Gaussian free fields at the integer quantum Hall plateau transition

Energy Technology Data Exchange (ETDEWEB)

Bondesan, R., E-mail: roberto.bondesan@phys.ox.ac.uk [Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford OX1 3NP (United Kingdom); Wieczorek, D.; Zirnbauer, M.R. [Institut für Theoretische Physik, Universität zu Köln, Zülpicher Straße 77, 50937 Köln (Germany)

2017-05-15

In this work we put forward an effective Gaussian free field description of critical wavefunctions at the transition between plateaus of the integer quantum Hall effect. To this end, we expound our earlier proposal that powers of critical wave intensities prepared via point contacts behave as pure scaling fields obeying an Abelian operator product expansion. Our arguments employ the framework of conformal field theory and, in particular, lead to a multifractality spectrum which is parabolic. We also derive a number of old and new identities that hold exactly at the lattice level and hinge on the correspondence between the Chalker–Coddington network model and a supersymmetric vertex model.

The Occurrence of Anomalous Conductance Plateaus and Spin Textures in Quantum Point Contacts

Science.gov (United States)

Wan, J.; Cahay, M.; Debray, P.; Newrock, R.

2010-03-01

Recently, we used a NEGF formalism [1] to provide a theoretical explanation for the experimentally observed 0.5G0 (G0=2e^2/h) plateau in the conductance of side-gated quantum point contacts (QPCs) in the presence of lateral spin-orbit coupling (LSOC) [2]. We showed that the 0.5G0 plateau appears in the QPCs without any external magnetic field as a result of three ingredients: an asymmetric lateral confinement, a LSOC, and a strong electron-electron (e-e) interaction. In this report, we present the results of simulations for a wide range of QPC dimensions and biasing parameters showing that the same physics predicts the appearance of other anomalous plateaus at non-integer values of G0, including the well-known 0.7G0 anomaly. These features are related to a plethora of spin textures in the QPC that depend sensitively on material, device, biasing parameters, temperature, and the strength of the e-e interaction. [1] J. Wan, M. Cahay, P. Debray, and R.S. Newrock, Phys. Rev. B 80, 155440 (2009). [2] P. Debray, S.M. Rahman, J. Wan, R.S. Newrock, M. Cahay, A.T. Ngo, S.E. Ulloa, S.T. Herbert, M. Muhammad, and M. Johnson, Nature Nanotech. 4, 759 (2009).

S-parts of terms of integer linear recurrence sequences

NARCIS (Netherlands)

Bugeaud, Y.; Evertse, J.H.

2017-01-01

Let S = {q1 , . . . , qs } be a finite, non-empty set of distinct prime numbers. For a non-zero integer m, write m = q1^ r1 . . . qs^rs M, where r1 , . . . , rs  are non-negative integers and M is an integer relatively prime to q1 . . . qs. We define the S-part [m]_S of m by [m]_S := q1^r1 . . .

Integer channels in nonuniform non-equilibrium 2D systems

Science.gov (United States)

Shikin, V.

2018-01-01

We discuss the non-equilibrium properties of integer channels in nonuniform 2D electron (hole) systems in the presence of a strong magnetic field. The results are applied to a qualitative explanation of the Corbino disk current-voltage characteristics (IVC) in the quantum Hall effect (QHE) regime. Special consideration is paid to the so-called "QHE breakdown" effect, which is readily observed in both the Hall bar and Corbino geometries of the tested cells. The QHE breakdown is especially evident in the Corbino samples, allowing for a more in-depth study of these effects.

Widespread erosion on high plateaus during recent glaciations in Scandinavia

DEFF Research Database (Denmark)

Andersen, Jane L.; Egholm, David L.; Knudsen, Mads F.

2018-01-01

Glaciers create some of Earth's steepest topography; yet, many areas that were repeatedly overridden by ice sheets in the last few million years include extensive plateaus. The distinct geomorphic contrast between plateaus and the glacial troughs that dissect them has sustained two long-held hypo......Glaciers create some of Earth's steepest topography; yet, many areas that were repeatedly overridden by ice sheets in the last few million years include extensive plateaus. The distinct geomorphic contrast between plateaus and the glacial troughs that dissect them has sustained two long......-held hypotheses: first, that ice sheets perform insignificant erosion beyond glacial troughs, and, second, that the plateaus represent ancient pre-glacial landforms bearing information of tectonic and geomorphic history prior to Pliocene-Pleistocene global cooling (similar to 3.5 Myr ago). Here we show...... that the Fennoscandian ice sheets drove widespread erosion across plateaus far beyond glacial troughs. We apply inverse modelling to 118 new cosmogenic Be-10 and Al-26 measurements to quantify ice sheet erosion on the plateaus fringing the Sognefjorden glacial trough in western Norway. Our findings demonstrate...

Investigating Students’ Development of Learning Integer Concept and Integer Addition

Directory of Open Access Journals (Sweden)

Nenden Octavarulia Shanty

2016-09-01

Full Text Available This research aimed at investigating students’ development of learning integer concept and integer addition. The investigation was based on analyzing students’ works in solving the given mathematical problems in each instructional activity designed based on Realistic Mathematics Education (RME levels. Design research was chosen to achieve and to contribute in developing a local instruction theory for teaching and learning of integer concept and integer addition. In design research, the Hypothetical Learning Trajectory (HLT plays important role as a design and research instrument. It was designed in the phase of preliminary design and tested to three students of grade six OASIS International School, Ankara – Turkey. The result of the experiments showed that temperature in the thermometer context could stimulate students’ informal knowledge of integer concept. Furthermore, strategies and tools used by the students in comparing and relating two temperatures were gradually be developed into a more formal mathematics. The representation of line inside thermometer which then called the number line could bring the students to the last activity levels, namely rules for adding integer, and became the model for more formal reasoning. Based on these findings, it can be concluded that students’ learning integer concept and integer addition developed through RME levels.Keywords: integer concept, integer addition, Realistic Mathematics Education DOI: http://dx.doi.org/10.22342/jme.7.2.3538.57-72

Quantum Integers

International Nuclear Information System (INIS)

Khrennikov, Andrei; Klein, Moshe; Mor, Tal

2010-01-01

In number theory, a partition of a positive integer n is a way of writing n as a sum of positive integers. The number of partitions of n is given by the partition function p(n). Inspired by quantum information processing, we extend the concept of partitions in number theory as follows: for an integer n, we treat each partition as a basis state of a quantum system representing that number n, so that the Hilbert-space that corresponds to that integer n is of dimension p(n); the 'classical integer' n can thus be generalized into a (pure) quantum state ||ψ(n) > which is a superposition of the partitions of n, in the same way that a quantum bit (qubit) is a generalization of a classical bit. More generally, ρ(n) is a density matrix in that same Hilbert-space (a probability distribution over pure states). Inspired by the notion of quantum numbers in quantum theory (such as in Bohr's model of the atom), we then try to go beyond the partitions, by defining (via recursion) the notion of 'sub-partitions' in number theory. Combining the two notions mentioned above, sub-partitions and quantum integers, we finally provide an alternative definition of the quantum integers [the pure-state |ψ'(n)> and the mixed-state ρ'(n),] this time using the sub-partitions as the basis states instead of the partitions, for describing the quantum number that corresponds to the integer n.

Magnetic quantum oscillations of diagonal conductivity in a two-dimensional conductor with a weak square superlattice modulation under conditions of the integer quantum Hall effect

International Nuclear Information System (INIS)

Gvozdikov, V M; Taut, M

2009-01-01

We report on analytical and numerical studies of the magnetic quantum oscillations of the diagonal conductivity σ xx in a two-dimensional conductor with a weak square superlattice modulation under conditions of the integer quantum Hall (IQHE) effect. The quantum Hall effect in such a system differs from the conventional IQHE, in which the finite width of the Landau bands is due to disorder only. The superlattice modulation potential yields a fractal splitting of the Landau levels into Hofstadter minibands. For rational flux through a unit cell, the minibands have a finite width and intrinsic dispersion relations. We consider a regime, now accessible experimentally, in which disorder does not wash out the fractal internal gap structure of the Landau bands completely. We found the following distinctions from the conventional IQHE produced by the superlattice: (i) the peaks in diagonal conductivity are split due to the Hofstadter miniband structure of Landau bands; (ii) the number of split peaks in the bunch, their positions and heights depend irregularly on the magnetic field and the Fermi energy; (iii) the gaps between the split Landau bands (and related quantum Hall plateaus) become narrower with the superlattice modulation than without it.

Self-affine scaling from non-integer phase-space partition in $\\pi^{+}p$ and $K^{+}p$ collisions at 250 GeV/$c$

CERN Document Server

Agababian, N M

1998-01-01

A factorial-moment analysis with real (integer and non-integer) phase space partition is applied to $\\pi^+$p and K$^+$p collisions at 250 GeV/$c$. Clear evidence is shown for self-affine rather than self-similar power-law scaling in multiparticle production. The three-dimensional self-affine second-order scaling exponent is determined to be 0.061$\\pm$0.010.

Imaging the Conductance of Integer and Fractional Quantum Hall Edge States

Directory of Open Access Journals (Sweden)

Nikola Pascher

2014-01-01

Full Text Available We measure the conductance of a quantum point contact while the biased tip of a scanning probe microscope induces a depleted region in the electron gas underneath. At a finite magnetic field, we find plateaus in the real-space maps of the conductance as a function of tip position at integer (ν=1, 2, 3, 4, 6, 8 and fractional (ν=1/3, 2/3, 5/3, 4/5 values of transmission. They resemble theoretically predicted compressible and incompressible stripes of quantum Hall edge states. The scanning tip allows us to shift the constriction limiting the conductance in real space over distances of many microns. The resulting stripes of integer and fractional filling factors are rugged on scales of a few hundred nanometers, i.e., on a scale much smaller than the zero-field elastic mean free path of the electrons. Our experiments demonstrate that microscopic inhomogeneities are relevant even in high-quality samples and lead to locally strongly fluctuating widths of incompressible regions even down to their complete suppression for certain tip positions. The macroscopic quantization of the Hall resistance measured experimentally in a nonlocal contact configuration survives in the presence of these inhomogeneities, and the relevant local energy scale for the ν=2 state turns out to be independent of tip position.

Effect of disorders on topological phases in one-dimensional optical superlattices

International Nuclear Information System (INIS)

Wang Zhizhou; Wu Yidong; Du Huijing; Jing Xili

2016-01-01

In a recent paper, Lang et al. proposed that edge states and topological phases can be observed in one-dimensional optical superlattices. They showed that the topological phases can be revealed by observing the density profile of a trapped fermion system, which displays plateaus with their positions. However, disorders are not considered in their model. To study the effect of disorders on the topological phases, we introduce random potentials to the model for optical superlattcies. Our calculations show that edge states are robust against the disorders. We find the edge states are very sensitive to the number of the sites in the optical superlattice and we propose a simple rule to describe the relationship between the edge states and the number of sites. The density plateaus are also robust against weak disorders provided that the average density is calculated over a long interval. The widths of the plateaus are proportional to the widths of the bulk energy gaps when there are disorders. The disorders can diminish the bulk energy gaps. So the widths of the plateaus decrease with the increase of disorders and the density plateaus disappear when disorders are too strong. The results in our paper can be used to guide the experimental detection of topological phases in one-dimensional systems. (paper)

Computation of a numerically satisfactory pair of solutions of the differential equation for conical functions of non-negative integer orders

NARCIS (Netherlands)

T.M. Dunster (Mark); A. Gil (Amparo); J. Segura (Javier); N.M. Temme (Nico)

2014-01-01

textabstractWe consider the problem of computing satisfactory pair of solutions of the differential equation for Legendre functions of non-negative integer order $\\mu$ and degree $-\\frac12+i\\tau$, where $\\tau$ is a non-negative real parameter. Solutions of this equation are the conical functions

Crustal volumes of the continents and of oceanic and continental submarine plateaus

Science.gov (United States)

Schubert, G.; Sandwell, D.

1989-01-01

Using global topographic data and the assumption of Airy isostasy, it is estimated that the crustal volume of the continents is 7182 X 10 to the 6th cu km. The crustal volumes of the oceanic and continental submarine plateaus are calculated at 369 X 10 to the 6th cu km and 242 X 10 to the 6th cu km, respectively. The total continental crustal volume is found to be 7581 X 10 to the 6th cu km, 3.2 percent of which is comprised of continental submarine plateaus on the seafloor. An upper bound on the contintental crust addition rate by the accretion of oceanic plateaus is set at 3.7 cu km/yr. Subduction of continental submarine plateaus with the oceanic lithosphere on a 100 Myr time scale yields an upper bound to the continental crustal subtraction rate of 2.4 cu km/yr.

Integer anatomy

Energy Technology Data Exchange (ETDEWEB)

Doolittle, R. [ONR, Arlington, VA (United States)

1994-11-15

The title integer anatomy is intended to convey the idea of a systematic method for displaying the prime decomposition of the integers. Just as the biological study of anatomy does not teach us all things about behavior of species neither would we expect to learn everything about the number theory from a study of its anatomy. But, some number-theoretic theorems are illustrated by inspection of integer anatomy, which tend to validate the underlying structure and the form as developed and displayed in this treatise. The first statement to be made in this development is: the way structure of the natural numbers is displayed depends upon the allowed operations.

Efficient numerical simulation of non-integer-order space-fractional reaction-diffusion equation via the Riemann-Liouville operator

Science.gov (United States)

Owolabi, Kolade M.

2018-03-01

In this work, we are concerned with the solution of non-integer space-fractional reaction-diffusion equations with the Riemann-Liouville space-fractional derivative in high dimensions. We approximate the Riemann-Liouville derivative with the Fourier transform method and advance the resulting system in time with any time-stepping solver. In the numerical experiments, we expect the travelling wave to arise from the given initial condition on the computational domain (-∞, ∞), which we terminate in the numerical experiments with a large but truncated value of L. It is necessary to choose L large enough to allow the waves to have enough space to distribute. Experimental results in high dimensions on the space-fractional reaction-diffusion models with applications to biological models (Fisher and Allen-Cahn equations) are considered. Simulation results reveal that fractional reaction-diffusion equations can give rise to a range of physical phenomena when compared to non-integer-order cases. As a result, most meaningful and practical situations are found to be modelled with the concept of fractional calculus.

Multiparametric programming based algorithms for pure integer and mixed-integer bilevel programming problems

KAUST Repository

Domínguez, Luis F.

2010-12-01

This work introduces two algorithms for the solution of pure integer and mixed-integer bilevel programming problems by multiparametric programming techniques. The first algorithm addresses the integer case of the bilevel programming problem where integer variables of the outer optimization problem appear in linear or polynomial form in the inner problem. The algorithm employs global optimization techniques to convexify nonlinear terms generated by a reformulation linearization technique (RLT). A continuous multiparametric programming algorithm is then used to solve the reformulated convex inner problem. The second algorithm addresses the mixed-integer case of the bilevel programming problem where integer and continuous variables of the outer problem appear in linear or polynomial forms in the inner problem. The algorithm relies on the use of global multiparametric mixed-integer programming techniques at the inner optimization level. In both algorithms, the multiparametric solutions obtained are embedded in the outer problem to form a set of single-level (M)(I)(N)LP problems - which are then solved to global optimality using standard fixed-point (global) optimization methods. Numerical examples drawn from the open literature are presented to illustrate the proposed algorithms. © 2010 Elsevier Ltd.

Extension of the direct statistical approach to a volume parameter model (non-integer splitting)

International Nuclear Information System (INIS)

Burn, K.W.

1990-01-01

The Direct Statistical Approach is a rigorous mathematical derivation of the second moment for surface splitting and Russian Roulette games attached to the Monte Carlo modelling of fixed source particle transport. It has been extended to a volume parameter model (involving non-integer ''expected value'' splitting), and then to a cell model. The cell model gives second moment and time functions that have a closed form. This suggests the possibility of two different methods of solution of the optimum splitting/Russian Roulette parameters. (author)

Integer programming

CERN Document Server

Conforti, Michele; Zambelli, Giacomo

2014-01-01

This book is an elegant and rigorous presentation of integer programming, exposing the subject’s mathematical depth and broad applicability. Special attention is given to the theory behind the algorithms used in state-of-the-art solvers. An abundance of concrete examples and exercises of both theoretical and real-world interest explore the wide range of applications and ramifications of the theory. Each chapter is accompanied by an expertly informed guide to the literature and special topics, rounding out the reader’s understanding and serving as a gateway to deeper study. Key topics include: formulations polyhedral theory cutting planes decomposition enumeration semidefinite relaxations Written by renowned experts in integer programming and combinatorial optimization, Integer Programming is destined to become an essential text in the field.

Integer Quantum Magnon Hall Plateau-Plateau Transition in a Spin Ice Model

OpenAIRE

Xu, Baolong; Ohtsuki, Tomi; Shindou, Ryuichi

2016-01-01

Low-energy magnon bands in a two-dimensional spin ice model become integer quantum magnon Hall bands. By calculating the localization length and the two-terminal conductance of magnon transport, we show that the magnon bands with disorders undergo a quantum phase transition from an integer quantum magnon Hall regime to a conventional magnon localized regime. Finite size scaling analysis as well as a critical conductance distribution shows that the quantum critical point belongs to the same un...

A simple approximation of moments of the quasi-equilibrium distribution of an extended stochastic theta-logistic model with non-integer powers.

Science.gov (United States)

Bhowmick, Amiya Ranjan; Bandyopadhyay, Subhadip; Rana, Sourav; Bhattacharya, Sabyasachi

2016-01-01

The stochastic versions of the logistic and extended logistic growth models are applied successfully to explain many real-life population dynamics and share a central body of literature in stochastic modeling of ecological systems. To understand the randomness in the population dynamics of the underlying processes completely, it is important to have a clear idea about the quasi-equilibrium distribution and its moments. Bartlett et al. (1960) took a pioneering attempt for estimating the moments of the quasi-equilibrium distribution of the stochastic logistic model. Matis and Kiffe (1996) obtain a set of more accurate and elegant approximations for the mean, variance and skewness of the quasi-equilibrium distribution of the same model using cumulant truncation method. The method is extended for stochastic power law logistic family by the same and several other authors (Nasell, 2003; Singh and Hespanha, 2007). Cumulant truncation and some alternative methods e.g. saddle point approximation, derivative matching approach can be applied if the powers involved in the extended logistic set up are integers, although plenty of evidence is available for non-integer powers in many practical situations (Sibly et al., 2005). In this paper, we develop a set of new approximations for mean, variance and skewness of the quasi-equilibrium distribution under more general family of growth curves, which is applicable for both integer and non-integer powers. The deterministic counterpart of this family of models captures both monotonic and non-monotonic behavior of the per capita growth rate, of which theta-logistic is a special case. The approximations accurately estimate the first three order moments of the quasi-equilibrium distribution. The proposed method is illustrated with simulated data and real data from global population dynamics database. Copyright © 2015 Elsevier Inc. All rights reserved.

DESIGN STUDY: INTEGER SUBTRACTION OPERATION TEACHING LEARNING USING MULTIMEDIA IN PRIMARY SCHOOL

Directory of Open Access Journals (Sweden)

Rendi Muhammad Aris

2016-12-01

Full Text Available This study aims to develop a learning trajectory to help students understand concept of subtraction of integers using multimedia in the fourth grade. This study is thematic integrative learning in Curriculum 2013 PMRI based. The method used is design research consists of three stages; preparing for the experiment, design experiment, retrospective analysis. The studied was conducted on 20 students of grade four SDN 1 Muara Batun, OKI. The activities of students in this study consisted of six learning trajectories. The first activity asks the students to classify heroism and non-heroism acts, summarize, and classify integers and non-integer. The second activity asks the students to answer the questions in the film given. The third activity asks students to count the remaining gravel in the film. The fourth activity asks students to count remaining spent money in the film. The fifth activity invites students to play rubber seeds in the bag. The last activity asks students to answer the questions in the student worksheet. The media used along the learning activities are a ruler, rubber seed, student worksheet, money, gravel, and film. The results indicate that the learning trajectory using multimedia help students understand the concept of integer subtraction integer. Keywords: Subtraction Integer, PMRI, Multimedia DOI: http://dx.doi.org/10.22342/jme.8.1.3233.95-102

Rhizomes and plateaus: A study of digital communities of practice in University College English Teaching

DEFF Research Database (Denmark)

Kjærgaard, Thomas

2017-01-01

Rhizomes and plateaus: A study of digital communities of practice in University College English Teaching......Rhizomes and plateaus: A study of digital communities of practice in University College English Teaching...

Non extensive statistics and entropic gravity in a non-integer dimensional space

International Nuclear Information System (INIS)

Abreu, Everton M.C.; Ananias Neto, Jorge; Godinho, Cresus F.L.

2013-01-01

Full text: The idea that gravity can be originated from thermodynamics features has begun with the discovering that black hole physics is connected to the thermodynamics laws. These concepts were strongly boosted after Jacobson's work, where the Einstein equations were obtained from general thermodynamics approaches. In a recent work, Padmanabhan obtained an interpretation of gravity as an equipartition law. In Verlinde's thermo gravitational formalism, the temperature and the acceleration are connected via Unruh effect. At the same time, he combined the holographic principle with an equipartition law, where the number of bits is proportional to the area of the holographic surface. Bits were used to define the microscopic degrees of freedom. With these ingredients, the entropic force combined with the holographic principle and the equipartition law originated the Newton's law of gravitation. The possible interpretation of Verlinde's result is that gravity is not an underlying concept, but an emergent one. It originates from the statistical behavior of the holographic screen microscopic degrees of freedom. Following these ideas, the current literature has grown in an accelerated production from Coulomb force and symmetry considerations of entropic force to cosmology and loop quantum. In this work we introduced the Newton's constant in a fractal space as a function of the non extensive one. With this result we established a relation between the Tsallis non extensive parameter and the dimension of this fractal space. Using Verlinde's formalism we used these fractal ideas combined with the concept of entropic gravity to calculate the number of bits of an holographic surface in this non-integer dimensional space, a fractal holographic screen. We introduced a fundamental length, a Planck-like length, into this space as a function of this fractal holographic screen radius. Finally, we consider superior dimensions in this analysis. (author)

An integer optimization algorithm for robust identification of non-linear gene regulatory networks

Directory of Open Access Journals (Sweden)

Chemmangattuvalappil Nishanth

2012-09-01

Full Text Available Abstract Background Reverse engineering gene networks and identifying regulatory interactions are integral to understanding cellular decision making processes. Advancement in high throughput experimental techniques has initiated innovative data driven analysis of gene regulatory networks. However, inherent noise associated with biological systems requires numerous experimental replicates for reliable conclusions. Furthermore, evidence of robust algorithms directly exploiting basic biological traits are few. Such algorithms are expected to be efficient in their performance and robust in their prediction. Results We have developed a network identification algorithm to accurately infer both the topology and strength of regulatory interactions from time series gene expression data in the presence of significant experimental noise and non-linear behavior. In this novel formulism, we have addressed data variability in biological systems by integrating network identification with the bootstrap resampling technique, hence predicting robust interactions from limited experimental replicates subjected to noise. Furthermore, we have incorporated non-linearity in gene dynamics using the S-system formulation. The basic network identification formulation exploits the trait of sparsity of biological interactions. Towards that, the identification algorithm is formulated as an integer-programming problem by introducing binary variables for each network component. The objective function is targeted to minimize the network connections subjected to the constraint of maximal agreement between the experimental and predicted gene dynamics. The developed algorithm is validated using both in silico and experimental data-sets. These studies show that the algorithm can accurately predict the topology and connection strength of the in silico networks, as quantified by high precision and recall, and small discrepancy between the actual and predicted kinetic parameters

PageRank of integers

International Nuclear Information System (INIS)

Frahm, K M; Shepelyansky, D L; Chepelianskii, A D

2012-01-01

We up a directed network tracing links from a given integer to its divisors and analyze the properties of the Google matrix of this network. The PageRank vector of this matrix is computed numerically and it is shown that its probability is approximately inversely proportional to the PageRank index thus being similar to the Zipf law and the dependence established for the World Wide Web. The spectrum of the Google matrix of integers is characterized by a large gap and a relatively small number of nonzero eigenvalues. A simple semi-analytical expression for the PageRank of integers is derived that allows us to find this vector for matrices of billion size. This network provides a new PageRank order of integers. (paper)

Integer programming theory, applications, and computations

CERN Document Server

Taha, Hamdy A

1975-01-01

Integer Programming: Theory, Applications, and Computations provides information pertinent to the theory, applications, and computations of integer programming. This book presents the computational advantages of the various techniques of integer programming.Organized into eight chapters, this book begins with an overview of the general categorization of integer applications and explains the three fundamental techniques of integer programming. This text then explores the concept of implicit enumeration, which is general in a sense that it is applicable to any well-defined binary program. Other

Hard equality constrained integer knapsacks

NARCIS (Netherlands)

Aardal, K.I.; Lenstra, A.K.; Cook, W.J.; Schulz, A.S.

2002-01-01

We consider the following integer feasibility problem: "Given positive integer numbers a 0, a 1,..., a n, with gcd(a 1,..., a n) = 1 and a = (a 1,..., a n), does there exist a nonnegative integer vector x satisfying ax = a 0?" Some instances of this type have been found to be extremely hard to solve

Multiparametric programming based algorithms for pure integer and mixed-integer bilevel programming problems

KAUST Repository

Domí nguez, Luis F.; Pistikopoulos, Efstratios N.

2010-01-01

continuous multiparametric programming algorithm is then used to solve the reformulated convex inner problem. The second algorithm addresses the mixed-integer case of the bilevel programming problem where integer and continuous variables of the outer problem

Corestriction principle for non-Abelian cohomology of reductive group schemes over Dedekind rings of integers of local and global fields

International Nuclear Information System (INIS)

Nguyen Quoc Thang

2006-12-01

We prove some new results on Corestriction principle for non-abelian cohomology of group schemes over the rings of integers of local and global fields. Some connections with Grothendieck - Serre's conjecture are indicated, and applications to the study of class groups of algebraic groups over global fields are given. (author)

6th Conference on Non-integer Order Calculus and Its Applications

CERN Document Server

Łukaniszyn, Marian; Stanisławski, Rafał

2015-01-01

This volume presents selected aspects of non-integer, or fractional order systems, whose analysis, synthesis and applications have increasingly become a real challenge for various research communities, ranging from science to engineering. The spectrum of applications of the fractional order calculus has incredibly expanded, in fact it would be hard to find a science/engineering-related subject area where the fractional calculus had not been incorporated. The content of the fractional calculus is ranged from pure mathematics to engineering implementations and so is the content of this volume. The volume is subdivided into six parts, reflecting particular aspects of the fractional order calculus. The first part contains a single invited paper on a new formulation of fractional-order descriptor observers for fractional-order descriptor continous LTI systems. The second part provides new elements to the mathematical theory of fractional-order systems. In the third part of this volume, a bunch of new results in ap...

Ground states, magnetization plateaus and bipartite entanglement of frustrated spin-1/2 Ising-Heisenberg and Heisenberg triangular tubes

International Nuclear Information System (INIS)

Alécio, Raphael C.; Lyra, Marcelo L.; Strečka, Jozef

2016-01-01

The ground-state phase diagram, magnetization process and bipartite entanglement of the frustrated spin-1/2 Ising-Heisenberg and Heisenberg triangular tube (three-leg ladder) are investigated in a non-zero external magnetic field. The exact ground-state phase diagram of the spin-1/2 Ising-Heisenberg tube with Heisenberg intra-rung and Ising inter-rung couplings consists of six distinct gapped phases, which manifest themselves in a magnetization curve as intermediate plateaus at zero, one-third and two-thirds of the saturation magnetization. Four out of six available ground states exhibit quantum entanglement between two spins from the same triangular unit evidenced by a non-zero concurrence. Density-matrix renormalization group calculations are used in order to construct the ground-state phase diagram of the analogous but purely quantum spin-1/2 Heisenberg tube with Heisenberg intra- and inter-rung couplings, which consists of four gapped and three gapless phases. The Heisenberg tube shows a continuous change of the magnetization instead of a plateau at zero magnetization, while the intermediate one-third and two-thirds plateaus may be present or not in the zero-temperature magnetization curve. - Highlights: • Ground-state properties of Ising-Heisenberg and full Heisenberg spin tubes are studied. • Phases with 1/3 and 2/3 magnetization plateaus are present in both models. • We unveil the region in the parameter space on which inter-rung quantum fluctuations are relevant. • The full Heisenberg tube exhibits quantum bipartite entanglement between intra- as well as inter-rung spins.

An overview of solution methods for multi-objective mixed integer linear programming programs

DEFF Research Database (Denmark)

Andersen, Kim Allan; Stidsen, Thomas Riis

Multiple objective mixed integer linear programming (MOMIP) problems are notoriously hard to solve to optimality, i.e. finding the complete set of non-dominated solutions. We will give an overview of existing methods. Among those are interactive methods, the two phases method and enumeration...... methods. In particular we will discuss the existing branch and bound approaches for solving multiple objective integer programming problems. Despite the fact that branch and bound methods has been applied successfully to integer programming problems with one criterion only a few attempts has been made...

Strong degradation of palsas and peat plateaus in northern Norway during the last 60 years

Directory of Open Access Journals (Sweden)

A. F. Borge

2017-01-01

vegetation, wildlife, hydrology and carbon cycle. Firstly, we have systematically mapped the occurrence of palsas and peat plateaus in the northernmost county of Norway (Finnmark, ∼ 50 000 km2 by manual interpretation of aerial images from 2005 to 2014 at a spatial resolution of 250 m. At this resolution, mires and wetlands with palsas or peat plateaus occur in about 850 km2 of Finnmark, with the actual palsas and peat plateaus underlain by permafrost covering a surface area of approximately 110 km2. Secondly, we have quantified the lateral changes of the extent of palsas and peat plateaus for four study areas located along a NW–SE transect through Finnmark by utilizing repeat aerial imagery from the 1950s to the 2010s. The results of the lateral changes reveal a total decrease of 33–71 % in the areal extent of palsas and peat plateaus during the study period, with the largest lateral change rates observed in the last decade. However, the results indicate that degradation of palsas and peat plateaus in northern Norway has been a consistent process during the second half of the 20th century and possibly even earlier. Significant rates of areal change are observed in all investigated time periods since the 1950s, and thermokarst landforms observed on aerial images from the 1950s suggest that lateral degradation was already an ongoing process at this time. The results of this study show that lateral erosion of palsas and peat plateaus is an important pathway for permafrost degradation in the sporadic permafrost zone in northern Scandinavia. While the environmental factors governing the rate of erosion are not yet fully understood, we note a moderate increase in air temperature, precipitation and snow depth during the last few decades in the region.

Applied Integer Programming Modeling and Solution

CERN Document Server

Chen, Der-San; Dang, Yu

2011-01-01

An accessible treatment of the modeling and solution of integer programming problems, featuring modern applications and software In order to fully comprehend the algorithms associated with integer programming, it is important to understand not only how algorithms work, but also why they work. Applied Integer Programming features a unique emphasis on this point, focusing on problem modeling and solution using commercial software. Taking an application-oriented approach, this book addresses the art and science of mathematical modeling related to the mixed integer programming (MIP) framework and

Construction of Fixed Rate Non-Binary WOM Codes Based on Integer Programming

Science.gov (United States)

Fujino, Yoju; Wadayama, Tadashi

In this paper, we propose a construction of non-binary WOM (Write-Once-Memory) codes for WOM storages such as flash memories. The WOM codes discussed in this paper are fixed rate WOM codes where messages in a fixed alphabet of size $M$ can be sequentially written in the WOM storage at least $t^*$-times. In this paper, a WOM storage is modeled by a state transition graph. The proposed construction has the following two features. First, it includes a systematic method to determine the encoding regions in the state transition graph. Second, the proposed construction includes a labeling method for states by using integer programming. Several novel WOM codes for $q$ level flash memories with 2 cells are constructed by the proposed construction. They achieve the worst numbers of writes $t^*$ that meet the known upper bound in many cases. In addition, we constructed fixed rate non-binary WOM codes with the capability to reduce ICI (inter cell interference) of flash cells. One of the advantages of the proposed construction is its flexibility. It can be applied to various storage devices, to various dimensions (i.e, number of cells), and various kind of additional constraints.

Load Frequency Control in Microgrids Based on a Stochastic Non-Integer Controller

DEFF Research Database (Denmark)

Khooban, Mohammad-Hassan; Niknam, Taher; Shasadeghi, Mokhtar

2018-01-01

of battery energy storage systems (BESS) can solve the unbalance effects between the load and supply of an isolated MG, their high cost and tendency toward degradation are restrictive factors, which call for the use of alternative power balancing options. In recent years, the concept of utilizing the BESSs...... of EVs, also known as vehicle-to-grid (V2G) concept, for frequency support of MGs has attracted a lot of attention. In order to allow the V2G controller operate optimally under a wide range of operation conditions caused by the intermittent behavior of renewable energy resources (RESs), a new multi...... hole optimization algorithm (MBHA) is utilized for the adaptive tuning of the non-integer fuzzy PID controller coefficients. The performance of the proposed LFC is evaluated by using real world wind and solar radiation data. Finally, the extensive studies and hardware-in-the-loop (HIL) simulations...

Slip and Slide Method of Factoring Trinomials with Integer Coefficients over the Integers

Science.gov (United States)

Donnell, William A.

2012-01-01

In intermediate and college algebra courses there are a number of methods for factoring quadratic trinomials with integer coefficients over the integers. Some of these methods have been given names, such as trial and error, reversing FOIL, AC method, middle term splitting method and slip and slide method. The purpose of this article is to discuss…

An Integer Programming Model for Multi-Echelon Supply Chain Decision Problem Considering Inventories

Science.gov (United States)

Harahap, Amin; Mawengkang, Herman; Siswadi; Effendi, Syahril

2018-01-01

In this paper we address a problem that is of significance to the industry, namely the optimal decision of a multi-echelon supply chain and the associated inventory systems. By using the guaranteed service approach to model the multi-echelon inventory system, we develop a mixed integer; programming model to simultaneously optimize the transportation, inventory and network structure of a multi-echelon supply chain. To solve the model we develop a direct search approach using a strategy of releasing nonbasic variables from their bounds, combined with the “active constraint” method. This strategy is used to force the appropriate non-integer basic variables to move to their neighbourhood integer points.

A statistical mechanical approach to restricted integer partition functions

Science.gov (United States)

Zhou, Chi-Chun; Dai, Wu-Sheng

2018-05-01

The main aim of this paper is twofold: (1) suggesting a statistical mechanical approach to the calculation of the generating function of restricted integer partition functions which count the number of partitions—a way of writing an integer as a sum of other integers under certain restrictions. In this approach, the generating function of restricted integer partition functions is constructed from the canonical partition functions of various quantum gases. (2) Introducing a new type of restricted integer partition functions corresponding to general statistics which is a generalization of Gentile statistics in statistical mechanics; many kinds of restricted integer partition functions are special cases of this restricted integer partition function. Moreover, with statistical mechanics as a bridge, we reveal a mathematical fact: the generating function of restricted integer partition function is just the symmetric function which is a class of functions being invariant under the action of permutation groups. Using this approach, we provide some expressions of restricted integer partition functions as examples.

Hydrogeology and hydrologic conditions of the Ozark Plateaus aquifer system

Science.gov (United States)

Hays, Phillip D.; Knierim, Katherine J.; Breaker, Brian K.; Westerman, Drew A.; Clark, Brian R.

2016-11-23

The hydrogeology and hydrologic characteristics of the Ozark Plateaus aquifer system were characterized as part of ongoing U.S. Geological Survey efforts to assess groundwater availability across the Nation. The need for such a study in the Ozark Plateaus physiographic province (Ozark Plateaus) is highlighted by increasing demand on groundwater resources by the 5.3 million people of the Ozark Plateaus, water-level declines in some areas, and potential impacts of climate change on groundwater availability. The subject study integrates knowledge gained through local investigation within a regional perspective to develop a regional conceptual model of groundwater flow in the Ozark Plateaus aquifer system (Ozark system), a key phase of groundwater availability assessment. The Ozark system extends across much of southern Missouri and northwestern and north-central Arkansas and smaller areas of southeastern Kansas and northeastern Oklahoma. The region is one of the major karst landscapes in the United States, and karst aquifers are predominant in the Ozark system. Groundwater flow is ultimately controlled by aquifer and confining unit lithologies and stratigraphic relations, geologic structure, karst development, and the character of surficial lithologies and regolith mantle. The regolith mantle is a defining element of Ozark Plateaus karst, affecting recharge, karst development, and vulnerability to surface-derived contaminants. Karst development is more advanced—as evidenced by larger springs, hydraulic characteristics, and higher well yields—in the Salem Plateau and in the northern part of the Springfield Plateau (generally north of the Arkansas-Missouri border) as compared with the southern part of the Springfield Plateau in Arkansas, largely due to thinner, less extensive regolith and purer carbonate lithology.Precipitation is the ultimate source of all water to the Ozark system, and the hydrologic budget for the Ozark system includes inputs from recharge

Integer-valued trawl processes

DEFF Research Database (Denmark)

Barndorff-Nielsen, Ole E.; Lunde, Asger; Shephard, Neil

2014-01-01

the probabilistic properties of such processes in detail and, in addition, study volatility modulation and multivariate extensions within the new modelling framework. Moreover, we describe how the parameters of a trawl process can be estimated and obtain promising estimation results in our simulation study. Finally......This paper introduces a new continuous-time framework for modelling serially correlated count and integer-valued data. The key component in our new model is the class of integer-valued trawl processes, which are serially correlated, stationary, infinitely divisible processes. We analyse...

Integer and combinatorial optimization

CERN Document Server

Nemhauser, George L

1999-01-01

Rave reviews for INTEGER AND COMBINATORIAL OPTIMIZATION ""This book provides an excellent introduction and survey of traditional fields of combinatorial optimization . . . It is indeed one of the best and most complete texts on combinatorial optimization . . . available. [And] with more than 700 entries, [it] has quite an exhaustive reference list.""-Optima ""A unifying approach to optimization problems is to formulate them like linear programming problems, while restricting some or all of the variables to the integers. This book is an encyclopedic resource for such f

Analysis misconception of integers in microteaching activities

Science.gov (United States)

Setyawati, R. D.; Indiati, I.

2018-05-01

This study view to analyse student misconceptions on integers in microteaching activities. This research used qualitative research design. An integers test contained questions from eight main areas of integers. The Integers material test includes (a) converting the image into fractions, (b) examples of positive numbers including rational numbers, (c) operations in fractions, (d) sorting fractions from the largest to the smallest, and vice versa; e) equate denominator, (f) concept of ratio mark, (g) definition of fraction, and (h) difference between fractions and parts. The results indicated an integers concepts: (1) the students have not been able to define concepts well based on the classification of facts in organized part; (2) The correlational concept: students have not been able to combine interrelated events in the form of general principles; and (3) theoretical concepts: students have not been able to use concepts that facilitate in learning the facts or events in an organized system.

Comparison of linear, mixed integer and non-linear programming methods in energy system dispatch modelling

DEFF Research Database (Denmark)

Ommen, Torben Schmidt; Markussen, Wiebke Brix; Elmegaard, Brian

2014-01-01

In the paper, three frequently used operation optimisation methods are examined with respect to their impact on operation management of the combined utility technologies for electric power and DH (district heating) of eastern Denmark. The investigation focusses on individual plant operation...... differences and differences between the solution found by each optimisation method. One of the investigated approaches utilises LP (linear programming) for optimisation, one uses LP with binary operation constraints, while the third approach uses NLP (non-linear programming). The LP model is used...... as a benchmark, as this type is frequently used, and has the lowest amount of constraints of the three. A comparison of the optimised operation of a number of units shows significant differences between the three methods. Compared to the reference, the use of binary integer variables, increases operation...

On the Delone property of (−β-integers

Directory of Open Access Journals (Sweden)

Wolfgang Steiner

2011-08-01

Full Text Available The (−β-integers are natural generalisations of the β-integers, and thus of the integers, for negative real bases. They can be described by infinite words which are fixed points of anti-morphisms. We show that they are not necessarily uniformly discrete and relatively dense in the real numbers.

Quasi-greedy systems of integer translates

DEFF Research Database (Denmark)

Nielsen, Morten; Sikic, Hrvoje

We consider quasi-greedy systems of integer translates in a finitely generated shift invariant subspace of L2(Rd), that is systems for which the thresholding approximation procedure is well behaved. We prove that every quasi-greedy system of integer translates is also a Riesz basis for its closed...

Quasi-greedy systems of integer translates

DEFF Research Database (Denmark)

Nielsen, Morten; Sikic, Hrvoje

2008-01-01

We consider quasi-greedy systems of integer translates in a finitely generated shift-invariant subspace of L2(Rd), that is systems for which the thresholding approximation procedure is well behaved. We prove that every quasi-greedy system of integer translates is also a Riesz basis for its closed...

A property of assignment type mixed integer linear programming problems

NARCIS (Netherlands)

Benders, J.F.; van Nunen, J.A.E.E.

1982-01-01

In this paper we will proof that rather tight upper bounds can be given for the number of non-unique assignments that are achieved after solving the linear programming relaxation of some types of mixed integer linear assignment problems. Since in these cases the number of splitted assignments is

Magnetization plateaus and ground-state phase diagrams of the S=1 Ising model on the Shastry Sutherland lattice

Science.gov (United States)

Deviren, Seyma Akkaya

2017-02-01

In this research, we have investigated the magnetic properties of the spin-1 Ising model on the Shastry Sutherland lattice with the crystal field interaction by using the effective-field theory with correlations. The effects of the applied field on the magnetization are examined in detail in order to obtain the magnetization plateaus, thus different types of magnetization plateaus, such as 1/4, 1/3, 1/2, 3/5, 2/3 and 7/9 of the saturation, are obtained for strong enough magnetic fields (h). Magnetization plateaus exhibit single, triple, quintuplet and sextuple forms according to the interaction parameters, hence the magnetization plateaus originate from the competition between the crystal field (D) and exchange interaction parameters (J, J‧). The ground-state phase diagrams of the system are presented in three varied planes, namely (h/J, J‧/J), (h/J, D/J) and (D/J, J‧/J) planes. These phase diagrams display the Néel (N), collinear (C) and ferromagnetic (F) phases for certain values of the model parameters. The obtained results are in good agreement with some theoretical and experimental studies.

Allocating the Fixed Resources and Setting Targets in Integer Data Envelopment Analysis

Directory of Open Access Journals (Sweden)

Kobra Gholami

2013-11-01

Full Text Available Data envelopment analysis (DEA is a non-parametric approach to evaluate a set of decision making units (DMUs consuming multiple inputs to produce multiple outputs. Formally, DEA use to estimate the efficiency score into the empirical efficient frontier. Also, DEA can be used to allocate resources and set targets for future forecast. The data are continuous in the standard DEA model whereas there are many problems in the real life that data must be integer such as number of employee, machinery, expert and so on. Thus in this paper we propose an approach to allocate fixed resources and set fixed targets with selective integer assumption that is based on an integer data envelopment analysis (IDEA approach for the first time. The major aim in this approach is preserving the efficiency score of DMUs. We use the concept of benchmarking to reach this aim. The numerical example gets to illustrate the applicability of the proposed method.

Peaks, plateaus, numerical instabilities, and achievable accuracy in Galerkin and norm minimizing procedures for solving Ax=b

Energy Technology Data Exchange (ETDEWEB)

Cullum, J. [IBM T.J. Watson Research Center, Yorktown Heights, NY (United States)

1994-12-31

Plots of the residual norms generated by Galerkin procedures for solving Ax = b often exhibit strings of irregular peaks. At seemingly erratic stages in the iterations, peaks appear in the residual norm plot, intervals of iterations over which the norms initially increase and then decrease. Plots of the residual norms generated by related norm minimizing procedures often exhibit long plateaus, sequences of iterations over which reductions in the size of the residual norm are unacceptably small. In an earlier paper the author discussed and derived relationships between such peaks and plateaus within corresponding Galerkin/Norm Minimizing pairs of such methods. In this paper, through a set of numerical experiments, the author examines connections between peaks, plateaus, numerical instabilities, and the achievable accuracy for such pairs of iterative methods. Three pairs of methods, GMRES/Arnoldi, QMR/BCG, and two bidiagonalization methods are studied.

Ramsey theory on the integers

CERN Document Server

Landman, Bruce M

2003-01-01

Ramsey theory is the study of the structure of mathematical objects that is preserved under partitions. In its full generality, Ramsey theory is quite powerful, but can quickly become complicated. By limiting the focus of this book to Ramsey theory applied to the set of integers, the authors have produced a gentle, but meaningful, introduction to an important and enticing branch of modern mathematics. Ramsey Theory on the Integers offers students something quite rare for a book at this level: a glimpse into the world of mathematical research and the opportunity to begin pondering unsolved problems themselves. In addition to being the first truly accessible book on Ramsey theory, this innovative book also provides the first cohesive study of Ramsey theory on the integers. It contains perhaps the most substantial account of solved and unsolved problems in this blossoming subarea of Ramsey theory. The result is a breakthrough book that will engage students, teachers, and researchers alike.

The Ozark Plateaus Regional Aquifer Study—Documentation of a groundwater-flow model constructed to assess water availability in the Ozark Plateaus

Science.gov (United States)

Clark, Brian R.; Richards, Joseph M.; Knierim, Katherine J.

2018-03-30

Recent short-term drought conditions have emphasized the need to better understand the delicate balance between abundance, sustainability, and scarcity of groundwater in the Ozark Plateaus aquifer system. In 2014, the U.S. Geological Survey began construction of a groundwater-flow model as a tool for the assessment of groundwater availability in the Ozark Plateaus aquifer system. The model was developed to benefit concurrent and future investigations involving groundwater-pumping scenarios, optimization, particle transport, and groundwater-monitoring network analysis.The groundwater model simulates 116 years (1900–2015) of hydrologic conditions and the response of the groundwater system to changes in stress including changes in recharge and groundwater pumping for water supply. Semiseasonal stress periods were simulated from the later part of 1991 to 2015 and represent higher demand and lower recharge in the spring and summer months and lower demand and higher recharge in the fall and winter months. Groundwater pumping increases throughout the simulation period with a maximum rate of about 600 million gallons per day (Mgal/d).The process of matching historical hydrologic data for the Ozark Plateaus aquifer system model was accomplished by a combination of manual changes to parameter values and automated calibration methods. Observation data used in the development and evaluation of the model included 19,045 hydraulic-head observations from 6,683 wells within the model area. Observation data also included stream leakage estimates summed to calculate a net gain or net loss value for approximately 81 named streams.The majority (mean of over 95 percent) of the recharge component is discharged through streams simulated in the model. The total simulated discharge to streams fluctuates seasonally between 7,500 and 17,500 Mgal/d with a mean outflow of 11,500 Mgal/d. Much of the remaining balance between modeled recharge inflows and stream outflows is made up by water

Hydrologic budget and conditions of Permian, Pennsylvanian, and Mississippian aquifers in the Appalachian Plateaus physiographic province

Science.gov (United States)

McCoy, Kurt J.; Yager, Richard M.; Nelms, David L.; Ladd, David E.; Monti,, Jack; Kozar, Mark D.

2015-08-13

In response to challenges to groundwater availability posed by historic land-use practices, expanding development of hydrocarbon resources, and drought, the U.S. Geological Survey Groundwater Resources Program began a regional assessment of the Appalachian Plateaus aquifers in 2013 that incorporated a hydrologic landscape approach to estimate all components of the hydrologic system: surface runoff, base flow from groundwater, and interaction with atmospheric water (precipitation and evapotranspiration). This assessment was intended to complement other Federal and State investigations and provide foundational groundwater-related datasets in the Appalachian Plateaus.

Linear and integer programming made easy

CERN Document Server

Hu, T C

2016-01-01

Linear and integer programming are fundamental toolkits for data and information science and technology, particularly in the context of today’s megatrends toward statistical optimization, machine learning, and big data analytics. Drawn from over 30 years of classroom teaching and applied research experience, this textbook provides a crisp and practical introduction to the basics of linear and integer programming. The authors’ approach is accessible to students from all fields of engineering, including operations research, statistics, machine learning, control system design, scheduling, formal verification, and computer vision. Readers will learn to cast hard combinatorial problems as mathematical programming optimizations, understand how to achieve formulations where the objective and constraints are linear, choose appropriate solution methods, and interpret results appropriately. •Provides a concise introduction to linear and integer programming, appropriate for undergraduates, graduates, a short cours...

Non-neoplastic disorders of the esophagus

International Nuclear Information System (INIS)

Hong, Min Ji; Kim, Young Tong

2013-01-01

Non-neoplastic disorders of the esophagus include esophagitis, esophageal diverticulum, esophageal injury, foreign body, fistulous formation between the esophagus and the surrounding structures and mucocele. Since these disorders have variable symptoms and radiologic findings, it needs to differentiated from other disorders other than esophageal diseases. Being knowledgeable of CT findings suggest that these disorders can help diagnose non-neoplastic disorders of the esophagus. The purpose of this pictorial essay is to review the CT appearance of non-neoplastic disorders of the esophagus.

Positive integer solutions of certain diophantine equations

Indian Academy of Sciences (India)

BIJAN KUMAR PATEL

2018-03-19

Mar 19, 2018 ... integer solutions. They also found all the positive integer solutions of the given equations in terms of Fibonacci and Lucas numbers. Another interesting number sequence which is closely related to the sequence of. Fibonacci numbers is the sequence of balancing numbers. In 1999, Behera et al. [1] intro-.

Neomysis integer: a review

OpenAIRE

Fockedey, N.

2005-01-01

The present chapter aims to be a literature review on the brackish water mysid Neomysis integer, with focus on its feeding ecology, life history aspects, behaviour, physiology, biochemical composition, bioenergetics and ecotoxico10gy. All records on the species, available from literature, are listed as an appendix. The review aims to identify the state-of-the-art and the gaps in our knowledge on the species. Abundant information is available on the distribution patterns of Neomysis integer in...

Automatic Design of Synthetic Gene Circuits through Mixed Integer Non-linear Programming

Science.gov (United States)

Huynh, Linh; Kececioglu, John; Köppe, Matthias; Tagkopoulos, Ilias

2012-01-01

Automatic design of synthetic gene circuits poses a significant challenge to synthetic biology, primarily due to the complexity of biological systems, and the lack of rigorous optimization methods that can cope with the combinatorial explosion as the number of biological parts increases. Current optimization methods for synthetic gene design rely on heuristic algorithms that are usually not deterministic, deliver sub-optimal solutions, and provide no guaranties on convergence or error bounds. Here, we introduce an optimization framework for the problem of part selection in synthetic gene circuits that is based on mixed integer non-linear programming (MINLP), which is a deterministic method that finds the globally optimal solution and guarantees convergence in finite time. Given a synthetic gene circuit, a library of characterized parts, and user-defined constraints, our method can find the optimal selection of parts that satisfy the constraints and best approximates the objective function given by the user. We evaluated the proposed method in the design of three synthetic circuits (a toggle switch, a transcriptional cascade, and a band detector), with both experimentally constructed and synthetic promoter libraries. Scalability and robustness analysis shows that the proposed framework scales well with the library size and the solution space. The work described here is a step towards a unifying, realistic framework for the automated design of biological circuits. PMID:22536398

Binary Positive Semidefinite Matrices and Associated Integer Polytopes

DEFF Research Database (Denmark)

Letchford, Adam N.; Sørensen, Michael Malmros

2012-01-01

We consider the positive semidefinite (psd) matrices with binary entries, along with the corresponding integer polytopes. We begin by establishing some basic properties of these matrices and polytopes. Then, we show that several families of integer polytopes in the literature-the cut, boolean qua...

Neutrosophic Integer Programming Problem

Directory of Open Access Journals (Sweden)

Mai Mohamed

2017-02-01

Full Text Available In this paper, we introduce the integer programming in neutrosophic environment, by considering coffecients of problem as a triangulare neutrosophic numbers. The degrees of acceptance, indeterminacy and rejection of objectives are simultaneously considered.

Garbage-free reversible constant multipliers for arbitrary integers

DEFF Research Database (Denmark)

Mogensen, Torben Ægidius

2013-01-01

We present a method for constructing reversible circuitry for multiplying integers by arbitrary integer constants. The method is based on Mealy machines and gives circuits whose size are (in the worst case) linear in the size of the constant. This makes the method unsuitable for large constants...

A fixed recourse integer programming approach towards a ...

African Journals Online (AJOL)

Regardless of the success that linear programming and integer linear programming has had in applications in engineering, business and economics, one has to challenge the assumed reality that these optimization models represent. In this paper the certainty assumptions of an integer linear program application is ...

Integers annual volume 2013

CERN Document Server

Landman, Bruce

2014-01-01

""Integers"" is a refereed online journal devoted to research in the area of combinatorial number theory. It publishes original research articles in combinatorics and number theory. This work presents all papers of the 2013 volume in book form.

A General Approach for Orthogonal 4-Tap Integer Multiwavelet Transforms

Directory of Open Access Journals (Sweden)

Mingli Jing

2010-01-01

Full Text Available An algorithm for orthogonal 4-tap integer multiwavelet transforms is proposed. We compute the singular value decomposition (SVD of block recursive matrices of transform matrix, and then transform matrix can be rewritten in a product of two block diagonal matrices and a permutation matrix. Furthermore, we factorize the block matrix of block diagonal matrices into triangular elementary reversible matrices (TERMs, which map integers to integers by rounding arithmetic. The cost of factorizing block matrix into TERMs does not increase with the increase of the dimension of transform matrix, and the proposed algorithm is in-place calculation and without allocating auxiliary memory. Examples of integer multiwavelet transform using DGHM and CL are given, which verify that the proposed algorithm is an executable algorithm and outperforms the existing algorithm for orthogonal 4-tap integer multiwavelet transform.

Half-integer flux quantum effect in cuprate superconductors - a probe of pairing symmetry

International Nuclear Information System (INIS)

Tsuei, C.C.; Kirtley, J.R.; Gupta, A.; Sun, J.Z.; Moler, K.A.; Wang, J.H.

1996-01-01

Based on macroscopic quantum coherence effects arising from pair tunneling and flux quantization, a series of tricrystal experiments have been designed and carried out to test the order parameter symmetry in high-T c cuprate superconductors. By using a scanning SQUID microscope, we have directly and non-invasively observed the spontaneously generated half-integer flux quantum effect in controlled-orientation tricrystal cuprate superconducting systems. The presence or absence of the half-integer flux quantum effect as a function of the tricrystal geometry allows us to prove that the order parameter symmetry in the YBCO and Tl2201 systems is consistent with that of the d x 2 -y 2 pair state. (orig.)

Spreading Sequences Generated Using Asymmetrical Integer-Number Maps

Directory of Open Access Journals (Sweden)

V. Sebesta

2007-09-01

Full Text Available Chaotic sequences produced by piecewise linear maps can be transformed to binary sequences. The binary sequences are optimal for the asynchronous DS/CDMA systems in case of certain shapes of the maps. This paper is devoted to the one-to-one integer-number maps derived from the suitable asymmetrical piecewise linear maps. Such maps give periodic integer-number sequences, which can be transformed to the binary sequences. The binary sequences produced via proposed modified integer-number maps are perfectly balanced and embody good autocorrelation and crosscorrelation properties. The number of different binary sequences is sizable. The sequences are suitable as spreading sequences in DS/CDMA systems.

