chip. Experiments showed that the DSP VLPR system performs well on the local license plates, and that the processing speed and accuracy can meet the requirement of practical applications.

  14. Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

    Directory of Open Access Journals (Sweden)

    Kumar Sudhesh

    2009-04-01

    Full Text Available Abstract Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue. Aims The study investigated the relationship between endotoxin and various metabolic parameters of diabetic patients to determine if anti-diabetic therapies exerted a significant effect on endotoxin levels and adipocytokine profiles. Methods Fasting blood samples were collected from consenting Saudi Arabian patients (BMI: 30.2 ± (SD5.6 kg/m2, n = 413, consisting of non-diabetics (ND: n = 67 and T2DM subjects (n = 346. The diabetics were divided into 5 subgroups based on their 1 year treatment regimes: diet-controlled (n = 36, metformin (n = 141, rosiglitazone (RSG: n = 22, a combined fixed dose of metformin/rosiglitazone (met/RSG n = 100 and insulin (n = 47. Lipid profiles, fasting plasma glucose, insulin, adiponectin, resistin, TNF-α, leptin, C-reactive protein (CRP and endotoxin concentrations were determined. Results Regression analyses revealed significant correlations between endotoxin levels and triglycerides (R2 = 0.42; p 2 = 0.10; p 2 = 0.076; p 2 = 0.032; p 2 = 0.055; p Conclusion We conclude that sub-clinical inflammation in T2DM may, in part, be mediated by circulating endotoxin. Furthermore, that whilst the endotoxin and adipocytokine profiles of diabetic patients treated with different therapies were comparable, the RSG group demonstrated significant differences in both adiponectin and endotoxin levels. We confirm an association between endotoxin and serum insulin and triglycerides and an inverse relationship with HDL. Lower endotoxin and higher adiponectin in the groups treated with RSG may be related and indicate another mechanism for the effect of RSG on insulin sensitivity.

  15. The effect of the addition of resistance training to a dietary education intervention on apolipoproteins and diet quality in overweight and obese older adults

    Directory of Open Access Journals (Sweden)

    Valente EA

    2011-09-01

    Full Text Available Elizabeth A Valente1, Megan E Sheehy1, Joshua J Avila2, Julie A Gutierres2, Matthew J Delmonico2, Ingrid E Lofgren11Department of Nutrition and Food Sciences, 2Department of Kinesiology, University of Rhode Island, Kingston, RI, USAObjectives: The aim of the study was to examine the additive effect of resistance training (RT to a dietary education (DE intervention on emerging coronary heart disease (CHD risk factors, concentration of apolipoproteins B (apoB and A-I (apoA-I, and Dietary Approaches to Stop Hypertension (DASH Diet Index scores in overweight and obese older adults.Patients and methods: This was an ancillary study of a randomized clinical trial held in the Fall of 2008 at the University of Rhode Island. Participants were overweight or obese subjects (mean body mass index [BMI] of 31.7 kg/m2 randomized into two groups, one participating in DE only (n = 12 and the other participating in DE plus RT (DERT (n = 15. The intervention involved all subjects participating in 30 minutes of DE per week for 10 weeks. Subjects in the DERT group participated in an additional 40 minutes of RT three times per week for 10 weeks. Measurements taken were anthropometric (height, weight, waist circumference, and body composition using the BOD POD® [Body Composition System, v 2.14; Life Measurement Instruments, Concord, CA], clinical (blood pressure, and biochemical (lipid profile and apoB and apoA-I concentrations, and the DASH Diet Index was used to measure diet quality.Results: 27 subjects (11 males, 16 females, with a mean age of 66.6 ± 4.3 years, were included in analyses. The DERT subjects had significantly better triacylglycerol and apoB concentrations and DASH Diet Index scores than the DE subjects post-intervention. Improvements were seen within the DE group in energy intake, fat-free mass, and systolic blood pressure and within the DERT group in body weight, percentage of body fat, BMI, diastolic blood pressure, and oxidized low

  16. Aberrant intracellular metabolism of T-DM1 confers T-DM1 resistance in HER2-positive gastric cancer cells.

    Science.gov (United States)

    Wang, Hongbin; Wang, Wenqian; Xu, Yongping; Yang, Yong; Chen, Xiaoyan; Quan, Haitian; Lou, Liguang

    2017-04-07

    T-DM1 (Kadcyla), an antibody-drug conjugate (ADC) consisting of HER2-targeted monoclonal antibody trastuzumab linked to anti-microtubule agent mertansine (DM1), has been approved for the treatment of HER2-positive metastatic breast cancer. To date, acquired resistance arises to be a major obstacle to T-DM1 treatment, and mechanisms remain incompletely understood. In the present study, we established a T-DM1-resistant N87-KR cell line from HER2-positive N87 gastric cancer cells to investigate mechanisms of acquired resistance and develop strategies for overcoming it. Although the kinetics of binding, internalization, and externalization of T-DM1 were the same in N87-KR cells and N87 cells, N87-KR was strongly resistant to T-DM1, but remained sensitive to both trastuzumab and DM1. T-DM1 failed to inhibit microtubule polymerization in N87-KR cells. Consistently, lysine-MCC-DM1, the active T-DM1 metabolite that inhibits microtubule polymerization, accumulated much lesser in N87-KR cells. Furthermore, lysosome acidification, achieved by V-ATPase, was much diminished in N87-KR cells. Notably, treatment of sensitive N87 cells with the V-ATPase-selective inhibitor Baf-A1 induced T-DM1 resistance, suggesting that aberrant V-ATPase activity decreases T-DM1 metabolism, leading to T-DM1 resistance in N87-KR cells. Interestingly, HER2-targeted ADCs containing a protease-cleavable linker, such as hertuzumab-vc-MMAE, were capable of efficiently overcoming this resistance. Our results demonstrate for the first time that a decrease in T-DM1 metabolites induced by aberrant V-ATPase activity contributes to T-DM1 resistance, which could be overcome by HER2-targeted ADC containing different linkers, including a protease-cleavable linker. Accordingly, we propose that V-ATPase activity in lysosomes is a novel biomarker for predicting T-DM1 resistance. This article is protected by copyright. All rights reserved.

  17. Vegetarian Diet

    Science.gov (United States)

    A vegetarian diet focuses on plants for food. These include fruits, vegetables, dried beans and peas, grains, seeds and nuts. There is no single type of vegetarian diet. Instead, vegetarian eating patterns usually fall into ...

  18. Diet & Nutrition

    Science.gov (United States)

    ... Nutrition Share this page Facebook Twitter Email Diet & Nutrition Eating healthy to take charge of your health. Shelly Diagnosed in 2006 Diet & Nutrition Take Control of Your Weight Portion Control Low ...

  19. STT Doubles with Large DM - Part IV: Ophiuchus and Hercules

    Science.gov (United States)

    Knapp, Wilfried; Nanson, John

    2016-04-01

    The results of visual double star observing sessions suggested a pattern for STT doubles with large DM of being harder to resolve than would be expected based on the WDS catalog data. It was felt this might be a problem with expectations on one hand, and on the other might be an indication of a need for new precise measurements, so we decided to take a closer look at a selected sample of STT doubles and do some research. We found that like in the other constellations covered so far (Gem, Leo, UMa, etc.) at least several of the selected objects in Ophiuchus and Hercules show parameters quite different from the current WDS data.

  20. Impact of faecal DM excretion on faecal calcium losses in dogs eating complete moist and dry pet foods - food digestibility is a major determinant of calcium requirements.

    Science.gov (United States)

    Kienzle, Ellen; Brenten, Thomas; Dobenecker, Britta

    2017-01-01

    The recommendations for the Ca supply for maintenance of dogs have been reduced by about 75 % in the last decades. An important factor for Ca requirements is faecal Ca losses. In previous studies with experimental diets faecal Ca losses depended on Ca intake and on faecal DM excretion. A predictive equation for faecal Ca losses in mg/kg body weight (BW) developed in a fibre model is: faecal losses = -33·8 + (13·6 faecal DM excretion (g/kg BW)) + (0·78 Ca intake (mg/kg BW)). The present study aimed at testing this equation in pet food with material from trials carried out for other purposes. Digestion trials with twenty-five dry and fifteen moist foods (326 observations in total) were evaluated retrospectively. Faecal DM excretion and faecal Ca losses were significantly correlated (r(2) 0·86; P food. Faecal DM excretion has a considerable impact on faecal Ca losses in a practical feeding situation. In conclusion, Ca requirements for maintenance may vary with food DM intake and digestibility.

  1. Educational intervention regarding diet and physical activity for pregnant women: changes in knowledge and practices among health professionals.

    Science.gov (United States)

    Malta, Maíra Barreto; Carvalhaes, Maria Antonieta de Barros Leite; Takito, Monica Yuri; Tonete, Vera Lucia Pamplona; Barros, Aluísio J D; Parada, Cristina Maria Garcia de Lima; Benício, Maria Helena D'Aquino

    2016-07-20

    The knowledge and practices of health professionals have a recognized role in behaviors related to the health of their patients. During pregnancy, this influence can be even stronger because there is frequent contact between women and doctors/nurses at periodic antenatal visits. When trained, supported and motivated, these professionals can act as health promoters. This study aimed to evaluate the effect of a focused educational intervention on improving the knowledge and practices of health professionals concerning diet and physical activity during pregnancy. A controlled, non-randomized study was performed to assess the effects of an educational intervention on the knowledge and practices of nurses and doctors who provide primary care to pregnant women. The intervention group, doctors and nurses (n = 22) from the family health units in a medium-sized city of São Paulo State, Brazil, received 16 h of training comprising an introductory course and three workshops, whereas the control group, doctors and nurses (n = 20) from traditional basic health units in Botucatu, did not. The professionals' knowledge was assessed at two time points, 1 month prior to and 1 year after the beginning of the intervention, using an ad hoc self-report questionnaire. The increases in the knowledge scores for walking and healthy eating of the intervention and control groups were calculated and compared using Student's t-test. To analyze the professionals' practice, women in the second trimester of pregnancy were asked whether they received guidance on healthy eating and leisure-time walking; 140 of these women were cared for by professionals in the intervention group, and 141 were cared for by professionals in the control group. The percentage of pregnant women in each group that received guidance was compared using the chi-square test and the Prevalence Ratio (PR), and the corresponding 95 % confidence intervals (CI) were calculated. The intervention improved the

  2. Daily methane production pattern of Welsh ponies fed a roughage diet with or without a cereal mixture

    NARCIS (Netherlands)

    Dansen, O.; Pellikaan, W.F.; Hendriks, W.H.; Dijkstra, J.; Jacobs, M.P.T.; Everts, H.; Doorn, van D.A.

    2015-01-01

    Methane production from Welsh ponies fed 2 isoenergetic diets (NE basis) at maintenance was studied in a crossover design with 4 mature geldings (230 ± 10.5 kg BW, mean ± SE). Treatments included a roughage-only (R) diet (5.1 kg DM/d) or a roughage plus cereal mix (RC) diet (2.5 kg DM hay/d plus 1.1

  3. High dietary zinc supply reduces the digestibility of phosphorus in pig diets1

    DEFF Research Database (Denmark)

    Poulsen, Hanne Damgaard; Blaabjerg, Karoline; Sørensen, Kristina Ulrich

    2016-01-01

    . However, divalent metal ions may bind phytate, leaving phytate less accessible to phytase-induced hydrolysis. The objective was to examine the effects of increased Zn supply on the apparent total tract digestibility (ATTD) of P in pig diets supplemented with microbial phytase. A wheat, barley, and soy......–based diet (4.3 g P/kg DM, 3.1 g phytate P/kg DM, and no feed phosphate) were heat treated at 81°C (plant phytase

  4. DM100 AND DM1200 MELTER TESTING WITH HIGH WASTE LOADING GLASS FORMULATIONS FOR HANFORD HIGH-ALUMINUM HLW STREAMS

    Energy Technology Data Exchange (ETDEWEB)

    KRUGER AA; MATLACK KS; KOT WK; PEGG IL; JOSEPH I

    2009-12-30

    This Test Plan describes work to support the development and testing of high waste loading glass formulations that achieve high glass melting rates for Hanford high aluminum high level waste (HLW). In particular, the present testing is designed to evaluate the effect of using low activity waste (LAW) waste streams as a source of sodium in place ofchemical additives, sugar or cellulose as a reductant, boehmite as an aluminum source, and further enhancements to waste processing rate while meeting all processing and product quality requirements. The work will include preparation and characterization of crucible melts in support of subsequent DuraMelter 100 (DM 100) tests designed to examine the effects of enhanced glass formulations, glass processing temperature, incorporation of the LAW waste stream as a sodium source, type of organic reductant, and feed solids content on waste processing rate and product quality. Also included is a confirmatory test on the HLW Pilot Melter (DM1200) with a composition selected from those tested on the DM100. This work builds on previous work performed at the Vitreous State Laboratory (VSL) for Department of Energy's (DOE's) Office of River Protection (ORP) to increase waste loading and processing rates for high-iron HLW waste streams as well as previous tests conducted for ORP on the same waste composition. This Test Plan is prepared in response to an ORP-supplied statement of work. It is currently estimated that the number of HLW canisters to be produced in the Hanford Tank Waste Treatment and Immobilization Plant (WTP) is about 12,500. This estimate is based upon the inventory ofthe tank wastes, the anticipated performance of the sludge treatment processes, and current understanding of the capability of the borosilicate glass waste form. The WTP HLW melter design, unlike earlier DOE melter designs, incorporates an active glass bubbler system. The bubblers create active glass pool convection and thereby improve heat

  5. Ketogenic diet

    Directory of Open Access Journals (Sweden)

    Tina Bregant

    2009-04-01

    conclusions This review traces a history of ketogenic diet, reviews its uses and side effects, and discusses possible alternatives and the diet’s possible mechanisms of action. We show how to use the diet in practice. Protocol and calculations are presented. We look toward possible future uses of the ketogenic diet, since it is efficient, under doctor’s supervison safe, but very demanding, additional treatment.

  6. CRAMBE CAKE (Crambe abyssinica hochst ON LAMB DIETS

    Directory of Open Access Journals (Sweden)

    Érika Breda Canova

    2015-02-01

    Full Text Available The use of alternative feedstuffs in animal diet, such as residues derived from the biodiesel production aims to increase productivity and reduce costs in animal production. Them aim of this study was to evaluate the substitution effect of 0, 22, 44 and 64% of soybean meal protein by Crambe cake (Crambe abyssinica Hochst protein in lamb diet. In the in vivo experiment, 20 lambs were used and evaluated the apparent digestibility, nitrogen balance and voluntary DM intake. The replacement of the protein resulted in a linear decrease in apparent digestibility coefficient (ADC of dry matter (DM, organic matter (OM, ether extract (EE, gross energy (GE, acid detergent fiber (ADF, neutral detergent fiber (NDF, cellulose (CEL and the percentage of total digestible nutrients (TDN, which resulted in decreased daily DM intake. The blood level of urea, glucose, alanine aminotransferase (ALT and aspartate aminotransferase (AST were not affected. In vitro gas production technique (GP evaluation of diets showed a significantly decrease (P<0.05 of the total gas and methane production without altering the true degradability of DM and OM and the partition factor (PF. Replacement of soybean meal protein by the Crambe cake protein decreased digestibility of the fiber fraction of the diet, the voluntary intake of DM and methane, without altering rumen fermentation. Crambe cake can be utilized as lamb's food, because, despite reduced intake, assure a large energy intake and similarity to soybean meal protein.

  7. Comparison of Three Instructional Strategies in Food and Nutrition Education: Developing a Diet Plan for a Diabetic Case

    Science.gov (United States)

    Darabi, Aubteen; Pourafshar, Shirin; Suryavanshi, Rinki; Arrington, Thomas

    2016-01-01

    This study examines the performance of dietitians-in-training on developing a diet plan for a diabetic patient either independently or after peer discussion. Participants (n = 58) from an undergraduate program in food and nutrition were divided into two groups based on their prior knowledge before being randomly assigned into three conditions: (1)…

  8. Efficacy of a nutritional education program to improve diet in patients attending a cardiac rehabilitation program: outcomes of a one-year follow-up.

    Science.gov (United States)

    Luisi, Maria Luisa Eliana; Biffi, Barbara; Gheri, Chiara Francesca; Sarli, Ennio; Rafanelli, Elena; Graziano, Emanuela; Vidali, Sofia; Fattirolli, Francesco; Gensini, Gian Franco; Macchi, Claudio

    2015-09-01

    Dietary habits are widely reported to play a primary role in the occurrence of coronary artery disease (CAD). Cardiac rehabilitation is a multidisciplinary intervention that includes nutritional education. Proper nutrition plays an important role in cardiovascular health outcomes and in decreasing morbidity and mortality of cardiovascular diseases (CVD) as highlighted in the literature. The aim of this study was to assess the efficacy of an educational program to improve the diet of cardiac rehabilitation patients compared to usual treatment. 160 patients with CAD, (124 M, 36 F) were randomized into two groups. Data analysis was conducted on 133 patients (11 % dropped out). All enrolled patients attended two educational seminars about proper nutrition and cardiovascular prevention, and completed a questionnaire about dietary habits (before CAD). The Body Mass Index (BMI) was calculated, and basal glycaemia and plasma lipids were assessed at the beginning and at the end of the study (12 months after hospital discharge). The intervention group patients underwent a mid-term evaluation of nutrient intakes, BMI, and received a personalized educational reinforcement by a dietitian. At the end of the study, the intervention group was shown to have significantly reduced their daily caloric intake (reduction of total proteins, total fat, carbohydrate, alcohol), and showed a significant reduction of weight and BMI compared to the control group. Individual nutritional counseling session as a reinforcement of a standard educational program is effective in reducing caloric intake and BMI, which may reduce cardiovascular risk factors in cardiovascular patients.

  9. Adiponectin may improve osseointegration of dental implants in T2DM patients.

    Science.gov (United States)

    Bai, Yun; Yin, Guozhu; Luo, En

    2011-08-01

    Type 2 diabetes mellitus (T2DM) is the most common form of diabetes. Compared with the general population, a higher failure rate is seen in T2DM patients. There is also evidence that chronically high levels of plasma glycemia leads to inflammatory effect and a negative influence on bone formation and remodeling, and reduce osseointegration of implants. Recently studies reveal that adiponectin is an insulin-sensitizing adipokine, and closely associated with T2DM. Adiponectin has potent anti-inflammatory properties and has been shown to increase bone density by inhibiting osteoclast formation and promoting the formation of osteoblasts. We therefore hypothesize systemically infused or locally used adiponectin could accelerate osseointegration of dental implants in T2DM. Our hypothesis could help to create an option to improve success ratio of dental implants in T2DM by the replenishment of adiponectin in T2DM patients.

  10. The possible importance of income and education as covariates in cohort studies that investigate the relationship between diet and disease [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Norman Temple

    2016-05-01

    Full Text Available Background:  Many cohort studies have been carried out that have provided information on the relationship between diet and health-related outcomes. Omission of important covariates during multivariate analysis may give rise to error due to residual confounding. A possibly important covariate is socioeconomic status (SES as this is related to both diet and health. Objective: To determine the frequency with which different measures of SES are included as covariates during multivariate analysis of cohort studies that investigated the relationship between diet and health. Methodology:  An analysis was carried out of 76 randomly selected papers from 66 cohort studies. The papers covered many dietary variables and a wide variety of diseases/health-related outcomes. The cohort studies were carried out in many different locations and the subjects varied widely in age. Results:  Approximately two-thirds of the papers (65.8% used at least one measure of SES as a covariate. Education was used most often (60.5% of papers, followed by income (14.4% and social class (2.6%. More than one measure of SES was used in 11.8% of papers. Conclusions:  Failure to include income (or another measure of present SES, such as occupation may be a common source of error in cohort studies. Over-reliance on education may be particularly important as it is likely to be a weaker measure of present SES than is income. There is a need for more research on this question. SES in childhood is almost never included in multivariate analysis in cohort studies carried out on adults. This could also play a significant role in disease risk in middle age or later. Very little is known regarding whether this is also a source of residual confounding.

  11. Vegan diets and hypothyroidism.

    Science.gov (United States)

    Tonstad, Serena; Nathan, Edward; Oda, Keiji; Fraser, Gary

    2013-11-20

    Diets eliminating animal products have rarely been associated with hypothyroidism but may protect against autoimmune disease. Thus, we investigated whether risk of hypothyroidism was associated with vegetarian compared to omnivorous dietary patterns. The Adventist Health Study-2 was conducted among church members in North America who provided data in a self-administered questionnaire. Hypothyroidism was queried at baseline in 2002 and at follow-up to 2008. Diet was examined as a determinant of prevalent (n = 4237 of 65,981 [6.4%]) and incident cases (1184 of 41,212 [2.9%]) in multivariate logistic regression models, controlled for demographics and salt use. In the prevalence study, in addition to demographic characterstics, overweight and obesity increased the odds (OR 1.32, 95% CI: 1.22-1.42 and 1.78, 95% CI: 1.64-1.93, respectively). Vegan versus omnivorous diets tended to be associated with reduced risk (OR 0.89, 95% CI: 0.78-1.01, not statistically significant) while a lacto-ovo diet was associated with increased risk (OR 1.09, 95% CI: 1.01-1.18). In the incidence study, female gender, white ethnicity, higher education and BMI were predictors of hypothyroidism. Following a vegan diet tended to be protective (OR 0.78, 95% CI: 0.59-1.03, not statistically significant). In conclusion, a vegan diet tended to be associated with lower, not higher, risk of hypothyroid disease.

  12. Evaluation of collection method and diet effects on apparent digestibility and energy values of swine diets.

    Science.gov (United States)

    Li, Y S; Tran, H; Bundy, J W; Burkey, T E; Kerr, B J; Nielsen, M K; Miller, P S

    2016-06-01

    Two experiments were conducted to investigate the effects of collection method and diet type on digestibility coefficients. In Exp. 1, 24 barrows were fed either a corn-soybean meal (CSBM) diet or CSBM with 20% dried distillers' grains with solubles (CSBM-DDGS). In Exp. 2, the effects of basal diet and collection method on determination of dried distillers' grains with solubles (DDGS) digestibility were studied using 24 barrows. The 4 diets used in Exp. 2 were: a CSBM (basal 1) , a barley-canola meal (BCM; basal 2), 80% basal 1 with 20% DDGS (CSBM-DDGS), and 80% basal 2 with 20% DDGS (BCM-DDGS). In both experiments, feces were collected using a time-based collection method (DY) or a "marker-to-marker" collection method (MM). Diets contained 0.5% of titanium dioxide (TiO) for estimating digestibility using the index marker approach (IM). The apparent total tract digestibility (ATTD) of DM and GE were lower ( diet than in the CSBM diet in Exp. 1 but were not different in Exp. 2. All the estimates of BCM-based diets were consistently lower ( diets. In Exp. 1, digestibility coefficients determined by the DY and MM were not different from each other, whereas those estimates were lower ( diet type and method for dietary digestibility coefficients. Digestibility and energy values estimated by the DY and MM were not different in pigs fed CSBM-based diets and the BCM-DDGS diet, whereas those estimates were greater ( diet and method for estimating DDGS digestibility. The ATTD of DM and GE of DDGS using the MM were greater ( diets. The mean DE and ME (as-fed basis) of DDGS were 3,994 and 3,688 kcal/kg, respectively, when estimated using the basal 1 diet and were 3,919 and 3,547 kcal/kg, respectively, when estimated using the basal 2 diet. In conclusion, both collection methods can be used to estimate energy and nutrient digestibility of diets and DDGS when using CSBM-based diets.

  13. IceCube Events from Heavy DM decays through the Right-handed Neutrino Portal

    CERN Document Server

    Ko, P

    2015-01-01

    The recently observed IceCube PeV events could be due to heavy dark matter (DM) decay. In this paper, we propose a simple DM model with extra $U(1)_X$ gauge symmetry and bridge it with standard model particles through heavy right-handed neutrino. The Dirac fermion DM $\\chi$ with mass ~5 PeV can dominantly decay into a dark Higgs ($\\phi$), the SM Higgs ($h$) and a neutrino ($\

  14. Associations between diet quality, health status and diabetic complications in patients with type 2 diabetes and comorbid obesity.

    Science.gov (United States)

    Mangou, Apostolis; Grammatikopoulou, Maria G; Mirkopoulou, Daphne; Sailer, Nikolaos; Kotzamanidis, Charalambos; Tsigga, Maria

    2012-02-01

    Patients with type 2 diabetes (T2DM) demonstrate low dietary adherence and this is further aggravated with comorbid obesity. The aim of the present study was to assess diet quality in patients with T2DM and comorbid obesity compared to patients with T2DM alone and to examine the associations between comorbidities and diet quality. The sample consisted of 59 adult patients with diabesity (T2DM and comorbid obesity) and 94 patients with T2DM alone. All diabetes comorbidities and complications were recorded and diet quality was assessed with the Healthy Eating Index (HEI). Mean raw HEI of the diabese subjects was 81.9±7.1 and the diabetic subjects was 80.2±6.9. When HEI was adjusted to the sex, age and weight status, the diabese demonstrated a higher HEI. Among comorbidities, only renal disease decreased HEI. According to the principal component analysis of the total sample, adequate diet quality was explained by cardiovascular disease, cigarette smoking, alcohol consumption, peptic ulcer, sex, diabesity and diabetic foot syndrome. In the diabese, adequate HEI was explained by diabetic foot syndrome, smoking, drinking alcohol and having a family history of diabetes. Adult patients with T2DM demonstrate adequate diet quality. Different factors are associated with the adoption of a high quality diet between the diabese and the T2DM alone. Copyright © 2011 SEEN. Published by Elsevier Espana. All rights reserved.

  15. Fat- and fiber-related diet behavior among type 2 diabetes patients from distinct regions

    Directory of Open Access Journals (Sweden)

    Hendrychova T

    2015-02-01

    Full Text Available Tereza Hendrychova,1 Magda Vytrisalova,1 Abdullah Alwarafi,2 Jurjen Duintjer Tebbens,3,4 Helena Vankatova,1 Sandra Leal,5 Ales Antonin Kubena,1 Alena Smahelova,6 Jiri Vlcek1 1Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic; 2Faculty of Dentistry, Ibb University, Ibb, Yemen; 3Department of Biophysics and Physical Chemics, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic; 4Institute of Computer Science, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 5Department of Clinical Pharmacy, El Rio Community Health Center, Tucson, AZ, USA; 6Diabetes Center, Department of Gerontology and Metabolism, University Hospital and Faculty of Medicine in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic Purpose: Diet and eating habits are of key importance in patients with type 2 diabetes mellitus (T2DM. The purpose of this comparative study was to analyze fat- and fiber-related behavior (FFB in patients with T2DM from distinct cultural areas. Patients and methods: Observational study was carried out in the Czech Republic (CR (n=200, the US (n=207, and Yemen (n=200. Patients completed the Fat- and Fiber-related Diet Behavior Questionnaire (FFBQ. Results: Differences in all aspects of FFB among countries were found (P<0.05. The best fat-related behavior reported was from patients from the CR. Patients from the US showed the worst fat-related behavior in total. On the other hand, patients from the US reported the best fiber-related behavior. Patients from Yemen reached the worst scores in all fat-related domains. Patients from all studied countries reported the best results in the “modify meat” and “avoid fat as flavoring” and the worst in the “substitute high fiber” subscales. Conclusion: Professionals involved in the diet education of T2DM patients

  16. Performance Study of CM/DM Discrimination Network for Conducted EMI Diagnosis

    Institute of Scientific and Technical Information of China (English)

    ZHAOYang; SEEKyeYak

    2003-01-01

    This paper compares the discrimination capability for four different types of Common-mode and Differential-mode Discrimination networks (CM/DM DN). The insertion losses and mode rejection performances for the four CM/DM DNs are measured. Based on the measured results, the CM/DM DN with the best discrimination capability is chosen for the purpose of conducted EMI diagnosis. A practical example is shown to demonstrate the ease of EMI diagnosis, with the aid of the chosen CM/DM DN.

  17. Organizacijska kultura v podjetju dm drogerie markt d.o.o.

    OpenAIRE

    Renko, Jure

    2016-01-01

    Organizacijska kultura pomembno vpliva na uspešnost posameznika v organizaciji in uspeh podjetja pri strankah. V diplomskem delu smo preučili organizacijsko kulturo v podjetju dm drogerie markt d.o.o., ki je del koncerna dm. Management v koncernu dm se zaveda pomembnosti tega kompleksnega in dinamičnega pojava. V dm Slovenija smo naredili raziskavo s pomočjo anketnega vprašalnika, kjer smo izmerili trenutno in želeno organizacijsko kulturo z vidika zaposlenih in s stališča lastnikov. Na podla...

  18. Toward electroweak scale cold dark matter with local dark gauge symmetry and beyond the DM EFT

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Pyungwon, E-mail: pko@kias.re.kr [School of Physics, Korea Institute for Advanced Study 85 Hoegiro, Dongdaemun-gu, Seoul 02455 (Korea, Republic of)

    2016-06-21

    In this talk, I describe a class of electroweak (EW) scale dark matter (DM) models where its stability or longevity are the results of underlying dark gauge symmetries: stable due to unbroken local dark gauge symmetry or topology, or long-lived due to the accidental global symmetry of dark gauge theories. Compared with the usual phenomenological dark matter models (including DM EFT or simplified DM models), DM models with local dark gauge symmetries include dark gauge bosons, dark Higgs bosons and sometimes excited dark matter. And dynamics among these fields are completely fixed by local gauge principle. The idea of singlet portals including the Higgs portal can thermalize these hidden sector dark matter very efficiently, so that these DM could be easily thermal DM. I also discuss the limitation of the usual DM effective field theory or simplified DM models without the full SM gauge symmetry, and emphasize the importance of the full SM gauge symmetry and renormalizability especially for collider searches for DM.

  19. Gut microbiota and Ma-Pi 2 macrobiotic diet in the treatment of type 2 diabetes.

    Science.gov (United States)

    Fallucca, Francesco; Fontana, Lucia; Fallucca, Sara; Pianesi, Mario

    2015-04-15

    In the past 10 years the prevalence of type 2 diabetes mellitus (T2DM) has increased hugely worldwide, driven by a rise in the numbers of overweight and obese individuals. A number of diets have been shown to be effective for the management of T2DM: the Mediterranean diet, the vegetarian diet and the low-calorie diet. Results of studies clearly indicate, however, that the efficacy of these diets is not solely related to the biochemical structure of the individual nutrients they contain. This review discusses this point with reference to the potential role of the intestinal microbiota in diabetes. The macrobiotic Ma-Pi 2 diet is rich in carbohydrates, whole grains and vegetables, with no animal fat or protein or added sugar. In short- and medium-term trials conducted in patients with T2DM, the Ma-Pi 2 diet has been found to significantly improve indicators of metabolic control, including fasting blood glucose, glycosylated hemoglobin, the serum lipid profile, body mass index, body weight and blood pressure. The diet may also alter the gut microbiota composition, which could additionally affect glycemic control. As a result, the Ma-Pi 2 diet could be considered a valid additional short- to medium-term treatment for T2DM.

  20. "It was an education in portion size". Experience of eating a healthy diet and barriers to long term dietary change.

    Science.gov (United States)

    Macdiarmid, J I; Loe, J; Kyle, J; McNeill, G

    2013-12-01

    The aim of the study was to explore the expectations and experience of actually eating a healthy diet and using this experience to identify barriers to healthy eating and sustainable dietary change. Fifty participants (19-63 yrs) were provided with a healthy diet (i.e. complied with dietary recommendations) for three consecutive days. Afterwards a semi-structured interview was carried out to explore expectations, experience and barriers to healthy eating. Using a thematic analysis approach eight dominant themes emerged from the interviews. Four related to expectations and experience of healthy eating; realisation of what are appropriate portion sizes, an expectation to feel hungry, surprise that healthy diets comprised normal food, the desire for sweet snacks (e.g. chocolate). This demonstrated there are some misconception about healthy eating and distorted views of portion size. Four more themes emerged relating to barriers to healthy eating; competing priorities, social, peer and time pressure, importance of value for money, a lack of desire to cook. Poor knowledge of healthy eating or a lack of cooking skills were the least common barrier, suggesting that future interventions and policy to improve dietary intakes need to focus on social, cultural and economic issues rather than on lack of knowledge or skills. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Attitudes and barriers to exercise in adults with type 1 diabetes (T1DM and how best to address them: a qualitative study.

    Directory of Open Access Journals (Sweden)

    Nadia Lascar

    Full Text Available Regular physical activity has recognised health benefits for people with T1DM. However a significant proportion of them do not undertake the recommended levels of activity. Whilst questionnaire-based studies have examined barriers to exercise in people with T1DM, a formal qualitative analysis of these barriers has not been undertaken. Our aims were to explore attitudes, barriers and facilitators to exercise in patients with T1DM.A purposeful sample of long standing T1DM patients were invited to participate in this qualitative study. Twenty-six adults were interviewed using a semi-structured interview schedule to determine their level of exercise and barriers to initiation and maintenance of an exercise programme.Six main barriers to exercise were identified: lack of time and work related factors; access to facilities; lack of motivation; embarrassment and body image; weather; and diabetes specific barriers (low levels of knowledge about managing diabetes and its complications around exercise. Four motivators to exercise were identified: physical benefits from exercise; improvements in body image; enjoyment and the social interaction of exercising at gym or in groups. Three facilitators to exercise were identified: free or reduced admission to gyms and pools, help with time management, and advice and encouragement around managing diabetes for exercise.Many of the barriers to exercise in people with T1DM are shared with the non-diabetic population. The primary difference is the requirement for education about the effect of exercise on diabetes control and its complications. There was a preference for support to be given on a one to one basis rather than in a group environment. This suggests that with the addition of the above educational requirements, one to one techniques that have been successful in increasing activity in patients with other chronic disease and the general public should be successful in increasing activity in patients with T1DM.

  2. Mediterranean Diet and Cardiodiabesity: A Review

    Science.gov (United States)

    García-Fernández, Elena; Rico-Cabanas, Laura; Rosgaard, Nanna; Estruch, Ramón; Bach-Faig, Anna

    2014-01-01

    Cardiodiabesity has been used to define and describe the well-known relationship between type 2 Diabetes Mellitus (T2DM), obesity, the metabolic syndrome (MetS) and cardiovascular disease (CVD). The objective of this study was to perform a scientific literature review with a systematic search to examine all the cardiovascular risk factors combined and their relationship with adherence to the Mediterranean Diet (MedDiet) pattern as primary prevention against cardiodiabesity in a holistic approach. Research was conducted using the PubMed database including clinical trials, cross-sectional and prospective cohort studies. Thirty-seven studies were reviewed: fourteen related to obesity, ten to CVD, nine to MetS, and four to T2DM. Indeed 33 provided strong evidence on the association between adherence to a MedDiet and a reduced incidence of collective cardiodiabesity risk in epidemiological studies. This scientific evidence makes the MedDiet pattern very useful for preventive strategies directed at the general population and also highlights the need to consider all these diet-related risk factors and health outcomes together in daily primary care. PMID:25192027

  3. Diet & Nutrition

    Science.gov (United States)

    ... Giving d Employer Matching Gifts d Gifts of Stock or Securities d Giving Circles Golden Circle Circle ... health. Shelly Diagnosed in 2006 Diet & Nutrition Take Control of Your Weight Portion Control Low Carb Omega- ...

  4. Comparison of Effect of Two Methods of Face-to-Face Education and Distance Education (via Short Message Service on Amount of Following Remedial Diet in Patients Suffering From Hypertension

    Directory of Open Access Journals (Sweden)

    Basiri

    2016-04-01

    Full Text Available Background A large amount of money is allocated to hypertension in terms of remedial and care costs, but fighting against this disease begins with education. Objectives This study has been conducted with the aim of comparing the effect of two methods: face-to-face education and distance education (via short message service [SMS] on amount of following remedial diet in patients suffering from hypertension. Patients and Methods In this clinical trial study, 72 patients who were suffering from hypertension participated. They were selected by the purposeful sampling from three hospitals in Abadan city, Iran. Each of the three groups were similar in terms of age, gender, level of education, marital status, and duration of suffering from hypertension. The first group was under face-to-face education for eight sessions of 30 minutes; the second group under distance education (via SMS; and the third group did not receive any education as they were the control group. The tools used for collecting data involved three questionnaires (demographic data [two parts], following medicinal diet (three parts: MMAS-3, therapeutic lifestyle changes, and dietary approach to stop hypertension, and evaluating the amount of patients’ awareness about their disease. This study applied descriptive and deductive statistics with SPSS Version 20 for statistical analysis. Results The results showed that the mean of examined realms, after interference in both the face-to-face and the distance education groups, had a significant statistical difference with the before-interference mean (P = 0.0001. Inter-group comparison between systolic and diastolic blood pressure and awareness realms showed that there was a significant statistical difference between the face-to-face education group compared with the control group (P < 0.05. However, in other realms, no significant statistical difference was observed between the two educational groups (P < 0.05. Conclusions Having access to

  5. Myotonic dystrophy (DM1) and dysphagia: the need for dysphagia management guidelines and an assessment tool

    NARCIS (Netherlands)

    LaDonna, K.A.; Koopman, W.J.H.; Venance, S.L.

    2011-01-01

    Myotonic dystrophy (DM1) is the most prevalent muscular dystrophy occurring in adulthood. DM1 is a multi-systemic disorder resulting in early-onset cataracts, cardiac rhythm problems, muscle weakness, ptosis, and cognitive and psychiatric manifestations. Dysphagia is one of the most problematic

  6. Comparative experimental and theoretical investigations of the DM neutron moisture probe

    DEFF Research Database (Denmark)

    Ølgaard, Povl Lebeck; Haahr, Vagner

    1967-01-01

    Theoretical and experimental investigations of the Danish produced DM subsurface moisture probe have been carried out at the Research Establishment Risö, and the results obtained are presented in this paper. The DM probe contains an Am-Be fast neutron source and has a glass scintillator containi...

  7. Registration of an oilseed sunflower germplasm HA-DM1 resistant to sunflower downy mildew

    Science.gov (United States)

    HA-DM1 (Reg. No.xxx, PI 674793) sunflower (Helianthus annuus L.) germplasm was developed and released cooperatively by the USDA-ARS, Sunflower and Plant Biology Research Unit and the North Dakota Agricultural Experiment Station in 2015. HA-DM1 is a BC2F4 derived oilseed maintainer line from the cros...

  8. A Public Educational Guideline Development to Relieve Post Menopausal Hot Flashes Symptoms in Women between 45-60 Years Old Based on Proper Diet and Exercise

    Directory of Open Access Journals (Sweden)

    Rozita Firooznia

    2014-04-01

    Full Text Available Introduction: The study purpose was to develop a public education guideline for reducing menopausal symptoms and its complications based on proper diet and exercise in women between 45-60 years old. Methods: It was a combined study designed in two stages. The first stage was a systematic review. All of the articles which focused on the effects of diet and physical activity on reducing hot flash after menopause that published in Iran and abroad since 10 years ago were extracted and the results recorded. In the next stage, a panel of experts was held. Through a qualitative method, the specialists discussed the obtained results from the reviewed articles. The outcome presented in a booklet format. Results: 410 articles were obtained from external and internal sources, and by eliminating redundant and irrelevant articles, the results of 77 articles were analyzed; 40 of these articles were about diet and 37 articles were about physical activity. The summarized results showed that daily using of phytoestrogen supplements such as passion flower extract 60 drops, vitagnous extracts 40 drops, licorice extract powder 60 mg or ingestion of 60 g of baked soybean powder, along with moderate to high- intensity aerobic activities such as 30-45 minutes walking (3-5 days a week were effective in reducing the hot flash’s symptom of women between 45-60 years old. Conclusion: Finding showed that regular physical activities and dietary regimen containing phytoestrogens such as passion flower, vitagnous and licorice extract, and soybeans are effective to relieve hot flash symptoms in menopause women.

  9. The effect of a diet education with six iso-caloric meals on the body weight and blood glucose of diabetes type 2 patients

    Directory of Open Access Journals (Sweden)

    Musa Salehi

    2012-06-01

    Full Text Available The treatment of Diabetes should not only be sought through drug administration; diet is also a part of its treatment. The aim of this study was to determine the effect of a diet with six meals having equal calories on the body weight and blood glucose on diabetes type 2 patients. This research is an Experimental study conducted in 2009 on 181 patients with diabetes. The patients visited the IDSF (Iranian Diabetes Society of Fars weekly and the patients to be studied were randomly divided into two groups of 85 and 96 patients, respectively. The participants were repeatedly requested to consume their calculated calorie in six equal parts. The average age in the Experimental and Control groups were 51.2 ± 13.3 and 53.1 ± 9.4, respectively. The mean body weight and fasting blood glucose at the beginning of the study in Experimental and Control groups were 66.3 ± 9.4 and 69.1 ± 11.1 kg, 198.9 ± 35.1, and 199.8 ± 39.1 mg.dL-1, respectively. At the end of the study, however, the values were 63.5 ± 7.5 and 66.98 ± 9 kg, 139.5 ± 34.6 and 164.2 ± 22.1 mg.dL-1, respectively. Only the mean fasting blood glucose at the end of the study revealed a significant difference (p-value = 0.001. The results show that educating those afflicted with Diabetes Type 2 aiming at changing their diet can greatly help them manage their blood glucose.

  10. Interference effects of two scalar boson propagators on the LHC search for the singlet fermion DM

    CERN Document Server

    Ko, P

    2016-01-01

    A gauge invariant UV-completion for singlet fermion DM interacting with the standard model (SM) particles involves a new singlet scalar. Therefore the model contains two scalar mediators, mixtures of the SM Higgs boson and a singlet scalar boson. Collider phenomenology of the interference effect between these two scalar propagators is studied in this work. This interference effect can be either constructive or destructive in the DM production cross section depending on both singlet scalar and DM masses, and it will soften the final state jets in the full mass region. Applying the CMS mono-jet search to our model, we find the interference effect plays a very important role in the DM search sensitivity, and the DM production cross section of our model is more than one order of magnitude below the LHC sensitivity at current stage.

  11. Interference effects of two scalar boson propagators on the LHC search for the singlet fermion DM

    Science.gov (United States)

    Ko, P.; Li, Jinmian

    2017-02-01

    A gauge invariant UV-completion for singlet fermion DM interacting with the standard model (SM) particles involves a new singlet scalar. Therefore the model contains two scalar mediators, mixtures of the SM Higgs boson and a singlet scalar boson. Collider phenomenology of the interference effect between these two scalar propagators is studied in this work. This interference effect can be either constructive or destructive in the DM production cross section depending on both singlet scalar and DM masses, and it will soften the final state jets in the full mass region. Applying the CMS mono-jet search to our model, we find the interference effect plays a very important role in the DM search sensitivity, and the DM production cross section of our model is more than one order of magnitude below the LHC sensitivity at current stage.

  12. The Effect of Nutrition Education on Nutrition and Diet of Patients With Type 2 Diabetes Mellitus%营养教育对2型糖尿病患者营养与饮食知-信-行的干预作用

    Institute of Scientific and Technical Information of China (English)

    王嘉佳; 牛兆青; 孙波

    2015-01-01

    Objective To investigate the effect of nutrition education on nutrition and diet knowledge of patients with type 2 diabetes melitus.Methods 100 patients with T2DM were treated with nutrition education,and the effect of comprehensive intervention was evaluated. Results Compared with preeducation,the overal awareness rate and nutritional knowledge score of patients with diabetes were significantly higher than that in patients with diabetes melitus(P< 0.01). The patients with positive dietary and lifestyle attitudes were significantly higher(P< 0.05).Conclusion Nutrition education is an effective method to improve the nutrition and diet knowledge of diabetes patients,and it has high clinical application value.%目的:探讨营养教育对2型糖尿病患者营养与饮食知识、态度和行为的干预效果。方法对我院收治的100例T2DM患者进行营养教育,对综合干预效果进行评价。结果与宣教前相比,宣教后患者对糖尿病饮食知识的总体知晓率及营养知识评分均升高(P<0.01),宣教后患者对积极饮食和生活方式态度的认同率升高(P<0.05),患者对血糖指数及负荷知识的需求更为急切,知识获取途径开始转向营养门诊及医护人员(P<0.01)。结论营养教育是改善糖尿病患者营养与饮食知-信-行的有效方法。

  13. 酸性皂洗剂DM-1530应用实践%The application practice of the acid soaping agent DM-1530

    Institute of Scientific and Technical Information of China (English)

    季金霞; 胡灿辉; 吴少新

    2009-01-01

    酸性皂洗剂DM-1530将酸中和与皂洗合二为一,可以替代醋酸起到中和作用,而且皂洗效果极佳.以大红色纯棉双面针织布为例,分析了不同pH值、DM-1530用量、水的硬度对DM-1530皂洗效果的影响,并通过生产实践,介绍了传统工艺和DM-1530工艺的流程,比较分析了二者的pH值变化情况、皂洗牢度以及生产成本.表明,使用DM-1530可省去皂洗前的酸中和工艺,节约能源,减少污水排放,缩短工艺流程,提高工作效率,皂洗效果良好.

  14. Influence of replacing corn silage with barley silage in the diets of buffalo cows on milk yield and quality.

    Science.gov (United States)

    Tudisco, R; Calabrò, S; Grossi, M; Piccolo, G; Guglielmelli, A; Cutrignelli, M I; Caiazzo, C; Infascelli, F

    2010-06-01

    A 150-day trial was carried out on 40 Italian Mediterranean buffalo cows that, immediately after calving, were equally divided into two homogeneous groups (M and O) based on the number of calving events and previous milk yield. The animals were fed (16 kg dry matter (DM)/head) two isoenergy/isoprotein diets (NEl: 6.39 MJ/kg DM; 15.4 CP% DM), composed of corn (diet M) or barley silage (diet O) concentrate, alfalfa hay, and a vitamin-mineral supplement. The fermentation characteristics of both silage diets were evaluated by an in vitro gas production technique, and their nutritional values were calculated as follows: NEl (MJ/kg DM) = 0.54 + 0.0959 GP + 0.0038 CP + 0.0001733 CP(2), where GP is the gas production after 24 h of incubation (ml/200 mg DM) and CP is the protein content of silage (g/kg DM). The nutritional values of the silages were slightly different (4.16 vs. 4.14 MJ/kg DM for M and O, respectively) likely due to the high content of hemicellulose in the O diet (22.0 vs. 16.9%). Average milk yield did not differ between the groups; instead, milk fat (8.39 vs. 9.06%; P cultivation is adversely affected by the high cost of irrigation.

  15. Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low protein diet

    Science.gov (United States)

    Malnutrition during the fetal growth period increases risk for later obesity and type 2 diabetes mellitus (T2DM). We have shown that a prenatal low protein (8% protein; LP) diet followed by postnatal high fat (45% fat; HF) diet results in offspring propensity for adipose tissue catch-up growth, obes...

  16. Evaluating the Impact of Six Supplemental Nutrition Assistance Program Education Interventions on Children's At-Home Diets

    Science.gov (United States)

    Williams, Pamela A.; Cates, Sheryl C.; Blitstein, Jonathan L.; Hersey, James C.; Kosa, Katherine M.; Long, Valerie A.; Singh, Anita; Berman, Danielle

    2015-01-01

    Background: Nutrition education in the Supplemental Nutrition Assistance Program Education (SNAP-Ed) is designed to promote healthy eating behaviors in a low-income target population. Purpose: To evaluate the effectiveness of six SNAP-Ed interventions delivered in child care centers or elementary school settings in increasing participating…

  17. 大学生饮食健康与营养教育研究%The Research of the Students' Healthy Diet and Nutrition Education

    Institute of Scientific and Technical Information of China (English)

    焦慧杰; 宋倩; 王冠宇

    2012-01-01

    With the development of social and economic, there have been some bad problems in the food consumption be- havior of college students:such as eating unbalanced, eating unhealthy, deterioration of physical health and so on. Although the educational administrative departments and experts have concerned about the these phenomena, but the problem have not caused the attention of contemporary college students. Now the solution to the problem is Implementing nutrition education for college students.The nutrition education not ony enable students to establish the science of awareness of proper diet,but alao enable students to develop the reasonable eating habits.%社会的发展和生活经济条件提高的同时,当代大学生在饮食消费行为上也出现了一些不良的问题:饮食不均衡,饮食不卫生,体质健康水平下降等。这些现象虽引起有关教育行政部门和专家的关注,但是并没有引起当代大学生的重视。目前解决这一问题的方法是对大学生进行营养教育,使大学生树立学合理饮食的意识,养成良好的饮食习惯。

  18. High levels of whole raw soya beans in dairy cow diets: digestibility and animal performance.

    Science.gov (United States)

    Barletta, R V; Gandra, J R; Freitas Junior, J E; Verdurico, L C; Mingoti, R D; Bettero, V P; Benevento, B C; Vilela, F G; Rennó, F P

    2016-12-01

    The aim of this study was to evaluate the effects of high levels of whole raw soya beans in the diets of lactating cows. Twelve Holstein dairy cows were used, randomized in three 4 ×  4 balanced and contemporary Latin squares and fed the following diets: (i) control (C), without including whole raw soya beans; (ii) 80 g/kg in DM of whole raw soya beans (G80); (iii) 160 g/kg in DM of whole raw soya beans (G160); and (iv) 240 g/kg in DM of whole raw soya beans (G240). There was significant reduction (p soya beans in dairy cow diets improves the unsaturated fatty acid profile in milk, and the diets (G80 and G160) led to minor alterations in the digestive processes and animal metabolism. Journal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbH.

  19. STUDY OF PREVALENCE OF THYROID DYSFUNCTION IN TYPE 2 DM IN RURAL POPULATION

    Directory of Open Access Journals (Sweden)

    Nanjil Kumaran

    2015-08-01

    Full Text Available Thyroid disease and diabetes are the two common endocrine disorders encountered in the clinical practice. Type 2 DM is a growing problem in our country and we have observed that many patients are associated with thyroid dysfunction later in their life. The aim of the study is to investigate the prevalence of thyroid dysfunction in patients with Type 2 DM in rural population. METHODS AND MATERIALS : A total of 100 patients attending diabetic clinic in Rajah Muthiah Medical College and Hospital were enrolled in the study and were randomized into test and control groups.70 Type 2 DM patients aged more than 18 years of both genders, Type II DM was diagnosed as pati ents who initially respond to OHA were included in the test group. Patient with thyroid dysfunction, Type 1 DM, chronic kidney disease were excluded. 30 Patients age matched control group without any history of diabetes and thyroid disease was taken for the study. RESULTS : In this study abnormal thyroid function was seen in 17 patients of Type 2 DM and remaining had normal thyroid function. The study shows prevalence of thyroid dysfunction is more in males compared with females. 10 out of 29 (34.4% males had thyroid dysfunction compared with that 7 out of 41 (17% females are suffering from thyroid dysfunction. CONCLUSION : There is growing evidence of an association between thyroid dysfunction and diabetes. Our study shows that higher prevalence of abnormal thyroid hormone levels in Type 2 DM.

  20. Investigation of the interaction of deltamethrin (DM) with human serum albumin by multi-spectroscopic method

    Science.gov (United States)

    Wang, Jiaman; Ma, Liang; Zhang, Yuhao; Jiang, Tao

    2017-02-01

    The interaction of Deltamethrin (DM) with human serum albumin (HSA) under the condition of simulating human blood pH environment (pH = 7.4) was investigated by fluorescence, UV-Vis absorbance and circular dichroism (CD) spectroscopy. It was shown that DM was a static quencher of HSA. The binding constants (Ka) are 3.598 × 104 L mol-1 (25 °C); the thermodynamic parameters (ΔH = -3.269 × 104 kJ mol-1, ΔS = -22.81 kJ mol-1 k-1, ΔG = -25889.8 kJ mol-1) obtained with the thermodynamic equation. The hydrogen bond and Vander Waals were the main driving force. The effect of DM on the conformation of HSA was observed by three-dimensional (3D) fluorescence and circular dichroism spectra, indicating that the interaction between DM and HSA was achieved through the binding of DM with the tryptophan and tyrosine residues of HSA. The study on the interaction of DM and Bovine Serum Albumin (BSA) was researched and compared. Difference exists in the interactions of with each of the serum albumins. We will verify and supplement that DM residue in animals and human metabolism, toxicology and other mechanisms are different.

  1. Reduced expression of the normal DMPK allele in a congenital DM patient

    Energy Technology Data Exchange (ETDEWEB)

    Funanage, V.L.; Carango, P.; Moses, R.M.; Marks, H.G. [Alfred I. duPont Institute, Wilmington, DE (United States)

    1994-09-01

    Both adult-onset and congenital myotonic dystrophy (DM) are autosomal dominant disorders caused by triplet repeat expansions within the 3{prime} untranslated region of the DM protein kinase (DMPK) gene. The size of the repeat region shows a positive correlation with disease severity; in general, the triplet repeat expansions in congenital DM patients are larger than those found in adult DM individuals. In an adult DM patient, the expanded allele of 133 repeats reduced both the synthesis and processing of DMPK mRNA, whereas expression from the unexpanded allele remained unaffected. However, in both muscle and skin tissues from a congenital DM individual, DMPK mRNA expression from the unexpanded allele was also reduced. This reduced expression was maintained in fibroblasts cultured from a skin biospy of the patient; however, normal expression of the unexpanded allele occurred in cultured myoblasts established from this patient`s muscle biopsy. To determine if the expanded repeat exerts a trans effect on DMPK gene expression, we have separated the normal and mutant DMPK alleles from the cogenital DM skin fibroblasts by somatic cell hybridization. Hybrid clones containing only the normal DMPK gene still produced reduced levels of DMPK mRNA, indicating that the reduced expression from the normal allele is due to a cis effect. Cultured skin fibroblasts from the congenital DM patient were exposed to 5-azacytidine to determine if demethylation of the DMPK gene could restore proper expression of the normal allele. We are currently analyzing DMPK mRNA levels in these cells and determining if a difference in the methylation patterns of the normal DMPK alleles from adult and congenital DM patients accounts for this effect.

  2. [Study of a DNA sequence from brine shrimp artemia containing a novel DM domain].

    Science.gov (United States)

    Zeng, Hui; Song, Wen Qin; Chen, Rui Yang

    2004-10-01

    Sex-determining mechanisms are highly variable between phyla. However, there is an apparent exception in which structurally and functionally related genes control sex determination in different phyla: the sexual regulators DSX of Drosophila melanogaster and MAB-3 of Caenorhabditis elegans both containing a DNA-binding motif, DM domain. Proteins containing the domain may also play a role in sexual development of vertebrates. For examples, both the human DMRT1 (doublesex and mab-3 related transcription factor 1) gene and mouse Dmrt1 gene are necessary for male development. In this paper, through the degenerated PCR, a DNA fragment ADM was amplified out from genomic DNA of brine shrimp, Artemia sinica from YunCheng Salt Lake, Shanxi, China and Artemia parthenogenetica from GaHai, Qinghai, China, respectively. ADM encodes 47 amino acids and is highly homologous to amino acid sequence of the known DM domains. By comparing total of 27 DM domains in distant related species, a phylogenic tree of DM domain was constructed. In the tree, these DM domains were divided into different branches according to their subtypes. Among the DM domains that were compared, ADM is most homologous to the DM domain contained in human DMRT3 and mouse Dmrt3, which shares 83% identity between them. In addition, the same length of ADM could also be amplified out from cDNA of Artemia sinica and Artemia parthenogenetica, which indicated that ADM was expressed and located in one exon. The DM domain in brine shrimp reported here would make it possible for cloning the full-length cDNA containing the DM domain and further elucidating their functions.

  3. Dm5-HT2B: Pharmacological Characterization of the Fifth Serotonin Receptor Subtype of Drosophila melanogaster

    Directory of Open Access Journals (Sweden)

    Wolfgang Blenau

    2017-05-01

    Full Text Available Serotonin (5-hydroxytryptamine, 5-HT is an important regulator of physiological and behavioral processes in both protostomes (e.g., insects and deuterostomes (e.g., mammals. In insects, serotonin has been found to modulate the heart rate and to control secretory processes, development, circadian rhythms, aggressive behavior, as well as to contribute to learning and memory. Serotonin exerts its activity by binding to and activating specific membrane receptors. The clear majority of these receptors belong to the superfamily of G-protein-coupled receptors. In Drosophila melanogaster, a total of five genes have been identified coding for 5-HT receptors. From this family of proteins, four have been pharmacologically examined in greater detail, so far. While Dm5-HT1A, Dm5-HT1B, and Dm5-HT7 couple to cAMP signaling cascades, the Dm5-HT2A receptor leads to Ca2+ signaling in an inositol-1,4,5-trisphosphate-dependent manner. Based on sequence similarity to homologous genes in other insects, a fifth D. melanogaster gene was uncovered coding for a Dm5-HT2B receptor. Knowledge about this receptor’s pharmacological properties is very limited. This is quite surprising because Dm5-HT2B has been attributed to distinct physiological functions based on genetic interference with its gene expression. Mutations were described reducing the response of the larval heart to 5-HT, and specific knockdown of Dm5-HT2B mRNA in hemocytes resulted in a higher susceptibility of the flies to bacterial infection. To gain deeper understanding of Dm5-HT2B’s pharmacology, we evaluated the receptor’s response to a series of established 5-HT receptor agonists and antagonists in a functional cell-based assay. Metoclopramide and mianserin were identified as two potent antagonists that may allow pharmacological interference with Dm5-HT2B signaling in vitro and in vivo.

