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Sample records for disease-a preliminary study

  1. Metabolomics diagnostic approach to mustard airway diseases: a preliminary study

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    BiBi Fatemeh Nobakht Mothlagh Ghoochani

    2018-01-01

    Full Text Available Objective(s: This study aims to evaluate combined proton nuclear magnetic resonance (1H NMR spectroscopy and gas chromatography-mass spectrometry (GC-MS metabolic profiling approaches, for discriminating between mustard airway diseases (MADs and healthy controls and for providing biochemical information on this disease. Materials and Methods: In the present study, analysis of serum samples collected from 17 MAD subjects and 12 healthy controls was performed using NMR. Of these subjects, 14 (8 patients and 6 controls were analyzed by GC-MS. Then, their spectral profiles were subjected to principal component analysis (PCA and orthogonal partial least squares regression discriminant analysis (OPLS-DA. Results: A panel of twenty eight metabolite biomarkers was generated for MADs, sixteen  NMR-derived metabolites (3-methyl-2-oxovaleric acid, 3-hydroxyisobutyrate, lactic acid, lysine, glutamic acid, proline, hydroxyproline, dimethylamine, creatine, citrulline, choline, acetic acid, acetoacetate, cholesterol, alanine, and lipid (mainly VLDL and twelve GC-MS-derived metabolites (threonine, phenylalanine, citric acid, myristic acid, pentadecanoic acid, tyrosine, arachidonic acid, lactic acid, propionic acid, 3-hydroxybutyric acid, linoleic acid, and oleic acid. This composite biomarker panel could effectively discriminate MAD subjects from healthy controls, achieving an area under receiver operating characteristic curve (AUC values of 1 and 0.79 for NMR and GC-MS, respectively. Conclusion: In the present study, a robust panel of twenty-eight biomarkers for detecting MADs was established. This panel is involved in three metabolic pathways including aminoacyl-tRNA biosynthesis, arginine, and proline metabolism, and synthesis and degradation of ketone bodies, and could differentiate MAD subjects from healthy controls with a higher accuracy.

  2. Regenerative therapies for equine degenerative joint disease: a preliminary study.

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    Sarah Broeckx

    Full Text Available Degenerative joint disease (DJD is a major cause of reduced athletic function and retirement in equine performers. For this reason, regenerative therapies for DJD have gained increasing interest. Platelet-rich plasma (PRP and mesenchymal stem cells (MSCs were isolated from a 6-year-old donor horse. MSCs were either used in their native state or after chondrogenic induction. In an initial study, 20 horses with naturally occurring DJD in the fetlock joint were divided in 4 groups and injected with the following: 1 PRP; 2 MSCs; 3 MSCs and PRP; or 4 chondrogenic induced MSCs and PRP. The horses were then evaluated by means of a clinical scoring system after 6 weeks (T1, 12 weeks (T2, 6 months (T3 and 12 months (T4 post injection. In a second study, 30 horses with the same medical background were randomly assigned to one of the two combination therapies and evaluated at T1. The protein expression profile of native MSCs was found to be negative for major histocompatibility (MHC II and p63, low in MHC I and positive for Ki67, collagen type II (Col II and Vimentin. Chondrogenic induction resulted in increased mRNA expression of aggrecan, Col II and cartilage oligomeric matrix protein (COMP as well as in increased protein expression of p63 and glycosaminoglycan, but in decreased protein expression of Ki67. The combined use of PRP and MSCs significantly improved the functionality and sustainability of damaged joints from 6 weeks until 12 months after treatment, compared to PRP treatment alone. The highest short-term clinical evolution scores were obtained with chondrogenic induced MSCs and PRP. This study reports successful in vitro chondrogenic induction of equine MSCs. In vivo application of (induced MSCs together with PRP in horses suffering from DJD in the fetlock joint resulted in a significant clinical improvement until 12 months after treatment.

  3. Paraconsistent artificial neural networks and Alzheimer disease: A preliminary study

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    Jair Minoro Abe

    Full Text Available Abstract EEG visual analysis has proved useful in aiding AD diagnosis, being indicated in some clinical protocols. However, such analysis is subject to the inherent imprecision of equipment, patient movements, electric registers, and individual variability of physician visual analysis. Objectives: To employ the Paraconsistent Artificial Neural Network to ascertain how to determine the degree of certainty of probable dementia diagnosis. Methods: Ten EEG records from patients with probable Alzheimer disease and ten controls were obtained during the awake state at rest. An EEG background between 8 Hz and 12 Hz was considered the normal pattern for patients, allowing a variance of 0.5 Hz. Results: The PANN was capable of accurately recognizing waves belonging to Alpha band with favorable evidence of 0.30 and contrary evidence of 0.19, while for waves not belonging to the Alpha pattern, an average favorable evidence of 0.19 and contrary evidence of 0.32 was obtained, indicating that PANN was efficient in recognizing Alpha waves in 80% of the cases evaluated in this study. Artificial Neural Networks - ANN - are well suited to tackle problems such as prediction and pattern recognition. The aim of this work was to recognize predetermined EEG patterns by using a new class of ANN, namely the Paraconsistent Artificial Neural Network - PANN, which is capable of handling uncertain, inconsistent and paracomplete information. An architecture is presented to serve as an auxiliary method in diagnosing Alzheimer disease. Conclusions: We believe the results show PANN to be a promising tool to handle EEG analysis, bearing in mind two considerations: the growing interest of experts in visual analysis of EEG, and the ability of PANN to deal directly with imprecise, inconsistent, and paracomplete data, thereby providing a valuable quantitative analysis.

  4. Serum Ionized Calcium Quantification for Staging Canine Periodontal Disease: A Preliminary Study.

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    Miguel Carreira, L; Daniela, Dias; Pedro, Azevedo

    2015-06-01

    Periodontal diseases (PD) are infectious, inflammatory, progressive diseases of the oral cavity affecting people and dogs. PD takes 2 forms: gingivitis and periodontitis. Diagnosing or staging PD can be achieved only with dental x-rays and periodontal probing, both of which require the use of general anesthesia in dogs. This study aimed to determine whether serum ionized calcium ([iCa(2+)]) levels can be useful in preliminary PD staging in dogs. A sample of 40 dogs (n = 40) was divided into 4 groups (n = 10 each) based on the following PD stages: G1 (gingivitis), G2 (initial periodontitis), G3 (moderate periodontitis), and G4 (severe periodontitis). The groups were then subjected to [iCa(2+)] quantification. Statistically significant differences were observed between PD stages and [iCa(2+)] for all stages except G3 and G4. Therefore, this parameter can be used as an additional tool to establish and monitor preliminary PD status. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Effects of sensitive electrical stimulation based cueing in Parkinson's disease: a preliminary study

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    Benoît Sijobert

    2016-06-01

    Full Text Available This study aims to investigate the effect of a sensitive cueing on Freezing of Gait (FOG and gait disorders in subjects suffering from Parkinson’s disease (PD. 13 participants with Parkinson’s disease were equipped with an electrical stimulator and a foot mounted inertial measurement unit (IMU. An IMU based algorithm triggered in real time an electrical stimulus applied on the arch of foot at heel off detection. Starting from standing, subjects were asked to walk at their preferred speed on a path comprising 5m straight, u-turn and walk around tasks. Cueing globally decreased the time to achieve the different tasks in all the subjects. In “freezer” subjects, the time to complete the entire path was reduced by 19%. FOG events occurrence was lowered by 12% compared to baseline before and after cueing. This preliminary work showed a positive global effect of an electrical stimulation based cueing on gait and FOG in PD.

  6. Stem Cell Ophthalmology Treatment Study (SCOTS for retinal and optic nerve diseases: a preliminary report

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    Jeffrey N Weiss

    2015-01-01

    Full Text Available In this report, we present the results of a single patient with optic neuropathy treated within the Stem Cell Ophthalmology Treatment Study (SCOTS. SCOTS is an Institutional Review Board approved clinical trial and is the largest ophthalmology stem cell study registered at the National Institutes of Health to date- www.clinicaltrials.gov Identifier NCT 01920867. SCOTS utilizes autologous bone marrow-derived stem cells in the treatment of optic nerve and retinal diseases. Pre- and post-treatment comprehensive eye exams were independently performed at the Wilmer Eye Institute at the Johns Hopkins Hospital, USA. A 27 year old female patient had lost vision approximately 5 years prior to enrollment in SCOTS. Pre-treatment best-corrected visual acuity at the Wilmer Eye Institute was 20/800 Right Eye (OD and 20/4,000 Left Eye (OS. Four months following treatment in SCOTS, the central visual acuity had improved to 20/100 OD and 20/40 OS.

  7. The function and morphology of Meibomian glands in patients with thyroid eye disease: a preliminary study.

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    Wang, Chia-Yu; Ho, Ren-Wen; Fang, Po-Chiung; Yu, Hun-Ju; Chien, Chun-Chih; Hsiao, Chang-Chun; Kuo, Ming-Tse

    2018-04-12

    To investigate function and morphology of the meibomian gland (MG) in patients with thyroid eye disease (TED). In this prospective case series study, patients with unilateral or bilateral TED were consecutively enrolled. The diagnosis of TED was based on the typical orbital findings and/or radiographic evidence. The disease activity of TED was classified according to the clinical activity score (CAS). Degrees of lagophthalmos and exophthalmos, blinking rates, and results of the Schirmer test 1 were also recorded. All patients completed the SPEED questionnaire and underwent MG assessment, including lipid layer thickness (LLT), MG dropout (MGd), and MG expression. In total 31 eyes from 17 patients with unilateral or bilateral TED were included. Patients were divided into inactive TED (CAS 0-1; 20 eyes from 11 patients) and active TED (CAS 2-3, 11 eyes from 6 patients) groups. MGd was significantly more severe in the active TED than the inactive TED group [Median (Inter-quartile region): 3.0 (2.0-3.0) vs. 2.0 (1.0-2.0) degree, P = 0.04]. However, patients with active TED had thicker LLT than those with inactive TED (90.0 [80.0-100.0] vs. 65.0 [47.8-82.5] nm, P = 0.02), and LLT was positively correlated with lagophthalmos (r = 0.37, P = 0.04). Patients with active TED had more severe MGd, but thicker LLT. Active TED may cause periglandular inflammation of MGs, leading to MGd, but compensatory secretion from residual MGs and lagophthalmos-induced forceful blinking might temporarily release more lipids over the tear film.

  8. A selective egocentric topographical working memory deficit in the early stages of Alzheimer's disease: a preliminary study.

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    Bianchini, F; Di Vita, A; Palermo, L; Piccardi, L; Blundo, C; Guariglia, C

    2014-12-01

    The aim of this study was to determine whether an egocentric topographical working memory (WM) deficit is present in the early stages of Alzheimer's disease (AD) with respect to other forms of visuospatial WM. Further, we would investigate whether this deficit could be present in patients having AD without topographical disorientation (TD) signs in everyday life assessed through an informal interview to caregivers. Seven patients with AD and 20 healthy participants performed the Walking Corsi Test and the Corsi Block-Tapping Test. The former test requires memorizing a sequence of places by following a path and the latter is a well-known visuospatial memory task. Patients with AD also performed a verbal WM test to exclude the presence of general WM impairments. Preliminary results suggest that egocentric topographical WM is selectively impaired, with respect to visuospatial and verbal WM, even without TD suggesting an important role of this memory in the early stages of AD. © The Author(s) 2014.

  9. Creativity Assessment in Subjects with Tourette Syndrome vs. Patients with Parkinson’s Disease: A Preliminary Study

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    Carlotta Zanaboni Dina

    2017-07-01

    Full Text Available (1 Background: Literature suggests that high levels of dopamine are associated with creative thoughts. Tourette Syndrome (TS patients have high dopamine levels, while Parkinson’s Disease (PD subjects have low dopamine levels. Consequently, TS individuals are supposed to have a major and PD patients less creative output. Moreover, dopamine medications may alter the level of creativity, and therefore Quality of Life, in both pathologies. (2 Methods: The aim of the study was to verify the hypothesis of TS patients having higher creative scores than PD patients. The assessment consisted of the administration of the Creative Thinking ASK Test. There were 54 participants—36 males and 18 females—i.e., 27 TS patients and 27 PD subjects. Age of the sample was 35 to 57 years old, high school certificate was required. (3 Results: TS sample (103.11 ASK average score was more creative than PD sample (94.11 ASK average score. (4 Conclusions: The results supported the aforementioned hypothesis: TS sample resulted in having higher creative scores than PD sample. Dopamine and other neurotransmitters of TS and PS appear to affect subject’s creativity. Further studies with creative assessments in TS and PD patients are needed to support the preliminary results of our study.

  10. Brain morphometric analysis predicts decline of intelligence quotient in children with sickle cell disease: A preliminary study.

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    Chen, Rong; Krejza, Jaroslaw; Arkuszewski, Michal; Zimmerman, Robert A; Herskovits, Edward H; Melhem, Elias R

    2017-03-01

    For children with sickle cell disease (SCD) and at low risk category of stroke, we aim to build a predictive model to differentiate those with decline of intelligence-quotient (IQ) from counterparts without decline, based on structural magnetic-resonance (MR) imaging volumetric analysis. This preliminary prospective cohort study included 25 children with SCD, homozygous for hemoglobin S, with no history of stroke and transcranial Doppler mean velocities below 170cm/s at baseline. We administered the Kaufman Brief Intelligence Test (K-BIT) to each child at yearly intervals for 2-4 years. Each child underwent MR examination within 30 days of the baseline K-BIT evaluation date. We calculated K-BIT change rates, and used rate of change in K-BIT to classify children into two groups: a decline group and a non-decline group. We then generated predictive models to predict K-BIT decline/non-decline based on regional gray-matter (GM) volumes computed from structural MR images. We identified six structures (the left median cingulate gyrus, the right middle occipital gyrus, the left inferior occipital gyrus, the right fusiform gyrus, the right middle temporal gyrus, the right inferior temporal gyrus) that, when assessed for volume at baseline, are jointly predictive of whether a child would suffer subsequent K-BIT decline. Based on these six regional GM volumes and the baseline K-BIT, we built a prognostic model using the K * algorithm. The accuracy, sensitivity and specificity were 0.84, 0.78 and 0.86, respectively. GM volumetric analysis predicts subsequent IQ decline for children with SCD. Copyright © 2017 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.

  11. The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China.

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    Du, Xing; Wang, Feng; Hu, Zhiwei; Wu, Jimin; Wang, Zhonggao; Yan, Chao; Zhang, Chao; Tang, Juan

    2017-10-17

    None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. Two hundred and fifty patients with symptoms suggestive of GERD and 35 asymptomatic healthy volunteers provided saliva on morning waking, after lunch and dinner for pepsin determination using the Peptest lateral flow device. All patients underwent 24-h multichannel intraluminal impedance pH (24-h MII-pH) monitoring and upper gastrointestinal endoscopy. Based on 24-h MII-pH and endoscopy study, patients were defined as GERD (abnormal MII-pH results and/or reflux esophagitis) and non-GERD otherwise. Patients with GERD had a higher prevalence of pepsin in saliva and higher pepsin concentration than patients with non-GERD and healthy controls (P < 0.001 for all). The pepsin test had a sensitivity of 73% and a specificity of 88.3% for diagnosing GERD using the optimal cut-off value of 76 ng/mL. Postprandial saliva samples collected when the symptoms occurred had a more powerful ability to identify GERD. Salivary pepsin test had moderate diagnostic value for GERD. It may be a promising tool to replace the use of currently invasive tools with advantages of non-invasive, easy to perform and cost effective. ChiCTR-DDD-16009506 (date of registration: October 20, 2016).

  12. Association between micronuclei frequency in pollen mother cells of Tradescantia and mortality due to cancer and cardiovascular diseases: A preliminary study in Sao Jose dos Campos, Brazil

    International Nuclear Information System (INIS)

    Mariani, Rauda Lucia; Martins Jorge, Maria Paulete; Pereira, Sergio Silva; Melione, Luiz Paulo; Carvalho-Oliveira, Regiani; Ma, Te Hsiu; Nascimento Saldiva, Paulo Hilario

    2009-01-01

    The present study was designed to explore the correlation between the frequency of micronuclei in Trad-MN, measured across 28 biomonitoring stations during the period comprised between 11 of May and 2 of October, 2006, and adjusted mortality rates due to cardiovascular, respiratory diseases and cancer in Sao Jose dos Campos, Brazil, an area with different sources of air pollution. For controlling purposes, mortality rate due to gastrointestinal diseases (an event less prone to be affected by air pollution) was also considered in the analysis. Spatial distribution of micronuclei frequency was determined using average interpolation. The association between health estimators and micronuclei frequency was determined by measures of Pearson's correlation. Higher frequencies of micronuclei were detected in areas with high traffic and close to a petrochemical pole. Significant associations were detected between micronuclei frequency and adjusted mortality rate due to cardiovascular diseases (r = 0.841, p = 0.036) and cancer (r = 0.890, p = 0.018). The association between mortality due to chronic obstructive pulmonary diseases was positive but did not reach statistical significance (r = 0.640, p = 0.172), probably because of the small number of events. Gastrointestinal mortality did not exhibit significant association with micronuclei frequency. Because the small number of observations and the nature of an ecological study, the present findings must be considered with caution and considered as preliminary. Further studies, performed in different conditions of contamination and climate should be done before considering Trad-MN in the evaluation of human health risk imposed by air pollutants. - Bioassay used to explore the correlation between air pollution exposition and mortality rates.

  13. Effects of robotic treadmill training on functional mobility, walking capacity, motor symptoms and quality of life in ambulatory patients with Parkinson's disease: a preliminary prospective longitudinal study.

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    Paker, Nurdan; Bugdayci, Derya; Goksenoglu, Goksen; Sen, Aysu; Kesiktas, Nur

    2013-01-01

    preliminary study, robotic treadmill training was useful to improve the functional mobility, walking capacity and motor symptoms in mild to moderate PD. Robotic treadmill training provided a transient improvement in the quality of life during the treatment.

  14. Pattern of subcutaneous fat during follow-up of a cohort of North Indian children with Kawasaki disease: a preliminary study.

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    Suthar, Renu; Singh, Surjit; Bhalla, Anil Kumar; Attri, Savita Verma

    2014-03-01

    Kawasaki disease (KD) has been associated with abnormal lipid profiles. The latter, in turn, have been linked to changes in subcutaneous fat. In this comparative cross-sectional study we have quantified distribution of subcutaneous fat during follow-up of a cohort of North Indian children with KD. We compared 35 KD children (at least 2 years after disease) and 33 healthy controls. Study parameters included weight, height and skinfold thickness (SFT) over biceps, triceps, midaxillary, subscapular, medial calf and suprailiac areas. Waist and hip circumferences were also recorded. All parameters were measured four times at 6-monthly intervals using standardized techniques. Serum lipids were assayed in the study group. Study children were enrolled 3.7 ± 2.5 years after KD and mean age at enrolment was 8.26 ± 3.65 years. Suprailiac SFT measured higher in boys with KD (P ≤ 0.05). Biceps SFT was higher in the study group, but the difference was not significant. Other SFT were not affected. Waist and hip circumference was higher in the study group than controls (P ≤ 0.05). Waist/hip circumference ratio was not affected. Serum low-density lipoprotein cholesterol (LDL-C) and triglycerides were higher in the study group as compared to historical controls (95.60 ± 36.12 and 129.40 ± 64.62 mg/dL vs. 80.10 ± 2.20 and 91.1 ± 29.85; P ≤ 0.05). Total cholesterol and high-density lipoprotein cholesterol levels remained unaffected. Children with KD (especially boys) had increased subcutaneous fat deposition in the suprailiac region and waist, during follow-up. Serum LDL-C and triglycerides were elevated. KD children may have a tendency to develop central obesity. Further studies, with longer follow-up, would be necessary to show whether this has implications for development of coronary artery disease later in life. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  15. Preliminary rail access study

    International Nuclear Information System (INIS)

    1990-01-01

    The Yucca Mountain site, located on the southwestern edge of the Nevada Test Site, is an undeveloped area under investigation as a potential site for nuclear waste disposal by the US Department of Energy. The site currently lacks rail service and an existing rail right-of-way. If the site is suitable and selected for development as a disposal site, rail service is desirable to the Office of Civilian Radioactive Waste Management Program because of the potential of rail to reduce number of shipments and costs relative to highway transportation. This preliminary report is a summary of progress to date for activities to identify and evaluate potential rail options from major rail carriers in the region to the Yucca Mountain site. It is currently anticipated that the rail spur will be operational after the year 2000. 9 refs., 13 figs., 2 tabs

  16. Preliminary nuclear decommissioning cost study

    International Nuclear Information System (INIS)

    Sissingh, R.A.P.

    1981-04-01

    The decommissioning of a nuclear power plant may involve one or more of three possible options: storage with surveillance (SWS), restricted site release (RSR), and unrestricted site use(USU). This preliminary study concentrates on the logistical, technical and cost aspects of decommissioning a multi-unit CANDU generating station using Pickering GS as the reference design. The procedure chosen for evaluation is: i) removal of the fuel and heavy water followed by decontamination prior to placing the station in SWS for thiry years; ii) complete dismantlement to achieve a USU state. The combination of SWS and USU with an interim period of surveillance allows for radioactive decay and hence less occupational exposure in achieving USU. The study excludes the conventional side of the station, assumes waste disposal repositories are available 1600 km away from the station, and uses only presently available technologies. The dismantlement of all systems except the reactor core can be accomplished using Ontario Hydro's current operating, maintenance and construction procedures. The total decommissioning period is spread out over approximately 40 years, with major activities concentrated in the first and last five years. The estimated dose would be approximately 1800 rem. Overall Pickering GS A costs would be $162,000,000 (1980 Canadian dollars)

  17. Potential benefit of a simultaneous, side-by-side display of contrast MDCT and echocardiography over routine sequential imaging for assessment of adult congenital heart disease: A preliminary study.

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    Oe, Hiroki; Watanabe, Nobuhisa; Miyoshi, Toru; Osawa, Kazuhiro; Akagi, Teiji; Kanazawa, Susumu; Ito, Hiroshi

    2018-06-18

    Management of adult congenital heart disease (ACHD) patients requires understanding of its complex morphology and functional features. An innovative imaging technique has been developed to display a virtual multi-planar reconstruction obtained from contrast-enhanced multidetector-computed tomography (MDCT) corresponding to the same cross-sectional image from transthoracic echocardiography (TTE). The aim of this study is to assess the usefulness of this imaging technology in ACHD patients. This study consisted of 46 consecutive patients (30 women; mean age, 52±18 years old) with ACHD who had undergone contrast MDCT. All patients underwent TTE within a week of MDCT. An experienced sonographer who did not know the results of MDCT conducted a diagnosis using TTE and, then, using the new imaging technology. We studied whether this imaging technology provided additional or unexpected findings or makes more accurate diagnosis. In this imaging technology, MDCT cross-section provides higher-resolution image to the deep compared to corresponding TTE image. Depending on the MDCT section which can be arbitrarily set under the echo guide, we can diagnose unexpected or incremental lesions or more accurately assess the severity of the lesion in 27 patients (59%) compared to TTE study alone. This imaging technology was useful in the following situations: CONCLUSIONS: This integrated imaging technology provides incremental role over TTE in complex anatomy, and allows functional information in ACHD patients. Copyright © 2018 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

  18. A composite model including visfatin, tissue polypeptide-specific antigen, hyaluronic acid, and hematological variables for the diagnosis of moderate-to-severe fibrosis in nonalcoholic fatty liver disease: a preliminary study.

    Science.gov (United States)

    Chwist, Alina; Hartleb, Marek; Lekstan, Andrzej; Kukla, Michał; Gutkowski, Krzysztof; Kajor, Maciej

    2014-01-01

    Histopathological risk factors for end-stage liver failure in patients with nonalcoholic fatty liver disease (NAFLD) include nonalcoholic steatohepatitis (NASH) and advanced liver fibrosis. There is a need for noninvasive diagnostic methods for these 2 conditions. The aim of this study was to investigate new laboratory variables with a predictive potential to detect advanced fibrosis (stages 2 and 3) in NAFLD. The study involved 70 patients with histologically proven NAFLD of varied severity. Additional laboratory variables included zonulin, haptoglobin, visfatin, adiponectin, leptin, tissue polypeptide-specific antigen (TPSA), hyaluronic acid, and interleukin 6. Patients with NASH (NAFLD activity score of ≥5) had significantly higher HOMA-IR values and serum levels of visfatin, haptoglobin, and zonulin as compared with those without NASH on histological examination. Advanced fibrosis was found in 16 patients (22.9%) and the risk factors associated with its prevalence were age, the ratio of erythrocyte count to red blood cell distribution width, platelet count, and serum levels of visfatin and TPSA. Based on these variables, we constructed a scoring system that differentiated between NAFLD patients with and without advanced fibrosis with a sensitivity of 75% and specificity of 100% (area under the receiver operating characteristic curve, 0.93). The scoring system based on the above variables allows to predict advanced fibrosis with high sensitivity and specificity. However, its clinical utility should be verified in further studies involving a larger number of patients.

  19. Prader-Willi Disease: A Case Study.

    Science.gov (United States)

    Forbus, William R., III

    A case study focuses on the characteristics and physical management of a 15-year-old with Prader-Willi Syndrome, a birth defect associated with hypotonia, insatiable appetite, hypogonadism, central nervous system dysfunction, and abnormal growth and development . A literature review addresses studies dealing with behavior modification of obesity…

  20. Gastroesophageal Reflux Disease: A Population Based Study

    OpenAIRE

    Nwokediuko, Sylvester

    2009-01-01

    Background The prevalence of gastroesophageal reflux disease varies in different parts of the world. There are no population based studies in Nigeria. The main objectives of this study were to determine the prevalence and risk factors for gastroesophageal reflux disease in a population of Nigerian medical students. Methods The Carlsson-Dent questionnaire was administered to medical students in the clinical phase of their training at the University of Nigeria, Enugu Campus. Some putative risk ...

  1. Schistosoma liver disease; a clinico- pathological study

    International Nuclear Information System (INIS)

    Ali, Suzan Ibrahim

    1996-05-01

    Schistomiasis mansoni infection is a leading cause of severe morbidity in the Sudan. Most of the morbidity and mortality are due to the development of hepatic periportal fibrosis and consequent portal hypertension and bleeding varices. This is a hospital-based, retro-prospective study in the period from 1980-1995. Liver disease (i.e. periportal fibrosis) and its clinical presentation were studied in relation to the degree of fibrosis and other pathological, haematological, and biochemical parameters. The study identified the common hospital presenting symptoms, assessed factors that influence pathogenesis of periportal fibrosis and its severity, as well as, defined criteria which predict those patients who are at risk of bleeding. 898 patients were included. The common presenting symptoms were left hypochondrial pain, haematemesis and enlarged spleen (Towal). Males were found to have an increase prevalence of periportal fibrosis. Splenomegaly was found in almost all patients of the study of different age groups, but spleen size didn't show any significant difference between bleeders and non-bleeders (p=0.28). A sharp rise in the prevalence of bleeding was noted after the age of 16 years. Upper gastrointestinal bleeding was found to be more common

  2. Thiazolidinediones and Parkinson Disease: A Cohort Study.

    Science.gov (United States)

    Connolly, John G; Bykov, Katsiaryna; Gagne, Joshua J

    2015-12-01

    Thiazolidinediones, a class of medications indicated for the treatment of type 2 diabetes mellitus, reduce inflammation and have been shown to provide a therapeutic benefit in animal models of Parkinson disease. We examined the association between treatment with thiazolidinediones and the onset of Parkinson disease in older individuals. We performed a cohort study of 29,397 Medicare patients enrolled in state pharmaceutical benefits programs who initiated treatment with thiazolidinediones or sulfonylureas during the years 1997 through 2005 and had no prior diagnosis of Parkinson disease. New users of thiazolidinediones were propensity score matched to new users of sulfonylureas and followed to determine whether they were diagnosed with Parkinson disease. We used Cox proportional hazards models to compare time to diagnosis of Parkinson disease in the propensity score-matched populations. To assess the association with duration of use, we performed several analyses that required longer continuous use of medications. In the primary analysis, thiazolidinedione users had a hazard ratio for a diagnosis of Parkinson disease of 1.09 (95% confidence interval: 0.71, 1.66) when compared with sulfonylurea users. Increasing the duration-of-use requirements to 10 months did not substantially change the association; the hazard ratios ranged from 1.00 (95% confidence interval: 0.49, 2.05) to 1.17 (95% confidence interval: 0.60, 2.25). Thiazolidinedione use was not associated with a longer time to diagnosis of Parkinson disease than was sulfonylurea use, regardless of duration of exposure. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Semantic Feature Training for the Treatment of Anomia in Alzheimer Disease: A Preliminary Investigation.

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    Flanagan, Kieran J; Copland, David A; van Hees, Sophia; Byrne, Gerard J; Angwin, Anthony J

    2016-03-01

    This is a preliminary investigation into the effectiveness of semantic feature training for the treatment of anomia in Alzheimer disease (AD). Anomia is a common clinical characteristic of AD. It is widely held that anomia in AD is caused by the combination of cognitive deficits and progressive loss of semantic feature information. Therapy that aims to help participants relearn or retain semantic features should, therefore, help treat anomia in AD. Two men with AD and one man with progressive nonfluent aphasia received 10 treatment sessions focused on relearning the names of 20 animals and 20 fruits. Within each category, half of the items were of high and half were of low typicality. We individualized treatment items to each participant, using items that each had not named correctly at baseline. Treatment sessions consisted of naming, category sorting, and semantic feature verification tasks. Both participants with AD showed post-treatment improvements in naming, and one maintained the treatment effects at 6-week follow-up. The semantic category of the treatment items influenced post-treatment outcomes, but typicality did not. In contrast to the participants with AD, the man with progressive nonfluent aphasia had no improvement in naming ability. Our results suggest the potential viability of semantic feature training to treat anomia in AD and, therefore, the need for further research.

  4. Spiral 2: preliminary design study

    International Nuclear Information System (INIS)

    2001-11-01

    The scientific council of GANIL asked to perform a comparative study on the production methods based on gamma induced fission and rapid-neutron induced fission concerning the nature and the intensity of the neutron-rich products. The production rate expected should be around 10 13 fissions per second. The study should include the implantation and the costs of the concerned accelerators. The scientific committee recommended also to study the possibility to re-inject the radioactive beams of SPIRAL-II in the cyclotrons available at GANIL in order to give access to an energy range from 1.7 to 100 MeV/nucleon. For that purpose, some study groups have been formed to evaluate the possibility of such a project in the different components: physics case, target-ion sources, drivers, post-acceleration and general infrastructure. The organization of the project study is given at the end of this report. The following report presents an overview of the study. Particularly the total costs have been assessed according to 3 options for the driver: 38.0*10 6 euros for a 40 MeV deuteron linac, 18.7*10 6 euros for a 45 MeV electron linac, and 29.1*10 6 euros for a 80 MeV deuteron cyclotron

  5. Spiral 2: preliminary design study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-11-15

    The scientific council of GANIL asked to perform a comparative study on the production methods based on gamma induced fission and rapid-neutron induced fission concerning the nature and the intensity of the neutron-rich products. The production rate expected should be around 10{sup 13} fissions per second. The study should include the implantation and the costs of the concerned accelerators. The scientific committee recommended also to study the possibility to re-inject the radioactive beams of SPIRAL-II in the cyclotrons available at GANIL in order to give access to an energy range from 1.7 to 100 MeV/nucleon. For that purpose, some study groups have been formed to evaluate the possibility of such a project in the different components: physics case, target-ion sources, drivers, post-acceleration and general infrastructure. The organization of the project study is given at the end of this report. The following report presents an overview of the study. Particularly the total costs have been assessed according to 3 options for the driver: 38.0*10{sup 6} euros for a 40 MeV deuteron linac, 18.7*10{sup 6} euros for a 45 MeV electron linac, and 29.1*10{sup 6} euros for a 80 MeV deuteron cyclotron.

  6. Preliminary study Malaa. Final report

    International Nuclear Information System (INIS)

    1996-03-01

    Factors of importance for a possible localization of a deep nuclear waste repository at Malaa in northern Sweden are mapped in this study. The geologic structures in the area have been reviewed, mostly from already existing knowledge. Existing infrastructure and necessary improvements are discussed, as well as land use and environment, employment and other social effects. 47 refs, 41 figs, 8 tabs

  7. Doses in mammography. Preliminary study

    International Nuclear Information System (INIS)

    Marquez P, F.; Acosta R, N.; Universidad Nacional Mayor de San Marcos, Lima; Benavente, T.; Universidad Nacional Mayor de San Marcos, Lima; Poma, M.

    2002-01-01

    Mammography is the most important method to detect lesions in the breast with this technique one can detect small tumours before clear clinical symptoms appear. Mammographic image of require high quality standards due that the extremely low contrast between the normal and pathological areas in the breast, eg.g., they have similar attenuation and absorption coefficient. The x-ray mammographic systems, used in this study are Senographe 500t and Senographe DMR, a detector with a RadCal ionization chambers calibrated to the qualities of mammographic x-ray beams, and a breast simulator that is a phantoms of polymethylmethacrylate (PMMA) of several thicknesses with the equivalence of 50% of the glandular tissue. The results obtained indicate that the values of doses at the entrance surface of a breast (DES) are greater the reference value 20 mGy to 5,0 cm of PMMA and the values of the mean glandular dose (MGD) exceed the reference value of 2,1 mGy for 5,1 cm of compressed thick breast. We consider that the values high of the EDS and MGD are due that the x-ray systems no meeting in good condition or for used of x-ray spectra no suitable, so is recommendable be carried out test of quality control to the x-ray systems and also realize studies, or characterize the of x-ray mammographic spectra

  8. River Wyre preliminary feasibility study

    International Nuclear Information System (INIS)

    1991-01-01

    A study undertaken in 1987 for the Department of Energy, of small estuaries and embayments around the coast of the United Kingdom, identified the Wyre as one of the most promising sites for the construction of a small tidal power barrage. Enquiries showed that Organisations with interests in and around the Wyre had carried out extensive surveys and investigations into the physical and environmental aspects of the estuary, many of which would be relevant to the development of a tidal power scheme. It was identified that a barrage constructed on the Wyre, in addition to generating clean renewable energy may also act as a road crossing between Fleetwood and Over Wyre, thereby avoiding the present diversion via the Shard Toll Bridge located some 8km upstream of the town of Fleetwood. (Author)

  9. Lithium isotopic separation: preliminary studies

    International Nuclear Information System (INIS)

    Macedo, Sandra Helena Goulart de

    1998-01-01

    In order to get the separation of natural isotopes of lithium by electrolytic amalgamation, an electrolytic cell with a confined mercury cathode was used to obtain data for the design of a separation stage. The initial work was followed by the design of a moving mercury cathode electrolytic cell and three experiments with six batches stages were performed for the determination of the elementary separation factor. The value obtained, 1.053, was ill agreement: with the specialized literature. It was verified in all experiments that the lithium - 6 isotope concentrated in the amalgam phase and that the lithium - 7 isotope concentrated in the aqueous phase. A stainless-steel cathode for the decomposition of the lithium amalgam and the selective desamalgamation were also studied. In view of the results obtained, a five stages continuous scheme was proposed. (author)

  10. Positive Psychology Interventions for Patients With Heart Disease: A Preliminary Randomized Trial.

    Science.gov (United States)

    Nikrahan, Gholam Reza; Suarez, Laura; Asgari, Karim; Beach, Scott R; Celano, Christopher M; Kalantari, Mehrdad; Abedi, Mohammad Reza; Etesampour, Ali; Abbas, Rezaei; Huffman, Jeff C

    2016-01-01

    Positive psychologic characteristics have been linked to superior cardiac outcomes. Accordingly, in this exploratory study, we assessed positive psychology interventions in patients who had recently undergone a procedure to treat cardiovascular disease. Participants were randomly assigned to receive 1 of 3 different 6-week face-to-face interventions or a wait-list control condition. We assessed intervention feasibility and compared changes in psychologic outcome measures postintervention (7wk) and at follow-up (15wk) between intervention and control participants. Across the interventions, 74% of assigned sessions were completed. When comparing outcomes between interventions and control participants (N = 55 total), there were no between-group differences post-intervention, but at follow-up intervention participants had greater improvements in happiness (β = 14.43, 95% CI: 8.66-20.2, p psychology intervention for cardiac patients. Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

  11. Preliminary study of mercury target structure

    Energy Technology Data Exchange (ETDEWEB)

    Kaminaga, Masanori; Haga, Katsuhiro; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Kumasaka, Katsuyuki; Uchida, Shoji; Nakagawa, Toshi; Mori, Seiji; Nishikawa, Akira

    1997-11-01

    Development of a proton accelerator based neutron source (1.5 GeV, 5.3 mA (for neutron source 3.3 mA), thermal power 8 MW) is currently conducted by the Special Task Force for Neutron Science Initiative, JAERI. Preliminary design studies and related R and D of a solid metal target for the first stage (1.5 GeV, 1 mA) and a liquid metal target for both the first and second stages (1.5 GeV, 3.3 mA) are conducted by the Target Group to develop both solid and liquid metal target systems. A few kinds of target structures have been investigated in FY 1996 and the preliminary results for the target structures are described in this paper. Investigation results of alternative materials for the target container are also described in this paper. (author)

  12. Preliminary summary of the ETF conceptual studies

    Science.gov (United States)

    Seikel, G. R.; Bercaw, R. W.; Pearson, C. V.; Owens, W. R.

    1978-01-01

    Power plant studies have shown the attractiveness of MHD topped steam power plants for baseload utility applications. To realize these advantages, a three-phase development program was initiated. In the first phase, the engineering data and experience were developed for the design and construction of a pilot plant, the Engineering Test Facility (ETF). Results of the ETF studies are reviewed. These three parallel independent studies were conducted by industrial teams led by the AVCO Everett Research Laboratory, the General Electric Corporation, and the Westinghouse Corporation. A preliminary analysis and the status of the critical evaluation of these results are presented.

  13. Preliminary simulation study of doppler reflectometry

    International Nuclear Information System (INIS)

    Ishii, Yuta; Hojo, Hitoshi; Yoshikawa, Masashi; Ichimura, Makoto; Haraguchi, Yusuke; Imai, Tsuyoshi; Mase, Atsushi

    2010-01-01

    A preliminary simulation study of Doppler reflectometry is performed. The simulations solve Maxwell's equations by a finite difference time domain (FDTD) code method in two dimensions. A moving corrugated metal target is used as a plasma cutoff layer to study the basic features of Doppler reflectometry. We examined the effects of the full width at half maximum (FWHM) of the electromagnetic waves and the corrugation depth of the metal target. Furthermore, the effect of a nonuniform plasma is studied using this FDTD analysis. The Doppler shift and velocity are compared with those obtained from FDTD analysis of a uniform plasma. (author)

  14. A preliminary neutron crystallographic study of thaumatin

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Susana C. M. [ILL-EMBL Deuteration Laboratory, Partnership for Structural Biology, 6 Rue Jules Horowitz, 38042 Grenoble (France); Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom); Blakeley, Matthew P. [Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); Leal, Ricardo M. F. [ILL-EMBL Deuteration Laboratory, Partnership for Structural Biology, 6 Rue Jules Horowitz, 38042 Grenoble (France); Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom); ESRF, 6 Rue Jules Horowitz, BP-220, 38043 Grenoble (France); Mitchell, Edward P. [EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom); ESRF, 6 Rue Jules Horowitz, BP-220, 38043 Grenoble (France); Forsyth, V. Trevor, E-mail: tforsyth@ill.fr [ILL-EMBL Deuteration Laboratory, Partnership for Structural Biology, 6 Rue Jules Horowitz, 38042 Grenoble (France); Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom)

    2008-05-01

    Preliminary neutron crystallographic data from the sweet protein thaumatin have been recorded using the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results illustrate the feasibility of a full neutron structural analysis aimed at further understanding the molecular basis of the perception of sweet taste. Such an analysis will exploit the use of perdeuterated thaumatin. A preliminary neutron crystallographic study of the sweet protein thaumatin is presented. Large hydrogenated crystals were prepared in deuterated crystallization buffer using the gel-acupuncture method. Data were collected to a resolution of 2 Å on the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results demonstrate the feasibility of a full neutron crystallographic analysis of this structure aimed at providing relevant information on the location of H atoms, the distribution of charge on the protein surface and localized water in the structure. This information will be of interest for understanding the specificity of thaumatin–receptor interactions and will contribute to further understanding of the molecular mechanisms underlying the perception of taste.

  15. Preliminary study of radium-contaminated soils

    Energy Technology Data Exchange (ETDEWEB)

    Healy, J.W.; Rodgers, J.C.

    1978-10-01

    A preliminary study was made of the potential radiation exposures to people from radium-226 contamination in the soil in order to provide guidance on limits to be applied in decontaminating land. Pathways included were inhalation of radium from resuspension; ingestion of radium with foods; external gamma radiation from radium daughters; inhalation of radon and daughter, both in the open air and in houses; and the intake of /sup 210/Pb and /sup 210/Po from both inhalation and ingestion. The depth of the contaminated layer is of importance for external exposure and especially for radon emanation. The most limiting pathway was found to be emanation of the radon into buildings with limiting values comparable to those found naturally in many areas.

  16. Small hydropower station in Lavin - Preliminary study

    International Nuclear Information System (INIS)

    Merz, F.

    2008-05-01

    This illustrated final report for the Swiss Federal Office of Energy (SFOE) presents the results of a preliminary study regarding a proposed small hydropower installation on the alpine river Lavinuoz in Lavin, Switzerland. The geographical situation with mountains and glaciers in the catchment area of the proposed hydropower installation is discussed as are the appropriate water catchment installations. Possible dangers caused by avalanches and rock fall are examined. The power to be produced - 5,500,000 kWh/y - by the turbine which is nominally rated at 1350 kW is discussed, as are estimates of production costs. Figures on the investments required and the economic feasibility of the project are discussed, as are environmental factors that are to be taken into account.

  17. Preliminary conceptual studies of REX 2000

    International Nuclear Information System (INIS)

    Merchie, F.; Baas, C.; Ballagny, A.; Chagrot, M.; Farny, G.; Barnier, M.; Pattou, A.

    1993-01-01

    Nuclear R and D programs are, to some extent, completely dependent on research reactors availability. In France and others european countries, the major materials testings reactors were built in the sixties and are consequently ageing and reaching the end of their life, some of them having already been shut down. A situation with not a single large research reactor available in first half of next century cannot be imagined, given all the benefits drawn from the use of research reactors. The CEA has therefore started to evaluate the needs for neutron sources in the next four or five decades so as to design the most suitable new facilities to take over from the existing ones. REX 2000 is a new dedicated reactor project intended to meet the needs for fuels and materials testings after the year 2000. The preliminary conceptual studies which have been carried out along the last 18 months are presented and commented. (author)

  18. Preliminary study of radium-contaminated soils

    International Nuclear Information System (INIS)

    Healy, J.W.; Rodgers, J.C.

    1978-10-01

    A preliminary study was made of the potential radiation exposures to people from radium-226 contamination in the soil in order to provide guidance on limits to be applied in decontaminating land. Pathways included were inhalation of radium from resuspension; ingestion of radium with foods; external gamma radiation from radium daughters; inhalation of radon and daughter, both in the open air and in houses; and the intake of 210 Pb and 210 Po from both inhalation and ingestion. The depth of the contaminated layer is of importance for external exposure and especially for radon emanation. The most limiting pathway was found to be emanation of the radon into buildings with limiting values comparable to those found naturally in many areas

  19. Two preliminary studies on sleep and psychotherapy.

    Science.gov (United States)

    Karle, W; Hopper, M; Corriere, R; Hart, J; Switzer, A

    1977-09-01

    Two preliminary studies were conducted to assess the effects of an intensive outpatient psychotherapy, Feeling Therapy, on sleep. This therapy was chosen because of its demonstrated ability to affect its patients' dreams. In the first study a newly entering female patient was recorded across the first three weeks of intensive daily therapy. In contrast to two control subjects recorded across a similar time period, she demonstrated low REM times and short REM latencies on the average, and considerably greater variability in nearly every parameter. In the second study, two patients were recorded across three days (the middle of which was the day of a therapy session) first when new in therapy and then again after two and one-half years of therapy. It was found that when new in therapy both subjects spent nights of significantly altered sleep the day of the therapy session. One subject showed no REM sleep whatsoever while the other showed a 10 min REM latency and low REM time. The significance of these findings and the direction of future research is discussed.

  20. Preliminary studies of the biosynthesis of Austin

    International Nuclear Information System (INIS)

    Wicnienski, N.A.

    1979-01-01

    Aspergillus ustus is one of the most prevalent fungi in the soil. There are now two reports of the occurrence of toxin-producing strains of this fungus on stored foodstuffs. In addition, strains of A. ustus have been isolated along with Penicillium species from samples of South African cheeses. All A. ustus isolates tested were judged to be highly toxic to ducklings when grown on maize meal, however, the toxins involved were not isolated. Austin is the trivial name of one of the toxins made by the fungus found on stored food. Preliminary work to studying the biosynthesis of this compound using 13 C-labeled sodium acetate is reported here. The feasibility of the biosynthetic study was determined by feeding [1- 14 C]-sodium acetate to A. ustus cultures. The assignments made in the 13 C-nmr spectrum of Austin are shown. The lowest dilution factor obtained in [1- 14 C]-sodium acetate feeding experiments was 14. This dilution factor is sufficiently low to allow a successful feeding of [1,2- 13 C 2 ]-sodium acetate. A new metabolite of A. ustus, deacetylaustin, was isolated and identified. An alkaloid of unknown structure was also isolated from the fungus

  1. Preliminary Slope Stability Study Using Slope/ W

    International Nuclear Information System (INIS)

    Nazran Harun; Mohd Abd Wahab Yusof; Kamarudin Samuding; Mohd Muzamil Mohd Hashim; Nurul Fairuz Diyana Bahrudin

    2014-01-01

    Analyzing the stability of earth structures is the oldest type of numerical analysis in geotechnical engineering. Limit equilibrium types of analyses for assessing the stability of earth slopes have been in use in geotechnical engineering for many decades. Modern limit equilibrium software is making it possible to handle ever-increasing complexity within an analysis. It is being considered as the potential method in dealing with complex stratigraphy, highly irregular pore-water pressure conditions, various linear and nonlinear shear strength models and almost any kind of slip surface shape. It allows rapid decision making by providing an early indication of the potential suitability of sites based on slope stability analysis. Hence, a preliminary slope stability study has been developed to improve the capacity of Malaysian Nuclear Agency (Nuclear Malaysia) in assessing potential sites for Borehole Disposal for Disused Sealed Radioactive Sources. The results showed that geometry of cross section A-A ' , B-B ' , C-C ' and D-D ' achieved the factor of safety not less than 1.4 and these are deemed acceptable. (author)

  2. Preliminary experimental studies of waste coal gasification

    Energy Technology Data Exchange (ETDEWEB)

    Su, S.; Jin, Y.G.; Yu, X.X.; Worrall, R. [CSIRO, Brisbane, QLD (Australia). Advanced Coal Technology

    2013-07-01

    Coal mining is one of Australia's most important industries. It was estimated that coal washery rejects from black coal mining was approximately 1.82 billion tonnes from 1960 to 2009 in Australia, and is projected to produce another one billion tonnes by 2018 at the current production rate. To ensure sustainability of the Australian coal industry, we have explored a new potential pathway to create value from the coal waste through production of liquid fuels or power generation using produced syngas from waste coal gasification. Consequently, environmental and community impacts of the solid waste could be minimized. However, the development of an effective waste coal gasification process is a key to the new pathway. An Australian mine site with a large reserve of waste coal was selected for the study, where raw waste coal samples including coarse rejects and tailings were collected. After investigating the initial raw waste coal samples, float/sink testing was conducted to achieve a desired ash target for laboratory-scale steam gasification testing and performance evaluation. The preliminary gasification test results show that carbon conversions of waste coal gradually increase as the reaction proceeds, which indicates that waste coal can be gasified by a steam gasification process. However, the carbon conversion rates are relatively low, only reaching to 20-30%. Furthermore, the reactivity of waste coal samples with a variety of ash contents under N{sub 2}/air atmosphere have been studied by a home-made thermogravimetric analysis (TGA) apparatus that can make the sample reach the reaction temperature instantly.

