Acquired factor XII deficiency in a woman with recurrent pregnancy loss: working on a differential diagnosis in a single case

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Di Micco Pierpaolo

2005-12-01

Full Text Available Abstract Background Antiphospholipid syndrome (APS has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS. Case history We report the case history of 34-year-old caucasian women with recurrent fetal loss and persistent prolonged activated partial thromboplastin time. Haemostatic tests revealed persistent light decrease of clotting factor XII with normal values of IgG and IgM anticardiolipin antibodies and transient positivity for lupus anticoagulant (LA. Few reports in the Literature described antibodies to factor XII in patient with antiphospholipid syndrome (APS and transient LA. So, once other causes of RPL were excluded, the patient was diagnosed an unusual form of APS associated to antibodies to factor XII, reduced factor XII plasma levels, transient LA and prolonged activated partial thromboplastin time. Discussion We suggest to consider also antibodies directed to clotting factors (e.g. factor XII in our case as second step of thrombophilia screening in RPL, in particular if a persistent prolonged aPTT is present without an apparent cause.

Use of Al XII and Mg XI lines as solar plasma diagnostics

International Nuclear Information System (INIS)

Bromage, B.J.I.; Phillips, K.J.H.; Keenan, F.P.; McCann, S.M.

1989-09-01

We present three sets of observations of n=1 to n=2 lines due to helium-like aluminium (Al XII), made during two solar flares (25 August, 1980 and 19 October, 1986), using the X-ray Polychromator on satellite. The observed temperature-sensitive line ratio G is shown to be consistent with previously observed close-coupling calculations, although the ratio R, which is both temperature and density-sensitive for lower-Z elements, is not sufficiently well determined from these data to say more than that the observed values of R are not inconsistent with the theoretical calculations. This region of the spectrum also includes the helium-like magnesium (Mg XI) 1 1 S-3 1 P line, and it is shown that the ratio of this line to the Al XII resonance (1 1 S-2 1 P) line is a more sensitive indicator of electron temperature than are the Al XII G and R ratios. We demonstrate that the three ratios may be used together in order to derive values of emission measure, electron temperature and electron density during these flares. (author)

Special issue: Proceedings of the XII. Czech Ichthyological Conference

Czech Academy of Sciences Publication Activity Database

Kubečka, Jan

2011-01-01

Roč. 60, č. 2 (2011), s. 91-92 ISSN 0139-7893. [Czech Ichthyological Conference /XII./. Vodňany, 19.05.2010-20.05.2010] Institutional research plan: CEZ:AV0Z60170517 Keywords : zoology * ichthyology Subject RIV: EG - Zoology Impact factor: 0.554, year: 2011

2. XII möödus 20 aastat Adamson-Ericu muuseumi avamisest Eesti Kunstimuuseumi filiaalina ning 35 aastat Adamson-Ericu (1902-1968) surmast

Index Scriptorium Estoniae

2003-01-01

Muuseumi ajaloost, põhikogust, Adamson-Ericu teoste põhiekspositsioonist, kunstinäitustest. 3. XII tutvustab Kersti Koll Adamson-Ericu ja läti kunstniku Ludolfs Libertsi näitust. 5. XII ekspositsioonis ringkäik "Meistri töövõtetest ning erinevatest materjalidest restauraatori pilgu läbi" Alar Nurkse juhtimisel, ekskursioon Ülle Kruusi juhtimisel. 10. XII algab projekti "Avatud muuseum" raames haridusprogramm "Noor kunstidetektiiv"

Analyses of the Sn IX-Sn XII spectra in the EUV region

International Nuclear Information System (INIS)

Churilov, S S; Ryabtsev, A N

2006-01-01

The Sn IX-Sn XII spectra excited in a vacuum spark have been analysed in the 130-160 A wavelength region. The analysis was based on the energy parameter extrapolation in the isonuclear Sn VI-VIII and Sn XIII-XIV sequence. 266 spectral lines belonging to the 4d m -(4d m-1 4f+4p 5 4d m+1 ) (m=6-3) transition arrays were classified in the Sn IX-Sn XII spectra for the first time. All 18 level energies of the 4d 3 configuration and 39 level energies of the strongly interacting 4d 2 4f and 4p 5 4d 4 configurations were established in the Sn XII spectrum. The energy differences between the majority of the 4d m levels and about 40 levels of the 4d m-1 4f+4p 5 4d m+1 configurations were determined in each of the Sn IX, Sn X and Sn XI spectra (m=6-4). As a result, all intense lines were classified in the 130-140 A region relevant to the extreme ultraviolet (EUV) lithography. It was shown that the most of the intense lines in the 2% bandwidth at 135 A belong to the transitions in the Sn XI-Sn XIII spectra

XII seminar on problems of reactor physics

International Nuclear Information System (INIS)

Kryuchkov, Eh.F.; Naumov, V.I.

2003-01-01

Results of the XII seminar Physical problems of effective and safety use of nuclear materials taking place on the basis of MEPI (September, 2002) are discussed. Reports on the directions: physical problems of advanced nuclear-energetic technologies; account, control and nuclear material management; effective and safety use of nuclear materials at NPP; programming and software for the analysis of physical processes are performed. Of particular interest is reports on actual problems of nuclear energetics and fuel cycle, on ill-intentioned use of fissile materials, efficiency of long-lived isotopes transmutation and spent fuel management [ru

Ludus de Antichristo e o drama da escatologia imperial no século XII

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Vinicius Cesar Dreger de Araújo

2013-09-01

Full Text Available Buscamos neste texto analisar as imbricações entre o texto teatral germânico do século XII, o Ludus de Antichristo, e o seu contexto político-cultural, particularmente em relação às personagens do Anticristo e do Último Imperador Romano, seus protagonistas, com a Escatologia Imperial encontrada no período. Nosso artigo contém um detalhado resumo da peça, estudos relacionados às tradições e documentos que levaram à sua concepção e seu enquadramento nos debates políticos e religiosos do século XII.

Multiplier Effect Industri Pariwisata Candi Muara Takus Terhadap Perekonomian Masyarakat Di Kecamatan XII Koto Kampar Kabupaten Kampar

OpenAIRE

Ikhsan, Muhammad; ', Mardiana; Setiawan, Deny

2017-01-01

The research was carried on in Kampar regency precisely in the District XII Koto Kampar. This study was conducted in Kampar regency located in District XII Koto Kampar. This study aims to (1) Identify the characteristics of visitors, businessmen and labor (2) To identify the perception of the condition of Tourism Muara Takus by visitors, businesses and workers in the tourist area (3) Measuring multiplier effet that caused by Muara Takus tourist activities on the economy of the community. The ...

PENGARUH PRESTASI PRAKTIK KERJA INDUSTRI DAN HASIL BELAJAR KEWIRAUSAHAAN TERHADAP MINAT BERWIRAUSAHAAN SISWA KELAS XII AKUNTANSI SMK NEGERI 25 JAKARTA

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DESTA AMBARSARI

2016-03-01

Full Text Available This research purpose is to find out the influence of industrial practice and entrepreneurship learning achievement to entrepreneurship interest, XII Accounting Class in SMK Negeri 25 Jakarta. This type of research is survey, with quantitative approach. Data recording, interview and questionnaire are research technique. Sampling technique used proportional random sampling. Total population in this study were 77 students with a sample of 64 students of XII accounting class in SMK Negeri 25 Jakarta. The results showed that: there is a significant positive influence of industrial practice and entrepreneurship learning achievement to entrepreneurship interest, XII Accounting Class in SMK Negeri 25 Jakarta. Thus if industrial practice and entrepreneurship learning achievement increases, the entrepreneurship interest will also increase.

Demonstration of resonant photopumping of Mo VII by Mo XII for a VUV laser near 600 Angstrom

International Nuclear Information System (INIS)

Ilcisin, K.J.; Aumayr, F.; Schwob, J.L.; Suckewer, S.

1993-09-01

We present data of experiments on the resonant photopumping of Mo VII by Mo XII as a method of generating a coherent VUV source near 600 angstrom. The experiment is based on a scheme proposed by Feldman and Reader in which the 4p 6 -- 4p 5 6s transition in Mo VII in resonantly photopumped by the 5s 2 S 1/2 -- 4p 2 P 1/2 transition in Mo XII. Results of the laser produced plasma experiments show the successful enhancement of the population of the Mo VII 4p 5 6s upper lasing level when pumped by an adjacent Mo VII plasma. No enhancement was seen in a control experiment where the Mo VII plasma was pumped by a Zr X plasma. Improvements of the intensity of the Mo XII pump source, achieved using an additional pump laser, lead to the generation of a population inversion for the VUV transition

Retinal venous thrombosis in a young patient with coagulation factor XII deficiency.

Science.gov (United States)

Borrego-Sanz, L; Santos-Bueso, E; Sáenz-Francés, F; Martínez-de-la-Casa, J M; García-Feijoo, J; Gegúndez-Fernández, J A; García-Sánchez, J

2014-08-01

A 35-year-old woman, with no relevant medical history, was referred for sudden vision loss in the left eye. Ophthalmological examination showed best corrected visual acuity of 1.0 in the right eye and 0.3 in left eye, with normal anterior pole and intraocular pressure. Fundus examination of the left eye revealed a venous thrombosis in the superior temporal branch, with dilated and tortuous retinal veins. The patient was referred to the hematology unit for thrombophilia study, and was diagnosed with a coagulation XII or Hageman factor deficiency. The development of retinal vessel occlusions, in patients under 50 years of age, is frequently associated with thrombophilia or hypercoagulability disorders. Factor XII deficiency is a rare condition, and its presence could contribute to a higher risk of thromboembolic events. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

Ramsay Hunt syndrome with unilateral polyneuropathy involving cranial nerves V, VII, VIII, and XII in a diabetic patient.

Science.gov (United States)

Sun, Wei-Lian; Yan, Jian-Liang; Chen, Li-Li

2011-01-01

Ramsay Hunt syndrome is a rare complication of the varicella zoster virus, defined as a peripheral facial palsy that typically results from involvement of the facial and auditory nerves. Ramsay Hunt syndrome can be associated with cranial nerves V, VI, IX, and X but rarely with XII. We describe an atypical case of Ramsay Hunt syndrome with multiple cranial nerve involvement of nerves V, VII, VIII, and XII. Antiviral drugs, antibiotics, insulin, and traditional Chinese drugs were administered immediately after admission. After 3 months of combination therapy, the patient had recovered satisfactorily. Herpes zoster can cause severe infections in diabetic patients and should be treated as soon after detection as possible. Ramsay Hunt syndrome should be recognized as a polycranial neuritis characterized by damage to sensory and motor nerves. In addition to facial and vestibular nerve paralysis, Ramsay Hunt syndrome may also involve cranial nerves V and XII.

Progress in direct-drive laser fusion using GEKKO XII/PW facility

International Nuclear Information System (INIS)

Yamanaka, T.

2002-01-01

Extensive studies have been carried out for the fast-ignitor laser fusion which can provide one of the most feasible short tracks in the fusion energy development. We have upgraded the heating laser up to 1 PW(500 J/500 fs) and have started comprehensive studies on the transport of high current relativistic electron beam in the dense plasma. Substantial heating of the core plasma up to 1 keV is expected with implosion plasma produced by the Gekko XII laser. We have experimentally obtained for the first time all parameters to decide the growth rate of Rayleigh-Taylor instability using the HIPER irradiation system which can generate ablation pressure up to 60 Mbar and newly developed advanced x-ray diagnostic tools. We have proposed the FIREX (Fast Ignitor Realization Experiment) program for demonstrating the proof-of-principle of fast ignitor scheme. By the irradiation of ∼10 kJ/2-10 ps laser onto a DT core plasma formed by the GEKKO-XII, we are aiming at temperature of >8 keV and the fusion gain near unity. (author)

Trombosis cerebral en presencia de un inhibidor especifico contra el factor XII de la coagulación

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Octavio Martínez Betancur

1998-04-01

Full Text Available We report the presence of an specific inhbitor directed against Hageman factor (factor XII in a male patient who suffered occlusive stroke and showed tomografic evidence of multiple previous brain infarcts. The presence of a lupus anticoagulant was excluded by means of the platelet neutralisation test. The reduction of the fibrinolytic activity in response to thrombosis as a result of factor XII inhibition was demonstrated by the abnormal prolongation of the euglobin lysis time as well as the absence of fibrin degradation products (negative D-dimer assay and ethanol gelation test.

Platonismo e Aristotelismo no século XII (I

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Ruy Afonso da Costa Nunes

1968-09-01

Full Text Available Consagro esta monografia ao estudo de "Platonismo e Aristote-lismo no século XII". Sua concisão talvez não corresponda ao vulto das leituras e consultas a que o tema me compeliu. Confesso, entre-tanto, que ela corresponde aos intuitos com que a concebi, após ter recebido a incumbência de redigí-Ia durante o curso de doutoramen-to, para a cadeira de Língua e Literatura Latina .

XII ASSEMBLEIA GERAL ORDINÁRIA DO SÍNODO DOS BISPOS SOBRE A PALAVRA DE DEUS

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Johan Konings

2009-01-01

Full Text Available Em outubro de 2008 transcorreu em Roma a XII Assembleia Geral Ordin ária do Sínodo dos Bispos, o qual é uma instituição permanente criada pelo Concílio Vaticano II para manter o diálogo dos pastores-bispos das Igrejas particulares. Nesta Assembleia, dedicada à Palavra de Deus na vida e na missão da Igreja, foi retomada praticamente a Constituição Dogmática Dei Verbum do Vaticano II. Depois de apresentar o tema da Palavra de Deus, traçamos um breve histórico focalizando os inícios da Tradição cristã e os tempos modernos desde Leão XIII até hoje. Em seguida descrevemos a XII Assembleia Geral, especialmente a Relatio post Disceptationem e as Propositiones. Concluímos com uma reflexão teológicopastoral sobre a Revelação e a leitura bíblica, e sugestões para a prática. ABSTRACT: In October of 2008 the XII Ordinary General Assembly of the Sinod of Bishops took place in Rome. The Sinod of Bishops is a permanent institution created by the II Vatican Council in order to maintain the dialogue of pastorsbishops of the particular Churches. This Assembly, dedicated to the Word of God in the life and in the mission of the Church, basically treated again the Dogmatic Constitution Dei Verbum of the II Vatican Council. After presenting the theme of the Word of God, we outline a brief history focusing on the beginnings of the Christian Tradition and the modern epoch since Leo XIII until today. Next we describe the XII General Assembly, especially the Relatio post Disceptationem and the Propostiones. We conclude with a theological-pastoral reflection on Revelation and the reading of the bible, and some practical suggestions.

Forces necessary for the disruption of the cisternal segments of cranial nerves II through XII.

Science.gov (United States)

Tubbs, R Shane; Wellons, John C; Blount, Jeffrey P; Salter, E George; Oakes, W Jerry

2007-04-01

Manipulation of the cisternal segment of cranial nerves is often performed by the neurosurgeon. To date, attempts at quantifying the forces necessary to disrupt these nerves in situ, to our knowledge, has not been performed. The present study seeks to further elucidate the forces necessary to disrupt the cranial nerves while within the subarachnoid space. The cisternal segments of cranial nerves II through XII were exposed in six unfixed cadavers, all less than 6 hr postmortem. Forces to failure were then measured. Mean forces necessary to disrupt nerves for left sides in increasing order were found for cranial nerves IX, VII, IV, X, XII, III, VIII, XI, VI, V, and II, respectively. Mean forces for right-sided cranial nerves in increasing order were found for cranial nerves IX, VII, IV, X, XII, VIII, V, VI, XI, III, and II, respectively. Overall, cranial nerves requiring the least amount of force prior to failure included cranial nerves IV, VII, and IX. Those requiring the highest amount of force included cranial nerves II, V, VI, and XI. There was an approximately ten-fold difference between the least and greatest forces required to failure. Cranial nerve III was found to require significantly (P cranial nerves II through XII. We found that cranial nerve IX consistently took the least amount of force until its failure and cranial nerve II took the greatest. Other cranial nerves that took relatively small amount of force prior to failure included cranial nerves IV and VII. Although in vivo damage can occur prior to failure of a cranial nerve, our data may serve to provide a rough estimation for the maximal amount of tension that can be applied to a cranial nerve that is manipulated while within its cistern.

La host (1998) Any XII. Núm. 7

OpenAIRE

Alè Revest, Josep Lluis; Agustí i Vicent, Joan; Belenguer, Emília; Sánchez-Pantoja Domínguez, Albert; Francisco, José Vicente; Trilles Font, Joan Josep; Gómez, Vicent; García Moliner, Federico; García, Agustín; Vicente, Ricardo; Alcón, Jaume; Gimeno, Vicent; Pallarés, Joan; Fernandez Jurado, Ramón; Lauterio, Amàlia

1998-01-01

SUMARI: Salutació.Crònica reial.La host.La torre dels Alçaments (i II).Casa i Cort dels reis d'Aragó (II).El bou en la cultura mediterrània.Joan Fuster,"in memoriam".Les illes columbretes.Bernat de Ventadorn, trobador d'ofici.Sant Antoni: Animals, dimonis i foc.III Capitol de l'arros i la taronja.Decàleg de promeses solemnes.Decàleg de promeses solemnes.Guijuelo:23-II-97 I capitol del jamón (XII jornadas de la matanza).Hernani: 23-III-97 II capítol de la sidra.Santander: 20-IV-97 XIII Capítol...

HUBUNGAN PENGALAMAN PRAKTIK KERJA INDUSTRI DAN PRESTASI BELAJAR KEJURUAN DENGAN MINAT BERWIRAUSAHA SISWA KELAS XII TKR SMK COKROAMINOTO 2 BANJARNEGARA TAHUN PELAJARAN 2015/2016

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Bayu Sandhi Pamungkas

2016-06-01

Results of this research is: (1 Industry experience working practices positively and significantly related with interest in entreprenuership class XII TKR student of SMK Cokroaminoto 2 Banjarnegara academic year 2015/2016; (2 Vocational learning achievement positively and significantly related with interest in entrepreneurship class XII TKR student of SMK Cokroaminoto 2 Banjarnegara academic year 2015/2016; (3 Industry experience working practices and vocational learning achievement  together positively and significantly related with interest in entrepreunership class XII TKR student of SMK Cokroaminoto 2 Banjarnegara academic year 2015/2016

Development of Instructional Materials for Electrochemical Module Class XII Science High School Students with Guided Inquiry Learning Approach

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Lilik Fatmawati

2014-06-01

Full Text Available Pengembangan Bahan Ajar Modul Elektrokimia untuk Siswa SMA Kelas XII IPA dengan Pendekatan Pembelajaran Inkuiri Terbimbing Abstract: The aim of this study was to determine the feasibility and effectiveness of the electrochemical module for high school students of class XII results of development. Electrochemical module of the development consists of two learning activities, ie to the material Volta cells and electrolysis cells for the material. Results of the assessment by two chemistry lecturer, State University of Malang and two chemistry teachers XII as an expert content / learning material for eligibility contents was 92.9%, for eligibility and completeness of presentation is 91.1%, and for the eligibility of language is 92.3% , which is classified as very feasible criteria. Overall the average value was 92.1 feasibility. Effectiveness module is indicated by the results of the development of perception and student learning outcomes. Students' perceptions obtained from student assessment results to module development. In the limited field trials obtained average value is 81.8 for all aspects of the maximum value of 100. Obtaining the average value of student learning outcomes for the cognitive aspect is 83.3, for the affective aspect is 82.3, and for the psychomotor aspect is 83.8 out of 100. The maximum value of the overall results of the study showed that the electrochemical module for high school students Class XII Science development results are very decent and very effectively used in the learning process. Key Words: guided inquiry, electrochemical module, model 4-D Abstrak: Tujuan penelitian ini adalah mengetahui kelayakan, dan keefektifan modul elektrokimia untuk siswa SMA kelas XII hasil pengembangan. Modul Elektrokimia hasil pengembangan terdiri dari dua kegiatan belajar, yaitu untuk materi sel Volta dan untuk materi sel elektrolisis. Hasil penilaian oleh dua dosen kimia Universitas Negeri Malang dan dua guru kimia kelas XII sebagai

Evaluation of 177Lu[Lu]-CHX-A″-DTPA-6A10 Fab as a radioimmunotherapy agent targeting carbonic anhydrase XII.

Science.gov (United States)

Fiedler, L; Kellner, M; Gosewisch, A; Oos, R; Böning, G; Lindner, S; Albert, N; Bartenstein, P; Reulen, H-J; Zeidler, R; Gildehaus, F J

2018-05-01

Due to their infiltrative growth behavior, gliomas have, even after surgical resection, a high recurrence tendency. The approach of intracavitary radioimmunotherapy (RIT) is aimed at inhibiting tumor re-growth by directly administering drugs into the resection cavity (RC). Direct application of the radioconjugate into the RC has the advantage of bypassing the blood-brain barrier, which allows the administration of higher radiation doses than systemic application. Carbonic anhydrase XII (CA XII) is highly expressed on glioma cells while being absent from normal brain and thus an attractive target molecule for RIT. We evaluated a CA XII-specific 6A10 Fab (fragment antigen binding) labelled with 177 Lu as an agent for RIT. 6A10 Fab fragment was modified and radiolabelled with 177 Lu and characterized by MALDI-TOF, flow cytometry and radio-TLC. In vitro stability was determined under physiological conditions. Biodistribution studies, autoradiography tumor examinations and planar scintigraphy imaging were performed on SCID-mice bearing human glioma xenografts. The in vitro CA XII binding capacity of the modified Fab was confirmed. Radiochemical purity was determined to be >90% after 72 h of incubation under physiological conditions. Autoradiography experiments proved the specific binding of the Fab to CA XII on tumor cells. Biodistribution studies revealed a tumor uptake of 3.0%ID/g after 6 h and no detectable brain uptake. The tumor-to-contralateral ratio of 10/1 was confirmed by quantitative planar scintigraphy. The radiochemical stability in combination with a successful in vivo tumor uptake shows the potential suitability for future RIT applications with the 6A10 Fab. Copyright © 2018 Elsevier Inc. All rights reserved.

NPP safety and personnel training. XII International conference. Abstracts. Volume 2

International Nuclear Information System (INIS)

2011-01-01

The XII International conference NPP Safety and Personnel Training took place in Obninsk, October 4-7 2011. The problems of personnel training for nuclear industry are discussed. The innovation nuclear systems and fuel cycle are considered. The much attention has been given to NPP radiation safety and radioecology issues. The recent high-speed computation and simulation methods used in reactor technology are presented [ru

PENERAPAN SIMASET PADA MATERI LAPORAN PENERIMAAN DAN PENDISTRIBUSIAN SARANA DAN PRASARANA UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA KELAS XII ADMINISTRASI PERKANTORAN SMKN 1 MALANG

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Novi Damayanti

2017-11-01

Full Text Available XII APK 1 class at SMKN 1 Malang have a problem on their learning motivation that showed by their attitude at the time of learning. The student’s motivation is relatively low. It is because the material, which is the report of facilities and infrastructure reception and distribution, requires a high concentration, therefore they need SIMAset as learning media that can help them to reach the goal of learning. The purpose of this research is to increase student’s motivation. This research is Classroom Action Research (CAR that was conducted in two cycles in which each cycle consist of planning, implementation, observation, and reflection. Data collection techniques in this study was done by using observation, interview, test, documentation, and questionnaire. This research using qualitative interactive techniques data analysis. The result of this study showed that SIMAset can increase student motivation. Abstrak: Kelas XII APK 1 SMKN 1 Malang memiliki permasalahan pada motivasi belajar yang ditunjukkan oleh sikap siswa pada saat proses pembelajaran berlangsung. Motivasi belajar siswa kelas XII APK 1 SMKN 1 Malang relatif rendah. Hal tersebut disebabkan karena materi yang dipelajari yaitu laporan penerimaan dan pendistribusian sarana dan prasarana membutuhkan konsentrasi yang tinggi, sehingga dibutuhkan media pembelajaran SIMAset yang dapat membantu siswa untuk mencapai tujuan pembelajaran dengan baik. Penelitian ini bertujuan untuk meningkatkan motivasi belajar siswa. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK yang dilaksanakan dalam dua siklus, masing-masing siklus terdiri atas tahap perencanaan, pelaksanaan, pengamatan, dan refleksi. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara, tes, dokumentasi, dan angket. Analisis data menggunakan teknik analisis data kualitatif interaktif. Hasil penelitian menunjukkan bahwa SIMAset dapat meningkatkan motivasi belajar siswa.

Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD

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Sergey Mikhailovich Slepchenko

2015-01-01

Full Text Available We present a paleoparasitological analysis of the medieval Zeleniy Yar burial ground of the XII-XII centuries AD located in the northern part of Western Siberia. Parasite eggs, identified as eggs of Opisthorchis felineus, were found in the samples from the pelvic area of a one year old infant buried at the site. Presence of these eggs in the soil samples from the infant’s abdomen suggests that he/she was infected with opisthorchiasis and imply consumption of undercooked fish. Ethnographic records collected among the population of the northern part of Western Siberia reveal numerous cases of feeding raw fish to their children. Zeleniy Yar case of opisthorchiasis suggests that this dietary custom has persisted from at least medieval times.

Factor XII (Hageman factor) is a missing link between stress and hypercoagulability and plays an important role in the pathophysiology of ischemic stroke.

Science.gov (United States)

Eggers, Arnold E

2006-01-01

A new hypothesis is presented on the function of factor XII, which is postulated to be a "missing link" between acute stress and transient hypercoagulability. The implications of this idea are developed to show how chronic stress, which involves activation of hypertension and migraine as well as hypercoagulability, can cause of cerebrovascular disease. "Acute stress" is defined as "the normal short-term physiological response to the perception of major threats or demands". "Chronic stress" is "the abnormal ongoing physiological response to the continuing perception of unresolvable major threats or demands". The factor XII hypothesis is as follows: Acute stress includes release of epinephrine by the adrenal medulla. Epinephrine activates platelets by binding to alpha-2A adrenergic receptors. Activated platelets convert pre-bound factor XII to its active form, which then initiates the intrinsic coagulation cascade. This can be called the "activated platelet initiation pathway" for coagulation. Neither tissue factor nor pre-formed thrombin is required. Thrombosis proceeds to completion, but only a minute amount of thrombin is formed, and the process normally stops at this point. In people who lapse into a state of chronic stress, essential hypertension, which is also a manifestation of stress, synergizes with hypercoagulability: there is both a baseline rise in blood pressure and systemic platelet activation as well as superimposed labile rises of both. Upregulation of these two stress parameters is atherogenic: epinephrine-activated platelets stimulating thrombin formation interact with endothelial cells activated by angiotensin II to cause, first, smooth muscle cell proliferation, which is a histological hallmark of atherosclerosis, and, lastly, a symptomatic thrombotic occlusion-the stroke. The migraine symptoms which often accompany this process are a marker of chronic stress and ongoing pathophysiologic damage. Therapeutic predictions are made regarding novel

PENGARUH MOTIVASI BELAJAR EKONOMI, GENDER DAN LINGKUNGAN PONDOK PESANTREN (SUNAN PANDANARAN TERHADAP PERILAKU BELAJAR EKONOMI SISWA DI KELAS PADA SISWA KELAS XII IPS PUTRA DAN XII IPS PUTRI MA SUNAN PANDANARAN SLEMAN, YOGYAKARTA

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Siti Masruroh

2015-11-01

Full Text Available Penelitian ini bertujuan untuk menguji pengaruh motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran terhadap perilaku belajar ekonomi siswa di kelas baik secara simultan maupun parsial. Populasi dan sampel pada penelitian ini adalah siswa kelas XII IPS Putra dan siswi kelas XII IPS Putri. Metode pengumpulan data dalam penelitian ini menggunakan metode angket/kuesioner. Variabel dependen pada penelitian ini yaitu perilaku belajar ekonomi siswa di kelas. Variabel independennya yaitu motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran. Hasil uji hipotesis simultan menunjukkan bahwa ada pengaruh motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran terhadap perilaku belajar ekonomi siswa di kelas. Hasil uji hipotesis secara parsial menunjukkan bahwa ada pengaruh motivasi belajar ekonomi terhadap perilaku belajar ekonomi siswa di kelas, ada pengaruh gender terhadap perilaku belajar ekonomi siswa di kelas dan ada pengaurh lingkungan pondok pesantren (Sunan Pandanaran terhadap perilaku belajar ekonomi siswa di kelas. Simpulan dari penelitian ini yaitu motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran berpengaruh terhadap perilaku belajar ekonomi siswa di kelas baik secara simultan maupun secara parsial. Untuk penelitian selanjutnya diharapkan dapat menggunakan variabel lain yang tidak digunakan dalam penelitian ini seperti minat terhadap mata pelajaran ekonomi dan dukungan orang tua yang secara parsial maupun simultan dapat berpengaruh terhadap perilaku belajar ekonomi siswa di kelas. This study aimed to examine the effect of learning motivation economic, gender and environmental Boarding Sunan Pandanaran the behavior of students in the classroom studying economics either simultaneously or partially. Population and sample in this research were students of class XII IPS grader son and daughter XII IPS. Data collection method in

Collagen XII and XIV, New Partners of Cartilage Oligomeric Matrix Protein in the Skin Extracellular Matrix Suprastructure*

Science.gov (United States)

Agarwal, Pallavi; Zwolanek, Daniela; Keene, Douglas R.; Schulz, Jan-Niklas; Blumbach, Katrin; Heinegård, Dick; Zaucke, Frank; Paulsson, Mats; Krieg, Thomas; Koch, Manuel; Eckes, Beate

2012-01-01

The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone. PMID:22573329

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.

Science.gov (United States)

Agarwal, Pallavi; Zwolanek, Daniela; Keene, Douglas R; Schulz, Jan-Niklas; Blumbach, Katrin; Heinegård, Dick; Zaucke, Frank; Paulsson, Mats; Krieg, Thomas; Koch, Manuel; Eckes, Beate

2012-06-29

The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone.

XII All-Russian conference on gas chromatography. Program. Summary of reports

International Nuclear Information System (INIS)

2002-01-01

Program and summary of reports of the XII All-Russian conference on gas chromatography are performed. The conference took place in Samara, 10-14 June, 2002. Reports on physicochemical regularities of gas chromatography, application of chromatographic methods in atomic energetics are included in the program of the conference. Part of the reports are deleted to the analytical application of the gas chromatography. Adsorbents for the gas chromatography, complex methods, mathematic methods in chromatography, ecological aspects of the gas chromatography [ru

PENGEMBANGAN MEDIA AJAR LINE FOLLOWER ANALOG PADA MATA PELAJARAN PEREKAYASAAN SISTEM ROBOTIK KELAS XII TEKNIK ELEKTRONIKA INDUSTRI

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Suwasono Suwasono

2017-01-01

Full Text Available This research aims at developing line follower analog media for robotic system engineering in SMKN 2 Singosari. The development was refered to modified model suggested by Sugiyono. The results of this development are in the form of modul, jobsheet, and trainer for robotic system engineering. The product was validated by content expertise I from Electrical Engineering Lecturer and obtained 92,06% of validity result. While the valifity result given the content expertise II from Robotic System Engineering teacher obtained 92,77%. In terms of media validity, the product obtained 94,81% from Electrical Engineering Lecturer and 94,02% from Robotic System Engineering Teacher. The product was also tested in XII Graders of Industry Electronics Engineering in SMKN 2 Singosari and obtained 88,20%. Thus, the media developed in the form of modul, jobsheet, and trainer of Robotic System Engineering within this study is considered as appropriate for XII Graders of Industry Electronics Engineering in SMKN 2 Singosari. Penelitian ini bertujuan untuk mengembangkan media ajar line follower analog pada mata pelajaran perekayasaan sistem robotik di SMKN 2 Singosari. Penelitian pengembangan mengacu pada model pengembangan Sugiyono yang dimodifikasi. Hasil pengembangan media ajar line follower analog berupa modul, jobsheet dan trainer untuk mata pelajaran Perekayasaan Sistem Robotik. Produk divalidasi ahli materi I dosen dari Jurusan Teknik Elektro memperoleh persentase sebesar 92,06%, ahli materi II dari guru mata pelajaran Perekayasaan Sistem Robotik memperoleh persentase sebesar 92,77%. Validasi media I dosen dari Jurusan Teknik Elektro memperoleh hasil persentase sebesar 94,81%, ahli media II dari guru mata pelajaran Perekayasaan Sistem Robotik memperoleh persentase sebesar 94,02%. Produk juga diujicobakan pada siswa kelas XII Teknik Elektronika Industri SMKN 2 Singosari diperoleh persentase sebesar 88,20% dan termasuk dalam kategori sangat layak. Sehingga produk

FOREWORD: The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009) The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009)

Science.gov (United States)

Orlando, Thomas M.; Diebold, Ulrike

2010-03-01

The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) took place from 19-23 April 2009 in Pine Mountain, Georgia, USA. This was the 12th conference in a strong and vibrant series, which dates back to the early 1980s. DIET XII continued the tradition of exceptional interdisciplinary science and focused on the study of desorption and dynamics induced by electronic excitations of surfaces and interfaces. The format involved invited lectures, contributed talks and a poster session on the most recent developments and advances in this area of surface physics. The Workshop International Steering Committee and attendees wish to dedicate DIET XII to the memory of the late Professor Theodore (Ted) Madey. Ted was one of the main pioneers of this field and was one of the primary individuals working to keep this area of science exciting and adventurous. His overall contributions to surface science were countless and his contributions to the DIET field and community were enormous. He is missed and remembered by many friends and colleagues throughout the world. The papers collected in this issue cover many of the highlights of DIET XII. Topics include ultrafast electron transfer at surfaces and interfaces, quantum and spatially resolved mapping of surface dynamics and desorption, photon-, electron- and ion-beam induced processes at complex interfaces, the role of non-thermal desorption in astrochemistry and astrophysics and laser-/ion-based methods of examining soft matter and biological media. Although the workshop attracted many scientists active in the general area of non-thermal surface processes, DIET XII also attracted many younger scientists (i.e., postdoctoral fellows, advanced graduate students, and a select number of advanced undergraduate students). This field has had an impact in a number of areas including nanoscience, device physics, astrophysics, and now biophysics. We believe that this special issue of Journal of Physics

Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation

NARCIS (Netherlands)

Stroo, Ingrid; Zeerleder, Sacha; Ding, Chao; Luken, Brenda M.; Roelofs, Joris J. T. H.; de Boer, Onno J.; Meijers, Joost C. M.; Castellino, Francis J.; van 't Veer, Cornelis; van der Poll, Tom

2017-01-01

Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved

Radioimmunoassay of human Hageman factor (factor XII)

International Nuclear Information System (INIS)

Saito, H.; Ratnoff, O.D.; Pensky, J.

1976-01-01

A specific, sensitive, and reproducible radioimmunoassay for human Hageman factor (HF, factor XII) has been developed with purified human HF and monospecific rabbit antibody. Precise measurements of HF antigen were possible for concentrations as low as 0.1 percent of that in normal pooled plasma. A good correlation (correlation coefficient = 0.82) existed between the titers of HF measured by clot-promoting assays and radioimmunoassays among 42 normal adults. Confirming earlier studies, HF antigen was absent in Hageman trait plasma, but other congenital deficient plasmas, including those of individuals with Fletcher trait and Fitzgerald trait, contained normal amounts of HF antigen. HF antigen was reduced in the plasmas of patients with disseminated intravascular coagulation or advanced liver cirrhosis, but it was normal in those of patients with chronic renal failure or patients under treatment with warfarin. HF antigen was detected by this assay in plasmas of primates, but not detectable in plasmas of 11 nonprimate mammalian and one avian species

75 FR 37456 - Green Retrofit Program of Title XII of the American Recovery and Reinvestment Act of 2009

Science.gov (United States)

2010-06-29

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5376-N-55] Green Retrofit Program of... Affordable Housing Preservation must collect certain data to administer the Green Retrofit Program (GRP... Title of Proposal: Green Retrofit Program of Title XII of the American Recovery and Reinvestment Act of...

Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors

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Gozzo A.J.

2003-01-01

Full Text Available Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be influenced by several factors including glycosaminoglycans, as recently demonstrated by our group. The aim of the present study was to investigate the effect of glycosaminoglycans (30 to 250 µg/ml on kallikrein activity on plasminogen and factor XII and on the inhibition of kallikrein by the plasma proteins C1-inhibitor and antithrombin. Almost all available glycosaminoglycans (heparin, heparan sulfate, bovine and tuna dermatan sulfate, chondroitin 4- and 6-sulfates reduced (1.2 to 3.0 times the catalytic efficiency of kallikrein (in a nanomolar range on the hydrolysis of plasminogen (0.3 to 1.8 µM and increased (1.9 to 7.7 times the enzyme efficiency in factor XII (0.1 to 10 µM activation. On the other hand, heparin, heparan sulfate, and bovine and tuna dermatan sulfate improved (1.2 to 3.4 times kallikrein inhibition by antithrombin (1.4 µM, while chondroitin 4- and 6-sulfates reduced it (1.3 times. Heparin and heparan sulfate increased (1.4 times the enzyme inhibition by the C1-inhibitor (150 nM.

Summary of significant solar-initiated events during STIP interval XII

International Nuclear Information System (INIS)

Gergely, T.E.

1982-01-01

A summary of the significant solar-terrestrial events of STIP Interval XII (April 10-July 1, 1981) is presented. It is shown that the first half of the interval was extremely active, with several of the largest X-ray flares, particle events, and shocks of this solar cycle taking place during April and the first half of May. However, the second half of the interval was characterized by relatively quiet conditions. A detailed examination is presented of several large events which occurred on 10, 24, and 27 April and on 8 and 16 May. It is suggested that the comparison and statistical analysis of the numerous events for which excellent observations are available could provide information on what causes a type II burst to propagate in the interplanetary medium

PENGARUH HASIL BELAJAR MATA PELAJARAN PRODUKTIF AKUNTANSI, PROGRAM PRAKTIK KERJA INDUSTRI DAN SELF EFFICACY TERHADAP KESIAPAN KERJA SISWA KELAS XII PROGRAM KEAHLIAN AKUNTANSI DI SMK NEGERI 1 KENDAL TAHUN AJARAN 2013/2014

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Noviana Noviana

2013-02-01

Full Text Available Sekolah Menengah Kejuruan merupakan lembaga pendidikan yang menghasilkan lulusan untuk siap kerja sesuai dengan bidang keahliannya. Kondisi di SMK Negeri 1 Kendal Tahun Ajaran 2012/2013 terdapat 66,67% atau 34 siswa yang bekerja diluar bidang akuntansi. Tujuan penelitian ini untuk mengetahui pengaruh hasil belajar mata pelajaran produktif akuntansi, program praktik kerja industri, dan self efficacy terhadap kesiapan kerja siswa kelas XII program keahlian akuntansi di SMK Negeri 1 Kendal Tahun Ajaran 2013/2014 baik secara parsial maupun simultan. Jenis penelitian ini adalah uji pengaruh dengan pendekatan kuantitatif. Populasi penelitian ini adalah seluruh siswa kelas XII program keahlian akuntansi sejumlah 105 siswa. Metode pengumpulan data menggunakan metode dokumentasi dan metode angket/kuesioner. Metode analisis data menggunakan analisis deskriptif, analisis regresi berganda, uji koefisien determinasi (R2, uji simultan (F, dan uji parameter individual (t. Hasil penelitian ini adalah secara parsial ada pengaruh hasil belajar mata pelajaran produktif akuntansi sebesar 25,70%, program praktik kerja industri sebesar 23,20%, dan self efficacy sebesar 32,90% terhadap kesiapan kerja siswa kelas XII. Sedangkan secara simultan ada pengaruh hasil belajar mata pelajaran produktif akuntansi, program praktik kerja industri, dan self efficacy terhadap kesiapan kerja siswa kelas XII program keahlian akuntansi di SMK Negeri 1 Kendal Tahun Ajaran 2013/2014 sebesar 43,10%. Vocational High School is an educational institution that produces graduates ready to work according to their expertise. Conditions at SMK Negeri 1 Kendal Academic Year 2012/2013 there are 66.67 % or 34 students working beyond the field of accounting The purpose of this study was to determine the effect of the learning outcomes of productive subjects accounting, on the job training program, and self-efficacy on job readiness class XII students accounting skills program at SMK Negeri 1 Kendal

Malaria transmission in Tripura: Disease distribution & determinants.

Science.gov (United States)

Dev, Vas; Adak, Tridibes; Singh, Om P; Nanda, Nutan; Baidya, Bimal K

2015-12-01

Malaria is a major public health problem in Tripura and focal disease outbreaks are of frequent occurrence. The state is co-endemic for both Plasmodium falciparum and P. vivax and transmission is perennial and persistent. The present study was aimed to review data on disease distribution to prioritize high-risk districts, and to study seasonal prevalence of disease vectors and their bionomical characteristics to help formulate vector species-specific interventions for malaria control. Data on malaria morbidity in the State were reviewed retrospectively (2008-2012) for understanding disease distribution and transmission dynamics. Cross-sectional mass blood surveys were conducted in malaria endemic villages of South Tripura district to ascertain the prevalence of malaria and proportions of parasite species. Mosquito collections were made in human dwellings of malaria endemic villages aiming at vector incrimination and to study relative abundance, resting and feeding preferences, and their present susceptibility status to DDT. The study showed that malaria was widely prevalent and P. falciparum was the predominant infection (>90%), the remaining were P. vivax cases. The disease distribution, however, was uneven with large concentration of cases in districts of South Tripura and Dhalai coinciding with vast forest cover and tribal populations. Both Anopheles minimus s.s. and An. baimaii were recorded to be prevalent and observed to be highly anthropophagic and susceptible to DDT. Of these, An. minimus was incriminated (sporozoite infection rate 4.92%), and its bionomical characteristics revealed this species to be largely indoor resting and endophagic. For effective control of malaria in the state, it is recommended that diseases surveillance should be robust, and vector control interventions including DDT spray coverage, mass distribution of insecticide-treated nets/ long-lasting insecticidal nets should be intensified prioritizing population groups most at risk to

Primary sclerosing cholangitis and disease distribution in inflammatory bowel disease.

LENUS (Irish Health Repository)

O'Toole, Aoibhlinn

2012-04-01

The relationship between site of intestinal inflammation and primary sclerosing cholangitis (PSC) development in inflammatory bowel disease (IBD) has not been studied extensively, but may be important in understanding the pathogenesis of PSC. We aimed to determine patterns of disease distribution in IBD patients with and without PSC.

Pengembangan Modul Pembelajaran Fisika Berbasis Problem Based Learning (PBL pada Materi Gelombang Bunyi untuk Siswa SMA Kelas XII

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Tri Anita Nur Hasanah

2017-03-01

Full Text Available The 2013 curriculum emphasizes on Scientific Approach taht tie topic with real context. Either learning model that leads to Scientific Approach that is Problem Based Learning (PBL. So that need to prepare appropriate teaching material to support learning model PBL one of them module independent teaching topic for learners. The aim of these research is describe the Learning Module which is developed that is physic learning module based on PBL of the topic sound wave for senior high school grade XII and examine its feasibility. This development research used 4-D Thiagarajan with modified model. This research has been done in three stages such as define, design, and develop which are restricted until the limited try out. The data collection is used questionnaire. The module validation by 4 validators and limited try out to 10 students. The result of research drawn that material aspect is 3,59 with the suitable criterion, presentation aspect is 3,9 with the suitable criterion, language aspect is 3,41 with the suitable criterion, and the limited try out result got 3,6 with an appropriate criterion. In conclusion, physic learning module based on PBL in sound wave material for senior high school grade XII is applicable. Keywords: Physic Learning Module, Problem Based Learning (PBL, Topic sound wave Pada kurikulum 2013 menekankan pada Scientific Approach yang mengaitkan materi dengan konteks dunia nyata. Salah satu model pembelajaran yang mengarah ke Scientific Approach yaitu Problem Based Learning (PBL. Sehingga perlu dipersiapkan bahan ajar yang tepat untuk mendukung model pembelajaran PBL salah satunya modul yang merupakan bahan ajar mandiri bagi peserta didik. Tujuan penelitian ini adalah mendeskripsikan pengembangan modul yaitu modul pembelajaran fisika berbasis PBL pada materi Gelombang Bunyi untuk siswa SMA kelas XII dan menguji kelayakannya.Penelitian pengembangan menggunakan model 4-D Thiagarajan yang sudah di modifikasi. Penelitian ini

Distributed Market-Based Algorithms for Multi-Agent Planning with Shared Resources

Science.gov (United States)

2013-02-01

1 Introduction 1 2 Distributed Market-Based Multi-Agent Planning 5 2.1 Problem Formulation...over the deterministic planner, on the “test set” of scenarios with changing economies. . . 50 xi xii Chapter 1 Introduction Multi-agent planning is...representation of the objective (4.2.1). For example, for the supply chain mangement problem, we assumed a sequence of Bernoulli coin flips, which seems

PENGARUH PELAKSANAAN OJT (ON THE JOB TRAINING DAN PERAN ORANGTUA TERHADAP MINAT BERWIRAUSAHA PADA SISWA KELAS XII KOMPETENSI KEAHLIAN AKUNTANSI DI SMK NEGERI 2 SEMARANG TAHUN AJARAN 2013/2014

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Siti Mutmainah

2013-11-01

Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh OJT (On The Job Training dan peran orangtua terhadap minat berwirausaha pada siswa kelas XII Kompetensi Keahlian Akuntansi di SMK Negeri 2 Semarang tahun ajaran 2013/2014. Populasi dalam penelitian adalah seluruh siswa kelas XII kompetensi keahlian akuntansi SMK Negeri 2 Semarang sebanyak 108 siswa dan sampel dalam penelitian adalah seluruh populasi yang berjumlah 108 siswa. Metode pengump ulan data yang digunakan adalah metode kuesioner. Metode analisis data yang digunakan yaitu analisis deskriptif dan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa ada pengaruh positif antara OJT dan peran orangtua terhadap minat berwi rausaha. Hasil penelitian diperoleh persamaan regresi linier berganda yaitu Y = 27,396+0,233X 1+0,892X2 +e. Kontribusi OJT dan peran orangtua terhadap minat berwirausaha secara silmutan sebesar 29,8%. Besarnya pengaruh secara parsial variabel OJT sebesar 4,54% dan besarnya pengaruh secara parsial variabel peran orangtua sebesar 16,08%. Berdasarkan hasil penelitian disimpulkan bahwa ada pengaruh OJT dan peran orangtua terhadap minat berwirausaha siswa kelas XII kompetensi keahlian akuntansi SMK Negeri 2 Semara ng tahun ajaran 2013/2014 baik secara simultan maupun parsial. This research has purpose for knowing effect of OJT (On The Job Training and parent’s fungtion toward interesting in entrepreneurship simultaneously and partially students class XII accounting skills competence in Vocational High School State 2 Semarang year 2013/2014. The population of this research is all students class XII accounting skills comp etence in Vocational High School State 2 Semarang as many as 108 students and sample of this research is all of population as many as 108 students. Data collection method was used a questionnaire method. Data collection method was used a questionnaire method. Method of data analysis is descriptive analysis and multiple regression analysis. The

XII All-Russian conference Diagnostics of high-temperature plasma. Abstracts of reports and conference program

International Nuclear Information System (INIS)

2007-01-01

Abstracts of reports made on the XII All-Russian conference on high-temperature plasma diagnostics are presented. The different methods of hot plasma diagnostics are considered, namely microwave diagnostic methods, laser diagnostic techniques, X-ray plasma diagnostics and corpuscular diagnostic methods. The particular attention is given to wall plasma diagnostics and diagnostics of inertial synthesis systems. Current diagnostic tools and metrological provision for plasma diagnostics are considered. The diagnostic complexes of thermonuclear devices are described. The problems of experimental data processing are discussed [ru

XII International Conference on the Theory of Machines and Mechanisms

CERN Document Server

Bílek, Martin; Žabka, Petr

2017-01-01

This book presents the most recent advances in the research of machines and mechanisms. It collects 54 reviewed papers presented at the XII International Conference on the Theory of Machines and mechanisms (TMM 2016) held in Liberec, Czech Republic, September 6-8, 2016. This volume offers an international selection of the most important new results and developments, grouped in six different parts, representing a well-balanced overview, and spanning the general theory of machines and mechanisms, through analysis and synthesis of planar and spatial mechanisms, linkages and cams, robots and manipulators, dynamics of machines and mechanisms, rotor dynamics, computational mechanics, vibration and noise in machines, optimization of mechanisms and machines, mechanisms of textile machines, mechatronics to the control and monitoring systems of machines. This conference is traditionally organised every four year under the auspices of the international organisation IFToMM and the Czech Society for Mechanics.