Integer-valued time series

NARCIS (Netherlands)

van den Akker, R.

2007-01-01

This thesis adresses statistical problems in econometrics. The first part contributes statistical methodology for nonnegative integer-valued time series. The second part of this thesis discusses semiparametric estimation in copula models and develops semiparametric lower bounds for a large class of

Integer programming techniques for educational timetabling

DEFF Research Database (Denmark)

Fonseca, George H.G.; Santos, Haroldo G.; Carrano, Eduardo G.

2017-01-01

in recent studies in the field. This work presents new cuts and reformulations for the existing integer programming model for XHSTT. The proposed cuts improved hugely the linear relaxation of the formulation, leading to an average gap reduction of 32%. Applied to XHSTT-2014 instance set, the alternative...... formulation provided four new best known lower bounds and, used in a matheuristic framework, improved eleven best known solutions. The computational experiments also show that the resulting integer programming models from the proposed formulation are more effectively solved for most of the instances....

Mixed integer evolution strategies for parameter optimization.

Science.gov (United States)

Li, Rui; Emmerich, Michael T M; Eggermont, Jeroen; Bäck, Thomas; Schütz, M; Dijkstra, J; Reiber, J H C

2013-01-01

Evolution strategies (ESs) are powerful probabilistic search and optimization algorithms gleaned from biological evolution theory. They have been successfully applied to a wide range of real world applications. The modern ESs are mainly designed for solving continuous parameter optimization problems. Their ability to adapt the parameters of the multivariate normal distribution used for mutation during the optimization run makes them well suited for this domain. In this article we describe and study mixed integer evolution strategies (MIES), which are natural extensions of ES for mixed integer optimization problems. MIES can deal with parameter vectors consisting not only of continuous variables but also with nominal discrete and integer variables. Following the design principles of the canonical evolution strategies, they use specialized mutation operators tailored for the aforementioned mixed parameter classes. For each type of variable, the choice of mutation operators is governed by a natural metric for this variable type, maximal entropy, and symmetry considerations. All distributions used for mutation can be controlled in their shape by means of scaling parameters, allowing self-adaptation to be implemented. After introducing and motivating the conceptual design of the MIES, we study the optimality of the self-adaptation of step sizes and mutation rates on a generalized (weighted) sphere model. Moreover, we prove global convergence of the MIES on a very general class of problems. The remainder of the article is devoted to performance studies on artificial landscapes (barrier functions and mixed integer NK landscapes), and a case study in the optimization of medical image analysis systems. In addition, we show that with proper constraint handling techniques, MIES can also be applied to classical mixed integer nonlinear programming problems.

Efficient Algorithms for gcd and Cubic Residuosity in the Ring of Eisenstein Integers

DEFF Research Database (Denmark)

Damgård, Ivan Bjerre; Frandsen, Gudmund Skovbjerg

2003-01-01

We present simple and efficient algorithms for computing gcd and cubic residuosity in the ring of Eisenstein integers, bf Z[ ]i.e. the integers extended with , a complex primitive third root of unity. The algorithms are similar and may be seen as generalisations of the binary integer gcd and deri......We present simple and efficient algorithms for computing gcd and cubic residuosity in the ring of Eisenstein integers, bf Z[ ]i.e. the integers extended with , a complex primitive third root of unity. The algorithms are similar and may be seen as generalisations of the binary integer gcd...

Spinor Field Realizations of the half-integer $W_{2,s}$ Strings

OpenAIRE

Wei, Shao-Wen; Liu, Yu-Xiao; Zhang, Li-Jie; Ren, Ji-Rong

2008-01-01

The grading Becchi-Rouet-Stora-Tyutin (BRST) method gives a way to construct the integer $W_{2,s}$ strings, where the BRST charge is written as $Q_B=Q_0+Q_1$. Using this method, we reconstruct the nilpotent BRST charges $Q_{0}$ for the integer $W_{2,s}$ strings and the half-integer $W_{2,s}$ strings. Then we construct the exact grading BRST charge with spinor fields and give the new realizations of the half-integer $W_{2,s}$ strings for the cases of $s=3/2$, 5/2, and 7/2.

Non-linear time series extreme events and integer value problems

CERN Document Server

Turkman, Kamil Feridun; Zea Bermudez, Patrícia

2014-01-01

This book offers a useful combination of probabilistic and statistical tools for analyzing nonlinear time series. Key features of the book include a study of the extremal behavior of nonlinear time series and a comprehensive list of nonlinear models that address different aspects of nonlinearity. Several inferential methods, including quasi likelihood methods, sequential Markov Chain Monte Carlo Methods and particle filters, are also included so as to provide an overall view of the available tools for parameter estimation for nonlinear models. A chapter on integer time series models based on several thinning operations, which brings together all recent advances made in this area, is also included. Readers should have attended a prior course on linear time series, and a good grasp of simulation-based inferential methods is recommended. This book offers a valuable resource for second-year graduate students and researchers in statistics and other scientific areas who need a basic understanding of nonlinear time ...

Tectonic setting of the Seychelles, Mascarene and Amirante Plateaus in the Western Equatorial Indian Ocean

International Nuclear Information System (INIS)

Mart, Y.

1988-01-01

A system of marine plateaus occurs in the western equatorial Indian Ocean, forming an arcuate series of wide and shallow banks with small islands in places. The oceanic basins that surround the Seychelles - Amirante region are of various ages and reflect a complex seafloor spreading pattern. The structural analysis of the Seychelle - Amirante - Mascarene region reflects the tectonic evolution of the western equatorial Indian Ocean. It is suggested that due to the seafloor spreading during a tectonic stage, the Seychelles continental block drifted southwestwards to collide with the oceanic crust of the Mascarene Basin, forming an elongated folded structure at first, and then a subduction zone. The morphological similarity, the lithological variability and the different origin of the Seychelles Bank, the Mascarene Plateau and the Amirante Arc emphasizes the significant convergent effects of various plate tectonic processes on the development of marine plateaus

Magnetization plateaus in the spin-1/2 antiferromagnetic Heisenberg model on a kagome-strip chain

Science.gov (United States)

Morita, Katsuhiro; Sugimoto, Takanori; Sota, Shigetoshi; Tohyama, Takami

2018-01-01

The spin-1/2 Heisenberg model on a kagome lattice is a typical frustrated quantum spin system. The basic structure of a kagome lattice is also present in the kagome-strip lattice in one dimension, where a similar type of frustration is expected. We thus study the magnetization plateaus of the spin-1/2 Heisenberg model on a kagome-strip chain with three-independent antiferromagnetic exchange interactions using the density-matrix renormalization-group method. In a certain range of exchange parameters, we find twelve kinds of magnetization plateaus, nine of which have magnetic structures breaking translational and/or reflection symmetry spontaneously. The structures are classified by an array of five-site unit cells with specific bond-spin correlations. In a case with a nontrivial plateau, namely a 3/10 plateau, we find long-period magnetic structure with a period of four unit cells.

Presolving and regularization in mixed-integer second-order cone optimization

DEFF Research Database (Denmark)

Friberg, Henrik Alsing

Mixed-integer second-order cone optimization is a powerful mathematical framework capable of representing both logical conditions and nonlinear relationships in mathematical models of industrial optimization problems. What is more, solution methods are already part of many major commercial solvers...... both continuous and mixed-integer conic optimization in general, is discovered and treated. This part of the thesis continues the studies of facial reduction preceding the work of Borwein and Wolkowicz [17] in 1981, when the first algorithmic cure for these kinds of reliability issues were formulated....... An important distinction to make between continuous and mixed-integer optimization, however, is that the reliability issues occurring in mixed-integer optimization cannot be blamed on the practitioner’s formulation of the problem. Specifically, as shown, the causes for these issues may well lie within...

Conference on Commutative rings, integer-valued polynomials and polynomial functions

CERN Document Server

Frisch, Sophie; Glaz, Sarah; Commutative Algebra : Recent Advances in Commutative Rings, Integer-Valued Polynomials, and Polynomial Functions

2014-01-01

This volume presents a multi-dimensional collection of articles highlighting recent developments in commutative algebra. It also includes an extensive bibliography and lists a substantial number of open problems that point to future directions of research in the represented subfields. The contributions cover areas in commutative algebra that have flourished in the last few decades and are not yet well represented in book form. Highlighted topics and research methods include Noetherian and non- Noetherian ring theory as well as integer-valued polynomials and functions. Specific topics include: ·    Homological dimensions of Prüfer-like rings ·    Quasi complete rings ·    Total graphs of rings ·    Properties of prime ideals over various rings ·    Bases for integer-valued polynomials ·    Boolean subrings ·    The portable property of domains ·    Probabilistic topics in Intn(D) ·    Closure operations in Zariski-Riemann spaces of valuation domains ·    Stability of do...

Influence of non-integer-order derivatives on unsteady unidirectional motions of an Oldroyd-B fluid with generalized boundary conditions

Science.gov (United States)

Zafar, A. A.; Riaz, M. B.; Shah, N. A.; Imran, M. A.

2018-03-01

The objective of this article is to study some unsteady Couette flows of an Oldroyd-B fluid with non-integer derivatives. The fluid fills an annular region of two infinite co-axial circular cylinders. Flows are due to the motion of the outer cylinder, that rotates about its axis with an arbitrary time-dependent velocity while the inner cylinder is held fixed. Closed form solutions of dimensionless velocity field and tangential tension are obtained by means of the finite Hankel transform and the theory of Laplace transform for fractional calculus. Several results in the literature including the rotational flows through an infinite cylinder can be obtained as limiting cases of our general solutions. Finally, the control of the fractional framework on the dynamics of fluid is analyzed by numerical simulations and graphical illustrations.

Modeling Polio Data Using the First Order Non-Negative Integer-Valued Autoregressive, INAR(1), Model

Science.gov (United States)

Vazifedan, Turaj; Shitan, Mahendran

Time series data may consists of counts, such as the number of road accidents, the number of patients in a certain hospital, the number of customers waiting for service at a certain time and etc. When the value of the observations are large it is usual to use Gaussian Autoregressive Moving Average (ARMA) process to model the time series. However if the observed counts are small, it is not appropriate to use ARMA process to model the observed phenomenon. In such cases we need to model the time series data by using Non-Negative Integer valued Autoregressive (INAR) process. The modeling of counts data is based on the binomial thinning operator. In this paper we illustrate the modeling of counts data using the monthly number of Poliomyelitis data in United States between January 1970 until December 1983. We applied the AR(1), Poisson regression model and INAR(1) model and the suitability of these models were assessed by using the Index of Agreement(I.A.). We found that INAR(1) model is more appropriate in the sense it had a better I.A. and it is natural since the data are counts.

Clustering of Cochlear Oscillations in Frequency Plateaus as a Tool to Investigate SOAE Generation

DEFF Research Database (Denmark)

Epp, Bastian; Wit, Hero; van Dijk, Pim

2016-01-01

of coupled oscillators (OAM) [7] are also found in a transmission line model (TLM) which is able to generate realistic SOAEs [2] and if these frequency plateaus can be used to explain the formation of SOAEs. The simulations showed a clustering of oscillators along the simulated basilar membrane Both, the OAM...

IESIP - AN IMPROVED EXPLORATORY SEARCH TECHNIQUE FOR PURE INTEGER LINEAR PROGRAMMING PROBLEMS

Science.gov (United States)

Fogle, F. R.

1994-01-01

IESIP, an Improved Exploratory Search Technique for Pure Integer Linear Programming Problems, addresses the problem of optimizing an objective function of one or more variables subject to a set of confining functions or constraints by a method called discrete optimization or integer programming. Integer programming is based on a specific form of the general linear programming problem in which all variables in the objective function and all variables in the constraints are integers. While more difficult, integer programming is required for accuracy when modeling systems with small numbers of components such as the distribution of goods, machine scheduling, and production scheduling. IESIP establishes a new methodology for solving pure integer programming problems by utilizing a modified version of the univariate exploratory move developed by Robert Hooke and T.A. Jeeves. IESIP also takes some of its technique from the greedy procedure and the idea of unit neighborhoods. A rounding scheme uses the continuous solution found by traditional methods (simplex or other suitable technique) and creates a feasible integer starting point. The Hook and Jeeves exploratory search is modified to accommodate integers and constraints and is then employed to determine an optimal integer solution from the feasible starting solution. The user-friendly IESIP allows for rapid solution of problems up to 10 variables in size (limited by DOS allocation). Sample problems compare IESIP solutions with the traditional branch-and-bound approach. IESIP is written in Borland's TURBO Pascal for IBM PC series computers and compatibles running DOS. Source code and an executable are provided. The main memory requirement for execution is 25K. This program is available on a 5.25 inch 360K MS DOS format diskette. IESIP was developed in 1990. IBM is a trademark of International Business Machines. TURBO Pascal is registered by Borland International.

Rewrite systems for integer arithmetic

NARCIS (Netherlands)

H.R. Walters (Pum); H. Zantema (Hans)

1995-01-01

textabstractWe present three term rewrite systems for integer arithmetic with addition, multiplication, and, in two cases, subtraction. All systems are ground confluent and terminating; termination is proved by semantic labelling and recursive path order. The first system represents numbers by

Rewrite systems for integer arithmetic

NARCIS (Netherlands)

Walters, H.R.; Zantema, H.

1994-01-01

We present three term rewrite systems for integer arithmetic with addition, multiplication, and, in two cases, subtraction. All systems are ground con uent and terminating; termination is proved by semantic labelling and recursive path order. The first system represents numbers by successor and

A few Smarandache Integer Sequences

OpenAIRE

Ibstedt, Henry

2010-01-01

This paper deals with the analysis of a few Smarandache Integer Sequences which first appeared in Properties or the Numbers, F. Smarandache, University or Craiova Archives, 1975. The first four sequences are recurrence generated sequences while the last three are concatenation sequences.

Magnetization plateaus and phase diagrams of the Ising model on the Shastry–Sutherland lattice

Energy Technology Data Exchange (ETDEWEB)

Deviren, Seyma Akkaya, E-mail: sadeviren@nevsehir.edu.tr

2015-11-01

The magnetization properties of a two-dimensional spin-1/2 Ising model on the Shastry–Sutherland lattice are studied within the effective-field theory (EFT) with correlations. The thermal behavior of the magnetizations is investigated in order to characterize the nature (the first- or second-order) of the phase transitions as well as to obtain the phase diagrams of the model. The internal energy, specific heat, entropy and free energy of the system are also examined numerically as a function of the temperature in order to confirm the stability of the phase transitions. The applied field dependence of the magnetizations is also examined to find the existence of the magnetization plateaus. For strong enough magnetic fields, several magnetization plateaus are observed, e.g., at 1/9, 1/8, 1/3 and 1/2 of the saturation. The phase diagrams of the model are constructed in two different planes, namely (h/|J|, |J′|/|J|) and (h/|J|, T/|J|) planes. It was found that the model exhibits first- and second-order phase transitions; hence tricitical point is also observed in additional to the zero-temperature critical point. Moreover the Néel order (N), collinear order (C) and ferromagnetic (F) phases are also found with appropriate values of the system parameters. The reentrant behavior is also obtained whenever model displays two Néel temperatures. These results are compared with some theoretical and experimental works and a good overall agreement has been obtained. - Highlights: • Magnetization properties of spin-1/2 Ising model on SS lattice are investigated. • The magnetization plateaus of the 1/9, 1/8, 1/3 and 1/2 are observed. • The phase diagrams of the model are constructed in two different planes. • The model exhibits the tricitical and zero-temperature critical points. • The reentrant behavior is obtained whenever model displays two Neel temperatures.

A time series model: First-order integer-valued autoregressive (INAR(1))

Science.gov (United States)

Simarmata, D. M.; Novkaniza, F.; Widyaningsih, Y.

2017-07-01

Nonnegative integer-valued time series arises in many applications. A time series model: first-order Integer-valued AutoRegressive (INAR(1)) is constructed by binomial thinning operator to model nonnegative integer-valued time series. INAR (1) depends on one period from the process before. The parameter of the model can be estimated by Conditional Least Squares (CLS). Specification of INAR(1) is following the specification of (AR(1)). Forecasting in INAR(1) uses median or Bayesian forecasting methodology. Median forecasting methodology obtains integer s, which is cumulative density function (CDF) until s, is more than or equal to 0.5. Bayesian forecasting methodology forecasts h-step-ahead of generating the parameter of the model and parameter of innovation term using Adaptive Rejection Metropolis Sampling within Gibbs sampling (ARMS), then finding the least integer s, where CDF until s is more than or equal to u . u is a value taken from the Uniform(0,1) distribution. INAR(1) is applied on pneumonia case in Penjaringan, Jakarta Utara, January 2008 until April 2016 monthly.

Integers without large prime factors in short intervals: Conditional ...

Indian Academy of Sciences (India)

α > 0 the interval (X, X +. √. X(log X)1/2+o(1)] contains an integer having no prime factor exceeding Xα for all X sufficiently large. Keywords. Smooth numbers; Riemann zeta function. 1. Introduction. Suppose P (n) denotes the largest prime factor of an integer n > 1 and let us declare. P(1) = 1. Given a positive real number y, ...

Parallel Integer Factorization Using Quadratic Forms

National Research Council Canada - National Science Library

McMath, Stephen S

2005-01-01

Factorization is important for both practical and theoretical reasons. In secure digital communication, security of the commonly used RSA public key cryptosystem depends on the difficulty of factoring large integers...

Optimal Diet Planning for Eczema Patient Using Integer Programming

Science.gov (United States)

Zhen Sheng, Low; Sufahani, Suliadi

2018-04-01

Human diet planning is conducted by choosing appropriate food items that fulfill the nutritional requirements into the diet formulation. This paper discusses the application of integer programming to build the mathematical model of diet planning for eczema patients. The model developed is used to solve the diet problem of eczema patients from young age group. The integer programming is a scientific approach to select suitable food items, which seeks to minimize the costs, under conditions of meeting desired nutrient quantities, avoiding food allergens and getting certain foods into the diet that brings relief to the eczema conditions. This paper illustrates that the integer programming approach able to produce the optimal and feasible solution to deal with the diet problem of eczema patient.

Personality disorders in adopted versus non-adopted adults.

Science.gov (United States)

Westermeyer, Joseph; Yoon, Gihyun; Amundson, Carla; Warwick, Marion; Kuskowski, Michael A

2015-04-30

The goal of this epidemiological study was to investigate lifetime history and odds ratios of personality disorders in adopted and non-adopted adults using a nationally representative sample. Data, drawn from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC), were compared in adopted (n=378) versus non-adopted (n=42,503) adults to estimate the odds of seven personality disorders using logistic regression analyses. The seven personality disorders were histrionic, antisocial, avoidant, paranoid, schizoid, obsessive-compulsive, and dependent personality disorder. Adoptees had a 1.81-fold increase in the odds of any personality disorder compared with non-adoptees. Adoptees had increased odds of histrionic, antisocial, avoidant, paranoid, schizoid, and obsessive-compulsive personality disorder compared with non-adoptees. Two risk factors associated with lifetime history of a personality disorder in adoptees compared to non-adoptees were (1) being in the age cohort 18-29 years (but no difference in the age 30-44 cohort), using the age 45 or older cohort as the reference and (2) having 12 years of education (but no difference in higher education groups), using the 0-11 years of education as the reference. These findings support the higher rates of personality disorders among adoptees compared to non-adoptees. Published by Elsevier Ireland Ltd.

A new algorithm for benchmarking in integer data envelopment analysis

Directory of Open Access Journals (Sweden)

M. M. Omran

2012-08-01

Full Text Available The aim of this study is to investigate the effect of integer data in data envelopment analysis (DEA. The inputs and outputs in different types of DEA are considered to be continuous. In most application-oriented problems, some or all data are integers; and subsequently, the continuous condition of the values is omitted. For example, situations in which the inputs/outputs are representatives of the number of cars, people, etc. In fact, the benchmark unit is artificial and does not contain integer inputs/outputs after projection on the efficiency frontier. By rounding off the projection point, we may lose the feasibility or end up having inefficient DMU. In such cases, it is required to provide a benchmark unit such that the considered unit reaches the efficiency. In the present short communication, by proposing a novel algorithm, the projecting of an inefficient DMU is carried out in such a way that produced benchmarking takes values with fully integer inputs/outputs.

Impurity-generated non-Abelions

Science.gov (United States)

Simion, G.; Kazakov, A.; Rokhinson, L. P.; Wojtowicz, T.; Lyanda-Geller, Y. B.

2018-06-01

Two classes of topological superconductors and Majorana modes in condensed matter systems are known to date: one in which disorder induced by impurities strongly suppresses topological superconducting gap and is detrimental to Majorana modes, and another where Majorana fermions are protected by a disorder-robust topological superconductor gap. Observation and control of Majorana fermions and other non-Abelions often requires a symmetry of an underlying system leading to a gap in the single-particle or quasiparticle spectra. In semiconductor structures, impurities that provide charge carriers introduce states into the gap and enable conductance and proximity-induced superconductivity via the in-gap states. Thus a third class of topological superconductivity and Majorana modes emerges, in which topological superconductivity and Majorana fermions appear exclusively when impurities generate in-gap states. We show that impurity-enabled topological superconductivity is realized in a quantum Hall ferromagnet, when a helical domain wall is coupled to an s -wave superconductor. As an example of emergence of topological superconductivity in quantum Hall ferromagnets, we consider the integer quantum Hall effect in Mn-doped CdTe quantum wells. Recent experiments on transport through the quantum Hall ferromagnet domain wall in this system indicated a vital role of impurities in the conductance, but left unresolved the question whether impurities preclude generation of Majorana fermions and other non-Abelions in such systems in general. Here, solving a general quantum-mechanical problem of impurity bound states in a system of spin-orbit coupled Landau levels, we demonstrate that impurity-induced Majorana modes emerge at boundaries between topological and conventional superconducting states generated in a domain wall due to proximity to an s superconductor. We consider both short-range disorder and a smooth random potential. The phase diagram of the system is defined by

Environmental and hydrologic setting of the Ozark Plateaus study unit, Arkansas, Kansas, Missouri, and Oklahoma

Science.gov (United States)

Adamski, James C.; Petersen, James C.; Freiwald, David A.; Davis, Jerri V.

1995-01-01

The environmental and hydrologic setting of the Ozark Plateaus National Water-Quality Assessment (NAWQA) study unit and the factors that affect water quality are described in this report. The primary natural and cultural features that affect water- quality characteristics and the potential for future water-quality problems are described. These environmental features include climate, physio- graphy, geology, soils, population, land use, water use, and surface- and ground-water flow systems. The study-unit area is approximately 47,600 square miles and includes most of the Ozark Plateaus Province and parts of the adjacent Osage Plains and Mississippi Alluvial Plain in parts of Arkansas, Kansas, Missouri, and Oklahoma. The geology is characterized by basement igneous rocks overlain by a thick sequence of dolomites, limestones, sandstones, and shales of Paleozoic age. Land use in the study unit is predominantly pasture and forest in the southeastern part, and pasture and cropland in the northwestern part. All or part of the White, Neosho-lllinois, Osage, Gasconade, Meramec, St. Francis, and Black River Basins are within the study unit. Streams in the Boston Mountains contain the least mineralized water, and those in the Osage Plains contain the most mineralized water. The study unit contains eight hydrogeologic units including three major aquifers--the Springfield Plateau, Ozark, and St. Francois aquifers. Streams and aquifers in the study unit generally contain calcium or calcium-magnesium bicarbonate waters. Ground- and surface-water interactions are greatest in the Salem and Springfield Plateaus and least in the Boston Mountains and Osage Plains. Geology, land use, and population probably are the most important environmental factors that affect water quality.

Stochastic programming with integer recourse

NARCIS (Netherlands)

van der Vlerk, Maarten Hendrikus

1995-01-01

In this thesis we consider two-stage stochastic linear programming models with integer recourse. Such models are at the intersection of two different branches of mathematical programming. On the one hand some of the model parameters are random, which places the problem in the field of stochastic

Ramsey theory on the integers

CERN Document Server

Landman, Bruce M

2014-01-01

Ramsey theory is the study of the structure of mathematical objects that is preserved under partitions. In its full generality, Ramsey theory is quite powerful, but can quickly become complicated. By limiting the focus of this book to Ramsey theory applied to the set of integers, the authors have produced a gentle, but meaningful, introduction to an important and enticing branch of modern mathematics. Ramsey Theory on the Integers offers students a glimpse into the world of mathematical research and the opportunity for them to begin pondering unsolved problems. For this new edition, several sections have been added and others have been significantly updated. Among the newly introduced topics are: rainbow Ramsey theory, an "inequality" version of Schur's theorem, monochromatic solutions of recurrence relations, Ramsey results involving both sums and products, monochromatic sets avoiding certain differences, Ramsey properties for polynomial progressions, generalizations of the Erdős-Ginzberg-Ziv theorem, and t...

Suppression of tunneling by interference in half-integer--spin particles

OpenAIRE

Loss, Daniel; DiVincenzo, David P.; Grinstein, G.

1992-01-01

Within a wide class of ferromagnetic and antiferromagnetic systems, quantum tunneling of magnetization direction is spin-parity dependent: it vanishes for magnetic particles with half-integer spin, but is allowed for integer spin. A coherent-state path integral calculation shows that this topological effect results from interference between tunneling paths.

Using Integer Clocks to Verify the Timing-Sync Sensor Network Protocol

Science.gov (United States)

Huang, Xiaowan; Singh, Anu; Smolka, Scott A.

2010-01-01

We use the UPPAAL model checker for Timed Automata to verify the Timing-Sync time-synchronization protocol for sensor networks (TPSN). The TPSN protocol seeks to provide network-wide synchronization of the distributed clocks in a sensor network. Clock-synchronization algorithms for sensor networks such as TPSN must be able to perform arithmetic on clock values to calculate clock drift and network propagation delays. They must be able to read the value of a local clock and assign it to another local clock. Such operations are not directly supported by the theory of Timed Automata. To overcome this formal-modeling obstacle, we augment the UPPAAL specification language with the integer clock derived type. Integer clocks, which are essentially integer variables that are periodically incremented by a global pulse generator, greatly facilitate the encoding of the operations required to synchronize clocks as in the TPSN protocol. With this integer-clock-based model of TPSN in hand, we use UPPAAL to verify that the protocol achieves network-wide time synchronization and is devoid of deadlock. We also use the UPPAAL Tracer tool to illustrate how integer clocks can be used to capture clock drift and resynchronization during protocol execution

Seasonal affective disorder and non-seasonal affective disorders : Results from the NESDA study

NARCIS (Netherlands)

Winthorst, Wim H; Roest, Annelieke M; Bos, Elisabeth H; Meesters, Ybe; Penninx, Brenda W J H; Nolen, Willem A; de Jonge, Peter

BACKGROUND: Seasonal affective disorder (SAD) is considered to be a subtype of depression. AIMS: To compare the clinical picture of SAD to non-seasonal affective disorders (non-SADs). METHOD: Diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) were established

Extension of the Poincaré group with half-integer spin generators: hypergravity and beyond

Energy Technology Data Exchange (ETDEWEB)

Fuentealba, Oscar [Centro de Estudios Científicos (CECs), Av. Arturo Prat 514, Valdivia (Chile); Departamento de Física, Universidad de Concepción, Casilla 160-C, Concepción (Chile); Matulich, Javier; Troncoso, Ricardo [Centro de Estudios Científicos (CECs), Av. Arturo Prat 514, Valdivia (Chile)

2015-09-01

An extension of the Poincaré group with half-integer spin generators is explicitly constructed. We start discussing the case of three spacetime dimensions, and as an application, it is shown that hypergravity can be formulated so as to incorporate this structure as its local gauge symmetry. Since the algebra admits a nontrivial Casimir operator, the theory can be described in terms of gauge fields associated to the extension of the Poincaré group with a Chern-Simons action. The algebra is also shown to admit an infinite-dimensional non-linear extension, that in the case of fermionic spin-3/2 generators, corresponds to a subset of a contraction of two copies of WB{sub 2}. Finally, we show how the Poincaré group can be extended with half-integer spin generators for d≥3 dimensions.

Deterministic integer multiple firing depending on initial state in Wang model

Energy Technology Data Exchange (ETDEWEB)

Xie Yong [Institute of Nonlinear Dynamics, MSSV, Department of Engineering Mechanics, Xi' an Jiaotong University, Xi' an 710049 (China)]. E-mail: yxie@mail.xjtu.edu.cn; Xu Jianxue [Institute of Nonlinear Dynamics, MSSV, Department of Engineering Mechanics, Xi' an Jiaotong University, Xi' an 710049 (China); Jiang Jun [Institute of Nonlinear Dynamics, MSSV, Department of Engineering Mechanics, Xi' an Jiaotong University, Xi' an 710049 (China)

2006-12-15

We investigate numerically dynamical behaviour of the Wang model, which describes the rhythmic activities of thalamic relay neurons. The model neuron exhibits Type I excitability from a global view, but Type II excitability from a local view. There exists a narrow range of bistability, in which a subthreshold oscillation and a suprathreshold firing behaviour coexist. A special firing pattern, integer multiple firing can be found in the certain part of the bistable range. The characteristic feature of such firing pattern is that the histogram of interspike intervals has a multipeaked structure, and the peaks are located at about integer multiples of a basic interspike interval. Since the Wang model is noise-free, the integer multiple firing is a deterministic firing pattern. The existence of bistability leads to the deterministic integer multiple firing depending on the initial state of the model neuron, i.e., the initial values of the state variables.

Deterministic integer multiple firing depending on initial state in Wang model

International Nuclear Information System (INIS)

Xie Yong; Xu Jianxue; Jiang Jun

2006-01-01

We investigate numerically dynamical behaviour of the Wang model, which describes the rhythmic activities of thalamic relay neurons. The model neuron exhibits Type I excitability from a global view, but Type II excitability from a local view. There exists a narrow range of bistability, in which a subthreshold oscillation and a suprathreshold firing behaviour coexist. A special firing pattern, integer multiple firing can be found in the certain part of the bistable range. The characteristic feature of such firing pattern is that the histogram of interspike intervals has a multipeaked structure, and the peaks are located at about integer multiples of a basic interspike interval. Since the Wang model is noise-free, the integer multiple firing is a deterministic firing pattern. The existence of bistability leads to the deterministic integer multiple firing depending on the initial state of the model neuron, i.e., the initial values of the state variables

Performance Analysis for Cooperative Communication System with QC-LDPC Codes Constructed with Integer Sequences

Directory of Open Access Journals (Sweden)

Yan Zhang

2015-01-01

Full Text Available This paper presents four different integer sequences to construct quasi-cyclic low-density parity-check (QC-LDPC codes with mathematical theory. The paper introduces the procedure of the coding principle and coding. Four different integer sequences constructing QC-LDPC code are compared with LDPC codes by using PEG algorithm, array codes, and the Mackey codes, respectively. Then, the integer sequence QC-LDPC codes are used in coded cooperative communication. Simulation results show that the integer sequence constructed QC-LDPC codes are effective, and overall performance is better than that of other types of LDPC codes in the coded cooperative communication. The performance of Dayan integer sequence constructed QC-LDPC is the most excellent performance.

Searching for optimal integer solutions to set partitioning problems using column generation

OpenAIRE

Bredström, David; Jörnsten, Kurt; Rönnqvist, Mikael

2007-01-01

We describe a new approach to produce integer feasible columns to a set partitioning problem directly in solving the linear programming (LP) relaxation using column generation. Traditionally, column generation is aimed to solve the LP relaxation as quick as possible without any concern of the integer properties of the columns formed. In our approach we aim to generate the columns forming the optimal integer solution while simultaneously solving the LP relaxation. By this we can re...

Sabrewing: A lightweight architecture for combined floating-point and integer arithmetic

NARCIS (Netherlands)

Bruintjes, Tom; Walters, K.H.G.; Gerez, Sabih H.; Molenkamp, Egbert; Smit, Gerardus Johannes Maria

In spite of the fact that floating-point arithmetic is costly in terms of silicon area, the joint design of hardware for floating-point and integer arithmetic is seldom considered. While components like multipliers and adders can potentially be shared, floating-point and integer units in

Reversible Integer Wavelet Transform for the Joint of Image Encryption and Watermarking

Directory of Open Access Journals (Sweden)

Bin Wang

2015-01-01

Full Text Available In recent years, signal processing in the encrypted domain has attracted considerable research interest, especially embedding watermarking in encrypted image. In this work, a novel joint of image encryption and watermarking based on reversible integer wavelet transform is proposed. Firstly, the plain-image is encrypted by chaotic maps and reversible integer wavelet transform. Then the lossless watermarking is embedded in the encrypted image by reversible integer wavelet transform and histogram modification. Finally an encrypted image containing watermarking is obtained by the inverse integer wavelet transform. What is more, the original image and watermarking can be completely recovered by inverse process. Numerical experimental results and comparing with previous works show that the proposed scheme possesses higher security and embedding capacity than previous works. It is suitable for protecting the image information.

Density Functional Simulation of a Breaking Nanowire

DEFF Research Database (Denmark)

Nakamura, A.; Brandbyge, Mads; Hansen, Lars Bruno

1999-01-01

to a specific number of eigenchannels. The transitions between plateaus can be abrupt in connection with structural rearrangements or extend over a few a of elongation. The interplay between conductance modes and structural deformation is discussed by means of the eigenchannel transmission probabilities.......We study the deformation and breaking of an atomic-sized sodium wire using density functional simulations. The wire deforms through sudden atomic rearrangements and smoother atomic displacements. The conductance of the wire exhibits plateaus at integer values in units of 2e(2)/h corresponding...

Adaptive generalized function matrix projective lag synchronization between fractional-order and integer-order complex networks with delayed coupling and different dimensions

International Nuclear Information System (INIS)

Dai, Hao; Si, Gangquan; Jia, Lixin; Zhang, Yanbin

2013-01-01

This paper investigates generalized function matrix projective lag synchronization between fractional-order and integer-order complex networks with delayed coupling, non-identical topological structures and different dimensions. Based on Lyapunov stability theory, generalized function matrix projective lag synchronization criteria are derived by using the adaptive control method. In addition, the three-dimensional fractional-order chaotic system and the four-dimensional integer-order hyperchaotic system as the nodes of the drive and the response networks, respectively, are analyzed in detail, and numerical simulation results are presented to illustrate the effectiveness of the theoretical results. (paper)

NON-INFECTIOUS DISORDERS OF WARMWATER FISHES

Science.gov (United States)

Compared with infectious diseases and disorders, few non-infectious diseases and disorders in cultured fish have severe biologic or economic impact. Culture practices, however, often establish environments that promote infectious disease by weakening the immune response or by pro...

Stochastic integer programming by dynamic programming

NARCIS (Netherlands)

Lageweg, B.J.; Lenstra, J.K.; Rinnooy Kan, A.H.G.; Stougie, L.; Ermoliev, Yu.; Wets, R.J.B.

1988-01-01

Stochastic integer programming is a suitable tool for modeling hierarchical decision situations with combinatorial features. In continuation of our work on the design and analysis of heuristics for such problems, we now try to find optimal solutions. Dynamic programming techniques can be used to

Quantum pumping induced by disorder in one dimension

Energy Technology Data Exchange (ETDEWEB)

Qin, Jihong [Department of Physics, University of Science and Technology Beijing, Beijing 100083 (China); Guo, Huaiming, E-mail: hmguo@buaa.edu.cn [Department of Physics, Beihang University, Beijing 100191 (China)

2016-07-01

The topological property in one dimension is protected by symmetry. Based on a concrete model, we study the effect of disorder preserving or breaking the symmetry and show the nature of symmetry protecting in the one dimensional topological phase. A stable quantum pumping can be constructed within the topological model. It is shown that an integer charge is pumped across a periodic chain in a cyclic process. Furthermore we find that not only the quantum pumping is stable to on-site disorder, but also can be induced by it. These results may be realized experimentally using quasicrystals. - Highlights: • We study the effect of disorder preserving or breaking the symmetry. • We show that an integer charge is pumped across a periodic chain in a cyclic process. • Not only the quantum pumping is stable to on-site disorder, but also can be induced by it.

Quantifying widespread aqueous surface weathering on Mars: The plateaus south of Coprates Chasma

Science.gov (United States)

Loizeau, D.; Quantin-Nataf, C.; Carter, J.; Flahaut, J.; Thollot, P.; Lozac'h, L.; Millot, C.

2018-03-01

Pedogenesis has been previously proposed on the plateaus around Coprates Chasma, Valles Marineris to explain the presence of widespread clay sequences with Al-clays and possible hydrated silica over Fe/Mg-clays on the surface of the plateaus (Le Deit et al., 2012; Carter et al., 2015). We use previous observations together with new MRO targeted observations and DEMs to constrain the extent and thickness of the plateau clay unit: the Al-clay unit is less than 3 m thick, likely ∼1 m, while the Fe/Mg-clays underneath are few tens of meters thick. We also refine the age of alteration by retrieving crater retention ages of the altered plateau and of later deposits: the observed clay sequence was created by surface pedogenesis between model ages of 4.1 Ga and 3.75 Ga. Using a leaching model from Zolotov and Mironenko (2016), we estimate the quantity of atmospheric precipitations needed to create such a clay sequence, that strongly depends on the chemistry of the precipitating fluid. A few hundreds of meters of cumulated precipitations of highly acidic fluids could explain the observed clay sequence, consistent with estimates based on late Noachian valley erosion for example (Rosenberg and Head, 2015). We show finally that the maximum quantity of sulfates potentially formed during this surface weathering event can only contribute minimally to the volume of sulfates deposited in Valles Marineris.

Population transfer HMQC for half-integer quadrupolar nuclei

International Nuclear Information System (INIS)

Wang, Qiang; Xu, Jun; Feng, Ningdong; Deng, Feng; Li, Yixuan; Trébosc, Julien; Lafon, Olivier; Hu, Bingwen; Chen, Qun; Amoureux, Jean-Paul

2015-01-01

This work presents a detailed analysis of a recently proposed nuclear magnetic resonance method [Wang et al., Chem. Commun. 49(59), 6653-6655 (2013)] for accelerating heteronuclear coherence transfers involving half-integer spin quadrupolar nuclei by manipulating their satellite transitions. This method, called Population Transfer Heteronuclear Multiple Quantum Correlation (PT-HMQC), is investigated in details by combining theoretical analyses, numerical simulations, and experimental investigations. We find that compared to instant inversion or instant saturation, continuous saturation is the most practical strategy to accelerate coherence transfers on half-integer quadrupolar nuclei. We further demonstrate that this strategy is efficient to enhance the sensitivity of J-mediated heteronuclear correlation experiments between two half-integer quadrupolar isotopes (e.g., 27 Al- 17 O). In this case, the build-up is strongly affected by relaxation for small T 2 ′ and J coupling values, and shortening the mixing time makes a huge signal enhancement. Moreover, this concept of population transfer can also be applied to dipolar-mediated HMQC experiments. Indeed, on the AlPO 4 -14 sample, one still observes experimentally a 2-fold shortening of the optimum mixing time albeit with no significant signal gain in the 31 P-( 27 Al) experiments

Edge states and integer quantum Hall effect in topological insulator thin films.

Science.gov (United States)

Zhang, Song-Bo; Lu, Hai-Zhou; Shen, Shun-Qing

2015-08-25

The integer quantum Hall effect is a topological state of quantum matter in two dimensions, and has recently been observed in three-dimensional topological insulator thin films. Here we study the Landau levels and edge states of surface Dirac fermions in topological insulators under strong magnetic field. We examine the formation of the quantum plateaux of the Hall conductance and find two different patterns, in one pattern the filling number covers all integers while only odd integers in the other. We focus on the quantum plateau closest to zero energy and demonstrate the breakdown of the quantum spin Hall effect resulting from structure inversion asymmetry. The phase diagrams of the quantum Hall states are presented as functions of magnetic field, gate voltage and chemical potential. This work establishes an intuitive picture of the edge states to understand the integer quantum Hall effect for Dirac electrons in topological insulator thin films.

Network interdiction and stochastic integer programming

CERN Document Server

2003-01-01

On March 15, 2002 we held a workshop on network interdiction and the more general problem of stochastic mixed integer programming at the University of California, Davis. Jesús De Loera and I co-chaired the event, which included presentations of on-going research and discussion. At the workshop, we decided to produce a volume of timely work on the topics. This volume is the result. Each chapter represents state-of-the-art research and all of them were refereed by leading investigators in the respective fields. Problems - sociated with protecting and attacking computer, transportation, and social networks gain importance as the world becomes more dep- dent on interconnected systems. Optimization models that address the stochastic nature of these problems are an important part of the research agenda. This work relies on recent efforts to provide methods for - dressing stochastic mixed integer programs. The book is organized with interdiction papers first and the stochastic programming papers in the second part....

Logic integer programming models for signaling networks.

Science.gov (United States)

Haus, Utz-Uwe; Niermann, Kathrin; Truemper, Klaus; Weismantel, Robert

2009-05-01

We propose a static and a dynamic approach to model biological signaling networks, and show how each can be used to answer relevant biological questions. For this, we use the two different mathematical tools of Propositional Logic and Integer Programming. The power of discrete mathematics for handling qualitative as well as quantitative data has so far not been exploited in molecular biology, which is mostly driven by experimental research, relying on first-order or statistical models. The arising logic statements and integer programs are analyzed and can be solved with standard software. For a restricted class of problems the logic models reduce to a polynomial-time solvable satisfiability algorithm. Additionally, a more dynamic model enables enumeration of possible time resolutions in poly-logarithmic time. Computational experiments are included.

Are oceanic plateaus sites of komatiite formation?

Science.gov (United States)

Storey, M.; Mahoney, J. J.; Kroenke, L. W.; Saunders, A. D.

1991-04-01

During Cretaceous and Tertiary time a series of oceanic terranes were accreted onto the Pacific continental margin of Colombia. The island of Gorgona is thought to represent part of the most recent, early Eocene, terrane-forming event. Gorgona is remarkable for the occurrence of komatiites of middle Cretaceous age, having MgO contents up to 24%. The geochemistry of spatially and temporally associated tholeiites suggests that Gorgona is an obducted fragment of the oceanic Caribbean Plateau, postulated by Duncan and Hargraves (1984) to have formed at 100 to 75 Ma over the Galapagos hotspot. Further examples of high-MgO oceanic lavas that may represent fragments of the Caribbean Plateau occur in allochthonous terranes on the island of Curaçao in the Netherlands Antilles and in the Romeral zone ophiolites in the southwestern Colombian Andes. These and other examples suggest that the formation of high-MgO liquids may be a feature of oceanic-plateau settings. The association of Phanerozoic komatiites with oceanic plateaus, coupled with thermal considerations, provides a plausible analogue for the origin of some komatiite-tholeiite sequences in Archean greenstone belts.

Using Integer Programming for Airport Service Planning in Staff Scheduling

Directory of Open Access Journals (Sweden)

W.H. Ip

2010-09-01

Full Text Available Reliability and safety in flight is extremely necessary and that depend on the adoption of proper maintenance system. Therefore, it is essential for aircraft maintenance companies to perform the manpower scheduling efficiently. One of the objectives of this paper is to provide an Integer Programming approach to determine the optimal solutions to aircraft maintenance planning and scheduling and hence the planning and scheduling processes can become more efficient and effective. Another objective is to develop a set of computational schedules for maintenance manpower to cover all scheduled flights. In this paper, a sequential methodology consisting of 3 stages is proposed. They are initial maintenance demand schedule, the maintenance pairing and the maintenance group(s assignment. Since scheduling would split up into different stages, different mathematical techniques have been adopted to cater for their own problem characteristics. Microsoft Excel would be used. Results from the first stage and second stage would be inputted into integer programming model using Microsoft Excel Solver to find the optimal solution. Also, Microsoft Excel VBA is used for devising a scheduling system in order to reduce the manual process and provide a user friendly interface. For the results, all can be obtained optimal solution and the computation time is reasonable and acceptable. Besides, the comparison of the peak time and non-peak time is discussed.

2014/2015 Investigations of the Ontong Java and Kerguelen Plateaus

Science.gov (United States)

Coffin, M. F.; Whittaker, J. M.

2013-12-01

The two largest oceanic plateaus, Ontong Java in the western Pacific, and Kerguelen in the southern Indian Ocean, will be the focus of scheduled multidisciplinary/interdisciplinary shipboard expeditions in 2014 and 2015. In mid-2014, scientists aboard the Schmidt Ocean Institute's RV Falkor will investigate the origin and evolution of two large atolls, Ontong Java and Nukumanu, surmounting the ca 122 Ma Ontong Java Plateau, as well how Kroenke Canyon, which deeply incises the plateau, formed and evolved. First-ever multibeam bathymetry and sub-bottom profiling data from the atolls and canyon will reveal their submarine and shallow sub-seafloor morphology, and, if combined with geochemical and geochronological analyses of potential igneous basement samples, will yield important information on their origin and evolution. The primary goals of this atoll and canyon project are: to test potential genetic relationships between a) the atolls and the OJP, and b) the atolls and Kroenke Canyon; to understand and model how atolls and canyons form and evolve on oceanic plateaus, isolated from terrestrial influences and subject to sea level fluctuations; and to contribute to understanding tsunami risk on low-lying atolls. In late 2014 and early 2015, researchers aboard Australia's new Marine National Facility, RV Investigator, will investigate active submarine hotspot volcanism on the Kerguelen Plateau and its consequences. The project's overall aim is to test the hypothesis that hydrothermal activity driven by active submarine magmatism fertilizes surface waters with iron that enhances primary biological productivity. Surmounting the Cretaceous plateau, Heard and McDonald Islands are among the world's most active hotspot volcanoes, and new multibeam bathymetry and sub-bottom profiling data will enable identification of candidate active submarine volcanoes, which we will sample. In the overlying water column, we will collect samples to test for the presence or absence of

A note on number fields having reciprocal integer generators | Zaïmi ...

African Journals Online (AJOL)

We prove that a totally complex algebraic number field K; having a conjugate which is not closed under complex conjugation, can be generated by a reciprocal integer, when the Galois group of its normal closure is contained in the hyperoctahedral group Bdeg(K)/2. Keywords: Reciprocal integers, unit primitive elements, ...

Predecessor queries in dynamic integer sets

DEFF Research Database (Denmark)

Brodal, Gerth Stølting

1997-01-01

We consider the problem of maintaining a set of n integers in the range 0.2w–1 under the operations of insertion, deletion, predecessor queries, minimum queries and maximum queries on a unit cost RAM with word size w bits. Let f (n) be an arbitrary nondecreasing smooth function satisfying n...

Nonlinear feedback synchronisation control between fractional-order and integer-order chaotic systems

International Nuclear Information System (INIS)

Jia Li-Xin; Dai Hao; Hui Meng

2010-01-01

This paper focuses on the synchronisation between fractional-order and integer-order chaotic systems. Based on Lyapunov stability theory and numerical differentiation, a nonlinear feedback controller is obtained to achieve the synchronisation between fractional-order and integer-order chaotic systems. Numerical simulation results are presented to illustrate the effectiveness of this method

Mixed-integer representations in control design mathematical foundations and applications

CERN Document Server

Prodan, Ionela; Olaru, Sorin; Niculescu, Silviu-Iulian

2016-01-01

In this book, the authors propose efficient characterizations of the non-convex regions that appear in many control problems, such as those involving collision/obstacle avoidance and, in a broader sense, in the description of feasible sets for optimization-based control design involving contradictory objectives. The text deals with a large class of systems that require the solution of appropriate optimization problems over a feasible region, which is neither convex nor compact. The proposed approach uses the combinatorial notion of hyperplane arrangement, partitioning the space by a finite collection of hyperplanes, to describe non-convex regions efficiently. Mixed-integer programming techniques are then applied to propose acceptable formulations of the overall problem. Multiple constructions may arise from the same initial problem, and their complexity under various parameters - space dimension, number of binary variables, etc. - is also discussed. This book is a useful tool for academic researchers and grad...

Linear Independence of -Logarithms over the Eisenstein Integers

Directory of Open Access Journals (Sweden)

Peter Bundschuh

2010-01-01

Full Text Available For fixed complex with ||>1, the -logarithm is the meromorphic continuation of the series ∑>0/(−1,||1,≠,2,3,…. In 2004, Tachiya showed that this is true in the Subcase =ℚ, ∈ℤ, =−1, and the present authors extended this result to arbitrary integer from an imaginary quadratic number field , and provided a quantitative version. In this paper, the earlier method, in particular its arithmetical part, is further developed to answer the above question in the affirmative if is the Eisenstein number field √ℚ(−3, an integer from , and a primitive third root of unity. Under these conditions, the linear independence holds also for 1,(,(−1, and both results are quantitative.

A quadratic approximation-based algorithm for the solution of multiparametric mixed-integer nonlinear programming problems

KAUST Repository

Domínguez, Luis F.

2012-06-25

An algorithm for the solution of convex multiparametric mixed-integer nonlinear programming problems arising in process engineering problems under uncertainty is introduced. The proposed algorithm iterates between a multiparametric nonlinear programming subproblem and a mixed-integer nonlinear programming subproblem to provide a series of parametric upper and lower bounds. The primal subproblem is formulated by fixing the integer variables and solved through a series of multiparametric quadratic programming (mp-QP) problems based on quadratic approximations of the objective function, while the deterministic master subproblem is formulated so as to provide feasible integer solutions for the next primal subproblem. To reduce the computational effort when infeasibilities are encountered at the vertices of the critical regions (CRs) generated by the primal subproblem, a simplicial approximation approach is used to obtain CRs that are feasible at each of their vertices. The algorithm terminates when there does not exist an integer solution that is better than the one previously used by the primal problem. Through a series of examples, the proposed algorithm is compared with a multiparametric mixed-integer outer approximation (mp-MIOA) algorithm to demonstrate its computational advantages. © 2012 American Institute of Chemical Engineers (AIChE).

Hierarchical Hidden Markov Models for Multivariate Integer-Valued Time-Series

DEFF Research Database (Denmark)

Catania, Leopoldo; Di Mari, Roberto

2018-01-01

We propose a new flexible dynamic model for multivariate nonnegative integer-valued time-series. Observations are assumed to depend on the realization of two additional unobserved integer-valued stochastic variables which control for the time-and cross-dependence of the data. An Expectation......-Maximization algorithm for maximum likelihood estimation of the model's parameters is derived. We provide conditional and unconditional (cross)-moments implied by the model, as well as the limiting distribution of the series. A Monte Carlo experiment investigates the finite sample properties of our estimation...

Integer factoring and modular square roots

Czech Academy of Sciences Publication Activity Database

Jeřábek, Emil

2016-01-01

Roč. 82, č. 2 (2016), s. 380-394 ISSN 0022-0000 R&D Projects: GA AV ČR IAA100190902; GA ČR GBP202/12/G061 Institutional support: RVO:67985840 Keywords : integer factoring * quadratic residue * PPA Subject RIV: BA - General Mathematics Impact factor: 1.678, year: 2016 http://www.sciencedirect.com/science/article/pii/S0022000015000768

Obstacles and Affordances for Integer Reasoning: An Analysis of Children's Thinking and the History of Mathematics

Science.gov (United States)

Bishop, Jessica Pierson; Lamb, Lisa L.; Philipp, Randolph A.; Whitacre, Ian; Schappelle, Bonnie P.; Lewis, Melinda L.

2014-01-01

We identify and document 3 cognitive obstacles, 3 cognitive affordances, and 1 type of integer understanding that can function as either an obstacle or affordance for learners while they extend their numeric domains from whole numbers to include negative integers. In particular, we highlight 2 key subsets of integer reasoning: understanding or…

A quantum architecture for multiplying signed integers

International Nuclear Information System (INIS)

Alvarez-Sanchez, J J; Alvarez-Bravo, J V; Nieto, L M

2008-01-01

A new quantum architecture for multiplying signed integers is presented based on Booth's algorithm, which is well known in classical computation. It is shown how a quantum binary chain might be encoded by its flank changes, giving the final product in 2's-complement representation.

Non-Gaussian diffusion in static disordered media

Science.gov (United States)

Luo, Liang; Yi, Ming

2018-04-01

Non-Gaussian diffusion is commonly considered as a result of fluctuating diffusivity, which is correlated in time or in space or both. In this work, we investigate the non-Gaussian diffusion in static disordered media via a quenched trap model, where the diffusivity is spatially correlated. Several unique effects due to quenched disorder are reported. We analytically estimate the diffusion coefficient Ddis and its fluctuation over samples of finite size. We show a mechanism of population splitting in the non-Gaussian diffusion. It results in a sharp peak in the distribution of displacement P (x ,t ) around x =0 , that has frequently been observed in experiments. We examine the fidelity of the coarse-grained diffusion map, which is reconstructed from particle trajectories. Finally, we propose a procedure to estimate the correlation length in static disordered environments, where the information stored in the sample-to-sample fluctuation has been utilized.

THE PHENOMENON OF HALF-INTEGER SPIN, QUATERNIONS, AND PAULI MATRICES

Directory of Open Access Journals (Sweden)

FERNANDO R. GONZÁLEZ DÍAZ

2017-01-01

Full Text Available In this paper the phenomenon of half-integer spin exemplification Paul AM Dirac made with a pair of scissors, an elastic cord and chair play. Four examples in which the same phenomenon appears and the algebraic structure of quaternions is related to one of the examples are described. Mathematical proof of the phenomenon using known topological and algebraic results are explained. The basic results of algebraic structures are described quaternions H , and an intrinsic relationship with the phenomenon half-integer spin and the Pauli matrices is established.

Optimal Allocation of Static Var Compensator via Mixed Integer Conic Programming

Energy Technology Data Exchange (ETDEWEB)

Zhang, Xiaohu [ORNL; Shi, Di [Global Energy Interconnection Research Institute North America (GEIRI North America), California; Wang, Zhiwei [Global Energy Interconnection Research Institute North America (GEIRI North America), California; Huang, Junhui [Global Energy Interconnection Research Institute North America (GEIRI North America), California; Wang, Xu [Global Energy Interconnection Research Institute North America (GEIRI North America), California; Liu, Guodong [ORNL; Tomsovic, Kevin [University of Tennessee, Knoxville (UTK)

2017-01-01

Shunt FACTS devices, such as, a Static Var Compensator (SVC), are capable of providing local reactive power compensation. They are widely used in the network to reduce the real power loss and improve the voltage profile. This paper proposes a planning model based on mixed integer conic programming (MICP) to optimally allocate SVCs in the transmission network considering load uncertainty. The load uncertainties are represented by a number of scenarios. Reformulation and linearization techniques are utilized to transform the original non-convex model into a convex second order cone programming (SOCP) model. Numerical case studies based on the IEEE 30-bus system demonstrate the effectiveness of the proposed planning model.

Mixed integer (0-1) fractional programming for decision support in paper production industry

NARCIS (Netherlands)

Claassen, G.D.H.