  3. MALLARD REPRODUCTIVE TESTING IN A POND ENVIRONMENT: A PRELIMINARY STUDY

    Science.gov (United States)

    A 2-year preliminary study was conducted on mallard ducks to determine the feasibility of using outdoor pond enclosures for reproductive studies and to evaluate the effects of the insecticide chlorpyrifos on mallard reproduction. No significant reproductive effects were observed ...

  4. Preliminary study on the dye removal efficacy of immobilized marine ...

    African Journals Online (AJOL)

    Preliminary study on the dye removal efficacy of immobilized marine and freshwater microalgal beads from textile wastewater. SD Kumar, P Santhanam, R Nandakumar, S Anath, B Balaji Prasath, A Shenbaga Devi, S Jeyanthi, T Jayalakshima, P Ananthi ...

  5. Preliminary study on AC superconducting machines

    International Nuclear Information System (INIS)

    Yamamoto, M.; Ishigohka, T.; Shimohka, T.; Mizukami, N.; Yamaguchi, M.

    1988-01-01

    This paper describes the issues involved in developing AC superconducting machines. In the first phase, as a preliminary experiment, a 4kVa AC superconducting coil which employs 100A class 50/60Hz superconductors is made and tested. And, in the second phase, as an extension of the 4kVa coil, a model superconducting transformer is made and examined. The transformer has a novel quench protection system with an auxiliary coil only in the low voltage side. The behavior of the overcurrent protection system is confirmed

  6. Isotope angiocardiography. Method and preliminary own studies

    Energy Technology Data Exchange (ETDEWEB)

    Stepinska, J; Ruzyllo, W; Konieczny, W [Centrum Medyczne Ksztalcenia Podyplomowego, Warsaw (Poland)

    1979-01-01

    Method of technetium isotope 99 m pass through the heart recording with the aid of radioisotope scanner connected with seriograph and computer is being presented. Preliminary tests were carried out in 26 patients with coronary disease without or with previous myocardial infarction, cardiomyopathy, ventricular septal defect and in patients with artificial mitral and aortic valves. The obtained scans were evaluated qualitatively and compared with performed later contrast X-rays of the heart. Size of the right ventricle, volume and rate of left atrial evacuation, size and contractability of left ventricle were evaluated. Similarity of direct and isotope angiocardiographs, non-invasional character and repeatability of isotope angiocardiography advocate its usefulness.

  7. Tritium oxidation and exchange: preliminary studies

    International Nuclear Information System (INIS)

    Phillips, J.E.; Easterly, C.E.

    1978-05-01

    The radiological hazard resulting from an exposure to either tritium oxide or tritium gas is discussed and the factors contributing to the hazard are presented. From the discussion it appears that an exposure to tritium oxide vapor is 10 4 to 10 5 times more hazardous than exposure to tritium gas. Present and future sources of tritium are briefly considered and indicate that most of the tritium has been and is being released as tritium oxide. The likelihood of gaseous releases, however, is expected to increase in the future, calling to task the present general release assumption that 100% of all tritium released is as oxide. Accurate evaluation of the hazards from a gaseous release will require a knowledge of the conversion rate of tritium gas to tritium oxide. An experiment for determining the conversion rate of tritium gas to tritium oxide is presented along with some preliminary data. The conversion rates obtained for low initial concentrations (10 -4 to 10 -1 mCi/ml) indicate the conversion may proceed more rapidly than would be expected from an extrapolation of previous data taken at higher concentrations

  8. Endobronchial Occlusion Stent: A Preliminary Experimental Study

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yo Won; Jeong, Woo Kyoung; Lee, Seoung Hoon; Heo, Jeong Nam; Jeon, Seok Chol [Hanyang University College of Medicine, Seoul (Korea, Republic of); Ko, Gi Young; Song, Ho Young [University of Ulsan College of Medicine, Ulsan (Korea, Republic of)

    2010-04-15

    To evaluate the safety and the technical feasibility of the use of an endobronchial occlusion stent and to get preliminary data for the development of the optimal material required for endobronchial occlusions. A commercialized, self-expandable tracheobronchial stent was modified; one half had a polyurethane cover with an occluded end and the other half was uncovered with a flaring configuration. The occluded end was placed such that it would face the distal lung. Under fluoroscopic guidance, seven stents were placed at the lower lobar bronchus in 6 mini-pigs. The bronchial obstruction was examined immediately after stent placement. Chest radiographs were taken at days 1, 7, 14, and 28 after stent placement and the removed airways from two, two, one, and one mini-pigs sacrificed on corresponding days were examined for the maintenance of bronchial obstruction. Stents were successfully placed and induced the immediate bronchial obstruction in all mini-pigs. Five of seven airways with occlusion stents maintained an obstruction until the mini-pigs were sacrificed. Proximal stent migration occurred in two mini-pigs (29%), and pulmonary consolidations were observed distal to four of the stents (57%). The placement of an endobronchial occlusion stent and the obstruction of targeted bronchi seem to be feasible, but an add-on check valve should be considered to prevent stent migration and obstructive pneumonia

  9. Hamstring tightness and Scheuermann's disease a pilot study.

    Science.gov (United States)

    Fisk, J W; Baigent, M L

    1981-06-01

    The lateral radiographs of the dorsal spines of 20 patients presenting with mainly low back pain are studied. These patients had clinically evident loss of flexion in the low dorsal spine and very tight hamstring muscles. 85% of them showed definite evidence of previous Scheuermann's Disease. The possibility that tight hamstrings may be an important factor in the aetiology of this disease is discussed, and a further large scale study is proposed.

  10. Swallowing in patients with Parkinson's disease: a surface electromyography study.

    Science.gov (United States)

    Ws Coriolano, Maria das Graças; R Belo, Luciana; Carneiro, Danielle; G Asano, Amdore; Al Oliveira, Paulo José; da Silva, Douglas Monteiro; G Lins, Otávio

    2012-12-01

    Our goal was to study deglutition of Parkinson's disease (PD) patients and normal controls (NC) using surface electromyography (sEMG). The study included 15 patients with idiopathic PD and 15 age-matched normal controls. Surface electromyography was collected over the suprahyoid muscle group. Conditions were the following: swallow at once 10 and 20 ml of water and 5 and 10 ml of yogurt of firm consistency, and freely drink 100 ml of water. During swallowing, durations of sEMG were significantly longer in PD patients than in normal controls but no significant differences of amplitudes were found. Eighty percent of the PD patients and 20 % of the NC needed more than one swallow to consume 20 ml of water, while 70 % of the PD patients and none of the NC needed more than one swallow to consume 5 ml of yogurt. PD patients took significantly more time and needed significantly more swallows to drink 100 ml of water than normal controls. We conclude that sEMG might be a simple and useful tool to study and monitor deglutition in PD patients.

  11. Parkinson's disease prevalence in Fabry disease: A survey study

    Directory of Open Access Journals (Sweden)

    Adina H. Wise

    2018-03-01

    Full Text Available Recent research has suggested a possible link between Parkinson's disease (PD and Fabry disease. To test this relationship, we administered a self-report and family history questionnaire to determine the prevalence of PD in Fabry disease patients and family members with likely pathogenic alpha-galactosidase A (GLA mutations. A total of 90 Fabry patients (77 from the online survey and 13 from the Icahn School of Medicine at Mount Sinai (ISMMS were included in the analysis. Two of the Fabry disease patients who completed the online survey were diagnosed with PD (2/90, 2.2%. Among probands older than 60, 8.3% (2/24 were diagnosed with PD. Using Kaplan Meier survival analysis, the age-specific risk of PD by age 70 was 11.1%. Family history was available on 72 Fabry families from the online study and 9 Fabry families from ISMMS. Among these 81 families, 6 (7.4% had one first degree relative who fit the criteria for a conservative diagnosis of PD. The results of this study suggest that there may be an increased risk of developing PD in individuals with GLA mutations, but these findings should be interpreted with caution given the limitations of the study design.

  12. Bradykinesia in Huntington's disease. A prospective, follow-up study.

    Science.gov (United States)

    García Ruiz, Pedro J; Hernández, Jaime; Cantarero, Susana; Bartolomé, Manuel; Sánchez Bernardos, Vicenta; García de Yébenez, Justo

    2002-04-01

    Bradykinesia is a frequent finding in Huntington's disease (HD), but some aspects are presently unknown; including the natural evolution of bradykinesia over time and the correlation between bradykinesia and functional capacity. We studied the motor performance of 20 genetically confirmed patients with HD (age: 40+/-10.8 years; age at onset 33.6+/-11 years; total functional capacity (TFC): 9.57+/-3; UHDRS total motor scale: 31.4+/-13, triplet length (CAG)n: 46.7+/-4 triplets). These patients were studied in baseline conditions and after 18.7+/-6 months of follow-up. In addition, HD patients were compared with 20 age-matched normal controls. Motor study included the four CAPIT timed tests commonly used for Parkinson's disease: pronation-supination (PS), finger dexterity (FD), movement between two points (MTP) and walking test (WT). HD patients were significantly slower than controls in all motor tasks. A significant deterioration occurred over time in three of the four motor tasks (especially FD and WT). A significant correlation between timed tests and TFC score was found (for MTP, r: -0.845; p < 0,0001). In addition a significant correlation between timed tests and the UHDRDS total motor scale was also found (for MTP, r: 0.864; p < 0.0001). In conclusion, simple timed motor tests can detect a deterioration of motor activity over time in HD. Timed tests might be useful to follow the natural evolution of HD and to assess the efficacy of new therapies.

  13. Diet and polycystic kidney disease: A pilot intervention study.

    Science.gov (United States)

    Taylor, Jacob M; Hamilton-Reeves, Jill M; Sullivan, Debra K; Gibson, Cheryl A; Creed, Catherine; Carlson, Susan E; Wesson, Donald E; Grantham, Jared J

    2017-04-01

    Dietary sodium, protein, acid precursors, and water have been linked to cyst growth in polycystic kidney disease; yet, no studies in patients have examined the feasibility of using a dietary intervention that controls all of these factors. The aim of this study was to determine if a diet, appropriate for persons of most ages, reduces the excretion of sodium, urea, acid, and decreases mean urine osmolality while gaining acceptance by patients with autosomal dominant polycystic kidney disease (ADPKD). Twelve adults with ADPKD enrolled in a pre-post pilot feasibility study and served as their own controls. Individuals consumed their usual diet for one week then for four weeks followed an isocaloric diet lower in sodium and protein and higher in fruits, vegetables, and water. Three-day diet records and two 24-h urine samples were collected at baseline, week 2, and week 4 visits; blood pressure, weight, and serum were obtained at all three visits. A modified nutrition hassles questionnaire was completed on the last visit. During the dietary intervention, subjects (n = 11) consumed less sodium, protein, and dietary acid precursors 36%, 28%, and 99%, respectively, and increased fluid intake by 42%. Urinary sodium, urea, net acid excretion, osmoles, and osmolality decreased 20%, 28%, 20%, 37%, and 15%, respectively; volume increased 35%. Urine changes were in accord with the diet record. Ninety-one percent of participants reported that none of the hassles were worse than "somewhat severe", and most participants felt "somewhat confident" or "very confident" that they could manage the new diet. A majority of adult patients with ADPKD successfully prepared and followed a composite diet prescription with decreased sodium, protein, acid precursors, and increased fluid intake. This trail was registered at ClinicalTrials.gov (NCT01810614). Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  14. Infections as risk factor for autoimmune diseases - A nationwide study

    DEFF Research Database (Denmark)

    Nielsen, Philip Rising; Kragstrup, Tue Wenzel; Deleuran, Bent Winding

    2016-01-01

    Viruses, bacteria and other infectious pathogens are the major postulated environmental triggers of autoimmunity. In the present nation-wide study we describe the association between infections and 29 autoimmune diseases. We used the Danish Civil Registration System to identify 4.5 million persons...... to the etiology of autoimmune diseases together with genetic factors....... born between 1945 and 2000. Information on infections and autoimmune diseases was obtained from the Danish Hospital Register. The cohort was followed from 1977 to 2012. Incidence rate ratios for developing an autoimmune disease were estimated using poisson regression. We found an association between...

  15. The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review

    Science.gov (United States)

    Di Piazza, Ambra; Costanzo, Massimo; Scopelliti, Laura; Salvaggi, Francesco; Cupido, Francesco; Salerno, Sergio; Lo Casto, Antonio; Midiri, Massimo; Lo Re, Giuseppe; Lagalla, Roberto

    2017-01-01

    Autoimmune connective tissue diseases are a heterogeneous group of pathologies that affect about 10% of world population with chronic evolution in 20%–80%. Inflammation in autoimmune diseases may lead to serious damage to other organs including the gastrointestinal tract. Gastrointestinal tract involvement in these patients may also due to both a direct action of antibodies against organs and pharmacological therapies. Dysphagia is one of the most important symptom, and it is caused by failure of the swallowing function and may lead to aspiration pneumonia, malnutrition, dehydration, weight loss, and airway obstruction. The videofluorographic swallowing study is a key diagnostic tool in the detection of swallowing disorders, allowing to make an early diagnosis and to reduce the risk of gastrointestinal and pulmonary complications. This technique helps to identify both functional and structural anomalies of the anatomic chain involved in swallowing function. The aim of this review is to systematically analyze the basis of the pathological involvement of the swallowing function for each rheumatological disease and to show the main features of the videofluorographic study that may be encountered in these patients. PMID:28706536

  16. Speech rate in Parkinson's disease: A controlled study.

    Science.gov (United States)

    Martínez-Sánchez, F; Meilán, J J G; Carro, J; Gómez Íñiguez, C; Millian-Morell, L; Pujante Valverde, I M; López-Alburquerque, T; López, D E

    2016-09-01

    Speech disturbances will affect most patients with Parkinson's disease (PD) over the course of the disease. The origin and severity of these symptoms are of clinical and diagnostic interest. To evaluate the clinical pattern of speech impairment in PD patients and identify significant differences in speech rate and articulation compared to control subjects. Speech rate and articulation in a reading task were measured using an automatic analytical method. A total of 39 PD patients in the 'on' state and 45 age-and sex-matched asymptomatic controls participated in the study. None of the patients experienced dyskinesias or motor fluctuations during the test. The patients with PD displayed a significant reduction in speech and articulation rates; there were no significant correlations between the studied speech parameters and patient characteristics such as L-dopa dose, duration of the disorder, age, and UPDRS III scores and Hoehn & Yahr scales. Patients with PD show a characteristic pattern of declining speech rate. These results suggest that in PD, disfluencies are the result of the movement disorder affecting the physiology of speech production systems. Copyright © 2014 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Sodium phenylbutyrate in Huntington's disease: a dose-finding study.

    Science.gov (United States)

    Hogarth, Penelope; Lovrecic, Luca; Krainc, Dimitri

    2007-10-15

    Transcriptional dysregulation in Huntington's disease (HD) is mediated in part by aberrant patterns of histone acetylation. We performed a dose-finding study in human HD of sodium phenylbutyrate (SPB), a histone deacetylase inhibitor that ameliorates the HD phenotype in animal models. We used a dose-escalation/de-escalation design, using prespecified toxicity criteria and standard clinical and laboratory safety measures. The maximum tolerated dose was 15 g/day. At higher doses, toxicity included vomiting, lightheadedness, confusion, and gait instability. We saw no significant laboratory or electrocardiographic abnormalities. Gene expression changes in blood suggested an inverse dose-response. In conclusion, SPB at 12 to 15 g/day appears to be safe and well-tolerated in human HD. 2007 Movement Disorder Society

  18. Pediatric surgical diseases. A radiological surgical case study approach

    International Nuclear Information System (INIS)

    Esposito, Ciro; Esposito, Giovanni

    2009-01-01

    Radiologic evaluation of an infant or child suspected of having a surgical disease can be a complex problem. With this volume, the editors have created a book focused on pediatric imaging written by pediatricians, pediatric surgeons and pediatric radiologists. This book is a collection of over 200 case reports. The concept is a case study approach: The reader is given radiologic images (plain radiography, computed tomography, magnetic resonance imaging, ultrasonography, etc.) and the clinical history of the patient. On the basis of this information, the reader is asked to identify a diagnostic and therapeutic strategy. Each case is complemented by information on the disease affecting the patient and the management of the case shown, including therapy and follow-up. This educational text is targeted at all medical professionals faced with a variety of diagnostic and therapeutic problems affecting infants and children. (orig.)

  19. Pediatric surgical diseases. A radiological surgical case study approach

    Energy Technology Data Exchange (ETDEWEB)

    Esposito, Ciro [Federico II Univ. of Naples (Italy). Chair of Pediatric Surgery; Esposito, Giovanni (eds.) [Federico II Univ. of Naples (Italy). School of Medicine

    2009-07-01

    Radiologic evaluation of an infant or child suspected of having a surgical disease can be a complex problem. With this volume, the editors have created a book focused on pediatric imaging written by pediatricians, pediatric surgeons and pediatric radiologists. This book is a collection of over 200 case reports. The concept is a case study approach: The reader is given radiologic images (plain radiography, computed tomography, magnetic resonance imaging, ultrasonography, etc.) and the clinical history of the patient. On the basis of this information, the reader is asked to identify a diagnostic and therapeutic strategy. Each case is complemented by information on the disease affecting the patient and the management of the case shown, including therapy and follow-up. This educational text is targeted at all medical professionals faced with a variety of diagnostic and therapeutic problems affecting infants and children. (orig.)

  20. Unicuspid aortic valve disease: a magnetic resonance imaging study

    International Nuclear Information System (INIS)

    Debl, K.; Buchner, S.; Heinicke, N.; Riegger, G.; Luchner, A.; Djavidani, B.; Poschenrieder, F.; Feuerbach, S.; Schmid, C.; Kobuch, R.

    2008-01-01

    Purpose: congenitally malformed aortic valves are a common finding in adults with aortic valve disease. Most of these patients have bicuspid aortic valve disease. Unicuspid aortic valve disease (UAV) is rare. The aim of our study was to describe valve morphology and the dimensions of the proximal aorta in a cohort of 12 patients with UAV in comparison to tricuspid aortic valve disease (TAV) using magnetic resonance imaging (MRI). Materials and methods/results: MRI studies were performed on a 1.5 T scanner in a total of 288 consecutive patients with aortic valve disease. 12 aortic valves were retrospectively classified as UAV. Annulus areas and dimensions of the thoracic aorta were retrospectively compared to a cohort of 103 patients with TAV. In UAV, valve morphology was unicuspid unicommissural with a posterior commissure in all patients. Mean annulus areas and mean diameters of the ascending aorta were significantly greater in UAV compared to TAV (12.6 ± 4.7 cm 2 vs. 8.7 ± 2.3 cm 2 , p < 0.01 and 4.6 ± 0.7 cm vs. 3.6 ± 0.5 cm, p < 0.0001, respectively), while no differences were observed in the mean diameters of the aortic arch (2.3 ± 0.6 cm vs. 2.3 ± 0.4 cm, p = 0.69). The diameters of the descending aorta were slightly smaller in UAV compared to TAV (2.2 ± 0.5 cm vs. 2.6 ± 0.3 cm, p < 0.05). (orig.)

  1. Unicuspid aortic valve disease: a magnetic resonance imaging study

    Energy Technology Data Exchange (ETDEWEB)

    Debl, K.; Buchner, S.; Heinicke, N.; Riegger, G.; Luchner, A. [Klinik und Poliklinik fuer Innere Medizin II, Universitaetsklinikum Regensburg (Germany); Djavidani, B.; Poschenrieder, F.; Feuerbach, S. [Inst. fuer Roentgendiagnostik, Universitaetsklinikum Regensburg (Germany); Schmid, C.; Kobuch, R. [Klinik und Poliklinik fuer Herz-, Thorax- und herznahe Gefaesschirurgie, Universitaetsklinikum Regensburg (Germany)

    2008-11-15

    Purpose: congenitally malformed aortic valves are a common finding in adults with aortic valve disease. Most of these patients have bicuspid aortic valve disease. Unicuspid aortic valve disease (UAV) is rare. The aim of our study was to describe valve morphology and the dimensions of the proximal aorta in a cohort of 12 patients with UAV in comparison to tricuspid aortic valve disease (TAV) using magnetic resonance imaging (MRI). Materials and methods/results: MRI studies were performed on a 1.5 T scanner in a total of 288 consecutive patients with aortic valve disease. 12 aortic valves were retrospectively classified as UAV. Annulus areas and dimensions of the thoracic aorta were retrospectively compared to a cohort of 103 patients with TAV. In UAV, valve morphology was unicuspid unicommissural with a posterior commissure in all patients. Mean annulus areas and mean diameters of the ascending aorta were significantly greater in UAV compared to TAV (12.6 {+-} 4.7 cm{sup 2} vs. 8.7 {+-} 2.3 cm{sup 2}, p < 0.01 and 4.6 {+-} 0.7 cm vs. 3.6 {+-} 0.5 cm, p < 0.0001, respectively), while no differences were observed in the mean diameters of the aortic arch (2.3 {+-} 0.6 cm vs. 2.3 {+-} 0.4 cm, p = 0.69). The diameters of the descending aorta were slightly smaller in UAV compared to TAV (2.2 {+-} 0.5 cm vs. 2.6 {+-} 0.3 cm, p < 0.05). (orig.)

  2. The Gestational Trophoblastic Diseases: A Ten Year Retrospective Study

    Directory of Open Access Journals (Sweden)

    Razieh Mohammadjafari

    2010-01-01

    Full Text Available Background: Gestational trophoblastic disease (GTD defines a heterogenenous group ofinterrelated lesions that arise from the trophoblastic epithelium of the placenta. There are severalhistologically distinct types of GTD: hydatiform mole (complete or partial, persistant/invasivegestational trophoblastic neoplasia (GTN, choriocarcinoma and placenta site trophoblastictumors. The aim of this study was to determine the frequency and risk factors of GTD amongwomen admitted to Imam Khomeini Hospital in Ahvaz, Iran.Materials and Methods: This was a cross-sectional study conducted at Imam KhomeiniHospital in Ahvaz, Iran. All hospital records related to GTD (132 from 1996 until 2006 werereviewed. Demographic and histo-pathologic characteristics were extracted. Chi-square andFisher-exact tests were used to analyze all variables. P ≤ 0.05 was considered statisticallysignificant. SPSS, version 11 was used for statistical analysis.Results: The mean age of patients was 27.6 years. Most patients who presented with GTDwere of ages 18-35 years (71.3%. There was no relationship between age and hydatiformmole during the reproductive years. There were 28 (18.9% patients over the age 40, of which18 (15.90% of these had a complete hydatiform mole. Within this group, 9 (6.8% changedto a persistent mole. There was a significant relationship between age over 40 and completemole (p<0.02. The percentage of patients with blood groups A and O was the same (37.9%.There was a significant relationship between blood groups (O+ and A+ and complete mole(p<0.05.Conclusion: The most common age range for hydatiform mole was 18-35 years. Women overthe age of 40 had a more complete hydatiform mole, which is similar to the other countries.Age and blood group are two risk factors for hydatiform mole.

  3. Divorce and Severity of Coronary Artery Disease: A Multicenter Study

    Directory of Open Access Journals (Sweden)

    Amin Daoulah

    2017-01-01

    Full Text Available The association between marital status and coronary artery disease (CAD is supported by numerous epidemiological studies. While divorce may have an adverse effect on cardiac outcomes, the relationship between divorce and severe CAD is unclear. We conducted a multicenter, observational study of consecutive patients undergoing coronary angiography during the period between April 1, 2013, and March 30, 2014. Of 1,068 patients, 124 (12% were divorced. Divorce was more frequent among women (27% compared to men (6%. Most divorced patients had been divorced only once (49%, but a subset had been divorced 2 (38% or ≥3 (12% times. After adjusting for baseline differences, there was no significant association between divorce and severe CAD in men. In women, there was a significant adjusted association between divorce and severe MVD (OR 2.31 [1.16, 4.59] or LMD (OR 5.91 [2.19, 15.99]. The modification of the association between divorce and severe CAD by gender was statistically significant for severe LMD (Pinteraction 0.0008 and marginally significant for CAD (Pinteraction 0.05. Among women, there was a significant adjusted association between number of divorces and severe CAD (OR 2.4 [95% CI 1.2, 4.5], MVD (OR 2.0 [95% CI 1.4, 3.0], and LMD (OR 3.4 [95% CI 1.9, 5.9]. In conclusion, divorce, particularly multiple divorces, is associated with severe CAD, MVD, and LMD in women but not in men.

  4. Pulpal changes associated with advanced periodontal disease: A histopathological study.

    Science.gov (United States)

    Gautam, Siddharth; Galgali, Sushama R; Sheethal, H S; Priya, N S

    2017-01-01

    Over the past century, the dental literature has consistently reflected a controversy related to the effect of periodontal disease on the dental pulp. Nonetheless, practitioners are of the opinion that teeth having deep periodontal pockets show variable pulpal response, which may necessitate root canal treatment. Thus, this study aimed to evaluate the changes in pulp due to advanced periodontal disease. Forty caries-free teeth affected with severe periodontitis were collected from patients aged between 18 and 55 years. The collected teeth were stored in formalin for 24 h and were then decalcified and examined histologically after staining with hematoxylin and eosin to note the changes that occurred in pulp. Pulpal calcification (52.62%) and partial necrosis of pulp (52.62%) were found to be the most common findings. Inflammation, which was found in 47.38% of the cases, ranged from mild to severe in most sections and was always chronic. Pulp with complete necrosis was seen in 26.32% of cases. Fibrosis and pulpal edema were seen in 36.84% of cases. In the presence of moderate to severe chronic periodontitis, degenerative changes such as inflammation, fibrosis, edema, calcification and necrosis were observed to variable degree.

  5. Amino acid-responsive Crohn's disease: a case study

    Directory of Open Access Journals (Sweden)

    Alvin Stein

    2010-12-01

    Full Text Available Alvin Stein1, Marty Hinz2, Thomas Uncini31Stein Orthopedic Associates, Plantation, FL, USA; 2Clinical Research, NeuroResearch Clinics Inc., Cape Coral, FL, USA; 3Laboratory, Fairview Regional Medical Center-Mesabi, Hibbing, MN, USAPurpose: This paper reviews the clinical course of a case of severe Crohn's disease and discusses the scientific ramifications of a novel treatment approach.Patients and methods: A case study of a 37-year-old male with a 22-year history of Crohn's disease whose clinical course had experienced no sustained remissions. The patient was treated with a protocol that utilized serotonin and dopamine amino acid precursors administered under the guidance of organic cation transporter assay interpretation.Results: Within 5 days of achieving the necessary balance of serotonin and dopamine, the patient experienced remission of symptoms. This remission has been sustained without the use of any Crohn's disease medications.Conclusion: In Crohn's disease, it is known that there is an increase of both synthesis and tissue levels of serotonin in specific locations. It is asserted that this is prima facie evidence of a significant imbalance in the serotonin–dopamine system, leading to serotonin toxicity. The hypothesis formulated is that improperly balanced serotonin and dopamine transport, synthesis, and metabolism is a primary defect contributing to the pathogenesis of Crohn's disease.Keywords: serotonin, dopamine, organic cation transporters, OCT

  6. Cognitive training in Alzheimer's disease: a controlled randomized study.

    Science.gov (United States)

    Giovagnoli, A R; Manfredi, V; Parente, A; Schifano, L; Oliveri, S; Avanzini, G

    2017-08-01

    This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer's disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships. At the end of the CT, initiative significantly improved, whereas, at the end of AMT and NE, it was unchanged. Episodic memory showed no changes at the end of CT or AMT and a worsening after NE. The rates of the patients with clinically significant improvement of initiative were greater after CT (about 62%) than after AMT (about 8%) or NE (none). At the 3-month follow-up, initiative and episodic memory declined in all patients. Mood and social relationships improved in the three groups, with greater changes after AMT or NE. In patients with mild to moderate AD, CT can improve initiative and stabilize memory, while the non-cognitive treatments can ameliorate the psychosocial aspects. The combining of CT and non-cognitive treatments may have useful clinical implications.

  7. Depression in Parkinson's disease: A case-control study.

    Directory of Open Access Journals (Sweden)

    Yu-Hsuan Wu

    Full Text Available To evaluate the association between Parkinson's disease (PD prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia. The association between the onset of depression and levodopa equivalent dosage (LED and cumulative equivalent dosage of antidepressants were assessed.PD patients with post-diagnostic depression were associated with significantly higher risks of dementia (adjusted HR = 2·01, p = 0·015, and were older (58·5 ± 17·7 vs. 53·7 ± 18·6, p = 0·020 at the time of PD diagnosis than PD patients with pre-diagnostic depression. The higher incident rate of accidental injury was also noted in PD patients with post-diagnostic depression (48·1 vs. 31·3/1000 person-years, HR = 1·60, p = 0·041, but no statistical significance was observed in the adjusted hazard ratio (HR (HR = 1·52, p = 0·069. Otherwise, mortality, motor condition and severity of depression revealed no significant difference between PD patients with pre-diagnostic and post-diagnostic depression.PD patients with post-diagnostic depression had higher incidence of dementia, implying different onset time of depression could be associated with different subtypes and spreading routes which should be examined in follow-up studies.

  8. Comorbidities in rotator cuff disease: a case-control study.

    Science.gov (United States)

    Titchener, Andrew G; White, Jonathan J E; Hinchliffe, Sally R; Tambe, Amol A; Hubbard, Richard B; Clark, David I

    2014-09-01

    Rotator cuff disease is a common condition in the general population, but relatively little is known about its associated risk factors. We have undertaken a large case-control study using The Health Improvement Network database to assess and to quantify the relative contributions of some constitutional and environmental risk factors for rotator cuff disease in the community. Our data set included 5000 patients with rotator cuff disease who were individually matched with a single control by age, sex, and general practice (primary care practice). The median age at diagnosis was 55 years (interquartile range, 44-65 years). Multivariate analysis showed that the risk factors associated with rotator cuff disease were Achilles tendinitis (odds ratio [OR] = 1.78), trigger finger (OR = 1.99), lateral epicondylitis (OR = 1.71), and carpal tunnel syndrome (OR = 1.55). Oral corticosteroid therapy (OR = 2.03), oral antidiabetic use (OR = 1.66), insulin use (OR = 1.77), and "overweight" body mass index of 25.1 to 30 (OR = 1.15) were also significantly associated. Current or previous smoking history, body mass index of greater than 30, any alcohol intake, medial epicondylitis, de Quervain syndrome, cubital tunnel syndrome, and rheumatoid arthritis were not found to be associated with rotator cuff disease. We have identified a number of comorbidities and risk factors for rotator cuff disease. These include lateral epicondylitis, carpal tunnel syndrome, trigger finger, Achilles tendinitis, oral corticosteroid use, and diabetes mellitus. The findings should alert the clinician to comorbid pathologic processes and guide future research into the etiology of this condition. Copyright © 2014 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  9. Suicide and chronic kidney disease: a case-control study.

    Science.gov (United States)

    Liu, Chao-Han; Yeh, Ming-Kung; Weng, Shu-Chuan; Bai, Meng-Yi; Chang, Jung-Chen

    2017-09-01

    The association of chronic kidney disease (CKD) and dialysis with suicide is not well established. The objectives of this study were to assess the association of suicide with CKD and dialysis and investigate whether differences exist between dialysis modalities or the durations of dialysis. Data were obtained from the Taiwan National Health Insurance Research Database. A total of 51 642 patients who died from suicide between 2000 and 2012 and 206 568 living control patients matched by age, gender and residency area were examined. Known risk factors included sociodemographic characteristics, physical comorbidities and psychiatric disorders, which were controlled for as covariates in the analysis. The crude odds ratios (ORs) and adjusted ORs (aORs) for various risk factors were obtained using conditional logistic regression. After potential confounders were controlled for, CKD was significantly associated with an increased risk of suicide [aOR = 1.25, 95% confidence interval (CI) = 1.17-1.34]. End-stage renal disease patients on haemodialysis (HD) had an increased risk of suicide compared with controls (aOR = 3.35, 95% CI = 3.02-3.72). Moreover, patients who initially underwent dialysis within 0-3 months had a significantly increased risk of suicide (aOR = 20.26, 95% CI = 15.99-25.67). CKD and HD are positively associated with suicide. Suicide is preventable; therefore, assessing mental and physical disorders is essential and recommended to all physicians, particularly those treating patients in the early phase of HD. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  10. Birth weight, sex, and celiac disease: a nationwide twin study

    Directory of Open Access Journals (Sweden)

    Kuja-Halkola R

    2017-11-01

    =1.11–2.02. However, the association was not significant in within-pair analyses for both dizygotic and monozygotic twins and for both sexes.Conclusion: This population-based study found that in male twins, higher birth weight was associated with higher risk of CD. However, when comparing discordant twin pairs in within-twin pair analyses, there was no statistically significant association between birth weight, intrauterine growth, and future risk of CD. Keywords: autoimmune, gestational age, gluten, registries, risk factors, twins

  11. Global economic consequences of selected surgical diseases: a modelling study.

    Science.gov (United States)

    Alkire, Blake C; Shrime, Mark G; Dare, Anna J; Vincent, Jeffrey R; Meara, John G

    2015-04-27

    The surgical burden of disease is substantial, but little is known about the associated economic consequences. We estimate the global macroeconomic impact of the surgical burden of disease due to injury, neoplasm, digestive diseases, and maternal and neonatal disorders from two distinct economic perspectives. We obtained mortality rate estimates for each disease for the years 2000 and 2010 from the Institute of Health Metrics and Evaluation Global Burden of Disease 2010 study, and estimates of the proportion of the burden of the selected diseases that is surgical from a paper by Shrime and colleagues. We first used the value of lost output (VLO) approach, based on the WHO's Projecting the Economic Cost of Ill-Health (EPIC) model, to project annual market economy losses due to these surgical diseases during 2015-30. EPIC attempts to model how disease affects a country's projected labour force and capital stock, which in turn are related to losses in economic output, or gross domestic product (GDP). We then used the value of lost welfare (VLW) approach, which is conceptually based on the value of a statistical life and is inclusive of non-market losses, to estimate the present value of long-run welfare losses resulting from mortality and short-run welfare losses resulting from morbidity incurred during 2010. Sensitivity analyses were performed for both approaches. During 2015-30, the VLO approach projected that surgical conditions would result in losses of 1·25% of potential GDP, or $20·7 trillion (2010 US$, purchasing power parity) in the 128 countries with data available. When expressed as a proportion of potential GDP, annual GDP losses were greatest in low-income and middle-income countries, with up to a 2·5% loss in output by 2030. When total welfare losses are assessed (VLW), the present value of economic losses is estimated to be equivalent to 17% of 2010 GDP, or $14·5 trillion in the 175 countries assessed with this approach. Neoplasm and injury account

  12. Spirituality and the Events of September 11: A Preliminary Study

    Science.gov (United States)

    Briggs, Michele Kielty; Apple, Kevin J.; Aydlett, Ann E.

    2004-01-01

    Personal crises have been associated with spiritual growth. Sparked by the global response to the crisis of September 11, 2001, this study examined the relationship of spirituality and the September 11 tragedy using a sample of convenience from a college student population. This preliminary study used an experimental design to examine various…

  13. A New Silver Complex with Ofloxacin – Preliminary Study

    Directory of Open Access Journals (Sweden)

    Rusu Aura

    2016-06-01

    Full Text Available Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin.

  14. Oxygenates in automotive fuels. Consequence analysis - preliminary study

    International Nuclear Information System (INIS)

    Brandberg, Aa.; Saevbark, B.

    1994-01-01

    Oxygenates is used in gasoline due to several reasons. They are added as high-octane components in unleaded gasoline and as agents to reduce the emission of harmful substances. Oxygenates produced from biomass might constitute a coming market for alternative fuels. This preliminary study describes the prerequisites and consequences of such an oxygenate utilization. 39 refs, 9 figs, 5 tabs

  15. A preliminary study on the relevancy of sustainable building design ...

    African Journals Online (AJOL)

    This preliminary study aims to explore the relationship between sustainable building design paradigms and commercial property depreciation, to assist in the understanding of sustainable building design impact towards commercial building value and rental de employs the qualitative method and analyses valuers' current ...

  16. A Preliminary Study toward Consistent Soil Moisture from AMSR2

    NARCIS (Netherlands)

    Parinussa, R.M.; Holmes, T.R.H.; Wanders, N.; Dorigo, W.A.; de Jeu, R.A.M.

    2015-01-01

    A preliminary study toward consistent soil moisture products from the Advanced Microwave Scanning Radiometer 2 (AMSR2) is presented. Its predecessor, the Advanced Microwave Scanning Radiometer for Earth Observing System (AMSR-E), has providedEarth scientists with a consistent and continuous global

  17. PTSD and Impaired Eye Expression Recognition: A Preliminary Study

    Science.gov (United States)

    Schmidt, Jakob Zeuthen; Zachariae, Robert

    2009-01-01

    This preliminary study examined whether posttraumatic stress disorder (PTSD) was related to difficulties in identifying the mental states of others in a group of refugees. Sixteen Bosnian refugees, referred to treatment in an outpatient treatment center for survivors of torture and war-related trauma in Denmark (CETT), were compared to 16 non-PTSD…

  18. Preliminary study and Identification of insects' species of forensic ...

    African Journals Online (AJOL)

    The proper identification of the insect and arthropod species of forensic importance is the most crucial element in the field of forensic entomology. The main objective in this study was the identification of insects' species of forensic importance in Urmia (37°, 33 N. and 45°, 4, 45 E.) and establishment of a preliminary ...

  19. Preliminary study on chicken feather protein-based wood adhesives

    Science.gov (United States)

    Zehui Jiang; Daochun Qin; Chung-Yun Hse; Monlin Kuo; Zhaohui Luo; Ge Wang; Yan Yu

    2008-01-01

    The objective of this preliminary study was to partially replace phenol in the synthesis of phenol-formaldehyde resin with feather protein. Feather protein–based resins, which contained one part feather protein and two parts phenol, were formulated under the conditions of two feather protein hydrolysis methods (with and without presence of phenol during...

  20. A preliminary study on growth response of broiler finishers fed ...

    African Journals Online (AJOL)

    A preliminary study on growth response of broiler finishers fed processed mottle Mucuna beans ( Mucuna pruriens var. utilis ) ... They were fed diets (20% CP, 13 MJME/kg) incorporating 0%, 5% and 10% processed mottle “Mucuna” beans. A completely randomized design was used. Feed and water were supplied and ...

  1. Preliminary study of pur-revetment's application

    NARCIS (Netherlands)

    Gu, D.; Verhagen, H.J.; Van de Ven, M.

    2008-01-01

    PUR-revetment is a newly developed method for hydraulic application. Its structure is similar to that of open stone asphalt revetment, but the crushed stones are glued by polyurethane (PUR) instead of bitumen. To study the feasibility of applying PUR-revetment, a research based on the comparisons

  2. Diesel engine emission deterioration - a preliminary study

    CSIR Research Space (South Africa)

    Pretorius, Cecilia J

    2016-04-01

    Full Text Available The objective of this study was to find a parameter in diesel and oil analysis of underground mining vehicles that can be correlated with personal diesel particulate matter (DPM) exposure and used as part of an engine maintenance programme. A number...

  3. Preliminary study of some problems in deconvolution

    International Nuclear Information System (INIS)

    Gilly, Louis; Garderet, Philippe; Lecomte, Alain; Max, Jacques

    1975-07-01

    After defining convolution operator, its physical meaning and principal properties are given. Several deconvolution methods are analysed: method of Fourier Transform and iterative numerical methods. Positivity of measured magnitude has been object of a new Yvon Biraud's method. Analytic prolongation of Fourier transform applied to unknow fonction, has been studied by M. Jean-Paul Sheidecker. An important bibliography is given [fr

  4. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume of the Systems Design Study contain four Appendixes that were part of the study. Appendix A is an EG ampersand G Idaho, Inc., report that represents a review and compilation of previous reports describing the wastes and quantities disposed in the Subsurface Disposal Area of the Idaho National Engineering Laboratory. Appendix B contains the process flowsheets considered in this study, but not selected for detailed analysis. Appendix C is a historical tabulation of radioactive waste incinerators. Appendix D lists Department of Energy facilities where cementation stabilization systems have been used

  5. Combustion synthesis and preliminary luminescence studies of ...

    Indian Academy of Sciences (India)

    The polycrystalline sample of LiBaPO4 : Tb3+ (LBPT) was successfully synthesized by solution combustion synthesis and studied for its luminescence characteristics. The thermoluminescence (TL) glow curve of LBPT material consists of two peaks at 204.54 and 251.21°C. The optimum concentration was 0.005 mol to ...

  6. Preliminary simulation studies of accelerator cavity loading

    International Nuclear Information System (INIS)

    Faehl, R.J.

    1980-06-01

    Two-dimensional simulations of loading effects in a 350 MHz accelerator cavity have been performed. Electron currents of 1-10 kA have been accelerated in 5 MV/m fields. Higher order cavity modes induced by the beam may lead to emittance growth. Operation in an autoaccelerator mode has been studied

  7. Preliminary study of possible ORELA replacement options

    International Nuclear Information System (INIS)

    Olsen, D.K.; Martin, J.A.; Horen, D.J.

    1984-06-01

    Based on two conceptual design studies performed by the LANL Accelerator Technology Division, the possibilities in terms of accelerator systems for replacing ORELA with a more intense Maxwellian-type continuous-energy neutron source are summarized and discussed. The neutron intensities from ORELA are compared with those from existing or potential accelerator systems used for cross-section and condensed-matter studies. The best replacement options seem to involve a spallation source from 200- to 400-MeV protons on an ORELA-like target. Pulsing and intensity desiderata with such a source are discussed which correspond to a spectrum-averaged 100-fold improved figure of merit over ORELA for TOF measurements with only a tenfold increased source strength. Existing accelerator designs seem to be inadequate for such a source. Consequently, two conceptual designs were developed for this study by the LANL Accelerator Technology Division. The first conceptual design is for a 200-MeV large linac capable of accelerating 1.3 A during a macropulse; this linac standing alone could serve as an ORELA replacement source. The second conceptual design is for a much smaller 250-MeV PIGMI linac with a 28-mA macropulse current which feeds a proton accumulator ring and bunch-compressor transport line. This linac-ring-compressor (LIRIC) option would give a more cost-effective neutron source for cross-section measurements, whereas the large linac, or a modified version of it, would give a much simpler system more suitable for expansion. In particular, both conceptual designs would incorporate the present ORELA building and would provide approximately 100-fold improved neutron sources over ORELA for cross-section measurements. The total estimated cost of the LIRIC system would be $43M (1984), whereas the cost of the large linac would be about a factor of two more. 55 references, 11 figures, 19 tables

  8. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1991-09-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept

  9. Epidemiological studies of radiation workers: preliminary communication

    International Nuclear Information System (INIS)

    Schofield, G.B.

    1982-01-01

    British Nuclear Fuels Limited has embarked on a study of the mortality data among those of its workforce who were employed prior to 1 January 1976. The study covers a total population of about 41000 current and ex-employees, but is initially concerned with a radiation worker cohort of 7500 at the Sellafield establishment where the highest radiation doses are received. Tracing of the health status of ex-employees has been undertaken using the services provided by the Office of Population Censuses and Surveys (OPCS) and the Department of Health and Social Security (DHSS) and it is expected that ultimately the level of trace will be better than 97%. Mortality data not specifically related to radiation workers are included and relate to male deaths among serving staff and pensioners during the years 1962-1978. Those observed deaths (O) are compared on an age standardized basis with those expected (E) from the general population, the ratio O/E being about 1 for all cancers and less than 1 for non-cancer deaths. This pattern is consistent with the well known 'healthy worker' effect seen in industry. (author)

  10. Jaundice: a preliminary study with the ultrasound

    International Nuclear Information System (INIS)

    Chen Xiang; Sun Jian; Liu Haiping; Luo Weiquan

    2006-01-01

    Objective: To evaluate the ultrasound in imaging diagnosis of jaundice. Methods: The changes of ultrasonography of 116 patients with jaundice were correlatively studied with the final diagnosis. Results: Hepatocellular jaundice was found in 27 cases out of 116; and obstructive jaundice was revealed in other 89 cases. The level of obstruction was correctly assessed by ultrasound in 94.2% of the patients. The primary lesion was successfully identified by ultrasound in 87.6% cases of obstructive jaundice. Misdiagnosis was made in 8 cases. Conclusion: Ultrasonography can confirm the obstructive jaundice. The level of obstruction can be precisely located and the primary lesions can be correctly identified in most cases. Better understanding the sonographic characteristics of benign disorder such as inflam-matory mass of caput of pancreas and inflammatory stricture of common bile duct results in a higher diagnostic accuracy. (authors)

  11. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each. This volume contains the descriptions and other relevant information of the four subsystems required for most of the ex situ processing systems. This volume covers the metal decontamination and sizing subsystem, soils processing subsystem, low-level waste subsystem, and retrieval subsystem

  12. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Quapp, W.J.; Feizollahi, F.; Del Signore, J.C.

    1991-07-01

    The System Design Study (SDS), part of the Waste Technology Development Department at Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic (TRU) waste stored at the Radioactive Waste Management Complex's (RWMC's) Subsurface Disposal Area (SDA) at INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendices. 3 figs., 3 tabs

  13. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Quapp, W.J.; Feizollahi, F.; Del Signore, J.C.

    1991-07-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in Volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendixes. 23 refs., 23 figs., 16 tabs

  14. Preliminary geothermal study of Mt. Etna

    Energy Technology Data Exchange (ETDEWEB)

    Mongelli, F; Morelli, C

    1964-01-01

    The geothermal status of Italy's Mt. Etna region was studied via borehole thermometry at eight experimental sites. The mathematical principles and other criteria used in borehole site and well depth selection are discussed. The soil temperature is regulated by external temperature variations to a certain depth. The minimum drilling distance which would provide accurate temperature determinations was calculated to be 30 m. The geothermal gradient was determined by the application of a Fourier series to three measurements made at different depths using resistance thermometers. The results are presented in tables and the gradients are plotted on graphs. Geothermal gradient determinations were corrected for topographic effects. Two major groups of gradients were discovered, those having linear gradients were interpreted as being due to the effect of meteoric waters. Other possible disturbances are those caused by surface temperature effects and the influence of nearby bodies of water.

  15. Preliminary studies of cobalt complexation in groundwater

    International Nuclear Information System (INIS)

    Warwick, P.; Shaw, P.; Williams, G.M.; Hooker, P.J.

    1988-01-01

    A relatively non-invasive method has been used to separate complexed from free cobalt-60 in groundwater, using the weak cationic adsorption properties of Sephadex gels, and a mobile phase of natural groundwater. Results show the kinetics of Co complex formation in groundwater to be slow, and that the equilibrium position is affected by temperature, cobalt concentration and the ionic/organic strength of the groundwater. The addition of DAEA cellulose to the groundwater to remove humic material, also removed the majority of organic species which absorb UV at 254 nm, but 45% of the original total organic carbon remained, and the amount of complexed cobalt left in solution was only reduced to 76% of its former concentration. This suggests that the completed Co species separated by the method described in this paper are a mixture of inorganic and organic compounds, and studies are therefore continuing to establish their exact nature. (author)

  16. Preliminary studies of cobalt complexation in groundwater

    International Nuclear Information System (INIS)

    Warwick, P.; Shaw, P.; Williams, G.M.; Hooker, P.J.

    1988-01-01

    A relatively non-invasive method has been used to separate complexed from free cobalt-60 in groundwater, using the weak cationic adsorption properties of Sephadex gels, and a mobile phase of natural groundwater. Results show the kinetics of Co complex formation in groundwater to be slow, and that the equilibrium position is affected by temperature, cobalt concentration and the ionic/organic strength of the groundwater. The addition of DEAE cellulose to the groundwater to remove humic material, also removed the majority of organic species with absorb UV at 254 nm, but 45% of the original total organic carbon remained, and the amount of complexed cobalt left in solution was only reduced to 76% of its former concentration. This suggests that the complexed Co species separated by the method described in this paper are a mixture of inorganic and organic compounds, and studies are therefore continuing to establish their exact nature. (orig.)