  4. Apparent digestibility of simplified and semi-simplified diets, with and without addition of enzymes, and nutritional value of fibrous sources for rabbits

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Machado

    2012-07-01

    Full Text Available The objectives of this study were to evaluate the digestibility of the nutrients of simplified and semi-simplified diets, with and without inclusion of exogenous enzymes and to determine the nutritional value of the fibrous sources. The tested feedstuffs were: alfalfa hay, hay from the upper third of the cassava foliage and cassava leaf meal, using a completely randomized design with 11 diets and 8 repetitions. The treatments were constituted of 1 reference diet, 2 simplified diets and 8 semi-simplified diets (4 enzymatic inclusion. The enzymes used were carbohydrases (alpha-galactosidase, galactomanose, xylanase and beta glucanase and phytase. It was observed that the digestibility of the nutrients of the diets was influenced by the type of feed studied. Semi-simplified diets presented coefficients inferior to the reference diet and superior to the simplified diets. Exogenous enzymes promoted improvements in the digestibility of the dry matter (DM, organic matter, crude protein and gross energy. It was also observed that great part of the crude protein of the cassava leaf meal complexed, which depreciated the digestibility of diets with high inclusion of this ingredient. The nutritional value of fibrous sources was 1822.7 kcal digestible energy - DE/kgDM and 122,6 g digestible protein - DP/kg DM, for the hay from the upper third of the cassava foliage; 2232.5 kcalDE/kgDM and 155.4 gDP/kgDM for alfalfa hay and 1888.9 kcalDE/kgDM and 73.6 gDP/kgDM for the cassava leaf meal. With the exception of diets with elevated inclusion of cassava leaf meal, the semi-simplified diets presented satisfactory coefficients of digestibility improved by the enzymatic inclusion.

  5. [Diet low in potassium].

    Science.gov (United States)

    Sáez Rodríguez, Loreto; Meizoso Ameneiro, Ana; Pérez Paz, Ma Jesús; Valiño Pazos, Cristina

    2011-11-01

    After confirming the high prevalence rates in our hemodialysis unit of the following nursing diagnoses: nutritional imbalances--both excesses and shortages, willingness to improve nutrition and fear related to the consequences of excessive intake of potassium and manifested by the inhibition in some people towards the enjoyment of food, we decided to plan an educational strategy which later resulted in a nursing intervention for these diagnoses, with the objective of providing adequate resources for the monitoring of balanced diets with a restriction of potassium. Inspired by dietary rations, as well as recognized dietary programs of learning by points, we decided to incorporate these ideas to design an educational tool to facilitate advice to our patients on how to follow diet plans as well as the choice of appropriate foods. The result was a set of cards incorporating nutritional information of various kinds, aimed at our patients covering different aspects of the diet appropriate food rations using household measurements, promoting good food preparation, appropriate dietary advice for different chronic diseases and a scoring system of foods according to their potassium content. Together they form a board game available during the hemodialysis sessions that also takes into consideration other issues of importance related to conditions such as cognitive stimulation, coping with the disease, improving the therapeutic performance or resources to increase patient motivation. Although initially it was only an educational exercise, the result has turned out to be both enjoyable and entertaining.

  6. Comparison of three instructional strategies in food and nutrition education: developing a diet plan for a diabetic case

    Science.gov (United States)

    Darabi, Aubteen; Pourafshar, Shirin; Suryavanshi, Rinki; `Logan'Arrington, Thomas

    2016-05-01

    This study examines the performance of dietitians-in-training on developing a diet plan for a diabetic patient either independently or after peer discussion. Participants (n = 58) from an undergraduate program in food and nutrition were divided into two groups based on their prior knowledge before being randomly assigned into three conditions: (1) peer discussion with just-in-time information (JIT information), (2) peer discussion without JIT information), and (3) independent performers. The learners' performance in the three conditions was analyzed. The results presented here describe the role of prior knowledge and JIT information across the conditions and the interaction of the two factors as well as the instructional implications of the findings.

  7. Myotonic dystrophy type 1 (DM1): a triplet repeat expansion disorder.

    Science.gov (United States)

    Kumar, Ashok; Agarwal, Sarita; Agarwal, Divya; Phadke, Shubha R

    2013-06-15

    Myotonic dystrophy is a progressive multisystem genetic disorder affecting about 1 in 8000 people worldwide. The unstable repeat expansions of (CTG)n or (CCTG)n in the DMPK and ZNF9 genes cause the two known subtypes of myotonic dystrophy: (i) myotonic dystrophy type 1 (DM1) and (ii) myotonic dystrophy type 2 (DM2) respectively. There is currently no cure but supportive management helps equally to reduce the morbidity and mortality and patients need close follow up to pay attention to their clinical problems. This review will focus on the clinical features, molecular view and genetics, diagnosis and management of DM1.

  8. Qualidade de vida e sintomas depressivos em adolescentes com Diabetes Mellitus tipo 1 (DM1)

    OpenAIRE

    Gabriela de Oliveira Pintar

    2015-01-01

    O objetivo geral deste trabalho foi avaliar a presença de sintomas depressivos e as possíveis influências do Diabetes Mellitus tipo I (DM1) na qualidade de vida de adolescentes com esta doença. Para alcançar tal objetivo foram avaliados adolescentes com DM1 (58) e sem DM1 (61) completando um total de 119 adolescentes avaliados; de ambos os sexos. Os locais de coleta de dados foram o Ambulatório de Endocrinologia da Criança e do Adolescente (ECA) do Hospital das Clínicas da Faculdade de Medici...

  9. Studies on the s_dm.t=f verb form in Classical Egyptian

    OpenAIRE

    Zonhoven, Ludovicus Martinus Johannes

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance with present common opinion the sDm.t=f is here considered to belong to the suffix conjugation. Ch. I is primarily concerned with the active Dr sDm.t=f construction, but begins with a general introd...

  10. Vegan Diets and Hypothyroidism

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    Serena Tonstad

    2013-11-01

    Full Text Available Diets eliminating animal products have rarely been associated with hypothyroidism but may protect against autoimmune disease. Thus, we investigated whether risk of hypothyroidism was associated with vegetarian compared to omnivorous dietary patterns. The Adventist Health Study-2 was conducted among church members in North America who provided data in a self-administered questionnaire. Hypothyroidism was queried at baseline in 2002 and at follow-up to 2008. Diet was examined as a determinant of prevalent (n = 4237 of 65,981 [6.4%] and incident cases (1184 of 41,212 [2.9%] in multivariate logistic regression models, controlled for demographics and salt use. In the prevalence study, in addition to demographic characterstics, overweight and obesity increased the odds (OR 1.32, 95% CI: 1.22–1.42 and 1.78, 95% CI: 1.64–1.93, respectively. Vegan versus omnivorous diets tended to be associated with reduced risk (OR 0.89, 95% CI: 0.78–1.01, not statistically significant while a lacto-ovo diet was associated with increased risk (OR 1.09, 95% CI: 1.01–1.18. In the incidence study, female gender, white ethnicity, higher education and BMI were predictors of hypothyroidism. Following a vegan diet tended to be protective (OR 0.78, 95% CI: 0.59–1.03, not statistically significant. In conclusion, a vegan diet tended to be associated with lower, not higher, risk of hypothyroid disease.

  11. 基于DM365的便携监控系统解决方案%PortabIe Monitoring System SoIution Based on DM365

    Institute of Scientific and Technical Information of China (English)

    桑赫; 林岩; 张烽

    2015-01-01

    本文提出了一种基于TMS320 DM365芯片的便携监控系统解决方案。设计以 TMS320 DM365为核心硬件设备,在满足基本功能的基础上,尽量减小体积、降低功耗。编写了基于嵌入式 Linux系统的应用程序,完成了音频/视频采集、存储等功能,并设计了有效的电源管理方案,实现了便携监控系统与 Android手机间的数据交互,提升了该系统的易用性。%A portable monitoring system based on TMS320DM365 chip is proposed.The design takes TMS320DM365 as the core of the hardware devices,it minimizes the size and the power consumption as possible while satisfying the basic functions.The collection and storage of audio/video,effective power management scheme and data exchange between portable monitoring device and Android mobile phone are realized through writing application programs based on the embedded Linux system,so the usability of the system is enhanced.

  12. PI3K-GLUT4 Signal Pathway Associated with Effects of EX-B3 Electroacupuncture on Hyperglycemia and Insulin Resistance of T2DM Rats

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    Bing-Yan Cao

    2016-01-01

    Full Text Available Objectives. To explore electroacupuncture’s (EA’s effects on fasting blood glucose (FBG and insulin resistance of type 2 diabetic mellitus (T2DM model rats and give a possible explanation for the effects. Method. It takes high fat diet and intraperitoneal injection of streptozotocin (STZ, 30 mg/kg for model preparation. Model rats were randomly divided into T2DM Model group, EA weiwanxiashu (EX-B3 group, and sham EA group (n=12/group. EA (2 Hz continuous wave, 2 mA, 20 min/day, 6 days/week, 4 weeks was applied as intervention. FBG, area under curve (AUC of oral glucose tolerance test (OGTT, insulin resistance index (HOMA-IR, pancreatic B cell function index (HOMA-B, skeletal muscle phosphorylated phosphatidylinositol-3-kinase (PI3K, glucose transporter 4 (GLUT4, and membrane GLUT4 protein expression were measured. Results. EA weiwanxiashu (EX-B3 can greatly upregulate model rat’s significantly reduced skeletal muscle PI3K (Y607 and membrane GLUT4 protein expression (P<0.01, effectively reducing model rats’ FBG and AUC of OGTT (P<0.01. The effects are far superior to sham EA group. Conclusion. EA weiwanxiashu (EX-B3 can upregulate skeletal muscle phosphorylated PI3K protein expression, to stimulate membrane translocation of GLUT4 and thereby increase skeletal muscle glucose intake to treat T2DM.

  13. PI3K-GLUT4 Signal Pathway Associated with Effects of EX-B3 Electroacupuncture on Hyperglycemia and Insulin Resistance of T2DM Rats

    Science.gov (United States)

    2016-01-01

    Objectives. To explore electroacupuncture's (EA's) effects on fasting blood glucose (FBG) and insulin resistance of type 2 diabetic mellitus (T2DM) model rats and give a possible explanation for the effects. Method. It takes high fat diet and intraperitoneal injection of streptozotocin (STZ, 30 mg/kg) for model preparation. Model rats were randomly divided into T2DM Model group, EA weiwanxiashu (EX-B3) group, and sham EA group (n = 12/group). EA (2 Hz continuous wave, 2 mA, 20 min/day, 6 days/week, 4 weeks) was applied as intervention. FBG, area under curve (AUC) of oral glucose tolerance test (OGTT), insulin resistance index (HOMA-IR), pancreatic B cell function index (HOMA-B), skeletal muscle phosphorylated phosphatidylinositol-3-kinase (PI3K), glucose transporter 4 (GLUT4), and membrane GLUT4 protein expression were measured. Results. EA weiwanxiashu (EX-B3) can greatly upregulate model rat's significantly reduced skeletal muscle PI3K (Y607) and membrane GLUT4 protein expression (P < 0.01), effectively reducing model rats' FBG and AUC of OGTT (P < 0.01). The effects are far superior to sham EA group. Conclusion. EA weiwanxiashu (EX-B3) can upregulate skeletal muscle phosphorylated PI3K protein expression, to stimulate membrane translocation of GLUT4 and thereby increase skeletal muscle glucose intake to treat T2DM. PMID:27656242

  14. Effects of Clear Kefir on Biomolecular Aspects of Glycemic Status of Type 2 Diabetes Mellitus (T2DM Patients in Bandung, West Java [Study on Human Blood Glucose, c Peptide and Insulin

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    Judiono J

    2014-08-01

    Full Text Available Background: Diabetes Mellitus (DM triggers an excessive reaction of free-radicals. It increases reactive oxygen species and reduces antioxidants status as well as the β cell damage. Clear kefir was used for DM therapies, however it limited biomolecular exploration of its bioactive roles. Research aimed to investigate the effects of clear kefir on the biomolecular nature of the glycemic status of T2DM in Bandung. Methods: The randomized pretest-posttest control group was conducted by 106 T2DM patients. Research was done in several hospitals in Bandung and Cimahi, West Java from 2012–2013. Samples were divided randomly into three groups: (1 T2DM with HbA1c 7 fed standard diet and supplemented 200 ml/day by clear kefir, (3 T2DM with HbA1c was fed a standard diet as a control group. Dose response was obtained from a preeliminary vivo study, and then converted to human dosage by year 2011. Intervention was effectively done for 30 days. HbA1c was measured by HPLC. Fasting blood glucose (FBG and Postprandial blood glucose levels (PBG were measured by enzymes levels. C Peptide and insulin were measured by Elisa. Data was analyzed by a statictics programme by significance p<0,05. Study was approved by ethic committee. Results : HbA1c was significantly reduced in delta level (p<0.01 and FBG (p<0.015 among kefir groups. PBG was not significantly reduced among groups. C-Peptide was significantly increased in delta level, except in control group (p<0.014. Insulin was reduced significantly, except in control group (p<0.003. Conclusions : Supplementation of clear kefir reduced blood glucose levels (HbA1c, FBG, PBG and increased c-peptide. Clear kefir’s biomolecular mechanisms and chemistry characterization is a challenge for future studies.

  15. A very low-carbohydrate, low-saturated fat diet for type 2 diabetes management: a randomized trial.

    Science.gov (United States)

    Tay, Jeannie; Luscombe-Marsh, Natalie D; Thompson, Campbell H; Noakes, Manny; Buckley, Jon D; Wittert, Gary A; Yancy, William S; Brinkworth, Grant D

    2014-11-01

    To comprehensively compare the effects of a very low-carbohydrate, high-unsaturated/low-saturated fat diet (LC) with those of a high-unrefined carbohydrate, low-fat diet (HC) on glycemic control and cardiovascular disease (CVD) risk factors in type 2 diabetes (T2DM). Obese adults (n = 115, BMI 34.4 ± 4.2 kg/m(2), age 58 ± 7 years) with T2DM were randomized to a hypocaloric LC diet (14% carbohydrate [fat [saturated fat]) or an energy-matched HC diet (53% carbohydrate, 17% protein, and 30% fat [saturated fat]) combined with structured exercise for 24 weeks. The outcomes measured were as follows: glycosylated hemoglobin (HbA1c), glycemic variability (GV; assessed by 48-h continuous glucose monitoring), antiglycemic medication changes (antiglycemic medication effects score [MES]), and blood lipids and pressure. A total of 93 participants completed 24 weeks. Both groups achieved similar completion rates (LC 79%, HC 82%) and weight loss (LC -12.0 ± 6.3 kg, HC -11.5 ± 5.5 kg); P ≥ 0.50. Blood pressure (-9.8/-7.3 ± 11.6/6.8 mmHg), fasting blood glucose (-1.4 ± 2.3 mmol/L), and LDL cholesterol (-0.3 ± 0.6 mmol/L) decreased, with no diet effect (P ≥ 0.10). LC achieved greater reductions in triglycerides (-0.5 ± 0.5 vs. -0.1 ± 0.5 mmol/L), MES (-0.5 ± 0.5 vs. -0.2 ± 0.5), and GV indices; P ≤ 0.03. LC induced greater HbA1c reductions (-2.6 ± 1.0% [-28.4 ± 10.9 mmol/mol] vs. -1.9 ± 1.2% [-20.8 ± 13.1 mmol/mol]; P = 0.002) and HDL cholesterol (HDL-C) increases (0.2 ± 0.3 vs. 0.05 ± 0.2 mmol/L; P = 0.007) in participants with the respective baseline values HbA1c >7.8% (62 mmol/mol) and HDL-C saturated fat may be an effective dietary approach for T2DM management if effects are sustained beyond 24 weeks. © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  16. Glycerin and essential oils in the diet of Nellore bulls finished in feedlot: animal performance and apparent digestibility

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    Lorrayny Galoro da Silva

    2014-05-01

    Full Text Available Current research studied the effect of partial replacing corn by glycerin and essential oils addition in the diet of Nellore bulls finished in feedlot on feed intake, animal performance and three markers were assessed to estimate apparent digestibility. Thirty bulls with average weight 400 ± 34.1 kg and 22 ± 2 months old were housed in collective pens (10 x 20 m2 for 63 days. The bulls were randomly assigned to 3 diets (10 bulls per treatment: CON – Control (without glycerin or Essential® oils; GLY – Glycerin (15% on dry matter - DM; and GEO – Glycerin (15% on DM and Essential® oils (3 g animal day-1. Three different markers were used to estimate apparent digestibility in the diets: indigestible dry matter –iDM; indigestible neutral detergent fiber – iNDF; and purified lignin – LIPE®. Feed efficiency and animal performance were not affected by the corn partial replacing by glycerin. No effects were found in partial corn replacing by glycerin and Essential® oils addition in the diets on the fecal output, crude protein and ether extract digestibility among the diets. The DM and OM apparent digestibility were higher for bulls fed with glycerin and Essential® oils. The CHO digestibility was higher for CON diet. The markers iDM, iNDF and LIPE® were similarly to estimate apparent digestibility to all nutrients in the diets.

  17. Effect of corn bran and steep inclusion in finishing diets on diet digestibility, cattle performance, and nutrient mass balance.

    Science.gov (United States)

    Sayer, K M; Buckner, C D; Erickson, G E; Klopfenstein, T J; Macken, C N; Loy, T W

    2013-08-01

    One metabolism trial and 2 finishing trials were conducted to evaluate the effects of adding corn bran and steep liquor (steep) in replacement of dry-rolled corn (DRC) on diet digestibility, cattle performance, and nutrient mass balance in open feedlot pens. The metabolism trial (Exp. 1) used 8 ruminally cannulated heifers in a 4 × 4 Latin square design and the 2 finishing trials used 128 steer calves fed for 167 d (Exp. 2) and 256 yearling steers fed for 126 d (Exp. 3). Dietary treatments for all trials included a DRC-based control (CON), 30% corn bran (30/0), 30% corn bran plus 15% steep (30/15), and 45% corn bran plus 15% steep (45/15), in which by-products replaced DRC and molasses in the diet (DM basis). Diets were not isonitrogenous or isoenergetic. In the metabolism trial, feeding the by-product diets produced greater rumen pH (5.95) than CON (5.76; P diets (P diet than the by-product diets (2.36 vs. 2.84 and 0.72 vs. 1.66, respectively). In the performance trials, steers fed the by-product diets consumed more DM (P = 0.06) and G:F was either similar for all diets in Exp. 2 (P = 0.56) or less for cattle fed 30/0 than the other diets in Exp. 3 (P = 0.05). Percent N loss was reduced in Exp. 2 by including corn bran in diets compared with CON (P diet digestibility, it was beneficial in maintaining cattle performance in the feedlot studies. Feeding corn bran in combination with steep increased manure N removed and N in compost, but decreased percent N lost during the winter months only.

  18. Ingestive behavior of lambs fed diets containing castor seed meal.

    Science.gov (United States)

    Nicory, Isis Miranda Carvalho; de Carvalho, Gleidson Giordano Pinto; Ribeiro, Ossival Lolato; Silva, Robério Rodrigues; Tosto, Manuela Silva Libanio; Costa-Lopes, Lívia Santos; Souza, Fábio Nicory Costa; de Oliveira Nascimento, Camila

    2015-06-01

    The objective of this study was to evaluate the substitution of soybean meal for castor seed meal (CSM) in diets for feedlot lambs and the effects of these diets on their ingestive behavior. Fifty male Santa Inês lambs were used. The diets were composed of Tifton 85 hay and a concentrate containing detoxified CSM substituting 0, 25, 50, 75, or 100 % of the soybean meal. There was no effect (P > 0.05) of the CSM levels on the feeding, rumination, idle times, chews and time spent chewing per bolus, total chewing time, number of boli chewed, and number of chews per day. The dry matter (DM) intake decreased linearly (P  0.05) the numbers of feeding, rumination, and idle periods, but had a quadratic effect (P time per feeding activity and on the chewing periods. Substitution of soybean meal for detoxified CSM reduces the DM intake but does not change the ingestive behavior.

  19. Nutritional status of students of primary and secondary education of Valencia and the relationship with adherence to the Mediterranean Diet

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    Maria Navarro-Solera

    2014-06-01

    Full Text Available Introduction: Childhood obesity is reaching very high in the Spanish pediatric population favouring obesity in adults. To know the nutritional status of students from six schools in the province of Valencia and its degree of adherence to the Mediterranean Diet (MD.Material and methods: Cross-sectional study that included 777 students, 49.9% were boys and 50.1% girls aged between 8 and 16 years. Weight and height of each participant was determined and body mass index (BMI was calculated. From the Z-score BMI was calculated. KIDMED test was used to study the degree of adherence to the MD.Results: The prevalence of overweight was 14.5 % and 10.0% obese. A total of 53.3%, 30.1% and 16.6% of the whole sample showed a high, medium and low adherence to the MD, respectively. Age, sex and nutritional status were evaluated according to the adherence to the MD. Chi-squared analysis indicated significant association between academic course and nutritional status with the adherence to the MD. Being older and having a higher BMI supposed lower adherence to the MD.Conclusions: We confirmed that the adherence to the MD has significant association with the nutritional status of young people, worsening with increasing age. These results corroborate the need to re-learn eating habits.

  20. Sodium in diet

    Science.gov (United States)

    Diet - sodium (salt); Hyponatremia - sodium in diet; Hypernatremia - sodium in diet; Heart failure - sodium in diet ... The body uses sodium to control blood pressure and blood volume. Your body also needs sodium for your muscles and nerves to work ...

  1. Diet and Spondylitis

    Science.gov (United States)

    ... Have Spondylitis? Treatment Information Medications Exercise & Posture Diet & Nutrition Medication & Diet Dietary Supplements Changing Your Diet The London AS / Low Starch Diet Complementary Treatments Possible Complications Iritis or Anterior Uveitis Fatigue in Spondylitis Pain in ...

  2. The impact of low-carbohydrate diet on glycemic control in Native Americans

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    Khairi S

    2015-08-01

    Full Text Available Shafaq Khairi,1 Babak Torabi Sagvand,2 Syed Kamal Nasser3 1Southeastern Regional Physician Services, Lumberton, NC, 2Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Southeastern Regional Medical Center, Lumberton, NC, USA Abstract: Many studies have shown that a low-carbohydrate diet (LCD is a safe and effective intervention to improve glycemic control. However, published data are limited regarding the use of carbohydrate restriction in the treatment and prevention of type 2 diabetes mellitus (DM in the Native Americans, in a real-world clinical practice setting. We evaluated the efficacy of an LCD on 50 obese Native Americans with either type 2 DM or impaired fasting blood glucose (IFG in a primary care/obesity medicine practice. The primary intervention was an LCD defined as an intake of <20 g of carbohydrates per day. The intervention involved providing an educational handout and behavioral counseling assisted by a dedicated weight loss coordinator. We evaluated the effects of this intervention on hemoglobin A1c, body weight, blood pressure, and lipid parameters. The subjects were evaluated at baseline and 6 months. The subjects underwent additional safety and counseling visits throughout the study. Subjects were considered completers if they had baseline and 6-month measurements. The mean age was 55.0±10.9 years, and 66.7% were female. Subjects had significant improvements in hemoglobin A1c (-1.4%±0.9%, in subjects with DM, P<0.0001, fasting blood glucose (-15±4.9 mg/dL, in subjects with IFG, P<0.0001, and body mass index (-4.0±1.7 kg/m2, P<0.0001. An LCD can lead to clinically and statistically significant improvement in glycemic control and body weight among obese subjects with type 2 DM or IFG over a 6-month period. The results suggest that carbohydrate restriction can be an effective real-world intervention in a primarily Native American clinical practice. However, further studies are needed

  3. The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance.

    Science.gov (United States)

    Dai, Bing; Wu, Qinxuan; Zeng, Chengxi; Zhang, Jiani; Cao, Luting; Xiao, Zizeng; Yang, Menglin

    2016-11-04

    Liuwei Dihaung decoction (LWDHT) is a well-known classic traditional Chinese medicine formula, consists of six herbs including Rehmannia glutinosa Libosch.(family: Scrophulariaceae), Cornus officinalis Sieb.(family: Cornaceae), Dioscorea opposite Thunb.(family: Dioscoreaceae), Alisma orientale(G. Samuelsson) Juz (family: Alismataceae), Poria cocos (Schw.) Wolf (family: Polyporaceae) and Paeonia suffruticosa Andrews (family: Paeoniaceae). It has been used in the treatment of many types of diseases with signs of deficiency of Yin in the kidneys in China clinically. This study is aimed at investigating the effect of Liuwei dihuang decoction on PI3K/Akt signaling pathway in liver of T2DM rats with insulin resistance. T2DM model was induced in male Sprague-Dawley (SD) rats by high sugar and high fat diets combined with small dose of streptozocin (STZ) injection. The successful T2DM rats were randomly allocated three group--vehicle group, positive control group and Liuwei Dihuang decoction group. After 12-weeks treatment with distilled water, rosiglitazone and LWDHT by intragastric administration respectively, the rats were put to death in batches. The variance of fasting blood glucose (FBG) and fasting insulin (FINS) in serum were determined, the pathological changes of each rats' liver were observed by hematoxylin-eosin (HE) staining, the expression of insulin receptor substrate 2(IRS2), phosphatidylinositol 3-kinase (PI3K) and protein kinas B (Akt) involving the canonical PI3K/Akt signaling pathway were detected by Real-time fluorescent quantitative PCR (RT-PCR), and the expression level of IRS2, PI3K, Akt protein and phosphorylated IRS2, PI3K, Akt protein were evaluated by Western Blot. All the data were analyzed by SPSS 17.0. Four weeks of treatment with LWDHT could significantly decrease the level of FBG and FINS in serum, improve the cellular morphology of liver, kidney, pancreas tissue, and the expression of IRS2, PI3K, Akt mRNA and phosphorylated IRS2, PI3K, Akt

  4. Are socioeconomic disparities in diet quality explained by diet cost?

    Science.gov (United States)

    Monsivais, Pablo; Aggarwal, Anju; Drewnowski, Adam

    2014-01-01

    Background Socioeconomic disparities in nutrition are well documented. This study tested the hypothesis that socioeconomic differences in nutrient intakes can be accounted for, in part, by diet cost. Methods A representative sample of 1,295 adults in King County (WA) was surveyed in 2008–2009 and usual dietary intakes were assessed based on a food frequency questionnaire (FFQ). Monetary value of individual diets was estimated using local retail supermarket prices for 384 foods. Nutrients of concern as identified by the 2005 Dietary Guidelines Advisory Committee were fiber, vitamins A, C and E, calcium, magnesium and potassium. A nutrient density score based on all seven nutrients was another dependent measure. General linear models and linear regressions were used to examine associations among education and income, nutrient density measure and diet cost. Analyses were conducted in 2009–2010. Results Controlling for energy and other covariates, higher-cost diets were significantly higher in all seven nutrients and in overall nutrient density. Higher education and income were positively and significantly associated with the nutrient density measure, but these effects were greatly attenuated with the inclusion of the cost variable in the model. Conclusions Socioeconomic differences in nutrient intake can be substantially explained by the monetary cost of the diet. The higher cost of more nutritious diets may contribute to socioeconomic disparities in health and should be taken into account in the formulation of nutrition and public health policy. PMID:21148819

  5. [Osteoporosis diet].

    Science.gov (United States)

    Morselli, B; Neuenschwander, B; Perrelet, R; Lippuner, K

    2000-03-01

    Bone requires a wide variety of nutrients to develop normally and to maintain itself after growth. Most important--in the sense that bony abnormalities are associated with their deficiencies--are protein, calcium, phosphorus, vitamin D, C and K, zinc, manganese and copper. The nutrients most likely to be deficient in citizens of industrialized countries are calcium and vitamin D. In this review of the current literature about nutritional aspects of osteoporosis, we have focused on factors influencing calcium requirement: the principal interacting nutrients are sodium, protein, caffeine, fiber, oxalate, phytate, and the acid/alkaline ash character of the overall diet. Fiber and caffeine decrease calcium absorption from the gut and typically exert relatively minor effects, while sodium, protein and the acid/alkaline balance of the diet increase urinary excretion of calcium and are of much greater significance for the calcium homeostasis. Alkali buffers, whether vegetables or fruits reverse this urinary calcium loss. As long as accompanied by adequate calcium intake, protein-rich diet is not deleterious to bone: a calcium-to-protein ratio of 20:1 (mg calcium/g protein) is recommended. Whether a nutrition-based therapeutic approach to osteoporosis is feasible in the near future is yet unclear: at least there are some recent promising data from in-vitro as well as from rat studies showing that extracts taken from various vegetables, mainly from the onion family inhibit bone resorption in a dose-dependent manner.

  6. Methane emissions from feedlot cattle fed barley or corn diets.

    Science.gov (United States)

    Beauchemin, K A; McGinn, S M

    2005-03-01

    Methane emitted from the livestock sector contributes to greenhouse gas emissions worldwide. Understanding the variability in enteric methane production related to diet is essential to decreasing uncertainty in greenhouse gas emission inventories and to identifying viable greenhouse gas reduction strategies. Our study focused on measuring methane in growing beef cattle fed corn- or barley-based diets typical of those fed to cattle in North American feedlots. The experiment was designed as a randomized complete block (group) design with two treatments, barley and corn. Angus heifer calves (initial BW = 328 kg) were allocated to two groups (eight per group), with four cattle in each group fed a corn or barley diet. The experiment was conducted over a 42-d backgrounding phase, a 35-d transition phase and a 32-d finishing phase. Backgrounding diets consisted of 70% barley silage or corn silage and 30% concentrate containing steam-rolled barley or dry-rolled corn (DM basis). Finishing diets consisted of 9% barley silage and 91% concentrate containing barley or corn (DM basis). All diets contained monensin (33 mg/kg of DM). Cattle were placed into four large environmental chambers (two heifers per chamber) during each phase to measure enteric methane production for 3 d. During the backgrounding phase, DMI was greater by cattle fed corn than for those fed barley (10.2 vs. 7.6 kg/d, P cattle were in the chambers; thus, methane emissions (g/d) reported may underestimate those of the feedlot industry. Methane emissions per kilogram of DMI and as a percentage of GE intake were not affected by grain source during the backgrounding phase (24.6 g/kg of DMI; 7.42% of GE), but were less (P methane emissions of cattle fed high-forage backgrounding diets and barley-based finishing diets. Mitigating methane losses from cattle will have long-term environmental benefits by decreasing agriculture's contribution to greenhouse gas emissions.

  7. Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.

    Directory of Open Access Journals (Sweden)

    Lise Michel

    Full Text Available Myotonic dystrophy type 1 (DM1 is caused by an unstable expanded CTG repeat located within the DMPK gene 3'UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among which the congenital form (CDM is the most severe. Molecular mechanisms of DM1 are well characterized for the adult form and involve accumulation of mutant DMPK RNA forming foci in the nucleus. These RNA foci sequester proteins from the MBNL family and deregulate CELF proteins. These proteins are involved in many cellular mechanisms such as alternative splicing, transcriptional, translational and post-translational regulation miRNA regulation as well as mRNA polyadenylation and localization. All these mechanisms can be impaired in DM1 because of the deregulation of CELF and MBNL functions. The mechanisms involved in CDM are not clearly described. In order to get insight into the mechanisms underlying CDM, we investigated if expanded RNA nuclear foci, one of the molecular hallmarks of DM1, could be detected in human DM1 fetal tissues, as well as in embryonic and neonatal tissues from transgenic mice carrying the human DMPK gene with an expanded CTG repeat. We observed very abundant RNA foci formed by sense DMPK RNA and, to a lesser extent, antisense DMPK RNA foci. Sense DMPK RNA foci clearly co-localized with MBNL1 and MBNL2 proteins. In addition, we studied DMPK sense and antisense expression during development in the transgenic mice. We found that DMPK sense and antisense transcripts are expressed from embryonic and fetal stages in heart, muscle and brain and are regulated during development. These results suggest that mechanisms underlying DM1 and CDM involved common players including toxic expanded RNA forming numerous nuclear foci at early stages during development.

  8. Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole.

    Directory of Open Access Journals (Sweden)

    Alessandro Achilli

    Full Text Available Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM. Additionally, rare mitochondrial DNA (mtDNA mutations have been shown to be causal for T2DM pathogenesis. So far, many studies have investigated the possibility that mtDNA variation might affect the risk of T2DM, however, when found, haplogroup association has been rarely replicated, even in related populations, possibly due to an inadequate level of haplogroup resolution. Effects of mtDNA variation on diabetes complications have also been proposed. However, additional studies evaluating the mitochondrial role on both T2DM and related complications are badly needed. To test the hypothesis of a mitochondrial genome effect on diabetes and its complications, we genotyped the mtDNAs of 466 T2DM patients and 438 controls from a regional population of central Italy (Marche. Based on the most updated mtDNA phylogeny, all 904 samples were classified into 57 different mitochondrial sub-haplogroups, thus reaching an unprecedented level of resolution. We then evaluated whether the susceptibility of developing T2DM or its complications differed among the identified haplogroups, considering also the potential effects of phenotypical and clinical variables. MtDNA backgrounds, even when based on a refined haplogroup classification, do not appear to play a role in developing T2DM despite a possible protective effect for the common European haplogroup H1, which harbors the G3010A transition in the MTRNR2 gene. In contrast, our data indicate that different mitochondrial haplogroups are significantly associated with an increased risk of specific diabetes complications: H (the most frequent European haplogroup with retinopathy, H3 with neuropathy, U3 with nephropathy, and V with renal failure.

  9. Research on application of the novel food exchange serving based on glycemic load in the diet education for type 2 diabetes%两种饮食干预方法对2型糖尿病疗效比较

    Institute of Scientific and Technical Information of China (English)

    金敬红; 吕探云; 王君俏; 白姣姣; 高键

    2009-01-01

    Objective To explore the effectiveness of the novel food exchange serving based on glycemic load in the diet education for type 2 diabetes.Methods Seventy-two cases of type 2 diabetes were 1randomly divided into two groups to receive either a novel food exchange serving based on glycemic load (the test group) or a food exchange serving (the control group) education,by the forms of group education,individual education and DM patients′salon.The period lasted three months.Fasting blood glucose(FBG),2h postprandial blood glucose(2 hPBG), glycosylated hemoglobin(HbA1c),and blood lipids which include total cholesterol(TC),triglycerides(TG),body mass index(BMI), waist circumference (WC),blood pressure(BP) were assessed.Results FBG(P<0.05)、2hPBG(P<0.01)、HbA1c(P<0.05)、TC(P<0.05)and BMI(P<0.05)in the test education group were all significantly decreased than that of the control group.Conclusion The application of food exchange serving based on glycemic load in the diet education for type 2 diabetes is better than that of conventional food exchange serving,and worthy of further practice and popularization.%目的 探讨基于血糖负荷的食物交换份法用于2型糖尿病患者饮食教育的有效性.方法 随机抽取上海市某三级甲等医院糖尿病门诊2型糖尿病患者72例,随机分为实验组与对照组,每组各36例.实验组采用基于血糖负荷的食物交换份法,对照组采用传统的食物交换份法,通过多种方式实施3个月的饮食教育干预.于干预后3个月,随访3个月时进行干预效果的评价.结果 实验组与对照组餐后空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇水平和体质指数的差异具有统计学意义(P<0.05及P<0.01).结论 基于血糖负荷的食物交换份法用于2型糖尿病患者的饮食教育较传统的食物交换份法更有效,值得应用与推广.

  10. 糖尿病患者饮食教育的研究现状探讨%Study on the Current Situation of Diet Education in Patients with Diabetes Mellitus

    Institute of Scientific and Technical Information of China (English)

    李俊

    2015-01-01

    Objective To investigate the current status of diet education in patients with diabetes and the importance of diet education in the diagnosis and treatment of diabetes mellitus. Methods According to the basic principles of the diet of pa-tients with diabetes, 102 patients with diabetic inpatients in our hospital from June 2015 to June 2014 were selected. The patients were treated with various forms and methods to guide and nursing, and then compared and analyzed some of the test parameters of the diet before and after treatment. Results Patients with diabetes after receiving the diet education can be a good grasp of the relevant knowledge, the average rate of 95%, and the correlation of the test indicators and the diet before treatment significantly decreased, P<0.05, has statistical significance. Conclusion In the treatment of patients with diabetes, diet education is one of the basic methods, not only can play a certain role in the disease, but also can improve the quality of life of patients with diabetes, it is worth clinical promotion.%目的 探讨糖尿病患者饮食教育的研究现状以及饮食教育在糖尿病患者诊治中的重要性. 方法 根据糖尿病患者饮食的基本原则,选取2014年6月—2015年6月该院收治的糖尿病住院患者共102例,对这些患者利用多种形式和方法进行饮食方面的指导和护理,然后将饮食治疗前后的一些检验指标进行对比和分析. 结果 糖尿病患者在接受饮食教育之后能够很好的掌握相关知识,掌握率平均达到了95%以上,并且相关的检验指标和饮食治疗之前相比明显下降,P<0.05,差异有统计学意义. 结论 在治疗糖尿病患者的方法中,饮食教育是基本的方法之一,不仅可以对病情起到一定的控制作用,而且还可以提高糖尿病患者的生活质量,值得临床推广.

  11. Dimethoate-induced oxidative damage in erythrocytes of female adult rats: possible protective effect of vitamin E and selenium supplemented to diet.

    Science.gov (United States)

    Ben Amara, Ibtissem; Soudani, Nejla; Hakim, Ahmed; Bouaziz, Hanen; Troudi, Afef; Zeghal, Khaled Mounir; Zeghal, Najiba

    2012-04-01

    Pesticide hazards have been accentuated by the sharp rise in their agricultural, industrial and domestic use. Acute exposure to pesticides can cause oxidative damage. Our study investigated the potential ability of selenium (Se) and/or vitamin E, used as nutritional supplements, to alleviate erythrocyte oxidative damage induced by dimethoate (DM), an organophosphate pesticide. Female Wistar rats were exposed to DM (0.2g/L(-1) of drinking water), DM + Se (0.5 mg/kg of diet), DM + vitamin E (100 mg/kg of diet), or DM + Se + vitamin E. Rats exposed to DM for 30 days showed an increase in malondialdehyde levels, superoxide dismutase and glutathione peroxidase activities in their erythocytes, while Na(+),K(+)-ATPase and catalase activities, glutathione, non-protein thiol, vitamin E and vitamin C levels decreased. We also noted an increase in lactate dehydrogenase activity, marker of haemolysis and a decrease in acetylcholinesterase, the principal mode of organophosphorus action. Co-administration of Se or vitamin E to the diet of DM-treated rats ameliorated the biochemical parameters cited above. But the combined effect of Se and vitamin E was more powerful in antagonizing DM-induced oxidative stress. Therefore, our investigation revealed that both Se and vitamin E were useful elements in preventing DM-induced erythrocytes damage.

  12. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus

    OpenAIRE

    Goday Arno, Alberto; D. Bellido; Sajoux, I; Crujeiras, A. B.; Burguera, B.; García-Luna, Pedro Pablo; Oleaga, A.; Moreno, B.; Casanueva, Felipe F.

    2016-01-01

    Brackground:The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients.OBJECTIVE: Evaluating the short-term safety and tolerability of a VLCK diet (

  13. The value of Leucaena leucocephala bark in leucaena-grass hay diets for Thai goats.

    Science.gov (United States)

    Palmer, Brian; Jones, Raymond J; Poathong, Somsak; Chobtang, Jeerasak

    2010-12-01

    The study assessed the value of Leucaena leucocephala bark in leucaena-grass hay diets fed to Thai goats. Thai goats in metabolism pens were fed diets containing leucaena leaf (55%) + pangola grass hay (hay, 45%); leucaena leaf (48%) + leucaena bark (9%) + hay (43%); leucaena bark (57%) + hay (43%); and hay only. Feed percentages are expressed on a dry weight basis. The digestibilities of dry matter (DM) and crude protein (CP) were measured for the four diets. Leucaena bark had lower CP concentration than the leaf (11.7 vs. 25.9), and the leucaena bark + hay diet had lower DM and CP digestibility than the other diets. The calculated bark digestibilities of DM and CP of 44.1% and 38.2%, respectively, were much lower than the values for the leucaena leaf of 62.9% and 89.1%, respectively. The lower than expected CP digestibility was attributed to higher tannin levels in the bark compared to the leaves. Despite this, the bark was well accepted by the goats and was often preferred to the hay. Stripping of the bark by goats also results in stems that dry quicker and have higher calorific value as fuel. However, if leucaena branches are fed as a sole diet, the goats may consume up to 30% of bark on a DM basis and this would reduce nutritive value and animal productivity.

  14. Microstructure evolution and kinetic analysis of DM hot-work die steels during tempering

    Energy Technology Data Exchange (ETDEWEB)

    Zhou Qingchun, E-mail: qingchun@shu.edu.cn [School of Materials Science and Engineering, Shanghai University, Shanghai 200072 (China); Wu Xiaochun; Shi Nannan; Li Junwan; Min Na [School of Materials Science and Engineering, Shanghai University, Shanghai 200072 (China)

    2011-07-15

    Highlights: {yields} Hardness of the DM steels decreases continuously with increasing temperature. {yields} Increasing temperatures results in intra-lath carbides precipitate and coarsen significantly. {yields} The values of n indicate a growth mechanism in coarsening of large spheroids on dislocations. {yields} Mn in DM steels dissolves into carbides and retards the coarsening of carbides at high temperature. - Abstract: Utilizing the hardness measurement, an attempt is made to study the tempering kinetics of DM hot-work die steels, combined with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results demonstrate that the increasing of tempering temperature will result in precipitation and coarsening of the intra-lath spherical carbides. Meanwhile, it is significantly observed the dissolution of needle-like Mo2C carbides with increasing of tempering temperatures. The growth mechanism of carbides is coarsening of large spheroids after complete and impingement precipitation on dislocations. In addition, the activation energy {Delta}H of DM steels during additional tempering between 620 deg. C and 700 deg. C is slightly higher than that of the diffusion of usual alloying elements (e.g. Cr, V, Mo and W) in ferrite, which may be attributed to a higher Mn content in DM steels that dissolves into carbides and retardsthe coarsening of carbides at high temperature.

  15. Complementarity of DM searches in a consistent simplified model: the case of Z{sup ′}

    Energy Technology Data Exchange (ETDEWEB)

    Jacques, Thomas [SISSA and INFN,via Bonomea 265, 34136 Trieste (Italy); Katz, Andrey [Theory Division, CERN,CH-1211 Geneva 23 (Switzerland); Département de Physique Théorique and Center for Astroparticle Physics (CAP),Université de Genève, 24 quai Ansermet, CH-1211 Genève 4 (Switzerland); Morgante, Enrico; Racco, Davide [Département de Physique Théorique and Center for Astroparticle Physics (CAP),Université de Genève, 24 quai Ansermet, CH-1211 Genève 4 (Switzerland); Rameez, Mohamed [Département de Physique Nucléaire et Corpusculaire,Université de Genève, 24 quai Ansermet, CH-1211 Genève 4 (Switzerland); Riotto, Antonio [Département de Physique Théorique and Center for Astroparticle Physics (CAP),Université de Genève, 24 quai Ansermet, CH-1211 Genève 4 (Switzerland)

    2016-10-14

    We analyze the constraints from direct and indirect detection on fermionic Majorana Dark Matter (DM). Because the interaction with the Standard Model (SM) particles is spin-dependent, a priori the constraints that one gets from neutrino telescopes, the LHC, direct and indirect detection experiments are comparable. We study the complementarity of these searches in a particular example, in which a heavy Z{sup ′} mediates the interactions between the SM and the DM. We find that for heavy dark matter indirect detection provides the strongest bounds on this scenario, while IceCube bounds are typically stronger than those from direct detection. The LHC constraints are dominant for smaller dark matter masses. These light masses are less motivated by thermal relic abundance considerations. We show that the dominant annihilation channels of the light DM in the Sun and the Galactic Center are either bb̄ or tt̄, while the heavy DM annihilation is completely dominated by Zh channel. The latter produces a hard neutrino spectrum which has not been previously analyzed. We study the neutrino spectrum yielded by DM and recast IceCube constraints to allow proper comparison with constraints from direct and indirect detection experiments and LHC exclusions.

  16. Complementarity of DM Searches in a Consistent Simplified Model: the Case of Z'

    CERN Document Server

    Jacques, Thomas; Morgante, Enrico; Racco, Davide; Rameez, Mohamed; Riotto, Antonio

    2016-01-01

    We analyze the constraints from direct and indirect detection on fermionic Majorana Dark Matter (DM). Because the interaction with the Standard Model (SM) particles is spin-dependent, a priori the constraints that one gets from neutrino telescopes, the LHC and direct detection experiments are comparable. We study the complementarity of these searches in a particular example, in which a heavy $Z'$ mediates the interactions between the SM and the DM. We find that in most cases IceCube provides the strongest bounds on this scenario, while the LHC constraints are only meaningful for smaller dark matter masses. These light masses are less motivated by thermal relic abundance considerations. We show that the dominant annihilation channels of the light DM in the Sun are either $b \\bar b$ or $t \\bar t$, while the heavy DM annihilation is completely dominated by $Zh$ channel. The latter produces a hard neutrino spectrum which has not been previously analyzed. We study the neutrino spectrum yielded by DM and recast Ice...

  17. Routine daily physical activity and glucose variations are strongly coupled in adults with T1DM.

    Science.gov (United States)

    Farabi, Sarah S; Carley, David W; Cinar, Ali; Quinn, Lauretta

    2015-12-01

    Type 1 Diabetes (T1DM) is characterized by altered glucose homeostasis resulting in wide glucose variations throughout a 24-h period. The relationship between routine daily physical activity and glucose variations has not been systematically investigated in adults with T1DM. The objectives of this study were to characterize and quantify the relationship between routine daily activity and glucose variations in a small group of adults with T1DM. Adults with T1DM treated with an insulin pump were recruited for the study. Over a 3-day period, glucose variations were monitored with a continuous glucose monitoring system (CGMS) and routine daily physical activity was assessed using an accelerometer-based physical activity-monitoring band. Simultaneous glucose and physical activity data for one 24-h period were used for analysis. Cross-correlation function and wavelet coherence analyses were employed to quantify the coupling between physical activity and glucose. Twelve subjects were included in the analysis. Cross-correlation function analysis revealed strong coupling between activity and glucose. Wavelet Coherence demonstrated that slower oscillations (120-340 min) of glucose and physical activity exhibited significantly greater coherence (F = 12.6, P < 0.0001) than faster oscillations (10 and 120 min). Physical activity and glucose demonstrate strong time and frequency-dependent coupling throughout a 24-h time period in adults with T1DM.

  18. Influence of diet on gut microbiota, inflammation and type 2 diabetes mellitus. First experience with macrobiotic Ma-Pi 2 diet.

    Science.gov (United States)

    Fallucca, Francesco; Porrata, Carmen; Fallucca, Sara; Pianesi, Mario

    2014-03-01

    Type 2 diabetes mellitus (T2DM) is a complex disorder influenced by both genetic and environmental factors. Recent studies have suggested that an imbalance of the intestinal microbiota may be involved in the development of several human diseases, including obesity and T2DM. The main regulators of the intestinal microbiota are age, ethnicity, the immune system and diet. A high-fat diet may induce dysbiosis, which can result in a low-grade inflammatory state, obesity and other metabolic disorders. Adding prebiotics to the diet may reduce inflammation, endotoxaemia and cytokine levels as well as improving insulin resistance and glucose tolerance. The administration of prebiotics such as fermentable dietary fibres, promotes glucagon-like peptide 1 and peptide YY (anorexigenic) and decreases ghrelin (orexigenic). In a recent 21-day, intervention study in patients with T2DM, the effect of using the macrobiotic Ma-Pi 2 diet was investigated. Results suggested that it could induce a significant improvement in fasting blood glucose, plasma lipid fractions, plasma insulin and homeostasis. It is therefore possible that a diet rich in prebiotics and probiotics can play a role in T2DM management, probably due to positive intestinal microbiota modulation. However, this must be demonstrated by larger studies including randomized controlled trials that measure indicators of inflammation.

  19. Replacing single-view mediolateral oblique (MLO) digital mammography (DM) with synthesized mammography (SM) with digital breast tomosynthesis (DBT) images: Comparison of the diagnostic performance and radiation dose with two-view DM with or without MLO-DBT.

    Science.gov (United States)

    Kang, Hyo-Jin; Chang, Jung Min; Lee, Joongyub; Song, Sung Eun; Shin, Sung Ui; Kim, Won Hwa; Bae, Min Sun; Moon, Woo Kyung

    2016-11-01

    To evaluate the diagnostic performance and radiation dose of single view cranio-caudal (CC) digital mammography (DM) plus mediolateral oblique (MLO) digital breast tomosynthesis (DBT) combined with synthesized mammography (SM) in comparison with two-view DM with or without DBT. This study was approved by our institutional review board, and informed consent was obtained from 130 women. Paired two-view DM and single MLO-DBT with SM images were acquired, and four independent retrospective reading sessions of different combinations of DM, SM and DBT were performed for the presence of malignant tumors using jackknife alternative free-response receiver operator curve (JAFROC) methods. The diagnostic performances and average glandular dose (AGD) were compared between different combinations of DM, SM and DBT. Of 159 lesions in 130 patients, 27 were malignant. When using MLO-DBT with SM instead of MLO-DM, a significantly higher sensitivity (P=0.016) and specificity (P=0.012) were noted than with two-view DM, and comparable figure of merit (FOM), sensitivity, and specificity to two-view DM with DBT were noted. The mean AGD of CC-DM plus MLO-DBT with SM was 5.78mGy±1.06 per patient, which was significantly lower than that with two-view DM with MLO-DBT (8.45mGy±1.32; P <0.001) and slightly higher than that with two-view DM (5.30mGy±0.63). The combined use of CC-DM plus MLO-DBT with SM showed higher sensitivity and specificity to two-view DM with a smaller AGD increment and comparable diagnostic performance to that of two-view DM with MLO-DBT with a significantly lower mean AGD. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing

    OpenAIRE

    Andrea Ferrante; Jack Gorski

    2012-01-01

    The mechanism of HLA-DM (DM) activity is still unclear. We have shown that DM-mediated peptide release from HLA-DR (DR) is dependent on the presence of exchange peptide. However, DM also promotes a small amount of peptide release in the absence of exchange peptide. Here we show that SDS-PAGE separates purified peptide/DR1 complexes (pDR1) into two conformers whose ratio is peptide K d-dependent. In the absence of exchange peptide, DM only releases peptide from the slower migrating conformer. ...

  1. Feeding motivation and plasma metabolites in pregnant sows fed diets rich in dietary fiber either once or twice daily

    DEFF Research Database (Denmark)

    Jensen, Margit Bak; Pedersen, Lene Juul; Theil, Peter Kappel

    2012-01-01

    The present study investigated the effects of source and level of dietary fiber (DF) and feeding frequency (once vs. twice daily) on feeding motivation and plasma metabolites at 4 different time points post feeding. Sixty pregnant sows (Sus scrofa, 4 blocks of 15 sows) were allocated to 1 of 5...... diets within blocks. Four diets were restricted (approximately 35 MJ ME/d): a barley and wheat control diet (171 g DF/kg DM; 12 g DF/MJ ME), and 3 fiber diets formulated to contain 35% DF by including pectin residue (323 g DF/kg DM; 25 g DF/MJ ME), potato pulp (404 g DF/kg DM; 29 g DF/MJ ME), or sugar...... beet pulp (367 g DF/kg DM; 25 g DF/MJ ME). The fifth diet was a mixture including an equal amount of the 3 fiber diets offered semi ad libitum (ad libitum access to feed during 6 periods of 1 h starting at 0300, 0600, 1100, 1500, 1800, and 2300; 354 g DF/kg DM; 25 g DF/MJ ME). The experimental period...

  2. Dark matter, dark radiation and Higgs phenomenology in the hidden sector DM models

    CERN Document Server

    Ko, P

    2015-01-01

    I present a class of hidden sector dark matter (DM) models with local dark gauge symmetries, where DM is stable due to unbroken local dark gauge symmetry, or due topology, or it is long-lived because of some accidental symme- tries, and the particle contents and their dynamics are completely fixed by local gauge symmetries. In these models, one have two types of natural force mediators, dark gauge bosons and dark Higgs boson, which would affect DM and Higgs phenomenology in important ways. I discuss various phenomenological issues including the GeV scale gamma-ray excess from the galactic center (GC), (in)direct detection signatures, dark radiation, Higgs phenomenology and Higgs inflation assisted by dark Higgs.

  3. Separation and Purification of Total Phloroglucinols inDryopteris crassirhizoma with DM-130 Macroporous Adsorption Resin

    Institute of Scientific and Technical Information of China (English)

    Jin Zhe; Huang Jian-ping; Wang He-meng; Ju han-xun; Ren Si-rui; Chang Ying

    2015-01-01

    To improve the purity of the total phloroglucinols fromDryopteris crassirhizoma extracts, the separation and purification conditions of the total phloroglucinols fromDryopteris crassirhizoma were studied with DM-130 macroporous adsorption resin in this study. Adsorption rate, elution rate and purity of the total phloroglucinols were used as indexes to investigate the adsorption and desorption capacity of the total phloroglucinols with DM-130 macroporous adsorption resin. Through the study, the optimum sample concentration of the total phloroglucinols and maximum sample volume were 1.5 mg• mL-1 and 7 BV (210 mL), respectively. The optimum desorption conditions were achieved by using 80% ethanol as desorption solvent at elution flow rate of 1.0 mL• min-1. The result showed DM-130 macroporous adsorption resin performed effective adsorption and desorption. After purification, the purity of the total phloroglucinols increased by 11.5-fold.

  4. DM dimensioning for the next generation AO systems : strategies and rules

    Science.gov (United States)

    Costille, A.; Conan, J.-M.

    2007-07-01

    Adaptive optics (AO) provides a real time correction of turbulence and allows to improve the angular resolution of the astronomical telescopes. The design of AO systems and of its key components (deformable mirror (DM), wave-front sensors...) is very important to provide the best performance. The definition rules are well known for 10m class telescopes. However the study of the next generation of telescopes, especially the Extremely Large Telescope (ELT), associated with the development of new technological solutions, particularly concerning DMs, require to refine and in some cases to reconsider these rules. Both turbulent parameters (seeing, outer scale ...), telescope effects, system design and performance requirements have to be considered in order to define the DM key parameters (stroke, inter-actuator stroke, influence function ...). We present a study based on the combination of analytical expressions and numerical simulation results. We do not give absolute rules of design but we present key aspects to keep in mind when designing the DM.

  5. Feeding behavior of lambs fed diets containing peach palm meal

    Directory of Open Access Journals (Sweden)

    Alana Batista dos Santos

    2016-06-01

    Full Text Available The aim of this study was to evaluate the feeding behavior of lambs fed diets containing peach palm meal replacing maize (0, 10, 40, 60, and 85% DM. Thirty Santa Inês sheep with an average initial body weight of 21.6 ± 0.87 kg were distributed in a completely randomized design with five diets and six replicates. Feeding time in min kg–1 DM and min kg–1 NDFap increased by 34 min and 99.6 min, respectively, with each level of substitution of maize for the peach palm meal. Rumination and chewing times, in min kg–1 DM and min kg–1 NDF, also increased in response to the substitution of maize for peach palm meal. When expressed in min day–1, rumination and chewing activities decreased by 12.4 and 14.6 min, respectively, as the amount of peach palm meal in the concentrate was increased. The time spent idle increased linearly (P < 0.05, by 14.6 min day–1, with the replacement levels, compared with the control diet. Peach palm meal in the composition of sheep diets reduces the intakes of dry matter and fiber and decreases the feed and rumination efficiencies. Replacing maize by peach palm meal increases the feeding time and rumination and chewing activities of feedlot lambs.

  6. Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX.