The GEKKO XII-HIPER (High Intensity Plasma Experimental Research) system relevant to ignition targets

International Nuclear Information System (INIS)

Miyanaga, N.; Nakatsuka, M.; Azechi, H.

2001-01-01

To test high gain targets surrogated in the planar geometry, we have constructed a new experimental system (HIPER) which provides the high ablation pressure with a uniform irradiance profile. These performances were achieved by bundling twelve beams of the existing GEKKO XII into a F/3 focus cone. The partially coherent light is introduced for the beam smoothing of a green foot pulse consisting of three beams, and the three-directional smoothing by spectral dispersion is utilized for residual nine beams delivering a blue main drive pulse. The detail of design concept and results of initial activation of this system are reported. (author)

'Candidatus Phytoplasma solani', a novel taxon associated with stolbur- and bois noir-related diseases of plants.

Science.gov (United States)

Quaglino, Fabio; Zhao, Yan; Casati, Paola; Bulgari, Daniela; Bianco, Piero Attilio; Wei, Wei; Davis, Robert Edward

2013-08-01

Phytoplasmas classified in group 16SrXII infect a wide range of plants and are transmitted by polyphagous planthoppers of the family Cixiidae. Based on 16S rRNA gene sequence identity and biological properties, group 16SrXII encompasses several species, including 'Candidatus Phytoplasma australiense', 'Candidatus Phytoplasma japonicum' and 'Candidatus Phytoplasma fragariae'. Other group 16SrXII phytoplasma strains are associated with stolbur disease in wild and cultivated herbaceous and woody plants and with bois noir disease in grapevines (Vitis vinifera L.). Such latter strains have been informally proposed to represent a separate species, 'Candidatus Phytoplasma solani', but a formal description of this taxon has not previously been published. In the present work, stolbur disease strain STOL11 (STOL) was distinguished from reference strains of previously described species of the 'Candidatus Phytoplasma' genus based on 16S rRNA gene sequence similarity and a unique signature sequence in the 16S rRNA gene. Other stolbur- and bois noir-associated ('Ca. Phytoplasma solani') strains shared >99 % 16S rRNA gene sequence similarity with strain STOL11 and contained the signature sequence. 'Ca. Phytoplasma solani' is the only phytoplasma known to be transmitted by Hyalesthes obsoletus. Insect vectorship and molecular characteristics are consistent with the concept that diverse 'Ca. Phytoplasma solani' strains share common properties and represent an ecologically distinct gene pool. Phylogenetic analyses of 16S rRNA, tuf, secY and rplV-rpsC gene sequences supported this view and yielded congruent trees in which 'Ca. Phytoplasma solani' strains formed, within the group 16SrXII clade, a monophyletic subclade that was most closely related to, but distinct from, that of 'Ca. Phytoplasma australiense'-related strains. Based on distinct molecular and biological properties, stolbur- and bois noir-associated strains are proposed to represent a novel species level taxon, 'Ca

Multi-choice stochastic transportation problem involving general form of distributions.

Science.gov (United States)

Quddoos, Abdul; Ull Hasan, Md Gulzar; Khalid, Mohammad Masood

2014-01-01

Many authors have presented studies of multi-choice stochastic transportation problem (MCSTP) where availability and demand parameters follow a particular probability distribution (such as exponential, weibull, cauchy or extreme value). In this paper an MCSTP is considered where availability and demand parameters follow general form of distribution and a generalized equivalent deterministic model (GMCSTP) of MCSTP is obtained. It is also shown that all previous models obtained by different authors can be deduced with the help of GMCSTP. MCSTP with pareto, power function or burr-XII distributions are also considered and equivalent deterministic models are obtained. To illustrate the proposed model two numerical examples are presented and solved using LINGO 13.0 software package.

STUDI KOMPARASI SELF CONTROL SISWA YANG MEMILIKI KECERDASAN SPIRITUAL TINGGI DAN RENDAH DI KELAS XII SMAN I KOTA KEDIRI TAHUN PELAJARAN 2013/2014

Directory of Open Access Journals (Sweden)

Ady Alfan Mahmudinata

2016-07-01

Full Text Available Referring to the character of the Education Act in Indonesia listed in Act 20 of 2003 on National Education System Indonesia Article: 1 The purpose of national education to develop the potential of learners to have the intelligence, personality, and noble character; and article 3, paragraph 1: National education serves to develop the ability and shape the character and civilization of the nation's dignity in the context of national life as well as you view the proyeksitas Islamic religious education that is feeding religious spiritual student-related non- Islamic values are synergistic against strong self control gaining control himself strong for the students, for the writer interested to learn and find out about the intelligence level of spiritual and differences self Control students, among students who have spiritual intelligence of high and low class XII SMAN I Kediri, with the formulation of the problem 1 What is the level of intelligence spiritual students ? 2 How Self Control students who have high spiritual intelligence? 3 How Self Control students who have low spiritual intelligence? 4 Do Self Control students who have high spiritual intelligence is stronger than the Self Control students who have low spiritual intelligence?This study uses a mixed method approach. The data collection was conducted by questionnaire, documentation, interviews and observation. The population of this research is class XII student of SMAN I Kediri. Sampling starts with random sampling techniques on Muslim students in class XII and generalized according to the level of intelligence Spiritual owned. Statistical data analysis with independent t-test formula. The research sample for the group of students who have Spiritual intelligence is as many as 152 students were taken based on Table Krejcie for error rate ( of 0.05 of the total students totaling 250 students, from 152 students after given a rating based on spiritual intelligence instrument  then found the

Modelling the distribution of pig production and diseases in Thailand

OpenAIRE

Thanapongtharm, Weerapong

2015-01-01

This thesis, entitled “Modelling the distribution of pig production and diseases in Thailand”, presents many aspects of pig production in Thailand including the characteristics of pig farming system, distribution of pig population and pig farms, spatio-temporal distribution and risk of most important diseases in pig at present, and the suitability area for pig farming. Spatial distribution and characteristics of pig farming in Thailand were studied using time-series pig population data to des...

Observation of solar radio bursts of type II and III at kilometer wavelengths from Prognoz-8 during STIP Interval XII

International Nuclear Information System (INIS)

Pinter, S.; Kecskemety, K.; Kudela, K.

1982-04-01

Type II and type III radio events were observed at low frequencies (2.16 MHz to 114 kHz) by the Prognoz-8 satellite during the period of STIP Interval XII in April and May, 1981, respectively. This review covers briefly a chronology of the sub-megahertz radio events, and where possible their association with both groundbased radio observations and solar flare. (author)

KETERAMPILAN MENULIS KREATIF CERPEN MENGGUNAKAN MEDIA AUDIO SISWA KELAS XII SMAN 1 KECAMATAN PAYAKUMBUH

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Wirda Linda

2017-04-01

Full Text Available Writing skills is activities of language serves to produce  written language. Writing can improve intelligence, develop initiative, creativity,, stimulate the willingness and ability to gather information. Students' skills in short stories writing activities is still lacking. This things because teachers use less attractive media. Thus, this study uses audio media to increase students' interest in writing. This study aimed to describe the shost story intrinsic elements and the use of capital letters in Creative Short Story Writing Skills Using Media Audio Class XII SMAN I Payakumbuh District.This research is a quantitative research using descriptive method. The study population class XII students totaling 217 consists of 8 classes. Writer to perform sampling with random random sampling techniques. The instrument of this study is to test performance. Data analysis  in the study: to check the results to write short stories, analyze the data and provide a score based on indicators, and put forward the test results to the classification skills by using a scale of 10.Results showed that  average value of 90.8 are in the range of 86-95% with good qualification. Creative writing skills are evaluated from two short stories specified indicators are: (1 short story creative writing skills in terms of the intrinsic elements of the short story is the 100 that are in the range of 96-100% with impeccable qualifications; (2 The short story creative writing skills in terms of capitalization was 80.8% are in the 76-85 range with good qualifications. Thus, we can conclude the students are already capable in writing short stories as well as the use of capital letters in writing.    

Geothermal Program Review XII: proceedings. Geothermal Energy and the President's Climate Change Action Plan

Energy Technology Data Exchange (ETDEWEB)

1994-12-31

Geothermal Program Review XII, sponsored by the Geothermal Division of US Department of Energy, was held April 25--28, 1994, in San Francisco, California. This annual conference is designed to promote effective technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal energy developers; suppliers of geothermal goods and services; representatives from federal, state, and local agencies; and others with an interest in geothermal energy. In-depth reviews of the latest technological advancements and research results are presented during the conference with emphasis on those topics considered to have the greatest potential to impact the near-term commercial development of geothermal energy.

77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

Science.gov (United States)

2012-05-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-68-000] Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC, Alta Wind XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower Development, LLC, TGP Development Company, LLC...

Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome

International Nuclear Information System (INIS)

Yoo, Chong Woo; Nam, Byung-Ho; Kim, Joo-Young; Shin, Hye-Jin; Lim, Hyunsun; Lee, Sun; Lee, Su-Kyoung; Lim, Myong-Cheol; Song, Yong-Jung

2010-01-01

To investigate whether expression of carbonic anhydrase XII (CA12) is associated with histologic grade of the tumors and radiotherapy outcomes of the patients with invasive cervical cancer. CA12 expression was examined by immunohistochemical stains in cervical cancer tissues from 183 radiotherapy patients. Histological grading was classified as well (WD), moderately (MD) or poorly differentiated (PD). Oligonucleotide microarray experiment was performed using seven cervical cancer samples to examine differentially expressed genes between WD and PD cervical cancers. The association between CA12 and histological grade was analyzed by chi-square test. CA12 and histological grades were analyzed individually and as combined CA12 and histologic grade categories for effects on survival outcome. Immunohistochemical expression of CA12 was highly associated with the histologic grade of cervical cancer. Lack of CA12 expression was associated with PD histology, with an odds ratio of 3.9 (P = 0.01). Microarray analysis showed a fourfold reduction in CA12 gene expression in PD tumors. CA12 expression was marginally associated with superior disease-free survival. Application of the new combined categories resulted in further discrimination of the prognosis of patients with moderate and poorly differentiated tumor grade. Our study indicates that CA12 may be used as a novel prognostic marker in combination with histologic grade of the tumors

EFEKTIVITAS METODE DRILL BERBANTUAN MODUL PEMBELAJARAN DALAM UPAYA MENINGKATKAN HASIL BELAJAR SISWA KOMPETENSI DASAR JURNAL KHUSUS PERUSAHAAN DAGANG PADA SISWA KELAS XII IPS SMA NEGERI 10 SEMARANG TAHUN AJARAN 2013/2014

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Meta Aditya Handayani

2013-11-01

Full Text Available Tujuan penelitian untuk mengetahui penerapan metode drill berbantuan modul dapat meningkatkan hasil belajar akuntansi kompetensi dasar Jurnal Khusus kelas XII IPS SMA Negeri 10 Semarang tahun ajaran 2013/2014 . Penelitian ini menggunakan metode quasi eksperimen. Populasi dalam penelitian ini adalah seluruh kelas XII IPS SMA Negeri 10 Semarang Tahun Ajaran 2013/2014. Metode pengumpulan data yaitu dengan menggunakan tes dan observasi. Pengujian hipotesis menggunakan uji paired sample t-tets dan independent sample t-test. Hasil penelitian menunjukkan peningkatan hasil belajar pada kelas eksperimen dilihat dari 61,16 meningkat mencapai 80,89. Selain itu menunjukkan hasil rata-rata nilai post-test sebesar 80,89 pada kelas eksperimen lebih tinggi dibandingkan nilai post-test sebesar 77,29 pada kelas kontrol. Berdasarkan hasil penelitian dapat disimpulkan bahwa pembelajaran dengan menggunakan metode pembelajaran drill berbantuan modul dapat meningkatkan hasil belajar serta efektif dalam meningkatkan hasil belajar siswa k ompetensi dasar jurnal khusus. Research purposes to determine the application of assisted modules drill method to improve learning outcomes of accounting competence base class XII IPS Special Journal SMA Negeri 10 Semarang school year 2013/2014. This study uses a quasi-experimental methods. The population in this study were all class XII IPS SMA Negeri 10 Semarang Academic Year 2013/2014. Data collection method is by using tests and observation. Hypothesis testing using paired sample t-tets and independent sample t-test. Results showed improved learning outcomes seen in the experimental classes increased to 80.89 from 61.16. In addition it shows the results of the average post-test score of 80.89 in the experimental class higher than the post -test score of 77.29 in the control class. Based on the results of this study concluded that learning by using drill -assisted learning modules to improve learning outcomes and effective in imp

Castillos, poder feudal y reorganización espacial en la Transierra madrileña (siglos XII-XIII

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Iñaki Martín Viso

2000-01-01

Full Text Available Algunos castillos de la Transierra madrileña en los siglos xii y xiii son herederos de los husün musulmanes, pero se convierten en esa época en centros de poder señorial sobre unas débiles comunidades. No obstante, sólo su transformación en concejos permitirá la supervivencia de algunos de ellos, aunque se observa también un desplazamiento del habitat hacia el llano, resultado de la formación de un nuevo sistema productivo basado en la agricultura cerealfstica y la propiedad feudal, por lo que el papel de los castillos es limitado. En las zonas serranas su relevancia es aún menor y nunca estructuraron el paisaje, labor que ejercieran los sexmos de la Tierra de Segovia.Some castles of the Madrid's Transierra in the xii"" and xiif" centuries are inheritors of the muslim husün, but they viere converted during this age in centres of a lordship power which was imposed to the weak communities. However, only some of them could survive through their conversión In town counciis (concejos, although there is also an habitat's displacement to the plain, that is the result of the new producing system based on the grain agrículture and the feudal property, so the role of the castles was reduced. In the mountain áreas the landscape was never structured by castles, but by the rural distrícts (sexmos ofthe Segovia's Land.

Lyme Disease in West Virginia: An Assessment of Distribution and Clinicians' Knowledge of Disease and Surveillance.

Science.gov (United States)

Singh, Sarah; Parker, David; Mark-Carew, Miguella; White, Robert; Fisher, Melanie

2016-01-01

Lyme disease case misclassification, a top public health concern, may be attributed to the current disconnect between clinical diagnosis and surveillance. This study examines Lyme disease distribution in West Virginia (WV) and determines clinicians' knowledge of both disease and surveillance. Lyme disease surveillance data for 2013 were obtained from the WV Bureau for Public Health. A validated survey, distributed to clinicians at an academic medical center, assessed clinicians' knowledge of disease diagnosis and surveillance. There were 297 adult Lyme disease cases of which 83 were confirmed. Clinician survey responses resulted in a correct response rate of 70% for Lyme disease knowledge questions. Fewer than half of all clinicians were aware of the surveillance criteria for confirming Lyme disease cases. Neither medical specialty nor previous treatment of patients with Lyme disease were significantly associated with clinicians' knowledge of the disease. Clinicians in WV are familiar with symptoms and clinical management of Lyme disease. However, they are less knowledgeable about diagnosis and public health surveillance comprising reporting and confirming cases of the disease. Clinicians and public health authorities should collaborate more closely to promote education and awareness as a key step to successfully reducing the burden of Lymne disease.

Pembelajaran Fisika Berbasis Kompetensi Life Skill Kelas XII IPA.1 MAN 1 Lampung Selatan

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Poniman Poniman

2016-04-01

Full Text Available This study aims to determine the physics competency-based learning life skills class XII IPA1, It conducted in two cycles, each cycle consisting of four phases: planning, execution, analysis and reflection. The action used is "Competency-Based Physics Education Life Skills". The first cycle has not succeeded cognitive aspects obtained a mean value of 5.62, the affective with good criterion 32.35%, sufficient criteria 67.65% as well as psychomotor with good criterion 38.34%, sufficient criteria 61.66%, the life skill with all criteria 41.18%, both criteria 58.82 %.The second trying to provide intensive training with the same material, the result of learning on the cognitive of a mean value of 5.81, affective with both criteria of 76.47%, sufficient criteria 23.53%, psychomotor with good criterion 55.88%, sufficient criteria of 44.12% as well as on the life skill with very good criteria 1.76%. Penelitian ini bertujuan untuk mengetahui dampak pembelajaran fisika berbasis kompetensi life skill pada kelas XII IPA1. Penelitian ini dilakukan dalam dua siklus, setiap siklus terdiri dari empat tahap: perencanaan, pelaksanaan, analisis dan refleksi. Tindakan yang digunakan adalah "Pembelajaran isika Berbasis Kompetensi Life Skills ". Siklus pertama belum berhasil, nilai rata-rata aspek kognitif diperoleh 5,62; afektif dengan kriteria baik 32,35%, dan kriteria cukup 67,65%; serta psikomotorik dengan kriteria baik 38,34%, dan kriteria cukup 61.66%; life skills dengan semua kriteria 41,18%, kriteria baik 58,82%. siklus kedua mencoba untuk memberikan pelatihan intensif dengan tindakan yang sama, rata-rata hasil belajar aspek kognitif 5,81; afektif dengan kriteria baik 76,47%, kriteria cukup 23,53% , psikomotor dengan kriteria baik 55,88%, kriteria cukup 44,12% serta pada life skill dengan kriteria baik sekali 1,76%. Kata kunci: pembelajaran fisika, physics competency-based learning life skills

A domus infirmorum do mosteiro de Santa Cruz de Coimbra e o acolhimento no hospital São Nicolau (Portugal, séculos XII-XIII

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Dulce O. Amarante dos Santos

2015-06-01

Full Text Available Este artigo configura os primeiros resultados de uma pesquisa de micro-história sobre dois espaços de saúde e practica médica no Mosteiro agostiniano de Santa Cruz de Coimbra, a saber, a enfermaria ou domus infirmorume o Hospital São Nicolau. O primeiro, construído no século XII, constituiu-se na área do mosteiro crúzio destinada ao cuidado com os monges doentes, definido primeiro nas regras de fundação e depois presente nos Costumeiros ou Liberordinis posteriores. O Hospital São Nicolau foi igualmente fundado em meados do século XII e funcionou como os outros hospitais de caridade medieval, ou seja, hospedava peregrinos, albergava pobres, tratava dos doentes e acolhia desvalidos. Esses dois espaços favoreceram os estudos médicos, como atestam os títulos da biblioteca, ao mesmo tempo foram lócus de experimentação das medidas preventivas e de práticas terapêuticas.

Evaluation of thromboelastography in two factor XII-deficient cats.

Science.gov (United States)

Blois, Shauna L; Holowaychuk, Marie K; Wood, R Darren

2015-01-01

The current report describes thromboelastography (TEG) findings in two cats with factor XII (FXII) deficiency. The first cat was diagnosed with bilateral perinephric pseudocysts; hemostatic testing was performed prior to performing renal aspirates. The second cat was healthy; hemostatic testing was performed prior to inclusion into a research project. Both cats had markedly prolonged partial thromboplastin times and hypocoagulable TEG tracings when samples were activated with kaolin. However, when tissue factor (TF) was used to activate the sample, both cats had normal-to-hypercoagulable TEG tracings. The cats each had a subnormal FXII level. TEG is becoming widely used to investigate hemostasis in veterinary patients, and TEG results in cats with FXII deficiency have not been previously reported. FXII deficiency is the most common hereditary hemostatic defect in cats. While FXII deficiency does not lead to in vivo hemorrhagic tendencies, it can lead to marked prolongation in activated partial thromboplastin and activated clotting times, and cannot be differentiated from true hemorrhagic diatheses without measuring individual factor activity. With the increased use of TEG to evaluate hemostasis in veterinary patients, it is important to recognize the effects of FXII deficiency on this testing modality. The finding of a hypocoagulable kaolin-activated TEG tracing and a concurrent normal TF-activated TEG tracing in samples should prompt clinicians to consider ruling out FXII deficiency.

Evaluation of thromboelastography in two factor XII-deficient cats

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Shauna L Blois

2015-05-01

Full Text Available Case summary The current report describes thromboelastography (TEG findings in two cats with factor XII (FXII deficiency. The first cat was diagnosed with bilateral perinephric pseudocysts; hemostatic testing was performed prior to performing renal aspirates. The second cat was healthy; hemostatic testing was performed prior to inclusion into a research project. Both cats had markedly prolonged partial thromboplastin times and hypocoagulable TEG tracings when samples were activated with kaolin. However, when tissue factor (TF was used to activate the sample, both cats had normal-to-hypercoagulable TEG tracings. The cats each had a subnormal FXII level. Relevance and novel information TEG is becoming widely used to investigate hemostasis in veterinary patients, and TEG results in cats with FXII deficiency have not been previously reported. FXII deficiency is the most common hereditary hemostatic defect in cats. While FXII deficiency does not lead to in vivo hemorrhagic tendencies, it can lead to marked prolongation in activated partial thromboplastin and activated clotting times, and cannot be differentiated from true hemorrhagic diatheses without measuring individual factor activity. With the increased use of TEG to evaluate hemostasis in veterinary patients, it is important to recognize the effects of FXII deficiency on this testing modality. The finding of a hypocoagulable kaolin-activated TEG tracing and a concurrent normal TF-activated TEG tracing in samples should prompt clinicians to consider ruling out FXII deficiency.

Soft x-ray amplification in lithium-like Al XI (154 /angstrom/) and Si XII (129 /angstrom/)

International Nuclear Information System (INIS)

Kim, D.; Skinner, C.H.; Wouters, A.; Valeo, E.; Voorhees, D.; Suckewer, S.

1988-03-01

Recent experiments on soft x-ray amplification in lithium-like ions in a CO 2 laser-produced recombining plasma confined in a magnetic field are presented. The maximum gain-length products observed are GL ≅ 3 to 4 for the 154 /angstrom/, 4f-3d transition in Al XI and GL (approxreverse arrowequal/ 1 to 2 for the 129 /angstrom/, 4f-3d transition in Si XII, respectively. A one-dimensional hydrodynamic code with a collisional-radiative atomic model was used to model the plasma and the theoretical predictions of gain agree well with the observations. Descriptions of both hydrodynamic and atomic physics code are given. 36 refs., 10 figs

Hegel y Aristóteles: Una lectura de Metafísica XII, 7,1072b 18-30

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Luis Xavier López-Farjeat

2013-11-01

Full Text Available The author does a hegelian interpretation of Metaphysics XII, 7, 1072b 18-30, passage with which the Encyclopedia of the Philosophical Sciences concludes. Here are drawn the relations and similitudes that exist between Aristotle's Unmoved Mover and Hegel's Absolute. In order to understand in which points both thinkers coincide when describing divine thought, it is highly important to analyze the notions of thought, movement, power, act, concept, object, material substance, formal substance and suprasensible substance. The interpretative turn that Hegel does of Metaphysics and the comparative reading here offered, point towards a better understanding of the nature of the Unmoved Mover and the Absolute.

The lower cranial nerves: IX, X, XI, XII.

Science.gov (United States)

Sarrazin, J-L; Toulgoat, F; Benoudiba, F

2013-10-01

The lower cranial nerves innervate the pharynx and larynx by the glossopharyngeal (CN IX) and vagus (CN X) (mixed) nerves, and provide motor innervation of the muscles of the neck by the accessory nerve (CN XI) and the tongue by the hypoglossal nerve (CN XII). The symptomatology provoked by an anomaly is often discrete and rarely in the forefront. As with all cranial nerves, the context and clinical examinations, in case of suspicion of impairment of the lower cranial nerves, are determinant in guiding the imaging. In fact, the impairment may be located in the brain stem, in the peribulbar cisterns, in the foramens or even in the deep spaces of the face. The clinical localization of the probable seat of the lesion helps in choosing the adapted protocol in MRI and eventually completes it with a CT-scan. In the bulb, the intra-axial pathology is dominated by brain ischemia (in particular, with Wallenberg syndrome) and multiple sclerosis. Cisternal pathology is tumoral with two tumors, schwannoma and meningioma. The occurrence is much lower than in the cochleovestibular nerves as well as the leptomeningeal nerves (infectious, inflammatory or tumoral). Finally, foramen pathology is tumoral with, outside of the usual schwannomas and meningiomas, paragangliomas. For radiologists, fairly hesitant to explore these lower cranial pairs, it is necessary to be familiar with (or relearn) the anatomy, master the exploratory technique and be aware of the diagnostic possibilities. Copyright © 2013 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

PEMANFAATAN FACEBOOK DALAM KETERAMPILAN MEMPRODUKSI TEKS CERITA SEJARAH PADA SISWA KELAS XII IPS-1 SMA NEGERI 3 BOJONEGORO TAHUN PELAJARAN 2015/2016

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Susanto Susanto

2015-12-01

Full Text Available Facebook already familiar among students, thus giving rise to problems in the form of formulation of the problem. How harness, effectiveness studies, and student learning outcomes associated with social media media (facebook in improving the learning skills to produce historical narrative text in class XII IPS 1SMAN 3 Bojonegoro academic year 2015/2016? The method in use is the method of data collection in the form of questionnaires and interviews, and observations during the study (good attitude, knowledge and skills. Results of the research in this paper indicate that Facebook utilize media based learning as e-learning will be developed along technology. The learned very look fabulous. Students of class XII IPS -1 amounted to 32 students. Students who scored above 79 to as many as 27 students or equal to 84.4%. This means that students experiencing learning completeness. While students who scored below 79 or 78 down as much as 5 students, equivalent to 15.6%. Means there are five students who did not complete the work TCS.Saran in this study should be a teacher, the use of FB as a learning medium based e-learning, especially in order to improve the achievement of learning outcomes.

Efecto de un Programa de Capacitación sobre el Clima Organizacional en la Zona Registral N° XII. Arequipa, 2016

OpenAIRE

Herrera Florez, Marcela

2017-01-01

La presente investigación tiene como finalidad realizar el estudio del estado en que se encuentra el clima organizacional en la Zona Registral N° XII; Sede Arequipa, capacitar al personal en temas relacionados con la mejora del clima organizacional y evaluar a los trabajadores luego de las capacitaciones impartidas. La hipótesis a comprobarse fue: es probable que el programa de capacitación “Desarrollo de Competencias de Dirección” mejorará el clima organizacional en los trabajadores de la...

Franklin Roosevelt, Pius XII, Joseph Stalin and the Problem of the USSR’s Image and Reputation During the Second World War

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Filippov Boris

2016-08-01

Full Text Available The aggression of Hitler’s Germany against the USSR made our country an ally of the United States and Great Britain. But the decision to help USSR with weapons and hardware (the lend-lease act faced opposition not only from the American isolationists but also from religious groups. Both Catholics and Protestants were against the very idea of helping the country in which churches were destroyed and the faithful were persecuted. They have considered such an idea to be immoral. To overcome the opposition in Congress, president F. D. Roosevelt and the US diplomats tried to convince Stalin to reject his policies of religious oppression. Roosevelt also asked pope Plus XII for help. At the same time German and Italian ambassadors were trying to convince the Pope to support their “crusade against the godless Bolshevik Russia”. The question of USSR’s image was an important issue throughout the course of war. The article tells the history of the most signifi cant efforts undertaken by the Western allies and Stalin to improve the international reputation of the USSR. First of all, it tells the story of the mysterious letter from Stalin to Plus XII (1942 and about even more mysterious visit of the American priest Stanislav Orlemansky to Moscow and his meeting with Stalin in 1944.

Effects of the infectious period distribution on predicted transitions in childhood disease dynamics.

Science.gov (United States)

Krylova, Olga; Earn, David J D

2013-07-06

The population dynamics of infectious diseases occasionally undergo rapid qualitative changes, such as transitions from annual to biennial cycles or to irregular dynamics. Previous work, based on the standard seasonally forced 'susceptible-exposed-infectious-removed' (SEIR) model has found that transitions in the dynamics of many childhood diseases result from bifurcations induced by slow changes in birth and vaccination rates. However, the standard SEIR formulation assumes that the stage durations (latent and infectious periods) are exponentially distributed, whereas real distributions are narrower and centred around the mean. Much recent work has indicated that realistically distributed stage durations strongly affect the dynamical structure of seasonally forced epidemic models. We investigate whether inferences drawn from previous analyses of transitions in patterns of measles dynamics are robust to the shapes of the stage duration distributions. As an illustrative example, we analyse measles dynamics in New York City from 1928 to 1972. We find that with a fixed mean infectious period in the susceptible-infectious-removed (SIR) model, the dynamical structure and predicted transitions vary substantially as a function of the shape of the infectious period distribution. By contrast, with fixed mean latent and infectious periods in the SEIR model, the shapes of the stage duration distributions have a less dramatic effect on model dynamical structure and predicted transitions. All these results can be understood more easily by considering the distribution of the disease generation time as opposed to the distributions of individual disease stages. Numerical bifurcation analysis reveals that for a given mean generation time the dynamics of the SIR and SEIR models for measles are nearly equivalent and are insensitive to the shapes of the disease stage distributions.

Stroke prevention--a population screening day in district XII of Budapest.

Science.gov (United States)

Folyovich, András; Bakos, Mária; Kántor, Zita; Hertelendy, Anna; Horváth, Eszter; Zsiga, Katalin; Lakatos, Henriette; Vadasdi, Károly

2012-03-30

Along with advances in the treatment of acute stroke, new efforts have been made to enhance efficiency of the prevention of cerebrovascular diseases. Population screening is a way to contact high-risk patients, and there is an increasing international and national experience with the procedure. However, efforts are associated with high costs, so an efficient method, complying with local features, should be selected from the various methods. A stroke prevention day was organized in Szent János Hospital, localized in district XII, and data were analyzed. Taking advantage of the potentials of a large hospital, a comprehensive risk assessment - within the capacity of health care workers - was performed. Program and contact information of the screening day was published in the local newspaper of the district. Data of 48 residents of the district were analyzed. In addition to neurologists, a radiologist, a cardiologist and an ophtalmologist, as well as health care workers were involved in the project. A data sheet was filled in for all participants, including known risk factors, BMI, blood pressure and serum cholesterol levels. All participants had duplex sonography of the cervical vessels, cardiac evaluation and ophtalmic examination. Data were analyzed anonymously, and - if participants approved - postcode and educational level were also recorded. Among the 48 individuals screened, 35 were female and 13 were male. Average age was 62.86 (+/- 8.57) years, and participants were typically of higher educational level. 5 individuals had no known risk factors, most of them had 2-3 risk factors, and multiple risk factors were not uncommon. Individuals with six and seven risk factors were also found. 20 of 27 patients with known hypertension had target blood pressure levels. By duplex sonography, 36 individuals had mild, 4 had significant atherosclerosis. There was no significant carotid stenosis or occlusion. Based on ophtalmic evaluation, 26 patients had signs of vascular

HUBUNGAN PENGALAMAN PRAKTIK KERJA INDUSTRI DAN PRESTASI BELAJAR KEJURUAN DENGAN MINAT BERWIRAUSAHA SISWA KELAS XII TKR SMK COKROAMINOTO 2 BANJARNEGARA TAHUN PELAJARAN 2015/2016

OpenAIRE

Bayu Sandhi Pamungkas; Pairun Roniwijaya

2016-01-01

The Relationship of Practices Industry Experience and Vocational Learning Achievement with Interest in Entrepreneurship Class XII TKR student of  SMK Cokroaminoto 2 Banjarnegara  academic year 2015/2016. Thesis Study Program of Mechanical Engineering Faculty of Teacher Training and Educational Sciences Sarjanawiyata Tamansiswa University Yogyakarta 2016. The purpose of this research is: (1) to determine the relationship of Industry Experience Working Practices with interest in entreprenue...

National Library of Norway's new database of 22 manuscript maps concerning the Swedish King Charles XII's campaign in Norway in 1716 and 1718

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Benedicte Gamborg Brisa

2003-03-01

Full Text Available The National Library of Norway is planning to digitise approximately 1,500 manuscript maps. Two years ago we started working on a pilot project, and for this purpose we chose 22 maps small enough to be photographed in one piece. We made slides 6 x 7 cm in size, converted the slides into PhotoCDs and used four different resolutions on JPEG-files. To avoid large file sizes, we had to divide the version with the biggest resolution into four pieces. The preliminary work was done in Photoshop, the database on the web is made in Oracle. You can click on the map to zoom. Norwegians and probably Swedes during the Great Northern War drew the 22 maps when the Swedish King Charles XII in 1716 and 1718 unsuccessfully attempted to conquer Norway. The database is now accessible on the National Library of Norway's web site. The database is in Norwegian, but we are working on an English version as well. The maps are searchable on different topics, countries, counties, geographical names, shelfmarks or a combination of these. We are planning to expand the database to other manuscript maps later. This is the reason why it is possible to search for obvious subjects as Charles XII and the Great Northern War.

El castillo de Portilla (Zambrana, Álava: Origen y significado de una fortaleza plenomedieval en territorio alavés (siglos XI-XII

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Jose Luis Solaun Bustinza, Agustín Azkarate Garai-Olaun

2016-01-01

Las recientes investigaciones arqueológicas efectuadas en esta fortaleza han permitido conocer mejor su origen y significado. Las evidencias apuntan a que la actual fortaleza, construida entre principios del siglo XI y mediados del siglo XII, estuvo bajo titularidad real, aunque fue gestionada por importantes aristocracias locales y regionales, siendo testigo de las complejas relaciones entre el poder público y privado y, obviamente, de la multiplicidad de funciones que esta fortaleza pudo desempeñar.

En busca de una frontera entre Galicia y Portugal: Las tierras miñotas en los siglos XI-XII

OpenAIRE

Flórez Díaz, Javier

2017-01-01

RESUMEN: Con la realización de esta investigación trato de abordar cómo y cuándo se crea la frontera galaico-portuguesa. Y si es una creación ex novo y propia de la coyuntura peninsular; o bien refleja un pasado romano, suevo-visigodo y altomedieval hasta la propia formación de un nuevo Reino independiente: Portugal, en el siglo XII. Para ello, utilizaré fundamentalmente la documentación diocesana de la región (Orense, Tuy y Braga), la documentación de la cancillería regia portuguesa...

[Prediction of potential geographic distribution of Lyme disease in Qinghai province with Maximum Entropy model].

Science.gov (United States)

Zhang, Lin; Hou, Xuexia; Liu, Huixin; Liu, Wei; Wan, Kanglin; Hao, Qin

2016-01-01

To predict the potential geographic distribution of Lyme disease in Qinghai by using Maximum Entropy model (MaxEnt). The sero-diagnosis data of Lyme disease in 6 counties (Huzhu, Zeku, Tongde, Datong, Qilian and Xunhua) and the environmental and anthropogenic data including altitude, human footprint, normalized difference vegetation index (NDVI) and temperature in Qinghai province since 1990 were collected. By using the data of Huzhu Zeku and Tongde, the prediction of potential distribution of Lyme disease in Qinghai was conducted with MaxEnt. The prediction results were compared with the human sero-prevalence of Lyme disease in Datong, Qilian and Xunhua counties in Qinghai. Three hot spots of Lyme disease were predicted in Qinghai, which were all in the east forest areas. Furthermore, the NDVI showed the most important role in the model prediction, followed by human footprint. Datong, Qilian and Xunhua counties were all in eastern Qinghai. Xunhua was in hot spot areaⅡ, Datong was close to the north of hot spot area Ⅲ, while Qilian with lowest sero-prevalence of Lyme disease was not in the hot spot areas. The data were well modeled in MaxEnt (Area Under Curve=0.980). The actual distribution of Lyme disease in Qinghai was in consistent with the results of the model prediction. MaxEnt could be used in predicting the potential distribution patterns of Lyme disease. The distribution of vegetation and the range and intensity of human activity might be related with Lyme disease distribution.

The Effect of Industrial Work Performance Practice and Performance Automotive Electrical Prakti entrepreneurial n Against Interests Automotive Mechanics Class XII Smk Diponegoro Depok Sleman

OpenAIRE

Arif Mustofa; Pairun Roniwijaya

2013-01-01

The purpose of this study was to determine (1) the influence of the industrial working practices achievement entrepreneurial interests, (2) the effect of automotive electrical practice achievement against entrepreneurial interests, and (3) influence of achievement and accomplishment industry work practices automotive electrical practices to entrepreneurial interest Automotive Mechanics XII class students of SMK Diponegoro Depok Sleman school year 2012/2013.  The results showed that the test r...

Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy.

Science.gov (United States)

Hicks, Debbie; Farsani, Golara Torabi; Laval, Steven; Collins, James; Sarkozy, Anna; Martoni, Elena; Shah, Ashoke; Zou, Yaqun; Koch, Manuel; Bönnemann, Carsten G; Roberts, Mark; Lochmüller, Hanns; Bushby, Kate; Straub, Volker

2014-05-01

Bethlem myopathy (BM) [MIM 158810] is a slowly progressive muscle disease characterized by contractures and proximal weakness, which can be caused by mutations in one of the collagen VI genes (COL6A1, COL6A2 and COL6A3). However, there may be additional causal genes to identify as in ∼50% of BM cases no mutations in the COL6 genes are identified. In a cohort of -24 patients with a BM-like phenotype, we first sequenced 12 candidate genes based on their function, including genes for known binding partners of collagen VI, and those enzymes involved in its correct post-translational modification, assembly and secretion. Proceeding to whole-exome sequencing (WES), we identified mutations in the COL12A1 gene, a member of the FACIT collagens (fibril-associated collagens with interrupted triple helices) in five individuals from two families. Both families showed dominant inheritance with a clinical phenotype resembling classical BM. Family 1 had a single-base substitution that led to the replacement of one glycine residue in the triple-helical domain, breaking the Gly-X-Y repeating pattern, and Family 2 had a missense mutation, which created a mutant protein with an unpaired cysteine residue. Abnormality at the protein level was confirmed in both families by the intracellular retention of collagen XII in patient dermal fibroblasts. The mutation in Family 2 leads to the up-regulation of genes associated with the unfolded protein response (UPR) pathway and swollen, dysmorphic rough-ER. We conclude that the spectrum of causative genes in extracellular matrix (ECM)-related myopathies be extended to include COL12A1.

Pesca y trabajo en el reino de Toledo. La cuenca alta y media del Tajo en los siglos XII al XVI

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Sánchez Quiñones, Julián

2006-06-01

Full Text Available

This work treats about the professions related with the fishing in the Kingdom of Toledo, in the high and middle course of river Tagus, from XII-XVIth centuries. Along these pages we have seen many different kind of people, public servants, great merchants, workers of the fisheries, involved in the fishing, trading and delivering of fish in this time. So with this article, we break with the idea which identified the fishing only with fishing men and boats showing how the medieval society was interested in every economic activity which produced profits.

Le carte del monastero di S. Maria di Chiaravalle milanese. Additiones documentarie (secolo XII

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Maria Cristina Piva

2013-01-01

Full Text Available Founded in 1135 in the immediate outskirts of Milan, Cistercian monastery of S. Maria di Chiaravalle was one of the most important ecclesiastical institutions in Lombardy. Since its foundation, it has played a prominent role in the political, religious, social and economic life of the city. In the Middle Ages the abbey distinguished itself with intensive production and preservation of documents, exemplified nowadays by the several hundreds of charterse preserved in the Archivio di Stato of Milan. This research aims to complete the organic reconstruction work, recently carried out by Anna Maria Rapetti and Ada Grossi regarding the XII century tabularium of Chiaravalle, with the critical edition of 28 unreleased documents dated between 1106 and 1164. In the introduction, in addition to the presentation of the documents, a paragraph will outline the historiographical balance of the studies conducted so far on the abbey.

Diseases and pests in biomass production systems

International Nuclear Information System (INIS)

Royle, D.J.; Hunter, Tom; McNabb, H.S. Jr.

1998-01-01

The current status of disease and pest problems in willow and poplar biomass systems for energy within Canada, Sweden, the United Kingdom and the United States is described. The IEA Disease and Pest Activities within the recent Task XII (1995-1997), and previous Tasks since 1987, have provided outstanding opportunities for international co-operation which has served substantially to augment national research programmes. Work is described on recognizing different forms of an insect pest or pathogen and understanding the genetic basis of its variability, which is of fundamental importance in developing pest management strategies that exclude inputs of energy-rich materials such as pesticides. Options for more natural pest control are considered including breeding for resistance, plantation designs based on host genotype diversity and biological control 16 refs, 2 figs

Hubungan Kematangan Emosi dengan Pengambilan Keputusan Karir pada Siswa Kelas XII SMA

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Yashinta Rizky Ananda

2017-08-01

Full Text Available This research is done because the phenomenon in Senior High School 1 Mijen-Demak. Based on the record of events, it’s found that students of XII class have not seen the emotional maturity and the decision making of career after graduation. The purpose of this research is to find out relation of the emotional maturity and the career decision making. This research is an ex post facto with the quantitative correlation method. The samples used in this research are 114 students. The data collection that is used the emotional maturity and career decision making scale. The data analysis that is used the descriptive percentage and product moment correlation. The research result shows that 99 of students have the high emotional maturity, 98 of the students have the high decision making of career skill, and the sig is 0,000=0%, less than α=5% with r=0,348. There is a significant relation between the emotional maturity and the decision making of career in the low level of relationship. So, it can be said that the Ho is rejected and the Ha is accepted.

SOME CHURCH MANAGEMENT IN THE PRINCIPALITY SOUTHEAST RUSSIA IN XI-XII CENTURIES

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Наталья Вячеславовна Логачёва

2014-12-01

Full Text Available This paper shows that the joint cooperation of church and state in the principalities of South-Eastern XI-XII centuries. Emphasizes that the problem is not only scientific but also of practical interest for the modern Russian society. This experience is for national history an invaluable contribution to the field, both secular and ecclesiastical administration in feudal principalities and Old Russian state as a whole. Particular attention is paid to the analysis of the process of establishing the relationship between church and state, which were formed, changed and improved over the centuries. In particular, the article says that the medieval relations between church and state were more active and expressed that the church served a number of public functions and is thus, a special part of government agencies and their authorities. At the same time, the author notes that the church was in this historical financial content of the state apparatus. In view of this church-state relations in ancient Russia, primarily in the South-East of Russia, wore a special character - the church was interested in the state, and the state - in the church.

CORRELATION OF INTEREST TO LEARN AND USE TIME LEARNING WITH LEARNING ACHIEVEMENT AUTOMOTIVE ELECTRICAL IN CLASS XII LIGHT VEHICLE ENGINEERING SMK PIRI I YOGYAKARTA ACADEMIC YEAR 2013/2014

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Ari Pujiatmoko

2014-06-01

Full Text Available The purpose of this study were: 1 to determine whether there is a correlation between students' interest in learning and the learning achievement of automotive electrical, 2 to determine whether there is a correlation between the use of time studying the learning achievement of automotive electrical, 3 to determine whether there is a correlation between student interest and use the time to learn and the learning achievement of students of class XII automotive electrical TKR SMK PIRI 1 Yogyakarta academic year 2013/2014.  This research was conducted in class XII TKR SMK PIRI 1 Yogyakarta academic year 2013/2014. This study is an ex-post facto. This study used two independent variables and the interest in learning the use of learning time, while the dependent variable is the electrical automotive learning achievement. This study is a population study by the respondent amounted to 100 students. Techniques of data collection using questionnaire techniques and engineering documentation. Research instrument in this study is a questionnaire interest in learning, inquiry learning time management and documentation of student achievement. Trials using the instrument validity and reliability test. The analysis technique used is the prerequisite test for normality, linearity, and multicollinearity. Then test hypotheses using partial correlation analysis techniques and correlation.  The results showed that: 1 students' interest to have a strong positive correlation with school performance automotive electrical ρ value of 0.737; 2 the use of learning time have a low positive correlation with school performance automotive electrical ρ value of 0.275; 3 interest student learning and the use of study time has a very strong positive correlation with learning achievement of students of class XII automotive electrical TKR SMK PIRI I Yogyakarta academic year 2013/2014 as evidenced by the value of R = 0.811.

Energy Levels and Radiative Rates for Transitions in F-like Sc XIII and Ne-like Sc XII and Y XXX

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Kanti M. Aggarwal

2018-05-01

Full Text Available Energy levels, radiative rates and lifetimes are reported for F-like Sc XIII and Ne-like Sc XII and Y XXX for which the general-purpose relativistic atomic structure package (GRASP has been adopted. For all three ions, limited data exist in the literature but comparisons have been made wherever possible to assess the accuracy of the calculations. In the present work, the lowest 102, 125 and 139 levels have been considered for the respective ions. Additionally, calculations have also been performed with the flexible atomic code (FAC to (particularly confirm the accuracy of energy levels.

Energy Levels and Radiative Rates for Transitions in F-like Sc XIII and Ne-like Sc XII and Y XXX

Science.gov (United States)

Aggarwal, Kanti

2018-05-01

Energy levels, radiative rates and lifetimes are reported for F-like Sc~XIII and Ne-like Sc~XII and Y~XXX for which the general-purpose relativistic atomic structure package ({\\sc grasp}) has been adopted. For all three ions limited data exist in the literature but comparisons have been made wherever possible to assess the accuracy of the calculations. In the present work the lowest 102, 125 and 139 levels have been considered for the respective ions. Additionally, calculations have also been performed with the flexible atomic code ({\\sc fac}) to (particularly) confirm the accuracy of energy levels.

Spatial distribution of 12 class B notifiable infectious diseases in China: A retrospective study.

Science.gov (United States)

Zhu, Bin; Fu, Yang; Liu, Jinlin; Mao, Ying

2018-01-01

China is the largest developing country with a relatively developed public health system. To further prevent and eliminate the spread of infectious diseases, China has listed 39 notifiable infectious diseases characterized by wide prevalence or great harm, and classified them into classes A, B, and C, with severity decreasing across classes. Class A diseases have been almost eradicated in China, thus making class B diseases a priority in infectious disease prevention and control. In this retrospective study, we analyze the spatial distribution patterns of 12 class B notifiable infectious diseases that remain active all over China. Global and local Moran's I and corresponding graphic tools are adopted to explore and visualize the global and local spatial distribution of the incidence of the selected epidemics, respectively. Inter-correlations of clustering patterns of each pair of diseases and a cumulative summary of the high/low cluster frequency of the provincial units are also provided by means of figures and maps. Of the 12 most commonly notifiable class B infectious diseases, viral hepatitis and tuberculosis show high incidence rates and account for more than half of the reported cases. Almost all the diseases, except pertussis, exhibit positive spatial autocorrelation at the provincial level. All diseases feature varying spatial concentrations. Nevertheless, associations exist between spatial distribution patterns, with some provincial units displaying the same type of cluster features for two or more infectious diseases. Overall, high-low (unit with high incidence surrounded by units with high incidence, the same below) and high-high spatial cluster areas tend to be prevalent in the provincial units located in western and southwest China, whereas low-low and low-high spatial cluster areas abound in provincial units in north and east China. Despite the various distribution patterns of 12 class B notifiable infectious diseases, certain similarities between

Medicinal Flowers. XXXII. Structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis.