  17. Preliminary study of tin slag concrete mixture

    Science.gov (United States)

    Hashim, Mohd Jamil; Mansor, Ishak; Pauzi Ismail, Mohamad; Sani, Suhairy; Azmi, Azhar; Sayuti, Shaharudin; Zaidi Ibrahim, Mohd; Adli Anuar, Abul; Rahim, Abdul Adha Abdul

    2018-01-01

    The study focuses on practices to facilitate tin smelting industry to reduce radioactive waste product (Tin Slag) by diluting its radioactivity to a safe level and turning it to a safer infrastructural building product. In the process the concrete mix which include Portland cement, sand, tin slag, water and plasticizer are used to produce interlocking brick pavements, piles and other infrastructural products. The mixing method follows DOE (UK) standard method of mixing targeted at in selected compressive strength suitable for its function and durability. A batching machine is used in the mixing and six test cubes are produced for the test. The testing equipment used are a compressional machine, ultrasonic measurement and a Geiger Muller counter to evaluate of the concrete mix to find the lowest emission of radiation surface dose without compromising the strength of concrete mix. The result obtained indicated the radioactivity of tin slag in the mixing process has reduced to background level that is 0.5μSv/h while the strength and workability of the concrete has not been severely affected. In conclusion, the concrete mix with tin slag has shown the potential it can be turned into a safe beneficial infrastructural product with good strength.

  18. Sleep education in college: a preliminary study.

    Science.gov (United States)

    Tsai, Ling-Ling; Li, Sheng-Ping

    2004-12-01

    In this study we evaluated the effect of a two-credit (100 min./week) "Sleep Management" course on the sleep patterns of college students as the course progressed over an 18-wk. semester. Curricular activity included lectures, group discussions, and practice of self-evaluation of sleep. Instead of giving the students the whole list of sleep hygiene at the outset of the course, each concept of sleep hygiene was introduced and discussed under related lecture topics. A total of 241 students (131 men and 110 women) took the course and kept 7-day sleep logs three times. Concurrently, sleep-log data were collected from 65 students (32 men and 33 women) who were not taking the course. Both groups showed similar varieties of academic backgrounds and characteristics of sleep patterns at the beginning. Similarly, their sleep patterns, namely, rise time, nighttime awakenings, time asleep, time in bed, sleep efficiency, and rise time regularity, changed over the semester. Women in both groups had more nighttime awakenings. In contrast, sleep quality was progressively better for the group in the course but not for the control group. Only women in the course decreased their nap time in the second and third months. Thus, the course of "Sleep Management" only had a mild and limited effect on sleep patterns. The course content needs refinement to maximize influence on students' sleep patterns and habits, particularly, on reduction of insufficient sleep and daytime sleepiness which are the highest ranking sleep problems among college students.

  19. Preliminary feasibility study of modular reactors

    International Nuclear Information System (INIS)

    Yamaji, Kenji

    1987-01-01

    In the future, electric utilities will be required to make a switch-over to a more flexible and dynamic form of power supply due to the slowing growth of power demand, increasing uncertainty, the stagnating economy of increasing scale, the bottleneck of transmission and so on. Nuclear technology would also be required to adapt to this changing environment surrounding its development. The long term prospect of energy demand and nuclear power growth, and the evolution of commercial reactors in Japan are shown. The design of 1,300 MWe advanced LWRs has been completed, and as the reactors of next generation, the ultralarge LWRs of 1,500 - 1,800 MWe are suggested. However, there can be an alternative future for nuclear power development, and in this paper, the possibility for altering the image of conventional nuclear power technology by developing modular reactors which are economical even at small capacity, and can be sited in urban areas just like conventional thermal power plants is examined. The factors for the economical evaluation of modular reactors, learning effect and scale effect on the economy, the case study on a modular high temperature reactor designed by Interatom-GHT, and the possibility of siting in urban areas due to the system of inherent safety are reported. (Kako, I.)

  20. Zr-Sn-Nb alloys. Preliminary studies

    International Nuclear Information System (INIS)

    Danon, C.A.; Arias, D.E.

    1993-01-01

    Studies of the Zr-Sn-Nb diagram have been started, focussing on the Zr-rich corner, near the composition of Zirlo commercial alloy, Zr-1Sn-1Nb, and with Fe and O contents usual in nuclear grade materials. Three alloys were melted, namely Zr-4Sn-2.4Nb (A), Zr-1Sn-3Nb (B) and Zr-2.1Sn-1Nb (C). α/β transformation temperatures were measured through the variation of electrical resistivity(p) vs temperature (T). Values of 560 deg C, 670 deg C and 750 deg C were measured for the α→α+β reaction and 980 deg C, 910 deg C and 1000 deg C for the α+β→β reaction, for the A, B and C alloys, respectively in that order. Some samples were submitted to heat treatments (62 and 216 hours at 825 deg C, 120 hours at 875 deg C). Optical and scanning electronic microscopy of those samples confirmed our resistivity results. (Author)

  1. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques for the remediation of hazardous and transuranic waste stored at Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume contains introduction section containing a brief SDS background and lists the general assumptions and considerations used during the development of the system concepts. The introduction section is followed by sections describing two system concepts that produce a waste form in compliance with the Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria (WAC) and transportation package (TRAMPAC) requirements. This system concept category is referred to as Waste Form 4, ''WIPP and TRAMPAC Acceptable.'' The following two system concepts are under this category: Sort, Treat, and Repackage System (4-BE-2); Volume Reduction and Packaging System (4-BE-4)

  2. Preliminary design study for a corkscrew gantry

    International Nuclear Information System (INIS)

    Koehler, A.M.

    1987-01-01

    For two years or more a group including the author has been working together to study some problems related to the design of a gentry system for flexible direction of a proton beam for clinical treatments. Some consideration was given to the classic gantry geometry. Attempting to reduce the radius of the gantry arm by reducing the drift space after the scattering foils led to an analysis of the significance of inverse square intensity effects. The conclusion reached is that a drift space of about 3 meters is required to preserve some skin sparing for larger targets. To circumvent this problem the scattering foils ere put somewhere inside or even before the gantry system, accepting the fact that magnet apertures would have to be increased. This gantry system has the interesting ability to produce oblong fields of excellent uniformity with reasonable efficiency, preferentially with the long axis of the field parallel to the axis of rotation. It was disappointing, however, to find that the overall size of the gantry with its counterweights remained very large. Another change in geometry was proposed therefore in order to reduce the space taken up by the gantry and its counterweight. The beam is bent 45 0 in the horizontal plane and then again by 45 0 so that it is pointing away from isocenter, but in the plan of rotation of the gantry. The beam is now bent in that plane of rotation until it is pointed at isocenter. This is accomplished by two bends of 135 0 each with a suitable drift space between them so that the beam is pointed vertically downward at isocenter. The three dimensional complexity of the beam trajectory led to the name Corkscrew Gantry

  3. Market based consumer adaptation. Preliminary study

    International Nuclear Information System (INIS)

    Saele, Hanne

    2005-04-01

    This report is a foundation for further research in the project ''Market based consumer adaptation'', project period 2005-2008. The report describes characteristics of shortage periods for both energy and effects, low priority consumption, power products and network tariffs that may contribute to increased flexibility in consumption and limitations in the IT-systems of today and discusses what problems would be of interest for further studies. The reduction of low priority consumption and the activation of price elasticity would be challenges both for effect and energy shortages. Private consumption would however, partly be different due to the time perspective. It is expected that periods of effect shortages would be of only a few hours and the challenge would be to obtain sufficient response at an hourly basis at load disconnection. The energy shortage is expected to last longer which results in problems in obtaining sufficient and real consumer reduction over time in order to reduce the danger of critical shortage. Important elements in order to supply new power products and network tariffs which contributes to increased flexibility in the consumption, are technology for current registration and remote control of consumption, contracts between the involved parties and the framework conditions that gives incentives for establishing new network/power products. When several parties shall use the same measurements for accounting it would be necessary for all the figures to arrive in time and that corrections are avoided as much as possible. It would also be challenging for the parties whether new products satisfy the regulations. Pricing in network tariffs is subject to more legal public regulations than developing a power product. This may make it difficult to produce ''correct'' network tariffs due to regulation and at the same time interest more customers to making deals with such tariffs. Even if the power suppliers to a certain extent, are more free to develop

  4. Preliminary design study of a steady state tokamak device

    International Nuclear Information System (INIS)

    Miya, Naoyuki; Nakajima, Shinji; Ushigusa, Kenkichi; and athors)

    1992-09-01

    Preliminary design study has been made for a steady tokamak with the plasma current of 10MA, as the next to the JT-60U experimental programs. The goal of the research program is the integrated study of steady state, high-power physics and technology. Present candidate design is to use superconducting TF and PF magnet systems and long pulse operation of 100's-1000's of sec with non inductive current drive mainly by 500keV negative ion beam injection of 60MW. Low activation material such as titanium alloy is chosen for the water tank type vacuum vessel, which is also the nuclear shield for the superconducting coils. The present preliminary design study shows that the device can meet the existing JT-60U facility capability. (author)

  5. Preliminary 2D design study for A ampersand PCT

    International Nuclear Information System (INIS)

    Keto, E.; Azevedo, S.; Roberson, P.

    1995-03-01

    Lawrence Livermore National Laboratory is currently designing and constructing a tomographic scanner to obtain the most accurate possible assays of radioactivity in barrels of nuclear waste in a limited amount of time. This study demonstrates a method to explore different designs using laboratory experiments and numerical simulations. In particular, we examine the trade-off between spatial resolution and signal-to-noise. The simulations are conducted in two dimensions as a preliminary study for three dimensional imaging. We find that the optimal design is entirely dependent on the expected source sizes and activities. For nuclear waste barrels, preliminary results indicate that collimators with widths of 1 to 3 inch and aspect ratios of 5:1 to 10:1 should perform well. This type of study will be repeated in 3D in more detail to optimize the final design

  6. Preliminary study of soil permeability properties using principal component analysis

    Science.gov (United States)

    Yulianti, M.; Sudriani, Y.; Rustini, H. A.

    2018-02-01

    Soil permeability measurement is undoubtedly important in carrying out soil-water research such as rainfall-runoff modelling, irrigation water distribution systems, etc. It is also known that acquiring reliable soil permeability data is rather laborious, time-consuming, and costly. Therefore, it is desirable to develop the prediction model. Several studies of empirical equations for predicting permeability have been undertaken by many researchers. These studies derived the models from areas which soil characteristics are different from Indonesian soil, which suggest a possibility that these permeability models are site-specific. The purpose of this study is to identify which soil parameters correspond strongly to soil permeability and propose a preliminary model for permeability prediction. Principal component analysis (PCA) was applied to 16 parameters analysed from 37 sites consist of 91 samples obtained from Batanghari Watershed. Findings indicated five variables that have strong correlation with soil permeability, and we recommend a preliminary permeability model, which is potential for further development.

  7. Preliminary closed Brayton cycle study for a space reactor application

    International Nuclear Information System (INIS)

    Guimaraes, Lamartine Nogueira Frutuoso; Carvalho, Ricardo Pinto de; Camillo, Giannino Ponchio

    2007-01-01

    The Nuclear Energy Division (ENU) of the Institute for Advanced Studies (IEAv) has started a preliminary design study for a Closed Brayton Cycle Loop (CBCL) aimed at a space reactor application. The main objectives of the study are to establish a starting concept for the CBCL components specifications, and to develop a demonstrative simulator of CBCL in nominal operation conditions. The ENU/IEAv preliminary design study is developing the CBCL around the NOELLE 60290 turbo machine. The actual nuclear reactor study is being conducted independently. Because of that, a conventional heat source is being used for the CBCL, in this preliminary design phase. This paper describes the steady state simulator of the CBCL operating with NOELLE 60290 turbo machine. In principle, several gases are being considered as working fluid, as for instance: air, helium, nitrogen, CO2 and gas mixtures such as helium and xenon. At this moment the simulator is running with Helium as the working fluid. Simplified models of heat and mass transfer are being developed to simulate thermal components. Future efforts will focus on keeping track of the modifications being implemented at the NOELLE 60290 turbo machine in order to build the CBCL. (author)

  8. Preliminary closed Brayton cycle study for a space reactor application

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Lamartine Nogueira Frutuoso; Carvalho, Ricardo Pinto de [Institute for Advanced Studies, Sao Jose dos Campos, SP (Brazil)]. E-mail: guimarae@ieav.cta.br; Camillo, Giannino Ponchio [Instituto Tecnologico de Aeronautica (ITA), Sao Jose dos Campos, SP (Brazil)]. E-mail: gianninocamillo@gmail.com

    2007-07-01

    The Nuclear Energy Division (ENU) of the Institute for Advanced Studies (IEAv) has started a preliminary design study for a Closed Brayton Cycle Loop (CBCL) aimed at a space reactor application. The main objectives of the study are to establish a starting concept for the CBCL components specifications, and to develop a demonstrative simulator of CBCL in nominal operation conditions. The ENU/IEAv preliminary design study is developing the CBCL around the NOELLE 60290 turbo machine. The actual nuclear reactor study is being conducted independently. Because of that, a conventional heat source is being used for the CBCL, in this preliminary design phase. This paper describes the steady state simulator of the CBCL operating with NOELLE 60290 turbo machine. In principle, several gases are being considered as working fluid, as for instance: air, helium, nitrogen, CO2 and gas mixtures such as helium and xenon. At this moment the simulator is running with Helium as the working fluid. Simplified models of heat and mass transfer are being developed to simulate thermal components. Future efforts will focus on keeping track of the modifications being implemented at the NOELLE 60290 turbo machine in order to build the CBCL. (author)

  9. Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming [Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009 (China); Yan, Fuhua, E-mail: zemylife@163.com [Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 (China)

    2014-05-15

    Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ{sup 2} = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up.

  10. Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

    International Nuclear Information System (INIS)

    Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming; Yan, Fuhua

    2014-01-01

    Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ 2 = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up

  11. Introducing a multifaceted exercise intervention particular to older adults diagnosed with Parkinson's disease: a preliminary study.

    Science.gov (United States)

    Peacock, Corey A; Sanders, Gabriel J; Wilson, Kayla A; Fickes-Ryan, Emily J; Corbett, Duane B; von Carlowitz, Kyle-Patrick A; Ridgel, Angela L

    2014-08-01

    With a substantial increase in diagnosed Parkinson's disease, it is of great importance to examine tolerance and physical measures of evolving exercise interventions. Of particular importance, a multifaceted exercise intervention combining active-assisted cycling and resistance training to older adults diagnosed with Parkinson's disease is being assessed. Fourteen older adults diagnosed with Parkinson's disease and ten healthy older adults (67.5 ± 7.9 years of age) engaged in an 8-week, 24-session, multifaceted exercise protocol. The protocol consisted of both active-assisted cycling and resistance training. Tolerance was measured, as well as multiple indicators of health-related physical fitness. These indicators examined improvements in cardiovascular performance, muscular strength, muscular endurance, and flexibility. Twenty-two older adults and older adults diagnosed with Parkinson's disease tolerated the intervention by completing all 24 sessions. Repeated-measures analysis of variance demonstrated significant (P ≤ 0.003) improvements in cardiovascular performance, muscular strength, muscular endurance, and flexibility for both groups of individuals. The multifaceted intervention is the first to combine both active-assisted cycling and resistance training. The older adult and the older adult diagnosed with Parkinson's disease exhibited both tolerance and health-related improvements in physical fitness following the intervention.

  12. Development and preliminary experimental study on micro-stacked insulator

    International Nuclear Information System (INIS)

    Ren Chengyan; Yuan Weiqun; Zhang Dongdong; Yan Ping; Wang Jue

    2009-01-01

    High gradient insulating technology is one of the key technologies in new type dielectric wall accelerator(DWA). High gradient insulator, namely micro-stacked insulator, was developed and preliminary experimental study was done. Based on the finite element and particle simulating method, surface electric field distribution and electron movement track of micro-stacked insulator were numerated, and then the optimized design proposal was put forward. Using high temperature laminated method, we developed micro-stacked insulator samples which uses exhaustive fluorinated ethylene propylene(FEP) as dielectric layer and stainless steel as metal layer. Preliminary experiment of vacuum surface flashover in nanosecond pulse voltage was done and micro-stacked insulator exhibited favorable vacuum surface flashover performance with flashover field strength of near 180 kV/cm. (authors)

  13. Preliminary Study of a Piston Pump for Cryogenic Fluids

    Science.gov (United States)

    Biermann, Arnold E.; Kohl, Robert C.

    1959-01-01

    Preliminary data are presented covering the performance of a low-speed, five-cylinder piston pump designed for handling boiling hydrogen. This pump was designed for a flow of 55 gallons per minute at 240 rpm with a discharge pressure of 135 pounds per square inch. Tests were made using JP-4 fuel, liquid nitrogen, and liquid hydrogen. Pump delivery and endurance characteristics were satisfactory for the range of operation covered. In connection with the foregoing pump development, the cavitation characteristics of a preliminary visual model, glass-cylinder pump and of a simple reciprocating disk were studied. Subcooling of approximately 0.60 F was obtained from the cavitation produced by reciprocating a disk in boiling nitrogen and in boiling water. The subcooling obtained in a similar manner with liquid hydrogen was somewhat less.

  14. TREE STEM RECONSTRUCTION USING VERTICAL FISHEYE IMAGES: A PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    A. Berveglieri

    2016-06-01

    Full Text Available A preliminary study was conducted to assess a tree stem reconstruction technique with panoramic images taken with fisheye lenses. The concept is similar to the Structure from Motion (SfM technique, but the acquisition and data preparation rely on fisheye cameras to generate a vertical image sequence with height variations of the camera station. Each vertical image is rectified to four vertical planes, producing horizontal lateral views. The stems in the lateral view are rectified to the same scale in the image sequence to facilitate image matching. Using bundle adjustment, the stems are reconstructed, enabling later measurement and extraction of several attributes. The 3D reconstruction was performed with the proposed technique and compared with SfM. The preliminary results showed that the stems were correctly reconstructed by using the lateral virtual images generated from the vertical fisheye images and with the advantage of using fewer images and taken from one single station.

  15. A preliminary conceptual design study for Korean fusion DEMO reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Keeman, E-mail: kkeeman@nfri.re.kr [National Fusion Research Institute, 169-148 Gwahak-ro, Daejeon 305-806 (Korea, Republic of); Kim, Hyoung Chan; Oh, Sangjun; Lee, Young Seok; Yeom, Jun Ho; Im, Kihak; Lee, Gyung-Su [National Fusion Research Institute, 169-148 Gwahak-ro, Daejeon 305-806 (Korea, Republic of); Neilson, George; Kessel, Charles; Brown, Thomas; Titus, Peter [Princeton Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States)

    2013-10-15

    Highlights: ► Perform a preliminary conceptual study for a steady-state Korean DEMO reactor. ► Present design guidelines and requirements of Korean DEMO reactor. ► Present a preliminary design of TF (toroidal field) and CS (central solenoid) magnet. ► Present a preliminary result of the radial build scheme of Korean DEMO reactor. -- Abstract: As the ITER is being constructed, there is a growing anticipation for an earlier realization of fusion energy, so called fast-track approach. Korean strategy for fusion energy can be regarded as a fast-track approach and one special concept discussed in this paper is a two-stage development plan. At first, a steady-state Korean DEMO Reactor (K-DEMO) is designed not only to demonstrate a net electricity generation and a self-sustained tritium cycle, but also to be used as a component test facility. Then, at its second stage, a major upgrade is carried out by replacing in-vessel components in order to show a net electric generation on the order of 300 MWe and the competitiveness in cost of electricity (COE). The major radius is designed to be just below 6.5 m, considering practical engineering feasibilities. By using high performance Nb{sub 3}Sn-based superconducting cable currently available, high magnetic field at the plasma center above 8 T can be achieved. A design concept for TF magnets and radial builds for the K-DEMO considering a vertical maintenance scheme, are presented together with preliminary design parameters.

  16. Online gaming dependency: a preliminary study in China.

    Science.gov (United States)

    Peng, Wei; Liu, Ming

    2010-06-01

    Based on theories and previous studies on problematic Internet use, we propose a model to better understand the contributors to and consequences of online gaming dependency. A preliminary study was conducted through a survey of online gamers in China. The results of path analysis found that maladaptive cognitions, shyness, and depression are positively related to online gaming dependency. Online gaming dependency was also positively related to different types of negative life outcomes. The findings of this study have implications for the prevention and treatment of addictive online gaming.

  17. Chronic rhinosinusitis in Europe - an underestimated disease. A GA(2) LEN study

    DEFF Research Database (Denmark)

    Hastan, D; Fokkens, W J; Bachert, C

    2011-01-01

    , Zuberbier T, Jarvis D, Burney P. Chronic rhinosinusitis in Europe - an underestimated disease. A GA(2) LEN study. Allergy 2011; 66: 1216-1223. ABSTRACT: Background:  Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence...

  18. Biocontamination Control for Spacesuit Garments - A Preliminary Study

    Science.gov (United States)

    Rhodes, Richard A.; Orndoff, Evelyne; Korona, F. Adam; Poritz, Darwin; Smith, Jelanie; Wong, Wing

    2011-01-01

    This paper outlines a preliminary study that was conducted to review, test, and improve on current space suit biocontamination control. Biocontamination from crew members can cause space suit damage and objectionable odors and lead to crew member health hazards. An understanding of the level of biocontamination is necessary to mitigate its effects. A series of tests were conducted with the intent of evaluating current suit materials, ground and on-orbit disinfectants, and potential commercial off-the-shelf antimicrobial materials. Included in this paper is a discussion of the test methodology, results, and analysis method.

  19. Radiology workstation for mammography: preliminary observations, eyetracker studies, and design

    Science.gov (United States)

    Beard, David V.; Johnston, Richard E.; Pisano, Etta D.; Hemminger, Bradley M.; Pizer, Stephen M.

    1991-07-01

    For the last four years, the UNC FilmPlane project has focused on constructing a radiology workstation facilitating CT interpretations equivalent to those with film and viewbox. Interpretation of multiple CT studies was originally chosen because handling such large numbers of images was considered to be one of the most difficult tasks that could be performed with a workstation. The authors extend the FilmPlane design to address mammography. The high resolution and contrast demands coupled with the number of images often cross- compared make mammography a difficult challenge for the workstation designer. This paper presents the results of preliminary work with workstation interpretation of mammography. Background material is presented to justify why the authors believe electronic mammographic workstations could improve health care delivery. The results of several observation sessions and a preliminary eyetracker study of multiple-study mammography interpretations are described. Finally, tentative conclusions of what a mammographic workstation might look like and how it would meet clinical demand to be effective are presented.

  20. Corporate Social Disclosures in Southeast Asia: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Juniati Gunawan

    2012-12-01

    Full Text Available The issue of Corporate Social Disclosure (CSD has been growing remarkably both in business and academic world.  Inevitably, this topic is also exposed in Southeast Asia, a big region that plays important role in global economic issue. Applying a content analysis method, this paper aims to provide preliminary findings in CSD practices throughout the companies‟ annual reports in 2007 and 2008 for countries located in Southeast Asia.  Samples were selected for listed and unlisted various type of industries, based on the information availability internet searching. The sample collection and the subjectivity during the content analysis process are the limitations in conducting this study. In general, the results show that „human resources‟ are the main information disclosed, while in contrast, „energy‟ is the main least issue disclosed in the annual reports.  However, the findings need to be interpreted with considerations since there are limited in samples. Basically, the outcomes support the major prior studies and enhancing the discussion of CSD conducting in developing countries, while at the same time describing some countries which obtained very limited in exposures. To respond the vast increasing issues of CSD practice, this preliminary study has provided a basis to see the role of every country in CSR reporting and how they could support the sustainability development globally.

  1. Preliminary design study of the TMT Telescope structure system: overview

    Science.gov (United States)

    Usuda, Tomonori; Ezaki, Yutaka; Kawaguchi, Noboru; Nagae, Kazuhiro; Kato, Atsushi; Takaki, Junji; Hirano, Masaki; Hattori, Tomoya; Tabata, Masaki; Horiuchi, Yasushi; Saruta, Yusuke; Sofuku, Satoru; Itoh, Noboru; Oshima, Takeharu; Takanezawa, Takashi; Endo, Makoto; Inatani, Junji; Iye, Masanori; Sadjadpour, Amir; Sirota, Mark; Roberts, Scott; Stepp, Larry

    2014-07-01

    We present an overview of the preliminary design of the Telescope Structure System (STR) of Thirty Meter Telescope (TMT). NAOJ was given responsibility for the TMT STR in early 2012 and engaged Mitsubishi Electric Corporation (MELCO) to take over the preliminary design work. MELCO performed a comprehensive preliminary design study in 2012 and 2013 and the design successfully passed its Preliminary Design Review (PDR) in November 2013 and April 2014. Design optimizations were pursued to better meet the design requirements and improvements were made in the designs of many of the telescope subsystems as follows: 1. 6-legged Top End configuration to support secondary mirror (M2) in order to reduce deformation of the Top End and to keep the same 4% blockage of the full aperture as the previous STR design. 2. "Double Lower Tube" of the elevation (EL) structure to reduce the required stroke of the primary mirror (M1) actuators to compensate the primary mirror cell (M1 Cell) deformation caused during the EL angle change in accordance with the requirements. 3. M1 Segment Handling System (SHS) to be able to make removing and installing 10 Mirror Segment Assemblies per day safely and with ease over M1 area where access of personnel is extremely difficult. This requires semi-automatic sequence operation and a robotic Segment Lifting Fixture (SLF) designed based on the Compliance Control System, developed for controlling industrial robots, with a mechanism to enable precise control within the six degrees of freedom of position control. 4. CO2 snow cleaning system to clean M1 every few weeks that is similar to the mechanical system that has been used at Subaru Telescope. 5. Seismic isolation and restraint systems with respect to safety; the maximum acceleration allowed for M1, M2, tertiary mirror (M3), LGSF, and science instruments in 1,000 year return period earthquakes are defined in the requirements. The Seismic requirements apply to any EL angle, regardless of the

  2. Preliminary conceptual study of engineering-scale pyroprocess demonstration facility

    International Nuclear Information System (INIS)

    Moon, Seong-In; Chong, Won-Myung; You, Gil-Sung; Ku, Jeong-Hoe; Kim, Ho-Dong

    2013-01-01

    Highlights: ► The conceptual design of a pyroprocess demonstration facility was performed. ► The design requirements for the pyroprocess hot cell and equipment were determined. ► The maintenance concept for the pyroprocess hot cell was presented. -- Abstract: The development of an effective management technology of spent fuel is important to enhance environmental friendliness, cost viability and proliferation resistance. In Korea, pyroprocess technology has been considered as a fuel cycle option to solve the spent fuel accumulation problems. PRIDE (PyRoprocess Integrated inactive DEmonstration facility) has been developed from 2007 to 2012 in Korea as a cold test facility to support integrated pyroprocessing and an equipment demonstration, which is essential to verify the pyroprocess technology. As the next stage of PRIDE, the design requirements of an engineering-scale demonstration facility are being developed, and the preliminary conceptual design of the facility is being performed for the future. In this paper, the main design requirements for the engineering-scale pyroprocess demonstration facility were studied in the throughput of 10tHM a year. For the preliminary conceptual design of the facility, the design basis of the pyroprocess hot cell was suggested, and the main equipment, main process area, operation area, maintenance area, and so on were arranged in consideration of the effective operation of the hot cells. Also, the argon system was designed to provide and maintain a proper inert environment for the pyroprocess. The preliminary conceptual design data will be used to review the validity of the engineering-scale pyroprocess demonstration facility that enhances both safety and nonproliferation

  3. THE COMPATIBILITY STUDENT CHOICE OF UNIVERSITY MAJORING; A PRELIMINARY STUDIES

    Directory of Open Access Journals (Sweden)

    Daharnis Daharnis

    2016-06-01

    Full Text Available The continuous improvements in order to optimize the basic education to higher education are still running. Based on that purpose, there are many factors to supporting the students' learning activities success; one of the factors is suitability with majors in university. The purpose of this study is to reveal the condition of the compatibility of students majoring with their interest, then to describe the information when the student choose their majoring. Samples in this study were 122 peoples, taken by random sampling from the Padang State University. Data obtained by distributing questionnaires. The results showed that there are students that their major do not match with their interest (22.13%, only 3.28% of students who feel compatible with their major. This result should be a major concern, particularly for counselor in schools for design counseling services to solve these problems. The result of this study used as a grand tour or a preliminary study for further research.

  4. Nevada potential repository preliminary transportation strategy Study 2. Volume 1

    International Nuclear Information System (INIS)

    1996-02-01

    The objectives of this study were to build on the findings of the Nevada Potential Repository Preliminary Transportation Strategy Study 1 (CRWMS M ampersand O 1995b), and to provide additional information for input to the repository environmental impact statement (EIS) process. In addition, this study supported the future selection of a preferred rail corridor and/or heavy haul route based on defensible data, methods, and analyses. Study research did not consider proposed legislation. Planning was conducted according to the Civilian Radioactive Waste Management Program Plan (DOE 1994a). The specific objectives of Study 2 were to: eliminate or reduce data gaps, inconsistencies, and uncertainties, and strengthen the analysis performed in Study 1; develop a preliminary list of rail route evaluation criteria that could be used to solicit input from stakeholders during scoping meetings. The evaluation criteria will be revised based on comments received during scoping; restrict and refine the width of the four rail corridors identified in Study 1 to five miles or less, based on land use constraints and engineering criteria identified and established in Study 2; evaluate national-level effects of routing spent nuclear fuel and high-level waste to the four identified branch lines, including the effects of routing through or avoiding Las Vegas; continue to gather published land use information and environmental data to support the repository EIS; continue to evaluate heavy haul truck transport over three existing routes as an alternative to rail and provide sufficient information to support the repository EIS process; and evaluate secondary uses for rail (passenger use, repository construction, shared use)

  5. R and D Requirements, RF Gun Mode Studies, FEL-2 Steady-State Studies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary Layout Option Investigation

    International Nuclear Information System (INIS)

    Byrd, John; Corlett, John; Doolittle, Larry; Fawley, William; Lidia, Steven; Penn, Gregory; Ratti, Alex; Staples, John; Wilcox Russell; Wurtele, Jonathan; Zholents, Alexander

    2005-01-01

    This report constitutes the third deliverable of LBNLs contracted role in the FERMI (at) Elettra Technical Optimization study. It describes proposed RandD activities for the baseline design of the Technical Optimization Study, initial studies of the RF gun mode-coupling and potential effects on beam dynamics, steady-state studies of FEL-2 performance to 10 nm, preliminary studies of time-dependent FEL-1 performance using electron bunch distribution from the start-to-end studies, and a preliminary investigation of a configuration with FEL sinclined at a small angle from the line of the linac

  6. Modeling and Testing of EVs - Preliminary Study and Laboratory Development

    DEFF Research Database (Denmark)

    Yang, Guang-Ya; Marra, Francesco; Nielsen, Arne Hejde

    2010-01-01

    Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... tests, followed by the suggestions towards a feasible battery model for further studies.......Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... impact at different geographical areas, as well as driving and charging patterns. Electric circuit model is deployed in this work to represent the electrical properties of a lithium-ion battery. This paper reports the preliminary modeling and validation work based on manufacturer data sheet and realistic...

  7. Preliminary study on the establishment of the radionuclide declaration methods for radionuclides in LILW radioactive waste

    International Nuclear Information System (INIS)

    Hwang, K. H.; Lee, K. J.; Jung, C. W.

    2003-01-01

    The preliminary study on declaration methods has been done for each radionuclide in LILW radwaste drum in Korean NPPs. View from the preliminary establishment of radio nuclide declaration methods, The selection of assessment target nuclide through the qualitative method and preliminary criteria for routine declaration methods in each radio nuclide was derived. First of all, selection criteria and preliminary assessment method for each target radionuclide was surveyed and investigated. And, the selection criteria and selected the target radio nuclides from the basis on criteria was derived. And the preliminary suggestion about the declaration methods for each target radio nuclide was established

  8. Preliminary design study of a large scale graphite oxidation loop

    International Nuclear Information System (INIS)

    Epel, L.G.; Majeski, S.J.; Schweitzer, D.G.; Sheehan, T.V.

    1979-08-01

    A preliminary design study of a large scale graphite oxidation loop was performed in order to assess feasibility and to estimate capital costs. The nominal design operates at 50 atmospheres helium and 1800 F with a graphite specimen 30 inches long and 10 inches in diameter. It was determined that a simple single walled design was not practical at this time because of a lack of commercially available thick walled high temperature alloys. Two alternative concepts, at reduced operating pressure, were investigated. Both were found to be readily fabricable to operate at 1800 F and capital cost estimates for these are included. A design concept, which is outside the scope of this study, was briefly considered

  9. Possession experiences in dissociative identity disorder: a preliminary study.

    Science.gov (United States)

    Ross, Colin A

    2011-01-01

    Dissociative trance disorder, which includes possession experiences, was introduced as a provisional diagnosis requiring further study in the Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Consideration is now being given to including possession experiences within dissociative identity disorder (DID) in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.), which is due to be published in 2013. In order to provide empirical data relevant to the relationship between DID and possession states, I analyzed data on the prevalence of trance, possession states, sleepwalking, and paranormal experiences in 3 large samples: patients with DID from North America; psychiatric outpatients from Shanghai, China; and a general population sample from Winnipeg, Canada. Trance, sleepwalking, paranormal, and possession experiences were much more common in the DID patients than in the 2 comparison samples. The study is preliminary and exploratory in nature because the samples were not matched in any way.

  10. Microangiographic study of the canine dental tissues: a preliminary report

    International Nuclear Information System (INIS)

    Miyabayashi, T.; Morgan, J.P.

    1987-01-01

    A microangiographic study of the dental tissues was performed on one adult mongrel dog to examine the usefulness of the technique. This preliminary study used 30% wt/vol Micropaque suspension which was perfused into the common carotid arteries. After the complete perfusion, the specimen was fixed into a mixture of 10% buffered neutral formalin solution and 95% ethyl alcohol. The mandibular bone with teeth in situ was decalcified. The specimen was embedded in methyl methacrylate. One mm slab sections were made, and then the microangiographs were made. Adequate filling of arterioles was evident on the microangiographs. This technique is shown to be useful in characterizing the nature of the blood supply to the bone and teeth that might be involved in the pathogenesis of radiation-induced injury in the canine dental and periodontal tissues

  11. Radiological follow-up of uncemented knee prostheses. Preliminary study

    International Nuclear Information System (INIS)

    Martin Hervas, C.; Gomez Barrena, E.; Marquez Moreno, I.; Calle Yuste, F.; Ordonez Parra, J.M.

    1993-01-01

    The preliminary results of a prospective study of 40 uncemented total knee prostheses (TKP) are presented following a radiological protocol with fluoroscopic control and follow-up of over 2 years. The prosthesis-bone interface and the components alignment were assessed. Several radiological signs were studied to assess this interface with respect to the fixing of the component, but they showed little clinical correlation. Statistical significance (p<0.05, chisquare) was found only in the observation of sclerosis in areas of support for the tibital tray as a reaction of the bone. This radiological follow-up is of interest to determine the evolution of the interface and position of the implant to prevent complications (especially loosening) in patients, particularly those under 60 years old, who represent the group that can most benefit from prosthetic systems with uncemented anchorage because of their life expectation and level of activity. Author

  12. Preliminary economic feasibility study of MIP (Medical Isotopes Producer)

    International Nuclear Information System (INIS)

    Mon, G. H.; O, S. Y.

    2004-01-01

    Preliminary economic feasibility study of MIP (Medical Isotopes Producer), which is used liquid nuclear fuel to produce medical isotopes of Mo-99 and Sr-89, was performed. To do this, this study was estimated the IRR(Internal Rate of Return) and PBP(Pay-back Period) about optimistic and pessimistic cases for market penetration of Asia and U.S.A. isotope markets. And sensitivity analysis is also performed about capital cost and price of Mo-99 and Sr-89. According to the results, IRR was between 14.9% and 24.3%, and PBP was between 4.8 years and 7.8 years. These suggest that MIP has economic merits. MIP can produce other medical isotopes such as Sr-90, I-131, Xe-133, Cs-137. So, it is necessary to do cost-benefit analysis considering production of these other isotopes

  13. Preliminary study on metallic inclusion in nuclear fuel

    International Nuclear Information System (INIS)

    Fukuzawa, Takashi; Tanaka, Masahiro; Tanabe, Tetsuo; Imoto, Shosuke

    1984-01-01

    In recent postirradiation tests, metallic fission products such as Mo, Ru, Rh and Pd are known to precipitate as metallic inclusions in the fuel. These inclusions remain as insoluble residues and provide various problems in different fields of the reprocessing. In this report are presented preliminary results of the study on the ternary phase diagram of Mo-Ru-Pd system and on their properties in nitric acid or various oxidative environments. It is concluded that (1) most of metallic inclusions which are insoluble in nitric acid show epsilon phase, Ru base hcp alloy, in which a large amount of Mo and Pd are soluble, (2) Pd, however, seems to deposit separately in the fuel pin because of its high vapor pressure, (3) Mo fraction in the inclusion would be highly dependent on oxygen potential in the fuel pin. (author)

  14. Preliminary Study of RFID System for the LILW Transportation

    International Nuclear Information System (INIS)

    Kim, Dohyung; Lee, Unjang; Choi, Kyusup

    2008-01-01

    Radio-Frequency Identification (RFID) is an automatic identification method, relying on storing and remotely retrieving data using devices called RFID tags or transponders. In Korea, Low-to-Intermediate Level Radioactive Wastes (LILW) are planed to be disposed at Kyeonju disposal repository, and 100,000 LILW drums will be disposed for the first 10 years of disposal. Tracking of these LILW drums is one of the important parts for safe transportation. To track the LILW drums during the transport as well as storage and disposal, RFID can be the prospective method for tracking the LILW drums. In this report, RFID system is introduced to the LILW transport from the generation site to disposal site, and one possible RFID system is suggested as a preliminary study

  15. Preliminary study of magnet design for an SSC

    International Nuclear Information System (INIS)

    Taylor, C.E.; Meuser, R.B.

    1983-08-01

    The overriding design consideration for the SSC magnets is that cost of the facility be minimized; at 8 T, approximately 40 km of bending magnets is required for each ring of a 20 TeV collider. We present some results of a parametric study of two-in-one, iron-core magnets for an SSC. These results are necessarily preliminary in nature, and are intended only to show some of the trade-offs for a wide range of the variables. We show also some results for a reference design that produces 6.5 T in the aperture at 4.4 K for a coil inside diameter of 40 mm. It is not to be inferred that we have established this to be an optimum in any sense

  16. Preliminary study on improving safety culture in Malaysian nuclear industries

    International Nuclear Information System (INIS)

    Ibrahim, Sabariah Kader; Lee, Y. E.

    2012-01-01

    This paper presents preliminary study on safety culture and its implementation in Malaysian nuclear industries by realizing the importance of safety culture; identification of important safety culture attributes; safety culture assessment and the practices to incorporate the identified safety culture attributes in organization. The first section of this paper explains the terms and definitions related to safety culture. Second, for the realization of importance of safety culture in organization, the international operational experiences emphasizing the importance of safety culture are described. Third, important safety culture attributes which are frequently cited in literature are provided. Fourth, methods to assess safety culture in operating organization are described. Finally, the practices to enhance the safety culture in an organization are discussed

  17. Preliminary study on improving safety culture in Malaysian nuclear industries

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, Sabariah Kader [KAIST, Daejeon (Korea, Republic of); Lee, Y. E. [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2012-10-15

    This paper presents preliminary study on safety culture and its implementation in Malaysian nuclear industries by realizing the importance of safety culture; identification of important safety culture attributes; safety culture assessment and the practices to incorporate the identified safety culture attributes in organization. The first section of this paper explains the terms and definitions related to safety culture. Second, for the realization of importance of safety culture in organization, the international operational experiences emphasizing the importance of safety culture are described. Third, important safety culture attributes which are frequently cited in literature are provided. Fourth, methods to assess safety culture in operating organization are described. Finally, the practices to enhance the safety culture in an organization are discussed.

  18. Small hydropower station in Lavin - Preliminary study; Kleinwasserkraftwerk Lavin - Vorstudie

    Energy Technology Data Exchange (ETDEWEB)

    Merz, F.

    2008-05-15

    This illustrated final report for the Swiss Federal Office of Energy (SFOE) presents the results of a preliminary study regarding a proposed small hydropower installation on the alpine river Lavinuoz in Lavin, Switzerland. The geographical situation with mountains and glaciers in the catchment area of the proposed hydropower installation is discussed as are the appropriate water catchment installations. Possible dangers caused by avalanches and rock fall are examined. The power to be produced - 5,500,000 kWh/y - by the turbine which is nominally rated at 1350 kW is discussed, as are estimates of production costs. Figures on the investments required and the economic feasibility of the project are discussed, as are environmental factors that are to be taken into account.

  19. Strengths only or strengths and relative weaknesses? A preliminary study.

    Science.gov (United States)

    Rust, Teri; Diessner, Rhett; Reade, Lindsay

    2009-10-01

    Does working on developing character strengths and relative character weaknesses cause lower life satisfaction than working on developing character strengths only? The present study provides a preliminary answer. After 76 college students completed the Values in Action Inventory of Strengths (C. Peterson & M. E. P. Seligman, 2004), the authors randomly assigned them to work on 2 character strengths or on 1 character strength and 1 relative weakness. Combined, these groups showed significant gains on the Satisfaction With Life Scale (E. Diener, R. A. Emmons, R. J. Larsen, & S. Griffin, 1985), compared with a 32-student no-treatment group. However, there was no significant difference in gain scores between the 2-strengths group and the 1-character-strength-and-1-relative-character-weakness group. The authors discuss how focusing on relative character weaknesses (along with strengths) does not diminish-and may assist in increasing-life satisfaction.

  20. Preliminary Studies Of A Phase Modulation Technique For Measuring Chromaticity

    International Nuclear Information System (INIS)

    Tan, C.-Y.

    2006-01-01

    The classical method for measuring chromaticity is to slowly modulate the RF frequency and then measure the betatron tune excursion. The technique that is discussed in this paper instead modulates the phase of the RF and then the chromaticity is obtained by phase demodulating the betatron tune. This technique requires knowledge of the betatron frequency in real time in order for the phase to be demodulated. Fortunately, the Tevatron has a tune tracker based on the phase locked loop principle which fits this requirement. A preliminary study with this technique has showed that it is a promising method for doing continuous chromaticity measurement and raises the possibility of doing successful chromaticity feedback with it

  1. A preliminary feasibility study on natural analogue in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chun Soo; Bae, Dae Seok; Kim, Kyung Su; Koh, Yong Kwon; Park, Byung Yun

    2000-03-01

    Preliminary study on the assessment of natural analogue study in Korea for the deep geological disposal of high-level radioactive waste was carried out. The project on natural analogue study in other countries are introduced. The uranium-bearing deposit in Okcheon belt are summarized, which reported to be uranium-bearing minerals in order to assess to feasibility for natural analogue study in Korea. Among the uranium-bearing deposits, the Deokpyeong area, reported to be the highest reservoir and grade, are selected as the study site, and the elementary investigation, including survey of radioactivity and geochemistry are carried out. According to the investigation of surface environment, the radioactivity and uranium content in the surface water and shallow groundwater does not show any anormal values. However, the radioactivity is expected to be increased in depth and the groundwater reacted with uranium-bearing graphite formation shows high unanium content, indicating the potential possibility for natural analogue study in Korea. In future, if more detail study are performed, the assessment of natural analogue study in Korea are expected.

  2. [Stress at work among military doctors: a preliminary study].

    Science.gov (United States)

    Knezević, Bojana; Belosević, Ljiljana

    2006-09-01

    This preliminary study examined the sources of work stress in military physicians. Forty-eight medical doctors (24 military and 24 civilian) completed a questionnaire on stressors at the work place. The participation in the study was anonymous and voluntary. Out of 24 military physicians, 14 were military general practitioners (mean age 40.5, 14 female), and 10 were consultants of different specialties (mean age 43.5, 7 male and 3 female). Civilian physicians included 13 general practitioners working at primary health care system (mean age 37, 3 male and 10 female), and 11 consultants of different specialties working at out of hospital practice (average age 37, 6 male and 5 female). The questionnaire included items aiming to obtain demographic characteristics (sex, age, marital status, children, academic degree, clinical specialty, work place, average time in practice, average time at current position) and 37 items to determine occupational stressors. The stressors were related to work management, professional demands, interpersonal and patient-doctor relationship. Differences in recognizing work stressors between the groups of civilian and military physicians were statistically analyzed by using chi-squared-test. The leading work stressors identified by military physicians were inadequate salary, being bypassed for promotion, inadequate continuous education, poor resources, poor communication with superiors, poor management, trouble with superiors, excessive paperwork, unpredictable situations, and 24-hour standby. Civilian physicians reported inadequate salary, poor resources, poor management, misinformed patients, lack of co-workers, lack of time, unpredictable situations, exposure to indictment, dealing with incurable patients and exposure to public criticism and judgment. In comparison with civilian physicians, military physicians significantly more frequently reported inadequate salary (pcommunication with superiors (pcommunication with superiors (12

  3. Naphtha interaction with bitumen and clays : a preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Afara, M.; Munoz, V.; Mikula, R. [Natural Resources Canada, Devon, AB (Canada). CANMET Western Research Centre

    2010-07-01

    This PowerPoint presentation described a preliminary study conducted to characterize naphtha interactions with bitumen and clays. Coarse tailings, fluid-fine tailings, and froth treatment tailings are produced as a result of surface mine oil sands operations. Solvents are used to produce the bitumens, but the actual fraction of the solvent that evaporates and contributes to VOCs from tailing ponds is poorly understood. This study examined the interactions between the solvent, bitumen and mineral components in froth treatment tails. The study was conducted with aim of quantifying the VOC or solvent escaping from the froth treatment tailings. Samples containing bitumen, clay, a bitumen-clay mixture, or MFT were spiked with 3000 ppm of solvent. The amount of naphtha released was monitored by gas chromatography, mass spectrometry, and flame ionization detection of the evolved gases. The results were expressed as a percentage of the total hydrocarbon peak area of the sample versus a control. Results of the study showed that the naphtha interacted more strongly with the bitumen than with kaolinite and the clay minerals from the oil sands. Although initial solvent evaporation was reduced in the presence of bitumens and clays, long-term solvent releases will need to be quantified. tabs., figs.

  4. Subseabed radionuclide migration studies and preliminary repository design concepts

    International Nuclear Information System (INIS)

    Brush, L.H.

    1982-01-01

    Geochemical research carried out by the US Subseabed Disposal Program is described. Data from studies of high-temperature interactions between sediments and pore water (seawater) and from studies of sorption and diffusion of radionuclides in oxidized, deep-sea sediments are used, along with results from heat transfer studies, to predict migration rates of raionuclides in a subseabed repository. Preliminary results for most radionuclides in oxidized sediments are very encouraging. Fission products with moderate K/sub D/ values (10 2 to 10 5 ml/g) and actinides with high K/sub D/ values (10 3 to 10 6 ml/g) would not migrate significant distances before decaying to innocuous concentrations. Among this group are 137 Cs, 90 Sr, and 239 Pu. The results for anionic species in oxidized sediments are less encouraging. Planning for field verification of these laboratory and modeling studies is currently under way. Conceptual repository designs and emplacement options are also described. 33 references, 15 figures, 1 table

  5. Preliminary studies on the optimization of countermeasures for agricultural areas

    International Nuclear Information System (INIS)

    Rochedo, Elaine R.R.; Igreja, Eduardo; Barboza, Adriana E.; Silva, Diogo N.G. da; Guimaraes, Jean R.D.; Perez, Daniel V.