    Directory of Open Access Journals (Sweden)

    Christian Mitri

    2009-06-01

    Full Text Available For all animals, the taste sense is crucial to detect and avoid ingesting toxic molecules. Many toxins are synthesized by plants as a defense mechanism against insect predation. One example of such a natural toxic molecule is L-canavanine, a nonprotein amino acid found in the seeds of many legumes. Whether and how insects are informed that some plants contain L-canavanine remains to be elucidated. In insects, the taste sense relies on gustatory receptors forming the gustatory receptor (Gr family. Gr proteins display highly divergent sequences, suggesting that they could cover the entire range of tastants. However, one cannot exclude the possibility of evolutionarily independent taste receptors. Here, we show that L-canavanine is not only toxic, but is also a repellent for Drosophila. Using a pharmacogenetic approach, we find that flies sense food containing this poison by the DmX receptor. DmXR is an insect orphan G-protein-coupled receptor that has partially diverged in its ligand binding pocket from the metabotropic glutamate receptor family. Blockade of DmXR function with an antagonist lowers the repulsive effect of L-canavanine. In addition, disruption of the DmXR encoding gene, called mangetout (mtt, suppresses the L-canavanine repellent effect. To avoid the ingestion of L-canavanine, DmXR expression is required in bitter-sensitive gustatory receptor neurons, where it triggers the premature retraction of the proboscis, thus leading to the end of food searching. These findings show that the DmX receptor, which does not belong to the Gr family, fulfills a gustatory function necessary to avoid eating a natural toxin.

  7. DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer.

    Science.gov (United States)

    Ghelardini, C; Galeotti, N; Gualtieri, F; Romanelli, M N; Bucherelli, C; Baldi, E; Bartolini, A

    2002-06-01

    DM235 (sunifiram), a new compound structurally related to piracetam, prevented the amnesia induced by scopolamine (1.5 mg kg(-1) i.p.), after intraperitoneal (0.001-0.1 mg kg(-1)) or oral (0.01-0.1 mg kg(-1)) administration, as shown by a passive avoidance test in mice. The antiamnesic effect of DM235 was comparable to that of well-known nootropic drugs such as piracetam (30-100 mg kg(-1) i.p.), aniracetam (100 mg kg(-1) p.o.) or rolipram (30 mg kg(-1) p.o.). DM235 also prevented mecamylamine (20 mg kg(-1) i.p.)-, baclofen (2 mg kg(-1) i.p.)- and clonidine (0.125 mg kg(-1) i.p.)-induced amnesia in the same test. In the Morris water maze test with rats, scopolamine (0.8 mg kg(-1) i.p.) inhibited the reduction of escape latency in both acquisition and retention/retraining tests. DM235 (0.1 mg kg(-1) i.p.), 20 min before each daily acquisition training, prevented the scopolamine-induced memory impairment. DM235 (1 mg kg(-1) i.p.) also reduced the duration of pentobarbitone-induced hypnosis in mice without modifying the induction time of hypnosis. At the highest effective doses, the investigated compound neither impaired motor coordination (rota-rod test), nor modified spontaneous motility and inspection activity (Animex and hole board tests). These results indicate that DM235, a compound structurally related to piracetam, is a novel nootropic endowed with the capability to prevent cognitive deficits at very low doses. Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds.

  8. Acceptability of a low-fat vegan diet compares favorably to a step II diet in a randomized, controlled trial.

    Science.gov (United States)

    Barnard, Neal D; Scialli, Anthony R; Turner-McGrievy, Gabrielle; Lanou, Amy J

    2004-01-01

    This study aimed to assess the acceptability of a low-fat vegan diet, as compared with a more typical fat-modified diet, among overweight and obese adults. Through newspaper advertisements, 64 overweight, postmenopausal women were recruited, 59 of whom completed the study. The participants were assigned randomly to a low-fat vegan diet or, for comparison, to a National Cholesterol Education Program Step II (NCEP) diet. At baseline and 14 weeks later, dietary intake, dietary restraint, disinhibition, and hunger, as well as the acceptability and perceived benefits and adverse effects of each diet were assessed. Dietary restraint increased in the NCEP group (P vegan group. Disinhibition and hunger scores fell in each group (P vegan group participants rated their diet as less easy to prepare than their usual diets (P vegan diet is high and not demonstrably different from that of a more moderate low-fat diet among well-educated, postmenopausal women in a research environment.

  9. Digestibility and nitrogen utilization in sheep fed enset (Ensete ventricosum) pseudostem or corm and graded levels of Desmodium intortum hay to wheat straw-based diets.

    Science.gov (United States)

    Nurfeta, A

    2010-12-01

    The aim of this study was to investigate the effects of different levels of Desmodium intortum (Desmodium) hay supplementation in sheep fed fixed amounts of enset pseudostem or corm and a basal diet of wheat straw on intake, digestibility and nitrogen utilization. Eighteen male sheep with a mean (± SD) live weight of 20.5 ± 1.45 kg were assigned to six treatments in a completely randomized design and fed either 108 g dry matter (DM) enset pseudostem or 165 g DM enset corm each with three levels (100, 200 and 300 g) of hay supplementation. For the pseudostem diets, there was no significant difference in total DM intake. Total crude protein (CP) intake and N retention increased with increasing levels of hay in both pseudostem and corm diets. The apparent digestibility of DM, OM, CP, acid detergent fibre and neutral detergent fibre (NDF) and microbial nitrogen supply (MN) at 100 g was lower that other levels of supplementation. For the corm diets, total DM and OM intake and MN supply increased with increasing levels of hay. The digestibility decreased (p Desmodium hay is required in pseudostem diets, whereas 200 g (337 g/kg dietary DM) may be sufficient in corm diets for efficient nutrient utilization.

  10. Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) & Type 2 Diabetes Mellitus (DM)

    OpenAIRE

    Shin, Hyun-Jong; Kim, Jae-ha; Yi, Joo-Hark; Han, Sang-Woong; Kim, Ho-Jung

    2012-01-01

    We report a rare case of the concurrent manifestation of central diabetes insipidus (CDI) and type 2 diabetes mellitus (DM). A 56 year-old man was diagnosed as a type 2 DM on the basis of hyperglycemia with polyuria and polydipsia at a local clinic two months ago and started an oral hypoglycemic medication, but resulted in no symptomatic improvement at all. Upon admission to the university hospital, the patient's initial fasting blood sugar level was 140 mg/dL, and he showed polydipsic and po...

  11. The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study

    Directory of Open Access Journals (Sweden)

    Yamakawa-Kobayashi Kimiko

    2012-02-01

    Full Text Available Abstract Background Type 2 diabetes mellitus (T2DM is a complex endocrine and metabolic disorder. Recently, several genome-wide association studies (GWAS have identified many novel susceptibility loci for T2DM, and indicated that there are common genetic causes contributing to the susceptibility to T2DM in multiple populations worldwide. In addition, clinical and epidemiological studies have indicated that obesity is a major risk factor for T2DM. However, the prevalence of obesity varies among the various ethnic groups. We aimed to determine the combined effects of these susceptibility loci and obesity/overweight for development of T2DM in the Japanese. Methods Single nucleotide polymorphisms (SNPs in or near 17 susceptibility loci for T2DM, identified through GWAS in Caucasian and Asian populations, were genotyped in 333 cases with T2DM and 417 control subjects. Results We confirmed that the cumulative number of risk alleles based on 17 susceptibility loci for T2DM was an important risk factor in the development of T2DM in Japanese population (P P P = 0.88 for trend. Conclusions Our findings indicate that there is an etiological heterogeneity of T2DM between obese/overweight and non-obese subjects.

  12. Diabetic Diet: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Diabetes and Diet (Academy of Nutrition and Dietetics) Diabetes and Nutrition (American Academy of Family Physicians) ... a Registered Dietitian Nutritionist (Academy of Nutrition and Dietetics) National Diabetes Education Program National Institute of Diabetes ...

  13. Sustaining Effect of Intensive Nutritional Intervention Combined with Health Education on Dietary Behavior and Plasma Glucose in Type 2 Diabetes Mellitus Patients.

    Science.gov (United States)

    Fan, Rui; Xu, Meihong; Wang, Junbo; Zhang, Zhaofeng; Chen, Qihe; Li, Ye; Gu, Jiaojiao; Cai, Xiaxia; Guo, Qianying; Bao, Lei; Li, Yong

    2016-09-13

    Diabetes mellitus is very common in elderly Chinese individuals. Although nutritional intervention can provide a balanced diet, the sustaining effect on at-home dietary behavior and long-term plasma glucose control is not clear. Consequently, we conducted a long-term survey following one month of experiential nutritional intervention combined with health education. Based on the Dietary Guidelines for a Chinese Resident, we found that the food items met the recommended values, the percentages of energy provided from fat, protein, and carbohydrate were more reasonable after one year. The newly formed dietary patterns were "Healthy", "Monotonous", "Vegetarian", "Japanese", "Low energy", and "Traditional" diets. The 2h-PG of female participants as well as those favoring the "Japanese diet" decreased above 12 mmol/L. Participants who selected "Japanese" and "Healthy" diets showed an obvious reduction in FPG while the FPG of participants from Group A declined slightly. "Japanese" and "Healthy" diets also obtained the highest DDP scores, and thus can be considered suitable for T2DM treatment in China. The results of the newly formed dietary patterns, "Japanese" and "Healthy" diets, confirmed the profound efficacy of nutritional intervention combined with health education for improving dietary behavior and glycemic control although health education played a more important role. The present study is encouraging with regard to further exploration of comprehensive diabetes care.

  14. 基于DM365的人脸检测系统的设计与实现%Design and implementation of human facedetection based on DM365

    Institute of Scientific and Technical Information of China (English)

    张健; 蒋挺

    2012-01-01

    随着安防、人机交互等需求的提出,人脸检测已经成为模式识别领域的一个研究热点,日益受到人们的重视。近年来,随着嵌入式系统的快速发展,出现了基于嵌入式设备的人脸检测系统,由于其具有体积小、成本低、布设方便的优点,逐渐得到了人们的青睐,所以取得了很大的发展。本文主要研究和开发了基于德州仪器DM365视频监控设备的人脸检测系统,针对 Adaboost 的人脸检测算法进行了研究,利用改进的带加权判决函数的级联分类器来提高检测准确率,并给出了在DM365嵌入式视频监控设备上的实现。%The face detection algorithm, currently, receives an increasing attention, and has become a hot topic in the field of the pattern recognition with the requirement of the security guards against theft and the human-computer interaction. With the rapid development of the embedded system, the face detection system based on embedded platform emerged in recent years. And this system has earned the favor of users and developed rapidly due to its advantages of tiny volume, low cost and convenient layout. In this paper, we researched and developed a face detection system based on DM365. The AdaBoost algorithm was improved by employing a cascade classifier with weighted decision function. This improved algorithm enhanced accuracy rate of the detection and was implemented on DM365.

  15. An embedded intelligent directed lessons recording system based on TI DM365%基于TI DM365的嵌入式智能导播录课系统

    Institute of Scientific and Technical Information of China (English)

    孙小期; 王晓东; 汤锐彬; 张婷; 刘家璇; 陈芬

    2015-01-01

    In recent years, with the launch of MOOC, Flipped Classroom and other online education products, the Internet is gradually changing the traditional way of teaching. The key factor of those online education products is recording quality , individualized teaching videos. This paper describes an embedded intelligent directed lessons recording system based on TI DM365 , which uses TI DM365 DSP chip receiving three-way video and two-way audio on hardware and provides USB , LAN and WiFi interfaces. Using FFmpeg open source library of advanced audio and video codec library libavcodec , the PC software of this system is developed by VS2013 C ++. The system has a multi-channel audio and video francis decoding, six kinds of intelligence directed and switch modes, local, cloud storage and on-demand playback functions. System test results show that the system performance is stable, the delay of audio and video is less than 100 ms and the recorded video resolution reaches 1080 p, which suggest sound quality is good. Compared with the existing lessons record mode, the system has a series of advantages such as simplicity, convenience, economization and humanization.%近年来,随着 MOOC、翻转课堂等在线教育产品的推出,互联网正渐渐改变着传统的教学方式,其关键因素在于优质、个性化教学视频的录制。本文介绍了一种基于 TI DM365芯片的嵌入式智能导播录课系统,硬件上采用 TI DM365 DSP 芯片接收3路视频和2路音频,并提供 USB、LAN及 WiFi 接口;软件上采用 FFmpeg 开源库中先进的音视频编解码库 libavcodec ,系统上位机软件基于VS2013 C++开发。该系统具有多路音、视频混流解码,六种智能导播和切换模式,本地、云端存储和点播回放等功能。系统测试结果表明:该系统性能稳定、音视频延时率小于100 ms ,所录制的视频的分辨率达到1080 p、音质效果佳。与现有的录课方式相比,本系统具有简

  16. EFFECTS OF MAIZE GRAIN ADDED IN A DIET BASED ON ALFALFA HAYLAGE ON THE RATION QUALITY IN WETHER SHEEP

    Directory of Open Access Journals (Sweden)

    Marina Vranić

    2011-06-01

    Full Text Available The objective of this experiment was to study the effects of interactions between alfalfa haylage (AH and maize grain (MG (5 vs. 10 g d-1 kg-1 body weight on ad libitum intake, water intake and dry matter (DM digestibility in wether sheep. The AH and MG contained 534.7 and 915.1g DM kg-1 fresh sample respectively, while crude protein (CP concentration was 141 and 106.0 g kg-1DM. Adding of MG (5 or 10 g kg-1 body weight d-1 into AH based ration resulted in linear increase in diet DM intake (g kg-1 M0,75, linear decrease in water intake (P<0.01 and linear increase in diet DM digestibility (P<0,001. A positive associative response of MG supplementation to AH based ration was observed for DM intake (P<0.001 and DM digestibility (P<0.001. No improvements in DM intake were recorded with 10 g MG added kg-1 body weight d-1 in comparison with 5 g MG added kg-1 body weight d-1.

  17. Gene structure and amino acid sequence of Latimeria chalumnae (coelacanth) myelin DM20: phylogenetic relation of the fish.

    Science.gov (United States)

    Tohyama, Y; Kasama-Yoshida, H; Sakuma, M; Kobayashi, Y; Cao, Y; Hasegawa, M; Kojima, H; Tamai, Y; Tanokura, M; Kurihara, T

    1999-07-01

    The structure of Latimeria chalumnae (coelacanth) proteolipid protein/DM20 gene excluding exon 1 was determined, and the amino acid sequence of Latimeria DM20 corresponding to exons 2-7 was deduced. The nucleotide sequence of exon 3 suggests that only DM20 isoform is expressed in Latimeria. The structure of proteolipid protein/DM20 gene is well preserved among human, dog, mouse, and Latimeria. Southern blot analysis indicates that Latimeria DM20 gene is a single-copy gene. When the amino acid sequences of DM20 were compared among various species, Latimeria was more similar to tetrapods than other fishes including lungfish, confirming the previous finding by immunoreactivity (Waehneldt and Malotka 1989 J. Neurochem. 52:1941-1943). However, when phylogenetic trees were constructed from the DM20 sequences, lungfish was clearly the closest to tetrapods. Latimeria was situated outside of lungfish by the maximum likelihood method. The apparent similarity of Latimeria DM20 to tetrapod proteolipid protein/DM20 is explained by the slow amino acid substitution rate of Latimeria DM20.

  18. Convergent myotonic dystrophy (DM) haplotypes on 19q13.3: Potential inconsistencies in human disease gene localization

    Energy Technology Data Exchange (ETDEWEB)

    Tsilfidis, C. [Eye Research Institute of Canada, Toronto (Canada); Whiting, E.J. [Univ. of Ottawa (Canada); Korneluk, R.G. [Univ. of Ottawa (Canada)]|[Childrens Hospital of Eastern Ontario, Ottawa (Canada)

    1994-09-01

    Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease which has been shown to be caused by an unstable trinucleotide repeat located on chromosome 19q. We have conducted extensive haplotype analysis on 103 DM chromosome using thirteen 19q13.3 loci identifying 18 RFLPs, spanning a physical distance of 1.3 Mb containing the myotonic dystrophy gene. Three major haplotypes, H1, H2 and H3, comprising 45.6% of the DM chromosomes, were observed in our population. The later two haplotypes, observed exclusively on DM chromosomes of French Canadian origin, contain a 500 kb core region that is identical. The low frequency of this core on normal chromosomes (0.8%) is consistent with a mapping of the DM gene within this region. However, the DM mutation is found 160 kb distal to the point of divergence between these two haplotypes. In contrast, the 450 kb shared by haplotypes H1 and H2 contain the DM mutation. Further, analysis of the DM region using a polymorphic microsatellite GJ-VSSM2 located 15 kb telomeric to the DM gene revealed strong allelic association of allele V on DM chromosomes (present on 6% of normal and 88.2% of DM chromosomes). The fact that allele V was found on all DM chromosomes with the three major haplotypes is indicative of their common origin and includes the two French Canadian haplotypes which share a region proximal to the DM mutation. This analysis indicates that convergent haplotypes, in the absence of a more extensive linkage disequilibrium analysis, may lead to a spurious disease gene localization.

  19. A STUDY ON PREVALENCE OF DM, HYPERTENSION AND ASSOCIATION WITH LIFE STYLE AS RISK FACTORS IN A RURAL POPULATION DISTRICT GHAZIABAD (U. P.

    Directory of Open Access Journals (Sweden)

    Narendra

    2014-12-01

    Full Text Available BACKGROUND & OBJECTIVE: Estimation of rising prevalence of Diabetes Mellitus, Hypertension, Obesity etc & association with various risk factors is having bearing on effective preventive programmes. Cross sectional study was conducted in rural population in a health centre to assess prevalence of DM, Hypertension, and association with their life style if any. METHODS: Pretested proforma administered to all males 35 -50 yrs age coming to a health Centre. Information on diets, habits, physical activity, medical & family history, height, weight, blood pressure, blood sugar level was taken. For data analyses epi info software used. RESULTS: Out of 1120 participants, 186 were having Hypertension, prevalence of 16.87%, 14 hypertensive, (7.53 % with positive family history of hypertension. 89 were Diabetic, prevalence of 7.94 %. In this group, 7 (7.90% had family history of diabetes. Overall 258 (25.03% had abnormal BMI, age group with highest BMI as risk factor, had higher hypertensive & Diabetics persons, most of them consuming non-vegetarian diet with saturated fats. Most of participants were doing mild to moderate physical activity. INTERPRETATION & CONCLUSIONS: The study provides insight on high burden, of Hypertension, Diabetes Mellitus, and the associated risk factors in a rural population in a health Centre. Life style modifications, more physical activity, lesser intake of non-vegetarian items, fats, salt in the diet, will result in lesser risk & load of these diseases.

  20. Data of evolutionary structure change: 1AIJL-2J8DM [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AIJL-2J8DM 1AIJ 2J8D L M -------------------ALLSFERKYRVPGGTLV--G...ment> 0 1AIJ L 1AIJ...788360596 8.022679328918457 1 1AIJ... L 1AIJL YGLGG-APLAK...line> GLU CA 293 ARG CA 280 1AIJ

  1. Discovery of Low DM Fast Radio Transients: Geminga Pulsar Caught in the Act

    CERN Document Server

    Maan, Yogesh

    2015-01-01

    We report discovery of several energetic radio bursts at 34 MHz, using the Gauribidanur radio telescope. The radio bursts exhibit two important properties associated with the propagation of astronomical signals through the interstellar medium: (i) frequency dependent dispersive delays across the observing bandwidth, and (ii) Faraday rotation of the plane of linear polarization. These bursts sample a range of dispersion measures (DM; 1.4--3.6$~{\\rm pc}~{\\rm cm}^{-3}$), and show DM-variation at timescales of the order of a minute. Using groups of bursts having a consistent DM, we show that the bursts have originated from the radio-quiet gamma-ray pulsar Geminga. Detection of these bursts supports the existence of occasional radio emission from Geminga. The rare occurrence of these bursts, and the short timescale variation in their DM (if really caused by the intervening medium or the pulsar magnetosphere), might provide clues as to why the pulsar has not been detected in earlier sensitive searches. We present d...

  2. Does the diffusion DM-DE interaction model solve cosmological puzzles?

    CERN Document Server

    Szydlowski, Marek

    2016-01-01

    We study dynamics of cosmological models with diffusion effects modeling dark matter and dark energy interactions. We show the simple model with diffusion between the cosmological constant sector and dark matter, where the canonical scaling law of dark matter $(\\rho_{dm,0}a^{-3}(t))$ is modified by an additive $\\epsilon(t)=\\gamma t a^{-3}(t)$ to the form $\\rho_{dm}=\\rho_{dm,0}a^{-3}(t)+\\epsilon(t)$. We reduced this model to the autonomous dynamical system and investigate it using dynamical system methods. This system possesses a two-dimensional invariant submanifold on which the DM-DE interaction can be analyzed on the phase plane. The state variables are density parameter for matter (dark and visible) and parameter $\\delta$ characterizing the rate of growth of energy transfer between the dark sectors. A corresponding dynamical system belongs to a general class of jungle type of cosmologies represented by coupled cosmological models in a Lotka-Volterra framework. We demonstrate that the de Sitter solution is ...

  3. Non-chiral fusion rules, structure constants of $D_{m}$ minimal models

    CERN Document Server

    Rida, A

    1999-01-01

    We present a technique to construct, for $D_{m}$ unitary minimal models, the non-chiral fusion rules which determines the operator content of the operator product algebra. Using these rules we solve the bootstrap equations and therefore determine the structure constants of these models. Through this approach we emphasize the role played by some discrete symmetries in the classification of minimal models.

  4. AMS02 positron excess from decaying fermion DM with local dark gauge symmetry

    Directory of Open Access Journals (Sweden)

    P. Ko

    2015-02-01

    Full Text Available Positron excess observed by PAMELA, Fermi and AMS02 may be due to dark matter (DM pair annihilation or decay dominantly into muons. In this paper, we consider a scenario with thermal fermionic DM (χ with mass ∼O(1–2 TeV decaying into a dark Higgs (ϕ and an active neutrino (νa instead of the SM Higgs boson and νa. We first present a renormalizable model for this scenario with local dark U(1X gauge symmetry, in which the DM χ can be thermalized by Higgs portal and the gauge kinetic mixing. Assuming the dark Higgs (ϕ mass is in the range 2mμDM can be enhanced to some extent, and three puzzles in the CDM paradigm can be somewhat relaxed.

  5. Effect of DM Actuator Errors on the WFIRST/AFTA Coronagraph Contrast Performance

    Science.gov (United States)

    Sidick, Erkin; Shi, Fang

    2015-01-01

    The WFIRST/AFTA 2.4 m space telescope currently under study includes a stellar coronagraph for the imaging and the spectral characterization of extrasolar planets. The coronagraph employs two sequential deformable mirrors (DMs) to compensate for phase and amplitude errors in creating dark holes. DMs are critical elements in high contrast coronagraphs, requiring precision and stability measured in picometers to enable detection of Earth-like exoplanets. Working with a low-order wavefront-sensor the DM that is conjugate to a pupil can also be used to correct low-order wavefront drift during a scientific observation. However, not all actuators in a DM have the same gain. When using such a DM in low-order wavefront sensing and control subsystem, the actuator gain errors introduce high-spatial frequency errors to the DM surface and thus worsen the contrast performance of the coronagraph. We have investigated the effects of actuator gain errors and the actuator command digitization errors on the contrast performance of the coronagraph through modeling and simulations, and will present our results in this paper.

  6. Studies on the s_dm.t=f verb form in Classical Egyptian

    NARCIS (Netherlands)

    Zonhoven, Ludovicus Martinus Johannes

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance

  7. Studies on the s_dm.t=f verb form in Classical Egyptian

    NARCIS (Netherlands)

    Zonhoven, Ludovicus Martinus Johannes

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance w

  8. Studies on the s_dm.t=f verb form in Classical Egyptian

    NARCIS (Netherlands)

    Zonhoven, Ludovicus Martinus Johannes

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance w

  9. Are Detox Diets Safe?

    Science.gov (United States)

    ... A Week of Healthy Breakfasts Shyness Are Detox Diets Safe? KidsHealth > For Teens > Are Detox Diets Safe? ... las dietas de desintoxicación? What Is a Detox Diet? The name sounds reassuring — everyone knows that anything ...

  10. Fluoride in diet

    Science.gov (United States)

    Diet - fluoride ... bones and teeth. Too much fluoride in the diet is very rare. Rarely, infants who get too ... of essential vitamins is to eat a balanced diet that contains a variety of foods from the ...

  11. Nutrition and Diet

    Science.gov (United States)

    ... Thai HbH:Vietnamese Relevant links Living with Thalassemia NUTRITION ▶ Nutrition and DietDiet for the Non-transfused ... Nutrition with Connie Schroepfer, MS, RD: Dec 2016 Nutrition and Diet Nutritional deficiencies are common in thalassemia, ...

  12. Lipoprotein (a, C-reactive protein and some metabolic cardiovascular risk factors in type 2 DM

    Directory of Open Access Journals (Sweden)

    Ogbera Anthonia O

    2010-07-01

    Full Text Available Abstract Background Lipoprotein (a (LP (a is an independent cardiovascular risk factor that is not widely studied in people of sub-Saharan African origin. The aim of this report is to determine the frequency of occurrence of elevated Lp (a and possible relationship with total cholesterol (TCHOL, high density lipoprotein cholesterol (HDL-C, low density lipoprotein cholesterol (LDL-C, triglycerides (TG, C reactive protein (CRP and serum uric acid (SUA. Methods This is a cross sectional study carried out in 200 Nigerian patients with type 2 DM and 100 sex and age matched healthy Controls aged between 32-86 years. We determined the frequency of occurrence of elevated Lp (a levels in the study subjects and compared clinical and biochemical variables between type 2 diabetic patients and non-diabetic patients. Clinical and biochemical parameters were also compared between subjects with type 2 DM who had elevated LP (a and normal LP (a levels. Long term glycaemic control using glycosylated haemoglobin was determined and compared in the study subjects. Test statistics used include chi square, correlation coefficient analysis and Student's t test. Results The mean Lp(a concentration differed significantly between type 2 diabetic patients and the Control subjects (18.7 (5.8 mg/dl vs 23 (6.8 mg/dl, 0.00001. Similarly, the prevalence of high LP (a levels in type 2 DM patients was significantly higher than that of the Control subjects (12.5% vs 4%, p-0.019. The mean levels of the lipid profile parameters (TCHOL, LDL-C, TG, LDL/HDL and CRP were significantly higher in DM patients than in the Control subjects. The mean LP (a levels were comparable in both sexes and in DM subjects with and without hypertension. TG was the only parameter that differed significantly between subjects with elevated Lp (a levels and those with normal Lp (a levels. There was a significant positive correlation (r between Lp(a levels and TG, LDL-C. TCHOL, LDL/HDL and uric acid. No

  13. Gut microbiota and Ma-Pi 2 macrobiotic diet in thetreatment of type 2 diabetes

    Institute of Scientific and Technical Information of China (English)

    Francesco Fallucca; Lucia Fontana; Sara Fallucca; Mario Pianesi

    2015-01-01

    In the past 10 years the prevalence of type 2 diabetesmellitus (T2DM) has increased hugely worldwide, driven bya rise in the numbers of overweight and obese individuals.A number of diets have been shown to be effective forthe management of T2DM the Mediterranean diet, thevegetarian diet and the low-calorie diet. Results of studiesclearly indicate, however, that the efficacy of these dietsis not solely related to the biochemical structure of theindividual nutrients they contain. This review discussesthis point with reference to the potential role of theintestinal microbiota in diabetes. The macrobiotic Ma-Pi 2diet is rich in carbohydrates, whole grains and vegetables,with no animal fat or protein or added sugar. In shortandmedium-term trials conducted in patients with T2DM,the Ma-Pi 2 diet has been found to significantly improveindicators of metabolic control, including fasting bloodglucose, glycosylated hemoglobin, the serum lipid profile,body mass index, body weight and blood pressure. Thediet may also alter the gut microbiota composition, whichcould additionally affect glycemic control. As a result, theMa-Pi 2 diet could be considered a valid additional shorttomedium-term treatment for T2DM.

  14. Survey on requirements of healthy diet education in comprehensive university%综合性高校健康饮食教育需求调查与分析

    Institute of Scientific and Technical Information of China (English)

    刘长征; 雷波

    2013-01-01

    目的 了解综合性高校学生健康饮食教育需求状况,分析其原因,为高校开展健康饮食教育提供参考.方法 采用自行设计的调查问卷,对江西省4所综合性高校837人进行问卷调查.结果 学生健康饮食知识需求前3位分别是:日常饮食误区、食品安全知识、食物的合理搭配;健康饮食知识获取途径需求前3位分别是:开展健康饮食讲座、开设健康饮食课程、网络;开展健康饮食教育途径需求前3位分别是:选修课、专题讲座、课外活动.结论 综合性高校学生健康饮食教育需求程度高,广大高校应针对性的迅速开展健康饮食教育,满足学生对健康饮食知识的需求.%OBJECTIVE To study requirements of healthy diet education in comprehensive university students.METHODS A questionnaire survey was conducted in 837 undergraduates drawn from four comprehensive universities in Jiangxi.RESULTS The first three items involving diet knowledge needs were daily diet error,knowledge about food safety,proper food combining; the first three obtaining approaches needs included seminar,lessons and network about healthful diet; and the top three diet education approaches needs were optional course,special lecture,extracurricular activities.CONCLUSION Healthy diet education needs degree of comprehensive university students is high,so it should be promptly carried out.

  15. The Design of VoIP Terminal Device Based on DM365%基于DM365的IP语音终端设计

    Institute of Scientific and Technical Information of China (English)

    徐海潮; 张江鑫; 蒋伊乐

    2013-01-01

    This paper presents the whole hardware and software framework of the VoIP portable device based on DM365 , focusing on power management , voice codec module and wireless module .It mainly explains the local part of recording .This terminal device has the function of recording , supporting G .711 , storage and playback .It can be used for voice communications via 3 G or Wi-Fi combined with network transmission proto-col.%该文给出了基于DM365的便携式IP语音终端的整体硬件和软件框架,重点阐述了电源管理、语音编解码模块与无线模块等硬件设计,主要讲解了本地录音部分。该终端可以实现语音的录音,G711编解码,存储与回放,可在3G 与 WiFi 间自由切换,结合网络传输协议可用于语音通信。

  16. 基于DM642的嵌入式虹膜识别系统设计%Design of embedded iris identification system based on DM642

    Institute of Scientific and Technical Information of China (English)

    黄健; 沈建新

    2012-01-01

    提出一种基于TMS320DM642的嵌入式虹膜识别系统设计方案.该系统集图像采集、图像处理以及图像识别于一体,采用DSP/BIOS嵌入式操作系统,实现对虹膜图像的实时处理.对归一化的虹膜图像采用2D-Gabor滤波器实现特征提取,通过比较海明距实现编码匹配.实验表明,该系统具有识别准确率高、体积小、功耗低以及可靠性高等优点.%In this paper, a kind of embedded iris identification system based on DM642 is put forward. This system has image acquisition, image processing and image recognition .The software system is developed with DSP/BIOS embedded operating system to realize the real-time processing of iris image. With 2D - Gabor filter, the feature of normalized iris images is extracted, and the code is matched by hamming distance. Experiment results show that this system can run efficiently and stalility, which has high i-dentification accuracy, small size and low power consumption.

  17. The DM-QIM Digital Image Watermarking Algorithm Based on DCT Transformation%基于DCT变换下的DM-QIM数字图像水印算法

    Institute of Scientific and Technical Information of China (English)

    陈燕

    2013-01-01

    基于DCT域下的水印算法相对于空域中水印算法具有更好的稳定性,更大的容量,以及更好的隐蔽性,同时在借助人类的感知模型的情况下能设计出具有较好保真度的水印系统。本论文对DM-QIM(Quantization Index Modulation)水印方案进行了系统的研究,介绍了这种数字水印算法的原理及模型,探究了数字水印的嵌入和提取方案,最后对实验结果做了分析和总结。%DCT-based watermarking algorithm with respect to the airspace watermarking algorithm has strong robustness, and larger capacity, better concealment. While using human perception model can design better fidelity watermarking system. This chapter examines a DM-QIM (Quantization Index Modulation) watermarking scheme, describes the principle of the digital watermarking algorithm and model to analyze the digital watermark embedding and extraction program, finally analyzes and summarizes the experimental results.

  18. Technical improvements in the DNA analysis of the myotonic dystrophy (DM) mutation

    Energy Technology Data Exchange (ETDEWEB)

    Leblond, S.; Lehev, D.; Barcelo, J. [Children`s Hospital of Eastern Ontario, Ottawa (Canada)] [and others

    1994-09-01

    It has become increasingly clear that widespread clinical application of routine DNA diagnosis requires robust and easily replicated methodologies. Mutation analysis in DM involves detection of a CTG expansion which may increase in size between generations within a family. DNA testing has required two distinct methods: genomic and PCR DNA Southern blotting. Genomic Southerns visualize from E1 (hundreds of repeats) to the very largest E4 (thousands of repeats in congenital DM). PCR Southerns permit detection of the smallest mutations (E0, protomutations associated with minimal if any clinical signs) to E3, but E4 is not uniformly visualized. In order to improve the DM testing such that even the largest expansions are visualized by a single PCR test, we have altered the PCR conditions. Since the PCR conditions do not substantially affect the normal allele of less than 200 bp, CTG expansion must be directly monitored by hybridization with a labelled (CTG){sub 10} oligonucleotide. Unlike PCR of the CGG expansion in fragile X, addition of deazaGTP reduced visualization of the DM expansion. Addition of single-stranded protein and DMSO significantly improved PCR up to ten-fold such that E4s were visualized. The CTG expansion was very sensitive to the denaturing cycle temperature (which does not affect the intensity of the normal allele). Thus, 96{degrees}C on the Perkin Elmer 480 was optimal in our hands, with 98{degrees}C and 94{degrees}C actually causing loss of even the intermediate sized E1 and E2 expansions. This has implications when setting up the DM test on different thermocyclers where digital readings may not reflect actual block temperature. These PCR `tune-ups` will support more reliable and streamlined analyses, as more expansion mutations are recognized and routinely offered for clinical use.

  19. Effects of soybean meal or canola meal on milk production and methane emissions in lactating dairy cows fed grass silage-based diets.

    Science.gov (United States)

    Gidlund, H; Hetta, M; Krizsan, S J; Lemosquet, S; Huhtanen, P

    2015-11-01

    This study evaluated the effects of soybean meal (SBM) and heat-moisture-treated canola meal (TCM) on milk production and methane emissions in dairy cows fed grass silage-based diets. Twenty-eight Swedish Red cows were used in a cyclic change-over experiment with 4 periods of 21 d and with treatments in 2 × 4 factorial arrangement (however, the control diet without supplementary protein was not fed in replicate). The diets were fed ad libitum as a total mixed ration containing 600 g/kg of grass silage and 400 g/kg of concentrates on a dry matter (DM) basis. The concentrate without supplementary protein consisted of crimped barley and premix (312 and 88 g/kg of DM), providing 130 g of dietary crude protein (CP)/kg of DM. The other 6 concentrates were formulated to provide 170, 210, or 250 g of CP/kg of DM by replacing crimped barley with incremental amounts of SBM (50, 100, or 150 g/kg of diet DM) or TCM (70, 140, or 210 g/kg of diet DM). Feed intake was not influenced by dietary CP concentration, but tended to be greater in cows fed TCM diets compared with SBM diets. Milk and milk protein yield increased linearly with dietary CP concentration, with greater responses in cows fed TCM diets compared with SBM diets. Apparent N efficiency (milk N/N intake) decreased linearly with increasing dietary CP concentration and was lower for cows fed SBM diets than cows fed TCM diets. Milk urea concentration increased linearly with increased dietary CP concentration, with greater effects in cows fed SBM diets than in cows fed TCM diets. Plasma concentrations of total AA and essential AA increased with increasing dietary CP concentration, but no differences were observed between the 2 protein sources. Plasma concentrations of Lys, Met, and His were similar for both dietary protein sources. Total methane emissions were not influenced by diet, but emissions per kilogram of DM intake decreased quadratically, with the lowest value observed in cows fed intermediate levels of protein

  20. Personalized diet management can optimize compliance to a high-fiber, high-water diet in children with refractory functional constipation.

    Science.gov (United States)

    Karagiozoglou-Lampoudi, Thomais; Daskalou, Efstratia; Agakidis, Charalambos; Savvidou, Afroditi; Apostolou, Aggeliki; Vlahavas, Georges

    2012-05-01

    Diet modification to increase water and fiber consumption is considered an important component in the management of constipation. This prospective randomized study aimed to evaluate the compliance of 86 children with refractory functional constipation (mean age 4.4 years, range 1 to 11 years)-to a high-fiber, high-water diet following either physician's dietary advice (PI group) (n=42) or physician's dietary advice plus personalized diet management by a registered dietitian (DM group) (n=44). Dietary intake was assessed by a 24-hour dietary recall at baseline and 1 month later. The changes in water and fiber consumption were used as compliance criteria. DM group had comparable anthropometric measurements; sex distribution; and baseline intakes of energy, macronutrient, water, and dietary fiber compared with the PI group. Comparison of nutrient intakes between the two visits within each group showed a significant increase in fiber consumption in both groups that was more pronounced in the DM group. Water, energy, and carbohydrate consumption increased significantly only in the DM group. Multivariate regression analysis revealed that the intervention group was the only significant independent predictor for the change in fiber and water consumption after controlling for age, sex, and weight-for-age z score. Children receiving personalized diet management for refractory functional constipation achieved better compliance in increasing fiber and water consumption. Copyright © 2012 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  1. Health Education of Ketogenic Diet Therapy for Children with Intractable Epilepsy%难治性癫癎患儿生酮饮食治疗的全程健康教育

    Institute of Scientific and Technical Information of China (English)

    林梅芳; 陈黎; 廖建湘; 邓丽娥; 叶敬花

    2012-01-01

    从2008年起,由专病护士对癫癎门诊收治的40例生酮饮食疗法患儿实施全程健康教育,利用入院前门诊就诊、住院治疗期间、出院访视及门诊复诊等渠道,进行相关知识健康教育及技能指导,每个病例跟踪6个月并观察疗效.实施全程健康教育后,增强了患儿及家长坚持生酮饮食的信心.跟踪随访半年结果显示,33例能坚持生酮饮食6个月,其中22例达到控制癫癎发作90%以上,10例开始逐步减少抗癫癎药的用量.%This paper introduced the health education of ketogenic diet therapy for 40 children with intractable epilepsy. Related health education and skill guidance were implemented through various approaches. A six-month follow-up was conducted for each child, which indicated that 33 of them could insist on diet therapy for half a year. The diet therapy exerted positive influence on their treatment and recovery.

  2. Effect analysis applications of food model on diet education of obesity disease%应用食物模型进行肥胖患者饮食教育的效果分析

    Institute of Scientific and Technical Information of China (English)

    苏惠崧; 卢桂好; 张秀薇

    2012-01-01

    目的 探索一种较好的肥胖患者饮食教育形式.方法 把符合条件的肥胖患者随机分为研究组和对照组,最后完成研究的人数分别为研究组54例,对照组58例.两组患者都进行肥胖饮食理论教育,对照组使用资料、图片,研究组除使用资料、图片外另加食物模型.结果 两组患者教育前后比较,白蛋白(ALB)、血红蛋白(HGB)等指标变化不大(P>0.05);两组肥胖饮食理论知识得分显著提高(P0.05),TG有下降(P 0.05). The food diet theoretical knowledge score in both groups had significani difference (P 0.05), TG was decremented (P < 0.05). The diet education effect of the observation group was better than that of the control group (P < 0.05). Conclusion Applications of food model on diet education is conductive to improve the status of nu1.rii.iona] of patients with obesity.

  3. Daily methane production pattern of Welsh ponies fed a roughage diet with or without a cereal mixture.

    Science.gov (United States)

    Dansen, O; Pellikaan, W F; Hendriks, W H; Dijkstra, J; Jacobs, M P T; Everts, H; van Doorn, D A

    2015-04-01

    Methane production from Welsh ponies fed 2 isoenergetic diets (NE basis) at maintenance was studied in a crossover design with 4 mature geldings (230 ± 10.5 kg BW, mean ± SE). Treatments included a roughage-only (R) diet (5.1 kg DM/d) or a roughage plus cereal mix (RC) diet (2.5 kg DM hay/d plus 1.1 kg DM cereal mix/d). For both diets, the same grass hay was used (898 g DM/kg and 4.5 MJ NE/kg DM) and a commercial cereal mix was used in the RC diet (890 g DM/kg and 9.6 MJ NE/kg DM). Ponies were housed in pairs in climate-controlled respiration chambers. Carbon dioxide production (CO2), oxygen (O2) consumption, and CH4 production were measured over 3 consecutive days. Heat production (HP) rates were calculated from gaseous exchange. Feces were collected quantitatively to determine dietary nutrient digestibility. Dry matter intake differed between diets (P Methane production was higher (P = 0.014) on the R diet (29.8 L · pony(-1) · d(-1)) compared to the RC diet (23.2 L · pony(-1) · d(-1)). Methane production expressed in liters/kilogram metabolic body weight (BW0.75) per day tended (P = 0.064) to decrease with 21% for the RC group compared with the R group. Heat production, O2 consumption, and CO2 production were not affected by diet. Diurnal patterns of CH4 production and HP were similar for both diets. Methane production increased slightly (P < 0.652) after feeding and was numerically lower for the RC diet for all time points throughout the day. For both diets, HP was higher after feeding than before feeding and decreased again within approximately 3 h after feeding. Isoenergetic replacement of roughage by a cereal mix reduces CH4 production in ponies. No clear diurnal pattern in CH4 emission can be discerned in ponies fed at maintenance.

  4. Psychological aspects of diet therapy in type 2 diabetes mellitus

    OpenAIRE

    E G Starostina

    2008-01-01

    The importance of studying the psychological aspects of nutrition diet is, perhaps, the most commonly used words in the lexicon of Endocrinology and Diabetology and most unpleasant - for patients with diabetes mellitus (DM). Any restrictions on certain aspects of nutrition in patients with diabetes create a negative attitude to the disease, since they require non-established habits and tastes, a significant change in lifestyle, often - constant "struggle" with gusto. And if type 1 diabetes de...

  5. The rationale, design, and baseline characteristics of PREVENT-DM: A community-based comparative effectiveness trial of lifestyle intervention and metformin among Latinas with prediabetes.

    Science.gov (United States)

    Perez, Alberly; Alos, Victor A; Scanlan, Adam; Maia, Catarina M; Davey, Adam; Whitaker, Robert C; Foster, Gary D; Ackermann, Ronald T; O'Brien, Matthew J

    2015-11-01

    Promotora Effectiveness Versus Metformin Trial (PREVENT-DM) is a randomized comparative effectiveness trial of a lifestyle intervention based on the Diabetes Prevention Program delivered by community health workers (or promotoras), metformin, and standard care. Eligibility criteria are Hispanic ethnicity, female sex, age ≥ 20 years, fluent Spanish-speaking status, BMI ≥ 23 kg/m(2), and prediabetes. We enrolled 92 participants and randomized them to one of the following three groups: standard care, DPP-based lifestyle intervention, or metformin. The primary outcome of the trial is the 12-month difference in weight between groups. Secondary outcomes include the following cardiometabolic markers: BMI, waist circumference, blood pressure, and fasting plasma glucose, hemoglobin A1C (HbA1c), total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, and insulin. PREVENT-DM participants are socioeconomically disadvantaged Latinas with a mean annual household income of $15,527 ± 9922 and educational attainment of 9.7 ± 3.6 years. Eighty-six percent of participants are foreign born, 20% have a prior history of gestational diabetes, and 71% have a first-degree relative with diagnosed diabetes. At baseline, PREVENT-DM participants had a mean age of 45.1 ± 12.5 years, weight of 178.8 ± 39.3 lbs, BMI of 33.3 ± 6.5 kg/m(2), HbA1c of 5.9 ± 0.2%, and waist circumference of 97.4 ± 11.1cm. Mean baseline levels of other cardiometabolic markers were normal. The PREVENT-DM study successfully recruited and randomized an understudied population of Latinas with prediabetes. This trial will be the first U.S. study to test the comparative effectiveness of metformin and lifestyle intervention versus standard care among prediabetic adults in a "real-world" setting.

  6. Design of UAV video encoding system based on DM368%基于 DM368的无人机视频压缩系统的设计

    Institute of Scientific and Technical Information of China (English)

    吴笑天; 鲁剑锋; 王宇庆; 陈典兵

    2014-01-01

    无人机视频数据的实时压缩处理是无人机的关键技术之一.本文以 DM368为核心处理器,以嵌入式 Linux 为板级操作系统,设计出一套可供无人机使用的低功耗视频实时压缩系统.与传统的嵌入式视频 H264软件编码压缩系统相比,本系统依赖 DM368内嵌的视频协处理硬核处理 H264编码,具有功耗低,处理延迟小,外部电路简单等诸多优势.同时系统以嵌入式 Linux 为板级操作系统,实时性强,可稳定高效的管理视频采集、硬核调度、串口通讯、数据输出等诸多任务.试验结果表明,本系统在处理 PAL 制式为视频源的 H264编码任务时,平均功耗仅为1.5 W,具有功耗低、成本低、体积小、重量轻、实时性强等诸多优势,能够满足无人机视频压缩的应用需求.%Real-time UAV video data compression is one of the key technology of UAV.In this paper we propose a real-time,low-power video encoding system design,based on DM368 processor and em-bedded Linux operating system.Compared with traditional embedded video H264 encoding system de-sign,we use DM368 inner video image co-processors to process the encoding task,which has the ad-vantage of low-power consumption,low processing delay,and simple external circuit design.Further-more,we utilize the real-time,stable and efficient embedded Linux operating system,capable of pro-cessing multi-task,such as video capturing,hard-core scheduling,serial communication,and data transmission.Experiment shows that the average power consumption of our system is only 1.5 W when dealing with the PAL video H264 coding task.Our design meet the requirement of UAV video compression task efficiently,with the advantage of low-power,low-cost,small-size,light-weight, and good real-time quality.

  7. YB-DM-3有机玻璃的疲劳性能研究%Study Fatigue Property of YB-DM-3 Perspex

    Institute of Scientific and Technical Information of China (English)

    马丽婷; 陈新文; 厉蕾

    2011-01-01

    YB-DM-3有机玻璃因其具有良好的透光性和力学性能,目前在飞机上已经得到广泛应用,它是一种区别于金属材料的高分子材料,通过对有机玻璃拉伸疲劳性能的测试得到了疲劳S-N曲线和条件疲劳极限;比较了不同应力比下的有机玻璃拉伸疲劳S-N曲线,随着应力比的增加曲线整体上移.%Perspex have light permeability and mechanical performance, and its application on aircraft is high molecular material of metallic material, test property fatigue of tensile, the perspex S-N curve of tensile fatigue was present in this research.

  8. Implemetation of health education about standard diabetic diets in patients with diabetes melitus%糖尿病患者标准化饮食健康教育的实施

    Institute of Scientific and Technical Information of China (English)

    陶静; 胡鹏; 徐蓉; 曾铁英

    2013-01-01

    目的 探讨标准化饮食健康教育对糖尿病患者饮食知识、行为、血糖控制效果的影响.方法 将100例诊断为糖尿病且无糖尿病并发症的患者按照住院时间顺序分成对照组与观察组各50例.对照组由管床护士按照自行设计的健康教育路径进行饮食教育,观察组采用标准化饮食健康教育对糖尿病患者进行饮食教育.观察3个月后糖尿病患者饮食知识掌握的程度,患者饮食行为改变的情况以及血糖的变化.结果 干预后3个月,观察组饮食知识、行为评分显著高于对照组,空腹血糖、餐后2 h血糖显著低于对照组(均P<0.01).结论 标准化饮食健康教育对患者饮食教育有针对性地进行指导,并将饮食知识转化为技能,落实在日常行动中,在促使患者行为改变及血糖控制方面优于传统健康教育方式.%Objective To explore the effect of health education about standard diabetic diets on diabetic patients knowledge of diets, their behaviors in diet preparation, and glucose control. Methods A total of 100 patients diagnosed with diabetes mellitus and in the abscence of complications were equally divided into an observation group and a control group according to the sequence of hospitali-zation. The control group were subjected to a self-designed health education path directed by their charge nurses, while the observation group received health education about standard diabetic diets. Three months later, the diabetes patients knowledge level of diets, their food-related behaviors, and glucose levels were compared. Results At three months of the intervention, the observation group patients scores of diet knowledge, and food-related behaviors were significantly higher than the control group;the observation group had lower level of plasma glucose, 2-hour plasma glucose than the control group (P<0.01 for all). Conclusion Health education about standard diabetic diets can directe health-related knowledge to

  9. Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate.

    Science.gov (United States)

    Ortega, Ángeles; Berná, Genoveva; Rojas, Anabel; Martín, Franz; Soria, Bernat

    2017-06-02

    Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex disease resulting from the interaction of genetic, epigenetic, environmental, and lifestyle factors. Nutrients and dietary patterns are important environmental factors to consider in the prevention, development and treatment of this disease. Nutritional genomics focuses on the interaction between bioactive food components and the genome and includes studies of nutrigenetics, nutrigenomics and epigenetic modifications caused by nutrients. There is evidence supporting the existence of nutrient-gene and T2DM interactions coming from animal studies and family-based intervention studies. Moreover, many case-control, cohort, cross-sectional cohort studies and clinical trials have identified relationships between individual genetic load, diet and T2DM. Some of these studies were on a large scale. In addition, studies with animal models and human observational studies, in different countries over periods of time, support a causative relationship between adverse nutritional conditions during in utero development, persistent epigenetic changes and T2DM. This review provides comprehensive information on the current state of nutrient-gene interactions and their role in T2DM pathogenesis, the relationship between individual genetic load and diet, and the importance of epigenetic factors in influencing gene expression and defining the individual risk of T2DM.

  10. 基于DM3730平台的智能数字视频监控系统%Intelligent Digital Video Surveillance System Based on DM3730

    Institute of Scientific and Technical Information of China (English)

    周建平; 刘歆浏

    2012-01-01

    Aiming at disadvantages of traditional PC platform monitoring system, such as high system cost, low calculating ability, simple functions, large size, complex operation, and limited usages range, design and implement an intelligent digital control system taking TI company is DM3730 as core. System uses a modular design, a Linux operating system, expansion of a variety of display outputs, configured with CMOS image sensors, Gigabit Ethernet interface module for automatic analysis of video streaming, motion detection, identification, tracking and early warning threat targets, and use Ethernet video compression and transmission. It has the advantages of low cost, high reliability, low false alarm rate.%针对传统PC平台的监控系统成本高、运算能力低、功能单一、体积大、操作复杂、使用范围受限的问题,设计及实现了一款以TI公司的DM3730为核心的智能数字监控系统.该监控系统采用模块化设计,以Linux为操作系统,扩展有多种显示输出接口,配置标准CMOS图像传感器,千兆以太网口等模块.该系统能自动分析视频流,主动检测、识别、跟踪及预警威胁目标,并用以太网实现视频的压缩传输,具备低成本、可靠性高、虚警率低的特点.

  11. Feeding behavior of dairy cows in feedlot and fed on crude glycerin levels in the diet

    OpenAIRE

    Murilo de Almeida Meneses; Fabiano Ferreira da Silva; Alex Resende Schio; Robério Rodrigues Silva; Dicastro Dias de Souza; Antônio Ferraz Porto Junior

    2014-01-01

    Current experiment evaluated the inclusion effect of crude glycerin levels in the diet on the feeding behavior of confined dairy cows. Fifteen crossbred Holsteinx Zebu cows were used, divided into three 5 x 5 Latin squares, with treatments: control (no addition of glycerin) and inclusion of 50, 100, 150 and 200 gcrude glycerin per kg of dry matter (DM) in the diet. The animals were subjected to five visual assessments of feeding behavior for 24 hours in each period. Linear increase on feeding...

  12. The New Nordic Diet

    DEFF Research Database (Denmark)

    Salomo, Louise; Poulsen, Sanne Kellebjerg; Rix, Marianne

    2016-01-01

    PURPOSE: High phosphorus content in the diet may have adverse effect on cardiovascular health. We investigated whether the New Nordic Diet (NND), based mainly on local, organic and less processed food and large amounts of fruit, vegetables, wholegrain and fish, versus an Average Danish Diet (ADD...... modifications of the diet are needed in order to make this food concept beneficial regarding phosphorus absorption....

  13. Resistance to Downy Mildew in Lettuce 'La Brillante' is Conferred by Dm50 Gene and Multiple QTL.

    Science.gov (United States)

    Simko, Ivan; Ochoa, Oswaldo E; Pel, Mathieu A; Tsuchida, Cayla; Font I Forcada, Carolina; Hayes, Ryan J; Truco, Maria-Jose; Antonise, Rudie; Galeano, Carlos H; Michelmore, Richard W

    2015-09-01

    Many cultivars of lettuce (Lactuca sativa L.) are susceptible to downy mildew, a nearly globally ubiquitous disease caused by Bremia lactucae. We previously determined that Batavia type cultivar 'La Brillante' has a high level of field resistance to the disease in California. Testing of a mapping population developed from a cross between 'Salinas 88' and La Brillante in multiple field and laboratory experiments revealed that at least five loci conferred resistance in La Brillante. The presence of a new dominant resistance gene (designated Dm50) that confers complete resistance to specific isolates was detected in laboratory tests of seedlings inoculated with multiple diverse isolates. Dm50 is located in the major resistance cluster on linkage group 2 that contains at least eight major, dominant Dm genes conferring resistance to downy mildew. However, this Dm gene is ineffective against the isolates of B. lactucae prevalent in the field in California and the Netherlands. A quantitative trait locus (QTL) located at the Dm50 chromosomal region (qDM2.2) was detected, though, when the amount of disease was evaluated a month before plants reached harvest maturity. Four additional QTL for resistance to B. lactucae were identified on linkage groups 4 (qDM4.1 and qDM4.2), 7 (qDM7.1), and 9 (qDM9.2). The largest effect was associated with qDM7.1 (up to 32.9% of the total phenotypic variance) that determined resistance in multiple field experiments. Markers identified in the present study will facilitate introduction of these resistance loci into commercial cultivars of lettuce.

  14. Dynamics of the diffusive DM-DE interaction--dynamical system approach

    CERN Document Server

    Haba, Zbigniew; Szydlowski, Marek

    2016-01-01

    We discuss dynamics of a model of an energy transfer between dark energy (DE) and dark matter (DM). The energy transfer is determined by a non-conservation law resulting from a diffusion of dark matter in an environment of dark energy. The relativistic invariance defines the diffusion in a unique way. The system can contain baryonic matter and radiation which do not interact with the dark sector. We treat the Friedman equation and the conservation laws as a closed dynamical system. The dynamics of the model is examined using the dynamical systems methods for demonstration how solutions depend on initial conditions. We also fit the model parameters using astronomical observation: SNIa, $H(z)$, BAO and Alcock-Paczynski test. We show that the model with diffuse DM-DE is consistent with the data.

  15. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM

    Directory of Open Access Journals (Sweden)

    Yang Liu

    2016-01-01

    Full Text Available Background. Epicardial adipose tissue (EAT is identified as an atypical fat depot surrounding the heart with a putative role in the involvement of metabolic disorders, including obesity, type-2 diabetes mellitus, and atherosclerosis. We profiled miRNAs in EAT of metabolic patients with coronary artery disease (CAD and type-2 diabetes mellitus (T2DM versus metabolically healthy patients by microarray. Compared to metabolically healthy patients, we identified forty-two miRNAs that are differentially expressed in patients with CAD and T2DM from Xinjiang, China. Eleven miRNAs were selected as potential novel miRNAs according to P value and fold change. Then the potential novel miRNAs targeted genes were predicted via TargetScan, PicTar, and miRTarbase, and the function of the target genes was predicted via Gene Ontology (GO analysis while the enriched KEGG pathway analyses of the miRNAs targeted genes were performed by bioinformatics software DAVID. Then protein-protein interaction networks of the targeted gene were conducted by online software STRING. Finally, using microarray, bioinformatics approaches revealed the possible molecular mechanisms pathogenesis of CAD and T2DM. A total of 11 differentially expressed miRNAs were identified and among them, hsa-miR-4687-3p drew specific attention. Bioinformatics analysis revealed that insulin signaling pathway is the central way involved in the progression of metabolic disorders. Conclusions. The current findings support the fact that miRNAs are involved in the pathogenesis of metabolic disorders in EAT of CAD patients with T2DM, and validation of the results of these miRNAs by independent and prospective study is certainly warranted.

  16. Protoplanetary disk formation and evolution models: DM Tau and GM Aur

    Science.gov (United States)

    Hueso, R.; Guillot, T.