2014-01-01

This paper presents an effective and efficient method for solving a special class of mixed integer fractional programming (FP) problems. We take a classical reformulation approach for continuous FP as a starting point and extend it for solving a more general class of mixed integer (0–1) fractional

An Efficient Integer Coding and Computing Method for Multiscale Time Segment

Directory of Open Access Journals (Sweden)

TONG Xiaochong

2016-12-01

Full Text Available This article focus on the exist problem and status of current time segment coding, proposed a new set of approach about time segment coding: multi-scale time segment integer coding (MTSIC. This approach utilized the tree structure and the sort by size formed among integer, it reflected the relationship among the multi-scale time segments: order, include/contained, intersection, etc., and finally achieved an unity integer coding processing for multi-scale time. On this foundation, this research also studied the computing method for calculating the time relationships of MTSIC, to support an efficient calculation and query based on the time segment, and preliminary discussed the application method and prospect of MTSIC. The test indicated that, the implement of MTSIC is convenient and reliable, and the transformation between it and the traditional method is convenient, it has the very high efficiency in query and calculating.

STUDI PERBANDINGAN PERFORMANCE ALGORITMA HEURISTIK POUR TERHADAP MIXED INTEGER PROGRAMMING DALAM MENYELESAIKAN PENJADWALAN FLOWSHOP

Directory of Open Access Journals (Sweden)

Tessa Vanina Soetanto

2004-01-01

Full Text Available This paper presents a study about new heuristic algorithm performance compared to Mixed Integer Programming (MIP method in solving flowshop scheduling problem to reach minimum makespan. Performance appraisal is based on Efficiency Index (EI, Relative Error (RE and Elapsed Runtime. Abstract in Bahasa Indonesia : Makalah ini menyajikan penelitian tentang performance algoritma heuristik Pour terhadap metode Mixed Integer Programming (MIP dalam menyelesaikan masalah penjadwalan flowshop dengan tujuan meminimalkan makespan. Penilaian performance dilakukan berdasarkan nilai Efficiency Index (EI, Relative Error (RE dan Elapsed Runtime. Kata kunci: flowshop, makespan, algoritma heuristik Pour, Mixed Integer Programming.

The features of ballistic electron transport in a suspended quantum point contact

International Nuclear Information System (INIS)

Shevyrin, A. A.; Budantsev, M. V.; Bakarov, A. K.; Toropov, A. I.; Pogosov, A. G.; Ishutkin, S. V.; Shesterikov, E. V.

2014-01-01

A suspended quantum point contact and the effects of the suspension are investigated by performing identical electrical measurements on the same experimental sample before and after the suspension. In both cases, the sample demonstrates conductance quantization. However, the suspended quantum point contact shows certain features not observed before the suspension, namely, plateaus at the conductance values being non-integer multiples of the conductance quantum, including the “0.7-anomaly.” These features can be attributed to the strengthening of electron-electron interaction because of the electric field confinement within the suspended membrane. Thus, the suspended quantum point contact represents a one-dimensional system with strong electron-electron interaction

Bivium as a Mixed Integer Programming Problem

DEFF Research Database (Denmark)

Borghoff, Julia; Knudsen, Lars Ramkilde; Stolpe, Mathias

2009-01-01

over $GF(2)$ into a combinatorial optimization problem. We convert the Boolean equation system into an equation system over $\\mathbb{R}$ and formulate the problem of finding a $0$-$1$-valued solution for the system as a mixed-integer programming problem. This enables us to make use of several...

Winding numbers in homotopy theory from integers to reals

International Nuclear Information System (INIS)

Mekhfi, M.

1993-07-01

In Homotopy Theory (HT) we define paths on a given topological space. Closed paths prove to be construction elements of a group (the fundamental group) Π 1 and carry charges, the winding numbers. The charges are integers as they indicate how many times closed paths encircle a given hole (or set of holes). Open paths as they are defined in (HT) do not possess any groups structure and as such they are less useful in topology. In the present paper we enlarge the concept of a path in such a way that both types of paths do possess a group structure. In this broad sense we have two fundamental groups the Π i = Z group and the SO(2) group of rotations but the latter has the global property that there is no periodicity in the rotation angle. There is also two charge operators W and W λ whose eigenvalues are either integers or reals depending respectively on the paths being closed or open. Also the SO(2) group and the real charge operator W λ are not independently defined but directly related respectively to the Π i group and to the integer charge operator W. Thus well defined links can be established between seemingly different groups and charges. (author). 3 refs, 1 fig

Metamorphic Testing Integer Overflow Faults of Mission Critical Program: A Case Study

Directory of Open Access Journals (Sweden)

Zhanwei Hui

2013-01-01

Full Text Available For mission critical programs, integer overflow is one of the most dangerous faults. Different testing methods provide several effective ways to detect the defect. However, it is hard to validate the testing outputs, because the oracle of testing is not always available or too expensive to get, unless the program throws an exception obviously. In the present study, the authors conduct a case study, where the authors apply a metamorphic testing (MT method to detect the integer overflow defect and alleviate the oracle problem in testing critical program of Traffic Collision Avoidance System (TCAS. Experimental results show that, in revealing typical integer mutations, compared with traditional safety property testing method, MT with a novel symbolic metamorphic relation is more effective than the traditional method in some cases.

Presence of rapidly degrading permafrost plateaus in south-central Alaska

Science.gov (United States)

Jones, Benjamin M.; Baughman, Carson; Romanovsky, Vladimir E.; Parsekian, Andrew D.; Babcock, Esther; Stephani, Eva; Jones, Miriam C.; Grosse, Guido; Berg, Edward E

2016-01-01

Permafrost presence is determined by a complex interaction of climatic, topographic, and ecological conditions operating over long time scales. In particular, vegetation and organic layer characteristics may act to protect permafrost in regions with a mean annual air temperature (MAAT) above 0 °C. In this study, we document the presence of residual permafrost plateaus in the western Kenai Peninsula lowlands of south-central Alaska, a region with a MAAT of 1.5 ± 1 °C (1981–2010). Continuous ground temperature measurements between 16 September 2012 and 15 September 2015, using calibrated thermistor strings, documented the presence of warm permafrost (−0.04 to −0.08 °C). Field measurements (probing) on several plateau features during the fall of 2015 showed that the depth to the permafrost table averaged 1.48 m but at some locations was as shallow as 0.53 m. Late winter surveys (augering, coring, and GPR) in 2016 showed that the average seasonally frozen ground thickness was 0.45 m, overlying a talik above the permafrost table. Measured permafrost thickness ranged from 0.33 to  >  6.90 m. Manual interpretation of historic aerial photography acquired in 1950 indicates that residual permafrost plateaus covered 920 ha as mapped across portions of four wetland complexes encompassing 4810 ha. However, between 1950 and ca. 2010, permafrost plateau extent decreased by 60.0 %, with lateral feature degradation accounting for 85.0 % of the reduction in area. Permafrost loss on the Kenai Peninsula is likely associated with a warming climate, wildfires that remove the protective forest and organic layer cover, groundwater flow at depth, and lateral heat transfer from wetland surface waters in the summer. Better understanding the resilience and vulnerability of ecosystem-protected permafrost is critical for mapping and predicting future permafrost extent and degradation across all permafrost regions that are currently warming

Integers in number systems with positive and negative quadratic Pisot base

OpenAIRE

Masáková, Zuzana; Vávra, Tomáš

2013-01-01

We consider numeration systems with base $\\beta$ and $-\\beta$, for quadratic Pisot numbers $\\beta$ and focus on comparing the combinatorial structure of the sets $\\Z_\\beta$ and $\\Z_{-\\beta}$ of numbers with integer expansion in base $\\beta$, resp. $-\\beta$. Our main result is the comparison of languages of infinite words $u_\\beta$ and $u_{-\\beta}$ coding the ordering of distances between consecutive $\\beta$- and $(-\\beta)$-integers. It turns out that for a class of roots $\\beta$ of $x^2-mx-m$...

Optimization of Product Instantiation using Integer Programming

NARCIS (Netherlands)

van den Broek, P.M.; Botterweck, Goetz; Jarzabek, Stan; Kishi, Tomoji

2010-01-01

We show that Integer Programming (IP) can be used as an optimization technique for the instantiation of products of feature models. This is done by showing that the constraints of feature models can be written in linear form. As particular IP technique, we use Gomory cutting planes. We have applied

The application of the fall-vector method in decomposition schemes for the solution of integer linear programming problems

International Nuclear Information System (INIS)

Sergienko, I.V.; Golodnikov, A.N.

1984-01-01

This article applies the methods of decompositions, which are used to solve continuous linear problems, to integer and partially integer problems. The fall-vector method is used to solve the obtained coordinate problems. An algorithm of the fall-vector is described. The Kornai-Liptak decomposition principle is used to reduce the integer linear programming problem to integer linear programming problems of a smaller dimension and to a discrete coordinate problem with simple constraints

A fuzzy mixed integer programming for marketing planning

Directory of Open Access Journals (Sweden)

Abolfazl Danaei

2014-03-01

Full Text Available One of the primary concerns to market a product is to find appropriate channel to target customers. The recent advances on information technology have created new products with tremendous opportunities. This paper presents a mixed integer programming technique based on McCarthy's 4PS to locate suitable billboards for marketing newly introduced IPHONE product. The paper considers two types of information including age and income and tries to find the best places such that potential consumers aged 25-35 with high income visit the billboards and the cost of advertisement is minimized. The model is formulated in terms of mixed integer programming and it has been applied for potential customers who live in city of Tabriz, Iran. Using a typical software package, the model detects appropriate places in various parts of the city.

Fabry-Perot Interferometry in the Integer and Fractional Quantum Hall Regimes

Science.gov (United States)

McClure, Douglas; Chang, Willy; Kou, Angela; Marcus, Charles; Pfeiffer, Loren; West, Ken

2011-03-01

We present measurements of electronic Fabry-Perot interferometers in the integer and fractional quantum Hall regimes. Two classes of resistance oscillations may be seen as a function of magnetic field and gate voltage, as we have previously reported. In small interferometers in the integer regime, oscillations of the type associated with Coulomb interaction are ubiquitous, while those consistent with single-particle Aharonov-Bohm interference are seen to co-exist in some configurations. The amplitude scaling of both types with temperature and device size is consistent with a theoretical model. Oscillations are further observed in the fractional quantum Hall regime. Here the dependence of the period on the filling factors in the constrictions and bulk of the interferometer can shed light on the effective charge of the interfering quasiparticles, but care is needed to distinguish these oscillations from those associated with integer quantum Hall states. We acknowledge funding from Microsoft Project Q and IBM.

Mixed Integer Programming and Heuristic Scheduling for Space Communication

Science.gov (United States)

Lee, Charles H.; Cheung, Kar-Ming

2013-01-01

Optimal planning and scheduling for a communication network was created where the nodes within the network are communicating at the highest possible rates while meeting the mission requirements and operational constraints. The planning and scheduling problem was formulated in the framework of Mixed Integer Programming (MIP) to introduce a special penalty function to convert the MIP problem into a continuous optimization problem, and to solve the constrained optimization problem using heuristic optimization. The communication network consists of space and ground assets with the link dynamics between any two assets varying with respect to time, distance, and telecom configurations. One asset could be communicating with another at very high data rates at one time, and at other times, communication is impossible, as the asset could be inaccessible from the network due to planetary occultation. Based on the network's geometric dynamics and link capabilities, the start time, end time, and link configuration of each view period are selected to maximize the communication efficiency within the network. Mathematical formulations for the constrained mixed integer optimization problem were derived, and efficient analytical and numerical techniques were developed to find the optimal solution. By setting up the problem using MIP, the search space for the optimization problem is reduced significantly, thereby speeding up the solution process. The ratio of the dimension of the traditional method over the proposed formulation is approximately an order N (single) to 2*N (arraying), where N is the number of receiving antennas of a node. By introducing a special penalty function, the MIP problem with non-differentiable cost function and nonlinear constraints can be converted into a continuous variable problem, whose solution is possible.

Chirality effect in disordered graphene ribbon junctions

International Nuclear Information System (INIS)

Long Wen

2012-01-01

We investigate the influence of edge chirality on the electronic transport in clean or disordered graphene ribbon junctions. By using the tight-binding model and the Landauer-Büttiker formalism, the junction conductance is obtained. In the clean sample, the zero-magnetic-field junction conductance is strongly chirality-dependent in both unipolar and bipolar ribbons, whereas the high-magnetic-field conductance is either chirality-independent in the unipolar or chirality-dependent in the bipolar ribbon. Furthermore, we study the disordered sample in the presence of magnetic field and find that the junction conductance is always chirality-insensitive for both unipolar and bipolar ribbons with adequate disorders. In addition, the disorder-induced conductance plateaus can exist in all chiral bipolar ribbons provided the disorder strength is moderate. These results suggest that we can neglect the effect of edge chirality in fabricating electronic devices based on the magnetotransport in a disordered graphene ribbon. (paper)

Network Model for The Problem of Integer Balancing of a Fourdimensional Matrix

Directory of Open Access Journals (Sweden)

A. V. Smirnov

2016-01-01

Full Text Available The problem of integer balancing of a four-dimensional matrix is studied. The elements of the inner part (all four indices are greater than zero of the given real matrix are summed in each direction and each two- and three-dimensional section of the matrix; the total sum is also found. These sums are placed into the elements where one or more indices are equal to zero (according to the summing directions. The problem is to find an integer matrix of the same structure, which can be produced from the initial one by replacing the elements with the largest previous or the smallest following integer. At the same time, the element with four zero indices should be produced with standard rules of rounding - off. In the article the problem of finding the maximum multiple flow in the network of any natural multiplicity   is also studied. There are arcs of three types: ordinary arcs, multiple arcs and multi-arcs. Each multiple and multi-arc is a union of   linked arcs, which are adjusted with each other. The network constructing rules are described. The definitions of a divisible network and some associated subjects are stated. There are defined the basic principles for reducing the integer balancing problem of an  -dimensional matrix (  to the problem of finding the maximum flow in a divisible multiple network of multiplicity  . There are stated the rules for reducing the four-dimensional balancing problem to the maximum flow problem in the network of multiplicity 5. The algorithm of finding the maximum flow, which meets the solvability conditions for the integer balancing problem, is formulated for such a network.

Were Oceanic Plateaus Instrumental for Calcareous Nannoplankton Evolution?

Science.gov (United States)

Erba, E.; Casellato, C.; Bottini, C.

2011-12-01

The history of calcareous nannoplankton shows a general increase in species richness through the Mesozoic. Fertility and chemistry of the oceans, climate and pCO2 seem instrumental for nannoplankton abundance, diversification and adaptation, but high-resolution chronology of paleobiological and geological events is crucial for the understanding of evolutionary processes relative to ecosystem perturbations. Natural variations in atmospheric CO2 are essentially triggered by igneous activity and the role of ocean crust production in the evolution of seawater composition, nutrient cycling, climate change and, consequently, in calcareous nannoplankton biodiversity, might be more relevant than generally thought. Indeed, two major steps in nannofloral Mesozoic evolution correlate with construction of gigantic oceanic plateaus, namely the Shatsky Rise (SR) (Tithonian/Berriasian boundary interval) and the Ontong Java Plateau (OJP) (Barremian/Aptian boundary interval). During the latest Jurassic calcareous nannoplankton experienced a rapid diversification and rise in abundance of several taxa including heavily calcified nannoliths with consequent major increase in biogenic calcite production. The Tithonian origination of coccoliths and nannoliths suggests ideal paleoecological conditions for calcareous nannoplankton, presumably thriving in stable, relatively oligotrophic and cool oceans under low pCO2. Recent data indicate that this speciation and calcification episode was interrupted during magnetochron CM19r, prior to massive diversification of nannoconids. In the late Barremian-early Aptian interval, the nannoconid decline and crisis are paralleled by a major nannoplankton (mainly coccolith) speciation episode. Such calcification failure and coccolith diversification might reflect disruption of the thermocline, increased fertility and warming under excess CO2 levels. These evolutionary steps show rapid speciation, but differ because nannoliths became dominant in the late

A Mixed Integer Linear Programming Approach to Electrical Stimulation Optimization Problems.

Science.gov (United States)

Abouelseoud, Gehan; Abouelseoud, Yasmine; Shoukry, Amin; Ismail, Nour; Mekky, Jaidaa

2018-02-01

Electrical stimulation optimization is a challenging problem. Even when a single region is targeted for excitation, the problem remains a constrained multi-objective optimization problem. The constrained nature of the problem results from safety concerns while its multi-objectives originate from the requirement that non-targeted regions should remain unaffected. In this paper, we propose a mixed integer linear programming formulation that can successfully address the challenges facing this problem. Moreover, the proposed framework can conclusively check the feasibility of the stimulation goals. This helps researchers to avoid wasting time trying to achieve goals that are impossible under a chosen stimulation setup. The superiority of the proposed framework over alternative methods is demonstrated through simulation examples.

Non-self-averaging nucleation rate due to quenched disorder

International Nuclear Information System (INIS)

Sear, Richard P

2012-01-01

We study the nucleation of a new thermodynamic phase in the presence of quenched disorder. The quenched disorder is a generic model of both impurities and disordered porous media; both are known to have large effects on nucleation. We find that the nucleation rate is non-self-averaging. This is in a simple Ising model with clusters of quenched spins. We also show that non-self-averaging behaviour is straightforward to detect in experiments, and may be rather common. (fast track communication)

50 Years of Integer Programming 1958-2008 From the Early Years to the State-of-the-Art

CERN Document Server

Jünger, Michael; Naddef, Denis

2010-01-01

In 1958, Ralph E. Gomory transformed the field of integer programming when he published a paper that described a cutting-plane algorithm for pure integer programs and announced that the method could be refined to give a finite algorithm for integer programming. In 2008, to commemorate the anniversary of this seminal paper, a special workshop celebrating fifty years of integer programming was held in Aussois, France, as part of the 12th Combinatorial Optimization Workshop. It contains reprints of key historical articles and written versions of survey lectures on six of the hottest topics in the

Triangular Numbers, Gaussian Integers, and KenKen

Science.gov (United States)

Watkins, John J.

2012-01-01

Latin squares form the basis for the recreational puzzles sudoku and KenKen. In this article we show how useful several ideas from number theory are in solving a KenKen puzzle. For example, the simple notion of triangular number is surprisingly effective. We also introduce a variation of KenKen that uses the Gaussian integers in order to…

Quadratic Sieve integer factorization using Hadoop

OpenAIRE

Ghebregiorgish, Semere Tsehaye

2012-01-01

Master's thesis in Computer Science Integer factorization problem is one of the most important parts in the world of cryptography. The security of the widely-used public-key cryptographic algorithm, RSA [1], and the Blum Blum Shub cryptographic pseudorandom number generator [2] heavily depend on the presumed difficulty of factoring a number to its prime constituents. As the size of the number to be factored gets larger, the difficulty of the problem increases enormously. Thi...

RSM 1.0 - A RESUPPLY SCHEDULER USING INTEGER OPTIMIZATION

Science.gov (United States)

Viterna, L. A.

1994-01-01

RSM, Resupply Scheduling Modeler, is a fully menu-driven program that uses integer programming techniques to determine an optimum schedule for replacing components on or before the end of a fixed replacement period. Although written to analyze the electrical power system on the Space Station Freedom, RSM is quite general and can be used to model the resupply of almost any system subject to user-defined resource constraints. RSM is based on a specific form of the general linear programming problem in which all variables in the objective function and all variables in the constraints are integers. While more computationally intensive, integer programming was required for accuracy when modeling systems with small quantities of components. Input values for component life cane be real numbers, RSM converts them to integers by dividing the lifetime by the period duration, then reducing the result to the next lowest integer. For each component, there is a set of constraints that insure that it is replaced before its lifetime expires. RSM includes user-defined constraints such as transportation mass and volume limits, as well as component life, available repair crew time and assembly sequences. A weighting factor allows the program to minimize factors such as cost. The program then performs an iterative analysis, which is displayed during the processing. A message gives the first period in which resources are being exceeded on each iteration. If the scheduling problem is unfeasible, the final message will also indicate the first period in which resources were exceeded. RSM is written in APL2 for IBM PC series computers and compatibles. A stand-alone executable version of RSM is provided; however, this is a "packed" version of RSM which can only utilize the memory within the 640K DOS limit. This executable requires at least 640K of memory and DOS 3.1 or higher. Source code for an APL2/PC workspace version is also provided. This version of RSM can make full use of any

Selecting Tools to Model Integer and Binomial Multiplication

Science.gov (United States)

Pratt, Sarah Smitherman; Eddy, Colleen M.

2017-01-01

Mathematics teachers frequently provide concrete manipulatives to students during instruction; however, the rationale for using certain manipulatives in conjunction with concepts may not be explored. This article focuses on area models that are currently used in classrooms to provide concrete examples of integer and binomial multiplication. The…

Core barrier formation near integer q surfaces in DIII-D

International Nuclear Information System (INIS)

Austin, M. E.; Gentle, K. W.; Burrell, K. H.; Waltz, R. E.; Gohil, P.; Greenfield, C. M.; Groebner, R. J.; Petty, C. C.; Prater, R.; Heidbrink, W. W.; Luo, Y.; Kinsey, J. E.; Makowski, M. A.; McKee, G. R.; Shafer, M. W.; Nazikian, R.; Rhodes, T. L.; Van Zeeland, M. A.

2006-01-01

Recent DIII-D experiments have significantly improved the understanding of internal transport barriers (ITBs) that are triggered close to the time when an integer value of the minimum in q is crossed. While this phenomenon has been observed on many tokamaks, the extensive transport and fluctuation diagnostics on DIII-D have permitted a detailed study of the generation mechanisms of q-triggered ITBs as pertaining to turbulence suppression dynamics, shear flows, and energetic particle modes. In these discharges, the evolution of the q profile is measured using motional Stark effect polarimetry and the integer q min crossings are further pinpointed in time by the observation of Alfven cascades. High time resolution measurements of the ion and electron temperatures and the toroidal rotation show that the start of improved confinement is simultaneous in all three channels, and that this event precedes the traversal of integer q min by 5-20 ms. There is no significant low-frequency magnetohydrodynamic activity prior to or just after the crossing of the integer q min and hence magnetic reconnection is determined not to be the precipitant of the confinement change. Instead, results from the GYRO code point to the effects of zonal flows near low order rational q values as playing a role in ITB triggering. A reduction in local turbulent fluctuations is observed at the start of the temperature rise and, concurrently, an increase in turbulence poloidal flow velocity and flow shear is measured with the beam emission spectroscopy diagnostic. For the case of a transition to an enduring internal barrier the fluctuation level remains at a reduced amplitude. The timing and nature of the temperature, rotation, and fluctuation changes leading to internal barriers suggests transport improvement due to increased shear flow arising from the zonal flow structures

Average Estimates of Water-Budget Components Based on Hydrograph Separation and PRISM Precipitation for Gaged Basins in the Appalachian Plateaus Region, 1900-2011

Data.gov (United States)

Department of the Interior — As part of the U.S. Geological Survey’s Groundwater Resources Program study of the Appalachian Plateaus aquifers, estimates of annual water-budget components were...

Annual Estimates of Water-Budget Components Based on Hydrograph Separation and PRISM Precipitation for Gaged Basins in the Appalachian Plateaus Region, 1900-2011

Data.gov (United States)

Department of the Interior — As part of the U.S. Geological Survey’s Groundwater Resources Program study of the Appalachian Plateaus aquifers, estimates of annual water-budget components were...

A new VLSI complex integer multiplier which uses a quadratic-polynomial residue system with Fermat numbers

Science.gov (United States)

Shyu, H. C.; Reed, I. S.; Truong, T. K.; Hsu, I. S.; Chang, J. J.

1987-01-01

A quadratic-polynomial Fermat residue number system (QFNS) has been used to compute complex integer multiplications. The advantage of such a QFNS is that a complex integer multiplication requires only two integer multiplications. In this article, a new type Fermat number multiplier is developed which eliminates the initialization condition of the previous method. It is shown that the new complex multiplier can be implemented on a single VLSI chip. Such a chip is designed and fabricated in CMOS-Pw technology.

Travelling plateaus for a hyperbolic Keller–Segel system with attraction and repulsion: existence and branching instabilities

International Nuclear Information System (INIS)

Perthame, Benoît; Tang, Min; Vauchelet, Nicolas; Schmeiser, Christian

2011-01-01

How can repulsive and attractive forces, acting on a conservative system, create stable travelling patterns or branching instabilities? We have proposed to study this question in the framework of the hyperbolic Keller–Segel system with logistic sensitivity. This is a model system motivated by experiments on cell communities auto-organization, a field which is also called socio-biology. We continue earlier modelling work, where we have shown numerically that branching patterns arise for this system and we have analysed this instability by formal asymptotics for small diffusivity of the chemo-repellent. Here we are interested in the more general situation, where the diffusivities of both the chemo-attractant and the chemo-repellent are positive. To do so, we develop an appropriate functional analysis framework. We apply our method to two cases. Firstly we analyse steady states. Secondly we analyse travelling waves when neglecting the degradation coefficient of the chemo-repellent; the unique wave speed appears through a singularity cancellation which is the main theoretical difficulty. This shows that in different situations the cell density takes the shape of a plateau. The existence of steady states and travelling plateaus are a symptom of how rich the system is and why branching instabilities can occur. Numerical tests show that large plateaus may split into smaller ones, which remain stable

Lymphoproliferative disorders in non-AIDS associated Kaposi's ...

African Journals Online (AJOL)

The association of the non-AIDS-related, classic fonn of Kaposi's sarcoma (KS) with secondary malignancies, especially Iymphoproliferative disorders, has frequently been noted. However, in endemic: African-type KS, such an association has been reported only rarely. A review of 62 non-AIDS-related cases of KS treated ...

Pinning mode of integer quantum Hall Wigner crystal of skyrmions

Science.gov (United States)

Zhu, Han; Sambandamurthy, G.; Chen, Y. P.; Jiang, P.-H.; Engel, L. W.; Tsui, D. C.; Pfeiffer, L. N.; West, K. W.

2009-03-01

Just away from integer Landau level (LL) filling factors ν, the dilute quasi-particles/holes at the partially filled LL form an integer-quantum-Hall Wigner crystal, which exhibits microwave pinning mode resonances [1]. Due to electron-electron interaction, it was predicted that the elementary excitation around ν= 1 is not a single spin flip, but a larger-scale spin texture, known as a skyrmion [2]. We have compared the pinning mode resonances [1] of integer quantum Hall Wigner crystals formed in the partly filled LL just away from ν= 1 and ν= 2, in the presence of an in-plane magnetic field. As an in-plane field is applied, the peak frequencies of the resonances near ν= 1 increase, while the peak frequencies below ν= 2 show neligible dependence on in-plane field. We interpret this observation as due to a skyrmion crystal phase around ν= 1 and a single-hole Wigner crystal phase below ν= 2. The in-plane field increases the Zeeman gap and causes shrinking of the skyrmion size toward single spin flips. [1] Yong P. Chen et al., Phys. Rev. Lett. 91, 016801 (2003). [2] S. L. Sondhi et al., Phys. Rev. B 47, 16 419 (1993); L. Brey et al., Phys. Rev. Lett. 75, 2562 (1995).

Note on Integer-Valued Bilinear Time Series Models

NARCIS (Netherlands)

Drost, F.C.; van den Akker, R.; Werker, B.J.M.

2007-01-01

Summary. This note reconsiders the nonnegative integer-valued bilinear processes introduced by Doukhan, Latour, and Oraichi (2006). Using a hidden Markov argument, we extend their result of the existence of a stationary solution for the INBL(1,0,1,1) process to the class of superdiagonal INBL(p; q;

Computer Corner: Spreadsheets, Power Series, Generating Functions, and Integers.

Science.gov (United States)

Snow, Donald R.

1989-01-01

Implements a table algorithm on a spreadsheet program and obtains functions for several number sequences such as the Fibonacci and Catalan numbers. Considers other applications of the table algorithm to integers represented in various number bases. (YP)

Fast parallel DNA-based algorithms for molecular computation: quadratic congruence and factoring integers.

Science.gov (United States)

Chang, Weng-Long

2012-03-01

Assume that n is a positive integer. If there is an integer such that M (2) ≡ C (mod n), i.e., the congruence has a solution, then C is said to be a quadratic congruence (mod n). If the congruence does not have a solution, then C is said to be a quadratic noncongruence (mod n). The task of solving the problem is central to many important applications, the most obvious being cryptography. In this article, we describe a DNA-based algorithm for solving quadratic congruence and factoring integers. In additional to this novel contribution, we also show the utility of our encoding scheme, and of the algorithm's submodules. We demonstrate how a variety of arithmetic, shifted and comparative operations, namely bitwise and full addition, subtraction, left shifter and comparison perhaps are performed using strands of DNA.

An integer ambiguity resolution method for the global positioning system (GPS)-based land vehicle attitude determination

International Nuclear Information System (INIS)

Wang, Bo; Miao, Lingjuan; Wang, Shunting; Shen, Jun

2009-01-01

During attitude determination using a global positioning system (GPS), cycle slips occur due to the loss of lock and noise disturbance. Therefore, the integer ambiguity needs re-computation to isolate the error in carrier phase. This paper presents a fast method for integer ambiguity resolution for land vehicle application. After the cycle slips are detected, the velocity vector is utilized to obtain the rough baseline vector. The obtained baseline vector is substituted into carrier phase observation equations to solve the float ambiguity solution which can be used as a constraint to accelerate the integer ambiguity search procedure at next epochs. The probability of correct integer estimation in the expanded search space is analyzed. Experimental results demonstrate that the proposed method gives a fast approach to obtain new fixed ambiguities while the regular method takes longer time and sometimes results in incorrect solutions

Spatial “Artistic” Networks: From Deconstructing Integer-Functions to Visual Arts

Directory of Open Access Journals (Sweden)

Ernesto Estrada

2018-01-01

Full Text Available Deconstructivism is an aesthetically appealing architectonic style. Here, we identify some general characteristics of this style, such as decomposition of the whole into parts, superposition of layers, and conservation of the memory of the whole. Using these attributes, we propose a method to deconstruct functions based on integers. Using this integer-function deconstruction we generate spatial networks which display a few artistic attributes such as (i biomorphic shapes, (ii symmetry, and (iii beauty. In building these networks, the deconstructed integer-functions are used as the coordinates of the nodes in a unit square, which are then joined according to a given connection radius like in random geometric graphs (RGGs. Some graph-theoretic invariants of these networks are calculated and compared with the classical RGGs. We then show how these networks inspire an artist to create artistic compositions using mixed techniques on canvas and on paper. Finally, we call for avoiding that the applicability of (network sciences should not go in detriment of curiosity-driven, and aesthetic-driven, researches. We claim that the aesthetic of network research, and not only its applicability, would be an attractor for new minds to this field.

FATCOP: A Fault Tolerant Condor-PVM Mixed Integer Program Solver

National Research Council Canada - National Science Library

Chen, Qun

1999-01-01

We describe FATCOP, a new parallel mixed integer program solver written in PVM. The implementation uses the Condor resource management system to provide a virtual machine composed of otherwise idle computers...

[Negative symptoms in patients with non schizophrenic psychiatric disorders].

Science.gov (United States)

Donnoli, Vicente F; Moroni, María V; Cohen, Diego; Chisari Rocha, Liliana; Marleta, María; Sepich Dalmeida, Tomás; Bonani, Matías; D'Alessio, Luciana

2011-01-01

The presence of negative symptoms (NS) in different clinical entities other than schizophrenia, with a dimensional approach of negative symptoms, was considered in this work. Determine the presence and distribution of NS, in a population of patients with non schizophrenic psychiatric disorders attending ambulatory treatment at public hospitals. Patients with define DSM IV diagnosis criteria for different disorders; affective, alimentary, substance abuse, anxiety, personality disorders and patients with ILAE diagnoses criteria for temporal lobe epilepsy were included. All patients underwent the subscale PANNS for negative symptoms of schizophrenia. Student T test was calculated to determine the differences of frequency for NS among psychiatric disorders. 106 patients were included; 60 women, 46 men, 38 years +/- 12.1. The 90% of patients have a low score of NS. Media 11.6, Max/min 9.38 -14.29. Emotional withdrawal and passive social withdrawal were more frequent in alimentary disorders than in affective disorder and than in epilepsy. Emotional withdrawal was more frequent in substance disorders than epilepsy. According this study, negative symptoms are present in a low to moderate intensity in non schizophrenic psychiatry entities and in the temporal lobe epilepsy.

A Branch and Bound Algorithm for a Class of Biobjective Mixed Integer Programs

DEFF Research Database (Denmark)

Stidsen, Thomas Riis; Andersen, Kim Allan; Dammann, Bernd

2014-01-01

there is the complicating factor that some of the variables are required to be integral. The resulting class of problems is named multiobjective mixed integer programming (MOMIP) problems. Solving these kinds of optimization problems exactly requires a method that can generate the whole set of nondominated points (the...... Pareto-optimal front). In this paper, we first give a survey of the newly developed branch and bound methods for solving MOMIP problems. After that, we propose a new branch and bound method for solving a subclass of MOMIP problems, where only two objectives are allowed, the integer variables are binary......, and one of the two objectives has only integer variables. The proposed method is able to find the full set of nondominated points. It is tested on a large number of problem instances, from six different classes of MOMIP problems. The results reveal that the developed biobjective branch and bound method...

A wavelet-based ECG delineation algorithm for 32-bit integer online processing.

Science.gov (United States)

Di Marco, Luigi Y; Chiari, Lorenzo

2011-04-03

Since the first well-known electrocardiogram (ECG) delineator based on Wavelet Transform (WT) presented by Li et al. in 1995, a significant research effort has been devoted to the exploitation of this promising method. Its ability to reliably delineate the major waveform components (mono- or bi-phasic P wave, QRS, and mono- or bi-phasic T wave) would make it a suitable candidate for efficient online processing of ambulatory ECG signals. Unfortunately, previous implementations of this method adopt non-linear operators such as root mean square (RMS) or floating point algebra, which are computationally demanding. This paper presents a 32-bit integer, linear algebra advanced approach to online QRS detection and P-QRS-T waves delineation of a single lead ECG signal, based on WT. The QRS detector performance was validated on the MIT-BIH Arrhythmia Database (sensitivity Se = 99.77%, positive predictive value P+ = 99.86%, on 109010 annotated beats) and on the European ST-T Database (Se = 99.81%, P+ = 99.56%, on 788050 annotated beats). The ECG delineator was validated on the QT Database, showing a mean error between manual and automatic annotation below 1.5 samples for all fiducial points: P-onset, P-peak, P-offset, QRS-onset, QRS-offset, T-peak, T-offset, and a mean standard deviation comparable to other established methods. The proposed algorithm exhibits reliable QRS detection as well as accurate ECG delineation, in spite of a simple structure built on integer linear algebra.

Consciousness in Non-Epileptic Attack Disorder

OpenAIRE

Reuber, M.; Kurthen, M.

2011-01-01

Non-epileptic attack disorder (NEAD) is one of the most important differential diagnoses of epilepsy. Impairment of\\ud consciousness is the key feature of non-epileptic attacks (NEAs). The first half of this review summarises the clinical research\\ud literature featuring observations relating to consciousness in NEAD. The second half places this evidence in the wider context\\ud of the recent discourse on consciousness in neuroscience and the philosophy of mind. We argue that studies of consci...

Fractional and integer charges from Levinson's theorem

International Nuclear Information System (INIS)

Farhi, E.; Graham, N.; Jaffe, R.L.; Weigel, H.

2001-01-01

We compute fractional and integer fermion quantum numbers of static background field configurations using phase shifts and Levinson's theorem. By extending fermionic scattering theory to arbitrary dimensions, we implement dimensional regularization in a (1+1)-dimensional gauge theory. We demonstrate that this regularization procedure automatically eliminates the anomaly in the vector current that a naive regulator would produce. We also apply these techniques to bag models in one and three dimensions

Solving stochastic programs with integer recourse by enumeration : a framework using Gröbner basis reductions

NARCIS (Netherlands)

Schultz, R.; Stougie, L.; Vlerk, van der M.H.

1998-01-01

In this paper we present a framework for solving stochastic programs with complete integer recourse and discretely distributed right-hand side vector, using Gröbner basis methods from computational algebra to solve the numerous second-stage integer programs. Using structural properties of the

Tectonic evolution of the Caribbean and northwestern South America: The case for accretion of two Late Cretaceous oceanic plateaus

Science.gov (United States)

Kerr, Andrew C.; Tarney, John

2005-04-01

It is widely accepted that the thickened oceanic crust of the Caribbean plate, its basaltic accreted margins, and accreted mafic terranes in northwestern South America represent the remnants of a single ca. 90 Ma oceanic plateau. We review geologic, geochemical, and paleomagnetic evidence that suggests that the Caribbean-Colombian oceanic plateau in fact represents the remnants of two different oceanic plateaus, both dated as ca. 90 Ma. The first of these plateaus, the Caribbean Plateau, formed ca. 90 Ma in the vicinity of the present-day Galapagos hotspot. Northeastward movement of the Farallon plate meant that this plateau collided with the proto Caribbean arc and northwestern South America Gorgona Plateau, formed at 26° 30°S, possibly at the site of the present-day Sala y Gomez hotspot. Over the next ˜45 m.y., this plateau was carried progressively northeastward on the Farallon plate and collided in the middle Eocene with the proto Andean subduction zone in northwestern South America. The recognition of a second ca. 90 Ma Pacific oceanic plateau strengthens the link between plateau formation and global oceanic anoxic events.

Designing fractional factorial split-plot experiments using integer programming

DEFF Research Database (Denmark)

Capehart, Shay R.; Keha, Ahmet; Kulahci, Murat

2011-01-01

factorial (FF) design, with the restricted randomisation structure to account for the whole plots and subplots. We discuss the formulation of FFSP designs using integer programming (IP) to achieve various design criteria. We specifically look at the maximum number of clear two-factor interactions...

Quantum recurrence and integer ratios in neutron resonances

Energy Technology Data Exchange (ETDEWEB)

Ohkubo, Makio

1998-03-01

Quantum recurrence of the compound nucleus in neutron resonance reactions are described for normal modes which are excited on the compound nucleus simultaneously. In the structure of the recurrence time, integer relations among dominant level spacings are derived. The `base modes` are assumed as stable combinations of the normal modes, preferably excited in many nuclei. (author)

Integer Flows and Circuit Covers of Graphs and Signed Graphs

Science.gov (United States)

Cheng, Jian

The work in Chapter 2 is motivated by Tutte and Jaeger's pioneering work on converting modulo flows into integer-valued flows for ordinary graphs. For a signed graphs (G, sigma), we first prove that for each k ∈ {2, 3}, if (G, sigma) is (k - 1)-edge-connected and contains an even number of negative edges when k = 2, then every modulo k-flow of (G, sigma) can be converted into an integer-valued ( k + 1)-ow with a larger or the same support. We also prove that if (G, sigma) is odd-(2p+1)-edge-connected, then (G, sigma) admits a modulo circular (2 + 1/ p)-flows if and only if it admits an integer-valued circular (2 + 1/p)-flows, which improves all previous result by Xu and Zhang (DM2005), Schubert and Steffen (EJC2015), and Zhu (JCTB2015). Shortest circuit cover conjecture is one of the major open problems in graph theory. It states that every bridgeless graph G contains a set of circuits F such that each edge is contained in at least one member of F and the length of F is at most 7/5∥E(G)∥. This concept was recently generalized to signed graphs by Macajova et al. (JGT2015). In Chapter 3, we improve their upper bound from 11∥E( G)∥ to 14/3 ∥E(G)∥, and if G is 2-edgeconnected and has even negativeness, then it can be further reduced to 11/3 ∥E(G)∥. Tutte's 3-flow conjecture has been studied by many graph theorists in the last several decades. As a new approach to this conjecture, DeVos and Thomassen considered the vectors as ow values and found that there is a close relation between vector S1-flows and integer 3-NZFs. Motivated by their observation, in Chapter 4, we prove that if a graph G admits a vector S1-flow with rank at most two, then G admits an integer 3-NZF. The concept of even factors is highly related to the famous Four Color Theorem. We conclude this dissertation in Chapter 5 with an improvement of a recent result by Chen and Fan (JCTB2016) on the upperbound of even factors. We show that if a graph G contains an even factor, then it

Effects of sleep disorders on the non-motor symptoms of Parkinson disease.

Science.gov (United States)

Neikrug, Ariel B; Maglione, Jeanne E; Liu, Lianqi; Natarajan, Loki; Avanzino, Julie A; Corey-Bloom, Jody; Palmer, Barton W; Loredo, Jose S; Ancoli-Israel, Sonia

2013-11-15

To evaluate the impact of sleep disorders on non-motor symptoms in patients with Parkinson disease (PD). This was a cross-sectional study. Patients with PD were evaluated for obstructive sleep apnea (OSA), restless legs syndrome (RLS), periodic limb movement syndrome (PLMS), and REM sleep behavior disorder (RBD). Cognition was assessed with the Montreal Cognitive Assessment and patients completed self-reported questionnaires assessing non-motor symptoms including depressive symptoms, fatigue, sleep complaints, daytime sleepiness, and quality of life. Sleep laboratory. 86 patients with PD (mean age = 67.4 ± 8.8 years; range: 47-89; 29 women). N/A. Having sleep disorders was a predictor of overall non-motor symptoms in PD (R(2) = 0.33, p sleep disorder significantly predicted sleep complaints (ΔR(2) = 0.13, p = 0.006), depressive symptoms (ΔR(2) = 0.01, p = 0.03), fatigue (ΔR(2) = 0.12, p = 0.007), poor quality of life (ΔR(2) = 0.13, p = 0.002), and cognitive decline (ΔR(2) = 0.09, p = 0.036). Additionally, increasing number of sleep disorders (0, 1, or ≥ 2 sleep disorders) was a significant contributor to non-motor symptom impairment (R(2) = 0.28, p sleep disorders predicted more non-motor symptoms including increased sleep complaints, more depressive symptoms, lower quality of life, poorer cognition, and more fatigue. RBD and RLS were factors of overall increased non-motor symptoms, but OSA was not.

Integers without Large Prime Factors in Short Intervals: Conditional ...

Indian Academy of Sciences (India)

... Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Proceedings – Mathematical Sciences; Volume 120; Issue 5. Integers without Large Prime Factors in Short Intervals: Conditional Results. Goutam Pal Satadal Ganguly. Volume 120 Issue 5 November 2010 pp 515-524 ...

Lymphoproliferative disorders in non-AIDS- associated Kaposi's ...

African Journals Online (AJOL)

proliferative disorders are mostly of B-cell origin and include non-Hodgkin's lymphoma, chronic lymphatic leukaemia and multiple .... Bone marrow trephine biopsy revealed ... transplants, patients with auto-immune diseases and patients with ...

Integer Set Compression and Statistical Modeling

DEFF Research Database (Denmark)

Larsson, N. Jesper

2014-01-01

enumeration of elements may be arbitrary or random, but where statistics is kept in order to estimate probabilities of elements. We present a recursive subset-size encoding method that is able to benefit from statistics, explore the effects of permuting the enumeration order based on element probabilities......Compression of integer sets and sequences has been extensively studied for settings where elements follow a uniform probability distribution. In addition, methods exist that exploit clustering of elements in order to achieve higher compression performance. In this work, we address the case where...

On the price of integer charge quarks

International Nuclear Information System (INIS)

Okun, L.B.; Voloshin, M.B.; Zakharov, V.I.

1979-01-01

Implication of the integer charge quark (ICQ) model with a broken SU(3)xU(1) gauge symmetry for interactions in the leptonic sector were discussed. In this model there should be very large deviations of e + e - →μ + μ - annihilation processes in the GeV region from the standard QED behaviour. Such deviations seem to be completely excluded by existing data. Therefore it is concluded that the ICQ model is ruled out

BitPAl: a bit-parallel, general integer-scoring sequence alignment algorithm.

Science.gov (United States)

Loving, Joshua; Hernandez, Yozen; Benson, Gary

2014-11-15

Mapping of high-throughput sequencing data and other bulk sequence comparison applications have motivated a search for high-efficiency sequence alignment algorithms. The bit-parallel approach represents individual cells in an alignment scoring matrix as bits in computer words and emulates the calculation of scores by a series of logic operations composed of AND, OR, XOR, complement, shift and addition. Bit-parallelism has been successfully applied to the longest common subsequence (LCS) and edit-distance problems, producing fast algorithms in practice. We have developed BitPAl, a bit-parallel algorithm for general, integer-scoring global alignment. Integer-scoring schemes assign integer weights for match, mismatch and insertion/deletion. The BitPAl method uses structural properties in the relationship between adjacent scores in the scoring matrix to construct classes of efficient algorithms, each designed for a particular set of weights. In timed tests, we show that BitPAl runs 7-25 times faster than a standard iterative algorithm. Source code is freely available for download at http://lobstah.bu.edu/BitPAl/BitPAl.html. BitPAl is implemented in C and runs on all major operating systems. jloving@bu.edu or yhernand@bu.edu or gbenson@bu.edu Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

Right Propositional Neighborhood Logic over Natural Numbers with Integer Constraints for Interval Lengths

DEFF Research Database (Denmark)

Bresolin, Davide; Goranko, Valentin; Montanari, Angelo

2009-01-01

Interval temporal logics are based on interval structures over linearly (or partially) ordered domains, where time intervals, rather than time instants, are the primitive ontological entities. In this paper we introduce and study Right Propositional Neighborhood Logic over natural numbers...... with integer constraints for interval lengths, which is a propositional interval temporal logic featuring a modality for the 'right neighborhood' relation between intervals and explicit integer constraints for interval lengths. We prove that it has the bounded model property with respect to ultimately periodic...

Peaks, plateaus, canyons, and craters: The complex geometry of simple mid-domain effect models

DEFF Research Database (Denmark)

Colwell, Robert K.; Gotelli, Nicholas J.; Rahbek, Carsten

2009-01-01

dye algorithm to place assemblages of species of uniform We used a spreading dye algorithm to place assemblages of species of uniform range size in one-dimensional or two-dimensional bounded domains. In some models, we allowed dispersal to introduce range discontinuity. Results: As uniform range size...... increases from small to medium, a flat pattern of species As uniform range size increases from small to medium, a flat pattern of species richness is replaced by a pair of peripheral peaks, separated by a valley (one-dimensional models), or by a cratered ring (two-dimensional models) of species richness...... of a uniform size generate more complex patterns, including peaks, plateaus, canyons, and craters of species richness....

New Approaches for Very Large-Scale Integer Programming

Science.gov (United States)

2016-06-24

DISTRIBUTION/ AVAILABILITY STATEMENT Approved for Public Release 13. SUPPLEMENTARY NOTES 14. ABSTRACT The focus of this project is new computational... heuristics for integer programs in order to rapidly improve dual bounds. 2. Choosing good branching variables in branch-and-bound algorithms for MIP. 3...programming, algorithms, parallel processing, machine learning, heuristics 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF

What Else Is Decidable about Integer Arrays?

OpenAIRE

Habermehl, Peter; Iosif, Radu; Vojnar, Tomáš

2008-01-01

International audience; We introduce a new decidable logic for reasoning about infinite arrays of integers. The logic is in the ∃ * ∀ * first-order fragment and allows (1) Presburger constraints on existentially quantified variables, (2) difference constraints as well as periodicity constraints on universally quantified indices, and (3) difference constraints on values. In particular, using our logic, one can express constraints on consecutive elements of arrays (e.g. ∀i. 0 ≤ i < n → a[i + 1]...

Integer programming for the generalized high school timetabling problem

DEFF Research Database (Denmark)

Kristiansen, Simon; Sørensen, Matias; Stidsen, Thomas Riis

2015-01-01

, the XHSTT format serves as a common ground for researchers within this area. This paper describes the first exact method capable of handling an arbitrary instance of the XHSTT format. The method is based on a mixed-integer linear programming (MIP) model, which is solved in two steps with a commercial...

Non-human Primate Models for Brain Disorders - Towards Genetic Manipulations via Innovative Technology.

Science.gov (United States)

Qiu, Zilong; Li, Xiao

2017-04-01

Modeling brain disorders has always been one of the key tasks in neurobiological studies. A wide range of organisms including worms, fruit flies, zebrafish, and rodents have been used for modeling brain disorders. However, whether complicated neurological and psychiatric symptoms can be faithfully mimicked in animals is still debatable. In this review, we discuss key findings using non-human primates to address the neural mechanisms underlying stress and anxiety behaviors, as well as technical advances for establishing genetically-engineered non-human primate models of autism spectrum disorders and other disorders. Considering the close evolutionary connections and similarity of brain structures between non-human primates and humans, together with the rapid progress in genome-editing technology, non-human primates will be indispensable for pathophysiological studies and exploring potential therapeutic methods for treating brain disorders.

Untended Wounds: Non-Suicidal Self-Injury in Adults with Autism Spectrum Disorder

Science.gov (United States)

Maddox, Brenna B.; Trubanova, Andrea; White, Susan W.

2017-01-01

Recent studies have examined non-suicidal self-injury in community and clinical samples, but there is no published research on non-suicidal self-injury in individuals with autism spectrum disorder. This lack of research is surprising, since individuals with autism spectrum disorder have high rates of risk factors for non-suicidal self-injury,…

Enteroclysis of non-neoplastic disorders of the small intestine

International Nuclear Information System (INIS)

Nolan, D.J.

2000-01-01

Enteroclysis is now widely used for examining the jejunum and ileum. The technique is ideal for demonstrating the extent and severity of disorders that cause morphological changes to the small intestine. In this review many non-neoplastic small intestinal disorders as demonstrated by enteroclysis are described and illustrated. (orig.)

Economic burden of non-malignant blood disorders across Europe: a population-based cost study.

Science.gov (United States)

Luengo-Fernandez, Ramon; Burns, Richeal; Leal, Jose

2016-08-01

Blood disorders comprise a wide range of diseases including anaemia, malignant blood disorders, and haemorrhagic disorders. Although they are a common cause of disease, no systematic cost-of-illness studies have been done to assess the economic effect of non-malignant blood disorders in Europe. We aimed to assess the economic burden of non-malignant blood disorders across the 28 countries of the European Union (EU), Iceland, Norway, and Switzerland. Non-malignant blood disorder-related costs (WHO International Classification of Diseases, 10th revision [ICD] D50-89) were estimated for 28 EU countries, Iceland, Norway, and Switzerland for 2012. Country-specific costs were estimated with aggregate data on morbidity, mortality, and health-care resource use obtained from international and national sources. Health-care costs were estimated from expenditure on primary care, outpatient care, emergency care, hospital inpatient care, and drugs. Costs of informal care and productivity losses due to morbidity and early death were also included. To these costs we added those due to malignant blood disorders (ICD-10 C81-96 and D47) as estimated in a Burns and colleagues' companion Article to obtain the total costs of blood disorders. Non-malignant disorders of the blood cost the 31 European countries €11 billion in 2012. Health-care costs accounted for €8 billion (75% of total costs), productivity losses for €2 billion (19%), and informal care for less than €1 billion (6%). Averaged across the European population studied, non-malignant disorders of the blood represented an annual health-care cost of €159 per ten citizens. Combining malignant and non-malignant blood disorders, the total cost of blood disorders was €23 billion in 2012. Our study highlights the economic burden that non-malignant blood disorders place on European health-care systems and societies. Our study also shows that blood disorder costs were evenly distributed between malignant and non

Is there a computable upper bound for the height of a solution of a Diophantine equation with a unique solution in positive integers?

Directory of Open Access Journals (Sweden)

Tyszka Apoloniusz

2017-03-01

Full Text Available Let Bn = {xi · xj = xk : i, j, k ∈ {1, . . . , n}} ∪ {xi + 1 = xk : i, k ∈ {1, . . . , n}} denote the system of equations in the variables x1, . . . , xn. For a positive integer n, let _(n denote the smallest positive integer b such that for each system of equations S ⊆ Bn with a unique solution in positive integers x1, . . . , xn, this solution belongs to [1, b]n. Let g(1 = 1, and let g(n + 1 = 22g(n for every positive integer n. We conjecture that ξ (n 6 g(2n for every positive integer n. We prove: (1 the function ξ : N \\ {0} → N \\ {0} is computable in the limit; (2 if a function f : N \\ {0} → N \\ {0} has a single-fold Diophantine representation, then there exists a positive integer m such that f (n m; (3 the conjecture implies that there exists an algorithm which takes as input a Diophantine equation D(x1, . . . , xp = 0 and returns a positive integer d with the following property: for every positive integers a1, . . . , ap, if the tuple (a1, . . . , ap solely solves the equation D(x1, . . . , xp = 0 in positive integers, then a1, . . . , ap 6 d; (4 the conjecture implies that if a set M ⊆ N has a single-fold Diophantine representation, then M is computable; (5 for every integer n > 9, the inequality ξ (n < (22n−5 − 12n−5 + 1 implies that 22n−5 + 1 is composite.

A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION: Rationale and design

Directory of Open Access Journals (Sweden)

Clarke Simon D

2011-03-01

Full Text Available Abstract Background The ACTION study (Attention deficit hyperactivity disorder Controlled Trial Investigation Of a Non-stimulant is a multi-center, double-blind, randomized cross-over trial of the non-stimulant medication, Atomoxetine, in children and adolescents with attention deficit hyperactivity disorder (ADHD. The primary aims are to examine the efficacy of atomoxetine for improving cognition and emotional function in ADHD and whether any improvements in these outcomes are more pronounced in participants with comorbid anxiety; and to determine if changes in these outcomes after atomoxetine are more reliable than changes in diagnostic symptoms of ADHD. This manuscript will describe the methodology and rationale for the ACTION study. Methods Children and adolescents aged 6 - 17 y with ADHD will be enrolled. Clinical interview and validated scales will be used to confirm diagnosis and screen for exclusion criteria, which include concurrent stimulant use, and comorbid psychiatric or neurological conditions other than anxiety. Three assessment sessions will be conducted over the 13-week study period: Session 1 (Baseline, pre-treatment, Session 2 (six weeks, atomoxetine or placebo, and Session 3 (13 weeks, cross-over after one-week washout period. The standardized touch-screen battery, "IntegNeuro™", will be used to assess cognitive and emotional function. The primary measure of response will be symptom ratings, while quality of life will be a secondary outcome. Logistic regression will be used to determine predictors of treatment response, while repeated measures of analysis will determine any differences in effect of atomoxetine and placebo. Results The methodology for the ACTION study has been detailed. Conclusions The ACTION study is the first controlled trial to investigate the efficacy of atomoxetine using objective cognitive and emotional function markers, and whether these objective measures predict outcomes with atomoxetine in ADHD

Non medical factors associated with psychological disorders in cancer patients

International Nuclear Information System (INIS)

Iqbal, A.; Intikhab, K.; Saeed, K.