    2015-01-01

    The assessment of remediation measures for rural areas is more complex than that for urban ones, due to the influence of large number of variables associated with climate, diet, farming practices and the type of soil. Thus, it is not possible to perform generic studies applicable to all types of area. Specific studies and surveys should be made in the areas most likely to contamination from a nuclear accident. Preliminary studies demonstrated that the different soil types in Brazil is more relevant to the ingestion dose than the regional differences in diets. Other studies have described the prioritization of areas and products for detailed survey on soil types and remediation procedures, for an accident at the NPP in Angra dos Reis, based on radiological and economic aspects. The most relevant product was milk, due to both its relevance to the intake and the loss of income for the counties. The contribution of milk to dose depends on the season of the year when the accident occurs, mainly due to the relative contribution of other items of the diet. The timing of the application of the countermeasure has an important effect on the dose reduction that can be achieved. For I-131, protective measures must be considered within the emergency phase in order to be effective. The main action on reducing ingestion doses is the removal of food items from diet, while providing clean food to the population. (author)

  6. Preliminary studies on the optimization of countermeasures for agricultural areas

    Energy Technology Data Exchange (ETDEWEB)

    Rochedo, Elaine R.R.; Igreja, Eduardo; Barboza, Adriana E., E-mail: elainerochedo@gmail.com, E-mail: eduigreja@gmail.com, E-mail: adrianaebarboza@gmail.com [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil); Silva, Diogo N.G. da; Guimaraes, Jean R.D., E-mail: diogons@gmail.com, E-mail: jeanrdg@biof.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto de Biofisica Carlos Chagas Filho; Wasserman, Maria Angelica V., E-mail: mwasserman@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Perez, Daniel V. [Centro Nacional de Pesquisa de Solos (EMBRAPA), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    The assessment of remediation measures for rural areas is more complex than that for urban ones, due to the influence of large number of variables associated with climate, diet, farming practices and the type of soil. Thus, it is not possible to perform generic studies applicable to all types of area. Specific studies and surveys should be made in the areas most likely to contamination from a nuclear accident. Preliminary studies demonstrated that the different soil types in Brazil is more relevant to the ingestion dose than the regional differences in diets. Other studies have described the prioritization of areas and products for detailed survey on soil types and remediation procedures, for an accident at the NPP in Angra dos Reis, based on radiological and economic aspects. The most relevant product was milk, due to both its relevance to the intake and the loss of income for the counties. The contribution of milk to dose depends on the season of the year when the accident occurs, mainly due to the relative contribution of other items of the diet. The timing of the application of the countermeasure has an important effect on the dose reduction that can be achieved. For I-131, protective measures must be considered within the emergency phase in order to be effective. The main action on reducing ingestion doses is the removal of food items from diet, while providing clean food to the population. (author)

  7. Preliminary study on lithium-salt aqueous solution blanket

    International Nuclear Information System (INIS)

    Yoshida, Hiroshi; Naruse, Yuji; Yamaoka, Mitsuaki; Ohara, Atsushi; Ono, Kiyoshi; Kobayashi, Shigetada.

    1992-06-01

    Aqueous solution blanket using lithium salts such as LiNO 3 and LiOH have been studied in the US-TIBER program and ITER conceptual design activity. In the JAERI/LANL collaboration program for the joint operation of TSTA (Tritium Systems Test Assembly), preliminary design work of blanket tritium system for lithium ceramic blanket, aqueous solution blanket and liquid metal blanket, have been performed to investigate technical feasibility of tritium demonstration tests using the TSTA. Detail study of the aqueous solution blanket concept have not been performed in the Japanese fusion program, so that this study was carried out to investigate features of its concept and to evaluated its technical problems. The following are the major items studied in the present work: (i) Neutronics of tritium breeding ratio and shielding performance Lithium concentration, Li-60 enrichment, beryllium or lead, composition of structural material/beryllium/solution, heavy water, different lithium-salts (ii) Physicochemical properties of salts Solubility, corrosion characteristics and compatibility with structural materials, radiolysis (iii) Estimation of radiolysis in ITER aqueous solution blanket. (author)

  8. Pharmacognostic standardization and preliminary phytochemical studies of Gaultheria trichophylla.

    Science.gov (United States)

    Alam, Fiaz; Najum us Saqib, Qazi

    2015-01-01

    Gaultheria trichophylla Royle (Ericaceae) has long been used for various ailments in traditional systems of medicines; most importantly it is used against pain and inflammation. This study determines various pharmacognostic and phytochemical standards helpful to ensure the purity, safety, and efficacy of medicinal plant G. trichophylla. Intact aerial parts, powdered materials, and extracts were examined macro- and microscopically and pharmacognostic standardization parameters were determined in accordance with the guidelines given by the World Health Organization (WHO). Parameters including extractive values, ash values, and loss on drying were determined. Preliminary phytochemical tests, fluorescence analysis, and chromatographic profiling were performed for the identification and standardization of G. trichophylla. The shape, size, color, odor, and surface characteristics were noted for intact drug and powdered drug material of G. trichophylla. Light and scanning electron microscope images of cross section of leaf and powdered microscopy revealed useful diagnostic features. Histochemical, phytochemical, physicochemical, and fluorescence analysis proved useful tools to differentiate the powdered drug material. High-performance liquid chromatography (HPLC) analysis showed the presence of important phytoconstituents such as gallic acid, rutin, and quercetin. The data generated from the present study help to authenticate the medicinally important plant G. trichophylla. Qualitative and quantitative microscopic features may be helpful for establishing the pharmacopeia standards. Morphology as well as various pharmacognostic aspects of different parts of the plant were studied and described along with phytochemical and physicochemical parameters, which could be helpful in further isolation and purification of medicinally important compounds.

  9. Adult health study. Hiroshima preliminary report, 1958-1959

    Energy Technology Data Exchange (ETDEWEB)

    Hollingsworth, J W; Anderson, Jr, P S

    1961-06-28

    The first 4151 clinical examinations of radiation exposed and nonexposed persons in the Hiroshima Adult Health Study have been tabulated and reviewed. No evident differences in past history, medical symptoms, physical examination, laboratory findings, nor disease incidence could be related to the atomic radiation in 1945. The sample is small and represents only a portion of the first cycle of an examination procedure that is planned to continue indefinitely at approximately two year intervals. This report, consisting of a review of the program and the findings in this preliminary sample, includes extensive tabular data (Tables 28-65) from the coded medical information. It was not expected that radiation induced changes would be evident from this sample unless they were of unexpected prominence. The report was prepared primarily to describe the problems inherent in an epidemiologic medical study of this sort, and to review the type of data that can be obtained for future analyses. This analysis was conducted to pinpoint some of the problems; to assist others contemplating this type of medical study; to illuminate for ABCC the data that are being collected; and to suggest ways to use these data most effectively. 16 references, 1 figure, 65 tables.

  10. Caligula-Christ: Preliminary Study of a Parallel

    Directory of Open Access Journals (Sweden)

    Lorene M. Birden

    2010-01-01

    Full Text Available Caligula, at the very beginning of the Albert Camus play, conceives a very ambitious project; to surpass the gods and take their place in his empire, in order to decree impossibility. Camus has, however, gone a step further in developing the god-image of his main character through the incorporation of much Christian imagery into the scenes. This aspect of the play seems not to have been noticed by Camus scholars; there is no in-depth study of the use of this imagery. However, Camus scholar Patricia Johnson and the members of the Société des études camusiennes have noted the usefulness of the analysis presented here and the absence of it in previous research. This study, designated as “preliminary,” attempts to prompt further analyses of the question and offers different approaches. It proceeds by intertextual study of Caligula and the gospels (here referred to in Revised Standard Version and brings out aspects of the emperor’s intentions that expose a combination of perversion and similarity in relation to deity. It briefly outlines the sources of this parallel and the reasons for creating it, then details the parallels that show first the reversal of the image of Jesus, then the striking consonance. It ends with interpretations of the parallels and concludes with commentaries on the use of irony to create them.

  11. Preliminary studies to determine the shelf life of HEPA filters

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, H.; Fretthold, J.K.; Rainer, F. [Lawrence Livermore National Laboratory, CA (United States)] [and others

    1995-02-01

    We have completed a preliminary study using filter media tests and filter qualification tests to investigate the effect of shelf-life on HEPA filter performance. Our media studies showed that the tensile strength decreased with age, but the data were not sufficient to establish a shelf-life. Thermogravimetric analyses demonstrated that one manufacturer had media with low tensile strength due to insufficient binder. The filter qualification tests (heated air and overpressure) conducted on different aged filters showed that filter age is not the primary factor affecting filter performance; materials and the construction design have a greater effect. An unexpected finding of our study was that sub-standard HEPA filters have been installed in DOE facilities despite existing regulations and filter qualification tests. We found that the filter with low tensile strength failed the overpressure test. The same filter had passed the heated air test, but left the filter so structurally weak, it was prone to blow-out. We recommend that DOE initiate a filter qualification program to prevent this occurrence.

  12. Thulium-170-labeled microparticles for local radiotherapy: preliminary studies.

    Science.gov (United States)

    Polyak, Andras; Das, Tapas; Chakraborty, Sudipta; Kiraly, Reka; Dabasi, Gabriella; Joba, Robert Peter; Jakab, Csaba; Thuroczy, Julianna; Postenyi, Zita; Haasz, Veronika; Janoki, Gergely; Janoki, Gyozo A; Pillai, Maroor R A; Balogh, Lajos

    2014-10-01

    The present article describes the preparation, characterization, and biological evaluation of Thulium-170 ((170)Tm) [T1/2 = 128.4 days; Eβmax = 968 keV; Eγ = 84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. (170)Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (> 99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy.

  13. Emergent Literacy in Thai Preschoolers: A Preliminary Study.

    Science.gov (United States)

    Yampratoom, Ramorn; Aroonyadech, Nawarat; Ruangdaraganon, Nichara; Roongpraiwan, Rawiwan; Kositprapa, Jariya

    To investigate emergent literacy skills, including phonological awareness when presented with an initial phoneme-matching task and letter knowledge when presented with a letter-naming task in Thai preschoolers, and to identify key factors associated with those skills. Four hundred twelve typically developing children in their final kindergarten year were enrolled in this study. Their emergent reading skills were measured by initial phoneme-matching and letter-naming tasks. Determinant variables, such as parents' education and teachers' perception, were collected by self-report questionnaires. The mean score of the initial phoneme-matching task was 4.5 (45% of a total of 10 scores). The mean score of the letter-naming task without a picture representing the target letter name was 30.2 (68.6% of a total of 44 scores), which increased to 38.8 (88.2% of a total of 44 scores) in the letter-naming task when a picture representing the target letter name was provided. Both initial phoneme-matching and letter-naming abilities were associated with the mother's education and household income. Letter-naming ability was also influenced by home reading activities and gender. This was a preliminary study into emergent literacy skills of Thai preschoolers. The findings supported the importance of focusing on phonological awareness and phonics, especially in the socioeconomic disadvantaged group.

  14. Preliminary design studies on the Broad Application Test Reactor

    International Nuclear Information System (INIS)

    Terry, W.J.; Terry, W.K.; Ryskamp, J.M.; Jahshan, S.N.; Fletcher, C.D.; Moore, R.L.; Leyse, C.F.; Ottewitte, E.H.; Motloch, C.G.; Lacy, J.M.

    1992-08-01

    This report describes progress made at the Idaho National Engineering Laboratory during the first three quarters of Fiscal Year (FY) 1992 on the Laboratory-Directed Research and Development (LDRD) project to perform preliminary design studies on the Broad Application Test Reactor (BATR). This work builds on the FY-92 BATR studies, which identified anticipated mission and safety requirements for BATR and assessed a variety of reactor concepts for their potential capability to meet those requirements. The main accomplishment of the FY-92 BATR program is the development of baseline reactor configurations for the two conventional conceptual test reactors recommended in the FY-91 report. Much of the present report consists of descriptions and neutronics and thermohydraulics analyses of these baseline configurations. In addition, we considered reactor safety issues, compared the consequences of steam explosions for alternative conventional fuel types, explored a Molten Chloride Fast Reactor concept as an alternate BATR design, and examined strategies for the reduction of operating costs. Work planned for the last quarter of FY-92 is discussed, and recommendations for future work are also presented

  15. MR evaluation of renal function. A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Beomonte Zobel, B; Giammarile, F; Matarese, A; Gallucci, M; Mascicchi, C; Passariello, R; Di Renzi, P; Splendiani, G; Casciani, C U

    1988-01-01

    The amount of functioning renal parenchyma can be estimated by MRI by considering the ratio between the mean intensities of cortical and medullar zones of the kidney. Fifty-six patients and 5 healthy volunteers were studied by MRI in our department. Scanning was performed with a superconductive magnet system operating at 0.5 Tesla. Pulse sequence was Spin-Echo with TR 300/TE 30 ms. The cortimedullary ratio (CMR) and differentiation (CMD) were standardized and related with creatine blood levels. CMR data ranged from 1.05 to 3.00, while CMD data ranged from 0.04 to 0.50. High values (good cortico-medullary contrast) were observed in subjects with normal renal function. Patients with renal diseases had low CMR and CMD, proportionally to the degree of renal failure, as proved by laboratory findings. Our preliminary study seems to demonstrate that MRI is an useful technique in the follow-up of patients with chronic renal disease. 19 refs.

  16. Effects of gamma radiation on bee venom: preliminary studies

    International Nuclear Information System (INIS)

    Costa, H.; Boni-Mitake, M.; Souza, C.F.; Rogero, J.R.

    1999-01-01

    Africanized honeybees are very common insects in Brazil and frequently cause accidents followed by important immunological reactions and even deaths. Their venoms are composed of a complex mixture of substances of general biological actions. several works utilizing ionizing radiation showed that it is able to modify protein structures, and successfully detoxify snake venoms toxins, although maintaining its immunological properties. The main objective of this paper was to study the effects of gamma radiation on bee venom, regarding some biochemical and toxicological aspects. Africanized Apis melllifera whole venom (2 mg/ml) in 0.15 M Na Cl solution was irradiated with 2 kGy in a 60 Co source. Preliminary studies has been carried out in order to identify some biochemical changes after irradiation. Concerning this, irradiated and native venom were submitted to a molecular exclusion chromatography (Sephadex G-100), UV absorption spectrum and protein concentration analysis. It could be seen that irradiated bee venom spectrum presented differences when compared to native bee venom, suggesting that some structural alterations has occurred. Protein concentration and chromatography profiles were not changes after irradiation. In order to evaluate the toxicity a lethality assay (L D 50 ) has been performed with both venoms, and irradiated venom showed to be less toxic than native one. (author)

  17. Intraarterial Ultrasound in Pancreatic Cancer: Feasibility Study and Preliminary Results

    International Nuclear Information System (INIS)

    Larena-Avellaneda, Axel; Timm, Stephan; Kickuth, Ralph; Kenn, Werner; Steger, Ulrich; Jurowich, Christian; Germer, Christoph-Thomas

    2010-01-01

    Despite technological advances in computed tomography (CT) and magnetic resonance imaging, the involvement of the celiac or mesenteric artery in pancreatic cancer remains uncertain in many cases. Infiltration of these vessels is important in making decisions about therapy choices but often can only be definitively determined through laparotomy. Local (intraarterial) ultrasound may increase diagnostic accuracy. Using the Volcano intravascular ultrasound (IVUS) system, we applied a transfemoral method to scan the celiac and mesenteric arteries directly intraarterial. This technique was used in five patients with suspected pancreatic cancer. Technical success was achieved in all cases. In one case, a short dissection of the mesenteric artery occurred but could be managed interventionally. In tumors that did not contact with the vessels, IVUS was unable to display the tissue pathology. Our main interest was the infiltration of the arteries. In one case, infiltration was certain in the CT scan but uncertain in two patients. In the latter two cases, IVUS correctly predicted infiltration in one and freedom from tumor in the other case. In our preliminary study, IVUS correctly predicted arterial infiltration in all cases. IVUS did not provide new information when the tumor was far away from the vessel. Compared with IVUS in the portal vein, the information about the artery is more detailed, and the vessel approach is easier. These results encouraged us to design a prospective study to evaluate the sensitivity and specificity of this method.

  18. Effects of gamma radiation on bee venom: preliminary studies

    Energy Technology Data Exchange (ETDEWEB)

    Costa, H.; Boni-Mitake, M.; Souza, C.F.; Rogero, J.R. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Div. de Radiobiologia

    1999-11-01

    Africanized honeybees are very common insects in Brazil and frequently cause accidents followed by important immunological reactions and even deaths. Their venoms are composed of a complex mixture of substances of general biological actions. several works utilizing ionizing radiation showed that it is able to modify protein structures, and successfully detoxify snake venoms toxins, although maintaining its immunological properties. The main objective of this paper was to study the effects of gamma radiation on bee venom, regarding some biochemical and toxicological aspects. Africanized Apis melllifera whole venom (2 mg/ml) in 0.15 M Na Cl solution was irradiated with 2 kGy in a {sup 60} Co source. Preliminary studies has been carried out in order to identify some biochemical changes after irradiation. Concerning this, irradiated and native venom were submitted to a molecular exclusion chromatography (Sephadex G-100), UV absorption spectrum and protein concentration analysis. It could be seen that irradiated bee venom spectrum presented differences when compared to native bee venom, suggesting that some structural alterations has occurred. Protein concentration and chromatography profiles were not changes after irradiation. In order to evaluate the toxicity a lethality assay (L D{sub 50}) has been performed with both venoms, and irradiated venom showed to be less toxic than native one. (author) 23 refs., 3 figs., 1 tab.

  19. Pathology of gastric lesions in donkeys: A preliminary study.

    Science.gov (United States)

    Al-Mokaddem, A K; Ahmed, K A; Doghaim, R E

    2015-11-01

    Donkeys (Equus africanus asinus) are important working animals, particularly in countries where the majority of the population lives below the poverty line. Gastric ulceration has been shown to be common in British donkeys but donkeys from other parts of the world have not been as extensively researched. This study was performed as a preliminary overview of the severity and distribution of gastric lesions in mature donkeys and to document which parasites were present. Descriptive study of pathological findings. Stomachs of 35 mature draught donkeys were examined grossly and histopathology samples taken from 5 regions of the gastric mucosa. Gross examination revealed hyperaemia, oedema, erosions and ulcers in addition to parasitic lesions. Histopathological examination revealed hyperkeratosis, acanthosis, vacuolar degeneration of stratified squamous cells, gastritis, erosions, ulcerations, scarring, hyperactivity of mucus glands, periglandular fibroplasia and parasitic granulomes with infestation by Gasterophilus spp. larvae, Habronema spp. and Draschia megastoma. In donkeys, ulceration of the nonglandular regions of the stomach is more prominent than the glandular regions and parasitic infestations were frequent. © 2014 EVJ Ltd.

  20. Hypoallergenic properties of donkey's milk: a preliminary study

    Directory of Open Access Journals (Sweden)

    Silvia Vincenzetti

    2014-06-01

    Full Text Available Cow's milk protein allergy (CMPA is an abnormal immunological response to cow milk proteins, which results in IgE-mediated reactions. The therapeutic strategy to respond to CMPA envisages the total elimination of milk or the administration of cow's milk substitutes. For this reason the use of milk from other mammalian species was tested. Among them, donkey's milk proved to be the best alternative in feeding infants affected by CMPA, since its chemical composition is comparable to human milk. In this work an in vitro study was performed in order to analyze the IgE reactivity to milk protein allergens from cow, donkey and goat. In particular, immunoblotting experiments using sera from milk-allergic and non-allergic adult volunteers were conducted with the aim of verifying the hypoallergenic property of donkey's milk. This study provided a preliminary evidence of the hypoallergenicity of donkey's milk when compared to bovine and goat milk. Considering the obtained results, it would be possible to develop a sensitive diagnostic method for CMPA detection, based on chromatographic and immunoblotting analysis.

  1. Wastewater characterization of IPEN facilities - a preliminary study

    International Nuclear Information System (INIS)

    Monteiro, Lucilena R.; Goncalves, Cristina; Terazan, Wagner R.; Cotrim, Marycel E.B.; Pires, Maria Aparecida F.

    2011-01-01

    As part of IPEN's Environmental Monitoring Program, wastewater sample collection and analysis was implemented on a daily basis. CQMA- Centro de Quimica e Meio Ambiente was responsible for the determination of total, fixed and volatile solids, pH, metals (as Al, Sb, Ba, Cd, Pb, Co, Cu, Cr, Hg, Mo, Ni, Ag, Na, Zn, Ca, Mg, Be, Sn, Li, K, Sr, Ti and V), semimetals (As, B, Se and Si) and anions (such as chloride, nitrate, sulfate and fluoride). The results were compared to the legal values established by the Sao Paulo State regulation 8,468/76, which defines the maximum permitted values for most of the studied substances in wastewater, aiming its releasing in public wastewater treatment system. The evaluation of this parameters concentration on Ipen's effluent implies that 50% of the wastewater corresponds to organic matter due to the sanitary load and inorganic macro elements, mainly as sodium, potassium, calcium. The only parameter not found in accordance with Brazilian legislation was pH in four out of the one hundred and seven samples collected throughout 2009 (2.8% of the samples analyzed). This preliminary study showed the effluents generated at Ipen's facility is characterized by the presence of organic matter and macro elements, commonly found in sanitary wastewater and it is in compliance with Sao Paulo regulations. (author)

  2. Gasoline on hands: preliminary study on collection and persistence.

    Science.gov (United States)

    Darrer, Melinda; Jacquemet-Papilloud, Joëlle; Delémont, Olivier

    2008-03-05

    The identification of an arsonist remains one of the most difficult challenges a fire investigation has to face. Seeking and detection of traces of gasoline could provide a valuable information to link a suspect with an arson scene where gasoline was used to set-up the fire. In this perspective, a first study was undertaken to evaluate a simple, fast and efficient method for collecting gasoline from hands, and to assess its persistence over time. Four collection means were tested: PVC, PE and Latex gloves, as well as humidified filter paper. A statistical assessment of the results indicates that Latex and PVC gloves worn for about 20 min, as well as paper filter rubbed on hands, allow an efficient collection of gasoline applied to hands. Due to ease of manipulation and to a reduced amount of volatile compounds detected from the matrix, PVC gloves were selected for the second set of experiments. The evaluation of the persistence of gasoline on hands was then carried out using two initial quantities (500 and 1000 microl). Collection was made with PVC gloves after 0, 30 min, 1, 2 and 4h, on different volunteers. The results show a common tendency of massive evaporation of gasoline during the first 30 min: a continued but non-linear decrease was observed along different time intervals. The results of this preliminary study are in agreement with other previous researches conducted on the detection of flammable liquid residues on clothes, shoes and skin.

  3. Development of the Music Therapy Assessment Tool for Advanced Huntington's Disease: A Pilot Validation Study.

    Science.gov (United States)

    O'Kelly, Julian; Bodak, Rebeka

    2016-01-01

    Case studies of people with Huntington's disease (HD) report that music therapy provides a range of benefits that may improve quality of life; however, no robust music therapy assessment tools exist for this population. Develop and conduct preliminary psychometric testing of a music therapy assessment tool for patients with advanced HD. First, we established content and face validity of the Music Therapy Assessment Tool for Advanced HD (MATA-HD) through focus groups and field testing. Second, we examined psychometric properties of the resulting MATA-HD in terms of its construct validity, internal consistency, and inter-rater and intra-rater reliability over 10 group music therapy sessions with 19 patients. The resulting MATA-HD included a total of 15 items across six subscales (Arousal/Attention, Physical Presentation, Communication, Musical, Cognition, and Psychological/Behavioral). We found good construct validity (r ≥ 0.7) for Mood, Communication Level, Communication Effectiveness, Choice, Social Behavior, Arousal, and Attention items. Cronbach's α of 0.825 indicated good internal consistency across 11 items with a common focus of engagement in therapy. The inter-rater reliability (IRR) Intra-Class Coefficient (ICC) scores averaged 0.65, and a mean intra-rater ICC reliability of 0.68 was obtained. Further training and retesting provided a mean of IRR ICC of 0.7. Preliminary data indicate that the MATA-HD is a promising tool for measuring patient responses to music therapy interventions across psychological, physical, social, and communication domains of functioning in patients with advanced HD. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Preliminary studies in rice-fish culture in a rainfed lowland ecology ...

    African Journals Online (AJOL)

    Preliminary studies in rice-fish culture in a rainfed lowland ecology in Ghana. PKA Dartey, RK Bam, J Ofori. Abstract. Mixed farms of rice and fish are yet to receive attention in Ghana, despite lowland rice being grown under inundation in most areas nationwide. In a preliminary study, Nile tilapia (Oreochromis niloticus) was ...

  5. A Preliminary Study of Sex Differences in Emotional Experience.

    Science.gov (United States)

    Reyes-Aguilar, Azalea; Barrios, Fernando A

    2016-04-01

    Evolutionary approaches have proposed that women possess an advantage over men in emotional functioning to promote attachment for child-rearing. Likewise, sex differences have been reported in traits such as personality and empathy, traits that likely modulate emotional processing. In this preliminary study, sex differences in emotional processing were analyzed, including empathy as a social emotion and personality traits, as well as whether there exist relationships between those measures. Young volunteers (N = 105) indicated the emotional valence, activation, and dominance that they experience in situations categorized as emotionally positive, negative, or neutral. The results of comparison between sexes supported the approach that women showed more sensitivity to high activation and dominance for positive emotions and empathy, and men were more sensitive to negative situations. Correlation analysis showed only one positive relationship between scores of Self-transcendence, a subscale of Temperament and Character Inventory, with activation scores of neutral situations, but not with emotionally charged situations, perhaps because emotions are context-dependent processes while personality traits are considered context-independent descriptions of habits. These findings should be replicated to enrich knowledge about problems in emotional processing. © The Author(s) 2016.

  6. Textual appropriation in engineering master's theses: a preliminary study.

    Science.gov (United States)

    Eckel, Edward J

    2011-09-01

    In the thesis literature review, an engineering graduate student is expected to place original research in the context of previous work by other researchers. However, for some students, particularly those for whom English is a second language, the literature review may be a mixture of original writing and verbatim source text appropriated without quotations. Such problematic use of source material leaves students vulnerable to an accusation of plagiarism, which carries severe consequences. Is such textual appropriation common in engineering master's writing? Furthermore, what, if anything, can be concluded when two texts have been found to have textual material in common? Do existing definitions of plagiarism provide a sufficient framework for determining if an instance of copying is transgressive or not? In a preliminary attempt to answer these questions, text strings from a random sample of 100 engineering master's theses from the ProQuest Dissertations and Theses database were searched for appropriated verbatim source text using the Google search engine. The results suggest that textual borrowing may indeed be a common feature of the master's engineering literature review, raising questions about the ability of graduate students to synthesize the literature. The study also illustrates the difficulties of making a determination of plagiarism based on simple textual similarity. A context-specific approach is recommended when dealing with any instance of apparent copying.

  7. Preliminary Design Study of the Hollow Electron Lens for LHC

    CERN Document Server

    Perini, Diego; CERN. Geneva. ATS Department

    2017-01-01

    A Hollow Electron Lens (HEL) has been proposed in order to improve performance of halo control and collimation in the Large Hadron Collider in view of its High Luminosity upgrade (HL-LHC). The concept is based on a beam of electrons that travels around the protons for a few meters. The electron beam is produced by a cathode and then guided by a strong magnetic field generated by a set of superconducting solenoids. The first step of the design is the definition of the magnetic fields that drive the electron trajectories. The estimation of such trajectories by means of a dedicated MATLAB® tool is presented. The influence of the main geometrical and electrical parameters are analysed and discussed. Then, the main mechanical design choices for the solenoids, cryostats gun and collector are described. The aim of this paper is to provide an overview of the preliminary design of the Electron Lens for LHC. The methods used in this study also serve as examples for future mechanical and integration designs of similar ...

  8. Primary contraction of skin grafts: a porcine preliminary study

    Directory of Open Access Journals (Sweden)

    Alexander Bogdanov Berezovsky

    2015-03-01

    Full Text Available Aim: Skin grafting is a common clinical practice for plastic surgeons, yet primary contraction of these grafts is a neglected topic. This study was designed to investigate primary contraction and introduce the shape of skin graft as a possible factor that modifies primary contraction behavior, using porcine models. Methods: In the first series, full-thickness skin grafts (FTSGs and split-thickness skin grafts (STSGs were compared. In a second series, how the shape of the skin graft affected the degree of contraction was examined. Results: The mean percentage of FTSG shrinkage was 12.04%, and the median was 12.18%. The mean percentage of STSG shrinkage was 6.87%, and the median was 5%. Circle-shaped and square-shaped FTSGs showed mean/median graft shrinkage of 5.83%/6.93% and 4.15%/3.75%, respectively. In STSGs, the circle-shaped and square-shaped grafts had mean/median graft shrinkage of 1.07%/0% and 0.31%/0%, respectively. Conclusion: Our preliminary report revealed an expected greater shrinkage of FTSGs compared with STSGs. Furthermore, in a limited number of specimens, the shape of the skin graft seemed to affect the primary contraction of the STSGs.

  9. Real-time trichromatic holographic interferometry: preliminary study

    Science.gov (United States)

    Albe, Felix; Bastide, Myriam; Desse, Jean-Michel; Tribillon, Jean-Louis H.

    1998-08-01

    In this paper we relate our preliminary experiments on real- time trichromatic holographic interferometry. For this purpose a CW `white' laser (argon and krypton of Coherent- Radiation, Spectrum model 70) is used. This laser produces about 10 wavelengths. A system consisting of birefringent plates and polarizers allows to select a trichromatic TEM00 triplet: blue line ((lambda) equals 476 nm, 100 mW), green line ((lambda) equals 514 nm, 100 mW) and red line ((lambda) equals 647 nm, 100 mW). In a first stage we recorded a trichromatic reflection hologram with a separate reference beam on a single-layer silver-halide panchromatic plate (PFG 03C). After processing, the hologram is put back into the original recording set-up, as in classical experiments on real-time monochromatic holographic interferometry. So we observe interference fringes between the 3 reconstructed waves and the 3 actual waves. The interference fringes of the phenomenon are observed on a screen and recorded by a video camera at 25 frames per second. A color video film of about 3 minutes of duration is presented. Some examples related to phase objects are presented (hot airflow from a candle, airflow from a hand). The actual results show the possibility of using this technique to study, in real time, aerodynamic wakes and mechanical deformation.

  10. ECG response of koalas to tourists proximity: a preliminary study.

    Directory of Open Access Journals (Sweden)

    Yan Ropert-Coudert

    Full Text Available Koalas operate on a tight energy budget and, thus, may not always display behavioral avoidance reaction when placed in a stressful condition. We investigated the physiological response of captive koalas Phascolarctos cinereus in a conservation centre to the presence of tourists walking through their habitat. We compared, using animal-attached data-recorders, the electrocardiogram activity of female koalas in contact with tourists and in a human-free area. One of the koalas in the tourist zone presented elevated heart rate values and variability throughout the recording period. The remaining female in the exhibit area showed a higher field resting heart rates during the daytime than that in the isolated area. In the evening, heart rate profiles changed drastically and both the koalas in the exhibit and in the tourist-free zones displayed similar field resting heart rates, which were lower than those during the day. In parallel, the autonomic nervous systems of these two individuals evolved from sympathetic-dominant during the day to parasympathetic-dominant in the evening. Our results report ECG of free-living koalas for the first time. Although they are preliminary due to the difficulty of having sufficient samples of animals of the same sex and age, our results stress out the importance of studies investigating the physiological reaction of animals to tourists.

  11. [Resilience in caregivers of patients with dementia: A preliminary study].

    Science.gov (United States)

    Fernández-Lansac, Violeta; Crespo López, María; Cáceres, Rebeca; Rodríguez-Poyo, María

    2012-01-01

    Caring for a relative with dementia often has negative effects on the caregiver's physical and psychological health. However, many caregivers successfully cope with the stress factors arising from care, and even have uplifts during their experience, showing high resilience levels. This study presents a preliminary analysis of resilience in caregivers of patients with dementia, exploring its relationship with different variables. Resilience was assessed (by CD-RISC) in 53 family caregivers of patients with dementia. Resilience was correlated to the following variables: caregiving context, stressors (e.g., cognitive impairment), appraisals (e.g., burden), moderators (e.g., personality traits and resources), and caregiving consequences (physical and psychological health). The participants showed moderate scores on resilience. Resilience was associated with poor emotional and physical status (significant inverse correlations with anxiety, depression, psycho-active drug use, health habits…). High resilience scores were significantly correlated to burden, neuroticism and extraversion, self-efficacy, self-esteem and less use of emotion focused coping strategies. Higher resilience relates to a good emotional and physical status in caregivers. Moreover, resilience is more associated with caregiver variables (e.g., appraisal and coping with care, personality features), than to situational variables. The data highlight the strengthening of these types of appraisal and coping as a way to improve caregivers' resilience and, consequently, their health. Copyright © 2011 SEGG. Published by Elsevier Espana. All rights reserved.

  12. Bio-Contamination Control for Spacesuit Garments - A Preliminary Study

    Science.gov (United States)

    Rhodes, Richard; Korona, Adam; Orndoff, Evelyn; Ott, Mark; Poritz, Darwin

    2010-01-01

    This paper outlines a preliminary study to review, test, and improve upon the current state of spacesuit bio-contamination control. The study includes an evaluation of current and advanced suit materials, ground and on-orbit cleaning methods, and microbial test and analysis methods. The first aspect of this study was to identify potential anti-microbial textiles and cleaning agents, and to review current microbial test methods. The anti-microbial cleaning agent and textile market survey included a review of current commercial-off-the-shelf (COTS) products that could potentially be used as future space flight hardware. This review included replacements for any of the softgood layers that may become contaminated during an extravehicular activity (EVA), including the pressure bladder, liquid cooling garment, and ancillary comfort undergarment. After a series of COTS anti-microbial textiles and clean ing agents were identified, a series of four tests were conducted: (1) a stacked configuration test that was conducted in order to review how bio-contamination would propagate through the various suit layers, (2) a individual materials test that evaluated how well each softgood layer either promoted or repressed growth, (3) a cleaning agent test that evaluated the efficacy on each of the baseline bladders, and (4) an evaluation of various COTS anti-microbial textiles. All antimicrobial COTS materials tested appeared to control bacteria colony forming unit (CFU) growth better than the Thermal Comfort Undergarment (TCU) and ACES Liquid Cooling Garment (LCG)/EMU Liquid Cooling Ventilation Garment (LCVG) materials currently in use. However, a comparison of fungi CFU growth in COTS to current suit materials appeared to vary per material. All cleaning agents tested in this study appeared to inhibit the level of bacteria and fungi growth to acceptable levels for short duration tests. While several trends can be obtained from the current analysis, a series of test improvements are

  13. A preliminary magnetic study of Sawa lake sediments, Southern Iraq

    Science.gov (United States)

    Ameen, Nawrass

    2016-04-01

    A preliminary magnetic study combined with chemical analyses was carried out in Sawa Lake in Al-Muthanna province, southern Iraq, about 22 km south west of Samawa city (31°18'48.80"N, 45°0'25.25"E). The lake is about 4.74 km length, 1.75 km width and 5.5 m height, it is surrounded by a salt rim which is higher than the lake water by about 2.8 m and sea water by about 18.5 m (Naqash et al., 1977 in Hassan, 2007). The lake is an elongated closed basin with no surface water available to it, it may be fed by groundwater of the Euphrates and Dammam aquifers through system of joints and cracks. This study aims to investigate the concentrations of selected heavy metals as pollutants and magnetic susceptibility (MS) and other magnetic properties of sediment samples from fifty sites collected from the bottom of the lake, the study area lies in an industrial area. The results show spatial variations of MS with mean value of about 4.58 x 10-8 m3 kg-1. Scanning electron microscopy and magnetic mineralogy parameters indicate the dominance of soft magnetic phase like magnetite and presence of hard magnetic phase like hematite. Spatial variations of MS combined with the concentrations of heavy metals suggests the efficiency of magnetic methods as effective, inexpensive and non-time consuming method to outlining the heavy metal pollution. References: Hassan W.F., 2007. The Physio-chemical characteristic of Sawa lake water in Samawa city-Iraq. Marine Mesopotamica, 22(2), 167-179.

  14. Progress in preliminary studies at Ottana Solar Facility

    Science.gov (United States)

    Demontis, V.; Camerada, M.; Cau, G.; Cocco, D.; Damiano, A.; Melis, T.; Musio, M.

    2016-05-01

    The fast increasing share of distributed generation from non-programmable renewable energy sources, such as the strong penetration of photovoltaic technology in the distribution networks, has generated several problems for the management and security of the whole power grid. In order to meet the challenge of a significant share of solar energy in the electricity mix, several actions aimed at increasing the grid flexibility and its hosting capacity, as well as at improving the generation programmability, need to be investigated. This paper focuses on the ongoing preliminary studies at the Ottana Solar Facility, a new experimental power plant located in Sardinia (Italy) currently under construction, which will offer the possibility to progress in the study of solar plants integration in the power grid. The facility integrates a concentrating solar power (CSP) plant, including a thermal energy storage system and an organic Rankine cycle (ORC) unit, with a concentrating photovoltaic (CPV) plant and an electrical energy storage system. The facility has the main goal to assess in real operating conditions the small scale concentrating solar power technology and to study the integration of the two technologies and the storage systems to produce programmable and controllable power profiles. A model for the CSP plant yield was developed to assess different operational strategies that significantly influence the plant yearly yield and its global economic effectiveness. In particular, precise assumptions for the ORC module start-up operation behavior, based on discussions with the manufacturers and technical datasheets, will be described. Finally, the results of the analysis of the: "solar driven", "weather forecasts" and "combined storage state of charge (SOC)/ weather forecasts" operational strategies will be presented.

  15. Nevada potential repository preliminary transportation strategy: Study 1

    International Nuclear Information System (INIS)

    1995-04-01

    Limited feasible options exist when considering the shipment of spent nuclear fuel and high-level radioactive waste. These options are rail or truck; because of the weight associated with transportation casks (68.0 to 113.4 tonnes/75 to 125 tons), heavy-haul trucks are also considered. Yucca Mountain currently lacks rail service or an existing right-of-way for rail; it also lacks a dedicated highway suitable for heavy-haul trucks. Approximately 11,230 shipments by rail are planned from waste producer sites to Nevada, with an additional 1,041 shipments by legal-weight truck from four reactor sites not capable of upgrading for rail shipment. This study identifies the reasonable alternatives for waste transport to the potential repository site, describes the evaluation process performed to identify those alternatives, and discusses the reasons for elimination of transportation routes deemed to be not reasonable. The study concluded that heavy haul truck transportation is feasible-cost is very favorable when compared to rail-but route restrictions must be further evaluated. In addition to restrictions due to seasonal weather conditions, specific routes have additional restrictions, including no travel on holidays or weekends, and travel during daylight hours only. Further restrictions will be imposed by the U.S. Department of Transportation based on routing of radioactive materials by highway. Operation and maintenance costs for heavy-haul over a 24-year period, based on preliminary information, were calculated on an estimated operational cost of $15,000 per trip, with an estimated 468 trips per year average (11,230 total trips), for an estimated cost of $171 million to $173 million, depending on the route used. Because the initial costs and the total system life cycle costs of heavy-haul are approximately 50 percent lower than the lowest rail cost, this option will continue to be evaluated

  16. Preliminary study of percutaneous nephrolithotomy on an ambulatory basis.

    Science.gov (United States)

    El-Tabey, Magdy Ahmed; Abd-Allah, Osama Abdel-Wahab; Ahmed, Ahmed Sebaey; El-Barky, Ehab Mohammed; Noureldin, Yasser Abdel-Sattar

    2013-02-01

    Preliminary study to assess the feasibility and safety of percutaneous nephrolithotomy (PCNL) as an ambulatory procedure. Between February 2011 and September 2012, 84 patients with renal calculi fulfilling the inclusion criteria were admitted to the Urology Department of Benha University Hospitals for PCNL. All patients were subjected to a full medical history, clinical, laboratory and radiological examinations. Tubeless PCNLs were done in the supine position, and an antegrade double-J stent was inserted. Operative time and intraoperative complications were recorded. Postoperatively, the hematocrit value, postoperative pain and analgesics, need of blood transfusion, stone-free rate, and length of hospital stay were recorded. Stable patients that could be safely discharged within 24 hours after surgery were considered ambulatory. All cases of tubeless PCNL were successfully done and no cases converted to open surgery. The overall stone-free rate was 91.7%, the mean postoperative pain score measured by the visual analog scale was 4.4 ± 1.2, the mean overall hematocrit deficit was 4.8 ± 2.2% and the mean hospital stay was 33.4 ± 17.5 hours. Ambulatory PCNL was accomplished in 60 out of 84 patients (71.4%) and double-J stents were removed 7-10 days postoperatively. In the non-ambulatory cases, double-J stents were removed after auxillary procedures were done according to each case. PCNL can be safely done on an ambulatory basis under strict criteria, but further studies are needed to confirm and expand these findings.

  17. Nevada potential repository preliminary transportation strategy: Study 1

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1995-04-01

    Limited feasible options exist when considering the shipment of spent nuclear fuel and high-level radioactive waste. These options are rail or truck; because of the weight associated with transportation casks (68.0 to 113.4 tonnes/75 to 125 tons), heavy-haul trucks are also considered. Yucca Mountain currently lacks rail service or an existing right-of-way for rail; it also lacks a dedicated highway suitable for heavy-haul trucks. Approximately 11,230 shipments by rail are planned from waste producer sites to Nevada, with an additional 1,041 shipments by legal-weight truck from four reactor sites not capable of upgrading for rail shipment. This study identifies the reasonable alternatives for waste transport to the potential repository site, describes the evaluation process performed to identify those alternatives, and discusses the reasons for elimination of transportation routes deemed to be not reasonable. The study concluded that heavy haul truck transportation is feasible-cost is very favorable when compared to rail-but route restrictions must be further evaluated. In addition to restrictions due to seasonal weather conditions, specific routes have additional restrictions, including no travel on holidays or weekends, and travel during daylight hours only. Further restrictions will be imposed by the U.S. Department of Transportation based on routing of radioactive materials by highway. Operation and maintenance costs for heavy-haul over a 24-year period, based on preliminary information, were calculated on an estimated operational cost of $15,000 per trip, with an estimated 468 trips per year average (11,230 total trips), for an estimated cost of $171 million to $173 million, depending on the route used. Because the initial costs and the total system life cycle costs of heavy-haul are approximately 50 percent lower than the lowest rail cost, this option will continue to be evaluated.

  18. In vivo radioprotection by alpha-TMG: preliminary studies.

    Science.gov (United States)

    Satyamitra, M; Devi, P U; Murase, H; Kagiya, V T

    2001-08-08

    alpha-TMG is a novel water-soluble derivative of Vitamin E that has shown excellent antioxidant activity. The parent compound has demonstrated protection against radiation induced chromosomal damage in vivo. Hence, the preliminary experiments to determine the radioprotective activity of alpha-TMG were carried out in adult Swiss albino mice. Acute toxicity of the drug was studied taking 24h, 72 h and 30 day mortality after a single intraperitoneal injection of 500-2000 mg/kg body weight of the drug. The drug LD(50) for 24h and 72 h/30 day survival were found to be 1120 and 1000 mg/kg body weight, respectively. The optimum time of drug administration and drug dose-dependent effect on in vivo radiation protection of bone marrow chromosomes was studied in mice. Injection of 600 mg/kg of the drug 15 min before or within 5, 15 or 30min after 3Gy whole body gamma radiation resulted in a significant decrease in the aberrant metaphases percent at 24h post-irradiation; the maximum effect was seen when the drug was given immediately after irradiation. Injection of 200-800 mg/kg TMG within 5 min of irradiation with 3 Gy produced a significant dose-dependent reduction in the radiation induced percent aberrant metaphases and in the frequency of micronucleated erythrocytes at 24h after exposure, with a corresponding decrease in the different types of aberrations. The optimum dose for protection without drug toxicity was 600 mg/kg body weight. At this dose, TMG produced 70 and >60% reduction in the radiation induced percent aberrant metaphases and micronucleated erythrocytes, respectively. The high water solubility and effectiveness when administered post-irradiation favor TMG as a likely candidate for protection in case of accidental exposures.

  19. Bioactivities in the tamarind seed extracts: A preliminary study

    Science.gov (United States)

    Garg, Sukant; Muangman, Thanchanok; Huifu, He; Ling, Li; Kaul, Sunil C.; Wadhwa, Renu

    2018-01-01

    Stress is a state that triggers change in normal physiology and recognized by human body and brain as an unfavorable event causing concern, worry or anxiety. It may vary from physical, metabolic, physiological or emotional often culminating into wide range of ailments that may range from common cold, decline in functional efficacy of body systems or even cancer. Skin is the largest tissue of the body and makes the first interface with the environment. Skin color and characteristics are highly influenced by environment stress. A variety of natural compounds have been used for anti-stress and disease preventive potentials in worldwide traditional home medicine systems. They have recently attracted attention in research laboratories to dissect their mode of action to promote safe and economic drug development. We have earlier identified anti-stress and anti-aging activities in Withania somnifera, Helicteres angustifolia and honeybee propolis using human cultured normal and cancer cells. In the present study, we explored the effect of tamarind seed extracts prepared in water or 95% ethanol. In cell-based assays, we found that the extracts were safe to use in viable cells (in the range of 0.01-1.0%, for at least 4 weeks). Consistently, molecular studies revealed no effect on the expression/activity of cancer promoting proteins. We recruited oxidative stress models, such as, hydrogen peroxide (H2O2), ultraviolet radiation (UV) and diacylglycerol 1-oleoyl-2-acetyl-sn-glycerol (OAG). Investigation on anti-stress potential of the extracts revealed that they do not offer remarkable protection against stress caused by either H2O2 or UV, however, significantly compromised OAG-induced melanogenesis. The preliminary data warrant further investigations on the active components and mechanism of action to develop useful natural compounds/extracts for manipulation of melanogenesis that plays important role in response of cells to UV and its consequences including DNA damage

  20. Preliminary studies on the behavioural effects of the methanol ...

    African Journals Online (AJOL)

    The behavioural tests employed were diazepam-induced sleep onset and duration, hole board assay for exploratory activity, mouse beam walk assay for motor coordination, and the staircase test for the detection of anxiolytic compounds. Preliminary phytochemical screening was also carried out on the extract. Results: The ...

  1. Preliminary study of radioactive waste disposal in granitic underground caves

    International Nuclear Information System (INIS)

    Carvalho, J.F. de; Carajilescov, P.

    1984-01-01

    To date, the disposal of radioactive wastes is one of the major problems faced by the nuclear industry. The utilization of granitic underground caves surrounded by a clay envelope is suggested as a safe alternative for such disposal. A preliminary analysis of the dimensions of those deposits is done. (Author) [pt

  2. A Preliminary Study on Cathodic Prevention in Reinforced Mortar

    NARCIS (Netherlands)

    Koleva, D.A.; Van Breugel, K.; Mol, J.M.C.; De Wit, J.H.W.

    2010-01-01

    This work presents the preliminary tests on the performance of cathodic prevention (CPre) in reinforced mortar, subjected to aggressive (10% NaCl environment). Cathodic prevention is an electrochemical technique for minimizing, actually "preventing" any eventual corrosion of the steel bars in

  3. Preliminary study for small animal preclinical hadrontherapy facility

    Energy Technology Data Exchange (ETDEWEB)

    Russo, G. [Institute of Molecular Bioimaging and Physiology, IBFM CNR-LATO, Cefalú (Italy); Pisciotta, P., E-mail: pietro.pisciotta@ibfm.cnr.it [Institute of Molecular Bioimaging and Physiology, IBFM CNR-LATO, Cefalú (Italy); National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania (Italy); Cirrone, G.A.P.; Romano, F. [National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania (Italy); Cammarata, F.; Marchese, V.; Forte, G.I.; Lamia, D.; Minafra, L.; Bravatá, V. [Institute of Molecular Bioimaging and Physiology, IBFM CNR-LATO, Cefalú (Italy); Acquaviva, R. [University of Catania, Catania (Italy); Gilardi, M.C. [Institute of Molecular Bioimaging and Physiology, IBFM CNR-LATO, Cefalú (Italy); Cuttone, G. [National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania (Italy)

    2017-02-21

    Aim of this work is the study of the preliminary steps to perform a particle treatment of cancer cells inoculated in small animals and to realize a preclinical hadrontherapy facility. A well-defined dosimetric protocol was developed to explicate the steps needed in order to perform a precise proton irradiation in small animals and achieve a highly conformal dose into the target. A precise homemade positioning and holding system for small animals was designed and developed at INFN-LNS in Catania (Italy), where an accurate Monte Carlo simulation was developed, using Geant4 code to simulate the treatment in order to choose the best animal position and perform accurately all the necessary dosimetric evaluations. The Geant4 application can also be used to realize dosimetric studies and its peculiarity consists in the possibility to introduce the real target composition in the simulation using the DICOM micro-CT image. This application was fully validated comparing the results with the experimental measurements. The latter ones were performed at the CATANA (Centro di AdroTerapia e Applicazioni Nucleari Avanzate) facility at INFN-LNS by irradiating both PMMA and water solid phantom. Dosimetric measurements were performed using previously calibrated EBT3 Gafchromic films as a detector and the results were compared with the Geant4 simulation ones. In particular, two different types of dosimetric studies were performed: the first one involved irradiation of a phantom made up of water solid slabs where a layer of EBT3 was alternated with two different slabs in a sandwich configuration, in order to validate the dosimetric distribution. The second one involved irradiation of a PMMA phantom made up of a half hemisphere and some PMMA slabs in order to simulate a subcutaneous tumour configuration, normally used in preclinical studies. In order to evaluate the accordance between experimental and simulation results, two different statistical tests were made: Kolmogorov test and

  4. Preliminary study for small animal preclinical hadrontherapy facility

    Science.gov (United States)

    Russo, G.; Pisciotta, P.; Cirrone, G. A. P.; Romano, F.; Cammarata, F.; Marchese, V.; Forte, G. I.; Lamia, D.; Minafra, L.; Bravatá, V.; Acquaviva, R.; Gilardi, M. C.; Cuttone, G.