    2002-09-01

    We study the formation and evolution of protoplanetary disks using an axisymmetric turbulent disk model. We compare model results with observational parameters derived for the DM Tau and GM Aur systems. These are relatively old T Tauri stars with large and massive protoplanetary disks. Early disk formation is studied in the standard scenario of slowly rotating isothermal collapsing spheres and is strongly dependent on the initial angular momentum and the collapse accretion rate. The viscous evolution of the disk is integrated in time using the classical Alpha prescription of turbulence. We follow the temporal evolution of the disks until their characteristics fit the observed characteristics of DM Tau and GM Aur. We therefore obtain the set of model parameters that are able to explain the present state of these disks. We also study the disk evolution under the Beta parameterization of turbulence, recently proposed for sheared flows on protoplanetary disks. Both parameterizations allow explaining the present state of both DM Tau and GM Aur. We infer a value of Alpha between 5x10-3 to 0.02 for DM Tau and one order of magnitude smaller for GM Aur. Values of the Beta parameter are in accordance with theoretical predictions of Beta around 2x10-5 but with a larger dispersion on other model parameters, which make us favor the Alpha parameterization of turbulence. Implications for planetary system development in these systems are presented. In particular, GM Aur is a massive and slowly evolving disk where conditions are very favorable for planetesimal growth. The large value of present disk mass and the relatively small observed accretion rate of this system may also be indicative of the presence of an inner gas giant planet. Acknowledgements: This work has been supported by Programme Nationale de Planetologie. R. Hueso acknowledges a post-doctoral fellowship from Gobierno Vasco.

  17. DD-08PHASE I CANCER CLINICAL TRIAL FOR 4-DEMETHYL-4-CHOLESTERYLOXYCARBONYLPENCLOMEDINE (DM-CHOC-PEN)

    Science.gov (United States)

    Ware, Marcus; Weiner, Roy; Friedlander, Paul; Gordon, Crag; Saenger, Yvonne; Mahmood, Tallat; Rodgers, Andrew; Bastian, Gerald; Urien, S.; Lee; Morgan, Roy

    2014-01-01

    PURPOSE: DM-CHOC-PEN is a poly-chlorinated pyridine cholesteryl carbonate whose MOA is via alkylation of DNA @ N7 – guanine and via oxidative stress. The aims of this clinical trial were to determine maximum-tolerated dose (MTD), safety, dose-limiting toxicities (DLTs), pharmacokinetics (PK) of DM-CHOC-PEN and monitor for clinical responses. METHODS: DM-CHOC-PEN was administered as a 3-hr IV infusion once every 21-days to patients with advanced cancer; melanoma (n = 3), colorectal CA (n = 3), breast (n = 3) and glioblastoma multiforme (n = 6). The trial included patients with advanced cancer +/- CNS involvement. The starting dose was 39 mg/m2 with escalations to date up to 111 mg/m2. RESULTS: Twenty-six (26) patients have been treated. The MTD was 2-tiered and defined as 85.8 mg/m2 for patients with liver involvement and 98.7 mg/m2 for patients without liver abnormalities. The most common adverse effects were fatigue (n = 2), liver dysfunction – elevated bilirubin (Gr-3, n = 3; Gr-2, n = 1), ALT/AST (Gr-2, n = 3), alk phos (Gr-2, n = 3) and an allergic reaction (Gr-2, n = 1). Three (3) patients with liver metastasis demonstrated hyperbilirubinemia (Gr-3 SLT) – 2 at the 98.7 mg/m2 and one (1) at the 111 mg/m2 levels Five (5) additional patients with liver disease have been treated at 85.8 mg/m2 level without toxicity. CONCLUSIONS: DM-CHOC-PEN is safe at the presented dose levels and has a favorable PK profile. Eight (8) patients had responses or significant PFS, including 6 with CNS involvement. A Phase II trial has begun in patients with primary brain cancer and brain metastases from melanoma, breast cancer and lung cancer.

  18. Sensitive limits on the abundance of cold water vapor in the DM Tauri protoplanetary disk

    NARCIS (Netherlands)

    Bergin, E.A.; Hogerheijde, M.R.; Brinch, C.; Fogel, J.; Yıldız, U.A.; Kristensen, L.E.; van Dishoeck, E.F.; Bell, T.A.; Blake, G.A.; Cernicharo, J.; Dominik, C.; Lis, D.; Melnick, G.; Neufeld, D.; Panić, O.; Pearson, J.C.; Bachiller, R.; Baudry, A.; Benedettini, M.; Benz, A.O.; Bjerkeli, P.; Bontemps, S.; Braine, J.; Bruderer, S.; Caselli, P.; Codella, C.; Daniel, F.; Di Giorgio, A.M.; Doty, S.D.; Encrenaz, P.; Fich, M.; Fuente, A.; Giannini, T.; Goicoechea, J.R.; de Graauw, T.; Helmich, F.; Herczeg, G.J.; Herpin, F.; Jacq, T.; Johnstone, D.; Jørgensen, J.K.; Larsson, B.; Liseau, R.; Marseille, M.; McCoey, C.; Nisini, B.; Olberg, M.; Parise, B.; Plume, R.; Risacher, C.; Santiago-García, J.; Saraceno, P.; Shipman, R.; Tafalla, M.; van Kempen, T.A.; Visser, R.; Wampfler, S.F.; Wyrowski, F.; van der Tak, F.; Jellema, W.; Tielens, A.G.G.M.; Hartogh, P.; Stützki, J.; Szczerba, R.

    2010-01-01

    We performed a sensitive search for the ground-state emission lines of ortho-and para-water vapor in the DM Tau protoplanetary disk using the Herschel/HIFI instrument. No strong lines are detected down to 3 sigma levels in 0.5 km s(-1) channels of 4.2 mK for the 1(10)-1(01) line and 12.6 mK for the

  19. TREX-DM: a low background Micromegas-based TPC for low-mass WIMP detection

    CERN Document Server

    Iguaz, F J; Aznar, F; Castel, J F; Cebrian, S; Dafni, T; Garcia, J A; Irastorza, I G; Lagraba, A; Luzon, G; Peiro, A

    2016-01-01

    Dark Matter experiments are recently focusing their detection techniques in low-mass WIMPs, which requires the use of light elements and low energy threshold. In this context, we describe the TREX-DM experiment, a low background Micromegas-based TPC for low-mass WIMP detection. Its main goal is the operation of an active detection mass $\\sim$0.3 kg, with an energy threshold below 0.4 keVee and fully built with previously selected radiopure materials. This work describes the commissioning of the actual setup situated in a laboratory on surface and the updates needed for a possible physics run at the Canfranc Underground Laboratory (LSC) in 2016. A preliminary background model of TREX-DM is also presented, based on a Geant4 simulation, the simulation of the detector's response and two discrimination methods: a conservative muon/electron and one based on a neutron source. Based on this background model, TREX-DM could be competitive in the search for low-mass WIMPs. In particular it could be sensitive, e.g., to t...

  20. Anti-listerial Bactericidal Activity of Lactobacillus plantarum DM5 Isolated from Fermented Beverage Marcha.

    Science.gov (United States)

    Das, Deeplina; Goyal, Arun

    2013-09-01

    The strain Lactobacillus plantarum DM5 was isolated from fermented beverage Marcha of Sikkim and explored for its antagonistic activity against food-borne pathogens. The cell-free supernatant of L. plantarum DM5 showed antibacterial activity of 6,400 AU/mL in MRS medium (pH 6.0) against the indicator strain Staphylococcus aureus. MRS medium supplemented with 15 g/L of maltose at 37 °C under static condition yielded highest antimicrobial activity (6,400 AU/mL) with 3 % increase in specific activity when compared to 20 g/L glucose. The antimicrobial compound was heat stable (60 min at 100 °C) and was active over a wide pH range. It showed bactericidal effect on S. aureus and Listeria monocytogenes by causing 96 and 98 % of cell lysis, respectively. The cell morphology of the treated S. aureus and L. monocytogenes was completely deformed as revealed by scanning electron microscopy, suggesting the high potential of L. plantarum DM5 as natural preservatives in food industry. The antimicrobial compound was purified by 80 % ammonium sulphate precipitation and showed antimicrobial activity of 12,800 AU/mL with 19-fold purification and a molecular mass of 15.2 kDa, indicating the proteinaceous nature of the compound.

  1. Effect of Exercise on Psychological Well-being in T2DM

    Directory of Open Access Journals (Sweden)

    Farzad Najafipoor

    2011-09-01

    Full Text Available Background: Type 2 diabetic patients (T2DM experience health problems including psychiatric and psychological complications that influence their general health. Since exercise has an additional effect on psychological improvement, we aimed to establish the role of exercise as improvement of psychological problems. Methods: 80 subjects with T2DM were assigned to take exercise for 90 minutes per session, 3 times a week for a period of 4 months. They answered the GHQ-12 questionnaire before and after the study project. Results: Questionnaires were scored by Likert model and entered the statistical analysis. Our findings demonstrate a significant decrease in the mean GHQ-12 scores. [13.39 ± 5.89 to 8.52 ± 5.12 (p < 0.001]. Factor analysis by Graetz's three-factor model suggests that factor I (anxiety and depression associates with more improvement than the other factors.Conclusion: Exercise improves psychological distress in T2DM and results in improved well-being.

  2. Fault-tolerant drive electronics for a Xinetics deformable mirror at GeMS DM0

    Science.gov (United States)

    Barberio, Michael J.

    2016-07-01

    Gemini South is replacing one of the (3) CILAS DMs with a 349-actuator Xinetics DM in its GeMS MCAO system. Xinetics mirrors operate over a 40-100V dynamic range and require that inter-actuator stroke differences are limited to half-scale; each actuator must be within 30V of its neighbor to prevent mechanical stress and possible face sheet separation. A robust way to implement this protection is to use high power transient voltage suppressors (TVSs) as a 2D-mesh between the amplifiers and mirror, but this has system implications. A sustained clamp condition dissipates significant power in the devices, and if an actuator fails as short (which occurred once with the DM in a thermal chamber), the system is subject to a cascade failure event as multiple outputs drive the shorted actuator through the TVS network. This latter risk is readily resolved by using series fuses to the DM. In this third-generation driver, current sensing and logic inhibit amplifier outputs after a sustained TVS clamp condition or shorted output, and LED indicators show the location. Redundant thermal sensing is used on modular TVS row and column boards. A second 2D-mesh of high impedance resistors after the fuses will hold an unpowered channel to the average voltage of its neighbors, with a negligible influence function. A Failure Modes and Effects Analysis shows significant fault tolerance.

  3. Assessing Cognitive Processes with Diffusion Model Analyses: A Tutorial based on fast-dm-30

    Directory of Open Access Journals (Sweden)

    Andreas eVoss

    2015-03-01

    Full Text Available Diffusion models can be used to infer cognitive processes involved in fast binary decision tasks. The model assumes that information is accumulated continuously until one of two thresholds is hit. In the analysis, response time distributions from numerous trials of the decision task are used to estimate a set of parameters mapping distinct cognitive processes. In recent years, diffusion model analyses have become more and more popular in different fields of psychology. This increased popularity is based on the recent development of several software solutions for the parameter estimation. Although these programs make the application of the model relatively easy, there is a shortage of knowledge about different steps of a state-of-the-art diffusion model study. In this paper, we give a concise tutorial on diffusion modelling, and we present fast-dm-30, a thoroughly revised and extended version of the fast-dm software (Voss & Voss, 2007 for diffusion model data analysis. The most important improvement of the fast-dm version is the possibility to choose between different optimization criteria (i.e., Maximum Likelihood, Chi-Square, and Kolmogorov-Smirnov, which differ in applicability for different data sets.

  4. Insulin initiation and intensification in patients with T2DM for the primary care physician

    Directory of Open Access Journals (Sweden)

    Unger J

    2011-06-01

    Full Text Available Jeff UngerCatalina Research Institute, Chino, CA, USAAbstract: Type 2 diabetes mellitus (T2DM is characterized by both insulin resistance and inadequate insulin secretion. All patients with the disease require treatment to achieve and maintain the target glycosylated hemoglobin (A1C level of 6.5%–7%. Pharmacological management of T2DM typically begins with the introduction of oral medications, and the majority of patients require exogenous insulin therapy at some point in time. Primary care physicians play an essential role in the management of T2DM since they often initiate insulin therapy and intensify regimens over time as needed. Although insulin therapy is prescribed on an individualized basis, treatment usually begins with basal insulin added to a background therapy of oral agents. Prandial insulin injections may be added if glycemic targets are not achieved. Treatments may be intensified over time using patient-friendly titration algorithms. The goal of insulin intensification within the primary care setting is to minimize patients' exposure to chronic hyperglycemia and weight gain, and reduce patients' risk of hypoglycemia, while achieving individualized fasting, postprandial, and A1C targets. Simplified treatment protocols and insulin delivery devices allow physicians to become efficient prescribers of insulin intensification within the primary care arena.Keywords: diabetes, basal, bolus, regimens, insulin analogs, structured glucose testing

  5. Apparent digestibility of mixed feed with increasing levels of chia (Salvia hispanica L. seeds in rabbit diets

    Directory of Open Access Journals (Sweden)

    G. Meineri

    2010-04-01

    Full Text Available Thirty crossbred rabbits were randomly allocated to three groups with ten animals each (five male and five female rabbits each, and kept individually in separate cages. Three isocaloric and isonitrogenous diets were formulated with increasing levels of chia (Salvia hispanica L. seeds (SHS (0, 10, and 15%. The digestibility coefficients of the dry matter (DM, organic matter (OM, crude protein (CP, crude fibre (CF, neutral detergent fibre (NDF, acid detergent fibre (ADF and gross energy (GE were calculated according to standard procedures following the indirect digestibility method, using acid insoluble ash as an internal marker. The results showed that the DM, OM and GE digestibilities of 10% and 15% SHS diets were higher than those of the control diet, while the ADF digestibility of the 15% SHS diet was lower than that of the 10% SHS diet.

  6. Curcumin analog DM-1 in monotherapy or combinatory treatment with dacarbazine as a strategy to inhibit in vivo melanoma progression.

    Directory of Open Access Journals (Sweden)

    Fernanda Faião-Flores

    Full Text Available Malignant melanoma is a highly aggressive form of skin cancer with a high mortality rate if not discovered in early stages. Although a limited number of treatment options for melanoma currently exist, patients with a more aggressive form of this cancer frequently decline treatment. DM-1 is a sodium phenolate and curcumin analog with proven anticancer, anti-proliferative and anti-metastatic properties. In this paper, the DM-1 compound showed in vivo antitumor activity alone or in combination with chemotherapeutic DTIC in B16F10 melanoma-bearing mice. Beneficial effects such as melanoma tumor burden reduction with pyknotic nuclei, decreased nuclei/cytoplasmic ratio and nuclear degradation occurred after DM-1 treatment. No toxicological changes were observed in the liver, kidneys, spleen and lungs after DM-1 monotherapy or DTIC combined therapy. DTIC+DM-1 treatment induced the recovery of anemia arising from melanoma and immunomodulation. Both DM-1 treatment alone and in combination with DTIC induced apoptosis with the cleavage of caspase-3, -8 and -9. Furthermore, melanoma tumors treated with DM-1 showed a preferential apoptotic intrinsic pathway by decreasing Bcl-2/Bax ratio. Considering the chemoresistance exhibited by melanoma towards conventional chemotherapy drugs, DM-1 compound in monotherapy or in combination therapy provides a promising improvement in melanoma treatment with a reduction of side effects.

  7. Curcumin Analog DM-1 in Monotherapy or Combinatory Treatment with Dacarbazine as a Strategy to Inhibit In Vivo Melanoma Progression

    Science.gov (United States)

    Faião-Flores, Fernanda; Quincoces Suarez, José Agustín; Fruet, Andréa Costa; Maria-Engler, Silvya Stuchi; Pardi, Paulo Celso; Maria, Durvanei Augusto

    2015-01-01

    Malignant melanoma is a highly aggressive form of skin cancer with a high mortality rate if not discovered in early stages. Although a limited number of treatment options for melanoma currently exist, patients with a more aggressive form of this cancer frequently decline treatment. DM-1 is a sodium phenolate and curcumin analog with proven anticancer, anti-proliferative and anti-metastatic properties. In this paper, the DM-1 compound showed in vivo antitumor activity alone or in combination with chemotherapeutic DTIC in B16F10 melanoma-bearing mice. Beneficial effects such as melanoma tumor burden reduction with pyknotic nuclei, decreased nuclei/cytoplasmic ratio and nuclear degradation occurred after DM-1 treatment. No toxicological changes were observed in the liver, kidneys, spleen and lungs after DM-1 monotherapy or DTIC combined therapy. DTIC+DM-1 treatment induced the recovery of anemia arising from melanoma and immunomodulation. Both DM-1 treatment alone and in combination with DTIC induced apoptosis with the cleavage of caspase-3, -8 and -9. Furthermore, melanoma tumors treated with DM-1 showed a preferential apoptotic intrinsic pathway by decreasing Bcl-2/Bax ratio. Considering the chemoresistance exhibited by melanoma towards conventional chemotherapy drugs, DM-1 compound in monotherapy or in combination therapy provides a promising improvement in melanoma treatment with a reduction of side effects. PMID:25742310

  8. Structural characterization of the maytansinoid–monoclonal antibody immunoconjugate, huN901–DM1, by mass spectrometry

    National Research Council Canada - National Science Library

    Wang, Lintao; Amphlett, Godfrey; Blättler, Walter A; Lambert, John M; Zhang, Wei

    2005-01-01

    ...‐specific drug delivery. The immunoconjugate, huN901–DM1, composed of the humanized monoclonal IgG 1 antibody, huN901, and the maytansinoid drug, DM1, is being tested in clinical trials to treat small cell lung carcinoma (SCLC). huN901...

  9. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Goday, A; Bellido, D; Sajoux, I; Crujeiras, A B; Burguera, B; García-Luna, P P; Oleaga, A; Moreno, B; Casanueva, F F

    2016-09-19

    Brackground:The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients. Evaluating the short-term safety and tolerability of a VLCK diet (Diaprokal Method) in subjects with T2DM. Eighty-nine men and women, aged between 30 and 65 years, with T2DM and body mass index between 30 and 35 kg m(-)(2) participated in this prospective, open-label, multi-centric randomized clinical trial with a duration of 4 months. Forty-five subjects were randomly assigned to the interventional weight loss (VLCK diet), and 44 to the standard low-calorie diet. No significant differences in the laboratory safety parameters were found between the two study groups. Changes in the urine albumin-to-creatinine ratio in VLCK diet were not significant and were comparable to control group. Creatinine and blood urea nitrogen did not change significantly relative to baseline nor between groups. Weight loss and reduction in waist circumference in the VLCK diet group were significantly larger than in control subjects (both P<0.001). The decline in HbA1c and glycemic control was larger in the VLCK diet group (P<0.05). No serious adverse events were reported and mild AE in the VLCK diet group declined at last follow-up. The interventional weight loss program based on a VLCK diet is most effective in reducing body weight and improvement of glycemic control than a standard hypocaloric diet with safety and good tolerance for T2DM patients.

  10. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus

    Science.gov (United States)

    Goday, A; Bellido, D; Sajoux, I; Crujeiras, A B; Burguera, B; García-Luna, P P; Oleaga, A; Moreno, B; Casanueva, F F

    2016-01-01

    Brackground: The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients. Objective: Evaluating the short-term safety and tolerability of a VLCK diet (<50 g of carbohydrate daily) in an interventional weight loss program including lifestyle and behavioral modification support (Diaprokal Method) in subjects with T2DM. Methods: Eighty-nine men and women, aged between 30 and 65 years, with T2DM and body mass index between 30 and 35 kg m−2 participated in this prospective, open-label, multi-centric randomized clinical trial with a duration of 4 months. Forty-five subjects were randomly assigned to the interventional weight loss (VLCK diet), and 44 to the standard low-calorie diet. Results: No significant differences in the laboratory safety parameters were found between the two study groups. Changes in the urine albumin-to-creatinine ratio in VLCK diet were not significant and were comparable to control group. Creatinine and blood urea nitrogen did not change significantly relative to baseline nor between groups. Weight loss and reduction in waist circumference in the VLCK diet group were significantly larger than in control subjects (both P<0.001). The decline in HbA1c and glycemic control was larger in the VLCK diet group (P<0.05). No serious adverse events were reported and mild AE in the VLCK diet group declined at last follow-up. Conclusions: The interventional weight loss program based on a VLCK diet is most effective in reducing body weight and improvement of glycemic control than a standard hypocaloric diet with safety and good tolerance for T2DM patients. PMID:27643725

  11. Insulin resistance in obese patients with type 2 diabetes mellitus: effects of a very low calorie diet

    OpenAIRE

    Jazet, Ingrid Maria

    2006-01-01

    Insulin resistance is of major pathogenic importance in obese DM2 and this can be improved by weight loss. Very low calorie diets (VLCDs) are often used for this purpose. This thesis focused on the safety and tolerability of a VLCD and on the short-term and long-term effects of a VLCD on glucose and lipid metabolism in obese DM2 on insulin therapy. Firstly, VLCDs are safe in obese DM2, even for up to 8 months. Secondly, all blood-glucose lowering therapy could be withdrawn simultaneously prov...

  12. [Sustainable diet: history lessons].

    Science.gov (United States)

    Fatati, Giuseppe

    2015-11-01

    Global dietary patterns changed dramatically in the past 50 years, presenting both a boom and a threat to the health and well-being of populations everywhere. We need sustainable diets, with low-input, local and seasonal agro-ecological food productions as well as short distance production-consumption nets for fair trade. The development of a global food system able to guarantee everyone a balanced food intake requires health professionals an awareness and a commitment to increasingly complex education. Dietary changes such as the adherence of to the Mediterranean Dietary Pattern can reduce the environmental footprint and thus the use of natural resources. Increased focus on improving the utilization of freshwater fishes and the correct use of the waters of rivers and lakes should also be encouraged. Cultural heritage, food quality and culinary skills are other key aspects determining sustainable dietary patterns and food security. The Mediterranean street food (Mediterraneità), for intrinsic characteristics, can represent valid model to address the main issues concerning the sustainable food system. The issues of sustainability offer a great opportunity to nutritional science and scientists to play a more central role in the political analysis of future food systems. We are confident that preserve the past helps us understand the present and build for the future, the Mediterranean lifestyle is much more than the Mediterranean diet and, finally, the rivers and the lakes may be our future.

  13. Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.

    Directory of Open Access Journals (Sweden)

    Warunee Dansithong

    Full Text Available The genetic basis of myotonic dystrophy type I (DM1 is the expansion of a CTG tract located in the 3' untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the development of cardiac disease in DM1. Expanded CUG tracts form both nuclear and cytoplasmic aggregates, yet the relative significance of such aggregates in eliciting DM1 pathology is unclear. To test the pathophysiology of CUG repeat encoding RNAs, we developed and analyzed mice with cardiac-specific expression of a beta-galactosidase cassette in which a (CTG(400 repeat tract was positioned 3' of the termination codon and 5' of the bovine growth hormone polyadenylation signal. In these animals CUG aggregates form exclusively in the cytoplasm of cardiac cells. A key pathological consequence of expanded CUG repeat RNA expression in DM1 is aberrant RNA splicing. Abnormal splicing results from the functional inactivation of MBNL1, which is hypothesized to occur due to MBNL1 sequestration in CUG foci or from elevated levels of CUG-BP1. We therefore tested the ability of cytoplasmic CUG foci to elicit these changes. Aggregation of CUG RNAs within the cytoplasm results both in Mbnl1 sequestration and in approximately a two fold increase in both nuclear and cytoplasmic Cug-bp1 levels. Significantly, despite these changes RNA splice defects were not observed and functional analysis revealed only subtle cardiac dysfunction, characterized by conduction defects that primarily manifest under anesthesia. Using a human myoblast culture system we show that this transgene, when expressed at similar levels to a second transgene, which encodes expanded CTG tracts and facilitates both nuclear focus formation and aberrant splicing, does not elicit aberrant splicing. Thus the lack of toxicity of cytoplasmic CUG foci does not appear to be a consequence of low expression levels. Our results therefore demonstrate that the cellular location of CUG RNA

  14. 糖尿病看图对话工具在饮食和运动健康教育中的应用%Application of diabetic conversation map in diet and exercises education for diabetic patients

    Institute of Scientific and Technical Information of China (English)

    胡鹏; 李敏; 徐蓉; 丁迎春

    2011-01-01

    目的 探讨糖尿病看图对话工具在糖尿病饮食和运动知识健康教育中的应用效果.方法 将214例住院治疗的糖尿病患者随机分成传统组和观察组各107例,传统组进行说教式健康教育,观察组在此基础上运用"健康饮食和运动"的看图对话工具进行健康教育.结果 观察组出院前及出院3个月饮食、运动知识笔试成绩显著高于传统组,出院3个月后糖化血红蛋白值显著低于传统组(均P<0.01).结论 使用糖尿病看图对话工具提高了对糖尿病患者饮食、运动健康教育的近期和远期效果,为糖尿病教育增加了新的元素.%Objective To explore the effect of diabetic conversation map in diet and exercises education for diabetic patients.Methods A total of 214 diabetic patients were equally randomized into a traditional group and an observation group.The traditional group were given health education orally, while in the observation group, a well-designed conversation map was additionally employed to help patients grasp knowledge about diet and exercises.Results The test results of diet and exercises in the observation group were significiantly higher than those in the traditional group before discharge and three months after discharge (P<0.01 for all).HbA1C value in the observation group at the third month of discharge was signifieiantly lower than that in the traditional group (P<0.01).Conclusion Application of diabetic conversation map raises the short term and long term effect of diet and exercises education for diabetic patients, which adds new concept into diabetic education.

  15. Ethnic differences in diet: A focus on methodology, determinants and Type 2 Diabetes Mellitus

    NARCIS (Netherlands)

    Dekker, L.H.

    2015-01-01

    The overall aim of this thesis was to enhance the scientific basis for dietary analysis and the role of diet in T2DM prevalence in an ethnically diverse population. A large multi-ethnic population including five ethnic groups - South Asian origin Surinamese, African origin Surinamese, Turkish, Moroc

  16. The diet of free-roaming Australian Central Bearded Dragons (Pogona vitticeps).

    Science.gov (United States)

    Oonincx, D G A B; van Leeuwen, J P; Hendriks, W H; van der Poel, A F B

    2015-01-01

    The central bearded dragon (Pogona vitticeps) is one of the most popular pet lizards. However, little is known regarding their nutrient requirement, or their natural diet. Therefore, the stomach contents of 14 free-roaming P. vitticeps were determined by flushing. These stomach contents were described taxonomically, and analyzed for crude protein content as well as fatty acid content and composition. Most of the dry matter intake was in the form of animal material (61%) stemming from nine arthropod orders. The most abundant were alates of the termite Drepanotermes sp., accounting for 95% of the total number of prey items and more than half of the total dry matter (DM) intake. Plant material contributed 16% of the total DM intake. The diets were high in crude protein (41-50% DM) and the total fatty acid content was 14-27% of the DM intake. The main fatty acid was C18:1n9c (51-56% of total fatty acids), and polyunsaturated fatty acids (n3 and n6) comprised 6-8% of the total fat intake. Our data suggest that P. vitticeps is an opportunistic predator, which exploits the seasonal availability of prey. Based on our data and other studies, a diet consisting of several insect species, supplemented with leafy vegetables, rich in n3 FA's, would best resemble the expected natural diet of P. vitticeps. © 2015 Wiley Periodicals, Inc.

  17. A food additive with prebiotic properties of an α-d-glucan from lactobacillus plantarum DM5.

    Science.gov (United States)

    Das, Deeplina; Baruah, Rwivoo; Goyal, Arun

    2014-08-01

    An α-d-glucan produced by Lactobacillus plantarum DM5 was explored for in vitro prebiotic activities. Glucan-DM5 demonstrated 21.6% solubility, 316.9% water holding capacity, 86.2% flocculation activity, 71.4% emulsification activity and a degradation temperature (Td) of 292.2°C. Glucan-DM5 exhibited lowest digestibility of 0.54% by artificial gastric juice, 0.21% by intestinal fluid and 0.32% by α-amylase whereas the standard prebiotic inulin, showed 25.23%, 5.97% and 19.13%, hydrolysis, respectively. Prebiotic activity assay of glucan-DM5 displayed increased growth of probiotic bacteria such as Bifidobacterium infantis and Lactobacillus acidophilus, but did not support the growth of non-probiotic bacteria such as Escherichia coli and Enterobacter aerogenes. The overall findings indicated that glucan from L. plantarum DM5 can serve as a potential prebiotic additive for food products.

  18. Sustaining Effect of Intensive Nutritional Intervention Combined with Health Education on Dietary Behavior and Plasma Glucose in Type 2 Diabetes Mellitus Patients

    Directory of Open Access Journals (Sweden)

    Rui Fan

    2016-09-01

    Full Text Available Diabetes mellitus is very common in elderly Chinese individuals. Although nutritional intervention can provide a balanced diet, the sustaining effect on at-home dietary behavior and long-term plasma glucose control is not clear. Consequently, we conducted a long-term survey following one month of experiential nutritional intervention combined with health education. Based on the Dietary Guidelines for a Chinese Resident, we found that the food items met the recommended values, the percentages of energy provided from fat, protein, and carbohydrate were more reasonable after one year. The newly formed dietary patterns were “Healthy”, “Monotonous”, “Vegetarian”, “Japanese”, “Low energy”, and “Traditional” diets. The 2h-PG of female participants as well as those favoring the “Japanese diet” decreased above 12 mmol/L. Participants who selected “Japanese” and “Healthy” diets showed an obvious reduction in FPG while the FPG of participants from Group A declined slightly. “Japanese” and “Healthy” diets also obtained the highest DDP scores, and thus can be considered suitable for T2DM treatment in China. The results of the newly formed dietary patterns, “Japanese” and “Healthy” diets, confirmed the profound efficacy of nutritional intervention combined with health education for improving dietary behavior and glycemic control although health education played a more important role. The present study is encouraging with regard to further exploration of comprehensive diabetes care.

  19. Sustaining Effect of Intensive Nutritional Intervention Combined with Health Education on Dietary Behavior and Plasma Glucose in Type 2 Diabetes Mellitus Patients

    Science.gov (United States)

    Fan, Rui; Xu, Meihong; Wang, Junbo; Zhang, Zhaofeng; Chen, Qihe; Li, Ye; Gu, Jiaojiao; Cai, Xiaxia; Guo, Qianying; Bao, Lei; Li, Yong

    2016-01-01

    Diabetes mellitus is very common in elderly Chinese individuals. Although nutritional intervention can provide a balanced diet, the sustaining effect on at-home dietary behavior and long-term plasma glucose control is not clear. Consequently, we conducted a long-term survey following one month of experiential nutritional intervention combined with health education. Based on the Dietary Guidelines for a Chinese Resident, we found that the food items met the recommended values, the percentages of energy provided from fat, protein, and carbohydrate were more reasonable after one year. The newly formed dietary patterns were “Healthy”, “Monotonous”, “Vegetarian”, “Japanese”, “Low energy”, and “Traditional” diets. The 2h-PG of female participants as well as those favoring the “Japanese diet” decreased above 12 mmol/L. Participants who selected “Japanese” and “Healthy” diets showed an obvious reduction in FPG while the FPG of participants from Group A declined slightly. “Japanese” and “Healthy” diets also obtained the highest DDP scores, and thus can be considered suitable for T2DM treatment in China. The results of the newly formed dietary patterns, “Japanese” and “Healthy” diets, confirmed the profound efficacy of nutritional intervention combined with health education for improving dietary behavior and glycemic control although health education played a more important role. The present study is encouraging with regard to further exploration of comprehensive diabetes care. PMID:27649232

  20. Influence of Food Labels on Adolescent Diet.

    Science.gov (United States)

    Misra, Ranjita

    2002-01-01

    Provides information on food nutrition labels and discusses the benefits of adolescents' using them to plan healthy diets. Suggests that teachers and educators should encourage appropriate label reading education for adolescents to promote healthy eating practices. Provides definitions of nutrient content claims. (SG)

  1. High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions.

    Science.gov (United States)

    Hua, Yun; Strock, Christopher J; Johnston, Paul A

    2015-01-01

    This chapter describes the implementation of the p53-hDM2 protein-protein interaction (PPI) biosensor (PPIB) HCS assay to identify disruptors of p53-hDM2 PPIs. Recombinant adenovirus expression constructs were generated bearing the individual p53-GFP and hDM2-RFP PPI partners. The N-terminal p53 transactivating domain that contains the binding site for hDM2 is expressed as a GFP fusion protein that is targeted and anchored in the nucleolus of infected cells by a nuclear localization (NLS) sequence. The p53-GFP biosensor is localized to the nucleolus to enhance and facilitate the image acquisition and analysis of the PPIs. The N-terminus of hDM2 encodes the domain for binding to the transactivating domain of p53, and is expressed as a RFP fusion protein that includes both an NLS and a nuclear export sequence (NES). In U-2 OS cells co-infected with both adenovirus constructs, the binding interactions between hDM2 and p53 result in both biosensors becoming co-localized within the nucleolus. Upon disruption of the p53-hDM2 PPIs, the p53-GFP biosensor remains in the nucleolus while the shuttling hDM2-RFP biosensor redistributes into the cytoplasm. p53-hDM2 PPIs are measured by acquiring fluorescent images of cells co-infected with both adenovirus biosensors on an automated HCS imaging platform and using an image analysis algorithm to quantify the relative distribution of the hDM2-RFP shuttling component of the biosensor between the cytoplasm and nuclear regions of compound treated cells.

  2. Effect of Diet Experience Card on Dietary Education of Patients with Type 2 Diabetes Mellitus%饮食体验卡在2型糖尿病患者饮食教育中的应用

    Institute of Scientific and Technical Information of China (English)

    胡鹏; 陶静; 徐蓉

    2012-01-01

    目的 探讨饮食体验卡在2型糖尿病患者饮食健康教育中的应用效果.方法 189例2型糖尿病患者,分为观察组91例和对照组98例,观察组饮食教育时使用饮食体验卡,对照组使用常规的饮食教育.观察两组入院时、干预6个月时的体质量指数、糖化血红蛋白、血脂的变化;观察两组入院时、出院后3个月饮食问卷评分、住院期间饮食教育所需时间.结果 观察组干预6个月时体质量、糖化血红蛋白和血脂明显低于对照组(P=0.000);观察组住院期间饮食教育所需时间明显低于对照组(P=0.000),出院后3个月观察组饮食问卷评分低于对照组(P=0.000).结论 饮食体验卡能更好地促进2型糖尿病患者体质量、糖化血红蛋白和血脂的控制,提高患者饮食的依从性,并节约了责任护士的饮食教育时间.%Objective To explore the effect of diet experience card on dietary education of patients with type 2 diabetes mellitus. Methods A total of 189 patients with type 2 diabetes mellitus were divided into observation group (n=91) and control group (n=98). In observation group, diet experience card on dietary education was applied while in control group, conventional dietary education was conducted. BM1, HbAlc and blood lipid on admission and 6 months after intervention were observed. Diet, questionnaire score on admission and 3 months after discharge and dietary education time during hospitalization were compared as well. Results BMI. HbAlc and blood lipid in observation group 6 months alter intervention were significantly lower than those in control group (P=0.000). Patients in observation group took less dietary education time during hospitalization than that in control group did (P=0.000). And the diet questionnaire score 3 months after discharge of observation group was higher than that of control group (P=0.000). Conclusion Diet experience card could help patients with type 2 diabetes mellitus to control their

  3. Use of the N-alkanes to Estimate Intake, Apparent Digestibility and Diet Composition in Sheep Grazing on Stipa brevilfora Desert Steppe

    Institute of Scientific and Technical Information of China (English)

    HU Hong-lian; LIU Yong-zhi; LI Ya-kui; LU De-xun; GAO Min

    2014-01-01

    The application of n-alkane as markers to estimate herbage intake, apparent digestibility and species composition of diet consumed by grazing sheep was studied. Six local Mongolian sheep were used to determine dry matter (DM) intake, apparent DM digestibility and species composition of diet during summer, autumn and winter. Animals were orally dosed twice daily with n-alkane gelatin capsules containing 60 mg C32-alkane as an external marker. Diet composition was estimated by comparing the odd-chain n-alkanes pattern profile (C27-C31) of the consumed plant species with the n-alkanes fecal concentrations of grazing animals, using a non-negative least squares algorithm called EATWHAT software package. The alkane pair C32:C33 and C33 alkane were used to estimate DM intake and diet apparent DM digestibility, respectively. The results showed that daily dry matter intake of the sheep were 1.77, 1.61 and 1.18 kg d-1 in summer, autumn and winter, respectively. Apparent DM digestibility, crude protein (CP), metabolizable energy (ME) and neutral detergent ifber (NDF) intake of diet consumed by sheep decreased signiifcantly (P<0.01) from summer to winter, with no evident changes in ADF and ADL intake. Diet composition indicated Artemisia frigida Willd was the most dominant diet component, contributed 79.68, 68.12 and 86.26% of sheep’s diets in summer, autumn and winter, respectively. Cleistogenes songorica Ohwi and Convolvulus ammannii Desr were the important components of the diet. Although Stipa brevilfora Griseb is one of the main plant species in the study area, the sheep rarely choosed it. The study indicated that CP and ME in diet consumed by sheep were deifcient in winter. Therefore, appropriate supplementation strategies should be indispensable during this period.

  4. Impact of adding nitrate or increasing the lipid content of two contrasting diets on blood methaemoglobin and performance of two breeds of finishing beef steers.

    Science.gov (United States)

    Duthie, C-A; Rooke, J A; Troy, S; Hyslop, J J; Ross, D W; Waterhouse, A; Roehe, R

    2016-05-01

    Adding nitrate to the diet or increasing the concentration of dietary lipid are effective strategies for reducing enteric methane emissions. This study investigated their effect on health and performance of finishing beef cattle. The experiment was a two×two×three factorial design comprising two breeds (CHX, crossbred Charolais; LU, Luing); two basal diets consisting of (g/kg dry matter (DM), forage to concentrate ratios) 520 : 480 (Mixed) or 84 : 916 (Concentrate); and three treatments: (i) control with rapeseed meal as the main protein source replaced with either (ii) calcium nitrate (18 g nitrate/kg diet DM) or (iii) rapeseed cake (RSC, increasing acid hydrolysed ether extract from 25 to 48 g/kg diet DM). Steers (n=84) were allocated to each of the six basal diet×treatments in equal numbers of each breed with feed offered ad libitum. Blood methaemoglobin (MetHb) concentrations (marker for nitrate poisoning) were monitored throughout the study in steers receiving nitrate. After dietary adaptation over 28 days, individual animal intake, performance and feed efficiency were recorded for a test period of 56 days. Blood MetHb concentrations were low and similar up to 14 g nitrate/kg diet DM but increased when nitrate increased to 18 g nitrate/kg diet DM (P0.05). Neither basal diet nor treatment affected carcass quality (P>0.05), but CHX steers achieved a greater killing out proportion (Pnitrate to the diet or increasing the level of dietary lipid through the use of cold-pressed RSC, did not adversely affect health or performance of finishing beef steers when used within the diets studied.

  5. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF

    OpenAIRE

    Moy, Gregory A.; McNay, Ewan C.

    2012-01-01

    Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer’s disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration...

  6. Development of a pseudo phased array technique using EMATs for DM weld testing

    Energy Technology Data Exchange (ETDEWEB)

    Cobb, Adam C., E-mail: adam.cobb@swri.org; Fisher, Jay L., E-mail: adam.cobb@swri.org [Southwest Research Institute, Sensor Systems and Nondestructive Technology Department, 6220 Culebra Road, San Antonio, TX 78238-5166 (United States); Shiokawa, Nobuyuki; Hamano, Toshiaki; Horikoshi, Ryoichi; Ido, Nobukazu [IHI Corporation, Nuclear Power Operations, Yokohama Engineering Center, 1, Shin-Nakahara-cho, Isogo-ku, Yokohama 235-8501 (Japan)

    2015-03-31

    Ultrasonic inspection of dissimilar metal (DM) welds in piping with cast austenitic stainless steel (CASS) has been an area ongoing research for many years given its prevalence in the petrochemical and nuclear industries. A typical inspection strategy for pipe welds is to use an ultrasonic phased array system to scan the weld from a sensor located on the outer surface of the pipe. These inspection systems generally refract either longitudinal or shear vertical (SV) waves at varying angles to inspect the weld radially. In DM welds, however, the welding process can produce a columnar grain structure in the CASS material in a specific orientation. This columnar grain structure can skew ultrasonic waves away from their intended path, especially for SV and longitudinal wave modes. Studies have shown that inspection using the shear horizontal (SH) wave mode significantly reduces the effect of skewing. Electromagnetic acoustic transducers (EMATs) are known to be effective for producing SH waves in field settings. This paper presents an inspection strategy that seeks to reproduce the scanning and imaging capabilities of a commercial phase array system using EMATs. A custom-built EMAT was used to collect data at multiple propagation angles, and a processing strategy known as the synthetic aperture focusing technique (SAFT) was used to combine the data to produce an image. Results are shown using this pseudo phased array technique to inspect samples with a DM weld and artificial defects, demonstrating the potential of this approach in a laboratory setting. Recommendations for future work to transition the technique to the field are also provided.

  7. Development of a pseudo phased array technique using EMATs for DM weld testing

    Science.gov (United States)

    Cobb, Adam C.; Fisher, Jay L.; Shiokawa, Nobuyuki; Hamano, Toshiaki; Horikoshi, Ryoichi; Ido, Nobukazu

    2015-03-01

    Ultrasonic inspection of dissimilar metal (DM) welds in piping with cast austenitic stainless steel (CASS) has been an area ongoing research for many years given its prevalence in the petrochemical and nuclear industries. A typical inspection strategy for pipe welds is to use an ultrasonic phased array system to scan the weld from a sensor located on the outer surface of the pipe. These inspection systems generally refract either longitudinal or shear vertical (SV) waves at varying angles to inspect the weld radially. In DM welds, however, the welding process can produce a columnar grain structure in the CASS material in a specific orientation. This columnar grain structure can skew ultrasonic waves away from their intended path, especially for SV and longitudinal wave modes. Studies have shown that inspection using the shear horizontal (SH) wave mode significantly reduces the effect of skewing. Electromagnetic acoustic transducers (EMATs) are known to be effective for producing SH waves in field settings. This paper presents an inspection strategy that seeks to reproduce the scanning and imaging capabilities of a commercial phase array system using EMATs. A custom-built EMAT was used to collect data at multiple propagation angles, and a processing strategy known as the synthetic aperture focusing technique (SAFT) was used to combine the data to produce an image. Results are shown using this pseudo phased array technique to inspect samples with a DM weld and artificial defects, demonstrating the potential of this approach in a laboratory setting. Recommendations for future work to transition the technique to the field are also provided.

  8. Hopanoid-free Methylobacterium extorquens DM4 overproduces carotenoids and has widespread growth impairment

    Science.gov (United States)

    Muller, Emilie E. L.; Bringel, Françoise; Caroll, Sean M.; Pearson, Ann; Vuilleumier, Stéphane; Marx, Christopher J.

    2017-01-01

    Hopanoids are sterol-like membrane lipids widely used as geochemical proxies for bacteria. Currently, the physiological role of hopanoids is not well understood, and this represents one of the major limitations in interpreting the significance of their presence in ancient or contemporary sediments. Previous analyses of mutants lacking hopanoids in a range of bacteria have revealed a range of phenotypes under normal growth conditions, but with most having at least an increased sensitivity to toxins and osmotic stress. We employed hopanoid-free strains of Methylobacterium extorquens DM4, uncovering severe growth defects relative to the wild-type under many tested conditions, including normal growth conditions without additional stressors. Mutants overproduce carotenoids–the other major isoprenoid product of this strain–and show an altered fatty acid profile, pronounced flocculation in liquid media, and lower growth yields than for the wild-type strain. The flocculation phenotype can be mitigated by addition of cellulase to the medium, suggesting a link between the function of hopanoids and the secretion of cellulose in M. extorquens DM4. On solid media, colonies of the hopanoid-free mutant strain were smaller than wild-type, and were more sensitive to osmotic or pH stress, as well as to a variety of toxins. The results for M. extorquens DM4 are consistent with the hypothesis that hopanoids are important for membrane fluidity and lipid packing, but also indicate that the specific physiological processes that require hopanoids vary across bacterial lineages. Our work provides further support to emerging observations that the role of hopanoids in membrane robustness and barrier function may be important across lineages, possibly mediated through an interaction with lipid A in the outer membrane. PMID:28319163

  9. Intake and digestion of horned guan Oreophasis derbianus diets measured in three Mexican zoos.

    Science.gov (United States)

    Tovar, Gretel; Cornejo, Juan; Macek, Michael; Dierenfeld, Ellen S

    2009-07-01

    We conducted nutritional analyses of diets offered to and ingested by seven pairs of horned guans (Oreophasis derbianus) in three zoos. Digestibility was calculated with individually housed birds (n=1 at each zoo). Diets offered varied widely among institutions, both in ingredients fed as well as in nutrient composition. Feeding selectivity was evident through differences in composition of diets offered vs. consumed, with fruit (bananas, grape, and/or plantain) and avocado (when offered) highly preferred; green leaves, poultry pellets, and other vegetables comprised lesser proportions of the diet. All facilities fed 2-3X more food than consumed, allowing a great degree of choice of preferred items and potentially consumption of nutritionally imbalanced diets-in particular, mineral constituents. Diets were highly digestible; dry matter (DM) digestion coefficients ranged from 70 to approximately 90%; protein digestibility varied from 30 to 80%; fat was >90% digestible. Diet composition was compared with known nutritional requirements of domestic avian species, and feeding recommendations discussed. Despite the wide variability in nutrient composition of diets eaten (i.e. protein 6-10% of DM; fat 2-17% of DM), no overt health problems were noted and all pairs had successfully reproduced on these diets. It is suggested that horned guans may have nutrient requirements more similar to those suggested for other frugivorous birds than values determined for poultry as the physiologic model. Comparisons with native food items, as well as more detailed nutrient balance studies, may provide even better guidelines for captive management of this highly endangered species.

  10. Elephant grass ensiled with wheat bran compared with corn silage in diets for lactating goats

    Directory of Open Access Journals (Sweden)

    Jacianelly Karla da Silva

    2014-11-01

    Full Text Available The objective of this study was to evaluate the use of wheat bran as an additive in elephant-grass silage on intake and digestibility of the nutrients, ingestive behavior, and yield and chemical composition of milk. Eight goats with 45 days of lactation were distributed in a (4 × 4 Latin square design.The treatments consisted of corn silage (CS, elephant-grass silage without wheat bran (EGS, elephant-grass silage with 10% wheat bran (EGS+10%WB, and elephant-grass silage with 20% wheat bran (EGS+20% WB. There was no difference in dry matter (DM intake between diets EGS and CS in g d−1. However, the animals fed EGS+10%WB had lower DM and organic matter (OM intakes than the animals fed CS in g kg−1 d−1 of body weight. There were lower non-fiber carbohydrate and metabolize energy intakes by animals fed diets based on elephant-grass silages than those fed CS. The EGS+20%WB diet provided lower digestibility coefficients of DM, OM, crude protein, ether extract, neutral detergent fiber (NDF and digestible nutrients of the diet than the diet with CS. The NDF digestibility coefficient with diet EGS was greater than that obtained with diet CS. The diets with corn and elephant-grass silages provided similar milk yield levels. However, the animals fed diets based on EGS+20% WB produced less total-solids-corrected milk than the animals fed CS. No difference was found in the milk physicochemical properties and ingestive behavior of goats in this study. Corn silage can be replaced by elephant-grass silage harvested at 50 days of regrowth and elephant-grass silage with 10% wheat bran without influencing goat performance, behavioral variables, physiological variables, milk yield or the milk physicochemical properties.

  11. Exercise, diet, education, joint intervention on the impact of gestational diabetes%运动、饮食、教育联合干预对妊娠期糖尿病的影响

    Institute of Scientific and Technical Information of China (English)

    徐丽丹; 汪小娟; 秦家濂; 曾东良; 曹建华; 陈信

    2013-01-01

    目的:探讨运动、饮食、教育联合干预对妊娠期糖尿病的影响。方法:对124例妊娠期糖尿病患者进行运动、饮食、教育联合干预治疗,并对其疗效进行比较。结果:实验组50g 糖筛查水平明显低于对照组;实验组妊娠期糖尿病发生率明显低于对照组;实验组甘油三酯、游离脂肪酸水平明显低于对照组。结论:饮食和运动干预对妊娠期糖尿病孕妇血糖调控起重要作用,对妊娠期糖尿病治疗效果好,母婴并发症明显下降。%Objective: To investigate the exercise, diet, education, joint intervention on the impact of gestational diabetes. Methods:124 cases of gestational diabetes in patients with exercise, diet, education, joint intervention treatment, and to compare its efficacy. Results: The 50g glucose screening levels were significantly lower than the control group; experimental group, the incidence of gestational diabetes was significantly lower than the control group; experimental group, triglycerides, free fat y acid levels were significantly lower than the control group. Conclusion: diet and exercise intervention on gestational diabetes, pregnant women play an important role in regulating blood sugar, good therapeutic effect on gestational diabetes, maternal complications decreased significantly.

  12. Telemetry System Parameters and Bit Error Performance of NRZ and DM PCM/FM

    Science.gov (United States)

    1976-03-29

    MODEL 400 4·POLE, LINEAR L ________ J PHASE FILTER ANDOM OM PSEUDO·R 0 PSEUDO·RA R NDOM :’olRZ EMR 721 TELEMETRY RECOVERED PCM SEQUENCE BIT...with variable bit rate. The NRZ and DM signals were pseudo-random sequences of 2,047 bits. The pre- modulation filter was a four-pole, linear phase ... filter with adjustable bandwidth. RF transmitter devia- tion and RF attenuation were adjustable on the FM signal generator which was operated at

  13. Geoscience Laser Altimeter System (GLAS): Final Test Report of DM LHP TV Testing. Revised

    Science.gov (United States)

    Baker, Charles

    2000-01-01

    The Demonstration Model (DM) Loop Heat Pipe (LHP) was tested at Goddard Space Flight Center (GSFC) during September and October, 1999. The LHP system was placed in the Dynavac 36 in. chamber in Building 4. The test lasted for about 6 weeks. The LHP was built, designed, and manufactured at Dynatherm Corporation, Inc. In Hunt Valley, MD according to GSFC specifications. The purpose of the test was to evaluate the performance of a propylene LHP for the Geoscience Laser Altimetry System (GLAS) instrument application.

  14. T-DM1 Combo Graduates from I-SPY 2.

    Science.gov (United States)

    2016-06-01

    The combination of the antibody-drug conjugate ado-trastuzumab emtansine, or T-DM1, plus pertuzumab given prior to surgery outperformed standard therapy in women with HER2-positive breast cancer enrolled in the I-SPY 2 trial. The results, reported at the American Association for Cancer Research Annual Meeting 2016, suggest that the drug combination would be successful in a phase III trial, potentially leading to an effective, less toxic treatment option for women at risk for metastatic disease.

  15. The Treatment of Long - duaration DM Should Be Dominated by Treating Kidney

    Institute of Scientific and Technical Information of China (English)

    FENGJizhong

    2004-01-01

    Diabetes pertains to Xiaoke in TCM. It is divided into three kinds, namely, upper lung,middle stomach and lower kidney, its treatment is also divided into moistening lung, clearing away stomach-heat and nourishing the kidney accordingly. But to get the root of the matter, the treatment of long - duration DM should be dominated by nourishing kidney and fostering the Yin. According to this theory, the Xiao Tang Yin was formulated. If consideration can be given to other symptoms and flexible modification can be made,good effects were got always.

  16. High-Contrast Coronagraph Performance in the Presence of DM Actuator Defects

    Science.gov (United States)

    Sidick, Erkin; Shaklan, Stuart; Cady, Eric

    2015-01-01

    Deformable Mirrors (DMs) are critical elements in high contrast coronagraphs, requiring precision and stability measured in picometers to enable detection of Earth-like exoplanets. Occasionally DM actuators or their associated cables or electronics fail, requiring a wavefront control algorithm to compensate for actuators that may be displaced from their neighbors by hundreds of nanometers. We have carried out experiments on our High-Contrast Imaging Testbed (HCIT) to study the impact of failed actuators in partial fulfillment of the Terrestrial Planet Finder Coronagraph optical model validation milestone. We show that the wavefront control algorithm adapts to several broken actuators and maintains dark-hole contrast in broadband light.

  17. Right-handed sneutrinos as asymmetric DM and neutrino masses from neutrinophilic Higgs bosons

    CERN Document Server

    Mitropoulos, Pantelis

    2013-01-01

    We consider an extension of the Next-to-Minimal Supersymmetric Standard Model by three right-handed neutrinos and a pair of neutrinophilic Higgs superfields. The small neutrino masses arise naturally from a small vacuum expectation value of the additional Higgs fields (hence without lepton number violation), while the lightest right-handed sneutrinos can constitute asymmetric Dark Matter. The right-handed sneutrino and baryon asymmetries are connected through equilibrium processes in the early universe, explaining the coincidence of the DM and baryon abundances. We show that particle physics and astrophysical constraints are satisfied.

  18. Localized spin excitations in an antiferromagnetic spin system with D-M interaction

    Energy Technology Data Exchange (ETDEWEB)

    Evangeline Rebecca, T.; Latha, M. M., E-mail: lathaisaac@yahoo.com [Department of Physics, Women' s Christian College, Nagercoil 629 001 (India)

    2016-06-15

    The existence of localized spin excitations and spin deviations along the site in a one-dimensional antiferromagnet with Dzyaloshinski-Moriya (D-M) interaction has been studied using quasiclassical approximation. By introducing the Holstein-Primakoff bosonic representation of spin operators, the coherent state ansatz, and the time dependent variational principle, a discrete set of coupled nonlinear partial differential equations governing the dynamics is derived. Employing the multiple-scale method, one, two and three solitary wave solutions are constructed and depicted graphically.

  19. Implementation of area optimization precoder in a 40 Gb/s PolDM-DQPSK system

    Institute of Scientific and Technical Information of China (English)

    ZHOU Li-ming; ZHANG Yang-an; ZHANG Ming-lun; WANG Gai; ZHANG Jin-nan; HUANG Yong-qing; LI Ling

    2010-01-01

    @@ In this paper,a new model based on an improved Brent Kung(BK)parallel prefix network(PPN)algorithm is proposed and realized in the field programmable gate array(FPGA).This model is employed in the implementation of 20 Gb/s differential quadrature phase-shift keying(DQPSK)precoder in 40 Gb/s polarization division multiplex(PolDM)DQPSK system.In the computation process,the computation complexity(area)optimization with fan-out limited is achieved.In the implementation,770 FPGA slice registers are utilized,which save about 60% logic resources compared with the previous Kogge Stone(KS)algorithm.

  20. Diet and Nutrition

    Science.gov (United States)

    ... need to know about Wilson Disease Diet and Nutrition Food . . . . Adherence to a low copper diet is ... dysarthria; rigid dystonia; pseudobulbar palsy; seizures; migraine headaches; insomnia Psychiatric: Depression; neuroses; personality changes; psychosis Other symptoms: ...

  1. Diets that Work

    Science.gov (United States)

    ... and low-fat dairy products. It excludes white flour products and most starchy carbohydrates like potatoes, rice, ... grains. Other vegetarians might include fish but no meat. A vegan diet is a diet that excludes ...

  2. Diet - chronic kidney disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002442.htm Diet - chronic kidney disease To use the sharing features on this page, ... make changes to your diet when you have chronic kidney disease. These changes may include limiting fluids, eating a ...

  3. Caffeine in the diet

    Science.gov (United States)

    Diet - caffeine ... Caffeine is absorbed and passes quickly into the brain. It does not collect in the bloodstream or ... been consumed. There is no nutritional need for caffeine. It can be avoided in the diet. Caffeine ...

  4. The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

    OpenAIRE

    Derkach, Kira V.; Bondareva, Vera M.; Oxana V. Chistyakova; Berstein, Lev M.; Alexander O. Shpakov

    2015-01-01

    In the last years the treatment of type 2 diabetes mellitus (DM2) was carried out using regulators of the brain signaling systems. In DM2 the level of the brain serotonin is reduced. So far, the effect of the increase of the brain serotonin level on DM2-induced metabolic and hormonal abnormalities has been studied scarcely. The present work was undertaken with the aim of filling this gap. DM2 was induced in male rats by 150-day high-fat diet and the treatment with low dose of streptozotocin (...