2002-01-01

Objective: To find out major non-medial factors associated with psychological disorders in cancer patients. Design: An observational study conducted on adult cancer patients. Place and Duration of Study: The study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Center Lahore Pakistan from January 1999. Patients and Methods: Two hundred and twenty-four newly-diagnosed adult cancer patients were interviewed by the clinical psychologist and data was collected regarding non-medical causal factors, patients age, gender family support system, general home atmosphere and marital status. Collected data was analyzed by utilizing. SPSS for windows version 10.0. Results: Of the 224 patients 142 (63.4%) reported non-medical factors causing psychological distress and 82 (36.6%) reported that medical sources are the most distressing. Ten most common non-medical sources of developing psychological disorders were identified. It was observed that family support system and general home atmosphere were significantly associated with the development of psychological disorders whereas the other variables such as age, gender and marital status had no significant relationship with the non Medical factors. Conclusion: It was concluded that non-medical factors causing psychological problems are significant in cancer patients. The results suggest that we should identify these factors and target psychosocial intervention for those patients most at risk. (author)

Direct comparison of fractional and integer quantized Hall resistance

Science.gov (United States)

Ahlers, Franz J.; Götz, Martin; Pierz, Klaus

2017-08-01

We present precision measurements of the fractional quantized Hall effect, where the quantized resistance {{R}≤ft[ 1/3 \\right]} in the fractional quantum Hall state at filling factor 1/3 was compared with a quantized resistance {{R}[2]} , represented by an integer quantum Hall state at filling factor 2. A cryogenic current comparator bridge capable of currents down to the nanoampere range was used to directly compare two resistance values of two GaAs-based devices located in two cryostats. A value of 1-(5.3  ±  6.3) 10-8 (95% confidence level) was obtained for the ratio ({{R}≤ft[ 1/3 \\right]}/6{{R}[2]} ). This constitutes the most precise comparison of integer resistance quantization (in terms of h/e 2) in single-particle systems and of fractional quantization in fractionally charged quasi-particle systems. While not relevant for practical metrology, such a test of the validity of the underlying physics is of significance in the context of the upcoming revision of the SI.

Rigorous solution to Bargmann-Wigner equation for integer spin

CERN Document Server

Huang Shi Zhong; Wu Ning; Zheng Zhi Peng

2002-01-01

A rigorous method is developed to solve the Bargamann-Wigner equation for arbitrary integer spin in coordinate representation in a step by step way. The Bargmann-Wigner equation is first transformed to a form easier to solve, the new equations are then solved rigorously in coordinate representation, and the wave functions in a closed form are thus derived

Comparing attentional control and intrusive thoughts in obsessive-compulsive disorder, generalized anxiety disorder and non clinical population.

Directory of Open Access Journals (Sweden)

Mehri Moradi

2014-06-01

Full Text Available Attention is an important factor in information processing; obsessive- compulsive disorder (OCD and generalized anxiety disorder (GAD are two main emotional disorders with a chronic course. This research examined the relationship among attentional control and intrusive thoughts (worry, rumination and obsession in these disorders. It was hypothesized that attentional control is a common factor in OCD and GAD. In addition, we compared worry, rumination and obsession among OCD, GAD and non- clinical participants.The research sample included three groups: OCD (n = 25, GAD (n = 30 and non- clinical samples (n = 56. Data were collected using the Attentional Control Scale (ACS, Rumination Response Scale (RRS, Pennsylvania State Worry Questionnaire (PSWQ, Beck Depression Inventory (BDI, Beck Anxiety Inventory (BAI, Obsessive-Compulsive Inventory-Revised (OCI-R and General Health Questionnaire (GHQ-28. Data were analyzed using MANOVA and MANCOVA by SPSS-17.Multivariate Analysis of Variance revealed that the OCD and GAD groups reported greater deficits in attentional control, higher obsessive-compulsive symptoms, rumination, worry, anxiety and depression compared to the control group.This research indicated a great attentional deficit in obsessive- compulsive disorder and generalized anxiety disorder. However, no significant difference was found between these two disorders.

Non-verbal numerical cognition: from reals to integers.

Science.gov (United States)

Gallistel; Gelman

2000-02-01

Data on numerical processing by verbal (human) and non-verbal (animal and human) subjects are integrated by the hypothesis that a non-verbal counting process represents discrete (countable) quantities by means of magnitudes with scalar variability. These appear to be identical to the magnitudes that represent continuous (uncountable) quantities such as duration. The magnitudes representing countable quantity are generated by a discrete incrementing process, which defines next magnitudes and yields a discrete ordering. In the case of continuous quantities, the continuous accumulation process does not define next magnitudes, so the ordering is also continuous ('dense'). The magnitudes representing both countable and uncountable quantity are arithmetically combined in, for example, the computation of the income to be expected from a foraging patch. Thus, on the hypothesis presented here, the primitive machinery for arithmetic processing works with real numbers (magnitudes).

Evidence that non-dreamers do dream: a REM sleep behaviour disorder model.

Science.gov (United States)

Herlin, Bastien; Leu-Semenescu, Smaranda; Chaumereuil, Charlotte; Arnulf, Isabelle

2015-12-01

To determine whether non-dreamers do not produce dreams or do not recall them, subjects were identified with no dream recall with dreamlike behaviours during rapid eye movement sleep behaviour disorder, which is typically characterised by dream-enacting behaviours congruent with sleep mentation. All consecutive patients with idiopathic rapid eye movement sleep behaviour disorder or rapid eye movement sleep behaviour disorder associated with Parkinson's disease who underwent a video-polysomnography were interviewed regarding the presence or absence of dream recall, retrospectively or upon spontaneous arousals. The patients with no dream recall for at least 10 years, and never-ever recallers were compared with dream recallers with rapid eye movement sleep behaviour disorder regarding their clinical, cognitive and sleep features. Of the 289 patients with rapid eye movement sleep behaviour disorder, eight (2.8%) patients had no dream recall, including four (1.4%) patients who had never ever recalled dreams, and four patients who had no dream recall for 10-56 years. All non-recallers exhibited, daily or almost nightly, several complex, scenic and dreamlike behaviours and speeches, which were also observed during rapid eye movement sleep on video-polysomnography (arguing, fighting and speaking). They did not recall a dream following sudden awakenings from rapid eye movement sleep. These eight non-recallers with rapid eye movement sleep behaviour disorder did not differ in terms of cognition, clinical, treatment or sleep measures from the 17 dreamers with rapid eye movement sleep behaviour disorder matched for age, sex and disease. The scenic dreamlike behaviours reported and observed during rapid eye movement sleep in the rare non-recallers with rapid eye movement sleep behaviour disorder (even in the never-ever recallers) provide strong evidence that non-recallers produce dreams, but do not recall them. Rapid eye movement sleep behaviour disorder provides a new model to

Unimodular lattices in dimensions 14 and 15 over the Eisenstein integers

Science.gov (United States)

Abdukhalikov, Kanat; Scharlau, Rudolf

2009-03-01

All indecomposable unimodular hermitian lattices in dimensions 14 and 15 over the ring of integers in mathbb{Q}(sqrt{-3}) are determined. Precisely one lattice in dimension 14 and two lattices in dimension 15 have minimal norm 3.

Mixed-Integer Conic Linear Programming: Challenges and Perspectives

Science.gov (United States)

2013-10-01

The novel DCCs for MISOCO may be used in branch- and-cut algorithms when solving MISOCO problems. The experimental software CICLO was developed to...perform limited, but rigorous computational experiments. The CICLO solver utilizes continuous SOCO solvers, MOSEK, CPLES or SeDuMi, builds on the open...submitted Fall 2013. Software: 1. CICLO : Integer conic linear optimization package. Authors: J.C. Góez, T.K. Ralphs, Y. Fu, and T. Terlaky

A mixed integer linear program for an integrated fishery | Hasan ...

African Journals Online (AJOL)

... and labour allocation of quota based integrated fisheries. We demonstrate the workability of our model with a numerical example and sensitivity analysis based on data obtained from one of the major fisheries in New Zealand. Keywords: mixed integer linear program, fishing, trawler scheduling, processing, quotas ORiON: ...

On the gauge invariant and topological nature of the localization determining the Quantum Hall Effect plateaus

CERN Document Server

Cabo-Montes de Oca, Alejandro

2002-01-01

It is shown how the electromagnetic response of 2DEG under Quantum Hall Effect regime, characterized by the Chern-Simons topological action, transforms the sample impurities and defects in charge-reservoirs that stabilize the Hall conductivity plateaus. The results determine the basic dynamical origin of the singular properties of localization under the occurrence of the Quantum Hall Effect obtained in the pioneering works of Laughlin and of Joynt and Prange, by means of a gauge invariance argument and a purely electronic analysis, respectively. The common intuitive picture of electrons moving along the equipotential lines gets an analytical realization through the Chern-Simons current and charge densities.

IMC-PID-fractional-order-filter controllers design for integer order systems.

Science.gov (United States)

Maâmar, Bettayeb; Rachid, Mansouri

2014-09-01

One of the reasons of the great success of standard PID controllers is the presence of simple tuning rules, of the automatic tuning feature and of tables that simplify significantly their design. For the fractional order case, some tuning rules have been proposed in the literature. However, they are not general because they are valid only for some model cases. In this paper, a new approach is investigated. The fractional property is not especially imposed by the controller structure but by the closed loop reference model. The resulting controller is fractional but it has a very interesting structure for its implementation. Indeed, the controller can be decomposed into two transfer functions: an integer transfer function which is generally an integer PID controller and a simple fractional filter. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

Psychiatric disorders among war-abducted and non-abducted ...

African Journals Online (AJOL)

Psychiatric disorders among war-abducted and non-abducted adolescents in Gulu district, ... Log in or Register to get access to full text downloads. ... and the Mini International Neural-Psychiatric Interview for Children and Adolescents English ...

A new Tevatron Collider working point near the integer

International Nuclear Information System (INIS)

Johnson, R.P.; Zhang, P.

1989-12-01

It is well established that in hadron colliders the beam-beam interaction is more harmful in the presence of machine resonances of the form mν x + nν y = p, where |m| + |n| is the order of the resonance. Since the closest a resonance line can be to the integer stopband is 1/order, the closer the working point is to the integer, the fewer lower order resonances there are to enhance the beam-beam effects. A shift of the working point of the Tevatron from 19.4 to values near 19 and 20 has been studied. Problems with closed orbit control, dispersion matching, and matched low β insertions were considered. An excellent solution for the B0 insertion was found which has an improved β*. A new injection optics allows a transition to the low β optics which is much easier than the one now used. Results from the first machine studies demonstrate the ability to control the orbit with tunes of 19.03 horizontal and 20.03 vertical. Further studies require the activation of additional quadrupole compensation circuits. 4 refs. , 2 figs

Copenhagen's single system premise prevents a unified view of integer and fractional quantum hall effect

Science.gov (United States)

Post, Evert Jan

1999-05-01

This essay presents conclusive evidence of the impermissibility of Copenhagen's single system interpretation of the Schroedinger process. The latter needs to be viewed as a tool exclusively describing phase and orientation randomized ensembles and is not be used for isolated single systems. Asymptotic closeness of single system and ensemble behavior and the rare nature of true single system manifestations have prevented a definitive identification of this Copenhagen deficiency over the past three quarter century. Quantum uncertainty so becomes a basic trade mark of phase and orientation disordered ensembles. The ensuing void of usable single system tools opens a new inquiry for tools without statistical connotations. Three, in part already known, period integrals here identified as flux, charge and action counters emerge as diffeo-4 invariant tools fully compatible with the demands of the general theory of relativity. The discovery of the quantum Hall effect has been instrumental in forcing a distinction between ensemble disorder as in the normal Hall effect versus ensemble order in the plateau states. Since the order of the latter permits a view of the plateau states as a macro- or meso-scopic single system, the period integral description applies, yielding a straightforward unified description of integer and fractional quantum Hall effects.

Sleep disorders and an increased risk of Parkinson's disease in individuals with non-apnea sleep disorders: a population-based cohort study.

Science.gov (United States)

Hsiao, Yi-Han; Chen, Yung-Tai; Tseng, Ching-Ming; Wu, Li-An; Perng, Diahn-Warng; Chen, Yuh-Min; Chen, Tzeng-Ji; Chang, Shi-Chuan; Chou, Kun-Ta

2017-10-01

Sleep disorders are common non-motor symptoms in patients with Parkinson's disease. Our study aims to explore the relationship between non-apnea sleep disorders and future Parkinson's disease. This is a cohort study using a nationwide database. The participants were recruited from the Taiwan National Health Insurance Research Database between 2000 and 2003. A total of 91 273 adult patients who had non-apnea sleep disorders without pre-existing Parkinson's disease were enrolled. An age-, gender-, income-, urbanization- and Charlson comorbidity index score-matched control cohort consisting of 91 273 participants was selected for comparison. The two cohorts were followed for the occurrence of Parkinson's disease, death or until the end of 2010, whichever came first. The Kaplan-Meier analyses revealed patients with non-apnea sleep disorders tended to develop Parkinson's disease (log-rank test, P sleep disorders was an independent risk factor for the development of Parkinson's disease [crude hazard ratio: 1.63, 95% confidence interval (CI): 1.54-1.73, P sleep disorders, especially chronic insomnia, are associated with a higher risk for future Parkinson's disease. © 2017 European Sleep Research Society.

Radiological and clinical characterization of the lysosomal storage disorders: non-lipid disorders.

Science.gov (United States)

Parker, E I; Xing, M; Moreno-De-Luca, A; Harmouche, E; Terk, M R

2014-01-01

Lysosomal storage diseases (LSDs) are a large group of genetic metabolic disorders that result in the accumulation of abnormal material, such as mucopolysaccharides, glycoproteins, amino acids and lipids, within cells. Since many LSDs manifest during infancy or early childhood, with potentially devastating consequences if left untreated, timely identification is imperative to prevent irreversible damage and early death. In this review, the key imaging features of the non-lipid or extralipid LSDs are examined and correlated with salient clinical manifestations and genetic information. Disorders are stratified based on the type of excess material causing tissue or organ dysfunction, with descriptions of the mucopolysaccharidoses, mucolipidoses, alpha-mannosidosis, glycogen storage disorder II and cystinosis. In addition, similarities and differences in radiological findings between each of these LSDs are highlighted to facilitate further recognition. Given the rare and extensive nature of the LSDs, mastery of their multiple clinical and radiological traits may seem challenging. However, an understanding of the distinguishing imaging characteristics of LSDs and their clinical correlates may allow radiologists to play a key role in the early diagnosis of these progressive and potentially fatal disorders.

Solving the Water Jugs Problem by an Integer Sequence Approach

Science.gov (United States)

Man, Yiu-Kwong

2012-01-01

In this article, we present an integer sequence approach to solve the classic water jugs problem. The solution steps can be obtained easily by additions and subtractions only, which is suitable for manual calculation or programming by computer. This approach can be introduced to secondary and undergraduate students, and also to teachers and…

Reduced-Size Integer Linear Programming Models for String Selection Problems: Application to the Farthest String Problem.

Science.gov (United States)

Zörnig, Peter

2015-08-01

We present integer programming models for some variants of the farthest string problem. The number of variables and constraints is substantially less than that of the integer linear programming models known in the literature. Moreover, the solution of the linear programming-relaxation contains only a small proportion of noninteger values, which considerably simplifies the rounding process. Numerical tests have shown excellent results, especially when a small set of long sequences is given.

Sleep-related breathing disorders and non-invasive ventilation

Directory of Open Access Journals (Sweden)

Agata Lax

2015-05-01

Full Text Available Non-invasive mechanical ventilation (NPPV was originally used in patients with acute respiratory impairment or exacerbations of chronic respiratory diseases, as an alternative to the endotracheal tube. Over the last thirty years NPPV has been also used at night in patients with stable chronic lung disease such as obstructive sleep apnea, the overlap syndrome (chronic obstructive pulmonary disease and obstructive sleep apnea, neuromuscular disorders, obesity-hypoventilation syndrome, and in other conditions such as sleep disorders associated with congestive heart failure (Cheyne-Stokes respiration. In this no-systematic review we discuss the different types of NPPV, the specific conditions in which they can be used and the indications, recommendations and evidence supporting the efficacy of NPPV. Optimizing patient acceptance and adherence to non-invasive ventilation treatment is challenging. The treatment of sleep-related disorders is a life-threatening condition. The optimal level of treatment should be determined in a sleep laboratory. Side effects directly affecting the patient’s adherence to treatment are known. The most common are nasopharyngeal symptoms including increased congestion and rhinorrhea; these effects are related to reduced humidity of inspired gas. Humidification of delivered gas may improve these symptoms.

Time-Series INSAR: An Integer Least-Squares Approach For Distributed Scatterers

Science.gov (United States)

Samiei-Esfahany, Sami; Hanssen, Ramon F.

2012-01-01

The objective of this research is to extend the geode- tic mathematical model which was developed for persistent scatterers to a model which can exploit distributed scatterers (DS). The main focus is on the integer least- squares framework, and the main challenge is to include the decorrelation effect in the mathematical model. In order to adapt the integer least-squares mathematical model for DS we altered the model from a single master to a multi-master configuration and introduced the decorrelation effect stochastically. This effect is described in our model by a full covariance matrix. We propose to de- rive this covariance matrix by numerical integration of the (joint) probability distribution function (PDF) of interferometric phases. This PDF is a function of coherence values and can be directly computed from radar data. We show that the use of this model can improve the performance of temporal phase unwrapping of distributed scatterers.

Smart-Grid Backbone Network Real-Time Delay Reduction via Integer Programming.

Science.gov (United States)

Pagadrai, Sasikanth; Yilmaz, Muhittin; Valluri, Pratyush

2016-08-01

This research investigates an optimal delay-based virtual topology design using integer linear programming (ILP), which is applied to the current backbone networks such as smart-grid real-time communication systems. A network traffic matrix is applied and the corresponding virtual topology problem is solved using the ILP formulations that include a network delay-dependent objective function and lightpath routing, wavelength assignment, wavelength continuity, flow routing, and traffic loss constraints. The proposed optimization approach provides an efficient deterministic integration of intelligent sensing and decision making, and network learning features for superior smart grid operations by adaptively responding the time-varying network traffic data as well as operational constraints to maintain optimal virtual topologies. A representative optical backbone network has been utilized to demonstrate the proposed optimization framework whose simulation results indicate that superior smart-grid network performance can be achieved using commercial networks and integer programming.

Application of Integer and Fractional Models in Electrochemical Systems

Directory of Open Access Journals (Sweden)

Isabel S. Jesus

2012-01-01

Full Text Available This paper describes the use of integer and fractional electrical elements, for modelling two electrochemical systems. A first type of system consists of botanical elements and a second type is implemented by electrolyte processes with fractal electrodes. Experimental results are analyzed in the frequency domain, and the pros and cons of adopting fractional-order electrical components for modelling these systems are compared.

Penempatan Optimal Phasor Measurement Unit (PMU) Dengan Integer Programming

OpenAIRE

Amrulloh, Yunan Helmy

2013-01-01

Phasor Measurement Unit (PMU) merupakan peralatan yang mampu memberikan pengukuran fasor tegangan dan arus secara real-time. PMU dapat digunakan untuk monitoring, proteksi dan kontrol pada sistem tenaga listrik. Tugas akhir ini membahas penempatan PMU secara optimal berdasarkan topologi jaringan sehingga sistem tenaga listrik dapat diobservasi. Penempatan optimal PMU dirumuskan sebagai masalah Binary Integer Programming (BIP) yang akan memberikan variabel dengan pilihan nilai (0,1) yang menu...

A CU-Level Rate and Distortion Estimation Scheme for RDO of Hardware-Friendly HEVC Encoders Using Low-Complexity Integer DCTs.

Science.gov (United States)

Lee, Bumshik; Kim, Munchurl

2016-08-01

In this paper, a low complexity coding unit (CU)-level rate and distortion estimation scheme is proposed for High Efficiency Video Coding (HEVC) hardware-friendly implementation where a Walsh-Hadamard transform (WHT)-based low-complexity integer discrete cosine transform (DCT) is employed for distortion estimation. Since HEVC adopts quadtree structures of coding blocks with hierarchical coding depths, it becomes more difficult to estimate accurate rate and distortion values without actually performing transform, quantization, inverse transform, de-quantization, and entropy coding. Furthermore, DCT for rate-distortion optimization (RDO) is computationally high, because it requires a number of multiplication and addition operations for various transform block sizes of 4-, 8-, 16-, and 32-orders and requires recursive computations to decide the optimal depths of CU or transform unit. Therefore, full RDO-based encoding is highly complex, especially for low-power implementation of HEVC encoders. In this paper, a rate and distortion estimation scheme is proposed in CU levels based on a low-complexity integer DCT that can be computed in terms of WHT whose coefficients are produced in prediction stages. For rate and distortion estimation in CU levels, two orthogonal matrices of 4×4 and 8×8 , which are applied to WHT that are newly designed in a butterfly structure only with addition and shift operations. By applying the integer DCT based on the WHT and newly designed transforms in each CU block, the texture rate can precisely be estimated after quantization using the number of non-zero quantized coefficients and the distortion can also be precisely estimated in transform domain without de-quantization and inverse transform required. In addition, a non-texture rate estimation is proposed by using a pseudoentropy code to obtain accurate total rate estimates. The proposed rate and the distortion estimation scheme can effectively be used for HW-friendly implementation of

Some operational tools for solving fractional and higher integer order differential equations: A survey on their mutual relations

Science.gov (United States)

Kiryakova, Virginia S.

2012-11-01

The Laplace Transform (LT) serves as a basis of the Operational Calculus (OC), widely explored by engineers and applied scientists in solving mathematical models for their practical needs. This transform is closely related to the exponential and trigonometric functions (exp, cos, sin) and to the classical differentiation and integration operators, reducing them to simple algebraic operations. Thus, the classical LT and the OC give useful tool to handle differential equations and systems with constant coefficients. Several generalizations of the LT have been introduced to allow solving, in a similar way, of differential equations with variable coefficients and of higher integer orders, as well as of fractional (arbitrary non-integer) orders. Note that fractional order mathematical models are recently widely used to describe better various systems and phenomena of the real world. This paper surveys briefly some of our results on classes of such integral transforms, that can be obtained from the LT by means of "transmutations" which are operators of the generalized fractional calculus (GFC). On the list of these Laplace-type integral transforms, we consider the Borel-Dzrbashjan, Meijer, Krätzel, Obrechkoff, generalized Obrechkoff (multi-index Borel-Dzrbashjan) transforms, etc. All of them are G- and H-integral transforms of convolutional type, having as kernels Meijer's G- or Fox's H-functions. Besides, some special functions (also being G- and H-functions), among them - the generalized Bessel-type and Mittag-Leffler (M-L) type functions, are generating Gel'fond-Leontiev (G-L) operators of generalized differentiation and integration, which happen to be also operators of GFC. Our integral transforms have operational properties analogous to those of the LT - they do algebrize the G-L generalized integrations and differentiations, and thus can serve for solving wide classes of differential equations with variable coefficients of arbitrary, including non-integer order

DESIGN OF DYADIC-INTEGER-COEFFICIENTS BASED BI-ORTHOGONAL WAVELET FILTERS FOR IMAGE SUPER-RESOLUTION USING SUB-PIXEL IMAGE REGISTRATION

Directory of Open Access Journals (Sweden)

P.B. Chopade

2014-05-01

Full Text Available This paper presents image super-resolution scheme based on sub-pixel image registration by the design of a specific class of dyadic-integer-coefficient based wavelet filters derived from the construction of a half-band polynomial. First, the integer-coefficient based half-band polynomial is designed by the splitting approach. Next, this designed half-band polynomial is factorized and assigned specific number of vanishing moments and roots to obtain the dyadic-integer coefficients low-pass analysis and synthesis filters. The possibility of these dyadic-integer coefficients based wavelet filters is explored in the field of image super-resolution using sub-pixel image registration. The two-resolution frames are registered at a specific shift from one another to restore the resolution lost by CCD array of camera. The discrete wavelet transform (DWT obtained from the designed coefficients is applied on these two low-resolution images to obtain the high resolution image. The developed approach is validated by comparing the quality metrics with existing filter banks.

Geometrical meaning of winding number and its characterization of topological phases in one-dimensional chiral non-Hermitian systems

Science.gov (United States)

Yin, Chuanhao; Jiang, Hui; Li, Linhu; Lü, Rong; Chen, Shu

2018-05-01

We unveil the geometrical meaning of winding number and utilize it to characterize the topological phases in one-dimensional chiral non-Hermitian systems. While chiral symmetry ensures the winding number of Hermitian systems are integers, it can take half integers for non-Hermitian systems. We give a geometrical interpretation of the half integers by demonstrating that the winding number ν of a non-Hermitian system is equal to half of the summation of two winding numbers ν1 and ν2 associated with two exceptional points, respectively. The winding numbers ν1 and ν2 represent the times of the real part of the Hamiltonian in momentum space encircling the exceptional points and can only take integers. We further find that the difference of ν1 and ν2 is related to the second winding number or energy vorticity. By applying our scheme to a non-Hermitian Su-Schrieffer-Heeger model and an extended version of it, we show that the topologically different phases can be well characterized by winding numbers. Furthermore, we demonstrate that the existence of left and right zero-mode edge states is closely related to the winding number ν1 and ν2.

Heuristic Methods of Integer Programming and Its Applications in Economics

Directory of Open Access Journals (Sweden)

Dominika Crnjac Milić

2010-12-01

Full Text Available A short overview of the results related to integer programming is described in the introductory part of this paper. Furthermore, there is a list of literature related to this field. The main part of the paper analyses the Heuristic method which yields a very fast result without the use of significant mathematical tools.

On the convex hull of the simple integer recourse objective function

NARCIS (Netherlands)

Klein Haneveld, Willem K.; Stougie, L.; van der Vlerk, Maarten H.

1995-01-01

We consider the objective function of a simple integer recourse problem with fixed technology matrix. Using properties of the expected value function, we prove a relation between the convex hull of this function and the expected value function of a continuous simple recourse program. We present an

Multi-task feature selection in microarray data by binary integer programming.

Science.gov (United States)

Lan, Liang; Vucetic, Slobodan

2013-12-20

A major challenge in microarray classification is that the number of features is typically orders of magnitude larger than the number of examples. In this paper, we propose a novel feature filter algorithm to select the feature subset with maximal discriminative power and minimal redundancy by solving a quadratic objective function with binary integer constraints. To improve the computational efficiency, the binary integer constraints are relaxed and a low-rank approximation to the quadratic term is applied. The proposed feature selection algorithm was extended to solve multi-task microarray classification problems. We compared the single-task version of the proposed feature selection algorithm with 9 existing feature selection methods on 4 benchmark microarray data sets. The empirical results show that the proposed method achieved the most accurate predictions overall. We also evaluated the multi-task version of the proposed algorithm on 8 multi-task microarray datasets. The multi-task feature selection algorithm resulted in significantly higher accuracy than when using the single-task feature selection methods.

Exact solutions to traffic density estimation problems involving the Lighthill-Whitham-Richards traffic flow model using mixed integer programming

KAUST Repository

Canepa, Edward S.; Claudel, Christian G.

2012-01-01

This article presents a new mixed integer programming formulation of the traffic density estimation problem in highways modeled by the Lighthill Whitham Richards equation. We first present an equivalent formulation of the problem using an Hamilton-Jacobi equation. Then, using a semi-analytic formula, we show that the model constraints resulting from the Hamilton-Jacobi equation result in linear constraints, albeit with unknown integers. We then pose the problem of estimating the density at the initial time given incomplete and inaccurate traffic data as a Mixed Integer Program. We then present a numerical implementation of the method using experimental flow and probe data obtained during Mobile Century experiment. © 2012 IEEE.

Exact solutions to traffic density estimation problems involving the Lighthill-Whitham-Richards traffic flow model using mixed integer programming

KAUST Repository

Canepa, Edward S.

2012-09-01

This article presents a new mixed integer programming formulation of the traffic density estimation problem in highways modeled by the Lighthill Whitham Richards equation. We first present an equivalent formulation of the problem using an Hamilton-Jacobi equation. Then, using a semi-analytic formula, we show that the model constraints resulting from the Hamilton-Jacobi equation result in linear constraints, albeit with unknown integers. We then pose the problem of estimating the density at the initial time given incomplete and inaccurate traffic data as a Mixed Integer Program. We then present a numerical implementation of the method using experimental flow and probe data obtained during Mobile Century experiment. © 2012 IEEE.

Zeta functions for the spectrum of the non-commutative harmonic oscillators

CERN Document Server

Ichinose, T

2004-01-01

This paper investigates the spectral zeta function of the non-commutative harmonic oscillator studied in \\cite{PW1, 2}. It is shown, as one of the basic analytic properties, that the spectral zeta function is extended to a meromorphic function in the whole complex plane with a simple pole at $s=1$, and further that it has a zero at all non-positive even integers, i.e. at $s=0$ and at those negative even integers where the Riemann zeta function has the so-called trivial zeros. As a by-product of the study, both the upper and the lower bounds are also given for the first eigenvalue of the non-commutative harmonic oscillator.

Disordered spinor Bose-Hubbard model

International Nuclear Information System (INIS)

LaPcki, Mateusz; Paganelli, Simone; Ahufinger, Veronica; Sanpera, Anna; Zakrzewski, Jakub

2011-01-01

We study the zero-temperature phase diagram of the disordered spin-1 Bose-Hubbard model in a two-dimensional square lattice. To this aim, we use a mean-field Gutzwiller ansatz and a probabilistic mean-field perturbation theory. The spin interaction induces two different regimes, corresponding to a ferromagnetic and antiferromagnetic order. In the ferromagnetic case, the introduction of disorder reproduces analogous features of the disordered scalar Bose-Hubbard model, consisting in the formation of a Bose glass phase between Mott insulator lobes. In the antiferromagnetic regime, the phase diagram differs more from the scalar case. Disorder in the chemical potential can lead to the disappearance of Mott insulator lobes with an odd-integer filling factor and, for sufficiently strong spin coupling, to Bose glass of singlets between even-filling Mott insulator lobes. Disorder in the spinor coupling parameter results in the appearance of a Bose glass phase only between the n and the n+1 lobes for n odd. Disorder in the scalar Hubbard interaction inhibits Mott insulator regions for occupation larger than a critical value.

Solid state NMR, basic theory and recent progress for quadrupole nuclei with half-integer spin

International Nuclear Information System (INIS)

Dieter, F.

1998-01-01

This review describes the basic theory and some recently developed techniques for the study of quadrupole nuclei with half integer spins in powder materials. The latter is connected to the introduction of the double rotation (DOR) by A. Samoson et al. (1) and to the introduction of the multiple quantum magic-angle spinning (MQ MAS) technique by L. Frydman et. al. (2). For integer spins, especially the solid-state deuterium magnetic resonance, we refer to the review of G.L. Hoatson and R.L. Vold: '' 2 H-NMR Spectroscopy of Solids and Liquid Crystals'' (3). For single crystals we refer to O. Kanert and M. Mehring: ''Static quadrupole effects in disordered cubic solids''(4) and we would like also to mention the ''classic'' review of M.H. Cohen and F. Reif: ''Quadrupole effects in NMR studies of solids'' (5). Some more recent reviews in the field under study are D. Freude and J. Haase ''Quadrupole effects in solid-state NMR'' (6). Ch. Jager: ''Satellite Transition Spectroscopy of Quadrupolar Nuclei'' (7) and B.F. Chmelka and J.W. Zwanziger: ''Solid State NMR Line Narrowing Methods for Quadrupolar Nuclei - Double Rotation and Dynamic-Angle Spinning'' (8). A survey of nuclear quadrupole frequency data published before the end of 1982 is given by H. Chihara and N. Nakamura in Landolt-Bornstein, Vol. 20 (9). Values of the chemical shift of quadrupole nuclei in solids can be found in books such as ''Multinuclear NMR'' edited by J. Mason (10). In section 9 of ref (6) some electric field gradient and chemical shift data published from 1983 to 1992 for the most studied quadrupole nuclei sup 27 Al, sup 23 Na, and sup 17 O are given

Accurate Computation of Periodic Regions' Centers in the General M-Set with Integer Index Number

Directory of Open Access Journals (Sweden)

Wang Xingyuan

2010-01-01

Full Text Available This paper presents two methods for accurately computing the periodic regions' centers. One method fits for the general M-sets with integer index number, the other fits for the general M-sets with negative integer index number. Both methods improve the precision of computation by transforming the polynomial equations which determine the periodic regions' centers. We primarily discuss the general M-sets with negative integer index, and analyze the relationship between the number of periodic regions' centers on the principal symmetric axis and in the principal symmetric interior. We can get the centers' coordinates with at least 48 significant digits after the decimal point in both real and imaginary parts by applying the Newton's method to the transformed polynomial equation which determine the periodic regions' centers. In this paper, we list some centers' coordinates of general M-sets' k-periodic regions (k=3,4,5,6 for the index numbers α=−25,−24,…,−1 , all of which have highly numerical accuracy.

Plateaus and sinuous ridges as the fingerprints of lava flow inflation in the Eastern Tharsis Plains of Mars

Science.gov (United States)

Bleacher, Jacob E.; Orr, Tim R.; de Wet, Andrew P.; Zimbelman, James R.; Hamilton, Christopher W.; Brent Garry, W.; Crumpler, Larry S.; Williams, David A.

2017-08-01

The Tharsis Montes rift aprons are composed of outpourings of lava from chaotic terrains to the northeast and southwest flank of each volcano. Sinuous and branching channel networks that are present on the rift aprons suggest the possibility of fluvial processes in their development, or erosion by rapidly emplaced lavas, but the style of lava flow emplacement throughout rift apron development is not clearly understood. To better characterize the style of lava emplacement and role of fluvial processes in rift apron development, we conducted morphological mapping of the Pavonis Mons southwest rift apron and the eastern Tharsis plains using images from the High Resolution Imaging Science Experiment (HiRISE), Mars Orbiter Camera (MOC), Context Camera (CTX), Thermal Emission Imaging System (THEMIS), and High Resolution Stereo Camera (HRSC) along with the Mars Orbiter Laser Altimeter (MOLA) Precision Experiment Data Records (PEDRs) and gridded data. Our approach was to: (1) search for depositional fans at the slope break between the rift apron and adjacent low slope plains; (2) determine if there is evidence that previously formed deposits might have been buried by plains units; (3) characterize the Tharsis plains morphologies east of Pavonis Mons; and (4) assess their relationship to the rift apron units. We have not identified topographically significant depositional fans, nor did we observe evidence to suggest that plains units have buried older rift apron units. Flow features associated with the rift apron are observed to continue across the slope break onto the plains. In this area, the plains are composed of a variety of small fissures and low shield vents around which broad channel-fed and tube-fed flows have been identified. We also find broad, flat-topped plateaus and sinuous ridges mixed among the channels, tubes and vents. Flat-topped plateaus and sinuous ridges are morphologies that are analogous to those observed on the coastal plain of Hawai'i, where lava

Towards Merging Binary Integer Programming Techniques with Genetic Algorithms

Directory of Open Access Journals (Sweden)

Reza Zamani

2017-01-01

Full Text Available This paper presents a framework based on merging a binary integer programming technique with a genetic algorithm. The framework uses both lower and upper bounds to make the employed mathematical formulation of a problem as tight as possible. For problems whose optimal solutions cannot be obtained, precision is traded with speed through substituting the integrality constrains in a binary integer program with a penalty. In this way, instead of constraining a variable u with binary restriction, u is considered as real number between 0 and 1, with the penalty of Mu(1-u, in which M is a large number. Values not near to the boundary extremes of 0 and 1 make the component of Mu(1-u large and are expected to be avoided implicitly. The nonbinary values are then converted to priorities, and a genetic algorithm can use these priorities to fill its initial pool for producing feasible solutions. The presented framework can be applied to many combinatorial optimization problems. Here, a procedure based on this framework has been applied to a scheduling problem, and the results of computational experiments have been discussed, emphasizing the knowledge generated and inefficiencies to be circumvented with this framework in future.

Phonon transmission and thermal conductance in one-dimensional system with on-site potential disorder

International Nuclear Information System (INIS)

Ma Songshan; Xu Hui; Deng Honggui; Yang Bingchu

2011-01-01

The role of on-site potential disorder on phonon transmission and thermal conductance of one-dimensional system is investigated. We found that the on-site potential disorder can lead to the localization of phonons, and has great effect on the phonon transmission and thermal conductance of the system. As on-site potential disorder W increases, the transmission coefficients decrease, and approach zero at the band edges. Corresponding, the thermal conductance decreases drastically, and the curves for thermal conductance exhibit a series of steps and plateaus. Meanwhile, when the on-site potential disorder W is strong enough, the thermal conductance decreases dramatically with the increase of system size N. We also found that the efficiency of reducing thermal conductance by increasing the on-site potential disorder strength is much better than that by increasing the on-site potential's amplitude. - Highlights: → We studied the effect of on-site potential disorder on thermal transport. → Increasing disorder will decrease thermal transport. → Increasing system size will also decrease its thermal conductance. → Increasing disorder is more efficient than other in reducing thermal conductance.

Mindfulness Moderates the Relationship Between Disordered Eating Cognitions and Disordered Eating Behaviors in a Non-Clinical College Sample

OpenAIRE

Masuda, Akihiko; Price, Matthew; Latzman, Robert D.

2012-01-01

Psychological flexibility and mindfulness are two related, but distinct, regulation processes that have been shown to be at the core of psychological wellbeing. The current study investigated whether these two processes independently moderated the association between disordered eating cognitions and psychological distress as well as the relation between disordered eating cognitions and disordered eating behaviors. Non-clinical, ethnically diverse college undergraduates completed a web-based s...

Integer Charge Transfer and Hybridization at an Organic Semiconductor/Conductive Oxide Interface

KAUST Repository

Gruenewald, Marco; Schirra, Laura K.; Winget, Paul; Kozlik, Michael; Ndione, Paul F.; Sigdel, Ajaya K.; Berry, Joseph J.; Forker, Roman; Bredas, Jean-Luc; Fritz, Torsten; Monti, Oliver L. A.

2015-01-01

with localized states (the shallow donors) in the substrate and charge back-donation, resulting in an effectively integer charge transfer across the interface. Charge transfer is thus not merely a question of locating the Fermi level above the PTCDA electron

Applications exponential approximation by integer shifts of Gaussian functions

Directory of Open Access Journals (Sweden)

S. M. Sitnik

2013-01-01

Full Text Available In this paper we consider approximations of functions using integer shifts of Gaussians – quadratic exponentials. A method is proposed to find coefficients of node functions by solving linear systems of equations. The explicit formula for the determinant of the system is found, based on it solvability of linear system under consideration is proved and uniqueness of its solution. We compare results with known ones and briefly indicate applications to signal theory.

Binary integer programming solution for troubleshooting with dependent actions

Czech Academy of Sciences Publication Activity Database

Lín, Václav

2017-01-01

Roč. 53, č. 3 (2017), s. 493-512 ISSN 0023-5954 R&D Projects: GA ČR GA13-20012S Institutional support: RVO:67985556 Keywords : binary integer programming * decision-theoretic troubleshooting Subject RIV: JD - Computer Applications, Robotics OBOR OECD: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) Impact factor: 0.379, year: 2016 http://library.utia.cas.cz/separaty/2017/MTR/lin-0476547.pdf

Sheaves in Elementary Mathematics: The case of positive integer numbers

OpenAIRE

Luna-Torres, Joaquin

2015-01-01

We aim to use the concept of sheaf to establish a link between certain aspects of the set of positive integers numbers, a topic corresponding to the elementary mathematics, and some fundamental ideas of contemporary mathematics. We hope that this type of approach helps the school students to restate some problems of elementary mathematics in an environment deeper and suitable for its study.

A note on a model for quay crane scheduling with non-crossing constraints

DEFF Research Database (Denmark)

Santini, Alberto; Friberg, Henrik Alsing; Røpke, Stefan

2015-01-01

This article studies the quay crane scheduling problem with non-crossing constraints, which is an operational problem that arises in container terminals. An enhancement to a mixed integer programming model for the problem is proposed and a new class of valid inequalities is introduced. Computatio......This article studies the quay crane scheduling problem with non-crossing constraints, which is an operational problem that arises in container terminals. An enhancement to a mixed integer programming model for the problem is proposed and a new class of valid inequalities is introduced...

An n -material thresholding method for improving integerness of solutions in topology optimization

International Nuclear Information System (INIS)

Watts, Seth; Engineering); Tortorelli, Daniel A.; Engineering)

2016-01-01

It is common in solving topology optimization problems to replace an integer-valued characteristic function design field with the material volume fraction field, a real-valued approximation of the design field that permits "fictitious" mixtures of materials during intermediate iterations in the optimization process. This is reasonable so long as one can interpolate properties for such materials and so long as the final design is integer valued. For this purpose, we present a method for smoothly thresholding the volume fractions of an arbitrary number of material phases which specify the design. This method is trivial for two-material design problems, for example, the canonical topology design problem of specifying the presence or absence of a single material within a domain, but it becomes more complex when three or more materials are used, as often occurs in material design problems. We take advantage of the similarity in properties between the volume fractions and the barycentric coordinates on a simplex to derive a thresholding, method which is applicable to an arbitrary number of materials. As we show in a sensitivity analysis, this method has smooth derivatives, allowing it to be used in gradient-based optimization algorithms. Finally, we present results, which show synergistic effects when used with Solid Isotropic Material with Penalty and Rational Approximation of Material Properties material interpolation functions, popular methods of ensuring integerness of solutions.

Declarative and Non-declarative Memory Consolidation in Children with Sleep Disorder.

Science.gov (United States)

Csábi, Eszter; Benedek, Pálma; Janacsek, Karolina; Zavecz, Zsófia; Katona, Gábor; Nemeth, Dezso

2015-01-01

Healthy sleep is essential in children's cognitive, behavioral, and emotional development. However, remarkably little is known about the influence of sleep disorders on different memory processes in childhood. Such data could give us a deeper insight into the effect of sleep on the developing brain and memory functions and how the relationship between sleep and memory changes from childhood to adulthood. In the present study we examined the effect of sleep disorder on declarative and non-declarative memory consolidation by testing children with sleep-disordered breathing (SDB) which is characterized by disrupted sleep structure. We used a story recall task to measure declarative memory and Alternating Serial Reaction time (ASRT) task to assess non-declarative memory. This task enables us to measure two aspects of non-declarative memory, namely general motor skill learning and sequence-specific learning. There were two sessions: a learning phase and a testing phase, separated by a 12 h offline period with sleep. Our data showed that children with SDB exhibited a generally lower declarative memory performance both in the learning and testing phase; however, both the SDB and control groups exhibited retention of the previously recalled items after the offline period. Here we showed intact non-declarative consolidation in SDB group in both sequence-specific and general motor skill. These findings suggest that sleep disorders in childhood have a differential effect on different memory processes (online vs. offline) and give us insight into how sleep disturbances affects developing brain.

Integer programming of cement distribution by train

Science.gov (United States)

Indarsih

2018-01-01

Cement industry in Central Java distributes cement by train to meet daily demand in Yogyakarta and Central Java area. There are five destination stations. For each destination station, there is a warehouse to load cements. Decision maker of cement industry have a plan to redesign the infrastructure and transportation system. The aim is to determine how many locomotives, train wagons, and containers and how to arrange train schedules with subject to the delivery time. For this purposes, we consider an integer programming to minimize the total of operational cost. Further, we will discuss a case study and the solution the problem can be calculated by LINGO software.

Non-equilibrium Green's functions method: Non-trivial and disordered leads

Science.gov (United States)

He, Yu; Wang, Yu; Klimeck, Gerhard; Kubis, Tillmann

2014-11-01

The non-equilibrium Green's function algorithm requires contact self-energies to model charge injection and extraction. All existing approaches assume infinitely periodic leads attached to a possibly quite complex device. This contradicts today's realistic devices in which contacts are spatially inhomogeneous, chemically disordered, and impacting the overall device characteristics. This work extends the complex absorbing potentials method for arbitrary, ideal, or non-ideal leads in atomistic tight binding representation. The algorithm is demonstrated on a Si nanowire with periodic leads, a graphene nanoribbon with trumpet shape leads, and devices with leads of randomly alloyed Si0.5Ge0.5. It is found that alloy randomness in the leads can reduce the predicted ON-state current of Si0.5Ge0.5 transistors by 45% compared to conventional lead methods.

Mindfulness Moderates the Relationship Between Disordered Eating Cognitions and Disordered Eating Behaviors in a Non-Clinical College Sample.

Science.gov (United States)

Masuda, Akihiko; Price, Matthew; Latzman, Robert D

2012-03-01

Psychological flexibility and mindfulness are two related, but distinct, regulation processes that have been shown to be at the core of psychological wellbeing. The current study investigated whether these two processes independently moderated the association between disordered eating cognitions and psychological distress as well as the relation between disordered eating cognitions and disordered eating behaviors. Non-clinical, ethnically diverse college undergraduates completed a web-based survey. Of 278 participants (nfemale=208; nmale=70) aged 18-24 years old, disordered eating cognitions, mindfulness, and psychological flexibility were related to psychological distress after controlling for gender, ethnicity, and body mass index. Disordered eating cognitions and mindfulness accounted for unique variance in disordered eating behaviors. Finally, mindfulness was found to moderate the association between disordered eating cognitions and disordered eating behaviors.

CBLIB 2014: a benchmark library for conic mixed-integer and continuous optimization

DEFF Research Database (Denmark)

Friberg, Henrik Alsing

2016-01-01

The Conic Benchmark Library is an ongoing community-driven project aiming to challenge commercial and open source solvers on mainstream cone support. In this paper, 121 mixed-integer and continuous second-order cone problem instances have been selected from 11 categories as representative...

Mixed-integer nonlinear approach for the optimal scheduling of a head-dependent hydro chain

Energy Technology Data Exchange (ETDEWEB)

Catalao, J.P.S.; Pousinho, H.M.I. [Department of Electromechanical Engineering, University of Beira Interior, R. Fonte do Lameiro, 6201-001 Covilha (Portugal); Mendes, V.M.F. [Department of Electrical Engineering and Automation, Instituto Superior de Engenharia de Lisboa, R. Conselheiro Emidio Navarro, 1950-062 Lisbon (Portugal)

2010-08-15

This paper is on the problem of short-term hydro scheduling (STHS), particularly concerning a head-dependent hydro chain. We propose a novel mixed-integer nonlinear programming (MINLP) approach, considering hydroelectric power generation as a nonlinear function of water discharge and of the head. As a new contribution to earlier studies, we model the on-off behavior of the hydro plants using integer variables, in order to avoid water discharges at forbidden areas. Thus, an enhanced STHS is provided due to the more realistic modeling presented in this paper. Our approach has been applied successfully to solve a test case based on one of the Portuguese cascaded hydro systems with a negligible computational time requirement. (author)

Split diversity in constrained conservation prioritization using integer linear programming.

Science.gov (United States)

Chernomor, Olga; Minh, Bui Quang; Forest, Félix; Klaere, Steffen; Ingram, Travis; Henzinger, Monika; von Haeseler, Arndt

2015-01-01

Phylogenetic diversity (PD) is a measure of biodiversity based on the evolutionary history of species. Here, we discuss several optimization problems related to the use of PD, and the more general measure split diversity (SD), in conservation prioritization.Depending on the conservation goal and the information available about species, one can construct optimization routines that incorporate various conservation constraints. We demonstrate how this information can be used to select sets of species for conservation action. Specifically, we discuss the use of species' geographic distributions, the choice of candidates under economic pressure, and the use of predator-prey interactions between the species in a community to define viability constraints.Despite such optimization problems falling into the area of NP hard problems, it is possible to solve them in a reasonable amount of time using integer programming. We apply integer linear programming to a variety of models for conservation prioritization that incorporate the SD measure.We exemplarily show the results for two data sets: the Cape region of South Africa and a Caribbean coral reef community. Finally, we provide user-friendly software at http://www.cibiv.at/software/pda.

Mixed integer linear programming model for dynamic supplier selection problem considering discounts

Directory of Open Access Journals (Sweden)

Adi Wicaksono Purnawan

2018-01-01

Full Text Available Supplier selection is one of the most important elements in supply chain management. This function involves evaluation of many factors such as, material costs, transportation costs, quality, delays, supplier capacity, storage capacity and others. Each of these factors varies with time, therefore, supplier identified for one period is not necessarily be same for the next period to supply the same product. So, mixed integer linear programming (MILP was developed to overcome the dynamic supplier selection problem (DSSP. In this paper, a mixed integer linear programming model is built to solve the lot-sizing problem with multiple suppliers, multiple periods, multiple products and quantity discounts. The buyer has to make a decision for some products which will be supplied by some suppliers for some periods cosidering by discount. To validate the MILP model with randomly generated data. The model is solved by Lingo 16.

Raw material utilization in slaughterhouses – optimizing expected profit using mixed-integer programming

DEFF Research Database (Denmark)

Jensen, Toke Koldborg; Kjærsgaard, Niels Christian

Slaughterhouses are major players in the pork supply chain, and supply and demand must be matched in order to generate the highest profit. In particular, carcasses must be sorted in order to produce the “right” final products from the “right” carcasses. We develop a mixed-integer programming (MIP) ...... at slaughterhouses. Finally, we comment on the expected effect of variations in the raw material supply and the demand as well as future research concerning joint modelling of supply chain aspects.......Slaughterhouses are major players in the pork supply chain, and supply and demand must be matched in order to generate the highest profit. In particular, carcasses must be sorted in order to produce the “right” final products from the “right” carcasses. We develop a mixed-integer programming (MIP...

A hybrid Constraint Programming/Mixed Integer Programming framework for the preventive signaling maintenance crew scheduling problem

DEFF Research Database (Denmark)

Pour, Shahrzad M.; Drake, John H.; Ejlertsen, Lena Secher

2017-01-01

A railway signaling system is a complex and interdependent system which should ensure the safe operation of trains. We introduce and address a mixed integer optimisation model for the preventive signal maintenance crew scheduling problem in the Danish railway system. The problem contains many...... to feed as ‘warm start’ solutions to a Mixed Integer Programming (MIP) solver for further optimisation. We apply the CP/MIP framework to a section of the Danish rail network and benchmark our results against both direct application of a MIP solver and modelling the problem as a Constraint Optimisation...

Polynomial selection in number field sieve for integer factorization

Directory of Open Access Journals (Sweden)

Gireesh Pandey

2016-09-01

Full Text Available The general number field sieve (GNFS is the fastest algorithm for factoring large composite integers which is made up by two prime numbers. Polynomial selection is an important step of GNFS. The asymptotic runtime depends on choice of good polynomial pairs. In this paper, we present polynomial selection algorithm that will be modelled with size and root properties. The correlations between polynomial coefficient and number of relations have been explored with experimental findings.

Relaxation and decomposition methods for mixed integer nonlinear programming

CERN Document Server

Nowak, Ivo; Bank, RE

2005-01-01

This book presents a comprehensive description of efficient methods for solving nonconvex mixed integer nonlinear programs, including several numerical and theoretical results, which are presented here for the first time. It contains many illustrations and an up-to-date bibliography. Because on the emphasis on practical methods, as well as the introduction into the basic theory, the book is accessible to a wide audience. It can be used both as a research and as a graduate text.

First time evidence of pronounced plateaus right above the Coulomb barrier in 8Li + 4He fusion

Directory of Open Access Journals (Sweden)

A. Del Zoppo

2016-02-01

Full Text Available We investigate unprecedented experimental information on the fusion reaction induced by the radioactive projectile 8Li on a 4He gas target, at center-of-mass energies between 0.6 and 5 MeV. The main issue is the tendency of the dimensionless fusion cross section σfπƛ2 to form well visible plateaus alternated to steep rises. This finding is likely to be the most genuine consequence of the discrete nature of the intervening angular momenta observed so far in fusion reactions right above the Coulomb barrier. A partial-wave analysis, exclusively based on a pure quantal penetration fusion model and sensitive to the interaction potential, identifies a remarkably low-height barrier.

Multiplicity of summands in the random partitions of an integer

Indian Academy of Sciences (India)

We prove that the probability that there is a summand of multiplicity j in any randomly chosen partition or composition of an integer n goes to zero asymptotically with n provided j is larger than a critical value. As a corollary, we strengthen a result due to Erdös and Lehner (Duke. Math. J. 8 (1941) 335–345) that concerns the ...

Anxiety disorders among Mexican Americans and non-Hispanic whites in Los Angeles.

Science.gov (United States)

Karno, M; Golding, J M; Burnam, M A; Hough, R L; Escobar, J I; Wells, K M; Boyer, R

1989-04-01

This report from the Los Angeles site of the NIMH Epidemiologic Catchment Area study reveals significant ethnic and national origin differences in lifetime prevalence rates for three out of six specific, DSM-III-defined anxiety disorders. In the case of simple phobia, United States-born Mexican Americans report higher rates than native non-Hispanic whites or immigrant Mexican Americans, the latter two groups having similar rates. Mexican Americans born in the United States had higher rates of agoraphobia than immigrant Mexican Americans, and non-Hispanic whites reported higher lifetime rates of generalized anxiety disorder compared with both immigrant and native Mexican Americans. Neither ethnic nor national origin differences in lifetime prevalence rates were found for panic disorder, social phobia, and obsessive-compulsive disorder. Selective migration is postulated as a potential factor influencing prevalence differences between native and immigrant Mexican Americans.

Learning decision trees with flexible constraints and objectives using integer optimization

NARCIS (Netherlands)

Verwer, S.; Zhang, Y.

2017-01-01

We encode the problem of learning the optimal decision tree of a given depth as an integer optimization problem. We show experimentally that our method (DTIP) can be used to learn good trees up to depth 5 from data sets of size up to 1000. In addition to being efficient, our new formulation allows

An Improved Method for Solving Multiobjective Integer Linear Fractional Programming Problem

Directory of Open Access Journals (Sweden)

Meriem Ait Mehdi

2014-01-01

Full Text Available We describe an improvement of Chergui and Moulaï’s method (2008 that generates the whole efficient set of a multiobjective integer linear fractional program based on the branch and cut concept. The general step of this method consists in optimizing (maximizing without loss of generality one of the fractional objective functions over a subset of the original continuous feasible set; then if necessary, a branching process is carried out until obtaining an integer feasible solution. At this stage, an efficient cut is built from the criteria’s growth directions in order to discard a part of the feasible domain containing only nonefficient solutions. Our contribution concerns firstly the optimization process where a linear program that we define later will be solved at each step rather than a fractional linear program. Secondly, local ideal and nadir points will be used as bounds to prune some branches leading to nonefficient solutions. The computational experiments show that the new method outperforms the old one in all the treated instances.

Learning oncogenetic networks by reducing to mixed integer linear programming.

Science.gov (United States)

Shahrabi Farahani, Hossein; Lagergren, Jens

2013-01-01

Cancer can be a result of accumulation of different types of genetic mutations such as copy number aberrations. The data from tumors are cross-sectional and do not contain the temporal order of the genetic events. Finding the order in which the genetic events have occurred and progression pathways are of vital importance in understanding the disease. In order to model cancer progression, we propose Progression Networks, a special case of Bayesian networks, that are tailored to model disease progression. Progression networks have similarities with Conjunctive Bayesian Networks (CBNs) [1],a variation of Bayesian networks also proposed for modeling disease progression. We also describe a learning algorithm for learning Bayesian networks in general and progression networks in particular. We reduce the hard problem of learning the Bayesian and progression networks to Mixed Integer Linear Programming (MILP). MILP is a Non-deterministic Polynomial-time complete (NP-complete) problem for which very good heuristics exists. We tested our algorithm on synthetic and real cytogenetic data from renal cell carcinoma. We also compared our learned progression networks with the networks proposed in earlier publications. The software is available on the website https://bitbucket.org/farahani/diprog.