    2017-02-01

    Aim of this work is the study of the preliminary steps to perform a particle treatment of cancer cells inoculated in small animals and to realize a preclinical hadrontherapy facility. A well-defined dosimetric protocol was developed to explicate the steps needed in order to perform a precise proton irradiation in small animals and achieve a highly conformal dose into the target. A precise homemade positioning and holding system for small animals was designed and developed at INFN-LNS in Catania (Italy), where an accurate Monte Carlo simulation was developed, using Geant4 code to simulate the treatment in order to choose the best animal position and perform accurately all the necessary dosimetric evaluations. The Geant4 application can also be used to realize dosimetric studies and its peculiarity consists in the possibility to introduce the real target composition in the simulation using the DICOM micro-CT image. This application was fully validated comparing the results with the experimental measurements. The latter ones were performed at the CATANA (Centro di AdroTerapia e Applicazioni Nucleari Avanzate) facility at INFN-LNS by irradiating both PMMA and water solid phantom. Dosimetric measurements were performed using previously calibrated EBT3 Gafchromic films as a detector and the results were compared with the Geant4 simulation ones. In particular, two different types of dosimetric studies were performed: the first one involved irradiation of a phantom made up of water solid slabs where a layer of EBT3 was alternated with two different slabs in a sandwich configuration, in order to validate the dosimetric distribution. The second one involved irradiation of a PMMA phantom made up of a half hemisphere and some PMMA slabs in order to simulate a subcutaneous tumour configuration, normally used in preclinical studies. In order to evaluate the accordance between experimental and simulation results, two different statistical tests were made: Kolmogorov test and

  5. Preliminary study for small animal preclinical hadrontherapy facility

    International Nuclear Information System (INIS)

    Russo, G.; Pisciotta, P.; Cirrone, G.A.P.; Romano, F.; Cammarata, F.; Marchese, V.; Forte, G.I.; Lamia, D.; Minafra, L.; Bravatá, V.; Acquaviva, R.; Gilardi, M.C.; Cuttone, G.

    2017-01-01

    Aim of this work is the study of the preliminary steps to perform a particle treatment of cancer cells inoculated in small animals and to realize a preclinical hadrontherapy facility. A well-defined dosimetric protocol was developed to explicate the steps needed in order to perform a precise proton irradiation in small animals and achieve a highly conformal dose into the target. A precise homemade positioning and holding system for small animals was designed and developed at INFN-LNS in Catania (Italy), where an accurate Monte Carlo simulation was developed, using Geant4 code to simulate the treatment in order to choose the best animal position and perform accurately all the necessary dosimetric evaluations. The Geant4 application can also be used to realize dosimetric studies and its peculiarity consists in the possibility to introduce the real target composition in the simulation using the DICOM micro-CT image. This application was fully validated comparing the results with the experimental measurements. The latter ones were performed at the CATANA (Centro di AdroTerapia e Applicazioni Nucleari Avanzate) facility at INFN-LNS by irradiating both PMMA and water solid phantom. Dosimetric measurements were performed using previously calibrated EBT3 Gafchromic films as a detector and the results were compared with the Geant4 simulation ones. In particular, two different types of dosimetric studies were performed: the first one involved irradiation of a phantom made up of water solid slabs where a layer of EBT3 was alternated with two different slabs in a sandwich configuration, in order to validate the dosimetric distribution. The second one involved irradiation of a PMMA phantom made up of a half hemisphere and some PMMA slabs in order to simulate a subcutaneous tumour configuration, normally used in preclinical studies. In order to evaluate the accordance between experimental and simulation results, two different statistical tests were made: Kolmogorov test and

  6. A preliminary study on titanium-clay interactions

    International Nuclear Information System (INIS)

    Wersin, P.; Grolimund, D.; Kumpulainen, S.; Brendle, J.; Snellman, M.

    2010-01-01

    bentonite, Opalinus Clay, Illite du Puy) were characterized by XAS. Preliminary results can be summarized as: (1) Natural clay materials contain significant but variable amounts of Ti. The standard purification procedure for bentonites to remove accessories does not or only barely removes Ti. (2) The Ti in the natural clays materials Rokle bentonite, Opalinus Clay, Illite du Puy occurs as microcrystalline TiO 2 (presumably as anatase). On the other hand, the Ti spectra in MX-80 suggest the presence of structural Ti in the smectite, but the evidence is not conclusive so far. (3) The exposure of purified MX-80 to titanium powder at room temperature within a period of five months did not lead to measurable additional Ti in the clay. This was even true for samples exposed to acidic or alkaline conditions where corrosion rates and solubility of Ti are known to be higher. Thereof, the following preliminary conclusions can be drawn: - The Ti content in natural bentonites is concentrated mainly in the so-called clay fraction. Ti occurs therein either as separate small TiO 2 particles (Rokle, Opalinus Clay, Illite du Puy) or as structural Ti. As indicated by the study of Karnland et al. (2006), the properties of natural bentonites are not affected by the presence of Ti. In that study, the bulk properties (swelling pressure, hydraulic conductivity) were very similar for the different bentonites containing variable Ti content, ranging from 0.1 to 4.8 weight % TiO 2 in the purified clay fractions. The transfer rates of Ti from the metallic source, even in reactive powder form, to the clay are very low and no enrichment above background concentrations after several months could be observed. In order to obtain measurable effects, both the corrosion process must be increased and the background concentration must be reduced. Tests with Ti-free clay material at increased temperature are still ongoing and will hopefully enable identification of reacted Ti species. (authors)

  7. Preliminary study on domestication of coconut crab (Birgus latro

    Directory of Open Access Journals (Sweden)

    . Sulistiono

    2007-07-01

    Full Text Available Preliminary study on domestication of coconut crab (Birgus latro had been done since June - November 2004 and December - 2005 February 2006.  Study was carried out in two locations namely Laboratory of Sekolah Tinggi Kelautan dan Perikanan, Palu to study adult crab, and Laboratory of Ecobiology of Faculty of Fisheries and Marine Science, Bogor Agricultural University to study crab in clomang stage.  Adult crabs were collected by using some fishing gears namely trap, net and directly using bamboo stick.  Domestication was done in rearing batch sized 1x1x1 m3 with artificial nests (30x15x15 cm3, and small batch for water (7x10x10 cm3.  While for clomang stage, crabs were reared in aquarium (80x40x40 cm3 with debris and small water batch.  Result showed that adult crab had a survival rate around 12.5-0%, and mortality around 50-87.5%.  A similar result was also in clomang stage, which was 12.5% for survival rate and 87.5% for mortality.  Adult coconut crab was preferred to feed coconut than other food likely vegetable and chick. Keywords: domestication, coconut crab, Birgus latro, food habit   ABSTRAK Penelitian awal mengenai kajian awal penangkaran kepiting kelapa (Birgus latro dilakukan pada bulan Juni - November 2004 dan Desember 2005 Februari 2006.  Pelaksanaan penelitian di lakukan di dua tempat, yaitu Laboratorium Sekolah Tinggi Kelautan dan Perikanan, Palu untuk percobaan kepiting dewasa, dan Laboratorium Ekobiologi Fakultas Perikanan dan Ilmu Kelautan IPB Bogor,  untuk percobaan kepiting tahap klomang.  Kepiting dewasa ditangkap dengan menggunakan beberapa peralatan a.l. perangkap, jaring dan secara langsung dengan tongkat.  Penangkaran dilakukan di bak-bak peliharaan berukuran 1x1x1 m3 yang dilengkapi dengan tempat persembunyian (30x15x15 cm3, dan bak kecil tempat air (7x10x10 cm3.  Sedangkan kepiting tahap klomang dipelihara di akuarium (80x40x40 cm3 yang diberi daun/serasah dan tempat air.  Hasil uji coba penangkaran

  8. Preliminary design studies for the DESCARTES and CIDER codes

    International Nuclear Information System (INIS)

    Eslinger, P.W.; Miley, T.B.; Ouderkirk, S.J.; Nichols, W.E.

    1992-12-01

    The Hanford Environmental Dose Reconstruction (HEDR) project is developing several computer codes to model the release and transport of radionuclides into the environment. This preliminary design addresses two of these codes: Dynamic Estimates of Concentrations and Radionuclides in Terrestrial Environments (DESCARTES) and Calculation of Individual Doses from Environmental Radionuclides (CIDER). The DESCARTES code will be used to estimate the concentration of radionuclides in environmental pathways, given the output of the air transport code HATCHET. The CIDER code will use information provided by DESCARTES to estimate the dose received by an individual. This document reports on preliminary design work performed by the code development team to determine if the requirements could be met for Descartes and CIDER. The document contains three major sections: (i) a data flow diagram and discussion for DESCARTES, (ii) a data flow diagram and discussion for CIDER, and (iii) a series of brief statements regarding the design approach required to address each code requirement

  9. Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.

    Science.gov (United States)

    Weintraub, Daniel; Koester, Juergen; Potenza, Marc N; Siderowf, Andrew D; Stacy, Mark; Voon, Valerie; Whetteckey, Jacqueline; Wunderlich, Glen R; Lang, Anthony E

    2010-05-01

    An association between dopamine-replacement therapies and impulse control disorders (ICDs) in Parkinson disease (PD) has been suggested in preliminary studies. To ascertain point prevalence estimates of 4 ICDs in PD and examine their associations with dopamine-replacement therapies and other clinical characteristics. Cross-sectional study using an a priori established sampling procedure for subject recruitment and raters blinded to PD medication status. Three thousand ninety patients with treated idiopathic PD receiving routine clinical care at 46 movement disorder centers in the United States and Canada. The Massachusetts Gambling Screen score for current problem/pathological gambling, the Minnesota Impulsive Disorders Interview score for compulsive sexual behavior and buying, and Diagnostic and Statistical Manual of Mental Disorders research criteria for binge-eating disorder. An ICD was identified in 13.6% of patients (gambling in 5.0%, compulsive sexual behavior in 3.5%, compulsive buying in 5.7%, and binge-eating disorder in 4.3%), and 3.9% had 2 or more ICDs. Impulse control disorders were more common in patients treated with a dopamine agonist than in patients not taking a dopamine agonist (17.1% vs 6.9%; odds ratio [OR], 2.72; 95% confidence interval [CI], 2.08-3.54; P disorder frequency was similar for pramipexole and ropinirole (17.7% vs 15.5%; OR, 1.22; 95% CI, 0.94-1.57; P = .14). Additional variables independently associated with ICDs were levodopa use, living in the United States, younger age, being unmarried, current cigarette smoking, and a family history of gambling problems. Dopamine agonist treatment in PD is associated with 2- to 3.5-fold increased odds of having an ICD. This association represents a drug class relationship across ICDs. The association of other demographic and clinical variables with ICDs suggests a complex relationship that requires additional investigation to optimize prevention and treatment strategies. clinicaltrials

  10. Frontal lobe proton magnetic-resonance spectroscopy in Graves' disease: a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Khushu, S.; Gupta, A.; Sankar, R.; Tripathi, R.P.; Bhatara, V.S. [NMR Research Center and Department of Endocrinology, Institute of Nuclear Medicine and Allied Sciences, Lucknow Marg, Delhi 110054 (India)

    1998-08-01

    Patients with hyperthyroidism may show impaired performance on several neuropsychological tests that require complex visual discrimination, conceptualization, mental flexibility or organization. These neurocognitive impairments appear to be consistent with prefrontal lobe dysfunction. This pilot study was undertaken to characterize the metabolite profile in the right prefrontal cortex in six patients with untreated Graves' disease by using in vivo proton magnetic-resonance spectroscopy ({sup 1}H-MRS). For comparison, {sup 1}H-MRS was also carried out inseven healthy controls. The choline/creatine (Cho/Cr) and N-acetyl aspartate/creatine (Naa/Cr) ratios were determined. Cho/Cr ratios of the hyperthyroid patients were significantly lower than that of controls (means{+-}SD=0.61{+-}0.09 vs. 0.90{+-}0.18, p=.05). The two groups did not differ in their Naa/Cr ratios. Follow-up data after antithyroid treatment were available in three patients: Cho/Cr ratios were higher after treatment (euthyroidism) than before treatment (1.06 vs. 0.55; 0.82 vs. 0.54; 1.15 vs. 0.76). Tentatively, these preliminary data are most consistent with reversible reductions in the concentrations of choline-containing compounds (especially glycerophosphocholine and phosphocholine) in the prefrontal area during hyperthyroidism. However, these findings await confirmation by a definitive study with a larger sample size. A possible explanation of the findings is an altered brain cholinergic-adrenergic balance in hyperthyroidism. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  11. Towards collaboration between professional caregivers and robots - A preliminary study

    OpenAIRE

    Malaisé , Adrien; Nertomb , Sophie; Charpillet , François; Ivaldi , Serena

    2016-01-01

    International audience; In this paper, we address the question of which potential use of a robot in a health-care environment is imagined by people that are not experts in robotics, and how these people imagine to teach new movements to a robot. We report on the preliminary results of our investigation , in which we conducted 40 interviews with non-experts in robotics and a focus group with professional caregivers.

  12. PRELIMINARY STUDY OF FISH CULTURE IN ABANDONED SAND MINING POOL

    Directory of Open Access Journals (Sweden)

    Bambang Gunadi

    2006-12-01

    Full Text Available One of main problems in freshwater aquaculture development in Indonesia, especially in Java, is unavailability of developing zone. It is important to find an underutilized area that meets for industrial scale freshwater aquaculture, i.e. sufficient water supply, wide area, and located in one area or zone. The abandoned mining (sand, tin, etc. pools distributed along the country might be the potential area for freshwater aquaculture business. For example, there are at least 13 water pools with total surface area of 250 ha at 15 km side of Citarum River in Karawang District (West Java Province. This study was conducted to obtain preliminary data about the prospect and potency of fish culture (tilapia, clariid catfish, and ‘patin’ catfish in abandoned sand-mining pools in Karawang District. Mini floating net cages of 1 x 1 x 1.5 m3 size were used for culturing fish, i.e. patin catfish (Pangasianodon hypophthalmus, nile tilapia (Oreochromis niloticus, and clariid catfish (Clarias gariepinus, separately. Patin catfish were stocked at a size of 2 g with a density of 300 fish per cage, tilapia were stocked at a size of 6 g with a density of 400 fish per cage, while  the clariid catfish were stocked at a size of 1.4 g with a density of 980 fish per cage. A floating commercial feed (30%—32% protein, 3%—5% fat was used at a daily rate of 9% biomass weight at the beginning and reduced gradually to 3% at the final culture period. Observed data showed that patin catfish grew from the initial size of 2.08 g to the final size 299.59 g in 5 months, nile tilapia grew from individual initial size of 5.92 g to the final size of 247.12 g in 14 weeks, and clariid catfish grew from initial size of 1.39 g to the final size of 73.10 g in 8 weeks. These three species were technically prospective for aquaculture development in the abandoned sand-mining pools.

  13. Preliminary study of the nuclear power option in Belarus

    International Nuclear Information System (INIS)

    Grusha, N.M.; Kazazyan, V.T.; Malykhin, A.P.; Mikhalevich, A.A.; Yakushau, A.P.; Yaroshevich, O.I.

    1999-01-01

    The Republic of Belarus possesses an economy with many energy intensive branches. At the same time the share of domestic energy resources is about 15% of total energy demand. The share of the payment for primary energy resources reaches 60% or USD 2 billion of the total energy import. That is comparable with the annual state budget. In addition to that, about half of the installed capacities have reached their operation life and 90% of the units have to be retrofitted or replaced until 2010. Thus, the problem of energy supply is one of the most important ones for Belarus' economy. The nuclear power appears to be one of the possible ways for solving the energy demand problem in Belarus which has, as in case of many countries of Central and South-Eastern Europe, limited energy resources. In 1992 - 1994 the works for studying the possibility of NPP siting were recommenced and six relatively competitive sites have been chosen out from 54 possible locations for NPP siting. Parallely, works on assessment of environmental NPP effect in these sites were carried out. As concerning the reactors to be purchased and installed in the sites selected, the following options were taken into consideration: PWR of American Company WESTINGHOUSE; PWR N4 of France Company FRAMATOME; PWR KONVOI of German Company SIEMENS. Also promising are the new generation of Russian Reactor NPP, namely NPP - 91, NPP - 92 and NPP with NGWWER - 640 reactors. Preliminary assessment having in view the feasibility characteristics, safety, reliability as well as the degree of completion shows the Russian projects NPP - 92 and NGWWER - 640 as more preferably at present. Concerning the radioactive waste management, sites for storing low and medium active waste have been determined as well as regions for high active waste disposal. At present Belarus Republic disposes of a definite production, engineering and scientific potential, which can be used when the nuclear power program will be launched. Construction

  14. Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis.

    Science.gov (United States)

    Rafiei, Mohammad; Kiani, Faezeh; Sayehmiri, Fatemeh; Sayehmiri, Kourosh; Sheikhi, Abdolkarim; Zamanian Azodi, Mona

    2017-01-01

    Background : The mouth cavity hosts various types of anaerobic bacteria including Porphyromonas gingivalis , which causes periodontal inflammatory diseases. P. gingivalis is a gram-negative oral anaerobe and is considered as a main etiological factor in periodontal diseases. Several studies have reported a relationship between P. gingivalis in individuals with periodontal diseases and a critical role of this bacterium in the pathogenesis of periodontal diseases. The present study aimed at estimating this probability using a meta-analysis. Methods : We searched several databases including PubMed, Scopus, Google Scholar, and Web of Science to identify case-control studies addressing the relationship between P. gingivalis with periodontal diseases. A total of 49 reports published from different countries from 1993 to 2014 were included in this study. I² (heterogeneity index) statistics were calculated to examine heterogeneity. Data were analyzed using STATA Version 11. Results : After a detailed analysis of the selected articles, 49 case-control studies with 5924 individuals fulfilled the inclusion criteria for the meta-analysis. The healthy controls included 2600 healthy individuals with a Mean±SD age of 36.56±7.45 years. The periodontal diseases group included 3356 patients with a mean age of 43.62±8.35 years. There was a statistically significant difference between P. gingivalis in periodontal patients and healthy controls; 9.24 (95% CI: 5.78 to 14.77; P = 0.000). In the other word, there was a significant relationship between the presence of P. gingivalis and periodontal diseases. Conclusion : Analyzing the results of the present study, we found a strong association between the presence of P. gingivalis and periodontal diseases. This result suggests that another research is needed to further assess this subject.

  15. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study.

    Science.gov (United States)

    Martínez-Fernández, Raul; Rodríguez-Rojas, Rafael; Del Álamo, Marta; Hernández-Fernández, Frida; Pineda-Pardo, Jose A; Dileone, Michele; Alonso-Frech, Fernando; Foffani, Guglielmo; Obeso, Ignacio; Gasca-Salas, Carmen; de Luis-Pastor, Esther; Vela, Lydia; Obeso, José A

    2018-01-01

    Ablative neurosurgery has been used to treat Parkinson's disease for many decades. MRI-guided focused ultrasound allows focal lesions to be made in deep brain structures without skull incision. We investigated the safety and preliminary efficacy of unilateral subthalamotomy by focused ultrasound in Parkinson's disease. This prospective, open-label pilot study was done at CINAC (Centro Integral de Neurociencias), University Hospital HM Puerta del Sur in Madrid, Spain. Eligible participants had Parkinson's disease with markedly asymmetric parkinsonism. Patients with severe dyskinesia, history of stereotactic surgery or brain haemorrhage, a diagnosis of an unstable cardiac or psychiatric disease, or a skull density ratio of 0·3 or less were excluded. Enrolled patients underwent focused ultrasound unilateral subthalamotomy. The subthalamic nucleus was targeted by means of brain images acquired with a 3-Tesla MRI apparatus. Several sonications above the definitive ablation temperature of 55°C were delivered and adjusted according to clinical response. The primary outcomes were safety and a change in the motor status of the treated hemibody as assessed with part III of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) in both off-medication and on-medication states at 6 months. Adverse events were monitored up to 48 h after treatment and at scheduled clinic visits at 1, 3, and 6 months after treatment. The study is registered with ClinicalTrials.gov, number NCT02912871. Between April 26 and June 14, 2016, ten patients with markedly asymmetric parkinsonism that was poorly controlled pharmacologically were enrolled for focused ultrasound unilateral subthalamotomy. By 6 months follow-up, 38 incidents of adverse events had been recorded, none of which were serious or severe. Seven adverse events were present at 6 months. Three of these adverse events were directly related to subthalamotomy: off-medication dyskinesia in the treated arm

  16. A preliminary study in zero anaphora coreference resolution for Polish

    Directory of Open Access Journals (Sweden)

    Adam Jan Kaczmarek

    2017-12-01

    Full Text Available A preliminary study in zero anaphora coreference resolution for Polish Zero anaphora is an element of the coreference resolution task that has not yet been directly addressed in Polish and, in most studies, it has been left as the most challenging aspect for further investigation. This article presents an initial study of this problem. The preparation of a machine learning approach, alongside engineering features based on linguistic study of the KPWr corpus, is discussed. This study utilizes existing tools for Polish coreference resolution as sources of partial coreferential clusters containing pronoun, noun and named entity mentions. They are also used as baseline zero coreference resolution systems for comparison with our system. The evaluation process is focused not only on clustering correctness, without taking into account types of mentions, using standard CoNLL-2012 measures, but also on the informativeness of the resulting relations. According to the annotation approach used for coreference to the KPWr corpus, only named entities are treated as mentions that are informative enough to constitute a link to real world objects. Consequently, we provide an evaluation of informativeness based on found links between zero anaphoras and named entities. For the same reason, we restrict coreference resolution in this study to mention clusters built around named entities.   Wstępne studium rozwiązywania problemu koreferencji anafory zerowej w języku polskim Koreferencja zerowa, w języku polskim, jest jednym z zagadnień rozpoznawania koreferencji. Dotychczas nie była ona bezpośrednim przedmiotem badań, gdyż ze względu na jej złożoność była pomijana i odsuwana na dalsze etapy badań. Artykuł prezentuje wstępne studium problemu, jakim jest rozpoznawanie koreferencji zerowej. Przedstawiamy podejście wykorzystujące techniki uczenia maszynowego oraz proces tworzenia cech w oparciu o analizę lingwistyczną korpusu KPWr. W przedstawionej

  17. The development and implementation of a regional network of physiotherapists for exercise therapy in patients with peripheral arterial disease, a preliminary report

    Directory of Open Access Journals (Sweden)

    Prins MH

    2005-07-01

    Full Text Available Abstract Background Exercise therapy (ET is the main conservative and proven effective treatment of patients with intermittent claudication. Currently, the most frequent exercise prescription is a single 'go home and walk' advise, without supervision or follow-up. There is no evidence to support the efficacy of this advise and compliance is known to be low. Therefore, a systematic approach was used to guarantee quality and standardisation of treatment, optimal guideline adherence and improved of inter-professional communication between vascular surgeons and physiotherapists. In this preliminary report we would like to outline the steps taken for the development and implementation of the Network Exercise Therapy Parkstad Methods In October 2003 all 59 regional physiotherapy practices were invited to attend a symposium regarding ET in a physiotherapeutic setting. Attending physiotherapists interested in providing ET and willing to follow a certified course on ET, were asked to register. Three tastkgroups were formed to accomplish the set targets: Exercise therapy education, Exercise therapy implementation and continuity, and Inter-professional communication in the Parkstad region. Results In total 27 physiotherapists, from 22 different practices followed the educational program and are now trained and accredited to provide ET according to the guideline of the Royal Dutch Society for Physiotherapy. A web-based database wasdesigned to contain information on disease specific items provided by the vascular surgery department, and aspects with respect to ET registered by the physiotherapist. The information is regularly updated and available online. Access tothe database is restricted to vascular surgeons and physiotherapists in the network. The secondary purpose of the database is to register essential benchmark data for future analysis of ET in a physiotherapeutic setting in the Netherlands and to enable physiotherapists continuous feedback on

  18. Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Francisco Salcido-Ochoa

    2017-01-01

    Full Text Available Aim. To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic minimal change disease. Methods. In a cohort of 9 adult patients with primary/idiopathic minimal change recruited consecutively at disease onset, we characterized (1 infiltrating immune cells in the kidneys using immunohistochemistry and (2 circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Results. In the recruited patients with primary/idiopathic minimal change disease, we observed (a a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3+ Treg cells in the renal interstitium; (b an increase in the circulating total CD8+ T cells in peripheral blood; and (c an association of some of these parameters with kidney function and proteinuria. Conclusions. In primary/idiopathic minimal change disease, a relative numerical dominance of effector over regulatory T cells can be observed in kidney tissue and peripheral blood. However, larger confirmatory studies are necessary.

  19. In Vitro Studies and Preliminary Mathematical Model for Jet Fuel and Noise Induced Auditory Impairment

    Science.gov (United States)

    2015-06-01

    of JP-8 and a Fischer- Tropsch synthetic jet fuel following subacute inhalation exposure in rats. Toxicol Sci 116(1): 239-248. Gallinat, J...AFRL-RH-WP-TR-2015-0084 IN VITRO STUDIES AND PRELIMINARY MATHEMATICAL MODEL FOR JET FUEL AND NOISE INDUCED AUDITORY IMPAIRMENT...April 2014 – September 2014 4. TITLE AND SUBTITLE In Vitro Studies and Preliminary Mathematical Model for Jet Fuel and Noise Induced Auditory

  20. A phenomenological study on resilience of the elderly suffering from chronic disease: a qualitative study

    Directory of Open Access Journals (Sweden)

    Hassani P

    2017-02-01

    Full Text Available Parkhide Hassani,1 Fatemeh-Sadat Izadi-Avanji,2 Mahnaz Rakhshan,3 Hamid Alavi Majd4 1Department of Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Nursing, School of Nursing and Midwifery, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran; 4Department of Biostatistics, Facility of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background: Resilience is a key factor in improving health and attenuating problems caused by chronic diseases in the elderly. Having a clear understanding of its meaning in a specific population can be of great help in taking efficient steps toward better health services. Given the lack of information in this regard, the aim of this study was to understand the meaning of resilience for hospitalized older people who experience chronic conditions.Methods: The study was carried out as a qualitative work based on a descriptive phenomenological approach. The participants were selected purposefully, so that 22 elderly with chronic disease were interviewed in 24 sessions. The collected data were recorded and analyzed through Colaizzi’s method.Results: Four themes were extracted from the interviews as follows: 1 “meaning of resilience in the participants’ experiences” with subthemes of “the art of overcoming pain and suffering”, “adapt to health problem of senescence”, “accepting life with the chronic disease”, and “patience and trust in God”; 2 “growth context as a prologue of resilience” with subthemes of “growth background”; 3 “external factors contributing to resilience” with subthemes of “welfare”, “received support”, “deprivation and shortage”, and “attitudes toward an elderly with health problem”; and 4

  1. Polysomnographic Findings and Clinical Correlates in Huntington Disease: A Cross-Sectional Cohort Study

    Science.gov (United States)

    Piano, Carla; Losurdo, Anna; Della Marca, Giacomo; Solito, Marcella; Calandra-Buonaura, Giovanna; Provini, Federica; Bentivoglio, Anna Rita; Cortelli, Pietro

    2015-01-01

    Study Objectives: To evaluate the sleep pattern and the motor activity during sleep in a cohort of patients affected by Huntington disease (HD). Design: Cross-sectional cohort study. Setting: Sleep laboratory. Patients: Thirty HD patients, 16 women and 14 men (mean age 57.3 ± 12.2 y); 30 matched healthy controls (mean age 56.5 ± 11.8 y). Interventions: Subjective sleep evaluation: Epworth Sleepiness Scale (ESS); Berlin's Questionnaire, interview for restless legs syndrome (RLS), questionnaire for REM sleep behavior disorder (RBD). Clinical evaluation: disease duration, clinical severity (unified Huntington disease motor rating scale [UHDMRS]), genetic tests. Laboratory-based full-night attended video-polysomnography (V-PSG). Measurements and Results: The duration of the disease was 9.4 ± 4.4 y, UHMDRS score was 55.5 ± 23.4, CAG repeats were 44.3 ± 4.1. Body mass index was 21.9 ± 4.0 kg/m2. No patients or caregivers reported poor sleep quality. Two patients reported symptoms of RLS. Eight patients had an ESS score ≥ 9. Eight patients had high risk of obstructive sleep apnea. At the RBD questionnaire, two patients had a pathological score. HD patients, compared to controls, showed shorter sleep, reduced sleep efficiency index, and increased arousals and awakenings. Four patients presented with sleep disordered breathing (SDB). Periodic limb movements (PLMs) during wake and sleep were observed in all patients. No episode of RBD was observed in the V-PSG recordings, and no patients showed rapid eye movement (REM) sleep without atonia. The disease duration correlated with ESS score (P Marca G, Solito M, Calandra-Buonaura G, Provini F, Bentivoglio AR, Cortelli P. Polysomnographic findings and clinical correlates in Huntington disease: a cross-sectional cohort study. SLEEP 2015;38(9):1489–1495. PMID:25845698

  2. Oral health and oromotor function in rare diseases--a database study.

    Science.gov (United States)

    Sjögreen, Lotta; Andersson-Norinder, Jan; Bratel, John

    2015-01-01

    The aim was to study oral health and oromotor function in individuals with rare diseases. A disease is defined as rare when it affects no more than 100 individuals per million population and leads to a marked degree of disability. An affected nervous or musculoskeletal system, cognitive impairment, neuropsychiatric disorders and craniofacial malformations are common in rare diseases and may all be risk factors for oral health and oromotor function. In 1996-2008, 1,703 individuals with 169 rare diseases, aged 3-67 years, answered a questionnaire about general health, oral health and orofacial function and 1,614 participated in a clinical examination. A control group of 135 healthy children, aged 3-14 years, was also included in the study. Oral health was examined by a dentist and oromotor function by a speech-language pathologist. The participants with rare diseases were recruited via family programmes, referrals to the clinic and research projects, while the controls were randomly selected from a Swedish municipality. In the diagnosis group, 40% had moderate or severe problems coping with dental treatment, 43% were receiving specialised dental care. Difficulties related to tooth brushing were common compared with the controls. Approximately two thirds of the study group and the control group were caries free. Frontal open bite, long face and high palate were common in individuals with rare diseases compared with controls. Oromotor impairment was a frequent finding (43%) and was absent among the controls. There was a significant correlation between oromotor impairment and certain structural deviations and oral-health issues. Compared with healthy controls, individuals with rare diseases often have difficulty coping with dental treatment and managing tooth brushing. Dysmorphology and oromotor dysfunction are frequent findings in this population and they often require extra prophylactic dental care and access to specialised dental care in order to prevent oral disease.

  3. Traffics and wildlife: A preliminary study on road-kill

    OpenAIRE

    Rustiati, Elly Lestari

    2012-01-01

    This paper presents the preliminary finding on road kill survey by direct observations onthe high ways. The road-kills recorded of small wildlife, including medium size-mammal (2.50%, n =1), birds (5.00%, n = 2) and small mammals (92.50%, n = 37). The small mammals include the mostcommon mammals in the areas, squirrels, raccoons, skunks and woodchuck. Of mammals, squirrels(35.00%) were the highest recorded, followed by woodchucks (25.00%), mice/shrew (17.50%),raccoons (10.00%), skunk (5.00%) ...

  4. Preliminary study of a flux converter for experimental reactor

    International Nuclear Information System (INIS)

    Malouch, M.F.

    1998-01-01

    The purpose of this project is to define the characteristics of a flux converter dedicated to increase the fast neutron flux in irradiation devices placed in the core of Osiris experimental reactor. This preliminary work has dealt with the neutronic and thermal-hydraulic aspects of this problem. The synthesis of the results produced by the codes APOLLO2, DAIXY, MERCURE5.3 and FLICA-3M shows that a cylindrical converter equipped with 5 fissile rings can enhance the fast flux by a 35% factor in an experimental device set in its center. (A.C.)

  5. Preliminary feasibility study of the heat - pipe ENHS reactor

    International Nuclear Information System (INIS)

    Fratoni, M.; Kim, L.; Mattafirri, S.; Petroski, R.; Greenspan, E.

    2007-01-01

    This preliminary study assesses the feasibility of designing an Encapsulated Nuclear Heat Source (ENHS) reactor [1] to have a solid core from which heat is removed by liquid-metal heat pipes (HP). Like the SAFE space nuclear reactor core [2], the HP-ENHS core is comprised of fuel rods and HPs embedded in a solid structure arranged in a hexagonal lattice in a 3:1 ratio. The HPs extend beyond the core length and transfer heat to a secondary coolant that flows by natural circulation. The HP-ENHS reactor is designed to preserve many features of the ENHS reactor including 20-year operation without refueling, very small excess reactivity throughout life, natural circulation cooling, walk-away passive safety, and robust proliferation resistance. The target power level and specific power of the HP-ENHS reactor are those of the reference ENHS reactor [1]. Compared to previous ENHS reactor designs utilizing a lead or lead-bismuth alloy natural circulation cooling system, the HP-ENHS reactor offers a number of possible advantageous features including: (1) significantly enhanced decay heat removal capability; (2) no positive void reactivity coefficients; (3) no direct contact between the fuel clad and coolant, hence, relatively lower wet corrosion of the clad; (4) a core that is more robust for transportation; (5) higher temperature potentially offering higher efficiency and hydrogen production capability. The study focuses on four areas: material compatibility analysis, HP performance analysis, neutronic analysis and thermal-hydraulic analysis. Of four high-temperature structural materials evaluated, Mo TZM alloy is the preferred choice; its upper estimated feasible operating temperature is 1350 K. HP performance is evaluated as a function of working fluid type, operating temperature, wick design and HP diameter and length. Sodium is the preferred working fluid and the HP working temperature is 1300 K. The neutronic analysis found that it is possible to achieve criticality

  6. Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease: A Population-Based Longitudinal Study.

    Science.gov (United States)

    Chang, Jia-Feng; Yeh, Jih-Chen; Chiu, Ya-Lin; Liou, Jian-Chiun; Hsiung, Jing-Ru; Tung, Tao-Hsin

    2017-01-01

    No large epidemiological study has been conducted to investigate the interaction and joint effects of periodontal pocket depth and hyperglycemia on progression of chronic kidney disease in patients with periodontal diseases. Periodontal pocket depth was utilized for the grading severity of periodontal disease in 2831 patients from January 2002 to June 2013. Progression of chronic kidney disease was defined as progression of color intensity in glomerular filtration rate and albuminuria grid of updated Kidney Disease-Improving Global Outcomes guidelines. Multivariable-adjusted hazard ratios (aHR) in various models were presented across different levels of periodontal pocket depth and hemoglobin A1c (HbA1c) in forest plots and 3-dimensional histograms. During 7621 person-years of follow-up, periodontal pocket depth and HbA1C levels were robustly associated with incremental risks for progression of chronic kidney disease (aHR 3.1; 95% confidence interval [CI], 2.0-4.6 for periodontal pocket depth >4.5 mm, and 2.5; 95% CI, 1.1-5.4 for HbA1C >6.5%, respectively). The interaction between periodontal pocket depth and HbA1C on progression of chronic kidney disease was strong (P periodontal pocket depth (>4.5 mm) and higher HbA1C (>6.5%) had the greatest risk (aHR 4.2; 95% CI, 1.7-6.8) compared with the lowest aHR group (periodontal pocket depth ≤3.8 mm and HbA1C ≤6%). Our study identified combined periodontal pocket depth and HbA1C as a valuable predictor of progression of chronic kidney disease in patients with periodontal diseases. While considering the interaction between periodontal diseases and hyperglycemia, periodontal survey and optimizing glycemic control are warranted to minimize the risk of worsening renal function. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Air pollution and emergency department visits for respiratory diseases: A multi-city case crossover study.

    Science.gov (United States)

    Szyszkowicz, Mieczysław; Kousha, Termeh; Castner, Jessica; Dales, Robert

    2018-05-01

    Increasing evidence suggests that ambient air pollution is a major risk factor for both acute and chronic respiratory disease exacerbations and emergencies. The objective of this study was to determine the association between ambient air pollutants and emergency department (ED) visits for respiratory conditions in nine districts across the province of Ontario in Canada. Health, air pollutant (PM 2.5 , NO 2 , O 3 , and SO 2 ), and meteorological data were retrieved from April 2004 to December 2011. Respiratory diseases were categorized as: chronic obstructive pulmonary disease (COPD, including bronchiectasis) and acute upper respiratory diseases. A case-crossover design was used to test the associations between ED visits and ambient air pollutants, stratified by sex and season. For COPD among males, positive results were observed for NO 2 with lags of 3-6 days, for PM 2.5 with lags 1-8, and for SO 2 with lags of 4-8 days. For COPD among females, positive results were observed for O 3 with lags 2-4 days, and for SO 2 among lags of 3-6 days. For upper respiratory disease emergencies among males, positive results were observed for NO 2 (lags 5-8 days), for O 3 , (lags 0-6 days), PM 2.5 (all lags), and SO 2 (lag 8), and among females, positive results were observed for NO 2 for lag 8 days, for O 3 , PM 2.5 among all lags. Our study provides evidence of the associations between short-term exposure to air pollution and increased risk of ED visits for upper and lower respiratory diseases in an environment where air pollutant concentrations are relatively low. Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.

  8. Advance care planning in motor neuron disease: A qualitative study of caregiver perspectives.

    Science.gov (United States)

    Murray, Leigh; Butow, Phyllis N; White, Kate; Kiernan, Matthew C; D'Abrew, Natalie; Herz, Helen

    2016-05-01

    Motor neuron disease is a fatal disease, characterised by progressive loss of motor function, often associated with cognitive deterioration and, in some, the development of frontotemporal dementia. Life-sustaining technologies are available (e.g. non-invasive ventilation and enteral nutrition) but may compromise quality of life for some patients. Timely commencement of 'Advance Care Planning' enables patients to participate in future care choices; however, this approach has rarely been explored in motor neuron disease. We aimed to investigate caregiver perspectives on the acceptability and impact of advance care planning, documented in a letter format, for patients with motor neuron disease and caregivers. This is a qualitative cross-sectional study. Data were analysed by a narrative synthesis approach. Structured interviews were held with 18 former caregivers of deceased patients with motor neuron disease. A total of 10 patients had created a disease-specific advanced directive, 'Letter of Future Care', and 8 had not. A total of four global themes emerged: Readiness for death, Empowerment, Connections and Clarifying decisions and choices. Many felt the letter of future care was or would be beneficial, engendering autonomy and respect for patients, easing difficult decision-making and enhancing communication within families. However, individuals' 'readiness' to accept encroaching death would influence uptake. Appropriate timing to commence advance care planning may depend on case-based clinical and personal characteristics. Advance care planning can assist patients to achieve a sense of control and 'peace of mind' and facilitates important family discussion. However, the timing and style of its introduction needs to be approached sensitively. Tools and strategies for increasing the efficacy of advance care planning for motor neuron disease should be evaluated and implemented. © The Author(s) 2016.

  9. Prevalence of depression and anxiety in patients with chronic digestive system diseases: A multicenter epidemiological study.

    Science.gov (United States)

    Zhang, An-Zhong; Wang, Qing-Cai; Huang, Kun-Ming; Huang, Jia-Guo; Zhou, Chang-Hong; Sun, Fu-Qiang; Wang, Su-Wen; Wu, Feng-Ting

    2016-11-14

    To investigate the prevalence of depression and anxiety in patients with chronic digestive system diseases. A total of 1736 patients with chronic digestive system diseases were included in this cross-sectional study, including 871 outpatients and 865 in-patients. A self-designed General Information for Patients of the Department of Gastroenterology of General Hospitals questionnaire was used to collect each patient's general information, which included demographic data (including age, sex, marital status, and education) and disease characteristics (including major diseases, disease duration, principal symptoms, chronic pain, sleep disorder, and limited daily activities). The overall detection rate was 31.11% (540/1736) for depression symptoms alone, 27.02% (469/1736) for anxiety symptoms alone, 20.68% (359/1736) for both depression and anxiety symptoms, and 37.44% (650/1736) for either depression or anxiety symptoms. Subjects aged 70 years or above had the highest detection rate of depression (44.06%) and anxiety symptoms (33.33%). χ 2 trend test showed: the higher the body mass index (BMI), the lower the detection rate of depression and anxiety symptoms ( χ 2 trend = 13.697, P digestive system tumors had the highest detection rate of depression (57.55%) and anxiety (55.19%), followed by patients with liver cirrhosis (41.35% and 48.08%). Depression and anxiety symptoms were also high in subjects with comorbid hypertension and coronary heart disease. Depression and anxiety occur in patients with tumors, liver cirrhosis, functional dyspepsia, and chronic viral hepatitis. Elderly, divorced/widowed, poor sleep quality, and lower BMI are associated with higher risk of depression and anxiety.

  10. Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study.

    Science.gov (United States)

    Cheng, Yuan-Yang; Kao, Chung-Lan; Lin, Shih-Yi; Chang, Shin-Tsu; Wei, Tz-Shiang; Chang, Shih-Ni; Lin, Ching-Heng

    2018-02-08

    It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases. A retrospective cohort study. Patients registered in Taiwan National Health Insurance Research Database. Patients aged 40-65 years old from 2001 to 2010 were included. Those who received statin treatment before 2001, were diagnosed with spinal degenerative joint diseases or received any spinal surgery before 2004 or had any spinal trauma before 2011 were excluded. A total of 7238 statin users and 164 454 non-users were identified and followed up for the next 7 years to trace the development of spinal degenerative joint disease. The incident rate of spinal degenerative joint diseases and HRs among the groups treated with different statin dosages. A higher dosage of statins was associated with a significantly lower risk of developing spinal degenerative joint disease in patients with hypercholesterolaemia. Compared with the group receiving less than 5400 mg of a statin, the HR of the 11 900-28 000 mg group was 0.83 (95% CI 0.70 to 0.99), and that of the group receiving more than 28 000 mg was 0.81 (95% CI 0.68 to 0.97). Results of subgroup analysis showed a significantly lower risk in men, those aged 50-59 years and those with a monthly income less than US$600. Our study's findings clearly indicated that a higher dosage of statins can reduce the incidence of spinal degenerative joint disease in patients with hypercholesterolaemia, and it can be beneficial for people with a higher risk of spine degeneration. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise

  11. A Preliminary Case Study for Rectenna Sites in Indonesia

    Science.gov (United States)

    Purwanto, Y.; Collins, P.

    2004-12-01

    Electricity power generation using alternative energy sources in Indonesia has become an important policy. Until now, the contribution from alternative energy sources (especially from renewable energy sources) is very small, only about 1% of the total energy supply. It is expected that in the next 10 years this contribution will be raised to 20%. The development of renewable energy sources is primarily performed in remote areas, that are poor in infrastructure facilities. This is considered to be a good policy since there are many such remote areas in Indonesia that need development programs. The existence of Solar Power Satellite system will open a new horizon in alternative energy supply, including Indonesia, because of its higher efficiency compared to conventional terrestrial solar cells, with almost no influence from either climate or solar position. Like other countries in the world, Indonesia, although one of the largest mineral energy producers in the world (i.e. oil, coal, and natural gas), still gives attention to energy diversification programs, including solar energy utilization. SPS, being based on solar energy, could be a good choice. The Indonesian archipelago consists of thousands of islands (more than 13,000) and is the equatorial country with the longest equatorial extent (more than 5000 km). This condition is very good for energy reception from the SPS 2000 pilot plant since the energy transmitting system (spacetenna) will orbit above the equator. Along the equator there could be placed more than four receiving stations (rectenna), especially in remote areas. Thus, it is very important to consider the involvement of Indonesia in SPS energy reception research. This paper describes a preliminary study of the development possibilities in SPS energy reception in Indonesia. To define the rectenna sites and physical development aspect, this study considers some major aspects: environmental, technical, social, and economic aspects. Environmental aspects

  12. Cadmium Telluride and Grain Boundaries: A Preliminary Study

    Science.gov (United States)

    Liao, Michael Evan

    The efficacy of the CdCl2 treatment on polycrystalline CdTe-based solar cells was discovered over a quarter of a century ago; and yet, the exact mechanism of this treatment is still not fully understood to this day. In fact, the lack of understanding stems from a debate on the exact role of grain boundaries in CdCl2-treated CdTe solar cells. Some hypothesize that the CdCl2-treatment causes grain boundaries to become beneficial to solar cell performance while others disagree and claim that the treatment simply mitigates the harmful effects of grain boundaries via passivation. A future goal of this project is to determine which, if either, hypothesis is correct by direct wafer bonding single crystalline CdTe. Direct wafer bonding of single crystalline materials would create only one grain boundary at the bonded interface. This approach allows the orientation and surface chemistry of interfaces to be controlled in order to study the chemistry of grain boundaries methodically. However, before any direct wafer bonding can be done, a preliminary study of single crystalline CdTe is necessary. High-quality direct wafer bonding can only be achieved if the surfaces of each wafer satisfy certain requirements. Additionally, analyzing single crystalline CdTe materials prior to bonding is crucial in order to make any insightful connections between results found from direct bonding of single crystalline CdTe and what is observed in polycrystalline CdTe. First, the surface of an (001) CdTe layer epitaxially grown on an (001) InSb substrate is studied using atomic force microscopy. Stacking faults on the CdTe surface are observed and the thickness of the grown CdTe epilayer is calculated by considering the interplanar angles between the (001) and (111) crystallographic planes as well as the dimensions of the stacking faults. While the stacking faults will inhibit successful wafer bonding, the roughness of the regions outside the stacking faults is 0.9 nm, which is an acceptable

  13. Preliminary study of varietal susceptibility to sulfur dioxide

    International Nuclear Information System (INIS)

    Miller, J.E.; Xerikos, P.B.

    1976-01-01

    The injury response of plants to air pollutants, such as sulfur dioxide, is known to vary in severity and type for different varieties or cultivars of a species. Differences in the susceptibility of soybean varieties to sulfur dioxide have previously been noted, but sufficient information is not available concerning the sulfur dioxide resistance of varieties commonly grown in the Midwest. Results are reported from preliminary experiments concerning acute sulfur dioxide effects on 12 soybean varieties. The injury symptoms ranged from cream colored necrotic lesions (generally on younger leaves) to a reddish brown necrotic stipling (on older leaves). Differences in the severity of symptom development for the varieties was evident on both the younger and older leaves. No injury was apparent with three of the varieties

  14. Preliminary experimental study of liquid lithium water interaction

    International Nuclear Information System (INIS)

    You, X.M.; Tong, L.L.; Cao, X.W.