  5. Effects of dry, wet, and rehydrated corn bran and corn processing method in beef finishing diets.

    Science.gov (United States)

    Macken, C N; Erickson, G E; Klopfenstein, T J; Milton, C T; Stock, R A

    2004-12-01

    Two finishing trials were conducted to determine the effects of adding different types of corn bran, a component of corn gluten feed, on cattle performance. In Trial 1, 60 English crossbred yearling steers (283 +/- 6.7 kg) were used in a completely randomized design with four dietary treatments. Treatments were diets with no corn bran, dry corn bran (86% DM), wet corn bran (37% DM), and rehydrated dry bran (37% DM). Bran was fed at 40% of dietary DM. All finishing diets had (DM basis) 9% corn steep liquor with distillers solubles, 7.5% alfalfa hay, 3% tallow, and 5% supplement. Gain efficiency and ADG were greater (P < 0.01) for cattle fed no corn bran compared with all treatments containing corn bran; however, no differences were detected across corn bran types. In Trial 2, 340 English crossbred yearling steers (354 +/- 0.6 kg) were used in a randomized block design with treatments assigned based on a 2 x 4 + 2 factorial arrangement (four pens per treatment). One factor was the corn processing method used (dry-rolled corn, DRC; or steam-flaked corn, SFC). The other factor was corn bran type: dry (90% DM), wet (40% DM), or dry bran rehydrated to 40 or 60% DM. Bran was fed at 30% of dietary DM, replacing either DRC or SFC. Two control diets (DRC and SFC) were fed with no added bran. All finishing diets contained (DM basis) 10% corn steep liquor with distiller's solubles, 3.5% alfalfa hay, 3.5% sorghum silage, and 5% supplement. Corn bran type did not affect DMI (P = 0.61), ADG (P = 0.53), or G:F (P = 0.10). Dry matter intake was greater (P < 0.01) by steers fed bran compared with those fed no bran, and was greater by steers fed DRC than by steers fed SFC (P < 0.01). Interactions occurred (P < 0.01) between grain source and bran inclusion for ADG and G:F. The ADG by steers fed the SFC diet without bran was greater (P < 0.01) than by steers fed SFC diets with bran, whereas the ADG by steers fed DRC diets with or without bran was similar. Daily gain was 15.2% greater

  6. Type 2 diabetes mellitus non-genetic Rhesus monkey model induced by high fat and high sucrose diet.

    Science.gov (United States)

    Lu, Shuai-yao; Qi, Su-dong; Zhao, Yuan; Li, Yan-yan; Yang, Feng-mei; Yu, Wen-hai; Jin, Ma; Chen, Li-Xiong; Wang, Jun-bin; He, Zhan-long; Li, Hong-jun

    2015-01-01

    To build an ideal animal model for studying the mechanism of occurrence, developing and treating of diabetes become a more important issue, facing with the fact that the big threat of diabetes to human health has been worsen. First, we used the normal control diets or the high-fat/high-sucrose diets to feed the adult rhesus monkeys and the macaques induced by the high-fat/high-sucrose diets in the high-fat/high-sucrose group and the type 2 diabetes mellitus (T2DM) group developed the hyperglycemia, hyperinsulinemia at 6 months in accordance with the precious researches that reported that minipigs, rats and mice could develop hyperglycemia, hyperinsulinemia, hyperlipidemia and obesity after being induced with high-fat/high-carbohydrate diets. Second, the rhesus monkeys in T2DM group were injected STZ at a low dosage of 35 mg/kg BW to induce glucose persistent elevation which maintained pretty well after 12 months. Third, we took the assay of glucose tolerance test and insulin resistance index, assessed the changing tendency of serum resistin and analysed the pathological characteristics of the tissues like pancreas and liver by staining in different ways. The results indicate the rhesus monkeys in T2DM group have lots of clinical features of T2DM. The experimental non-genetic T2DM rhesus monkeys model not only contribute to simulating of clinical manifestations and pathological features of human T2DM, but also may be a good kind of model for research on the treatment of T2DM and for new drugs evaluation.

  7. Ketogenic Diets and Pain

    Science.gov (United States)

    Masino, Susan A.; Ruskin, David N.

    2014-01-01

    Ketogenic diets are well-established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain. PMID:23680946

  8. Ketogenic Diets and Pain

    OpenAIRE

    Masino, Susan A.; Ruskin, David N.

    2013-01-01

    Ketogenic diets are well-established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.

  9. Soybean hull and enzyme inclusion effects on diet digestibility and growth performance in beef steers consuming corn-based diets.

    Science.gov (United States)

    Russell, J R; Sexten, W J; Kerley, M S

    2016-06-01

    A beef feedlot study was conducted to determine the effects of increasing soybean hull (SH) inclusion and enzyme addition on diet digestibility and animal performance. The hypothesis was SH inclusion and enzyme addition would increase fiber digestibility with no negative effect on animal performance. Eight treatments (TRT) were arranged in a 4 × 2 factorial using four diets and two enzyme (ENZ) inclusion rates. The diets were composed primarily of whole shell corn (WSC) with 0%, 7%, 14%, or 28% SH replacing corn. The ENZ was a commercial proprietary mix of , and (Cattlemace, R&D Life Sciences, Menomonie, WI) included in the diets at 0% (S0, S7, S14, S28) or 0.045% DM basis (S0e, S7e, S14e, S28e). Eighty steers (287 ± 31 kg, SD) were stratified by weight and blocked into pens with 1 heavy and 1 light pen per TRT (2 pen/TRT, 5 steers/pen). Steers were fed for 70 d with titanium dioxide included in the diets for the final 15 d. Fecal samples were collected on d 70 to determine diet digestibility. Diets were balanced for AA and RDP requirement based on available ME. Individual DMI was measured using a GrowSafe system. Diet, ENZ, and diet × ENZ effects were analyzed using the MIXED procedure of SAS. Initial BW was applied as a covariate for final BW (FBW), and DMI was included as a covariate for all digestibility measures. The diet × ENZ interaction had no effect on FBW, ADG, DMI, or any digestibility measure ( ≥ 0.11). Steers fed ENZ tended to have greater FBW ( = 0.09) and had numerically greater ADG than steers not fed ENZ. Diet influenced DMI ( diets had the greatest DMI ( ≤ 0.3), steers fed S0 diets had the least DMI ( ≤ 0.002), and DMI of steers fed S14 and S28 diets did not differ ( = 0.5). There was a diet × ENZ interaction for G:F ( = 0.02) in which S0, S0e, S14e, and S28e did not differ ( ≥ 0.3) and were greatest ( ≤ 0.05). There was no effect of diet or ENZ on DM, OM, or CP digestibility ( ≥ 0.2). Diet had an effect on NDF and ADF

  10. Diet and Your Liver

    Science.gov (United States)

    ... and to do them for a long time. Eating an unhealthy diet can lead to liver disease. For example, ... and can help repair some liver damage. An unhealthy diet can make the liver ... diet include? • Eating foods from all the food groups: grains, proteins, ...

  11. Diet induced thermogenesis

    NARCIS (Netherlands)

    Westerterp, K.R.

    2004-01-01

    OBJECTIVE: Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and characteristics of the diet. METHODS: Measuring c

  12. Diet induced thermogenesis

    NARCIS (Netherlands)

    Westerterp, K.R.

    2004-01-01

    OBJECTIVE: Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and characteristics of the diet. METHODS: Measuring

  13. Diet induced thermogenesis

    NARCIS (Netherlands)

    Westerterp, K.R.

    2004-01-01

    OBJECTIVE: Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and characteristics of the diet. METHODS: Measuring c

  14. Feeding motivation and plasma metabolites in pregnant sows fed diets rich in dietary fiber either once or twice daily.

    Science.gov (United States)

    Jensen, M B; Pedersen, L J; Theil, P K; Yde, C C; Bach Knudsen, K E

    2012-06-01

    The present study investigated the effects of source and level of dietary fiber (DF) and feeding frequency (once vs. twice daily) on feeding motivation and plasma metabolites at 4 different time points post feeding. Sixty pregnant sows (Sus scrofa, 4 blocks of 15 sows) were allocated to 1 of 5 diets within blocks. Four diets were restricted (approximately 35 MJ ME/d): a barley and wheat control diet (171 g DF/kg DM; 12 g DF/MJ ME), and 3 fiber diets formulated to contain 35% DF by including pectin residue (323 g DF/kg DM; 25 g DF/MJ ME), potato pulp (404 g DF/kg DM; 29 g DF/MJ ME), or sugar beet pulp (367 g DF/kg DM; 25 g DF/MJ ME). The fifth diet was a mixture including an equal amount of the 3 fiber diets offered semi ad libitum (ad libitum access to feed during 6 periods of 1 h starting at 0300, 0600, 1100, 1500, 1800, and 2300; 354 g DF/kg DM; 25 g DF/MJ ME). The experimental period included 2 periods of 4 wk each. Restricted-fed sows were fed once daily (0800 h) during the first period and twice daily (0800 and 1500 h) during the second period, or vice versa. Semi ad libitum fed sows had access to feed 6 times a day in both periods. In each period, the feeding motivation was assessed in an operant conditioning test, and samples of peripheral blood were taken in a balanced design, at 0900, 1200, 1900, and 0700 h, corresponding to 1, 4, 11, and 23 h after feeding for restricted sows fed once daily. No differences in the feeding motivation were found between the 4 restricted diets at any of the time points post feeding, but semi ad libitum fed sows had a decreased feeding motivation (P fiber diets compared with the control (P = 0.02). Nonesterified fatty acid was least in sows on the control diet and greatest in sows on the potato diet, whereas sows on the pectin and sugar beet diets were intermediate (P fiber diets. In spite of the found effects on plasma metabolites, the applied level of fiber in the diet of restrictedly fed sows did not reduce their feeding

  15. Effect of wheat forage maturity and preservation method on forage chemical composition and performance of growing calves fed mixed diets.

    Science.gov (United States)

    Beck, P A; Stewart, C B; Gray, H C; Smith, J L; Gunter, S A

    2009-12-01

    Three 2.4-ha wheat (Triticum aestivum L.) fields were used to test the effects of maturity at harvest (boot vs. dough) and preservation method (hay vs. silage) on forage yield, chemical composition, and animal performance when fed in mixed diets. Forages were incorporated into 4 diets in a 2 x 2 factorial arrangement of treatments with hominy feed, soybean hulls, and cottonseed meal as the primary concentrate ingredients. In Exp. 1 diets contained 20% wheat forage (DM basis) and were fed to 96 beef calves (n = 48 steers and 48 heifers; initial BW 229 +/- 6.0 kg) in 12 mixed-sex pens. In Exp. 2 diets contained 40% wheat forage (DM basis) and were fed to beef steers (n = 48; initial BW 198 +/- 6.8 kg) in 12 pens. These diets were also individually fed to 32 calves (Exp. 1, n = 16, BW = 187 +/- 9.4 kg; Exp. 2, n = 16 calves, BW = 160 +/- 8.2 kg) to determine DM and NDF digestibility and gastrointestinal tract passage kinetics. Advanced maturity increased (P or= 0.22) NDF, ADF, or TDN concentrations. Maturity at harvest, preservation method, or their interaction did not affect (P >or= 0.15) ADG when wheat forage was fed as 20 or 40% of the diet. When calves were fed the 40% wheat forage diets, maturity at harvest did not affect (P >or= 0.27) DMI or G:F. Calves fed 40% hay diets consumed more (P = 0.04) feed DM as a percentage of BW than calves fed silage diets, but tended (P = 0.09) to be less efficient. With 20 or 40% wheat forage diets, there were no differences (P >or= 0.13) in passage rate, ruminal retention time, or fecal output due to maturity or preservation method. Digestibility of DM tended (P = 0.07) to be greater for silage than hay diets when fed in 20% wheat forage diets. Dry matter and NDF digestibility of 40% boot-stage wheat forage diets were greater (P wheat forage.

  16. Effect of water addition on selective consumption (sorting) of dry diets by dairy cattle.

    Science.gov (United States)

    Leonardi, C; Giannico, F; Armentano, L E

    2005-03-01

    The objective of this study was to determine whether adding water to a dry diet would reduce sorting and improve cow performance. Eighteen multiparous lactating Holstein cows were used in a cross-over design with 21-d periods. Treatments had the same dietary composition and differed only by adding water (WET) or not (DRY). Diets consisted of 10% alfalfa silage, 30% hay (approximately 80% grass and 20% alfalfa), and 60% concentrate [dry matter (DM) basis]. Dietary DM was 80.8% for DRY and 64.4% for WET. Both diets contained 16.9% crude protein and 24.3% neutral detergent fiber. Particle size was determined using the Wisconsin Particle Size Separator on the as-fed diets. The separator has five square-hole screens (Y(1) to Y(5)) with diagonal openings of 26.9 mm for Y(1), 18 mm for Y(2), 8.98 mm for Y(3), 5.61 mm for Y(4), and 1.65 mm for Y(5), and one pan. Sorting was calculated on a 60 degrees C DM basis (60DM). Predicted intake of Y(i) was calculated as the product of 60DM intake (60DMI) and the 60DM fraction of Y(i) in the total mixed ration for that screen. For DRY and WET, actual 60DMI by screen expressed as a percentage of predicted intake was 61.4% vs. 75.2% for Y(1), 83.8% vs. 98.6% for Y(2), 85.6% vs. 90.8% for Y(3), 95.2% vs. 96.0% for Y(4), 100.1% vs. 101.9% for Y(5), and 105.9% vs. 102.9% for pan, respectively. Adding water did not affect total DM intake (28.3 kg/d) or milk production (41.3 kg/d). Neutral detergent fiber intake was 6.42 kg/d for WET and 6.15 kg/d for DRY. Milk fat percentage tended to be higher (3.41% vs. 3.31%) when cows consumed WET vs. DRY. No differences in ruminal pH, NH(3), and volatile fatty acids were observed. Cows sorted against long particles in favor of shorter particles on both diets. Adding water to dry diets reduced sorting and tended to increase neutral detergent fiber intake and milk fat percentage.

  17. A rapid polymerase chain reaction-based test for screening Steinert′s disease (DM1

    Directory of Open Access Journals (Sweden)

    Hamzi Khalil

    2010-01-01

    Full Text Available Myotonic dystrophy (DM is a multisystemic neuromuscular disorder caused by a dynamic mutation of (CTG trinucleotide repeats in the 3′ untranslated region of the myotonic dystrophy protein kinase gene (DMPK. The aim of the present study was to establish the use of polymerase chain reaction (PCR-based simple and rapid method for initial sample screening. Only a minority of samples were tested positive with the above method and need to be detected by tri primer (TP-PCR and Southern blotting which is more time consuming and involves use of radioactive material. This study concerned 24 patients from nine families with a clinical diagnosis of the DM1. DNA extracted from the blood was used for amplification of the triplet repeat sequences at the DMPK loci. We obtained two bands for the normal subjects and one band for patients corresponding to normal DMPK allele, confirmed by the TP-PCR and the Southern blot. This rapid test for initial screening of samples for the presence of DMPK mutations is economical and reliable method. This method reduces the number of samples needing TP-PCR and Southern blotting.

  18. TREX-DM: a low background Micromegas-based TPC for low mass WIMP detection

    CERN Document Server

    Iguaz, F J; Aznar, F; Castel, J F; Cebrian, S; Dafni, T; Garcia, J A; Gomez, H; Gonzalez-Diaz, D; Irastorza, I G; Lagraba, A; Luzon, G; Peiro, A; Rodriguez, A

    2015-01-01

    Dark Matter experiments are recently focusing their detection techniques in low-mass WIMPs, which requires the use of light elements and low energy threshold. In this context, we present the TREX-DM experiment, a low background Micromegas-based TPC for low-mass WIMP detection. Its main goal is the operation of an active detection mass $\\sim$0.300 kg, with an energy threshold below 0.4 keVee and fully built with previously selected radiopure materials. This article describes the actual setup, the first results of the comissioning in Ar+2\\%iC$_4$H$_{10}$ at 1.2 bar and the future updates for a possible physics run at the Canfranc Underground Laboratory in 2016. A first background model is also presented, based on Geant4 simulations and a muon/electron discrimination method. In a conservative scenario, TREX-DM could be sensitive to DAMA/LIBRA and other hints of positive WIMPs signals, with some space for improvement with a neutron/electron discrimination method or the use of other light gases.

  19. PPPC 4 DM ID: a poor particle physicist cookbook for dark matter indirect detection

    Energy Technology Data Exchange (ETDEWEB)

    Cirelli, Marco; Panci, Paolo; Strumia, Alessandro [CERN Theory Division, CH-1211 Geneve (Switzerland); Corcella, Gennaro [Museo Storico della Fisica, Centro Studi e Ricerche E. Fermi, P. del Viminale 1, I-00185 Rome (Italy); Hektor, Andi; Kadastik, Mario; Raidal, Martti [National Institute of Chemical Physics and Biophysics, Ravala 10, 10143 Tallinn (Estonia); Hütsi, Gert [Tartu Observatory, Tõravere 61602 (Estonia); Sala, Filippo, E-mail: marco.cirelli@cea.fr [Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy)

    2011-03-01

    We provide ingredients and recipes for computing signals of TeV-scale Dark Matter annihilations and decays in the Galaxy and beyond. For each DM channel, we present the energy spectra at production, computed by high-statistics simulations. We estimate the Monte Carlo uncertainty by comparing the results yielded by the Pythia and Herwig event generators. We then provide the propagation functions for charged particles in the Galaxy, for several DM distribution profiles and sets of propagation parameters. Propagation of e{sup ±} is performed with an improved semi-analytic method that takes into account position-dependent energy losses in the Milky Way. Using such propagation functions, we compute the energy spectra of e{sup ±}, p-bar and d-bar at the location of the Earth. We then present the gamma ray fluxes, both from prompt emission and from Inverse Compton scattering in the galactic halo. Finally, we provide the spectra of extragalactic gamma rays. All results are available in numerical form and ready to be consumed.

  20. Micromegas for dark matter searches: CAST/IAXO & TREX-DM

    CERN Document Server

    Garza, J G; Castel, J.F.; Cebrián, S.; Dafni, T.; Ferrer-Ribas, E.; Galán, J.; García, J.A.; Giomataris, I.; Iguaz, F.J.; Irastorza, I.G.; Luzón, G.; Mirallas, H.; Papaevangelou, T.; Peiró, A.; Tomás, A.; Vafeiadis, T.

    2016-01-01

    The most compelling candidates for Dark Matter to day are WIMPs and axions. The applicability of gasesous Time Projection Chambers (TPCs) with Micromesh Gas Structures (Micromegas) to the search of these particles is explored within this work. Both particles would produce an extremely low rate at very low energies in particle detectors. Micromegas detectors can provide both low background rates and low en- ergy threshold, due to the high granularity, radiopurity and uniformity of the readout. Small (few cm wide) Micromegas detectors are used to image the axion-induced x-ray signal expected in the CERN Axion Solar Telescope (CAST) experiment. We show the background levels obtained in CAST and the prospects to further reduce them to the values required by the Internation Axion Observatory (IAXO). We also present TREX-DM, a scaled-up version of the Micromegas used in axion research, but this time dedicated to the low-mass WIMP detection. TREX-DM is a high-pressure Micromegas-based TPC designed to host a few hund...

  1. Chromospheric activity on late-type star DM UMa using high-resolution spectroscopic observations

    CERN Document Server

    Zhang, LiYun; Han, Xianming L; Chang, Liang; Wang, Daimei

    2016-01-01

    We present new 14 high-resolution echelle spectra to discuss the level of chromospheric activity of DM UMa in {He I} D3, {Na I} D1, D2, Halpha, and {Ca II} infrared triplet lines (IRT). It is the first time to discover the emissions above the continuum in the {He I} D3 lines on 2015 February 9 and 10. The emission on February 9 is the strongest one ever detected for DM UMa. We analysed these chromospheric active indicators by employing the spectral subtraction technique. The subtracted spectra reveal weak emissions in the {Na I} D1, D2 lines, strong emission in the Halpha line, and clear excess emissions in the {Ca II} IRT lines. Our values for the EW8542/EW8498 ratio are on the low side, in the range of 1.0-1.7. There are also clear phase variations of the level of chromospheric activity in equivalent width (EW) light curves in these chromospheric active lines (especially the Halpha line). These phenomena might be explained by flare events or rotational modulations of the level of chromospheric activity.

  2. SOLA-DM: A numerical solution algorithm for transient three-dimensional flows

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, T.L.; Nichols, B.D.; Hirt, C.W.; Stein, L.R.

    1988-02-01

    SOLA-DM is a three-dimensional time-explicit, finite-difference, Eulerian, fluid-dynamics computer code for solving the time-dependent incompressible Navier-Stokes equations. The solution algorithm (SOLA) evolved from the marker-and-cell (MAC) method, and the code is highly vectorized for efficient performance on a Cray computer. The computational domain is discretized by a mesh of parallelepiped cells in either cartesian or cylindrical geometry. The primary hydrodynamic variables for approximating the solution of the momentum equations are cell-face-centered velocity components and cell-centered pressures. Spatial accuracy is selected by the user to be first or second order; the time differencing is first-order accurate. The incompressibility condition results in an elliptic equation for pressure that is solved by a conjugate gradient method. Boundary conditions of five general types may be chosen: free-slip, no-slip, continuative, periodic, and specified pressure. In addition, internal mesh specifications to model obstacles and walls are provided. SOLA-DM also solves the equations for discrete particle dynamics, permitting the transport of marker particles or other solid particles through the fluid to be modeled. 7 refs., 7 figs.

  3. DM/DE revealed: The physical origin of Lambda-CDM

    Science.gov (United States)

    Beichler, James

    2009-10-01

    In the past few decades two new `crises' affecting fundamental physics have emerged in the observation of phenomena that indicate the existence of Dark Matter and Dark Energy. These are not problems which can be solved by quantum theory or particles, but rather problems that are related to gravity theory as expressed by the general theory of relativity. Numerous ideas and hypotheses have been suggested to explain these new problematic phenomena, but no particular hypothesis or resulting model has proven satisfactory. No model yet proposed seems to be able to explain either DM and DE or both even though theoretical physicists generally agree that the two should have a single common explanation. There is, however, one relatively unknown exception that can explain both DM and DE without any additional hypotheses and this model explains the physical origins of the Lambda-CDM term that others have already proposed adding to general relativity. Yet this new model is not without consequences for the rest of physics and science: Accepting this new model would mean acknowledging the existence of a higher space-like dimension in addition to our normal four-dimensions of space-time.

  4. An estimate of the DM profile in the Galactic bulge region

    CERN Document Server

    Iocco, Fabio

    2016-01-01

    We present an analysis of the mass distribution in the region of the Galactic bulge, which leads to constraints on the total amount and distribution of Dark Matter (DM) therein. Our results -based on the dynamical measurement of the BRAVA collaboration- are quantitatively compatible with those of a recent analysis, and generalised to a vaste sample of observationally inferred morphologies of the stellar components in the region of the Galactic bulge. By fitting the inferred DM mass to a generalised NFW profile, we find that cores (index gamma smaller than 0.6) are forbidden only for very light configurations of the bulge, and that cusps (index gamma bigger than 1.2) are allowed, but not necessarily preferred. Interestingly, we find that the results for the bulge region are compatible with those obtained with dynamical methods (based on the rotation curve) applied to outer regions of the Milky Way, for all morphologies adopted. We find that the uncertainty on the shape of the stellar morphology heavily affects...

  5. Identification of an extracellular antifungal protein from the endophytic fungus Colletotrichum sp. DM06.

    Science.gov (United States)

    Dey, Prabuddha; Kamdar, Maulik R; Mandal, Santi M; Maiti, Mrinal K

    2013-02-01

    An extracellular antifungal protein of 28 kDa (exAFP-C28) was identified from an endophytic fungus Colletotrichum sp. DM-06. After purification, the MIC value of exAFP-C28 against Candida albicans, a well-known human pathogenic fungus was found to be 32 μg/mL that unaffected the human red blood cells. The antifungal activity associated with exAFP-C28 was manifested by the increased membrane permeability of C. albicans cells followed by disruption. Proteomics and bioinformatics analyses revealed that several peptide fragments of exAFP-C28 have identity with the bacterial 50S ribosomal protein L10, and a stretch of 55 amino acids of two peptide fragments corresponding to the Nterminus of L10 protein is capable of forming amphipathic helix required for membrane penetration. Taken together, our results suggest that the exAFP-C28 protein from Colletotrichum sp. DM-06 is a promising therapeutic agent in controlling candidiasis disease in animals including humans.

  6. Measurement of the attenuation length of argon scintillation light in the ArDM LAr TPC

    CERN Document Server

    Calvo, J; Crivelli, P; Daniel, M; DiLuise, S; Gendotti, A; Horikawa, S; Molina-Bueno, L; Montes, B; Mu, W; Murphy, S; Natterer, G; Ngyuen, K; Periale, L; Quan, Y; Radics, B; Regenfus, C; Romero, L; Rubbia, A; Santorelli, R; Sergiampietri, F; Viant, T; Wu, S

    2016-01-01

    We report on a measurement of the attenuation length for the scintillation light in the tonne size liquid argon target of the ArDM dark matter experiment. The data was recorded in the first underground operation of the experiment in single-phase operational mode. The results were achieved by comparing the light yield spectra from 39-Ar and 83m-Kr to a description of the ArDM setup with a model of full light ray tracing. A relatively low value close to 0.5 m was found for the attenuation length of the liquid argon bulk to its own scintillation light. We interpret this result as a presence of optically active impurities in the liquid argon which are not filtered by the installed purification systems. We also present analyses of the argon gas employed for the filling and discuss cross sections in the vacuum ultraviolet of various molecules in respect to purity requirements in the context of large liquid argon installations.

  7. CMIN — a CRISP-DM-based case tool for supporting data mining projects

    Directory of Open Access Journals (Sweden)

    Carlos Cobos

    2010-10-01

    Full Text Available This paper introduces CMIN, an integrated computer aided software engineering (CASE tool based on cross-industry standard process for data mining (CRISP-DM 1.0 designed to support carrying out data mining projects. It is “integrated” in the sense that it supports all phases of a process. A general overview of how CMIN works is presented first, including a treatment of processes, templates and project management. CMIN’s capacity for easily and intuitively monitoring projects is highlighted, as is the manner in which CMIN allows a user to increase knowledge regarding using CRISP-DM or any other process defined in the CASE tool through the help and information presented in each step. Next, it is shown how CMIN can bind new data mining algorithms in runtime (without the need to recompile the tool to support modelling tasks (based on a Workflow and evaluate data mining projects. Finally, the results of two evaluations of the tool, some conclusions and suggestions for future work are presented.

  8. Non-diabetic renal disease (NDRD) in patients with type 2 diabetes mellitus (type 2 DM).

    Science.gov (United States)

    Prakash, Jai

    2013-03-01

    In contrast to Type 1 diabetes mellitus (DM), the incidence of non-diabetic renal disease (NDRD) is very high in Type 2 diabetic patients. A wide spectrum of non-diabetic nephropathy (NDN) including both glomerular and tubulointerstitial lesions are reported in patients with Type 2 DM and their precise diagnosis requires histological examination of kidney tissue. Renal biopsy studies suggest that 25-50% of patients with Type 2 diabetes had glomerular lesions unrelated to or in addition to diabetic nephropathy. Histological studies confirm that NDRD can occur in isolated form without diabetic nephropathy or superimposed on diabetic nephropathy. Diabetic nephropathy can occur in absence of retinopathy and chance of getting diabetic and non-diabetic renal lesions are nearly equal in Type 2 diabetic patient in absence of diabetic retinopathy (RP). The presence of RP suggests the concurrence of DN, but does not exclude non-diabetic nephropathy. Clearly, renal biopsy is indicated in proteinuric Type 2 diabetic patients for precise diagnosis of diabetic vs non-diabetic renal disease. Appropriate treatment of NDRD is associated with good clinical outcome. Thus, it is gratifying to treat NDRD in selected patients. Besides, 40 to 60% of ESRD in Type 2 diabetic patients is not caused by diabetic nephropathy.

  9. Efek perlindungan kombinasi kuersetin dan omega-3 terhadap sel β pankreas tikus dm tipe 2

    Directory of Open Access Journals (Sweden)

    Asri Hendrawati

    2017-06-01

    Full Text Available Diabetes mellitus (DM is a metabolic disease that causes damage pancreatic cells. Quercetin and omega-3 widely studied as an adjunctive therapy in DM because it can reduce oxidative stress and prevent cell damage. The aim of the study was to measure the ability of quercetin and omega-3 combination in protecting pancreatic β-cells in diabetic rats. Subjects consisted of 28 rats, divided into 1 healthy group and 6 diabetic groups (4 rats per group. The tested materials are quercetin doses 5, 20 and 80 mg/kg/day and omega-3 doses 25, 100 and 400mg/kg /day orally for 4 weeks. After treatment, the pancreatic tissue was taken for hematoxylin-eosin staining and be calculated the percentage of it damage. In this research, combination of quercetin 80mg/kg/day and omega-3 400 mg /kg/day lowered levels of destructionof pancreatic β cells significantly better than a smaller dose combination or without the combination (p<0,05. So, combination of quercetin 80 mg/kg/day and omega-3 400 mg/kg/day lowered levels of destruction of pancreatic β-cells most significantly better than a smaller ose combination or without the combination.

  10. Evolution of protoplanetary disks: Constraints from DM Tauri and GM Aurigae

    CERN Document Server

    Hueso, R; Hueso, Ricardo; Guillot, Tristan

    2005-01-01

    We present a one-dimensional model of the formation and viscous evolution of protoplanetary disks. The formation of the early disk is modeled as the result of the gravitational collapse of an isothermal molecular cloud. The disk's viscous evolution is integrated according to two parameterizations of turbulence: The classical $\\alpha$ representation and a $\\beta$ parameterization, representative of non-linear turbulence driven by the keplerian shear. We apply the model to DM Tau and GM Aur, two classical T-Tauri stars with relatively well-characterized disks, retrieving the evolution of their surface density with time. We perform a systematic Monte-Carlo exploration of the parameter space (i.e. values of the $\\alpha$-$\\beta$ parameters, and of the temperature and rotation rate in the molecular cloud) to find the values that are compatible with the observed disk surface density distribution, star and disk mass, age and present accretion rate. We find that the observations for DM Tau require $0.001<\\alpha<...

  11. [Functional activity of the modA, gene in Methylobacterium dichloromethanicum DM4].

    Science.gov (United States)

    Firsova, Y E; Trotsenko, Y A

    2014-01-01

    The putative METDI2644 (modA2) gene of Methylobacterium dichloromethanicum DM4, present in the 126-kbp chromosomal fragment associated with dichloromethane (DCM) degradation was investigated. While this gene is presumed to encode the periplasmic substrate-binding subunit of the molybdate ABC transporter, its conceptual translation also exhibits similarity to the proteins containing the ostA conservative domain and responsible for resistance of gram-negative bacteria to organic solvents. Reverse transcription polymerase chain reaction (RT-PCR) revealed the RNA transcripts of this gene in the cells grown on either DCM or methanol. The mobilizable suicide vector pK18mob was used to obtain a knockout mutant with the METDI2644 gene inactivated by insertion of the gentamycin cassette. The mutant pregrown on methanol exhibited lower growth rate on DCM than the wild-type strain DM4. The difference was not alleviated by addition of sodium molybdate. Our results suggest that the METDI2644 gene product plays a role in cell adaptation to DCM degradation.

  12. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.

    Science.gov (United States)

    Gross, Barbara; Pawlak, Michal; Lefebvre, Philippe; Staels, Bart

    2017-01-01

    Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), which are all related to inappropriate ectopic lipid deposition. Identification of the pathogenic molecular mechanisms and effective therapeutic approaches are highly needed. The peroxisome proliferator-activated receptors (PPARs) modulate several biological processes that are perturbed in obesity, including inflammation, lipid and glucose metabolism and overall energy homeostasis. Here, we review how PPARs regulate the functions of adipose tissues, such as adipogenesis, lipid storage and adaptive thermogenesis, under healthy and pathological conditions. We also discuss the clinical use and mechanism of PPAR agonists in the treatment of obesity comorbidities such as dyslipidaemia, T2DM and NAFLD. First generation PPAR agonists, primarily those acting on PPARγ, are associated with adverse effects that outweigh their clinical benefits, which led to the discontinuation of their development. An improved understanding of the physiological roles of PPARs might, therefore, enable the development of safe, new PPAR agonists with improved therapeutic potential.

  13. Feed intake and production parameters of lactating crossbred cows fed maize-based diets of stover, silage or quality protein silage.

    Science.gov (United States)

    Gebrehawariat, Efrem; Tamir, Berhan; Tegegne, Azage

    2010-12-01

    Thirty-six Boran × Friesian dairy cows (392 ± 12 kg; mean ± SD) in early parity were used in a randomised complete block design. Cows were blocked by parity into three blocks of 12 animals and offered normal maize (NM) stover (T1), NM silage (T2) or quality protein maize (QPM) silage (T3) basal diets supplemented with a similar concentrate mix. Feed intake, body weight and condition changes and milk yield and composition were assessed. The daily intake of DM, OM, NDF and ADF for cows fed the NM stover-based diet was higher (Psilage and QPM silage-based diets. However, the daily intake of DOM (9.3 kg) and ME (140.8 MJ) for cows on QPM silage-based diet was higher (Psilage-based diet (7.9 kg and 119.1 MJ). Body weight of cows was affected (P0.05) on body condition score, milk yield and milk composition. The digestible organic matter in the NM stover-based diet (724 g/kg DM) was lower (Psilage-based diet (762 g/kg DM). It was concluded that the performances of the cows on the NM silage and QPM silage diets were similar and were not superior to that of the NM stover-based diet.

  14. High blood pressure and diet

    Science.gov (United States)

    ... increase the potassium in your diet or use salt substitutes (which often contain potassium). People who have kidney ... consume. Alternative Names Hypertension - diet Images DASH diet Low sodium diet References American Heart Association Nutrition Committee; Lichtenstein ...

  15. [Nutritional genomics: toward a personalized diet].

    Science.gov (United States)

    Miggiano, G A D; De Sanctis, R

    2006-01-01

    Nutrigenomics is the application of high-throughput genomics tools to the study of diet-gene interactions in order to identify dietetic components having beneficial or detrimental health effects. Nutrition becomes indeed one of the environmental factors influencing gene expression. We can consider nutrigenomics as a multidisciplinary science that comes after the human genome characterization and that put the genomic techniques besides the biochemical and epidemiological aspects, with the aim to understand the etiologic aspects of chronic diseases such as cancer, type 2 diabetes mellitus (T2DM), obesity, cardiovascular diseases (CVD), metabolic syndrome, etc. Nutrigenomics is linked to nutrigenetics, which studies the genetic basis of the different individual response to the same nutritional stimulus. This phenomenon arises from gene polymorphism. As a consequence genes are important in determining a function, but nutrition is able to modify the degree of gene expression. These are however theories only at an early stage, but a perspective in the change of dietetic intervention is emerging. A really personalized diet will be a diet considering the nutritional status, the nutritional needs based on age, body composition, work and physical activities, but also considering the genotype. The integration of all these information and in particular the ones arising from genomic, proteomic and metabolomic analyses will be useful to define the "nutritional phenotype".

  16. SY 10-2 THE ROLE OF SGLT2 INHIBITORS IN THE MANAGEMENT OF T2DM.

    Science.gov (United States)

    Jung, Chang Hee

    2016-09-01

    Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder and is a major global public health problem with a rapidly increasing prevalence. Although a wide range of pharmacotherapy for glycemic control in T2DM is now available, management of T2DM remains complex and challenging. The kidneys contribute to glucose homeostasis primarily by the glucose reabsorption from the glomerular filtrate. The sodium-glucose co-transporter 2 (SGLT2) inhibitors, a new class of antidiabetes agents that inhibit glucose absorption from the kidney tubule independent of insulin, offer a unique opportunity to improve outcomes for patient with T2DM.In this session, I'd like to discuss several topics regarding SGLT2 inhibitors including their glucose lowering effects, recently issued adverse effects and long-term cardiovascular benefits from the perspectives of endocrinologist.

  17. Biohydrogen production from desugared molasses (DM) using thermophilic mixed cultures immobilized on heat treated anaerobic sludge granules

    DEFF Research Database (Denmark)

    Kongjan, Prawit; O-Thong, Sompong; Angelidaki, Irini

    2011-01-01

    Hydrogen production from desugared molasses (DM) was investigated in both batch and continuous reactors using thermophilic mixed cultures enriched from digested manure by load shock (loading with DM concentration of 50.1 g-sugar/L) to suppress methanogens. H2 gas, free of methane, was produced...... by Thermoanaerobacterium spp., which are key players in fermentative hydrogen production of DM under thermophilic conditions. Furthermore, the granules in the UASB reactor were also significantly containing Thermoanaerobacterium spp. and phylum Firmecutes (most Clotridium, Bacillus and Desulfobacterium....... The enriched hydrogen producing mixed culture achieved from the 16.7 g-sugars/L DM batch cultivation was immobilized on heat treated anaerobic sludge granules in an up-flow anaerobic sludge blanket (UASB) reactor. The UASB reactor, operated at a hydraulic retention time (HRT) of 24 h fed with 16.7 g...

  18. Feeding behavior of sheep fed diets with Elaeis guineensis palm kernel meal

    Directory of Open Access Journals (Sweden)

    Bianca Damasceno Pinho

    2016-09-01

    Full Text Available In order to evaluate the feeding behavior of sheep fed with diets containing different levels of palm kernel meal (PKM substituted for corn silage, a metabolic assay was performed on 20 ewes (5 treatments × 4 replicates over 25 d. The animals received corn silage diets with the addition of increasing levels of PKM (0, 15, 30, 45, and 60%. The following parameters were evaluated: dry matter (DM intake, neutral detergent fiber (NDF intake, feeding time, rumination time, idle time, number of merycism mastications per bolus, time spent ruminating each bolus, DM and NDF per bolus, number of ruminated boluses per day, feeding and rumination efficiency, total chewing time, and number of merycism mastications per day. The daily intake of both DM and NDF increased linearly (P < 0.05, and when sheep were fed diets of at least 43.18 and 39.15% PKM, respectively, the consumption values were significantly different than when sheep were fed diets with 0% PKM (P < 0.05. In contrast, feeding time declined linearly, and in response to diets with at least 28.05% PKM, the sheep exhibited significantly different feeding times from those of sheep fed 0% PKM, with a reduction of 0.0613 percentage points per 1% increase in PKM. Idle time, rumination time, and rumination time per bolus each exhibited quadratic responses (P < 0.05, and the minimum rumination time per bolus was 44.37 s with 35.19% PKM. A quadratic response was also observed for total chewing time and both measures of merycism mastications (P < 0.05. Therefore, we concluded that the inclusion of PKM in the diets of sheep improves some parameters of feeding behavior, and the use of PKM is recommended at DM percentages of up to 40%.

  19. The interaction of the antitoxin DM43 with a snake venom metalloproteinase analyzed by mass spectrometry and surface plasmon resonance

    DEFF Research Database (Denmark)

    Brand, Guilherme D; Salbo, Rune; Jørgensen, Thomas J D

    2012-01-01

    obtained after successive injections of DM43 in a concentration series were globally fitted to a simple bimolecular interaction, yielding the following kinetic rates for the DM43/jararhagin interaction: k(a) = 3.54 ± 0.03 × 10(4) M(-1) s(-1) and k(d) = 1.16 ± 0.07 × 10(-5) s(-1), resulting...

  20. Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.

    Science.gov (United States)

    Guandalini, L; Martini, E; Di Cesare Mannelli, L; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Ghelardini, C; Romanelli, M N

    2012-03-01

    A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.

  1. Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

    Science.gov (United States)

    Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella

    2015-04-15

    A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure-activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a.

  2. Hubungan Tingkat Keteraturan Berolahraga Terhadap Komplikasi Penyakit pada Pasien DM Tipe 2 di Poliklinik Endokrin RSUP DR. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Reza Ekatama Rajasa

    2016-08-01

    Full Text Available AbstrakAda banyak faktor yang mempengaruhi komplikasi pada pasien DM tipe 2, salah satunya adalah keteraturan berolahraga. Aktivitas fisik yang kurang akan  berisiko terjadinya hiperglikemia. Kondisi ini lambat laun akan menyebabkan kerusakan mikrovaskular dan makrovaskular. Olahraga yang teratur dapat membuat normal gula darah. Tujuan penelitian ini adalah meneliti lebih lanjut tentang hubungan keteraturan berolahraga terhadap komplikasi DM tipe 2. Penelitian ini dilakukan pada masyarakat yang berkunjung ke poliklinik RSUP Dr. M. Djamil Padang. Ini merupakan studi retrospektif dengan jumlah subjek 73 orang. Pengumpulan data responden dilakukan dengan wawancara dan rekam medis. Analisis statistik yang digunakan adalah uji chi-square.Hasil penelitian ini menunjukkan bahwa 65,8% responden menderita 3 atau lebih komplikasi (banyak, sedangkan 34,2% menderita kurang dari 3 komplikasi (sedikit. Kesimpulan studi ini adalah terdapat hubungan antara keteraturan berolahraga dengan komplikasi DM tipe 2.Kata kunci: keteraturan berolahraga, komplikasi DM tipe 2AbstractThere are many factors correlate to complications in  type 2 diabetes mellitus (DM patients, one of them is exercise regularity. Lack of physical activity can lead to the hiperglycemia condition. It  could be the cause of  micovascular and macrovascular injuries. Exercise regularity can lead blood glucose toward normal. The objective of this study was to investigate the correlation of exercise regularity to the type 2 DM complications.The research was conducted to the  people who visit polyclynic of M. Djamil Hospital. It is a retrospective study with 73 subjek. Data collection was performed through interviews and using medical records. The statistical analysis was performed chi-square test.The result of this research found that 65.8% of respondent had many complication ( three or more, whereas 34.2% of had less than three complications. Analysis by chi square test, concluded that there

  3. Sustained cardiac remodeling after a short-term very low calorie diet in type 2 diabetes mellitus patients.

    Science.gov (United States)

    Jonker, Jacqueline T; Snel, Marieke; Hammer, Sebastiaan; Jazet, Ingrid M; van der Meer, Rutger W; Pijl, Hanno; Meinders, A Edo; de Roos, Albert; Smit, Johannes W A; Romijn, Johannes A; Lamb, Hildo J

    2014-01-01

    A very low calorie diet (VLCD) results in cardiac remodeling and improved diastolic function. It is unknown how long these effects sustain after reintroduction of a regular diet. We aimed to assess the long-term effects of initial weight loss by VLCD on cardiac dimensions and function in type 2 diabetes mellitus (T2DM) patients. Fourteen insulin-dependent T2DM patients (mean ± SEM: age 53 ± 2 years; BMI 35 ± 1 kg/m(2)) were treated by a VLCD (450 kcal/day) during 16 weeks. Cardiac function and myocardial triglyceride (TG) content were measured by magnetic resonance imaging and spectroscopy at baseline, after a 16-week VLCD and after 14 months of follow-up on a regular diet. BMI decreased from 35 ± 1 to 28 ± 1 kg/m(2) after VLCD and increased again to 32 ± 1 kg/m(2) at 18 months (both P diet.

  4. Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus

    DEFF Research Database (Denmark)

    Sildorf, Stine Møller; Fredheim, Siri; Svensson, Jannet

    2012-01-01

    A 5-year and 10-month old boy was diagnosed with classical type 1 diabetes mellitus (T1DM) without celiac disease. He started on a gluten-free diet after 2–3 week without need of insulin treatment. At the initiation of gluten-free diet, HbA1c was 7.8% and was stabilised at 5.8%–6.0% without insulin...... therapy. Fasting blood glucose was maintained at 4.0–5.0 mmol/l. At 16 months after diagnosis the fasting blood glucose was 4.1 mmol/l and after 20 months he is still without daily insulin therapy. There was no alteration in glutamic acid decarboxylase positivity. The gluten-free diet was safe and without...... side effects. The authors propose that the gluten-free diet has prolonged remission in this patient with T1DM and that further trials are indicated....

  5. A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.

    Science.gov (United States)

    Yin, Liusong; Stern, Lawrence J

    2014-04-01

    HLA-DM (DM) functions as a peptide editor that mediates the exchange of peptides loaded onto MHCII molecules by accelerating peptide dissociation and association kinetics. The relative DM-susceptibility of peptides bound to MHCII molecules correlates with antigen presentation and immunodominance hierarchy, and measurement of DM-susceptibility has been a key effort in this field. Current assays of DM-susceptibility, based on differential peptide dissociation rates measured for individually labeled peptides over a long time base, are difficult and cumbersome. Here, we present a novel method to measure DM-susceptibility based on peptide binding competition assays performed in the presence and absence of DM, reported as a delta-IC(50) (change in 50% inhibition concentration) value. We simulated binding competition reactions of peptides with various intrinsic and DM-catalyzed kinetic parameters and found that under a wide range of conditions the delta-IC(50) value is highly correlated with DM-susceptibility as measured in off-rate assay. We confirmed experimentally that DM-susceptibility measured by delta-IC(50) is comparable to that measured by traditional off-rate assay for peptides with known DM-susceptibility hierarchy. The major advantage of this method is that it allows simple, fast and high throughput measurement of DM-susceptibility for a large set of unlabeled peptides in studies of the mechanism of DM action and for identification of CD4+ T cell epitopes.

  6. Diet induced thermogenesis

    Directory of Open Access Journals (Sweden)

    Westerterp KR

    2004-08-01

    Full Text Available Objective Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and characteristics of the diet. Methods Measuring conditions include nutritional status of the subject, physical activity and duration of the observation. Diet characteristics are energy content and macronutrient composition. Results Most studies measure diet-induced thermogenesis as the increase in energy expenditure above basal metabolic rate. Generally, the hierarchy in macronutrient oxidation in the postprandial state is reflected similarly in diet-induced thermogenesis, with the sequence alcohol, protein, carbohydrate, and fat. A mixed diet consumed at energy balance results in a diet induced energy expenditure of 5 to 15 % of daily energy expenditure. Values are higher at a relatively high protein and alcohol consumption and lower at a high fat consumption. Protein induced thermogenesis has an important effect on satiety. In conclusion, the main determinants of diet-induced thermogenesis are the energy content and the protein- and alcohol fraction of the diet. Protein plays a key role in body weight regulation through satiety related to diet-induced thermogenesis.

  7. Diet quality assessment indexes

    Directory of Open Access Journals (Sweden)

    Kênia Mara Baiocchi de Carvalho

    2014-10-01

    Full Text Available Various indices and scores based on admittedly healthy dietary patterns or food guides for the general population, or aiming at the prevention of diet-related diseases have been developed to assess diet quality. The four indices preferred by most studies are: the Diet Quality Index; the Healthy Eating Index; the Mediterranean Diet Score; and the Overall Nutritional Quality Index. Other instruments based on these indices have been developed and the words 'adapted', 'revised', or 'new version I, II or III' added to their names. Even validated indices usually find only modest associations between diet and risk of disease or death, raising questions about their limitations and the complexity associated with measuring the causal relationship between diet and health parameters. The objective of this review is to describe the main instruments used for assessing diet quality, and the applications and limitations related to their use and interpretation.

  8. Soybean oil and beef tallow in dry extruded diets for adult dogs.

    Science.gov (United States)

    Marx, Fábio Ritter; Trevizan, Luciano; Ahlstrøm, Øystein; Kessler, Alexandre de Mello

    2015-01-01

    The aim of the study was to determine the effects of two different fat sources (soybean oil (SO) and beef tallow (BT)) in dry extruded dog diets on the intake of food and metabolizable energy (ME), on faecal characteristics and apparent total tract digestibility (ATTD) of nutrients and energy. Ten adult dogs of different breeds were used in a Latin square design. Five experimental diets were designed from a basal diet. A Control diet was coated with 1% SO and four other diets were obtained by coating the basal diet with 6.5% and 13% of SO or BT. The Control, 6.5% and 13% coated diets contained approximately 8.5%, 15% and 20% fat, respectively. The dogs had similar dry matter (DM) intakes and, consequently, higher ME intakes with an increased fat content for both sources (p < 0.05). Fat digestibility was highest for Diet SO13% (p < 0.05). The ATTD of DM and organic matter was highest (p < 0.05) for Diets SO13% and BT13%. Fat coating improved the faecal score, especially for Diet BT13%. The dietary ratios of protein:fat:carbohydrate [% of ME] were close to AAFCO's estimates. For SO a higher ATTD (99.1%) and ME content (38.88 MJ/kg) was estimated than for BT (ATTD 92.9% and 36.37 MJ ME/kg). Both SO and BT can comprise up to 13% of the diet. However, SO was more susceptible to leaking from the kibbles with the coating method applied.

  9. CTG repeats distribution and Alu insertion polymorphism at myotonic dystrophy (DM) gene in Amhara and Oromo populations of Ethiopia.

    Science.gov (United States)

    Gennarelli, M; Pavoni, M; Cruciani, F; De Stefano, G; Dallapiccola, B; Novelli, G

    1999-01-01

    Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disease, highly variable and multisystemic, which is caused by the expansion of a CTG repeat located in the 3' untranslated region of the DMPK gene. Normal alleles show a copy number of 5-37 repeats on normal chromosomes, amplified to 50-3000 copies on DM chromosomes. The trinucleotide repeat shows a trimodal allele distribution in the majority of the examined population. The first class includes alleles carrying (CTG)5, the second class, alleles in the range 7-18 repeats, and the third class, alleles (CTG) > or =19. The frequency of this third class is directly related to the prevalence of DM in different populations, suggesting that normal large-sized alleles predispose toward DM. We studied CTG repeat allele distribution and Alu insertion and/or deletion polymorphism at the myotonic dystrophy locus in two major Ethiopian populations, the Amhara and Oromo. CTG allele distribution and haplotype analysis on a total of 224 normal chromosomes showed significant differences between the two ethnic groups. These differences have a bearing on the out-of-Africa hypothesis for the origin of the DM mutation. In addition, (CTG) > or =19 were exclusively detected in the Amhara population, confirming the predisposing role of these alleles compared with the DM expansion-mutation.

  10. Development of a genomic DNA reference material panel for myotonic dystrophy type 1 (DM1) genetic testing.

    Science.gov (United States)

    Kalman, Lisa; Tarleton, Jack; Hitch, Monica; Hegde, Madhuri; Hjelm, Nick; Berry-Kravis, Elizabeth; Zhou, Lili; Hilbert, James E; Luebbe, Elizabeth A; Moxley, Richard T; Toji, Lorraine

    2013-07-01

    Myotonic dystrophy type 1 (DM1) is caused by expansion of a CTG triplet repeat in the 3' untranslated region of the DMPK gene that encodes a serine-threonine kinase. Patients with larger repeats tend to have a more severe phenotype. Clinical laboratories require reference and quality control materials for DM1 diagnostic and carrier genetic testing. Well-characterized reference materials are not available. To address this need, the Centers for Disease Control and Prevention-based Genetic Testing Reference Material Coordination Program, in collaboration with members of the genetic testing community, the National Registry of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Patients and Family Members, and the Coriell Cell Repositories, has established and characterized cell lines from patients with DM1 to create a reference material panel. The CTG repeats in genomic DNA samples from 10 DM1 cell lines were characterized in three clinical genetic testing laboratories using PCR and Southern blot analysis. DMPK alleles in the samples cover four of five DM1 clinical categories: normal (5 to 34 repeats), mild (50 to 100 repeats), classical (101 to 1000 repeats), and congenital (>1000 repeats). We did not identify or establish Coriell cell lines in the premutation range (35 to 49 repeats). These samples are publicly available for quality control, proficiency testing, test development, and research and should help improve the accuracy of DM1 testing.

  11. Characterization of a noncytotoxic bacteriocin from probiotic Lactobacillus plantarum DM5 with potential as a food preservative.

    Science.gov (United States)

    Das, Deeplina; Goyal, Arun

    2014-10-01

    The aim of this work was to purify and characterize the bacteriocin produced by probiotic Lactobacillus plantarum DM5 in order to evaluate its potential as nutraceuticals. Lb. plantarum DM5 exhibited in vitro probiotic properties such as high resistance to gastric juice and bile salt, adherence to human adenocarcinoma (HT-29) cells, bile salt hydrolase and cholesterol assimilation activity. Moreover, Lb. plantarum DM5 showed bacteriocin activity against several major food borne pathogens. Zymogram analysis of purified bacteriocin (plantaricin DM5) showed a molecular size of ∼15.2 kDa. Plantaricin DM5 was sensitive to proteolytic enzymes but stable in the pH range of 2.0-10.0, and it was heat resistant (121 °C for 15 min) and remained active upon treatment with surfactants and detergents. Cytotoxicity analysis of plantaricin DM5 on human embryonic kidney 293 (HEK 293) and human cervical cancer (HeLa) cell lines revealed its nontoxic and biocompatible nature. To the best of our knowledge, this is the first study on the isolated strain expressing probiotic properties and broad antimicrobial activity without any cytotoxic effect on mammalian cells from indigenous fermented beverage Marcha from India, and thus contributes to the food industry as a novel bio-preservant.

  12. Inhibition of HLA-DM mediated MHC class II peptide loading by HLA-DO promotes self tolerance

    Directory of Open Access Journals (Sweden)

    Lisa K. Denzin

    2013-12-01

    Full Text Available Major histocompatibility class II (MHCII molecules are loaded with peptides derived from foreign and self-proteins within the endosomes and lysosomes of antigen presenting cells (APCs. This process is mediated by interaction of MHCII with the conserved, nonpolymorphic MHCII-like molecule HLA-DM (DM. DM activity is directly opposed by HLA-DO (DO, another conserved, non-polymorphic MHCII like molecule. DO is an MHCII substrate mimic. Binding of DO to DM prevents MHCII from binding to DM, thereby inhibiting peptide loading. Inhibition of DM function enables low stability MHC complexes to survive and populate the surface of APCS. As a consequence, DO promotes the display of a broader pool of low abundance self-peptides. Broadening the peptide repertoire theoretically reduces the likelihood of inadvertently acquiring a density of self-ligands that is sufficient to activate self-reactive T cells. One function of DO, therefore, is to promote T cell tolerance by shaping the visible image of self. Recent data also shows that DO influences the adaptive immune response by controlling B cell entry into the germinal center reaction. This review explores the data supporting these concepts.

  13. Bioinformatics Analysis of Mitochondrial Transcription Termination Factor DmTTF Protein in Drosophila melanogaster%黑腹果蝇线粒体转录终止因子DmTTF蛋白的生物信息学分析

    Institute of Scientific and Technical Information of China (English)

    熊伟; 张晓娟; 左绍远; 张海洋; 冯慕华

    2015-01-01

    Objective: To analyze the structure and function of mitochondrial transcription termination factor DmTTF protein in Drosophila melanogaster based on bioinformatics method. Methods:Based on the amino acid sequence of mitochondrial transcription termination factor DmTTF protein in D. melanogaster from FlyBase database, the protein physicochemical property, hydrophilicity/hydrophobicity, subcellular localization, secondary protein structure, protein domain, protein tertiary structure, protein-protein interaction, as well as the protein evolution relationship of different species were analyzed by using different bioinformatics software. Results: The mitochondrial transcription termination factor DmTTF protein consists of 410 amino acids, the estimated theoretical molecular weight and is oelectric point were 48.3 kDa and 9.62 respectively, which belong to the MTERF protein superfamily without transmembrane region, and it is a hydrophilic protein. The main composition of the DmTTF protein secondary structure were α-helix and random coil, showed similar result with protein tertiary structure whose spatial structure and the coverage of template protein 3mvb.1.A was 74.0%. Proteins that interact with DmTTF were mitochondrial transcription factors or mitochondrial respiratory chain proteins. DmTTF protein in D. melanogaster and encoded homologous protein in Musca demestica and Anopheles darlingi showed highly homology. Conclusion: DmTTF protein in D. melanogaster contained the typical structure of mitochondrial transcription termination factor protein family, which might involve in the transcription regulation of mitochondrial gene of D. melanogaster.%目的:基于生物信息学方法分析黑腹果蝇线粒体转录终止因子DmTTF蛋白的结构和功能.方法:检索FlyBase数据库中黑腹果蝇线粒体转录终止因子DmTTF蛋白的氨基酸序列,利用不同生物信息学软件对该蛋白质的理化性质、亲水性/疏水性、亚细胞定位、二级结

  14. Importance of low carbohydrate diets in diabetes management

    Directory of Open Access Journals (Sweden)

    Hall RM

    2016-03-01

    Full Text Available Rosemary M Hall, Amber Parry Strong, Jeremy D KrebsCentre for Endocrine, Diabetes and Obesity Research, Capital and Coast District Health Board, Wellington, New Zealand Abstract: Dietary strategies are fundamental in the management of diabetes. Historically, strict dietary control with a low carbohydrate diet was the only treatment option. With increasingly effective medications, the importance of dietary change decreased. Recommendations focused on reducing dietary fat to prevent atherosclerotic disease, with decreasing emphasis on the amount and quality of carbohydrate. As the prevalence of obesity and diabetes escalates, attention has returned to the macronutrient composition of the diet. Very low carbohydrate diets (VLCD's have demonstrated effective initial weight loss and improvement in glycemic control, but difficult long-term acceptability and worsening lipid profile. Modifications to the very low carbohydrate (VLC have included limiting saturated fat and increasing carbohydrate (CHO and protein. Reducing saturated fat appears pivotal in reducing low-density lipoprotein (LDL cholesterol and may mitigate adverse effects of traditional VLCD's. Increased dietary protein enhances satiety, reduces energy intake, and improves glycemic homeostasis, but without sustained improvements in glycemic control or cardiovascular risk over and above the effect of weight loss. Additionally, recent studies in type 1 diabetes mellitus suggest promising benefits to diabetes control with low carbohydrate diets, without concerning effects on ketosis or hypoglycemia. Dietary patterns may highlight pertinent associations. For example, Mediterranean-style and paleolithic-type diets, low in fat and carbohydrate, are associated with reduced body weight and improved glycemic and cardiovascular outcomes in type 2 diabetes mellitus (T2DM. A feature of these dietary patterns is low refined CHO and sugar and higher fiber, and it is possible that increasing sugar

  15. Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice.