Declarative and non-declarative memory consolidation in children with sleep disorder

Directory of Open Access Journals (Sweden)

Eszter eCsabi

2016-01-01

Full Text Available Healthy sleep is essential in children’s cognitive, behavioral, and emotional development. However, remarkably little is known about the influence of sleep disorders on different memory processes in childhood. Such data could give us a deeper insight into the effect of sleep on the developing brain and memory functions and how the relationship between sleep and memory changes from childhood to adulthood. In the present study we examined the effect of sleep disorder on declarative and non-declarative memory consolidation by testing children with sleep-disordered breathing (SDB which is characterized by disrupted sleep structure. We used a story recall task to measure declarative memory and Alternating Serial Reaction Time (ASRT task to assess non-declarative memory. This task enables us to measure two aspects of non-declarative memory, namely general motor skill learning and sequence-specific learning. There were two sessions: a learning phase and a testing phase, separated by a 12-hour offline period with sleep. Our data showed that children with SDB exhibited a generally lower declarative memory performance both in the learning and testing phase; however, both the SDB and control groups exhibited retention of the previously recalled items after the offline period. Here we showed intact non-declarative consolidation in SDB group in both sequence-specific and general motor skill. These findings suggest that sleep disorders in childhood have a differential effect on different memory processes (online vs. offline and give us insight into how sleep disturbances affects developing brain.

Determining on-fault earthquake magnitude distributions from integer programming

Science.gov (United States)

Geist, Eric L.; Parsons, Thomas E.

2018-01-01

Earthquake magnitude distributions among faults within a fault system are determined from regional seismicity and fault slip rates using binary integer programming. A synthetic earthquake catalog (i.e., list of randomly sampled magnitudes) that spans millennia is first formed, assuming that regional seismicity follows a Gutenberg-Richter relation. Each earthquake in the synthetic catalog can occur on any fault and at any location. The objective is to minimize misfits in the target slip rate for each fault, where slip for each earthquake is scaled from its magnitude. The decision vector consists of binary variables indicating which locations are optimal among all possibilities. Uncertainty estimates in fault slip rates provide explicit upper and lower bounding constraints to the problem. An implicit constraint is that an earthquake can only be located on a fault if it is long enough to contain that earthquake. A general mixed-integer programming solver, consisting of a number of different algorithms, is used to determine the optimal decision vector. A case study is presented for the State of California, where a 4 kyr synthetic earthquake catalog is created and faults with slip ≥3 mm/yr are considered, resulting in >106  variables. The optimal magnitude distributions for each of the faults in the system span a rich diversity of shapes, ranging from characteristic to power-law distributions. 

LOW COMPLEXITY HYBRID LOSSY TO LOSSLESS IMAGE CODER WITH COMBINED ORTHOGONAL POLYNOMIALS TRANSFORM AND INTEGER WAVELET TRANSFORM

Directory of Open Access Journals (Sweden)

R. Krishnamoorthy

2012-05-01

Full Text Available In this paper, a new lossy to lossless image coding scheme combined with Orthogonal Polynomials Transform and Integer Wavelet Transform is proposed. The Lifting Scheme based Integer Wavelet Transform (LS-IWT is first applied on the image in order to reduce the blocking artifact and memory demand. The Embedded Zero tree Wavelet (EZW subband coding algorithm is used in this proposed work for progressive image coding which achieves efficient bit rate reduction. The computational complexity of lower subband coding of EZW algorithm is reduced in this proposed work with a new integer based Orthogonal Polynomials transform coding. The normalization and mapping are done on the subband of the image for exploiting the subjective redundancy and the zero tree structure is obtained for EZW coding and so the computation complexity is greatly reduced in this proposed work. The experimental results of the proposed technique also show that the efficient bit rate reduction is achieved for both lossy and lossless compression when compared with existing techniques.

A binary mixed integer coded genetic algorithm for multi-objective optimization of nuclear research reactor fuel reloading

Energy Technology Data Exchange (ETDEWEB)

Binh, Do Quang [University of Technical Education Ho Chi Minh City (Viet Nam); Huy, Ngo Quang [University of Industry Ho Chi Minh City (Viet Nam); Hai, Nguyen Hoang [Centre for Research and Development of Radiation Technology, Ho Chi Minh City (Viet Nam)

2014-12-15

This paper presents a new approach based on a binary mixed integer coded genetic algorithm in conjunction with the weighted sum method for multi-objective optimization of fuel loading patterns for nuclear research reactors. The proposed genetic algorithm works with two types of chromosomes: binary and integer chromosomes, and consists of two types of genetic operators: one working on binary chromosomes and the other working on integer chromosomes. The algorithm automatically searches for the most suitable weighting factors of the weighting function and the optimal fuel loading patterns in the search process. Illustrative calculations are implemented for a research reactor type TRIGA MARK II loaded with the Russian VVR-M2 fuels. Results show that the proposed genetic algorithm can successfully search for both the best weighting factors and a set of approximate optimal loading patterns that maximize the effective multiplication factor and minimize the power peaking factor while satisfying operational and safety constraints for the research reactor.

A binary mixed integer coded genetic algorithm for multi-objective optimization of nuclear research reactor fuel reloading

International Nuclear Information System (INIS)

Binh, Do Quang; Huy, Ngo Quang; Hai, Nguyen Hoang

2014-01-01

This paper presents a new approach based on a binary mixed integer coded genetic algorithm in conjunction with the weighted sum method for multi-objective optimization of fuel loading patterns for nuclear research reactors. The proposed genetic algorithm works with two types of chromosomes: binary and integer chromosomes, and consists of two types of genetic operators: one working on binary chromosomes and the other working on integer chromosomes. The algorithm automatically searches for the most suitable weighting factors of the weighting function and the optimal fuel loading patterns in the search process. Illustrative calculations are implemented for a research reactor type TRIGA MARK II loaded with the Russian VVR-M2 fuels. Results show that the proposed genetic algorithm can successfully search for both the best weighting factors and a set of approximate optimal loading patterns that maximize the effective multiplication factor and minimize the power peaking factor while satisfying operational and safety constraints for the research reactor.

A Method of Determination of an Acquisition Program in Order to Maximize the Total Utility Using Linear Programming in Integer Numbers

Directory of Open Access Journals (Sweden)

Alin Cristian Ioan

2010-03-01

Full Text Available This paper solves in a different way the problem of maximization of the total utility using the linear programming in integer numbers. The author uses the diofantic equations (equations in integers numbers and after a decomposing in different cases, he obtains the maximal utility.

Thwarted interpersonal needs and suicide ideation: Comparing psychiatric inpatients with bipolar and non-bipolar mood disorders.

Science.gov (United States)

Taylor, Nathanael J; Mitchell, Sean M; Roush, Jared F; Brown, Sarah L; Jahn, Danielle R; Cukrowicz, Kelly C

2016-12-30

Psychiatric inpatients are at heightened risk for suicide, and evidence suggests that psychiatric inpatients with bipolar mood disorders may be at greater risk for suicide ideation compared to those with non-bipolar mood disorders. There is a paucity of research directly comparing risk factors for suicide ideation in bipolar versus non-bipolar mood disorders in an inpatient sample. The current study sought to clarify the association between two constructs from the interpersonal theory of suicide (i.e., perceived burdensomeness and thwarted belongingness) in leading to suicide ideation among psychiatric inpatients with bipolar and non-bipolar mood disorders. Participants were (N=90) psychiatric inpatients with a bipolar (n = 20) or non-bipolar mood disorder (n=70; per their medical charts). Perceived burdensomeness, but not thwarted belongingness, was significantly associated with suicide ideation after adjusting for other covariates. This suggests perceived burdensomeness may play a key role in suicide ideation among psychiatric inpatients with any mood disorder and highlights the importance of assessment and intervention of perceived burdensomeness in this population. Contrary to our hypothesis, mood disorder group (i.e., bipolar versus non-bipolar) did not moderate the relations between perceived burdensomeness/thwarted belongingness and suicide ideation. Published by Elsevier Ireland Ltd.

Integer Charge Transfer and Hybridization at an Organic Semiconductor/Conductive Oxide Interface

KAUST Repository

Gruenewald, Marco

2015-02-11

We investigate the prototypical hybrid interface formed between PTCDA and conductive n-doped ZnO films by means of complementary optical and electronic spectroscopic techniques. We demonstrate that shallow donors in the vicinity of the ZnO surface cause an integer charge transfer to PTCDA, which is clearly restricted to the first monolayer. By means of DFT calculations, we show that the experimental signatures of the anionic PTCDA species can be understood in terms of strong hybridization with localized states (the shallow donors) in the substrate and charge back-donation, resulting in an effectively integer charge transfer across the interface. Charge transfer is thus not merely a question of locating the Fermi level above the PTCDA electron-transport level but requires rather an atomistic understanding of the interfacial interactions. The study reveals that defect sites and dopants can have a significant influence on the specifics of interfacial coupling and thus on carrier injection or extraction.

Testosterone metabolism in the estuarine mysid Neomysis integer (Crustacea; Mysidacea) following tributyltin exposure.

Science.gov (United States)

Verslycke, Tim; Poelmans, Sofie; De Wasch, Katia; Vercauteren, Jordy; Devos, Christophe; Moens, Luc; Sandra, Patrick; De Brabander, Hubert F; Janssen, Colin R

2003-09-01

Current evidence suggests that the biocide tributyltin (TBT) causes the development of imposex, a state of pseudohermaphrodism in which females exhibit functional secondary male characteristics, by altering the biotransformation or elimination of testosterone. Imposex in gastropods following TBT exposure is the most complete example of the effects of an endocrine disrupter on marine invertebrates. Previous studies have demonstrated that the estuarine mysid Neomysis integer converts testosterone into multiple polar and nonpolar metabolites resulting from both phase I and phase II biotransformations. In this study, the effects of TBT chloride (TBTCl) on the phase I and II testosterone metabolism of N. integer were evaluated. The TBTCl was highly toxic to N. integer (96-h median lethal concentration [LC50] of 164 ng/L). To assess the effects on testosterone metabolism, mysids were exposed for 96 h to different concentrations of TBTCl (control, 10, 100, and 1,000 ng/L), and testosterone elimination as polar hydroxylated, nonpolar oxido-reduced, and glucose- and sulfate-conjugated metabolites was examined. The TBTCl differentially affected testosterone metabolism. The effect of TBTCl on phase I metabolism was unclear and has been shown to vary among species, likely depending on the inducibility or presence of certain P450 isozyme families. Reductase activity and metabolic androgenization were induced in the 10-ng/L treatment, whereas higher concentrations resulted in a reduction of sulfate conjugation. The exact mechanisms underlying TBT-induced imposex and alterations in the steroid metabolism need to be further elucidated.

A Mixed Integer Programming for Port Anzali Development Plan

OpenAIRE

Mahdieh Allahviranloo

2009-01-01

This paper introduces a mixed integer programming model to find the optimum development plan for port Anzali. The model minimizes total system costs taking into account both port infrastructure costs and shipping costs. Due to the multipurpose function of the port, the model consists of 1020 decision variables and 2490 constraints. Results of the model determine the optimum number of berths that should be constructed in each period and for each type of cargo. In addition to, the results of se...

Radiotherapy for non-malignant disorders

International Nuclear Information System (INIS)

Seegenschmiedt, Michael Heinrich; Makoski, Hans-Bruno; Trott, Klaus-Ruediger; Brady, Luther W.

2008-01-01

This volume discusses the general background, radiobiology, radiophysics and clinical applications of radiation therapy in the treatment of non-malignant diseases. Within 39 chapters, it documents the rationale and indications for the use of state-of-the-art radiotherapy for various non-malignant disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and the vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases. With the assistance of many tables and colored figures, the extensive data from clinical studies are presented in a well-structured and informative way. Each chapter concludes with a list of key points, allowing the reader to quickly comprehend the main facts. Since this approach offers an interdisciplinary perspective, this book will be of interest not only to radiotherapists but also to many other practitioners and medical specialists, for example orthopedists, surgeons, and ophthalmologists. (orig.)

Complex dynamics of the integer quantum Hall effect

International Nuclear Information System (INIS)

Trugman, S.A.; Nicopoulos, V.N.; Florida Univ., Gainesville, FL

1991-01-01

We investigate both classical and quantum potential scattering in two dimensions in a magnetic field, with applications to the integer quantum Hall effect. Classical scattering is complex, due in one case to the approach of scattering states to an infinite number of bound states. We show that bound states are generic, and occur for all but extremely smooth scattering potentials (|rvec ∇| → 0). Quantum scattering follows the classical behavior rather closely, exhibiting sharp resonances rather than classical bound states. Extended scatterers provide an explanation for the breakdown of the QHE at a comparatively small Hall voltage. 16 refs., 14 figs

Rate processes with non-Markovian dynamical disorder

International Nuclear Information System (INIS)

Goychuk, Igor

2005-01-01

Rate processes with dynamical disorder are investigated within a simple framework provided by unidirectional electron transfer (ET) with fluctuating transfer rate. The rate fluctuations are assumed to be described by a non-Markovian stochastic jump process which reflects conformational dynamics of an electron transferring donor-acceptor molecular complex. A tractable analytical expression is obtained for the relaxation of the donor population (in the Laplace-transformed time domain) averaged over the stationary conformational fluctuations. The corresponding mean transfer time is also obtained in an analytical form. The case of two-state fluctuations is studied in detail for a model incorporating substate diffusion within one of the conformations. It is shown that an increase of the conformational diffusion time results in a gradual transition from the regime of fast modulation characterized by the averaged ET rate to the regime of quasistatic disorder. This transition occurs at the conformational mean residence time intervals fixed much less than the inverse of the corresponding ET rates. An explanation of this paradoxical effect is provided. Moreover, its presence is also manifested for the simplest, exactly solvable non-Markovian model with a biexponential distribution of the residence times in one of the conformations. The nontrivial conditions for this phenomenon to occur are found

Attention network functioning in children with anxiety disorders, attention-deficit/hyperactivity disorder and non-clinical anxiety.

Science.gov (United States)

Mogg, K; Salum, G A; Bradley, B P; Gadelha, A; Pan, P; Alvarenga, P; Rohde, L A; Pine, D S; Manfro, G G

2015-01-01

Research with adults suggests that anxiety is associated with poor control of executive attention. However, in children, it is unclear (a) whether anxiety disorders and non-clinical anxiety are associated with deficits in executive attention, (b) whether such deficits are specific to anxiety versus other psychiatric disorders, and (c) whether there is heterogeneity among anxiety disorders (in particular, specific phobia versus other anxiety disorders). We examined executive attention in 860 children classified into three groups: anxiety disorders (n = 67), attention-deficit/hyperactivity disorder (ADHD; n = 67) and no psychiatric disorder (n = 726). Anxiety disorders were subdivided into: anxiety disorders excluding specific phobia (n = 43) and specific phobia (n = 21). The Attention Network Task was used to assess executive attention, alerting and orienting. Findings indicated heterogeneity among anxiety disorders, as children with anxiety disorders (excluding specific phobia) showed impaired executive attention, compared with disorder-free children, whereas children with specific phobia showed no executive attention deficit. Among disorder-free children, executive attention was less efficient in those with high, relative to low, levels of anxiety. There were no anxiety-related deficits in orienting or alerting. Children with ADHD not only had poorer executive attention than disorder-free children, but also higher orienting scores, less accurate responses and more variable response times. Impaired executive attention in children (reflected by difficulty inhibiting processing of task-irrelevant information) was not fully explained by general psychopathology, but instead showed specific associations with anxiety disorders (other than specific phobia) and ADHD, as well as with high levels of anxiety symptoms in disorder-free children.

Positive integer solutions of the diophantine equation x2 −Lnxy +(−1 ...

Indian Academy of Sciences (India)

ny2 = ±5r when the equation has positive integer solutions. Keywords. Fibonacci numbers; Lucas numbers; diophantine equations. Mathematics Subject Classification. 11B37, 11B39. 1. Introduction. The Fibonacci sequence {Fn} is defined by F0 ...

On Secure Two-Party Integer Division

DEFF Research Database (Denmark)

Dahl, Morten; Ning, Chao; Toft, Tomas

2012-01-01

{\\mathcal{O}}(\\ell)$ arithmetic operations on encrypted values (secure addition and multiplication) in $\\ensuremath{\\mathcal{O}}(1)$ rounds. This is the most efficient constant-rounds solution to date. The second protocol requires only $\\ensuremath{\\mathcal{O}} \\left( (\\log^2 \\ell)(\\kappa + \\operatorname{loglog} \\ell) \\right......We consider the problem of secure integer division: given two Paillier encryptions of ℓ-bit values n and d, determine an encryption of $\\lfloor \\frac{n}{d}\\rfloor$ without leaking any information about n or d. We propose two new protocols solving this problem. The first requires $\\ensuremath......)$ arithmetic operations in $\\ensuremath{\\mathcal{O}}(\\log^2 \\ell)$ rounds, where κ is a correctness parameter. Theoretically, this is the most efficient solution to date as all previous solutions have required Ω(ℓ) operations. Indeed, the fact that an o(ℓ) solution is possible at all is highly surprising....

Brief Measures of Anxiety in Non-Treatment-Seeking Youth with Autism Spectrum Disorder

Science.gov (United States)

Kerns, Connor Morrow; Maddox, Brenna B.; Kendall, Philip C.; Rump, Keiran; Berry, Leandra; Schultz, Robert T.; Souders, Margaret C.; Bennett, Amanda; Herrington, John; Miller, Judith

2015-01-01

This study investigated the accuracy of brief anxiety scales for non-treatment-seeking youth with autism spectrum disorder. In all, 54 youth (7-17?years; IQ: 67-158) with autism spectrum disorder and their parents completed (a) an expanded version of the Anxiety Disorders Interview Schedule--Child/Parent designed to capture typical and atypical…

Single-electron transport driven by surface acoustic waves: Moving quantum dots versus short barriers

DEFF Research Database (Denmark)

Utko, Pawel; Hansen, Jørn Bindslev; Lindelof, Poul Erik

2007-01-01

We have investigated the response of the acoustoelectric-current driven by a surface-acoustic wave through a quantum point contact in the closed-channel regime. Under proper conditions, the current develops plateaus at integer multiples of ef when the frequency f of the surface-acoustic wave...... or the gate voltage V-g of the point contact is varied. A pronounced 1.1 MHz beat period of the current indicates that the interference of the surface-acoustic wave with reflected waves matters. This is supported by the results obtained after a second independent beam of surface-acoustic wave was added......, traveling in opposite direction. We have found that two sub-intervals can be distinguished within the 1.1 MHz modulation period, where two different sets of plateaus dominate the acoustoelectric-current versus gate-voltage characteristics. In some cases, both types of quantized steps appeared simultaneously...

Physical Applications of a Simple Approximation of Bessel Functions of Integer Order

Science.gov (United States)

Barsan, V.; Cojocaru, S.

2007-01-01

Applications of a simple approximation of Bessel functions of integer order, in terms of trigonometric functions, are discussed for several examples from electromagnetism and optics. The method may be applied in the intermediate regime, bridging the "small values regime" and the "asymptotic" one, and covering, in this way, an area of great…

An improved exploratory search technique for pure integer linear programming problems

Science.gov (United States)

Fogle, F. R.

1990-01-01

The development is documented of a heuristic method for the solution of pure integer linear programming problems. The procedure draws its methodology from the ideas of Hooke and Jeeves type 1 and 2 exploratory searches, greedy procedures, and neighborhood searches. It uses an efficient rounding method to obtain its first feasible integer point from the optimal continuous solution obtained via the simplex method. Since this method is based entirely on simple addition or subtraction of one to each variable of a point in n-space and the subsequent comparison of candidate solutions to a given set of constraints, it facilitates significant complexity improvements over existing techniques. It also obtains the same optimal solution found by the branch-and-bound technique in 44 of 45 small to moderate size test problems. Two example problems are worked in detail to show the inner workings of the method. Furthermore, using an established weighted scheme for comparing computational effort involved in an algorithm, a comparison of this algorithm is made to the more established and rigorous branch-and-bound method. A computer implementation of the procedure, in PC compatible Pascal, is also presented and discussed.

Replication of a Modified Factor Structure for the Eating Disorder Examination-Questionnaire: Extension to Clinical Eating Disorder and Non-clinical Samples in Portugal.

Science.gov (United States)

Machado, Paulo P P; Grilo, Carlos M; Crosby, Ross D

2018-01-01

Psychometric investigations of the Eating Disorder Examination-Questionnaire (EDE-Q) have generally not supported the original scale structure. The present study tested an alternative brief factor structure in two large Portuguese samples: (1) a non-clinical sample of N = 4117 female students and (2) a treatment-seeking sample of N = 609 patients diagnosed with eating disorders. Confirmatory factor analysis revealed a poor fit for the original EDE-Q structure in both the non-clinical and the clinical samples but revealed a good fit for the alternative 7-item 3-factor structure (dietary restraint, shape/weight overvaluation and body dissatisfaction). Factor loadings were invariant across samples and across the different specific eating disorder diagnoses in the clinical sample. These confirmatory factor analysis findings, which replicate findings from studies with diverse predominately overweight/obese samples, supported a modified 7-item, 3-factor structure for the EDE-Q. The reliable findings across different non-clinical and clinical eating disorder groups provide confidence regarding the potential utility of this brief version. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

Comparison of disordered eating symptoms and emotion regulation difficulties between female college athletes and non-athletes.

Science.gov (United States)

Wollenberg, Gena; Shriver, Lenka H; Gates, Gail E

2015-08-01

The purpose of the study was to compare the prevalence of disordered eating between female college athletes and non-athletes and explore emotion regulation as a potential mediator of the link between participation in athletics and disordered eating symptoms. Data for this cross-sectional study came from 527 college students in a mid-western state of the USA in fall of 2013 (376 non-athletes and 151 athletes). Disordered eating symptoms and emotion regulation were assessed utilizing the Eating Attitudes Test and the Difficulties with Emotion Regulation Scale in a survey-based format. The prevalence of disordered eating was higher in non-athletes (16.5%, vs. 6.6%; X(2)=62.8; pathletes reported more signs and symptoms of disordered eating than athletes (pathletic-status on disordered eating via emotion regulation; however, this effect did not reach practical significance. Our findings show that female athletes in our sample were somewhat protected from disordered eating compared to non-athletes, but the mechanism of this relationship is unclear. A further in-depth examination of other factors, such as self-esteem and body satisfaction, that may have contributed to this finding is warranted utilizing a large sample of female college students and athletes representing a variety of sports. Copyright © 2015 Elsevier Ltd. All rights reserved.

TRACKING SIMULATIONS NEAR HALF-INTEGER RESONANCE AT PEP-II

International Nuclear Information System (INIS)

Nosochkov, Yuri

2003-01-01

Beam-beam simulations predict that PEP-II luminosity can be increased by operating the horizontal betatron tune near and above a half-integer resonance. However, effects of the resonance and its synchrotron sidebands significantly enhance betatron and chromatic perturbations which tend to reduce dynamic aperture. In the study, chromatic variation of horizontal tune near the resonance was minimized by optimizing local sextupoles in the Interaction Region. Dynamic aperture was calculated using tracking simulations in LEGO code. Dependence of dynamic aperture on the residual orbit, dispersion and β distortion after correction was investigated

Design of problem-specific evolutionary algorithm/mixed-integer programming hybrids: two-stage stochastic integer programming applied to chemical batch scheduling

Science.gov (United States)

Urselmann, Maren; Emmerich, Michael T. M.; Till, Jochen; Sand, Guido; Engell, Sebastian

2007-07-01

Engineering optimization often deals with large, mixed-integer search spaces with a rigid structure due to the presence of a large number of constraints. Metaheuristics, such as evolutionary algorithms (EAs), are frequently suggested as solution algorithms in such cases. In order to exploit the full potential of these algorithms, it is important to choose an adequate representation of the search space and to integrate expert-knowledge into the stochastic search operators, without adding unnecessary bias to the search. Moreover, hybridisation with mathematical programming techniques such as mixed-integer programming (MIP) based on a problem decomposition can be considered for improving algorithmic performance. In order to design problem-specific EAs it is desirable to have a set of design guidelines that specify properties of search operators and representations. Recently, a set of guidelines has been proposed that gives rise to so-called Metric-based EAs (MBEAs). Extended by the minimal moves mutation they allow for a generalization of EA with self-adaptive mutation strength in discrete search spaces. In this article, a problem-specific EA for process engineering task is designed, following the MBEA guidelines and minimal moves mutation. On the background of the application, the usefulness of the design framework is discussed, and further extensions and corrections proposed. As a case-study, a two-stage stochastic programming problem in chemical batch process scheduling is considered. The algorithm design problem can be viewed as the choice of a hierarchical decision structure, where on different layers of the decision process symmetries and similarities can be exploited for the design of minimal moves. After a discussion of the design approach and its instantiation for the case-study, the resulting problem-specific EA/MIP is compared to a straightforward application of a canonical EA/MIP and to a monolithic mathematical programming algorithm. In view of the

Expansion around half-integer values, binomial sums, and inverse binomial sums

International Nuclear Information System (INIS)

Weinzierl, Stefan

2004-01-01

I consider the expansion of transcendental functions in a small parameter around rational numbers. This includes in particular the expansion around half-integer values. I present algorithms which are suitable for an implementation within a symbolic computer algebra system. The method is an extension of the technique of nested sums. The algorithms allow in addition the evaluation of binomial sums, inverse binomial sums and generalizations thereof

A quadratic approximation-based algorithm for the solution of multiparametric mixed-integer nonlinear programming problems

KAUST Repository

Domí nguez, Luis F.; Pistikopoulos, Efstratios N.

2012-01-01

An algorithm for the solution of convex multiparametric mixed-integer nonlinear programming problems arising in process engineering problems under uncertainty is introduced. The proposed algorithm iterates between a multiparametric nonlinear

Point Locations of 849 Continuous Record Streamflow Gages Used to Estmate Annual and Average Values of Water-Budget Components Based on Hydrograph Separation and PRISM Precipitation in the Appalachian Plateaus Region, 1900-2011

Data.gov (United States)

Department of the Interior — As part of the U.S. Geological Survey’s Groundwater Resources Program study of the Appalachian Plateaus aquifers, estimates of annual water-budget components were...

Qualitative analysis of interviews of future non-affective psychotic disorder patients and non-psychiatric controls: preliminary results

Directory of Open Access Journals (Sweden)

Katya Rubinstein

2014-03-01

Conclusions: The findings of this unique historical-prospective qualitative analysis of interviews performed before the onset of psychosis, confirmed previous findings of premorbid abnormality of future non-affective psychosis patients. Using qualitative analysis enabled obtaining a more in-depth understanding of the real-life experience of the premorbid period among patients with non-affective psychotic disorders.

Enhanced index tracking modeling in portfolio optimization with mixed-integer programming z approach

Science.gov (United States)

Siew, Lam Weng; Jaaman, Saiful Hafizah Hj.; Ismail, Hamizun bin

2014-09-01

Enhanced index tracking is a popular form of portfolio management in stock market investment. Enhanced index tracking aims to construct an optimal portfolio to generate excess return over the return achieved by the stock market index without purchasing all of the stocks that make up the index. The objective of this paper is to construct an optimal portfolio using mixed-integer programming model which adopts regression approach in order to generate higher portfolio mean return than stock market index return. In this study, the data consists of 24 component stocks in Malaysia market index which is FTSE Bursa Malaysia Kuala Lumpur Composite Index from January 2010 until December 2012. The results of this study show that the optimal portfolio of mixed-integer programming model is able to generate higher mean return than FTSE Bursa Malaysia Kuala Lumpur Composite Index return with only selecting 30% out of the total stock market index components.

Estimating Most Productive Scale Size in Data Envelopment Analysis with Integer Value Data

Science.gov (United States)

Dwi Sari, Yunita; Angria S, Layla; Efendi, Syahril; Zarlis, Muhammad

2018-01-01

The most productive scale size (MPSS) is a measurement that states how resources should be organized and utilized to achieve optimal results. The most productive scale size (MPSS) can be used as a benchmark for the success of an industry or company in producing goods or services. To estimate the most productive scale size (MPSS), each decision making unit (DMU) should pay attention the level of input-output efficiency, by data envelopment analysis (DEA) method decision making unit (DMU) can identify units used as references that can help to find the cause and solution from inefficiencies can optimize productivity that main advantage in managerial applications. Therefore, data envelopment analysis (DEA) is chosen to estimating most productive scale size (MPSS) that will focus on the input of integer value data with the CCR model and the BCC model. The purpose of this research is to find the best solution for estimating most productive scale size (MPSS) with input of integer value data in data envelopment analysis (DEA) method.

Chromosome structures: reduction of certain problems with unequal gene content and gene paralogs to integer linear programming.

Science.gov (United States)

Lyubetsky, Vassily; Gershgorin, Roman; Gorbunov, Konstantin

2017-12-06

Chromosome structure is a very limited model of the genome including the information about its chromosomes such as their linear or circular organization, the order of genes on them, and the DNA strand encoding a gene. Gene lengths, nucleotide composition, and intergenic regions are ignored. Although highly incomplete, such structure can be used in many cases, e.g., to reconstruct phylogeny and evolutionary events, to identify gene synteny, regulatory elements and promoters (considering highly conserved elements), etc. Three problems are considered; all assume unequal gene content and the presence of gene paralogs. The distance problem is to determine the minimum number of operations required to transform one chromosome structure into another and the corresponding transformation itself including the identification of paralogs in two structures. We use the DCJ model which is one of the most studied combinatorial rearrangement models. Double-, sesqui-, and single-operations as well as deletion and insertion of a chromosome region are considered in the model; the single ones comprise cut and join. In the reconstruction problem, a phylogenetic tree with chromosome structures in the leaves is given. It is necessary to assign the structures to inner nodes of the tree to minimize the sum of distances between terminal structures of each edge and to identify the mutual paralogs in a fairly large set of structures. A linear algorithm is known for the distance problem without paralogs, while the presence of paralogs makes it NP-hard. If paralogs are allowed but the insertion and deletion operations are missing (and special constraints are imposed), the reduction of the distance problem to integer linear programming is known. Apparently, the reconstruction problem is NP-hard even in the absence of paralogs. The problem of contigs is to find the optimal arrangements for each given set of contigs, which also includes the mutual identification of paralogs. We proved that these

An improved contrast enhancement algorithm for infrared images based on adaptive double plateaus histogram equalization

Science.gov (United States)

Li, Shuo; Jin, Weiqi; Li, Li; Li, Yiyang

2018-05-01

Infrared thermal images can reflect the thermal-radiation distribution of a particular scene. However, the contrast of the infrared images is usually low. Hence, it is generally necessary to enhance the contrast of infrared images in advance to facilitate subsequent recognition and analysis. Based on the adaptive double plateaus histogram equalization, this paper presents an improved contrast enhancement algorithm for infrared thermal images. In the proposed algorithm, the normalized coefficient of variation of the histogram, which characterizes the level of contrast enhancement, is introduced as feedback information to adjust the upper and lower plateau thresholds. The experiments on actual infrared images show that compared to the three typical contrast-enhancement algorithms, the proposed algorithm has better scene adaptability and yields better contrast-enhancement results for infrared images with more dark areas or a higher dynamic range. Hence, it has high application value in contrast enhancement, dynamic range compression, and digital detail enhancement for infrared thermal images.

A computational non-commutative geometry program for disordered topological insulators

CERN Document Server

Prodan, Emil

2017-01-01

This work presents a computational program based on the principles of non-commutative geometry and showcases several applications to topological insulators. Noncommutative geometry has been originally proposed by Jean Bellissard as a theoretical framework for the investigation of homogeneous condensed matter systems. Recently, this approach has been successfully applied to topological insulators, where it facilitated many rigorous results concerning the stability of the topological invariants against disorder. In the first part of the book the notion of a homogeneous material is introduced and the class of disordered crystals defined together with the classification table, which conjectures all topological phases from this class. The manuscript continues with a discussion of electrons’ dynamics in disordered crystals and the theory of topological invariants in the presence of strong disorder is briefly reviewed. It is shown how all this can be captured in the language of noncommutative geometry using the co...

Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity.

Science.gov (United States)

Elli, Luca; Branchi, Federica; Tomba, Carolina; Villalta, Danilo; Norsa, Lorenzo; Ferretti, Francesca; Roncoroni, Leda; Bardella, Maria Teresa

2015-06-21

Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis.

Integer Programming Formulation of the Problem of Generating Milton Babbitt's All-partition Arrays

DEFF Research Database (Denmark)

Tanaka, Tsubasa; Bemman, Brian; Meredith, David

2016-01-01

Milton Babbitt (1916–2011) was a composer of twelve-tone serial music noted for creating the all-partition array. The problem of generating an all-partition array involves finding a rectangular array of pitch-class integers that can be partitioned into regions, each of which represents a distinct...

A mixed integer program to model spatial wildfire behavior and suppression placement decisions

Science.gov (United States)

Erin J. Belval; Yu Wei; Michael. Bevers

2015-01-01

Wildfire suppression combines multiple objectives and dynamic fire behavior to form a complex problem for decision makers. This paper presents a mixed integer program designed to explore integrating spatial fire behavior and suppression placement decisions into a mathematical programming framework. Fire behavior and suppression placement decisions are modeled using...

Equitably Distributing Quality of Marine Security Guards Using Integer Programming

Science.gov (United States)

2013-03-01

ARB BALMOD COM DoD DoS E HAF HQ 10 IP IQ LP MOS MCESG MSG MSGAT NLP NMC OSAB PCS PP&O Q RSO SAl SD SE SNCO T-ODP LIST OF...and Eurasia 2 Abu Dhabi, United Arab Emirates India and the Middle East 3 Bangkok, Thailand East Asia and Pacific 4 Fort Lauderdale, Florida South...integer, goal, and quadratic programming. LP models and nonlinear programming ( NLP ) models are very similar in model development for both maximizing

Statistical analysis of the limitation of half integer resonances on the available momentum acceptance of the High Energy Photon Source

Energy Technology Data Exchange (ETDEWEB)

Jiao, Yi, E-mail: jiaoyi@ihep.ac.cn; Duan, Zhe

2017-01-01

In a diffraction-limited storage ring, half integer resonances can have strong effects on the beam dynamics, associated with the large detuning terms from the strong focusing and strong sextupoles as required for an ultralow emittance. In this study, the limitation of half integer resonances on the available momentum acceptance (MA) was statistically analyzed based on one design of the High Energy Photon Source (HEPS). It was found that the probability of MA reduction due to crossing of half integer resonances is closely correlated with the level of beta beats at the nominal tunes, but independent of the error sources. The analysis indicated that for the presented HEPS lattice design, the rms amplitude of beta beats should be kept below 1.5% horizontally and 2.5% vertically to reach a small MA reduction probability of about 1%.

Depletion of superfluidity in a disordered non-equilibrium quantum condensate

Energy Technology Data Exchange (ETDEWEB)

Janot, Alexander; Rosenow, Bernd [Institut fuer Theoretische Physik, Universitaet Leipzig, 04009 Leipzig (Germany); Hyart, Timo [Institute of Physics, Leiden University, Niels Bohrweg 2, 2333 CA Leiden (Netherlands); Eastham, Paul [School of Physics, Trinity College, Dublin 2 (Ireland)

2013-07-01

Observations of quantum coherence in driven systems, e.g. polariton condensates, have strongly stimulated experimental as well as theoretical efforts during the last decade. We analyze the superfluid stiffness of a non-equilibrium quantum-condensate in a disordered environment taking gain and loss of particles into account. To this end a modified effective Gross-Pitaevskii equation is employed. We find that the disorder-driven depletion of superfluidity is strongly enhanced due to the gain-loss mechanism. It turns out that the condensate remains stiff at finite length scales only.

Applications and algorithms for mixed integer nonlinear programming

International Nuclear Information System (INIS)

Leyffer, Sven; Munson, Todd; Linderoth, Jeff; Luedtke, James; Miller, Andrew

2009-01-01

The mathematical modeling of systems often requires the use of both nonlinear and discrete components. Discrete decision variables model dichotomies, discontinuities, and general logical relationships. Nonlinear functions are required to accurately represent physical properties such as pressure, stress, temperature, and equilibrium. Problems involving both discrete variables and nonlinear constraint functions are known as mixed-integer nonlinear programs (MINLPs) and are among the most challenging computational optimization problems faced by researchers and practitioners. In this paper, we describe relevant scientific applications that are naturally modeled as MINLPs, we provide an overview of available algorithms and software, and we describe ongoing methodological advances for solving MINLPs. These algorithmic advances are making increasingly larger instances of this important family of problems tractable.

Half-integer ghost states and simple BRST quantization

International Nuclear Information System (INIS)

Marnelius, R.

1987-01-01

Quantum mechanical BRST systems are considered. As is well known an odd number of ghost operators has a representation with respect to the ghost number operator consisting of states with half-integer ghost numbers. Here it is shown that an eigenstate representation of the ghost operators requires a particular mixed Grassmann character of the states. It is also shown that such states always may be avoided provided only one starts from a lagrangian where the fundamental constraints are generated by Lagrange multipliers. In the latter case there also exists an anti-BRST charge. Some relevant properties of the different BRST approaches are displayed. The existence of inequivalent physical representations is demonstrated. (orig.)

Mixed-integer evolution strategies for parameter optimization and their applications to medical image analysis

NARCIS (Netherlands)

Li, Rui

2009-01-01

The target of this work is to extend the canonical Evolution Strategies (ES) from traditional real-valued parameter optimization domain to mixed-integer parameter optimization domain. This is necessary because there exist numerous practical optimization problems from industry in which the set of

Identifying optimal regional solid waste management strategies through an inexact integer programming model containing infinite objectives and constraints.

Science.gov (United States)

He, Li; Huang, Guo-He; Zeng, Guang-Ming; Lu, Hong-Wei

2009-01-01

The previous inexact mixed-integer linear programming (IMILP) method can only tackle problems with coefficients of the objective function and constraints being crisp intervals, while the existing inexact mixed-integer semi-infinite programming (IMISIP) method can only deal with single-objective programming problems as it merely allows the number of constraints to be infinite. This study proposes, an inexact mixed-integer bi-infinite programming (IMIBIP) method by incorporating the concept of functional intervals into the programming framework. Different from the existing methods, the IMIBIP can tackle the inexact programming problems that contain both infinite objectives and constraints. The developed method is applied to capacity planning of waste management systems under a variety of uncertainties. Four scenarios are considered for comparing the solutions of IMIBIP with those of IMILP. The results indicate that reasonable solutions can be generated by the IMIBIP method. Compared with IMILP, the system cost from IMIBIP would be relatively high since the fluctuating market factors are considered; however, the IMILP solutions are associated with a raised system reliability level and a reduced constraint violation risk level.

INTEG INSPEC, Accident Frequencies and Safety Analysis for Nuclear Power Plant

International Nuclear Information System (INIS)

Arnett, L.M.

1976-01-01

1 - Description of problem or function: These programs analyze the characteristics of a general model developed to represent the safety aspects of an operating nuclear reactor. These characteristics are the frequencies of incidents that are departures from the expected behavior of the reactor. Each incident is assumed to be preceded by a sequence of events starting at some initiating event. At each member in this sequence there may be functions such as safety circuits, and personnel operations that stop the sequence at that member. When mechanical devices fail they are assumed to remain inoperative until repaired. The model accounts for scheduled inspection and maintenance of all equipment in the system. 2 - Method of solution: In INTEG, the discontinuous density function is integrated by the trapezoidal rule from time equals zero to time equals t. INSPEC is based on the simulation of reactor operation as a Markov process. A vector of probabilities is successively multiplied by a transition matrix. 3 - Restrictions on the complexity of the problem: INSPEC is limited to subsystems with no more than 7 safety circuits. The transition matrix can be made up as desired so that any intercorrelations between failures of circuits can be accommodated. In INTEG, failure rates of safety circuits are restricted to independence

Non-equilibrium Green's functions method: Non-trivial and disordered leads

International Nuclear Information System (INIS)

He, Yu; Wang, Yu; Klimeck, Gerhard; Kubis, Tillmann

2014-01-01

The non-equilibrium Green's function algorithm requires contact self-energies to model charge injection and extraction. All existing approaches assume infinitely periodic leads attached to a possibly quite complex device. This contradicts today's realistic devices in which contacts are spatially inhomogeneous, chemically disordered, and impacting the overall device characteristics. This work extends the complex absorbing potentials method for arbitrary, ideal, or non-ideal leads in atomistic tight binding representation. The algorithm is demonstrated on a Si nanowire with periodic leads, a graphene nanoribbon with trumpet shape leads, and devices with leads of randomly alloyed Si 0.5 Ge 0.5 . It is found that alloy randomness in the leads can reduce the predicted ON-state current of Si 0.5 Ge 0.5 transistors by 45% compared to conventional lead methods

Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity

Science.gov (United States)

Elli, Luca; Branchi, Federica; Tomba, Carolina; Villalta, Danilo; Norsa, Lorenzo; Ferretti, Francesca; Roncoroni, Leda; Bardella, Maria Teresa

2015-01-01

Cereal crops and cereal consumption have had a vital role in Mankind’s history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient’s clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. PMID:26109797

Declarative and Non-declarative Memory Consolidation in Children with Sleep Disorder

OpenAIRE

Cs?bi, Eszter; Benedek, P?lma; Janacsek, Karolina; Zavecz, Zs?fia; Katona, G?bor; Nemeth, Dezso

2016-01-01

Healthy sleep is essential in children’s cognitive, behavioral, and emotional development. However, remarkably little is known about the influence of sleep disorders on different memory processes in childhood. Such data could give us a deeper insight into the effect of sleep on the developing brain and memory functions and how the relationship between sleep and memory changes from childhood to adulthood. In the present study we examined the effect of sleep disorder on declarative and non-decl...

Exact diagonalization study of domain structures in integer filling factor quantum Hall ferromagnets

Czech Academy of Sciences Publication Activity Database

Rezayi, E. H.; Jungwirth, Tomáš; MacDonald, A. H.; Haldane, F. D. M.

2003-01-01

Roč. 67, č. 20 (2003), s. 201305-1 - 201305-4 ISSN 0163-1829 R&D Projects: GA ČR GA202/01/0754 Institutional research plan: CEZ:AV0Z1010914 Keywords : domain structure * integer filling factor * quantum Hall ferromagnets Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.962, year: 2003

A new methodological development for solving linear bilevel integer programming problems in hybrid fuzzy environment

Directory of Open Access Journals (Sweden)

Animesh Biswas

2016-04-01

Full Text Available This paper deals with fuzzy goal programming approach to solve fuzzy linear bilevel integer programming problems with fuzzy probabilistic constraints following Pareto distribution and Frechet distribution. In the proposed approach a new chance constrained programming methodology is developed from the view point of managing those probabilistic constraints in a hybrid fuzzy environment. A method of defuzzification of fuzzy numbers using ?-cut has been adopted to reduce the problem into a linear bilevel integer programming problem. The individual optimal value of the objective of each DM is found in isolation to construct the fuzzy membership goals. Finally, fuzzy goal programming approach is used to achieve maximum degree of each of the membership goals by minimizing under deviational variables in the decision making environment. To demonstrate the efficiency of the proposed approach, a numerical example is provided.

Influence of disorder on superconductivity in non-magnetic rare ...

Indian Academy of Sciences (India)

Influence of disorder on superconductivity in non-magnetic rare-earth nickel borocarbides. G FUCHS1,∗. , K-H M ¨ULLER1, J FREUDENBERGER1, K NENKOV1,. S-L DRECHSLER1, S V SHULGA1, D LIPP2, A GLADUN2,. T CICHOREK3 and P GEGENWART3. 1Institut für Festkörper- und Werkstofforschung, D-01171 ...

Numerical study of two dimensional disordered systems in an external magnetic field

International Nuclear Information System (INIS)

Jana, Debnarayan

2000-01-01

We study here 2d tight-binding disordered model in an external magnetic field. By numerically diagonalizing the Hamiltonian, we characterize the eigenstates by Generalized Inverse Participation Ratio (GIPR). The properties of the eigenstates have been studied in case of random flux model as well as with the strength of disorder. Simple theoretical arguments are given in support of the numerical observation. Finally, we have also studied the multifractality of the eigenstates. All these study may shed light on the eigenstates in the center of the band in case of Integer Quantum Hall Effect (IQHE). (author)

Non-equilibrium dynamics of disordered systems: understanding the broad continuum of relevant time scales via a strong-disorder RG in configuration space

International Nuclear Information System (INIS)

Monthus, Cecile; Garel, Thomas

2008-01-01

We show that an appropriate description of the non-equilibrium dynamics of disordered systems is obtained through a strong disorder renormalization procedure in configuration space that we define for any master equation with transitions rates W(C→C') between configurations. The idea is to eliminate iteratively the configuration with the highest exit rate W out (C)+Σ C' W(C→C') to obtain renormalized transition rates between the remaining configurations. The multiplicative structure of the new generated transition rates suggests that for a very broad class of disordered systems, the distribution of renormalized exit barriers defined as B out (C)≡-ln W out (C) will become broader and broader upon iteration, so that the strong disorder renormalization procedure should become asymptotically exact at large time scales. We have checked numerically this scenario for the non-equilibrium dynamics of a directed polymer in a two-dimensional random medium

Non-equilibrium Green's functions method: Non-trivial and disordered leads

Energy Technology Data Exchange (ETDEWEB)

He, Yu, E-mail: heyuyhe@gmail.com; Wang, Yu; Klimeck, Gerhard; Kubis, Tillmann [Network for Computational Nanotechnology, Purdue University, West Lafayette, Indiana 47907 (United States)

2014-11-24

The non-equilibrium Green's function algorithm requires contact self-energies to model charge injection and extraction. All existing approaches assume infinitely periodic leads attached to a possibly quite complex device. This contradicts today's realistic devices in which contacts are spatially inhomogeneous, chemically disordered, and impacting the overall device characteristics. This work extends the complex absorbing potentials method for arbitrary, ideal, or non-ideal leads in atomistic tight binding representation. The algorithm is demonstrated on a Si nanowire with periodic leads, a graphene nanoribbon with trumpet shape leads, and devices with leads of randomly alloyed Si{sub 0.5}Ge{sub 0.5}. It is found that alloy randomness in the leads can reduce the predicted ON-state current of Si{sub 0.5}Ge{sub 0.5} transistors by 45% compared to conventional lead methods.

Deviation of the Variances of Classical Estimators and Negative Integer Moment Estimator from Minimum Variance Bound with Reference to Maxwell Distribution

Directory of Open Access Journals (Sweden)

G. R. Pasha

2006-07-01

Full Text Available In this paper, we present that how much the variances of the classical estimators, namely, maximum likelihood estimator and moment estimator deviate from the minimum variance bound while estimating for the Maxwell distribution. We also sketch this difference for the negative integer moment estimator. We note the poor performance of the negative integer moment estimator in the said consideration while maximum likelihood estimator attains minimum variance bound and becomes an attractive choice.

A Finer Classification of the Unit Sum Number of the Ring of Integers ...

Indian Academy of Sciences (India)

Here we introduce a finer classification for the unit sum number of a ring and in this new classification we completely determine the unit sum number of the ring of integers of a quadratic field. Further we obtain some results on cubic complex fields which one can decide whether the unit sum number is or ∞. Then we ...

Equilibrium prices supported by dual price functions in markets with non-convexities

International Nuclear Information System (INIS)

Bjoerndal, Mette; Joernsten, Kurt

2004-06-01

The issue of finding market clearing prices in markets with non-convexities has had a renewed interest due to the deregulation of the electricity sector. In the day-ahead electricity market, equilibrium prices are calculated based on bids from generators and consumers. In most of the existing markets, several generation technologies are present, some of which have considerable non-convexities, such as capacity limitations and large start up costs. In this paper we present equilibrium prices composed of a commodity price and an uplift charge. The prices are based on the generation of a separating valid inequality that supports the optimal resource allocation. In the case when the sub-problem generated as the integer variables are held fixed to their optimal values possess the integrality property, the generated prices are also supported by non-linear price-functions that are the basis for integer programming duality. (Author)

Distribution Locational Marginal Pricing for Optimal Electric Vehicle Charging through Chance Constrained Mixed-Integer Programming

DEFF Research Database (Denmark)

Liu, Zhaoxi; Wu, Qiuwei; Oren, Shmuel S.

2017-01-01

This paper presents a distribution locational marginal pricing (DLMP) method through chance constrained mixed-integer programming designed to alleviate the possible congestion in the future distribution network with high penetration of electric vehicles (EVs). In order to represent the stochastic...

Robust integer and fractional helical modes in the quantum Hall effect

Science.gov (United States)

Ronen, Yuval; Cohen, Yonatan; Banitt, Daniel; Heiblum, Moty; Umansky, Vladimir

2018-04-01

Electronic systems harboring one-dimensional helical modes, where spin and momentum are locked, have lately become an important field of their own. When coupled to a conventional superconductor, such systems are expected to manifest topological superconductivity; a unique phase hosting exotic Majorana zero modes. Even more interesting are fractional helical modes, yet to be observed, which open the route for realizing generalized parafermions. Possessing non-Abelian exchange statistics, these quasiparticles may serve as building blocks in topological quantum computing. Here, we present a new approach to form protected one-dimensional helical edge modes in the quantum Hall regime. The novel platform is based on a carefully designed double-quantum-well structure in a GaAs-based system hosting two electronic sub-bands; each tuned to the quantum Hall effect regime. By electrostatic gating of different areas of the structure, counter-propagating integer, as well as fractional, edge modes with opposite spins are formed. We demonstrate that, due to spin protection, these helical modes remain ballistic over large distances. In addition to the formation of helical modes, this platform can serve as a rich playground for artificial induction of compounded fractional edge modes, and for construction of edge-mode-based interferometers.

Mixed-Integer-Linear-Programming-Based Energy Management System for Hybrid PV-Wind-Battery Microgrids

DEFF Research Database (Denmark)

Hernández, Adriana Carolina Luna; Aldana, Nelson Leonardo Diaz; Graells, Moises

2017-01-01

-side strategy, defined as a general mixed-integer linear programming by taking into account two stages for proper charging of the storage units. This model is considered as a deterministic problem that aims to minimize operating costs and promote self-consumption based on 24-hour ahead forecast data...

Affective disorders and functional (non-epileptic) seizures in persons with epilepsy.

Science.gov (United States)

Johnson, Keith A; Macfarlane, Matthew D; Looi, Jeffrey Cl

2016-12-01

This paper aims to describe the prevalence, assessment and management of affective disorders as well as functional (non-epileptic) seizures in people with epilepsy. This paper comprises a selective review of the literature of the common affective manifestations of epilepsy. Affective disorders are the most common psychiatric comorbidity seen in people with epilepsy and assessment and management parallels that of the general population. Additionally, people with epilepsy may experience higher rates of mood instability, irritability and euphoria, classified together as a group, interictal dysphoric disorder and resembling an unstable bipolar Type II disorder. Functional seizures present unique challenges in terms of identification of the disorder and a lack of specific management. Given their high prevalence, it is important to be able to recognise affective disorders in people with epilepsy. Management principles parallel those in the general population with specific caution exercised regarding the potential interactions between antidepressant medications and antiepileptic drugs. Functional seizures are more complex and require a coordinated approach involving neurologists, psychiatrists, general practitioners, nursing and allied health. There is very limited evidence to guide psychological and behavioural interventions for neurotic disorders in epilepsy and much more research is needed. © The Royal Australian and New Zealand College of Psychiatrists 2016.

COMPUTING VERTICES OF INTEGER PARTITION POLYTOPES

Directory of Open Access Journals (Sweden)

A. S. Vroublevski

2015-01-01

Full Text Available The paper describes a method of generating vertices of the polytopes of integer partitions that was used by the authors to calculate all vertices and support vertices of the partition polytopes for all n ≤ 105 and all knapsack partitions of n ≤ 165. The method avoids generating all partitions of n. The vertices are determined with the help of sufficient and necessary conditions; in the hard cases, the well-known program Polymake is used. Some computational aspects are exposed in more detail. These are the algorithm for checking the criterion that characterizes partitions that are convex combinations of two other partitions; the way of using two combinatorial operations that transform the known vertices to the new ones; and employing the Polymake to recognize a limited number (for small n of partitions that need three or more other partitions for being convexly expressed. We discuss the computational results on the numbers of vertices and support vertices of the partition polytopes and some appealing problems these results give rise to.

Gait disorder rehabilitation using vision and non-vision based sensors: A systematic review

Directory of Open Access Journals (Sweden)

Asraf Ali

2012-08-01

Full Text Available Even though the amount of rehabilitation guidelines has never been greater, uncertainty continues to arise regarding the efficiency and effectiveness of the rehabilitation of gait disorders. This question has been hindered by the lack of information on accurate measurements of gait disorders. Thus, this article reviews the rehabilitation systems for gait disorder using vision and non-vision sensor technologies, as well as the combination of these. All papers published in the English language between 1990 and June, 2012 that had the phrases “gait disorder” “rehabilitation”, “vision sensor”, or “non vision sensor” in the title, abstract, or keywords were identified from the SpringerLink, ELSEVIER, PubMed, and IEEE databases. Some synonyms of these phrases and the logical words “and” “or” and “not” were also used in the article searching procedure. Out of the 91 published articles found, this review identified 84 articles that described the rehabilitation of gait disorders using different types of sensor technologies. This literature set presented strong evidence for the development of rehabilitation systems using a markerless vision-based sensor technology. We therefore believe that the information contained in this review paper will assist the progress of the development of rehabilitation systems for human gait disorders.

Prevalence of Internet Gaming Disorder among Korean Adolescents and Associations with Non-psychotic Psychological Symptoms, and Physical Aggression.

Science.gov (United States)

Yu, Hongsik; Cho, Jaehee

2016-11-01

We examined the prevalence rates of Internet gaming disorder among South Korean middle school students, the dominant symptoms of Internet gaming disorder, and the interrelationships between such disorder and non-psychotic psychological symptoms (ie, anxiety, depression, and impulsiveness) and with physical aggression. Data were collected from a national sample of 2024 students (70.3% gamers; 50.6% boys). Gaming disorder and prevalent symptoms were measured by the 9 diagnostic criteria proposed in DSM-5. Our results showed 5.9% of the sample (boys 10.4%, girls 1.2%) was classified as adolescents with gaming disorder. Meanwhile, 8% (boys 14.2%, girls 5.9%) of the sample was found to be at high risk of gaming disorder. The prevalent symptoms were mood modification, behavioral salience, conflict, withdrawal, and relapse, in that order. A total of 9.2%, 15.1%, and 10.9% of the adolescents with gaming disorder had non-psychotic psychological anxiety, depression, and impulsiveness symptoms, respectively. Nearly 11% of students with Internet gaming disorder had 2 non-psychotic psychological symptoms or more. These results provide supportive empirical evidence that Internet gaming disorder can lead to severe distress and that it can be associated with comorbid symptoms that are relevant to development or continuance of the gaming disorder.

Suicidality in non-treatment seeking young adults with subsyndromal gambling disorder.