    2015-01-01

    Highlights: • Explosive reaction occurs when lithium temperature is over 300 °C. • The violence of liquid lithium water interaction increases with the initial temperature of liquid lithium. • The interaction is suppressed when the initial water temperature is above 70 °C. • Steam explosion is not ignorable in the risk assessment of liquid lithium water interaction. • Explosion strength of liquid lithium water interaction is evaluated by explosive yield. - Abstract: Liquid lithium is the best candidate for a material with low Z and low activation, and is one of the important choices for plasma facing materials in magnetic fusion devices. However, liquid lithium reacts violently with water under the conditions of loss of coolant accidents. The release of large heats and hydrogen could result in the dramatic increase of temperature and pressure. The lithium–water explosion has large effect on the safety of fusion devices, which is an important content for the safety assessment of fusion devices. As a preliminary investigation of liquid lithium water interaction, the test facility has been built and experiments have been conducted under different conditions. The initial temperature of lithium droplet ranged from 200 °C to 600 °C and water temperature was varied between 20 °C and 90 °C. Lithium droplets were released into the test section with excess water. The shape of lithium droplet and steam generated around the lithium were observed by the high speed camera. At the same time, the pressure and temperature in the test section were recorded during the violent interactions. The preliminary experimental results indicate that the initial temperature of lithium and water has an effect on the violence of liquid lithium water interaction.

  15. Preliminary experimental study of liquid lithium water interaction

    Energy Technology Data Exchange (ETDEWEB)

    You, X.M.; Tong, L.L.; Cao, X.W., E-mail: caoxuewu@sjtu.edu.cn

    2015-10-15

    Highlights: • Explosive reaction occurs when lithium temperature is over 300 °C. • The violence of liquid lithium water interaction increases with the initial temperature of liquid lithium. • The interaction is suppressed when the initial water temperature is above 70 °C. • Steam explosion is not ignorable in the risk assessment of liquid lithium water interaction. • Explosion strength of liquid lithium water interaction is evaluated by explosive yield. - Abstract: Liquid lithium is the best candidate for a material with low Z and low activation, and is one of the important choices for plasma facing materials in magnetic fusion devices. However, liquid lithium reacts violently with water under the conditions of loss of coolant accidents. The release of large heats and hydrogen could result in the dramatic increase of temperature and pressure. The lithium–water explosion has large effect on the safety of fusion devices, which is an important content for the safety assessment of fusion devices. As a preliminary investigation of liquid lithium water interaction, the test facility has been built and experiments have been conducted under different conditions. The initial temperature of lithium droplet ranged from 200 °C to 600 °C and water temperature was varied between 20 °C and 90 °C. Lithium droplets were released into the test section with excess water. The shape of lithium droplet and steam generated around the lithium were observed by the high speed camera. At the same time, the pressure and temperature in the test section were recorded during the violent interactions. The preliminary experimental results indicate that the initial temperature of lithium and water has an effect on the violence of liquid lithium water interaction.

  16. How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan

    OpenAIRE

    Santus Pierachille; Russo Antonio; Madonini Enzo; Allegra Luigi; Blasi Francesco; Centanni Stefano; Miadonna Antonio; Schiraldi Gianfranco; Amaducci Sandro

    2012-01-01

    Abstract Background Environmental pollution is a known risk factor for multiple diseases and furthermore increases rate of hospitalisations. We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy. Methods We collected data from 45770 ERAs for respiratory diseases. A time-stratified case-crossover design was used to investigate the association bet...

  17. Efficacy between high and medium doses of glucocorticoid therapy in remission induction of IgG4-related diseases: a preliminary randomized controlled trial.

    Science.gov (United States)

    Wu, Qingjun; Chang, Jie; Chen, Hua; Chen, Yu; Yang, Hongxian; Fei, Yunyun; Zhang, Panpan; Zeng, Xiaofeng; Zhang, Fengchun; Zhang, Wen

    2017-05-01

    In order to evaluate the efficacy and safety of high versus medium doses of glucocorticoid therapy in remission induction of immunoglobulin G4-related disease (IgG4-RD), we set up a randomized controlled study. Newly diagnosed IgG4-RD patients were randomly assigned to two groups: high doses of prednisone (0.8-1.0 mg/kg/day) and medium doses (0.5-0.6 mg/kg/day). Patients were assessed at weeks 0, 4, 12 and 24. The primary outcome was the remission rate at week 24. The secondary endpoints included IgG4-RD responder index (IgG4-RD RI), IgG and IgG4 levels. Twenty cases in each group finished the study. At week 24, the total response rates were 95% and 80% in high and medium dose groups, respectively. There was no significant difference between the two groups. IgG4-RD RI reduced from 14.9 to 3.0 in the high dose group, while in the medium dose group it was from 13.1 to 3.2. At week 24, the average level of IgG4 reduced from 1576 to 324 mg/dL and from 1445 to 684 mg/dL in the two groups, respectively. Relapsed patients had higher baseline IgG4-RD RI. There was no severe adverse effect shown in both groups. The effect of remission induction was similar in high and medium glucocorticoid groups. However, patients with more organs involved and higher IgG4-RD RI score at baseline might get more benefit with high dose glucocorticoid for remission induction. © 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

  18. Preliminary studies of monoclonal antibody lymphoscintigraphy in malignant melanoma

    International Nuclear Information System (INIS)

    Nelp, W.B.; Eary, J.F.; Jones, R.F.; Hellstrom, K.E.; Hellstrom, I.; Beaumier, P.L.; Krohn, K.A.

    1987-01-01

    Lymphoscintigraphy was performed at 3 and 20 hr following subcutaneous injection of 131 I anti-melanoma antibody (Fab) in 11 patients who had surgical resection of lymph nodes (neck, axilla, groin) at 24 hr for suspected metastatic melanoma. Comparable amounts of 125 I nonspecific control antibody (Fab) were co-administered. Six patients had nodal metastases and three showed positive images at both time periods. Five patients had no metastases though one was image positive. Four other nondiseased inguinal node groups were image negative. A total of 28 tumored nodes and 110 normal nodes were removed, counted and histologically examined. All metastatic tumors expressed antigen against which the specific Fab was directed. The concentrations of both specific and nonspecific Fab were similar in tumored nodes and both were significantly greater than in normal nodes showed essentially identical intranodal spatial distribution of the specific and control Fab in areas containing tumor. These preliminary results suggest the increased concentration of murine immunoglobulin (Fab) retained in diseased nodes was a nonspecific phenomenon

  19. Preliminary studies on a plasma focus opening switch

    Energy Technology Data Exchange (ETDEWEB)

    Wong, C S; Moo, S P; Singh, J P [Univ. of Malaya, Kuala Lumpur (Malaysia). Physics Dept., Plasma Research Laboratory; Choi, P [Ecole Polytechnique, Palaiseau (France). Laboratoire de Physique des Milieux Ionises

    1997-12-31

    The small plasma focus device UNU/ICTP PFF has been modified to assess the operation of a plasma focus based long conduction (> 2 {mu}s) opening switch, with a plasma filled diode as the load. The UNU/ICTP PFF is a Mather type plasma focus device powered by a single 15 kV, 30 {mu}F capacitor delivering a peak current of 150 kA when discharged at 15 kV. The device has been optimized for reproducible focusing in various gases including deuterium, argon, carbon dioxide, helium as well as in air. In particular, the optimum operating pressure for air is between 0.5 to 1.1 mbar, whereas for argon it is between 0.3 to 3 mbar. For the operation of the UNU/ICTP PFF as an opening switch, the electrode geometry is modified to redirect the plasma motion at the end of the axial rundown phase to avoid the normal plasma focus action, and the operating regime is shifted to low pressure to favour plasma opening switch action. With air as the working gas, pressure as low as 10{sup -3} mbar was tested. At such a low pressure, a set of 12 plasma injection cable guns is used to initiate breakdown of the discharge. The design and operating principle is presented and some preliminary results obtained on the operational characteristics of this device are discussed. (author). 5 figs., 4 refs.

  20. Preliminary Clinical Study On Ms Treatment With Hyperbaric Oxygenation

    Directory of Open Access Journals (Sweden)

    Ulewicz Kazimierz

    2015-06-01

    Full Text Available The authors conducted the preliminary clinical investigation on 16 multiple sclerosis (Sclerosis multiplex patients of median disease duration 9.33 years and symptoms evaluated on Kurtzke’s scale. The patients underwent between 25 and 30 hyperbaric oxygen exposures at a pressure of 2 ata in intervals spread over a few days. The patients were qualified and classified to the treatment symptomatologically according to Fisher but the obtained results were evaluated according to the standardised Disability Status Scale by Kurtzke. During the investigations the authors carried out additional quantitative immunoglobulin and complement activity determination, lymphocyte T and B determinations as well as the usually applied clinical and laboratory investigations. Evident clinical improvement was observed in 14 patients, but in the case of one patient a deterioration was observed after 15 hyperbaric expositions (resulting in the hyperbaric oxygen treatment being stopped, whilst in another case no curative effect could be observed. By utilising the 50% haemolysis method, within the examined immunological parameters the authors observed an increase of complement fractions and its activity, white lymphocytes T and B examined qualitatively did not maintain the characteristic shift. The authors are still discussing the obtained results.

  1. Preliminary studies of the plasma focus as an opening switch

    International Nuclear Information System (INIS)

    Venneri, F.; Gerdin, G.

    1983-01-01

    Sharp current interruption at pinch time suggests the possible application of the plasma focus as an opening switch. Switch impedances on the order of 0.5 ohms or greater would be of interest to pulsed power applications if the rise time for the impedance is sufficiently short. The experimental determination of the magnitude of the plasma focus impedance at pinch time and its nature (R or L) are obviously important in assessing the feasibility of this application. An experimental estimate of the Spitzer resistance of the plasma focus based on soft-X-ray measurements indicates a Spitzer resistance of 9 mΩ. Estimates of resistance based on the maximum particle energy observed 4 (V about E /sub MAX/ /e) and the current at pinch time (R about E /sub MAX/ /eI /sub p/ ) would indicate an effective resistance of about one ohm. Estimates of resistance based on circuit parameters (L, I, q/C) yield about one third of an ohm. To resolve these discrepancies a exclamationBexclamation probe 5 is being developed to get a better estimate of L(t), L(t) and I(t) through spatially resolved measurements. Preliminary results are reported

  2. The Myres Hill remote sensing intercomparison study: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Clive, P J M; Chindurza, I [SgurrEnergy Ltd, 79 Coplaw Street, Glasgow G42 7JG, Scotland (United Kingdom); Ravey, I; Bass, J [RES Group Ltd, James Blyth House, 7000 Academy Park, Glasgow, Scotland (United Kingdom); Boyle, R J; Jones, P [TUV NEL Ltd, East Kilbride, Glasgow G75 0QF, Scotland (United Kingdom); Lang, S J [Sustainable Energy Research Group, University College Cork (Ireland); Bradley, S [Mighty River Power, Level 14, 23-29 Albert Street, Auckland (New Zealand); Hay, L [Garrad Hassan and Partners Ltd, 2064 Maryhill Road, Glasgow G20 0AB, Scotland (United Kingdom); Oldroyd, A [Oldbaum Services Ltd, Schoolhouse, Brig o' Turk, Callander, Scotland (United Kingdom); Stickland, M [University of Strathclyde, 16 Richmond Street, Glasgow G1 1XQ, Scotland (United Kingdom)], E-mail: peter.clive@sgurrenergy.com

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  3. Cost risk analysis of radioactive waste management Preliminary study

    International Nuclear Information System (INIS)

    Forsstroem, J.

    2006-12-01

    This work begins with exposition of the basics of risk analysis. These basics are then applied to the Finnish radioactive waste disposal environment in which the nuclear power companies are responsible for all costs of radioactive waste management including longterm disposal of spent fuel. Nuclear power companies prepare cost estimates of the waste disposal on a yearly basis to support the decision making on accumulation of resources to the nuclear waste disposal fund. These cost estimates are based on the cost level of the ongoing year. A Monte Carlo simulation model of the costs of the waste disposal system was defined and it was used to produce preliminary results of its cost risk characteristics. Input data was synthesised by modifying the original coefficients of cost uncertainty to define a cost range for each cost item. This is a suitable method for demonstrating results obtainable by the model but it is not accurate enough for supporting decision making. Two key areas of further development were identified: the input data preparation and identifying and handling of (i.e. eliminating or merging) interacting cost elements in the simulation model. Further development in both of the mentioned areas can be carried out by co-operating with the power companies as they are the sources of the original data. (orig.)

  4. CSF Biomarkers and Its Associations with 18F-AV133 Cerebral VMAT2 Binding in Parkinson's Disease-A Preliminary Report.

    Directory of Open Access Journals (Sweden)

    Rui Gao

    Full Text Available Cerebrospinal fluid (CSF biomarkers, such as α-synuclein (α-syn, amyloid beta peptide 1-42 (Aβ1-42, phosphorylated tau (181P (p-tau, and total tau (t-tau, have long been associated with the development of Parkinson disease (PD and other neurodegenerative diseases. In this investigation, we reported the assessment of CSF biomarkers and their correlations with vesicular monoamine transporter 2 (VMAT2 bindings measured with 18F-9-fluoropropyl-(+-dihydrotetrabenazine (18F-AV133 that is being developed as a biomarker for PD. We test the hypothesis that monoaminergic degeneration was correlated with CSF biomarker levels in untreated PD patients.The available online data from the Parkinson's Progression Markers Initiative study (PPMI project were collected and analyzed, which include demographic information, clinical evaluations, CSF biomarkers (α-syn, Aβ1-42, p-tau, and t-tau, 18F-AV133 brain PET, and T1 weighted MRIs. Region of interest (ROI and voxel-wise Pearson correlation between standardized uptake value ratio (SUVR and CSF biomarkers were calculated.Our major findings are: 1 Compared with controls, CSF α-syn and tau levels decreased significantly in PD; 2 α-syn was closely correlated with Aβ1-42 and tau in PD, especially in early-onset patients; and 3 hypothesis-driven ROI analysis found a significant negative correlation between CSF Aβ1-42 levels and VMAT2 densities in post cingulate, left caudate, left anterior putamen, and left ventral striatum in PDs. CSF t-tau and p-tau levels were significantly negatively related to VMAT2 SUVRs in substantia nigra and left ventral striatum, respectively. Voxel-wise analysis showed that left caudate, parahippocampal gyrus, insula and temporal lobe were negatively correlated with Aβ1-42. In addition, superior frontal gyrus and transverse temporal gyrus were negatively correlated with CSF p-tau levels.These results suggest that monoaminergic degeneration in PD is correlated with CSF biomarkers

  5. A preliminary study of variation of Trapa in Japan

    Science.gov (United States)

    Kadono, Yasuro; Rybicki, Nancy B.; Lai, Vincent

    2018-05-31

    SummaryFrequent occurrence of intermediate forms and poor knowledge on the variability of characters have caused some difficulties in the taxonomy of Trapa in Japan. Thus I made a preliminary analysis on the variation of nuts collected from 21 populations in Southwestern Japan. Attention was paid to some morphometrical characters of the nut and development of lower spines or “pseudohorns.” Each population usually contained different forms of nuts. Among them, however, several entities could be recognized based on the shape of nut as follows. 1) Two-spined form: This included nuts of middle size (width 30–50 mm) and ones of big size (width over 45 mm). In case of the former ones, the nuts with pseudohorns of varying degree of development usually occurred together within one population and even on a single plant. I propose to treat them as one taxon, Trapa japonica, sensu OHWI (1965), without inventing varieties. But at the same time, it was remarkable that the tendency of development of pseudohorns was apparently different from population to population. The bigger ones included two types, that is, one without pseudohorns and the other with pseudohorns. The former one may be identified as T. bispinosa ROXB., but the latter one has not been described in literature. 2) Four-spined form: The nuts of small size (width of about 20 mm) were well definable and thought to be T. incisa SIEB. et ZUCC. The nuts of bigger size showed some variations with respect to their size and/or stoutness of lower spines. The big ones (width over 45 mm) may be treated as one taxon, T. natans or its variety. The nuts of middle size have been named T. natans var. pumila NAKANO. But so far as present materials were concerned, its entity seemed dubious. They might be immature nuts of bigger ones. The different patterns of variation among populations were ascribed to genetic differentiation. Predominance of self-pollination and isolation of habitats were thought to promote genetic isolation

  6. Wind farm layout optimization in complex terrain: A preliminary study on a Gaussian hill

    DEFF Research Database (Denmark)

    Feng, Ju; Shen, Wen Zhong

    2014-01-01

    this problem for WFs in flat terrain or offshore has been investigated in many studies, it is still a challenging problem for WFs in complex terrain. In this preliminary study, the wind flow conditions of complex terrain without WTs are first obtained from computational fluid dynamics (CFD) simulation...

  7. Thermal treatment of recycled concrete aggegate for general use in concrete. A preliminary study

    NARCIS (Netherlands)

    Larbi, J.A.; Heijnen, W.M.M.; Brouwer, J.P.; Mulder, E.

    2000-01-01

    In this paper, the results of a preliminary laboratory study to assess the effectiveness of thermally treating recycled concrete aggregate for genera) use in concrete are presented. The samples used for the study consisted of sieved fractions of crushed concrete that were subjected to various

  8. PRELIMINARY EXPOSURE ASSESSMENT FINDINGS FROM THE TAMPA ASTHMATIC CHILDREN'S STUDY

    Science.gov (United States)

    The Tampa Asthmatic Children's Study (TACS) was a pilot study that focused on developing and evaluating air pollution exposure assessment methods and participant recruiting tools. The four-week study was performed in October and November, 2003. The study involved repeated daily...

  9. Zero-gravity cloud physics laboratory: Experiment program definition and preliminary laboratory concept studies

    Science.gov (United States)

    Eaton, L. R.; Greco, E. V.

    1973-01-01

    The experiment program definition and preliminary laboratory concept studies on the zero G cloud physics laboratory are reported. This program involves the definition and development of an atmospheric cloud physics laboratory and the selection and delineations of a set of candidate experiments that must utilize the unique environment of zero gravity or near zero gravity.

  10. Occupational Therapy in the Context of Head Start: A Preliminary Survey Study

    Science.gov (United States)

    Bowyer, Patricia; Moore, Cary C.; Thom, Carly

    2016-01-01

    This preliminary, descriptive study yields information on the utilization of occupational therapy services within Head Start programs. Participants completed an Internet-based survey of 25 questions pertaining to the understanding, scope, and utilization of occupational therapy services. Surveys were completed by 35 respondents nationwide. A total…

  11. Preliminary studies of soil erosion in a valley bottom in Ibadan under ...

    African Journals Online (AJOL)

    Preliminary studies of soil erosion in a valley bottom in Ibadan under some tillage practices. EA Aiyelari, SO Oshunsanya. Abstract. No Abstract. Global Journal of Agricultural Sciences Vol. 7 (1) 2008: pp.221-228. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT ...

  12. Preliminary results of a feasibility study for a hard x-ray Kirkpatrick-Baez telescope

    DEFF Research Database (Denmark)

    Joensen, Karsten D.; Gorenstein, Paul; Wood, James L.

    1994-01-01

    the preliminary results of a feasibility study of a multifocus Kirkpatrick-Baez telescope. We conclude that high quality multilayers can be performed on relevant thin large flat substrate with adequate uniformity, and that existing deposition chambers can produce the multilayers at a rate of 0.42 m2 per day, so...

  13. A Qualitative Study of Factors Influencing Racial Diversity in Environmental Education: Preliminary Results

    Science.gov (United States)

    Kathy James; Leo H. McAvoy

    1992-01-01

    This study presents preliminary result interviews with people of color working in environmental education and interpretation throughout the United States. The three primary questions asked were these? (1) What path led each individual to a career in environmental education; (2) How does each individual define environmentalism? and (3) What are the primary issues this...

  14. The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Breinholst, Sonja; Reinholdt-Dunne, Marie Louise

    2011-01-01

    Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada....

  15. ICT and UD: Preliminary Study for Recommendations to Design Accessible University Courses.

    Science.gov (United States)

    Pagliara, Silvio Marcello; Sánchez Utgé, Marta; De Anna, Lucia

    2017-01-01

    Starting from the Universal Design in the educational context principles, the experiences gained during the FIRB project "Net@ccessibility" and the high-education courses for teachers' specialization on special education, this research will focus on preliminary studies in order to define the recommendations for designing accessible university courses.

  16. Good Feedback for bad Players? A preliminary Study of ‘juicy’ Interface feedback

    DEFF Research Database (Denmark)

    Juul, Jesper; Jason, Begy

    2016-01-01

    The theories of game feel and juiciness claim that players will feel more competent, and that a game will be perceived as being of higher quality, when players are given large amounts of redundant audiovisual feedback in response to their actions. This poster describes a preliminary empirical study...

  17. A preliminary study to find out maximum occlusal bite force in Indian individuals

    DEFF Research Database (Denmark)

    Jain, Veena; Mathur, Vijay Prakash; Pillai, Rajath

    2014-01-01

    PURPOSE: This preliminary hospital based study was designed to measure the mean maximum bite force (MMBF) in healthy Indian individuals. An attempt was made to correlate MMBF with body mass index (BMI) and some of the anthropometric features. METHODOLOGY: A total of 358 healthy subjects in the ag...

  18. LM-OSL from single grains of quartz: A preliminary study

    DEFF Research Database (Denmark)

    Bulur, E.; Duller, G.A.T.; Solongo, S.

    2002-01-01

    the easy-to-bleach component, those with only the hard-to-bleach component, and those exhibiting all components. The results of this preliminary study show that LM-OSL experiments carried out at the single grain level may give important insights into the luminescence properties observed when viewing...

  19. Work Experiences of People with Mental Illness in Malaysia: A Preliminary Qualitative Study

    Science.gov (United States)

    Boo, Su-Lyn; Loong, Jaymee; Ng, Wai-Sheng

    2011-01-01

    This is a preliminary qualitative study, using a basic interpretive approach, to investigate the work experiences of people with mental illness in Malaysia. Six females and four males (aged 30-70) from a residential home for the mentally ill participated in semi-structured interviews. Three inter-relating themes emerged, namely the experience of…

  20. Fire behaviour - A preliminary study. | W.S.W. | African Journal of ...

    African Journals Online (AJOL)

    Fire behaviour - A preliminary study. ... be taken cognisance of in any future research on fire in relation to vegetation. Keywords: behaviour; botany; environmental conditions; fire; fire behaviour; fire ecology; fires; grass; grasses; management; rate of spread; recovery; south africa; vegetation; veld; veld management; yield ...

  1. A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic scoliosis

    NARCIS (Netherlands)

    Cheung, J.; Halbertsma, J.P.; Veldhuizen, A.G.; Sluiter, W.J.; Maurits, N.M.; Cool, J.C.; van Horn, J.R.

    The paraspinal muscles have been implicated as a major causative factor in the progression of idiopathic scoliosis. Therefore, the objectives of this preliminary study were to measure the electromyographic activity (EMG) of the paraspinal muscles to determine its relationship to progression of the

  2. Preliminary studies in rice-fish culture in a rainfed lowland ecology ...

    African Journals Online (AJOL)

    Mixed farms of rice and fish are yet to receive attention in Ghana, despite lowland rice being grown under inundation in most areas nationwide. In a preliminary study, Nile tilapia (Oreochromis niloticus) was successfully cultured in a rainfed lowland rice farm, although no additional care was provided for fishes. The highest ...

  3. Robot assisted navigated drilling for percutaneous pedicle screw placement: A preliminary animal study

    Directory of Open Access Journals (Sweden)

    Hongwei Wang

    2015-01-01

    Conclusions: The preliminary study supports the view that computer assisted pedicle screw fixation using spinal robot is feasible and the robot can decrease the intraoperative fluoroscopy time during the minimally invasive pedicle screw fixation surgery. As spine robotic surgery is still in its infancy, further research in this field is worthwhile especially the accuracy of spine robot system should be improved.

  4. National Plutonium Workers' Study: considerations and preliminary results

    International Nuclear Information System (INIS)

    Acquavella, J.F.; Wilkinson, G.S.

    1983-03-01

    The National Plutonium Workers' Study developed from the clinical follow-up of workers with body burdens in excess of 10 nCi. The importance of plutonium to energy and weapons development and the uncertainty about its biological effects motivated the formation of an epidemiologic study of more than 125,000 workers at six Department of Energy facilities. This report reviews recent results from The National Plutonium Workers' Study, including an analysis of cancer mortality among workers at the Rocky Flats Plant and a study of malignant melanoma among employees at Los Alamos National Laboratory. The problems inherent in large-scale epidemiologic studies, as well as the future directions for the study, are discussed

  5. PRELIMINARY STUDY TO PRIMARY EDUCATION FACILITIES (A Comparison Study between Indonesia and Developed Countries

    Directory of Open Access Journals (Sweden)

    Lucy Yosita

    2006-01-01

    Full Text Available This writing is a preliminary study to condition of primary education facilities in Indonesia, and then comparing these with theories as well as various relevant cases aimed to know the problem more obviously. Basically, there is difference between primary education facilities in Indonesia with those in developed countries. Meanwhile on the other hand, the condition as well as the completion of education facility is actually as the main factor contributes to address the purpose of learning process. If building design, interior and also site plan were dynamic in form, space, colour and tools, those would be probably more stimulate activity and influence into the growth of students. However, lastly, it is still required further analysis, as an example analysis to student's behaviour in spaces of learning environment, more detail and within enough time, not only at indoor but also at outdoor.

  6. Preliminary studies on pathogenic Leptospira spp . In slaughtered ...

    African Journals Online (AJOL)

    This study was undertaken to investigate the occurrence of pathogenic Leptospira spp. and the associated renal morphological changes in pigs slaughtered in slaughter slabs within Abeokuta metropolis, Nigeria. A total of 42 pigs' kidney samples were randomly collected for the study. The samples were examined using ...

  7. Preliminary studies on some aspects of Kikuyu food habits

    NARCIS (Netherlands)

    Hoorweg, J.C.; Niemeijer, R.

    1980-01-01

    Description of a research project. The studies cover general aspects of Kikuyu food habits such as foods presently in use, the classification of foods and food preferences for children. The emphasises is on the methods employed in these studies which can also be used elsewhere to obtain information

  8. PRELIMINARY CLINICAL STUDY OF KALANCHOE SPATHULATA DC. ON INFLAMMATORY WOUND

    Science.gov (United States)

    Yadav, C. L.; Yadav, C. S.

    1985-01-01

    Here, an attempt is made to study the clinical aspect of Kalanchoe spathulata Dc. It has been observed that would heals rapidly leaving no scar. The study clearly validates the ancient concept of Ayurveda, that without taking the help of surgery, there are several medicinal plants which may cure diseases very well. PMID:22557495

  9. How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan.

    Science.gov (United States)

    Santus, Pierachille; Russo, Antonio; Madonini, Enzo; Allegra, Luigi; Blasi, Francesco; Centanni, Stefano; Miadonna, Antonio; Schiraldi, Gianfranco; Amaducci, Sandro

    2012-10-18

    Environmental pollution is a known risk factor for multiple diseases and furthermore increases rate of hospitalisations. We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy. We collected data from 45770 ERAs for respiratory diseases. A time-stratified case-crossover design was used to investigate the association between air pollution levels and ERAs for acute respiratory conditions. The effects of air pollutants were investigated at lag 0 to lag 5, lag 0-2 and lag 3-5 in both single and multi-pollutant models, adjusted for daily weather variables. An increase in ozone (O(3)) levels at lag 3-5 was associated with a 78% increase in the number of ERAs for asthma, especially during the warm season. Exposure to carbon monoxide (CO) proved to be a risk factor for pneumonia at lag 0-2 and in the warm season increased the risk of ERA by 66%. A significant association was found between ERAs for COPD exacerbation and levels of sulphur dioxide (SO(2)), CO, nitrate dioxide (NO(2)), and particulate matter (PM(10) and PM(2.5)). The multipollutant model that includes all pollutants showed a significant association between CO (26%) and ERA for upper respiratory tract diseases at lag 0-2. For chronic obstructive pulmonary disease (COPD) exacerbations, only CO (OR 1.19) showed a significant association. Exposure to environmental pollution, even at typical low levels, can increase the risk of ERA for acute respiratory diseases and exacerbation of obstructive lung diseases in the general population.

  10. Adenosine-deaminase (ADA activity in Psoriasis (A Preliminary Study

    Directory of Open Access Journals (Sweden)

    S D Chaudhry

    1988-01-01

    Full Text Available Study of adenosine-deaminase activity ′in 23 patients hav-mg psoriasis compared with an equal number of healthy controls revealed significantly high ADA-activity in the psotiatic patients.

  11. Radioiodination of melagenine-II with I-125 (preliminary study)

    International Nuclear Information System (INIS)

    Caso, R.; Ruiz, M.

    1996-01-01

    Radioiodination of Melagenine-II with I-125 farmacokinetic studies was made, using Chloramine-T method. Radiochemical purity and stability of the labelled product were determined by radiochromatography. The labelled Melagenine-II showed two radioactive fractions

  12. Preliminary study of the efficacy of the combination of tamsulosin ...

    African Journals Online (AJOL)

    A.S. Abdelaziz

    2016-12-13

    day) and combinations of it with trospium .... Hence, we left with a total of. 126 patients: ..... symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU Int.

  13. Are thiazides effective on hypertensive vertigo? A preliminary study.

    Science.gov (United States)

    Eryaman, Esra; Gökcan, Gökçen; Parmaksız, Ergün; Acar, Nurhan Ozdemir; Ozlüoğlu, Levent Naci

    2012-01-01

    In this study, we aimed to investigate whether the symptoms of vertigo related to hypertension resulted from endolymphatic hydrops and the efficacy of the thiazides in the treatment. A total of 24 vertigo patients without peripheric or central vestibular pathologies or hyperlipidemia were included. The study group comprised 15 patients with hypertension, including nine with regulated non-insulin-dependent diabetes mellitus (DM). The control group comprised nine patients without hypertension or DM. The patients in the study group received hydrochlorothiazide treatment. The European Evaluation of Vertigo Scale (EEVS) and Vertigo Handicap Questionnaire (VHQ), puretone audiometry, tympanometry, electronystagmography (ENG) for nystagmus tests, oculomotor tests, and caloric test were carried out initially and at three weeks for both groups. The results of the study group were compared to those of the control group. There was a statistically significant decrease in the scores of EEVS and VHQ at three weeks in the study group, compared to the baseline scores (for both groups p≤0.01). Our study results showed that thiazides alleviated vertigo symptoms in hypertensive patients, as measured by qualitative methods (i.e. EEVS, VHQ), but not with quantitative measurements (i.e. ENG).

  14. Anaerobic culture by Total Air Barrier: A preliminary study

    Directory of Open Access Journals (Sweden)

    Soma Sarkar

    2010-03-01

    Full Text Available BackgroundFor study with obligate anaerobes, inoculated platescontaining suitable reduced media need handling andincubation under strict anaerobic condition. Instead ofensuring a confined oxygen free chamber for placing seededplates, same purpose may be achieved by creating total airbarrier to the surface.MethodUpper moist surface of freshly prepared anaerobic media inPetri plates were intimately covered with very thintransparent bacteriological inert sterile polyester sheets.Stock culture of Bacteroides fragilis, ATCC 23745 andClostridium sporogenes, ATCC 11437 were grown in cookedmeat broth and then sub-cultured on respective plates, afterlifting the cover sheets. Sheets were again covered andincubated at 37oC ordinary incubator. To performantimicrobial susceptibility test, similarly covered seededplates with well inoculums were inverted en-block afterstripping sides with the help of a spatula. Now antibiotic diskswere placed on upper bare surfaces. After short pre-diffusion,plates were incubated keeping inoculated surface below.Same study was performed by conventional method usingGaspak.ResultsGood growths were noted in both sets of the study;however discrete colonies appeared more flat in nature intest set. Almost identical zones of inhibition were noted inboth sets of sensitivity study. Seven days old growths incovered blood agar plates were found viable when subculturedin cooked meat broths.ConclusionIsolation, identification and susceptibility study for mostclinically important obligate anaerobes may be performedby simple barrier method after appropriatestandardization.

  15. Preliminary cutting and drilling studies using new generation lasers

    International Nuclear Information System (INIS)

    Kautz, D.D.; Sze, J.S.; Dragon, E.P.; Hargrove, R.S.

    1992-01-01

    High power and radiance dye lasers developed at Lawrence Livermore National Laboratory show promise for material processing tanks. Evaluation using welding heat flow models suggest significant increases in precision and speed are expected. We developed tooling and instrumentation to diagnose important parameters including spot geometry and optical train quality. We started processing studies to determine the viability of these lasers of cutting and drilling. We used titanium alloys first in the studies due to the availability of comparable parametric studies in the technical literature. Results show that cuts and holes with extremely fine features can be made with dye lasers. The high radiance beam produces low distortion and small heat-affected zones. We have accomplished very high aspect ratios and micron scale kerfs and holes. Through continued system improvement and process optimization, we believe that submicron levels will be achieved

  16. Hydrogen Gas Retention and Release from WTP Vessels: Summary of Preliminary Studies

    Energy Technology Data Exchange (ETDEWEB)

    Gauglitz, Phillip A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bontha, Jagannadha R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Daniel, Richard C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mahoney, Lenna A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rassat, Scot D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wells, Beric E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bao, Jie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Boeringa, Gregory K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Buchmiller, William C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Burns, Carolyn A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chun, Jaehun [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Karri, Naveen K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Li, Huidong [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tran, Diana N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-01

    The Hanford Waste Treatment and Immobilization Plant (WTP) is currently being designed and constructed to pretreat and vitrify a large portion of the waste in the 177 underground waste storage tanks at the Hanford Site. A number of technical issues related to the design of the pretreatment facility (PTF) of the WTP have been identified. These issues must be resolved prior to the U.S. Department of Energy (DOE) Office of River Protection (ORP) reaching a decision to proceed with engineering, procurement, and construction activities for the PTF. One of the issues is Technical Issue T1 - Hydrogen Gas Release from Vessels (hereafter referred to as T1). The focus of T1 is identifying controls for hydrogen release and completing any testing required to close the technical issue. In advance of selecting specific controls for hydrogen gas safety, a number of preliminary technical studies were initiated to support anticipated future testing and to improve the understanding of hydrogen gas generation, retention, and release within PTF vessels. These activities supported the development of a plan defining an overall strategy and approach for addressing T1 and achieving technical endpoints identified for T1. Preliminary studies also supported the development of a test plan for conducting testing and analysis to support closing T1. Both of these plans were developed in advance of selecting specific controls, and in the course of working on T1 it was decided that the testing and analysis identified in the test plan were not immediately needed. However, planning activities and preliminary studies led to significant technical progress in a number of areas. This report summarizes the progress to date from the preliminary technical studies. The technical results in this report should not be used for WTP design or safety and hazards analyses and technical results are marked with the following statement: “Preliminary Technical Results for Planning – Not to be used for WTP Design

  17. Overeruption of teeth opposing removable partial dentures: a preliminary study.

    Science.gov (United States)

    Matsuda, Ken-Ichi; Miyashita, Yuji; Ikebe, Kazunori; Enoki, Kaori; Kurushima, Yuko; Mihara, Yusuke; Maeda, Yoshinobu

    2014-01-01

    One of the purposes of prosthodontic treatment is to prevent overeruption of opposing teeth, but there is currently minimal literature describing the efficacy of removable partial dentures (RPDs) in performing this function. This study investigated overeruption following RPD treatment. The study participants were 33 patients treated with RPDs, and overeruption was evaluated by comparing the surface computeraided design data of dental casts made at two different time points-before and after RPD treatment. Overeruption was observed in 38.1% of teeth opposed by the RPD, which was much less than the proportion of teeth that overerupted when not opposed by the RPD.

  18. Preliminary studies for the LHCb vertex detector vacuum system

    CERN Document Server

    Doets, M; Van Bakel, N; Van den Brand, J F J; van den Brand, Jo

    2000-01-01

    We lay down some general considerations which will serve as a starting point for design studies of a realistic LHCb vertex detector vacuum system. Based on these considerations, we propose a design strategy and identify issues to be further studied. In particular we try to outline some boundary conditions imposed by LHC and LHCb on the vacuum system. We discuss two possibilities for the LHCb vertex detector vacuum system. The preferred strategy uses a differentially pumped vacuum system with the silicon detectors separated from the beam line vacuum. Some estimations on static vacuum pressures and gas flows are presented.

  19. Theoretical provisions for the discharge at TJ-1 (Preliminary study)

    International Nuclear Information System (INIS)

    Guasp, J.

    1981-01-01

    Using the transport code PLASMATOR a numerical study about the TJ-1 discharge (a Tokamak close to be installed at JEN) has been made, observing the behaviour under huge variations on the transport coefficients as well as on density and current. Noteworthy a scaling law of the kind τ E ∼n θ has been contested at not too high density, The model insensibility upon the initial values has been confirmed and the effects of variations on the recycling coefficient and the rate rise of current studied too. Finally comparisons with alternative models have been accomplished. (Author) 29 refs

  20. Preliminary study on the effect of castration and testosterone ...

    African Journals Online (AJOL)

    To study the effect of castration and testosterone replacement on the testosterone level of the New Zealand rabbit, 16 apparently healthy adult male rabbits were used. The animals were divided into four groups with each group having four rabbits. The first group served as the control group. The rabbits in the second group ...

  1. The effect of chemotherapy on rat brain PET: preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Su; Kim, Il Han; Yu, A Ram; Park, Ji Ae; Woo, Sang Keun; Kim, Jong Guk; Cheon, Gi Jeong; Kim, Byeong Il; Choi, Chang Woon; Lim, Sang Moo; Kim, Hee Joung; Kim, Kyeong Min [Korea Institute Radiological and Medical Science, Seoul (Korea, Republic of)

    2010-10-15

    Chemotherapy was widely used for the therapy of cancer patients. When chemotherapy was performed, transient cognitive memory problem was occurred. This cognitive problem in brain was called as chemobrain. In this study, we have developed rat model for chemobrain. Cerebral glucose metabolism after chemotherapy was assessed using animal PET and voxel based statistical analysis method

  2. Psychiatric morbidity in oral lichen planus: A preliminary study

    Directory of Open Access Journals (Sweden)

    Abhishek Ranjan Pati

    2014-01-01

    Full Text Available Objective: To study the clinical types and association of psychological factors in patients with Oral Lichen Planus (OLP. Materials and Methods: An analytical age- and sex-matched study involved 30 patients with oral lichen planus (group 1 and 30 control subjects (group 2. We applied the following psychometric tests to both groups: General Health Questionnaire (GHQ and Hospital Anxiety and Depression Scale (HADS. Results: The patients with OLP were found to exhibit statistically significant higher anxiety, insomnia, and social dysfunction with the tests that were used (GHQ 24 and HADS than the control group (P > 0.05. The study group likewise exhibited greater depression and somatic symptoms. The mean total of the GHQ and HAD scores were found to be higher in the study group than in the controls (P > 0.05. Among the various types of OLP, patients with the erosive type had higher mean scores for anxiety and insomnia, social dysfunction and depression. Conclusion: In most patients psychiatric morbidity was strongly associated with OLP, which could support its role in the etiopathogenesis of the disease. The higher scores of the General Health Questionnaire and Hospital Anxiety and Depression Scale gave an insight into the hypothesis that psychological factors are associated with the causation of OLP.

  3. Stability notions in synthetic graph generation: a preliminary study

    NARCIS (Netherlands)

    van Leeuwen, W.; Fletcher, G.H.L.; Yakovets, N.; Bonifati, A.; Markl, Volker; Orlando, Salvatore; Mitschang, Bernhard

    2017-01-01

    With the rise in adoption of massive graph data, it be- comes increasingly important to design graph processing algorithms which have predictable behavior as the graph scales. This work presents an initial study of stability in the context of a schema-driven synthetic graph generation. Specifically,

  4. Market for small waste gasification projects - preliminary scoping study

    International Nuclear Information System (INIS)

    1999-01-01

    This report presents the findings of a market analysis for small waste gasification/pyrolysis plant in the UK. The overall objectives of the study are to assess the potential merits in establishing a demonstration plant in the UK, and to identify the size, profile and characteristics of the potential market based on municipal solid waste (MSW) feedstock. (author)

  5. Preliminary study on sterilization effect of irradiation on dry vegetable

    International Nuclear Information System (INIS)

    Zhai Jianqing; Bao Jianzhong; Cao Hong; Wang Jinrong; Chen Xiulan

    2004-01-01

    The number of surviving germs relationship to irradiation dose for several species dry vegetable was studied, and the original value D 10 of the dry vegetable was given. The value will provide a theoretical reference to ascertain the appropriate irradiation dose in the irradiation process of the dry vegetable

  6. Obstructive sleep apnea in epilepsy: a preliminary Egyptian study.

    Science.gov (United States)

    Shaheen, Hala A; Abd El-Kader, Ann A; El Gohary, Amira M; El-Fayoumy, Neveen M; Afifi, Lamia M

    2012-09-01

    The extent and clinical relevance of the association between epilepsy and sleep apnea are not previously studied in Egypt. What we wanted to know was the frequency of sleep apnea in Egyptian children with epilepsy and its influence on seizure frequency, other seizure characteristics, sleep complaint, and architecture. All patients with epilepsy, aged up to 18 years, who underwent polysomnography were studied. Patients with any neurological disease apart from epilepsy, with psychiatric illness, had hypnotics, or sedatives or those with liver or kidney failure were excluded from the study. The patients were divided into two subgroups according to apnea/hypopnea index: group (1) patients without obstructive sleep apnea (OSA) and group (2) patients with OSA. For control group, we choose 12 healthy individuals, with age and sex matched to that of our patients. We studied the clinical characteristics of epilepsy, sleep history, and polysomnographic recording of the patients with epilepsy and the control. EEG digital and video monitoring was done for all patients. Eleven patients (42.3%) were found to have obstructive sleep apnea. Seizure frequency was significantly higher in the patients with OSA. Apart from apnea and hypopnea indices, all other sleep parameters did not differ between patients' subgroups. Hypopnea index in REM positively correlates with number of awaking. Apnea index in REM positively correlates with latency to deep sleep and to periodic leg movement. Sleep apnea is frequent in patients with epilepsy. OSA may contribute to increase seizure frequency. We recommend investigating sleep apnea in all patients with epilepsy.

  7. A Preliminary Study on Bucket Foundations under Transient Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo; Nielsen, Søren Kjær

    2013-01-01

    This study aims at investigating the behaviour of monopod bucket foundations through a physical model. The foundation is installed in dense water-saturated sand and is subjected to lateral load applied at different rates. The different loading rates allow for exploring the patterns of response of...

  8. A Preliminary Trypanocidal Study of Natural and Synthetic ...

    African Journals Online (AJOL)

    Eighty healthy Wistar albino rats were used to investigate the trypanocidal effect of natural and synthetic supplements of zinc and magnesium in combination with diminazene aceturate in Trypanosoma congolense-inoculated rats. The rats were randomly divided into eight groups in study '1' (involving the natural ...

  9. Choosing the Adequate Level of Graded Readers--Preliminary Study

    Science.gov (United States)

    Prtljaga, Jelena; Palinkaševic, Radmila; Brkic, Jovana

    2015-01-01

    Graded readers have been used as second language teaching material since the end of the Second World War. They are an important source of simplified material which provides comprehensible input on all levels. It is of crucial importance for a successful usage of graded readers in the classroom and in studies which focus on graded readers, that an…

  10. The effect of chemotherapy on rat brain PET: preliminary study

    International Nuclear Information System (INIS)

    Kim, Jin Su; Kim, Il Han; Yu, A Ram; Park, Ji Ae; Woo, Sang Keun; Kim, Jong Guk; Cheon, Gi Jeong; Kim, Byeong Il; Choi, Chang Woon; Lim, Sang Moo; Kim, Hee Joung; Kim, Kyeong Min

    2010-01-01

    Chemotherapy was widely used for the therapy of cancer patients. When chemotherapy was performed, transient cognitive memory problem was occurred. This cognitive problem in brain was called as chemobrain. In this study, we have developed rat model for chemobrain. Cerebral glucose metabolism after chemotherapy was assessed using animal PET and voxel based statistical analysis method

  11. Preliminary Studies on the Development of Meat Balls | Igene ...

    African Journals Online (AJOL)

    The UUFB sample was rated highest in terms of overall likeness and may economically complement some of the existing popular meat-based snacks in Nigeria. The significance of the study is discussed. @JASEM Keyterms: Meat, Meat ball, Quality, Product development. J. Appl. Sci. Environ. Manage. June, 2012, Vol.

  12. Renal denervation by intravascular ultrasound: Preliminary in vivo study

    Science.gov (United States)

    Sinelnikov, Yegor; McClain, Steve; Zou, Yong; Smith, David; Warnking, Reinhard

    2012-10-01

    Ultrasound denervation has recently become a subject of intense research in connection with the treatment of complex medical conditions including neurological conditions, development of pain management, reproduction of skin sensation, neuropathic pain and spasticity. The objective of this study is to investigate the use of intravascular ultrasound to produce nerve damage in renal sympathetic nerves without significant injury to the renal artery. This technique may potentially be used to treat various medical conditions, such as hypertension. The study was approved by the Institutional Animal Care and Use Committee. Ultrasound was applied to renal nerves of the swine model for histopathological evaluation. Therapeutic ultrasound energy was delivered circumferentially by an intravascular catheter maneuvered into the renal arteries. Fluoroscopic imaging was conducted pre-and post-ultrasound treatment. Animals were recovered and euthanized up to 30 hours post procedure, followed by necropsy and tissue sample collection. Histopathological examination showed evidence of extensive damage to renal nerves, characterized by nuclear pyknosis, hyalinization of stroma and multifocal hemorrhages, with little or no damage to renal arteries. This study demonstrates the feasibility of intravascular ultrasound as a minimally invasive renal denervation technique. Further studies are necessary to evaluate the long-term safety and efficacy of this technique and its related clinical significance.

  13. Preliminary study Malaa. Final report; Foerstudie Malaa. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Factors of importance for a possible localization of a deep nuclear waste repository at Malaa in northern Sweden are mapped in this study. The geologic structures in the area have been reviewed, mostly from already existing knowledge. Existing infrastructure and necessary improvements are discussed, as well as land use and environment, employment and other social effects. 47 refs, 41 figs, 8 tabs.

  14. Burnout among Special Education Administrators: A Preliminary Study

    Science.gov (United States)

    Carter, Susan J.

    2011-01-01

    Research on the extent of stress and burnout among special education administrators is not as well developed as research on the extent of stress and burnout among teachers. This study utilized the Maslach Burnout Inventory to determine levels of stress and burnout among administrators of special education. Results indicated administrators of…

  15. Preliminary studies on ethanol production from Garcinia kola (bitter ...

    African Journals Online (AJOL)

    Dr. J. T. Ekanem

    A study on yeast fermentation of bitter kola pod( agricultural waste) was ... optimization of the ethanol production were investigated. ... components of biomass to produce a liquid .... Mani, S., Tabil, L. G. and Opoku, A. (2002). Ethanol from Agricultural crop residues-An. Overview. ... Effect of acid hydrolysis of Garcinia kola.

  16. Preliminary study on irradiation breeding of ornamental lotus

    International Nuclear Information System (INIS)

    Chen Xiulan; Bao Jianzhong; Liu Chungui; Cao Hong; Zhai Jianqing

    2004-01-01

    The effects of γ-ray irradiation on seeds and stems of ornamental lotus were studied. The results show that the mutation rate of seeds is higher than that of stems, and 30-60 Gy is the appropriate irradiation dose. The varieties with red or multi-color flower are more mutable than those with white flower. Two varieties were selected

  17. Preliminary Study on the Use of Urea Activated Melon ( Citrullus ...

    African Journals Online (AJOL)

    Adsorption studies were carried out using urea activated melon (Citrullus colocynthis) husks as a low-cost potential adsorbent to remove cadmium from industrial effluents. Bioabsorption parameters considered were as contact time, adsorbent dosage and adsorbate concentration. Cadmium removal was found to be ...

  18. Violence Prevention in Middle School: A Preliminary Study

    Science.gov (United States)

    KIllam, Wendy K.; Roland, Catherine B.; Weber, Bill

    2014-01-01

    Violence in schools continues reflecting violence within society. There is a growing need for violence prevention programs within the schools that provide students with the skills needed to cope with interpersonal and relationship is-sues effectively. This study was conducted at a middle school and there were 345 middle school students (6th to 8th…

  19. preliminary geological and radiometric studies of granitoids of zing

    African Journals Online (AJOL)

    DJFLEX

    laboratory of Geology Department, Federal University of. Technology, Yola where they were thin sectioned and petrographically studied using a high magnification polarising microscope. Canada balsam was used as the mounting medium. Radiometric survey was carried out using a McPhar model TC-33A portable gamma ...