    Science.gov (United States)

    Rhee, Ki-Jong; Lee, Chang Gun; Kim, Sung Woo; Gim, Dong-Hyeon; Kim, Hyun-Cheol; Jung, Bae Dong

    2015-01-01

    Diabetes mellitus (DM) is caused by either destruction of pancreatic β-cells (type 1 DM) or unresponsiveness to insulin (type 2 DM). Conventional therapies for diabetes mellitus have been developed but still needs improvement. Many diabetic patients have complemented conventional therapy with alternative methods including oral supplementation of natural products. In this study, we assessed whether Ginkgo biloba extract (EGb) 761 could provide beneficial effects in the streptozotocin-induced type 1 DM and high-fat diet-induced type 2 DM murine model system. For the type 1 DM model, streptozotocin-induced mice were orally administered EGb 761 for 10 days prior to streptozotocin injection and then again administered EGb 761 for an additional 10 days. Streptozotocin-treated mice administered EGb 761 exhibited lower blood triglyceride levels, lower blood glucose levels and higher blood insulin levels compared to streptozotocin-treated mice. Furthermore, liver LPL and liver PPAR-α were increased whereas IL-1β and TNF-α were decreased in streptozotocin-injected mice treated with EGb 761 compared to mice injected with streptozotocin alone. For the type 2 DM model, mice were given high-fat diet for 60 days and then orally administered EGb 761 every other day for 80 days. We found that mice given a high-fat diet and EGb 761 showed decreased blood triglyceride levels, increased liver LPL, increased liver PPAR-α and decreased body weight compared to mice given high-fat diet alone. These results suggest that EGb 761 can exert protective effects in both type 1 and type 2 DM murine models.

  16. Background studies for a ton-scale argon dark matter detector (ArDM)

    CERN Document Server

    Kaufmann, L

    2006-01-01

    The ArDM project aims at operating a large noble liquid detector to search for direct evidence of Weakly Interacting Massive Particles (WIMP) as Dark Matter in the universe. Background sources relevant to ton-scale liquid and gaseous argon detectors, such as neutrons from detector components, muon-induced neutrons and neutrons caused by radioactivity of rock, as well as the internal $^{39}Ar$ background, are studied with simulations. These background radiations are addressed with the design of an appropriate shielding as well as with different background rejection potentialities. Among them the project relies on event topology recognition, event localization, density ionization discrimination and pulse shape discrimination. Background rates, energy spectra, characteristics of the background-induced nuclear recoils in liquid argon, as well as the shielding performance and rejection performance of the detector are described.

  17. STT Doubles with Large DM - Part V: Aquila, Delphinus, Cygnus, Aquarius

    Science.gov (United States)

    Knapp, Wilfried; Nanson, John

    2016-07-01

    The results of visual double star observing sessions suggested a pattern for STT doubles with large DM of being harder to resolve than would be expected based on the WDS catalog data. It was felt this might be a problem with expectations on one hand, and on the other might be an indication of a need for new precise measurements, so we decided to take a closer look at a selected sample of STT doubles and do some research. We found that, as in the other constellations covered so far (Gem, Leo, UMa etc.), at least several of the selected objects in Aql, Del, Cyg and Aqr show parameters quite different from the current WDS data

  18. DM9000AE及其在嵌入式以太网中的应用

    Institute of Scientific and Technical Information of China (English)

    黄惠群; 吴景东

    2006-01-01

    介绍了一种以ARM微处理器LPC2106为核心的嵌入式以太网接口设计方法.对系统软硬件设计进行了介绍.硬件部分介绍了系统的硬件组成以及网络控制器DM9000AE的性能和工作原理.系统软件设计介绍了IwIP TCP/IP协议的移植以及应该注意的问题.在此软硬件基础上完成了一种轻型的,性价比高的嵌入式以太网接口卡的设计.

  19. WJD 5th Anniversary Special Issues(2): Type 2 diabetes Structured SMBG in early management of T2DM: Contributions from the St Carlos study

    Institute of Scientific and Technical Information of China (English)

    Teresa; Ruiz; Gracia; Nuria; García; de; la; Torre; Lobo; Alejandra; Durán; Rodríguez; Hervada; Alfonso; L; Calle; Pascual

    2014-01-01

    Diabetes mellitus type 2(T2DM)is a global pandemic that will affect 300 million people in the next decade.It has been shown that early and aggressive treatment of T2DM from the onset decreases complications,and the patient’s active role is necessary to achieve better glycemic control.In order to achieve glycemic control targets,an active attitude in patients is needed,and selfmonitoring of blood glucose(SMBG)plays a significant role.Nowadays,SMBG has become an important component of modern therapy for diabetes mellitus,and is even more useful if it is performed in a structured way.SMBG aids physicians and patients to achieve a specific level of glycemic control and to prevent hypoglycemia.In addition,SMBG empowers patients to achieve nutritional and physical activity goals,and helps physicians to optimize the different hypoglycemic therapies as demonstrated in the St Carlos study.This article describes the different ways of using this educational and therapeutic tool from the medical point of view as well as from the patient’s perspective.

  20. The design of red-blue 3D video fusion system based on DM642

    Science.gov (United States)

    Fu, Rongguo; Luo, Hao; Lv, Jin; Feng, Shu; Wei, Yifang; Zhang, Hao

    2016-10-01

    Aiming at the uncertainty of traditional 3D video capturing including camera focal lengths, distance and angle parameters between two cameras, a red-blue 3D video fusion system based on DM642 hardware processing platform is designed with the parallel optical axis. In view of the brightness reduction of traditional 3D video, the brightness enhancement algorithm based on human visual characteristics is proposed and the luminance component processing method based on YCbCr color space is also proposed. The BIOS real-time operating system is used to improve the real-time performance. The video processing circuit with the core of DM642 enhances the brightness of the images, then converts the video signals of YCbCr to RGB and extracts the R component from one camera, so does the other video and G, B component are extracted synchronously, outputs 3D fusion images finally. The real-time adjustments such as translation and scaling of the two color components are realized through the serial communication between the VC software and BIOS. The system with the method of adding red-blue components reduces the lost of the chrominance components and makes the picture color saturation reduce to more than 95% of the original. Enhancement algorithm after optimization to reduce the amount of data fusion in the processing of video is used to reduce the fusion time and watching effect is improved. Experimental results show that the system can capture images in near distance, output red-blue 3D video and presents the nice experiences to the audience wearing red-blue glasses.

  1. Retrogression of Nervous Fibers According to the Age of Patients with Diabetes Mellitus (DM).

    Science.gov (United States)

    Han, Dongwook

    2013-09-01

    [Purpose] This study was performed to discover the possible onset time of diabetic neuropathy by age of diabetic patients, and to provide the knowledge necessary for preventing or managing diabetic neuropathy. [Subjects] The subjects of this study were outpatients who visited D Hospital Department of Neurology with complaints of significant neuropathic symptoms including dullness, numbness and paraesthesia. [Methods] Stimulations of 5 Hz, 250 Hz and 2,000 Hz were generated with a Neurometer CPT (Neurotron Inc., Baltimore, MD, USA) and delivered selectively to C fibers, A-delta fibers and A-beta fibers. The intensity of the stimulations of 5 Hz, 250 Hz and 2,000 Hz was incrementally increased as much as 0.01 mA. [Result] The results of this experiment show that the period of retrogression of nervous fibers was different significantly according to the age of patients with diabetes mellitus. Especially, in the case of individuals in their 50's, Aβ, Aδ, and C fibers in both the right and left lower limbs significantly changed within a period of 2 months. In the case of individuals in their 60's, Aβ and C fibers of the right lower limb meaningfully changed 2 months after the onset of the disease, and Aβ, Aδ, and C fibers of the left lower limb also significantly changed within a period of 2 months. [Conclusion] We discovered that patients suffering from DM especially in their 50's or 60's should be thoroughly followed for their condition, right from the onset of DM, in order to prevent the retrogression of nervous fibers.

  2. Ruminal fermentation of Nellore steers fed crude glycerine replacing starch vs. fibre-based energy ingredient in low or high concentrate diets

    Directory of Open Access Journals (Sweden)

    Josiane Fonseca Lage

    2017-02-01

    Full Text Available Twelve ruminally cannulated steers (401.0 ± 41.5 kg and 24 mo were used in a replicated arrangement truncated Latin Square with six animals in six treatments and four periods to evaluate the effect of crude glycerine (CG; 80.3% of glycerol with starch or fiber-based energy ingredients in the concentrate on DMI, DM (DMD and NDF digestibility (NDFD and ruminal parameters. Experimental periods were 19 days (14 days for adaptation and 5 days to sampling. Diets were: CO - without CG and corn as ingredient of concentrate; CGC - inclusion of CG (10% of DM with corn in the concentrate; and CGSH - inclusion of CG (10% of DM with soybean hulls (SH in the concentrate. All three diets were offered at low (LC or high (HC concentrate level, CL (40 or 60%. Animals fed LC or HC diets had similar DMI, DMD and NDFD. Animals fed diets with CG associated with corn or SH had higher propionate concentrations and lower A:P ratio. Diets with HC increase the propionate but do not affect the NDFD. CG (10% of DM can be used to replace corn or SH in diets with 40 or 60% of concentrate, without affect NDFD.

  3. Feed intake and production parameters of lactating crossbred cows fed maize-based diets of stover, silage or quality protein silage

    Science.gov (United States)

    Gebrehawariat, Efrem; Tegegne, Azage

    2010-01-01

    Thirty-six Boran × Friesian dairy cows (392 ± 12 kg; mean ± SD) in early parity were used in a randomised complete block design. Cows were blocked by parity into three blocks of 12 animals and offered normal maize (NM) stover (T1), NM silage (T2) or quality protein maize (QPM) silage (T3) basal diets supplemented with a similar concentrate mix. Feed intake, body weight and condition changes and milk yield and composition were assessed. The daily intake of DM, OM, NDF and ADF for cows fed the NM stover-based diet was higher (P  0.05) on body condition score, milk yield and milk composition. The digestible organic matter in the NM stover-based diet (724 g/kg DM) was lower (P < 0.05) than that in the NM (770 g/kg DM) and QPM silage-based diet (762 g/kg DM). It was concluded that the performances of the cows on the NM silage and QPM silage diets were similar and were not superior to that of the NM stover-based diet. PMID:20577806

  4. The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes

    DEFF Research Database (Denmark)

    Hansen, Merethe; Lund, Michael Taulo; Jørgensen, Anne Line Kjærholm

    2016-01-01

    AIMS: The impact of diet-induced weight loss and weight loss due to RYGB in patients with (T2DM, N = 16) and without (OB, N = 27) type 2 diabetes was studied. METHODS: At inclusion (A), after diet-induced weight loss (B), 4 months post-surgery (C) and 18 months post-surgery (D) body composition......, and approximately one-third of the total improvement in GIR in T2DM was observed after the diet-induced weight loss of only ~6 kg (B). Insulin clearance, visceral fat and fasting plasma insulin also improved significantly after the diet (P ... not change significantly, but IMTG decreased significantly consistent with significant increases in GIR. Metabolic flexibility and hepatic insulin sensitivity improved after RYGB. CONCLUSIONS: Metabolic improvements of RYGB are present already after the diet-induced weight loss prior to surgery. GLUT4...

  5. 健康教育对胃癌患者掌握饮食相关知识的效果分析%Effect of health education on the knowledge of diet in patients with gastric cance

    Institute of Scientific and Technical Information of China (English)

    王月红; 徐军霞

    2015-01-01

    目的:观察饮食指导及营养知识健康教育在胃癌患者中的效果。方法:采用自行设计的调查表对90例胃癌患者进行饮食行为及营养知识调查,根据结果采取相应的健康教育,出院前再次发放调查表,比较健康教育前后的差异性。结果胃癌患者日常饮食结构不合理,基本营养知识欠缺。教育前后各项知识比较,差异有统计学意义(P<0.01)。结论:胃癌患者饮食结构不合理。责任护士应加强基本营养知识宣教,尊重患者禁食中医所说“发物”的同时,遵循同类食物互换原则,指导其食用经济实惠的非发物类食物,使饮食结构达到均衡,以降低因忌口引起的营养不良发生率。%Objective:To observe the effect of dietary guidance and nutrition knowledge on health education in patients with gastric cancer.Methods:dietary behaviors and nutritional knowledge of 90 cases of patients with gastric cancer were investigated by a self-designed questionnaire.Corresponding health education was given accordingly and questionnaires were issued before being discharged, and the differences were compared before and after education. Results:the daily dietary structure of gastric cancer patients is unreasonable, the basic nutritional knowledge is deficient. The comparison of the education before and after knowledge of P<0.01, has a statistical difference. Conclusion:the dietary structure of gastric cancer patients is not reasonable. Nurses should strengthen basic nutrition knowledge education, respect the patients fasting the so-called stimulating food according to traditional Chinese medicine, follow similar food exchange principle, eat non volatiles food, and abide by diet structure equilibrium, thereby reducing the incidence of malnutrition due to unreasonable diet.

  6. Ma-Pi 2 macrobiotic diet and type 2 diabetes mellitus: pooled analysis of short-term intervention studies.

    Science.gov (United States)

    Porrata-Maury, C; Hernández-Triana, M; Ruiz-Álvarez, V; Díaz-Sánchez, M E; Fallucca, F; Bin, W; Baba-Abubakari, B; Pianesi, M

    2014-03-01

    The macrobiotic, Ma-Pi 2 diet (12% protein, 18% fat and 70% carbohydrate), has shown benefit in adults with type 2 diabetes mellitus (T2DM). This pooled analysis aims to confirm results from four, 21-day intervention studies with the Ma-Pi 2 diet, carried out in Cuba, China, Ghana and Italy. Baseline and end of study biochemical, body composition and blood pressure data, were compared using multivariate statistical methods and assessment of the Cohen effect size (d). Results showed that all measured indicators demonstrated significant changes (p diet was Italy (1.96), China (1.79), Cuba (1.38) and Ghana (0.98). The magnitude of the individual effect on each variable by country, and the global effect by country, was independent of the sample size (p > 0.05). Similarly, glycemia and glycemic profiles in all four studies were independent of the sample size (p = 0.237). The Ma-Pi diet 2 significantly reduced glycemia, serum lipids, uremia and cardiovascular risk in adults with T2DM. These results suggest that the Ma-Pi 2 diet could be a valid alternative treatment for patients with T2DM and point to the need for further clinical studies. Mechanisms related to its benefits as a functional diet are discussed.

  7. Reduced energy density of close-up diets decrease ruminal pH and increase concentration of volatile fatty acids postpartum in Holstein cows.

    Science.gov (United States)

    Huang, Wenming; Tian, Yujia; Li, Shengli; Wu, Zhaohai; Cao, Zhijun

    2017-06-27

    The objective of this study was to determine the effect of reduced energy density of close-up diets on ruminal fermentation parameters in transition cows. Fourteen Holstein dry cows were blocked and assigned randomly to three groups fed a high energy density diet (HD, 1.62 Mcal of net energy for lactation (NEL )/kg dry matter (DM)), or a middle energy density diet (MD, 1.47 Mcal NEL /kg DM), or a low energy density diet (LD, 1.30 Mcal NEL /kg DM) prepartum, and were fed the same diet postpartum. The reduced energy density diets decreased the average dry matter intake (DMI) prepartum and tended to increase the DMI postpartum. The ruminal pH of the LD group was significantly higher prepartum and lower during the first week of lactation compared with the other two groups. The reduced energy density diet depressed the average ruminal concentration of propionate and butyrate prepartum, and increased the average concentration of total volatile fatty acids (VFA) postpartum. The LD group had higher populations of Butyrivibrio fibrisolvens and Ruminococcus flavefaciens relative to HD and MD groups on 7 days in milk. In conclusion, the cows fed reduced energy density diet prepartum had higher VFA concentration, but were more susceptible to subacute ruminal acidosis postpartum. © 2017 Japanese Society of Animal Science.

  8. Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.

    Science.gov (United States)

    Scian, Michele; Le Trong, Isolde; Mazari, Aslam M A; Mannervik, Bengt; Atkins, William M; Stenkamp, Ronald E

    2015-10-01

    Cytosolic glutathione transferases (GSTs) comprise a large family of enzymes with canonical structures that diverge functionally and structurally among mammals, invertebrates and plants. Whereas mammalian GSTs have been characterized extensively with regard to their structure and function, invertebrate GSTs remain relatively unstudied. The invertebrate GSTs do, however, represent potentially important drug targets for infectious diseases and agricultural applications. In addition, it is essential to fully understand the structure and function of invertebrate GSTs, which play important roles in basic biological processes. Invertebrates harbor delta- and epsilon-class GSTs, which are not found in other organisms. Drosophila melanogaster GSTs (DmGSTs) are likely to contribute to detoxication or antioxidative stress during development, but they have not been fully characterized. Here, the structures of two epsilon-class GSTs from Drosophila, DmGSTE6 and DmGSTE7, are reported at 2.1 and 1.5 Å resolution, respectively, and are compared with other GSTs to identify structural features that might correlate with their biological functions. The structures of DmGSTE6 and DmGSTE7 are remarkably similar; the structures do not reveal obvious sources of the minor functional differences that have been observed. The main structural difference between the epsilon- and delta-class GSTs is the longer helix (A8) at the C-termini of the epsilon-class enzymes.

  9. Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.

    Science.gov (United States)

    Rinkevich, Frank D; Du, Yuzhe; Tolinski, Josh; Ueda, Atsushi; Wu, Chun-Fang; Zhorov, Boris S; Dong, Ke

    2015-03-01

    Voltage-gated sodium channels (Nav channels) are critical for electrical signaling in the nervous system and are the primary targets of the insecticides DDT and pyrethroids. In Drosophila melanogaster, besides the canonical Nav channel, Para (also called DmNav), there is a sodium channel-like cation channel called DSC1 (Drosophila sodium channel 1). Temperature-sensitive paralytic mutations in DmNav (para(ts)) confer resistance to DDT and pyrethroids, whereas DSC1 knockout flies exhibit enhanced sensitivity to pyrethroids. To further define the roles and interaction of DmNav and DSC1 channels in DDT and pyrethroid neurotoxicology, we generated a DmNav/DSC1 double mutant line by introducing a para(ts1) allele (carrying the I265N mutation) into a DSC1 knockout line. We confirmed that the I265N mutation reduced the sensitivity to two pyrethroids, permethrin and deltamethrin of a DmNav variant expressed in Xenopus oocytes. Computer modeling predicts that the I265N mutation confers pyrethroid resistance by allosterically altering the second pyrethroid receptor site on the DmNav channel. Furthermore, we found that I265N-mediated pyrethroid resistance in para(ts1) mutant flies was almost completely abolished in para(ts1);DSC1(-/-) double mutant flies. Unexpectedly, however, the DSC1 knockout flies were less sensitive to DDT, compared to the control flies (w(1118A)), and the para(ts1);DSC1(-/-) double mutant flies were even more resistant to DDT compared to the DSC1 knockout or para(ts1) mutant. Our findings revealed distinct roles of the DmNav and DSC1 channels in the neurotoxicology of DDT vs. pyrethroids and implicate the exciting possibility of using DSC1 channel blockers or modifiers in the management of pyrethroid resistance.

  10. Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

    Energy Technology Data Exchange (ETDEWEB)

    Poon, Kirsten Achilles, E-mail: achilles.kirsten@gene.com [Genentech, Inc., South San Francisco, CA (United States); Flagella, Kelly; Beyer, Joseph [Genentech, Inc., South San Francisco, CA (United States); Tibbitts, Jay [UCB, Brussels (Belgium); Kaur, Surinder; Saad, Ola; Yi, Joo-Hee; Girish, Sandhya; Dybdal, Noel; Reynolds, Theresa [Genentech, Inc., South San Francisco, CA (United States)

    2013-12-01

    Trastuzumab emtansine (T-DM1) is the first antibody-drug conjugate (ADC) approved for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. The therapeutic premise of ADCs is based on the hypothesis that targeted delivery of potent cytotoxic drugs to tumors will provide better tolerability and efficacy compared with non-targeted delivery, where poor tolerability can limit efficacious doses. Here, we present results from preclinical studies characterizing the toxicity profile of T-DM1, including limited assessment of unconjugated DM1. T-DM1 binds primate ErbB2 and human HER2 but not the rodent homolog c-neu. Therefore, antigen-dependent and non-antigen-dependent toxicity was evaluated in monkeys and rats, respectively, in both single- and repeat-dose studies; toxicity of DM1 was assessed in rats only. T-DM1 was well tolerated at doses up to 40 mg/kg (∼ 4400 μg DM1/m{sup 2}) and 30 mg/kg (∼ 6000 μg DM1/m{sup 2}) in rats and monkeys, respectively. In contrast, DM1 was only tolerated up to 0.2 mg/kg (1600 μg DM1/m{sup 2}). This suggests that at least two-fold higher doses of the cytotoxic agent are tolerated in T-DM1, supporting the premise of ADCs to improve the therapeutic index. In addition, T-DM1 and DM1 safety profiles were similar and consistent with the mechanism of action of DM1 (i.e., microtubule disruption). Findings included hepatic, bone marrow/hematologic (primarily platelet), lymphoid organ, and neuronal toxicities, and increased numbers of cells of epithelial and phagocytic origin in metaphase arrest. These adverse effects did not worsen with chronic dosing in monkeys and are consistent with those reported in T-DM1-treated patients to date. - Highlights: • T-DM1 was well tolerated in preclinical studies in rats and cynomolgus monkeys. • T-DM1 is associated with bone marrow/hematologic, hepatic, and neuronal toxicities. • T-DM1 toxicities are related to DM1 mechanisms of action and pharmacologic

  11. Insulin resistance in obese patients with type 2 diabetes mellitus : effects of a very low calorie diet

    NARCIS (Netherlands)

    Jazet, Ingrid Maria

    2006-01-01

    Insulin resistance is of major pathogenic importance in obese DM2 and this can be improved by weight loss. Very low calorie diets (VLCDs) are often used for this purpose. This thesis focused on the safety and tolerability of a VLCD and on the short-term and long-term effects of a VLCD on glucose and

  12. Insulin resistance in obese patients with type 2 diabetes mellitus : effects of a very low calorie diet

    NARCIS (Netherlands)

    Jazet, Ingrid Maria

    2006-01-01

    Insulin resistance is of major pathogenic importance in obese DM2 and this can be improved by weight loss. Very low calorie diets (VLCDs) are often used for this purpose. This thesis focused on the safety and tolerability of a VLCD and on the short-term and long-term effects of a VLCD on glucose and

  13. Models to quantify excretion of dry matter, nitrogen, phosphorus and carbon in growing pigs fed regional diets

    DEFF Research Database (Denmark)

    Jørgensen, Henry; Poulsen, Hanne Damgaard; Prapaspongsa, Trakarn

    2013-01-01

    used in a digestibility and balance experiment. Excretion of dry matter (DM), nitrogen (N), phosphorus (P) and carbon (C) of the experimental diets were determined. Due to the highest dietary fibre content, VN had the lowest digestibility of N, P and C (73, 49, and 73%, respectively) compared...

  14. Association of diet and lifestyle with glycated haemoglobin in type 1 diabetes participants in the EURODIAB prospective complications study

    NARCIS (Netherlands)

    Balk, S.N.; Schoenaker, D.A.J.M.; Mishra, G.D.; Toeller, M.; Chaturvedi, N.; Fuller, J.H.; Soedamah-Muthu, S.S.

    2016-01-01

    Background/Objectives: Diet and lifestyle advice for type 1 diabetes (T1DM) patients is based on little evidence and putative effects on glycaemic control. Therefore, we investigated the longitudinal relation between dietary and lifestyle variables and HbA1c levels in patients with type 1 diabetes.

  15. Meatless Diets in Female Athletes: A Red Flag.

    Science.gov (United States)

    Loosli, Alvin R.; Ruud, Jaime S.

    1998-01-01

    Physically active adolescent girls and young women who eliminate meat from their diets risk developing protein, iron, and zinc deficiencies. Meatless diets signal the possibility of amenorrhea and/or disordered eating, with the attendant risk of osteoporosis. Physicians must educate young women, parents, and coaches about the risks of meatless…

  16. Effect of Crude Protein Levels in Concentrate and Concentrate Levels in Diet on Fermentation

    Directory of Open Access Journals (Sweden)

    Dinh Van Dung

    2014-06-01

    Full Text Available The effect of concentrate mixtures with crude protein (CP levels 10%, 13%, 16%, and 19% and diets with roughage to concentrate ratios 80:20, 60:40, 40:60, and 20:80 (w/w were determined on dry matter (DM and organic matter (OM digestibility, and fermentation metabolites using an in vitro fermentation technique. In vitro fermented attributes were measured after 4, 24, and 48 h of incubation respectively. The digestibility of DM and OM, and total volatile fatty acid (VFA increased whereas pH decreased with the increased amount of concentrate in the diet (p<0.001, however CP levels of concentrate did not have any influence on these attributes. Gas production reduced with increased CP levels, while it increased with increasing concentrate levels. Ammonia nitrogen (NH3-N concentration and microbial CP production increased significantly (p<0.05 by increasing CP levels and with increasing concentrate levels in diet as well, however, no significant difference was found between 16% and 19% CP levels. Therefore, 16% CP in concentrate and increasing proportion of concentrate up to 80% in diet all had improved digestibility of DM and organic matter, and higher microbial protein production, with improved fermentation characteristics.

  17. Residual frying oil in the diets of sheep: intake, digestibility, nitrogen balance and ruminal parameters

    Directory of Open Access Journals (Sweden)

    Eduardo Lucas Terra Peixoto

    2017-01-01

    Full Text Available Objective The objective of this study was to evaluate the intake and nutrient digestibility, nitrogen balance and ruminal ammonia nitrogen in lambs of diets containing different levels of residual frying oil. Methods Levels of 0, 20, 40, 60, and 80 g/kg dry matter (DM base of residual frying oil in the diets of lambs were evaluated. Five castrated lambs with initial body weights of 36.8±3.3 kg, distributed in a Latin square (5×5 design, were used. Results There was a decreasing linear effect on the intake of DM, organic matter (OM, crude protein (CP, neutral detergent fiber (NDF, total carbohydrates (TCH, and nonfibrous carbohydrates (NFC. There was an increased linear intake of ether extract (EE. The apparent digestibility of DM, OM, CP, NDF, TCH, and NFC, as well as urine nitrogen excretion, nitrogen balance and ruminal parameters, were not influenced by different levels of residual frying oil in the diet. EE digestibility presented a crescent linear effect. Conclusion It can be concluded that the addition of residual frying oil to the diets of sheep can affect nutrient intake without affecting the digestibility of most nutrients (with the exception of EE, nitrogen balance and ruminal ammonia nitrogen concentration.

  18. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...... are only ameliorated to a minor degree by a healthy diet....

  19. Potential impact of Paracentrotus lividus extract on diabetic rat models induced by high fat diet/streptozotocin

    Directory of Open Access Journals (Sweden)

    Amel M. Soliman

    2016-10-01

    Full Text Available Antioxidant therapy has been thought to be effectual for the prevention and treatment of various diseases including diabetes. Therefore, the present study was designed to investigate the potency of Paracentrotus lividus extract (PLE for alleviating the complications that resulted after induction of the diabetic rat models (T1DM and T2DM using high fat diet (HFD/streptozotocin (STZ. Thirty six male Wistar albino rats were assigned into normal control, T1DM and T2DM untreated, and PLE treated diabetic rat groups. Induction of T1DM was performed by streptozotocin injection (60 mg/kg of dissolved in sodium citrate buffer, 0.1 mol/L, i.p. T2DM induction through 4 weeks of high fat diet (HFD intervention was followed by a single low dosage of STZ (30 mg/kg dissolved in 0.1 mol/L citrate buffer at pH 4.5, i.p. Both diabetic rat models showed a significant increase in serum; levels of fasting glucose, total protein, bilirubin, activities of arginase, transaminases (AST and ALT, alkaline phosphatase (ALP, γ glutamyl transferase (GGT, lipid profile parameters, and liver malondialdehyde (MDA. However, T1DM and T2DM rats have decreased levels of serum insulin, and liver glucose 6 phosphate dehydrogenase (G6PD, glutathione reduced (GSH, nitric oxide (NO, and antioxidant enzymes. Furthermore, the present study showed the hypoglycemic, hypolipidemic, and antioxidant potency of the PLE as confirmed by its ability for ameliorating most of the alterations caused in the studied parameters of diabetic rats. In conclusion, PLE may be useful as therapy against oxidative stress and liver damage in both types of diabetes mellitus and is therefore recommended for further studies.

  20. New Approaches to Planning Diabetic Diets Workshop.

    Science.gov (United States)

    Kimmel, Georgia

    Instructional materials are provided for a workshop to enable participants to educate patients and food service staff regarding diabetic diets, incorporating current therapeutic recommendations and allowing variation and flexibility. Representative topics are facts about diabetes mellitus, high risk groups, symptoms, treatment and goals of diet…

  1. New Nordic diet versus average Danish diet

    DEFF Research Database (Denmark)

    Khakimov, Bekzod; Poulsen, Sanne Kellebjerg; Savorani, Francesco

    2016-01-01

    A previous study has shown effects of the New Nordic Diet (NND) to stimulate weight loss and lower systolic and diastolic blood pressure in obese Danish women and men in a randomized, controlled dietary intervention study. This work demonstrates long-term metabolic effects of the NND as compared...... metabolites reflecting specific differences in the diets, especially intake of plant foods and seafood, and in energy metabolism related to ketone bodies and gluconeogenesis, formed the predominant metabolite pattern discriminating the intervention groups. Among NND subjects higher levels of vaccenic acid...... diets high in fish, vegetables, fruit, and wholegrain facilitated weight loss and improved insulin sensitivity by increasing ketosis and gluconeogenesis in the fasting state....

  2. Nutrient utilization and manure P excretion in growing pigs fed corn-barley-soybean based diets supplemented with microbial phytase.

    Science.gov (United States)

    Emiola, Adewale; Akinremi, Oluwole; Slominski, Bogdan; Nyachoti, C Martin

    2009-02-01

    The effect of high levels of microbial phytase supplementation in diets for growing pigs was studied in a 2-week performance and nutrient digestibility trial involving 28 growing pigs weighing 16.4 +/- 1.06 (mean +/- SD) kg. Seven corn-barley-soybean meal-based diets consisting of a positive control (PC) formulated to meet or exceed NRC nutrient requirements; a negative control (NC) with non-phytate P reduced by 0.1% unit from NRC requirement and fed without or with 500 or 1000 U/kg; a doubled negative control (DNC) with no added inorganic P and fed without or with 2000 or 4000 U/kg. Chromic oxide was added as an indigestible marker and all diets were fed as mash. Pigs fed the PC diet had a higher P digestibility compared with those fed the NC (P DNC (P DNC diet resulted in linear (P DNC diets. Apparent total tract digestibility of N, OM and DM were higher (P DNC diet, but not the NC diet (P DNC diet resulted in a linear increase (P DNC diets linearly decreased fecal P (P DNC diets (P < 0.05). The results of this study show that complete removal of inorganic P from growing pig diets coupled with phytase supplementation improves digestibility and retention of P and N, thus reducing manure P excretion without any negative effect on pig performance.

  3. EFFECT OF TARTARIC ACID ADDITION ON RUMEN FERMENTATION, METHANE PRODUCTION AND DIGESTIBILITY IN DIFFERENT DIETS CONTAINING WHEAT STRAW IN VITRO

    Directory of Open Access Journals (Sweden)

    S.K. SIROHI

    2012-05-01

    Full Text Available The aim of the current study was to evaluate the effect of tartaric acid addition in diets on in vitro methanogenesis and rumen fermentation. Different levels of tartaric acid (5, 10, and 15 ppm were tested for their effect on methanogenesis, rumen fermentation and digestibility in three wheat straw containing diets i.e. Low fiber diet (LFD, 40R:60C, medium fiber diet (MFD, 50R:50C and high fiber diet (HFD, 60R:40C. Evaluation of tartaric acid was carried out using in vitro gas production technique. Methane production and individual fatty acids were estimated by Gas Chromatography. Results of different levels of tartaric acid on in vitro methanogenesis indicated that the maximum methane reduction (22.60% in term of mM/gDM was observed in LFD at the supplementation dosage of 15 mM and a similar trend was seen, when methane was expressed in ml/gDM. Non-significant (P≤0.05 effect of tartaric acid addition on in vitro dry matter digestibility (IVDMD was observed in almost cases. Protozoal population decreased with increasing concentration of tartaric acid and maximum reduction (54.64% was in the MFD. Acetate to propionate ratio was decreased in tartaric acid supplemented diets which reflects increase in propionic acid production in comparison to control diet. Microbial biomass yield also increased due to the addition of tartaric acid in most of the diets.

  4. Pig performance increases with the addition of DL-methionine and L-lysine to ensiled cassava leaf protein diets.

    Science.gov (United States)

    Ly, Nguyen Thi Hoa; Ngoan, Le Duc; Verstegen, Martin Wilhelmus Antonius; Hendriks, Wouter Hendrikus

    2012-01-01

    Two studies were conducted to determine the impact of supplementation of diets containing ensiled cassava leaves as the main protein source with synthetic amino acids, DL-methionine alone or with L-lysine. In study 1, a total of 40 pigs in five units, all cross-breds between Large White and Mong Cai, with an average initial body weight of 20.5 kg were randomly assigned to four treatments consisting of a basal diet containing 45% of dry matter (DM) from ensiled cassava leaves (ECL) and ensiled cassava root supplemented with 0%, 0.05%, 0.1% and 0.15% DL-methionine (as DM). Results showed a significantly improved performance and protein gain by extra methionine. This reduced the feed cost by 2.6%, 7.2% and 7.5%, respectively. In study 2, there were three units and in each unit eight cross-bred (Large White × Mong Cai) pigs with an initial body weight of 20.1 kg were randomly assigned to the four treatments. The four diets were as follows: a basal diet containing 15% ECL (as DM) supplemented with different amounts of amino acids L-lysine and DL-methionine to the control diet. The results showed that diets with 15% of DM as ECL with supplementation of 0.2% lysine +0.1% DL-methionine and 0.1% lysine +0.05% DL-methionine at the 20-50 kg and above 50 kg, respectively, resulted in the best performance, protein gain and lowest costs for cross-bred (Large White × Mong Cai) pigs. Ensiled cassava leaves can be used as a protein supplement for feeding pigs provided the diets contain additional amounts of synthetic lysine and methionine.

  5. Diagnóstico molecular de la Distrofia Miotónica (DM en Costa Rica

    Directory of Open Access Journals (Sweden)

    Fernando Morales Montero

    2001-10-01

    Full Text Available La Distrofia Miotónica es una enfermedad multisistémica de herencia autosómica dominante. El defecto molecular es una expansión del trinucleótido CTG presente en la región 3' no codificante (3´UTR del gen DMPK, localizado en el cromosoma 19q13.3. El objetivo del estudio fue implementar el diagnóstico molecular de la Dm con el fin de contribuir a mejorar el manejo clínico de los pacientes afectados y a que el consejo genético sea más certero y preciso. El estudio se realizó en pacientes con diagnóstico mediante el uso de técnicas molecular, a saber, la hidridación de Southern y la PCR. Se obtuvo el diagnóstico molecular de 84 pacientes de 21 diferentes familias; en 34 se diagnosticó el defecto molecular. En 21 personas de familias donde se comprobó que segrega la mutación, el gen resultó normal. En 29 pacientes de ocho familias no se encontró la mutación. Se observó una correlación positiva entre la severidad de la enfermedad y el número de repeticiones CTG. Aquellos casos que resultaron negativos probablemente sean pacientes con mutaciones en otros genes, ya sea PROMM/DM2 u otras miotonias hereditarias. El diagnóstico molecular debe usarse como herramienta para logra la clasificación clínica de los pacientes. El abordaje correcto de la enfermedad, debido a que todavía no existe tratamiento, debe incluir, además del manejo clínico interdisciplinario, la prevención mediante el consejo genético basado en el diagnóstico molecular preciso de la condición de portador o portadora.

  6. Feeding behaviour, digestibility, energy balance and productive performance of lactating goats fed forage-based and forage-free diets

    Directory of Open Access Journals (Sweden)

    Gianni Matteo Crovetto

    2010-01-01

    Full Text Available Six lactating Saanen goats have been used in a Latin Square design to evaluate a grass-based diet (G, a hay-based diet(H and a nonforage diet (NF. On dry matter, grass and hay contributed for 55% of the diets and had 13.7 and 16.1%CP, 55.4 and 49.4% NDF, 38.0 and 31.6% ADF, respectively. Diet NF had beet pulp, cracked carob beans and whole cottonseedas main ingredients, with more than 75% of the particles greater than 2 mm.Independently of the dietary treatment, the goats spent more time eating than ruminating. Diet NF proved to be effectivein stimulating chewing activity, despite a trend for a lower chewing activity for eating (178, 185, 125 min/kg DMIfor diets G, H and NF, respectively, but not for ruminating (84, 80, 80 min/kg DMI for diets G, H and NF, respectively.Feed intake did not differ among diets, while regarding digestibility diet NF had the highest values for DM (74.1%, OM(75.7% and non-fibrous carbohydrates (92.0%, but the lowest for ADF (44.5%. For treatments G, H and NF milk yieldswere 3011, 3688 and 3212 g/d (P2.96% (Pml, PC18:0, C18:1 and C18:3 in comparison to the other two diets. No difference among treatments was recorded for CLA.Intake energy was digested to a lesser extent for diet G (68.9, 70.0, 72.7%, Pquality forage. Urinary energy losses reflected the corresponding protein contents of the diets, while no difference wasrecorded for methane production. ME resulted higher for diet NF (60.0, 60.7, 65.1% of the intake energy, Pheat production and milk energy yield were similar in the three treatments. Diet NF had a higher ME content (11.13,11.26, 11.93 MJ/kg DM, P0.69 and NEl (7.20, 7.93, 8.30 MJ/kg DM.It is concluded from the study that a nonforage diet with an adequate amount of structured fibre could substitute a rationbased on poor quality forage in lactating goats; however, good forage seems to enhance milk performance to a greaterextent.

  7. Diet, atherosclerosis, and fish oil.

    Science.gov (United States)

    Connor, W E; Connor, S L

    1990-01-01

    The principal goal of dietary prevention and treatment of atherosclerotic coronary heart disease is the achievement of physiological levels of the plasma total and LDL cholesterol, triglyceride, and VLDL. These goals have been well delineated by the National Cholesterol Education Program of the National Heart, Lung and Blood Institute and the American Heart Association. Dietary treatment is first accomplished by enhancing LDL receptor activity and at the same time depressing liver synthesis of cholesterol and triglyceride. Both dietary cholesterol and saturated fat decrease LDL receptor activity and inhibit the removal of LDL from the plasma by the liver. Saturated fat decreases LDL receptor activity, especially when cholesterol is concurrently present in the diet. The total amount of dietary fat is of importance also. The greater the flux of chylomicron remnants is into the liver, the greater is the influx of cholesterol ester. In addition, factors that affect VLDL and LDL synthesis could be important. These include excessive calories (obesity), which enhance triglyceride and VLDL and hence LDL synthesis. Weight loss and omega-3 fatty acids from fish oil depress synthesis of both VLDL and triglyceride in the liver. The optimal diet for the treatment of children and adults to prevent coronary disease has the following characteristics: cholesterol (100 mg/day), total fat (20% of calories, 6% saturated with the balance from omega-3 and omega-6 polyunsaturated and monounsaturated fat), carbohydrate (65% of calories, two thirds from starch including 11 to 15 gm of soluble fiber), and protein (15% of calories). This low-fat, high-carbohydrate diet can lower the plasma cholesterol 18% to 21%. This diet is also an antithrombotic diet, thrombosis being another major consideration in preventing coronary heart disease. Dietary therapy is the mainstay of the prevention and treatment of coronary heart disease through the control of plasma lipid and lipoprotein levels. The

  8. Degradability of mulberry (Morus alba and rice bran in the rumen of sheep fed different diets

    Directory of Open Access Journals (Sweden)

    Dwi Yulistiani

    2008-12-01

    Full Text Available The experiment was conducted to investigate degradation of dry matter (DM and protein of mulberry and rice bran when incubated in nylon bag in the rumen at different incubation times and different rumen environments of rumen-cannulated adult sheep. Three different rumen conditions were created by feeding the three rumen-cannulated sheep with urea-treated rice straw as basal diet and offered with three supplemental treatment diets on different source of energy and nitrogen. Mulberry, urea and rice bran were used as source of fermentable energy and protein. Treatments consisted of control diet mulberry and molasses (T0; 50% mulberry was replaced by rice bran and urea (T1; and 100% of mulberry was replaced with rice bran and urea (T2. The diets were formulated in iso protein and iso energy. Supplemental diets were offered at 1.2% BW. The study was conducted in three periods. For each period, the sheep was offered with one of three supplemental treatment diets. The nylon bags each, contains sample of either mulberrry or rice bran were incubated in the rumen of sheep at different incubation times in reverse order (48, 24, 12, 9, 6, and 3h. Degradation characteristic data were obtained by analyzing degradability data with the equation of p = a+b(1-e-ct using Neway computer package. Data of degradation characteristic, degradability of DM and CP, DMI, rumen NH3-N and pH were subjected to analysis of variance (ANOVA using a SAS software package. The results showed that the dry matter intake (DMI and rumen pH were not significantly different between diets. The rumen ammonia concentration of T1 and T2 was significantly higher than that of T0. However, the rumen ammonia concentration was higher than that of critical value for rumen microbial synthesis (>5mg/100ml. The rate (c value of DM degradability of mulberry and rice bran was affected by diet treaments, where T2 diet resulted in lower c of mulberry and rice bran. Only CP degradability of mulberry on

  9. Effects of lorcaserin on fat and lean mass loss in obese and overweight patients without and with type 2 diabetes mellitus: the BLOSSOM and BLOOM-DM studies.

    Science.gov (United States)

    Apovian, C; Palmer, K; Fain, R; Perdomo, C; Rubino, D

    2016-09-01

    Body composition was determined using dual-energy X-ray absorptiometry (DXA) in a subset of patients without (BLOSSOM) and with (BLOOM-DM) type 2 diabetes who received diet and exercise counselling along with either lorcaserin 10 mg twice daily or placebo. DXA scans were performed on study day 1 (baseline), week 24 and week 52. Baseline demographics of the subpopulations (without diabetes, n = 189; with diabetes, n = 63) were similar between studies and representative of their study populations. At week 52, patients without diabetes on lorcaserin lost significantly more fat mass relative to those on placebo (-12.06% vs -5.93%; p = 0.008). In patients with diabetes, fat mass was also decreased with lorcaserin relative to placebo (-9.87% vs -1.65%; p fat mass was lost in the trunk region with lorcaserin compared with placebo (without diabetes: -3.31% vs -2.05%; with diabetes: -3.65% vs -0.36%). Weight loss with lorcaserin was associated with a greater degree of fat mass loss than lean mass loss, and most of the fat mass lost for patients without and with diabetes was from the central region of the body. © 2016 John Wiley & Sons Ltd.

  10. A diet containing dried chicory root does not protect against post-weaning diarrhoea in an E. coli challenge model using piglets weaned at 7 weeks of age

    DEFF Research Database (Denmark)

    Hedemann, Mette Skou; Bach Knudsen, Knud Erik

    2010-01-01

    This study aimed to investigate whether fructan from dried chicory root provided protection against E. coli induced post-weaning diarrhoea in an experimental challenge model. Piglets from 6 litters, 8 piglets per litter, were included in the experiment. Starting 10 d prior to weaning, 4 piglets per...... litter received a control diet (0.9% fructan of DM) and 4 piglets received an experimental diet containing 20% dried chicory root (11.6% fructan of DM). The piglets were weaned at 7 weeks of age. On d 2 and 3 post-weaning half of the piglets were orally challenged with E. coli O149, the remaining piglets...

  11. The correlation of reproduction-related gene expression with germ cell number in DM and PLL gilts.

    Science.gov (United States)

    Hu, Yan-Biao; Pan, Zeng-Xiang; Xu, Dan; Xu, Yin-Xue; Liu, Hong-Lin; Huang, Rui-Hua; Hu, Zhi-Gang

    2006-09-01

    In this study, the ovarian germ cell number was counted in 3-week-old Duroc x Meishan (DM, n=30) and PIC x (Landrace x Large White) (PLL, n=53) gilts, and the mRNA expression levels of four reproduction-related genes were investigated by quantitative RT-PCR. Correlation of germ cell number with the expression level of these genes was analyzed. Results showed that the germ cell number of DM was significantly higher than that of PLL gilts (PPLL gilts (P=0.269). No significant correlation existed between germ cell number and ovarian weight in the two gilt groups (R=0.335, P=0.07; R=0.119, P=0.398, respectively). A significant correlation was found between the germ cell number and expression level of ESR and IGF1R mRNA in DM gilts (R=0.648, PPLL gilts (R=0.435, PPLL gilts.

  12. Beyond the standard $\\Lambda$CDM cosmology: the observed structure of DM halos and the shape of the power spectrum

    CERN Document Server

    Demiański, M

    2015-01-01

    To restore the evolutionary history of the Dark Matter (DM) dominated objects -- galaxies and clusters of galaxies. Analyze the observational data to reveal correlations between the virial mass, $M_{vir}$, of halos and main properties of their central cores, namely, the mean DM density, pressure and entropy, and the redshifts of halo formation, $z_f$. These correlations indicate a high degree of self similarity of both the process of halos formation and the internal structure of relaxed halos. We confirm the CDM--like shape of the small scale power spectrum. However our reconstruction of evolutionary history of observed objects differs from expectations of the standard $\\Lambda$CDM cosmology and requires either multicomponent composition of DM or more complex primordial power spectrum of density perturbations with significant excess of power at scales of clusters of galaxies and larger. This approach seems to be quite efficient and suitably supplements the current investigations of galaxies at large redshifts...

  13. [Therapy in diabetes education. Where are we?].

    Science.gov (United States)

    Isla Pera, Pilar

    2011-06-01

    Patients with diabetes mellitus (DM) who receive no education cannot make informed decisions to maintain acceptable metabolic control, increasing the likelihood of complications [1]. Education and prevention of diabetes mellitus (DM) are the central theme of World Diabetes Day during the period 2009/2073. The key messages of this campaign advocating: 1) Know the risks of DM and its warning signs, 2) Know what to do and who to call and 3) Learn how to manage and control. Education is the primary theme of this campaign promoted by the International Diabetes Federation (IDF) and the World Health Organization (WHO) [1].

  14. Crystal Structure of Allophycocyanin from Marine Cyanobacterium Phormidium sp. A09DM.

    Science.gov (United States)

    Sonani, Ravi Raghav; Gupta, Gagan Deep; Madamwar, Datta; Kumar, Vinay

    2015-01-01

    Isolated phycobilisome (PBS) sub-assemblies have been widely subjected to X-ray crystallography analysis to obtain greater insights into the structure-function relationship of this light harvesting complex. Allophycocyanin (APC) is the phycobiliprotein always found in the PBS core complex. Phycocyanobilin (PCB) chromophores, covalently bound to conserved Cys residues of α- and β- subunits of APC, are responsible for solar energy absorption from phycocyanin and for transfer to photosynthetic apparatus. In the known APC structures, heterodimers of α- and β- subunits (known as αβ monomers) assemble as trimer or hexamer. We here for the first time report the crystal structure of APC isolated from a marine cyanobacterium (Phormidium sp. A09DM). The crystal structure has been refined against all the observed data to the resolution of 2.51 Å to Rwork (Rfree) of 0.158 (0.229) with good stereochemistry of the atomic model. The Phormidium protein exists as a trimer of αβ monomers in solution and in crystal lattice. The overall tertiary structures of α- and β- subunits, and trimeric quaternary fold of the Phormidium protein resemble the other known APC structures. Also, configuration and conformation of the two covalently bound PCB chromophores in the marine APC are same as those observed in fresh water cyanobacteria and marine red algae. More hydrophobic residues, however, constitute the environment of the chromophore bound to α-subunit of the Phormidium protein, owing mainly to amino acid substitutions in the marine protein.

  15. DM Ori: A Young Star Occulted by a Disturbance in Its Protoplanetary Disk

    Science.gov (United States)

    Rodriguez, Joseph E.; Stassun, Keivan G.; Cargile, Phillip; Shappee, Benjamin J.; Siverd, Robert J.; Pepper, Joshua; Lund, Michael B.; Kochanek, Christopher S.; James, David; Kuhn, Rudolf B.; Beatty, Thomas G.; Gaudi, B. Scott; Weintraub, David A.; Stanek, Krzysztof Z.; Holoien, Thomas W.-S.; Prieto, Jose L.; Feldman, Daniel M.; Espaillat, Catherine C.

    2016-11-01

    In some planet formation theories, protoplanets grow gravitationally within a young star’s protoplanetary disk, a signature of which may be a localized disturbance in the disk’s radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South project and the All-Sky Automated Survey for SuperNovae, combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by ∼1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth ∼1.7 mag). We constrain the duration of the 2000–2002 dimming to be 6 au from the host star, moving at ∼14.6 km s‑1 and is ∼4.9 au in width. This localized structure may indicate a disturbance such as that which may be caused by a protoplanet early in its formation.

  16. The Distribution and Chemistry of H$_2$CO in the DM Tau Protoplanetary Disk

    CERN Document Server

    Loomis, Ryan A; Öberg, Karin I; Guzman, Viviana V; Andrews, Sean M

    2015-01-01

    H$_2$CO ice on dust grains is an important precursor of complex organic molecules (COMs). H$_2$CO gas can be readily observed in protoplanetary disks and may be used to trace COM chemistry. However, its utility as a COM probe is currently limited by a lack of constraints on the relative contributions of two different formation pathways: on icy grain-surfaces and in the gas-phase. We use archival ALMA observations of the resolved distribution of H$_2$CO emission in the disk around the young low-mass star DM Tau to assess the relative importance of these formation routes. The observed H$_2$CO emission has a centrally peaked and radially broad brightness profile (extending out to 500 AU). We compare these observations with disk chemistry models with and without grain-surface formation reactions, and find that both gas and grain-surface chemistry are necessary to explain the spatial distribution of the emission. Gas-phase H$_2$CO production is responsible for the observed central peak, while grain-surface chemist...

  17. A White Light Megaflare on the dM4.5e Star YZ CMi

    CERN Document Server

    Kowalski, Adam F; Holtzman, Jon A; Wisniewski, John P; Hilton, Eric J

    2010-01-01

    On UT 2009 January 16, we observed a white light megaflare on the dM4.5e star YZ CMi as part of a long-term spectroscopic flare-monitoring campaign to constrain the spectral shape of optical flare continuum emission. Simultaneous U-band photometric and 3350A-9260A spectroscopic observations were obtained during 1.3 hours of the flare decay. The event persisted for more than 7 hours and at flare peak, the U-band flux was almost 6 magnitudes brighter than in the quiescent state. The properties of this flare mark it as one of the most energetic and longest-lasting white light flares ever to be observed on an isolated low-mass star. We present the U-band flare energetics and a flare continuum analysis. For the first time, we show convincingly with spectra that the shape of the blue continuum from 3350A to 4800A can be represented as a sum of two components: a Balmer continuum as predicted by the Allred et al radiative hydrodynamic flare models and a T ~ 10,000K blackbody emission component as suggested by many pr...

  18. A novel design of subminiature star sensor's imaging system based on TMS320DM3730

    Science.gov (United States)

    Liu, Meiying; Wang, Hu; Wen, Desheng; Yang, Shaodong

    2017-02-01

    Development of the next generation star sensor is tending to miniaturization, low cost and low power consumption, so the imaging system based on FPGA in the past could not meet its developing requirements. A novel design of digital imaging system is discussed in this paper. Combined with the MT9P031 CMOS image sensor's timing sequence and working mode, the sensor driving circuit and image data memory circuit were implemented with the main control unit TMS320DM3730. In order to make the hardware system has the advantage of small size and light weight, the hardware adopted miniaturization design. The software simulation and experimental results demonstrated that the designed imaging system was reasonable, the function of tunable integration time and selectable window readout modes were realized. The communication with computer was exact. The system has the advantage of the powerful image processing, small-size, compact, stable, reliable and low power consumption. The whole system volume is 40 mm *40 mm *40mm,the system weight is 105g, the system power consumption is lower than 1w. This design provided a feasible solution for the realization of the subminiature star sensor's imaging system.

  19. The Influence of Diabetic Experience against the Behavior of DM Controlling

    Directory of Open Access Journals (Sweden)

    Yusran Haskas

    2016-06-01

    Full Text Available The behavior control of diabetes mellitus can improve the life quality of patient through planning specific behaviors. The behavior can be reflected by the experience that diabetes itself or observed in surrounding. Therefore, this study was conducted to investigate the effect on behavior of diabetics experience against diabetes control. This type of study is explanatory research using cross sectional design. The collecting data was using diabetics experience related diabetes disease. The consecutive sampling technique was used to obtain 134 samples. Data were analyzed with chi square test. The results showed that the average 62.2% of diabetics to control diabetes well have a pleasant and unpleasant experience. Chi-square test results showed that diabetics experience have influence against the behavior diabetes control (p = 0.043. Findings influence on diabetics experience against the behavior control diabetes have implications for providing information and support positive consistently in order to become a source of knowledge and experience in improving the behavior good control of DM.

  20. Sensitive limits on the abundance of cold water vapor in the DM Tau protoplanetary disk

    CERN Document Server

    Bergin, E A; Brinch, C; Fogel, J; Yildiz, U A; Kristensen, L E; van~Dishoeck, E F; Bell, T A; Blake, G A; Cernicharo, J; Dominik, C; Lis, D; Melnick, G; Neufeld, D; Panic, O; Pearson, J C; Bachiller, R; Baudry, A; Benedettini, M; Benz, A O; Bjerkeli, P; Bontemps, S; Braine, J; Bruderer, S; Caselli, P; Codella, C; Daniel, F; di Giorgio, A M; Doty, S D; Encrenaz, P; Fich, M; Fuente, A; Giannini, T; Goicoechea, J R; de Graauw, Th; Helmich, F; Herczeg, G J; Herpin, F; Jacq, T; Johnstone, D; Jorgensen, J K; Larsson, B; Liseau, R; Marseille, M; McCoey, C; Nisini, B; Olberg, M; Parise, B; Plume, R; Risacher, C; Santiago-Garcia, J; Saraceno, P; Shipman, R; Tafalla, M; van Kempen, T A; Visser, R; Wampfler, S F; Wyrowski, F; van der Tak, F; Jellema, W; Tielens, A G G M; Hartogh, P; Stutzki, J; Szczerba, R

    2010-01-01

    We performed a sensitive search for the ground-state emission lines of ortho- and para-water vapor in the DM Tau protoplanetary disk using the Herschel/HIFI instrument. No strong lines are detected down to 3sigma levels in 0.5 km/s channels of 4.2 mK for the 1_{10}--1_{01} line and 12.6 mK for the 1_{11}--0_{00} line. We report a very tentative detection, however, of the 1_{10}--1_{01} line in the Wide Band Spectrometer, with a strength of T_{mb}=2.7 mK, a width of 5.6 km/s and an integrated intensity of 16.0 mK km/s. The latter constitutes a 6sigma detection. Regardless of the reality of this tentative detection, model calculations indicate that our sensitive limits on the line strengths preclude efficient desorption of water in the UV illuminated regions of the disk. We hypothesize that more than 95-99% of the water ice is locked up in coagulated grains that have settled to the midplane.

  1. ArDM: a ton-scale LAr detector for direct Dark Matter searches

    CERN Document Server

    AUTHOR|(CDS)2072225; Badertscher, A.; Boccone, V.; Bueno, A.; Carmona-Benitez, M.C.; Coleman, J.; Creus, W.; Curioni, A.; Daniel, M.; Dawe, E.J.; Degunda, U.; Gendotti, A.; Epprecht, L.; Horikawa, S.; Kaufmann, L.; Knecht, L.; Laffranchi, M.; Lazzaro, C.; Lightfoot, P.K.; Lussi, D.; Lozano, J.; Mavrokoridis, K.; Melgarejo, A.; Mijakowski, P.; Natterer, G.; Navas-Concha, S.; Otyugova, P.; de Prado, M.; Przewlocki, P.; Regenfus, C.; Resnati, F.; Robinson, M.; Rochet, J.; Romero, L.; Rondio, E.; Rubbia, A.; Scotto-Lavina, L.; Spooner, N.J.C.; Strauss, T.; Touramanis, C.; Ulbricht, J.; Viant, T.