Science.gov (United States)

Grant, Jon E; Derbyshire, Katherine; Leppink, Eric; Chamberlain, Samuel R

2014-12-01

Gambling Disorder is associated with elevated rates of suicidal thoughts and acts. However, virtually nothing is known about suicidality in people with subsyndromal forms of gambling disorder. A total of 174 non-treatment seeking subjects were recruited for a study of impulsivity and met criteria for a subsyndromal form of DSM-5 gambling disorder (31.0 % females; mean age = 21.7 ± 3.61 years). Subjects were categorized as being 'at risk of suicide' or 'no suicide risk' based on the Mini-International Neuropsychiatric Interview (MINI). Those with and without suicidality were compared on clinical and cognitive measures. 32 (18.4 %) met MINI criteria for suicidality. Suicidality was significantly associated with mood and anxiety disorders, greater rates of nicotine consumption, and relative impairments in decision-making and cognitive flexibility. These findings suggest that decision-making impairments may be implicated in the development of both gambling problems and suicidality. Future work should address causality, neural correlates, and tailored suicide prevention strategies for people with, or at risk for, disordered forms of gambling.

VLSI Architectures for the Multiplication of Integers Modulo a Fermat Number

Science.gov (United States)

Chang, J. J.; Truong, T. K.; Reed, I. S.; Hsu, I. S.

1984-01-01

Multiplication is central in the implementation of Fermat number transforms and other residue number algorithms. There is need for a good multiplication algorithm that can be realized easily on a very large scale integration (VLSI) chip. The Leibowitz multiplier is modified to realize multiplication in the ring of integers modulo a Fermat number. This new algorithm requires only a sequence of cyclic shifts and additions. The designs developed for this new multiplier are regular, simple, expandable, and, therefore, suitable for VLSI implementation.

Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux.

Science.gov (United States)

Herdman, Christine; Marzio, Dina Halegoua-De; Shah, Paurush; Denuna-Rivera, Susie; Doghramji, Karl; Cohen, Sidney; Dimarino, Anthony J

2013-01-01

Nocturnal acid reflux is associated with symptomatic and asymptomatic sleep arousals, leading to fragmented sleep. The frequency and influence of acid reflux in patients with various forms of insomnia has not been reported. The aim of this study was to quantify nocturnal acid and nonacid reflux in patients with primary sleep disorders as previously diagnosed by polysomnography. THIRTY ONE SUBJECTS WERE STUDIED: (A) 9 subjects with a polysomnographically diagnosed sleep disorder (1 with restless legs syndrome, 4 with narcolepsy, 4 with periodic limb movement disorder); (B) 12 subjects with primary insomnia (PI) and unrevealing polysomnography; and (C) 10 controls without disturbed sleep. All subjects underwent a physical examination and 24 h transnasal pH and impedance monitoring to detect acid and non-acid reflux. The 21 subjects with fragmented sleep due to a primary sleep disorder had significantly more recumbent acid exposure (>1.2% of time) as compared with control subjects (33% versus 0%). When fragmented sleep subjects were divided into two groups, 17% of PI subjects and 55% of subjects with a diagnosed sleep disorder had significant recumbent acid exposure (P=0.009). Likewise, the median recumbent nonacid events were increased in the sleep disordered group (P=0.011). This study indicates that patients with primary sleep disorders have prominent nocturnal acid reflux without symptoms of daytime acid reflux. Acid reflux is most prominent in patients with polysomnographic findings of disturbed sleep as compared to patients with PI; while non acid reflux is increased minimally in these patients.

Stability and non-standard finite difference method of the generalized Chua's circuit

KAUST Repository

Radwan, Ahmed G.

2011-08-01

In this paper, we develop a framework to obtain approximate numerical solutions of the fractional-order Chua\\'s circuit with Memristor using a non-standard finite difference method. Chaotic response is obtained with fractional-order elements as well as integer-order elements. Stability analysis and the condition of oscillation for the integer-order system are discussed. In addition, the stability analyses for different fractional-order cases are investigated showing a great sensitivity to small order changes indicating the poles\\' locations inside the physical s-plane. The GrnwaldLetnikov method is used to approximate the fractional derivatives. Numerical results are presented graphically and reveal that the non-standard finite difference scheme is an effective and convenient method to solve fractional-order chaotic systems, and to validate their stability. © 2011 Elsevier Ltd. All rights reserved.

Learning Bayesian network structure: towards the essential graph by integer linear programming tools

Czech Academy of Sciences Publication Activity Database

Studený, Milan; Haws, D.

2014-01-01

Roč. 55, č. 4 (2014), s. 1043-1071 ISSN 0888-613X R&D Projects: GA ČR GA13-20012S Institutional support: RVO:67985556 Keywords : learning Bayesian network structure * integer linear programming * characteristic imset * essential graph Subject RIV: BA - General Mathematics Impact factor: 2.451, year: 2014 http://library.utia.cas.cz/separaty/2014/MTR/studeny-0427002.pdf

A Mixed Integer Efficient Global Optimization Framework: Applied to the Simultaneous Aircraft Design, Airline Allocation and Revenue Management Problem

Science.gov (United States)

Roy, Satadru

Traditional approaches to design and optimize a new system, often, use a system-centric objective and do not take into consideration how the operator will use this new system alongside of other existing systems. This "hand-off" between the design of the new system and how the new system operates alongside other systems might lead to a sub-optimal performance with respect to the operator-level objective. In other words, the system that is optimal for its system-level objective might not be best for the system-of-systems level objective of the operator. Among the few available references that describe attempts to address this hand-off, most follow an MDO-motivated subspace decomposition approach of first designing a very good system and then provide this system to the operator who decides the best way to use this new system along with the existing systems. The motivating example in this dissertation presents one such similar problem that includes aircraft design, airline operations and revenue management "subspaces". The research here develops an approach that could simultaneously solve these subspaces posed as a monolithic optimization problem. The monolithic approach makes the problem a Mixed Integer/Discrete Non-Linear Programming (MINLP/MDNLP) problem, which are extremely difficult to solve. The presence of expensive, sophisticated engineering analyses further aggravate the problem. To tackle this challenge problem, the work here presents a new optimization framework that simultaneously solves the subspaces to capture the "synergism" in the problem that the previous decomposition approaches may not have exploited, addresses mixed-integer/discrete type design variables in an efficient manner, and accounts for computationally expensive analysis tools. The framework combines concepts from efficient global optimization, Kriging partial least squares, and gradient-based optimization. This approach then demonstrates its ability to solve an 11 route airline network

Globular and disordered-the non-identical twins in protein-protein interactions

DEFF Research Database (Denmark)

Teilum, Kaare; Olsen, Johan Gotthardt; Kragelund, Birthe Brandt

2015-01-01

as a strong determinant for their function. This has fostered the notion that IDP's bind with low affinity but high specificity. Here we have analyzed available detailed thermodynamic data for protein-protein interactions to put to the test if the thermodynamic profiles of IDP interactions differ from those...... of other protein-protein interactions. We find that ordered proteins and the disordered ones act as non-identical twins operating by similar principles but where the disordered proteins complexes are on average less stable by 2.5 kcal mol(-1)....

Consciousness in non-epileptic attack disorder.

Science.gov (United States)

Reuber, Markus; Kurthen, M

2011-01-01

Non-epileptic attack disorder (NEAD) is one of the most important differential diagnoses of epilepsy. Impairment of consciousness is the key feature of non-epileptic attacks (NEAs). The first half of this review summarises the clinical research literature featuring observations relating to consciousness in NEAD. The second half places this evidence in the wider context of the recent discourse on consciousness in neuroscience and the philosophy of mind. We argue that studies of consciousness should not only distinguish between the 'level' and `content' of consciousness but also between 'phenomenal consciousness' (consciousness of states it somehow "feels to be like") and 'access consciousness' (having certain 'higher' cognitive processes at one's disposal). The existing evidence shows that there is a great intra- and interindividual variability of NEA experience. However, in most NEAs phenomenal experience - and, as a precondition for that experience, vigilance or wakefulness - is reduced to a lesser degree than in those epileptic seizures involving impairment of consciousness. In fact, complete loss of "consciousness" is the exception rather than the rule in NEAs. Patients, as well as external observers, may have a tendency to overestimate impairments of consciousness during the seizures.

STUDY OF SOLUTION REPRESENTATION LANGUAGE INFLUENCE ON EFFICIENCY OF INTEGER SEQUENCES PREDICTION

Directory of Open Access Journals (Sweden)

A. S. Potapov

2015-01-01

Full Text Available Methods based on genetic programming for the problem solution of integer sequences extrapolation are the subjects for study in the paper. In order to check the hypothesis about the influence of language expression of program representation on the prediction effectiveness, the genetic programming method based on several limited languages for recurrent sequences has been developed. On the single sequence sample the implemented method with the use of more complete language has shown results, significantly better than the results of one of the current methods represented in literature based on artificial neural networks. Analysis of experimental comparison results for the realized method with the usage of different languages has shown that language extension increases the difficulty of consistent patterns search in languages, available for prediction in a simpler language though it makes new sequence classes accessible for prediction. This effect can be reduced but not eliminated completely at language extension by the constructions, which make solutions more compact. Carried out researches have drawn to the conclusion that alone the choice of an adequate language for solution representation is not enough for the full problem solution of integer sequences prediction (and, all the more, universal prediction problem. However, practically applied methods can be received by the usage of genetic programming.

Developing optimal nurses work schedule using integer programming

Science.gov (United States)

Shahidin, Ainon Mardhiyah; Said, Mohd Syazwan Md; Said, Noor Hizwan Mohamad; Sazali, Noor Izatie Amaliena

2017-08-01

Time management is the art of arranging, organizing and scheduling one's time for the purpose of generating more effective work and productivity. Scheduling is the process of deciding how to commit resources between varieties of possible tasks. Thus, it is crucial for every organization to have a good work schedule for their staffs. The job of Ward nurses at hospitals runs for 24 hours every day. Therefore, nurses will be working using shift scheduling. This study is aimed to solve the nurse scheduling problem at an emergency ward of a private hospital. A 7-day work schedule for 7 consecutive weeks satisfying all the constraints set by the hospital will be developed using Integer Programming. The work schedule for the nurses obtained gives an optimal solution where all the constraints are being satisfied successfully.

Parallel integer sorting with medium and fine-scale parallelism

Science.gov (United States)

Dagum, Leonardo

1993-01-01

Two new parallel integer sorting algorithms, queue-sort and barrel-sort, are presented and analyzed in detail. These algorithms do not have optimal parallel complexity, yet they show very good performance in practice. Queue-sort designed for fine-scale parallel architectures which allow the queueing of multiple messages to the same destination. Barrel-sort is designed for medium-scale parallel architectures with a high message passing overhead. The performance results from the implementation of queue-sort on a Connection Machine CM-2 and barrel-sort on a 128 processor iPSC/860 are given. The two implementations are found to be comparable in performance but not as good as a fully vectorized bucket sort on the Cray YMP.

Metabolic syndrome in patients with bipolar disorder: comparison with major depressive disorder and non-psychiatric controls.

Science.gov (United States)

Silarova, Barbora; Giltay, Erik J; Van Reedt Dortland, Arianne; Van Rossum, Elisabeth F C; Hoencamp, Erik; Penninx, Brenda W J H; Spijker, Annet T

2015-04-01

We aimed to investigate the prevalence of the metabolic syndrome (MetS) and its individual components in subjects with bipolar disorder (BD) compared to those with major depressive disorder (MDD) and non-psychiatric controls. We examined 2431 participants (mean age 44.3±13.0, 66.1% female), of whom 241 had BD; 1648 had MDD; and 542 were non-psychiatric controls. The MetS was ascertained according to NCEP ATP III criteria. Multivariable analyses were adjusted for age, sex, ethnicity, level of education, smoking status and severity of depressive symptoms, and in the case of BD subjects, also for psychotropic medication use. Subjects with BD had a significantly higher prevalence of MetS when compared to subjects with MDD and non-psychiatric controls (28.4% vs. 20.2% and 16.5%, respectively, pdifferences between BD subjects with controls could partly be ascribed to a higher mean waist circumference (91.0 cm vs. 88.8, respectively, p=0.03). In stratified analysis, the differences in the prevalence of MetS between patients with BD and MDD were found in symptomatic but not in asymptomatic cases. This study confirms a higher prevalence of MetS in patients with BD compared to both MDD patients and controls. Specifically at risk are patients with a higher depression score and abdominal obesity. Copyright © 2015 Elsevier Inc. All rights reserved.

The Comparision of Social Anxiety Disorder and Shyness in Addicted and Non-Addicted Men

Directory of Open Access Journals (Sweden)

Anari

2011-05-01

Full Text Available Introduction: The aim of this study was to compare social anxiety disorder and shyness in addicted and non-addicted men. Method: The method of this study was causal-comparative research and the sampling done by purposive sampling. However, 30 men who were addicted to opium and were referred for the first time to Arak Behzisti self report center were selected. Then, 30 paired samples of non-addicted men who had not any addiction history in their life selected as a comparison group and Henderson/Zimbardo Shyness Questionnaire (2001 and Liebowitz Social Anxiety Scale (1981 were administered in both groups. In SPSS software data was analyzed by running of independent samples t test. Results: the results showed that addicted men had reported higher scores in shyness and social phobia disorder in comparison to non-addicted men. Conclusion: With consideration of results it can be concluded that people with shyness and social anxiety disorder, use opium to reduce social anxiety and avoidance. Clinical implications for the prevention and treatment of substance abuse should be considered.

Radiotherapy for non-malignant disorders: state of the art and update of the evidence-based practice guidelines

Science.gov (United States)

Micke, O; Muecke, R

2015-01-01

Every year in Germany about 50,000 patients are referred and treated by radiotherapy (RT) for “non-malignant disorders”. This highly successful treatment is applied only for specific indications such as preservation or recovery of the quality of life by means of pain reduction or resolution and/or an improvement of formerly impaired physical body function owing to specific disease-related symptoms. Since 1995, German radiation oncologists have treated non-malignant disorders according to national consensus guidelines; these guidelines were updated and further developed over 3 years by implementation of a systematic consensus process to achieve national upgraded and accepted S2e clinical practice guidelines. Throughout this process, international standards of evaluation were implemented. This review summarizes most of the generally accepted indications for the application of RT for non-malignant diseases and presents the special treatment concepts. The following disease groups are addressed: painful degenerative skeletal disorders, hyperproliferative disorders and symptomatic functional disorders. These state of the art guidelines may serve as a platform for daily clinical work; they provide a new starting point for quality assessment, future clinical research, including the design of prospective clinical trials, and outcome research in the underrepresented and less appreciated field of RT for non-malignant disorders. PMID:25955230

A Mixed Integer Linear Programming Model for the North Atlantic Aircraft Trajectory Planning

OpenAIRE

Sbihi , Mohammed; Rodionova , Olga; Delahaye , Daniel; Mongeau , Marcel

2015-01-01

International audience; This paper discusses the trajectory planning problem for ights in the North Atlantic oceanic airspace (NAT). We develop a mathematical optimization framework in view of better utilizing available capacity by re-routing aircraft. The model is constructed by discretizing the problem parameters. A Mixed integer linear program (MILP) is proposed. Based on the MILP a heuristic to solve real-size instances is also introduced

Levitation and percolation in quantum Hall systems with correlated disorder

OpenAIRE

Song, Hui; Maruyama, Isao; Hatsugai, Yasuhiro

2007-01-01

We investigate the integer quantum Hall system in a two dimensional lattice model with spatially correlated disorder by using the efficient method to calculate the Chern number proposed by Fukui et al. [J. Phys. Soc. Jpn. 74, 1674 (2005)]. Distribution of charge density indicates that the extended states at the center of each Landau band have percolating current paths, which are topologically equivalent to the edge states that exist in a system with boundaries. As increasing the strength of d...

Changes in Pacific Absolute Plate Motion and Formation of Oceanic Flood Basalt Plateaus

Science.gov (United States)

Kroenke, L. W.; Wessel, P.

2006-12-01

The origin of the large oceanic flood basalt plateaus that are prominent features of the central western Pacific Basin remains unclear. Major changes in Pacific Absolute Plate Motion (APM) have been identified as occurring at 145, 125, 96, and 47 Ma. Formation of the Shatsky Rise (~145 Ma), the Ontong Java Plateau (122+ Ma), the Southern Hess Rise (95±5 Ma), and the Louisiade Plateau (~48 Ma) appear to coincide with these changes. A smaller, but still prominent change in Pacific APM also occurred at 110 Ma when the Northern Hess Rise formed. Although these concurrent events may simply be chance occurrences, initiation of plate tectonic reorganizations upon arrival of mantle plume heads also was proposed by Ratcliff et al. (1998), who suggested that the mantle plume head delivery of hot material to produce flood basalts also had the potential to trigger reorganizations of plate motions. It should be noted, however, that Pacific Rim subduction zone development also coincides with these APM changes, and that the actual cause and effect of each change in APM has yet to be clearly established. Here we present a modified Pacific APM model that uses several older seamount chains (Musicians, Ratak-Gilbert-Ellice, the Wake trails, and the Liliuokalani trails) to constrain the oldest Pacific plate motion using the hybrid technique of Wessel et al (2006).

Spherical Bessel functions jsub(n) and ysub(n) of integer order and real argument

International Nuclear Information System (INIS)

Ardill, R.W.B.; Moriarty, K.J.M.

1978-01-01

The spherical Bessel function appears in a variety of physical applications, and especially in phase shift analysis. The package SPHBES contains a subroutine to calculate jsub(n)(x) and ysub(n)(x) for any integer order n and real argument x. The functions jsub(n)(x) and ysub(n)(x) are produced simultaneously and efficiently. (Auth.)

Scheduling of head-dependent cascaded hydro systems: Mixed-integer quadratic programming approach

International Nuclear Information System (INIS)

Catalao, J.P.S.; Pousinho, H.M.I.; Mendes, V.M.F.

2010-01-01

This paper is on the problem of short-term hydro scheduling, particularly concerning head-dependent cascaded hydro systems. We propose a novel mixed-integer quadratic programming approach, considering not only head-dependency, but also discontinuous operating regions and discharge ramping constraints. Thus, an enhanced short-term hydro scheduling is provided due to the more realistic modeling presented in this paper. Numerical results from two case studies, based on Portuguese cascaded hydro systems, illustrate the proficiency of the proposed approach.

Modeling an integrated hospital management planning problem using integer optimization approach

Science.gov (United States)

Sitepu, Suryati; Mawengkang, Herman; Irvan

2017-09-01

Hospital is a very important institution to provide health care for people. It is not surprising that nowadays the people’s demands for hospital is increasing. However, due to the rising cost of healthcare services, hospitals need to consider efficiencies in order to overcome these two problems. This paper deals with an integrated strategy of staff capacity management and bed allocation planning to tackle these problems. Mathematically, the strategy can be modeled as an integer linear programming problem. We solve the model using a direct neighborhood search approach, based on the notion of superbasic variables.

A Mathematical Model for Scheduling a Batch Processing Machine with Multiple Incompatible Job Families, Non-identical Job dimensions, Non-identical Job sizes, Non-agreeable release times and due dates

International Nuclear Information System (INIS)

Ramasubramaniam, M; Mathirajan, M

2013-01-01

The paper addresses the problem scheduling a batch processing machine with multiple incompatible job families, non-identical job dimensions, non-identical job sizes and non-agreeable release dates to minimize makespan. The research problem is solved by proposing a mixed integer programming model that appropriately takes into account the parameters considered in the problem. The proposed is validated using a numerical example. The experiment conducted show that the model can pose significant difficulties in solving the large scale instances. The paper concludes by giving the scope for future work and some alternative approaches one can use for solving these class of problems.

NON-INVASIVE DIAGNOSTICS OF NON-TUMOR DISORDERS WITH OPTICAL COHERENCE TOMOGRAPHY

Directory of Open Access Journals (Sweden)

A. E. Meller

2016-01-01

tubes with features typical for healthy and inflammatory states. Presence of heterogeneity in the structure of an OCT image indicated heterogeneity in the muscle layer of the fallopian tube, which allowed for a conclusion on chronic salpingitis. With OCT hysteroscopy we demonstrated the ability of OCT to visualize pathomorphologic features of chronic endometritis. The diagnostic data obtained by OCT-rhinoscopy allowed to draw preliminary conclusions on the OCT ability to detect specific features of various types of chronic rhinitis. Numerical processing of diagnostic OCT images resulted in their higher objectivity and an improvement of diagnostic accuracy of the technique. Conclusion: OCT is able to detect morphological changes induced by a  chronic inflammatory process. OCT criteria were shown to be universal for various organs. We demonstrated the possibility of non-invasive diagnostics of pathomorphologic forms of disease, showed some challenges in the development of OCT for diagnostics of non-tumor disorders and ways to overcome them are proposed, in particular, the use of image numerical processing. Further studies seem to be justified.

A motion-based integer ambiguity resolution method for attitude determination using the global positioning system (GPS)

International Nuclear Information System (INIS)

Wang, Bo; Deng, Zhihong; Wang, Shunting; Fu, Mengyin

2010-01-01

Loss of the satellite signal and noise disturbance will cause cycle slips to occur in the carrier phase observation of the attitude determination system using the global positioning system (GPS), especially in the dynamic situation. Therefore, in order to reject the error by cycle slips, the integer ambiguity should be re-computed. A motion model-based Kalman predictor is used for the ambiguity re-computation in dynamic applications. This method utilizes the correct observation of the last step to predict the current ambiguities. With the baseline length as a constraint to reject invalid values, we can solve the current integer ambiguity and the attitude angles, by substituting the obtained ambiguities into the constrained LAMBDA method. Experimental results demonstrate that the proposed method is more efficient in the dynamic situation, which takes less time to obtain new fixed ambiguities with a higher mean success rate

Association between eating disorders and body image in athletes and non-athlete students in Qazvin University of Medical Sciences

Directory of Open Access Journals (Sweden)

M. Miri

2016-06-01

Full Text Available Background: Body image dissatisfaction and eating disorders are of common problems in adolescence and adulthood especially among athletes. Objective: The aim of this study was to determine the association of eating disorders and body image in athletes and non-athlete students in Qazvin University of Medical Sciences. Methods: This cross-sectional study was conducted on 226 athlete students and 350 non-athlete students of Qazvin University of Medical Sciences during 2013-2014. Students who followed a specific sport field and had participated in at least one sport event were considered as athlete students. All athlete students were entered the study by census method. Non-athlete students were selected among students who had not any exercise activity and by random sampling method. Data were collected through demographic questionnaire, Eating Attitudes Test (EAT-26, and Multidimensional Body-Self Relations Questionnaire (MBSRQ. Data were analyzed using T-test and Chi-square test. Results: Mean age was 21.92±3.19 years and mean body mass index (BMI was 22.24±3.18 kg/m2. The frequency of eating disorders was 11.5% among the athlete students and 11.2% among the non-athlete students. Anorexia nervosa was found to be more prevalent than bulimia nervosa in both groups. The students with normal BMI had better body image perception and less eating disorders symptoms than other students. The association of age, educational level, and gender with eating disorders and body image was not statistically significant. The association of eating disorders and body image was not statistically significant. Eating disorders were more prevalent in males than females but the difference was not statistically significant. Conclusion: With regards to the results, it seems that eating disorders and body image dissatisfaction are relatively prevalent among both athletes and non-athlete students and BMI is predictor of eating disorders.

A novel measuring method for arbitrary optical vortex by three spiral spectra

Energy Technology Data Exchange (ETDEWEB)

Ni, Bo [School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006 (China); Guo, Lana [School of Electronics and Information, Guangdong Polytechnic Normal University, Guangzhou 510665 (China); Yue, Chengfeng [School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006 (China); Tang, Zhilie, E-mail: tangzhl@scnu.edu.cn [School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006 (China)

2017-02-26

In this letter, the topological charge of non-integer vortices determined by three arbitrary spiral spectra is theoretically demonstrated for the first time. Based on the conclusion, a novel method to measure non-integer vortices is presented. This method is applicable not only to arbitrary non-integer vortex but also to arbitrary integer vortex. - Highlights: • Different non-integer vortices cannot have three spiral spectra is demonstrated. • Relationship between the non-integer topological charge and the spiral spectra is presented. • Topological charge of non-integer vortices can be determined by three arbitrary spiral spectra.

[Non-speech oral motor treatment efficacy for children with developmental speech sound disorders].

Science.gov (United States)

Ygual-Fernandez, A; Cervera-Merida, J F

2016-01-01

In the treatment of speech disorders by means of speech therapy two antagonistic methodological approaches are applied: non-verbal ones, based on oral motor exercises (OME), and verbal ones, which are based on speech processing tasks with syllables, phonemes and words. In Spain, OME programmes are called 'programas de praxias', and are widely used and valued by speech therapists. To review the studies conducted on the effectiveness of OME-based treatments applied to children with speech disorders and the theoretical arguments that could justify, or not, their usefulness. Over the last few decades evidence has been gathered about the lack of efficacy of this approach to treat developmental speech disorders and pronunciation problems in populations without any neurological alteration of motor functioning. The American Speech-Language-Hearing Association has advised against its use taking into account the principles of evidence-based practice. The knowledge gathered to date on motor control shows that the pattern of mobility and its corresponding organisation in the brain are different in speech and other non-verbal functions linked to nutrition and breathing. Neither the studies on their effectiveness nor the arguments based on motor control studies recommend the use of OME-based programmes for the treatment of pronunciation problems in children with developmental language disorders.

Scheduling of head-dependent cascaded hydro systems: Mixed-integer quadratic programming approach

Energy Technology Data Exchange (ETDEWEB)

Catalao, J.P.S.; Pousinho, H.M.I. [Department of Electromechanical Engineering, University of Beira Interior, R. Fonte do Lameiro, 6201-001 Covilha (Portugal); Mendes, V.M.F. [Department of Electrical Engineering and Automation, Instituto Superior de Engenharia de Lisboa, R. Conselheiro Emidio Navarro, 1950-062 Lisbon (Portugal)

2010-03-15

This paper is on the problem of short-term hydro scheduling, particularly concerning head-dependent cascaded hydro systems. We propose a novel mixed-integer quadratic programming approach, considering not only head-dependency, but also discontinuous operating regions and discharge ramping constraints. Thus, an enhanced short-term hydro scheduling is provided due to the more realistic modeling presented in this paper. Numerical results from two case studies, based on Portuguese cascaded hydro systems, illustrate the proficiency of the proposed approach. (author)

Measurement of runaway electron energy distribution function during high-Z gas injection into runaway electron plateaus in DIII-Da)

Energy Technology Data Exchange (ETDEWEB)

Hollmann, E. M. [University of California—San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA; Parks, P. B. [General Atomics, PO Box 85608, San Diego, California 92186, USA; Commaux, N. [Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, Tennessee 37831, USA; Eidietis, N. W. [General Atomics, PO Box 85608, San Diego, California 92186, USA; Moyer, R. A. [University of California—San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA; Shiraki, D. [Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, Tennessee 37831, USA; Austin, M. E. [Institute for Fusion Studies, University of Texas—Austin, 2100 San Jacinto Blvd, Austin, Texas 78712, USA; Lasnier, C. J. [Lawrence Livermore National Laboratory, 7000 East Ave, Livermore, California 94550, USA; Paz-Soldan, C. [General Atomics, PO Box 85608, San Diego, California 92186, USA; Rudakov, D. L. [University of California—San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA

2015-05-01

The evolution of the runaway electron (RE) energy distribution function fεfε during massive gas injection into centered post-disruption runaway electron plateaus has been reconstructed. Overall, fεfε is found to be much more skewed toward low energy than predicted by avalanche theory. The reconstructions also indicate that the RE pitch angle θ is not uniform, but tends to be large at low energies and small θ ~0.1–0.2 at high energies. Overall power loss from the RE plateau appears to be dominated by collisions with background free and bound electrons, leading to line radiation. However, the drag on the plasma current appears to be dominated by collisions with impurity ions in most cases. Synchrotron emission appears not to be significant for overall RE energy dissipation but may be important for limiting the peak RE energy.

Measurement of runaway electron energy distribution function during high-Z gas injection into runaway electron plateaus in DIII-D

International Nuclear Information System (INIS)

Hollmann, E. M.; Moyer, R. A.; Rudakov, D. L.; Parks, P. B.; Eidietis, N. W.; Paz-Soldan, C.; Commaux, N.; Shiraki, D.; Austin, M. E.; Lasnier, C. J.

2015-01-01

The evolution of the runaway electron (RE) energy distribution function f ε during massive gas injection into centered post-disruption runaway electron plateaus has been reconstructed. Overall, f ε is found to be much more skewed toward low energy than predicted by avalanche theory. The reconstructions also indicate that the RE pitch angle θ is not uniform, but tends to be large at low energies and small θ ∼ 0.1–0.2 at high energies. Overall power loss from the RE plateau appears to be dominated by collisions with background free and bound electrons, leading to line radiation. However, the drag on the plasma current appears to be dominated by collisions with impurity ions in most cases. Synchrotron emission appears not to be significant for overall RE energy dissipation but may be important for limiting the peak RE energy

Visual and non-visual motion information processing during pursuit eye tracking in schizophrenia and bipolar disorder.

Science.gov (United States)

Trillenberg, Peter; Sprenger, Andreas; Talamo, Silke; Herold, Kirsten; Helmchen, Christoph; Verleger, Rolf; Lencer, Rebekka

2017-04-01

Despite many reports on visual processing deficits in psychotic disorders, studies are needed on the integration of visual and non-visual components of eye movement control to improve the understanding of sensorimotor information processing in these disorders. Non-visual inputs to eye movement control include prediction of future target velocity from extrapolation of past visual target movement and anticipation of future target movements. It is unclear whether non-visual input is impaired in patients with schizophrenia. We recorded smooth pursuit eye movements in 21 patients with schizophrenia spectrum disorder, 22 patients with bipolar disorder, and 24 controls. In a foveo-fugal ramp task, the target was either continuously visible or was blanked during movement. We determined peak gain (measuring overall performance), initial eye acceleration (measuring visually driven pursuit), deceleration after target extinction (measuring prediction), eye velocity drifts before onset of target visibility (measuring anticipation), and residual gain during blanking intervals (measuring anticipation and prediction). In both patient groups, initial eye acceleration was decreased and the ability to adjust eye acceleration to increasing target acceleration was impaired. In contrast, neither deceleration nor eye drift velocity was reduced in patients, implying unimpaired non-visual contributions to pursuit drive. Disturbances of eye movement control in psychotic disorders appear to be a consequence of deficits in sensorimotor transformation rather than a pure failure in adding cognitive contributions to pursuit drive in higher-order cortical circuits. More generally, this deficit might reflect a fundamental imbalance between processing external input and acting according to internal preferences.

Spacetime dependence of the anomalous exponent of electric transport in the disorder model

International Nuclear Information System (INIS)

Egami, Takeshi; Suzuki, Koshiro; Watanabe, Katsuhiro

2012-01-01

Spacetime dependence of the anomalous exponent of electric transport in the disorder model is investigated. We show that the anomalous exponent evolves with time, according to the time evolution of the number of the effective neighbouring sites. Transition from subdiffusive to normal transport is recovered at macroscopic timescales. Plateaus appear in the history of the anomalous exponent due to the discreteness of the hopping sites, which is compatible with the conventional treatment to regard the anomalous exponent as a constant. We also show that, among various microscopic spatial structures, the number of the effective neighbouring sites is the only element which determines the anomalous exponent. This is compatible with the mesoscopic model of Scher–Montroll. These findings are verified by means of Monte Carlo simulation. The well-known expression of the anomalous exponent in the conventional multiple trapping model is derived by deducing it as a special case of the disorder model. (paper)

The Influence of Gender, Age, Psychological Resilience and Family Interaction Factors upon Anxiety and Depression in Non-Autism Spectrum Disorder Siblings of Children with an Autism Spectrum Disorder

Science.gov (United States)

Bitsika, Vicki; Sharpley, Christopher F.; Mailli, Rebecca

2015-01-01

The influence of gender, age, Psychological resilience and family interaction factors upon generalised anxiety disorder (GAD) and major depressive disorder (MDD) was investigated in 75 non-autism spectrum disorder (NASD) siblings who had a brother or sister with an autism spectrum disorder (ASD). GAD and MDD were much more prevalent than in…

Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology.

Science.gov (United States)

Guloksuz, S; van Nierop, M; Lieb, R; van Winkel, R; Wittchen, H-U; van Os, J

2015-08-01

Evidence suggests that in affective, non-psychotic disorders: (i) environmental exposures increase risk of subthreshold psychotic experiences (PEs) and strengthen connectivity between domains of affective and subthreshold psychotic psychopathology; and (ii) PEs are a marker of illness severity. In 3021 adolescents from the Early Developmental Stages of Psychopathology cohort, we tested whether the association between PEs and presence of DSM-IV mood disorder (MD)/obsessive-compulsive disorder (OCD) would be moderated by risk factors for psychosis (cannabis use, childhood trauma and urbanicity), using the interaction contrast ratio (ICR) method. Furthermore, we analysed whether the interaction between environment and PEs was mediated by non-psychotic psychopathology. The association between PEs and MD/OCD was moderated by urbanicity (ICR = 2.46, p = 0.005), cannabis use (ICR = 3.76, p = 0.010) and, suggestively, trauma (ICR = 1.91, p = 0.063). Exposure to more than one environmental risk factor increased the likelihood of co-expression of PEs in a dose-response fashion. Moderating effects of environmental exposures were largely mediated by the severity of general non-psychotic psychopathology (percentage explained 56-68%, all p psychopathology. The findings are compatible with a relational model of psychopathology in which more severe clinical states are the result of environment-induced disturbances spreading through a psychopathology network.

Discrete Ziggurat: A time-memory trade-off for sampling from a Gaussian distribution over the integers

NARCIS (Netherlands)

Buchmann, J.; Cabarcas, D.; Göpfert, F.; Hülsing, A.T.; Weiden, P.; Lange, T.; Lauter, K.; Lisonek, P.

2014-01-01

Several lattice-based cryptosystems require to sample from a discrete Gaussian distribution over the integers. Existing methods to sample from such a distribution either need large amounts of memory or they are very slow. In this paper we explore a different method that allows for a flexible

Optimising the selection of food items for food frequency questionnaires using Mixed Integer Linear Programming

NARCIS (Netherlands)

Lemmen-Gerdessen, van J.C.; Souverein, O.W.; Veer, van 't P.; Vries, de J.H.M.

2015-01-01

Objective To support the selection of food items for FFQs in such a way that the amount of information on all relevant nutrients is maximised while the food list is as short as possible. Design Selection of the most informative food items to be included in FFQs was modelled as a Mixed Integer Linear

Optimal placement of capacitors in a radial network using conic and mixed integer linear programming

Energy Technology Data Exchange (ETDEWEB)

Jabr, R.A. [Electrical, Computer and Communication Engineering Department, Notre Dame University, P.O. Box: 72, Zouk Mikhael, Zouk Mosbeh (Lebanon)

2008-06-15

This paper considers the problem of optimally placing fixed and switched type capacitors in a radial distribution network. The aim of this problem is to minimize the costs associated with capacitor banks, peak power, and energy losses whilst satisfying a pre-specified set of physical and technical constraints. The proposed solution is obtained using a two-phase approach. In phase-I, the problem is formulated as a conic program in which all nodes are candidates for placement of capacitor banks whose sizes are considered as continuous variables. A global solution of the phase-I problem is obtained using an interior-point based conic programming solver. Phase-II seeks a practical optimal solution by considering capacitor sizes as discrete variables. The problem in this phase is formulated as a mixed integer linear program based on minimizing the L1-norm of deviations from the phase-I state variable values. The solution to the phase-II problem is obtained using a mixed integer linear programming solver. The proposed method is validated via extensive comparisons with previously published results. (author)

An Integer Programming Formulation of the Minimum Common String Partition Problem.

Directory of Open Access Journals (Sweden)

S M Ferdous

Full Text Available We consider the problem of finding a minimum common string partition (MCSP of two strings, which is an NP-hard problem. The MCSP problem is closely related to genome comparison and rearrangement, an important field in Computational Biology. In this paper, we map the MCSP problem into a graph applying a prior technique and using this graph, we develop an Integer Linear Programming (ILP formulation for the problem. We implement the ILP formulation and compare the results with the state-of-the-art algorithms from the literature. The experimental results are found to be promising.

Decreased Somatosensory Activity to Non-threatening Touch in Combat Veterans with Posttraumatic Stress Disorder

OpenAIRE

Badura-Brack, Amy S.; Becker, Katherine M.; McDermott, Timothy J.; Ryan, Tara J.; Becker, Madelyn M.; Hearley, Allison R.; Heinrichs-Graham, Elizabeth; Wilson, Tony W.

2015-01-01

Posttraumatic stress disorder (PTSD) is a severe psychiatric disorder prevalent in combat veterans. Previous neuroimaging studies have demonstrated that patients with PTSD exhibit abnormal responses to non-threatening visual and auditory stimuli, but have not examined somatosensory processing. Thirty male combat veterans, 16 with PTSD and 14 without, completed a tactile stimulation task during a 306-sensor magnetoencephalography (MEG) recording. Significant oscillatory neural responses were i...

Temperament traits in suicidal and non-suicidal mood disorder patients in Taiwan.

Science.gov (United States)

Liu, Shen-Ing; Huang, Yu-Hsin; Wu, Ying-Hui; Huang, Kuo-Yang; Huang, Hui-Chun; Sun, Fang-Ju; Huang, Chiu-Ron; Sung, Ming-Ru; Huang, Yo-Ping

2017-07-01

Suicide is a major social and clinical problem in Asia. Although studies have suggested that personality traits are possible risk factors for suicide, no study has been conducted among Chinese to compare the temperament traits of suicidal and non-suicidal mood disorder patients with those of healthy controls. This study compared temperament traits of two patient groups, those with a mood disorder who have attempted suicide (n=204), and those with a mood disorder who have not attempted suicide (n=160), and compared the traits of these patients to those of healthy controls (n=178), assessed by Cloninger's Tridimensional Personality Questionnaire and the Brown-Goodwin Aggression Inventory. Patients with suicidal attempts had significantly higher novelty seeking and aggression scores than healthy controls and patients without suicidal attempts. Two groups of patients with mood disorder had significantly higher harm avoidance scores than the healthy controls. However, patients with suicidal attempts did not have higher harm avoidance scores than patients without suicidal attempts. This study confirms findings that harm avoidance and mood disorder are related, and extends them by suggesting that those with a mood disorder and suicide attempts have higher novelty seeking and lifetime aggression scores than those without suicidal attempt, either patients or healthy controls. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Globular and disordered – the non-identical twins in protein-protein interactions

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Kaare eTeilum

2015-07-01

Full Text Available In biology proteins from different structural classes interact across and within classes in ways that are optimized to achieve balanced functional outputs. The interactions between intrinsically disordered proteins (IDPs and other proteins rely on changes in flexibility and this is seen as a strong determinant for their function. This has fostered the notion that IDP’s bind with low affinity but high specificity. Here we have analyzed available detailed thermodynamic data for protein-protein interactions to put to the test if the thermodynamic profiles of IDP interactions differ from those of other protein-protein interactions. We find that ordered proteins and the disordered ones act as non identical twins operating by similar principles but where the disordered proteins complexes are on average less stable by 2.5 kcal mol-1.

Penempatan Optimal Phasor Measurement Unit (PMU dengan Integer Programming

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Yunan Helmy Amrulloh

2013-09-01

Full Text Available Phasor Measurement Unit (PMU merupakan peralatan yang mampu memberikan pengukuran fasor tegangan dan arus secara real-time. PMU dapat digunakan untuk monitoring, proteksi dan kontrol pada sistem tenaga listrik. Tugas akhir ini membahas penempatan PMU secara optimal berdasarkan topologi jaringan sehingga sistem tenaga listrik  dapat diobservasi. Penempatan optimal PMU dirumuskan sebagai masalah Binary Integer Programming (BIP yang akan memberikan variabel dengan pilihan nilai (0,1 yang menunjukkan tempat yang harus dipasang PMU. Dalam tugas akhir ini, BIP diterapkan untuk menyelesaikan masalah penempatan PMU secara optimal pada sistem tenaga listrik  Jawa-Bali 500 KV yang selanjutnya diterapkan dengan penambahan konsep incomplete observability. Hasil simulasi menunjukkan bahwa penerapan BIP pada sistem dengan incomplete observability memberikan jumlah PMU yang lebih sedikit dibandingkan dengan sistem tanpa konsep incomplete observability.

Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients

NARCIS (Netherlands)

Kupka, RW; Luckenbaugh, DA; Post, RM; Suppes, T; Altshuler, LL; Keck, PE; Frye, MA; Denicoff, KD; Grunze, H; Leverich, GS; McElroy, SL; Walden, J; Nolen, WA

Objective: To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective. Method: Outpatients with bipolar I disorder (N = 419), bipolar II disorder (N = 104),

Integrative improvement method and mixed-integer programming in system planning

International Nuclear Information System (INIS)

Sadegheih, A.

2002-01-01

In this paper, system planning network is formulated for mixed-integer programming and a Ga. The cost function of this problem consists of the capital investment cost in discrete form, the cost of transmission losses and the power generation costs. The Dc load flow equations for the network are embedded in the constraints of the mathematical model to avoid sub-optimal solutions that can arise if the enforcement of such constraints is done in an indirect way. The solution of the model gives the best line additions. and also provides information regarding the optimal generation at each generation point. This method of solutions is demonstrated on the expansion of a 5 bus -bar system to 6 bus-bars

The integer quantum hall effect revisited

Energy Technology Data Exchange (ETDEWEB)

Michalakis, Spyridon [Los Alamos National Laboratory; Hastings, Matthew [Q STATION, CALIFORNIA

2009-01-01

For T - L x L a finite subset of Z{sup 2}, let H{sub o} denote a Hamiltonian on T with periodic boundary conditions and finite range, finite strength intetactions and a unique ground state with a nonvanishing spectral gap. For S {element_of} T, let q{sub s} denote the charge at site s and assume that the total charge Q = {Sigma}{sub s {element_of} T} q{sub s} is conserved. Using the local charge operators q{sub s}, we introduce a boundary magnetic flux in the horizontal and vertical direction and allow the ground state to evolve quasiadiabatically around a square of size one magnetic flux, in flux space. At the end of the evolution we obtain a trivial Berry phase, which we compare, via a method reminiscent of Stokes Theorem. to the Berry phase obtained from an evolution around an exponentially small loop near the origin. As a result, we show, without any averaging assumption, that the Hall conductance is quantized in integer multiples of e{sup 2}/h up to exponentially small corrections of order e{sup -L/{zeta}}, where {zeta}, is a correlation length that depends only on the gap and the range and strength of the interactions.

Associations between high callous-unemotional traits and quality of life across youths with non-conduct disorder diagnoses.

Science.gov (United States)

Herpers, Pierre C M; Klip, Helen; Rommelse, Nanda N J; Greven, Corina U; Buitelaar, Jan K

2016-05-01

Research regarding callous-unemotional (CU) traits in non-conduct disorder (CD) diagnoses is sparse. We investigated the presence of high CU traits and their associations with quality of life (QoL) in a clinically referred sample of youths with non-CD diagnoses. Parents of 1018 children referred to a child and adolescent psychiatric clinic and rated their child's CU traits and QoL. Experienced clinicians derived DSM-IV-TR diagnoses based on systematic clinical evaluations of these children. High CU traits compared to low CU traits were present in 38.5 % of the sample, and more often in boys than girls (69.4 vs. 30.6 %, p = .004), and were associated with more police contacts (12.2 vs. 3.5 %, p disorder (odds ratio; OR = 1.61; 95 % CI 1.24-2.09; p disorder not otherwise specified/oppositional defiant disorder (OR = 4.98; 95 % CI 2.93-8.64; p disorder (OR = 1.01; 95 % CI .79-1.31; p = .94), were more likely to have high than low CU traits. Those with anxiety/mood disorders were more likely to have low than high CU traits (OR = .59; 95 % CI .42-82; p = .002). In all diagnostic groups, high CU compared to low CU traits were associated with significantly lower QoL, while controlling for gender, age, and comorbidity. As such, high CU traits significantly modify QoL in non-CD disorders.

Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders

DEFF Research Database (Denmark)

Ljungdalh, P. M.

2017-01-01

Background and objectives The primary treatment for schizophrenia and schizophrenia-spectrum disorders is antipsychotic medication. One of the many public health challenges in mental illness, is to identify contributing factors to non-adherence to pharmacological treatment. The objective...... of this study was to perform an updated systematic review of risk factors for non-adherence to pharmacological treatment in schizophrenia in a European and American context. Methods The study was a systematic literature review of studies that included at least two measurements of pharmacological adherence...... of illness, alcohol or drug abuse and unspecified younger age. Conclusions The findings in this systematic literature review are consistent with previous reviews on non-adherence and schizophrenia. It stresses the methodological challenges in psychiatric adherence research and establishes the need for more...

A Statistically-Hiding Integer Commitment Scheme Based on Groups with Hidden Order

DEFF Research Database (Denmark)

Damgård, Ivan Bjerre; Fujisaki, Eiichiro

2002-01-01

We present a statistically-hiding commitment scheme allowing commitment to arbitrary size integers, based on any (Abelian) group with certain properties, most importantly, that it is hard for the committer to compute its order. We also give efficient zero-knowledge protocols for proving knowledge...... input is chosen by the (possibly cheating) prover. -  - Our results apply to any group with suitable properties. In particular, they apply to a much larger class of RSA moduli than the safe prime products proposed in [14] - Potential examples include RSA moduli, class groups and, with a slight...

Genetic Algorithm for Mixed Integer Nonlinear Bilevel Programming and Applications in Product Family Design

OpenAIRE

Chenlu Miao; Gang Du; Yi Xia; Danping Wang

2016-01-01

Many leader-follower relationships exist in product family design engineering problems. We use bilevel programming (BLP) to reflect the leader-follower relationship and describe such problems. Product family design problems have unique characteristics; thus, mixed integer nonlinear BLP (MINLBLP), which has both continuous and discrete variables and multiple independent lower-level problems, is widely used in product family optimization. However, BLP is difficult in theory and is an NP-hard pr...

Behavioral Heterogeneity Affects Individual Performances in Experimental and Computational Lowest Unique Integer Games

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Takashi Yamada

2017-12-01

Full Text Available This study computationally examines (1 how the behaviors of subjects are represented, (2 whether the classification of subjects is related to the scale of the game, and (3 what kind of behavioral models are successful in small-sized lowest unique integer games (LUIGs. In a LUIG, N (≥ 3 players submit a positive integer up to M(> 1 and the player choosing the smallest number not chosen by anyone else wins. For this purpose, the author considers four LUIGs with N = {3, 4} and M = {3, 4} and uses the behavioral data obtained in the laboratory experiment by Yamada and Hanaki [1]. For computational experiments, the author calibrates the parameters of typical learning models for each subject and then pursues round robin competitions. The main findings are in the following: First, the subjects who played not differently from the mixed-strategy Nash equilibrium (MSE prediction tended to made use of not only their choices but also the game outcomes. Meanwhile those who deviated from the MSE prediction took care of only their choices as the complexity of the game increased. Second, the heterogeneity of player strategies depends on both the number of players (N and the upper limit (M. Third, when groups consist of different agents like in the earlier laboratory experiment, sticking behavior is quite effective to win.

Behavioral heterogeneity affects individual performances in experimental and computational lowest unique integer games

Science.gov (United States)

Yamada, Takashi

2017-12-01

This study computationally examines (1) how the behaviors of subjects are represented, (2) whether the classification of subjects is related to the scale of the game, and (3) what kind of behavioral models are successful in small-sized lowest unique integer games (LUIGs). In a LUIG, N (>= 3) players submit a positive integer up to M(> 1) and the player choosing the smallest number not chosen by anyone else wins. For this purpose, the author considers four LUIGs with N = {3, 4} and M = {3, 4} and uses the behavioral data obtained in the laboratory experiment by Yamada and Hanaki (Physica A 463, pp. 88–102, 2016). For computational experiments, the author calibrates the parameters of typical learning models for each subject and then pursues round robin competitions. The main findings are in the following: First, the subjects who played not differently from the mixed-strategy Nash equilibrium (MSE) prediction tended to made use of not only their choices but also the game outcomes. Meanwhile those who deviated from the MSE prediction took care of only their choices as the complexity of the game increased. Second, the heterogeneity of player strategies depends on both the number of players (N) and the upper limit (M). Third, when groups consist of different agents like in the earlier laboratory experiment, sticking behavior is quite effective to win.

FAST INTEGER AMBIGUITY RESOLUTION IN GPS KINEMATIC POSITIONING USING LEFT NULL SPACE AND MULTI-TIME (INVERSE PAIRED CHOLESKY DECORRELATION

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Rong Duan

Full Text Available Aiming at the problems that huge amount of computation in ambiguity resolution with multiple epochs and high-order matrix inversion occurred in the GPS kinematic relative positioning, a modified algorithm for fast integer ambiguity resolution is proposed. Firstly, Singular Value Decomposition (SVD is applied to construct the left null space matrix in order to eliminate the baselines components, which is able to separate ambiguity parameters from the position parameters efficiently. Kalman filter is applied only to estimate the ambiguity parameters so that the real-time ambiguity float solution is obtained. Then, sorting and multi-time (inverse paired Cholesky decomposition are adopted for decorrelation of ambiguity. After diagonal elements preprocessing and diagonal elements sorting according to the results of Cholesky decomposition, the efficiency of decomposition and decorrelation is improved. Lastly, the integer search algorithm implemented in LAMBDA method is used for searching the integer ambiguity. To verify the validity and efficacy of the proposed algorithm, static and kinematic tests are carried out. Experimental results show that this algorithm has good performance of decorrelation and precision of float solution, with computation speed also increased effectively. The final positioning accuracy result with static baseline error less than 1 cm and kinematic error less than 2 cm, which indicates that it can be used for fast kinematic positioning of high precision carrier.

Exploring Groundwater origin for theater-headed valleys on the walls of Ius Chasma based on geomorphological analogy to the Saharan Plateaus

Science.gov (United States)

Farag, A. Z. A.; Heggy, E.; Mohamed, R.

2017-12-01

Understanding the origin and evolution of Martian fluvial landforms constrains the ambiguities associated to the variability of paleoclimatic and hydrological conditions. Despite of the significance of understanding the mechanism of formation of theater-headed valleys (THV) in Valles Mariners, where abundant distribution of seasonal liquid water flow is reported, their origin remains debatable. The original groundwater sapping hypothesis is challenged by the capability of springs to cut canyons into massive rocks and alternatively mega-floods and landslides were suggested. On Earth however, widespread THV cutting through the carbonate plateaus in the Sahara are confirmed to be of long-lasting groundwater processes based on recent isotopic, geochemical and hydrogeological evidences. Geomorphological characterizations of the THV in both the Sahara and in Valles Marineris suggest similar settings including: (1) widespread and dense occurrence along the length of escarpments, (2) low relief floors, (3) association with extensive faulting, and (4) lack of well-developed stream networks and small upstream contributing areas. The above suggest that both the Martian and the Saharan THV to be of groundwater origins. Herein, we constraint the geomorphological, lithological and textural characteristics of THV in El Diffa and El-Merir plateaus in the Eastern Sahara as a limited analog to the THV in Ius Chasma using structural and textural mapping derived from ALOS PalSAR scenes and similar settings on Mars using SHARAD, MOLA and HIRISE images. These observations are correlated with several in-situ field and laboratory measurements for hardness, granulometry and channel morphology to support the common phenomenology. Preliminary findings show that in both sets of THV, we observe a spatial confinement of boulders to the sidewalls with relatively finer grains along the channel courses, and association with large-scale hydrated sulphates along the sidewalls and channel bottoms

How to build institutionalization on students: a pilot experiment on a didactical design of addition and subtraction involving negative integers

Science.gov (United States)

Fuadiah, N. F.; Suryadi, D.; Turmudi

2018-05-01

This study focuses on the design of a didactical situation in addition and subtraction involving negative integers at the pilot experiment phase. As we know, negative numbers become an obstacle for students in solving problems related to them. This study aims to create a didactical design that can assist students in understanding the addition and subtraction. Another expected result in this way is that students are introduced to the characteristics of addition and subtraction of integers. The design was implemented on 32 seventh grade students in one of the classes in a junior secondary school as the pilot experiment. Learning activities were observed thoroughly including the students’ responses that emerged during the learning activities. The written documentation of the students was also used to support the analysis in the learning activities. The results of the analysis showed that this method could help the students perform a large number of integer operations that could not be done with a number line. The teacher’s support as a didactical potential contract was still needed to encourage institutionalization processes. The results of the design analysis used as the basis of the revision are expected to be implemented by the teacher in the teaching experiment.

Organic and Non-Organic Language Disorders after Awake Brain Surgery

Directory of Open Access Journals (Sweden)

Elke De Witte

2014-04-01

Full Text Available INTRODUCTION: Awake surgery with Direct Electrical Stimulation (DES is considered the ‘gold standard’ to resect brain tumours in the language dominant hemisphere (De Witte & Mariën, 2013. Although transient language impairments are common in the immediate postoperative phase, permanent postoperative language deficits seem to be rare (Duffau, 2007. Milian et al. (2014 stated that most patients tolerate the awake procedure well and would undergo a similar procedure again. However, postoperative psychological symptoms including recurrent distressing dreams and persistent avoidance of stimuli have been recorded following awake surgery (Goebel, Nabavi, Schubert, & Mehdorn, 2010; Milian et al., 2014. To the best of our knowledge, psychogenic language disturbances have never been described after awake surgery. In general, only a handful of non-organic, psychogenic language disorders have been reported in the literature (De Letter et al., 2012. We report three patients with left brain tumours (see table 1 who presented linguistic symptoms after awake surgery that were incompatible with the lesion location, suggesting a psychogenic origin. METHODS: Neurocognitive (language, memory, executive functions investigations were carried out before, during and after awake surgery (6 weeks, 6 months postsurgery on the basis of standardised tests. Pre- and postoperative (fMRI images, DTI results and intraoperative DES findings were analysed. A selection of tasks was used to map language intraoperatively (De Witte et al., 2013. In the postoperative phase spontaneous speech and behavioural phenomena to errors were video-recorded. RESULTS: Preoperative language tests did not reveal any speech or language problems. Intraoperatively, eloquent sites were mapped and preserved enabling good language skills at the end of the awake procedure. However, assessments in the first weeks postsurgery disclosed language and behavioural symptoms that support the hypothesis of a

Non-breathing-related sleep disorders following stroke.

Science.gov (United States)

Marquez-Romero, J M; Morales-Ramírez, M; Arauz, A

2014-01-01

It has been shown that sleep-related breathing disorders, especially sleep apnea, are very common in patients who have had a stroke, and that they also reduce the potential for neurological recovery. Nevertheless, other sleep disorders caused by stroke (excessive daytime sleepiness, insomnia, sleep related movement disorders) can also cause or increase stroke-related disability, and this fact is less commonly known. Studies with polysomnography have shown many abnormalities in sleep architecture during the acute phase of stroke; these abnormalities have a negative impact on the patient's quality of life although they tend to improve with time. This also happens with other sleep disorders occurring as the result of a stroke (insomnia, narcolepsy, restless legs syndrome, periodic limb movement disorder and REM sleep behavior disorder), which are nevertheless potentially treatable. In this article, we briefly review the physiopathology and epidemiology of the disorders listed above in order to raise awareness about the importance of these disorders and the effects they elicit in stroke patients. Sleep disorders that are not breathing-related have scarcely been studied in stroke patients despite the fact that almost all such disorders may present as a result of a cerebrovascular event. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Estimating aboveground forest biomass carbon and fire consumption in the U.S. Utah High Plateaus using data from the Forest Inventory and Analysis program, Landsat, and LANDFIRE

Science.gov (United States)

Chen, Xuexia; Liu, Shuguang; Zhu, Zhiliang; Vogelmann, James E.; Li, Zhengpeng; Ohlen, Donald O.