Science.gov (United States)

Morikawa, Toshio; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Ninomiya, Kiyofumi; Matsuda, Hisashi; Hamao, Makoto; Muraoka, Osamu; Hayakawa, Takao; Yoshikawa, Masayuki

2011-01-01

Five new triterpene saponins perennisosides VIII (1), IX (2), X (3), XI (4), and XII (5) were isolated from the MeOH-eluated fraction of the methanolic extract from the flowers of Bellis perennis. The MeOH-eluted fraction of the methanolic extract from the flowers of B. perennis was found to inhibit gastric emptying in olive oil-loaded mice at a dose of 200 mg/kg, per os (p.o.). The stereostructures of 1-5 were elucidated on the basis of chemical and spectroscopic evidence.

Comparison of CSF Distribution between Idiopathic Normal Pressure Hydrocephalus and Alzheimer Disease.

Science.gov (United States)

Yamada, S; Ishikawa, M; Yamamoto, K

2016-07-01

CSF volumes in the basal cistern and Sylvian fissure are increased in both idiopathic normal pressure hydrocephalus and Alzheimer disease, though the differences in these volumes in idiopathic normal pressure hydrocephalus and Alzheimer disease have not been well-described. Using CSF segmentation and volume quantification, we compared the distribution of CSF in idiopathic normal pressure hydrocephalus and Alzheimer disease. CSF volumes were extracted from T2-weighted 3D spin-echo sequences on 3T MR imaging and quantified semi-automatically. We compared the volumes and ratios of the ventricles and subarachnoid spaces after classification in 30 patients diagnosed with idiopathic normal pressure hydrocephalus, 10 with concurrent idiopathic normal pressure hydrocephalus and Alzheimer disease, 18 with Alzheimer disease, and 26 control subjects 60 years of age or older. Brain to ventricle ratios at the anterior and posterior commissure levels and 3D volumetric convexity cistern to ventricle ratios were useful indices for the differential diagnosis of idiopathic normal pressure hydrocephalus or idiopathic normal pressure hydrocephalus with Alzheimer disease from Alzheimer disease, similar to the z-Evans index and callosal angle. The most distinctive characteristics of the CSF distribution in idiopathic normal pressure hydrocephalus were small convexity subarachnoid spaces and the large volume of the basal cistern and Sylvian fissure. The distribution of the subarachnoid spaces in the idiopathic normal pressure hydrocephalus with Alzheimer disease group was the most deformed among these 3 groups, though the mean ventricular volume of the idiopathic normal pressure hydrocephalus with Alzheimer disease group was intermediate between that of the idiopathic normal pressure hydrocephalus and Alzheimer disease groups. The z-axial expansion of the lateral ventricle and compression of the brain just above the ventricle were the common findings in the parameters for differentiating

The constructive process in the Cimorro zone in the the Cathedral of Avila, (century XII-XIV. Hypothesis and its verification through the analysis of Structural Stability Smart and Sustainable Offices (SSO

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Mª A. Benito Pradillo

2018-01-01

Full Text Available This paper presents a hypothesis about the order in the constructive process for the head zone in the Cathedral of Ávila, called Cimorro. The hypothesis proposed in this area considers for its construction three different stages: XII Century, XIII Century and XIV Century. The proposed hypotesis have been verified with the Analysis of Stability realised. The theoretical Framework used is the Limit Analysis to Masonry Structures. After prooving the Structural Stability for each of the building stages, the following conclusions are made: Through the XII Century, the possibility of closing the central vault without Buttress System for a short period of time and the subsequent placement of a tribune is stated. A fortification formed by the barbican and the «adarves» were built during the XIII Century. In the XIV Century, the tribune is removed and replaced with the Buttress System with buttress and double flying buttress, which we can see nowadays.

Voyages of a successful text. The Dialogi of Gregory the Great in Medieval Sicily (XII-XIV Century

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Rossana Barcellona

2013-10-01

Full Text Available This essay reconstructs two “Sicilian chapters” of great success from the Dialogi by Gregorius Magnus which were enjoyed in the medieval era. These are the legend of Placido (Placido is a Benedict's young disciple mentioned in the Dialogi, which has Sicily as a background, as recounted by Pietro, Deacon of Montecassino between the XI and the XII centuries, and the Sicilian vulgarization of the work, carried out by Giovanni Campolo in the first half of the XIV century. The literary voyage of Placido and the work of Campolo are two excellent examples of the circulation and the fruition of an exemplary and authoritative text. Each highlights the complex intricacy of religion, culture and politics in the various systems of power and in the various historical settings that the medieval age explored.

Pengaruh Komunikasi, Kepemimpinan dan Motivasi Kerja Terhadap Kinerja Karyawan Studi Pada Kantor Wilayah XII Direktorat Jenderal Kekayaan Negara (DJKN Banjarmasin

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Andi Susanto

2016-04-01

Full Text Available This research aims to fi nd out and analyze the infl uence among communication (X1, leadership (X2, and work motivation (X3 as indefendent variables either partially or simultaneously toward employee’s performance (Y as dependent variable at Kantor Wilayah XII DJKN Banjarmasin. The method of this research used questionnaire with 32 employees of Kantor Wilayah  XII  DJKN  Banjarmasin  as  a  sample  and  it  has  been  selected  from population  as  45  emplyees.  The  variables  measurement  uses  Likert’s  Scale technique with weighting scale from 1 to 5. To fi nd out the correlation among variables X1 X2 X3 towards Y uses statistical technique of correlation analysis,  multiple linear regression and to test the signifi cance rate uses F test and t test processed with SPSS Program. The  result  of  research  concludes  that  there  is  a  positive  signifi cant  infl uence from each indefendent variable’s toward the dependent variable. From the three indefendent  variables,  the  highest  percentage  (25.9%  is  the  communication (X1  as  compared  with  the  two  other  independent  variables.  And  there  is  a signifi cant  simultaneously  infl uence  from  the  three  independent  variables toward the variable of employee’s performance. Keyword :Communication, leadership, work motivation, performance.

Gambaran Strategi Coping Stress Siswa Kelas XII Sman 42 Jakarta dalam Menghadapi Ujian Nasional

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Muhamad Nanang Suprayogi

2011-04-01

Full Text Available This study intended to know the description of stress coping strategies of 12th grade students of Jakarta 42 State Senior High School in facing National Exam. This study stems from the interest of researchers towards the number of cases of high school students who do not pass the National Exam. Researchers seek to impart knowledge to students on how to cope with their stress effectively and to the school and parents for providing the proper approach for students to face the National Exam. This study is a quantitative study using questionnaires as a measurement to know the description of stress coping strategies of Jakarta 42 State Senior High School students. Research instruments are compiled based on the theory developed by Lahey. In this research, obtained results that the class XII students of SMAN 42 Jakarta have a more predominant use of effective coping to cope with their stress in facing the National Exam. The most widely used strategy is removing stress and managing stress reaction  

Prevalence and Distribution of Neurological Disease in a Neurology ...

African Journals Online (AJOL)

Uche

Annals of Medical and Health Sciences Research – January 2011 – Vol. 1 N0.1. >>>63<<<. Prevalence and Distribution of Neurological Disease in a. Neurology Clinic in Enugu, Nigeria. Onwuekwe IO* and Ezeala-Adikaibe B*. *Neurology Unit, Department of Medicine,. University of Nigeria Teaching Hospital, Enugu, ...

How Do R&D Programs Funded by the Dg Xii (Science, Research and Development Directorate of the European Commission Impact the Upstream Oil and Gas Industry in Europe? Comment les programmes de R&D financés par la DG XII de la Commission européenne influencent-ils l'industrie pétrolière amont en Europe ?

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Forbes P.

2006-12-01

Full Text Available This paper provides an overview of the direct and indirect impact which DG XII funding for research and development has on the oil and gas exploration and production industry in Europe. Despite the relatively low level of funding, the impact is quite significant. These impacts are presented using a bottom-up analysis, starting with the impact of technology on industry and society, the impact of research on technology, and the impact of DG XII funding on both research and technology for the exploration and production of oil and gas. The different aspects that are discussed include the direct impact, the impact on R&D organization and management, and the impact due to the Commission demonstration program for oil and gas (Thermie. Examples are provided from current and past project results. The future impact on the industry, and Commission policy toward the oil and gas sector are suggestedIn the near future, it is expected that there will be greater impact on production technologies, on the contribution of oil and gas companies to long-term R&D, and on the transfer of results to the Commission demonstration program. L'article apporte une vue d'ensemble sur la manière dont les financements de la DG XII pour la recherche et le développement (R&D ont une influence, directe ou indirecte, sur l'exploration et la production dans l'industrie du pétrole et du gaz en Europe. Le niveau de ces financements est présenté comme relativement faible de façon à mettre en évidence que, comparativement, leur répercution est très significative. L'impact de ces financements est abordé en couvrant successivement les effets sur la société, l'industrie, la technologie et finalement la recherche elle-même. Nous décrivons ici les influences de la technologie sur l'industrie et sur la société, puis les influences de la recherche sur la technologie et enfin celles des financements de la DG XII sur la recherche et la technologie en exploration-production. Diff

PENGARUH PRAKTIK KERJA INDUSTRI DAN LINGKUNGAN KELUARGA TERHADAP MOTIVASI BERWIRAUSAHA SISWA KELAS XII PEMASARAN SMK NEGERI 2 SEMARANG

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Sodikin

2014-06-01

Full Text Available Motivasi siswa untuk menjadi seorang wirausaha dipengaruhi oleh praktik kerja industri dan lingkungan keluarga. Permasalahan penelitian ini adalah: sebesar besar pengaruh praktik kerja industri dan lingkungan keluarga terhadap motivasi berwirausaha siswa baik secara parsial maupun simultan. Populasi dalam penelitian ini berjumlah 99 siswa yang terdiri dari kelas XII Pemasaran SMK Negeri 2 Semarang, karena merupakan penelitian populasi sehingga semua populasi dijadikan sampel penelitian. Variabel yang diteliti yaitu variabel praktik kerja industri, lingkungan keluarga dan motivasi berwirausaha. Metode pengumpulan data menggunakan angket dan dokumentasi. Analisis data menggunakan analisis deskripsi persentase dan analisis regresi berganda. Hasil penelitian uji regresi menunjukkan hasil uji parsial untuk praktik kerja industri diperoleh thitung sebesar 4,847 dengan signifikansi 0,000 dan lingkungan keluarga diperoleh thitung sebesar 3,182 dengan signifikansi 0,002 berarti H0 ditolak dan Ha1, Ha2, Ha3 diterima. Besarnya pengaruh secara parsial untuk variabel praktik kerja industri sebesar 19,62% dan lingkungan keluarga sebesar 9,55%, secara simultan sebesar 44%. Student motivation to become an entrepreneur is influenced by industry work practices and family environment. The problems of this research are: the influence of industry work practices and family environment against entrepreneurial motivation either partially or simultaneously. The population in this study is composed of 99 students of class XII SMK N 2 Semarang Marketing, as a research population so that all the population made research sample. The variables studied were industry work practices, family environment and entrepreneurial motivation. Methods of data collection using questionnaire and documentation. Data analysis using descriptive analysis and multiple regression analysis percentage. Results of regression studies showed partial test results obtained for industrial work practices

PENGARUH STRATEGI PEMBELAJARAN PRAKTIKUM SIFAT KOLIGATIF TERHADAP HASIL BELAJAR SISWA KELAS XII

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Muhammad Hubbi

2017-01-01

belajar siswa kelas XII IPA Madrasah Aliyah Ma’arif 7 Lamongan pada materi sifat koligatif larutan. Hasil belajar berupa nilai yang berasal laporan hasil praktikum dan tes tulis. Subyek penelitian ini adalah 34 siswa kelas XII-E IPA Madrasah Aliyah Ma’arif 7 Lamongan tahun pelajaran 2015-2016. Rancangan penelitian yang digunakan adalah the one group pretest-posttest. Instrumen penelitian menggunakan tes tulis dan lembar observasi. Tes tulis untuk mengukur hasil belajar divalidasi sebelum digunakan dan memiliki reliabilitas 0,802. Data yang diperoleh selanjutnya dianalisis dengan analisis deskriptif dan uji beda. Uji beda menggunakan uji t-paired. Hasil uji-t berpasangan diperoleh sig 0,000 yang berarti lebih kecil dari 0,05 sehingga H0 ditolak dengan reliabilitas 95%. Berdasarkan hasil tersebut dapat disimpulkan bahwa terdapat peningkatan hasil belajar yang signifikan pada pembelajaran praktikum dengan menggunakan prosedur praktikum sifat koligatif larutan. Nilai rata-rata hasil belajar siswa meningkat dari 61,05 menjadi 81,44. Peningkatan ini menunjukkan pembelajaran praktikum berbasis inkuiri terbimbing memiliki tingkat efektivitas yang baik.

Disease clusters, exact distributions of maxima, and P-values.

Science.gov (United States)

Grimson, R C

1993-10-01

This paper presents combinatorial (exact) methods that are useful in the analysis of disease cluster data obtained from small environments, such as buildings and neighbourhoods. Maxwell-Boltzmann and Fermi-Dirac occupancy models are compared in terms of appropriateness of representation of disease incidence patterns (space and/or time) in these environments. The methods are illustrated by a statistical analysis of the incidence pattern of bone fractures in a setting wherein fracture clustering was alleged to be occurring. One of the methodological results derived in this paper is the exact distribution of the maximum cell frequency in occupancy models.

Estrategias de subsistencia en los momentos finales del Pleistoceno medio: el nivel XII de la Cova del Bolomor (La Valldigna, Valencia

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Ruth BLASCO

2009-08-01

Full Text Available RESUMEN: La Cova del Bolomor, situada en Tavernes de la Valldigna (Valencia, ofrece uno de los mejores registros faunísticos de la segunda mitad del Pleistoceno medio de la Península Ibérica. La cavidad contiene un relleno sedimentario formado por diecisiete niveles estratigráficos que abarcan desde el OIS 9 al OIS 5e. Esta amplia secuencia cronológica permite abordar diferentes cuestiones relacionadas con los grupos humanos de este periodo y sus relaciones con el medio ambiente. Concretamente, a partir del estudio zooarqueológico del nivel XII (OIS 6, se ha reconstruido la secuencia antrópica de obtención y procesamiento de los recursos faunísticos. De este modo, se han identificado diferentes estrategias de subsistencia llevadas a cabo por los homínidos para la obtención de los animales. Estas técnicas van desde el carroñeo hasta la caza e incluyen el aprovisionamiento de pequeñas presas como las aves (Cygnus olor o los lepóridos (Oryctolagus cuniculus. Esta variabilidad de estrategias podría interpretarse como la gran capacidad de adaptación que poseen estos grupos humanos para aprovechar las oportunidades que el medio les ofrece. También se ha observado la existencia de patrones bien sistematizados tanto en el aprovechamiento de los recursos faunísticos externos (piel, carne, tendones como en la obtención de los recursos internos (médula. Muchos de los elementos diagnósticos que evidencian la fracturación antrópica en el nivel XII presentan cierta sistematización en zonas y partes anatómicas concretas. La existencia de morfologías repetidas en algunos elementos esqueléticos indica una cierta estandarización a la hora de fracturar los huesos. Esta reiteración podría implicar la existencia de mecanismos de aprendizaje o de transmisión de información intergrupal por parte de los grupos humanos del Pleistoceno medio final. En general, este estudio pretende aportar datos sobre las estrategias de subsistencia de

“The Testament” of XII Pandito Hambo-Lama Dashidorzhi Ithegelov in the Context of Buddhist Philosophy

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Elizaveta E. Baldanmaksarova

2017-12-01

Full Text Available The article deals with a hitherto unexamined literary text written by a famous Buddhist philosopher and scientist XII Pandito Hambo-Lama Dashidorzhi Itigelov. This text is the last poem by D. Itigelov entitled “The Testament” (1927 written in the genre of the epistle and addressed to the people of the 21 st century. 2017 is a year of the 90th anniversary of the phenomenal state achieved by the philosopher; on September 10, Buryat people celebrate the 15th anniversary of his acquisition of the Precious Inexhaustible Body. Not only was D. Itigelov a leader of the Buryat society who headed its religious and secular (state activity until 1917, he also was an educated theologian and a gifted writer who left rich literary, religious, and philosophical heritage relevant in the context of the Buddhist aesthetics and philosophy. This essay calls for the necessity to make this heritage available to public by stressing its originality and relevance for contemporary society.

Preliminary Investigations of The Bioarchaeology of Medieval Giecz (XI-XII C.: Examples of Trauma and Stress

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Agnew Amanda M.

2014-07-01

Full Text Available Human skeletal remains from past populations are an invaluable source to objectively study biological history. The combined biological and cultural assessment of bioarchaeology offers a unique perspective on the adaptation of people to their environment. This study summarizes a portion of ongoing work to decipher trends related to health and lifestyle in early medieval (XI-XII c. Giecz, Poland. The skeletal assemblage from Giecz, the “Giecz Collection”, represents a community positioned at a major center of political, economic, and religious power during this important time in Polish history. Non-violent traumatic injuries were investigated to elucidate trends related to possible types and rigor of activities and linear femoral growth trends were analyzed to assess patterns of stress. Preliminary results suggest that all members of the community (men, women, and adolescents contributed to a lifestyle characterized by repetitive hard-work. Furthermore, it appears that most individuals suffered from health insults negatively affecting their development and perhaps their mortality.

La recepción del derecho justinianeo en España en la Baja Edad Media (siglos XII-XV). Un capítulo en la historia del derecho europeo

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Torrent Ruiz, Armando José

2013-01-01

La recepción del derecho justinianeo en España o, si se prefiere, la recepción del ius commune en España durante los s. XII-XV, es un capítulo más de los fundamentos del derecho europeo dentro de una historia del derecho que hoy ya no debe ser una historia de los derechos nacionales sino historia del derecho europeo

IMPLEMENTASI MODEL PEMBELAJARAN MIND MAP (PETA PIKIRAN) UNTUK MENINGKATKAN PRESTASI BELAJAR SISWA KELAS XII PADA MATA PELAJARAN RIAS WAJAH KHUSUS PROGRAM KEAHLIAN KECANTIKAN DI SMK NEGERI 27 JAKARTA PUSAT

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ARINDIKA, RUSY

2017-01-01

ABSTRACT   Rusy Arindika 2012. Implementation Of The Mind Map Learning For Improving Student Achievement Against Class XII On the Subject Special Makeup Courses Beauty Expertise at SMKN 27 Jakarta. Thesis. Jakarta : Makeup Course, Department of Family Welfare, Faculty of Engineering, State University of Jakarta. The research was conducted based on action research or action research, which consisted of two cycles, where the description on each cycle include: planning action, impl...

Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease

Science.gov (United States)

Serrano-Pozo, Alberto; Mielke, Matthew L.; Muzitansky, Alona; Gómez-Isla, Teresa; Growdon, John H.; Bacskai, Brian J.; Betensky, Rebecca A.; Frosch, Matthew P.; Hyman, Bradley T.

2012-01-01

Amyloid-β plaques are a key pathological feature of Alzheimer disease (AD), but whether plaque sizes increase or stabilize over the course of AD is unknown. We measured the size distribution of total immunoreactive (10D5-positive) and dense-core (Thioflavine-S-positive) plaques in the temporal neocortex of a large group of AD and plaque-bearing age-matched non-demented subjects to test the hypothesis that amyloid plaques continue to grow along with the progression of the disease. The size of amyloid-β (10D5)-positive plaques did not differ between groups whereas dense-core plaques from the AD group were slightly larger than those in the non-demented group (~25%–30%, p = 0.01). Within the AD group, dense-core plaque size did not independently correlate with duration of clinical disease (from 4 to 21 years, p = 0.68), whereas 10D5-positive plaque size correlated negatively with disease duration (p = 0.01). By contrast, an earlier age of symptom onset strongly predicted a larger postmortem plaque size; this effect was independent of disease duration and the presence of the APOEε4 allele (p = 0.0001). We conclude that plaques vary in size among patients, with larger size distributions correlating with an earlier age of onset, but plaques do not substantially increase in size over the clinical course of the disease. PMID:22805771

Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system.

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Shannon L Taylor

Full Text Available Hemorrhagic fever with renal syndrome (HFRS and hantavirus pulmonary syndrome (HPS are diseases caused by hantavirus infections and are characterized by vascular leakage due to alterations of the endothelial barrier. Hantavirus-infected endothelial cells (EC display no overt cytopathology; consequently, pathogenesis models have focused either on the influx of immune cells and release of cytokines or on increased degradation of the adherens junction protein, vascular endothelial (VE-cadherin, due to hantavirus-mediated hypersensitization of EC to vascular endothelial growth factor (VEGF. To examine endothelial leakage in a relevant in vitro system, we co-cultured endothelial and vascular smooth muscle cells (vSMC to generate capillary blood vessel-like structures. In contrast to results obtained in monolayers of cultured EC, we found that despite viral replication in both cell types as well as the presence of VEGF, infected in vitro vessels neither lost integrity nor displayed evidence of VE-cadherin degradation. Here, we present evidence for a novel mechanism of hantavirus-induced vascular leakage involving activation of the plasma kallikrein-kinin system (KKS. We show that incubation of factor XII (FXII, prekallikrein (PK, and high molecular weight kininogen (HK plasma proteins with hantavirus-infected EC results in increased cleavage of HK, higher enzymatic activities of FXIIa/kallikrein (KAL and increased liberation of bradykinin (BK. Measuring cell permeability in real-time using electric cell-substrate impedance sensing (ECIS, we identified dramatic increases in endothelial cell permeability after KKS activation and liberation of BK. Furthermore, the alterations in permeability could be prevented using inhibitors that directly block BK binding, the activity of FXIIa, or the activity of KAL. Lastly, FXII binding and autoactivation is increased on the surface of hantavirus-infected EC. These data are the first to demonstrate KKS activation

Sprawozdanie z XII Międzynarodowej Konferencji pt. „Edukacja a nowe technologie w kulturze, informacji i komunikacji” (Toruń, 09–10.06.2015)

OpenAIRE

Kwiatkowska, Wioletta

2016-01-01

W dniach 9−10 czerwca 2015 roku odbyła się XII Międzynarodowa Konferencja Naukowa z cyklu „Technologia informacyjna w zmieniającej się edukacji”. Temat przewodni konferencji brzmiał: „Edukacja a nowe technologie w kulturze, informacji i komunikacji”. W tej edycji konferencji poruszane były zagadnienia dotyczące nowych technologii i ich znaczenie dla edukacji. Inicjatywy o takim charakterze podejmowane od kilkunastu lat przez Katedrę Dydaktyki i Mediów w Edukacji wpisały się w tradycję Wydział...

‘Bois noir’: new phytoplasma disease of grapevine in Iran

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Mirchenari Seyed Mehdi

2015-01-01

Full Text Available Recently, grapevines showing symptoms suggesting the ‘bois noir’ phytoplasma disease were observed in vineyards located in several central provinces of Iran. Polymerase chain reaction assays using phytoplasma universal primer pair P1A/P7A followed by primer pair R16F2n/R16R2 in nested PCR, confirmed the association of phytoplasmas with symptomatic grapevines. The results of RFLP analyses using HpaII, HinfI, MseI, RsaI, and TaqI restriction enzymes, indicated that grapevine phytoplasma isolates in these regions could be related to the 16SrXII group. Sequence analyses of the partial 16S rRNA gene confirmed that Iranian grapevine phytoplasmas are associated with ‘Candidatus Phytoplasma solani’. This is the first report of the ‘bois noir’ disease outbreak in Iran

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Science.gov (United States)

Göbel, Kerstin; Pankratz, Susann; Asaridou, Chloi-Magdalini; Herrmann, Alexander M.; Bittner, Stefan; Merker, Monika; Ruck, Tobias; Glumm, Sarah; Langhauser, Friederike; Kraft, Peter; Krug, Thorsten F.; Breuer, Johanna; Herold, Martin; Gross, Catharina C.; Beckmann, Denise; Korb-Pap, Adelheid; Schuhmann, Michael K.; Kuerten, Stefanie; Mitroulis, Ioannis; Ruppert, Clemens; Nolte, Marc W.; Panousis, Con; Klotz, Luisa; Kehrel, Beate; Korn, Thomas; Langer, Harald F.; Pap, Thomas; Nieswandt, Bernhard; Wiendl, Heinz; Chavakis, Triantafyllos; Kleinschnitz, Christoph; Meuth, Sven G.

2016-01-01

Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify coagulation factor XII (FXII), the initiator of the intrinsic coagulation cascade and the kallikrein–kinin system, as a specific immune cell modulator. High levels of FXII activity are present in the plasma of MS patients during relapse. Deficiency or pharmacologic blockade of FXII renders mice less susceptible to experimental autoimmune encephalomyelitis (a model of MS) and is accompanied by reduced numbers of interleukin-17A-producing T cells. Immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner and involves alterations in intracellular cyclic AMP formation. Our study demonstrates that a member of the plasmatic coagulation cascade is a key mediator of autoimmunity. FXII inhibition may provide a strategy to combat MS and other immune-related disorders. PMID:27188843

AN ANALYSIS OF STUDENTS’ ABILITY IN USING SUB-ORDINATE CONJUNCTION IN SENTENCE WRITING OF THE GRADE XII STUDENTS OF SMA N 2 METRO ACADEMIC YEAR 2013/2014

OpenAIRE

Bambang Eko Siagianto

2017-01-01

Abstracts: Sub-ordinate conjunction is very confusing to comprehend by students. In using sub-ordinate conjunction, students usually had errors. The purpose of this research to analyze whether or not the students are able to use sub-ordinate conjunction in sentence writing, to classify kinds of sub-ordinate conjunction that was often misused by students in sentence writing The research was done at the grade XII of SMA N 2 Metro in second semester of the academic year 2013/2014. The predicted ...

A model for intra-familial distribution of an infectious disease (Chagas' disease

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M. F. Feitosa

1993-06-01

Full Text Available A probabilistic model for intra-familial distribution of infectous disease is proposed and applied to the prevalence of positive serology for Trypanosoma cruzi infection in Northeastern Brazilian sample. This double with one tail excess model fits satisfactorily to the data and its interpretation says that around 51% of these 982 families are free of infection risk; among those that are at risk, 3% have a high risk (0.66, probably due to high domestic infestation of the vector bug; while 97% show a small risk (0.11, probably due to accidental, non-domestic transmission.

ANALISIS NILAI – NILAI PENDIDIKAN KARAKTER PADA NOVEL SUTASOMA KARYA COK SAWITRI DAN RELEVANSINYA DENGAN PEMBELAJARAN BAHASA INDONESIA KELAS XII

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Sariasih Sariasih

2017-10-01

Full Text Available Tujuan penelitian ini adalah mendeskripsikan: (1 Nilai-nilai Penddikan Karakter Novel Sutasoma karya Cok Sawitri, (2 Struktur novel Sutasoma karya Cok Sawitri, dan (3 Relevansi nilai pendidikan karakter dalam Pembelajaran Bahasa Indonesia Kelas XII. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode deskriptif  kualitatif. Pengumpulan data menggunakan metode dokumentasi dengan media kartu data. Analisis data dengan menggunakan  model  analisis kualitatif yang  yang memiliki tiga tahap: (a reduksi data, (b penyajian data, (c penarikan kesimpulan dan verifikasi. Hasil penelitian menunjukkan hal berikut. Pertama, novel Sutasoma karya Cok Sawitri memuat nilai- nilai pendidikan karakter yaitu religius, jujur, toleransi, disiplin, kerja keras, kreatif, mandiri, demokratis, rasa ingin tahu, semangat kebangsaan, cinta tanah air, menghargai prestasi, bersahabat atau komunikatif, peduli lingkungan, peduli sosial. Kedua novel Sutasoma terdiri dari struktur dalam dan luar. Struktur dalam atau unsur intrinsik, yaitu tema, alur, latar, penokohan serta sudut pandang. Adapun simpulan penelitian ini yaitu : (1 Novel Sutasoma memuat 17 nilai-nilai pendidikan karakter, (2 Struktur novel sutasoma terdiri dari struktur dalam dan struktur luar, (3 Proses kreatif pengarang dalam menciptakan novel yang terinspirasi dari karya Empu Tantular dengan judul resmi Parusadha yang populer dengan nama Sutasoma. Dalam kisah novel Sutasoma karya Cok Sawitri ternyata ditemukan pula proses ajaran Mahayan Tantra, yang mengungkapkan jalan rahasia yoga tantra, dan bagaimana seorang raja menerapkan dharma agama, dharma negara tanpa mempehitungkan kebhinekaan. Alur pada novel Sutasoma karya Cok Sawitri  dengan nilai -nilai pendidi kan karakter yang terdapat di dalamnya dapat memberikan inspirasi bagi pembaca. Hal ini berarti ada nilai-nilai positif yang dapat diambil dan direalisasikan oleh pembaca dalam kehidupan sehari-hari. Nilai pendidikan karakter dalam

Specification of electron beam quality from ionization distribution in central axis and a study about heterogenity effects in these distributions

International Nuclear Information System (INIS)

Fernandes, R.F.

1984-01-01

Some parameters on physical and terapeutic properties of the electron beams generated by ''nevratron XII'' accelerator of the Hospital of Medicine in Ribeirao Preto - USP, Brasil are evaluated. The effects from heterogenities into an irradiated mean, called ''phantom'' or simulator are studied. (M.J.C.) [pt

Coronary Artery Calcium Distribution and Interscan Measurement Variability in End-Stage Renal and Coronary Heart Disease Patients

International Nuclear Information System (INIS)

Serafin, Z.; Laskowska, K.; Marzec, M.; Lasek, W.; Sinjab, T.A.; Wlodarczyk, Z.

2009-01-01

Background: Coronary heart disease patients and end-stage renal disease patients have been documented to have an increased amount of coronary artery calcifications (CAC). Purpose: To evaluate the distribution of CAC and its influence on interscan variability of measurement in end-stage renal disease and coronary heart disease patients, proven to have calcifications. Material and Methods: 69 patients having CAC, including 34 with coronary heart disease and 35 with end-stage renal disease, were scanned twice with multidetector-row computed tomography (MDCT). Amount of CAC was determined as the number of calcified lesions (CN), total calcium score (CS), calcium volume (CV), and calcium mass (CM). Distribution of CAC was evaluated on a per-patient basis as the median CS and CM of a single lesion. Density of the calcifications was calculated as the patient's CM divided by CV. Results: The overall median CS was 457.2, and the median CM was 75.6 mg. There were no significant differences in the number of calcified lesions, CS, or CM between the two groups. Both CS and CM of a single lesion, as well as the mean calcium density were lower in renal disease patients (P<0.05) than in coronary heart disease subjects. The relative interscan variability of coronary calcium measurement was higher in the renal disease group (P<0.05). There was a negative correlation between the calcium concentration and the relative interscan variability. Conclusion: The results indicate that the coronary calcium distribution influences the measurement interscan reproducibility, and the distribution may differ between end-stage renal disease patients and coronary heart disease patients, reflecting the dissimilar nature of coronary calcifications in those groups

Coronary Artery Calcium Distribution and Interscan Measurement Variability in End-Stage Renal and Coronary Heart Disease Patients

Energy Technology Data Exchange (ETDEWEB)

Serafin, Z.; Laskowska, K.; Marzec, M.; Lasek, W. (Dept. of Radiology and Diagnostic Imaging, Nicolaus Copernicus Univ., Collegium Medicum, Bydgoszcz (Poland)); Sinjab, T.A.; Wlodarczyk, Z. (Dept. of Transplantology, Nicolaus Copernicus Univ., Collegium Medicum, Bydgoszcz (Poland))

2009-04-15

Background: Coronary heart disease patients and end-stage renal disease patients have been documented to have an increased amount of coronary artery calcifications (CAC). Purpose: To evaluate the distribution of CAC and its influence on interscan variability of measurement in end-stage renal disease and coronary heart disease patients, proven to have calcifications. Material and Methods: 69 patients having CAC, including 34 with coronary heart disease and 35 with end-stage renal disease, were scanned twice with multidetector-row computed tomography (MDCT). Amount of CAC was determined as the number of calcified lesions (CN), total calcium score (CS), calcium volume (CV), and calcium mass (CM). Distribution of CAC was evaluated on a per-patient basis as the median CS and CM of a single lesion. Density of the calcifications was calculated as the patient's CM divided by CV. Results: The overall median CS was 457.2, and the median CM was 75.6 mg. There were no significant differences in the number of calcified lesions, CS, or CM between the two groups. Both CS and CM of a single lesion, as well as the mean calcium density were lower in renal disease patients (P<0.05) than in coronary heart disease subjects. The relative interscan variability of coronary calcium measurement was higher in the renal disease group (P<0.05). There was a negative correlation between the calcium concentration and the relative interscan variability. Conclusion: The results indicate that the coronary calcium distribution influences the measurement interscan reproducibility, and the distribution may differ between end-stage renal disease patients and coronary heart disease patients, reflecting the dissimilar nature of coronary calcifications in those groups.

[Spatial distribution of occupational disease prevalence in Guangzhou and Foshan city by geographic information system].

Science.gov (United States)

Tan, Q; Tu, H W; Gu, C H; Li, X D; Li, R Z; Wang, M; Chen, S G; Cheng, Y J; Liu, Y M

2017-11-20

Objective: To explore the occupational disease spatial distribution characteristics in Guangzhou and Foshan city in 2006-2013 with Geographic Information System and to provide evidence for making control strategy. Methods: The data on occupational disease diagnosis in Guangzhou and Foshan city from 2006 through 2013 were collected and linked to the digital map at administrative county level with Arc GIS12.0 software for spatial analysis. Results: The maps of occupational disease and Moran's spatial autocor-relation analysis showed that the spatial aggregation existed in Shunde and Nanhai region with Moran's index 1.727, -0.003. Local Moran's I spatial autocorrelation analysis pointed out the "positive high incidence re-gion" and the "negative high incidence region" during 2006~2013. Trend analysis showed that the diagnosis case increased slightly then declined from west to east, increase obviously from north to south, declined from? southwest to northeast, high in the middle and low on both sides in northwest-southeast direction. Conclusions: The occupational disease is obviously geographical distribution in Guangzhou and Foshan city. The corresponding prevention measures should be made according to the geographical distribution.

Latitude, sunshine, and human lactase phenotype distributions may contribute to geographic patterns of modern disease: the inflammatory bowel disease model

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Szilagyi A

2014-05-01

Full Text Available Andrew Szilagyi,1 Henry Leighton,2 Barry Burstein,3 Xiaoqing Xue41Division of Gastroenterology, Department of Medicine, Jewish General Hospital, 2Department of Atmospheric and Oceanic Sciences, 3Department of Medicine, Jewish General Hospital, 4Department of Emergency Medicine, Jewish General Hospital, McGill University, Montreal, QC, CanadaAbstract: Countries with high lactase nonpersistence (LNP or low lactase persistence (LP populations have lower rates of some “western” diseases, mimicking the effects of sunshine and latitude. Inflammatory bowel disease (IBD, ie, Crohn's disease and ulcerative colitis, is putatively also influenced by sunshine. Recent availability of worldwide IBD rates and lactase distributions allows more extensive comparisons. The aim of this study was to evaluate the extent to which modern day lactase distributions interact with latitude, sunshine exposure, and IBD rates. National IBD rates, national distributions of LP/LNP, and population-weighted average national annual ultraviolet B exposure were obtained, estimated, or calculated from the literature. Negative binomial analysis was used to assess the relationship between the three parameters and IBD rates. Analyses for 55 countries were grouped in three geographic domains, ie, global, Europe, and non-Europe. In Europe, both latitude and ultraviolet B exposure correlate well with LP/LNP and IBD. In non-Europe, latitude and ultraviolet B exposure correlate weakly with LP/LNP, but the latter retains a more robust correlation with IBD. In univariate analysis, latitude, ultraviolet B exposure, and LP/LNP all had significant relationships with IBD. Multivariate analysis showed that lactase distributions provided the best model of fit for IBD. The model of IBD reveals the evolutionary effects of the human lactase divide, and suggests that latitude, ultraviolet B exposure, and LP/LNP mimic each other because LP/LNP follows latitudinal directions toward the equator

ABO blood group distribution and ischaemic heart disease

International Nuclear Information System (INIS)

Lutfullah, A.; Bhatti, T.A.; Hanif, A.; Shaikh, S.H.

2011-01-01

To study the association of ABO blood groups with ischaemic heart disease (IHD) in our setting. Analytic comparative study. Department of Cardiology, Mayo hospital, Lahore over a period of two years from January 2008 to December 2009. The study group included 907 patients of IHD. The distribution of ABO blood groups in IHD patients was compared with the control group of 907 non-IHD individuals. Data was analyzed using SPSS 16. Chi-square test for significance was used. P-value less than 0.05 was taken as significant. In this study, the following pattern of ABO blood groups was observed in IHD patients and non-IHD patients respectively : Blood group A 251 (27.67%) and 248 (27.34%); Blood group B 329 (36.27%) and 358 (39.47%); Blood group O 235 (25.90%) and 240 (24.46%); Blood group AB 92 (10.14%) and 61 (6.72%), P-value = 0.06. There is no association of ABO blood groups and ischaemic heart disease. (author)

Modeling the spatial distribution of Chagas disease vectors using environmental variables and people´s knowledge.

Science.gov (United States)

Hernández, Jaime; Núñez, Ignacia; Bacigalupo, Antonella; Cattan, Pedro E

2013-05-31

Chagas disease is caused by the protozoan Trypanosoma cruzi, which is transmitted to mammal hosts by triatomine insect vectors. The goal of this study was to model the spatial distribution of triatomine species in an endemic area. Vector's locations were obtained with a rural householders' survey. This information was combined with environmental data obtained from remote sensors, land use maps and topographic SRTM data, using the machine learning algorithm Random Forests to model species distribution. We analysed the combination of variables on three scales: 10 km, 5 km and 2.5 km cell size grids. The best estimation, explaining 46.2% of the triatomines spatial distribution, was obtained for 5 km of spatial resolution. Presence probability distribution increases from central Chile towards the north, tending to cover the central-coastal region and avoiding areas of the Andes range. The methodology presented here was useful to model the distribution of triatomines in an endemic area; it is best explained using 5 km of spatial resolution, and their presence increases in the northern part of the study area. This study's methodology can be replicated in other countries with Chagas disease or other vectorial transmitted diseases, and be used to locate high risk areas and to optimize resource allocation, for prevention and control of vectorial diseases.

Positional effects on distribution of ventilation in chronic obstructive pulmonary disease

International Nuclear Information System (INIS)

Shim, C.; Chun, K.J.; Williams, M.H. Jr.; Blaufox, M.D.

1986-01-01

Ventilation is distributed predominantly to the dependent lung in normal persons in the decubitus position. We evaluated the distribution of ventilation in four patients with mild-to-moderate chronic obstructive pulmonary disease using 81mKr gas. Patients were tested in the sitting and right and left decubitus positions with and without the application of positive end expiratory pressure (PEEP). In contrast to findings in controls, ventilation was predominantly distributed to the nondependent lung in patients in the decubitus position. Mean ventilation in the right lung decreased from 51% of the total in the sitting position to 31% in the right decubitus position; it increased with the application of 10 cm PEEP. Reduced ventilation in the dependent lung most likely is caused by closure of the airways after a decrease in volume. Application of PEEP resulted in increased lung volume and preferential distribution of ventilation to the dependent lung

Laminar Distribution of the Pathological Changes in Sporadic and Variant Creutzfeldt-Jakob Disease

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R. A. Armstrong

2011-01-01

Full Text Available The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD and variant CJD (vCJD. First, in some cortical regions, the vacuolation (“spongiform change” was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the “diffuse” and “florid” prion protein (PrPsc deposits were more frequently distributed in the upper cortex in vCJD and the “synaptic” deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology within the brain.

Proceedings of VI International Symposium on Nuclear and Related Techniques. XII Workshop on Nuclear Physics. WONP-NURT 2009

International Nuclear Information System (INIS)

2009-02-01

This year the XII Workshop on Nuclear Physics (WONP) and the VI Symposium on Nuclear and Related Techniques (NURT) are organized jointly, by Instituto Superior de Tecnologias y Ciencias Aplicadas and Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear. Both events gather scientists from several countries with top research work on nuclear physics and its applications. WONP has been carried out since 1994 promoting an ever-exchanging exchange between professionals of various nuclear and applied physics fields, those related to environmental and health care. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM

FAKTOR-FAKTOR YANG MEMPENGARUHI KREATIVITAS BELAJAR SISWA KELAS XII PEMASARAN PADA PEMBELAJARAN PRODUKTIF PEMASARAN DI SMK NEGERI 1 PURBALINGGA

Directory of Open Access Journals (Sweden)

Widiyaningrum Widiyaningrum

2016-11-01

Full Text Available Kurikulum 2013 merupakan kurikulum yang bertujuan untuk meningkatkan keaktifan, kreativitas, inovasi dan produktivitas.SMK N 1 Purbalingga merupakan SMK yang sudah menerapkan Kurikulum 2013, akan tetapi kreativitas siswa kelas XII Pemasaran masih rendah. Siswa masih memiliki kreativitas yang rendah pada materi penataan produk dan promosi produk. Kreativitas dapat dipengaruhi oleh faktor-faktor yang mempengaruhi. Faktor yang mempengaruh kreativitas yaitu situasi yang mengadirkan ketidaklengkapan serta keterbukaan, situasi yang memungkinkan dan mendorong banyak pertanyaan, situasi yang mendorong dalam rangka menghasilkan sesuatu, situasi yang mendorong tanggung jawab dan kemandirian, situasi yang menekankan inisiatif diri, kedwibahasaan. perhatian dari orang tuastimulasi dari lingkungan sekolah, motivasi diri. Penelitian ini menggunakan pendekatan kuantitatif dengan jumlah responden 38 siswa. metode pengumpulan datamenggunakan angket, dan metode analisis data menggunakan analisis faktor untuk mengetahui faktor dominan yang mempengaruhi kreativitas. Hasil penelitian menunjukkan terdapat dua faktor dominan yang mempengaruhi kreativitas, yaitu keadaan saat pembelajaran dan rangsangan dari lingkungan. Sehingga dapat disimpulkan bahwa kreativitas belajar siswa dipengaruhi oleh keadaan saat pembelajaran dan rangsangan dari lingkungan. Curriculum 2013 is a curriculum that aims to enhance the activity, creativity, innovation and productivity. SMK N 1 Purbalingga is already implementing vocational curriculum in 2013, but the creativity of students of class XII Marketing is still low. Students still have the creativity that is low on product structuring materials and promotional products. Creativity can be affected by factors affecting. Factors that influence the creativity that is the situation that presents the incompleteness and openness, a situation that enables and encourages a lot of questions, the situation is encouraging in order to produce

Radiation-attenuated vaccine for lungworm disease

International Nuclear Information System (INIS)

Singh, C.M.

1977-01-01

The work done at the Indian Veternary Research Institute, Izatnagar, on the development of a vaccine for lungworm diseases is reported. Research work done includes: (1) studies on the epidemiology and the incidence of the lungworm infections, (ii) studies on the radiation-attenuated lungworm Dictyocaulus filaria vaccine, (iii) studies on other parasites using ionizing radiation, (iv) incidence of lungworm infection in sheep in Jammu and Kashmir State, (v) suitable dose of gamma radiation for attenuation, (vi) laboratory studies with radiation-attenuated D. filaria vaccine, (vii) serology of D. filaria infection, (viii) field trials with the radiation-attenuated vaccine, (ix) immune response of previously exposed lambs to vaccination, (x) comparative susceptibility of sheep and goats to infection with D. filaria, (xi) quantitative studies of D. filaria in lambs and (xii) production and supply of lungworm vaccine. (A.K.)

Influencia de la historia de España (del siglo XII al XIX en el periodismo especializado en ciencia

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Dr. Carlos Elías

2001-01-01

Full Text Available El periodismo especializado en ciencia y tecnología en España no ha alcanzado los niveles de los países anglosajones. Ello se pone de manifiesto no sólo por la relativa ausencia de suplementos destinados a ciencia en los periódicos generalistas sino, sobre todo, por la ausencia de portales de Internet en los que se divulgue la ciencia en español así como los logros en este campo de la comunidad hispana. Pero esta circunstancia no es casual: es el producto de una historia, la de la ciencia en España, que siempre ha tenido muchos detractores, entre ellos la iglesia. En este artículo se analiza cómo influyó la historia de España desde el siglo XII hasta principios del XIX en el actual periodismo especializado en ciencia.

Uma pequena igreja, um grande almofariz cultural: iconografia céltica religiosa em Kilpeck, Inglaterra, século XII

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Elisabete Leal

2015-10-01

Full Text Available Este artigo discorre sobre alguns aspectos iconográficos presentes nas mísulas da igreja de St. Mary e St. David de Kilpeck, Herefordshire, Inglaterra, construída no século XII. Destacamos a presença de elementos que denunciam um forte hibridismo cultural entre o cristianismo e antigos símbolos religiosos, considerados, no mesmo contexto da construção, como símbolos pagãos e profanos. Desta forma, pretendemos salientar a complexidade dos processos culturais durante a Idade Média, e os fenômenos de circularidade cultural que atuam fortemente neste período e que podemos analisar através da cultura visual. Levaremos em consideração a localização da igreja em uma região de fronteira, para uma compreensão mais profunda dos elementos encontrados.

Japanese contributions to IAEA INTOR workshop, phase two A, part 2, chapter XI: concept evolution, chapter XII: design concept, and chapter XIII: operation and test programme

International Nuclear Information System (INIS)

Tomabechi, Ken; Fujisawa, Noboru; Iida, Hiromasa

1985-07-01

This report corresponds to Chapters XI, XII, and XIII of Japanese contribution report to IAEA INTOR Workship, Phase Two A, Part 2. In the phase Two A, Part 2 workshop, we have studied critical technical issues and have also assessed scientific and technical data bases. Based on those results, the INTOR design have been modified to upgrade the design concept. The major modification items are related to plasma beta value, plasma operation scenario, reactor size reduction, neutron fluence, tritium producing blanket, and implementation of active control coils. In those chapters, the concept evolution for the design modification and main results are described. (author)

Distribution and degradation of albumin in extensive skin disease

DEFF Research Database (Denmark)

Worm, Anne-Marie; Taaning, E; Rossing, N

1981-01-01

The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 132 I-labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus...... the observed hypoalbuminaemia and the low intravascular mass reflect a reduced mass of total body albumin. The rate of synthesis was normal, but the transcapillary escape rate reflecting the microvascular leakiness to macromolecules, and the fractional disappearance rate were significantly higher...

Estrategias territoriales de un poder monástico en la Galicia medieval: Celanova (siglos X-XII

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José Carlos SÁNCHEZ PARDO

2011-02-01

Full Text Available Se pretende afrontar un tema tradicional en la historiografía medieval española, como son los dominios monásticos, desde la perspectiva menos explorada de las estrategias espaciales que la reciente expansión del uso de los Sistemas de Información Geográfica ha facilitado. De esta manera, a través del caso gallego del monasterio de Celanova entre los siglos X y XII, observamos la complejidad que se esconde tras la planificación de la ubicación de uno de estos centros de poder así como la variedad y flexibilidad de tácticas empleadas en su proceso de crecimiento. Todo ello no solo enfatiza el conocido alto grado de conocimiento del entorno de los poderes señoriales entre finales de la Alta y Plena Edad Media, sino que también revela la importancia que dichos grupos daban a las estrategias espaciales en relación con la estructura preexistente de poblamiento y el papel que estas jugaron en el proceso de feudalización del noroeste peninsular.