    2011-01-01

    The Argon Dark Matter (ArDM-1t) experiment is a ton-scale liquid argon (LAr) double-phase time projection chamber designed for direct Dark Matter searches. Such a device allows to explore the low energy frontier in LAr with a charge imaging detector. The ionization charge is extracted from the liquid into the gas phase and there amplified by the use of a Large Electron Multiplier in order to reduce the detection threshold. Direct detection of the ionization charge with fine spatial granularity, combined with a measurement of the amplitude and time evolution of the associated primary scintillation light, provide powerful tools for the identification of WIMP interactions against the background due to electrons, photons and possibly neutrons if scattering more than once. A one ton LAr detector is presently installed on surface at CERN to fully test all functionalities and it will be soon moved to an underground location. We will emphasize here the lessons learned from such a device for the design of a large LAr ...

  2. DM Ori: A Young Star Occulted by a Disturbance in its Protoplanetary Disk

    CERN Document Server

    Rodriguez, Joseph E; Cargile, Phillip; Shappee, Benjamin J; Siverd, Robert J; Pepper, Joshua; Lund, Michael B; Kochanek, Christopher S; James, David; Kuhn, Rudolf B; Beatty, Thomas G; Gaudi, B Scott; Weintraub, David A; Stanek, Krzysztof Z; Holoien, Thomas W S; Prieto, Jose L; Feldman, Daniel M; Espaillat, Catherine C

    2016-01-01

    In some planet formation theories, protoplanets grow gravitationally within a young star's protoplanetary disk, a signature of which may be a localized disturbance in the disk's radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South (KELT-South) project and the All-Sky Automated Survey for SuperNovae (ASAS-SN), combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by $\\sim$1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth $\\sim$1.7 mag). We constrain the duration of the 2000-2002 dimming to be $$6 AU from the host star, moving at $\\sim$14.6 km/s, and is $\\sim$4.9 AU in width. This localized structure may indicate a disturbance such as may be caused by a protoplanet early in its formation.

  3. Faint dwarfs as a test of DM models: WDM vs. CDM

    CERN Document Server

    Governato, Fabio; Pontzen, Andrew; Loebman, Sarah; Reed, Darren; Brooks, Alyson M; Behroozi, Peter; Christensen, Charlotte; Madau, Piero; Mayer, Lucio; Shen, Sijing; Walker, Matthew; Quinn, Thomas; Wadsley, James

    2014-01-01

    We use high resolution Hydro$+$N-Body cosmological simulations to compare the assembly and evolution of a small field dwarf (stellar mass ~ 10$^{6-7}$ M$\\odot$, total mass 10$^{10}$ M$\\odot$ in $\\Lambda$ dominated CDM and 2keV WDM cosmologies. We find that star formation (SF) in the WDM model is reduced and delayed by 1-2 Gyr relative to the CDM model, independently of the details of SF and feedback. Independent of the DM model, but proportionally to the SF efficiency, gas outflows lower the central mass density through `dynamical heating', such that all realizations have circular velocities $<$ 20kms at 500$~$pc, in agreement with local kinematic constraints. As a result of dynamical heating, older stars are less centrally concentrated than younger stars, similar to stellar population gradients observed in nearby dwarf galaxies. We translate our simulations into artificial color-magnitude diagrams and star formation histories in order to directly compare to available observations. The simulated galaxies f...

  4. Reproducing properties of MW dSphs as descendants of DM-free TDGs

    CERN Document Server

    Yang, Yanbin; Fouquet, Sylvain; Flores, Hector; Puech, Mathieu; Pawlowski, Marcel S; Kroupa, Pavel

    2014-01-01

    The Milky Way (MW) dwarf spheroidal (dSph) satellites are known to be the most dark-matter (DM) dominated galaxies with estimates of dark to baryonic matter reaching even above one hundred. It comes from the assumption that dwarfs are dynamically supported by their observed velocity dispersions. However their spatial distributions around the MW is not at random and this could challenge their origin, previously assumed to be residues of primordial galaxies accreted by the MW potential. Here we show that alternatively, dSphs could be the residue of tidal dwarf galaxies (TDGs), which would have interacted with the Galactic hot gaseous halo and disk. TDGs are gas-rich and have been formed in a tidal tail produced during an ancient merger event at the M31 location, and expelled towards the MW. Our simulations show that low-mass TDGs are fragile to an interaction with the MW disk and halo hot gas. During the interaction, their stellar content is progressively driven out of equilibrium and strongly expands, leading ...

  5. Longevity and diet. Myth or pragmatism?

    Science.gov (United States)

    Chrysohoou, Christina; Stefanadis, Christodoulos

    2013-12-01

    Longevity is a very complex phenomenon, because many environmental, behavioral, socio-demographic and dietary factors influence the physiological pathways of aging and life-expectancy. Nutrition has been recognized to have an important impact on overall mortality and morbidity; and its role in extending life expectancy has been the object of extensive scientific research. This paper reviews the pathophysiological mechanisms that potentially link aging with diet and the scientific evidence supporting the anti-aging effect of the traditional Mediterranean diet, as well as of some specific foods. The diet and several of its components have additionally been shown to have beneficial effects on the co-morbidities typical of elderly populations. Furthermore, the epigenetic effects of diet on the aging process - through calorie restriction and the consumption of foods like red wine, orange juice, probiotics and prebiotics - have attracted scientific interest. Some, such as dark chocolate, red wine, nuts, beans, avocados are being promoted as anti-aging foods, due to their anti-oxidative and anti-inflammatory properties. Finally, an important moderator in the relationship between diet, longevity and human health remains the socio-economic status of individual, as a healthy diet, due to its higher cost, is closely related to higher financial and educational status.

  6. Vegetarian diets and children.

    Science.gov (United States)

    Sanders, T A; Reddy, S

    1994-05-01

    The diets and growth of children reared on vegetarian diets are reviewed. Excessive bulk combined with low energy density can be a problem for children aged Diets that have a high content of phytate and other modifiers of mineral absorption are associated with an increased prevalence of rickets and iron-deficiency anemia. Vitamin B-12 deficiency is a real hazard in unsupplemented or unfortified vegan and vegetarian diets. It is suggested that vegans and vegetarians should use oils with a low ratio of linoleic to linolenic acid in view of the recently recognized role of docosahexaenoic acid in visual functioning. If known pitfalls are avoided, the growth and development of children reared on both vegan and vegetarian diets appears normal.

  7. [Diet and atherosclerosis].

    Science.gov (United States)

    Garrido, J A; Garcés, C; de Oya, M

    1998-01-01

    The relationship between diet and atherosclerosis is due to the diet influence on lipoprotein composition. However, because of the multifactorial basis of the atherosclerosis, diet components have another potential intervention mechanisms in the atherosclerosis process, such as the influence on other cardiovascular risk factors (hypertension, obesity, diabetes) or the influence on the coagulation system and the relationship endothelium-platelets. We will review the effect of diet components on these factors, specially its effects on the haemostasia system, which alteration is responsible for provoking ischemic heart disease. We have to consider that the main objective when treating dyslipidaemias, besides of avoiding acute pancreatitis in cases of strong hypertrigliceridaemia, is to prevent arteriosclerosis development and its clinical manifestations such as ischemic heart disease. Besides, we know that genetic, in addition to provoke familial susceptibility to atherosclerosis, has an essential importance in the response to ambiental factors as diet is.

  8. 爱普生推出全方位家庭娱乐一体机EMP-DM1

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    5月23日,爱普生(中国)有限公司在北京举行了题为“随心动,随心映——爱普生私人FUN映机EMP—DM1”的新品发布会。作为一款入门级家用投影机,EMP—DM1采用了.all in one的设计理念,将投影机、音响、

  9. Beyond the standard $\\Lambda$CDM cosmology: the observed structure of DM halos and the shape of the power spectrum

    OpenAIRE

    Demiański, M.; Doroshkevich, A. G.

    2015-01-01

    Recent advances in observational astronomy allow to study various groups of Dark Matter (DM) dominated objects from the dwarf spheroidal (dSph) galaxies to clusters of galaxies that span the mass range from $10^{6} M_{\\odot}$ to $10^{15} M_{\\odot}$. To analyze data of this divers collection of objects we used a simple toy model of spherical DM halo formation that was initially proposed by Peebles. This model introduced the concept of the epoch or redshift of halo formation. Using this concept...

  10. Comparison of DAMA/LIBRA and DM ICE Results using Information Theory to Rule out Dark Matter Claims

    CERN Document Server

    Cline, David

    2015-01-01

    We study the details of the DAMA/LIBRA results and compare those with the recent published DM Ice results of ICE Cube. In various recent papers, it was shown that the 40K peak on DAMA/LIBRA data leaves no room for a Dark Matter signal in the bulk of the data. Using Information Theory for the different types of detection environments, we show that annual variation calculations and the DM Ice data reinforce the claims that the DAMA/LIBRA detector is not observing Dark Matter WIMPs.

  11. Diet for rapid weight loss

    Science.gov (United States)

    Academy of Nutrition and Dietetics. Staying away from fad diets. Updated January 4, 2016. www.eatright.org/resource/health/weight-loss/fad-diets/staying-away-from-fad-diets . Accessed May 25, 2016. Cowley MA, Brown WA, Considine ...

  12. Diet and Nutrition in Porphyria

    Science.gov (United States)

    ... Art Sale You are here Home Diet and Nutrition A proper diet is important to all individuals, ... alter food intake. Therefore, attention to diet and nutrition is important in almost any disease. Porphyrias are ...

  13. Estimating Apparent Nutrient Digestibility of Diets Containing or Leaf Meals for Growing Rabbits by Two Methods

    Directory of Open Access Journals (Sweden)

    A. M. Safwat

    2015-08-01

    Full Text Available This study aimed to evaluate the nutrient digestibility of growing rabbits fed diets with different levels of either Leucaena leucocephala (LLM or Moringa oleifera (MOLM leaf meals and also to compare total collection and TiO2 marker methods for estimating digestibility. A total of 30 California growing rabbits (1.81±0.19 kg live weight on average were randomly distributed into five experimental groups of six rabbits each and were housed in individual cages. The groups were control, 30% LLM, 40% LLM, 30% MOLM, and 40% MOLM. All groups received pelleted diets for two weeks; diets also contained 4 g/kg titanium dioxide as dietary marker. Daily feed intake was recorded during the whole experimental period and total feces were collected daily and weighed individually during four days. The results showed that there were no difference (p>0.05 in feed, dry matter (DM, organic matter (OM, crude protein (CP, digestible energy, and crude fiber (CF intake between the control group and the other experimental groups. The apparent digestibility values of DM, OM, CP, CF, acid detergent fiber, and gross energy were the highest for control group (p = 0.001, meanwhile MOLM diets had generally higher nutrient digestibility coefficients than LLM diets. Increasing the inclusion level of leaf meal in the diet from 30% to 40% improved the digestibility of CF from 45.02% to 51.69% for LLM and from 48.11% to 55.89% for MOLM. Similar results for apparent nutrient digestibility coefficients were obtained when either total collection or indigestible marker method was used. In conclusion, the digestibility of MOLM containing diets were better than LLM diets, furthermore TiO2 as an external marker could be used as a simple, practical and reliable method to estimate nutrients digestibility in rabbit diets.

  14. Frequency and duration of breast-feeding in Cuban children with Type 1 diabetes mellitus (DM Freqüência e duração do aleitamento materno em crianças cubanas com Diabetes Mellitus Tipo 1

    Directory of Open Access Journals (Sweden)

    Fernando Collado-Mesa

    1998-12-01

    Full Text Available It has been suggested that breastfeeding is a protective factor against Type 1 DM due to anti-infection properties or delay in exposure to other agents in the diet. A descriptive study was carried out using data from the Cuban National Registry of Childhood-Onset Diabetes Mellitus (CNRDM. The goal of the study was to determine the frequency and duration of breast-feeding in Cuban children with Type 1 DM. Four hundred and eighty-six children were registered in the CNRDM between January 1, 1988, and December 31, 1993. Breast-feeding data was obtained from two hundred and sixty three (54.1% of the total registered children. Of these children, two hundred and one (76.4% were breastfed. The median duration of breast-feeding was three months (Total range 144 months. No statistically significant association was found between the mean age at DM or the clinical profile at diagnosis and the breast-feeding duration groups (p >0.05, respectively. In conclusion, Cuban children with Type 1 DM have relatively low frequency of breast-feeding. When breast-feeding is studied without stratifying for different types of breast-feeding (e.g. exclusive and non-exclusive, there is no association found with the age at DM diagnosis or the clinical profiles at diagnosis.Há evidências de que o aleitamento materno age como um fator protetor contra o DM Tipo 1 devido a propriedades antiinfecciosas ou porque retarda a exposição a outros agentes na dieta. Foi realizado um estudo descritivo com dados do Registro Nacional Cubanas de Diabetes Mellitus na Infância (CNRDM. O objetivo desse estudo era determinar a freqüência e duração do aleitamento materno em crianças cubanas com DM Tipo 1. Quatrocentas e oitenta e seis crianças foram cadastradas no CNRDM entre 1 de janeiro de 1988 e 31 de dezembro de 1993. Os dados sobre aleitamento materno foram obtidos de duzentas e sessenta e três crianças (54.1% do total registrado. Dessas crianças, duzentas e uma (76.4% foram

  15. CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

    Directory of Open Access Journals (Sweden)

    Hashim Amel A.

    2016-01-01

    Full Text Available Uvod: U ovoj studiji istraživali smo odnos između adiponektina i markera koštanih promena kod egipatske dece i ado­lescenata sa T1DM, uticaj trajanja bolesti na ove markere, kao i potencijalne korelacije između adiponektina i ko­štanih markera kod ovih pacijenata.

  16. 在TMS320DM642上实现嵌入式TCP/IP协议栈%Embedded Solution of TCP/IP Protocol Stack Based on TMS320DM642

    Institute of Scientific and Technical Information of China (English)

    王平; 孙乐美

    2007-01-01

    实现了一个运行在数字信号处理器TMS320DM642上的嵌入式TCP/IP协议栈.对TCP/IP协议中的IP协议、ARP协议、UDP协议进行分析,完成基于TCP/IP协议的嵌入式网络系统.

  17. Eating Order: A 13-Week Trust Model Class for Dieting Casualties

    Science.gov (United States)

    Jackson, Elizabeth G.

    2008-01-01

    Chronic dieting distorts eating behaviors and causes weight escalation. Desperation about losing weight results in pursuit of extreme weight loss measures. Instead of offering yet another diet, nutrition educators can teach chronic dieters (dieting casualties) to develop eating competence. Eating Order, a 13-week class for chronic dieters based on…

  18. Dukungan keluarga dan jadwal makan dan sebelum edukasi berhubungan dengan kepatuhan jadwal makan pasien diabetes melitus (DM tipe 2 rawat jalan yang mendapat konseling gizi di RSUD Kota Yogyakarta

    Directory of Open Access Journals (Sweden)

    Martalena Br Purba

    2010-11-01

    Full Text Available Background: Diabetes mellitus (DM is a clinical syndrome with symptoms of hyperglycemia, urinary glucose excretion and disorder of insulin mechanism. Approximately 90-95% of diabetic patients suffer from type 2 DM. Various studies show that compliance to treatment of chronic disease in general is low. Compliance to eating or food frequency amongst DM patients in hospital in particular is very low. The success of self management of blood glucose (SMBG needs participation of the patient, families, and educator team. Objective: To study the factors affecting eating compliance particularly eating schedule among type 2 diabetic out-patient who had nutrition counseling in RSUD Kota Yogyakarta. Method: It was an observasional study with cross sectional design and purposive sampling. Data collection was done in October 2008 with 98 subjects. The sampel were type 2 diabetic out-patients according to inclusion criteria at out- patient clinic in RSUD Kota Yogyakarta. Statistical test with 95% confidence interval was applied to investigate factors infuenced eating compliance. Results: There were no correlations between eating compliance and disease duration (RP=  1,253 and p =0,403, and also with type of occupation (RP= 1,047 dan p= 1,000. However, it was found that family support affected eating compliance (RP= 1,723 dan p= 0,025 as well as eating schedule before nutrition counseling (RP = 2,151 and p= 0,02. Conclusion: Duration of disease and type of occupation did not affect eating compliance. Nevertheless, family support and eating schedule before nutrition education affected eating compliance among type 2 DM out-patients in RSUD Kota Yogyakarta.

  19. Response of broiler finishers to diets containing graded levels of processed castor oil bean (Ricinus communis L) meal.

    Science.gov (United States)

    Ani, A O; Okorie, A U

    2009-04-01

    A 4-week feeding experiment was conducted to determine the effects of graded levels of dehulled and cooked castor oil bean (Ricinus communis L) meal on the performance of broiler finishers. Castor oil bean seeds were dehulled and detoxified by cooking in two stages at 100 degrees C for 50 min per cooking. Sixty 6-week-old broiler birds (Anak strain) were randomly divided into four groups of 15 birds each. The groups were fed four isocaloric (2.90 Mcal of metabolizable energy/kg) and isonitrogenous (21% crude protein) diets containing 0%, 10%, 15% and 20% dehulled and cooked castor oil bean meal (CBM) for 4 weeks. Results showed that there were significant (p 0.05) different from the ADWG of birds on 10% CBM diet. Birds fed diets containing10% and 15% levels of CBM had similar and non-significant (p > 0.05) ADWG. Birds fed 20% CBM diet had the least (p 0.05) PCV values. Birds fed diets containing 0%, 10% and 15% levels of CBM had similar and significantly (p < 0.05) lower heamoglobin than birds fed 20% CBM diets. There were also significant (p < 0.05) differences among treatments in dry matter (DM), nitrogen, ether extract (EE) and nitrogen-free extract (NFE) retention. Birds fed 0% CBM diet had significantly (p < 0.05) higher retention of DM, nitrogen and NFE than birds on 10%, 15% and 20% CBM diets. Birds fed 10% CBM diet had significantly (p < 0.05) higher DM, nitrogen and NFE retention than birds on 15% and 20% CBM diets. The lowest retention of DM, nitrogen and NFE was recorded at the 20% CBM inclusion level. Birds fed 0% CBM diet had significantly (p < 0.05) higher EE retention than birds on 15% and 20% CBM diets. The lowest EE retention was observed at the 20% CBM inclusion level. The results of the study indicate that up to 10% dehulled and cooked CBM can be included in broiler finisher rations for optimum performance.

  20. Effects of alfalfa germplasm and stage of maturity on digestive process and productive response of dairy cows fed alfalfa hay-based diets

    Directory of Open Access Journals (Sweden)

    Igino Andrighetto

    2010-01-01

    Full Text Available The effects on the digestive process and the productive performances of dairy cows fed diets containing alfalfa hay from  different germplasms and maturity were assessed in the present study. Three different lots of first-cut alfalfa hay were  used in the study: the improved variety “Boreal”, harvested at two consecutive maturity stages (early flowering and full  flowering and the ecotype “Vogherese”, at full flowering. Cutting the plant at an earlier stage of maturity improved hay  quality in comparison with the more mature forages (crude protein: 21.4 vs 16.5% DM; P  DM; P  er lignin content for the latter (8.6 vs 8.2% DM; P  tating cows were formulated using an equal amount of corn silage and the maximum inclusion of one of the tested hays  as forage base. The better quality of the early cut hay made it possible to increase its inclusion in the diet up to 44% of  total dietary DM, while the two more mature hays covered only 36% of total DM of the respective diets. According to a  3 x 3 Latin square design, the diets were fed to 3 Italian Brown cows (initial average days in milk 121 ± 24 and milk  yield 20 kg ± 1.3 fitted with ruminal cannula in 3 consecutive periods of 28 d each. Alfalfa stage of maturity and  germplasm did not affect dietary DM intake (average 16 kg/d. Degradability parameters of dietary DM, calculated by in  situ nylon bags technique, showed similar kinetics of rumen disappearance for all diets. No differences were noticed in  the ruminal rate of passage of the solid phase among diets, while the liquid phase showed a slower rate of passage for  the early flowering hay diet. Consistent with the degradation process, the stage of maturity or the alfalfa germplasm did  not affect the rumen fluid data or the in vivo digestibility coefficients of the diets. Milk yield did not show any change due  to either alfalfa maturity or cultivar, while milk protein was lowered when cows received the early cut hay

  1. Are socio-economic disparities in diet quality explained by diet cost?

    Science.gov (United States)

    Monsivais, Pablo; Aggarwal, Anju; Drewnowski, Adam

    2012-06-01

    Socio-economic disparities in nutrition are well documented. This study tested the hypothesis that socio-economic differences in nutrient intakes can be accounted for, in part, by diet cost. A representative sample of 1295 adults in King County (WA) was surveyed in 2008-2009, and usual dietary intakes were assessed based on a food-frequency questionnaire. The monetary value of individual diets was estimated using local retail supermarket prices for 384 foods. Nutrients of concern as identified by the 2005 Dietary Guidelines Advisory Committee were fibre, vitamins A, C and E, calcium, magnesium and potassium. A nutrient density score based on all seven nutrients was another dependent measure. General linear models and linear regressions were used to examine associations among education and income, nutrient density measure and diet cost. Analyses were conducted in 2009-2010. Controlling for energy and other covariates, higher-cost diets were significantly higher in all seven nutrients and in overall nutrient density. Higher education and income were positively and significantly associated with the nutrient density measure, but these effects were greatly attenuated with the inclusion of the cost variable in the model. Socio-economic differences in nutrient intake can be substantially explained by the monetary cost of the diet. The higher cost of more nutritious diets may contribute to socio-economic disparities in health and should be taken into account in the formulation of nutrition and public health policy.

  2. Using Formative Research to Develop a Nutrition Education Resource Aimed at Assisting Low-Income Households in South Africa Adopt a Healthier Diet

    Science.gov (United States)

    Everett-Murphy, K.; De Villiers, A.; Ketterer, E.; Steyn, K.

    2015-01-01

    As part of a comprehensive programme to prevent non-communicable disease in South Africa, there is a need to develop public education campaigns on healthy eating. Urban populations of lower socioeconomic status are a priority target population. This study involved formative research to guide the development of a nutrition resource appropriate to…

  3. Diet and Inflammatory Bowel Disease.

    Science.gov (United States)

    Knight-Sepulveda, Karina; Kais, Susan; Santaolalla, Rebeca; Abreu, Maria T

    2015-08-01

    Patients with inflammatory bowel disease (IBD) are increasingly becoming interested in nonpharmacologic approaches to managing their disease. One of the most frequently asked questions of IBD patients is what they should eat. The role of diet has become very important in the prevention and treatment of IBD. Although there is a general lack of rigorous scientific evidence that demonstrates which diet is best for certain patients, several diets-such as the low-fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet; the specific carbohydrate diet; the anti-inflammatory diet; and the Paleolithic diet-have become popular. This article discusses the diets commonly recommended to IBD patients and reviews the supporting data.

  4. Effects of health education on cognition, diet and lifestyle in obese children%健康教育对肥胖儿童认知、饮食结构及生活方式的影响

    Institute of Scientific and Technical Information of China (English)

    王斐; 陈梦莹; 陈海燕; 史晓燕; 李荣; 李小妹; 陈银花; 李晓南

    2012-01-01

    [目的]探索单次和多次健康教育对肥胖儿童认知,饮食结构、生活方式及体重控制的影响,为儿童肥胖干预的实施提供有效措施. [方法]按照《中国0~18岁儿童青少年体块指数的生长曲线》超重和肥胖诊断标准筛查学龄儿童,对肥胖儿童发放调查问卷,评估肥胖认知、饮食结构及生活方式并分组给予单次或多次健康教育.健康教育的内容包括肥胖的判断和危害,科学的饮食结构、生活方式和心理支持等.6个月后再次进行评估. [结果]共有107名年龄6~13岁的肥胖儿童(男69人,女38人)纳入研究.资料完整90名,其中单次教育组44人,多次教育组46人.1)健康教育后两组儿童和家长对肥胖的认知水平均提高,但多次教育组儿童和家长认知水平显著高于单次教育组(P<0.01);2)干预后,多次教育组总能量及蛋白质、脂肪、碳水化合物摄入量及能量密度均降低(P<0.01),蔬菜份量增加(P<0.05),动物性食物及甜点、薯片的迸食份额明显减少(P<0.01);单次教育组脂肪摄入减少(P<0.01),但总能量、食物份额量无明显改变;3)多次教育组在洋快餐、零食、看电视吃零食频率及看电视时间明显减少(P<0.01),但每日运动时间无明显变化;单次教育组生活方式无显著改变(P>0.05);4)干预后单次教育组BMI-SDS(body mass index-standard deviation score)无明显改变,多次教育组BMI-SDS降低(P<0.05). [结论]对肥胖儿童和家长进行健康教育,尤其是多次教育有助于提高肥胖儿童和家长认知能力,降低儿童总能量摄入,改变饮食结构和生活方式,进而降低BMI.%[Objective] To explore the impacts of single and repetitive health education on the cognition,diet,lifestyle and weight control in obese children, and provide effective measures to childhood obesity intervention. [Methods] According to "Body mass index growth curves for Chinese children adolescents

  5. Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI.

    Science.gov (United States)

    Xia, Wenqing; Rao, Hengyi; Spaeth, Andrea M; Huang, Rong; Tian, Sai; Cai, Rongrong; Sun, Jie; Wang, Shaohua

    2015-12-01

    Type 2 diabetes mellitus (T2DM) and hypertension are both associated with cognitive impairment and brain function abnormalities. We investigated whether abnormal cerebral blood flow (CBF) patterns exists in T2DM patients and possible relationships between aberrant CBF and cognitive performance. Furthermore, we examined the influence of hypertension on CBF alterations in T2DM patients. T2DM patients (n = 38) and non-T2DM subjects (n = 40) were recruited from clinics, hospitals, and normal community health screenings. Cerebral blood flow images were collected and analyzed using arterial spin labeling perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between T2DM patients and non-T2DM controls were detected via 1-way ANOVA. The interaction effects between hypertension and T2DM for CBF alterations were also examined. Correlation analyses illustrated the association between CBF values and cognitive performance and between CBF and blood pressure. Compared with non-T2DM controls, T2DM patients exhibited decreased CBF, primarily in the visual area and the default mode network (DMN); decreased CBF in these regions was correlated with cognitive performance. There was a significant interaction effect between hypertension and diabetes for CBF in the precuneus and the middle occipital gyrus. Additionally, blood pressure correlated negatively with CBF in T2DM patients.T2DM patients exhibited reduced CBF in the visual area and DMN. Hypertension may facilitate a CBF decrease in the setting of diabetes. T2DM patients may benefit from blood pressure control to maintain their brain perfusion through CBF preservation.

  6. Characterization and biocompatibility of glucan: a safe food additive from probiotic Lactobacillus plantarum DM5.

    Science.gov (United States)

    Das, Deeplina; Goyal, Arun

    2014-03-15

    Exopolysaccharide produced by lactic acid bacteria are the subject of an increasing number of studies for their potential applications in the food industry as stabilizing, bio-thickening and immunostimulating agents. In this regard, the authors isolated an exopolysaccharide producing probiotic lactic acid bacterium from fermented beverage Marcha of north eastern Himalayas. The isolate Lactobacillus plantarum DM5 showed extracellular glucansucrase activity of 0.48 U mg⁻¹ by synthesizing natural exopolysaccharide glucan (1.87 mg mL⁻¹) from sucrose. Zymogram analysis of purified enzyme confirms the presence of glucosyltransferase of approximately 148 kDa with optimal activity of 18.7 U mg⁻¹ at 30 °C and pH 5.4. The exopolysaccharide was purified by gel permeation chromatography and had an average molecular weight of 1.11 × 10⁶ Da. Acid hydrolysis and structural characterization of exopolysaccharide revealed that it was composed of d-glucose residues, containing 86.5% of α-(1→6) and 13.5% of α-(1→3) linkages. Rheological study exhibited a shear thinning effect of glucan appropriate for food additives. A cytotoxicity test of glucan on human embryonic kidney 293 (HEK 293) and human cervical cancer (HeLa) cell lines revealed its nontoxic biocompatible nature. This is the first report on the structure and biocompatibility of homopolysaccharide α-D-glucan (dextran) from probiotic Lactobacillus plantarum strain and its unique physical and rheological properties that facilitate its application in the food industry as viscosifying and gelling agent. © 2013 Society of Chemical Industry.

  7. THE DISTRIBUTION AND CHEMISTRY OF H{sub 2}CO IN THE DM TAU PROTOPLANETARY DISK

    Energy Technology Data Exchange (ETDEWEB)

    Loomis, Ryan A.; Öberg, Karin I.; Guzman, Viviana V. [Department of Astronomy, Harvard University, Cambridge, MA 02138 (United States); Cleeves, L. Ilsedore [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States); Andrews, Sean M., E-mail: rloomis@cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2015-08-20

    H{sub 2}CO ice on dust grains is an important precursor of complex organic molecules (COMs). H{sub 2}CO gas can be readily observed in protoplanetary disks and may be used to trace COM chemistry. However, its utility as a COM probe is currently limited by a lack of constraints on the relative contributions of two different formation pathways: on icy grain surfaces and in the gas phase. We use archival Atacama Large (sub-)Millimeter Array observations of the resolved distribution of H{sub 2}CO emission in the disk around the young low-mass star DM Tau to assess the relative importance of these formation routes. The observed H{sub 2}CO emission has a centrally peaked and radially broad brightness profile (extending out to 500 AU). We compare these observations with disk chemistry models with and without grain-surface formation reactions and find that both gas and grain-surface chemistry are necessary to explain the spatial distribution of the emission. Gas-phase H{sub 2}CO production is responsible for the observed central peak, while grain-surface chemistry is required to reproduce the emission exterior to the CO snow line (where H{sub 2}CO mainly forms through the hydrogenation of CO ice before being non-thermally desorbed). These observations demonstrate that both gas and grain-surface pathways contribute to the observed H{sub 2}CO in disks and that their relative contributions depend strongly on distance from the host star.

  8. A Widespread, Clumpy Starburst in the Isolated Ongoing Dwarf Galaxy Merger dm1647+21

    Science.gov (United States)

    Privon, G. C.; Stierwalt, S.; Patton, D. R.; Besla, G.; Pearson, S.; Putman, M.; Johnson, K. E.; Kallivayalil, N.; Liss, S.; Titans, TiNy

    2017-09-01

    Interactions between pairs of isolated dwarf galaxies provide a critical window into low-mass hierarchical, gas-dominated galaxy assembly and the build-up of stellar mass in low-metallicity systems. We present the first Very Large Telescope/Multi Unit Spectroscopic Explorer (VLT/MUSE) optical integral field unit (IFU) observations of the interacting dwarf pair dm1647+21 selected from the TiNy Titans survey. The Hα emission is widespread and corresponds to a total unobscured star formation rate (SFR) of 0.44 M ⊙ yr‑1, which is 2.7 times higher than the SFR inferred from Sloan Digital Sky Survey (SDSS) data. The implied specific SFR (sSFR) for the system is elevated by more than an order of magnitude above non-interacting dwarfs in the same mass range. This increase is dominated by the lower-mass galaxy, which has a sSFR enhancement of >50. Examining the spatially resolved maps of classic optical line diagnostics, we find that the interstellar medium (ISM) excitation can be fully explained by star formation. The velocity field of the ionized gas is not consistent with simple rotation. Dynamical simulations indicate that the irregular velocity field and the stellar structure is consistent with the identification of this system as an ongoing interaction between two dwarf galaxies. The widespread, clumpy enhancements in the star formation in this system point to important differences in the effect of mergers on dwarf galaxies, compared to massive galaxies; rather than the funneling of gas to the nucleus and giving rise to a nuclear starburst, starbursts in low-mass galaxy mergers may be triggered by large-scale ISM compression, and thus may be more distributed.

  9. HLA-DM Polymorphism and Risk of Trichloroethylene Induced Medicamentosa-like Dermatitis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To establish the association between genetic polymorphisms of HLA-DMA and HLA-DMB and risk of developing trichloroethylene-induced medicamentosa-like dermatitis (TIMLD). Methods Sixty-one cases were medically confirmed to have been affected with TIMLD and 60 controls were selected from exposed workers who were free from TIMLD.The TIMLD cases and controls were similar in terms of age, sex, and duration of exposure. DNA was extracted both from the TIMLD cases and controls, HLA-DMA and HLA-DMB loci were amplified by using Touchdown PCR, and the alleles and genotypes were confirmed by restriction fragment length polymorphism (RFLP) and direct sequencing. Finally, the frequencies of HLA-DMA and HLA-DMB variants were compared between the two groups. Results The results showed that the frequency of HLA-DMA*0101 and HLA-DMB*0103 alleles was significantly increased in TIMLD patients than in controls (71.3% vs. 55.0% for HLA-DMA*0101; P<0.05) (11.5% vs. 3.3% for HLA-DMB*0103; P<0.05). In addition, the frequency of HLA-DMA*0102-*0102 homozygous genotype was also significantly higher in the controls than in the patients (25.0% vs.8.2%, P<0.05), whereas the frequency of heterozygous HLA-DMB *0101-*0102 genotype was lower in the patients in comparison with the controls. Conclusion The polymorphisms of HLA-DM may be associated with the susceptibility to TIMLD.

  10. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model

    Science.gov (United States)

    Elevations of plasma concentrations of branched-chain amino acids (BCAAs) are observed in human insulin resistance and type 2 diabetes mellitus (T2DM); however, there has been some controversy with respect to the passive or causative nature of the BCAA phenotype. Using untargeted metabolomics, plasm...

  11. Detection of H2D+: Measuring the Midplane Degree of Ionization in the Disks of DM Tauri and TW Hydrae

    NARCIS (Netherlands)

    Ceccarelli, C.; Dominik, C.; Lefloch, B.; Caselli, P.; Caux, E.

    2004-01-01

    We report the first detection of the ground transition of the ortho-H2D+ molecule toward one disk source, DM Tau, a tentative detection toward TW Hya, and an upper limit toward LkCa 15. The three observed sources possess young gas-rich disks with large CO depletion factors. We argue that the observe

  12. Simplified DM models with the full SM gauge symmetry : the case of $t$-channel colored scalar mediators

    CERN Document Server

    Ko, P; Park, Myeonghun; Yokoya, Hiroshi

    2016-01-01

    The general strategy for dark matter (DM) searches at colliders currently relies on simplified models. In this paper, we propose a new $t$-channel UV-complete simplified model that improves the existing simplified DM models in two important respects: (i) we impose the full SM gauge symmetry including the fact that the left-handed and the right-handed fermions have two independent mediators with two independent couplings, and (ii) we include the renormalization group evolution when we derive the effective Lagrangian for DM-nucleon scattering from the underlying UV complete models by integrating out the $t$-channel mediators. The first improvement will introduce a few more new parameters compared with the existing simplified DM models. In this study we look at the effect this broader set of free parameters has on direct detection and the mono-$X$ + MET ($X$=jet,$W,Z$) signatures at 13 TeV LHC while maintaining gauge invariance of the simplified model under the full SM gauge group. We find that the direct detect...

  13. Prescription Pattern of Antihypertensive Agents in T2DM Patients Visiting Tertiary Care Centre in North India

    Directory of Open Access Journals (Sweden)

    Ethiraj Dhanaraj

    2012-01-01

    Full Text Available Background. Hypertension management is of a paramount importance in diabetic patients for cardiovascular risk reduction. Aim. To evaluate prescribing pattern of antihypertensive in T2DM (type 2 diabetes patients and compare with existing recent guidelines. Methods. A cross-sectional study involving evaluation of all T2DM patients referred to endocrinology unit at tertiary care centre for hypertension, comorbid complications, and recording prescription. Utilization of 5 different antihypertensive drug classes was compared for all patients receiving 1, 2, 3, 4, or more drugs. Logistical regression was used to assess likelihood of prescription of drugs and/or therapy for specific conditions mentioned in the guidelines. Results. Out of 1358, T2DM enrolled patients 1186 (87% had hypertension (males 52%, females 48%. The median duration (IQ of hypertension diabetics was 4 (1–10 years. A total of 25% patients had controlled BP and 75% with uncontrolled blood pressure (13% isolated systolic hypertension, 6% isolated diastolic hypertension, and 55% both elevated. Overall, ACE inhibitors (ACEIs were prescribed the highest (59% followed by angiotensin receptor blockers (ARBs (52%, calcium channel blockers (CCBs (29%, diuretics (27%, and beta-blockers (14%. Overall, 55% of T2DM patients were on polytherapy, 41% on monotherapy, and 4% had no antihypertensive treatment. Polytherapy was more predominant with age, duration of diabetes, duration of hypertension, and comorbid complications. Conclusion. Although prescribing pattern of antihypertensive showed adherence to existing evidence-based guidelines, higher proportion of uncontrolled hypertensive patients was found.

  14. Promising Medicated Diet

    Institute of Scientific and Technical Information of China (English)

    Yang Wei

    2009-01-01

    @@ The founding conference of World Federation of Chinese Medicine Societies-Special Committee of Medicated Diet & Dietotherapy(WFCMS-SCMDAD).and the first world medicated diet and life nurturing academic seminar was held in the Great Hall of the People.Beijing,China,on August 11.A total of 400 experts and professors on medicated diet and life nurturing from 17 countries and regions including Japan,ROK,U.S.,Canada,U.K.,ect.Honorary President Professor Cai Guangxian delivered a welcoming speech to declare the organization's found.

  15. [Breastfeeding and vegan diet].

    Science.gov (United States)

    Wagnon, J; Cagnard, B; Bridoux-Henno, L; Tourtelier, Y; Grall, J-Y; Dabadie, A

    2005-10-01

    Vegan diet in lactating women can induce vitamin B12 deficiency for their children with risk of an impaired neurological development. A 9.5-month-old girl presented with impaired growth and severe hypotonia. She had a macrocytic anemia secondary to vitamin B12 deficiency. MRI showed cerebral atrophy. She was exclusively breastfed. Her mother was also vitamin B12 deficient, secondary to a vegan diet. She had a macrocytic anemia when discharged from the maternity. Vegan diet is a totally inadequate regimen for pregnant and lactating women, especially for their children. Prevention is based on screening, information and vitamin supplementation.

  16. Mesquite pod meal in sheep diet: intake, apparent digestibility of nutrients and nitrogen balance

    Directory of Open Access Journals (Sweden)

    Edileusa de Jesus do Santos

    2015-02-01

    Full Text Available Eight Santa Ines sheep were assigned to two 4 x 4 Latin squares, to evaluate the effects of replacing elephant grass silage with different levels of mesquite pod meal (MDM (15, 30 and 45% DM on intake, apparent digestibility of dry matter (DM, organic matter (OM, crude protein (CP, ether extract (EE, acid detergent fiber (ADF, neutral detergent fiber (NDF, total carbohydrates (TC and non-fiber carbohydrates (NFC and the nitrogen balance. There was a linear increase (p < 0.05 in the intake of DM, OM, CP, ADF, NDF, NFC and TC according to the addition of MPM to the diet. The digestibility of DM, OM and CP increased (p < 0.05 with the addition of MDM. We observed a positive linear effect (p < 0.05 for the nitrogen intake. The addition of mesquite pod meal up to 45% increased the intake of DM, NDF, ADF, CP, OM, NFC and TC but reduced the digestibility of EE and NDF. MPM at 30 and 45% propitiated a positive nitrogen balance.

  17. Effects of canagliflozin on weight loss in high-fat diet-induced obese mice

    OpenAIRE

    Ji, Wenjun; Zhao, Mei; Wang, Meng; Yan, Wenhui; Liu, Yuan; Ren, Shuting; Lu, Jun; Wang, Bing; Chen, Lina

    2017-01-01

    Canagliflozin, an inhibitor of sodium glucose co-transporter (SGLT) 2, has been shown to reduce body weight during the treatment of type 2 diabetes mellitus (T2DM). In this study, we sought to determine the role of canagliflozin in body weight loss and liver injury in obesity. C57BL/6J mice were fed a high-fat diet to simulate diet-induced obesity (DIO). Canagliflozin (15 and 60 mg/kg) was administered to DIO mice for 4 weeks. Orlistat (10 mg/kg) was used as a positive control. The body weigh...

  18. Feeding behavior of dairy cows in feedlot and fed on crude glycerin levels in the diet

    OpenAIRE

    Meneses,Murilo de Almeida; Silva,Fabiano Ferreira da; Schio, Alex Resende; Silva,Robério Rodrigues; Souza,Dicastro Dias de; Porto Junior,Antônio Ferraz

    2014-01-01

    Current experiment evaluated the inclusion effect of crude glycerin levels in the diet on the feeding behavior of confined dairy cows. Fifteen crossbred Holstein x Zebu cows were used, divided into three 5 x 5 Latin squares, with treatments: control (no addition of glycerin) and inclusion of 50, 100, 150 and 200 g crude glycerin per kg of dry matter (DM) in the diet. The animals were subjected to five visual assessments of feeding behavior for 24 hours in each period. Linear increase on feedi...

  19. [Quality of carbohydrates in the diet and their effect on metabolic control of type 2 diabetes].

    Science.gov (United States)

    Pincheira, Daniela; Morgado, Romina; Alviña, Marcela; Vega, Claudia

    2014-12-01

    The objective of this study was to determine the relationship between the parameters of metabolic control and quality of carbohydrates (CHO) of the diet in individuals with type 2 diabetes, controlled with diet and/or Metformin. In 108 men and women aged between 18 and 60 years, glycosylated hemoglobin A (HbA1c) between 6% and 10%, without sulfonylureas or insulin theraphy; were examined through two separate surveys of 24-hour recall. The CHO intake, GI, GL of diet was analyzed. Values of HbA1c were collected from medical records. Data was tabulated in SPSS version 17 software. The Pearson correlation test was used to analyze the degree of association between variables, considering significant at p diet and HbA1c levels in the individuals. In conclusion the study showed that the quality of CHO, mainly GI, are strongly associated with metabolic control of DM 2.

  20. Lifestyle measures for primary prevention of T2 Diabetes Mellitus (T2DM

    Directory of Open Access Journals (Sweden)

    M S A Mansur Ahmed

    2014-12-01

    Full Text Available Worldwide, the number of adults with diabetes was 285 million in 2010 and it will be 439 million in the year 2030. Although the genes we inherit may influence the development of type 2 diabetes, they take a back seat to behavioral and lifestyle factors. Data from the Nurses’ Health Study suggest that 90 percent of type 2 diabetes in women can be attributed to five such factors: excess weight, lack of exercise, a less-than-healthy diet, smoking, and abstaining from alcohol. From this data it can be said that up to 90 percent of diabetes prevention is possible with behavioral and lifestyle factors intervention. This intervention should be given to the people through primary prevention. The purpose of primary prevention is to limit the number of people who develop a disease by controlling causes and risk factors for the disease.

  1. Rumen degradability characteristics of normal maize stover and silage, and quality protein maize silage-based diets offered to cows.

    Science.gov (United States)

    Tamir, Berhan; Gebrehawariat, Ephrem; Tegegne, Azage; Kortu, Mohammed Y

    2012-10-01

    Rumen degradability characteristics of dry matter (DM), organic matter (OM) and crude protein (CP) of normal maize (NM) stover (T1)-, NM silage (T2)- and quality protein maize (QPM) silage (T3)-based diets were studied using three rumen-fistulated Boran × Friesian non-lactating cows (371 ± 32.00 kg) in 3 × 3 Latin Square Design. Cows were supplemented with a similar concentrate mix. In sacco degradability of DM and OM indicated that the (a) values of DM (128) and OM (114) for NM stover were lower (P silage (268 and 253) and for QPM silage (323 and 303), respectively. The (a) value for CP was lower (P silage (286) than for NM stover (404) and NM silage (326). The (b) values of DM in NM stover (597) and NM silage (535) were higher (P silage (499). The (b) value of CP in NM stover (372) was lower (P silage (655) and in QPM silage (608). Rate of degradation of OM in NM stover and NM silage, each with 0.03, was faster (P silage (0.02). Moreover, QPM silage had higher potentially degradable fraction for DM (821) (P silage was higher (P silage (170 mg/l). The average rumen pH (6.1) in cows fed QPM silage was lowest (P silage. The concentration of total volatile fatty acids (116 mmol/l) in the rumen of cows incubated with QPM silage was higher (P silage (110 mmol/l). It was concluded that QPM silage-based diet was superior in DM and OM degradability, and had higher ammonia and VFA concentration than NM stover-based diet. No differences have been observed in all parameters measured between QPM and NM silages.

  2. Low-fiber diet

    Science.gov (United States)

    ... slow your bowel movements. This helps decrease diarrhea, gas, and bloating. Your doctor may recommend that you follow a low-fiber diet when you have a flare-up of: Irritable bowel syndrome Diverticulitis Crohn disease ...

  3. Diet and Exercise

    Science.gov (United States)

    ... Types Risk Factors Prevention & Early Detection Diet And Exercise Transplant recipients need to be aware of the ... help arrange for counseling and other support services. Exercise After a Transplant Most people are weak after ...

  4. Diet and cancer

    Science.gov (United States)

    Fiber and cancer; Cancer and fiber; Nitrates and cancer; Cancer and nitrates ... DIET AND BREAST CANCER The link between nutrition and breast cancer has been well studied. To reduce risk of breast cancer the American ...

  5. Dieting and Gallstones

    Science.gov (United States)

    ... Walking: A Step in the Right Direction Dieting & Gallstones Introduction According to estimates, as many as 20 ... prevent this very common health problem. What are gallstones? Gallstones are hard crystals that may form in ...

  6. Sea Lion Diet Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — California sea lions pup and breed at four of the nine Channel Islands in southern California. Since 1981, SWFSC MMTD has been conducting a diet study of sea lions...

  7. Diets that Work

    Science.gov (United States)

    ... non-vegetarians. A vegetarian diet can help fight heart disease and high blood pressure. Sample Dinner Menus Vegetarian Spaghetti with Mushroom-Tomato-Asiago Cheese Sauce Steamed Green Beans with Pine Nuts Fruit Salad Vegan Roasted Vegetables with Whole ...

  8. Responses of late-lactation cows to forage substitutes in low-forage diets supplemented with by-products.

    Science.gov (United States)

    Hall, M B; Chase, L E

    2014-05-01

    In response to drought-induced forage shortages along with increased corn and soy prices, this study was conducted to evaluate lactation responses of dairy cows to lower-forage diets supplemented with forage substitutes. By-product feeds were used to completely replace corn grain and soybean feeds. Forty-eight late-lactation cows were assigned to 1 of 4 diets using a randomized complete block design with a 2-wk covariate period followed by a 4-wk experimental period. The covariate diet contained corn grain, soybean meal, and 61% forage. Experimental diets contained chopped wheat straw (WS)/sugar beet pulp at 0/12, 3/9, 6/6, or 9/3 percentages of diet dry matter (DM). Corn silage (20%), alfalfa silage (20%), pelleted corn gluten feed (25.5%), distillers grains (8%), whole cottonseed (5%), cane molasses/whey blend (7%), and vitamin and mineral mix with monensin (2.5%) comprised the rest of diet DM. The WS/sugar beet pulp diets averaged 16.5% crude protein, 35% neutral detergent fiber, and 11% starch (DM basis). Cows consuming the experimental diets maintained a 3.5% fat- and protein-corrected milk production (35.2 kg; standard deviation=5.6 kg) that was numerically similar to that measured in the covariate period (35.3 kg; standard deviation=5.0 kg). Intakes of DM and crude protein declined linearly as WS increased, whereas neutral detergent fiber intake increased linearly. Linear increases in time spent ruminating (from 409 to 502 min/d) and eating (from 156 to 223 min/d) were noted as WS inclusion increased. Yields of milk fat and 3.5% fat-and protein-corrected milk did not change as WS increased, but those of protein and lactose declined linearly. Phosphorous intakes were in excess of recommended levels and decreased linearly with increasing WS inclusion. Nutritional model predictions for multiparous cows were closest to actual performance for the National Research Council 2001 model when a metabolizable protein basis was used; primiparous cow performance was

  9. Anti-inflammatory Diets.

    Science.gov (United States)

    Sears, Barry

    2015-01-01

    Chronic disease is driven by inflammation. This article will provide an overview on how the balance of macronutrients and omega-6 and omega-3 fatty acids in the diet can alter the expression of inflammatory genes. In particular, how the balance of the protein to glycemic load of a meal can alter the generation of insulin and glucagon and the how the balance of omega-6 and omega-3 fatty acids can effect eicosanoid formation. Clinical results on the reduction of inflammation following anti-inflammatory diets are discussed as well as the molecular targets of anti-inflammatory nutrition. To overcome silent inflammation requires an anti-inflammatory diet (with omega-3s and polyphenols, in particular those of Maqui). The most important aspect of such an anti-inflammatory diet is the stabilization of insulin and reduced intake of omega-6 fatty acids. The ultimate treatment lies in reestablishing hormonal and genetic balance to generate satiety instead of constant hunger. Anti-inflammatory nutrition, balanced 40:30:30 with caloric restriction, should be considered as a form of gene silencing technology, in particular the silencing of the genes involved in the generation of silent inflammation. To this anti-inflammatory diet foundation supplemental omega-3 fatty acids at the level of 2-3 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day should be added. Finally, a diet rich in colorful, nonstarchy vegetables would contribute adequate amounts of polyphenols to help not only to inhibit nuclear factor (NF)-κB (primary molecular target of inflammation) but also activate AMP kinase. Understanding the impact of an anti-inflammatory diet on silent inflammation can elevate the diet from simply a source of calories to being on the cutting edge of gene-silencing technology.

  10. Effect of Transtheoretical Model on Diet Control Compliance of the Elderly With Type 2 Diabetes%跨理论模式干预对老年2型糖尿病患者饮食控制依从性的影响研究

    Institute of Scientific and Technical Information of China (English)

    张晓义; 顾海云; 黄燕华; 耿桂灵

    2016-01-01

    Objective To investigate the effect of transtheoretical model on diet control compliance of the elderly with type 2 diabetes(T2DM),and to provide the practical basis and implementation method for the development and improvement of diabetic health education plan. Methods 159 hospitalized T2DM patients in Department of Endocrinology,Affiliated Hospital of Nantong University from March to September in 2014 were selected,and numbering them according to their order of receiving treatment,the ones with odd number were divided into intervention group(n = 80),and those with even number in the control group(n = 79),and the patients were not aware of the group in which they were located. Before the intervention,constructing archives and performing the questionnaire of diet control compliance for all the patients. Patients in the control group applied the traditional education mode and participated in the departmental special topic lectures;based on that of the control group,with transtheoretical model,according to the behavioral changing stage of diet control that patients in,one - to - one individualized intervention targeting at the problems of diet control was conducted. After discharging from hospital,both groups were given telephone follow - up,1 time/ month,for 6 months. The diet control compliance,behavioral changing stages of diet control and clinical indicators of diabetes patients in the two groups before and after the intervention were compared. Results There was no significant difference in the scores of diet control knowledge and diet therapy compliance between the two groups before intervention(P > 0. 05);there were significant differences in scores of diet control knowledge and diet therapy compliance between two groups after intervention(P 0. 05);there was significant difference in the behavioral changing stages of diet control between the two groups after intervention(P 0. 05);there were significant differences in BMI,SBP,FPG,2 hPG,HbA1c ,TG between two

  11. Molecular, Physiological, and Motor Performance Defects in DMSXL Mice Carrying >1,000 CTG Repeats from the Human DM1 Locus

    OpenAIRE

    Aline Huguet; Fadia Medja; Annie Nicole; Alban Vignaud; Céline Guiraud-Dogan; Arnaud Ferry; Valérie Decostre; Jean-Yves Hogrel; Friedrich Metzger; Andreas Hoeflich; Martin Baraibar; Mário Gomes-Pereira; Jack Puymirat; Guillaume Bassez; Denis Furling

    2012-01-01

    Myotonic dystrophy type 1 (DM1) is caused by an unstable CTG repeat expansion in the 3'UTR of the DM protein kinase (DMPK) gene. DMPK transcripts carrying CUG expansions form nuclear foci and affect splicing regulation of various RNA transcripts. Furthermore, bidirectional transcription over the DMPK gene and non-conventional RNA translation of repeated transcripts have been described in DM1. It is clear now that this disease may involve multiple pathogenic pathways including changes in gene ...

  12. Specific Carbohydrate Diet: Does It Work?

    Science.gov (United States)

    ... Specific Carbohydrate Diet (SCD) Go Back The Specific Carbohydrate Diet (SCD) Email Print + Share There is no ... diet that has received attention is the Specific Carbohydrate Diet. This diet limits poorly digestible carbohydrates to ...

  13. Diet and acne.

    Science.gov (United States)

    Bowe, Whitney P; Joshi, Smita S; Shalita, Alan R

    2010-07-01

    Historically, the relationship between diet and acne has been highly controversial. Before the 1960s, certain foods were thought to exacerbate acne. However, subsequent studies dispelled these alleged associations as myth for almost half a century. Several studies during the last decade have prompted dermatologists to revisit the potential link between diet and acne. This article critically reviews the literature and discusses how dermatologists might address diet when counseling patients with acne. Dermatologists can no longer dismiss the association between diet and acne. Compelling evidence exists that high glycemic load diets may exacerbate acne. Dairy ingestion appears to be weakly associated with acne, and the roles of omega-3 fatty acids, antioxidants, zinc, vitamin A, and dietary fiber remain to be elucidated. This study was limited by the lack of randomized controlled trials in the literature. We hope that this review will encourage others to explore the effects of diet on acne. Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  14. Diet-Related Knowledge and Physical Activity in a Large Cohort of Insulin-Treated Type 2 Diabetes Patients: PROGENS ARENA Study

    Directory of Open Access Journals (Sweden)

    Tomasz Klupa

    2016-01-01

    Full Text Available There is no doubt that behavioral intervention is crucial for type 2 diabetes mellitus (T2DM prevention and management. We aimed to estimate dietary habits and diet-oriented knowledge as well as the level of physical activity in 2500 insulin-treated Polish type 2 diabetes mellitus (T2DM patients (55.4% women. The mean age of the study participants was 64.9 ± 9.3 years, mean BMI was 31.4 kg/m2 ± 4.5, mean diabetes duration was 12.4 ± 6.9 years, and mean baseline HbA1c was 8.5%  ± 1.2. At the study onset, all the patients completed a questionnaire concerning health-oriented behavior. Results showed a significant lack of diet-related knowledge. For example, only 37.5% recognized that buckwheat contains carbohydrates; the percentage of correct answers in questions about fruit drinks and pasta was 56.4% and 61.2%, respectively. As for the physical activity, only 57.4% of examined T2DM patients declared any form of deliberate physical activity. To conclude, the cohort of poorly controlled insulin-treated T2DM patients studied by us is characterized by insufficient diet-related knowledge and by a very low level of physical activity. Further studies on other populations of insulin-treated T2DM patients are required to confirm these findings.

  15. Diet-Related Knowledge and Physical Activity in a Large Cohort of Insulin-Treated Type 2 Diabetes Patients: PROGENS ARENA Study

    Science.gov (United States)

    Możdżan, Michał; Kokoszka-Paszkot, Janina; Kubik, Magdalena; Masierek, Małgorzata; Czerwińska, Margerita; Małecki, Maciej T.