2011-01-01

The concentrations of CO2 and other greenhouse gases in the atmosphere have been increasing and greatly affecting global climate and socio-economic systems. Actively growing forests are generally considered to be a major carbon sink, but forest wildfires lead to large releases of biomass carbon into the atmosphere. Aboveground forest biomass carbon (AFBC), an important ecological indicator, and fire-induced carbon emissions at regional scales are highly relevant to forest sustainable management and climate change. It is challenging to accurately estimate the spatial distribution of AFBC across large areas because of the spatial heterogeneity of forest cover types and canopy structure. In this study, Forest Inventory and Analysis (FIA) data, Landsat, and Landscape Fire and Resource Management Planning Tools Project (LANDFIRE) data were integrated in a regression tree model for estimating AFBC at a 30-m resolution in the Utah High Plateaus. AFBC were calculated from 225 FIA field plots and used as the dependent variable in the model. Of these plots, 10% were held out for model evaluation with stratified random sampling, and the other 90% were used as training data to develop the regression tree model. Independent variable layers included Landsat imagery and the derived spectral indicators, digital elevation model (DEM) data and derivatives, biophysical gradient data, existing vegetation cover type and vegetation structure. The cross-validation correlation coefficient (r value) was 0.81 for the training model. Independent validation using withheld plot data was similar with r value of 0.82. This validated regression tree model was applied to map AFBC in the Utah High Plateaus and then combined with burn severity information to estimate loss of AFBC in the Longston fire of Zion National Park in 2001. The final dataset represented 24 forest cover types for a 4 million ha forested area. We estimated a total of 353 Tg AFBC with an average of 87 MgC/ha in the Utah High

Two-Part Models for Fractional Responses Defined as Ratios of Integers

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Harald Oberhofer

2014-09-01

Full Text Available This paper discusses two alternative two-part models for fractional response variables that are defined as ratios of integers. The first two-part model assumes a Binomial distribution and known group size. It nests the one-part fractional response model proposed by Papke and Wooldridge (1996 and, thus, allows one to apply Wald, LM and/or LR tests in order to discriminate between the two models. The second model extends the first one by allowing for overdispersion in the data. We demonstrate the usefulness of the proposed two-part models for data on the 401(k pension plan participation rates used in Papke and Wooldridge (1996.

Non-Born-Oppenheimer Spectroscopy of Cyclic Triatomics

Science.gov (United States)

2011-10-11

n nmnm mn m nm nm nm nm ss n IV E 2/ if,2/1 2/ if, ])2/1()/[( )2/1()/( 2 1 12 22 222 22 2/,,4 23 )3(   Here ZPE ...integer values of m . The perturbation theory expression gives us seven parameters for a non-linear fitting problem: ZPE , 0I , 1I , 2I , 3V , 6V and

Language Disorders Comparative Study in Patients with Paranoid and Non-Paranoid Schizophrenia

Directory of Open Access Journals (Sweden)

Farzam Parva

2004-10-01

Full Text Available Objective: The main purpose of this study was the assay of language disorders in paranoid and non – paranoid long-stay Schizophrenic patients in Razi Psychiatric Center. Materials & Methods: Language disorders in 40 Schizophrenic Patients who were divided in 2 groups (paranoid and non – paranoid No: 20 male and female and studied by using Farsi Aphasia Test. All of the subjects were matched on the basis of gender, age, education, duration of illness and length of stay in hospital. The evaluated language skills were composed of Spontaneus Verbal Fluency, Descriptive Verbal Fluency, Quality of Spontaneus Speech, Quality of Descriptive Speech, Listening Comprehension, Oral Reading (Expression, Written Comprehension, Writing, (words, Repetition and Number of Words. Data were analysed by using of SPSS windows analysis. Results: show a global reduction in scores of skills compared with normal subjects and the most reduction is seen in Quality of Descriptive Speech, Fluency of Descriptive speech and Number of Words Skills. Conclusion: Paranoid patients versus non paranoids show significant differences in Fluency of Descriptive Speech, Listening Comprehension, Oral Reading and Number of Words, and global score of the test. among demographic variants, only educational situation has significant relevance with some items of the test.

Tasimelteon (Hetlioz™): A New Melatonin Receptor Agonist for the Treatment of Non-24-Hour Sleep-Wake Disorder.

Science.gov (United States)

Bonacci, Janene M; Venci, Jineane V; Gandhi, Mona A

2015-10-01

In January 2014, the US Food and Drug Administration approved tasimelteon (Hetlioz™), a melatonin-receptor agonist for the treatment of non-24-hour sleep-wake disorder. This article provides an overview of the mechanism of action, pharmacokinetic properties, as well as the clinical efficacy, safety, and tolerability of tasimelteon. Relevant information was identified through a comprehensive literature search of several databases using the key words tasimelteon, Non-24-hour Sleep-Wake disorder, Non-24, and melatonin. Further information was obtained from the tasimelteon package insert, fda.gov, clinicaltrials.gov, briefing materials provided by Vanda Pharmaceuticals, and posters from scientific meetings. © The Author(s) 2014.

The use of mixed-integer programming for inverse treatment planning with pre-defined field segments

International Nuclear Information System (INIS)

Bednarz, Greg; Michalski, Darek; Houser, Chris; Huq, M. Saiful; Xiao Ying; Rani, Pramila Anne; Galvin, James M.

2002-01-01

Complex intensity patterns generated by traditional beamlet-based inverse treatment plans are often very difficult to deliver. In the approach presented in this work the intensity maps are controlled by pre-defining field segments to be used for dose optimization. A set of simple rules was used to define a pool of allowable delivery segments and the mixed-integer programming (MIP) method was used to optimize segment weights. The optimization problem was formulated by combining real variables describing segment weights with a set of binary variables, used to enumerate voxels in targets and critical structures. The MIP method was compared to the previously used Cimmino projection algorithm. The field segmentation approach was compared to an inverse planning system with a traditional beamlet-based beam intensity optimization. In four complex cases of oropharyngeal cancer the segmental inverse planning produced treatment plans, which competed with traditional beamlet-based IMRT plans. The mixed-integer programming provided mechanism for imposition of dose-volume constraints and allowed for identification of the optimal solution for feasible problems. Additional advantages of the segmental technique presented here are: simplified dosimetry, quality assurance and treatment delivery. (author)

Spoofing cyber attack detection in probe-based traffic monitoring systems using mixed integer linear programming

KAUST Repository

Canepa, Edward S.

2013-01-01

Traffic sensing systems rely more and more on user generated (insecure) data, which can pose a security risk whenever the data is used for traffic flow control. In this article, we propose a new formulation for detecting malicious data injection in traffic flow monitoring systems by using the underlying traffic flow model. The state of traffic is modeled by the Lighthill-Whitham- Richards traffic flow model, which is a first order scalar conservation law with concave flux function. Given a set of traffic flow data, we show that the constraints resulting from this partial differential equation are mixed integer linear inequalities for some decision variable. We use this fact to pose the problem of detecting spoofing cyber-attacks in probe-based traffic flow information systems as mixed integer linear feasibility problem. The resulting framework can be used to detect spoofing attacks in real time, or to evaluate the worst-case effects of an attack offline. A numerical implementation is performed on a cyber-attack scenario involving experimental data from the Mobile Century experiment and the Mobile Millennium system currently operational in Northern California. © 2013 IEEE.

Spoofing cyber attack detection in probe-based traffic monitoring systems using mixed integer linear programming

KAUST Repository

Canepa, Edward S.

2013-09-01

Traffic sensing systems rely more and more on user generated (insecure) data, which can pose a security risk whenever the data is used for traffic flow control. In this article, we propose a new formulation for detecting malicious data injection in traffic flow monitoring systems by using the underlying traffic flow model. The state of traffic is modeled by the Lighthill- Whitham-Richards traffic flow model, which is a first order scalar conservation law with concave flux function. Given a set of traffic flow data generated by multiple sensors of different types, we show that the constraints resulting from this partial differential equation are mixed integer linear inequalities for a specific decision variable. We use this fact to pose the problem of detecting spoofing cyber attacks in probe-based traffic flow information systems as mixed integer linear feasibility problem. The resulting framework can be used to detect spoofing attacks in real time, or to evaluate the worst-case effects of an attack offliine. A numerical implementation is performed on a cyber attack scenario involving experimental data from the Mobile Century experiment and the Mobile Millennium system currently operational in Northern California. © American Institute of Mathematical Sciences.

Comparative Survey of Mental Disorders and Personality Characteristics in Persons With Drug Dependent and Non Drug Dependent in Hamadan, Iran

Directory of Open Access Journals (Sweden)

A. Ghaleiha

2008-07-01

Full Text Available Introduction & Objective: The influence of genetic, biological, psychological, social and cultural factors on drug dependency and high rate comorbidity of this phenomenon with psychiatric disorders for example anxiety, depression and characteristics and personality disorders is emphasized. The aim of this study was the comparative investigation of mental disorders and personality traits in persons with drug dependent and non drug dependent in Hamadan city in 2001-2003 .Materials & Methods: Present research was a descriptive comparison and subjects were 100 drug dependent persons and 100 non drug dependent individuals .Case group was chosen through available sampling among persons who call on psychiatrist and control group was chosen through randomly simple sampling from general population. Measurement and diagnostic tools includes questionnaire for examining demographic characteristics, designed by researchers and MMPI, SCL90-R tests and DSM IV criteria diagnostic and also T test that was used for analyzing data.Results: Between two groups in clinical and validity scales of MMPI test expect for hypochondriasis and hysteria and scales of SCL 90-R test expect somatization and interpersonal sensitivity differences were statistically significant (P<0.05.Conclusion: We can conclude that persons with drug dependent display more signs of psychopathology and mental disorders in comparison with non drug dependent people and Major depressive disorder and personality disorder were frequent among drug dependent groups. Depression and personal disorders were frequent in non drug dependent persons too. Our results support the results of previous studies.

[Non-autistic pervasive developmental disorders: Rett syndrome, disintegrative disorder and pervasive developmental disorder not otherwise specified

NARCIS (Netherlands)

Mercadante, M.T.; Gaag, R.J. van der; Schwartzman, J.S.

2006-01-01

The category "Pervasive Developmental Disorders" includes autistic disorder, Asperger's syndrome, Rett's syndrome, childhood disintegrative disorder, and a residual category, named pervasive developmental disorder not otherwise specified. In this review, Rett's syndrome and childhood disintegrative

Assessing the relationship between eating disorder psychopathology and autistic traits in a non-clinical adult population.

Science.gov (United States)

Carton, Amelia Myri; Smith, Alastair D

2014-01-01

Previous research demonstrates a genetic and behavioural link between eating disorders and autism spectrum disorders, and a recent study (Coombs et al. in Br J Clin Psychol 50:326-338, 2011) extends this link to typical populations, showing a positive correlation between behaviours in typically developing children. The purpose of the present study was to examine whether this relationship continues beyond development, by studying the link between behaviours in a non-clinical adult population. We examined associations between performance on measures relating to autistic traits and disordered eating. Undergraduate students, equally balanced by gender and by subject studied (i.e. humanity or science), completed three tasks: to measure autistic traits, participants were administered the Embedded Figures Test (EFT) and the Autism-Spectrum Quotient (AQ). Eating disorder symptomatology was measured by the Eating Attitudes Test (Eat-26). Our data revealed a significant positive correlation between scores on the AQ and Eat-26. Multiple linear regressions showed that higher scores on the AQ were particularly associated with higher scores on the Bulimia & Food Preoccupation subscale of the Eat-26. EFT performance was positively related to behaviours associated with autism and eating disorders, although not reliably so. These data support the broader link between autistic traits and disordered eating in the non-clinical population, and demonstrate that it extends into adulthood (a time at which autistic behaviours can decrease). This work carries implications for the development of cognitive therapies for people with eating disorders.

Comparison of obese and nonobese individuals with binge eating disorder: delicate boundary between binge eating disorder and non-purging bulimia nervosa.

Science.gov (United States)

Carrard, Isabelle; Van der Linden, Martial; Golay, Alain

2012-09-01

To compare obese and nonobese individuals with binge eating disorder (BED) on demographic data, illness history, eating disorders and psychological health. This study used baseline data from a randomized controlled study on the efficacy of an online cognitive behavioural self-help treatment. Seventy-four women aged between 18 and 60 years were recruited in the community. They had to meet full or subthreshold diagnostic criteria for BED according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Forty per cent of the sample had a body mass index higher than 30 kg/m(2) . Mean age and severity of eating disorders were similar between obese and nonobese individuals. A statistically significant difference emerged regarding dietary restraint, with nonobese BED individuals exhibiting higher scores than obese BED individuals. Dietary restraint might be one of the factors explaining body mass index differences among BED individuals. This raises the question of the boundary between non-purging bulimia nervosa and BED in nonobese people. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.

Seroprevalence of Toxoplasma gondii infection among patients with non-schizophrenic neurodevelopmental disorders in Alexandria, Egypt.

Science.gov (United States)

Shehata, Amany I; Hassanein, Faika I; Abdul-Ghani, Rashad

2016-02-01

Toxoplasma gondii is an opportunistic parasite with neurotropic characteristics that can mediate neurodevelopmental disorders, including mental, behavioral and personality aspects of their hosts. Therefore, the seroprevalence of anti-Toxoplasma antibodies has been studied in patients with different neurological disorders from different localities. On searching online databases, however, we could not find published studies on the seroprevalence of anti-Toxoplasma antibodies among patients with neurodevelopmental disorders in Egypt. Therefore, the present preliminary study was conducted to determine the serological profile of T. gondii infection among patients with non-schizophrenic neurodevelopmental disorders in Alexandria, Egypt. Data and blood samples were collected from 188 patients recruited for the study from four mental rehabilitation centers in the period from July 2014 to March 2015. The overall seropositivity rates of IgM and IgG among patients were 16.5% (31/188) and 50.0% (94/188), respectively. Of the studied patients' characteristics, only age was significantly associated with anti-Toxoplasma IgG seropositivity, with older patients being about twice more likely exposed to infection. However, no statistically significant association was found with IgM. In addition, seropositivity of anti-Toxoplasma IgG, but not IgM, was significantly associated with non-schizophrenic neurodevelopmental disorders; however, neither IgG nor IgM showed a significant association with cognitive impairment as indicated by the intelligence quotient scores. Copyright © 2015 Elsevier B.V. All rights reserved.

SRTM Colored Height and Shaded Relief: Lava plateaus in Argentina

Science.gov (United States)

2001-01-01

All of the major landforms relate to volcanism and/or erosion in this Shuttle Radar Topography Mission scene of Patagonia, near La Esperanza, Argentina. The two prominent plateaus once formed a continuous surface that extended over much of this region. Younger volcanoes have grown through and atop the plateau, and one just south of this scene has sent a long, narrow flow down a stream channel (lower left). The topographic pattern shows that streams dominate the erosion processes in this arid environment even though wind is known to move substantial amounts of sediment here.Two visualization methods were combined to produce this image: shading and color coding of topographic height. The shade image was derived by computing topographic slope in the north-south direction. Northern slopes appear bright and southern slopes appear dark, as would be the case at noon at this latitude in the southern hemisphere. Color-coding is directly related to topographic height, with green at the lower elevations, rising through yellow, red, and magenta, to white at the highest elevations.Elevation data used in this image was acquired by the Shuttle Radar Topography Mission aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense, and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Earth Science Enterprise, Washington, DC.Size: 62.4 by 88.8 kilometers

Non-equilibrium statistical physics with application to disordered systems

CERN Document Server

Cáceres, Manuel Osvaldo

2017-01-01

This textbook is the result of the enhancement of several courses on non-equilibrium statistics, stochastic processes, stochastic differential equations, anomalous diffusion and disorder. The target audience includes students of physics, mathematics, biology, chemistry, and engineering at undergraduate and graduate level with a grasp of the basic elements of mathematics and physics of the fourth year of a typical undergraduate course. The little-known physical and mathematical concepts are described in sections and specific exercises throughout the text, as well as in appendices. Physical-mathematical motivation is the main driving force for the development of this text. It presents the academic topics of probability theory and stochastic processes as well as new educational aspects in the presentation of non-equilibrium statistical theory and stochastic differential equations.. In particular it discusses the problem of irreversibility in that context and the dynamics of Fokker-Planck. An introduction on fluc...

A generalised groundwater flow equation using the concept of non ...

African Journals Online (AJOL)

The classical Darcy law is generalised by regarding the water flow as a function of a non-integer order derivative of the piezometric head. This generalised law and the law of conservation of mass are then used to derive a new equation for groundwater flow. Numerical solutions of this equation for various fractional orders of ...

Combinatorial Integer Labeling Thorems on Finite Sets with an Application to Discrete Systems of Nonlinear Equations

NARCIS (Netherlands)

van der Laan, G.; Talman, A.J.J.; Yang, Z.F.

2007-01-01

Tucker's well-known combinatorial lemma states that for any given symmetric triangulation of the n-dimensional unit cube and for any integer labeling that assigns to each vertex of the triangulation a label from the set f§1;§2; ¢ ¢ ¢ ;§ng with the property that antipodal vertices on the boundary of

Infrared spectroscopy of Landau levels of graphene.

Science.gov (United States)

Jiang, Z; Henriksen, E A; Tung, L C; Wang, Y-J; Schwartz, M E; Han, M Y; Kim, P; Stormer, H L

2007-05-11

We report infrared studies of the Landau level (LL) transitions in single layer graphene. Our specimens are density tunable and show in situ half-integer quantum Hall plateaus. Infrared transmission is measured in magnetic fields up to B=18 T at selected LL fillings. Resonances between hole LLs and electron LLs, as well as resonances between hole and electron LLs, are resolved. Their transition energies are proportional to sqrt[B], and the deduced band velocity is (-)c approximately equal to 1.1 x 10(6) m/s. The lack of precise scaling between different LL transitions indicates considerable contributions of many-particle effects to the infrared transition energies.

Entanglement Properties of a Higher-Integer-Spin AKLT Model with Quantum Group Symmetry

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Chikashi Arita

2012-10-01

Full Text Available We study the entanglement properties of a higher-integer-spin Affleck-Kennedy-Lieb-Tasaki model with quantum group symmetry in the periodic boundary condition. We exactly calculate the finite size correction terms of the entanglement entropies from the double scaling limit. We also evaluate the geometric entanglement, which serves as another measure for entanglement. We find the geometric entanglement reaches its maximum at the isotropic point, and decreases with the increase of the anisotropy. This behavior is similar to that of the entanglement entropies.

Incidence and 12-month outcome of non-transient childhood conversion disorder in the U.K. and Ireland.

Science.gov (United States)

Ani, Cornelius; Reading, Richard; Lynn, Richard; Forlee, Simone; Garralda, Elena

2013-06-01

Little is known about conversion disorder in childhood. To document clinical incidence, features, management and 12-month outcome of non-transient conversion disorder in under 16-year-olds in the U.K. and Ireland. Surveillance through the British Paediatric Surveillance Unit and Child and Adolescent Psychiatry Surveillance System. In total, 204 cases (age range 7-15 years) were reported, giving a 12-month incidence of 1.30/100 000 (95% CI 1.11-1.52). The most common symptoms were motor weakness and abnormal movements. Presentation with multiple symptoms was the norm. Antecedent stressors were reported for 80.8%, most commonly bullying in school. Most children required in-patient admission with frequent medical investigations. Follow-up at 12 months was available for 147 children, when all conversion disorder symptoms were reported as improved. Most families (91%) accepted a non-medical explanation of the symptoms either fully or partially. Childhood conversion disorder represents an infrequent but significant clinical burden in the UK and Ireland.

Recent Advances in Non-invasive Brain Stimulation for Major Depressive Disorder

Directory of Open Access Journals (Sweden)

Shui Liu

2017-11-01

Full Text Available Non-invasive brain stimulation (NBS is a promising treatment for major depressive disorder (MDD, which is an affective processing disorder involving abnormal emotional processing. Many studies have shown that repetitive transcranial magnetic stimulation (rTMS and transcranial direct current stimulation (tDCS over the prefrontal cortex can play a regulatory role in affective processing. Although the clinical efficacy of NBS in MDD has been demonstrated clinically, the precise mechanism of action remains unclear. Therefore, this review article summarizes the current status of NBS methods, including rTMS and tDCS, in the treatment of MDD. The article explores possible correlations between depressive symptoms and affective processing, highlighting the relevant affective processing mechanisms. Our review provides a reference for the safety and efficacy of NBS methods in the clinical treatment of MDD.

Superradiance, disorder, and the non-Hermitian Hamiltonian in open quantum systems

Energy Technology Data Exchange (ETDEWEB)

Celardo, G. L.; Biella, A.; Giusteri, G. G.; Mattiotti, F. [Dipartimento di Matematica e Fisica and Interdisciplinary Laboratories for Advanced Materials Physics, Università Cattolica, via Musei 41, 25121 Brescia (Italy); Zhang, Y.; Kaplan, L. [Department of Physics and Engineering Physics, Tulane University, New Orleans, Louisiana 70118 (United States)

2014-10-15

We first briefly review the non-Hermitian effective Hamiltonian approach to open quantum systems and the associated phenomenon of superradiance. We next discuss the superradiance crossover in the presence of disorder and the relationship between superradiance and the localization transition. Finally, we investigate the regime of validity of the energy-independent effective Hamiltonian approximation and show that the results obtained by these methods are applicable to realistic physical systems.

Origin and diversity of an underutilized fruit tree crop, cempedak (Artocarpus integer, Moraceae).

Science.gov (United States)

Wang, Maria M H; Gardner, Elliot M; Chung, Richard C K; Chew, Ming Yee; Milan, Abd Rahman; Pereira, Joan T; Zerega, Nyree J C

2018-06-06

Underutilized crops and their wild relatives are important resources for crop improvement and food security. Cempedak [Artocarpus integer (Thunb). Merr.] is a significant crop in Malaysia but underutilized elsewhere. Here we performed molecular characterization of cempedak and its putative wild relative bangkong (Artocarpus integer (Thunb). Merr. var. silvestris Corner) to address questions regarding the origin and diversity of cempedak. Using data from 12 microsatellite loci, we assessed the genetic diversity and genetic/geographic structure for 353 cempedak and 175 bangkong accessions from Malaysia and neighboring countries and employed clonal analysis to characterize cempedak cultivars. We conducted haplotype network analyses on the trnH-psbA region in a subset of these samples. We also analyzed key vegetative characters that reportedly differentiate cempedak and bangkong. We show that cempedak and bangkong are sister taxa and distinct genetically and morphologically, but the directionality of domestication origin is unclear. Genetic diversity was generally higher in bangkong than in cempedak. We found a distinct genetic cluster for cempedak from Borneo as compared to cempedak from Peninsular Malaysia. Finally, cempedak cultivars with the same names did not always share the same genetic fingerprint. Cempedak origins are complex, with likely admixture and hybridization with bangkong, warranting further investigation. We provide a baseline of genetic diversity of cempedak and bangkong in Malaysia and found that germplasm collections in Malaysia represent diverse coverage of the four cempedak genetic clusters detected. © 2018 Botanical Society of America.

Advances in mixed-integer programming methods for chemical production scheduling.

Science.gov (United States)

Velez, Sara; Maravelias, Christos T

2014-01-01

The goal of this paper is to critically review advances in the area of chemical production scheduling over the past three decades and then present two recently proposed solution methods that have led to dramatic computational enhancements. First, we present a general framework and problem classification and discuss modeling and solution methods with an emphasis on mixed-integer programming (MIP) techniques. Second, we present two solution methods: (a) a constraint propagation algorithm that allows us to compute parameters that are then used to tighten MIP scheduling models and (b) a reformulation that introduces new variables, thus leading to effective branching. We also present computational results and an example illustrating how these methods are implemented, as well as the resulting enhancements. We close with a discussion of open research challenges and future research directions.

Screening of Hemoglobin disorder in non-endemic region

Directory of Open Access Journals (Sweden)

Shiva Raj K.C.

2017-09-01

them of their risk, and possibilities for reducing it, usually leads to a fall in births and deaths of affected children. Requirements are the same for thalassaemias and sickle-cell disorders.  To prevent and minimize the disease regular screening; in all the communities; should be conducted at least in anaemic individuals with microcytic hypochromic anaema.  Population screening is not the only useful strategy: family studies can be cost-effective.The effects of screening depend on the choices made by informed individuals. Birth prevalence of thalassaemia can fall by over 90%6,7 because most at-risk couples limit their family to two healthy children,6,7 there is very high uptake of prenatal diagnosis, and some carriers avoid risk by selecting a non-carrier partner.6,7 Available data for sickle-cell disorders shows lower use of prenatal diagnosis8 and improved survival of affected children with neonatal diagnosis.

Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study.

Science.gov (United States)

McCue, Lena M; Flick, Louise H; Twyman, Kimberly A; Xian, Hong; Conturo, Thomas E

2016-11-28

Autism spectrum disorder (ASD) is a heterogeneous disorder characterized not only by deficits in communication and social interactions but also a high rate of co-occurring disorders, including metabolic abnormalities, gastrointestinal and sleep disorders, and seizures. Seizures, when present, interfere with cognitive development and are associated with a higher mortality rate in the ASD population. To determine the relative prevalence of non-febrile seizures in children with idiopathic ASD from multiplex and simplex families compared with the unaffected siblings in a cohort of 610 children with idiopathic ASD and their 160 unaffected siblings, participating in the Autism Genetic Resource Exchange project, the secondary analysis was performed comparing the life-time prevalence of non-febrile seizures. Statistical models to account for non-independence of observations, inherent with the data from multiplex families, were used in assessing potential confounding effects of age, gender, and history of febrile seizures on odds of having non-febrile seizures. The life-time prevalence of non-febrile seizures was 8.2% among children with ASD and 2.5% among their unaffected siblings. In a logistic regression analysis that adjusted for familial clustering, children with ASD had 5.27 (95%CI: 1.51-18.35) times higher odds of having non-febrile seizures compared to their unaffected siblings. In this comparison, age, presence of gastrointestinal dysfunction, and history of febrile seizures were significantly associated with the prevalence of non-febrile seizures. Children with idiopathic ASD are significantly more likely to have non-febrile seizures than their unaffected siblings, suggesting that non-febrile seizures may be ASD-specific. Further studies are needed to determine modifiable risk factors for non-febrile seizures in ASD.

Formation of quadrupolar phase in non-Heisenberg ferromagnets with half-integer spin

International Nuclear Information System (INIS)

Fridman, Yu.A.; Kosmachev, O.A.; Spirin, D.V.

2005-01-01

Possibility of realization of quadrupolar phase in non-Heisenberg ferromagnet with magnetic ion spin 32 is studied. It is shown that such phase state exists only in ferromagnets with high value of biquadratic exchange when external magnetic field is not applied. Phase diagram of the system is built

Non-uniform approximations for sums of discrete m-dependent random variables

OpenAIRE

Vellaisamy, P.; Cekanavicius, V.

2013-01-01

Non-uniform estimates are obtained for Poisson, compound Poisson, translated Poisson, negative binomial and binomial approximations to sums of of m-dependent integer-valued random variables. Estimates for Wasserstein metric also follow easily from our results. The results are then exemplified by the approximation of Poisson binomial distribution, 2-runs and $m$-dependent $(k_1,k_2)$-events.

Group behavioral therapy for adolescents with tic-related and non-tic-related obsessive-compulsive disorder.

Science.gov (United States)

Himle, Joseph A; Fischer, Daniel J; Van Etten, Michelle L; Janeck, Amy S; Hanna, Gregory L

2003-01-01

Prior research supports the distinction between tic-related and non-tic-related obsessive-compulsive disorder (OCD) based on phenomenologic, etiologic, and neurobehavioral data. The present study examines whether response to psychosocial treatment differs in adolescents, depending on the presence of comorbid tics. Nineteen adolescents, 12-17 years of age, participated in 7-week, uncontrolled trial of group cognitive-behavioral treatment (CBT) for OCD. Eight of the patients had tic-related and eleven had non-tic-related OCD. The group CBT program included psycho-education, exposure and response prevention, cognitive strategies, and family involvement. Significant improvement was observed for all subjects on the Yale-Brown Obsessive Compulsive Scale ratings of obsessions, compulsions, and total OCD symptoms. Outcomes were similar for subjects with tic-related and non-tic-related OCD. These preliminary results suggest that the presence of comorbid tic disorders may not attenuate response to behavioral group treatment among adolescents. Copyright 2003 Wiley-Liss, Inc.

Mental Disorders in Substance Dependent Individuals as Compared to Non-Substance Dependent People in Hamadan, Iran

Directory of Open Access Journals (Sweden)

A. Heidari Pahlavian

2011-10-01

Full Text Available Introduction & Objective: There are several close links between substance dependency and mental disorders. Many people who regularly abuse drugs are also diagnosed with psychiatric disorders and vice versa. The high prevalence of this comorbidity has been documented in several studies, although most of the research has been carried out in only a few countries and the cultural validity of the data is unknown. Thus the aim of this study was the comparative investigation of mental disorders in drug dependent and non drug dependent persons in city of Hamadan.Materials & Methods: This study was a descriptive comparative research. 106 men aged 18 to 51 who sought treatment at addiction rehabilitation department of Hamadan were recruited in this study. Also 106 men in the same age range were matched with the first group. Data were collected through structured clinical interview for DSM-IV-TR and SCL 90-R questionnaire. Data were analyzed using t-test and correlation coefficient test.Results: The rate and severity of mental disorders in 9 studied Categories of disorders—phobia, anxiety, somatization, psychotism, depression, paranoid thoughts, aggression, interpersonal sensitivity and obsession-compulsion—were significantly higher among the addicts than the normal group.The level of severity was higher in depression, paranoid thoughts and interpersonal sensitivity than the other disorders. 63.5% of addicts suffered from some psychological disorders while the figures for no addicts were 28.8%. The prevalence of co-morbid psychiatric disorders varied with the pattern of addicts.Conclusion: This study showed that persons with substance dependence display more signs of psycho pathology and mental disorders in comparison with non- substance dependent people.(Sci J Hamadan Univ Med Sci 2011;18(3:22-28

Universal conductance and conductivity at critical points in integer quantum Hall systems.

Science.gov (United States)

Schweitzer, L; Markos, P

2005-12-16

The sample averaged longitudinal two-terminal conductance and the respective Kubo conductivity are calculated at quantum critical points in the integer quantum Hall regime. In the limit of large system size, both transport quantities are found to be the same within numerical uncertainty in the lowest Landau band, and , respectively. In the second-lowest Landau band, a critical conductance is obtained which indeed supports the notion of universality. However, these numbers are significantly at variance with the hitherto commonly believed value . We argue that this difference is due to the multifractal structure of critical wave functions, a property that should generically show up in the conductance at quantum critical points.

Comparison of Integer Programming (IP) Solvers for Automated Test Assembly (ATA). Research Report. ETS RR-15-05

Science.gov (United States)

Donoghue, John R.

2015-01-01

At the heart of van der Linden's approach to automated test assembly (ATA) is a linear programming/integer programming (LP/IP) problem. A variety of IP solvers are available, ranging in cost from free to hundreds of thousands of dollars. In this paper, I compare several approaches to solving the underlying IP problem. These approaches range from…

The Efficiency of Peer Teaching of Developing Non Verbal Communication to Children with Autism Spectrum Disorder (ASD)

Science.gov (United States)

Alshurman, Wael; Alsreaa, Ihsani

2015-01-01

This study aimed at identifying the efficiency of peer teaching of developing non-verbal communication to children with autism spectrum disorder (ASD). The study was carried out on a sample of (10) children with autism spectrum disorder (ASD), diagnosed according to basics and criteria adopted at Al-taif qualification center at (2013) in The…

Dispersion theory and sum rules for the non-minimum phase problem in optical spectroscopy

International Nuclear Information System (INIS)

Peiponen, Kai-Erik

2009-01-01

Dispersion relations and sum rules for integer powers of an optical response function are given in the case of the non-minimum phase problem. These relations were obtained using the concept of the Hilbert transform and Blaschke product. The theory presented in this paper is useful both in basic and applied studies of non-minimum phase functions in optics, and also other fields of physics such as high energy physics.

Sequential computation of elementary modes and minimal cut sets in genome-scale metabolic networks using alternate integer linear programming

Energy Technology Data Exchange (ETDEWEB)

Song, Hyun-Seob; Goldberg, Noam; Mahajan, Ashutosh; Ramkrishna, Doraiswami

2017-03-27

Elementary (flux) modes (EMs) have served as a valuable tool for investigating structural and functional properties of metabolic networks. Identification of the full set of EMs in genome-scale networks remains challenging due to combinatorial explosion of EMs in complex networks. It is often, however, that only a small subset of relevant EMs needs to be known, for which optimization-based sequential computation is a useful alternative. Most of the currently available methods along this line are based on the iterative use of mixed integer linear programming (MILP), the effectiveness of which significantly deteriorates as the number of iterations builds up. To alleviate the computational burden associated with the MILP implementation, we here present a novel optimization algorithm termed alternate integer linear programming (AILP). Results: Our algorithm was designed to iteratively solve a pair of integer programming (IP) and linear programming (LP) to compute EMs in a sequential manner. In each step, the IP identifies a minimal subset of reactions, the deletion of which disables all previously identified EMs. Thus, a subsequent LP solution subject to this reaction deletion constraint becomes a distinct EM. In cases where no feasible LP solution is available, IP-derived reaction deletion sets represent minimal cut sets (MCSs). Despite the additional computation of MCSs, AILP achieved significant time reduction in computing EMs by orders of magnitude. The proposed AILP algorithm not only offers a computational advantage in the EM analysis of genome-scale networks, but also improves the understanding of the linkage between EMs and MCSs.

An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders

Directory of Open Access Journals (Sweden)

Elio Scarpini

2013-10-01

Full Text Available A novel class of transcripts, long non coding RNAs (lncRNAs, has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered.

An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders

Science.gov (United States)

Fenoglio, Chiara; Ridolfi, Elisa; Galimberti, Daniela; Scarpini, Elio

2013-01-01

A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered. PMID:24129177

[Non-Suicidal Self-Injury (NSSI) and Suicidal Behavior Disorder in the DSM-5].

Science.gov (United States)

Plener, Paul L; Kapusta, Nestor D; Brunner, Romuald; Kaess, Michael

2014-11-01

Non-Suicidal Self-Injury (NSSI) and Suicidal Behavior Disorder (SBD) were included as diagnostic categories in Section 3 of the 5th edition of the Diagnostic and Statistical Manual (DSM-5) of the American Psychiatric Association (APA). Thus, these diagnostic entities were not recognized as formal clinical diagnoses, but rather for the first time clearly defined in a classificatory system to standardize further research in this field. This paper introduces both concepts and addresses the discussion about NSSI and suicidal behavior disorder based on a selective review of the literature. First studies using the new definitions are introduced. In Germany the prevalence of NSSI is estimated to lie at about 4 %, of SBD at about 9 %. It can be expected that in the future the new definitions will lead to a better comparability of study outcomes with regards to NSSI and suicidal behavior disorder.

Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of harmful effects in non-randomised studies

DEFF Research Database (Denmark)

Jakob, Storebø Ole; Nadia, Pedersen; Erica, Ramstad

2016-01-01

This is the protocol for a review and there is no abstract. The objectives are as follows:To assess the harmful effects of methylphenidate treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) in non-randomised studies.......This is the protocol for a review and there is no abstract. The objectives are as follows:To assess the harmful effects of methylphenidate treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) in non-randomised studies....

Theory for disordered phase in Heisenberg and non-Heisenberg two-dimensional S=1 ferromagnets

International Nuclear Information System (INIS)

Spirin, D.V.; Fridman, Yu.A.

2003-01-01

We apply a modification of self-consistent spin-wave theory to investigation of two-dimensional S=1 isotropic Heisenberg and non-Heisenberg ferromagnets at nonzero temperatures. We use Hubbard operators method and bosonization technique. We calculated chemical potential and found dependence of correlation length on temperature. Specific heat has Schottky-type peak and decreases at high temperatures. Disordered phase in non-Heisenberg ferromagnet is also studied. The results for such a model differ from those of Heisenberg one

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

Institute of Scientific and Technical Information of China (English)

Hong Jin; Jin-Ru Zhang; Yun Shen; Chun-Feng Liu

2017-01-01

Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism,and it may serve as a prodromal marker of neurodegenerative disease.The mechanism underlying RBD is unclear.Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease,including olfactory dysfunction,abnormal color vision,autonomic dysfunction,excessive daytime sleepiness,depression,and cognitive impairment.Parkinson's disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD.In this review,we describe the main clinical and pathogenic features of RBD,focusing on its association with other non-motor symptoms of parkinsonism.

CBT for childhood anxiety disorders: differential changes in selective attention between treatment responders and non-responders.

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Legerstee, Jeroen S; Tulen, Joke H M; Dierckx, Bram; Treffers, Philip D A; Verhulst, Frank C; Utens, Elisabeth M W J

2010-02-01

This study examined whether treatment response to stepped-care cognitive-behavioural treatment (CBT) is associated with changes in threat-related selective attention and its specific components in a large clinical sample of anxiety-disordered children. Ninety-one children with an anxiety disorder were included in the present study. Children received a standardized stepped-care CBT. Three treatment response groups were distinguished: initial responders (anxiety disorder free after phase one: child-focused CBT), secondary responders (anxiety disorder free after phase two: child-parent-focused CBT), and treatment non-responders. Treatment response was determined using a semi-structured clinical interview. Children performed a pictorial dot-probe task before and after stepped-care CBT (i.e., before phase one and after phase two CBT). Changes in selective attention to severely threatening pictures, but not to mildly threatening pictures, were significantly associated with treatment success. At pre-treatment assessment, initial responders selectively attended away from severely threatening pictures, whereas secondary responders selectively attended toward severely threatening pictures. After stepped-care CBT, initial and secondary responders did not show any selectivity in the attentional processing of severely threatening pictures. Treatment non-responders did not show any changes in selective attention due to CBT. Initial and secondary treatment responders showed a reduction of their predisposition to selectively attend away or toward severely threatening pictures, respectively. Treatment non-responders did not show any changes in selective attention. The pictorial dot-probe task can be considered a potentially valuable tool in assigning children to appropriate treatment formats as well as for monitoring changes in selective attention during the course of CBT.

Absence of even-integer ζ-function values in Euclidean physical quantities in QCD

Science.gov (United States)

Jamin, Matthias; Miravitllas, Ramon

2018-04-01

At order αs4 in perturbative quantum chromodynamics, even-integer ζ-function values are present in Euclidean physical correlation functions like the scalar quark correlation function or the scalar gluonium correlator. We demonstrate that these contributions cancel when the perturbative expansion is expressed in terms of the so-called C-scheme coupling αˆs which has recently been introduced in Ref. [1]. It is furthermore conjectured that a ζ4 term should arise in the Adler function at order αs5 in the MS ‾-scheme, and that this term is expected to disappear in the C-scheme as well.

Edit distance for marked point processes revisited: An implementation by binary integer programming

Energy Technology Data Exchange (ETDEWEB)

Hirata, Yoshito; Aihara, Kazuyuki [Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 (Japan)

2015-12-15

We implement the edit distance for marked point processes [Suzuki et al., Int. J. Bifurcation Chaos 20, 3699–3708 (2010)] as a binary integer program. Compared with the previous implementation using minimum cost perfect matching, the proposed implementation has two advantages: first, by using the proposed implementation, we can apply a wide variety of software and hardware, even spin glasses and coherent ising machines, to calculate the edit distance for marked point processes; second, the proposed implementation runs faster than the previous implementation when the difference between the numbers of events in two time windows for a marked point process is large.

The role of integer-mode rational surface on peaked profile formation in toroidal rotation velocity and ion temperature

International Nuclear Information System (INIS)

Koide, Yoshihiko; Ishida, Shin-ichi; Sakasai, Akira

1991-03-01

A particular role of integer-mode rational surfaces on the formation of peaked T i (r) and V t (r) is observed. In the case of JT-60 hot-ion regime, the plasma spontaneously changes its peaking region from the inside of q=2 surface to that of broader q=3 surface. (author)

Topologically induced fractional Hall steps in the integer quantum Hall regime of MoS 2

Science.gov (United States)

Firoz Islam, SK; Benjamin, Colin

2016-09-01

The quantum magnetotransport properties of a monolayer of molybdenum disulfide are derived using linear response theory. In particular, the effect of topological terms on longitudinal and Hall conductivity is analyzed. The Hall conductivity exhibits fractional steps in the integer quantum Hall regime. Further complete spin and valley polarization of the longitudinal conductivitity is seen in presence of these topological terms. Finally, the Shubnikov-de Hass oscillations are suppressed or enhanced contingent on the sign of these topological terms.

Cumulative childhood interpersonal trauma is associated with reduced cortical differentiation between threat and non-threat faces in posttraumatic stress disorder adults.

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Chu, Denise A; Bryant, Richard A; Gatt, Justine M; Harris, Anthony Wf

2018-03-01

Posttraumatic stress disorder and childhood trauma frequently co-occur. Both are associated with abnormal neural responses to salient emotion stimuli. As childhood trauma is a risk factor for posttraumatic stress disorder, differentiating between their neurophysiological effects is necessary to elucidate the neural pathways by which childhood trauma exposure contributes to increased posttraumatic stress disorder risks. Face-specific N170 evoked response potentials for backward-masked (non-conscious) and conscious threat (fear, angry) and non-threat (happy) faces were measured in 77 adults (18-64 years old, 64% women, 78% right-handed) symptomatic for posttraumatic stress disorder. Differences in N170 peak amplitudes for fear-versus-happy and angry-versus-happy faces at bilateral temporo-occipital (T5, T6) sites were computed. The effect of cumulative exposure to childhood interpersonal trauma, other childhood trauma, adult trauma, depression and posttraumatic stress disorder symptom severity on the N170 response was assessed using hierarchical multiple regression analyses. T5 N170 peak amplitudes for non-conscious fear-versus-happy faces were inversely related to cumulative childhood interpersonal trauma after accounting for socio-demographic, clinical symptom and other trauma factors. Posttraumatic stress disorder Avoidance was positively associated with N170 peak amplitudes for non-conscious fear-versus-happy faces, primarily due to reduced N170 responsivity to happy faces. Childhood interpersonal trauma exposure is associated with reduced discrimination between fear and happy faces, while avoidance symptom severity is associated with dampened responsivity to automatically processed happy faces in posttraumatic stress disorder adults. Results are discussed in terms of the likely contributions of impaired threat discrimination and deficient reward processing during neural processing of salient emotion stimuli, to increased risks of posttraumatic stress disorder

Existence of entire solutions of some non-linear differential-difference equations.

Science.gov (United States)

Chen, Minfeng; Gao, Zongsheng; Du, Yunfei

2017-01-01

In this paper, we investigate the admissible entire solutions of finite order of the differential-difference equations [Formula: see text] and [Formula: see text], where [Formula: see text], [Formula: see text] are two non-zero polynomials, [Formula: see text] is a polynomial and [Formula: see text]. In addition, we investigate the non-existence of entire solutions of finite order of the differential-difference equation [Formula: see text], where [Formula: see text], [Formula: see text] are two non-constant polynomials, [Formula: see text], m , n are positive integers and satisfy [Formula: see text] except for [Formula: see text], [Formula: see text].

Volumetric analysis of the hypothalamus, amygdala and hippocampus in non-suicidal and suicidal mood disorder patients--a post-mortem study.

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Bielau, Hendrik; Brisch, Ralf; Gos, Tomasz; Dobrowolny, Henrik; Baumann, Bruno; Mawrin, Christian; Kreutzmann, Peter; Bernstein, Hans-Gert; Bogerts, Bernhard; Steiner, Johann

2013-11-01

In recent years, the hypothalamus, amygdala and hippocampus have attracted increased interest with regard to the effects of stress on neurobiological systems in individuals with depression and suicidal behaviour. A large body of evidence indicates that these subcortical regions are involved in the pathogenetic mechanisms of mood disorders and suicide. The current neuroimaging techniques inadequately resolve the structural components of small and complex brain structures. In previous studies, our group was able to demonstrate a structural and neuronal pathology in mood disorders. However, the impact of suicide remains unclear. In the current study we used volumetric measurements of serial postmortem sections with combined Nissl-myelin staining to investigate the hypothalamus, amygdala and hippocampus in suicide victims with mood disorders (n = 11), non-suicidal mood disorder patients (n = 9) and control subjects (n = 23). Comparisons between the groups by using an ANCOVA showed a significant overall difference for the hypothalamus (p = 0.001) with reduced volumes in non-suicidal patients compared to suicide victims (p = 0.018) and controls (p = 0.006). To our surprise, the volumes between the suicide victims and controls did not differ significantly. For the amygdala and hippocampus no volume changes between the groups could be detected (all p values were n. s.). In conclusion our data suggest a structural hypothalamic pathology in non-suicidal mood disorder patients. The detected differences between suicidal and non-suicidal patients suggest that suicidal performances might be related to the degree of structural deficits.

The exact S -matrix for an osp(2 vertical bar 2) disordered system

International Nuclear Information System (INIS)

Bassi, Zorawar S.; LeClair, Andre

2000-01-01

We study a two-dimensional disordered system consisting of Dirac fermions coupled to a scalar potential. This model is closely related to a more general disordered system that has been introduced in conjunction with the integer quantum Hall transition. After disorder averaging, the interaction can be written as a marginal osp(2 vertical bar 2) current-current perturbation. The osp(2 vertical bar 2) current-current model in turn can be viewed as the fully renormalized version of an osp(2 vertical bar 2) (1) Toda-type system (at the marginal point). We build nonlocal charges for the Toda system satisfying the U q [osp(2 vertical bar 2) (1) ] quantum superalgebra. The corresponding quantum group symmetry is used to construct a Toda S -matrix for the vector representation. We argue that in the marginal (or rational) limit, this S -matrix gives the exact (Yangian symmetric) physical S -matrix for the fundamental 'solitons' of the osp(2 vertical bar 2) current-current model

Bond and flux-disorder effects on the superconductor-insulator transition of a honeycomb array of Josephson junctions

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Granato, Enzo

2018-05-01

We study the effects of disorder on the zero-temperature quantum phase transition of a honeycomb array of Josephson junctions in a magnetic field with an average of fo flux quantum per plaquette. Bond disorder due to spatial variations in the Josephson couplings and magnetic flux disorder due to variations in the plaquette areas are considered. The model can describe the superconductor-insulator transition in ultra-thin films with a triangular pattern of nanoholes. Path integral Monte Carlo simulations of the equivalent (2 + 1)-dimensional classical model are used to study the critical behavior and estimate the universal resistivity at the transition. The results show that bond disorder leads to a rounding of the first-order phase transition for fo = 1 / 3 to a continuous transition. For integer fo, the decrease of the critical coupling parameter with flux disorder is significantly different from that of the same model defined on a square lattice. The results are compared with recent experimental observations on nanohole thin films with geometrical disorder and external magnetic field.

Fabrication of atomic-scale gold junctions by electrochemical plating using a common medical liquid

Science.gov (United States)

Umeno, A.; Hirakawa, K.

2005-04-01

Fabrication of nanometer-separated gold junctions has been performed using "iodine tincture," a medical liquid known as a disinfectant, as an etching/deposition electrolyte. In the gold-dissolved iodine tincture, gold electrodes were grown or eroded slowly enough to form quantum point contacts in an atomic scale. The resistance evolution during the electrochemical deposition showed plateaus at integer multiples of the resistance quantum, (2e2/h)-1, at room temperature (e: the elementary charge, h: the Planck constant). Iodine tincture is a commercially available common material, which makes the fabrication process to be simple and cost effective. Moreover, in contrast to the conventional electrochemical approaches, this method is free from highly toxic cyanide compounds or extraordinarily strong acids.

Lifetime Prevalence and Correlates of Schizophrenia-Spectrum, Affective, and Other Non-affective Psychotic Disorders in the Chinese Adult Population.

Science.gov (United States)

Chang, Wing Chung; Wong, Corine Sau Man; Chen, Eric Yu Hai; Lam, Linda Chiu Wa; Chan, Wai Chi; Ng, Roger Man Kin; Hung, Se Fong; Cheung, Eric Fuk Chi; Sham, Pak Chung; Chiu, Helen Fung Kum; Lam, Ming; Lee, Edwin Ho Ming; Chiang, Tin Po; Chan, Lap Kei; Lau, Gary Kar Wai; Lee, Allen Ting Chun; Leung, Grace Tak Yu; Leung, Joey Shuk Yan; Lau, Joseph Tak Fai; van Os, Jim; Lewis, Glyn; Bebbington, Paul

2017-10-21

Lifetime prevalence of psychotic disorders varies widely across studies. Epidemiological surveys have rarely examined prevalences of specific psychotic disorders other than schizophrenia, and the majority used a single-phase design without employing clinical reappraisal interview for diagnostic verification. The current study investigated lifetime prevalence, correlates and service utilization of schizophrenia-spectrum, affective, and other non-affective psychotic disorders in a representative sample of community-dwelling Chinese adult population aged 16-75 years (N = 5719) based on a territory-wide, population-based household survey for mental disorders in Hong Kong. The survey adopted a 2-phase design comprising first-phase psychosis screening and second-phase diagnostic verification incorporating clinical information from psychiatrist-administered semi-structured interview and medical record review to ascertain DSM-IV lifetime diagnosis for psychotic disorders. Data on sociodemographics, psychosocial characteristics and service utilization were collected. Our results showed that lifetime prevalence was 2.47% for psychotic disorder overall, 1.25% for schizophrenia, 0.15% for delusional disorder, 0.38% for psychotic disorder not otherwise specified, 0.31% for bipolar disorder with psychosis, and 0.33% for depressive disorder with psychosis. Schizophrenia-spectrum disorder was associated with family history of psychosis, cigarette smoking and variables indicating socioeconomic disadvantage. Victimization experiences were significantly related to affective psychoses and other non-affective psychoses. Around 80% of participants with any psychotic disorder sought some kind of professional help for mental health problems in the past year. Using comprehensive diagnostic assessment involving interview and record data, our results indicate that approximately 2.5% of Chinese adult population had lifetime psychotic disorder which represents a major public health concern. �

A mixed-integer nonlinear programming approach to the optimal design of heat network in a polygeneration energy system

International Nuclear Information System (INIS)

Zhang, Jianyun; Liu, Pei; Zhou, Zhe; Ma, Linwei; Li, Zheng; Ni, Weidou

2014-01-01

Highlights: • Integration of heat streams with HRSG in a polygeneration system is studied. • A mixed-integer nonlinear programming model is proposed to optimize heat network. • Operating parameters and heat network configuration are optimized simultaneously. • The optimized heat network highly depends on the HRSG type and model specification. - Abstract: A large number of heat flows at various temperature and pressure levels exist in a polygeneration plant which co-produces electricity and chemical products. Integration of these external heat flows in a heat recovery steam generator (HRSG) has great potential to further enhance energy efficiency of such a plant; however, it is a challenging problem arising from the large design space of heat exchanger network. In this paper, a mixed-integer nonlinear programming model is developed for the design optimization of a HRSG with consideration of all alternative matches between the HRSG and external heat flows. This model is applied to four polygeneration cases with different HRSG types, and results indicate that the optimized heat network mainly depends on the HRSG type and the model specification

Bi-objective integer programming for RNA secondary structure prediction with pseudoknots.

Science.gov (United States)

Legendre, Audrey; Angel, Eric; Tahi, Fariza

2018-01-15

RNA structure prediction is an important field in bioinformatics, and numerous methods and tools have been proposed. Pseudoknots are specific motifs of RNA secondary structures that are difficult to predict. Almost all existing methods are based on a single model and return one solution, often missing the real structure. An alternative approach would be to combine different models and return a (small) set of solutions, maximizing its quality and diversity in order to increase the probability that it contains the real structure. We propose here an original method for predicting RNA secondary structures with pseudoknots, based on integer programming. We developed a generic bi-objective integer programming algorithm allowing to return optimal and sub-optimal solutions optimizing simultaneously two models. This algorithm was then applied to the combination of two known models of RNA secondary structure prediction, namely MEA and MFE. The resulting tool, called BiokoP, is compared with the other methods in the literature. The results show that the best solution (structure with the highest F 1 -score) is, in most cases, given by BiokoP. Moreover, the results of BiokoP are homogeneous, regardless of the pseudoknot type or the presence or not of pseudoknots. Indeed, the F 1 -scores are always higher than 70% for any number of solutions returned. The results obtained by BiokoP show that combining the MEA and the MFE models, as well as returning several optimal and several sub-optimal solutions, allow to improve the prediction of secondary structures. One perspective of our work is to combine better mono-criterion models, in particular to combine a model based on the comparative approach with the MEA and the MFE models. This leads to develop in the future a new multi-objective algorithm to combine more than two models. BiokoP is available on the EvryRNA platform: https://EvryRNA.ibisc.univ-evry.fr .

Mixed Integer Linear Programming model for Crude Palm Oil Supply Chain Planning

Science.gov (United States)

Sembiring, Pasukat; Mawengkang, Herman; Sadyadharma, Hendaru; Bu'ulolo, F.; Fajriana

2018-01-01

The production process of crude palm oil (CPO) can be defined as the milling process of raw materials, called fresh fruit bunch (FFB) into end products palm oil. The process usually through a series of steps producing and consuming intermediate products. The CPO milling industry considered in this paper does not have oil palm plantation, therefore the FFB are supplied by several public oil palm plantations. Due to the limited availability of FFB, then it is necessary to choose from which plantations would be appropriate. This paper proposes a mixed integer linear programming model the supply chain integrated problem, which include waste processing. The mathematical programming model is solved using neighborhood search approach.

Cerebral metabolism in HIV infected patients with non-cognitive disorder using single voxel magnetic resonance spectroscopy

Directory of Open Access Journals (Sweden)

Shi Qi

2015-09-01

Conclusion: HIV infection induces inflammation in basal ganglia region, frontal lobe and parietal lobe before non-cognitive disorder occurs after HIV infection. However, the basal ganga region sees more neurons loss.

Prevalence of inter-hemispheric asymetry in children and adolescents with interdisciplinary diagnosis of non-verbal learning disorder.