Learning with distribution of optimized features for recognizing common CT imaging signs of lung diseases

Science.gov (United States)

Ma, Ling; Liu, Xiabi; Fei, Baowei

2017-01-01

Common CT imaging signs of lung diseases (CISLs) are defined as the imaging signs that frequently appear in lung CT images from patients. CISLs play important roles in the diagnosis of lung diseases. This paper proposes a novel learning method, namely learning with distribution of optimized feature (DOF), to effectively recognize the characteristics of CISLs. We improve the classification performance by learning the optimized features under different distributions. Specifically, we adopt the minimum spanning tree algorithm to capture the relationship between features and discriminant ability of features for selecting the most important features. To overcome the problem of various distributions in one CISL, we propose a hierarchical learning method. First, we use an unsupervised learning method to cluster samples into groups based on their distribution. Second, in each group, we use a supervised learning method to train a model based on their categories of CISLs. Finally, we obtain multiple classification decisions from multiple trained models and use majority voting to achieve the final decision. The proposed approach has been implemented on a set of 511 samples captured from human lung CT images and achieves a classification accuracy of 91.96%. The proposed DOF method is effective and can provide a useful tool for computer-aided diagnosis of lung diseases on CT images.

AN ANALYSIS OF STUDENTS’ ABILITY IN USING SUB-ORDINATE CONJUNCTION IN SENTENCE WRITING OF THE GRADE XII STUDENTS OF SMA N 2 METRO ACADEMIC YEAR 2013/2014

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Bambang Eko Siagianto

2017-02-01

Full Text Available Abstracts: Sub-ordinate conjunction is very confusing to comprehend by students. In using sub-ordinate conjunction, students usually had errors. The purpose of this research to analyze whether or not the students are able to use sub-ordinate conjunction in sentence writing, to classify kinds of sub-ordinate conjunction that was often misused by students in sentence writing The research was done at the grade XII of SMA N 2 Metro in second semester of the academic year 2013/2014. The predicted research findings are; the students cannot divide or difference the type of sub-ordinate conjunction well, and they often errors using it in sentences.The result of the students test in using sub-ordinate conjunction in sentence writing proves that most of the students at the grade XII of SMA N 2 Metro used the list of words “after, then, when, because” on their sentence writing. The students found these words easier to be used as conjunction especially sub-ordinate conjunction in their sentence writing than other conjunction. While, for other list of words doesn’t used by the students because the students cannot adapted the words in their sentence writing. The most familiar sub-ordinate conjunction seems to be  “before and since” (each of them is gained by 22 students = 91,6%, but the students are unfamiliar with the other words in sub-ordinate conjunction mainly “till and unless” (each of the is gained by 13 students = 54,1%. The other sub-ordinate conjunctions are quite familiar for them.

CT-clinical approach to patients with symptoms related to the V, VII, IX-XII cranial nerves and cervical sympathetics

International Nuclear Information System (INIS)

Kalovidouris, A.; Mancuso, A.A.; Dillon, W.

1984-01-01

Forty-three patients who had signs and symptoms possibly related to the extracranial course of cranial nerves V, VII, IX, X-XII, and the cervical sympathetics were examined prospectively using high resolution CT to obtain images of thin sections during rapid drip infusion of contrast material. Anatomic areas in the scan protocols included the posterior fossa, cavernous and paranasal sinuses, skull base, temporal bone, nasopharynx, parotid gland, tongue base, and neck. Nine of the 23 patients with possible fifth nerve deficits had extracranial structural lesions that explained the symptoms; none of these nine, however, had typical trigeminal neuralgia. Of eight patients with peripheral seventh nerve abnormalities, two had positive findings on scans. Of five patients presenting with referred ear pain, three had carcinoma of the upper aerodigestive tract. The authors' experience suggests that patients at high risk for structural lesions responsible for cranial nerve deficits can be selected by clinical criteria. Protocols for each clinical setting are presented

Pengaruh Kompetensi Pedagogik dan Kompetensi Profesional Guru terhadap Economic Literacy melalui Prestasi Belajar Siswa Kelas XII IPS di SMA Kota Malang

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Denik Wulandari

2013-10-01

Full Text Available Tujuan penelitian ini untuk menguji pengaruh (1 kompetensi pedagogik guru terhadap economic literacy melalui prestasi belajar siswa, (2 kompetensi profesional guru terhadap economic literacy melalui prestasi belajar siswa. Penelitian dilakukan terhadap siswa kelas XII IPS di SMA RSBI se-Kota Malang pada tahun 2012, data diperoleh dari angket, tes, dan dokumentasi. Hasil pene-litian: (1 kompetensi pedagogik guru berpengaruh positif signifikan terhadap economic literacy; (2 kompetensi pedagogik guru berpengaruh positif signifikan terhadap prestasi belajar; (3 prestasi belajar berpengaruh positif signifikan terhadap economic literacy; (4 kompetensi profesional guru berpengaruh positif signifikan terhadap economic literacy; dan (5 kompetensi profesional guru berpengaruh positif signifikan terhadap prestasi belajar. Berdasarkan hasil penelitian tersebut secara keseluruhan dapat diketahui bahwa kompetensi pedagogik dan kompetensi profesional guru dapat mempengaruhi economic literacy siswa melalui prestasi belajar siswa. Kata kunci: kompetensi pedagogik, kompetensi profesional, prestasi belajar, economic literacy

Thyroid volume in hypothyroidism due to autoimmune disease follows a unimodal distribution: evidence against primary thyroid atrophy and autoimmune thyroiditis being distinct diseases

DEFF Research Database (Denmark)

Carlé, Allan; Pedersen, Inge Bülow; Knudsen, Nils

2009-01-01

CONTEXT: Primary overt autoimmune hypothyroidism is often divided into primary idiopathic hypothyroidism with thyroid atrophy (Ord's disease) and hypothyroidism with goitre (Hashimoto's disease). OBJECTIVE: The aim of the present study was to characterize the two subtypes of disease. DESIGN...... program including thyroid ultrasonography and measurements of thyroid autoantibodies. Of the 144 patients investigated (58% of all invited), 139 were compared with 556 sex-, age-, and region-matched controls from the cohort. RESULTS: Patients had lower median (11.6 ml vs. 13.5 ml, P = 0.001) and a more...... dispersed distribution of thyroid volumes compared with controls (P thyroid volume showed a Gaussian distribution in both males and females with no bimodal pattern. Nearly all patients had measurable thyroid autoantibodies, but with increasing thyroid volume (quartile I, II, III, and IV...

Control of Vascular Streak Dieback Disease of Cocoa with Flutriafol Fungicides

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Febrilia Nur'aini

2014-12-01

Full Text Available Vascular streak dieback caused by the fungus Oncobasidium theobromae is one of the important diseases in cocoa crop in Indonesia. One approach to control the disease is by using fungicides. The aim of this research was to determine the effect of class triazole fungicides to the intensity of the vascular streak dieback disease on cocoa seedling phase, immature and mature cocoa. Experiments were conducted in Kotta Blater, PTPN XII and Kaliwining, Indonesian  Coffee and Cocoa Research Institute. Flutriafol 250 g/l with a concentration 0,05%, 0,1% and 0,15% foliar sprayed on cocoa seedlings, immature and mature cocoa. Active compound combination of Azoxystrobin and Difenoconazole with 0,1% concentration used as a comparation fungicides. The result showed that Flutriafol with 0,05%, 0,1% and 0,15% concentration and Azoxystrobin & Difenoconazol with 0,1% concentration could suppress the vascular streak dieback disease on seedlings. On immature plants, the application of Flutriafol was not effectively suppress the vascular streak dieback disease whereas the fungicide comparison could suppress with the efficacy level of 46.22%. On mature plants,both of fungicides could not suppress the vascular streak dieback disease. Key words: Fungicide, cocoa, vascular streak dieback, triazole, flutriafol, azoxystrobin+difenoconazol

Distribution of major health risks: findings from the Global Burden of Disease study.

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Anthony Rodgers

2004-10-01

Full Text Available Most analyses of risks to health focus on the total burden of their aggregate effects. The distribution of risk-factor-attributable disease burden, for example by age or exposure level, can inform the selection and targeting of specific interventions and programs, and increase cost-effectiveness.For 26 selected risk factors, expert working groups conducted comprehensive reviews of data on risk-factor exposure and hazard for 14 epidemiological subregions of the world, by age and sex. Age-sex-subregion-population attributable fractions were estimated and applied to the mortality and burden of disease estimates from the World Health Organization Global Burden of Disease database. Where possible, exposure levels were assessed as continuous measures, or as multiple categories. The proportion of risk-factor-attributable burden in different population subgroups, defined by age, sex, and exposure level, was estimated. For major cardiovascular risk factors (blood pressure, cholesterol, tobacco use, fruit and vegetable intake, body mass index, and physical inactivity 43%-61% of attributable disease burden occurred between the ages of 15 and 59 y, and 87% of alcohol-attributable burden occurred in this age group. Most of the disease burden for continuous risks occurred in those with only moderately raised levels, not among those with levels above commonly used cut-points, such as those with hypertension or obesity. Of all disease burden attributable to being underweight during childhood, 55% occurred among children 1-3 standard deviations below the reference population median, and the remainder occurred among severely malnourished children, who were three or more standard deviations below median.Many major global risks are widely spread in a population, rather than restricted to a minority. Population-based strategies that seek to shift the whole distribution of risk factors often have the potential to produce substantial reductions in disease burden.

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

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Srishti Singh

2018-04-01

Full Text Available Carbonic anhydrases (CAs catalyze the reversible hydration of carbon dioxide to produce bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases, including cancer. In solid tumors, continuously dividing cells create hypoxic conditions that eventually lead to an acidic microenvironment. Hypoxic tumor cells have different mechanisms in place to regulate and adjust the surrounding microenvironment for survival. These mechanisms include expression of CA isoform IX (CA IX and XII (CA XII. These enzymes help maintain a physiological intracellular pH while simultaneously contributing to an acidic extracellular pH, leading to tumor cell survival. Expression of CA IX and CA XII has also been shown to promote tumor cell invasion and metastasis. This review discusses the characteristics of CA IX and CA XII, their mechanism of action, and validates their prospective use as anticancer targets. We discuss the current status of small inhibitors that target these isoforms, both classical and non-classical, and their future design in order to obtain isoform-specificity for CA IX and CA XII. Biologics, such as monoclonal antibodies, monoclonal-radionuclide conjugated chimeric antibodies, and antibody-small molecule conjugates are also discussed.

Global burden, distribution, and interventions for infectious diseases of poverty.

Science.gov (United States)

Bhutta, Zulfiqar A; Sommerfeld, Johannes; Lassi, Zohra S; Salam, Rehana A; Das, Jai K

2014-01-01

Infectious diseases of poverty (IDoP) disproportionately affect the poorest population in the world and contribute to a cycle of poverty as a result of decreased productivity ensuing from long-term illness, disability, and social stigma. In 2010, the global deaths from HIV/AIDS have increased to 1.5 million and malaria mortality rose to 1.17 million. Mortality from neglected tropical diseases rose to 152,000, while tuberculosis killed 1.2 million people that same year. Substantial regional variations exist in the distribution of these diseases as they are primarily concentrated in rural areas of Sub-Saharan Africa, Asia, and Latin America, with geographic overlap and high levels of co-infection. Evidence-based interventions exist to prevent and control these diseases, however, the coverage still remains low with an emerging challenge of antimicrobial resistance. Therefore, community-based delivery platforms are increasingly being advocated to ensure sustainability and combat co-infections. Because of the high morbidity and mortality burden of these diseases, especially in resource-poor settings, it is imperative to conduct a systematic review to identify strategies to prevent and control these diseases. Therefore, we attempted to evaluate the effectiveness of one of these strategies, that is community-based delivery for the prevention and treatment of IDoP. In this paper, we describe the burden, epidemiology, and potential interventions for IDoP. In subsequent papers of this series, we describe the analytical framework and the methodology used to guide the systematic reviews, and report the findings and interpretations of our analyses of the impact of community-based strategies on individual IDoPs.

Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI

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Yousry, Indra; Yousry, Tarek A. [Department of Neuroradiology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich (Germany); Muacevic, Alexander; Olteanu-Nerbe, Vlad [Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians University, Munich (Germany); Naidich, Thomas P. [Department of Radiology, Section of Neuroradiology, Mount Sinai Hospital, New York (United States)

2004-07-01

We describe a rare case of adult pilocytic astrocytoma in which exophytic growth from the brain stem presented as a right cerebellopontine angle mass. An initial MRI examination using T2- and T1-weighted images without and with contrast suggested the diagnosis of schwannoma. Subsequent use of 3D CISS (three-dimensional constructive interference in steady state) and T1-weighted contrast-enhanced 3D MP-RAGE (three-dimensional magnetization prepared rapid acquisition gradient echo) sequences led to the diagnosis of an exophytic brain stem tumor, documented the precise relationships of the tumor to cranial nerve VIII, revealed encasement of cranial nerves IX-XII (later confirmed intraoperatively), and provided the proper basis for planning surgical management. (orig.)

Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI

International Nuclear Information System (INIS)

Yousry, Indra; Yousry, Tarek A.; Muacevic, Alexander; Olteanu-Nerbe, Vlad; Naidich, Thomas P.

2004-01-01

We describe a rare case of adult pilocytic astrocytoma in which exophytic growth from the brain stem presented as a right cerebellopontine angle mass. An initial MRI examination using T2- and T1-weighted images without and with contrast suggested the diagnosis of schwannoma. Subsequent use of 3D CISS (three-dimensional constructive interference in steady state) and T1-weighted contrast-enhanced 3D MP-RAGE (three-dimensional magnetization prepared rapid acquisition gradient echo) sequences led to the diagnosis of an exophytic brain stem tumor, documented the precise relationships of the tumor to cranial nerve VIII, revealed encasement of cranial nerves IX-XII (later confirmed intraoperatively), and provided the proper basis for planning surgical management. (orig.)

Interpreting predictive maps of disease: highlighting the pitfalls of distribution models in epidemiology

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Nicola A. Wardrop

2014-11-01

Full Text Available The application of spatial modelling to epidemiology has increased significantly over the past decade, delivering enhanced understanding of the environmental and climatic factors affecting disease distributions and providing spatially continuous representations of disease risk (predictive maps. These outputs provide significant information for disease control programmes, allowing spatial targeting and tailored interventions. However, several factors (e.g. sampling protocols or temporal disease spread can influence predictive mapping outputs. This paper proposes a conceptual framework which defines several scenarios and their potential impact on resulting predictive outputs, using simulated data to provide an exemplar. It is vital that researchers recognise these scenarios and their influence on predictive models and their outputs, as a failure to do so may lead to inaccurate interpretation of predictive maps. As long as these considerations are kept in mind, predictive mapping will continue to contribute significantly to epidemiological research and disease control planning.

“Et qui or me vaurra entendre, cuer et oreilles me doit rendre”: espacios de lectura y público de los roman courtois de Chrétien de Troyes (siglos XII-XIII

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Diego Carlo Améndolla Spinola

2016-06-01

Full Text Available Basado en los planteamientos de la lógica social del texto, este artículo presenta un estudio del público que escuchaba los romances corteses entre los siglo XII y XIII, específicamente los realizados por Chrétien de Troyes –clérigo lector de la Corte de Leonor de Aquitania y de Enrique II Plantagenet–, además de establecer y analizar las diversas salas de los castillos donde estas obras literarias eran narradas.

The distribution and symptomatology of grapevine trunk disease pathogens are influenced by climate

NARCIS (Netherlands)

van Niekerk, J.M.; Bester, W.; Halleen, F.; Crous, P.W.; Fourie, P.H.

2011-01-01

Grapevine trunk diseases, caused by a range of phytopathogenic fungi, represent a serious impediment to wine and table grape production wherever these crops are cultivated. Previous studies have shown that the distribution of these pathogens is influenced by climate and that they are associated with

MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease.

Science.gov (United States)

Foley, Desmond H; Wilkerson, Richard C; Birney, Ian; Harrison, Stanley; Christensen, Jamie; Rueda, Leopoldo M

2010-02-18

Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

PENGARUH PERSEPSI SISWA TENTANG KOMPETENSI KEJURUAN, PENGUASAAN SOFT SKILL, DAN KEMATANGAN KARIR TERHADAP KESIAPAN KERJA SISWA KELAS XII AKUNTANSI SMK NEGERI 2 MAGELANG TAHUN AJARAN 2014/2015

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Riska Afriani

2015-06-01

Full Text Available Berdasarkan observasi awal, diketahui bahwa belum semua siswa kelas XII Akuntansi mempunyai kesiapan kerja tinggi. Hal ini terlihat pada keterserapan lulusan pada tahun 2014 hanya sebesar 54% dari keseluruhan lulusan. Penelitian ini bertujuan untuk mengetahui adakah pengaruh persepsi siswa tentang kompetensi kejuruan, penguasaan soft skill, dan kematangan karir terhadap kesiapan kerja. Populasi penelitian ini adalah siswa kelas XII Akuntansi SMK Negeri 2 Magelang tahun ajaran 2014/2015. Berdasarkan rumus Isaac dan Michael, sampel sebanyak 84 siswa diambil sampel per kelas menggunakan teknik proportional random sampling.Metode pengumpulan data menggunakan angket. metode analisis data yang digunakan adalah analisis deskriptif dan analisis regresi berganda. Analisis deskriptif diperoleh bahwa kesiapan kerja siswa dalam kategori Siap, Persepsi Siswa tentang Kompetensi Kejuruan dalam kategori Baik, Penguasaan Soft Skill dalam kategori Baik, dan Kematangan Karir dalam kategori Matang. Hasil penelitian ini secara statistik menunjukkan bahwa terdapat pengaruh persepsi siswa tentang kompetensi kejuruan terhadap kesiapan kerja sebesar 19,9%, penguasaan soft skill terhadap kesiapan kerja sebesar 5,8%, dan kematangan karir terhadap kesiapan kerja sebesar 9,8%. Berdasarkan hasil penelitian di atas, dapat disimpulkan bahwa persepsi siswa tentang kompetensi kejuruan, penguasaan soft skill, dan kematangan karirberpengaruh terhadap kesiapan kerja. Saran yang diberikan, untuk meningkatkan kesiapan kerja siswa, hendaknya siswa diberikan pemahaman yang baik tentang kompetensi akuntansi, pelatihan soft skill, dan bimbingan karir. Based on initial observation, known that not all student on twelfth grade accounting have a high work readiness. This is shown by graduate occupancy to work in 2014 just 54% of all. The purpose of this research are to see the influence of Students Perception about Vocational Competency, Soft Skill Capability and Career Maturity toward Work

Celiac Family Health Education Video Series

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Full Text Available ... School Eating Out Away From Home Emotional Adjustment Kids Speak Research and Innovation Contact Us Celiac Disease ... Support Group : Resources and support for families. XII. Kids Speak : What kids with celiac disease have to ...

Targeting hunter distribution based on host resource selection and kill sites to manage disease risk.

Science.gov (United States)

Dugal, Cherie J; van Beest, Floris M; Vander Wal, Eric; Brook, Ryan K

2013-10-01

Endemic and emerging diseases are rarely uniform in their spatial distribution or prevalence among cohorts of wildlife. Spatial models that quantify risk-driven differences in resource selection and hunter mortality of animals at fine spatial scales can assist disease management by identifying high-risk areas and individuals. We used resource selection functions (RSFs) and selection ratios (SRs) to quantify sex- and age-specific resource selection patterns of collared (n = 67) and hunter-killed (n = 796) nonmigratory elk (Cervus canadensis manitobensis) during the hunting season between 2002 and 2012, in southwestern Manitoba, Canada. Distance to protected area was the most important covariate influencing resource selection and hunter-kill sites of elk (AICw = 1.00). Collared adult males (which are most likely to be infected with bovine tuberculosis (Mycobacterium bovis) and chronic wasting disease) rarely selected for sites outside of parks during the hunting season in contrast to adult females and juvenile males. The RSFs showed selection by adult females and juvenile males to be negatively associated with landscape-level forest cover, high road density, and water cover, whereas hunter-kill sites of these cohorts were positively associated with landscape-level forest cover and increasing distance to streams and negatively associated with high road density. Local-level forest was positively associated with collared animal locations and hunter-kill sites; however, selection was stronger for collared juvenile males and hunter-killed adult females. In instances where disease infects a metapopulation and eradication is infeasible, a principle goal of management is to limit the spread of disease among infected animals. We map high-risk areas that are regularly used by potentially infectious hosts but currently underrepresented in the distribution of kill sites. We present a novel application of widely available data to target hunter distribution based on host resource

Quantifying the pattern of beta/A4 amyloid protein distribution in Alzheimer's disease by image analysis.

Science.gov (United States)

Bruce, C V; Clinton, J; Gentleman, S M; Roberts, G W; Royston, M C

1992-04-01

We have undertaken a study of the distribution of the beta/A4 amyloid deposited in the cerebral cortex in Alzheimer's disease. Previous studies which have examined the differential distribution of amyloid in the cortex in order to determine the laminar pattern of cortical pathology have not proved to be conclusive. We have developed an alternative method for the solution of this problem. It involves the immunostaining of sections followed by computer-enhanced image analysis. A mathematical model is then used to describe both the amount and the pattern of amyloid across the cortex. This method is both accurate and reliable and also removes many of the problems concerning inter and intra-rater variability in measurement. This method will provide the basis for further quantitative studies on the differential distribution of amyloid in Alzheimer's disease and other cases of dementia where cerebral amyloidosis occurs.

Global Dynamics of Infectious Disease with Arbitrary Distributed Infectious Period on Complex Networks

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Xiaoguang Zhang

2014-01-01

Full Text Available Most of the current epidemic models assume that the infectious period follows an exponential distribution. However, due to individual heterogeneity and epidemic diversity, these models fail to describe the distribution of infectious periods precisely. We establish a SIS epidemic model with multistaged progression of infectious periods on complex networks, which can be used to characterize arbitrary distributions of infectious periods of the individuals. By using mathematical analysis, the basic reproduction number R0 for the model is derived. We verify that the R0 depends on the average distributions of infection periods for different types of infective individuals, which extend the general theory obtained from the single infectious period epidemic models. It is proved that if R0<1, then the disease-free equilibrium is globally asymptotically stable; otherwise the unique endemic equilibrium exists such that it is globally asymptotically attractive. Finally numerical simulations hold for the validity of our theoretical results is given.

Grapevine yellows diseases in Spain: eight year survey of disease spread and molecular characterization of phytoplasmas involved

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Torres, Ester

2005-12-01

Full Text Available Among grapevine yellows phytoplasma diseases in Europe, flavescence dorée (FD is the most devastating and in the last decade has reached Spanish vineyards, mainly in Catalonia. An eight-year survey was carried out in the areas where the disease has spread (Alt Empordà, Catalonia, Northern Spain and in the remaining vine-growing areas of Catalonia. Sequence analyses of a portion of the 16S-23S ribosomal DNA cistron, from selected grapevine samples from Catalonia, showed that the phytoplasmas involved in grapevine yellows belong to 16S ribosomal subgroups V-D (flavescence dorée, FD and XII-A (bois noir, BN. A set of Spanish FD isolates collected during these years were further studied by RFLP analyses of the 16S-23S ribosomal DNA fragment, as well as the rpS3 and SecY genes. All the FD phytoplasma strains studied were related to phytoplasmas belonging to ribosomal protein subgroup rp-E.La flavescencia dorada (FD es la enfermedad más agresiva de entre todas las enfermedades de fitoplasmas que causan amarilleos de vid en Europa, y que en la última década ha alcanzado también a los viñedos de España, principalmente en Cataluña. Se ha realizado un seguimiento durante ocho años en las zonas donde la enfermedad se había difundido (Alt Empordà, Cataluña y en el resto de zonas con cultivo de vid de Cataluña. El análisis del fragmento del gen DNA ribosomal 16S-23S, de una selección de muestras de vides de Cataluña, indica que los fitoplasmas que están implicados en los amarilleos de vid pertenecen a los subgrupos ribosomales 16S V-D (flavescencia dorada, FD y XII-A (bois noir, BN. Una selección de aislados españoles de FD obtenidos durante estos años se ha examinado mediante análisis RFLP del fragmento del gen ribosomal 16S-23S, y de los genes rpS3 y SecY. Todos los aislamientos de fitoplasmas FD estudiados están relacionados con fitoplasmas pertenecientes al subgrupo de proteína ribosomal rp-E.

Incidencia del aprendizaje cooperativo en el área de Lenguaje y Comunicación en el séptimo año de la escuela Pío XII periodo lectivo 2007-2008

OpenAIRE

Alvarez Carvajal, Esthela del Rocío; Robles Tenorio, Mercy Cristina

2007-01-01

Lo que recoge este documento va dirigido al aprendizaje desde un punto de vista cooperativo como parte de la formación integral del alumnado de la escuela PIO XII. Por lo que consideramos fundamental al aprendizaje cooperativo como: una estrategia de enseñanza exitosa en la que pequeños grupos, cada uno con estudiantes de diferentes niveles de habilidad usan una variedad de actividades de aprendizaje para mejorar su comprensión de un tema. Cada miembro de un equipo es responsable no sólo de a...

Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer's Disease Patients

NARCIS (Netherlands)

Rueb, Udo; Stratmann, Katharina; Heinsen, Helmut; Del Turco, Domenico; Ghebremedhin, Estifanos; Seidel, Kay; den Dunnen, Wilfred; Korf, Horst-Werner

2015-01-01

In spite of considerable progress in neuropathological research on Alzheimer's disease (AD), knowledge regarding the exact pathoanatomical distribution of the tau cytoskeletal pathology in the thalamus of AD patients in the advanced Braak and Braak AD stages V or VI of the cortical cytoskeletal

Explorer-II: Wireless Self-Powered Visual and NDE Robotic Inspection System for Live Gas Distribution Mains

Energy Technology Data Exchange (ETDEWEB)

Carnegie Mellon University

2008-09-30

Carnegie Mellon University (CMU) under contract from Department of Energy/National Energy Technology Laboratory (DoE/NETL) and co-funding from the Northeast Gas Association (NGA), has completed the overall system design, field-trial and Magnetic Flux Leakage (MFL) sensor evaluation program for the next-generation Explorer-II (X-II) live gas main Non-destructive Evaluation (NDE) and visual inspection robot platform. The design is based on the Explorer-I prototype which was built and field-tested under a prior (also DoE- and NGA co-funded) program, and served as the validation that self-powered robots under wireless control could access and navigate live natural gas distribution mains. The X-II system design ({approx}8 ft. and 66 lbs.) was heavily based on the X-I design, yet was substantially expanded to allow the addition of NDE sensor systems (while retaining its visual inspection capability), making it a modular system, and expanding its ability to operate at pressures up to 750 psig (high-pressure and unpiggable steel-pipe distribution mains). A new electronics architecture and on-board software kernel were added to again improve system performance. A locating sonde system was integrated to allow for absolute position-referencing during inspection (coupled with external differential GPS) and emergency-locating. The power system was upgraded to utilize lithium-based battery-cells for an increase in mission-time. The resulting robot-train system with CAD renderings of the individual modules. The system architecture now relies on a dual set of end camera-modules to house the 32-bit processors (Single-Board Computer or SBC) as well as the imaging and wireless (off-board) and CAN-based (on-board) communication hardware and software systems (as well as the sonde-coil and -electronics). The drive-module (2 ea.) are still responsible for bracing (and centering) to drive in push/pull fashion the robot train into and through the pipes and obstacles. The steering modules

The Joint International Conference of the XII International Conference on Mechanisms and Mechanical Transmissions (MTM) and the XXIII International Conference on Robotics (Robotics ’16)

CERN Document Server

Lovasz, Erwin-Christian; Hüsing, Mathias; Maniu, Inocentiu; Gruescu, Corina

2017-01-01

This volume presents the proceedings of the Joint International Conference of the XII International Conference on Mechanisms and Mechanical Transmissions (MTM) and the XXIII International Conference on Robotics (Robotics ’16), that was held in Aachen, Germany, October 26th-27th, 2016. It contains applications of mechanisms and transmissions in several modern technical fields such as mechatronics, biomechanics, machines, micromachines, robotics and apparatus. In connection with these fields, the work combines the theoretical results with experimental testing. The book presents reviewed papers developed by researchers specialized in mechanisms analysis and synthesis, dynamics of mechanisms and machines, mechanical transmissions, biomechanics, precision mechanics, mechatronics, micromechanisms and microactuators, computational and experimental methods, CAD in mechanism and machine design, mechanical design of robot architecture, parallel robots, mobile robots, micro and nano robots, sensors and actuators in ro...

Potential worldwide distribution of Fusarium dry root rot in common beans based on the optimal environment for disease occurrence.

Science.gov (United States)

Macedo, Renan; Sales, Lilian Patrícia; Yoshida, Fernanda; Silva-Abud, Lidianne Lemes; Lobo, Murillo

2017-01-01

Root rots are a constraint for staple food crops and a long-lasting food security problem worldwide. In common beans, yield losses originating from root damage are frequently attributed to dry root rot, a disease caused by the Fusarium solani species complex. The aim of this study was to model the current potential distribution of common bean dry root rot on a global scale and to project changes based on future expectations of climate change. Our approach used a spatial proxy of the field disease occurrence, instead of solely the pathogen distribution. We modeled the pathogen environmental requirements in locations where in-situ inoculum density seems ideal for disease manifestation. A dataset of 2,311 soil samples from commercial farms assessed from 2002 to 2015 allowed us to evaluate the environmental conditions associated with the pathogen's optimum inoculum density for disease occurrence, using a lower threshold as a spatial proxy. We encompassed not only the optimal conditions for disease occurrence but also the optimal pathogen's density required for host infection. An intermediate inoculum density of the pathogen was the best disease proxy, suggesting density-dependent mechanisms on host infection. We found a strong convergence on the environmental requirements of both the host and the disease development in tropical areas, mostly in Brazil, Central America, and African countries. Precipitation and temperature variables were important for explaining the disease occurrence (from 17.63% to 43.84%). Climate change will probably move the disease toward cooler regions, which in Brazil are more representative of small-scale farming, although an overall shrink in total area (from 48% to 49% in 2050 and 26% to 41% in 2070) was also predicted. Understanding pathogen distribution and disease risks in an evolutionary context will therefore support breeding for resistance programs and strategies for dry root rot management in common beans.

Potential worldwide distribution of Fusarium dry root rot in common beans based on the optimal environment for disease occurrence.

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Renan Macedo

Full Text Available Root rots are a constraint for staple food crops and a long-lasting food security problem worldwide. In common beans, yield losses originating from root damage are frequently attributed to dry root rot, a disease caused by the Fusarium solani species complex. The aim of this study was to model the current potential distribution of common bean dry root rot on a global scale and to project changes based on future expectations of climate change. Our approach used a spatial proxy of the field disease occurrence, instead of solely the pathogen distribution. We modeled the pathogen environmental requirements in locations where in-situ inoculum density seems ideal for disease manifestation. A dataset of 2,311 soil samples from commercial farms assessed from 2002 to 2015 allowed us to evaluate the environmental conditions associated with the pathogen's optimum inoculum density for disease occurrence, using a lower threshold as a spatial proxy. We encompassed not only the optimal conditions for disease occurrence but also the optimal pathogen's density required for host infection. An intermediate inoculum density of the pathogen was the best disease proxy, suggesting density-dependent mechanisms on host infection. We found a strong convergence on the environmental requirements of both the host and the disease development in tropical areas, mostly in Brazil, Central America, and African countries. Precipitation and temperature variables were important for explaining the disease occurrence (from 17.63% to 43.84%. Climate change will probably move the disease toward cooler regions, which in Brazil are more representative of small-scale farming, although an overall shrink in total area (from 48% to 49% in 2050 and 26% to 41% in 2070 was also predicted. Understanding pathogen distribution and disease risks in an evolutionary context will therefore support breeding for resistance programs and strategies for dry root rot management in common beans.

XII Encuentro Científico “Desarrollo, innovación y salud”

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Luis Alberto Gómez

2011-08-01

componentes complementarios de la totalidad de las evidencias que permiten entender los determinantes de un estado de salud o de enfermedad. Los progresos en la definición de la relación de un evento biológico, ambiental, nutricional o social con el riesgo de desarrollar una enfermedad, están orientados por los desarrollos científicos y tecnológicos, así como por su incorporación en los bienes y servicios. En este escenario tan complejo, y para enfrentar los problemas actuales y por venir, la investigación científica en salud es una de las áreas de desarrollo con una gran responsabilidad de generar conocimiento científico, que permita orientar y proponer diferentes estrategias para atender problemas nuevos y futuros. La generación y la gestión del conocimiento en salud, como un factor de desarrollo y transformación del mundo moderno, determina que el Instituto Nacional de Salud, esté asumiendo un papel de liderazgo en la producción de ciencia y tecnología e innovación para contribuir a resolver problemas de salud, en concordancia con la realidad y las necesidades nacionales e internacionales. El Instituto Nacional de Salud ocupa una posición especial para dirigir y coordinar los esfuerzos colectivos e impulsar los cambios necesarios para aumentar la capacidad de investigación en salud, entre otros procesos de desarrollo. Con el objetivo de proporcionar un espacio para difundir la producción científico-técnica reciente en el campo de la salud humana, así como de promover y orientar la cooperación y transferencia de ciencia, tecnología e innovación en salud, el Instituto Nacional de Salud realiza el XII Encuentro Científico. En este encuentro se presentan algunos de los avances de las líneas institucionales y de los proyectos de investigación, con la participación de investigadores del Instituto y de algunos invitados nacionales e internacionales. Entre las principales áreas temáticas que se desarrollan se incluyen: redes y desarrollo en salud

β-THALASSEMIA DISTRIBUTION IN THE OLD WORLD: A HISTORICAL STANDPOINT OF AN ANCIENT DISEASE

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Vincenzo De Sanctis

2017-02-01

Full Text Available Abstract Background: Haemoglobinopathies constitute the commonest recessive monogenic disorders worldwide, and the treatment of affected individuals presents a substantial global disease burden. β -thalassaemia is characterised by the reduced synthesis (β + or absence (β o of the β-globin chains in the HbA molecule, resulting in accumulation of  excess unbound α-globin chains that precipitate in erythroid precursors in the bone marrow and in the mature erythrocytes, leading to ineffective erythropoiesis and peripheral haemolysis. Approximately 1.5% of the global population are heterozygotes (carriers of the β-thalassemias: there is a high incidence in populations extending from the Mediterranean basin throughout the Middle East, the Indian subcontinent, Southeast Asia, Melanesia and into the Pacific Islands Aim: The principal aim of this paper is to review, from a historical standpoint, our knowledge about an ancient disease, the β-thalassemias, and  in particular, when, how and in what way β-thalassemia spread worldwide to reach such high incidences in certain populations.     Results: Mutations involving the ß-globin gene are the most common cause of genetic disorders  in humans. To date, more than 350 β -thalassaemia mutations have been reported. Considering the current distribution of β- thalassemia, the wide diversity of mutations and the small number of individual population’s specific mutations, it seems unlikely that β-thalassemia originated in a single place and time. Conclusions: Various processes are known to determine the frequency of genetic disease in human populations. However, it is almost impossible to decide to what extent each process is responsible for the presence of a particular genetic disease. The wide spectrum of β-thalassemia mutations could well be explained by looking at its geographical distribution, the history of malaria, wars, invasions, mass migrations, consanguinity and settlements. The

Homens de letras e homens de leis ao serviço da monarquia portuguesa (séculos XII-XIII

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Armando Norte

2014-06-01

Full Text Available Ao longo da primeira dinastia, os letrados ao serviço da Coroa portuguesa desempenharam um papel decisivo e cada vez mais importante na afirmação do poder real. Homens de leis e homens de letras serviram à casa real como oficiais, representaram os reis portugueses em atos políticos e diplomáticos e exerceram um grande leque de funções na esfera da administração central - políticas, jurídicas, médicas, económicas, administrativas. A presença desses elementos ao lado dos monarcas fez-se sentir desde a fundação do reino, logo desde o reinado de D. Afonso Henriques, coincidindo o corolário deste processo de recrutamento com a chegada de D. Afonso III ao trono, numa política continuada, de forma firme, por D. Dinis. O conjunto de eruditos recenseados junto dos reis portugueses da época fundacional constitui, nessa medida, um interessante estudo de caso para compreender, em parte, em que consistia um círculo áulico, à luz dos valores do século XII e XIII.

Hubungan Asupan Energi Sarapan terhadap Tingkat Konsentrasi pada Siswa-Siswi Kelas XII SMA Negeri 1 Padang Tahun Ajaran 2013/2014

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Kurnia Maidarmi Handayani

2014-09-01

Full Text Available AbstrakIndonesia menduduki peringkat terakhir dalam cognitive skills dan pencapaian pendidikan menurut penelitian yang dilakukan oleh Economist Intelligence Unit. Cognitive skills memerlukan fungsi otak yang adekuat yang dipertahankan oleh nutrisi berupa konsumsi pangan yang baik dan beragam, terutama sarapan. Penelitian di Amerika Serikat pada anak usia sekolah remaja (15-18 tahun menunjukkan bahwa sebesar 30% remaja tidak biasa sarapan. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan energi sarapan dan tingkat konsentrasi pada siswa SMAN 1 Padang. Studi dilakukan di SMAN 1 Padang pada bulan November 2013 terhadap 116 siswa kelas XII. Desain penelitian bersifat analitik dengan desain cross sectional. Pengolahan data dilakukan dengan uji chi-square menggunakan sistem komputerisasi. Hasil penelitian menunjukkan terdapat perbedaan tingkat konsentrasi menggunakan digit symbol test antara siswa dengan asupan energi sarapan baik, kurang, dan sangat kurang (p=0,001 dan tidak terdapat perbedaan tingkat konsentrasi menggunakan digit span test antara siswa dengan asupan energi sarapan baik, kurang, dan sangat kurang (p=0,345. Terdapat hubungan yang bermakna antara asupan energi sarapan dengan tingkat konsentrasi menggunakan digit symbol test (p<0,05.Kata kunci: sarapan, asupan energi, konsentrasi, digit symbol test, digit span testAbstractIndonesia was ranked last in the cognitive skills and educational attainment according to research conducted by the Economist Intelligence Unit.Cognitive skills require brain function is maintained by adequate intake of nutrients such as good and varied food, especially breakfast. Research in the United States in children of school age youth (15-18 years showed that 30% of teenagers are not usually did breakfast.This study aimed to determine the relationship between energy intake at breakfast and the level of concentration of students of SMAN 1 Padang. The study was conducted at SMAN 1 Padang in

Prevalence and global initiative for chronic obstructive lung disease group distribution of chronic obstructive pulmonary disease detected by preoperative pulmonary function test.

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Sun Mi Choi

Full Text Available Despite being a major public health problem, chronic obstructive pulmonary disease (COPD remains underdiagnosed, and only 2.4% COPD patients are aware of their disease in Korea. The objective of this study was to estimate the prevalence of COPD detected by spirometry performed as a preoperative screening test and to determine the Global Initiative for Chronic Obstructive Lung Disease (GOLD group distribution and self-awareness of COPD.We reviewed the medical records of adults (age, ≥ 40 years who had undergone spirometry during preoperative screening between April and August 2013 at a tertiary hospital in Korea. COPD was defined as a postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratio of 40 years who had undergone spirometry as a preoperative screening test, 474 (15.6%; 404 men; median age, 70 years; range, 44-93 years were diagnosed with COPD. Only 26 (5.5% patients reported previous diagnosis of COPD (2.1%, emphysema (0.8%, or chronic bronchitis (2.5%. The GOLD group distribution was as follows: 63.3% in group A, 31.2% in group B, 1.7% in group C, and 3.8% in group D.The prevalence of COPD diagnosed by preoperative spirometry was 15.6%, and only 5.5% patients were aware of their disease. Approximately one-third of the COPD patients belonged to GOLD groups B, C, and D, which require regular treatment.

Distribution and characteristics of occupational injuries and diseases among farmers: a retrospective analysis of workers' compensation claims.

Science.gov (United States)

Karttunen, Janne P; Rautiainen, Risto H

2013-08-01

Research indicates occupational injuries and diseases are not evenly distributed among workers. We investigated the distribution and characteristics of compensated occupational injuries and diseases requiring medical care in the Finnish farming population. The study population consisted of 93,564 Finnish farmers, spouses, and salaried family members who were covered by the mandatory workers' compensation insurance in 2002. This population had a total of 133,207 occupational injuries and 9,148 occupational diseases over a 26-year period (1982-2008). Clustering of claims was observed. Nearly half (47.1%) of the population had no compensated claims while 52.9% had at least one; 50.9% of farmers had one or more injuries and 8.1% had one or more diseases. Ten percent of the population had half of injury cases, and 3% of the population had half of occupational disease cases. Claims frequently involved work tasks related to animal husbandry and repair and maintenance of farm machinery. Injury and disease characteristics (work activity, cause, ICD-10 code) differed between individuals with high and low personal claim rate. Injuries and diseases of the musculoskeletal system had a tendency to reoccur among those with high claim rate. These outcomes were often related to strenuous working motions and postures in labor-intensive animal husbandry. Analyses of longitudinal insurance data contributes to better understanding of the long-term risk of occupational injury and disease among farmers. We suggest focusing on recurrent health outcomes and their causes among high risk populations could help design more effective interventions in agriculture and other industries. Copyright © 2013 Wiley Periodicals, Inc.

Targeting hunter distribution based on host resource selection and kill sites to manage disease risk

DEFF Research Database (Denmark)

Dugal, Cherie; van Beest, Floris; Vander Wal, Eric

2013-01-01

Endemic and emerging diseases are rarely uniform in their spatial distribution or prevalence among cohorts of wildlife. Spatial models that quantify risk-driven differences in resource selection and hunter mortality of animals at fine spatial scales can assist disease management by identifying high-risk...... areas and individuals. We used resource selection functions (RSFs) and selection ratios (SRs) to quantify sex- and age-specific resource selection patterns of collared (n = 67) and hunter-killed (n = 796) nonmigratory elk (Cervus canadensis manitobensis) during the hunting season between 2002 and 2012...... juvenile males and hunter-killed adult females. In instances where disease infects a metapopulation and eradication is infeasible, a principle goal of management is to limit the spread of disease among infected animals. We map high-risk areas that are regularly used by potentially infectious hosts...

Vessel Wall Inflammation of Takayasu Arteritis Detected by Contrast-Enhanced Magnetic Resonance Imaging: Association with Disease Distribution and Activity.

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Yoko Kato

Full Text Available The assessment of the distribution and activity of vessel wall inflammation is clinically important in patients with Takayasu arteritis. Magnetic resonance imaging (MRI is a useful tool, but the clinical utility of late gadolinium enhancement (LGE in Takayasu arteritis has yet to be determined. The aim of the present study was to evaluate the utility of LGE in assessing vessel wall inflammation and disease activity in Takayasu arteritis.We enrolled 49 patients with Takayasu arteritis who had undergone 1.5 T MRI. Patients were divided into Active (n = 19 and Inactive disease (n = 30 groups. The distribution of vessel wall inflammation using angiography and LGE was assessed by qualitative analysis. In 79% and 63% of patients in Active and Inactive groups, respectively, greater distribution of vessel wall inflammation was observed with LGE than with conventional angiography. MRI values of pre- and post-contrast signal-to-noise ratios (SNR, SNR increment (post-SNR minus pre-SNR, pre- and post-contrast contrast-to-noise ratios (CNR, and CNR increment (post-CNR minus pre-CNR were evaluated at arterial wall sites with the highest signal intensity using quantitative analysis of post-contrast LGE images. No statistically significant differences in MRI parameters were observed between Active and Inactive groups. Contrast-enhanced MRI was unable to accurately detect active disease.Contrast-enhanced MRI has utility in detecting the distribution of vessel wall inflammation but has less utility in assessing disease activity in Takayasu arteritis.

Predicting distribution of Aedes aegypti and Culex pipiens complex, potential vectors of Rift Valley fever virus in relation to disease epidemics in East Africa

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Clement Nyamunura Mweya

2013-10-01

Full Text Available Background: The East African region has experienced several Rift Valley fever (RVF outbreaks since the 1930s. The objective of this study was to identify distributions of potential disease vectors in relation to disease epidemics. Understanding disease vector potential distributions is a major concern for disease transmission dynamics. Methods: Diverse ecological niche modelling techniques have been developed for this purpose: we present a maximum entropy (Maxent approach for estimating distributions of potential RVF vectors in un-sampled areas in East Africa. We modelled the distribution of two species of mosquitoes (Aedes aegypti and Culex pipiens complex responsible for potential maintenance and amplification of the virus, respectively. Predicted distributions of environmentally suitable areas in East Africa were based on the presence-only occurrence data derived from our entomological study in Ngorongoro District in northern Tanzania. Results: Our model predicted potential suitable areas with high success rates of 90.9% for A. aegypti and 91.6% for C. pipiens complex. Model performance was statistically significantly better than random for both species. Most suitable sites for the two vectors were predicted in central and northwestern Tanzania with previous disease epidemics. Other important risk areas include western Lake Victoria, northern parts of Lake Malawi, and the Rift Valley region of Kenya. Conclusion: Findings from this study show distributions of vectors had biological and epidemiological significance in relation to disease outbreak hotspots, and hence provide guidance for the selection of sampling areas for RVF vectors during inter-epidemic periods.

Predicting distribution of Aedes aegypti and Culex pipiens complex, potential vectors of Rift Valley fever virus in relation to disease epidemics in East Africa.

Science.gov (United States)

Mweya, Clement Nyamunura; Kimera, Sharadhuli Iddi; Kija, John Bukombe; Mboera, Leonard E G

2013-01-01

The East African region has experienced several Rift Valley fever (RVF) outbreaks since the 1930s. The objective of this study was to identify distributions of potential disease vectors in relation to disease epidemics. Understanding disease vector potential distributions is a major concern for disease transmission dynamics. DIVERSE ECOLOGICAL NICHE MODELLING TECHNIQUES HAVE BEEN DEVELOPED FOR THIS PURPOSE: we present a maximum entropy (Maxent) approach for estimating distributions of potential RVF vectors in un-sampled areas in East Africa. We modelled the distribution of two species of mosquitoes (Aedes aegypti and Culex pipiens complex) responsible for potential maintenance and amplification of the virus, respectively. Predicted distributions of environmentally suitable areas in East Africa were based on the presence-only occurrence data derived from our entomological study in Ngorongoro District in northern Tanzania. Our model predicted potential suitable areas with high success rates of 90.9% for A. aegypti and 91.6% for C. pipiens complex. Model performance was statistically significantly better than random for both species. Most suitable sites for the two vectors were predicted in central and northwestern Tanzania with previous disease epidemics. Other important risk areas include western Lake Victoria, northern parts of Lake Malawi, and the Rift Valley region of Kenya. Findings from this study show distributions of vectors had biological and epidemiological significance in relation to disease outbreak hotspots, and hence provide guidance for the selection of sampling areas for RVF vectors during inter-epidemic periods.

Analysis of the electric field distribution in the diseased ovaries of cows

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Вадим Сергеевич Попрядухин

2017-01-01

Full Text Available  This article is focused on solving the problem of the electromagnetic radiation distribution inside the ovaries of cattle. As a result of theoretical studies integral equation was obtained based on vector fields and integral formulas of vector field theory. Solving of the equation allowed to obtain formulas for the calculation of the electric field mean value inside of diseased ovaries. Mean value of the electric field is necessary for calculation of biotropic parameters for treatment of inflammation of ovaries

Effects of extreme precipitation to the distribution of infectious diseases in Taiwan, 1994-2008.