  20. Advanced analysis of finger-tapping performance: a preliminary study.

    Science.gov (United States)

    Barut, Cağatay; Kızıltan, Erhan; Gelir, Ethem; Köktürk, Fürüzan

    2013-06-01

    The finger-tapping test is a commonly employed quantitative assessment tool used to measure motor performance in the upper extremities. This task is a complex motion that is affected by external stimuli, mood and health status. The complexity of this task is difficult to explain with a single average intertap-interval value (time difference between successive tappings) which only provides general information and neglects the temporal effects of the aforementioned factors. This study evaluated the time course of average intertap-interval values and the patterns of variation in both the right and left hands of right-handed subjects using a computer-based finger-tapping system. Cross sectional study. Thirty eight male individuals aged between 20 and 28 years (Mean±SD = 22.24±1.65) participated in the study. Participants were asked to perform single-finger-tapping test for 10 seconds of test period. Only the results of right-handed (RH) 35 participants were considered in this study. The test records the time of tapping and saves data as the time difference between successive tappings for further analysis. The average number of tappings and the temporal fluctuation patterns of the intertap-intervals were calculated and compared. The variations in the intertap-interval were evaluated with the best curve fit method. An average tapping speed or tapping rate can reliably be defined for a single-finger tapping test by analysing the graphically presented data of the number of tappings within the test period. However, a different presentation of the same data, namely the intertap-interval values, shows temporal variation as the number of tapping increases. Curve fitting applications indicate that the variation has a biphasic nature. The measures obtained in this study reflect the complex nature of the finger-tapping task and are suggested to provide reliable information regarding hand performance. Moreover, the equation reflects both the variations in and the general

  1. Gastroesophageal reflux disease in patients with diabetes: preliminary study.

    Science.gov (United States)

    Fujiwara, Mariko; Miwa, Takashi; Kawai, Takashi; Odawara, Masato

    2015-03-01

    Some studies report that complications of gastroesophageal reflux disease (GERD) occur more frequently in patients with diabetes mellitus (DM) than in non-diabetic patients. This study used transnasal endoscopy to elucidate the current status of concurrent GERD in patients with type 2 diabetes mellitus, and to examine the associations between intraesophageal pressure and GERD, as well as other neuropathic conditions. The study included 57 outpatients with type 2 diabetes mellitus. The mean age was 67 years and the duration of DM was 13 years. The mean hemoglobin A1c was 6.8%. Transnasal endoscopic evaluation items were (i) the presence or absence of esophagitis and its severity; (ii) intraesophageal pressure; and (iii) Helicobacter pylori status, which was evaluated by endoscopic findings, such as the presence or absence of gastritis and peptic ulcer, and by urea breath test. Of 57 patients, 24 (42.1%) were given a diagnosis of GERD based on endoscopy. Patients with concurrent GERD were younger, had shorter duration of DM, and were taller and heavier. Interestingly, no difference in body mass index was observed. There was no significant association between the presence of concurrent GERD and diabetic complications, including peripheral neuropathy, and infection or non-infection with H. pylori. Although there was no significant association between the presence of concurrent GERD and intraesophageal pressure values, we found aging, reduced estimated glomerular filtration rate, and the presence of autonomic nerve symptoms to correlate with reduced intraesophageal pressure. The results of this study could be used to answer the question of whether or not endoscopic GERD is a diabetic complication; however, further study is required. © 2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  2. Preliminary modulation transfer function study on amorphous silicon

    International Nuclear Information System (INIS)

    Khairul Anuar Mohd Salleh; Ab Razak Hamzah; Mohd Ashhar Khalid

    2006-01-01

    Modulation Transfer Function, (MTF) is the scientific means of evaluating the fundamental spatial resolution performance of an imaging system. In the study, the modulation transfer function of an amorphous silicon (aSi) sensor array is measured by using Edge Spread Function (ESF) Technique which is extracting a profile from the linearised image of the sharp edge. The Platinum foil is used to determine the ESF. The detector under study was a 2,304 (h) x 3,200 (v) total pixel matrix, 127 μm2 pixel pitch, 57% fill factor and using Gd2O2S:Tb Kodak Lanex Regular as the conversion screen. The ESF measurement is done by using 75 - 100 kV range of x-ray with constant mA. (Author)

  3. A PRELIMINARY STUDY OF HUMOUR IN ENGINEERING EDUCATION

    Directory of Open Access Journals (Sweden)

    SIOW C. LIM

    2017-01-01

    Full Text Available It is commonly known that humour has an implication on the process of teaching and learning. However, there is still limited study done on the implication of humour in teaching and learning engineering courses. This paper studies the perception and experience of engineering lecturers and students towards the incorporation of sense of humour in the teaching and learning of engineering courses. Online and offline surveys were conducted on the students and lecturers from the school of engineering, Taylors’ University respectively. Several interesting insights were drawn from the responses with the general consensus from both students and lecturers that humour helps in enhancing the teaching and learning process. Real case examples of how the lecturers deliver their lectures with humour were also presented.

  4. Preliminary questions before studying mild traumatic brain injury outcome.

    Science.gov (United States)

    Fayol, P; Carrière, H; Habonimana, D; Dumond, J-J

    2009-07-01

    To point out from the literature the issues in mild traumatic brain injury outcome. METHODOLOGY-RESULTS: The literature review allows to point out several different factors involved in the difficulty to study mild traumatic brain injury: mild traumatic brain injury definition, postconcussional syndrome definition, diagnosis threshold, severity and functional symptoms outcome, neuropsychological tests, unspecific syndrome feature, individual factors, confounding factors and treatment interventions. The mild traumatic brain injury outcome study is complicated by the definitions issues and especially their practical use and by the multiplicity and the intricate interrelationships among involved factors. The individual outcome and social cost weight is widely emphasized for an event still considered as medically trivial. The well-ordered preventive interventions necessity and the targeted treatment programs need for the persisting postconcussive symptoms complete our critical review.

  5. Sleep habits and patterns of college students: a preliminary study.

    Science.gov (United States)

    Buboltz, W C; Brown, F; Soper, B

    2001-11-01

    The negative effects of sleep difficulties have been well documented. However, the prevalence of such problems among US college students has not been well studied. Design difficulties are common in the limited number of existing investigations, making it difficult to estimates the prevalence and types of disturbance studied. The authors describe the use of a quantitative-based assessment instrument to provide an initial indication of students' sleep problems and to serve as a means of addressing some of the deficiencies in the literature. In their sample of 191 undergraduates at a rural southern university, they found that most of the students exhibited some form of sleep disturbance and that women, in general, reported more sleep disturbances than men did. They suggest how colleges and university officials can alter procedures to minimize students' sleep disturbances and reduce the deleterious effects of sleep problems on academic performance.

  6. Preliminary study of radioactive waste disposal in the vadose zone

    International Nuclear Information System (INIS)

    1978-09-01

    To investigate the characteristics of the vadose zone with respect to radioactive waste disposal, the mechanics of unsaturated flow in arid regions and the geohydrology of four areas with a deep water table were studied. The studies indicated that (1) arid sites with a water table deeper than 200 m can be found in at least three distinct geologic settings in the western United States, (2) the physics of unsaturated flow in soils and rock with interstitial porosity at low water contents, particularly under thermal gradients, is not yet completely understood, and (3) under certain conditions unsaturated flow can be so slow that analytic modeling of an unflawed repository is unnecessary to prove effective containment

  7. Mathematical preliminaries for a study of waves in a plasma

    International Nuclear Information System (INIS)

    Trocheris, M.

    1965-01-01

    This report contains the detailed proofs of mathematical results which are used in a study of the linear and 'quasi-linear' approximation for 'electrostatic' waves in a uniform plasma. Certain classes of functions of a complex variable, which are analytic in a strip parallel to the real axis, are defined and studied. In particular, properties of convergence of a sequence and of continuity with respect to a parameter are established for functions remaining inside one such class. The results are used to prove an existence theorem for the simplest equation in the quasi-linear theory of plasma waves. A number of elementary lemmas are used in the text and proved in an appendix. (author) [fr

  8. Primary prevention research: a preliminary review of program outcome studies.

    Science.gov (United States)

    Schaps, E; Churgin, S; Palley, C S; Takata, B; Cohen, A Y

    1980-07-01

    This article reviews 35 drug abuse prevention program evaluations employing drug-specific outcome measures. Many of these evaluations assessed the effects of "new generation" prevention strategies: affective, peer-oriented, and multidimensional approaches. Only 14 studies evaluated purely informational programs. Evaluations were analyzed to ascertain (1) characteristics of the programs under study, (2) characteristics of the research designs, and (3) patterns among findings. This review provides some evidence that the newer prevention strategies may produce more positive and fewer negative outcomes than did older drug information approaches. Over 70% of the programs using the newer strategies produced some positive effects; only 29% showed negative effects. In contrast, 46% of informational programs showed positive effects; 46% showed negative effects. These findings must be approached with great caution, since the research was frequently scientifically inadequate, and since rigor of research was negatively correlated with intensity and duration of program services.

  9. Preliminary study of radioactive waste disposal in the vadose zone

    Energy Technology Data Exchange (ETDEWEB)

    1978-09-01

    To investigate the characteristics of the vadose zone with respect to radioactive waste disposal, the mechanics of unsaturated flow in arid regions and the geohydrology of four areas with a deep water table were studied. The studies indicated that (1) arid sites with a water table deeper than 200 m can be found in at least three distinct geologic settings in the western United States, (2) the physics of unsaturated flow in soils and rock with interstitial porosity at low water contents, particularly under thermal gradients, is not yet completely understood, and (3) under certain conditions unsaturated flow can be so slow that analytic modeling of an unflawed repository is unnecessary to prove effective containment.

  10. V. PRELIMINARY STUDY ON ISOZYMES OF SHOREA JAVANICA

    Directory of Open Access Journals (Sweden)

    U. JUNIARTI and M. I. J. UMBOH

    1987-01-01

    Full Text Available The detection of genetic variability in natural or man-made populations/ plantations is useful in both basic and applied biology. In addition to the various facets of studies on Shorea javanica already initiated by Torquebiau (1984 and alongside with his recommendations on focus for future research, a study on the genetic aspects of the species should be given important considerations. As the trees are tapped for resin, an important forest product, the genetic basis of the production as well as the range of variation in amount of resin production among t he trees must be known. Coupled with this is a thorough investigation on the differences in pest resistance/susceptability among the trees and their genetic basis. While the assumption (Torquebiau 1984 that trees in natural forest areas are-rarely attacked by diseases because of mycorrhizal fungi is interesting, its confirmation is necessary. If this is true, problems would arise when plants are introduced into a new plantation site as experienced by the Forest Research Institute (Ardikoesuma 1954. Thus, we need to look for pest resistant plants i.e. those that can remain healthy even in the absence of mycorrhizae. The above studies on possible genetic variation could give vital information for development of forest plantations of the species and for breeding and tree improvement strategies. By knowing the extent of genetic variation in natural population or in plantations one could be guided to maintain or increase the genetic base in these areas. Biochemical characters such as isozyme banding patterns have been useful in several areas of plant biology, population genetics, evolution and breeding. Isozymes are detected by starch gel electrophoresis and when their genetic control is established, they could be genetic markers in analyzing variation in morphological or physiological characters. The present study is an attempt to detect the isozymes in leaves, seeds and cotyledons of Shorea

  11. Preliminary manual of the wind farms impacts study

    International Nuclear Information System (INIS)

    2000-11-01

    This document aims to present and propose tools and methods allowing the improve the environmental quality of the future wind farms projects. After a presentation of general notions on the wind farms and the economy of the wind energy, it presents the regulation and the procedures concerning the environmental impact. It proposes then the main possible effects and the impacts study themes. (A.L.B.)

  12. Preliminary Studies on the Occurrence of Stem Borers and the ...

    African Journals Online (AJOL)

    A field experiment was carried out to study the occurrence of stem-borers and the incidence of stalk rot under varying population densities (64,000, 32,000, and 21,333 plants/ha) of two common cultivars (TZSR-Y and DMRZ-Y) of maize. Whereas the percentage of plants with stem borers infestation and those with stem ...

  13. Preliminary study of coach verbal behaviour according to game actions

    OpenAIRE

    Guzmán Luján, José Francisco; Calpe Gómez, Vicente

    2012-01-01

    The aim of this study was to analyse the interaction between game actions in high-level handball and verbal behaviour performed by the coach. For this purpose, a match of the 1st National Division of male Spanish handball was analysed. The type of behaviour and the content of the message reported by the coach were recorded using a modified version of Coaching Behaviour Assessment System (CBAS) and Coach Analysis and Intervention System (CAIS). About game actions, they were grouped into positi...

  14. Preliminary study of the heating market in Sweden

    International Nuclear Information System (INIS)

    1999-01-01

    The successive deregulation of the market for electric power, in Sweden as well as abroad, results in an increased competition in generation and trade of electricity. This market that previously was known for its oligopoly in the production sector and its monopoly in the distribution sector has now been opened for competition. This study is focused on the district heating sector, because it is still comparatively unregulated, and because it partly comprises what is called natural monopolies

  15. PRELIMINARY STUDY OF HEMATOLOGICAL PARAMETERS IN HERZEGOVINIAN DONKEY

    Directory of Open Access Journals (Sweden)

    Dunja Rukavina

    2016-02-01

    Full Text Available Herzegovinian donkey is a very important animal resource of Bosnia and Herzegovina. There have been no works attempted at determining the normal values of hematological parameters of Herzegovinian donkey. For this reason, the objective of the present study was to investigate some hematological parameters in Herzegovinian donkey. The research was performed on 30 apparently healthy donkeys (18 female and 12 male of ages from 1 to 20 years. Blood samples (3 ml were obtained by jugular vein puncture (vena jugularis externa in vacuum tubes with EDTA. The mean value of hematocrit was 29.19 %, hemoglobin concentration 10.6 g/dl, mean corpuscular hemoglobin concentration 36.33 g/dl, white blood cells 9.33 x109/L, granulocytes (109/L 5.45 x109/L, granulocytes (% 59.47%, lymphocyte/monocyte (109/L 3.89 x109/L, lymphocyte/monocyte (% 40.53% and platelet cells 148.97 x109/L. Parameters were determined using an automated analyzer IDEXX QBC VET AutoRead. Data were analyzed by SPSS V 15. All hematological parameters (except platelet cells were consistent with the recommended reference ranges for donkeys, and the values found in literature so far. Platelet cells values were much lower than in the literature for the other donkey breeds and the recommended reference ranges for donkeys. The slight differences found between our results and those reported in the previous works confirm the need for further studies to investigate the reference values of hematological parameters of Herzegovinian donkey. This work is a contribution to the study of hematological parameters of Herzegovinian donkey, and we expect these data to be applied to the further studies.

  16. Preliminary Problem Definition Study on Munitions-Related Chemicals.

    Science.gov (United States)

    1979-04-01

    Thorium-230, Radium-226, Lead- 210 and Polonium - 210 by Plants," Radiat. Bot., 10(3), 293-295. Ernst, W. (1968), "Ecological Studies on Plants Grown on...dechlorane in the environment and its bioconcentration and biomagnifica- tion through the food chain. In mammals, dechlorane has been shown to be tei-atogenic...08 5. Phytotoxicity .o......................208 *6. Environmental Fate ....................... 210 7. Availability of Literature for

  17. High-repetition-rate hydrogen chamber: Preliminary studies

    International Nuclear Information System (INIS)

    1967-01-01

    This report is a conclusion to the tests realised with an experimental bubbles chamber in view to study the possibilities to increase the repetition rate. The more important parameters (the evolution of the bubbles, the expansion system) are considered in a theoretical way. Then the hardware is described. To end, experimental results are compared with the first evaluations. The calculations and the experimentation are against an oscillation system for the expansion. A system with a locking is to he considered. (authors) [fr

  18. Preliminary study of MR elastography in brain tumors

    International Nuclear Information System (INIS)

    Xu Lei; Gao Peiyi; Lin Yan; Han Jiancheng; Xi Zhinong; Shen Hao

    2008-01-01

    Objective: To investigate the potential values of magnetic resonance elastography (MRE) for evaluating the brain tumor consistency in vivo. Methods: Fourteen patients with known solid brain tumor (5 male, 9 female; age range: 16-63 years) underwent brain MRE studies. Informed consent was obtained from all patients. A dedicated external force actuator for brain MRE study was developed. The actuator was fixed to the head coil. During scan, one side of the actuator was attached to the patients' head. Low frequency oscillation was produced by the actuator and caused shear waves propagating into brain tissue. The pulse sequence used in the study was phase-contrast gradient-echo sequence. Phase images of the brain were obtained and the shear waves within the brain were directly imaged. Phase images were processed with local frequency estimation (LFE) technique to obtain the elasticity image. Consistency of brain tumors was evaluated at surgery and was classified as soft, intermediate, or hard with comparison to the white matter of the brain. Correspondence of MRE evaluation with operative results was studied. Results: The elastic modulus of the tumor was lower than that of white matter in 1 patient, higher in 11 patients, and similar in 2 patients. At surgery, the tumor manifested a soft consistency in 1 patient, hard consistency in 11 patients, intermediate consistency in 2 patients. The elasticity of tumors in 14 patients evaluated by MRE was correlated with the tumor consistency on the operation. Conclusion: MRE can noninvasively display the elasticity of brain tumors in vivo, and evaluate the brain tumor consistency before operation. (authors)

  19. Potential of ricehull communal power generation in the Philippines - a preliminary study

    International Nuclear Information System (INIS)

    Bernardo, J.Y.; Navarro, L.B.; Abito, G.F.; Lim, B.P.

    1992-01-01

    The preliminary feasibility study of utilizing ricehulls as fuel for power generation in a communal set-up involving ricemills was completed by PNOC-ERDC for the EC-AIT COGEN Programme. The study assessed the market, evaluated the patterns and level of ricehull availability, and their implications on plant operation characteristics and financial viability. Ten potential areas were studied more closely for their suitability as pilot demonstration sites. (auth.). 8 tabs.; 4 figs.; 1 ref

  20. Infrastructure Joint Venture Projects in Malaysia: A Preliminary Study

    Science.gov (United States)

    Romeli, Norsyakilah; Muhamad Halil, Faridah; Ismail, Faridah; Sufian Hasim, Muhammad

    2018-03-01

    As many developed country practise, the function of the infrastructure is to connect the each region of Malaysia holistically and infrastructure is an investment network projects such as transportation water and sewerage, power, communication and irrigations system. Hence, a billions allocations of government income reserved for the sake of the infrastructure development. Towards a successful infrastructure development, a joint venture approach has been promotes by 2016 in one of the government thrust in Construction Industry Transformation Plan which encourage the internationalisation among contractors. However, there is depletion in information on the actual practise of the infrastructure joint venture projects in Malaysia. Therefore, this study attempt to explore the real application of the joint venture in Malaysian infrastructure projects. Using the questionnaire survey, a set of survey question distributed to the targeted respondents. The survey contained three section which the sections are respondent details, organizations background and project capital in infrastructure joint venture project. The results recorded and analyse using SPSS software. The contractors stated that they have implemented the joint venture practice with mostly the client with the usual construction period of the infrastructure project are more than 5 years. Other than that, the study indicates that there are problems in the joint venture project in the perspective of the project capital and the railway infrastructure should be given a highlights in future study due to its high significant in term of cost and technical issues.

  1. Infrastructure Joint Venture Projects in Malaysia: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Romeli Norsyakilah

    2018-01-01

    Full Text Available As many developed country practise, the function of the infrastructure is to connect the each region of Malaysia holistically and infrastructure is an investment network projects such as transportation water and sewerage, power, communication and irrigations system. Hence, a billions allocations of government income reserved for the sake of the infrastructure development. Towards a successful infrastructure development, a joint venture approach has been promotes by 2016 in one of the government thrust in Construction Industry Transformation Plan which encourage the internationalisation among contractors. However, there is depletion in information on the actual practise of the infrastructure joint venture projects in Malaysia. Therefore, this study attempt to explore the real application of the joint venture in Malaysian infrastructure projects. Using the questionnaire survey, a set of survey question distributed to the targeted respondents. The survey contained three section which the sections are respondent details, organizations background and project capital in infrastructure joint venture project. The results recorded and analyse using SPSS software. The contractors stated that they have implemented the joint venture practice with mostly the client with the usual construction period of the infrastructure project are more than 5 years. Other than that, the study indicates that there are problems in the joint venture project in the perspective of the project capital and the railway infrastructure should be given a highlights in future study due to its high significant in term of cost and technical issues.

  2. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    1Maryam Kazemi

    2013-11-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan. Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  3. Preliminary study for pixel identification on a modular gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Soluri, A., E-mail: soluri@isib.cnr.it; Atzeni, G.; Ucci, A.; Cusanno, F.; Massari, R.

    2014-02-01

    Our group has recently investigated and produced new scintigraphic prototypes based on advanced scintillation structure. The aim of this study is to demonstrate the use of scintillation matrices with size equal to the overall area of the Position Sensitive Photomultiplier Tube (PSPMT), to design a modular gamma camera and study the solution of the dead area problems optimizing the overall pixel identification. In this paper we investigate the response of different combinations with crystals integrated within tungsten structure, coupled with H8500, R8900-C12 and R11265-M64 Hamamatsu PSPMTs. Several scintillation matrices, whose dimensions match to the physical area of the PSPMT, have been analysed so that we have also studied limits of detection for the elements of the matrix in the critical zones of the PSPMT, i.e. corners and borders. In order to enhance the detectability of scintillation elements we improved the light collection by depositing metallic layers or treating the tungsten structure with different coating materials, and shaping the external elements of the scintillation matrices. The results have shown good energy resolution and the proposed method can be applied in medical imaging for obtaining high efficiency scintillation devices.

  4. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    Maryam Kazemi

    2013-12-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan.  Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  5. FAIR imaging of the liver. A preliminary study

    International Nuclear Information System (INIS)

    Kiryu, Shigeru; Machida, Toru; Noda, Masanobu

    1998-01-01

    Flow-sensitive alternating inversion recovery (FAIR) technique has recently been introduced for perfusion or functional MR studies of the brain. In the imaging of liver neoplasms, the evaluation of tumor vascularity is important for diagnosis, and therefore the FAIR technique may potentially complement liver MR imaging. The purpose of this study was to evaluate the usefulness of a FAIR sequence in MR imaging of the liver and to compare it with arterial-phase images of dynamic MR imaging. One volunteer and six patients with focal hepatic lesions (one with hepatocellular carcinoma (HCC), three with metastasis, and two with cavernous hemangioma) underwent FAIR. Short TI (600 ms) and long TI (1200 ms) images were obtained during breath-hold. In normal volunteers, the vessels generated remarkably bright signal in both short and long TI. Signal intensity of liver parenchyma was low in short TI, and became stronger in long TI. Two HCC (in one patient) (100%), one hemangioma (50%), and three metastases (100%) were well delineated as bright lesions. One HCC produced peripheral high intensity in short-TI FAIR image, and this finding was consistent with the result of dynamic MR study. Another HCC, which showed no clear enhancement in the arterial-phase dynamic MRI, was visualized only in long-TI FAIR. One hemangioma, which was clearly seen in FAIR image, showed rapid and strong enhancement on dynamic MRI. It is concluded that FAIR is a promising technique for evaluation of vascularity of hepatic tumors without using contrast materials. (author)

  6. Effects of Omeprazole on Iron Absorption: Preliminary Study

    Directory of Open Access Journals (Sweden)

    Mahmut Yaşar Çeliker

    2013-09-01

    Full Text Available Objective: Increasing numbers of pediatric and adult patients are being treated with proton pump inhibitors (PPIs. PPIs are known to inhibit gastric acid secretion. Nonheme iron requires gastric acid for conversion to the ferrous form for absorption. Ninety percent of dietary and 100% of oral iron therapy is in the nonheme form. To the best of our knowledge, the effect of PPIs on iron absorption has not been studied in humans. Our study assessed the relationship between omeprazole therapy and iron absorption in healthy subjects. Materials and Methods: We recruited 9 healthy volunteers between June 2010 and March 2011. Subjects with chronic illness, anemia, or use of PPI therapy were excluded. Serum iron concentrations were measured 1, 2, and 3 h after the ingestion of iron (control group. The measurements were repeated on a subsequent visit after 4 daily oral administrations of omeprazole at a dose of 40 mg (treatment group. Results: One female and 8 male volunteers were enrolled in the study with a mean age of 33 years. There was no statistical difference detected between baseline, 1-h, 2-h, and 3-h iron levels between control and treatment groups. Conclusion: Administration of omeprazole for a short duration does not affect absorption of orally administered iron in healthy individuals.

  7. Determination of PCDDs in spider webs: preliminary studies

    Science.gov (United States)

    Rybak, Justyna; Rutkowski, Radosław

    2018-01-01

    The application of spider webs for determination of polichlorinated dibenzo-para-dioxins (PCDDs) has been studied for the first time. The aim of the studies was to find out if spider webs are suitable for such examinations as it was proved in the previous research they are excellent indicators of air pollutants. Spiders are ubiquitous, thus collection of samples is easy and non-invasive. Studies were conducted within the city of Wrocław and surroundings, one of the biggest and at the same time heaviest polluted city in Poland. Five research sites have been chosen, where spider webs were collected after 60 days of continuous exposure time. Webs belonging to two genera Tegenaria sylvestris and Tegenaria ferruginea (family Agelenidae) have been chosen as they are large and very dense, thus they are very suitable for such examinations. Webs were found to retain dioxins probably mainly by external exposure. These promising results should be continued and expanded in the future research.

  8. Preliminary Study of Mental Retardation in Rovira (Tolima, Colombia

    Directory of Open Access Journals (Sweden)

    Luis Gustavo Celis

    2008-07-01

    Full Text Available limitationsin performance, significant deficiencyin intelligence and adaptative behavior, causingclinical and social disability. Most patients withmental retardation in Colombia do not receiveclinical genetics evaluation. The aims of thepresent study are to evaluate and characterizea group of patients with mental retardationfrom the population of Rovira. The presentstudy included twenty five patients with mentalretardation from Rovira (Tolima whichwere studied by clinical examination, metabolicscreening (ferric chloride, nitrosonaphtol,silver nitroprusiate, dinitrophenylhydrazineand benedict and cytogenetics (G-Bandingkariotype. Pesticide detection was perfomedby random sampling of water and tomatoes intwenty different places of water distribution,the center of the town and crop fields. A familywith three affected sibs (two females, onemale with mental retardation was identified,suggesting a genetic component. Metabolicscreening was negative and karyotypes werenormal. The analyses performed for organophosphateswere positive in 100% of the samples.Carbamates were positive in 60% of thewater source and 100% of tomato samples. Allthe samples tested were negative for organochlorides.Further studies as molecular fragile-X test, will be performed.

  9. Protocol Development and Preliminary Toxicity Study of CBRN Nanomaterials

    Science.gov (United States)

    2013-12-05

    FBS) were purchased from ATCC and used for growing cells. 5.2.3 Positive Control The positive control, sodium lauryl sulfate (SLS), (Cat. # 71736 for 10...Inc.; New Castle, DE). Toxicology Study No. 87-XE-0EJ5-11 (FY12 Continuation) 5 5.1.2 Positive Control Zinc sulfate is recommended as a standard or...Inc.(Austin, TX). • Nano Sodium Bicarbonate is a component in the formulation being investigated as a replacement fire extinguishing agent for the Halon

  10. Preliminary studies on the closed cycle magneto aerodynamic converter

    International Nuclear Information System (INIS)

    Ricateau, P.

    1964-01-01

    Besides the open cycle MHD converters which convert the thermal energy contained in combustion gases, a closed cycle converter which can work with any high temperature heat source and specially with nuclear sources is being very carefully studied. Before proceeding to a practical study of the power station as a whole the performances of the converter itself must be fully investigated. These performances are largely a function of the conductivity of the gas, but this conductivity must not be repaid by a temperature technically unacceptable for the heat exchanger. In the conversion fluid an ionizable seeding vapour such as caesium or potassium is mixed with a carrier gas, helium or argon. Purely thermal ionization is only efficient above 2 500 deg. K, whereas the electric field obtained by Induction in the converter can, under given conditions, increase the electron temperature and produce an ionization rate well above the equilibrium value. This allows the gas to be ionized at moderate temperature. Studies are under way in order to clarify the conditions required to produce extra-thermal ionization in seeded rare gases. Measurements have been performed with a 3-phase 500 kVA plasmatron with potassium-seeded argon. The outgoing gas is fed into a channel where the tensor components of conductivity are measured in the presence of a magnetic field. The values found under thermodynamic equilibrium conditions confirm the simple theory. This is not the case when the electrons are heated. Measurements of the same kind have been made by another method in caesium-seeded helium contained in an isothermal vessel at 1 900 deg. K. There also the equilibrium values are in good agreement, but non-equilibrium ionization seems to be lower than expected. The effect of electron heating inside the converter in the case of argon-. potassium mixture has been considered in a theoretical study. It is shown that the electrode set must be carefully subdivided along the channel, and that

  11. ANAEROBIC MEMBRANE BIOREACTORS FOR DOMESTIC WASTEWATER TREATMENT. PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    Luisa Vera

    2014-12-01

    Full Text Available The operation of submerged anaerobic membrane bioreactors (SAnMBRs for domestic wastewaters treatment was studied in laboratory scale, with the objective to define sustainable filtration conditions of the suspensions along the process. During continuous experiments, the organic matter degradation by anaerobic way showed an average DQOT removal of 85% and 93%. Indeed, the degradation generated biogas after 12 days of operation and its relative methane composition was of 60% after 25 days of operation. Additionally, the comparison between membrane bioreactors (MBRs performance in aerobic and anaerobic conditions in filterability terms, reported that both systems behave similarly once reached the stationary state.

  12. Preliminary study of post mortem identification using lip prints.

    Science.gov (United States)

    Utsuno, Hajime; Kanoh, Takashi; Tadokoro, Osamu; Inoue, Katsuhiro

    2005-05-10

    Identification using lip prints was first performed in the 1950s and was the subject of much research in the 1960s and 70s, leading to the acceptance of this technique as evidence in the criminal justice system. Previous research has focused on identifying lip print types or on methods of obtaining hidden lip prints left at the crime scene. The present study aimed to clarify characteristics of lip prints from cadavers with various causes of death (including drowning and hanging) and to determine the effects of fixation on post mortem changes in lip impressions.

  13. Health Anxiety in Young Indonesian Adults: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Venie Viktoria Rondang Maulina

    2018-05-01

    Full Text Available In young adulthood most people begin to realize the meaning of health. The amount of costs to be incurred for the treatment of a person when they are suffering from a disease also affects a person's health concern. According to Taylor and Asmundson (2004, most people feel anxious about their health. Anxiety about health can differ from one person to another. Through this study a general overview of health anxiety for young adults in Indonesia, especially in Jakarta, can be seen. Participants in this study consisted of 263 people, aged 20-40 years (M = 27.23 , SD = 5.50. Sociodemographic variables include ages, gender, and marital status, level of education, employment status, and ethnicity. Researcher used Short Health Anxiety Inventory (SHAI; Salkovskis, Rimes, & Warwick, 2002, Patient Health Questionnaire Somatic Symptom Severity Scale (PHQ-15; Kroenke, Spitzer, & William, 2002. For data analysis, researcher used The Pearson Product Moment Correlation. The results showed significant correlation between health anxiety and somatic symptoms.

  14. Zero emission city. Preliminary study; Null-Emissions-Stadt. Sondierungsstudie

    Energy Technology Data Exchange (ETDEWEB)

    Diefenbach, N; Enseling, A; Werner, P; Flade, A; Greiff, R; Hennings, D; Muehlich, E; Wullkopf, U; Sturm, P; Kieslich, W; Born, R; Grossklos, M; Hatteh, R; Mueller, K; Ratschow, A; Valouch-Fornoff, C

    2002-10-01

    The idea of a 'zero emission city' is investigated by the Institut Wohnen und Umwelt on behalf of the Federal Minister of Education and Research. After describing the current situation and defining the key parameters of a 'zero emission city', settlement structures, power supply, production processes and transportation are analyzed and linked with the communal action level to obtain a framework for research, activities and actions. The study ends with recommendations for a research programme 'zero emission city'. (orig.) [German] Die von den Staedten der Industrielaender ausgehenden Emissionen stellen im Hinblick auf die globalen Belastungen wie z.B. Treibhauseffekt, Ozonabbau und Versauerung das Hauptproblem dar. Aus diesem Grunde bietet es sich an, den Gedanken der 'Null-Emissions-Stadt', der Vision einer moeglichst emissionsfreien Stadt, aufzugreifen und auf seine Tragfaehigkeit fuer innovative Handlungsmodelle forschungsstrategisch zu ueberpruefen. Das Bundesministerium fuer Bildung und Forschung hat das Institut Wohnen und Umwelt beauftragt, in einer Sondierungsstudie dieser Fragestellung nachzugehen. Nach der Festlegung der Ausgangsbedingungen und Eckpunkte der Vision 'Null-Emissions-Stadt' und der Analyse der vier Handlungsfelder Siedlungsstrukturen, Energieversorgung, Produktionsprozesse (Kreislaufwirtschaft) und Verkehr werden diese aufgegriffen und mit der kommunalen Handlungsebene verknuepft und zu einem Forschungs-, Handlungs- und moeglichen Aktionsrahmen zusammengefuegt. Die Studie schliesst mit Hinweisen fuer die Gestaltung eines Forschungsprogramms 'Null-Emissions-Stadt'. (orig.)

  15. Cardiac pathology in chronic alcoholics: A preliminary study

    Directory of Open Access Journals (Sweden)

    P Vaideeswar

    2014-01-01

    Full Text Available Background: Ethyl alcohol exerts both positive and negative effects on the cardiovascular system. Alcoholic cardiomyopathy, produced by direct or indirect mechanisms, is well-documented. An important, but seldom appreciated effect is an increase in iron deposition in the myocardium, which can add to the cardiac dysfunction. The present study was planned to document the pathological features and iron levels in the cardiac tissue of patients who were chronic alcoholics and correlate these characteristics with the liver pathology and iron content. Materials and Methods: An autopsy-based prospective study of 40 consecutive patients compared with ten age matched controls (no history of alcohol intake. Histopathological changes like the morphology of the cardiac myocytes, degree of fibrosis (interstitial, interfiber, perivascular, and replacement, presence of inflammatory cells, increased capillary network, and adipose tissue deposition were noted and graded. These were also correlated with the liver pathology. The iron content in the heart and liver were measured by using calorimetry. Results: All cases had increased epicardial adipose tissue with epicardial and endocardial fibrosis, prominence of interstitial and interfiber fibrosis, myofiber degeneration, and increased capillary network; this was particularly prominent in patients with cirrhosis. Elemental iron level in heart tissue was raised in the cases relative to controls. Conclusions: Alcohol produces subclinical changes in the myocardium, with an increased iron content, which may be the forerunner for subsequent clinical cardiac dysfunction.

  16. Preliminary study on hydrogeology in tectonically active areas

    International Nuclear Information System (INIS)

    Lowry, Thomas Stephen; Lappin, Allen R.; Gettemy, Glen L.; Jensen, Richard Pearson; Arnold, Bill Walter; James, Scott Carlton; Lee, Moo Yul; Meier, Diane A.

    2006-01-01

    This report represents the final product of a background literature review conducted for the Nuclear Waste Management Organization of Japan (NUMO) by Sandia National Laboratories, Albuquerque, New Mexico, USA. Internationally, research of hydrological and transport processes in the context of high level waste (HLW) repository performance, has been extensive. However, most of these studies have been conducted for sites that are within tectonically stable regions. Therefore, in support of NUMO's goal of selecting a site for a HLW repository, this literature review has been conducted to assess the applicability of the output from some of these studies to the geological environment in Japan. Specifically, this review consists of two main tasks. The first was to review the major documents of the main HLW repository programs around the world to identify the most important hydrologic and transport parameters and processes relevant in each of these programs. The review was to assess the relative importance of processes and measured parameters to site characterization by interpretation of existing sensitivity analyses and expert judgment in these documents. The second task was to convene a workshop to discuss the findings of Task 1 and to prioritize hydrologic and transport parameters in the context of the geology of Japan. This report details the results and conclusions of both of these Tasks

  17. Zero emission city. Preliminary study; Null-Emissions-Stadt. Sondierungsstudie

    Energy Technology Data Exchange (ETDEWEB)

    Diefenbach, N.; Enseling, A.; Werner, P.; Flade, A.; Greiff, R.; Hennings, D.; Muehlich, E.; Wullkopf, U.; Sturm, P.; Kieslich, W.; Born, R.; Grossklos, M.; Hatteh, R.; Mueller, K.; Ratschow, A.; Valouch-Fornoff, C.

    2002-10-01

    The idea of a 'zero emission city' is investigated by the Institut Wohnen und Umwelt on behalf of the Federal Minister of Education and Research. After describing the current situation and defining the key parameters of a 'zero emission city', settlement structures, power supply, production processes and transportation are analyzed and linked with the communal action level to obtain a framework for research, activities and actions. The study ends with recommendations for a research programme 'zero emission city'. (orig.) [German] Die von den Staedten der Industrielaender ausgehenden Emissionen stellen im Hinblick auf die globalen Belastungen wie z.B. Treibhauseffekt, Ozonabbau und Versauerung das Hauptproblem dar. Aus diesem Grunde bietet es sich an, den Gedanken der 'Null-Emissions-Stadt', der Vision einer moeglichst emissionsfreien Stadt, aufzugreifen und auf seine Tragfaehigkeit fuer innovative Handlungsmodelle forschungsstrategisch zu ueberpruefen. Das Bundesministerium fuer Bildung und Forschung hat das Institut Wohnen und Umwelt beauftragt, in einer Sondierungsstudie dieser Fragestellung nachzugehen. Nach der Festlegung der Ausgangsbedingungen und Eckpunkte der Vision 'Null-Emissions-Stadt' und der Analyse der vier Handlungsfelder Siedlungsstrukturen, Energieversorgung, Produktionsprozesse (Kreislaufwirtschaft) und Verkehr werden diese aufgegriffen und mit der kommunalen Handlungsebene verknuepft und zu einem Forschungs-, Handlungs- und moeglichen Aktionsrahmen zusammengefuegt. Die Studie schliesst mit Hinweisen fuer die Gestaltung eines Forschungsprogramms 'Null-Emissions-Stadt'. (orig.)

  18. Effects of vibrotactile vestibular substitution on vestibular rehabilitation - preliminary study,

    Directory of Open Access Journals (Sweden)

    Cibele Brugnera

    2015-12-01

    Full Text Available ABSTRACT INTRODUCTION: Some patients with severe impairment of body balance do not obtain adequate improvement from vestibular rehabilitation (VR. OBJECTIVE: To evaluate the effectiveness of Vertiguard(tm biofeedback equipment as a sensory substitution (SS of the vestibular system in patients who did not obtain sufficient improvement from VR. METHODS: This was a randomized prospective clinical study. Thirteen patients without satisfactory response to conventional VR were randomized into a study group (SG, which received the vibrotactile stimulus from Vertiguard(tm for ten days, and a control group (CG, which used equipment without the stimulus. For pre- and post-treatment assessment, the Sensory Organization Test (SOT protocol of the Computerized Dynamic Posturography (CDP and two scales of balance self-perception, Activities-specific Balance Confidence (ABC and Dizziness Handicap Inventory (DHI, were used. RESULTS: After treatment, only the SG showed statistically significant improvement in C5 (p = 0.007 and C6 (p = 0.01. On the ABC scale, there was a significant difference in the SG (p= 0.04. The DHI showed a significant difference in CG and SG with regard to the physical aspect, and only in the SG for the functional aspect (p = 0.04. CONCLUSION: The present findings show that sensory substitution using the vibrotactile stimulus of the Vertiguard(tm system helped with the integration of neural networks involved in maintaining posture, improving the strategies used in the recovery of body balance.

  19. Network connection of distributed electricity production - a preliminary study

    International Nuclear Information System (INIS)

    Pleym, Anngjerd; Mogstad, Olve

    2002-01-01

    It will be necessary to lower the barriers for utilisation of distributed energy sources in order to increase the use of such sources in Norway. A relatively extensive R and D activity would be required for reaching this goal. Available Norwegian and international guidelines and technical requirements with respect to network connection of the distributed energy sources are studied with the aim of exposing needs for further R and D initiatives. A limited monitor is also carried out among the Norwegian network businesses with distributed units in their networks. The results show that the main focus in the R and D activities has drifted away from establishing guidelines for technical requirements for network coupling. Some verification work remains in investigating the usefulness of the existing international and the specific commercial network guidelines. For the network industry the main focus must be on the two following areas: 1) How will large concentrations of distributed production units connected to the same network influence the voltage quality and the delivery reliability in the networks. 2) How can the network businesses employ the distributed production units in their networks. A Nordic project (Finland, Sweden, Norway) which will study these problems is being established. Large national scientific institutions will be involved. The executive committee will consist of representatives from Finenergy, Elforsk and EBL Kompetanse and other financing institutions and industries. A Finnish business Merinova, is to be appointed to the project leadership

  20. Preliminary study on hydrogeology in tectonically active areas.

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, Thomas Stephen; Lappin, Allen R.; Gettemy, Glen L.; Jensen, Richard Pearson; Arnold, Bill Walter; James, Scott Carlton; Lee, Moo Yul; Meier, Diane A.

    2006-09-01

    This report represents the final product of a background literature review conducted for the Nuclear Waste Management Organization of Japan (NUMO) by Sandia National Laboratories, Albuquerque, New Mexico, USA. Internationally, research of hydrological and transport processes in the context of high level waste (HLW) repository performance, has been extensive. However, most of these studies have been conducted for sites that are within tectonically stable regions. Therefore, in support of NUMO's goal of selecting a site for a HLW repository, this literature review has been conducted to assess the applicability of the output from some of these studies to the geological environment in Japan. Specifically, this review consists of two main tasks. The first was to review the major documents of the main HLW repository programs around the world to identify the most important hydrologic and transport parameters and processes relevant in each of these programs. The review was to assess the relative importance of processes and measured parameters to site characterization by interpretation of existing sensitivity analyses and expert judgment in these documents. The second task was to convene a workshop to discuss the findings of Task 1 and to prioritize hydrologic and transport parameters in the context of the geology of Japan. This report details the results and conclusions of both of these Tasks.

  1. Preliminary study on solar-assisted tobacco curing in Thailand

    Energy Technology Data Exchange (ETDEWEB)

    Bamrungwong, S [Chiang Mai Univ.; Suchinda, B; Malila, D

    1982-04-01

    A solar heating system for assisting flue curing of Virginia tobacco leaf was studied. The equipment consisted of a brick and mortar tobacco curing barn of 3.6 m/sup 3/ volume. The solar air heater of 2.8 m/sup 2/ was a non-focus type, made from corrugated galvanized stel sheet coated with flat-black paint. The collector had a single glass cover on top and a 25 mm layer of styrofoam at the bottom. Electrical heating was utilized inside the bar to simulate the main heat source. The system under study had no thermal storage, therefore it was extremely difficult to regulate the temperature inside the barn precisely. Consequently, the solar assisting mode is not recommended during the yellowing stage of curing where very precise temperature control is required. Utilization of solar energy during other stages of curing showed a saving of the main conventional energy up to 33 to 15 percent. The average thermal efficiencies of the collector varied from 70 percent at high flow rate to 67 percent at low flow rate. 6 references.

  2. Biogas production from pineapple core - A preliminary study

    Science.gov (United States)

    Jehan, O. S.; Sanusi, S. N. A.; Sukor, M. Z.; Noraini, M.; Buddin, M. M. H. S.; Hamid, K. H. K.

    2017-09-01

    Anaerobic digestion of pineapple waste was investigated by using pineapple core as the sole substrate. Pineapple core was chosen due to its high total sugar content thus, indicating high amount of fermentable sugar. As digestion process requires the involvement of microorganisms, wastewater from the same industry was added in the current study at ratio of 1:1 by weight. Two different sources of wastewater (Point 1 and Point 2) were used in this study to distinguish the performance of microorganism consortia in both samples. The experiment was conducted by using a lab scale batch anaerobic digester made up from 5L container with separate gas collecting system. The biogas produced was collected by using water displacement method. The experiment was conducted for 30 days and the biogas produced was collected and its volume was recorded at 3 days interval. Based on the data available, wastewater from the first point recorded higher volume of biogas with the total accumulated biogas volume is 216.1 mL. Meanwhile, wastewater sample from Point 2 produced a total of 140.5 mL of biogas, by volume. The data shows that the origin and type of microorganism undeniably play significant role in biogas production. In fact, other factors; pH of wastewater and temperature were also known to affect biogas production. The anaerobic digestion is seen as the promising and sustainable alternatives to current disposal method.

  3. Preliminary studies of Brazilian wood using different radioisotopic sources

    International Nuclear Information System (INIS)

    Carvalho, Gilberto; Silva, Leonardo Gondim de Andrade e

    2013-01-01

    Due to availability and particular features, wood was one of the first materials used by mankind with a wide variety of applications. It can be used as raw material for paper and cellulose manufacturing; in industries such as chemical, naval, furniture, sports goods, toys, and musical instrument; in building construction and in the distribution of electric energy. Wood has been widely researched; therefore, wood researchers know that several aspects such as temperature, latitude, longitude, altitude, sunlight, soil, and rainfall index interfere with the growth of trees. This behavior explains why average physical-chemical properties are important when wood is studied. The majority of researchers consider density to be the most important wood property because of its straight relationship with the physical and mechanical properties of wood. There are three types of wood density: basic, apparent and green. The apparent density was used here at 12% of moisture content. In this study, four different types of wood were used: 'freijo', 'jequetiba', 'muiracatiara' and 'ipe'. For wood density determination by non-conventional method, Am-241, Ba-133 and Cs-137 radioisotopic sources; a NaI scintillation detector and a counter were used. The results demonstrated this technique to be quick and accurate. By considering the nuclear parameters obtained as half value layers and linear absorption coefficients, Cs-137 radioisotopic source demonstrated to be the best option to be used for inspection of the physical integrity of electric wooden poles and live trees for future works. (author)

  4. Preliminary study of interventional treatment for tubal pregnancy

    International Nuclear Information System (INIS)

    Tang Yukuan; Chen Hanwei; Li Kaifang; Jiang Zaibo; Ma Zhuang; Liu Huanling

    2000-01-01

    Objective: To study the clinical value and methods of interventional treatment for tubal pregnancy. Methods: Two different methods were used in the interventional treatment of 18 patients with tubal pregnancy, which were transvaginal tubal intra-gestational methotrexate (MTX) injection and intra-utero-arterial MTX infusion. The former was selected for the treatment of 8 patients and the latter for 10 patients. Cook-fallopian tube catheterization set and the general angiographic catheters of 4.1 Fr Cobra were used. After the treatment, conditions of the patients, β-HCG level and ultrasound changes of the pregnant bladder were the main indexes for monitoring the therapeutic effect in this study. Results: The successful rate, cure rate, embryo killing rate reached 100%, 88.9%(16/18) and 94.4% (17/18) respectively. Two cases of intra-utero-arterial MTX infusion treatment failed, β-HCG was reduced to normal level with an average of 11.2 +- 11.6 d (3-28 d). In 10 cases, the ultrasound showed that the pregnancy bladder disappeared in 2-3 weeks, accounting for 76.9% (10/13). The longest time was 60 days. The range of menstruation recovery was 37 +- 9 d (21-50 d). Conclusions: Interventional treatment of tubal pregnancy is effective, reliable and easy for operation. It will be especially effective by arterial procedure. Interventional treatment will be a important method for terminating tubal pregnancy

  5. Septin 7 immunoexpression in papillary thyroid carcinoma: a preliminary study.

    Science.gov (United States)

    Igci, Yusuf Ziya; Erkilic, Suna; Arslan, Ahmet

    2014-07-01

    Papillary thyroid carcinoma (PTC) is the most common type among thyroid cancers. The diagnosis of PTC may be challenging when follicular variant (FVPTC) of this disease is present due to the resemblance of nuclear properties of the classical type (CVPTC). However, making use of ancillary molecular markers in the diagnosis of PTC may help. In our study, we aimed to evaluate the SEPT7 protein expression in PTC. A total of 55 paraffin block tissue samples comprising encapsulated FVPTC (FVPTC(e), n=25), and CVPTC (n=15), and benign hyperfunctioning thyroid nodules (HypN, n=15) were used in this study. Nuclear, cytoplasmic, and overall (total) SEPT7 protein expression levels were determined by using immunohistochemistry. Nuclear, cytoplasmic, and overall SEPT7 expressions (p=0.02, p=0.001, p=0.002, respectively) were significantly lower in FVPTC(e) tissues when compared to HypN. In CVPTC group, nuclear expression was significantly lower (p=0.004) while overall and cytoplasmic expressions were not changed (p>0.05). In HypN group, highest nuclear (mean=2.73), cytoplasmic (mean=2.86), and overall (mean=2.86) expression scores were detected. Significantly lower SEPT7 expression in all expressional categories in FVPTC(e) group may be a sign of different molecular signature in this type of tissue. Copyright © 2014 Elsevier GmbH. All rights reserved.