    2016-01-01

    There is no doubt that behavioral intervention is crucial for type 2 diabetes mellitus (T2DM) prevention and management. We aimed to estimate dietary habits and diet-oriented knowledge as well as the level of physical activity in 2500 insulin-treated Polish type 2 diabetes mellitus (T2DM) patients (55.4% women). The mean age of the study participants was 64.9 ± 9.3 years, mean BMI was 31.4 kg/m2 ± 4.5, mean diabetes duration was 12.4 ± 6.9 years, and mean baseline HbA1c was 8.5%  ± 1.2. At the study onset, all the patients completed a questionnaire concerning health-oriented behavior. Results showed a significant lack of diet-related knowledge. For example, only 37.5% recognized that buckwheat contains carbohydrates; the percentage of correct answers in questions about fruit drinks and pasta was 56.4% and 61.2%, respectively. As for the physical activity, only 57.4% of examined T2DM patients declared any form of deliberate physical activity. To conclude, the cohort of poorly controlled insulin-treated T2DM patients studied by us is characterized by insufficient diet-related knowledge and by a very low level of physical activity. Further studies on other populations of insulin-treated T2DM patients are required to confirm these findings. PMID:27703476

  16. Replacement corn for jackfruit silage in diets for feedlot lambs

    Directory of Open Access Journals (Sweden)

    José Augusto Gomes Azevêdo

    2015-06-01

    Full Text Available The objective was to evaluate the effects of replacement corn by jackfruit silage on intake, coefficient of apparent digestibility and performance in diets for feedlot confined lambs. Santa Inês crossbred castrated male lambs were used, in the completely randomized design. The replacement levels were 0. 333. 666. 1000 g kg-1 in dry matter (DM of corn as the concentrate component. The intake DM, crude protein (CP (g day-1, neutral detergent fiber (NDF in g kg-1 and g kg-1 body weight (BW increased linearly with replacement. The intake of organic matter (OM, ethereal extract (EE, total carbohydrates (TC and non-fiber carbohydrates (NFC decreased linearly, while for total digestible nutrients (TDN quadratic behavior with replacement. The coefficients of apparent digestibility of OM, TC and NFC decreased linearly with replacement, while the coefficient of digestibility of CP and TDN showed quadratic behavior with replacement. The BW and average daily gain decreased linearly with the replacement of corn for jackfruit silage. The jackfruit silage can be used to replace corn in diets of lambs and their use is dependent on economic factors, the availability of fruit and purpose of animal productivity to be reached

  17. Education

    Science.gov (United States)

    2001-01-01

    method for the delivery of educational services. Social Support Parental involvement in the education process is critical for improving...student performance as parental involvement in their children’s education.” 28

  18. Comparative study on pharmacological effects of DM-phencynonate hydrochloride and its optical isomers

    Institute of Scientific and Technical Information of China (English)

    Li-yun WANG; Jian-quan ZHENG; Yun WANG; Bo-hua ZHONG; Jin-xiu RUAN; Ke-liang LIU

    2005-01-01

    Aim: The 3 -azabicyclo(3,3, 1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (DM-phencynonate hydrochloride, DMCPG) is a demethylated metabolite of 3-methyl-3-azabicyclo(3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (phencynonate hydrochloride, CPG). (±)DMCPG had one chiral center and two enantiomers [R(-) and S(+)DMCPG]. Here we carried out a comparative study of the pharmacological profiles of these optical isomers. Methods: Affinity and relative efficacy were tested using a radioligand-binding assay with muscarinic acetylcholine receptors from the rat cerebral cortex. Pharmacological activity was assessed in three individual experiments: (1) potentiating the effect of a subthreshold hypnotic dose of sodium pentobarbital; (2) inhibiting oxotremorineinduced salivation; and (3) inhibiting the contractile response to carbachol.Results: In the competitive binding assay, R(-)DMCPG (Ki=763.75 nmol/L) was 4-and 2-fold more potent than (±)DMCPG (Ki=3186 nmol/L) and S(+)DMCPG (Ki= 1699 nmol/L) in inhibiting the binding of [3H]QNB. The R(-) and S (+) configurations showed positive cooperation (nH>1) with the muscarinic receptor, whereas (±)DMCPG had a negative cooperation (nH<1) relationship with the muscarinic receptor in a radio-binding assay. Both the R(-) and S(+) configurations could potentiate the effect of sub-threshold hypnotic dose of sodium pentobarbital in a dose-dependent manner (the ED50 values were 2.53 and 18.65 mg/kg, respectively),but (±)DMCPG did not display significant central depressant effects at doses from 10 to 29.15 mg/kg (P>0.05). (±)DMCPG and its optical isomers suppressed the guinea pig ileum contractile response to carbachol. The IC50 values were 7.78×10-9,1.88×10-7, and 1.03× 10-7 nmol/L, respectively. In the anti-salivation study,(±)DMCPG and its enantiomers depressed oxotremorine- induced salivation in a dose-dependent manner, and the order of potency was R(-)DMCPG (ED50=0.44 mg/kg)>(±)DMCPG (ED50

  19. Evolution of Mediterranean diets and cuisine: concepts and definitions.

    Science.gov (United States)

    Radd-Vagenas, Sue; Kouris-Blazos, Antigone; Singh, Maria Fiatarone; Flood, Victoria M

    2017-01-01

    The Mediterranean diet has been demonstrated to provide a range of health benefits in observational and clinical trials and adopted by various dietary guidelines. However, a broad range of definitions exist impeding synthesis across trials. This review aims to provide a historical description of Mediterranean diets, from the ancient to the modern, to inform future educational and diet index tool development representing the 'traditional' Mediterranean diet. Nine databases were searched from inception to July 2015 to identify papers defining the Mediterranean diet. The definition accepted by the United Nations Educational, Scientific and Cultural Organization (UNESCO) was also reviewed. The 'traditional' Mediterranean diet is described as high in unprocessed plant foods (grains, vegetables, fruits, legumes, nuts/seeds and extra virgin olive oil), moderate in fish/shellfish and wine and low in meat, dairy, eggs, animal fats and discretionary foods. Additional elements relating to cuisine and eating habits identified in this review include frequent intake of home cooked meals; use of moist, lower temperature, cooking methods; eating main meals in company; reduced snacking occasions; fasting practice; ownership of a vegetable garden; use of traditional foods and combinations; and napping after the midday meal. Scope exists for future tools to incorporate additional elements of the 'traditional' Mediterranean diet to improve the quality, consistency, and synthesis of ongoing research on the Mediterranean diet.

  20. Effect of type and level of dietary fat on rumen fermentation and performance of dairy cows fed corn silage-based diets.

    Science.gov (United States)

    Onetti, S G; Shaver, R D; McGuire, M A; Grummer, R R

    2001-12-01

    The objective of this study was to investigate the effects of tallow and choice white grease (CWG) fed at 0, 2, and 4% of the diet dry matter (DM) on rumen fermentation and performance of dairy cows when corn silage is the sole forage source. Fifteen midlactation Holstein cows were used in a replicated 5 x 5 Latin square design with 21-d periods. Treatments were 0% fat (control), 2% tallow, 2% CWG, 4% tallow, and 4% CWG (DM basis). The forage:concentrate ratio was 50:50, and diets were formulated to contain 18% crude protein and 32% neutral detergent fiber (DM basis). Cows were allowed ad libitum consumption of diets fed twice daily as total mixed rations. Cows fed supplemental fat had lower DM intake and produced less milk and milk fat than cows fed the control diet. Feeding 4% fat reduced milk production and milk fat yield relative to feeding 2% fat. Treatments had little effect on the concentration of trans-octadecenoic acids in milk fat. Total trans fatty acids were poorly related to changes in milk fat percentage. Ruminal pH and total volatile fatty acids concentration were not affected by supplemental fat. The acetate:propionate ratio, NH3-N, and numbers of protozoa in the rumen were significantly decreased when fat was added to the diets. Source of dietary fat did not affect rumen parameters. There was no treatment effect on in situ corn silage DM and neutral detergent fiber disappearance. Including fat in corn silage-based diets had negative effects on milk production and rumen fermentation regardless of the source or level of supplemental fat.

  1. Attitudes and Barriers to Exercise in Adults with Type 1 Diabetes (T1DM) and How Best to Address Them: A Qualitative Study

    OpenAIRE

    Nadia Lascar; Amy Kennedy; Beverley Hancock; David Jenkins; Andrews, Robert C.; Sheila Greenfield; Parth Narendran

    2014-01-01

    BACKGROUND:Regular physical activity has recognised health benefits for people with T1DM. However a significant proportion of them do not undertake the recommended levels of activity. Whilst questionnaire-based studies have examined barriers to exercise in people with T1DM, a formal qualitative analysis of these barriers has not been undertaken. Our aims were to explore attitudes, barriers and facilitators to exercise in patients with T1DM.METHODOLOGY:A purposeful sample of long standing T1DM...

  2. Estimativa da entalpia reticular de adutos (DM Hm o utilizando-se formas modificadas da equação de Kapustinskii Estimating the value of lattice enthalpy (DM Hm o for adducts by using modified forms of Kapustinskii equation

    Directory of Open Access Journals (Sweden)

    Robson Fernandes de Farias

    1999-04-01

    Full Text Available In this work are presented two modified forms of Kapustinskii equation that could be used to estimate the values of the lattice enthalphies for adducts: DM Hm o=(-n.z+ .z- .10(2/D.(1-d*/D .K and DM Hm o=(-n.z+ .z-.10(2/d.(1-d*/d.K.d. Two new parameters related with steric effects and donor power of the ligands, J anddare introduced. The proposed equations were tested for 49 adducts (mainly from the zinc group halides. The difference between experimental (calorimetric and calculated values (using the proposed equations values are less than 5% for 41 of the tested adducts.

  3. Microbial phytase addition resulted in a greater increase in phosphorus digestibility in dry-fed compared with liquid-fed non-heat-treated wheat-barley-maize diets for pigs

    DEFF Research Database (Denmark)

    Blaabjerg, Karoline; Thomassen, Anne-Marie; Poulsen, Hanne Damgaard

    2015-01-01

    and fed one of four diets for 12 days; 5 days for adaptation and 7 days for total, but separate collection of feces and urine. The basal diet was composed of wheat, barley, maize, soybean meal and no mineral phosphate. Dietary treatments were: basal dry-fed diet (BDD), BDD with microbial phytase (BDD......The objective was to evaluate the effect of microbial phytase (1250 FTU/kg diet with 88% dry matter (DM)) on apparent total tract digestibility (ATTD) of phosphorus (P) in pigs fed a dry or soaked diet. Twenty-four pigs (65±3 kg) from six litters were used. Pigs were housed in metabolism crates......+phy), BDD soaked for 24 h at 20°C before feeding (BDS) and BDS with microbial phytase (BDS+phy). Supplementation of microbial phytase increased ATTD of DM and crude protein (N×6.25) by 2 and 3 percentage units (P

  4. Airplane's video image real-time compression system with TMS320DM642%基于TMS320DM642的机载视频图像实时压缩与处理系统

    Institute of Scientific and Technical Information of China (English)

    陈步康; 王元钦; 周成刚

    2011-01-01

    为了实现机载视频图像的高分辨率实时传输,设计了一种基于TMS320DM642 DSP的机载视频图像实时压缩与处理系统.在分析DM642芯片集成的片内外设特点基础上,设计了基于TMS320DM642 DSP的高集度的视频图像压缩处理平台,并采用基于C64X CPU的软件优化技术对DSP中MPEG-4压缩算法进行了优化,实现了对25帧/秒D1(704×576)或CIF(352×288)分辨率机载视频图像的实时压缩和恒定码率无线传输.%In order to transmit airplane's video image immediately and graphically, this paper designed an airplane's video image real-time MPEG-4 compression system which is based on the newest media processor TMS320DM642. Based on the analysis of the characteristic of the processor,the paper designed the hardware of the system. By using the optimization technique of the software which is based on C64X CPU,the system achieved the optimization of MPEG-4 arithmetic.The experiment shows that the compression system can real-timely compress 25 frames' D1 or CIF images per second according to the command , and transmit it with invariable rate.

  5. 基于TMS320DM6437的掌静脉图像采集系统设计%Design based on TMS320DM6437 palm vein image acquisition system

    Institute of Scientific and Technical Information of China (English)

    苑玮琦; 卢守波

    2015-01-01

    The design and implementation of a TMS320DM6437 to DSP as the core of the palm vein image acquisition system. This system adopts the wavelength of 470nm blue light and wavelength of 850nm near infrared light as the main light source and light source system by contactless palm hand imageacquisition mode, after the hand image acquisition, feature extraction ofinformation for the hand, and then combine the feature recognitionalgorithm for identification. Video processing subsystem of the system mainly consists of CMOS sensor, the TMS320DM6437 (VPSS) and display.Experimental results show that the image acquisition to the system clear,good system stability, fast acquisition speed, meet the requirement ofsystem design.%设计并实现了一种以TMS320DM6437 DSP为核心的掌静脉图像采集系统. 本系统采用了波长为470 nm蓝光和波长为850 nm近红外光作为主要光源,通过手掌和光源系统非接触的方式采集手部图像,采集完手部图像后,提取手部的特征信息,然后结合特征识别算法进行身份识别.该系统主要包括CMOS传感器、TMS320DM6437的视频处理子系统(VPSS)和显示器. 实验结果表明:该系统采集到的图像清晰、系统稳定性好、采集速度快,满足了系统的设计要求.

  6. 基于TMS320DM365的高速网络摄像机的设计%Design of high speed IP camera based on TMS320DM365

    Institute of Scientific and Technical Information of China (English)

    秦臻; 曹剑中

    2011-01-01

    Trditional network canmeras have many problems, such as complex configration, low effciency and high cost The design of high speed IP camera based on TMS320DM365 and embedded linux. Through the research of hardware and software desing of high speed IP camrea based on TMS320DM365. the video data is collected by writing driver program followingng V4L2standard from a front camera The video is compressed based on H.264 standard, then the compressed video data can be transported in 100M network follow the protocols of RTP and RTCP.%针对传统网络摄像杌的结构复杂、效率低下以及昂贵的成本等问题,提出了基于嵌入式Linux和达芬奇技术TMS320DM365处理器平台的高速网络摄像机系统的设计方案.通过对基于TMS320DM365的高速网络摄像机进行硬件软件设计,从前端摄像头采集视频数据,通过Linux操作系统的V4L2编写驱动程序从而实现视频的采集.经H.264压缩算法对视频数据进行处理,最后通过RTP以及RTCP编码后经由100 M网口完成网络传输.

  7. The Use of Ketogenic Diet in Pediatric Patients with Epilepsy

    Science.gov (United States)

    Misiewicz Runyon, Amanda; So, Tsz-Yin

    2012-01-01

    A ketogenic diet is a nonpharmacologic treatment strategy to control refractory epilepsy in children. Although this diet has been used successfully to reduce seizures since the 1920s, the anticonvulsant mechanism of ketosis remains unknown. The initiation of the diet requires an average four-day hospitalization to achieve ketosis in the patient as well as to provide thorough education on diet maintenance for both the patient and the caregivers. A ketogenic diet, consisting of low carbohydrate and high fat intake, leaves little room for additional carbohydrates supplied by medications. Patients on ketogenic diets who exceed their daily carbohydrate limit have the risk of seizure relapse, necessitating hospital readmission to repeat the diet initiation process. These patients are at a high risk for diversion from the diet. Patients admitted to the hospital setting are often initiated on multiple medications, and many hospital systems are not equipped with appropriate monitoring systems to prevent clinicians from introducing medications with high carbohydrate contents. Pharmacists have the resources and the expertise to help identify and prevent the initiation of medications with high carbohydrate content in patients on ketogenic diets. PMID:22970384

  8. An assessment of patient education and self-management in diabetes disease management--two case studies.

    Science.gov (United States)

    Fitzner, Karen; Greenwood, Deborah; Payne, Hildegarde; Thomson, John; Vukovljak, Lana; McCulloch, Amber; Specker, James E

    2008-12-01

    Diabetes affects 7.8% of Americans, nearly 24 million people, and costs $174 billion yearly. People with diabetes benefit from self-management; disease management (DM) programs are effective in managing populations with diabetes. Little has been published on the intersection of diabetes education and DM. Our hypothesis was that diabetes educators and their interventions integrate well with DM and effectively support providers' care delivery. A literature review was conducted for papers published within the past 3 years and identified using the search terms "diabetes educator" and "disease management." Those that primarily addressed community health workers or the primary care/community setting were excluded. Two case studies were conducted to augment the literature. Ten of 30 manuscripts identified in the literature review were applicable and indicate that techniques and interventions based on cognitive theories and behavioral change can be effective when coupled with diabetes DM. Better diabetes self-management through diabetes education encourages participation in DM programs and adherence to recommended care in programs offered by DM organizations or those that are provider based. Improved health outcomes and reduced cost can be achieved by blending diabetes education and DM. Diabetes educators are a critical part of the management team and, with their arsenal of goal setting and behavior change techniques, are an essential component for the success of diabetes DM programs. Additional research needs to be undertaken to identify effective ways to integrate diabetes educators and education into DM and to assess clinical, behavioral, and economic outcomes arising from such programs.

  9. Education

    NARCIS (Netherlands)

    de Valk, H.; Crul, M.; Crul, M.; Heering, L.

    2008-01-01

    Education is of crucial importance in the lives of young adults. Attending school is not only a major part of everyday life, but education is a decisive factor for the future. In literature, educational attainment has been tied to a host of outcomes in adult life. Education is perceived as the key f

  10. Psychological correlates of habitual diet in healthy adults.

    Science.gov (United States)

    Stevenson, Richard J

    2017-01-01

    There are 3 motivations for studying the psychological correlates of habitual diet. First, diet is a major but modifiable cause of morbidity and mortality, and dietary interventions could be improved by knowing the psychological characteristics of consumers of healthy/unhealthy diets. Second, animal studies indicate that diet can impair cognition, stress responsiveness, and affective processing, but it is unclear whether this also happens in humans. Third, certain psychological traits are associated with obesity, but it is not known whether these precede and thus contribute to weight gain. Although many psychological correlates of diet have been identified, the literature is highly dispersed, and there has been no previous comprehensive narrative review. Organized here by psychological domain, studies linking diet with individual differences in perception, cognition, impulsivity, personality, affective processing, mental health, and attitudes, beliefs and values-in healthy adults-are reviewed. Although there is a growing literature on the psychological correlates of fruit/vegetable intake-the core of a healthy diet-consumers of unhealthy diets have characteristics that probably make them less responsive to education-based interventions. Diet may be a causal contributor to depression, and diet is consistently linked to impulsivity and certain personality traits. There are inconsistent and less explored links to perceptual, affective and cognitive processes, with several emerging parallels to the animal literature. Impulsivity and personality traits common to obese individuals also occur in lean consumers of unhealthy diets, suggesting these may contribute to weight gain. Diet-psychology correlates remain understudied even though this could significantly benefit human health. (PsycINFO Database Record

  11. MEAT QUALITY FROM CHAROLAIS BULLS FED DIETS WITH DIFFERENT LEVELS OF CORN SILAGE INCLUSION

    Directory of Open Access Journals (Sweden)

    G. Cozzi

    2007-06-01

    Full Text Available A sample of 6 intensive beef farms was selected according to the feeding plan adopted during the fattening period of Charolais bulls. Two farms did not include any corn silage in the diet (CS0, while corn silage represented 22% of the dietary DM in the second group of 2 farms (CS22, and it raised up to 44% of the dietary DM in the last 2 farms (CS44. Five bulls were randomly selected from each farm to be slaughtered in the same abattoir. Bulls age was similar across treatments but the CS44 bulls had a lower carcass weight (396 kg than the other two treatments (436 and 446 kg for CS0 and CS22, respectively. Carcass fleshiness (SEUROP and fatness scores were not affected by the level of corn silage in the diet. Meat quality was evaluated on a joint sample of the m. Longissimus thoracis, excised from the 5th to the 9th rib of each right half carcass 24 h post-mortem, after an ageing period of 10 d vacuum packaged at 4°C. Meat chemical analysis showed no variations in pH, DM, intramuscular fat and protein content due to the different silage inclusion in the diet. Only the cholesterol content was progressively reduced in the meat of bulls fed increasing quantities of corn silage according to a significant negative linear trend. Meat colour, cooking losses and shear force values were not affected by the diet. Therefore, based on these findings there are no substantial arguments against the use of a large amount of corn silage in the fattening diets of Charolais bulls.

  12. Feed intake, ruminal fermentation, and animal behavior of beef heifers fed forage free diets containing nonforage fiber sources.

    Science.gov (United States)

    Iraira, S P; Ruíz de la Torre, J L; Rodríguez-Prado, M; Calsamiglia, S; Manteca, X; Ferret, A

    2013-08-01

    Eight Simmental heifers (initial BW 313.4 ± 13.2 kg) were randomly assigned to 1 of 4 experimental treatments in a 4 × 4 double Latin square design. The experiment was performed in four 28-d periods. Treatments tested were a control diet in which barley straw (BS) was used as a fiber source and 3 diets where the main difference was the nonforage fiber source used: soybean hulls (SH), beet pulp (BP) in pellets, and whole cottonseed (WCS). All ingredients, except the fiber sources, were ground through a 3-mm screen. Fiber ingredients were incorporated at 10, 17, 17, and 16% (on DM basis) in BS, SH, BP, and WCS, respectively. All diets were offered ad libitum as total mixed ration and designed to be isoenergetic (2.95 Mcal ME/kg DM), isonitrogenous (15% CP, DM basis), and with a NDF content of 20% (on DM basis) although there was a discrepancy between the theoretical and the actual chemical composition of the diets. Particle size separation was performed using the 3-screen Penn State Particle Separator. Animals were allotted in 8 individual roofed concrete pens equipped with a feedbunk and water trough. Intake was recorded over 7 d in the last week of each experimental period. Behavior was recorded for 24-h on d 2 and d 6 of each experimental week using a digital video recording device. A digital color camera was set up in front of each pen. Data recorded, except behavioral activities, were statistically analyzed using the MIXED procedure of SAS. To test treatment effect for each behavioral activity, analysis was performed using the GLIMMIX procedure of SAS. Diets ranked from greater to lesser proportion of particles of less than 1.18 mm as follows: SH, BS, WCS, and BP. Dry matter intake of heifers fed WCS was greater than the remaining treatments (P = 0.049). The greatest average ruminal pH was registered in heifers fed BS (6.4) and BP (6.3) whereas the smallest was recorded in SH diet (5.9), with WCS (6.2) occupying an intermediate position (P = 0.006). Total

  13. Long-term beneficial effect of a 16-week very low calorie diet on pericardial fat in obese type 2 diabetes mellitus patients.

    NARCIS (Netherlands)

    Snel, M.; Jonker, J.T.; Hammer, S.; Kerpershoek, G.; Lamb, H.J.; Meinders, A.E.; Pijl, H.; Roos, A. de; Romijn, J.A.; Smit, J.W.A.; Jazet, I.M.

    2012-01-01

    Pericardial fat accumulation has been associated with an increased cardiovascular risk. A very low calorie diet (VLCD) improves the cardiovascular risk profile in patients with type 2 diabetes mellitus (T2DM), by improving the metabolic profile, heart function, and triglyceride (TG) stores in

  14. The effects of diet and corticosteroid-induced immune suppression during infection by Haemonchus contortus in lambs.

    Science.gov (United States)

    Carvalho, Nadino; das Neves, José Henrique; Nazato, Carina; Louvandini, Helder; Amarante, Alessandro F T

    2015-12-15

    To evaluate the effects of Diet and corticosteroid-induced immune suppression during infection by Haemonchus contortus, 28 lambs were allocated to one of four groups treated as follows: Group Basal Diet - Normal; Group Basal Diet - Immune-Suppressed; Group Supplemented Diet - Normal; and Group Supplemented Diet - Immune-Suppressed. The Basal Diet contained Cynodon dactylon (cv. coast cross) hay with 82 g crude protein (CP)/kg dry matter (DM), which was provided to the lambs in all groups ad libitum. In addition, animals on the Supplemented Diet received daily a commercial concentrate containing 171 g CP/kg DM, which was offered in an amount corresponding to 3% of the animal's live weight. The Immune-Suppressed groups received treatments with the glucocorticoid methylprednisolone sodium succinate (1.33 mg/kg of body weight), administered weekly. All lambs received a single infection with 4000 H. contortus infective larvae (L3) and were euthanised 28 days post-infection. Differences in pH and in the short-chain fatty acid (SCFA) concentrations occurred in rumen as a result of the distinct Diets offered to lambs. Such changes, however, did not have any apparent effect on larvae exsheathment and/or larvae survival inside the rumen, with all groups presenting similar worm burdens. However, animals on the Supplemented Diet presented reductions in worm growth and faecal egg counts. There was a significant effect of the Diet on the IgG levels against total antigens of H. contortus L3 from 7 to 27 days post-infection, with supplemented animals showing higher overall mean values (PDiet; however, only the length of males was significantly affected (P<0.05). In conclusion, the changes caused in the rumen contents by supplementation with concentrate did not impair H. contortus establishment.

  15. 神秘瑰丽的传说FRANCK MULLER 7008 DM T陀飞轮腕表

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    该腕表表盘弃用传统长短针,只以两个FRANCK MULLER专利的圆形转盘来显示时、分功能。7008 DM T陀飞轮腕表采用经典圆形表壳,与面盘上的时分指示盘以及不停舞动的陀飞轮形成完美呼应。

  16. Clarifying the role of the rostral dmPFC/dACC in fear/anxiety: learning, appraisal or expression?

    Directory of Open Access Journals (Sweden)

    Simon Maier

    Full Text Available Recent studies have begun to carve out a specific role for the rostral part of the dorsal medial prefrontal cortex (dmPFC and adjacent dorsal anterior cingulate cortex (dACC in fear/anxiety. Within a novel general framework of dorsal mPFC/ACC areas subserving the appraisal of threat and concomitant expression of fear responses and ventral mPFC/ACC areas subserving fear regulation, the rostral dmPFC/dACC has been proposed to specifically mediate the conscious, negative appraisal of threat situations including, as an extreme variant, catastrophizing. An alternative explanation that has not been conclusively ruled out yet is that the area is involved in fear learning. We tested two different fear expression paradigms in separate fMRI studies (study 1: instructed fear, study 2: testing of Pavlovian conditioned fear with independent groups of healthy adult subjects. In both paradigms the absence of reinforcement precluded conditioning. We demonstrate significant BOLD activation of an identical rostral dmPFC/dACC area. In the Pavlovian paradigm (study 2, the area only activated robustly once prior conditioning had finished. Thus, our data argue against a role of the area in fear learning. We further replicate a repeated observation of a dissociation between peripheral-physiological fear responding and rostral dmPFC/dACC activation, strongly suggesting the area does not directly generate fear responses but rather contributes to appraisal processes. Although we succeeded in preventing extinction of conditioned responding in either paradigm, the data do not allow us to definitively exclude an involvement of the area in fear extinction learning. We discuss the broader implications of this finding for our understanding of mPFC/ACC function in fear and in negative emotion more generally.

  17. HDL-C / apoA-I ] : a multi-vessel cardiometabolic risk marker in women with T2DM.

    Science.gov (United States)

    Hermans, Michel P; Valensi, Paul; Ahn, Sylvie A; Rousseau, Michel F

    2017-09-15

    Although women have higher HDL-C than men, their HDL particles are also prone to become small, dense and dysfunctional in case of T2DM. To assess the vascular risk related to HDLs of different sizes/densities without direct measurement, we adjusted HDL-C to its main apolipoprotein (apoA-I), as [HDL-C/apoA-I]. This ratio estimates HDLs size and provides indices as to their number, cholesterol load, and density. We stratified 280 Caucasian T2DM women according to [HDL-C/apoA-I] quartiles (Q), to determine how it segregates cardiometabolic risk, β-cell function, glycemic control, and vascular complications. Five parameters were derived from combined determination of HDL-C and apoA-I : HDL size; HDL number; cholesterol load per particle (pP); apoA-IpP; and HDL density. An adverse cardiometabolic profile characterized Q-I and Q-II patients, whose HDLs were denser and apoA-I-depleted, whereas Q-III patients had HDLs with characteristics closer to controls. Q-IV patients had HDLs of supernormal size/composition and a more favorable phenotype in terms of fat distribution; insulin sensitivity (64% vs 41%), metabolic syndrome, β-cell function (32% vs 23%); exogenous insulin (44 vs 89 U/day), and glycemic control (HbA1c: 56 vs 61 mmol/mol), associated with lower prevalence of micro-/macrovascular complications: all-cause microangiopathy 47% vs 61%; retinopathy 22% vs 34%; all-cause macroangiopathy 19% vs 31%; and CAD: 6% vs 24% (pHDL-C/apoA-I] can stratify T2DM women according to metabolic phenotype, macrovascular and coronary damage, β-cell function, microangiopathic risk, and retinopathy. This ratio is a versatile and readily available marker of cardiometabolic status and vascular complications in T2DM women. This article is protected by copyright. All rights reserved.

  18. Dry matter and digesta particle size gradients along the goat digestive tract on grass and browse diets.

    Science.gov (United States)

    Clauss, M; Fritz, J; Tschuor, A; Braun, U; Hummel, J; Codron, D

    2017-02-01

    Physical properties of the digesta vary along the ruminant digestive tract. They also vary within the forestomach, leading to varying degrees of rumen contents stratification in 'moose-type' (browsing) and 'cattle-type' (intermediate and grazing) ruminants. We investigated the dry matter concentration (DM) and the mean digesta particle size (MPS) within the forestomach and along the digestive tract in 10 goats fed grass hay or dried browse after a standardized 12-h fast, euthanasia and freezing in the natural position. In all animals, irrespective of diet, DM showed a peak in the omasum and an increase from caecum via colon towards the faeces and a decrease in MPS between the reticulum and the omasum. Both patterns are typical for ruminants in general. In the forestomach, there was little systematic difference between more cranial and more caudal locations ('horizontal stratification'), with the possible exception of large particle segregation in the dorsal rumen blindsac on the grass diet. In contrast, the typical (vertical) contents stratification was evident for DM (with drier contents dorsally) and, to a lower degree, for MPS (with larger particles dorsally). Although evident in both groups, this stratification was more pronounced on the grass diet. The results support the interpretation that differences in rumen contents stratification between ruminants are mainly an effect of species-specific physiology, but can be enhanced due to the diet consumed. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

  19. Ammoniated babassu palm hay in anglo-nubian goat diets

    Directory of Open Access Journals (Sweden)

    Antonia Leidiana Moreira

    Full Text Available ABSTRACT Leaves of babassu may be used in diets for goats under maintenance, however, it is a low-quality roughage due to its high fiber content. The chemical treatment by ammonia causes reduction in the proportion of the cell wall, in addition to providing non-protein nitrogen for the microbial protein synthesis in the rumen. Babassu palm hay ammoniated with 4% urea (BHAU4% was evaluated in this study as a substitute for guinea grass hay in the maintenance diets of goats in terms of intake, digestibility in vivo, and the partitioning of energy and nitrogen compounds. Twenty Anglo-Nubian male goats were used in a randomised block design with four treatments (diets containing 0, 33, 66, or 100% BHAU4% and five replicates (animals/block. The chemical compositions of the feeds, leftovers, faeces, nitrogen and crude energy of the urine were evaluated. In addition, the rumen fluid pH, the rumen N-NH3, and the blood serum urea were evaluated. The digestibility of the dry matter (DM, organic matter (OM, crud protein (CP, neutral detergent fiber (NDFap and detergent acid (ADFap, corrected for ash and protein, declined (P<0.05 0.0939, 0.0722, 0.0953, 0.1113, and 0.2666%, respectively, with the 1% inclusion of babassu palm hay in the diet. A negative linear effect (P<0.05 was observed in the ingested nitrogen (N, excretion of N in the urine, retained N, and N balance, with decreases of 0.15711, 0.0225 and 0.1071 g/day and 0.1388%, respectively, per percentage unit of the babassu palm hay included in the diet. The intake and digestibility of the DM and nutrients are reduced with the inclusion of BHAU4% in maintenance diets for goats, with positive nitrogen balance and stability of the ruminal pH and N-NH3 as well as blood urea, which presented values within the normal physiological range for goats.

  20. Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles.

    Science.gov (United States)

    Balciuniene, Jorune; Bardwell, Vivian J; Zarkower, David

    2006-12-01

    Proteins containing the DM domain, a zinc finger-like DNA binding motif, have been implicated in sexual differentiation in diverse metazoan organisms. Of seven mammalian DM domain genes, only Dmrt1 and Dmrt2 have been functionally analyzed. Here, we report expression analysis and targeted disruption of Dmrt4 (also called DmrtA1) in the mouse. Dmrt4 is widely expressed during embryonic and postnatal development. However, we find that mice homozygous for a putative null mutation in Dmrt4 develop essentially normally, undergo full sexual differentiation in both sexes, and are fertile. We observed two potential mutant phenotypes in Dmrt4 mutant mice. First, ovaries of most mutant females have polyovular follicles, suggesting a role in folliculogenesis. Second, 25% of mutant males consistently exhibited copulatory behavior toward other males. We also tested potential redundancy between Dmrt4 and two other gonadally expressed DM domain genes, Dmrt1 and Dmrt7. We observed no enhancement of gonadal phenotypes in the double mutants, suggesting that these genes function independently in gonadal development.

  1. Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.

    Science.gov (United States)

    Bilioni, Aphrodite; Sánchez-Hernández, David; Callejo, Ainhoa; Gradilla, Ana-Citlali; Ibáñez, Carmen; Mollica, Emanuela; Carmen Rodríguez-Navas, M; Simon, Eléanor; Guerrero, Isabel

    2013-04-15

    Hedgehog can signal both at a short and long-range, and acts as a morphogen during development in various systems. We studied the mechanisms of Hh release and spread using the Drosophila wing imaginal disc as a model system for polarized epithelium. We analyzed the cooperative role of the glypican Dally, the extracellular factor Shifted (Shf, also known as DmWif), and the Immunoglobulin-like (Ig-like) and Fibronectin III (FNNIII) domain-containing transmembrane proteins, Interference hedgehog (Ihog) and its related protein Brother of Ihog (Boi), in the stability, release and spread of Hh. We show that Dally and Boi are required to prevent apical dispersion of Hh; they also aid Hh recycling for its release along the basolateral part of the epithelium to form a long-range gradient. Shf/DmWif on the other hand facilitates Hh movement restrained by Ihog, Boi and Dally, establishing equilibrium between membrane attachment and release of Hh. Furthermore, this protein complex is part of thin filopodia-like structures or cytonemes, suggesting that the interaction between Dally, Ihog, Boi and Shf/DmWif is required for cytoneme-mediated Hh distribution during gradient formation.

  2. Status of ArDM-1t: First observations from operation with a full ton-scale liquid argon target

    CERN Document Server

    Calvo, J; Daniel, M; Degunda, U; Di Luise, S; Epprecht, L; Gendotti, A; Horikawa, S; Knecht, L; Montes, B; Mu, W; Munoz, M; Murphy, S; Natterer, G; Nguyen, K; Nikolics, K; Periale, L; Regenfus, C; Romero, L; Rubbia, A; Santorelli, R; Sergiampietri, F; Sgalaberna, D; Viant, T; Wu, S

    2015-01-01

    ArDM-1t is the first operating ton-scale liquid argon detector for direct search of Dark Matter particles. Developed at CERN as Recognized Experiment RE18, the experiment has been approved in 2010 to be installed in the Spanish underground site LSC (Laboratorio Subterraneo de Canfranc). Under the label of LSC EXP-08-2010 the ArDM detector underwent an intensive period of technical completion and safety approval until the recent filling of the target vessel with almost 2 ton of liquid argon. This report describes the experimental achievements during commissioning of ArDM and the transition into a stage of first physics data taking in single phase operational mode. We present preliminary observations from this run. A first indication for the background discrimination power of LAr detectors at the ton-scale is shown. We present an outlook for completing the detector with the electric drift field and upgrade of the scintillation light readout system with novel detector modules based on SiPMs in order to improve t...

  3. Neutron background at the Canfranc Underground Laboratory and its contribution to the IGEX-DM dark matter experiment

    CERN Document Server

    Carmona, J M; García, E; Irastorza, I G; Luzón, G; Morales, A; Morales, J; De Solorzano, A O; Puimedón, J; Sarsa, M L; Villar, J A

    2004-01-01

    A quantitative study of the neutron environment in the Canfranc Underground Laboratory has been performed. The analysis is based on a complete set of simulations and, particularly, it is focused on the IGEX-DM dark matter experiment. The simulations are compared to the IGEX-DM low energy data obtained with different shielding conditions. The results of the study allow us to conclude, with respect to the IGEX-DM background, that the main neutron population, coming from radioactivity from the surrounding rock, is practically eliminated after the implementation of a suitable neutron shielding. The remaining neutron background (muon-induced neutrons in the shielding and in the rock) is substantially below the present background level thanks to the muon veto system. In addition, the present analysis gives us a further insight on the effect of neutrons in other current and future experiments at the Canfranc Underground Laboratory. The comparison of simulations with the body of data available has allowed to set the ...

  4. The Effect of ‘Locus of Control’ on the Diabetes Mellitus Patients’ Intention in Performing the Dm Control

    Directory of Open Access Journals (Sweden)

    Yusran Haskas

    2016-02-01

    Full Text Available The behavioral control of diabetes mellitus can improve the quality of life through specific behavior planning. In the theory of planned behavior, the intentions are needed to bring up a person's behavior. A person can act on his intentions if he has control over his behavior. To control the behavior, the role of locus of control is required. Therefore, the research was conducted to investigate the effect of locus of control on the intention of diabetes mellitus patients in performing the diabetes mellitus control. This type of research was explanatory research using cross sectional design. The instrument of diabetic locus of control scale was used to collect the data. Consecutive sampling technique was used to obtain 134 samples. The data were analyzed by simple linear regression. The findings showed that 88,1% of respondents tend to have an internal locus of control and 98,6% of respondents have a strong intention to control the DM. Simple linear regression test results indicate that the locus of control significantly affect the diabetic patients’ intention to perform the control (p=0,032. The findings of the effect of locus of control on the intention of DM patients have implications for the need of the provision of information and positive support consistently in order to become a source of a filler control center that initiated the emergence of a strong intention to conduct the DM control.

  5. Performance of the CellaVision ® DM96 system for detecting red blood cell morphologic abnormalities

    Directory of Open Access Journals (Sweden)

    Christopher L Horn

    2015-01-01

    Full Text Available Background: Red blood cell (RBC analysis is a key feature in the evaluation of hematological disorders. The gold standard light microscopy technique has high sensitivity, but is a relativity time-consuming and labor intensive procedure. This study tested the sensitivity and specificity of gold standard light microscopy manual differential to the CellaVision ® DM96 (CCS; CellaVision, Lund, Sweden automated image analysis system, which takes digital images of samples at high magnification and compares these images with an artificial neural network based on a database of cells and preclassified according to RBC morphology. Methods: In this study, 212 abnormal peripheral blood smears within the Calgary Laboratory Services network of hospital laboratories were selected and assessed for 15 different RBC morphologic abnormalities by manual microscopy. The same samples were reassessed as a manual addition from the instrument screen using the CellaVision ® DM96 system with 8 microscope high power fields (×100 objective and a 22 mm ocular. The results of the investigation were then used to calculate the sensitivity and specificity of the CellaVision ® DM96 system in reference to light microscopy. Results: The sensitivity ranged from a low of 33% (RBC agglutination to a high of 100% (sickle cells, stomatocytes. The remainder of the RBC abnormalities tested somewhere between these two extremes. The specificity ranged from 84% (schistocytes to 99.5% (sickle cells, stomatocytes. Conclusions: Our results showed generally high specificities but variable sensitivities for RBC morphologic abnormalities.

  6. Diet supplementation with cinnamon oil, cinnamaldehyde, or monensin does not reduce enteric methane production of dairy cows.

    Science.gov (United States)

    Benchaar, C

    2016-03-01

    This study was conducted to evaluate the effect of dietary addition of cinnamon oil (CIN), cinnamaldehyde (CDH), or monensin (MON) on enteric methane (CH4) emission in dairy cows. Eight multiparous lactating Holstein cows fitted with ruminal cannulas were used in a replicated 4×4 Latin square design (28-day periods). Cows were fed (ad libitum) a total mixed ration ((TMR); 60 : 40 forage : concentrate ratio, on a dry matter (DM) basis) not supplemented (CTL), or supplemented with CIN (50 mg/kg DM intake), CDH (50 mg/kg DM intake), or monensin (24 mg/kg of DM intake). Dry matter intake (DMI), nutrient digestibility, N retention, and milk performance were measured over 6 consecutive days. Ruminal degradability of the basal diet (with no additive) was assessed using in sacco incubations (0, 2, 4, 8, 16, 24, 48, 72 and 96 h). Ruminal fermentation characteristics (pH, volatile fatty acids (VFA), and ammonia (NH3)) and protozoa were determined over 2 days. Enteric CH4 emissions were measured over 6 consecutive days using the sulfur hexafluoride (SF6) tracer gas technique. Adding CIN, CDH or MON to the diet had no effects on DMI, N retention, in sacco ruminal degradation and nutrient digestibility of the diet. Ruminal fermentation characteristics and protozoa numbers were not modified by including the feed additives in the diet. Enteric CH4 emission and CH4 energy losses averaged 491 g/day and 6.59% of gross energy intake, respectively, and were not affected by adding CIN, CDH or MON to the diet. Results of this study indicate that CIN, CDH and MON are not viable CH4 mitigation strategies in dairy cows.

  7. Mediterranean diet, culture and heritage: challenges for a new conception.

    Science.gov (United States)

    Xavier Medina, F

    2009-09-01

    The aim of the present article is to discuss the role of the Mediterranean diet as a part of Human Culture and Intangible Cultural Heritage. Until the present, Mediterranean diet has been observed as a healthy model of medical behaviour. After its proposal as a Cultural Heritage of the Humanity at UNESCO (United Nations Educational, Scientific and Cultural Organization), Mediterranean diet is actually being observed as a part of Mediterranean culture and starting its concept as an equivalent of Mediterranean Cultural Food System or Mediterranean Culinary System. At the candidacy of Mediterranean diet as a World Cultural Intangible Heritage to be presented at UNESCO in 2008, this new conception is making sense. A new point of view that will be capital in the future discussions about the Mediterranean diet, their challenges and their future perspectives.

  8. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation......Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... with vitamins A, C and E and beta-carotene offers no protection against the development of lung cancer. On the contrary, beta-carotene supplementation has, in two major randomised intervention trials, resulted in an increased mortality. Smoking remains the leading cause of lung cancer. The adverse effects...

  9. The New Nordic Diet

    DEFF Research Database (Denmark)

    Micheelsen, Arun

    This PhD project is part of the research programme at the OPUS Research Centre (2009-2013) at the University of Copenhagen. The aim of the Centre is to improve public health in Denmark by developing, testing and disseminating the New Nordic Diet (NND). Combining the gastronomic ideals of the New...... Nordic Cuisine movement with eating habits that accord with Nordic dietary recommendations, the NND is designed to be a healthy, Nordic, seasonal and organic diet that will be acceptable to Danish consumers. This PhD study has four objectives: (i) to explore the acceptance of the NND among Danish......: (iv) to assess which social and cultural factors are likely to impact upon the achievement of the aim of OPUS. The NND concept was found to be well accepted, although some consumers viewed it as being an elitist diet. Also, the taste of the NND was very well accepted. The practical hallenges and time...

  10. Vegetarian diets and children.

    Science.gov (United States)

    Sanders, T A

    1995-08-01

    Although the general health and development of vegan and vegetarian children seem to be normal, there may be subtle differences compared with omnivores. They are at increased risk of iron deficiency, and impaired psychomotor development associated with iron deficiency has been reported in macrobiotic infants. Fortunately, this impairment is not permanent, and follow-up studies have reported higher-than-average intelligence quotients among older macrobiotic children. Several other hazards of vegetarian diets have been identified, including vitamin B12 deficiency, rickets, and a bulky diet that can restrict energy intake in the first few years of life; however, these pitfalls can be avoided easily, and children can be successfully reared on vegetarian diets.

  11. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...... with vitamins A, C and E and beta-carotene offers no protection against the development of lung cancer. On the contrary, beta-carotene supplementation has, in two major randomised intervention trials, resulted in an increased mortality. Smoking remains the leading cause of lung cancer. The adverse effects...

  12. Digestion, growth performance and caecal fermentation in growing rabbits fed diets containing foliage of browse trees

    Directory of Open Access Journals (Sweden)

    S.H. Abu Hafsa

    2016-12-01

    Full Text Available This study aimed to evaluate the effect of feeding dried foliage (leaves and petioles of Acacia saligna, Leucaena leucocephala or Moringa oleifera on the performance, digestibility, N utilisation, caecal fermentation and microbial profiles in New Zealand White (NZW rabbits. One hundred weaned male NZW rabbits weighing 819.2±16.6 g and aged 35±1 d were randomly allocated into 4 groups of 25 rabbits each. Rabbits were fed on pelleted diets containing 70% concentrate mixture and 30% Egyptian berseem (Trifolium alexandrinum hay (Control diet or one of the other 3 experimental diets, where 50% of berseem hay was replaced with A. saligna (AS, L. leucocephala (LL or M. oleifera (MO. Compared to Control diet, decreases in dry matter (DM; P=0.004, organic matter (P=0.028, crude protein (CP; P=0.001, neutral detergent fibre (P=0.033 and acid detergent fibre (P=0.011 digestibility were observed with the AS diet. However, DM and CP digestibility were increased by 3% with the MO diet, and N utilisation was decreased (P<0.05 with AS. Rabbits fed AS and LL diets showed decreased (P=0.001 average daily gain by 39 and 7%, respectively vs. Control. Feed conversion was similar in Control and MO rabbits, whereas rabbits fed AS diet ate up to 45% more feed (P=0.002 than Control rabbits to gain one kg of body weight. Caecal ammonia-N was increased (P=0.002 with LL, while acetic acid was decreased (P=0.001 with AS diet vs. other treatments. Caecal E. coli and Lactobacillus spp. bacteria counts were decreased with MO by about 44 and 51%, respectively, vs. Control. In conclusion, under the study conditions, tree foliage from M. oleifera and L. leucocephala are suitable fibrous ingredients to be included up to 150 g/kg in the diets of growing rabbits, and can safely replace 50% of berseem hay in diets of NZW rabbits without any adverse effect on their growth performance. Foliage from M. oleifera had a better potential as a feed for rabbits than that from L

  13. Performance, carcass characteristics, and ruminal pH of Nellore and Angus young bulls fed a whole shelled corn diet.

    Science.gov (United States)

    Carvalho, J R R; Chizzotti, M L; Schoonmaker, J P; Teixeira, P D; Lopes, R C; Oliveira, C V R; Ladeira, M M

    2016-06-01

    The objectives of this study were to test the interaction of breed (Nellore or Angus) and diet (whole shelled corn [WSC] or ground corn [GC] with silage) on growth performance, carcass characteristics, and ruminal pH of young bulls. Thirty-six bulls (18 Nellore and 18 Angus) with the range in age of 18 to 22 mo and BW of 381 ± 12 kg were used in a completely randomized design experiment with a 2 × 2 factorial arrangement of treatments (2 breeds and 2 diets). Experimental diets (DM basis) included 1) a GC diet containing 30% corn silage and 70% GC- and soybean meal-based concentrate and 2) a WSC diet containing 85% WSC and 15% of a soybean meal- and mineral-based pelleted supplement. An additional 8 bulls were slaughtered at the beginning of the experimental period for determination of initial carcass weight. The treatments were Nellore fed the GC diet, Nellore fed the WSC diet, Angus fed the GC diet, and Angus fed the WSC diet. Greater DMI ( Angus bulls compared with Nellore bulls, regardless of diet. Lower average ruminal pH ( = 0.04), maximum ruminal pH (P = 0.02), and DMI ( Angus breed ( < 0.02) and were greater when bulls were fed the GC diet. The WSC diet without forage may be useful for feedlots because this diet promoted greater G:F than the GC diet, regardless of breed. However, special care must be exercised in feed management during adaptation and throughout the feeding of Nellore animals to avoid digestive disorders and fluctuations in DMI.

  14. Evaluation of nutrient digestibility and fecal characteristics of exotic felids fed horse- or beef-based diets: use of the domestic cat as a model for exotic felids.

    Science.gov (United States)

    Vester, Brittany M; Beloshapka, Alison N; Middelbos, Ingmar S; Burke, Sarah L; Dikeman, Cheryl L; Simmons, Lee G; Swanson, Kelly S

    2010-01-01

    The objective of this study was to determine the effects of feeding commercially available beef- and horse-based diets on nutrient digestibility and fecal characteristics of large captive exotic felids and domestic cats. Four species of large exotic felids including cheetahs, Malayan tigers, jaguars, and Amur tigers, and domestic cats were utilized in a crossover design. Raw meat diets included a beef-based diet (57% protein; 28% fat) and a horse-based diet (51% protein; 30% fat). All cats were acclimated to the diet for 16 days followed by a 4 day collection period, where total feces, including one fresh sample, were collected. All feces were scored on collection. Intake did not differ due to diet, but fecal output was greater when cats consumed the horse-based diet. Total tract apparent dry matter (DM) digestibility was higher (Phorse-based diet. CP digestibility was similar in domestic cats and cheetahs, and greater (Phorse-based diet compared with the beef-based diet. Domestic cats had lower (Phorse-based diet. Fecal total short-chain fatty acid (SCFA), branched-chain fatty acid (BCFA), and butyrate concentrations were higher (P<0.05) when cats consumed the beef-based diet. Our results suggest that the domestic cat serves as an appropriate model for large exotic felid species, but differences among the species exist. Decreased nutrient digestibility by tigers and jaguars should be considered when developing feeding recommendations for these species based on domestic cat data.

  15. Dietary nitrate supplementation reduces methane emission in beef cattle fed sugarcane-based diets.

    Science.gov (United States)

    Hulshof, R B A; Berndt, A; Gerrits, W J J; Dijkstra, J; van Zijderveld, S M; Newbold, J R; Perdok, H B

    2012-07-01

    The objective of this study was to determine the effect of dietary nitrate on methane emission and rumen fermentation parameters in Nellore × Guzera (Bos indicus) beef cattle fed a sugarcane based diet. The experiment was conducted with 16 steers weighing 283 ± 49 kg (mean ± SD), 6 rumen cannulated and 10 intact steers, in a cross-over design. The animals were blocked according to BW and presence or absence of rumen cannula and randomly allocated to either the nitrate diet (22 g nitrate/kg DM) or the control diet made isonitrogenous by the addition of urea. The diets consisted of freshly chopped sugarcane and concentrate (60:40 on DM basis), fed as a mixed ration. A 16-d adaptation period was used to allow the rumen microbes to adapt to dietary nitrate. Methane emission was measured using the sulfur hexafluoride tracer technique. Dry matter intake (P = 0.09) tended to be less when nitrate was present in the diet compared with the control, 6.60 and 7.05 kg/d DMI, respectively. The daily methane production was reduced (P Methane emission per kilogram DMI was 27% less (P methane/kg DMI) than on the control diet (18.2 g methane/kg DMI). Methane losses as a fraction of gross energy intake (GEI) were less (P methane production by 87% of the theoretical potential. The rumen fluid ammonia-nitrogen (NH(3)-N()) concentration was significantly greater (P methane emission in beef cattle fed sugarcane based diet.

  16. Evaluation of silage diets offered to reindeer calves intended for slaughter. I. Feeding of silage and barley from September to March

    Directory of Open Access Journals (Sweden)

    Anna Nilsson

    1996-01-01

    Full Text Available An experiment involving 75 male reindeer calves (mean initial live weight 39.6 kg, SD=3.7 intended for slaughter was undertaken to study the effect of proporrion of barley to silage in the diets on animal performance. The calves were alloted to five groups including one group slaughtered at the start of the experiment in September. The remaining groups were offered diets containing either, 30% (LB, or 60% (HB rolled barley, based on the dry matter (DM content, until slaughter in November (LB and HB or in March (HB. The silage (43% DM was made from the primary growth of a predominantly grass sward preserved as plastic-wrapped big bales. Small amounts of lichens were mixed with the rations during rhe first two weeks of the experiment and the calves adapted well to the experimental diets. However, health problems and deaths occurred on borh rarions after five weeks of feeding. Since the animals fed the LB diet lost live weight and condition the experimental feeding of these calves were interrupted at the slaughter in November. Calves fed the LB diet had significantly lower daily DM intake (P<0.01. They also had lower live weighr gain (not significant, greater losses of carcass weight and fat in the abdominal cavity relative to those offered the HB diet. During the second period of the study the remaining animals offered the HB diet showed no signs of ill-health and increased live weight, carcass weighr, and fat in the abdominal cavity. The results of the presenr experiment indicate that when silage of the investigated quality is fed to reindeer calves rhe proportion of silage should not exceed 40% of the DM.

  17. Effect of niacin supplementation on digestibility, nitrogen utilisation and milk and blood variables in lactating dairy cows fed a diet with a negative rumen nitrogen balance.

    Science.gov (United States)

    Aschemann, Martina; Lebzien, Peter; Hüther, Liane; Döll, Susanne; Südekum, Karl-Heinz; Dänicke, Sven

    2012-06-01

    The aim of the present experiment was to determine if a niacin supplementation of 6 g/d to lactating dairy cow diets can compensate negative effects of a rumen nitrogen balance (RNB) deficit. A total of nine ruminally and duodenally fistulated lactating multiparous German Holstein cows were successively assigned to one of three diets consisting of 10 kg maize silage (dry matter [DM] basis) and 7 kg DM concentrate: Diet RNB- (n = 6) with energy and utilisable crude protein at the duodenum (uCP) according to the average requirement of the animals but with a negative RNB (-0.41 g N/MJ metabolisable energy [ME]); Diet RNB0 (n = 7) with energy, uCP and a RNB (0.08 g N/MJ ME) according to the average requirement of the animals and, finally, Diet NA (n = 5), which was the same diet as RNB-, but supplemented with 6 g niacin/d. Samples of milk were taken on two consecutive days, blood samples were taken on one day pre- and post-feeding and faeces and urine were collected completely over five consecutive days. The negative RNB reduced milk and blood urea content and apparent total tract digestibility of DM, organic matter (OM) and neutral detergent fibre (NDF). Also N excretion with urine, the total N excreted with urine and faeces and the N balance were reduced when the RNB was negative. Supplementation of niacin elevated plasma glucose concentration after feeding and the N balance increased. Supplementing the diet with a negative RNB with niacin led to a more efficient use of dietary N thereby avoiding the negative effects of the negative RNB on the digestibility of DM, OM and NDF.

  18. Poor glycemic control impacts linear and non-linear dynamics of heart rate in DM type 2

    Directory of Open Access Journals (Sweden)

    Daniela Bassi

    2015-08-01

    Full Text Available INTRODUCTION: It is well known that type 2 diabetes mellitus (T2DM produces cardiovascular autonomic neuropathy (CAN, which may affect the cardiac autonomic modulation. However, it is unclear whether the lack of glycemic control in T2DM without CAN could impact negatively on cardiac autonomic modulation. Objective: To evaluate the relationship between glycemic control and cardiac autonomic modulation in individuals with T2DM without CAN. Descriptive, prospective and cross sectional study.METHODS: Forty-nine patients with T2DM (51±7 years were divided into two groups according to glycosylated hemoglobin (HbA1c: G1≤7% and G2>7.0%. Resting heart rate (HR and RR interval (RRi were obtained and calculated by linear (Mean iRR; Mean HR; rMSSD; STD RR; LF; HF; LF/HF, TINN and RR Tri, and non-linear (SD1; SD2; DFα1; DFα2, Shannon entropy; ApEn; SampEn and CD methods of heart rate variability (HRV. Insulin, HOMA-IR, fasting glucose and HbA1c were obtained by blood tests.RESULTS: G2 (HbA1c≤7% showed lower values for the mean of iRR; STD RR; RR Tri, TINN, SD2, CD and higher mean HR when compared with G1 (HbA1c > 7%. Additionally, HbA1c correlated negatively with mean RRi (r=0.28, p=0.044; STD RR (r=0.33, p=0.017; RR Tri (r=-0.35, p=0.013, SD2 (r=-0.39, p=0.004 and positively with mean HR (r=0.28, p=0.045. Finally, fasting glucose correlated negatively with STD RR (r=-0.36, p=0.010; RR Tri (r=-0.36, p=0.010; TINN (r=-0.33, p=0.019 and SD2 (r=-0.42, p=0.002.CONCLUSION: We concluded that poor glycemic control is related to cardiac autonomic modulation indices in individuals with T2DM even if they do not present cardiovascular autonomic neuropathy.

  19. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

    Science.gov (United States)

    Painter, Corrie A.; Negroni, Maria P.; Kellersberger, Katherine A.; Zavala-Ruiz, Zarixia; Evans, James E.; Stern, Lawrence J.

    2011-01-01

    HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM binding affinity, weakened MHC-peptide hydrogen bonding as measured by hydrogen-deuterium exchange mass spectrometry, and increased susceptibility to DM-mediated peptide exchange. Structural analysis revealed a set of concerted conformational alterations at the N-terminal end of the peptide-binding site. These results suggest that interaction with HLA-DM is driven by a conformational change of the MHC II protein in the region of the α-subunit 310 helix and adjacent extended strand region, and provide a model for the mechanism of DM-mediated peptide exchange. PMID:22084083

  20. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.

    Science.gov (United States)

    Painter, Corrie A; Negroni, Maria P; Kellersberger, Katherine A; Zavala-Ruiz, Zarixia; Evans, James E; Stern, Lawrence J

    2011-11-29

    HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM binding affinity, weakened MHC-peptide hydrogen bonding as measured by hydrogen-deuterium exchange mass spectrometry, and increased susceptibility to DM-mediated peptide exchange. Structural analysis revealed a set of concerted conformational alterations at the N-terminal end of the peptide-binding site. These results suggest that interaction with HLA-DM is driven by a conformational change of the MHC II protein in the region of the α-subunit 3(10) helix and adjacent extended strand region, and provide a model for the mechanism of DM-mediated peptide exchange.