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Mu-Jean Chen

Full Text Available The incidence of extreme precipitation has increased with the exacerbation of worldwide climate disruption. We hypothesize an association between precipitation and the distribution patterns that would affect the endemic burden of 8 infectious diseases in Taiwan, including water- and vector-borne infectious diseases. A database integrating daily precipitation and temperature, along with the infectious disease case registry for all 352 townships in the main island of Taiwan was analysed for the period from 1994 to 2008. Four precipitation levels, 350 mm, were categorized to represent quantitative differences, and their associations with each specific disease was investigated using the Generalized Additive Mixed Model and afterwards mapped on to the Geographical Information System. Daily precipitation levels were significantly correlated with all 8 mandatory-notified infectious diseases in Taiwan. For water-borne infections, extreme torrential precipitation (>350 mm/day was found to result in the highest relative risk for bacillary dysentery and enterovirus infections when compared to ordinary rain (<130 mm/day. Yet, for vector-borne diseases, the relative risk of dengue fever and Japanese encephalitis increased with greater precipitation only up to 350 mm. Differential lag effects following precipitation were statistically associated with increased risk for contracting individual infectious diseases. This study's findings can help health resource sector management better allocate medical resources and be better prepared to deal with infectious disease outbreaks following future extreme precipitation events.

Heartworm disease (Dirofilaria immitis and their vectors in Europe. New distribution trends.

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Rodrigo eMorchón

2012-06-01

Full Text Available Cardiopulmonary dirofilariasis is a cosmopolitan disease caused by Dirofilaria immitis, which affects mainly canids and felids. Moreover, it causes zoonotic infections, producing pulmonary dirofilariasis in humans. Heartworm disease is a vector-borne transmitted disease, thus transmission depends on the presence of competent mosquito species, which is directly related to favorable climate conditions for its development and survival. Cardiopulmonary dirofilariasis is mainly located in countries with temperate and tropical climates. Europe is one of the continents where animal dirofilariasis has been studied more extensively. In this article we review the current prevalence of canine and feline cardiopulmonary dirofilariasis in the European continent, the transmission vectors, the current changes in the distribution and the possible causes, though the analysis of the epidemiological studies carried out until 2001 and between 2002-2011. The highest prevalences have been observed in the southern European countries, which are considered historically endemic/hyperendemic countries. Studies carried out in the last 10 years suggest an expansion of cardiopulmonary dirofilariasis in dogs towards central and northern Europe. Several factors can exert an influence on the spreading of the disease, such as movement of infected animals, the introduction of new species of mosquitoes able to act as vectors, the climate change caused by the global warming, and development of human activity in new areas. Veterinary controls to prevent the spreading of this disease, programs of control of vectors, and adequate protocols of prevention of dirofilariasis in the susceptible species should be carried out.

Vides de Simón de Rojas Clemente (1777-1827 en el herbario del Real Colegio Alfonso XII de San Lorenzo de El Escorial (Madrid, España

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Perea, Domingo

1997-12-01

Full Text Available In the present paper, the discovery of grape-vine mounted sheets from the Simón de Rojas Clemente herbarium, which were found in the Herbarium of the Real Colegio Alfonso XH in San Lorenzo de El Escorial, is reported. This material completes the collection of Clemente's vines which makes up one of the historical collections deposited in the MA herbarium.Damos a conocer unos pliegos de vides procedentes del herbario de Simón de Rojas Clemente que han aparecido en el Gabinete de Ciencias Naturales del Real Colegio Alfonso XII de San Lorenzo de El Escorial. Estos materiales completan la colección de vides de Clemente que constituye uno de los herbarios históricos depositados en MA.

Gramíneas uruguayas de D. José Arechavaleta (1838-1912, en el Real Colegio Alfonso XII de San Lorenzo de El Escorial (Madrid, España

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Carrasco, María A.

2001-12-01

Full Text Available The Royal Monastery of El Escorial was built in the xvi century by king Felipe U. In the part intended to be a college and seminary, the Real Colegio Alfonso XII was established in 1885. In this place, the treasures that had been accumulated for fíve hundred years, that carne from acquisitions, collections and donations, are stored. In this paper we present a small collection, of undeniable historical valué. It contains 186 Gramineae that were sent as a present to María Cristina, the Regent Queen of Spain, by the President of Uruguay on the occasion of the World Exhibition of Barcelona in 1888. The plants are part of the herbarium of the Flora Uruguaya of José Arechavaleta y Balparda [Santurce (España, 1838-Montevideo (Uruguay, 1912]. Some of the plants are annotated by Arechavaleta as new species, and some belong from the loc. clas. All this material is identified by Arechavaleta and J. Hackel.El Real Monasterio de El Escorial fue fundado en el siglo XVI por el rey Felipe n. En la parte dedicada a colegio-seminario se estableció en 1885 el Real Colegio Alfonso XII, donde están depositados todos los fondos que se han ido acumulando a lo largo de quinientos años, procedentes de adquisiciones, recolecciones y donaciones. En este trabajo presentamos una colección, pequeña pero de indudable valor histórico, de 186 Gramineae que fueron enviadas por el presidente del Uruguay a la reina regente de España con motivo de la Exposición Universal de Barcelona celebrada en 1888. Estos materiales son parte del herbario de la Flora Uruguaya de D. José Arechavaleta y Balparda [Santurce (España, 1838-Montevideo (Uruguay, 1912]. Algunas plantas están anotadas por Arechavaleta como especies nuevas -unas cuantas proceden de la localidad clásica- y todas ellas están identificadas por Arechavaleta o J. Hackel.

Climate Change and Spatiotemporal Distributions of Vector-Borne Diseases in Nepal--A Systematic Synthesis of Literature.

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Meghnath Dhimal

Full Text Available Despite its largely mountainous terrain for which this Himalayan country is a popular tourist destination, Nepal is now endemic for five major vector-borne diseases (VBDs, namely malaria, lymphatic filariasis, Japanese encephalitis, visceral leishmaniasis and dengue fever. There is increasing evidence about the impacts of climate change on VBDs especially in tropical highlands and temperate regions. Our aim is to explore whether the observed spatiotemporal distributions of VBDs in Nepal can be related to climate change.A systematic literature search was performed and summarized information on climate change and the spatiotemporal distribution of VBDs in Nepal from the published literature until December 2014 following providing items for systematic review and meta-analysis (PRISMA guidelines.We found 12 studies that analysed the trend of climatic data and are relevant for the study of VBDs, 38 studies that dealt with the spatial and temporal distribution of disease vectors and disease transmission. Among 38 studies, only eight studies assessed the association of VBDs with climatic variables. Our review highlights a pronounced warming in the mountains and an expansion of autochthonous cases of VBDs to non-endemic areas including mountain regions (i.e., at least 2,000 m above sea level. Furthermore, significant relationships between climatic variables and VBDs and their vectors are found in short-term studies.Taking into account the weak health care systems and difficult geographic terrain of Nepal, increasing trade and movements of people, a lack of vector control interventions, observed relationships between climatic variables and VBDs and their vectors and the establishment of relevant disease vectors already at least 2,000 m above sea level, we conclude that climate change can intensify the risk of VBD epidemics in the mountain regions of Nepal if other non-climatic drivers of VBDs remain constant.

β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint

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De Sanctis, Vincenzo; Kattamis, Christos; Canatan, Duran; Soliman, Ashraf T.; Elsedfy, Heba; Karimi, Mehran; Daar, Shahina; Wali, Yasser; Yassin, Mohamed; Soliman, Nada; Sobti, Praveen; Al Jaouni, Soad; El Kholy, Mohamed; Fiscina, Bernadette; Angastiniotis, Michael

2017-01-01

Background Haemoglobinopathies constitute the commonest recessive monogenic disorders worldwide, and the treatment of affected individuals presents a substantial global disease burden. β-thalassaemia is characterised by the reduced synthesis (β+) or absence (βo) of the β-globin chains in the HbA molecule, resulting in accumulation of excess unbound α-globin chains that precipitate in erythroid precursors in the bone marrow and in the mature erythrocytes, leading to ineffective erythropoiesis and peripheral haemolysis. Approximately 1.5% of the global population are heterozygotes (carriers) of the β-thalassemias; there is a high incidence in populations from the Mediterranean basin, throughout the Middle East, the Indian subcontinent, Southeast Asia, and Melanesia to the Pacific Islands. Aim The principal aim of this paper is to review, from a historical standpoint, our knowledge about an ancient disease, the β-thalassemias, and in particular, when, how and in what way β-thalassemia spread worldwide to reach such high incidences in certain populations. Results Mutations involving the β-globin gene are the most common cause of genetic disorders in humans. To date, more than 350 β-thalassaemia mutations have been reported. Considering the current distribution of β- thalassemia, the wide diversity of mutations and the small number of specific mutations in individual populations, it seems unlikely that β-thalassemia originated in a single place and time. Conclusions Various processes are known to determine the frequency of genetic disease in human populations. However, it is almost impossible to decide to what extent each process is responsible for the presence of a particular genetic disease. The wide spectrum of β-thalassemia mutations could well be explained by looking at their geographical distribution, the history of malaria, wars, invasions, mass migrations, consanguinity, and settlements. An analysis of the distribution of the molecular spectrum of

Epidemiological distribution of rodents as potent reservoirs for infectious diseases in the provinces of Mazandaran, Gilan and Golestan, northern Iran

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Behzad Esfandiari

2017-05-01

Full Text Available Rodents are mammals that comprise more than 2000 species and approximately 30 families. There are many morphological and ecological differences among them as variations in their shape, size, weight and habitat. In addition to significant economic losses, rodents have a major role in the dissemination of infectious diseases caused by viruses, bacteria, parasites or other micro-organisms. Rodents are important reservoirs of diseases which have been observed in many cities of Iran provinces especially along Caspian Sea border to Alborz Mountain. The aim of this study is to assess the geographical distribution of rodents in three provinces of northern part of Iran as reservoir of potential endemic infectious diseases. Rodents in 10 major parts of each of the three provinces of Mazandaran, Gilan and Golestan, northern Iran were collected and a total of 404 rodents were trapped alive. They were determined by the key characteristics such as gender, genus, species, different locations and topological situation. Statistical analysis was performed to characterize the study sample and to correlate all variables and parameters. The distribution frequencies of three, five and six genera of rodents were identified in Mazandaran, Gilan and Golestan provinces respectively. The overall distribution frequency of eight genera of rodents in the three provinces were identified as Rattus (R. norvegicus (67.3%, R. rattus (13.6%, Apodemus sylvaticus (13.9%, Arvicola (1%, Mus musculus (0.3%, Nesokia indica (2.5%, Cricetulus migrates (0.7% and Rhombomys opimus (0.7%. The results of this study determined the geographic distribution of the rodents in the three northern provinces of Iran. It is indicated the association of various distribution and diversity of rodents with provincial location. The overall distribution frequency of eight genera of rodents was recognized in the above three provinces geographical locations. This study confirms epidemiological distribution of

Dry eye disease: prevalence, distribution and determinants in a hospital-based population.

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Onwubiko, Stella N; Eze, Boniface I; Udeh, Nnemma N; Arinze, Obinna C; Onwasigwe, Ernest N; Umeh, Rich E

2014-06-01

To determine the prevalence, distribution and risk factors for dry eye disease (DED) in a tertiary ophthalmic outpatient population. The study was a cross-sectional descriptive hospital-based survey conducted at the Eye clinic of the University of Nigeria Teaching Hospital (UNTH), Enugu, between September and December, 2011. The participants comprised adult ophthalmic outpatients aged 18 years or older. Participants' sociodemographic data were obtained. Dry eye disease was assessed subjectively with the Ocular Surface Disease Index (OSDI) questionnaire; and objectively with Schirmer's test and Tear-film Break-up Time (TBUT). An OSDI score of ≥ 50 with a TBUT of 40 years (OR 1.88, 95% CI 1.06-3.35, p=0.0004), non-possession of formal education (OR 0.40, 95% CI 0.21-0.74, p=0.001) but not gender (OR 1.48, 95% CI 0.89-2.46, p=0.158). The prevalence of DED among ophthalmic outpatients at UNTH, Enugu, is comparatively high. Older age and illiteracy are predictors of DED. There is need for high index of diagnostic suspicion to prevent sight-threatening complications of DED. Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.

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Amanda R Lorier

2010-01-01

Full Text Available Hypoglossal (XII motoneurons innervate tongue muscles and are vital for maintaining upper-airway patency during inspiration. Depression of XII nerve activity by opioid analgesics is a significant clinical problem, but underlying mechanisms are poorly understood. Currently there are no suitable pharmacological approaches to counter opiate-induced suppression of XII nerve activity while maintaining analgesia. Ampakines accentuate alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA receptor responses. The AMPA family of glutamate receptors mediate excitatory transmission to XII motoneurons. Therefore the objectives were to determine whether the depressant actions of mu-opioid receptor activation on inspiratory activity includes a direct inhibitory action at the inspiratory premotoneuron to XII motoneuron synapse, and to identify underlying mechanism(s. We then examined whether ampakines counteract opioid-induced depression of XII motoneuron activity.A medullary slice preparation from neonatal rat that produces inspiratory-related output in vitro was used. Measurements of inspiratory burst amplitude and frequency were made from XII nerve roots. Whole-cell patch recordings from XII motoneurons were used to measure membrane currents and synaptic events. Application of the mu-opioid receptor agonist, DAMGO, to the XII nucleus depressed the output of inspiratory XII motoneurons via presynaptic inhibition of excitatory glutamatergic transmission. Ampakines (CX614 and CX717 alleviated DAMGO-induced depression of XII MN activity through postsynaptic actions on XII motoneurons.The inspiratory-depressant actions of opioid analgesics include presynaptic inhibition of XII motoneuron output. Ampakines counteract mu-opioid receptor-mediated depression of XII motoneuron inspiratory activity. These results suggest that ampakines may be beneficial in countering opiate-induced suppression of XII motoneuron activity and resultant impairment of airway patency.

Detrimental and protective fat: body fat distribution and its relation to metabolic disease.

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Booth, Andrea; Magnuson, Aaron; Foster, Michelle

2014-01-01

Obesity is linked to numerous comorbidities that include, but are not limited to, glucose intolerance, insulin resistance, dyslipidemia, and cardiovascular disease. Current evidence suggests, however, obesity itself is not an exclusive predictor of metabolic dysregulation but rather adipose tissue distribution. Obesity-related adverse health consequences occur predominately in individuals with upper body fat accumulation, the detrimental distribution, commonly associated with visceral obesity. Increased lower body subcutaneous adipose tissue, however, is associated with a reduced risk of obesity-induced metabolic dysregulation and even enhanced insulin sensitivity, thus, storage in this region is considered protective. The proposed mechanisms that causally relate the differential outcomes of adipose tissue distribution are often attributed to location and/or adipocyte regulation. Visceral adipose tissue effluent to the portal vein drains into the liver where hepatocytes are directly exposed to its metabolites and secretory products, whereas the subcutaneous adipose tissue drains systemically. Adipose depots are also inherently different in numerous ways such as adipokine release, immunity response and regulation, lipid turnover, rate of cell growth and death, and response to stress and sex hormones. Proximal extrinsic factors also play a role in the differential drive between adipose tissue depots. This review focuses on the deleterious mechanisms postulated to drive the differential metabolic response between central and lower body adipose tissue distribution.

Pathogen infection distribution and drug resistance analysis of patients with severe liver disease

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Xi CHEN

2018-04-01

Full Text Available Objective　To explore the infection distribution and drug resistance of pathogens in patients with severe liver disease, and provide reference for clinical medication. Methods　Retrospective analysis of the microbiological specimens from patients with severe liver disease in Department of Infection of our hospital from August 2014 to November 2016 and the drug susceptibility testing were carried out by means of K-B disc diffusion method after bacterial culturing, and the distribution and drug resistance of pathogens were analyzed. Results　Totally 17 of 73 patients with severe liver disease developed hospital infection (23.3%. 104 strains of bacteria were isolated and 78 strains out of them were multidrug-resistant bacteria (75.0%. Among them, 28(26.9% strains were gram-positive coccus, mainly consisting of Staphylococcus aureus and Staphylococcus epidermidis, and 58(55.8% were gram-negative coccus, mainly composed of Escherichia coli, Klebsiella pneumonia and Acinetobacter baumannii, and 18(17.3% strains fungi. S.aureus and enterococci were resistant to penicillin, erythromycin and levofloxacin, the resistance rates were above 80.0%, but had low resistance rates to vancomycin, teicoplanin and tigecycline. The resistance rates of E.coli and K.pneumoniae to piperacillin, cefazolin and cefuroxime sodium were above 85.0%, but they had lower resistance rates to tigecycline and amikacin. Acinetobacter baumannii was 100% resistant to piperacillin and tazobactam, ceftazidime, imipenem and amikacin, but had low resistance to tigecycline and minocycline. Conclusions　Multi-drug resistant bacteria are the main bacterial pathogens in patients with severe liver disease and have a high resistance rate to commonly used antibiotics, empirical treatment in the population at high risk of multidrug-resistant bacteria infections requires the use of broad-spectrum or high-grade antibiotics (e.g. carbapenems or tigecycline and drugs against specific pathogenic

Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer's Disease Patients.

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Rüb, Udo; Stratmann, Katharina; Heinsen, Helmut; Del Turco, Domenico; Ghebremedhin, Estifanos; Seidel, Kay; den Dunnen, Wilfred; Korf, Horst-Werner

2016-01-01

In spite of considerable progress in neuropathological research on Alzheimer's disease (AD), knowledge regarding the exact pathoanatomical distribution of the tau cytoskeletal pathology in the thalamus of AD patients in the advanced Braak and Braak AD stages V or VI of the cortical cytoskeletal pathology is still fragmentary. Investigation of serial 100 μm-thick brain tissue sections through the thalamus of clinically diagnosed AD patients with Braak and Braak AD stage V or VI cytoskeletal pathologies immunostained with the anti-tau AT8 antibody, along with the affection of the extraterritorial reticular nucleus of the thalamus, reveals a consistent and severe tau immunoreactive cytoskeletal pathology in the limbic nuclei of the thalamus (e.g., paraventricular, anterodorsal and laterodorsal nuclei, limitans-suprageniculate complex). The thalamic nuclei integrated into the associative networks of the human brain (e.g., ventral anterior and mediodorsal nuclei) are only mildly affected, while its motor precerebellar (ventral lateral nucleus) and sensory nuclei (e.g., lateral and medial geniculate bodies, ventral posterior medial and lateral nuclei, parvocellular part of the ventral posterior medial nucleus) are more or less spared. The highly stereotypical and characteristic thalamic distribution pattern of the AD-related tau cytoskeletal pathology represents an anatomical mirror of the hierarchical topographic distribution of the cytoskeletal pathology in the interconnected regions of the cerebral cortex of AD patients. These pathoanatomical parallels support the pathophysiological concept of a transneuronal spread of the disease process of AD along anatomical pathways. The AD-related tau cytoskeletal pathology in the thalamus most likely contributes substantially to the neuropsychiatric disease symptoms (e.g., dementia), attention deficits, oculomotor dysfunctions, altered non-discriminative aspects of pain experience of AD patients, and the disruption of their

Spatio-Temporal Distribution and Hotspots of Hand, Foot and Mouth Disease (HFMD in Northern Thailand

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Ratchaphon Samphutthanon

2013-12-01

Full Text Available Hand, Foot and Mouth Disease (HFMD is an emerging viral disease, and at present, there are no antiviral drugs or vaccines available to control it. Outbreaks have persisted for the past 10 years, particularly in northern Thailand. This study aimed to elucidate the phenomenon of HFMD outbreaks from 2003 to 2012 using general statistics and spatial-temporal analysis employing a GIS-based method. The spatial analysis examined data at the village level to create a map representing the distribution pattern, mean center, standard deviation ellipse and hotspots for each outbreak. A temporal analysis was used to analyze the correlation between monthly case data and meteorological factors. The results indicate that the disease can occur at any time of the year, but appears to peak in the rainy and cold seasons. The distribution of outbreaks exhibited a clustered pattern. Most mean centers and standard deviation ellipses occurred in similar areas. The linear directional mean values of the outbreaks were oriented toward the south. When separated by season, it was found that there was a significant correlation with the direction of the southwest monsoon at the same time. An autocorrelation analysis revealed that hotspots tended to increase even when patient cases subsided. In particular, a new hotspot was found in the recent year in Mae Hong Son province.

L'autografia d'autore Cambiamenti nella realizzazione e nella concezione del libro dal XII secolo all'invenzione della stampa

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Micol Long

2012-06-01

Full Text Available Si ritiene a volte che l'invenzione della stampa abbia innescato il cambiamento nel modo di concepire l'oggetto libro, segnando il passaggio dall'idea medievale a quella moderna. Occorre però tenere presente che esiste un'importante evoluzione interna al medioevo e che l'invenzione della stampa, per quanto fondamentale, è da inserire all'interno di questo processo più ampio, che a partire dal XII secolo circa trasforma l'uso e la funzione stessa della scrittura, rivoluziona il modo di leggere e di conseguenza il libro stesso, sia concettualmente sia come oggetto fisico. L'approccio scelto per questo studio mira a risalire alle radici culturali dei cambiamenti nelle pratiche del lavoro intellettuale e, viceversa, a indagare se e come tali cambiamenti abbiano potuto influenzare, attraverso le opere stesse, la cultura dell'epoca. Il fenomeno oggetto specifico dell'indagine è l'autografia letteraria d'autore che, eccezionale nell'alto medioevo, è testimoniata da una nuova e ininterrotta serie di casi a partire dall'XI-XII secolo, per poi diffondersi nei secoli successivi. Il panorama culturale della fine del medioevo appare dunque caratterizzato dalla tensione tra una ricorrente aspirazione all'individualizzazione del rapporto tra l'autore e il suo testo, che si realizzava in un modello di produzione libraria basato su uno stretto controllo dell'autore sul prodotto finale, dal punto di vista sia filologico-testuale sia grafico e materiale, e l'opposta tendenza all'allentamento del controllo dell'autore sulla propria opera, come naturale conseguenza di una sempre più vasta circolazione dei testi ma anche di una diversa concezione del ruolo autoriale. It is generally believed that the invention of printing triggered a cultural change, marking the passage between the medieval idea of the book and the modern one. It should be noted, though, that there was an important evolution through the Late Middle Ages, and that the printing revolution

Potential distribution of pine wilt disease under future climate change scenarios.

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Akiko Hirata

Full Text Available Pine wilt disease (PWD constitutes a serious threat to pine forests. Since development depends on temperature and drought, there is a concern that future climate change could lead to the spread of PWD infections. We evaluated the risk of PWD in 21 susceptible Pinus species on a global scale. The MB index, which represents the sum of the difference between the mean monthly temperature and 15 when the mean monthly temperatures exceeds 15°C, was used to determine current and future regions vulnerable to PWD (MB ≥ 22. For future climate conditions, we compared the difference in PWD risks among four different representative concentration pathways (RCPs 2.6, 4.5, 6.0, and 8.5 and two time periods (2050s and 2070s. We also evaluated the impact of climate change on habitat suitability for each Pinus species using species distribution models. The findings were then integrated and the potential risk of PWD spread under climate change was discussed. Within the natural Pinus distribution area, southern parts of North America, Europe, and Asia were categorized as vulnerable regions (MB ≥ 22; 16% of the total Pinus distribution area. Representative provinces in which PWD has been reported at least once overlapped with the vulnerable regions. All RCP scenarios showed expansion of vulnerable regions in northern parts of Europe, Asia, and North America under future climate conditions. By the 2070s, under RCP 8.5, an estimated increase in the area of vulnerable regions to approximately 50% of the total Pinus distribution area was revealed. In addition, the habitat conditions of a large portion of the Pinus distribution areas in Europe and Asia were deemed unsuitable by the 2070s under RCP 8.5. Approximately 40% of these regions overlapped with regions deemed vulnerable to PWD, suggesting that Pinus forests in these areas are at risk of serious damage due to habitat shifts and spread of PWD.

Unbiased Stereologic Estimation of the Spatial Distribution of Paget’s Disease in the Human Temporal Bone

DEFF Research Database (Denmark)

Bloch, Sune Land; Sørensen, Mads Sølvsten

2014-01-01

remodeling around the inner ear space and to compare it with that of otosclerosis in a contemporary context of temporal bone dynamics. MATERIALS AND METHODS: From the temporal bone collection of Massachusetts Eye and Ear Infirmary, 15 of 29 temporal bones with Paget's disease were selected to obtain...... an independent sample. All volume distributions were obtained along the normal axis of capsular bone remodeling activity by the use of vector-based stereology. RESULTS: Pagetic bone remodeling was distributed centrifugally around the inner ear space at the individual and the general level. This pattern...

PENERAPAN MODEL PEMBELAJARAN THINK PAIR SHARE DENGAN PENDEKATAN INKUIRI UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR IPA PADA SISWA KELAS XII SMK

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Beny Yulianingsih

2017-01-01

Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar siswa yang menggunakan model pembelajaran Think Pair Share (TPS dengan pendekatan inkuiri. Penelitian ini termasuk penelitian tindakan kelas yang dilaksanakan dalam dua siklus. Subjek penelitian adalah siswa kelas XII SMK NU Tenggarang Bondowoso tahun ajaran 2016/2017. Data penelitian diperoleh melalui observasi dan tes. Hasil penelitian menunjukkan terjadi peningkatan motivasi siswa dari siklus I ke siklus II sebesar 69,69% dengan rincian pada aspek attention sebesar 73,16% pada siklus I menjadi 92,53% pada siklus II, pada aspek relevance sebesar 79,20% pada siklus I menjadi 95,07% pada siklus II, pada aspek confidence sebesar 73,70% pada siklus I menjadi 89,40% pada siklus II, dan pada aspek satisfaction sebesar 72,69% pada siklus I menjadi 91,43% pada siklus II. Begitupula hasil belajar afektif yang diperoleh selama proses pembelajaran berlangsung juga mengalami peningkatan persentase yaitu 76,22% pada siklus I dan 83,67% pada siklus II. Untuk keterlaksanaan proses pembelajaran juga menunjukkan peningkatan dari 92,22% pada siklus 1 dan 95,66% pada siklus II. Dengan demikian, hasil ini menunjukkan bahwa model pembelajaran kooperatif TPS dengan pendekatan inkuiri dapat meningkatkan motivasi dan hasil belajar siswa.

Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.

Science.gov (United States)

Long, Ji-Rong; Zhao, Lan-Juan; Liu, Peng-Yuan; Lu, Yan; Dvornyk, Volodymyr; Shen, Hui; Liu, Yong-Jun; Zhang, Yuan-Yuan; Xiong, Dong-Hai; Xiao, Peng; Deng, Hong-Wen

2004-05-24

The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers. We examined the patterns of LD and haplotype distribution in eight candidate genes for osteoporosis and/or obesity using 31 SNPs in 1,873 subjects. These eight genes are apolipoprotein E (APOE), type I collagen alpha1 (COL1A1), estrogen receptor-alpha (ER-alpha), leptin receptor (LEPR), parathyroid hormone (PTH)/PTH-related peptide receptor type 1 (PTHR1), transforming growth factor-beta1 (TGF-beta1), uncoupling protein 3 (UCP3), and vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR). Yin yang haplotypes, two high-frequency haplotypes composed of completely mismatching SNP alleles, were examined. To quantify LD patterns, two common measures of LD, D' and r2, were calculated for the SNPs within the genes. The haplotype distribution varied in the different genes. Yin yang haplotypes were observed only in PTHR1 and UCP3. D' ranged from 0.020 to 1.000 with the average of 0.475, whereas the average r2 was 0.158 (ranging from 0.000 to 0.883). A decay of LD was observed as the intermarker distance increased, however, there was a great difference in LD characteristics of different genes or even in different regions within gene. The differences in haplotype distributions and LD patterns among the genes underscore the importance of characterizing genomic regions of interest prior to association studies.

PENGARUH BIMBINGAN KARIR DAN LINGKUNGAN SEKOLAH MELALUI MOTIVASI KERJA TERHADAP KESIAPAN KERJA SISWA KELAS XII KOMPETENSI KEAHLIAN AKUNTANSI SMK NEGERI 2 MAGELANG

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Muhammad Zachim Alfan

2013-02-01

Full Text Available Kesiapan kerja merupakan keseluruhan kondisi individu yang meliputi kematangan fisik, mental dan pengalaman serta adanya kemauan dan kemampuan untuk melaksanakan suatu pekerjaan atau kegiatan. Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya pengaruh bimbingan karir dan lingkungan sekolah melalui motivasi terhadap kesiapan kerja siswa kelas XII SMK Negeri 2 Magelang. Populasi penelitian ini adalah siswa kelas XII Kompetensi Keahlian Akuntansi SMK Negeri 2 Magelang Tahun Ajaran 2013/2014. Jumlah sampel sebanyak 84 siswa yang diambil dengan menggunakan rumus Isaac. Pengambilan sampel tiap kelas menggunakan proporsional random sampling. Metode pengumpulan data adalah angket. Metode analisis data menggunakan teknik analisis deskriptif, regresi linear berganda dan analisis jalur. Hasil penelitian menunjukkan bahwa terdapat pengaruh bimbingan karir terhadap kesiapan kerja siswa (48,1%, lingkungan sekolah berpengaruh terhadap kesiapan kerja siswa (33,5%, bimbingan karir berpengaruh terhadap motivasi kerja siswa (30,5%, ada pengaruh lingkungan sekolah terhadap motivasi kerja siswa (27%, bimbingan karir melalui motivasi kerja berpengaruh terhadap kesiapan kerja siswa (50,8%, dan lingkungan sekolah melalui motivasi kerja berpengaruh terhadap kesiapan kerja siswa (35,9%. The working readiness is the entire condition of an individual including physical maturity, mental maturity, experiential maturity, the existence of willingness and capability to do a job or activity. The purpose of this study is to know whether there is influence of career guidance and environmental school through motivation toward the working readiness of the twelfth graders who are taking accountancy program at State Vocational High School 2 Magelang. In this research, the population was the twelfth graders with year of education 2013/2014 who are taking accountancy program at State Vocational High School 2 Magelang. The population was the twelfth graders with year of

ESTUDIOS METODOLÓGICOS DEL EFECTO DEL REGADÍO SOBRE LA CALIDAD DE LAS AGUAS DE LAS MASAS ASOCIADAS A UNA ZONA REGABLE: EL CASO DEL SECTOR B-XII DE LA ZONA REGABLE DEL BAJO GADALQUIVIR

OpenAIRE

Martínez Beltrán, J.

2015-01-01

[ES] El objeto del estudio ha sido determinar los efectos de la agricultura de regadío del Sector B-XII en la detracción de agua del Guadalquivir y en los contenidos de sales y nitratos de sus aguas en el tramo asociado a este sector, así como en el agua subterránea subyacente. La dotación de agua asignada en la campaña 2012-2013 ha sido inferior a la calculada para satisfacer las necesidades de agua de riego de los cultivos y el control de la salinidad de los suelos. La detrac...

Validation of a Leadership Scale in the Classrooms in an Indonesian University

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Laurens Kaluge

2016-02-01

Full Text Available This article examines the Leader Behaviour Description Questionnaire Form XII (LBDQ XII to determine whether it is applicable in Indonesia for teaching purposes. The instrument was translated into Indonesian with a slight modification in wording and distributed to the student teachers in State University of Surabaya. The sample, consisting of 300 subjects, was obtained by stratified random sampling from all of the faculties. By analysing the item characteristics (in terms of appropriateness, importance, and discriminating ability, confirmatory factor analysis, and calculating alpha and omega, the major results are: 59 items were considered applicable, 8 dimensions were confirmed by COSAN, and the sufficient high estimation of reliability

Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients

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Hanae Takatsuki, PhD

2016-10-01

Full Text Available Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity.

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

Directory of Open Access Journals (Sweden)

Peter A. Bell

2013-06-01

Pseudoachondroplasia and multiple epiphyseal dysplasia are genetic skeletal diseases resulting from mutations in cartilage structural proteins. Electron microscopy and immunohistochemistry previously showed that the appearance of the cartilage extracellular matrix (ECM in targeted mouse models of these diseases is disrupted; however, the precise changes in ECM organization and the pathological consequences remain unknown. Our aim was to determine the effects of matrilin-3 and COMP mutations on the composition and extractability of ECM components to inform how these detrimental changes might influence cartilage organization and degeneration. Cartilage was sequentially extracted using increasing denaturants and the extraction profiles of specific proteins determined using SDS-PAGE/Western blotting. Furthermore, the relative composition of protein pools was determined using mass spectrometry for a non-biased semi-quantitative analysis. Western blotting revealed changes in the extraction of matrilins, COMP and collagen IX in mutant cartilage. Mass spectrometry confirmed quantitative changes in the extraction of structural and non-structural ECM proteins, including proteins with roles in cellular processes such as protein folding and trafficking. In particular, genotype-specific differences in the extraction of collagens XII and XIV and tenascins C and X were identified; interestingly, increased expression of several of these genes has recently been implicated in susceptibility and/or progression of murine osteoarthritis. We demonstrated that mutation of matrilin-3 and COMP caused changes in the extractability of other cartilage proteins and that proteomic analyses of Matn3 V194D, Comp T585M and Comp DelD469 mouse models revealed both common and discrete disease signatures that provide novel insight into skeletal disease mechanisms and cartilage degradation.

DEPENDENT UPON ENVIRONMENTAL CONDITIONS FEATURES AND DISTRIBUTION DYNAMICS OF CHILDREN'S HEART DISEASE IN THE REPUBLIC OF DAGESTAN

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G. M. Abdurakhmanov

2014-01-01

Full Text Available Based on the analysis of statistical data on child morbidity (from 0 to 17 years old of the Republic of Dagestan the structure, dynamics and distribution features of cardiovascular diseases, chronic rheumatism, hypertension, congenital heart disease in 2009–2011 are examined. High rates of cardiac morbidity among residents of areas with unfavorable ecological environment characterized by a high content of pollutants in the composition of drinking water, soil and pasture vegetation are mentioned.

Experimental study of the large-scale axially heterogeneous liquid-metal fast breeder reactor at the fast critical assembly: Power distribution measurements and their analyses

International Nuclear Information System (INIS)

Iijima, S.; Obu, M.; Hayase, T.; Ohno, A.; Nemoto, T.; Okajima, S.

1988-01-01

Power distributions of the large-scale axially heterogeneous liquid-metal fast breeder reactor were studied by using the experiment results of fast critical assemblies XI, XII, and XIII and the results of their analyses. The power distributions were examined by the gamma-scanning method and fission rate measurements using /sup 239/Pu and /sup 238/U fission counters and the foil irradiation method. In addition to the measurements in the reference core, the power distributions were measured in the core with a control rod inserted and in a modified core where the shape of the internal blanket was determined by the radial boundary. The calculation was made by using JENDL-2 and the Japan Atomic Energy Research Institute's standard calculation system for fast reactor neutronics. The power flattening trend, caused by the decrease of the fast neutron flux, was observed in the axial and radial power distributions. The effect of the radial boundary shape of the internal blanket on the power distribution was determined in the core. The thickness of the internal blanket was reduced at its radial boundary. The influence of the internal blanket was observed in the power distributions in the core with a control rod inserted. The calculation predicted the neutron spectrum harder in the internal blanket. In the radial distributions of /sup 239/Pu fission rates, the space dependency of the calculated-to-experiment values was found at the active core close to the internal blanket

Circulating TFH subset distribution is strongly affected in lupus patients with an active disease.

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Carole Le Coz

Full Text Available Follicular helper T cells (TFH represent a distinct subset of CD4(+ T cells specialized in providing help to B lymphocytes, which may play a central role in autoimmune diseases having a major B cell component such as systemic lupus erythematosus. Recently, TFH subsets that share common phenotypic and functional characteristics with TFH cells from germinal centers, have been described in the peripheral blood from healthy individuals. The aim of this study was to analyze the distribution of such populations in lupus patients. Circulating TFH cell subsets were defined by multicolor flow cytometry as TFH17 (CXCR3(-CCR6(+, TFH1 (CXCR3 (+ CCR6(- or TFH2 (CXCR3(-CCR6(- cells among CXCR5 (+ CD45RA(-CD4(+ T cells in the peripheral blood of 23 SLE patients and 23 sex and age-matched healthy controls. IL-21 receptor expression by B cells was analyzed by flow cytometry and the serum levels of IL-21 and Igs were determined by ELISA tests. We found that the TFH2 cell subset frequency is strongly and significantly increased in lupus patients with an active disease (SLEDAI score>8, while the TFH1 cell subset percentage is greatly decreased. The TFH2 and TFH1 cell subset frequency alteration is associated with the presence of high Ig levels and autoantibodies in patient's sera. Moreover, the TFH2 cell subset enhancement correlates with an increased frequency of double negative memory B cells (CD27(-IgD(-CD19(+ cells expressing the IL-21R. Finally, we found that IgE levels in lupus patients' sera correlate with disease activity and seem to be associated with high TFH2 cell subset frequency. In conclusion, our study describes for the first time the distribution of circulating TFH cell subsets in lupus patients. Interestingly, we found an increased frequency of TFH2 cells, which correlates with disease activity. Our results suggest that this subset might play a key role in lupus pathogenesis.

Angiostrongylus spp. in the Americas: geographical and chronological distribution of definitive hosts versus disease reports.

Science.gov (United States)

Valente, Romina; Robles, Maria Del Rosario; Navone, Graciela T; Diaz, Julia I

2018-03-01

Angiostrongyliasis is an infection caused by nematode worms of the genus Angiostrongylus. The adult worms inhabit the pulmonary arteries, heart, bronchioles of the lung, or mesenteric arteries of the caecum of definitive host. Of a total of 23 species of Angiostrongylus cited worldwide, only nine were registered in the American Continent. Two species, A. cantonensis and A. costaricensis, are considered zoonoses when the larvae accidentally parasitise man. In the present study, geographical and chronological distribution of definitive hosts of Angiostrongylus in the Americas is analysed in order to observe their relationship with disease reports. Moreover, the role of different definitive hosts as sentinels and dispersers of infective stages is discussed. The study area includes the Americas. First records of Angiostrongylus spp. in definitive or accidental hosts were compiled from the literature. Data were included in tables and figures and were matched to geographic information systems (GIS). Most geographical records of Angiostrongylus spp. both for definitive and accidental hosts belong to tropical areas, mainly equatorial zone. In relation to those species of human health importance, as A. cantonensis and A. costaricensis, most disease cases indicate a coincidence between the finding of definitive host and disease record. However, in some geographic site there are gaps between report of definitive host and disease record. In many areas, human populations have invaded natural environments and their socioeconomic conditions do not allow adequate medical care. Consequently, many cases for angiostrongyliasis could have gone unreported or unrecognised throughout history and in the nowadays. Moreover, the population expansion and the climatic changes invite to make broader and more complete range of observation on the species that involve possible epidemiological risks. This paper integrates and shows the current distribution of Angiostrongylus species in America

Angiostrongylus spp. in the Americas: geographical and chronological distribution of definitive hosts versus disease reports

Science.gov (United States)

Valente, Romina; Robles, Maria del Rosario; Navone, Graciela T; Diaz, Julia I

2018-01-01

BACKGROUND Angiostrongyliasis is an infection caused by nematode worms of the genus Angiostrongylus. The adult worms inhabit the pulmonary arteries, heart, bronchioles of the lung, or mesenteric arteries of the caecum of definitive host. Of a total of 23 species of Angiostrongylus cited worldwide, only nine were registered in the American Continent. Two species, A. cantonensis and A. costaricensis, are considered zoonoses when the larvae accidentally parasitise man. OBJECTIVES In the present study, geographical and chronological distribution of definitive hosts of Angiostrongylus in the Americas is analysed in order to observe their relationship with disease reports. Moreover, the role of different definitive hosts as sentinels and dispersers of infective stages is discussed. METHODS The study area includes the Americas. First records of Angiostrongylus spp. in definitive or accidental hosts were compiled from the literature. Data were included in tables and figures and were matched to geographic information systems (GIS). FINDINGS Most geographical records of Angiostrongylus spp. both for definitive and accidental hosts belong to tropical areas, mainly equatorial zone. In relation to those species of human health importance, as A. cantonensis and A. costaricensis, most disease cases indicate a coincidence between the finding of definitive host and disease record. However, in some geographic site there are gaps between report of definitive host and disease record. In many areas, human populations have invaded natural environments and their socioeconomic conditions do not allow adequate medical care. MAIN CONCLUSIONS Consequently, many cases for angiostrongyliasis could have gone unreported or unrecognised throughout history and in the nowadays. Moreover, the population expansion and the climatic changes invite to make broader and more complete range of observation on the species that involve possible epidemiological risks. This paper integrates and shows the

Optimized oral cholera vaccine distribution strategies to minimize disease incidence: A mixed integer programming model and analysis of a Bangladesh scenario.

Science.gov (United States)

Smalley, Hannah K; Keskinocak, Pinar; Swann, Julie; Hinman, Alan

2015-11-17

In addition to improved sanitation, hygiene, and better access to safe water, oral cholera vaccines can help to control the spread of cholera in the short term. However, there is currently no systematic method for determining the best allocation of oral cholera vaccines to minimize disease incidence in a population where the disease is endemic and resources are limited. We present a mathematical model for optimally allocating vaccines in a region under varying levels of demographic and incidence data availability. The model addresses the questions of where, when, and how many doses of vaccines to send. Considering vaccine efficacies (which may vary based on age and the number of years since vaccination), we analyze distribution strategies which allocate vaccines over multiple years. Results indicate that, given appropriate surveillance data, targeting age groups and regions with the highest disease incidence should be the first priority, followed by other groups primarily in order of disease incidence, as this approach is the most life-saving and cost-effective. A lack of detailed incidence data results in distribution strategies which are not cost-effective and can lead to thousands more deaths from the disease. The mathematical model allows for what-if analysis for various vaccine distribution strategies by providing the ability to easily vary parameters such as numbers and sizes of regions and age groups, risk levels, vaccine price, vaccine efficacy, production capacity and budget. Copyright © 2015 Elsevier Ltd. All rights reserved.

10 CFR 51.22 - Criterion for categorical exclusion; identification of licensing and regulatory actions eligible...

Science.gov (United States)

2010-01-01

... requirements. (11) Issuance of amendments to licenses for fuel cycle plants and radioactive waste disposal.... (xii) Acceptance of packaged radioactive wastes from others for transfer to licensed land burial... the following types of activities: (i) Distribution of radioactive material and devices or products...

Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.

Science.gov (United States)

Takatsuki, Hanae; Fuse, Takayuki; Nakagaki, Takehiro; Mori, Tsuyoshi; Mihara, Ban; Takao, Masaki; Iwasaki, Yasushi; Yoshida, Mari; Murayama, Shigeo; Atarashi, Ryuichiro; Nishida, Noriyuki; Satoh, Katsuya

2016-10-01

Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 10 6 /g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 10 6 /g SD50 did not exist the infectivity. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Distribution of nontuberculous mycobacteria in treated patients with pulmonary disease in Greece - relation to microbiological data.

Science.gov (United States)

Manika, Katerina; Tsikrika, Stamatoula; Tsaroucha, Emilia; Karabela, Simona; Karachaliou, Iris; Bosmi, Ioulia; Kioumis, Ioannis; Papavasileiou, Apostolos

2015-01-01

The aim was to assess the distribution of nontuberculous mycobacteria (NTM) in treated patients with pulmonary disease (PD) in Greece. Patients treated for NTM PD at the two largest chest diseases hospitals in Greece, in the period 1990-2013 were investigated. For the years 2005-2013 data on NTM isolation frequency were recorded. M. avium complex (MAC) was the predominant cause of NTM PD disease followed by M. kansasii and rapid growing mycobacteria (RGM). The pathogenicity of RGM was significantly lower than this of MAC and M. kansasii. An increase was observed in the percentage of isolated NTM species that were considered clinically significant over the study period. The increasing number of NTM PD in Greece is a consequence of their isolation being more frequently considered as clinically relevant.

Biophysical, infrastructural and social heterogeneities explain spatial distribution of waterborne gastrointestinal disease burden in Mexico City

Science.gov (United States)

Baeza, Andrés; Estrada-Barón, Alejandra; Serrano-Candela, Fidel; Bojórquez, Luis A.; Eakin, Hallie; Escalante, Ana E.

2018-06-01

Due to unplanned growth, large extension and limited resources, most megacities in the developing world are vulnerable to hydrological hazards and infectious diseases caused by waterborne pathogens. Here we aim to elucidate the extent of the relation between the spatial heterogeneity of physical and socio-economic factors associated with hydrological hazards (flooding and scarcity) and the spatial distribution of gastrointestinal disease in Mexico City, a megacity with more than 8 million people. We applied spatial statistics and multivariate regression analyses to high resolution records of gastrointestinal diseases during two time frames (2007–2009 and 2010–2014). Results show a pattern of significant association between water flooding events and disease incidence in the city center (lowlands). We also found that in the periphery (highlands), higher incidence is generally associated with household infrastructure deficiency. Our findings suggest the need for integrated and spatially tailored interventions by public works and public health agencies, aimed to manage socio-hydrological vulnerability in Mexico City.

Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study

NARCIS (Netherlands)

Canoy, Dexter; Boekholdt, S. Matthijs; Wareham, Nicholas; Luben, Robert; Welch, Ailsa; Bingham, Sheila; Buchan, Iain; Day, Nicholas; Khaw, Kay-Tee

2007-01-01

Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain. We examined the prospective relation between fat distribution indices and coronary heart disease among 24,508 men and

Red Blood Cell Distribution Width: A Novel Predictive Indicator for Cardiovascular and Cerebrovascular Diseases

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Ning Li

2017-01-01

Full Text Available The red blood cell distribution width (RDW obtained from a standard complete blood count (CBC is a convenient and inexpensive biochemical parameter representing the variability in size of circulating erythrocytes. Over the past few decades, RDW with mean corpuscular volume (MCV has been used to identify quite a few hematological system diseases including iron-deficiency anemia and bone marrow dysfunction. In recent years, many clinical studies have proved that the alterations of RDW levels may be associated with the incidence and prognosis in many cardiovascular and cerebrovascular diseases (CVDs. Therefore, early detection and intervention in time of these vascular diseases is critical for delaying their progression. RDW as a new predictive marker and an independent risk factor plays a significant role in assessing the severity and progression of CVDs. However, the mechanisms of the association between RDW and the prognosis of CVDs remain unclear. In this review, we will provide an overview of the representative literatures concerning hypothetical and potential epidemiological associations between RDW and CVDs and discuss the underlying mechanisms.