Science.gov (United States)

Wajnsztejn, Alessandra Bernardes Caturani; Bianco, Bianca; Barbosa, Caio Parente

2016-01-01

To describe clinical and epidemiological features of children and adolescents with interdisciplinary diagnosis of non-verbal learning disorder and to investigate the prevalence of inter-hemispheric asymmetry in this population group. Cross-sectional study including children and adolescents referred for interdisciplinary assessment with learning difficulty complaints, who were given an interdisciplinary diagnosis of non-verbal learning disorder. The following variables were included in the analysis: sex-related prevalence, educational system, initial presumptive diagnoses and respective prevalence, overall non-verbal learning disorder prevalence, prevalence according to school year, age range at the time of assessment, major family complaints, presence of inter-hemispheric asymmetry, arithmetic deficits, visuoconstruction impairments and major signs and symptoms of non-verbal learning disorder. Out of 810 medical records analyzed, 14 were from individuals who met the diagnostic criteria for non-verbal learning disorder, including the presence of inter-hemispheric asymmetry. Of these 14 patients, 8 were male. The high prevalence of inter-hemispheric asymmetry suggests this parameter can be used to predict or support the diagnosis of non-verbal learning disorder. Descrever as características clínicas e epidemiológicas de crianças e adolescentes com transtorno de aprendizagem não verbal, e investigar a prevalência de assimetria inter-hemisférica neste grupo populacional. Estudo transversal que incluiu crianças e adolescentes encaminhados para uma avaliação interdisciplinar, com queixas de dificuldades de aprendizagem e que receberam diagnóstico interdisciplinar de transtorno de aprendizagem não verbal. As variáveis avaliadas foram prevalência por sexo, sistema de ensino, hipóteses diagnósticas iniciais e respectivas prevalências, prevalência de condições em relação à amostra total, prevalência geral do transtorno de aprendizagem não verbal

MRI Findings in 77 Children with Non-Syndromic Autistic Disorder

Science.gov (United States)

Boddaert, Nathalie; Zilbovicius, Mônica; Philipe, Anne; Robel, Laurence; Bourgeois, Marie; Barthélemy, Catherine; Seidenwurm, David; Meresse, Isabelle; Laurier, Laurence; Desguerre, Isabelle; Bahi-Buisson, Nadia; Brunelle, Francis; Munnich, Arnold; Samson, Yves; Mouren, Marie-Christine; Chabane, Nadia

2009-01-01

Background The clinical relevance of MR scanning in children with autism is still an open question and must be considered in light of the evolution of this technology. MRI was judged to be of insufficient value to be included in the standard clinical evaluation of autism according to the guidelines of the American Academy of Neurology and Child Neurology Society in 2000 [1]. However, this statement was based on results obtained from small samples of patients and, more importantly, included mostly insufficient MRI sequences. Our main objective was to evaluate the prevalence of brain abnormalities in a large group of children with a non-syndromic autistic disorder (AD) using T1, T2 and FLAIR MRI sequences. Methodology MRI inspection of 77 children and adolescents with non-syndromic AD (mean age 7.4±3.6) was performed. All met the DSM-IV and ADI –R criteria for autism. Based on recommended clinical and biological screenings, we excluded patients with infectious, metabolic or genetic diseases, seizures or any other neurological symptoms. Identical MRI inspections of 77 children (mean age 7.0±4.2) without AD, developmental or neurological disorders were also performed. All MRIs were acquired with a 1.5-T Signa GE (3-D T1-FSPGR, T2, FLAIR coronal and axial sequences). Two neuroradiologists independently inspected cortical and sub-cortical regions. MRIs were reported to be normal, abnormal or uninterpretable. Principal Findings MRIs were judged as uninterpretable in 10% (8/77) of the cases. In 48% of the children (33/69 patients), abnormalities were reported. Three predominant abnormalities were observed, including white matter signal abnormalities (19/69), major dilated Virchow–Robin spaces (12/69) and temporal lobe abnormalities (20/69). In all, 52% of the MRIs were interpreted as normal (36/69 patients). Conclusions An unexpectedly high rate of MRI abnormalities was found in the first large series of clinical MRI investigations in non-syndromic autism. These

Nearly Quadratic n-Derivations on Non-Archimedean Banach Algebras

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Madjid Eshaghi Gordji

2012-01-01

Full Text Available Let n>1 be an integer, let A be an algebra, and X be an A-module. A quadratic function D:A→X is called a quadratic n-derivation if D(∏i=1nai=D(a1a22⋯an2+a12D(a2a32⋯an2+⋯+a12a22⋯an−12D(an for all a1,...,an∈A. We investigate the Hyers-Ulam stability of quadratic n-derivations from non-Archimedean Banach algebras into non-Archimedean Banach modules by using the Banach fixed point theorem.

Musculoskeletal disorders associated with HIV infection and AIDS. Part II: Non-infectious musculoskeletal conditions

International Nuclear Information System (INIS)

Tehranzadeh, Jamshid; Ter-Oganesyan, Ramon R.; Steinbach, Lynne S.

2004-01-01

This section of a two-part series on musculoskeletal disorders associated with HIV infection and AIDS reviews the non-infectious musculoskeletal conditions. In the first part, the infectious conditions were reviewed. The non-infectious conditions include polymyositis, drug-induced myopathy, myositis ossificans, adhesive capsulitis, avascular necrosis, bone marrow abnormalities, and hypertrophic osteoarthropathy. Inflammatory and reactive arthropathies are more prevalent in HIV-positive individuals, and a separate section is dedicated to these conditions, including Reiter's syndrome, psoriatic arthritis, HIV-associated arthritis, painful articular syndrome, and acute symmetric polyarthritis. Lastly, we include a discussion of HIV-related neoplastic processes that affect the musculoskeletal system, namely Kaposi's sarcoma and non-Hodgkin's lymphoma. (orig.)

Oral Mucosal Disorders in Pregnant versus Non-Pregnant Women

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Fahimeh Rezazadeh

2014-12-01

Full Text Available The effects of pregnancy on the Oral Mucosa Disorder (OMD have been sporadically documented in some developed countries. Less known is the status of OMD during pregnancy in less developed/developing countries. Iran is no exception. This study assesses the prevalence of OMD in 200 pregnant women and compares the findings with the findings from a 200 non-pregnant woman of similar age distribution in Iran. The participants had been referred to a clinic to receive reproductive age-related services. Participants suffering from systemic chronic diseases, those on medications/drugs, smokers, needing biopsies, and those with urgent Oral Mucosal Lesion (OML treatments were excluded from the study. Oral mucosal of all 400 participants were examined. The participants’ age ranges were from 17 to 47; with the average age of 33.14 for one group; and 30.23 for the other group. Both groups had the same level of formal education. Out of 400 examined women; 62 had lesions, including 47 pregnant (23.5%; and 15 non-pregnant (7.5% women. This result shows that the OMD rate of occurrence was significantly higher among the pregnant women. Higher OML prevalence in pregnant women, as compared to the non-pregnant women, indicates the importance of timely oral examination of pregnant women and subsequent treatment plans for them.

Personality Disorders in Obsessive-Compulsive Disorder: A Comparative Study versus Other Anxiety Disorders

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Josep Pena-Garijo

2013-01-01

Full Text Available Objective. The purpose of this paper is to provide evidence for the relationship between personality disorders (PDs, obsessive compulsive disorder (OCD, and other anxiety disorders different from OCD (non-OCD symptomatology. Method. The sample consisted of a group of 122 individuals divided into three groups (41 OCD; 40 non-OCD, and 41 controls matched by sex, age, and educational level. All the individuals answered the IPDE questionnaire and were evaluated by means of the SCID-I and SCID-II interviews. Results. Patients with OCD and non-OCD present a higher presence of PD. There was an increase in cluster C diagnoses in both groups, with no statistically significant differences between them. Conclusions. Presenting anxiety disorder seems to cause a specific vulnerability for PD. Most of the PDs that were presented belonged to cluster C. Obsessive Compulsive Personality Disorder (OCPD is the most common among OCD. However, it does not occur more frequently among OCD patients than among other anxious patients, which does not confirm the continuum between obsessive personality and OCD. Implications for categorical and dimensional diagnoses are discussed.

Personality Disorders in Obsessive-Compulsive Disorder: A Comparative Study versus Other Anxiety Disorders

Science.gov (United States)

Pena-Garijo, Josep; Edo Villamón, Silvia; Ruipérez, M. Ángeles

2013-01-01

Objective. The purpose of this paper is to provide evidence for the relationship between personality disorders (PDs), obsessive compulsive disorder (OCD), and other anxiety disorders different from OCD (non-OCD) symptomatology. Method. The sample consisted of a group of 122 individuals divided into three groups (41 OCD; 40 non-OCD, and 41 controls) matched by sex, age, and educational level. All the individuals answered the IPDE questionnaire and were evaluated by means of the SCID-I and SCID-II interviews. Results. Patients with OCD and non-OCD present a higher presence of PD. There was an increase in cluster C diagnoses in both groups, with no statistically significant differences between them. Conclusions. Presenting anxiety disorder seems to cause a specific vulnerability for PD. Most of the PDs that were presented belonged to cluster C. Obsessive Compulsive Personality Disorder (OCPD) is the most common among OCD. However, it does not occur more frequently among OCD patients than among other anxious patients, which does not confirm the continuum between obsessive personality and OCD. Implications for categorical and dimensional diagnoses are discussed. PMID:24453917

Assessing the role of impulsivity in smoking & non-smoking disordered gamblers.

Science.gov (United States)

Boothby, Célina A; Kim, Hyoun S; Romanow, Nicole K; Hodgins, David C; McGrath, Daniel S

2017-07-01

Co-morbidity with other addictive behaviors is common in disordered gambling (DG). In particular, tobacco dependence has been found to be among the most prevalent disorders co-morbid with DG. While the extant literature has firmly established the co-occurrence of DG and smoking, there is a paucity of research examining factors that differentiate DGs who smoke from those who do not. To address this empirical gap, the current study tested whether dimensions of trait impulsivity as measured by the UPPS-P Impulsive Behavior Scale (positive urgency, negative urgency, lack of premeditation, lack of perseverance, and sensation seeking), discriminated between non-DGs and DGs based on their present smoking status: non-smoker, occasional smoker, and daily smoker. To this end, 564 community gamblers were recruited through a crowdsourcing platform (Amazon's Mechanical Turk) and completed an online survey, assessing problem gambling severity, tobacco use, and trait impulsivity. MANOVA analyses revealed significant main effects for both gambling severity and smoking status groups. Importantly, a significant gambling by smoking interaction was also found. Pairwise comparisons revealed that DGs who were daily smokers scored higher on negative urgency than those who smoked occasionally or not all. Furthermore, among non-DGs, smoking status failed to discriminate between mean scores on negative urgency. No other significant interaction effects were found for the remaining UPPS-P impulsivity facets. Results suggest that individual components of trait impulsivity, and more specifically negative urgency, successfully differentiate DGs who do not smoke, or just smoke occasionally, from DGs who smoke daily. These findings suggest that the degree of trait impulsivity may potentially distinguish between DGs and DGs who are dually addicted to other substances such as tobacco. Copyright © 2017 Elsevier Ltd. All rights reserved.

DEGRO guidelines for the radiotherapy of non-malignant disorders. Part II: Painful degenerative skeletal disorders

International Nuclear Information System (INIS)

Ott, Oliver J.; Niewald, Marcus; Weitmann, Hajo-Dirk; Jacob, Ingrid; Adamietz, Irenaeus A.; Schaefer, Ulrich; Keilholz, Ludwig; Heyd, Reinhard; Muecke, Ralph

2015-01-01

The purpose of this article is to summarize the updated DEGRO consensus S2e guideline recommendations for the treatment of benign painful degenerative skeletal disorders with low-dose radiotherapy. This overview reports on the role of low-dose radiotherapy in the treatment of enthesiopathies (shoulder syndrome, trochanteric bursitis, plantar fasciitis, and elbow syndrome) and painful arthrosis (knee, hip, hand, and finger joints). The most relevant aspects of the DEGRO S2e Consensus Guideline Radiation Therapy of Benign Diseases 2014 regarding diagnostics, treatment decision, dose prescription as well as performance of radiotherapy and results are summarized. For all indications mentioned above, retrospective and some prospective analyses have shown remarkable effects in terms of pain relief. Nevertheless, the Level of Evidence (LoE) and the Grade of Recommendation (GR) vary: LoE 1b-4 and GR A-C. Low-dose radiotherapy for painful degenerative skeletal disorders is effective in the majority of the patients and therefore it may be a reasonable therapeutic alternative when simple and non-invasive methods have been used without persistent success. For all discussed entities, single fraction doses of 0.5-1.0 Gy and total doses of 3.0-6.0 Gy/series applied with 2-3 fractions per week are recommended. (orig.) [de

Neural Mechanisms of Encoding Social and Non-Social Context Information in Autism Spectrum Disorder

Science.gov (United States)

Greimel, Ellen; Nehrkorn, Barbara; Fink, Gereon R.; Kukolja, Juraj; Kohls, Gregor; Muller, Kristin; Piefke, Martina; Kamp-Becker, Inge; Remschmidt, Helmut; Herpertz-Dahlmann, Beate; Konrad, Kerstin; Schulte-Ruther, Martin

2012-01-01

Individuals with autism spectrum disorder (ASD) often fail to attach context to their memories and are specifically impaired in processing social aspects of contextual information. The aim of the present study was to investigate the modulatory influence of social vs. non-social context on neural mechanisms during encoding in ASD. Using…

Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study.

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Garbazza, Corrado; Bromundt, Vivien; Eckert, Anne; Brunner, Daniel P; Meier, Fides; Hackethal, Sandra; Cajochen, Christian

2016-01-01

The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and a circadian process C, which determines the timing of sleep in a ~24-h rhythm in accordance to the external light-dark (LD) cycle. While both individual processes are fairly well characterized, the exact nature of their interaction remains unclear. The circadian rhythm is generated by the suprachiasmatic nucleus ("master clock") of the anterior hypothalamus, through cell-autonomous feedback loops of DNA transcription and translation. While the phase length (tau) of the cycle is relatively stable and genetically determined, the phase of the clock is reset by external stimuli ("zeitgebers"), the most important being the LD cycle. Misalignments of the internal rhythm with the LD cycle can lead to various somatic complaints and to the development of circadian rhythm sleep disorders (CRSD). Non-24-hour sleep-wake disorders (N24HSWD) is a CRSD affecting up to 50% of totally blind patients and characterized by the inability to maintain a stable entrainment of the typically long circadian rhythm (tau > 24.5 h) to the LD cycle. The disease is rare in sighted individuals and the pathophysiology less well understood. Here, we present the case of a 40-year-old sighted male, who developed a misalignment of the internal clock with the external LD cycle following the treatment for Hodgkin's lymphoma (ABVD regimen, four cycles and AVD regimen, four cycles). A thorough clinical assessment, including actigraphy, melatonin profiles and polysomnography led to the diagnosis of non-24-hour sleep-wake disorders (N24HSWD) with a free-running rhythm of tau = 25.27 h. A therapeutic intervention with bright light therapy (30 min, 10,000 lux) in the morning and melatonin administration (0.5-0.75 mg) in the evening failed to entrain the free-running rhythm, although a longer treatment duration and more intense therapy might have

[Non-structural abnormalities of CNS function resulting in coincidence of endocrinopathies, epilepsy and psychoneurologic disorders in children and adolescents].

Science.gov (United States)

Starzyk, Jerzy; Pituch-Noworolska, Anna; Pietrzyk, Jacek A; Urbanik, Andrzej; Kroczka, Sławomir; Drozdz, Ryszard; Wójcik, Małgorzata

2010-01-01

In the population of children and adolescents, epilepsy affects approximately 1% of cases, nonepileptic seizures are seen in approximately 3%, and endocrine disorders are several times more common. For this reason, coincidence of endocrine disorders and epilepsy and psychoneurologic disorders is frequent. Much less common are structural abnormalities (tumors, developmental abnormalities), and especially non-structural CNS abnormalities, resulting in coincidence of both disorders. There are no reports available in the literature that would address the problem. 1) Assessment of the frequency of coincidental epilepsy and endocrine disorders in patients without structural CSN abnormalities treated as outpatients and inpatients of Department of Endocrinology University Children's Hospital of Krakow. 2) Presentation of diagnostic and therapeutic difficulties in these patients, and 3) An attempt at defining the common etiology of both disorders. On the basis of ICD code patients with coincidance of endocrine disorders, epilepsy and psychoneurologic disorders were selected from several thousands of children treated between 2000 and 2009 in Pediatric Endocrinology Department. The neurologic disorders were diagnosed and treated in Chair and Department of Children's and Adolescents Neurology or in another pediatric neurology center. Various forms of epilepsy (symptomatic or idiopathic) and other psychoneurological disorders (disorders of behavior and emotions, obsession-compulsion syndromes, stereotypias, aggression, autoaggression, or hypothalamic obesity) coincident with one or more endocrine disorders, such as growth disorders, disorders of pubertal development, obesity, thyroid diseases, adrenal diseases, hyperprolactinemia, hypoparathyroidism and ion metabolism disorders were diagnosed in 49 patients. The group included: i) children after cranial irradiation and chemotherapy due to medulloblastoma (3 patients), oligodenroglioma (1 patient), ependymoma (1 patient), optic

Real-space mapping of a disordered two-dimensional electron system in the quantum Hall regime

International Nuclear Information System (INIS)

Hashimoto, K; Hirayama, Y; Wiebe, J; Wiesendanger, R; Inaoka, T; Morgenstern, M

2011-01-01

By using scanning tunnelling spectroscopy, we study the influence of potential disorder on an adsorbate-induced two-dimensional electron system in the integer quantum Hall regime. The real-space imaged local density of states exhibits transition from localized drift states encircling the potential minima to another type of localized drift states encircling the potential maxima. While the former states show regular round shapes, the latter have irregular-shaped patterns. This difference is induced by different sources for the potential minima and maxima, i.e., substrate donors and an inhomogeneous distribution of the adsorbates, respectively.

Emotional intelligence and non-social cognition in schizophrenia and bipolar I disorder.

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Frajo-Apor, B; Kemmler, G; Pardeller, S; Plass, T; Mühlbacher, M; Welte, A-S; Fleischhacker, W W; Hofer, A

2017-01-01

The different patterns of Emotional Intelligence (EI) deficits in schizophrenia and bipolar I disorder are are not yet well understood. This study compares EI levels among these groups and highlights the potential impact of non-social cognition on EI. Fifty-eight schizophrenia and 60 bipolar outpatients were investigated using the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) and the Brief Assessment of Cognition in Schizophrenia (BACS). Analyses of covariance were performed with adjustment for the BACS composite score. Compared to bipolar subjects, schizophrenia patients showed significantly lower levels in both EI and non-social cognition. After adjustment for the BACS composite score, the difference in EI was lost. The mediation analysis revealed that differences between schizophrenia and bipolar patients in strategic EI are almost fully attributable to the mediating effect of non-social cognition. Our findings suggest that in both schizophrenia and bipolar patients EI is strongly influenced by non-social cognitive functioning. This has to be taken into account when interpreting MSCEIT data in comparative studies in serious mental illness and emphasizes the importance of cognitive remediation.

Childhood Familial Environment, Maltreatment and Borderline Personality Disorder Symptoms in a Non-Clinical Sample: A Cognitive Behavioural Perspective

Science.gov (United States)

Carr, Steven; Francis, Andrew

2009-01-01

The present study sought to determine if cognitive beliefs and schemas mediated the relationship between retrospectively reported childhood events and adult borderline personality disorder (BPD) symptoms in a non-clinical sample. One hundred and seventy-eight non-clinical participants completed questionnaires measuring BPD symptoms, core beliefs,…

The contribution of work and non-work stressors to common mental disorders in the 2007 Adult Psychiatric Morbidity Survey.

Science.gov (United States)

Clark, C; Pike, C; McManus, S; Harris, J; Bebbington, P; Brugha, T; Jenkins, R; Meltzer, H; Weich, S; Stansfeld, S

2012-04-01

Evidence for an effect of work stressors on common mental disorders (CMD) has increased over the past decade. However, studies have not considered whether the effects of work stressors on CMD remain after taking co-occurring non-work stressors into account. Data were from the 2007 Adult Psychiatric Morbidity Survey, a national population survey of participants 6 years living in private households in England. This paper analyses data from employed working age participants (N=3383: 1804 males; 1579 females). ICD-10 diagnoses for depressive episode, generalized anxiety disorder, obsessive compulsive disorder, agoraphobia, social phobia, panic or mixed anxiety and depression in the past week were derived using a structured diagnostic interview. Questionnaires assessed self-reported work stressors and non-work stressors. The effects of work stressors on CMD were not explained by co-existing non-work stressors. We found independent effects of work and non-work stressors on CMD. Job stress, whether conceptualized as job strain or effort-reward imbalance, together with lower levels of social support at work, recent stressful life events, domestic violence, caring responsibilities, lower levels of non-work social support, debt and poor housing quality were all independently associated with CMD. Social support at home and debt did not influence the effect of work stressors on CMD. Non-work stressors do not appear to make people more susceptible to work stressors; both contribute to CMD. Tackling workplace stress is likely to benefit employee psychological health even if the employee's home life is stressful but interventions incorporating non-work stressors may also be effective.

CSF 5-HIAA and DST non-suppression--orthogonal biologic risk factors for suicide in male mood disorder inpatients.

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Jokinen, Jussi; Nordström, Anna-Lena; Nordström, Peter

2009-01-30

Two biomarkers of suicide risk; non-suppression in the dexamethasone suppression test (DST) and low 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been reported to be predictors of suicide in mood disorders. The interrelation of the two systems seems to be different in suicide attempters compared with depressed inpatients who have not made a suicide attempt, indicating that the two biomarkers may be seen as independent. This investigation examined the interrelation of low CSF 5-HIAA and DST non-suppression in suicide victims with mood disorder. Fifty-eight mood disorder inpatients not receiving any treatment with antidepressants underwent lumbar puncture and the DST. Plasma cortisol levels at 8:00 a.m., 4:00 p.m. and 11:00 p.m. were analysed in relation to CSF 5-HIAA. All patients were followed up for causes of death and suicides were verified with death certificates. During follow-up (mean 21 years), 11 (19%) patients had committed suicide. In male suicide victims (n=6), the serum cortisol level at 4:00 p.m. showed a significant positive correlation with CSF 5-HIAA. Low CSF 5-HIAA predicted all early suicides (within 1 year), whereas all males who committed suicide after 1 year were DST non-suppressors. In female suicide victims (n=5), the post-DST serum cortisol did not correlate with CSF 5-HIAA. Low CSF 5-HIAA and DST non-suppression are orthogonal biologic risk factors for suicide in male mood disorder inpatients. CSF 5-HIAA is associated with short-term suicide risk; dysregulation of the hypothalamic-pituitary-adrenal axis seems to be a long-term suicide predictor.

Integer Representations towards Efficient Counting in the Bit Probe Model

DEFF Research Database (Denmark)

Brodal, Gerth Stølting; Greve, Mark; Pandey, Vineet

2011-01-01

Abstract We consider the problem of representing numbers in close to optimal space and supporting increment, decrement, addition and subtraction operations efficiently. We study the problem in the bit probe model and analyse the number of bits read and written to perform the operations, both...... in the worst-case and in the average-case. A counter is space-optimal if it represents any number in the range [0,...,2 n  − 1] using exactly n bits. We provide a space-optimal counter which supports increment and decrement operations by reading at most n − 1 bits and writing at most 3 bits in the worst......-case. To the best of our knowledge, this is the first such representation which supports these operations by always reading strictly less than n bits. For redundant counters where we only need to represent numbers in the range [0,...,L] for some integer L bits, we define the efficiency...

An Integer Programming Approach to Solving Tantrix on Fixed Boards

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Yushi Uno

2012-03-01

Full Text Available Tantrix (Tantrix R ⃝ is a registered trademark of Colour of Strategy Ltd. in New Zealand, and of TANTRIX JAPAN in Japan, respectively, under the license of M. McManaway, the inventor. is a puzzle to make a loop by connecting lines drawn on hexagonal tiles, and the objective of this research is to solve it by a computer. For this purpose, we first give a problem setting of solving Tantrix as making a loop on a given fixed board. We then formulate it as an integer program by describing the rules of Tantrix as its constraints, and solve it by a mathematical programming solver to have a solution. As a result, we establish a formulation that can solve Tantrix of moderate size, and even when the solutions are invalid only by elementary constraints, we achieved it by introducing additional constraints and re-solve it. By this approach we succeeded to solve Tantrix of size up to 60.

Musculoskeletal disorders associated with HIV infection and AIDS. Part II: Non-infectious musculoskeletal conditions

Energy Technology Data Exchange (ETDEWEB)

Tehranzadeh, Jamshid [Department of Radiological Sciences, University of California, Irvine, CA (United States); Department of Radiological Sciences, Orange, CA (United States); Ter-Oganesyan, Ramon R. [College of Medicine, University of California, Irvine, CA (United States); Steinbach, Lynne S. [Department of Radiological Sciences, University of California, San Francisco (United States)

2004-06-01

This section of a two-part series on musculoskeletal disorders associated with HIV infection and AIDS reviews the non-infectious musculoskeletal conditions. In the first part, the infectious conditions were reviewed. The non-infectious conditions include polymyositis, drug-induced myopathy, myositis ossificans, adhesive capsulitis, avascular necrosis, bone marrow abnormalities, and hypertrophic osteoarthropathy. Inflammatory and reactive arthropathies are more prevalent in HIV-positive individuals, and a separate section is dedicated to these conditions, including Reiter's syndrome, psoriatic arthritis, HIV-associated arthritis, painful articular syndrome, and acute symmetric polyarthritis. Lastly, we include a discussion of HIV-related neoplastic processes that affect the musculoskeletal system, namely Kaposi's sarcoma and non-Hodgkin's lymphoma. (orig.)

On the group of substitutions of formal power series with integer coefficients

International Nuclear Information System (INIS)

Babenko, I K; Bogatyi, S A

2008-01-01

We study certain properties of the group J(Z) of substitutions of formal power series in one variable with integer coefficients. We show that J(Z), regarded as a topological group, has four generators and cannot be generated by fewer elements. In particular, we show that the one-dimensional continuous homology of J(Z) is isomorphic to Z oplus Z oplus Z 2 oplus Z 2 . We study various topological and geometric properties of the coset space J(R)/J(Z). We compute the real cohomology H-tilde*(J(Z);R) with uniformly locally constant supports and show that it is naturally isomorphic to the cohomology of the nilpotent part of the Lie algebra of formal vector fields on the line

Diagnostic distribution of non-traumatic upper limb disorders

DEFF Research Database (Denmark)

Laursen, Lise H; Sjøgaard, Gisela; Hagert, C G

2007-01-01

BACKGROUND: Upper limb disorders (ULDs) are common, and so are the difficulties in specific diagnoses of these disorders. Prior studies have shed light on the nerves in the diagnostic approach beside disorders related to muscles, tendons and joints (MCDs). OBJECTIVE: The study aimed to compare th...

Sequential computation of elementary modes and minimal cut sets in genome-scale metabolic networks using alternate integer linear programming.

Science.gov (United States)

Song, Hyun-Seob; Goldberg, Noam; Mahajan, Ashutosh; Ramkrishna, Doraiswami

2017-08-01

Elementary (flux) modes (EMs) have served as a valuable tool for investigating structural and functional properties of metabolic networks. Identification of the full set of EMs in genome-scale networks remains challenging due to combinatorial explosion of EMs in complex networks. It is often, however, that only a small subset of relevant EMs needs to be known, for which optimization-based sequential computation is a useful alternative. Most of the currently available methods along this line are based on the iterative use of mixed integer linear programming (MILP), the effectiveness of which significantly deteriorates as the number of iterations builds up. To alleviate the computational burden associated with the MILP implementation, we here present a novel optimization algorithm termed alternate integer linear programming (AILP). Our algorithm was designed to iteratively solve a pair of integer programming (IP) and linear programming (LP) to compute EMs in a sequential manner. In each step, the IP identifies a minimal subset of reactions, the deletion of which disables all previously identified EMs. Thus, a subsequent LP solution subject to this reaction deletion constraint becomes a distinct EM. In cases where no feasible LP solution is available, IP-derived reaction deletion sets represent minimal cut sets (MCSs). Despite the additional computation of MCSs, AILP achieved significant time reduction in computing EMs by orders of magnitude. The proposed AILP algorithm not only offers a computational advantage in the EM analysis of genome-scale networks, but also improves the understanding of the linkage between EMs and MCSs. The software is implemented in Matlab, and is provided as supplementary information . hyunseob.song@pnnl.gov. Supplementary data are available at Bioinformatics online. Published by Oxford University Press 2017. This work is written by US Government employees and are in the public domain in the US.

Integer programming and combinatorial optimization : 15th international conference, IPCO 2011, New York NY, USA, June 15-17, 2011 : proceedings

NARCIS (Netherlands)

Günlük, O.; Woeginger, G.J.

2011-01-01

This volume contains the 33 papers presented at IPCO 2011, the 15th Conference on Integer Programming and Combinatorial Optimization, held during June 15–17, 2011 at the IBM T.J. Watson Research Center in New York, USA. IPCO conferences are sponsored by the Mathematical Optimization Society. The

Integer batch scheduling problems for a single-machine with simultaneous effect of learning and forgetting to minimize total actual flow time

Directory of Open Access Journals (Sweden)

Rinto Yusriski

2015-09-01

Full Text Available This research discusses an integer batch scheduling problems for a single-machine with position-dependent batch processing time due to the simultaneous effect of learning and forgetting. The decision variables are the number of batches, batch sizes, and the sequence of the resulting batches. The objective is to minimize total actual flow time, defined as total interval time between the arrival times of parts in all respective batches and their common due date. There are two proposed algorithms to solve the problems. The first is developed by using the Integer Composition method, and it produces an optimal solution. Since the problems can be solved by the first algorithm in a worst-case time complexity O(n2n-1, this research proposes the second algorithm. It is a heuristic algorithm based on the Lagrange Relaxation method. Numerical experiments show that the heuristic algorithm gives outstanding results.

Panic disorder phenomenology in urban self-identified Caucasian-Non-Hispanics and Caucasian-Hispanics.

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Hollifield, Michael; Finley, M Rosina; Skipper, Betty

2003-01-01

The epidemiology of panic disorder is well known, but data about some phenomenological aspects are sparse. The symptom criteria for panic disorder were developed largely from rational expert consensus methods and not from empirical research. This fact calls attention to the construct validity of the panic disorder diagnosis, which may affect accuracy of epidemiological findings. Seventy self-identified Non-Hispanic-Caucasian (Anglo) and Hispanic-Caucasian (Hispanic) people who were diagnosed with DSM-III-R panic disorder with or without agoraphobia were invited to complete a Panic Phenomenological Questionnaire (PPQ), which was constructed for this study from the Hamilton Anxiety Scale Items and The DSM-III-R panic symptoms. Fifty (71%) subjects agreed to participate, and there was no response bias detected. Seven symptoms on the PPQ that are not in the DSM-IV diagnostic criteria were reported to occur with a high prevalence in this study. Furthermore, many symptoms that occurred with a high frequency and were reported to be experienced as severe are also not included in current nosology. A few of the DSM-IV criterion symptoms occurred with low prevalence, frequency, and severity. Cognitive symptoms were reported to occur with higher frequency and severity during attacks than autonomic or other symptoms. There were modest differences between ethnic groups with regard to panic attack phenomena. Further research using multiple empirical methods aimed at improving the content validity of the panic disorder diagnosis is warranted. This includes utilizing consistent methods to collect data that will allow for rational decisions about how to construct valid panic disorder criteria across cultures. Copyright 2003 Wiley-Liss, Inc.

Equilibrium phases of dipolar lattice bosons in the presence of random diagonal disorder

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Zhang, C.; Safavi-Naini, A.; Capogrosso-Sansone, B.

2018-01-01

Ultracold gases offer an unprecedented opportunity to engineer disorder and interactions in a controlled manner. In an effort to understand the interplay between disorder, dipolar interactions, and quantum degeneracy, we study two-dimensional hard-core dipolar lattice bosons in the presence of on-site bound disorder. Our results are based on large-scale path-integral quantum Monte Carlo simulations by the worm algorithm. We study the ground-state phase diagram at a fixed half-integer filling factor for which the clean system is either a superfluid at a lower dipolar interaction strength or a checkerboard solid at a larger dipolar interaction strength. We find that, even for weak dipolar interactions, superfluidity is destroyed in favor of a Bose glass at a relatively low disorder strength. Interestingly, in the presence of disorder, superfluidity persists for values of the dipolar interaction strength for which the clean system is a checkerboard solid. At a fixed disorder strength, as the dipolar interaction is increased, superfluidity is destroyed in favor of a Bose glass. As the interaction is further increased, the system eventually develops extended checkerboard patterns in the density distribution. Due to the presence of disorder, though, grain boundaries and defects, responsible for a finite residual compressibility, are present in the density distribution. Finally, we study the robustness of the superfluid phase against thermal fluctuations.

Clinical effects of non-ablative and ablative fractional lasers on various hair disorders: a case series of 17 patients.

Science.gov (United States)

Cho, Suhyun; Choi, Min Ju; Zheng, Zhenlong; Goo, Boncheol; Kim, Do-Young; Cho, Sung Bin

2013-04-01

Both ablative and non-ablative fractional lasers have been applied to various uncommon hair disorders. The purpose of this study was to demonstrate the clinical effects of fractional laser therapy on the course of primary follicular and perifollicular pathologies and subsequent hair regrowth. A retrospective review of 17 patients with uncommon hair disorders - including ophiasis, autosomal recessive woolly hair/hypotrichosis, various secondary cicatricial alopecias, pubic hypotrichosis, frontal fibrosing alopecia, and perifolliculitis abscedens et suffodiens - was conducted. All patients had been treated with non-ablative and/or ablative fractional laser therapies. The mean clinical improvement score in these 17 patients was 2.2, while the mean patient satisfaction score was 2.5. Of the 17 subjects, 12 (70.6%) demonstrated a clinical response to non-ablative and/or ablative fractional laser treatments, including individuals with ophiasis, autosomal recessive woolly hair/hypotrichosis, secondary cicatricial alopecia (scleroderma and pressure-induced alopecia), frontal fibrosing alopecia, and perifolliculitis abscedens et suffodiens. Conversely, patients with long-standing ophiasis, surgical scar-induced secondary cicatricial alopecia, and pubic hypotrichosis did not respond to fractional laser therapy. Our findings demonstrate that the use of non-ablative and/or ablative fractional lasers promoted hair growth in certain cases of uncommon hair disorders without any remarkable side effects.

A concrete approach to abstract algebra from the integers to the insolvability of the quintic

CERN Document Server

Bergen, Jeffrey

2010-01-01

A Concrete Approach to Abstract Algebra begins with a concrete and thorough examination of familiar objects like integers, rational numbers, real numbers, complex numbers, complex conjugation and polynomials, in this unique approach, the author builds upon these familar objects and then uses them to introduce and motivate advanced concepts in algebra in a manner that is easier to understand for most students. The text will be of particular interest to teachers and future teachers as it links abstract algebra to many topics wich arise in courses in algebra, geometry, trigonometry, preca

Increased gender variance in autism spectrum disorders and attention deficit hyperactivity disorder.

Science.gov (United States)

Strang, John F; Kenworthy, Lauren; Dominska, Aleksandra; Sokoloff, Jennifer; Kenealy, Laura E; Berl, Madison; Walsh, Karin; Menvielle, Edgardo; Slesaransky-Poe, Graciela; Kim, Kyung-Eun; Luong-Tran, Caroline; Meagher, Haley; Wallace, Gregory L

2014-11-01

Evidence suggests over-representation of autism spectrum disorders (ASDs) and behavioral difficulties among people referred for gender issues, but rates of the wish to be the other gender (gender variance) among different neurodevelopmental disorders are unknown. This chart review study explored rates of gender variance as reported by parents on the Child Behavior Checklist (CBCL) in children with different neurodevelopmental disorders: ASD (N = 147, 24 females and 123 males), attention deficit hyperactivity disorder (ADHD; N = 126, 38 females and 88 males), or a medical neurodevelopmental disorder (N = 116, 57 females and 59 males), were compared with two non-referred groups [control sample (N = 165, 61 females and 104 males) and non-referred participants in the CBCL standardization sample (N = 1,605, 754 females and 851 males)]. Significantly greater proportions of participants with ASD (5.4%) or ADHD (4.8%) had parent reported gender variance than in the combined medical group (1.7%) or non-referred comparison groups (0-0.7%). As compared to non-referred comparisons, participants with ASD were 7.59 times more likely to express gender variance; participants with ADHD were 6.64 times more likely to express gender variance. The medical neurodevelopmental disorder group did not differ from non-referred samples in likelihood to express gender variance. Gender variance was related to elevated emotional symptoms in ADHD, but not in ASD. After accounting for sex ratio differences between the neurodevelopmental disorder and non-referred comparison groups, gender variance occurred equally in females and males.

Investigating the role of attachment in social comparison theories of eating disorders within a non-clinical female population.

Science.gov (United States)

Bamford, Bryony; Halliwell, Emma

2009-01-01

The present study aimed to integrate attachment theory and sociocultural theory as predictors of disordered eating, thereby combining two previously distinct literatures in order to provide a more comprehensive model of eating disorder development. It was specifically proposed that women's attachment style may influence their tendency to socially compare themselves to idealized others. Participants (N = 213) were non-clinical female undergraduates. Sociocultural attitudes to appearance, social comparison, attachment and eating disorder symptomatology were assessed using self-report questionnaires. Consistent with the hypothesis, social comparison was found to mediate the relationship between attachment anxiety and disordered eating. In addition, attachment avoidance, was not significantly associated with either internalisation of cultural ideals or social comparison but was significantly related to eating psychopathology. The findings suggest that attachment anxiety and avoidance influence disordered eating via different pathways, with attachment anxiety specifically being implicated in sociocultural models of disordered eating.

The contribution of work and non-work stressors to common mental disorders in the 2007 Adult Psychiatric Morbidity Survey

Science.gov (United States)

Clark, C.; Pike, C.; McManus, S.; Harris, J.; Bebbington, P.; Brugha, T.; Jenkins, R.; Meltzer, H.; Weich, S.; Stansfeld, S.

2012-01-01

Background Evidence for an effect of work stressors on common mental disorders (CMD) has increased over the past decade. However, studies have not considered whether the effects of work stressors on CMD remain after taking co-occurring non-work stressors into account. Method Data were from the 2007 Adult Psychiatric Morbidity Survey, a national population survey of participants ⩾16 years living in private households in England. This paper analyses data from employed working age participants (N=3383: 1804 males; 1579 females). ICD-10 diagnoses for depressive episode, generalized anxiety disorder, obsessive compulsive disorder, agoraphobia, social phobia, panic or mixed anxiety and depression in the past week were derived using a structured diagnostic interview. Questionnaires assessed self-reported work stressors and non-work stressors. Results The effects of work stressors on CMD were not explained by co-existing non-work stressors. We found independent effects of work and non-work stressors on CMD. Job stress, whether conceptualized as job strain or effort–reward imbalance, together with lower levels of social support at work, recent stressful life events, domestic violence, caring responsibilities, lower levels of non-work social support, debt and poor housing quality were all independently associated with CMD. Social support at home and debt did not influence the effect of work stressors on CMD. Conclusions Non-work stressors do not appear to make people more susceptible to work stressors; both contribute to CMD. Tackling workplace stress is likely to benefit employee psychological health even if the employee's home life is stressful but interventions incorporating non-work stressors may also be effective. PMID:21896237

Trends in non-help-seeking for mental disorders in Germany between 1997-1999 and 2009-2012: a repeated cross-sectional study.

Science.gov (United States)

Brandstetter, Susanne; Dodoo-Schittko, Frank; Speerforck, Sven; Apfelbacher, Christian; Grabe, Hans-Jörgen; Jacobi, Frank; Hapke, Ulfert; Schomerus, Georg; Baumeister, Sebastian E

2017-08-01

This study sought to examine trends in non-help-seeking for mental disorders among persons with a prevalent mental disorder (12-month prevalence) in Germany between 1997-1999 and 2009-2012. We examined data from 1909 persons aged 18-65 years who participated in two independent, repeated cross-sectional surveys (German National Interview and Examination Study 1997-1999, German Health Interview and Examination Survey for Adults 2009-2012) conducted 12 years apart. Prevalent mental disorders (12-month prevalence) were determined using the Composite International Diagnostic Interview, which included information on lifetime help-seeking for mental health problems. Correlates of self-reported help-seeking were analyzed according to Andersen's Behavioral Model. Multivariable Poisson regression models were used to assess time trends in the directly standardized and model-adjusted prevalence of non-help-seeking across strata of socio-economic and clinical variables. The proportion of people with a prevalent mental disorder who have never sought help in their lifetime decreased significantly from 62% (95% CI 58.7-64.7) to 57% (95% CI 52.2-60.9) between 1997-1999 and 2009-2012 in adults aged 18-65 years in Germany. Downward trends in non-help-seeking occurred in all investigated strata and reached statistical significance in women, in people who were living alone, people with medium educational level, people living in middle-sized communities, people with non-statutory health insurance, smokers, and people with co-existing somatic conditions. Despite a downward trend over the course of 12 years, a large proportion of people suffering from mental disorders are still not seeking treatment in Germany. Further efforts to increase uptake of help-seeking for mental disorders in hard-to-reach groups are warranted to continue this trend.

Instantaneous and controllable integer ambiguity resolution: review and an alternative approach

Science.gov (United States)

Zhang, Jingyu; Wu, Meiping; Li, Tao; Zhang, Kaidong

2015-11-01

In the high-precision application of Global Navigation Satellite System (GNSS), integer ambiguity resolution is the key step to realize precise positioning and attitude determination. As the necessary part of quality control, integer aperture (IA) ambiguity resolution provides the theoretical and practical foundation for ambiguity validation. It is mainly realized by acceptance testing. Due to the constraint of correlation between ambiguities, it is impossible to realize the controlling of failure rate according to analytical formula. Hence, the fixed failure rate approach is implemented by Monte Carlo sampling. However, due to the characteristics of Monte Carlo sampling and look-up table, we have to face the problem of a large amount of time consumption if sufficient GNSS scenarios are included in the creation of look-up table. This restricts the fixed failure rate approach to be a post process approach if a look-up table is not available. Furthermore, if not enough GNSS scenarios are considered, the table may only be valid for a specific scenario or application. Besides this, the method of creating look-up table or look-up function still needs to be designed for each specific acceptance test. To overcome these problems in determination of critical values, this contribution will propose an instantaneous and CONtrollable (iCON) IA ambiguity resolution approach for the first time. The iCON approach has the following advantages: (a) critical value of acceptance test is independently determined based on the required failure rate and GNSS model without resorting to external information such as look-up table; (b) it can be realized instantaneously for most of IA estimators which have analytical probability formulas. The stronger GNSS model, the less time consumption; (c) it provides a new viewpoint to improve the research about IA estimation. To verify these conclusions, multi-frequency and multi-GNSS simulation experiments are implemented. Those results show that IA

Non-Specialist Psychosocial Interventions for Children and Adolescents with Intellectual Disability or Lower-Functioning Autism Spectrum Disorders: A Systematic Review

Science.gov (United States)

Yasamy, M. Taghi; Barbui, Corrado; Saxena, Shekhar

2013-01-01

Background The development of effective treatments for use by non-specialists is listed among the top research priorities for improving the lives of people with mental illness worldwide. The purpose of this review is to appraise which interventions for children with intellectual disabilities or lower-functioning autism spectrum disorders delivered by non-specialist care providers in community settings produce benefits when compared to either a no-treatment control group or treatment-as-usual comparator. Methods and Findings We systematically searched electronic databases through 24 June 2013 to locate prospective controlled studies of psychosocial interventions delivered by non-specialist providers to children with intellectual disabilities or lower-functioning autism spectrum disorders. We screened 234 full papers, of which 34 articles describing 29 studies involving 1,305 participants were included. A majority of the studies included children exclusively with a diagnosis of lower-functioning autism spectrum disorders (15 of 29, 52%). Fifteen of twenty-nine studies (52%) were randomized controlled trials and just under half of all effect sizes (29 of 59, 49%) were greater than 0.50, of which 18 (62%) were statistically significant. For behavior analytic interventions, the best outcomes were shown for development and daily skills; cognitive rehabilitation, training, and support interventions were found to be most effective for improving developmental outcomes, and parent training interventions to be most effective for improving developmental, behavioral, and family outcomes. We also conducted additional subgroup analyses using harvest plots. Limitations include the studies' potential for performance bias and that few were conducted in lower- and middle-income countries. Conclusions The findings of this review support the delivery of psychosocial interventions by non-specialist providers to children who have intellectual disabilities or lower-functioning autism

Non-specialist psychosocial interventions for children and adolescents with intellectual disability or lower-functioning autism spectrum disorders: a systematic review.

Directory of Open Access Journals (Sweden)

Brian Reichow

2013-12-01

Full Text Available BACKGROUND: The development of effective treatments for use by non-specialists is listed among the top research priorities for improving the lives of people with mental illness worldwide. The purpose of this review is to appraise which interventions for children with intellectual disabilities or lower-functioning autism spectrum disorders delivered by non-specialist care providers in community settings produce benefits when compared to either a no-treatment control group or treatment-as-usual comparator. METHODS AND FINDINGS: We systematically searched electronic databases through 24 June 2013 to locate prospective controlled studies of psychosocial interventions delivered by non-specialist providers to children with intellectual disabilities or lower-functioning autism spectrum disorders. We screened 234 full papers, of which 34 articles describing 29 studies involving 1,305 participants were included. A majority of the studies included children exclusively with a diagnosis of lower-functioning autism spectrum disorders (15 of 29, 52%. Fifteen of twenty-nine studies (52% were randomized controlled trials and just under half of all effect sizes (29 of 59, 49% were greater than 0.50, of which 18 (62% were statistically significant. For behavior analytic interventions, the best outcomes were shown for development and daily skills; cognitive rehabilitation, training, and support interventions were found to be most effective for improving developmental outcomes, and parent training interventions to be most effective for improving developmental, behavioral, and family outcomes. We also conducted additional subgroup analyses using harvest plots. Limitations include the studies' potential for performance bias and that few were conducted in lower- and middle-income countries. CONCLUSIONS: The findings of this review support the delivery of psychosocial interventions by non-specialist providers to children who have intellectual disabilities or lower

Comparison on Integer Wavelet Transforms in Spherical Wavelet Based Image Based Relighting

Institute of Scientific and Technical Information of China (English)

WANGZe; LEEYin; LEUNGChising; WONGTientsin; ZHUYisheng

2003-01-01

To provide a good quality rendering in the Image based relighting (IBL) system, tremendous reference images under various illumination conditions are needed. Therefore data compression is essential to enable interactive action. And the rendering speed is another crucial consideration for real applications. Based on Spherical wavelet transform (SWT), this paper presents a quick representation method with Integer wavelet transform (IWT) for the IBL system. It focuses on comparison on different IWTs with the Embedded zerotree wavelet (EZW) used in the IBL system. The whole compression procedure contains two major compression steps. Firstly, SWT is applied to consider the correlation among different reference images. Secondly, the SW transformed images are compressed with IWT based image compression approach. Two IWTs are used and good results are showed in the simulations.

An integer programming model for gate assignment problem at airline terminals

Science.gov (United States)

Chun, Chong Kok; Nordin, Syarifah Zyurina

2015-05-01

In this paper, we concentrate on a gate assignment problem (GAP) at the airlines terminal. Our problem is to assign an arrival plane to a suitable gate. There are two considerations needed to take. One of its is passenger walking distance from arrival gate to departure gate while another consideration is the transport baggage distance from one gate to another. Our objective is to minimize the total distance between the gates that related to assign the arrival plane to the suitable gates. An integer linear programming (ILP) model is proposed to solve this gate assignment problem. We also conduct a computational experiment using CPLEX 12.1 solver in AIMMS 3.10 software to analyze the performance of the model. Results of the computational experiments are presented. The efficiency of flights assignment is depends on the ratio of the weight for both total passenger traveling distances and total baggage transport distances.

An observational criterion to look for an inspiral in a non-Kerr spacetime

International Nuclear Information System (INIS)

Apostolatos, Theocharis A; Lukes-Gerakopoulos, Georgios; Deligiannis, John; Contopoulos, George

2009-01-01

In this short article we present a useful observational tool for gravitational wave detectors. More specifically, if we are looking for extreme-mass-ratio inspiraling objects in a non-Kerr spacetime, we could exploit the consequences of the KAM and the Poincare-Birkhoff theorem which predicts plateaus in the ratio of frequencies f ρ /f z , that are related to a generic geodesic orbit in such a spacetime, as a function of the initial conditions of the orbit itself. While both these frequencies are changing under radiation reaction, their ratio is expected to stay stationary if it passes through such a plateau. Therefore, if detectors are able to discern the fundamental frequencies due to ρ and z oscillations of the orbit, they could in principle detect the non-Kerr-ness of the spacetime involved, just by monitoring the ratio of these two frequencies.

Thickness dependence of the quantum Hall effect in films of the three-dimensional Dirac semimetal Cd3As2

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Manik Goyal

2018-02-01

Full Text Available Low-temperature magnetotransport studies are reported for (112Cd3As2 films grown on (111CdTe by molecular beam epitaxy as a function of the Cd3As2 film thickness. All films show Shubnikov-de Haas oscillations. An even-integer quantum Hall effect is observed for films thinner than 70 nm. For the thinnest films, the bulk is gapped and transport at low temperatures occurs only via the gapless, two-dimensional states. The lowest Landau level is reached at ∼10 T, and the longitudinal resistance nearly vanishes at the plateaus in the Hall resistance. The results are discussed in the context of the current theoretical understanding of topological surface states in three-dimensional Dirac semimetals.

A non linear ergodic theorem and application to a theorem of A. Pazy

International Nuclear Information System (INIS)

Djafari Rouhani, B.

1989-07-01

We prove that if (y n )n≥1 is a sequence in a real Hilbert space H such that for every non negative integer m the sequence (parallelΣ l =0 m y i +l parallel) i≥1 is non increasing, then: s n = 1/n Σ i=1 n y i converges strongly in H to the element of minimum norm in the closed convex hull of the sequence (y n ) n≥1 . We deduce a direct proof of a result containing a theorem of A. Pazy. (author). 27 refs

Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults.

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Chamberlain, Samuel R; Derbyshire, Katie L; Leppink, Eric W; Grant, Jon E

2016-06-01

Antisocial personality disorder (ASPD) is a relatively common problem, but the neuropsychological profile of affected individuals has seldom been studied outside of criminal justice recruitment settings. Non-treatment-seeking young adults (18-29 years) were recruited from the general community by media advertisements. Participants with ASPD (n = 17), free from substance use disorders, were compared with matched controls (n = 229) using objective computerized neuropsychological tasks tapping a range of cognitive domains. Compared with controls, individuals with ASPD showed significantly elevated pathological gambling symptoms, previous illegal acts, unemployment, greater nicotine consumption, and relative impairments in response inhibition (Stop-Signal Task) and decision-making (less risk adjustment, Cambridge Gamble Task). General response speed, set-shifting, working memory, and executive planning were intact. ASPD was also associated with higher impulsivity and venturesomeness on the Eysenck Questionnaire. These findings implicate impaired inhibitory control and decision-making in the pathophysiology of ASPD, even in milder manifestations of the disorder. Future work should explore the neural correlates of these impairments and use longitudinal designs to examine the temporal relationship between these deficits, antisocial behavior, and functional impairment. © 2016 American Academy of Psychiatry and the Law.

Integer linear models with a polynomial number of variables and constraints for some classical combinatorial optimization problems

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Nelson Maculan

2003-01-01

Full Text Available We present integer linear models with a polynomial number of variables and constraints for combinatorial optimization problems in graphs: optimum elementary cycles, optimum elementary paths and optimum tree problems.Apresentamos modelos lineares inteiros com um número polinomial de variáveis e restrições para problemas de otimização combinatória em grafos: ciclos elementares ótimos, caminhos elementares ótimos e problemas em árvores ótimas.

Thermodiffusion as a close-to-interface effect that matters in non-isothermal (dis)orderly protein aggregations

Energy Technology Data Exchange (ETDEWEB)

Gadomski, A., E-mail: agad@utp.edu.pl; Kruszewska, N., E-mail: nkruszewska@utp.edu.pl

2014-08-01

The goal of this discussion letter is to argue how and why an inherent nanoscale thermodiffusion (Soret-type) effect can be relevant in (dis)orderly protein aggregation. We propose a model in which the aggregation of proteins, in the presence of temperature gradient, is described in terms of Smoluchowski dynamics in the phase space of nuclei sizes. The Soret coefficient of the aggregation is proportional to the variations of the aggregation free energy over temperature. The free energy is related to the (interface) boundary condition of the system. When boundary condition is of equilibrium Gibbs–Thomson type, with a well-stated surface tension of the nucleus, to the system can be assigned a negative Soret effect. On the contrary, when a non-equilibrium perturbing (salting-out) term enters the boundary condition, a positive Soret effect may manifest. A zero-value Soret regime is expected to occur in between, yielding very soft (“fragile”) non-Kossel protein-type crystals. - Highlights: • Comprehension for non-isothermal formation of (dis)orderly protein aggregation. • Classification of temperature-sensitive morphologies in colloid-type aggregation. • Morphologies split into near-equilibrium and nonequilibrium structural outcomes. • Classification on mesoscopic nonequilibrium thermodynamics near local equilibrium.

Non-24-hour sleep-wake disorder revisited – A case study

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Corrado eGarbazza

2016-02-01

Full Text Available The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S, which rises linearly during the day, and a circadian process C, which determines the timing of sleep in an approximately 24h rhythm in accordance to the external light-dark (LD cycle. While both individual processes are fairly well characterized, the exact nature of their interaction remains unclear. The circadian rhythm is generated by the subthalamic nucleus (SCN, master clock of the anterior hypothalamus, through cell-autonomous feedback loops of DNA transcription and translation. While the phase length (tau of the cycle is relatively stable and genetically determined, the phase of the clock is reset by external stimuli (zeitgebers, the most important being the LD-cycle. Misalignments of the internal rhythm with the LD-cycle can lead to various somatic complaints and ultimately to the development of circadian rhythm sleep disorders (CRSD. Non-24-h sleep-wake disorders (N24HSWD is a CRSD affecting up to 50% of totally blind patients and characterized by the inability to maintain a stable entrainment of the typically long circadian rhythm (tau >24.5h to the LD- cycle. The disease is rare (<1:1 Mio in sighted individuals and the pathophysiology less well understood.Here we present the case of a 40 year old sighted male, who developed a misalignment of the internal clock with the external light-dark cycle following the treatment for Hodgkin’s lymphoma (ABVD regimen, 4 cycles and AVD regimen, 4 cycles. A thorough clinical assessment including actigraphy, melatonin profiles, polysomnography and wake-EEG lead to the diagnosis of a non-24-h sleep-wake disorders (N24HSWD with a free-running rhythm of tau=25.5h. A therapeutic intervention with bright-light therapy (BLT, 30 min 10.000lux in the morning and melatonin administration (0.5-0.75 mg in the evening failed to entrain the free-running rhythm, although a longer treatment duration and more

Non-abelian bosonization without Wess-Zumino terms. Pt. 1

International Nuclear Information System (INIS)

Rajeev, S.G.

1989-01-01

It is conjectured that the non-linear sigma-model without Wess-Zumino terms is equivalent as a quantum theory to the non-abelian massless Thirring model. However, the standard (Sugawara) current algebra of the non-linear model is not isomorphic to that of the fermionic theory. A new current algebra formalism is proposed, which depends on a parameter k. As k → ∞ it reduces to the Sugawara formalism. The new current algebra is isomorphic to the fermionic one, being the direct sum of two Kac-Moody algebras with opposite central terms. In the quantum theory, k (which is the level number) has to be an integer. The new formalism is shown to preserve Poincare and conformal invariance classically. The new current algebra is derived canonically and a new action principle for the non-linear model is proposed. (orig.)