Consilium y fortalecimiento regio: consejeros y acción política regia en el reino de León en los siglos XI y XII

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Fernando Luis Corral

2011-11-01

Full Text Available Este trabajo pretende ver la relación existente entre el acto de aconsejar y la realidad de la acción política regia en el reino leonés durante los siglos XI y XII. Como es sabido, el consejo formaba parte de los formulismos vasalláticos –consilium et auxilium– que definían la relación que se establecía entre la nobleza y la monarquía fundamentalmente a través de los juramentos de homenaje en los que la nobleza reconocía, al menos teóricamente, la superioridad del rey como su señor. El monarca, a su vez, por la fidelidad que los nobles le juraban controlaba sus movimientos aunque se veía obligado a recompensarles adecuadamente sus servicios para ganarse su apoyo. Pero a finales del siglo XII, estos formulismos vasalláticos de los que el consilium era un elemento importante se comenzaron a mostrar ineficaces para contrarrestar el poder político de la nobleza y sus movimientos cada vez más autónomos rompiendo su fidelitas con el rey. Paulatinamente la monarquía leonesa utilizó nuevas estrategias de control que, incorporando el Derecho Romano a sus formulaciones teóricas legales, la situó en una posición inmejorable para introducir elementos nuevos de organización y administración del territorio, como los tenentes y merinos regios. Éstas y otras actuaciones fueron determinantes en el fortalecimiento regio que experimentaron los monarcas leoneses durante el siglo XII.Ce travail porte sur le rapport entre l'acte de conseiller et la réalité de l'action politique royale dans le royaume de León au cours des XIe et XIIe siècles. Le conseil apparaît dans les formules qui, comme “consilium et auxilium”, définissent la relation entre la noblesse et la monarchie, essentiellement dans les serments accompagnant l'hommage vassalique et par lesquels la noblesse reconnaissait, du moins théoriquement, la supériorité du roi en tant que seigneur. Grâce à la fidélité que les nobles lui juraient, le monarque exer

Spatial distribution of dengue disease in municipality of Mossoró, Rio Grande do Norte, using the Geographic Information System

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Francisco Narcísio Bessa Júnior

2013-09-01

Full Text Available The dengue viral infection is one of the most relevant vector-borne diseases in the world. The disease can manifest in a variety of forms, from asymptomatic to a condition of dengue hemorrhagic fever (DHF. The last reported cases in Brazil correspond to 80% of the cases reported in the Americas, which emphasizes the magnitude of the problem. This study was conducted using Geographic Information System (GIS techniques, in order to evaluate the spatial distribution of the disease in the urban area of Mossoró, Rio Grande do Norte. In the period between 2001 and 2007, 867 new cases were listed. About 85.7% of the addresses were georeferenced, with a larger number of cases, 14.8%, in the neighborhoods of Santo Antônio and Santa Delmira (north region, and 11.7% in the neighborhoods of Conjunto Vingt-Rosado and Alto de São Manoel (east region. There were 18 confirmed cases of dengue hemorrhagic fever associated with regions with the highest incidence of classic cases of the disease. The use of Geographic Information System (GIS proved a great benefit for better visualization of the endemic, especially in elucidating the actual distribution of dengue cases in the county and providing an effective tool for planning the monitoring of the disease at a local level.

42 CFR 483.20 - Resident assessment.

Science.gov (United States)

2010-10-01

... structural problems. (ix) Continence. (x) Disease diagnoses and health conditions. (xi) Dental and nutritional status. (xii) Skin condition. (xiii) Activity pursuit. (xiv) Medications. (xv) Special treatments... absence for hospitalization or for therapeutic leave.) (ii) Within 14 calendar days after the facility...

Preliminary report on AED deployment on the entire Air France commercial fleet: a joint venture with Paris XII University Training Programme.

Science.gov (United States)

Bertrand, C; Rodriguez Redington, P; Lecarpentier, E; Bellaiche, G; Michel, D; Teiger, E; Morris, W; Le Bourgeois, J P; Barthout, M

2004-11-01

The positive effect of early defibrillation on survival from cardiac arrest has been demonstrated. We describe the use of AEDs over 1 year following the training of flight attendants. Air France and the University of Paris XII together designed a 1 year training programme for 14000 flight attendants. The university emergency departments (SAMU) provided 250 instructors. AEDs training and certification was conducted for crew members between November 2001 and November 2002. By January 2003, all aircraft were fully equipped with AEDs. All cases of cardiac arrest that occurred during the study were reviewed comprehensively. Comments from the crew were collected. Twelve cardiac arrests were reported between November 2002 and November 2003 out of 4194 cases of emergency care delivered to passengers. Shock treatment was advised initially in 5/12 cases. The survival rate after in-flight cardiac arrest was 3/12. The survival rate at discharge from hospital following in flight shock was 2/5. No complications arose from the use of AEDs. Training by professionals gave the flight attendants confidence and allowed for the survival of two young passengers. Our study highlights the ability of flight attendants to give better onboard care for the future. The next step is to consolidate the network between in-flight care and the medical dispatch centre in Paris.

Spatial distribution of an infectious disease in a small mammal community

Science.gov (United States)

Correa, Juana P.; Bacigalupo, Antonella; Fontúrbel, Francisco E.; Oda, Esteban; Cattan, Pedro E.; Solari, Aldo; Botto-Mahan, Carezza

2015-10-01

Chagas disease is a zoonosis caused by the parasite Trypanosoma cruzi and transmitted by insect vectors to several mammals, but little is known about its spatial epidemiology. We assessed the spatial distribution of T. cruzi infection in vectors and small mammals to test if mammal infection status is related to the proximity to vector colonies. During four consecutive years we captured and georeferenced the locations of mammal species and colonies of Mepraia spinolai, a restricted-movement vector. Infection status on mammals and vectors was evaluated by molecular techniques. To examine the effect of vector colonies on mammal infection status, we constructed an infection distance index using the distance between the location of each captured mammal to each vector colony and the average T. cruzi prevalence of each vector colony, weighted by the number of colonies assessed. We collected and evaluated T. cruzi infection in 944 mammals and 1976 M. spinolai. We found a significant effect of the infection distance index in explaining their infection status, when considering all mammal species together. By examining the most abundant species separately, we found this effect only for the diurnal and gregarious rodent Octodon degus. Spatially explicit models involving the prevalence and location of infected vectors and hosts had not been reported previously for a wild disease.

Mis tuleb

Index Scriptorium Estoniae

2004-01-01

Detsembris Mahtra talurahvamuuseumis Atla mõisa keraamika- ja taimeseaderingi Takjanupud jõuluseadete näitus. 4. XII Tallinnas Säästva Renoveerimise Infokeskuses naturaalkrohvi töötuba. Kuni 4. XII Rapla keskraamatukogus Saima Randjärve näitus "Valguses". 9., 11., 17. ja 18. XII Säästva Renoveerimise Keskuses Jüri Kuusmanni loodusvärvide kursus. 11. XII Türi kultuurimajas tekstiilist kuuskede konkurss "Kuusepuu 2004". 14. XII Eesti Rahva Muuseumis 9. koolidevaheline jõuluteemaline võistujoonistamine. Tartu Mämguasjamuuseumis on 15.-23. XII avatud jõuluhõnguline mängutuba ja näitus Heli Männi mänguasjade kogust

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Science.gov (United States)

Dimitrov, Kiril M.; Ramey, Andy M.; Qiu, Xueting; Bahl, Justin; Afonso, Claudio L.

2016-01-01

Newcastle disease is caused by virulent forms of avian paramyxovirus of serotype 1 (APMV-1) and has global economic importance. The disease reached panzootic proportions within two decades after first being identified in 1926 in the United Kingdom and Indonesia and still remains endemic in many countries across the world. Here we review information on the host, temporal, and geographic distribution of APMV-1 genetic diversity based on the evolutionary systematics of the complete coding region of the fusion gene. Strains of APMV-1 are phylogenetically separated into two classes (class I and class II) and further classified into genotypes based on genetic differences. Class I viruses are genetically less diverse, generally present in wild waterfowl, and are of low virulence. Class II viruses are genetically and phenotypically more diverse, frequently isolated from poultry with occasional spillovers into wild birds, and exhibit a wider range of virulence. Waterfowl, cormorants, and pigeons are natural reservoirs of all APMV-1 pathotypes, except viscerotropic velogenic viruses for which natural reservoirs have not been identified. Genotypes I and II within class II include isolates of high and low virulence, the latter often being used as vaccines. Viruses of genotypes III and IX that emerged decades ago are now isolated rarely, but may be found in domestic and wild birds in China. Containing only virulent viruses and responsible for the majority of recent outbreaks in poultry and wild birds, viruses from genotypes V, VI, and VII, are highly mobile and have been isolated on different continents. Conversely, virulent viruses of genotypes XI (Madagascar), XIII (mainly Southwest Asia), XVI (North America) and XIV, XVII and XVIII (Africa) appear to have a more limited geographic distribution and have been isolated predominantly from poultry.

Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities.

Science.gov (United States)

Whittington, Alex; Sharp, David J; Gunn, Roger N

2018-05-01

β-amyloid (Aβ) accumulation in the brain is 1 of 2 pathologic hallmarks of Alzheimer disease (AD), and the spatial distribution of Aβ has been studied extensively ex vivo. Methods: We applied mathematical modeling to Aβ in vivo PET imaging data to investigate competing theories of Aβ spread in AD. Results: Our results provided evidence that Aβ accumulation starts in all brain regions simultaneously and that its spatiotemporal distribution is due to heterogeneous regional carrying capacities (regional maximum possible concentration of Aβ) for the aggregated protein rather than to longer-term spreading from seed regions. Conclusion: The in vivo spatiotemporal distribution of Aβ in AD can be mathematically modeled using a logistic growth model in which the Aβ carrying capacity is heterogeneous across the brain but the exponential growth rate and time of half maximal Aβ concentration are constant. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

Using landscape epidemiological models to understand the distribution of chronic wasting disease in the Midwestern USA

Science.gov (United States)

Robinson, Stacie J.; Samuel, Michael D.; Rolley, Robert E.; Shelton, Paul

2013-01-01

Animal movement across the landscape plays a critical role in the ecology of infectious wildlife diseases. Dispersing animals can spread pathogens between infected areas and naïve populations. While tracking free-ranging animals over the geographic scales relevant to landscape-level disease management is challenging, landscape features that influence gene flow among wildlife populations may also influence the contact rates and disease spread between populations. We used spatial diffusion and barriers to white-tailed deer gene flow, identified through landscape genetics, to model the distribution of chronic wasting disease (CWD) in the infected region of southern Wisconsin and northern Illinois, USA. Our generalized linear model showed that risk of CWD infection declined exponentially with distance from current outbreaks, and inclusion of gene flow barriers dramatically improved fit and predictive power of the model. Our results indicate that CWD is spreading across the Midwestern landscape from these two endemic foci, but spread is strongly influenced by highways and rivers that also reduce deer gene flow. We used our model to plot a risk map, providing important information for CWD management by identifying likely routes of disease spread and providing a tool for prioritizing disease monitoring and containment efforts. The current analysis may serve as a framework for modeling future disease risk drawing on genetic information to investigate barriers to spread and extending management and monitoring beyond currently affected regions.

Esclavos musulmanes en los hospitales de cautivos de la Orden Militar de Santiago (siglos XII y XIII

Directory of Open Access Journals (Sweden)

Echevarría Arsuaga, Ana

2007-12-01

Full Text Available Military Orders had slave manpower in their lands since their foundation. However, the hospitals for ransoming captives owned by the Order of Santiago are the best example of how slavery worked in the kingdom of Leon-Castile during the twelfth and thirteenth centuries. These houses had enough room to provide lodging for captives while ransoms were being negotiated. They also helped to redistribute those Muslims who, lacking this possibility, became slaves of the order itself, or were sold in the slave markets of the kingdom. The scarce records kept in the Archivo Histórico Nacional, section Órdenes Militares, referring to slaves, help to understand the development of traffic, work and manumission of these people.

Las órdenes militares dispusieron desde su fundación de mano de obra esclava en sus tierras, pero la institución que mejor sirve para estudiar la esclavitud en los siglos XII y XIII en los reinos de León y Castilla son los hospitales para la redención de cautivos de la Orden de Santiago. Estas instituciones disponían de espacio para alojar a los cautivos mientras se negociaban rescates con los poderes islámicos, y atendían a la redistribución de aquellos musulmanes que, por no haber sido redimidos, pasaban a ser esclavos de la propia orden o a ser vendidos en los mercados de los reinos cristianos. Los escasos documentos de la sección de Órdenes Militares del Archivo Histórico Nacional dedicados a esclavos ayudan a comprender el funcionamiento del tráfico, trabajo y liberación de este colectivo.

Conceptual and methodological issues in the study of destructive periodontal diseases among the young

DEFF Research Database (Denmark)

Lopez, Rodrigo

2010-01-01

Oprindeligt var det ideen med de studier [I-XII], der ligger til grund for denne afhandling, at undersøge de epidemiologiske og kliniske karakteristika vedrørende sygdomsenheden 'Tidligt Indsættende Parodontitis', og at benytte et case-control design til at vurdere betydningen af en række mulige ...

Frequency distribution of gastro esophageal reflux disease in inhalation injury: A historical cohort study.

Science.gov (United States)

Karbasi, Ashraf; Aliannejad, Rasoul; Ghanei, Mostafa; Sanamy, Mehran Noory; Alaeddini, Farshid; Harandi, Ali Amini

2015-07-01

There is no data on the prevalence and the association of gastro esophageal reflux disease (GERD) with toxic fume inhalation. Therefore, we aimed to evaluate the frequency distribution of GERD symptoms among the individuals with mild respiratory disorder due to the past history of toxic fume exposure to sulfur mustard (SM). In a historical cohort study, subjects were randomly selected from 7000 patients in a database of all those who had a history of previous exposure to a single high dose of SM gas during war. The control group was randomly selected from adjacent neighbors of the patients, and two healthy male subjects were chosen per patient. In this study, we used the validated Persian translation of Mayo Gastroesophageal Reflux Questionnaire to assess the frequency distribution of reflux disease. Relative frequency of GERD symptoms, was found to be significantly higher in the inhalation injury patients with an odds ratio of 8.30 (95% confidence interval [CI]: 4.73-14.55), and after adjustment for cigarette smoking, tea consumption, age, and body mass index, aspirin and chronic cough the odds ratio was found to be 4.41 (95% CI: 1.61-12.07). The most important finding of our study was the major GERD symptoms (heartburn and/or acid regurgitation once or more per week) among the individuals with the past history of exposure to SM toxic gas is substantially higher (4.4-fold) than normal populations.

Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease

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Tanabe Naoya

2012-04-01

Full Text Available Abstract Background The progression of chronic obstructive pulmonary disease (COPD considerably varies among patients. Those with emphysema identified by quantitative computed tomography (CT are associated with the rapid progression assessed by forced expiratory volume in one second (FEV1. However, whether the rate of the decline in lung function is independently affected by the regional distribution or the severity of emphysema in the whole lung is unclear. Methods We followed up 131 male patients with COPD for a median of 3.7 years. We measured wall area percent (WA% in right apical segmental bronchus, total lung volume, percent low attenuation volume (LAV%, and the standard deviation (SD of LAV% values from CT images of 10 isovolumetric partitions (SD-LAV as an index of cranial-caudal emphysema heterogeneity. Annual changes in FEV1 were then determined using a random coefficient model and relative contribution of baseline clinical parameters, pulmonary function, and CT indexes including LAV%, SD-LAV, and WA% to annual changes in FEV1 were examined. Results The mean (SD annual change in FEV1 was −44.4 (10.8 mL. Multivariate random coefficient model showed that higher baseline FEV1, higher LAV%, current smoking, and lower SD-LAV independently contributed to an excessive decline in FEV1, whereas ratio of residual volume to total lung capacity, ratio of diffusing capacity to alveolar ventilation, and WA% did not, after adjusting for age, height, weight, and ratio of CT-measured total lung volume to physiologically-measured total lung capacity. Conclusions A more homogeneous distribution of emphysema contributed to an accelerated decline in FEV1 independently of baseline pulmonary function, whole-lung emphysema severity, and smoking status. In addition to whole-lung analysis of emphysema, CT assessment of the cranial-caudal distribution of emphysema might be useful for predicting rapid, progressive disease and for developing a targeted

Geographic Distribution of Chagas Disease Vectors in Brazil Based on Ecological Niche Modeling

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Rodrigo Gurgel-Gonçalves

2012-01-01

Full Text Available Although Brazil was declared free from Chagas disease transmission by the domestic vector Triatoma infestans, human acute cases are still being registered based on transmission by native triatomine species. For a better understanding of transmission risk, the geographic distribution of Brazilian triatomines was analyzed. Sixteen out of 62 Brazilian species that both occur in >20 municipalities and present synanthropic tendencies were modeled based on their ecological niches. Panstrongylus geniculatus and P. megistus showed broad ecological ranges, but most of the species sort out by the biome in which they are distributed: Rhodnius pictipes and R. robustus in the Amazon; R. neglectus, Triatoma sordida, and T. costalimai in the Cerrado; R. nasutus, P. lutzi, T. brasiliensis, T. pseudomaculata, T. melanocephala, and T. petrocchiae in the Caatinga; T. rubrovaria in the southern pampas; T. tibiamaculata and T. vitticeps in the Atlantic Forest. Although most occurrences were recorded in open areas (Cerrado and Caatinga, our results show that all environmental conditions in the country are favorable to one or more of the species analyzed, such that almost nowhere is Chagas transmission risk negligible.

The pattern and distribution of communicable diseases among ...

African Journals Online (AJOL)

Background: Global and regional estimates show that non-communicable diseases are rising in importance relative to other causes of ill health as populations age and the fight continues against communicable diseases. However, communicable diseases remain a major cause of mortality and morbidity in the developing ...

75 FR 16012 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR...

Science.gov (United States)

2010-03-31

... distribution of power and responsibilities among the various levels of government, as specified in EO 13132... of the EO has the potential to influence the regulation. This action is not subject to EO 13045... acid plants; (x) Petroleum refineries; (xi) Lime plants; (xii) Phosphate rock processing plants; (xiii...

A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, Córdoba, Spain; VIII-XII centuries CE).

Science.gov (United States)

Viciano, Joan; De Luca, Stefano; López-Lázaro, Sandra; Botella, Daniel; Diéguez-Ramírez, Juan Pablo

2015-01-01

Pituitary gigantism is a rare endocrine disorder caused by hypersecretion of growth hormone during growing period. Individuals with this disorder have an enormous growth in height and associated degenerative changes. The continued hypersecretion of growth hormone during adulthood leads to acromegaly, a condition related to the disproportionate bone growth of the skull, hands and feet. The skeletal remains studied belong to a young adult male from the Jewish necropolis of "Ronda Sur" in Lucena (Córdoba, Spain, VIII-XII centuries CE). The individual shows a very large and thick neurocranium, pronounced supraorbital ridges, an extremely prominent occipital protuberance, and an extremely large and massive mandible. Additional pathologies include enlargement of the vertebral bodies with degenerative changes, thickened ribs, and a slight increased length of the diaphysis with an increased cortical bone thickness of lower limbs. Comparative metric analysis of the mandible with other individuals from the same population and a contemporary Mediterranean population shows a trend toward acromegalic morphology. This case is an important contribution in paleopathological literature because it is a rare condition that has not been widely documented in ancient skeletal remains.

Distributed cognition and process management enabling individualized translational research: The NIH Undiagnosed Diseases Program experience

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Amanda E Links

2016-10-01

Full Text Available The National Institutes of Health Undiagnosed Diseases Program (NIH UDP applies translational research systematically to diagnose patients with undiagnosed diseases. The challenge is to implement an information system enabling scalable translational research. The authors hypothesized that similarly complex problems are resolvable through process management and the distributed cognition of communities. The team therefore built the NIH UDP Integrated Collaboration System (UDPICS to form virtual collaborative multidisciplinary research networks or communities. UDPICS supports these communities through integrated process management, ontology-based phenotyping, biospecimen management, cloud-based genomic analysis, and an electronic laboratory notebook. UDPICS provided a mechanism for efficient, transparent, and scalable translational research and thereby addressed many of the complex and diverse research and logistical problems of the NIH UDP. Full definition of the strengths and deficiencies of UDPICS will require formal qualitative and quantitative usability and process improvement measurement.

Distributed Cognition and Process Management Enabling Individualized Translational Research: The NIH Undiagnosed Diseases Program Experience.

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Links, Amanda E; Draper, David; Lee, Elizabeth; Guzman, Jessica; Valivullah, Zaheer; Maduro, Valerie; Lebedev, Vlad; Didenko, Maxim; Tomlin, Garrick; Brudno, Michael; Girdea, Marta; Dumitriu, Sergiu; Haendel, Melissa A; Mungall, Christopher J; Smedley, Damian; Hochheiser, Harry; Arnold, Andrew M; Coessens, Bert; Verhoeven, Steven; Bone, William; Adams, David; Boerkoel, Cornelius F; Gahl, William A; Sincan, Murat

2016-01-01

The National Institutes of Health Undiagnosed Diseases Program (NIH UDP) applies translational research systematically to diagnose patients with undiagnosed diseases. The challenge is to implement an information system enabling scalable translational research. The authors hypothesized that similar complex problems are resolvable through process management and the distributed cognition of communities. The team, therefore, built the NIH UDP integrated collaboration system (UDPICS) to form virtual collaborative multidisciplinary research networks or communities. UDPICS supports these communities through integrated process management, ontology-based phenotyping, biospecimen management, cloud-based genomic analysis, and an electronic laboratory notebook. UDPICS provided a mechanism for efficient, transparent, and scalable translational research and thereby addressed many of the complex and diverse research and logistical problems of the NIH UDP. Full definition of the strengths and deficiencies of UDPICS will require formal qualitative and quantitative usability and process improvement measurement.

The projection of malignant diseases distribution in Yugoslavia with a special regard to Belgrade up to the year 2020

International Nuclear Information System (INIS)

Djordjevic, M.

2002-01-01

The paper presents data based on a 30-year period of descriptive and analytic studies conducted in Yugoslavia. It includes geographical distribution of malignant diseases and assessment of their frequency according to gender and age and the projection up to the year 2020. (author)

El reinado del Cornificio y el exilio de las Musas. El filósofo educado en las Artes en la Antigüedad arcaica y en la Europa medieval hasta el siglo XII

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Diego Pintado

2016-12-01

Full Text Available Este estudio describe y analiza el tránsito de un paradigma educativo (antiguo, clásico y medieval a un nuevo paradigma (el universitario, hacia el siglo XII. Se examina el origen y el desarrollo de un paradigma educativo y de formación que se remonta hasta la Grecia arcaica y que se mantuvo en vigencia en la Europa medieval hasta la creación de las universidades en el siglo XII. La tradición educativa de las artes liberales, conocida también como disciplinae cyclicae, es analizado como heredero directo de la tradición arcaica y pitagórica griega basada en la formación por las Musas. Se examinarán las similitudes y paralelismos entre las Musas y las Artes a la luz de la obra de Marciano Capela, De nuptis Philologiae et Mercuri. Luego se estudiará en modo conciso la figura del Cornificio, recreada por Juan de Salisbury en su Metalogicon, y se meditará sobre la relación de esta figura paradigmática y el contexto social, cultural, histórico, político y religioso que acaba dando lugar al nacimiento de los primeros estatutos universitarios. This paper treats the question of how the archaic and classical education paradigm is replaced by a new one based on institutionalization. It concerns about the origin and development of one education paradigm of schools, and the other paradigm, the institutional one, current and prevailing since the creation of the institution of university emerged about 12th century. The Liberal Arts education, also known as disciplinae cyclicae education, is analyzed according to the archaic and pithagoric greek tradition based on education by Muses. We will find similarities between Muses and Liberal Arts according to Martianus Capella’s work De nuptis Philologiae et Mercuri. Finally, we will observe this problem in John of Salisbury’ work Metalogicon and his central symbolic figure of the Cornificius.

PENGARUH PRESTASI AKADEMIK MATA DIKLAT PRODUKTIF AKUNTANSI, PRAKTIK KERJA INDUSTRI, DAN LINGKUNGAN KELUARGA TERHADAP KESIAPAN KERJA SISWA KELAS XII SMK NEGERI 1 KEBUMEN PROGRAM KEAHLIAN AKUNTANSI TAHUN AJARAN 2014/2015

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Ulinnajah Sofia Handayani

2015-11-01

Full Text Available SMK merupakan salah satu lembaga pendidikan kejuruan yang diselenggarakan dalam rangka mempersiapkan calon tenaga kerja untuk bekerja dalam bidang tertentu. Data SMK N 1 Kebumen menunjukkan adanya peningkatan lulusan SMK yang belum mendapatkan pekerjaan dari tahun 2013 ke 2014 sebesar 4%. Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya pengaruh prestasi akademik mata diklat produktif akuntansi, praktik kerja industri, dan lingkungan keluarga terhadap kesiapan kerja siswa kelas XII SMK Negeri 1 Kebumen program keahlian akuntansi.Populasi penelitian ini adalah siswa kelas XII Akuntansi sejumlah 120 siswa dan jumlah sampel sebanyak 92 siswa yang diambil dengan teknik pengambilan sampel proportional Random Sampling. Metode yang digunakan dalam pengambilan data adalah angket dan dokumentasi. Data variabel dianalisis dengan regresi berganda. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh prestasi akademik mata diklat produktif akuntansi, praktik kerja industri dan lingkungan keluarga terhadap kesiapan kerja siswa SMK Negeri 1 Kebumen sebesar 34,3%. Prestasi akademik mata diklat produktif akuntansi berpengaruh sebesar 6,16%. Praktik kerja industri berpengaruh sebesar 25,4%. Sedangkan lingkungan keluarga berpengaruh sebesar 9,86%. Vocational High School one of the educational institution that prepares the students to work in particular filed. Data of vocational high school 1 Kebumen show the increase students graduated from vocational high school have not gotten the job yet from 2013 to 2014 with amount 4%. The purpose of this study is to know whether there is influence of academic achievement accounting productive subject, on the job trining, and environmental family toward working readiness of the twelfth graders at state vocational high school 1 Kebumen who are taking accountancy program. The population in this study were students twelfth graders who are taking accountancy program with amount 120 students and the members of

Mathematical modelling of distribution of genes the damage of which leads to oncologic diseases in human population

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М. А. Бондаренко

2016-07-01

Full Text Available Carcinogenesis is subject of the research. The research aims at creating the mathematical model of carcinogenesis allowing assessing the distribution in human population of the genes which when damaged lead to oncology diseases. The main task is to build a probability mathematical model describing the quasistationary equilibrium of two contrary processes, and namely: 1 the process of reduction in population of the number of the aforesaid genes due to their mutative damage; 2 increase in population of the number of these genes due to the fact that persons with a few genes of the kind in their genotype acquire oncological diseases with higher probability at early stages of their lives and do not manage to reproduce themselves before they die, and so the growth of the total population size is more due to the reproduction of individuals with a high number of the a-genes. Assessment of the distribution of these genes in the population was carried out by determining the probability that a randomly selected individual from the population has one of the possible values (according to the literature, from 0 to 8 of the aforementioned genes.

In memoriam 1999

Index Scriptorium Estoniae

2000-01-01

Leopold Ennosaar (10. VI 1920-21. I), Silva Jaanberg (6. III 1922-5. X), Hilja Jõgi (31. X 1927-4. III), Lydia Jõõts (22. II 1911-27. XII), Ludvig Kruusmaa (19. XII 1920-7. XII), Ilmar Laasi (29. VII 1907-15. VIII), Urmas Mikk (25. XII 1957-15. I), Kaarel Pedak (12. V 1914-4. XII), Voldemar Peil (5. XI 1907-17. X), Aulin Rimm (27. VII 1930-21. IX), Igor Roosaar (6. XI 1915-17. X), Elle Tikerpäe (30. XI 1935-7. III), Aurora Tippe (23. I 1913-2. I), Ilmar Torn (1. I 1921-10. I), Tõnu Tulev (26. V 1955-26. VII), Voldemar Vaga (29. VI 1899-22. II), Ingi Vaher (31. V 1930-24. X), Aksel Vallaste (6. VI 1918-13. XII), Bernard Buffet (10. VII 1928-4. X), Raimo Kanerva (22. VIII 1941-17. IX).

Evaluation of the joint distribution at disease presentation of patients with rheumatoid arthritis: a large study across continents.

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Bergstra, Sytske Anne; Chopra, Arvind; Saluja, Manjit; Vega-Morales, David; Govind, Nimmisha; Huizinga, Tom W J; van der Helm-van Mil, Annette

2017-01-01

Genetic and environmental risk factors for rheumatoid arthritis (RA) are population dependent and may affect disease expression. Therefore, we studied tender and swollen joint involvement in patients newly diagnosed with RA in four countries and performed a subanalysis within countries to assess whether the influence of autoantibody positivity affected disease expression. Patients with symptom duration <2 years fulfilling the American College of Rheumatology/European League Against Rheumatism 2010 RA classification criteria were selected from METEOR (Measurement of Efficacy of Treatment in the Era of Outcome in Rheumatology), an international observational database, and the Dutch Leiden Early Arthritis Clinic. Indian (n=947), Mexican (n=141), South African (n=164) and Dutch (n=947) autoantibody-positive and negative patients with RA, matched by symptom duration, were studied for swollen and tender joint distribution. Between countries, the reported distribution of swollen joint distribution differed, with more knee synovitis in Mexico, South Africa and India compared with the Netherlands (37%, 36%, 30% and 13%) and more elbow (29%, 23%, 7%, 7%) and shoulder synovitis (21%, 11%, 0%, 1%) in Mexico and South Africa compared with India and the Netherlands.Since the number of autoantibody-negative patients in Mexico and South Africa was limited, Indian and Dutch autoantibody-positive and negative patients with RA were compared. The number of swollen and tender joints was higher in autoantibody-negative patients, but the overall distribution of involved joints was similar. Joint involvement at diagnosis does not differ between autoantibody-positive and negative patients with RA in India and the Netherlands. However, joint involvement is reported differently across countries. More research is needed whether these differences are cultural and/or pathogenetic.

Distribution pattern of MRI abnormalities within the knee and wrist of juvenile idiopathic arthritis patients: signature of disease activity

NARCIS (Netherlands)

Nusman, Charlotte M.; Hemke, Robert; Schonenberg, Dieneke; Dolman, Koert M.; van Rossum, Marion A. J.; van den Berg, J. Merlijn; Kuijpers, Taco W.; Maas, Mario

2014-01-01

The aim of this study in clinically active juvenile idiopathic arthritis (JIA) was to assess the frequency and distribution pattern of synovitis as hallmark of disease and additional soft-tissue and bony abnormalities on MRI in the knee and wrist as two target joints. MRI datasets of 153 clinically

INFLUENCE OF PARENTS' SOCIO-ECONOMIC STATUS AND VOCATIONAL LEARNING MOTIVATION TO LEARNING ACHIEVEMENT IN THE LESSON OF CHASSIS AND POWER TRANSDUCTOR FOR XII GRADE STUDENTS OF LIGHT VIHICLE ENGINEERING DEPARTMENT OF SMK PIRI 1 YOGYAKARTA IN ACADEMIC YEAR 2013/2014

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Indra Tri Setyawan

2014-06-01

Full Text Available The purpose of the study is to find the influence of parents’ socio-economic status and vocational learning motivation to learning achievement in the lesson of chassis and power transductor for XII grade students of SMK PIRI 1 Yogyakarta in the academic year 2013/2014. This research includes ex-post facto research conducted on the population 129 students with the sample 98 students. Data collection techniques in this research uses questionnaire instrument techniques for variable of parents’ socio-economic status and vocational learning motivation whereas documentation instrument techniques uses for variable of learning achievement the lesson of chassis and power transductor. Questionnaire was tested on 25 respondents. Data analysis techniques uses partial correlation analysis and regression analysis were preceded by prerequisite test that are normality test, linearity and multikolonieritas. The results of the data analysis is (1 parents’ socio-economic status (X1 influential positive and significant on learning achievement in the lesson of chassis and power transductor, (2 vocational learning motivation (X2 influential positive and significant on learning achievement in the lesson of chassis and power transductor, (3 parents’ socio-economic status (X1 and vocational learning motivation (X2 are jointly have positive and significant effect on learning achievement in the lesson of chassis and power transductor. Positive means that the higher the value of X1 and X2, the higher the value of Y, and vice versa. Thus, the socio-economic status of parents and the motivation to study vocational subjects affecting learning achievement the lesson of chassis and power transductor XII grade students of SMK PIRI 1 Yogyakarta in the academic year 2013/2014.

RANDOM QUADRATIC-FORMS AND THE BOOTSTRAP FOR U-STATISTICS

NARCIS (Netherlands)

DEHLING, H; MIKOSCH, T

We study the bootstrap distribution for U-statistics with special emphasis on the degenerate case. For the Efron bootstrap we give a short proof of the consistency using Mallows' metrics. We also study the i.i.d. weighted bootstrap [GRAPHICS] where (X(i)) and (xi(i)) are two i.i.d. sequences,

Demographic determinants of risk, colon distribution and density scores of diverticular disease.

Science.gov (United States)

Golder, Mark; Ster, Irina Chis; Babu, Pratusha; Sharma, Amita; Bayat, Muhammad; Farah, Abdulkadir

2011-02-28

To investigate associations between ethnicity, age and sex and the risk, colon distribution and density scores of diverticular disease (DD). Barium enemas were examined in 1000 patients: 410 male, 590 female; 760 whites, 62 Asians, 44 black africans (BAs), and 134 other blacks (OBs). Risks and diverticula density of left-sided DD (LSDD) and right-sided-component DD (RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic regression. Four hundred and forty-seven patients had DD (322 LSDD and 125 RSCDD). Adjusted risks: (1) LSDD: each year increase in age increased the odds by 6% (95% CI: 5-8, SE: 0.8%, P colonic DD might be more common and has higher diverticula density in the west than previously reported. BAs appear predisposed to DD, whereas other ethnic differences appear conserved following migration.

A Keck/DEIMOS spectroscopic survey of the faint M31 satellites AndIX, AndXI, AndXII and AndXIII†

Science.gov (United States)

Collins, M. L. M.; Chapman, S. C.; Irwin, M. J.; Martin, N. F.; Ibata, R. A.; Zucker, D. B.; Blain, A.; Ferguson, A. M. N.; Lewis, G. F.; McConnachie, A. W.; Peñarrubia, J.

2010-10-01

We present the first spectroscopic analysis of the faint M31 satellite galaxies, AndXI and AndXIII, as well as a re-analysis of existing spectroscopic data for two further faint companions, AndIX (correcting for an error in earlier geometric modelling that caused a misclassification of member stars in previous work) and AndXII. By combining data obtained using the Deep Imaging Multi-Object Spectrograph (DEIMOS) mounted on the Keck II telescope with deep photometry from the Suprime-Cam instrument on Subaru, we have identified the most probable members for each of the satellites based on their radial velocities (precise to several down to i ~ 22), distance from the centre of the dwarf spheroidal galaxies (dSphs) and their photometric [Fe/H]. Using both the photometric and spectroscopic data, we have also calculated global properties for the dwarfs, such as systemic velocities, metallicities and half-light radii. We find each dwarf to be very metal poor ([Fe/H] ~ -2 both photometrically and spectroscopically, from their stacked spectrum), and as such, they continue to follow the luminosity-metallicity relationship established with brighter dwarfs. We are unable to resolve dispersion for AndXI due to small sample size and low signal-to-noise ratio, but we set a 1σ upper limit of σv financial support of the W.M. Keck Foundation. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. ‡ E-mail: mlmc2@ast.cam.ac.uk

PANCHROMATIC HUBBLE ANDROMEDA TREASURY. XII. MAPPING STELLAR METALLICITY DISTRIBUTIONS IN M31

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Gregersen, Dylan; Seth, Anil C. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Williams, Benjamin F.; Dalcanton, Julianne J.; Johnson, L. C.; Lewis, Alexia R. [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Lang, Dustin [McWilliams Center for Cosmology, Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213 (United States); Girardi, Leó [Osservatorio Astronomico di Padova—INAF, Vicolo dell’Osservatori 5, I-35122 Padova (Italy); Skillman, Evan D. [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Bell, Eric [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Dolphin, Andrew E. [Raytheon, 1151 E. Hermans Road, Tucson, AZ 85706 (United States); Fouesneau, Morgan [MPIA, Koenigstuhl 17, D-69117 Heidelberg (Germany); Guhathakurta, Puragra; Hamren, Katherine M. [UCO/Lick Observatory, University of California at Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Kalirai, Jason [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Monachesi, Antonela [MPA, Garching (Germany); Olsen, Knut, E-mail: dylan.gregersen@utah.edu, E-mail: aseth@astro.utah.edu [NOAO, Tucson, AZ 85719 (United States)

2015-12-15

We present a study of spatial variations in the metallicity of old red giant branch stars in the Andromeda galaxy. Photometric metallicity estimates are derived by interpolating isochrones for over seven million stars in the Panchromatic Hubble Andromeda Treasury (PHAT) survey. This is the first systematic study of stellar metallicities over the inner 20 kpc of Andromeda’s galactic disk. We see a clear metallicity gradient of −0.020 ± 0.004 dex kpc{sup −1} from ∼4–20 kpc assuming a constant red giant branch age. This metallicity gradient is derived after correcting for the effects of photometric bias and completeness and dust extinction, and is quite insensitive to these effects. The unknown age gradient in M31's disk creates the dominant systematic uncertainty in our derived metallicity gradient. However, spectroscopic analyses of galaxies similar to M31 show that they typically have small age gradients that make this systematic error comparable to the 1σ error on our metallicity gradient measurement. In addition to the metallicity gradient, we observe an asymmetric local enhancement in metallicity at radii of 3–6 kpc that appears to be associated with Andromeda’s elongated bar. This same region also appears to have an enhanced stellar density and velocity dispersion.

Distribution of Short-Term and Lifetime Predicted Risks of Cardiovascular Diseases in Peruvian Adults

Science.gov (United States)

Quispe, Renato; Bazo-Alvarez, Juan Carlos; Burroughs Peña, Melissa S; Poterico, Julio A; Gilman, Robert H; Checkley, William; Bernabé-Ortiz, Antonio; Huffman, Mark D; Miranda, J Jaime

2015-01-01

Background Short-term risk assessment tools for prediction of cardiovascular disease events are widely recommended in clinical practice and are used largely for single time-point estimations; however, persons with low predicted short-term risk may have higher risks across longer time horizons. Methods and Results We estimated short-term and lifetime cardiovascular disease risk in a pooled population from 2 studies of Peruvian populations. Short-term risk was estimated using the atherosclerotic cardiovascular disease Pooled Cohort Risk Equations. Lifetime risk was evaluated using the algorithm derived from the Framingham Heart Study cohort. Using previously published thresholds, participants were classified into 3 categories: low short-term and low lifetime risk, low short-term and high lifetime risk, and high short-term predicted risk. We also compared the distribution of these risk profiles across educational level, wealth index, and place of residence. We included 2844 participants (50% men, mean age 55.9 years [SD 10.2 years]) in the analysis. Approximately 1 of every 3 participants (34% [95% CI 33 to 36]) had a high short-term estimated cardiovascular disease risk. Among those with a low short-term predicted risk, more than half (54% [95% CI 52 to 56]) had a high lifetime predicted risk. Short-term and lifetime predicted risks were higher for participants with lower versus higher wealth indexes and educational levels and for those living in urban versus rural areas (PPeruvian adults were classified as low short-term risk but high lifetime risk. Vulnerable adults, such as those from low socioeconomic status and those living in urban areas, may need greater attention regarding cardiovascular preventive strategies. PMID:26254303

Plague Circulation and Population Genetics of the Reservoir Rattus rattus: The Influence of Topographic Relief on the Distribution of the Disease within the Madagascan Focus

Science.gov (United States)

Brouat, Carine; Rahelinirina, Soanandrasana; Loiseau, Anne; Rahalison, Lila; Rajerison, Minoariso; Laffly, Dominique; Handschumacher, Pascal; Duplantier, Jean-Marc

2013-01-01

Background Landscape may affect the distribution of infectious diseases by influencing the population density and dispersal of hosts and vectors. Plague (Yersinia pestis infection) is a highly virulent, re-emerging disease, the ecology of which has been scarcely studied in Africa. Human seroprevalence data for the major plague focus of Madagascar suggest that plague spreads heterogeneously across the landscape as a function of the relief. Plague is primarily a disease of rodents. We therefore investigated the relationship between disease distribution and the population genetic structure of the black rat, Rattus rattus, the main reservoir of plague in Madagascar. Methodology/Principal Findings We conducted a comparative study of plague seroprevalence and genetic structure (15 microsatellite markers) in rat populations from four geographic areas differing in topology, each covering about 150–200 km2 within the Madagascan plague focus. The seroprevalence levels in the rat populations mimicked those previously reported for humans. As expected, rat populations clearly displayed a more marked genetic structure with increasing relief. However, the relationship between seroprevalence data and genetic structure differs between areas, suggesting that plague distribution is not related everywhere to the effective dispersal of rats. Conclusions/Significance Genetic diversity estimates suggested that plague epizootics had only a weak impact on rat population sizes. In the highlands of Madagascar, plague dissemination cannot be accounted for solely by the effective dispersal of the reservoir. Human social activities may also be involved in spreading the disease in rat and human populations. PMID:23755317

Arboreas voces solis luneque loquentes: la visita de Alejandro Magno a los árboles del sol y de la luna en las crónicas del siglo XII

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José Miguel De Toro Vidal

2016-08-01

Full Text Available El encuentro de Alejandro Magno con los árboles parlantes del Sol y de la Luna en un bosque sagrado de la India, constituye uno de los muchos episodios maravillosos de la leyenda alejandrina difundida en la Edad Media. El objetivo del presente artículo es estudiar el momento en que los cronistas deciden incorporar este pasaje en sus obras e indagar en las causas de esta decisión. Para ello se han revisado las crónicas universales del siglo XII y principios del XIII, cotejándolas con otras obras producidas en la época. Se aprecia que tanto la Historia Scholastica de Pedro Coméstor como los mapamundis contribuyeron a la aceptación del episodio. No obstante, la inclusión del pasaje en las crónicas no obedece tanto a la afirmación del encuentro con los árboles como un hecho cierto de la historia, sino al proyecto histórico-literario previsto por el autor de cada crónica.

Predictive modeling of coral disease distribution within a reef system.

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Gareth J Williams

2010-02-01

Full Text Available Diseases often display complex and distinct associations with their environment due to differences in etiology, modes of transmission between hosts, and the shifting balance between pathogen virulence and host resistance. Statistical modeling has been underutilized in coral disease research to explore the spatial patterns that result from this triad of interactions. We tested the hypotheses that: 1 coral diseases show distinct associations with multiple environmental factors, 2 incorporating interactions (synergistic collinearities among environmental variables is important when predicting coral disease spatial patterns, and 3 modeling overall coral disease prevalence (the prevalence of multiple diseases as a single proportion value will increase predictive error relative to modeling the same diseases independently. Four coral diseases: Porites growth anomalies (PorGA, Porites tissue loss (PorTL, Porites trematodiasis (PorTrem, and Montipora white syndrome (MWS, and their interactions with 17 predictor variables were modeled using boosted regression trees (BRT within a reef system in Hawaii. Each disease showed distinct associations with the predictors. Environmental predictors showing the strongest overall associations with the coral diseases were both biotic and abiotic. PorGA was optimally predicted by a negative association with turbidity, PorTL and MWS by declines in butterflyfish and juvenile parrotfish abundance respectively, and PorTrem by a modal relationship with Porites host cover. Incorporating interactions among predictor variables contributed to the predictive power of our models, particularly for PorTrem. Combining diseases (using overall disease prevalence as the model response, led to an average six-fold increase in cross-validation predictive deviance over modeling the diseases individually. We therefore recommend coral diseases to be modeled separately, unless known to have etiologies that respond in a similar manner to

Molecular Dynamics Simulation of Nanoindentation-induced Mechanical Deformation and Phase Transformation in Monocrystalline Silicon

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Jian Sheng-Rui

2008-01-01

Full Text Available AbstractThis work presents the molecular dynamics approach toward mechanical deformation and phase transformation mechanisms of monocrystalline Si(100 subjected to nanoindentation. We demonstrate phase distributions during loading and unloading stages of both spherical and Berkovich nanoindentations. By searching the presence of the fifth neighboring atom within a non-bonding length, Si-III and Si-XII have been successfully distinguished from Si-I. Crystallinity of this mixed-phase was further identified by radial distribution functions.

Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses

DEFF Research Database (Denmark)

Soricelli, A; Postiglione, A; Grivet-Fojaja, M R

1996-01-01

Iodine-123 labelled iomazenil (IMZ) is a specific tracer for the GABAA receptor, the dominant inhibitory synapse of the brain. The cerebral distribution volume (Vd) of IMZ may be taken as a quantitative measure of these synapses in Alzheimer's disease (AD), where synaptic loss tends indiscriminat...... simultaneously. Reduced values were found in all regions except in the occipital (visual) cortex. In particular, temporal and parietal cortex Vd was significantly (P...

Distribution of Short-Term and Lifetime Predicted Risks of Cardiovascular Diseases in Peruvian Adults.

Science.gov (United States)

Quispe, Renato; Bazo-Alvarez, Juan Carlos; Burroughs Peña, Melissa S; Poterico, Julio A; Gilman, Robert H; Checkley, William; Bernabé-Ortiz, Antonio; Huffman, Mark D; Miranda, J Jaime

2015-08-07

Short-term risk assessment tools for prediction of cardiovascular disease events are widely recommended in clinical practice and are used largely for single time-point estimations; however, persons with low predicted short-term risk may have higher risks across longer time horizons. We estimated short-term and lifetime cardiovascular disease risk in a pooled population from 2 studies of Peruvian populations. Short-term risk was estimated using the atherosclerotic cardiovascular disease Pooled Cohort Risk Equations. Lifetime risk was evaluated using the algorithm derived from the Framingham Heart Study cohort. Using previously published thresholds, participants were classified into 3 categories: low short-term and low lifetime risk, low short-term and high lifetime risk, and high short-term predicted risk. We also compared the distribution of these risk profiles across educational level, wealth index, and place of residence. We included 2844 participants (50% men, mean age 55.9 years [SD 10.2 years]) in the analysis. Approximately 1 of every 3 participants (34% [95% CI 33 to 36]) had a high short-term estimated cardiovascular disease risk. Among those with a low short-term predicted risk, more than half (54% [95% CI 52 to 56]) had a high lifetime predicted risk. Short-term and lifetime predicted risks were higher for participants with lower versus higher wealth indexes and educational levels and for those living in urban versus rural areas (PPeruvian adults were classified as low short-term risk but high lifetime risk. Vulnerable adults, such as those from low socioeconomic status and those living in urban areas, may need greater attention regarding cardiovascular preventive strategies. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Vitamin D in Saudi Arabia: Prevalence,distribution and disease associations.

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Al-Daghri, Nasser M

2018-01-01

More than 33 years have passed since the first paper highlighting vitamin D deficiency as a public health concern in Saudi Arabia was published in 1983. Despite "early" detection,it wasn't until the year 2010 where the interest in vitamin D research grew exponentially worldwide and was finally visible in Saudi clinical and academic areas. Since then,many landmark studies have been generated with regards to the physiologic functions of vitamin D,both skeletal and extra-skeletal. This review is limited to the prevalence,distribution A systematic review on the prevalence studies done in KSA from 2011 to 2016 was done and revealed that the prevalence of vitamin D deficiency (Saudi Arabia among different populations (adults,children and adolescents,newborns and pregnant/lactating women) is 81.0% (Confidence Interval 95% 68.0-90.0),in line with most neighboring Gulf countries. Vitamin D deficiency in KSA has been mostly associated with bone and insulin-resistant diseases but limited data are available to prove causality. In conclusion,there is a need to develop local consensus guidelines that will identify candidates for screening,monitoring and treating those who are at most risk for vitamin D deficiency complications. Copyright © 2016 Elsevier Ltd. All rights reserved.

Las mujeres nobles y el poder en los reinos de León y Castilla en el siglo XII: un estudio preliminar

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Simon BARTON

2012-03-01

Full Text Available El presente artículo analiza hasta qué punto las mujeres pertenecientes a la aristocracia eran capaces de ostentar el poder y ejercer su influencia en el ámbito de los reinos de León y Castilla durante el siglo XII. Pese a ser cierto que el acceso de las mujeres nobles al poder y al ejercicio de influencias se encontraba limitado por cuestiones de género, lo cual implicaba que se encontraban prácticamente excluidas de determinadas esferas de actividad relevantes, tales como la pertenencia a la curia real, estas mujeres estaban lejos de ser meras víctimas pasivas del dominio masculino, como a menudo se ha supuesto. Gracias a sus considerables recursos económicos, que administraban a través de las instituciones entrelazadas del señorío y la familia, y a su estrecha relación con la Iglesia, dichas mujeres estaban capacitadas para desempeñar papeles destacados en el ámbito público y ejercer un grado importante de poder y autoridad en su paso por el ciclo vital que iba desde el matrimonio hasta la viudedad. Dicho papel público no necesariamente se volvía más limitado tras la muerte del marido; si acaso, ganaba importancia, ya que las madres continuaban ofreciendo su apoyo a sus hijos y ejercían el mecenazgo, especialmente el religioso, a una escala sin precedentes.

Species distribution models and ecological suitability analysis for potential tick vectors of lyme disease in Mexico.

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Illoldi-Rangel, Patricia; Rivaldi, Chissa-Louise; Sissel, Blake; Trout Fryxell, Rebecca; Gordillo-Pérez, Guadalupe; Rodríguez-Moreno, Angel; Williamson, Phillip; Montiel-Parra, Griselda; Sánchez-Cordero, Víctor; Sarkar, Sahotra

2012-01-01

Species distribution models were constructed for ten Ixodes species and Amblyomma cajennense for a region including Mexico and Texas. The model was based on a maximum entropy algorithm that used environmental layers to predict the relative probability of presence for each taxon. For Mexico, species geographic ranges were predicted by restricting the models to cells which have a higher probability than the lowest probability of the cells in which a presence record was located. There was spatial nonconcordance between the distributions of Amblyomma cajennense and the Ixodes group with the former restricted to lowlands and mainly the eastern coast of Mexico and the latter to montane regions with lower temperature. The risk of Lyme disease is, therefore, mainly present in the highlands where some Ixodes species are known vectors; if Amblyomma cajennense turns out to be a competent vector, the area of risk also extends to the lowlands and the east coast.

Species Distribution Models and Ecological Suitability Analysis for Potential Tick Vectors of Lyme Disease in Mexico

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Patricia Illoldi-Rangel

2012-01-01

Full Text Available Species distribution models were constructed for ten Ixodes species and Amblyomma cajennense for a region including Mexico and Texas. The model was based on a maximum entropy algorithm that used environmental layers to predict the relative probability of presence for each taxon. For Mexico, species geographic ranges were predicted by restricting the models to cells which have a higher probability than the lowest probability of the cells in which a presence record was located. There was spatial nonconcordance between the distributions of Amblyomma cajennense and the Ixodes group with the former restricted to lowlands and mainly the eastern coast of Mexico and the latter to montane regions with lower temperature. The risk of Lyme disease is, therefore, mainly present in the highlands where some Ixodes species are known vectors; if Amblyomma cajennense turns out to be a competent vector, the area of risk also extends to the lowlands and the east coast.

Manoel de Barros em terras estrangeiras: o livro das ignorãças, “uma didática da invenção”, Poema XII.

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Tania Regina Vieira

2010-04-01

Full Text Available http://dx.doi.org/10.5007/2175-7968.2009v2n24p97 Este artigo tem por objetivo relacionar as obras de Manoel de Barros traduzidas para o espanhol, o francês e o inglês, assim como apresentar o Poema XII, de “Uma Didática da Invenção”, parte de O Livro das Ignorãças, e sua tradução para essas línguas. Breve análise acompanha o poema e suas traduções, que dão mostras do estilo ímpar do poeta matogrossense, cujo universo poético é formado por coisas banais retiradas do cotidiano do Pantanal. Como fundamentação teórica, são trazidos os conceitos de patronagem, de André Lefevere, e de significância, agramaticalidade, leitura mimética e leitura semiótica, empregados por Michael Riffaterre e retomados por Mário Laranjeira. O exame da distribuição espacial da massa gráfica do poema, chamada de visilegibilidade por Laranjeira, inicia a análise, em que são mencionadas também as modalidades tradutórias de Francis Aubert.

Distribution and components of interstitial inflammation and fibrosis in IgG4-related kidney disease: analysis of autopsy specimens.

Science.gov (United States)

Hara, Satoshi; Kawano, Mitsuhiro; Mizushima, Ichiro; Harada, Kenichi; Takata, Takuma; Saeki, Takako; Ubara, Yoshifumi; Sato, Yasuharu; Nagata, Michio

2016-09-01

IgG4-related kidney disease (IgG4-RKD) occasionally progresses to chronic renal failure and is pathologically characterized by IgG4-positive lymphoplasmacyte-rich tubulointerstitial nephritis with storiform fibrosis (bird's-eye pattern fibrosis). Although radiology reveals a heterogeneous distribution of affected areas in this disease, their true distribution within the whole kidney is still unknown because of difficulty in estimating this from needle biopsy samples. Using 5 autopsy specimens, the present study histologically characterized the distribution and components of interstitial inflammation and fibrosis in IgG4-RKD. Interstitial lymphoplasmacytic infiltration or fibrosis was observed in a variety of anatomical locations such as intracapsular, subcapsular, cortical, perivascular, and perineural regions heterogeneously in a patchy distribution. They tended to be more markedly accumulated around medium- and small-sized vessels. Storiform fibrosis was limited to the cortex. Immunostaining revealed nonfibrillar collagens (collagen IV and VI) and fibronectin predominance in the cortical lesion, including storiform fibrosis. In contrast, fibril-forming collagens (collagen I and III), collagen VI, and fibronectin were the main components in the perivascular lesion. In addition, α-smooth muscle actin-positive myofibroblasts were prominently accumulated in the early lesion and decreased with progression, suggesting that myofibroblasts produce extracellular matrices forming a peculiar fibrosis. In conclusion, perivascular inflammation or fibrosis of medium- and small-sized vessels is a newly identified pathologic feature of IgG4-RKD. Because storiform fibrosis contains mainly nonfibrillar collagens, "interstitial fibrosclerosis" would be a suitable term to reflect this. The relation between the location and components of fibrosis determined in whole kidney samples provides new clues to the pathophysiology underlying IgG4-RKD. Copyright © 2016 The Authors. Published

Study on Association between Spatial Distribution of Metal Mines and Disease Mortality: A Case Study in Suxian District, South China

Science.gov (United States)

Song, Daping; Jiang, Dong; Wang, Yong; Chen, Wei; Huang, Yaohuan; Zhuang, Dafang

2013-01-01

Metal mines release toxic substances into the environment and can therefore negatively impact the health of residents in nearby regions. This paper sought to investigate whether there was excess disease mortality in populations in the vicinity of the mining area in Suxian District, South China. The spatial distribution of metal mining and related activities from 1985 to 2012, which was derived from remote sensing imagery, was overlapped with disease mortality data. Three hotspot areas with high disease mortality were identified around the Shizhuyuan mine sites, i.e., the Dengjiatang metal smelting sites, and the Xianxichong mine sites. Disease mortality decreased with the distance to the mining and smelting areas. Population exposure to pollution was estimated on the basis of distance from town of residence to pollution source. The risk of dying according to disease mortality rates was analyzed within 7–25 km buffers. The results suggested that there was a close relationship between the risk of disease mortality and proximity to the Suxian District mining industries. These associations were dependent on the type and scale of mining activities, the area influenced by mining and so on. PMID:24135822

Ressenya a Delle Donne, Fulvio & Torró, Jaume (eds. L’immagine di Alfonso il Magnanimo tra letteratura e storia, tra Corona d’Aragona e Italia - La imatge d’Algons el Magnànim en la literatura i la Historiografia entre la Corona d’Aragó i Itàlia, Florència, SISMEL -Edizioni del Galluzzo , 2016, XII + 300 p. ISBN: 978-88-8450-691-7

Directory of Open Access Journals (Sweden)

Marta Marfany Simó

2016-12-01

Full Text Available Review to Delle Donne, Fulvio & Torró, Jaume (eds. L’immagine di Alfonso il Magnanimo tra letteratura e storia, tra Corona d’Aragona e Italia - La imatge d’Algons el Magnànim en la literatura i la Historiografia entre la Corona d’Aragó i Itàlia, Firenze, SISMEL -Edizioni del Galluzzo , 2016, XII + 300 p. ISBN: 978-88-8450-691-7

Coexisting diseases of moyamoya vasculopathy.

Science.gov (United States)

Wei, Yi-Chia; Liu, Chi-Hung; Chang, Ting-Yu; Chin, Shy-Chyi; Chang, Chien-Hung; Huang, Kuo-Lun; Chang, Yeu-Jhy; Peng, Tsung-I; Lee, Tsong-Hai

2014-07-01

Several coexisting diseases have been reported in patients with moyamoya vasculopathy (MMV), but studies of quasi-moyamoya disease (quasi-MMD) are rare. This study aims to investigate the frequency of known coexisting diseases in patients with quasi-MMD and to compare quasi-MMD with moyamoya disease (MMD). Between 2000 and 2011, we retrospectively screened patients with International Classification of Diseases, Ninth Revision, code of 4375 (MMD) in the Health Information System of our hospital. The vascular images of each patient were confirmed by 2 neurologists and 1 neuroradiologist based on the diagnostic criteria of Japan Ministry of Health and Welfare. We excluded the patients with missing images and erroneous diagnosis. Demographics, coexisting diseases, laboratory data, treatment, and recurrent strokes were recorded. The eligible patients were divided into quasi-MMD and MMD groups according to the presence or absence of coexisting diseases. MMV was found in 90 patients including 37 (41.1%) quasi-MMD and 53 (58.9%) MMD. Atherosclerosis (32.4%) and thyroid disease (29.7%) were the leading coexisting diseases in quasi-MMD. Patients with MMD became symptomatic in a bimodal age distribution, whereas patients with quasi-MMD became symptomatic in a single-peak distribution. The prognosis of recurrent strokes was similar between quasi-MMD and MMD based on Kaplan-Meier analysis. A bimodal distribution of onset age was noted in MMD, whereas a single-peak distribution was found in quasi-MMD. Coexisting diseases were usually underevaluated but were more common than expected in patients with MMV. Atherosclerosis and thyroid diseases were the leading coexisting diseases in different preferential age. Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Temporal and Spatial Distribution of Tick-Borne Disease Cases among Humans and Canines in Illinois (2000-2009

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John A. Herrmann

2014-01-01

Full Text Available Four tick-borne diseases (TBDs, anaplasmosis, ehrlichiosis, Lyme disease (LD, and Rocky Mountain spotted fever (RMSF, are endemic in Illinois. The prevalence of human and canine cases of all four TBDs rose over the study period with significant differences in geographic distribution within the state. Among human cases, there were associations between cases of RMSF and LD and total forest cover, seasonal precipitation, average mean temperature, racial-ethnic groups, and gender. Estimated annual prevalence of three canine TBDs exceeded human TBD cases significantly in each region. There was concordance in the number of human and canine cases by county of residence, in annual prevalence trends, and in time of year at which they were diagnosed. To account for multiple environmental risk factors and to facilitate early diagnosis of cases, integrated surveillance systems must be developed and communication between veterinarians, physicians, and public health agencies must be improved.

Clinical significance of the changes of serum levels of superoxide dismutase (SOD), endothelin (ET) and T cell subsets distribution type after treatment in patients with coronary heart disease

International Nuclear Information System (INIS)

Li Lin; Zhu Xuejun; Liu Sheguo

2005-01-01

Objective: To explore the changes in serum SOD, ET levels and T-lymphocyte subsets distribution type after treatment in patients with coronary heart disease. Methods: The levels of serum SOD, ET were detected with RIA and T-lymphocyte subsets distribution type was detected with monoclonal antibody method in 42 cases of coronary heart disease both before and after a course of treatment and 35 controls. Results: before treatment, the levels of serum ET were significantly higher than those in controls (P 4 /CD 8 ratio were significantly lower than those in controls (P 0.05). Conclusion: Detection of serum SOD, ET and CD 4 /CD 8 ratio is valuable for the diagnosis and outcome prediction in patients with coronary heart disease. (authors)

Comparison of geographic distributions of Irritable Bowel Syndrome with Inflammatory Bowel Disease fail to support common evolutionary roots: Irritable Bowel Syndrome and Inflammatory Bowel Diseases are not related by evolution.

Science.gov (United States)

Szilagyi, Andrew; Xue, Xiaoqing

2018-01-01

Irritable Bowel Syndrome (IBS) shares overlapping symptoms and some features of pathogenesis with Inflammatory Bowel Diseases (IBD: Crohn's disease [CD], and Ulcerative Colitis [UC]). Geographic markers such as latitude/sunshine and more recently lactase population distributions are found to be correlated with IBD. As a result of clinical and pathogenic similarities between the 2 conditions, some authorities questioned whether a connection exists between them. We compare IBS directly with IBD, and indirectly with geographic markers associated with IBD, in order to evaluate possible evolutionary links between IBS and IBD. Similar correlations may link IBS as a precursor to IBD and possibly other conditions which are geographically connected with IBD. Data from four systematic reviews on IBD incidence and prevalence, IBS prevalence, and lactase distributions were included. Pearson's correlations were used for comparisons, with IBD values log-transformed because of skewed distribution. The articles provided 18-28 complete set of national data. Direct comparison between IBS and IBD showed no significant correlations (r = -0.14, r = -0.06 for CD and UC prevalence, r = -0.10 for CD incidence). Indirect comparisons also failed to show correlations of IBS with lactase distributions (r = -0.17), sunshine (r = -0.2) or latitude (r = 0.097); however, there was significant correlation between lactase distributions and CD incidence (r = -0.84), prevalence (r = -0.55) and UC prevalence (r = -0.59). Both sunshine (r= -0.53) and latitude (r = 0.58) are also significantly related to CD incidence. It is concluded that IBS and IBD do not follow similar global geographic patterns. This suggests a lack of an evolutionary genetic background coincident with emergence of lactase persistence. As well, vitamin D has no obvious impact on development of IBS. Similarities with IBD may result from sub groups (not yet identified) within the current Rome

Influence of veiling glare in the image intensifier on cinefluorographic sensitometry

International Nuclear Information System (INIS)

Matsuda, Eiji; Sanada, Taizo; Hitomi, Go; Ishii, Koushi; Yoshida, Akira

1998-01-01

We have experienced variations in the shape of the cinesensitometric curve when the exposure field is greatly altered. The veiling glare that arises from the scattering of x-ray photons, electrons, and light in the x-ray image intensifier (X-I.I.) depends on the size of the exposure field. Also, the effect of adjacent chemicals that occurs during the development process depends on the size of the exposed area on film. The veiling glare in the X-I.I. and the adjacent chemical effect on cine film processing may be responsible for these phenomena. This study investigated the influences of veiling glare on the shape of the cinesensitometric curve. Results showed that the veiling glare of the X-I.I. acts to increase the sensitivity of the cinesensitometric curve on the X-I.I. when the exposed area on the X-I.I. is larger. (author)

Influence of veiling glare in the image intensifier on cinefluorographic sensitometry

Energy Technology Data Exchange (ETDEWEB)

Matsuda, Eiji; Sanada, Taizo; Hitomi, Go; Ishii, Koushi [Kawasaki Medical School, Kurashiki, Okayama (Japan). Hospital; Yoshida, Akira

1998-08-01

We have experienced variations in the shape of the cinesensitometric curve when the exposure field is greatly altered. The veiling glare that arises from the scattering of x-ray photons, electrons, and light in the x-ray image intensifier (X-I.I.) depends on the size of the exposure field. Also, the effect of adjacent chemicals that occurs during the development process depends on the size of the exposed area on film. The veiling glare in the X-I.I. and the adjacent chemical effect on cine film processing may be responsible for these phenomena. This study investigated the influences of veiling glare on the shape of the cinesensitometric curve. Results showed that the veiling glare of the X-I.I. acts to increase the sensitivity of the cinesensitometric curve on the X-I.I. when the exposed area on the X-I.I. is larger. (author)

Distribution, incidence and severity of viral diseases of yam ...

African Journals Online (AJOL)

A survey was conducted in major yam cultivation zones in Côte d'Ivoire in 2009 to determine the incidence, severity of viral diseases, and viruses associated with the infected plants. Incidence and severity of the viral diseases were estimated based on symptoms. Enzyme-linked immunosorbent assay (ELISA) and ...

Posterior white matter disease distribution as a predictor of amyloid angiopathy

Science.gov (United States)

Thanprasertsuk, Sekh; Martinez-Ramirez, Sergi; Pontes-Neto, Octavio Marques; Ni, Jun; Ayres, Alison; Reed, Anne; Swords, Kyleen; Gurol, M. Edip; Greenberg, Steven M.

2014-01-01

Objectives: We sought to examine whether a posterior distribution of white matter hyperintensities (WMH) is an independent predictor of pathologically confirmed cerebral amyloid angiopathy (CAA) and whether it is associated with MRI markers of CAA, in patients without lobar intracerebral hemorrhage. Methods: We developed a quantitative method to measure anteroposterior (AP) distribution of WMH. A retrospective cohort of patients without intracerebral hemorrhage and with pathologic evaluation of CAA was examined to determine whether posterior WMH distribution was an independent predictor of CAA (n = 59). The relationship of AP distributions of WMH to strictly lobar microbleeds (MBs) (n = 259) and location of dilated perivascular spaces (DPVS) (n = 85) was examined in a separate cohort of patients evaluated in a memory clinic. Results: A more posterior WMH distribution was found to be an independent predictor of pathologic evidence of CAA (p = 0.001, odds ratio [95% confidence interval] = 1.19 [1.07–1.32]), even in the subgroup without lobar MBs (p = 0.016, odds ratio [95% confidence interval] = 1.18 [1.03–1.36]). In the memory clinic cohort, strictly lobar MBs were independently associated with more posterior WMH distribution (p = 0.009). AP distribution of WMH was also associated with location of DPVS (p = 0.001), in that patients with predominant DPVS in the white matter over the basal ganglia harbored a more posterior WMH distribution. Conclusions: Our results suggest that AP distribution of WMH may represent an additional marker of CAA, irrespective of the presence of lobar hemorrhages. Classification of evidence: This study provides Class III evidence that there is a significant association between the AP distribution of WMH on MRI with the presence of pathologically confirmed CAA pathology. PMID:25063759

Mining heart disease risk factors in clinical text with named entity recognition and distributional semantic models.

Science.gov (United States)

Urbain, Jay

2015-12-01

We present the design, and analyze the performance of a multi-stage natural language processing system employing named entity recognition, Bayesian statistics, and rule logic to identify and characterize heart disease risk factor events in diabetic patients over time. The system was originally developed for the 2014 i2b2 Challenges in Natural Language in Clinical Data. The system's strengths included a high level of accuracy for identifying named entities associated with heart disease risk factor events. The system's primary weakness was due to inaccuracies when characterizing the attributes of some events. For example, determining the relative time of an event with respect to the record date, whether an event is attributable to the patient's history or the patient's family history, and differentiating between current and prior smoking status. We believe these inaccuracies were due in large part to the lack of an effective approach for integrating context into our event detection model. To address these inaccuracies, we explore the addition of a distributional semantic model for characterizing contextual evidence of heart disease risk factor events. Using this semantic model, we raise our initial 2014 i2b2 Challenges in Natural Language of Clinical data F1 score of 0.838 to 0.890 and increased precision by 10.3% without use of any lexicons that might bias our results. Copyright © 2015 Elsevier Inc. All rights reserved.

DHA supplementation for late onset Stargardt disease: NAT-3 study

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Giuseppe Querques

2010-06-01

Full Text Available Giuseppe Querques1, Pascale Benlian1, Bernard Chanu2, Nicolas Leveziel1, Gabriel Coscas1, Gisele Soubrane1, Eric H Souied11Department of Ophthalmology, University of Paris XII, Centre Hospitalier Intercommunal de Creteil, 2Department of Nutrition, University of Paris XII, Hopital Henry Mondor, Creteil, FranceBackground: We analyzed the effects of a docosahexaenoic acid (DHA supplementation in patients affected with late onset Stargardt disease (STGD.Methods: DHA (840 mg/day was given to 20 STGD patients for six months. A complete ophthalmologic examination, including best-corrected visual acuity (BCVA and multifocal electroretinogram (mfERG, was performed at inclusion day 0 (D0 and at month 6 (M6.Results: Overall, no statistical differences have been observed at M6 vs D0 as regards BCVA and mfERG (P > 0.05. Mild Improvement of BCVA and improvement of mfERG was noted in seven/40 eyes of four/20 patients. In the first patient, the peak of the a wave increased from 66 nV/deg² to 75.4 nV/deg² in the right eye (RE and 24.5 nV/deg² to 49.1 nV/deg² in the left eye (LE. The peak of the b wave improved from 122 nV/deg² to 157 nV/deg² in the RE, and 102 nV/deg² to 149 nV/deg² in the LE. In the second patient peaks of the a and b waves respectively increased from 11.8 nV/deg² to 72.1 nV/deg² and 53 nV/deg² to 185 nV/deg² in the RE. In the third patient the peak of the a wave increased from 37 nV/deg² to 43 nV/deg² in the RE, and from 31 nV/deg² to 45 nV/deg² in the LE; the peak of the b wave improved from 70 nV/deg² to 89 nV/deg² in the RE, and from 101 nV/deg² to 108 nV/deg² in the LE. In the fourth patient, the peak of the a wave increased from 39 nV/deg² to 42 nV/deg² in the RE, and from 40 nV/deg² to 43 nV/deg² in the LE; the peak of the b wave improved from 86 nV/deg² to 94 nV/deg² in the RE, and from 87 nV/deg² to 107 nV/deg² in the LE.Conclusion: DHA seems to influence some functional parameters in patients affected with

Regional distribution of ventilation and perfusion in patients with obstructive pulmonary disease and alpha/sub 1/-antitrypsin deficiency

Energy Technology Data Exchange (ETDEWEB)

Mostafa, A B.M.G.; Tulley, N J; Harding, L K; Stockley, R A

1983-08-01

Regional distribution of pulmonary ventilation and perfusion has been determined of 13 patients with chronic obstructive pulmonary disease (COPD). Eight patients had alpha/sub 1/-antitrypsin deficiency (..cap alpha../sub 1/ATD). Ventilation studies were carried out using xenon-133 (/sup 133/Xe) and krypton-81m (sup(81m)Kr) gases. Trapping indices were determined from the wash-out part of the xenon ventilation studies. Results obtained from patients were compared with those of normal controls. Ventilation studies with sup(81m)Kr showed pulmonary changes more clearly than did /sup 133/Xe studies and the trapping of radio-xenon was more extensive in lung bases than in apices whether or not the patients had ..cap alpha../sub 1/ ATD. The distribution of perfusion followed a pattern similar to that of ventilation, but did not differ statistically from that of the normal controls.

Disease spread across multiple scales in a spatial hierarchy: effect of host spatial structure and of inoculum quantity and distribution.

Science.gov (United States)

Gosme, Marie; Lucas, Philippe

2009-07-01

Spatial patterns of both the host and the disease influence disease spread and crop losses. Therefore, the manipulation of these patterns might help improve control strategies. Considering disease spread across multiple scales in a spatial hierarchy allows one to capture important features of epidemics developing in space without using explicitly spatialized variables. Thus, if the system under study is composed of roots, plants, and planting hills, the effect of host spatial pattern can be studied by varying the number of plants per planting hill. A simulation model based on hierarchy theory was used to simulate the effects of large versus small planting hills, low versus high level of initial infections, and aggregated versus uniform distribution of initial infections. The results showed that aggregating the initially infected plants always resulted in slower epidemics than spreading out the initial infections uniformly. Simulation results also showed that, in most cases, disease epidemics were slower in the case of large host aggregates (100 plants/hill) than with smaller aggregates (25 plants/hill), except when the initially infected plants were both numerous and spread out uniformly. The optimal strategy for disease control depends on several factors, including initial conditions. More importantly, the model offers a framework to account for the interplay between the spatial characteristics of the system, rates of infection, and aggregation of the disease.

Atypical Distribution of Late Gadolinium Enhancement of the Left Ventricle on Cardiac Magnetic Resonance in Classical Anderson-Fabry Disease

OpenAIRE

Kasuya, Shusuke; Suzuki, Masayo; Inaoka, Tsutomu; Odashima, Masayuki; Nakatsuka, Tomoya; Ishikawa, Rumiko; Tokuyama, Wataru; Terada, Hitoshi

2016-01-01

Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by a deficiency of alpha-galactosidase A. Approximately 50% of patients with AFD may have cardiac involvement. Gadolinium-enhanced cardiac magnetic resonance (CMR) is useful for the diagnosis of cardiac involvement of AFD by recognizing typical late gadolinium enhancement (LGE) patterns. We report a 48-year-old man with cardiac involvement in classical AFD, showing atypical distribution of the LGE at the mid-lateral...

Improved noninvasive assessment of coronary artery disease by quantitative analysis of regional stress myocardial distribution and washout of thallium-201

International Nuclear Information System (INIS)

Maddahi, J.; Garcia, E.V.; Berman, D.S.; Waxman, A.; Swan, H.J.C.; Forrester, J.

1981-01-01

Visual interpretation of stress-redistribution thallium-201 ( 201 Tl) scintigrams is subject to observer variability and is suboptimal for evaluation of extent of coronary artery disease (CAD). An objective, computerized technique has been developed that quantitatively expresses the relative space-time myocardial distribution of 201 Tl. Multiple-view, maximum-count circumferential profiles for stress myocardial distribution of 201 Tl and segmental percent washout were analyzed in a pilot group of 31 normal subjects and 20 patients with CAD to develop quantitative criteria for abnormality. Subsequently, quantitative analysis was applied prospectively to a group of 22 normal subjects and 45 CAD patients and compared with visual interpretation of scintigrams for detection and evaluation of CAD. The sensitivity and specificity of the quantitative technique (93% and 91%, respectively) were not significantly different from those of the visual method (91% and 86%). The quantitative analysis significantly (p 201 Tl imaging over the visual method in the left anterior descending artery (from 56% to 80%), left circumflex artery (from 34% to 63%) and right coronary artery (from 65% to 94%) without significant loss of specificity. Using quantitative analysis, sensitivity for detection of deseased vessels did not diminish as the number of vessels involved increased, as it did with visual interpretations. In patients with one-vessel disease, 86% of the lesions were detected by both techniques; however, in patients with three-vessel disease, quantitative analysis detected 83% of the lesions, while the sensitivity was only 53% for the visual method. Seventy percent of the coronary arteries with moderate

Widespread distribution and a new recombinant species of Brazilian virus associated with cotton blue disease

Directory of Open Access Journals (Sweden)

Silvie P

2008-10-01

Full Text Available Abstract Background Cotton blue disease (CBD, an important global cotton crop pathology responsible for major economic losses, is prevalent in the major cotton-producing states of Brazil. Typical CBD symptoms include stunting due to internodal shortening, leaf rolling, intense green foliage, and yellowing veins. Atypical CBD symptoms, including reddish and withered leaves, were also observed in Brazilian cotton fields in 2007. Recently, a Polerovirus named Cotton leafroll dwarf virus (CLRDV was shown to be associated with CBD. Results To understand the distribution and genetic diversity of CLRDV in Brazil, we analyzed 23 CBD-symptomatic plants from susceptible cotton varieties originating from five of the six most important cotton-growing states, from 2004–2007. Here, we report on CLRDV diversity in plants with typical or atypical CBD symptoms by comparing viral coat protein, RNA polymerase (RdRp, and intergenic region genomic sequences. Conclusion The virus had a widespread distribution with a low genetic diversity; however, three divergent isolates were associated with atypical CBD symptoms. These divergent isolates had a CLRDV-related coat protein but a distinct RdRp sequence, and probably arose from recombination events. Based on the taxonomic rules for the family Luteoviridae, we propose that these three isolates represent isolates of a new species in the genus Polerovirus.

Widespread distribution and a new recombinant species of Brazilian virus associated with cotton blue disease.

Science.gov (United States)

Silva, T F; Corrêa, R L; Castilho, Y; Silvie, P; Bélot, J-L; Vaslin, M F S

2008-10-20

Cotton blue disease (CBD), an important global cotton crop pathology responsible for major economic losses, is prevalent in the major cotton-producing states of Brazil. Typical CBD symptoms include stunting due to internodal shortening, leaf rolling, intense green foliage, and yellowing veins. Atypical CBD symptoms, including reddish and withered leaves, were also observed in Brazilian cotton fields in 2007. Recently, a Polerovirus named Cotton leafroll dwarf virus (CLRDV) was shown to be associated with CBD. To understand the distribution and genetic diversity of CLRDV in Brazil, we analyzed 23 CBD-symptomatic plants from susceptible cotton varieties originating from five of the six most important cotton-growing states, from 2004-2007. Here, we report on CLRDV diversity in plants with typical or atypical CBD symptoms by comparing viral coat protein, RNA polymerase (RdRp), and intergenic region genomic sequences. The virus had a widespread distribution with a low genetic diversity; however, three divergent isolates were associated with atypical CBD symptoms. These divergent isolates had a CLRDV-related coat protein but a distinct RdRp sequence, and probably arose from recombination events. Based on the taxonomic rules for the family Luteoviridae, we propose that these three isolates represent isolates of a new species in the genus Polerovirus.

Survey of Pediatric Infectious Diseases Society Members About Congenital Chagas Disease.

Science.gov (United States)

Edwards, Morven S; Abanyie, Francisca A; Montgomery, Susan P

2018-01-01

Participants in a survey about congenital Chagas disease, distributed electronically to Pediatric Infectious Diseases Society members, perceived having limited knowledge about congenital Trypanosoma cruzi infection. Most rarely or never consider the diagnosis in infants born to parents from Latin America. Improved awareness of congenital Chagas disease and assessment of at-risk infants is needed.

A review of trends in the distribution of vector-borne diseases: is international trade contributing to their spread?

Science.gov (United States)

de La Rocque, S; Balenghien, T; Halos, L; Dietze, K; Claes, F; Ferrari, G; Guberti, V; Slingenbergh, J

2011-04-01

It is difficult to determine the part that international trade has played in the expansion of vector-borne diseases, because of the multitude of factors that affect the transformation of habitats and the interfaces between vectors and hosts. The introduction of pathogens through trade in live animals or products of animal origin, as well as the arrival of arthropod vectors, is probably quite frequent but the establishment of an efficient transmission system that develops into a disease outbreak remains the exception. In this paper, based on well-documented examples, the authors review the ecological and epidemiological characteristics of vector-borne diseases that may have been affected in their spread and change of distribution by international trade. In addition, they provide a detailed analysis of the risks associated with specific trade routes and recent expansions of vector populations. Finally, the authors highlight the importance, as well as the challenges, of preventive surveillance and regulation. The need for improved monitoring of vector populations and a readiness to face unpredictable epidemiological events are also emphasised, since this will require rapid reaction, not least in the regulatory context.

Newcastle Disease Viruses Causing Recent Outbreaks Worldwide Show Unexpectedly High Genetic Similarity to Historical Virulent Isolates from the 1940s

Science.gov (United States)

Dimitrov, Kiril M.; Lee, Dong-Hun; Williams-Coplin, Dawn; Olivier, Timothy L.; Miller, Patti J.

2016-01-01

Virulent strains of Newcastle disease virus (NDV) cause Newcastle disease (ND), a devastating disease of poultry and wild birds. Phylogenetic analyses clearly distinguish historical isolates (obtained prior to 1960) from currently circulating viruses of class II genotypes V, VI, VII, and XII through XVIII. Here, partial and complete genomic sequences of recent virulent isolates of genotypes II and IX from China, Egypt, and India were found to be nearly identical to those of historical viruses isolated in the 1940s. Phylogenetic analysis, nucleotide distances, and rates of change demonstrate that these recent isolates have not evolved significantly from the most closely related ancestors from the 1940s. The low rates of change for these virulent viruses (7.05 × 10−5 and 2.05 × 10−5 per year, respectively) and the minimal genetic distances existing between these and historical viruses (0.3 to 1.2%) of the same genotypes indicate an unnatural origin. As with any other RNA virus, Newcastle disease virus is expected to evolve naturally; thus, these findings suggest that some recent field isolates should be excluded from evolutionary studies. Furthermore, phylogenetic analyses show that these recent virulent isolates are more closely related to virulent strains isolated during the 1940s, which have been and continue to be used in laboratory and experimental challenge studies. Since the preservation of viable viruses in the environment for over 6 decades is highly unlikely, it is possible that the source of some of the recent virulent viruses isolated from poultry and wild birds might be laboratory viruses. PMID:26888902

Here, There, and Everywhere: The Ubiquitous Distribution of the Immunosignaling Molecule Lysophosphatidylcholine and Its Role on Chagas Disease.

Science.gov (United States)

Silva-Neto, Mário Alberto C; Lopes, Angela H; Atella, Georgia C

2016-01-01

Chagas disease is a severe illness, which can lead to death if the patients are not promptly treated. The disease is caused by the protozoan parasite Trypanosoma cruzi, which is mostly transmitted by a triatomine insect vector. There are 8-10 million people infected with T. cruzi in the world, but the transmission of such disease by bugs occurs only in the Americas, especially Latin America. Chronically infected patients will develop cardiac diseases (30%) and up digestive, neurological, or mixed disorders (10%). Lysophosphatidylcholine (LPC) is the major phospholipid component of oxidized low-density lipoproteins associated with atherosclerosis-related tissue damage. Insect-derived LPC powerfully attracts inflammatory cells to the site of the insect bite, enhances parasite invasion, and inhibits the production of nitric oxide by T. cruzi-stimulated macrophages. The recognition of the ubiquitous presence of LPC on the vector saliva, its production by the parasite itself and its presence both on patient plasma and its role on diverse host × parasite interaction systems lead us to compare its distribution in nature with the title of the famous Beatles song "Here, There and Everywhere" recorded exactly 50 years ago in 1966. Here, we review the major findings pointing out the role of such molecule as an immunosignaling modulator of Chagas disease transmission. Also, we believe that future investigation of the connection of this ubiquity and the immune role of such molecule may lead in the future to novel methods to control parasite transmission, infection, and pathogenesis.

In memoriam 1998

Index Scriptorium Estoniae

1999-01-01

1998. a. surnud kunstnikke maailmas: César (César Baldaccini; 1. I 1921-6. XII), Lucio Costa (27. II 1902-13.VI), Egill Jacobsen(16. XII 1910-21. IV), Victor Pasmore (3. XII 1908-23. I), Antonio Saura (22. IX 1930-22. VII); Eestis: Eugen Kask (18. I 1918-11. V), Kaja Kärner (3. VIII 1920-1. VII), Agu Pihelga (3. VIII 1910-5. I), Emilda Trepp (21. VII 1912-30. I)

Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS.

Science.gov (United States)

Hachmöller, Oliver; Zibert, Andree; Zischka, Hans; Sperling, Michael; Groba, Sara Reinartz; Grünewald, Inga; Wardelmann, Eva; Schmidt, Hartmut H-J; Karst, Uwe

2017-12-01

At present, the copper chelator d-penicillamine (DPA) is the first-line therapy of Wilson's disease (WD), which is characterized by an excessive copper overload. Lifelong DPA treatments aim to reduce the amount of detrimental excess copper retention in the liver and other organs. Although DPA shows beneficial effect in many patients, it may cause severe adverse effects. Despite several years of copper chelation therapy, discontinuation of DPA therapy can be linked to a rapidly progressing liver failure, indicating a high residual liver copper load. In order to investigate the spatial distribution of remaining copper and additional elements, such as zinc and iron, in rat and human liver samples after DPA treatment, a high resolution (spotsize of 10μm) laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging method was applied. Untreated LPP -/- rats, an established animal model for WD, appeared with a high overall copper concentration and a copper distribution of hotspots distributed over the liver tissue. In contrast, a low (>2-fold decreased) overall copper concentration was detected in liver of DPA treated animals. Importantly, however, copper distribution was highly inhomogeneous with lowest concentrations in direct proximity to blood vessels, as observed using novel zonal analysis. A human liver needle biopsy of a DPA treated WD patient substantiated the finding of an inhomogeneous copper deposition upon chelation therapy. In contrast, comparatively homogenous distributions of zinc and iron were observed. Our study indicates that a high resolution LA-ICP-MS analysis of liver samples is excellently suited to follow efficacy of chelator therapy in WD patients. Copyright © 2017 Elsevier GmbH. All rights reserved.

[Tick-borne diseases].

Science.gov (United States)

Tissot Dupont, H; Raoult, D

1993-05-01

Due to their worldwide distribution, from hottest to coldest climates, and due to their behaviour, ticks are capable of transmitting numerous human and animal bacterial viral or parasitous diseases. Depending on the disease, they play the role of biological vector or intermediate host. In France, six tick borne diseases are of epidemiologic importance. Q fever (not often tick-borne), Mediterranean Spotted Fever, Lyme disease, Turalemia (human and animal), Babesiosis and Tick-borne Viral Encephalitis.

As parroquias do Porriño, Cans e Atios na documentación do mosteiro cisterciense de Santa María de Melón. Séculos XII e XIII

Directory of Open Access Journals (Sweden)

Gradín Fernández, Isis

2011-12-01

Full Text Available After the introduction and criteria of transcription, 31 papers are published from the twelfth and thirteenth centuries belonging to the Cistercian monastery of Santa Maria de Melon, specifically those that permit the reconstruction of old possessions, focusing on the current council of O Porriño -which was the monastery of San Miguel de Cans, absorbed by the cistercian monks of Melon. A paleographic and historical approximation of this documentation is done, which is complemented with the corresponding index of names and place names.

[gl] Trala introducción e criterios de transcripción, edítanse 31 documentos dos séculos XII e XIII pertencentes ó mosteiro cisterciense de Santa María de Melón, concretamente aqueles que permiten reconstruír as antigas posesións –centradas sobre o actual concello de O Porriño- do que foi o mosteiro de San Miguel de Cans, absorvido polos monxes cistercienses de Melón. Faise unha aproximación paleográfica e histórica da documentación, que se complementa cos correspondentes índices onomásticos e toponímicos.

Endocardial-epicardial distribution of myocardial perfusion reserve assessed by multidetector computed tomography in symptomatic patients without significant coronary artery disease

DEFF Research Database (Denmark)

Kühl, Jørgen Tobias; George, Richard T; Mehra, Vishal C

2016-01-01

(MPR) in humans. We aimed to test the hypothesis that MPR in all myocardial layers is determined by age, gender, and cardiovascular risk profile in patients with ischaemic symptoms or equivalent but without obstructive coronary artery disease (CAD). METHODS AND RESULTS: A total of 149 patients enrolled...... in endocardial-epicardial distribution of perfusion reserve may be demonstrated with static CT perfusion. Low MPR in all myocardial layers was observed specifically in obese patients....

Group distribution characteristics of lachrymal duct obstruction diseases in major Li Miao minority areas of Hainan province

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Hua-Li Zhou

2014-07-01

Full Text Available AIM: To determine the group distribution characteristics of lachrymal duct obstruction diseases in major Li Miao minority areas of Hainan province. METHODS: Totally 5 353 residents were selected and researched by randomized cluster sampling in the major Li Miao minority areas of Hainan province. Ocular examination and lachrymal duct flushing were carried out, and questionnaire survey on lachrymal duct obstruction was conducted. The ratio of lachrymal duct obstruction diseases and group distribution characteristics were analyzed based on above research. RESULTS: The prevalence ratios of lachrymal duct obstruction was 4.47% in major Li Miao minority areas of Hainan province, with 2.62% in urban area, and 5.93% in rural area respectively. Prevalence ratios of men and women group were 1.69% and 6.39% correspondingly. Difference between the two groups was statistically significant(χ2=67.2821, P=0.0000. The highest prevalence ratio was 40-69 year-old group, second one was 70-79 year-old group, especially for women in these groups. The prevalence ratios of Ledong, Lingshui, Baisha and Changjiang county were higher than those of Baoting, Qiongzhong county and Wuzhishan city. No significant difference was found between both eyes. CONCLUSION: In major Li Miao minority areas of Hainan province, lachrymal duct obstruction mainly occurs in 40-79 year-old patients, with specially higher ratio of women. Statistically, significant difference of the prevalence ratio between urban and rural areas exists. The higher prevalence ratio is attributed to age, gender, geographical location, climate condition, health environment and so on. The prevalence ratio is higher in the dry and windy areas than in the humid and less windy areas.

Muusika : Kremer tuleb üllatama. Bartokiga Pariisis. Raimo Kangro CD kiitvad arvustused. Festivalikorraldajad ühendavad jõud. EOÜ kolmas tegevusaasta. Jüri Pärg 50 aastat laval. Harri Vasar 75. Ernesaksa nimelised stipendiumid / Heili Vaus-Tamm

Index Scriptorium Estoniae

Vaus-Tamm, Heili, 1961-

2001-01-01

Tartus ja Tallinnas annab kontserte Gidon Kremer ja tema orkester Kremerata Baltica. 30.XI toimus Pariisis Liszti saalis HonEst Quintette debüütkontsert, kus kanti ette Bela Bartoki kammerloomingut. Saksa muusikaajakirjad Fono Forum ning Piano News arvustavad Raimo Kangro hiljuti välja antud CDd. 11.XII kohtusid kultuuriministeeriumis süvamuusikafestivalide korraldajad. 7.XII tuli EMA orelisaalis kokku Eesti Orelisõprade Ühingu aastakoosolek, juhatuse esimees A.-P. Lattik. Jüri Pärg märkis soolokontserdiga 25.XII Estonia talveaias oma 70. sünnipäeva ja 50 lava-aastat. Estonia talveaias meenutatukse Harri Vasarat, kes saanuks 75. aastaseks. 15.XII antakse TÜ aulas traditsioonilisel jõulukontserdil üle tänavused Gustav Ernesaksa nimelised stipendiumid.

Identification of high risk areas for avian influenza outbreaks in California using disease distribution models.

Directory of Open Access Journals (Sweden)

Jaber Belkhiria

Full Text Available The coexistence of different types of poultry operations such as free range and backyard flocks, large commercial indoor farms and live bird markets, as well as the presence of many areas where wild and domestic birds co-exist, make California susceptible to avian influenza outbreaks. The 2014-2015 highly pathogenic Avian Influenza (HPAI outbreaks affecting California and other states in the United States have underscored the need for solutions to protect the US poultry industry against this devastating disease. We applied disease distribution models to predict where Avian influenza is likely to occur and the risk for HPAI outbreaks is highest. We used observations on the presence of Low Pathogenic Avian influenza virus (LPAI in waterfowl or water samples at 355 locations throughout the state and environmental variables relevant to the disease epidemiology. We used two algorithms, Random Forest and MaxEnt, and two data-sets Presence-Background and Presence-Absence data. The models performed well (AUCc > 0.7 for testing data, particularly those using Presence-Background data (AUCc > 0.85. Spatial predictions were similar between algorithms, but there were large differences between the predictions with Presence-Absence and Presence-Background data. Overall, predictors that contributed most to the models included land cover, distance to coast, and broiler farm density. Models successfully identified several counties as high-to-intermediate risk out of the 8 counties with observed outbreaks during the 2014-2015 HPAI epizootics. This study provides further insights into the spatial epidemiology of AI in California, and the high spatial resolution maps may be useful to guide risk-based surveillance and outreach efforts.

Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.

Science.gov (United States)

Hotez, Peter J; Kamath, Aruna

2009-08-25

The neglected tropical diseases (NTDs) are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA), and together produce a burden of disease that may be equivalent to up to one-half of SSA's malaria disease burden and more than double that caused by tuberculosis. Approximately 85% of the NTD disease burden results from helminth infections. Hookworm infection occurs in almost half of SSA's poorest people, including 40-50 million school-aged children and 7 million pregnant women in whom it is a leading cause of anemia. Schistosomiasis is the second most prevalent NTD after hookworm (192 million cases), accounting for 93% of the world's number of cases and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46-51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease representing a significant cause of disability and reduction in the region's agricultural productivity. There is a dearth of information on Africa's non-helminth NTDs. The protozoan infections, human African trypanosomiasis and visceral leishmaniasis, affect almost 100,000 people, primarily in areas of conflict in SSA where they cause high mortality, and where trachoma is the most prevalent bacterial NTD (30 million cases). However, there are little or no data on some very important protozoan infections, e.g., amebiasis and toxoplasmosis; bacterial infections, e.g., typhoid fever and non-typhoidal salmonellosis, the tick-borne bacterial zoonoses, and non-tuberculosis mycobaterial infections; and arboviral infections. Thus, the overall burden of Africa's NTDs may be severely underestimated. A full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur.

Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.

Directory of Open Access Journals (Sweden)

Peter J Hotez

Full Text Available The neglected tropical diseases (NTDs are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA, and together produce a burden of disease that may be equivalent to up to one-half of SSA's malaria disease burden and more than double that caused by tuberculosis. Approximately 85% of the NTD disease burden results from helminth infections. Hookworm infection occurs in almost half of SSA's poorest people, including 40-50 million school-aged children and 7 million pregnant women in whom it is a leading cause of anemia. Schistosomiasis is the second most prevalent NTD after hookworm (192 million cases, accounting for 93% of the world's number of cases and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46-51 million cases and onchocerciasis (37 million cases are also widespread in SSA, each disease representing a significant cause of disability and reduction in the region's agricultural productivity. There is a dearth of information on Africa's non-helminth NTDs. The protozoan infections, human African trypanosomiasis and visceral leishmaniasis, affect almost 100,000 people, primarily in areas of conflict in SSA where they cause high mortality, and where trachoma is the most prevalent bacterial NTD (30 million cases. However, there are little or no data on some very important protozoan infections, e.g., amebiasis and toxoplasmosis; bacterial infections, e.g., typhoid fever and non-typhoidal salmonellosis, the tick-borne bacterial zoonoses, and non-tuberculosis mycobaterial infections; and arboviral infections. Thus, the overall burden of Africa's NTDs may be severely underestimated. A full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur.

Agrin in Alzheimer's Disease: Altered Solubility and Abnormal Distribution within Microvasculature and Brain Parenchyma

Science.gov (United States)

Donahue, John E.; Berzin, Tyler M.; Rafii, Michael S.; Glass, David J.; Yancopoulos, George D.; Fallon, Justin R.; Stopa, Edward G.

1999-05-01

Agrin is a heparan sulfate proteoglycan that is widely expressed in neurons and microvascular basal lamina in the rodent and avian central nervous system. Agrin induces the differentiation of nerve-muscle synapses, but its function in either normal or diseased brains is not known. Alzheimer's disease (AD) is characterized by loss of synapses, changes in microvascular architecture, and formation of neurofibrillary tangles and senile plaques. Here we have asked whether AD causes changes in the distribution and biochemical properties of agrin. Immunostaining of normal, aged human central nervous system revealed that agrin is expressed in neurons in multiple brain areas. Robust agrin immunoreactivity was observed uniformly in the microvascular basal lamina. In AD brains, agrin is highly concentrated in both diffuse and neuritic plaques as well as neurofibrillary tangles; neuronal expression of agrin also was observed. Furthermore, patients with AD had microvascular alterations characterized by thinning and fragmentation of the basal lamina. Detergent extraction and Western blotting showed that virtually all the agrin in normal brain is soluble in 1% SDS. In contrast, a large fraction of the agrin in AD brains is insoluble under these conditions, suggesting that it is tightly associated with β -amyloid. Together, these data indicate that the agrin abnormalities observed in AD are closely linked to β -amyloid deposition. These observations suggest that altered agrin expression in the microvasculature and the brain parenchyma contribute to the pathogenesis of AD.

Distribution of cow-calf producers' beliefs regarding gathering and holding their cattle and observing animal movement restrictions during an outbreak of foot-and-mouth disease.

Science.gov (United States)

Delgado, Amy H; Norby, Bo; Scott, H Morgan; Dean, Wesley; McIntosh, W Alex; Bush, Eric

2014-12-01

The voluntary cooperation of producers with disease control measures such as movement restrictions and gathering cattle for testing, vaccination, or depopulation is critical to the success of many disease control programs. A cross-sectional survey was conducted in Texas in order to determine the distribution of key beliefs about obeying movement restrictions and gathering and holding cattle for disease control purposes. Two questionnaires were developed and distributed to separate representative samples of Texas cow-calf producers, respectively. The context for each behavior was provided through the use of scenarios in the questionnaire. Belief strength was measured using a 7-point Likert-like scale. Producers surveyed were unsure about the possible negative consequences of gathering and holding their cattle when requested by authorities, suggesting a key need for communication in this area during an outbreak. Respondents identified a lack of manpower and/or financial resources to gather and hold cattle as barriers to their cooperation with orders to gather and hold cattle. Producers also expressed uncertainty about the efficacy of movement restrictions to prevent the spread of foot-and-mouth disease and concern about possible feed shortages or animal suffering. However, there are emotional benefits to complying with movement restrictions and strong social expectations of cooperation with any movement bans put in place. Published by Elsevier B.V.

Elemental distribution in human femoral head

Energy Technology Data Exchange (ETDEWEB)

Santos, C., E-mail: catia.santos@itn.pt [Dep. Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal); Centro de Física Nuclear da Universidade de Lisboa, 1649-003 Lisboa (Portugal); Campus Tecnológico e Nuclear, IST/CTN, Universidade Técnica de Lisboa E.N. 10, 2686-953 Sacavém (Portugal); Fonseca, M. [Dep. Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal); Centro de Física Nuclear da Universidade de Lisboa, 1649-003 Lisboa (Portugal); Universidade Europeia|Laureate International Universities, 1500-210 Lisboa (Portugal); Corregidor, V. [Campus Tecnológico e Nuclear, IST/CTN, Universidade Técnica de Lisboa E.N. 10, 2686-953 Sacavém (Portugal); Silva, H. [Dep. Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal); Centro de Física Nuclear da Universidade de Lisboa, 1649-003 Lisboa (Portugal); Campus Tecnológico e Nuclear, IST/CTN, Universidade Técnica de Lisboa E.N. 10, 2686-953 Sacavém (Portugal); Luís, H.; Jesus, A.P. [Dep. Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal); Centro de Física Nuclear da Universidade de Lisboa, 1649-003 Lisboa (Portugal); and others

2014-07-15

Osteoporosis is the most common bone disease with severe symptoms and harmful effects on the patient quality of life. Because abnormal distribution and concentration of the major and trace elements may help to characterize the disease, ion beam analysis is applied to the study of bone samples. Proton Induced X-ray Emission and Elastic Backscattering Spectrometry are applied for qualitative and quantitative analysis of an osteoporotic bone sample, for the determination of the Ca/P ratio and analysis of the distribution of major and trace elements. The analysis was made both in trabecular and cortical bone and the results are in agreement with the information found in literature.

Risk of Subclinical Micrometastatic Disease in the Supraclavicular Nodal Bed According to the Anatomic Distribution in Patients With Advanced Breast Cancer

International Nuclear Information System (INIS)

Reed, Valerie K.; Cavalcanti, Jose L.; Strom, Eric A.; Perkins, George H.; Oh, Julia L.; Tereffe, Welela; Yu, T.-K.; Yeung, Henry; Whitman, Gary J.; Bedrosian, Isabelle; Macapinlac, Homer A.; Buchholz, Thomas A.; Woodward, Wendy A.

2008-01-01

Purpose: To determine the anatomic distribution of gross supraclavicular nodes within the supraclavicular fossa using 2-deoxy-2-[F-18] fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) scans, and to evaluate likely coverage of specific regions of the supraclavicular fossa using standard radiation fields. Methods and Materials: We identified 33 patients with advanced or metastatic breast cancer who had a PET/CT scan demonstrating hypermetabolic supraclavicular lymph nodes in 2005. The locations of the involved lymph nodes were mapped onto a single CT set of images of the supraclavicular fossa. These lymph nodes were also mapped onto the treatment-planning CT dataset of 4 patients treated in our institution (2 patients with biopsy-proven supraclavicular nodes and 2 patients with clinically negative supraclavicular nodes). Results: We were able to determine the distribution of 52 supraclavicular lymph nodes in 32 patients. Of 32 patients, 28 (87%) had a history of metastatic disease, and 2 patients had isolated nodal recurrences. Five patients had supraclavicular nodes posterior to the vertebral body transverse process, and several lymph nodes were in close proximity to the medial field border, raising the possibility of geographic miss in these areas. Conclusions: In patients with locally advanced disease, increased coverage of the supraclavicular fossa medially and posteriorly may be warranted

Some evidence for skewed mating type distribution in Iranian populations of Rhynchosporium commune, the cause of barley scald disease

Directory of Open Access Journals (Sweden)

Arzanlou Mahdi

2016-07-01

Full Text Available Rhynchosporium commune (formerly known as Rhynchosporium secalis, the causal agent of scald disease on barley, is known to spread asexually by splash dispersed conidia. However, there are multiple lines of evidence for the possibility of a clandestine sexual cycle occurrence in this species including extensive genotypic diversity, equal distribution of mating type alleles across the world and expression of mating type genes. In the current study, the potential for the occurrence of a sexual cycle amongst the Iranian population of R. commune was assessed by analyzing distribution and frequency of the mating type alleles at both micro and macro-spatial scales. A total of 95 single-conidial R. commune isolates were obtained from different barley fields in Kurdistan province. Previously designed primers were applied in a multiplex PCR assay to study distribution and frequency of the mating type alleles within and between populations. Totally, 67 isolates were determined as MAT1-1 and the remaining 28 isolates as MAT1-2 throughout the sampling counties. The results obtained at a macro-spatial scale revealed that unlike Kamyaran county (both MAT1-1 and MAT1-2 at an equal ratio, an unequal distribution of mating type genes was dominant among R. commune isolates in both Mariwan and Dehgolan counties. Our findings support a predominantly asexual reproduction for Mariwan and Dehgolan counties and the possibility of sexual stage occurrence in Kamyarna county.

Βιβλιοκρισία του: Martin da Canal, Les Estoires de Venise, αγγλική μετάφραση, εισαγωγή και σχόλια LAURA K. MORREALE [Archivio del Litorale Adriatico XII], Padova 2009

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Μαρίνα ΚΟΥΜΑΝΟΥΔΗ

2012-03-01

Full Text Available Βιβλιοκρισία του: Martin da Canal, Les Estoires de Venise, αγγλική μετάφραση, εισαγωγή και σχόλια LAURA K. MORREALE [Archivio del Litorale Adriatico XII], Padova 2009, σσ. xxii + 175 [ΙSBN 978-88-8098-267-8].

Distribution of Aleutian mink disease virus contamination in the environment of infected mink farms.

Science.gov (United States)

Prieto, A; Fernández-Antonio, R; Díaz-Cao, J M; López, G; Díaz, P; Alonso, J M; Morrondo, P; Fernández, G

2017-05-01

Control and eradication of Aleutian Mink Disease Virus (AMDV) are a major concern for fur-bearing animal production. Despite notably reducing disease prevalence, current control programs are unable to prevent the reinfection of farms, and environmental AMDV persistence seems to play a major role regarding this issue. In this study 114 samples from different areas and elements of seven infected mink farms were analyzed by qPCR in order to evaluate the environmental distribution of AMDV load. Samples were classified into nine categories, depending on the type of sample and degree of proximity to the animals, the main source of infection. Two different commercial DNA extraction kits were employed in parallel for all samples. qPCR analysis showed 69.3% positive samples with one kit and 81.6% with the other, and significant differences between the two DNA extraction methods were found regarding AMDV DNA recovery. Regarding sample categorization, all categories showed a high percentage of AMDV positive samples (31%-100%). Quantification of positive samples showed a decrease in AMDV load from animal barns to the periphery of the farm. In addition, those elements in direct contact with animals, the street clothes and vehicles of farm workers and personal protective equipment used for sampling showed a high viral load, and statistical analysis revealed significant differences in AMDV load between the first and last categories. These results indicate high environmental contamination of positive farms, which is helpful for future considerations about cleaning and disinfection procedures and biosecurity protocols. Copyright © 2017 Elsevier B.V. All rights reserved.

Here, There and Everywhere: The Ubiquitous Distribution of the Immunosignaling Molecule Lysophosphatidylcholine and its Role on Chagas Disease

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Mario Alberto Cardoso Silva-Neto

2016-02-01

Full Text Available Chagas disease is a severe illness, which can lead to death if the patients are not promptly treated. The disease is caused by the protozoan parasite Trypanosoma cruzi, which is mostly transmitted by a triatomine insect vector. There are 8-10 million people infected with T. cruzi in the world, but the vector-borne transmission occurs only in the Americas, especially Latin America. About 30 % of chronically infected people develop cardiac diseases and up to 10 % develop digestive, neurological or mixed disorders. Lysophosphatydilcholine (LPC is the major phospholipid component of oxidized low-density lipoproteins associated with atherosclerosis-related tissue damage. Insect-derived LPC is a powerful chemoattractant for inflammatory cells at the site of the insect bite, enhances parasite invasion, and inhibits the production of nitric oxide (NO by T. cruzi-stimulated macrophages. The recognition of the ubiquitous presence of LPC on the vector saliva, its production by the parasite itself and its presence both on patient plasma as well as its role on diverse host x parasite interaction systems lead us to compare its distribution in nature with the title of the famous Beatles song Here, There and Everywhere recorded exactly 50 years ago in 1966. Here, we review the major findings pointing out the role of such molecule as an immunosignaling modulator of Chagas disease transmission. Also, we believe that future investigation of the connection of this ubiquity and the immune role of such molecule may lead in the future to novel methods to control parasite transmission, infection and pathogenesis.

RISK FACTORS FOR AND SPATIAL DISTRIBUTION OF LYMPHOPROLIFERATIVE DISEASE VIRUS (LPDV) IN WILD TURKEYS (MELEAGRIS GALLOPAVO) IN NEW YORK STATE, USA.

Science.gov (United States)

Alger, Katrina; Bunting, Elizabeth; Schuler, Krysten; Whipps, Christopher M

2017-07-01

Lymphoproliferative disease virus (LPDV) is an oncogenic avian retrovirus that was previously thought to exclusively infect domestic turkeys but was recently shown to be widespread in Wild Turkeys ( Meleagris gallopavo ) throughout most of the eastern US. In commercial flocks, the virus spreads between birds housed in close quarters, but there is little information about potential risk factors for infection in wild birds. Initial studies focused on distribution of LPDV nationally, but investigation of state-level data is necessary to assess potential predictors of infection and detect patterns in disease prevalence and distribution. We tested wild turkey bone marrow samples (n=2,538) obtained from hunter-harvested birds in New York State from 2012 to 2014 for LPDV infection. Statewide prevalence for those 3 yr was 55% with a 95% confidence interval (CI) of 53-57%. We evaluated a suite of demographic, anthropogenic, and land cover characteristics with logistic regression to identify potential predictors for infection based on odds ratio (OR). Age (OR=0.16, 95% CI=0.13-0.19) and sex (OR=1.3, 95% CI=1.03-1.24) were strong predictors of LPDV infection, with juveniles less likely to test positive than adults, and females more likely to test positive than males. The number of birds released during the state's 40-yr translocation program (OR=0.993, 95% CI=0.990-0.997) and the ratio of agriculture to forest cover (OR=1.13, 95% CI=1.03-1.19) were also predictive of LPDV infection. Prevalence distribution was analyzed using dual kernel density smoothing to produce a risk surface map, combined with Kulldorff's spatial scan statistic and the Anselin Local Moran's I to identify statistically significant geographic clusters of high or low prevalence. These methods revealed the prevalence of LPDV was high (>50%) throughout New York State, with regions of variation and several significant clusters. We revealed new information about the risk factors and distribution of LPDV in New

Geographical distribution of complement receptor type 1 variants and their associated disease risk.

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Thaisa Lucas Sandri

Full Text Available Pathogens exert selective pressure which may lead to substantial changes in host immune responses. The human complement receptor type 1 (CR1 is an innate immune recognition glycoprotein that regulates the activation of the complement pathway and removes opsonized immune complexes. CR1 genetic variants in exon 29 have been associated with expression levels, C1q or C3b binding and increased susceptibility to several infectious diseases. Five distinct CR1 nucleotide substitutions determine the Knops blood group phenotypes, namely Kna/b, McCa/b, Sl1/Sl2, Sl4/Sl5 and KCAM+/-.CR1 variants were genotyped by direct sequencing in a cohort of 441 healthy individuals from Brazil, Vietnam, India, Republic of Congo and Ghana.The distribution of the CR1 alleles, genotypes and haplotypes differed significantly among geographical settings (p≤0.001. CR1 variants rs17047660A/G (McCa/b and rs17047661A/G (Sl1/Sl2 were exclusively observed to be polymorphic in African populations compared to the groups from Asia and South-America, strongly suggesting that these two SNPs may be subjected to selection. This is further substantiated by a high linkage disequilibrium between the two variants in the Congolese and Ghanaian populations. A total of nine CR1 haplotypes were observed. The CR1*AGAATA haplotype was found more frequently among the Brazilian and Vietnamese study groups; the CR1*AGAATG haplotype was frequent in the Indian and Vietnamese populations, while the CR1*AGAGTG haplotype was frequent among Congolese and Ghanaian individuals.The African populations included in this study might have a selective advantage conferred to immune genes involved in pathogen recognition and signaling, possibly contributing to disease susceptibility or resistance.

Preliminary study of the distribution of dose in patients with Graves' disease undergoing examination of uptake of iodine-131 using Monte Carlo simulation

International Nuclear Information System (INIS)

Schwarcke, Marcelo; Marques, Tatiana; Nicolucci, Patricia; Baffa, Oswaldo; Bornemann, Clarissa

2010-01-01

Patients with Graves disease have a high hormonal disorder, which causes behavioral changes. One way to treat this disease is the use of high doses of 131 Iodine, requiring that the patient carries out the examination of 131 I uptake to estimate the activity to be administered. Using these data capture and compared with the simulated data using the Monte Carlo code PENELOPE is possible to determine a distribution of dose to the region surrounding the thyroid. As noted the difference between the simulated values and the experimentally obtained were 10.36%, thus showing the code of simulation for accurate determination of absorbed dose in tissue near the thyroid. (author)

Diseases of lodgepole pine

Science.gov (United States)

Frank G. Hawksworth

1964-01-01

Diseases are a major concern to forest managers throughout the lodgepole pine type. In many areas, diseases constitute the primary management problem. As might be expected for a tree that has a distribution from Baja California, Mexico to the Yukon and from the Pacific to the Dakotas, the diseases of chief concern vary in different parts of the tree's range. For...

Eesti videokunsti otsingutel / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2006-01-01

XII Pärnu rahvusvaheline video- ja filmifestival "Klassiahastus" Pärnu mudaravilas 18. ja 19. XI. Peapreemia sai Kristina Normanni video "Pribaldid", ära märgiti Moira Tierney video "Yoyoyogasmana". Inglismaal Brightonis 1.-3. XII toimuva festivali kava

Chromosome preference of disease genes and vectorization for the prediction of non-coding disease genes.

Science.gov (United States)

Peng, Hui; Lan, Chaowang; Liu, Yuansheng; Liu, Tao; Blumenstein, Michael; Li, Jinyan

2017-10-03

Disease-related protein-coding genes have been widely studied, but disease-related non-coding genes remain largely unknown. This work introduces a new vector to represent diseases, and applies the newly vectorized data for a positive-unlabeled learning algorithm to predict and rank disease-related long non-coding RNA (lncRNA) genes. This novel vector representation for diseases consists of two sub-vectors, one is composed of 45 elements, characterizing the information entropies of the disease genes distribution over 45 chromosome substructures. This idea is supported by our observation that some substructures (e.g., the chromosome 6 p-arm) are highly preferred by disease-related protein coding genes, while some (e.g., the 21 p-arm) are not favored at all. The second sub-vector is 30-dimensional, characterizing the distribution of disease gene enriched KEGG pathways in comparison with our manually created pathway groups. The second sub-vector complements with the first one to differentiate between various diseases. Our prediction method outperforms the state-of-the-art methods on benchmark datasets for prioritizing disease related lncRNA genes. The method also works well when only the sequence information of an lncRNA gene is known, or even when a given disease has no currently recognized long non-coding genes.

Simultaneous Observation of High Temperature Plasma of Solar Corona By TESIS CORONAS-PHOTON and XRT Hinode.

Science.gov (United States)

Reva, A.; Kuzin, S.; Bogachev, S.; Shestov, S.

2012-05-01

The Mg XII spectroheliograph is a part of instrumentation complex TESIS (satellite CORONAS-PHOTON). This instrument builds monochromatic images of hot plasma of the solar corona (λ = 8.42 Å, T>5 MK). The Mg XII spectroheliograph observed hot plasma in the non-flaring active-region NOAA 11019 during nine days. We reconstructed DEM of this active region with the help of genetic algorithm (we used data of the Mg XII spectroheliograph, XRT and EIT). Emission measure of the hot component amounts 1 % of the emission measure of the cool component.

Probability Model of Allele Frequency of Alzheimer’s Disease Genetic Risk Factor

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Afshin Fayyaz-Movaghar

2016-06-01

Full Text Available Background and Purpose: The identification of genetics risk factors of human diseases is very important. This study is conducted to model the allele frequencies (AFs of Alzheimer’s disease. Materials and Methods: In this study, several candidate probability distributions are fitted on a data set of Alzheimer’s disease genetic risk factor. Unknown parameters of the considered distributions are estimated, and some criterions of goodness-of-fit are calculated for the sake of comparison. Results: Based on some statistical criterions, the beta distribution gives the best fit on AFs. However, the estimate values of the parameters of beta distribution lead us to the standard uniform distribution. Conclusion: The AFs of Alzheimer’s disease follow the standard uniform distribution.

Statistical Mechanics of Prion Diseases

International Nuclear Information System (INIS)

Slepoy, A.; Singh, R. R. P.; Pazmandi, F.; Kulkarni, R. V.; Cox, D. L.

2001-01-01

We present a two-dimensional, lattice based, protein-level statistical mechanical model for prion diseases (e.g., mad cow disease) with concomitant prion protein misfolding and aggregation. Our studies lead us to the hypothesis that the observed broad incubation time distribution in epidemiological data reflect fluctuation dominated growth seeded by a few nanometer scale aggregates, while much narrower incubation time distributions for innoculated lab animals arise from statistical self-averaging. We model ''species barriers'' to prion infection and assess a related treatment protocol

Tectonic Divisions Based on Gravity Data and Earthquake Distribution Characteristics in the North South Seismic Belt, China

Science.gov (United States)

Tian, T.; Zhang, J.; Jiang, W.

2017-12-01

The North South Seismic Belt is located in the middle of China, and this seismic belt can be divided into 12 tectonic zones, including the South West Yunnan (I), the Sichuan Yunnan (II), the Qiang Tang (III), the Bayan Har (IV), the East Kunlun Qaidam (V), the Qi Lian Mountain (VI), the Tarim(VII), the East Alashan (VIII), the East Sichuan (IX), the Ordos(X), the Middle Yangtze River (XI) and the Edge of Qinghai Tibet Block (XII) zone. Based on the Bouguer Gravity data calculated from the EGM2008 model, the Euler deconvolution was used to obtain the edge of tectonic zone to amend the traditional tectonic divisions. In every tectonic zone and the whole research area, the logarithm of the total energy of seismic was calculated. The Time Series Analysis (TSA) for all tectonic zones and the whole area were progressed in R, and 12 equal divisions were made (A1-3, B1-3, C1-3, D1-3) by latitude and longitude as a control group. A simple linear trend fitting of time was used, and the QQ figure was used to show the residual distribution features. Among the zones according to Gravity anomalies, I, II and XII show similar statistical characteristic, with no earthquake free year (on which year there was no earthquake in the zone), and it shows that the more seismic activity area is more similar in statistical characteristic as the large area, no matter how large the zone is or how many earthquakes are in the zone. Zone IV, V, IX, III, VII and VIII show one or several seismic free year during 1970s (IV, V and IX) and 1980s (III, VII and VIII), which may implicate the earthquake activity were low decades ago or the earthquake catalogue were not complete in these zones, or both. Zone VI, X and XI show many earthquake free years even in this decade, which means in these zones the earthquake activity were very low even if the catalogue were not complete. In the control group, the earthquake free year zone appeared random and independent of the seismic density, and in all equal

Spatial distribution of diffuse, primitive, and classic amyloid-beta deposits and blood vessels in the upper laminae of the frontal cortex in Alzheimer disease.

Science.gov (United States)

Armstrong, R A; Cairns, N J; Lantos, P L

1998-12-01

The spatial distribution of the diffuse, primitive, and classic amyloid-beta deposits was studied in the upper laminae of the superior frontal gyrus in cases of sporadic Alzheimer disease (AD). Amyloid-beta-stained tissue was counterstained with collagen IV to determine whether the spatial distribution of the amyloid-beta deposits along the cortex was related to blood vessels. In all patients, amyloid-beta deposits and blood vessels were aggregated into distinct clusters and in many patients, the clusters were distributed with a regular periodicity along the cortex. The clusters of diffuse and primitive deposits did not coincide with the clusters of blood vessels in most patients. However, the clusters of classic amyloid-beta deposits coincided with those of the large diameter (>10 microm) blood vessels in all patients and with clusters of small-diameter (upper cortical laminae.

Preliminary study of the distribution of dose in patients with Graves disease undergoing examination of uptake of iodine-131 using Monte Carlo simulation

International Nuclear Information System (INIS)

Schwarcke, Marcelo; Marques, Tatiana; Alva, Mirko; Baffa, Oswaldo; Nicolucci, Patricia

2009-01-01

Patients with Graves' disease have a high hormonal disorder, which causes the change of behavior in society. One way to treat this disease is the use of doses of Iodine-131, requiring that the patient carries out the examination of uptake of 131 I estimates for completion of the activity to be administered. Using these data capture and compared with the simulated data using the Monte Carlo code Penelope is possible to determine a distribution of dose to the region surrounding the thyroid. As noted the difference between the simulated values and the experimentally obtained were 10.36%, thus showing the code of simulation for accurate determination of absorbed dose in tissue near the thyroid. (author)

Multilevel Analysis of Trachomatous Trichiasis and Corneal Opacity in Nigeria: The Role of Environmental and Climatic Risk Factors on the Distribution of Disease.

Science.gov (United States)

Smith, Jennifer L; Sivasubramaniam, Selvaraj; Rabiu, Mansur M; Kyari, Fatima; Solomon, Anthony W; Gilbert, Clare

2015-01-01

The distribution of trachoma in Nigeria is spatially heterogeneous, with large-scale trends observed across the country and more local variation within areas. Relative contributions of individual and cluster-level risk factors to the geographic distribution of disease remain largely unknown. The primary aim of this analysis is to assess the relationship between climatic factors and trachomatous trichiasis (TT) and/or corneal opacity (CO) due to trachoma in Nigeria, while accounting for the effects of individual risk factors and spatial correlation. In addition, we explore the relative importance of variation in the risk of trichiasis and/or corneal opacity (TT/CO) at different levels. Data from the 2007 National Blindness and Visual Impairment Survey were used for this analysis, which included a nationally representative sample of adults aged 40 years and above. Complete data were available from 304 clusters selected using a multi-stage stratified cluster-random sampling strategy. All participants (13,543 individuals) were interviewed and examined by an ophthalmologist for the presence or absence of TT and CO. In addition to field-collected data, remotely sensed climatic data were extracted for each cluster and used to fit Bayesian hierarchical logistic models to disease outcome. The risk of TT/CO was associated with factors at both the individual and cluster levels, with approximately 14% of the total variation attributed to the cluster level. Beyond established individual risk factors (age, gender and occupation), there was strong evidence that environmental/climatic factors at the cluster-level (lower precipitation, higher land surface temperature, higher mean annual temperature and rural classification) were also associated with a greater risk of TT/CO. This study establishes the importance of large-scale risk factors in the geographical distribution of TT/CO in Nigeria, supporting anecdotal evidence that environmental conditions are associated with increased

Association of erythrocyte deformability with red blood cell distribution width in metabolic diseases and thalassemia trait.

Science.gov (United States)

Vayá, Amparo; Alis, Rafael; Suescún, Marta; Rivera, Leonor; Murado, Julian; Romagnoli, Marco; Solá, Eva; Hernandez-Mijares, Antonio

2015-01-01

Increased red blood distribution width (RDW) in anemia is related to disturbances in the cellular surface/volume ratio, usually accompanied by morphological alterations, while it has been shown in inflammatory diseases that the activity of pro-inflammatory cytokines disturbing erythropoiesis increases RDW. Recently it has been reported that higher RDW is related with decreased erythrocyte deformability, and that it could be related with the association of RDW and increased risk of cardiovascular diseases. In order to analyze the influence of morphological alterations and proinflammatory status on the relationship between RDW and erythrocyte deformability, we analyzed erythrocyte deformability along with RDW and other hematological and biochemical parameters in 36 α-thalassemia, 20 β-thalassemia, 20 δβ-thalassemia trait carriers, 61 metabolic syndrome patients and 76 morbidly obese patients. RDW correlated inversely with erythrocyte deformability in minor β-thalassemia (r =-0.530, p thalassemia is often accompanied by more marked cell-shaped perturbations than other thalassemia traits. This could be the reason for this negative association only in this setting. Higher anisocytosis seems to be associated with greater morphologic alterations (shape/volume), which reduce erythrocyte deformability. The proinflammatory profile in metabolic patients can be related to the positive association of RDW with erythrocyte deformability found in these patients. However, further research is needed to explain the mechanisms underlying this association.

Lõhmus pluss Mäetamm pluss Külm / Anneli Porri

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2005-01-01

Eda Lõhmuse maalinäitus "Reaalne. Ebareaalne" Tallinna Linnagaleriis 7.-16. I. Neeme Külma näitus "Kui" Hobusepea galeriis 22. XII 2004-3. I 2005. Marko Mäetamme "Mälestusnäitus" Tallinna Linnagaleriis 20. XII 2004-10. I 2005

Differential distribution of striatal [123I]β-CIT in Parkinson's disease and progressive supranuclear palsy, evaluated with single-photon emission tomography

International Nuclear Information System (INIS)

Messa, C.; Volonte, M.A.; Fazio, F.; Zito, F.; Carpinelli, A.; D'Amico, A.; Rizzo, G.; Moresco, R.M.; Paulesu, E.; Franceschi, M.; Lucignani, G.

1998-01-01

Functional imaging of the presynaptic dopaminergic activity using single-photon emission tomography (SPET) and iodine-123 labelled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane ([ 123 I]β-CIT) is important for the assessment of disease severity and progression in patients with Parkinson's disease (PD). However, its capability to discriminate between different extrapyramidal disorders has not yet been assessed. The aim of this study was to evaluate the possibility of differentiating patients with PD and with progressive supranuclear palsy (PSP) by means of this method. The distribution of [ 123 I]β-CIT in the basal ganglia was assessed in six normal subjects, 13 petients with PD and five patients with PSP in whom the disease was mild. SPET images were obtained 24±2 h after i.v. injection of the tracer using a brain-dedicated system (CERASPECT). MR and SPET images were co-registered in four normal subjects and used to define a standard set of 16 circular regions of interest (ROIs) on the slice showing the highest striatal activity. The basal ganglia ROIs corresponded to (1) the head of caudate, (2) a region of transition between the head of caudate and the anterior putamen, (3) the anterior putamen and (4) the posterior putamen. A ratio of specific to non-displaceable striatal uptake was calculated normalising the activity of the basal ganglia ROIs to that of the occipital cortex (V3''). ANOVA revealed a global reduction of V3'' in all ROIs of PD and PSP patients compared with normal controls (P 123 I]β-CIT distribution in discrete striatal areas provides information on the relative caudate-putamen damage, with different values being obtained in patients clinically diagnosed as having either PD or PSP. (orig.)

Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts.

Science.gov (United States)

Jablonska, Ewa; Markart, Philipp; Zakrzewicz, Dariusz; Preissner, Klaus T; Wygrecka, Malgorzata

2010-04-09

Coagulation factor XII (FXII) is a liver-derived serine protease involved in fibrinolysis, coagulation, and inflammation. The regulation of FXII expression is largely unknown. Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that has been linked to several pathological processes, including tissue fibrosis by modulating procoagulant and fibrinolytic activities. This study investigated whether TGF-beta1 may regulate FXII expression in human lung fibroblasts. Treatment of human lung fibroblasts with TGF-beta1 resulted in a time-dependent increase in FXII production, activation of p44/42, p38, JNK, and Akt, and phosphorylation and translocation into the nucleus of Smad3. However, TGF-beta1-induced FXII expression was repressed only by the JNK inhibitor and JNK and Smad3 antisense oligonucleotides but not by MEK, p38, or phosphoinositide 3-kinase blockers. JNK inhibition had no effect on TGF-beta1-induced Smad3 phosphorylation, association with Smad4, and its translocation into the nucleus but strongly suppressed Smad3-DNA complex formation. FXII promoter analysis revealed that the -299/+1 region was sufficient for TGF-beta1 to induce FXII expression. Sequence analysis of this region detected a potential Smad-binding element at position -272/-269 (SBE-(-272/-269)). Chromatin immunoprecipitation and streptavidin pulldown assays demonstrated TGF-beta1-dependent Smad3 binding to SBE-(-272/-269). Mutation or deletion of SBE-(-272/-269) substantially reduced TGF-beta1-mediated activation of the FXII promoter. Clinical relevance was demonstrated by elevated FXII levels and its co-localization with fibroblasts in the lungs of patients with acute respiratory distress syndrome. Our results show that JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts and implicate its possible involvement in pathological conditions characterized by elevated TGF-beta1 levels.

No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001-2010.

Science.gov (United States)

Forrester, Joseph D; Kugeler, Kiersten J; Perea, Anna E; Pastula, Daniel M; Mead, Paul S

2015-11-01

Associations between Lyme disease and certain neurodegenerative diseases have been proposed, but supportive evidence for an association is lacking. Similar geographic distributions would be expected if 2 conditions were etiologically linked. Thus, we compared the distribution of Lyme disease cases in the United States with the distributions of deaths due to Alzheimer disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Parkinson disease; no geographic correlations were identified. Lyme disease incidence per US state was not correlated with rates of death due to ALS, MS, or Parkinson disease; however, an inverse correlation was detected between Lyme disease and Alzheimer disease. The absence of a positive correlation between the geographic distribution of Lyme disease and the distribution of deaths due to Alzheimer disease, ALS, MS, and Parkinson disease provides further evidence that Lyme disease is not associated with the development of these neurodegenerative conditions.

Genome-Wide Distribution, Organisation and Functional Characterization of Disease Resistance and Defence Response Genes across Rice Species

Science.gov (United States)

Singh, Sangeeta; Chand, Suresh; Singh, N. K.; Sharma, Tilak Raj

2015-01-01

The resistance (R) genes and defense response (DR) genes have become very important resources for the development of disease resistant cultivars. In the present investigation, genome-wide identification, expression, phylogenetic and synteny analysis was done for R and DR-genes across three species of rice viz: Oryza sativa ssp indica cv 93-11, Oryza sativa ssp japonica and wild rice species, Oryza brachyantha. We used the in silico approach to identify and map 786 R -genes and 167 DR-genes, 672 R-genes and 142 DR-genes, 251 R-genes and 86 DR-genes in the japonica, indica and O. brachyanth a genomes, respectively. Our analysis showed that 60.5% and 55.6% of the R-genes are tandemly repeated within clusters and distributed over all the rice chromosomes in indica and japonica genomes, respectively. The phylogenetic analysis along with motif distribution shows high degree of conservation of R- and DR-genes in clusters. In silico expression analysis of R-genes and DR-genes showed more than 85% were expressed genes showing corresponding EST matches in the databases. This study gave special emphasis on mechanisms of gene evolution and duplication for R and DR genes across species. Analysis of paralogs across rice species indicated 17% and 4.38% R-genes, 29% and 11.63% DR-genes duplication in indica and Oryza brachyantha, as compared to 20% and 26% duplication of R-genes and DR-genes in japonica respectively. We found that during the course of duplication only 9.5% of R- and DR-genes changed their function and rest of the genes have maintained their identity. Syntenic relationship across three genomes inferred that more orthology is shared between indica and japonica genomes as compared to brachyantha genome. Genome wide identification of R-genes and DR-genes in the rice genome will help in allele mining and functional validation of these genes, and to understand molecular mechanism of disease resistance and their evolution in rice and related species. PMID:25902056

Epstein - Barr virus expression in Hodgkin's disease: Correlation withhistologic subtypes and T and B lymphocyte distribution

International Nuclear Information System (INIS)

Mourad, W.; Bazerbashi, S.; Alsohaibani, Mohamed O.; Saddik, M.

1998-01-01

The pathogenesis of Hodgkin's disease is linked to Epstein-Barr virus(EBV). Some histologic subtypes show a high level of viral expression. Theseinclude mixed cellularity (MCHD) and nodular sclerosis (NSHD) subtypes. GradeII NSHD is a more aggressive variant of HD. Lymphocyte predominant (LPHD) isa B cell lymphoproliferative disorder that has not been associated with EBVexpression. Infiltrating lymphocytes in HD are predominantly T lymphocytes,with minor component of B lymphocytes. In the current study, EBV expressionwas tested in cases of HD in relation to histologic subtypes. An attempt wasmade at correlating EBV expression with T and B lymphocyte distribution inlymph nodes involved by HD. Formalin-fixed paraffin-embedded tissue from 62cases of HD were tested for EBV and mRNA expression, using the EBER-1 probeand in situ hybridization. T and B lymphocyte distribution and their ratioswere evaluated using antibodies to T and B lymphocytes (UCHL-1 [CD45RO] andCD20, respectively), and the immunoperoxidase technique. The cases were seenin 38 male and 24 female patients, with an age range of 3 to 72 years (median25 years). There were 30 cases of grade I and 15 cases of grade II NSHD, 9cases of MCHD and 8 cases of LPHD. EBV mRNA expression was seen in 29 cases(46%). This expression was seen in 8 cases of grade I NSHD (26%), 13 cases ofgrade II NSHD (86%) and 8 cases of MCHD (88%). None of the cases of LPHDshowed viral expression. T to B lymphocytes ratios in EBV-positive casesranged from 1/6 to 8/1 and ranged from 2/1 to 20/1 in EBV-negative cases(P=0.06). Nine of the 29 positive cases (31%) showed equal T/B lymphocyteratios (n=4), or predominance of B lymphocytes (n=5). None of theEBV-negative cases showed predominance of B lymphocytes. Our study confirmedpreviously reported findings of the prevalence of EBV expression in MCHD andNSHD. Our findings also suggest that EBV expression may be more commonly seenin aggressive forms of HD. Decreased number of T lymphocytes in

Distribution of Type I Collagen Morphologies in Bone: Relation to Estrogen Depletion

Science.gov (United States)

Wallace, Joseph M.; Erickson, Blake; Les, Clifford M.; Orr, Bradford G.; Holl, Mark M. Banaszak

2009-01-01

Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the ultrastructure of healthy bone precludes us from knowing how disease may impact nanoscale properties in this biological material. Here, we show that quantitative assessments of a distribution of Type I collagen fibril morphologies can be made using atomic force microscopy (AFM). We demonstrate that normal bone contains a distribution of collagen fibril morphologies and that changes in this distribution can be directly related to disease state. Specifically, by monitoring changes in the collagen fibril distribution of sham-operated and estrogen-depleted sheep, we have shown the ability to detect estrogen-deficiency-induced changes in Type I collagen in bone. This discovery provides new insight into the ultrastructure of bone as a tissue and the role of material structure in bone disease. The observation offers the possibility of a much-needed in vitro procedure to complement the current methods used to diagnose osteoporosis and other bone disease. PMID:19932773

Factor XII assay

Science.gov (United States)

... your provider about the meaning of your specific test results. What Abnormal Results ... vary in size so it may be harder to take a blood sample from one person than another. Other slight risks from having ...

Lahkunud 1999

Index Scriptorium Estoniae

2000-01-01

Ilmar Torn (10. I), Leopold Ennosaar (21. I), Voldemar Vaga (23. II), Ilmar Laasi (15. VIII), Voldemar Peil (17. X), Ludvig Kruusmaa (7. XII), Aksel Vallaste (13. XII), Aldo van Eyck (1919-14. I 1999), Bernard Buffet (1928-4. X 1999), Tibor Kalman (1950-5. V 1999).

Hereditary neuromuscular diseases

Energy Technology Data Exchange (ETDEWEB)

Oezsarlak, O. E-mail: ozkan.ozsarlak@uza.be; Schepens, E.; Parizel, P.M.; Goethem, J.W. van; Vanhoenacker, F.; Schepper, A.M. de; Martin, J.J

2001-12-01

This article presents the actual classification of neuromuscular diseases based on present expansion of our knowledge and understanding due to genetic developments. It summarizes the genetic and clinical presentations of each disorder together with CT findings, which we studied in a large group of patients with neuromuscular diseases. The muscular dystrophies as the largest and most common group of hereditary muscle diseases will be highlighted by giving detailed information about the role of CT and MRI in the differential diagnosis. The radiological features of neuromuscular diseases are atrophy, hypertrophy, pseudohypertrophy and fatty infiltration of muscles on a selective basis. Although the patterns and distribution of involvement are characteristic in some of the diseases, the definition of the type of disease based on CT scan only is not always possible.

Eye Disease and Development

DEFF Research Database (Denmark)

Andersen, Thomas Barnebeck; Dalgaard, Carl-Johan Lars; Selaya, Pablo

This research advances the hypothesis that cross-country variation in the historical incidence of eye disease has influenced the current global distribution of per capita income. The theory is that pervasive eye disease diminished the incentive to accumulate skills, thereby delaying the fertility...... transition and the take-off to sustained economic growth. In order to estimate the influence from eye disease incidence empirically, we draw on an important fact from the field of epidemiology: Exposure to solar ultraviolet B radiation (UVB-R) is an underlying determinant of several forms of eye disease...

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.

Science.gov (United States)

Bozdag, Murat; Carta, Fabrizio; Vullo, Daniela; Akdemir, Atilla; Isik, Semra; Lanzi, Cecilia; Scozzafava, Andrea; Masini, Emanuela; Supuran, Claudiu T

2015-05-15

A new series of dithiocarbamates (DTCs) was prepared from primary/secondary amines incorporating amino/hydroxyl-alkyl, mono- and bicyclic aliphatic ring systems based on the quinuclidine, piperidine, hydroxy-/carboxy-/amino-substituted piperidine, morpholine and piperazine scaffolds, and carbon disulfide. The compounds were investigated for the inhibition of four mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) of pharmacologic relevance, that is, the human (h) hCA I, II, IX and XII, drug targets for antiglaucoma (hCA II and XII) or antitumor (hCA IX/XII) agents. The compounds were moderate or inefficient hCA I inhibitors (off-target isoform for both applications), efficiently inhibited hCA II, whereas some of them were low nanomolar/subnanomolar hCA IX/XII inhibitors. One DTC showed excellent intraocular pressure (IOP) lowering properties in an animal model of glaucoma, with a two times better efficiency compared to the clinically used sulfonamide dorzolamide. Copyright © 2015 Elsevier Ltd. All rights reserved.

Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology.

Science.gov (United States)

Brett, Francesca M; Henson, Craig; Staunton, Hugh

2002-03-01

Familial diffuse Lewy body disease (DLBD) is rare and not yet associated with a defect in the synuclein gene. In the differential diagnosis of the parkinsonian syndromes, defects in vertical gaze tend to be identified with progressive supranuclear palsy. False-positive diagnosis of progressive supranuclear palsy can occur, and defects in vertical gaze have been reported in DLBD, although so far a pure vertical gaze palsy associated with pathological abnormalities in the substrate for vertical gaze has not been described. To report the clinical and pathological findings in 2 siblings with DLBD, and to relate the distribution of the pathological abnormalities in the brainstem to centers for vertical gaze. For several years, 2 Irish siblings experienced a progressive parkinsonism-dementia complex associated in one with a defect in vertical gaze and in both with visual hallucinations. In both patients, results of pathological examination revealed (1) Lewy bodies positive for ubiquitin and alpha-synuclein together with cell loss and gliosis in the substantia nigra, locus ceruleus, and neocortex; and (2) similar findings in the rostral interstitial nucleus of the medial longitudinal fasciculus, the posterior commissure, and the interstitial nucleus of Cajal (substrates for vertical gaze). Familial DLBD (not shown to be genetically as distinct from environmentally transmitted) has been shown to exist in an Irish family. Caution should be enjoined in the interpretation of defects in vertical gaze in the differential diagnosis of the parkinsonian syndromes.

Dynamics of epidemic diseases on a growing adaptive network.

Science.gov (United States)

Demirel, Güven; Barter, Edmund; Gross, Thilo

2017-02-10

The study of epidemics on static networks has revealed important effects on disease prevalence of network topological features such as the variance of the degree distribution, i.e. the distribution of the number of neighbors of nodes, and the maximum degree. Here, we analyze an adaptive network where the degree distribution is not independent of epidemics but is shaped through disease-induced dynamics and mortality in a complex interplay. We study the dynamics of a network that grows according to a preferential attachment rule, while nodes are simultaneously removed from the network due to disease-induced mortality. We investigate the prevalence of the disease using individual-based simulations and a heterogeneous node approximation. Our results suggest that in this system in the thermodynamic limit no epidemic thresholds exist, while the interplay between network growth and epidemic spreading leads to exponential networks for any finite rate of infectiousness when the disease persists.

PENGARUH MOTIVASI, PRESTASI BELAJAR, STATUS SOSIAL EKONOMI ORANG TUA DAN LINGKUNGAN TEMAN SEBAYA TERHADAP MINAT MELANJUTKAN PENDIDIKAN KE PERGURUAN TINGGI PADA SISWA KELAS XII KOMPETENSI KEAHLIAN AKUNTANSI DI SMK NEGERI SE-KOTA SEMARANG TAHUN AJARAN 2014/

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Nabila Kharisma

2015-11-01

Full Text Available Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh positif motivasi, prestasi belajar, status sosial ekonomi dan lingkungan teman sebaya terhadap minat melanjutkan pendidikan ke perguruan tinggi pada siswa kelas XII kompetensi keahlian akuntansi di SMK Negeri se-Kota Semarang baik secara simultan maupun parsial. Populasi dalam penelitian ini adalah seluruh siswa kelas XII Kompetensi Keahlian Akuntansi di SMK Negeri se-Kota Semarang tahun ajaran 2014/2015 yang berjumlah 213 siswa. Metode pengambilan sampel menggunakan teknik proportional random sampling dengan jumlah responden sebanyak 135 siswa. Metode pengumpulan data menggunakan angket dan dokumentasi. Sedangkan metode analisis data yang digunakan adalah analisis deskriptif dan pengujian hipotesis menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa terdapat pengaruh motivasi, prestasi belajar, status sosial ekonomi orang tua, dan lingkungan teman sebaya secara simultan berpengaruh sebesar 71,5% terhadap minat melanjutkan pendidikan ke perguruan tinggi. Sedangkan motivasi berpengaruh sebesar 17,47% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial, prestasi belajar berpengaruh sebesar 23,91% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial , status sosial ekonomi orang tua berpengaruh sebesar 16,81% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial, dan lingkungan teman sebaya berpengaruh sebesar 10,50% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial. This research aims to determine the level of positive influence between motivation, academic achievement, socio economic status of parents and peers environment on interest in continuing education to the collage of 12th Accounting Program Students at State Vocational High School of Semarang City in 2014/2015. Populations in this research is students at State Vocational High School of Semarang city specially 12

Filmimaailm / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2010-01-01

Oliver Stone töödest. Charlie Chaplin virtuaalmaailmas. Lähiminevikus lahkunud: inglise-kanada filmiajaloolane ja -kriitik Robin Wood (23. II 1931 - 18. XII 2009), vene filmihelilooja Isaak Švarts (13. V 1923 - 27. XII 2009), prantsuse filmi- ja teatrilavastaja Eric Rohmer (4. IV 1920 - 11. I 2010)

Geographical distribution of myrothecium leaf spot disease of momordica charantial L. caused by myrothecium roridum tode in agro-ecological zone of punjab, Pakistan

International Nuclear Information System (INIS)

Din, G. M.; Farooq, S.; Khan, S. N.; Imani, J.; Naz, S.

2017-01-01

A series of field surveys were carried out during July-October 2012-14 for the development of disease distribution map and updating the index of Myrothecium leaf spot of Momordica charantia (Bitter gourd) in Punjab province. A total of 29 districts were surveyed belonging to 9 sub agro ecological zones of Punjab. The index was calculated on the basis of incidence, prevalence and severity of the disease. The information from stakeholders was gathered through field scouting, formal and informal discussions. Data on socioeconomics was collected by a structured questionnaire. The symptomatic plants and soil specimens were collected form diseased field and transferred to lab for onward studies on host-pathogen characterization and management. Infection development on the plant was investigated on a (0-5) visual severity rating scale. Fungus was isolated, identified on morphological and molecular characteristics as Myrothecium roridum and cultures were deposited to First Fungal Culture Bank of Pakistan (Accession No. FCBP 1155) and Leibniz-institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Germany (Accession No. DSM 28971). Data gathered highlighted dominance of the disease in mixed cropping zone of Punjab province. Highest disease index (31%) was recorded in mixed cropping zone and lowest (3%) in D.G khan zone. However its severity may vary due to adopted cultural and chemical practices by individual farmers. The investigations strengthen the involvement of irrigation technique, soil type and cropping history in introduction and sporadic occurrence of the disease. (author)

Diplomacia, propaganda y guerra santa en el siglo XIV: la embajada castellana a Aviñón y la elaboración del discurso ideológico

Directory of Open Access Journals (Sweden)

Rodríguez-Picavea, Enrique

2010-12-01

Full Text Available After the triumph at the Battle of Salado (1340, Alfonso XI of Castile sent an embassy to Pope Benedict XII to inform him of victory. Naturally, the embassy was conceived as an act of propaganda. This episode was later recounted in the Crónica de Alfonso XI>, the Poema de Alfonso Onceno and the Gran Crónica de Alfonso XI>. The three works produced the ideological discourse that interested to the monarchy. The aim of this paper is to analyze the propaganda transmitted by these three texts. In the story of the embassy to Avignon, Alfonso XI is presented as the leader of Christendom against Islam.

Tras el triunfo en la batalla del Salado (1340, Alfonso XI de Castilla envió una embajada al Papa Benedicto XII para comunicarle la victoria. Naturalmente, la embajada fue concebida como un acto de propaganda política. Este episodio fue recogido posteriormente por las tres fuentes básicas para conocer el reinado del monarca castellano: la Crónica de Alfonso XI>, el Poema de Alfonso Onceno y la Gran Crónica de Alfonso XI>. Las tres obras contribuyeron a elaborar el discurso ideológico que le interesaba transmitir a la monarquía. El objetivo de este trabajo es analizar la visión propagandística que estos textos dejaron sobre el episodio de la embajada a Aviñón, donde el monarca castellano es presentado como el líder que necesita la Cristiandad para enfrentarse al Islam.