  6. [Psychopathology in online pathological gamblers: a preliminary study].

    Science.gov (United States)

    Barrault, S; Varescon, I

    2012-04-01

    The rapidly expanding gambling offline and online have resulted in an increasing number of gamblers and the problem is likely to get worse in the future. However, online pathological gambling is a not well known. This rapidly developing modality of gambling, which requires to be studied, notably in its links with regular pathological gambling and Internet addiction. Depression and personality disorders are known to be often associated with pathological gambling. Personality disorders have an influence on pathological gambling, increasing its severity. Online gamblers seem to have a particular personality profile, compared to offline gamblers, and could present different personality disorders. Depression is a common comorbidity among online gamblers, as well as offline gamblers. Both types of gamblers have personality disorders, but the nature of these disorders differs: prevalency of personality disorders of cluster B (dramatic, emotional or erratic disorders) is more important in offline gamblers, whereas cluster C (anxious or fearful disorders) is more present in online pathological gamblers. In France, few studies have specifically examined this subject. The objective of the study is to evaluate scores on depression, personality disorders and internet addiction in online pathological gamblers. The South Oaks Gambling Screen (SOGS) is used to assess pathological gambling, Beck's Depression Inventory (BDI) to measure depression, the Personality Disorders Questionnaire (PDQ 4) to assess personality disorders and the Internet Addiction Test (IAT) to assess internet addiction. Participants completed the self-report scales. Questionnaires were strictly confidential. The participants were recruited in gambling places (cafés) and Internet forums. Two groups of pathological gamblers were formed: online gamblers (N=15) and offline gamblers (N=15). Participants gave their informed consent. Participation was voluntary and anonymous and no payment was made. ANALYSIS OF THE

  7. The mechanism of anemia in 4 patients with Hodgkin's disease: a study simultaneously using radioiron and radiochromium

    International Nuclear Information System (INIS)

    Ditu Mpandamadi

    1981-01-01

    To investigate the mechanism of anemias during the course of Hodgkin's disease, a study utilizing blood labeled simultaneously with radioiron (Fe 59 ) and radiochromium (Cr 51 ) was undertaken in 4 patients: 1 male and 3 females 18, 18, 29, 33 years old. The results obtained in this study were compared with those of the relevant literature. It is concluded that the mechanism of anemias, in patients suffering from Hodgkin's disease, combines and increased rate of red cell destruction with abnormalities of iron metabolism. This investigation shows the interest of evaluating the pathogenesis of anemias with an isotope technique simultaneously utilizing Fe 59 and Cr 51

  8. Cognitive processes in criminal profile construction: a preliminary study.

    Science.gov (United States)

    Kocsis, Richard N; Middledorp, Jenny; Try, Andrew C

    2005-12-01

    This study undertook an empirically based examination of the cognitive processes associated with the accurate construction of a criminal psychological profile. This was accomplished by comparing the abilities of profilers and nonprofilers in two simulated profiling exercises that measured both profile accuracy and an individual's performance on various tests of memory and comprehension related to the case materials presented in each exercise. The results of these experiments suggest that an incremental relationship exists between comprehension of the case materials and accuracy of the profiles generated. In addition, the findings provide some tentative indications that the comprehension of case material in a narrative (i.e., written) format is an integral cognitive function to proficient profiling.

  9. The preliminary study on peculiar flavor from irradiated dried duck

    International Nuclear Information System (INIS)

    Li Zongju; Chen Zongdao; Xu Denyi

    1992-01-01

    Peculiar flavor may be induced from irradiative preservation of meat with higher dose. The study on the irradiation of dried duck indicated that peculiar flavor is produced by a threshold of 1.5 kGy and intensifies with the increase of dose. The flavor primarily comes from muscle of dried duck especially from its water soluble protein. With the increase of dose, volatile carbonyl compounds, amines and sulfur compounds increased significantly. Paper chromatography analysis shows that two new volatile carbonyl compounds (R f =0.23 and 0.28) and a new volatile amine-propamine are induced by irradiation. This compounds may be the source of peculiar flavor in irradiated dried duck

  10. The preliminary study on peculiar flavor from irradiated dried duck

    Energy Technology Data Exchange (ETDEWEB)

    Zongju, Li; Zongdao, Chen; Denyi, Xu [Southwest Agricultural Univ., Chongqing, SC (China)

    1992-11-01

    Peculiar flavor may be induced from irradiative preservation of meat with higher dose. The study on the irradiation of dried duck indicated that peculiar flavor is produced by a threshold of 1.5 kGy and intensifies with the increase of dose. The flavor primarily comes from muscle of dried duck especially from its water soluble protein. With the increase of dose, volatile carbonyl compounds, amines and sulfur compounds increased significantly. Paper chromatography analysis shows that two new volatile carbonyl compounds (R[sub f] =0.23 and 0.28) and a new volatile amine-propamine are induced by irradiation. This compounds may be the source of peculiar flavor in irradiated dried duck.

  11. Radial electrical field effects in TJ-II. (Preliminary study)

    International Nuclear Information System (INIS)

    Guasp, J.

    1996-01-01

    The influence of the radial electric field upon the neoclassical transport coefficients of TJ-II helical axis Stellarator has been calculated as well on the microwave heating stage (ECRH) as on the neutral injection one (NBI). The influence of the solutions for the self-consistent ambipolar field on confinement times and temperatures has been studied by means of a zero-dimensional energy balance. The simultaneous presence of two roots, the electronic and the ionic one, is observed for the ECRH phase, while for NBI only the ionic root appears, although with a strong field intensity that could produce a favourable effect on confinement. The interest and need of the extension of these calculations to include radial profile effects by using spatial dependent transport codes in stressed

  12. Portuguese Version of Teacher Feedback Scale: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Márcia Laranjeira

    2018-06-01

    Full Text Available Abstract Teacher feedback in the classroom has a powerful influence on pupils’ performance and motivation. The study aims to analyze psychometric properties of the Portuguese version of the Teacher Feedback Scale (TFS in a sample of 228 children in the 4th grade of schooling. Exploratory factor analysis shows similarities with the original version, and the differences observed were based on the children’s cognitive development characteristics and cultural specificities of the two samples. The relationship between teacher feedback and students’ motivational variables was confirmed, such as the preference that the children expressed for the school subjects. The possibility to make some changes in the items is contemplated, in order to increase validity and reliability of the measure. The data highlight the potential of using the TFS in schools, which could contribute towards clarifying the teachers’ role in the formation of pupils’ self-concept.

  13. Low density lipoprotein receptors: preliminary results on 'in vivo' study

    International Nuclear Information System (INIS)

    Lupattelli, G.; Virgolini, I.; Li, S.R.; Sinzinger, H.

    1991-01-01

    Plasmatic levels of low density lipoproteins (LDL) are regulated by the receptor pathway and most LDL receptor are located in the liver. A receptor defect due to genetic mutations of the LDL receptor gene is the cause of familial hypercholesterolemia (F.H.), a disease characterized by high cholesterol levels and premature atherosclerosis. Injections of autologous radiolabelled LDL, followed by hepatic scintiscanning, can be used to obtain 'in vivo' quantification of hepatic receptor activity, both in normal and hypercholesterolemic patients. In this study we observe no hepatic increase of radioactivity in patients affected by F.H., confirming the liver receptor defect. Scintigraphy is a non-invasive technique which can be used to diagnose this disease and to monitor the efficiacy of hypolipidemic therapy. (Authors)

  14. Sleep, sleepiness and school start times: a preliminary study.

    Science.gov (United States)

    Dexter, Donn; Bijwadia, Jagdeep; Schilling, Dana; Applebaugh, Gwendolyn

    2003-01-01

    High school students are reported to be excessively sleepy, resulting in decreased academic performance, increased psycho-social problems and increased risk of morbidity and mortality from accidents. Early school start times have been noted to contribute to this problem. This report attempts to confirm the relationship of early school start times with decreased sleep and increased sleepiness. We examined sophomore and junior students in 2 local high schools with different start times and measured the amount of time slept and sleepiness. We found that students at the early start school reported reduced sleep time and more sleepiness than their counterparts at the later starting school. Early school start times are associated with student reports of less sleep and increased sleepiness. Further studies in larger groups are recommended in view of the potential significant impact of sleep deprivation in this age group.

  15. Clinical and imaging characteristics of the vascular dementia. Preliminary studies

    International Nuclear Information System (INIS)

    Gomez Viera, Nelson; Rivero Arias, Edmundo; Perez Nellar, Jesus; Begueria Santos, Ramon; Arias Sifontes, William; Raiteris Flores, Juan

    1997-01-01

    A descriptive prospective study was carried out in 41 patients presenting with vascular dementia from Habana Vieja municipality, Havana City, in order to know some of the clinical and imaging characteristics of this disease. The main risk factors observed were the history of cerebrovascular disease and arterial hypertension. Depression, sleeping disorders and focal and pseudo bulbar neurologic signs were the most frequent clinical findings. Folstein neuropsychological test evidenced an important disorder of attention, calculation, the evocation memory and orientation. According to this test, 29 % of the patients had a severe dementia and nearly 50 % showed a severe handicap. The most frequent imaging findings observed in the computerized axial tomography of the cranium were cerebral atrophy, and single or multiple infarctions. Multiple cerebral infarctions, the lacunar status, subcortical encephalopathy of Binswanger, and single infarction located in cerebral areas related to cognition were considered as possible psychopathological mechanisms associated with the disease

  16. Preliminary Design Study for a National Digital Seismograph Network

    Science.gov (United States)

    Peterson, Jon; Hutt, Charles R.

    1981-01-01

    Introduction Recently, the National Research Council published a report by the Panel on National, Regional, and Local Seismograph Networks of the Committee on Seismology in which the principal recommendation was for the establishment of a national digital seismograph network (NDSN). The Panel Report (Bolt, 1980) addresses both the need and the scientific requirements for the new national network. The purpose of this study has been to translate the scientific requirements into an instrumentation concept for the NSDS. There are literally hundreds, perhaps thousands, of seismographs in operation within the United States. Each serves an important purpose, but most have limited objectives in time, in region, or in the types of data that are being recorded. The concept of a national network, funded and operated by the Federal Government, is based on broader objectives that include continuity of time, uniform coverage, standardization of data format and instruments, and widespread use of the data for a variety of research purposes. A national digital seismograph network will be an important data resource for many years to come; hence, its design is likely to be of interest to most seismologists. Seismologists have traditionally been involved in the development and field operation of seismic systems and thus have been familiar with both the potential value and the limitations of the data. However, in recent years of increasing technological sophistication, the development of data sstems has fallen more to system engineers, and this trend is likely to continue. One danger in this is that the engineers may misinterpret scientific objectives or subordinate them to purely technological considerations. Another risk is that the data users may misuse or misinterpret the data because they are not aware of the limitations of the data system. Perhaps the most important purpose of a design study such as this is to stimulate a dialogue between system engineers and potential data users

  17. A preliminary study of landslide gouge dating by TL technique

    Energy Technology Data Exchange (ETDEWEB)

    Fengju, Ji; Jianping, Li [Inst. of Geology, National Seismological Bereau, Beijing (China); Mingda, Liu [Inst. of Crustal Dynamics, SSB, Beijing (China)

    1993-04-01

    The key to date slipping of landslide by TL method is whether the temperature and pressure caused by slipping can lead the original TL to 'zero'for some minerals within the slipping band. For this purpose, the simulated experiments under different temperature-pressure were made and the TL annealing effect of landslide gouge was studied. The results show that the frictional heating caused during slipping is a main factor leading the mineral's TL to decrease on the slip plane and that increment of temperature is in close relation with strength of shear stress, thickness of landslide gouge and amount of displacement. As an example, the slipping age of a paleo-landslide at Huangtupo, Hubei Province, has been dated to be about 140 ka.

  18. [Effectiveness of magnetotherapy in optic nerve atrophy. A preliminary study].

    Science.gov (United States)

    Zobina, L V; Orlovskaia, L S; Sokov, S L; Sabaeva, G F; Kondé, L A; Iakovlev, A A

    1990-01-01

    Magnetotherapy effects on visual functions (vision acuity and field), on retinal bioelectric activity, on conductive vision system, and on intraocular circulation were studied in 88 patients (160 eyes) with optic nerve atrophy. A Soviet Polyus-1 low-frequency magnetotherapy apparatus was employed with magnetic induction of about 10 mT, exposure 7-10 min, 10-15 sessions per course. Vision acuity of patients with its low (below 0.04 diopters) values improved in 50 percent of cases. The number of patients with vision acuity of 0.2 diopters has increased from 46 before treatment to 75. Magnetotherapy improved ocular hemodynamics in patients with optic nerve atrophy, it reduced the time of stimulation conduction along the vision routes and stimulated the retinal ganglia cells. The maximal effect was achieved after 10 magnetotherapy sessions. A repeated course carried out in 6-8 months promoted a stabilization of the process.

  19. Preliminary study of chemical compositional data from Amazon ceramics

    International Nuclear Information System (INIS)

    Toyota, Rosimeiri G.; Munita, Casimiro S.; Luz, Fabio A.; Neves, Eduardo G.; Oliveira, Paulo M.S.

    2005-01-01

    Eighty seven ceramic samples from Acutuba, Lago Grande and Osvaldo archaeological sites located in the confluence of the rivers Negro and Solimoes were submitted to chemical analysis using instrumental neutron activation analysis to determine As, Ba, Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Rb, Na, Nd, Sb, Sc, Sm, Ta, Tb, Th, Yb, Zn, and U. The database were studied using the Mahalanobis distance, and discriminant analysis. The results showed that the ceramics of each site differ from each other in chemical composition and that they form three different groups. Chemical classification of the ceramics suggests that vessels were made locally, as only ceramics from the same area show homogeneity of data. (author)

  20. Preliminary study of the uranium favorability of Malheur County, Oregon

    International Nuclear Information System (INIS)

    Erikson, E.H.

    1977-11-01

    A reconnaissance study of middle and upper Tertiary volcaniclastic sedimentary and silicic volcanic rocks in Malheur County, Oregon, indicates that, based upon the data available: (1) it is unlikely that sandstone-type uranium deposits exist in sedimentary rocks of north-central Malheur County; and (2) favorable uranium environments are more likely to exist in and adjacent to uraniferous silicic eruptive centers and plugs. Some rhyolites in the northern part of the county contain marginally anomalous uranium abundances (6 to 8 +- 2 ppM U 3 O 8 ), compared with similar rocks in southeastern Oregon. Available uranium from these rocks, as determined by nitric-acid leaching, approaches 50 to 75 percent of the total chemical U 3 O 8 present. One Pliocene rhyolite vitrophyre sample from Duck Butte in western Malheur County contains 9 +- 2 ppM U 3 O 8 . The uranium contents of these rhyolites approach those found in silicic plugs spatially related to uranium deposits in the Lakeview district, Oregon (Erikson and Curry, 1977). It is possible that undiscovered epithermal and (or) supergene uranium deposits may exist in favorable wall rocks subjacent to uraniferous silicic eruptive centers (Duck Butte), calderas (McDermitt caldera to the south and others identified in western Owyhee County, Idaho), and silicic plugs (as in the Lakeview district). With the exception of one small uranium anomaly found in unconsolidated sands in the Grassy Mountain Formation, the sedimentary rocks observed in the study area did not possess abnormal radioactivity or exhibit evidence of uranium mobility and enrichment. Carbonaceous trash is uncommon in these rocks. Gently dipping sandstone members of the Deer Butte Formation (upper Miocene) and local channel sands in the Grassy Mountain Formation (Pliocene) may have once been the most permeable rocks in the Tertiary section; but, there is no evidence to suggest that they were conduits for uranium-bearing solutions

  1. Hydrothermal reactions of nuclear waste solids . A preliminary study

    International Nuclear Information System (INIS)

    Westsik, J.H. Jr.; Turcotte, R.P.

    1978-09-01

    A simulated high-level waste glass, Supercalcine, and some common ceramic and metallic solids were exposed to hydrothermal conditions at 250 and 350 0 C for time periods ranging from three days to three weeks. Most of the experiments were done in salt brine, but the glass study did include deionized water tests so that the influence of salt could be better understood. Under the extreme hydrothermal conditions of these tests, all of the materials examined underwent measurable changes. The glass is converted to a mixture of crystalline phases, depending upon conditions, giving NaFeSi 2 O 6 as the primary alteration product. The rate of alteration is higher in deionized water than in salt brine; however, under equivalent test conditions, 66% of the Cs originally in the glass is released to the salt brine, while only 6% is released to deionized water. Rb and Mo are the only other fission product elements significantly leached from the glass. Evidence is presented which shows that sintered Supercalcine undergoes chemical changes in salt brine that are qualitatively similar to those experienced by glass samples. High concentrations of Cs enter the aqueous phase, and Sn and Mo are mobilized. Scouting tests were made with a variety of materials including commercial glasses, granite, UO 2 , Al 2 O 3 , steel, and waste glasses. Weight losses under hydrothermal conditions are in a relatively narrow band, with glass and ceramic materials showing 3 to 20 times greater weight losses than 304L stainless steel in the 250 0 C test used. The conclusion from these studies is that virtually all solid materials show hydrothermal reactivity at temperatures between 250 and 350 0 C, and that these extreme conditions are not desirable

  2. Preliminary studies of Brazilian wood using different radioisotopic sources

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Gilberto; Silva, Leonardo Gondim de Andrade e, E-mail: gcarval@ipen.br, E-mail: ftgasilva@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Due to availability and particular features, wood was one of the first materials used by mankind with a wide variety of applications. It can be used as raw material for paper and cellulose manufacturing; in industries such as chemical, naval, furniture, sports goods, toys, and musical instrument; in building construction and in the distribution of electric energy. Wood has been widely researched; therefore, wood researchers know that several aspects such as temperature, latitude, longitude, altitude, sunlight, soil, and rainfall index interfere with the growth of trees. This behavior explains why average physical-chemical properties are important when wood is studied. The majority of researchers consider density to be the most important wood property because of its straight relationship with the physical and mechanical properties of wood. There are three types of wood density: basic, apparent and green. The apparent density was used here at 12% of moisture content. In this study, four different types of wood were used: 'freijo', 'jequetiba', 'muiracatiara' and 'ipe'. For wood density determination by non-conventional method, Am-241, Ba-133 and Cs-137 radioisotopic sources; a NaI scintillation detector and a counter were used. The results demonstrated this technique to be quick and accurate. By considering the nuclear parameters obtained as half value layers and linear absorption coefficients, Cs-137 radioisotopic source demonstrated to be the best option to be used for inspection of the physical integrity of electric wooden poles and live trees for future works. (author)

  3. Wind energy in electric power production. Preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Lento, R; Peltola, E

    1984-01-15

    The wind speed conditions in Finland have been studied with the aid of the existing statistics of the Finnish Meteorological Institute. With the aid of the statistics also estimates on the available wind energy were made. 800 wind power plants, 1.5 MW each, on the windiest west coast would produce about 2 TWh energy per year. Far more information on the temporal, geographical and vertical distribution of the wind speed than the present statistics include is needed when the available wind energy is estimated, when wind power plants are dimensioned optimally, and when suitable locations are chosen for them. The investment costs of a wind power plant increase when the height of the tower or the diameter of the rotor is increased, but the energy production increases, too. Thus, overdimensioning the wind power plant in view of energy needs or the wind conditions causes extra costs. The cost of energy produced by wind power can not yet compete with conventional energy, but the situation changes to the advantage of wind energy, if the real price of the plants decreases (among other things due to large series production and increasing experience), or if the real price of fuels rises. The inconvinience on the environment caused by the wind power plants is considered insignificant. The noise caused by the plant attenuates rapidly with distance. No harmful effects birds and other animals caused by the wind power plants have been observed in the studies made abroad. Parts of a plant getting loose during an accident, or ice forming on the blades are estimated to fly even from a large plant only a few hundred meters.

  4. [The aggression in SPDC: an observational study. Preliminary data].

    Science.gov (United States)

    Minutolo, Giuseppe; Cannavò, Dario; Petralia, Antonino; Gandolfo, Liliana; Palermo, Filippo; Aguglia, Eugenio

    2010-01-01

    In the different psychiatric disorders the aggression often leads to uncontrolled events, taking aspects of impulsiveness and irrationality. Our research proposes the assessment of socio-demographic and clinical characteristics of patients with a psychiatric disorder, who presented an aggressive event. The observational study was conducted on a sample of 50 patients (34 men and 16 women), hospitalized following the manifestation of an aggressive event. For each patient was provided an assessment of socio-demographic and clinical variables and a psychometric investigation through: the OAS, for the analysis of aggressive episodes; the BDHI, for the hostile behavior and attitudes; the BIS-11, for the impulsiveness and the BPRS for the psychopathological aspects. Among the socio-demographic features investigated, the highest correlation with aggressive behavior was related to the concomitant substance abuse, type of admission to psychiatric hospital and the male gender. The OAS has shown a greater propensity to directed-aggression in males with schizophrenia, and self-directed in females with major depression. The BPRS has shown a positive correlation between hetero-directed aggressive behavior and positive symptomatology, and between the self-directed and depression, risk of suicide, feelings of guilt and somatic concerns. The BDHI has indicated greater suspicion in women's group. The hypothesis that aggression is otherwise related to specific socio-demographic and clinical characteristics was confirmed by our study. The data suggest that early identification and assessment of potential risk factors involved in the genesis of aggressive episodes would allow the clinician to implement a better strategy for prevention and intervention.

  5. Self-acceptance of stuttering: A preliminary study.

    Science.gov (United States)

    De Nardo, Thales; Gabel, Rodney M; Tetnowski, John A; Swartz, Eric R

    2016-01-01

    This study explored the relationship between self-acceptance of stuttering and (1) psychosocial factors (self-esteem, hostility towards others, emotional support, and perceived discrimination); (2) treatment history (support group participation, therapy duration, and perceived therapy success); and (3) previously reported variables in self-acceptance of stuttering, which include age and stuttering severity. Participants were 80 adults who stutter who were recruited with assistance from the National Stuttering Association and Board Certified Specialists in Fluency Disorders. Participants completed an electronic survey composed of an acceptance of stuttering scale, psychosocial scales, and a participant information questionnaire. Statistical analysis identified significant correlations between participants' reports of self-acceptance of stuttering and self-esteem, perceived discrimination, hostility towards others, and perceived therapy outcome. Self-esteem was positively correlated with self-acceptance, while hostility towards others and perceived discrimination was negatively correlated with self-acceptance. Participants who perceived their therapy outcome to be successful were significantly more likely to report higher levels of self-acceptance. No significant relationships were found between self-acceptance of stuttering and support group participation, emotional support, stuttering severity, and participant age. This exploratory investigation has provided a foundation for future studies on the self-acceptance of stuttering. The findings indicate common psychosocial variables in self-acceptance of stuttering and of other disabilities. The significant relationships between self-acceptance of stuttering and psychosocial and therapeutic variables found need to be further explored to identify its causalities and clinical implications. The reader will be able to (1) discuss the importance of assessing self-acceptance of stuttering, (2) summarize the literature on self

  6. Preliminary Hydrogeologic Characterization Results from the Wallula Basalt Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    B.P. McGrail; E. C. Sullivan; F. A. Spane; D. H. Bacon; G. Hund; P. D. Thorne; C. J. Thompson; S. P. Reidel; F. S. Colwell

    2009-12-01

    The DOE's Big Sky Regional Carbon Sequestration Partnership has completed drilling the first continental flood basalt sequestration pilot borehole to a total depth (TD) of 4,110 feet on the Boise White Paper Mill property at Wallula, Washington. Site suitability was assessed prior to drilling by the 2007-2008 acquisition, processing and analysis of a four-mile, five-line three component seismic swath, which was processed as a single data-dense line. Analysis of the seismic survey data indicated a composite basalt formation thickness of {approx}8,000 feet and absence of major geologic structures (i.e., faults) along the line imaged by the seismic swath. Drilling of Wallula pilot borehole was initiated on January 13, 2009 and reached TD on April 6, 2009. Based on characterization results obtained during drilling, three basalt breccia zones were identified between the depth interval of 2,716 and 2,910 feet, as being suitable injection reservoir for a subsequent CO2 injection pilot study. The targeted injection reservoir lies stratigraphically below the massive Umtanum Member of the Grande Ronde Basalt, whose flow-interior section possesses regionally recognized low-permeability characteristics. The identified composite injection zone reservoir provides a unique and attractive opportunity to scientifically study the reservoir behavior of three inter-connected reservoir intervals below primary and secondary caprock confining zones. Drill cuttings, wireline geophysical logs, and 31one-inch diameter rotary sidewall cores provided geologic data for characterization of rock properties. XRF analyses of selected rock samples provided geochemical characterizations of the rocks and stratigraphic control for the basalt flows encountered by the Wallula pilot borehole. Based on the geochemical results, the pilot borehole was terminated in the Wapshilla Ridge 1 flow of the Grande Ronde Basalt Formation. Detailed hydrologic test characterizations of 12 basalt interflow

  7. Preliminary Study of Potential Market for Small Reactors

    International Nuclear Information System (INIS)

    Minato, A.; Brown, N. W.

    2008-01-01

    Small reactors are an energy supply for a specific purpose and oriented for a different market than large reactors. Small reactors will provide a local solution for developed and developing countries, such as, in remote areas, on small grids, or for non-electricity applications such as, district heating, seawater desalination and process heat. Single or medium sized power stations with small reactors should be compared with single fissile or renewable energy source and not be compared with large reactors. CRIEPI and LLNL have studied the business opportunities for small reactors. The small reactor concept is planned for initial use in small remote communities and in developing countries with small power distribution grid. Rapid installation and simple operation of the small plants is intended to support use in these communities without requiring development of a substantial nuclear technology infrastructure. In this study, two approaches were used in the assessment of the potential market. The first approach took a global look at the need for small nuclear plants. Then selected countries and sites were identified based on countries expressing interest in small reactors to the IAEA and consideration of sites in the US and Japan. (1) Tunisia, Mexico, Indonesia, Uruguay, Egypt and Argentina have demonstrated interest in nuclear power. Selecting one of these is dependent on political and socioeconomic factors, some of which have been identified, that require direct interaction with the countries to establish if they represent real opportunities. (2) The states of Hawaii and Alaska in the United States have high power cost and remote or island communities that may benefit from small nuclear plants. Alaska has shown greater interest in power alternatives including small than Hawaii and there is clearly less public resistance to nuclear power in Alaska. (3) The countries in Central America are actively expanding their power grids but have not demonstrated great interest

  8. Episodic and Binge Gambling: An Exploration and Preliminary Quantitative Study.

    Science.gov (United States)

    Cowlishaw, S; Nespoli, E; Jebadurai, J K; Smith, N; Bowden-Jones, H

    2018-03-01

    The DSM-5 includes provisions for episodic forms of gambling disorder, with such changes aligned with earlier accounts of potential binge gambling behaviours. However, there is little research that indicates the utility of these classifications of episodic or binge gambling, and this study considered their characteristics in a clinical sample. It involved administration of a new binge gambling screening tool, along with routine measures, to n = 214 patients entering a specialist treatment clinic for gambling problems. Results indicated that episodic gambling was common in this clinical context, with 28 and 32% of patients reporting gambling episodes that were (a) regular and alternating, and (b) irregular and intermittent, respectively. These patterns were distinguished by factors including associations with covariates that indicated differences from continuous gamblers. For example, the irregular episodic gamblers, but not the regular pattern, demonstrated lower levels of problem gambling severity and comorbidity. Rates of potential binge gambling, which was defined in terms of additional criteria, were around 4% and numbers were insufficient for comparable analyses. The findings support inclusion of episodic forms of gambling disorder in the DSM-5, but highlight the need for improved recognition and research on heterogeneous forms of episodic gambling.

  9. Preliminary study of visual effect of multiplex hologram

    Science.gov (United States)

    Fu, Huaiping; Xiong, Bingheng; Yang, Hong; Zhang, Xueguo

    2004-06-01

    The process of any movement of real object can be recorded and displayed by a multiplex holographic stereogram. An embossing multiplex holographic stereogram and a multiplex rainbow holographic stereogram have been made by us, the multiplex rainbow holographic stereogram reconstructs the dynamic 2D line drawing of speech organs, the embossing multiplex holographic stereogram reconstructs the process of an old man drinking water. In this paper, we studied the visual result of an embossing multiplex holographic stereogram made with 80 films of 2-D pictures. Forty-eight persons of aged from 13 to 67 were asked to see the hologram and then to answer some questions about the feeling of viewing. The results indicate that this kind of holograms could be accepted by human visual sense organ without any problem. This paper also discusses visual effect of the multiplex holography stereograms base on visual perceptual psychology. It is open out that the planar multiplex holograms can be recorded and present the movement of real animal and object. Not only have the human visual perceptual constancy for shape, just as that size, color, etc... but also have visual perceptual constancy for binocular parallax.

  10. A preliminary study of DTI Fingerprinting on stroke analysis.

    Science.gov (United States)

    Ma, Heather T; Ye, Chenfei; Wu, Jun; Yang, Pengfei; Chen, Xuhui; Yang, Zhengyi; Ma, Jingbo

    2014-01-01

    DTI (Diffusion Tensor Imaging) is a well-known MRI (Magnetic Resonance Imaging) technique which provides useful structural information about human brain. However, the quantitative measurement to physiological variation of subtypes of ischemic stroke is not available. An automatically quantitative method for DTI analysis will enhance the DTI application in clinics. In this study, we proposed a DTI Fingerprinting technology to quantitatively analyze white matter tissue, which was applied in stroke classification. The TBSS (Tract Based Spatial Statistics) method was employed to generate mask automatically. To evaluate the clustering performance of the automatic method, lesion ROI (Region of Interest) is manually drawn on the DWI images as a reference. The results from the DTI Fingerprinting were compared with those obtained from the reference ROIs. It indicates that the DTI Fingerprinting could identify different states of ischemic stroke and has promising potential to provide a more comprehensive measure of the DTI data. Further development should be carried out to improve DTI Fingerprinting technology in clinics.

  11. Preliminary studies on affirmative action in a brazilian university1

    Directory of Open Access Journals (Sweden)

    Eduardo de São Paulo

    2010-06-01

    Full Text Available As a signatory to Durban III World Conference against Racism, Discrimination, Xenophobia and other forms of Intolerance, Brazil has committed itself to the enforcement of mechanisms to promote social equity. As a consequence, governmental programs have been implemented, aiming at the inclusion of Afrodescendents h students in the academy is minimal and does not relate to what can be observed in the general population. As an example of such endeavor, Universidade de Brasília (UnB has started an Affirmative Action program in order to include a contingent of 20% of its freshman students as representatives of racial underprivileged groups. This policy started in August 2004. The present study aimed to investigate the perceptions of students and general public to this policy. An instrument, based partially on McConahay´s (1986 Modern Racism scale, was administered to a sample of 316 students. A factor analysis (AF extracted five factors, corresponding to 48% of the total variance explained. An Analysis of Variance (Anova was performed to better understand the results, concerning both age and gender of the subjects. Results show that, although students demonstrated interest in the implementing of Affirmative Action programs, and are aware of the relevance of such procedures to the cultural and social structure of the community, they do not agree with their reasons or measures taken, or to the existence of the problem itself.

  12. PRELIMINARY STUDIES OF RIVETED JOINTS AT FEED FORCE

    Directory of Open Access Journals (Sweden)

    Radosław Bielawski

    2015-08-01

    Full Text Available The aim of the study was to determine the feasibility of riveted joints in composites materials. Static tensile test method was used. In the test one type of glass fabric was used (Interglas 92140 from which two types of composite samples were prepared. In each sample the same type of fiber with the same fiber orientation – 3 layers - was used. The samples had dimensions of 100×100 mm and thickness of approximately 1 mm. The composite probes were located in a metal frame with a screw connection which was made of screws with nominal thread pitch M5. Screws were tightened with constant torque. It was to provide an axial force to the sample during the tensile test. The frame was placed between cross-bars of tensile machine INSTRON 8516. The samples were stretched at a speed of 0.05 mm/s at a distance up to 16 mm. During the tensile test displacement of the samples and pull force were registered. Depending on the fibre orientations and the value of feed force, damage models were described. On the basis of the results the possibility of usage of aluminium rivet nuts connections in composite materials was determined.

  13. Pulmonary functions in plastic factory workers: a preliminary study.

    Science.gov (United States)

    Khaliq, Farah; Singh, Pawan; Chandra, Prakash; Gupta, Keshav; Vaney, Neelam

    2011-01-01

    Exposure to long term air pollution in the work environment may result in decreased lung functions and various other health problems. A significant occupational hazard to lung functions is experienced by plastic factory workers. The present study is planned to assess the pulmonary functions of workers in the plastic factory where recycling of pastic material was done. These workers were constantly exposed to fumes of various chemicals throughout the day. Thirty one workers of plastic factory were assessed for their pulmonary functions. Parameters were compared with 31 age and sex matched controls not exposed to the same environment. The pulmonary function tests were done using Sibelmed Datospir 120 B portable spirometer. A significant decrease in most of the flow rates (MEF 25%, MEF 50%, MEF 75% and FEF 25-75%) and most of the lung volumes and capacities (FVC, FEV1, VC, TV, ERV, MVV) were observed in the workers. Smoking and duration of exposure were not affecting the lung functions as the non smokers also showed a similar decrement in pulmonary functions. Similarly the workers working for less than 5 years also had decrement in pulmonary functions indicating that their lungs are being affected even if they have worked for one year. Exposure to the organic dust in the work environment should be controlled by adequate engineering measures, complemented by effective personal respiratory protection.

  14. Social network analysis in identifying influential webloggers: A preliminary study

    Science.gov (United States)

    Hasmuni, Noraini; Sulaiman, Nor Intan Saniah; Zaibidi, Nerda Zura

    2014-12-01

    In recent years, second generation of internet-based services such as weblog has become an effective communication tool to publish information on the Web. Weblogs have unique characteristics that deserve users' attention. Some of webloggers have seen weblogs as appropriate medium to initiate and expand business. These webloggers or also known as direct profit-oriented webloggers (DPOWs) communicate and share knowledge with each other through social interaction. However, survivability is the main issue among DPOW. Frequent communication with influential webloggers is one of the way to keep survive as DPOW. This paper aims to understand the network structure and identify influential webloggers within the network. Proper understanding of the network structure can assist us in knowing how the information is exchanged among members and enhance survivability among DPOW. 30 DPOW were involved in this study. Degree centrality and betweenness centrality measurement in Social Network Analysis (SNA) were used to examine the strength relation and identify influential webloggers within the network. Thus, webloggers with the highest value of these measurements are considered as the most influential webloggers in the network.

  15. Preliminary clinical study on non-transecting anastomotic bulbomembranous urethroplasty.

    Science.gov (United States)

    Le, Wei; Li, Chao; Zhang, Jinfu; Wu, Denglong; Liu, Bo

    2017-06-01

    This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethroplasty. In the other group, 11 patients underwent conventional posterior urethra end-to-end anastomosis. The effect of operation was evaluated using the following parameters: the bleeding amount during operation, operation time, IIEF-5 scores after operation, maximum flow rate (Qmax), and rating scale of quality of life (QoL). The comparison between the conventional posterior urethra end-to-end anastomosis group and the non-transecting anastomotic urethroplasty group showed no significant difference with regard to average operation time. However, a significant difference was observed between the groups with regard to the bleeding amount during operation. The patients in the group of non-transecting anastomotic urethroplasty urinated smoothly after the removal of catheter. Meanwhile, one patient from the group of conventional posterior urethra end-to-end anastomosis had difficulty urinating after the removal of catheter. Furthermore, significant differences in the operation time, bleeding amount during operation, IIEF-5 scores after operation, and rating scale of QoL were observed, whereas no significant difference was observed between urine flow rates of the two groups after operation. Overall, nontransecting anastomotic urethroplasty is effective for posterior urethra reconstruction, and it can reduce the occurrence rate of erectile dysfunction after operation.

  16. Preliminary study of radioactive concentration in treated sewage water

    Energy Technology Data Exchange (ETDEWEB)

    Elassaly, F M; Beal, A D.R. [Ministry of Health P.O. Box 1853 Dubai, (United Arab Emirates)

    1995-10-01

    Water from sewage treatment plant is used after processing for irrigation. Two water samples and one consolidated sludge (waste treatment products) were taken each day for period of months. Medical applications and research are the main sources of radioactivity such as Cr-51, Co-57, Ga-67, Se-75, Tc-99 m, In-111, Au-198 and Tl-201. Measurements were carried out using Hp Ge spectrometer with one liter Marinelli breaker. The maximum detected activity was 5.7 Bq.liter with a daily average of 2.4 Bq/liter for water. In the second period maximum activity was found to be 5 Bq/liter with an average daily activity 1.8 Bq/liter. The maximum activity recorded in the sludge during this period was 352 Bq/liter of which 343 Bq/liter was from I-131. The average daily activity was 162 Bq/liter. From these studies the levels of radioactivity concentration were 5 Bq/liter with an average 2 Bq/1 compared level 10 Bq/1 set for drinking water for Gcc countries. Although the sludge show higher activity of 353 Bq/liter it is kept for about year before being disposed. The maximum level for animal fodder is 300 Bq/kg for Gcc countries. These results indicate that radioactive concentration (2 Bq/liter) in the treated waste water present hazard to the public and environment. 6 figs., 4 tabs.

  17. An automatic tooth preparation technique: A preliminary study

    Science.gov (United States)

    Yuan, Fusong; Wang, Yong; Zhang, Yaopeng; Sun, Yuchun; Wang, Dangxiao; Lyu, Peijun

    2016-04-01

    The aim of this study is to validate the feasibility and accuracy of a new automatic tooth preparation technique in dental healthcare. An automatic tooth preparation robotic device with three-dimensional motion planning software was developed, which controlled an ultra-short pulse laser (USPL) beam (wavelength 1,064 nm, pulse width 15 ps, output power 30 W, and repeat frequency rate 100 kHz) to complete the tooth preparation process. A total of 15 freshly extracted human intact first molars were collected and fixed into a phantom head, and the target preparation shapes of these molars were designed using customised computer-aided design (CAD) software. The accuracy of tooth preparation was evaluated using the Geomagic Studio and Imageware software, and the preparing time of each tooth was recorded. Compared with the target preparation shape, the average shape error of the 15 prepared molars was 0.05-0.17 mm, the preparation depth error of the occlusal surface was approximately 0.097 mm, and the error of the convergence angle was approximately 1.0°. The average preparation time was 17 minutes. These results validated the accuracy and feasibility of the automatic tooth preparation technique.

  18. Left nucleus accumbens atrophy in deficit schizophrenia: A preliminary study.

    Science.gov (United States)

    De Rossi, Pietro; Dacquino, Claudia; Piras, Fabrizio; Caltagirone, Carlo; Spalletta, Gianfranco

    2016-08-30

    A question that remains to be answered is whether schizophrenia can be characterized by a single etiopathophysiology or whether separate sub-syndromes should be differentiated to define specific mechanisms for each sub-type. Individuals affected by the deficit subtype of schizophrenia (DSZ) display avolitional/amotivational features that respond poorly to conventional treatments. Characterizing DSZ from a neuroanatomical point of view may help clarify this issue and develop new treatment strategies. To determine if DSZ is associated with structural alterations in specific deep grey matter structures linked to its key clinical features, 22 DSZ patients, 22 non-deficit schizophrenia (NDSZ) patients and 22 healthy controls (HC) were recruited for a case-control cross-sectional study. High-resolution magnetic resonance imaging was performed in all subjects and volumes of deep grey matter structures were measured using FreeSurfer. DSZ patients displayed smaller left accumbens volumes compared to both NDSZ patients and HC. Moreover, age and duration of illness were significantly associated with lower volume of the left accumbens in DSZ but not in NDSZ. Findings indicate that DSZ is associated with lower volume of the nucleus accumbens in the dominant hemisphere. This is consistent with the psychopathological features and functional impairments present in DSZ and thus indicates a potential mechanism. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Frequency of psychological alterations in primary antiphospholipid syndrome: preliminary study.

    Science.gov (United States)

    Sadetski, M; Tourinho Moretto, M L; Correia de Araujo, R P; de Carvalho, J F

    2018-04-01

    Objectives To detect the frequency of psychological alterations in primary antiphospholipid syndrome patients. Methods Thirty-six primary antiphospholipid syndrome patients were analyzed by a psychological interview using a standard protocol and review of medical charts. Clinical manifestations, associated comorbidities, antiphospholipid antibodies, and treatment were also evaluated. Results The mean age was 44.2 ± 10.8 years, 29 (80%) were women and 29 (80%) were of Caucasian race. The mean duration of disease was 7.3 ± 5.2 years. The frequency of the presence of psychological alterations was 97.1%. Family dependence was observed in 14 (40%), memory loss in 12 (34.3%), social losses in 12 (34.3%), sexual limitations in seven (20%), sadness in six (17.1%), severe speech limitation in four (11.4%), anxiety in three (8.6%), learning difficulty in two (5.7%), generalized phobia in two (5.7%), suicide ideation in one (2.6%), agoraphobia in one (2.6%), and obsessive-compulsive disorder in one (2.6%). Conclusion This study demonstrated that almost all primary antiphospholipid syndrome patients have psychological alterations. These data reinforce the need for psychological evaluation in primary antiphospholipid syndrome patients.

  20. Preliminary study of pseudorandom binary sequence pulsing of ORELA

    International Nuclear Information System (INIS)

    Larson, N.M.; Olsen, D.K.

    1980-03-01

    It has been suggested that pseudorandom binary sequence (PRBS) pulsing might enhance the performance of the Oak Ridge Electron Linear Accelerator (ORELA) for neutron-induced, time-of-flight (TOF) cross-section measurements. In this technical memorandum, equations are developed for expected count rates, statistical variances, and backgrounds for a pulsing scheme in which a PRBS is superimposed on the periodic equalintensity ORELA bursts. Introduction of the PRBS modification permits neutrons of different energies originating from different bursts to reach the detector simultaneously, and the signal corresponding to a unique flight time to be extracted mathematically. Relative advantages and disadvantages of measurements from conventional and PRBS pulsing modes are discussed in terms of counting statistics and backgrounds. Computer models of TOF spectra are generated for both pulsing modes, using as examples a 20-meter 233 U fission-chamber measurement and a 155-meter 238 U sample-in transmission measurement. Detailed comparisons of PRBS vs conventional results are presented. This study indicates that although PRBS pulsing could enhance ORELA performance for selected measurements, for general ORELA operation the disadvantages from PRBS pulsing probably outweigh the advantages

  1. Interviewing German scientists on climate change. A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Ungar, S. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Kuestenforschung; Toronto Univ., Scarborough (Canada)

    2004-07-01

    This study is based on in-depth interviews with 25 German scientists at the Coastal Research Institute of the GKSS-Forschungszentrum. It takes as its context the differential rhetoric and planning on climate change found in Germany and North America. The interviews try to throw light on the early German decision to address climate change, and to assess the current attitudes, beliefs and experiences of these German scientists. The results reveal a degree of complacency among these scientists, including a sense that Germany is not particularly threatened by climate change and has the capacity to adapt to it. The scientists are critical of inaction among the German population, but themselves uphold a ''light version'' of the precautionary principle. They have great difficulty translating the idea of climate change into popular metaphors that can be grasped by children. They strongly reject any link between German leadership on the issue as a result of a sense of guilt about the German past. (orig.)

  2. A preliminary study on drought events in Peninsular Malaysia

    Science.gov (United States)

    Zin, Wan Zawiah Wan; Nahrawi, Siti Aishah; Jemain, Abdul Aziz; Zahari, Marina

    2014-06-01

    In this research, the Standard Precipitation Index (SPI) is used to represent the dry condition in Peninsular Malaysia. To do this, data of monthly rainfall from 75 stations in Peninsular Malaysia is used to obtain the SPI values at scale one. From the SPI values, two drought characteristics that are commonly used to represent the dry condition in an area that is the duration and severity of a drought period are identified and their respective values calculated for every station. Spatial mappings are then used to identify areas which are more likely to be affected by longer and more severe drought condition from the results. As the two drought characteristics may be correlated with each other, the joint distribution of severity and duration of dry condition is considered. Bivariate copula model is used and five copula models were tested, namely, the Gumbel-Hougard, Clayton, Frank, Joe and Galambos copulas. The copula model, which best represents the relationship between severity and duration, is determined using Akaike information criterion. The results showed that the Joe and Clayton copulas are well-fitted by close to 60% of the stations under study. Based on the results on the most appropriate copula-based joint distribution for each station, some bivariate probabilistic properties of droughts can then be calculated, which will be continued in future research.

  3. Preliminary studies on hoof characteristics in Amiata donkey

    Directory of Open Access Journals (Sweden)

    Alessandro Giorgetti

    2012-01-01

    Full Text Available In this work the biometrical, physical and chemical characteristics of Amiata donkey hoof were studied. The Amiata donkey is a local endangered breed and derives from the homonym mountain in Tuscany. This donkey, which was once used as pack animal in farms and in mines, is now involved in trekking, onotherapy and milk production. The mean hoof biometrics and its standard deviation were calculated. The physical and chemical characteristics were also estimated, through ANOVA, considering the hoof region as fixed effect: wall, white line and sole for hardness, wall and sole for chemical characteristics. The small size and healthy hoof, was basically cylindrical (crown cir./Foot plantar circ. ratio=0.9 and it showed higher hardness in wall (H=126.5± 3.3, followed by sole (H=105.2±3.3, and white line (H=74.0±3.3. The wall has shown the lower moisture content (%=11.7±3.2 and the higher content in Al, Mn, Li, Ni, Pb, Se. The positive correlation between Al, Li, Pb and Hardness has shown the hoof high resistence to toxic elements. Very interesting has seemed the negative correlation between K vs Li and Pb, to indicate the tendency of K to remove potentially harmful elements.

  4. Preliminary Study of ONB in Narrow-Vertical Rectangular Channel

    International Nuclear Information System (INIS)

    Omar, S. AL-Yahia; Jo, Daeseong

    2015-01-01

    The location where the vapor bubble can first exist at the heated surface is called 'onset of nucleate boiling (ONB). The subcooled boiling is highly efficient to remove the heat owing to the high heat transfer coefficient. The heat transfer is affected by the motion of the bulk liquid as well as the latent heat transport of the liquid microlayer between the bubble and the heated wall. However, with increasing in the wall temperature, the bubble growth will increase and may they aggregate at the heated surface forming a vapor film, which will prevent the heat transport from the wall and that leads to highly rise in wall temperature. This phenomenon called departure from nucleate boiling (DNB). Many experimental and numerical CFD methods were carried out to investigate the subcooled boiling because of its importance in the industrial applications. In the present study, vertical narrow rectangular channel heated from both side was simulated by using CFX-14 to investigate the subcooled wall boiling, and identical simulation is done by using TMAP to compare the ONB location between numerical simulation and empirical correlations that implemented in TMAP. The numerical results using CFX-14 are discussed and compared with the results obtained from TMAP. The coolant temperature increases gradually (linearly) in the downward direction owing to the uniform applied heat flux.

  5. Preliminary Study of ONB in Narrow-Vertical Rectangular Channel

    Energy Technology Data Exchange (ETDEWEB)

    Omar, S. AL-Yahia; Jo, Daeseong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    The location where the vapor bubble can first exist at the heated surface is called 'onset of nucleate boiling (ONB). The subcooled boiling is highly efficient to remove the heat owing to the high heat transfer coefficient. The heat transfer is affected by the motion of the bulk liquid as well as the latent heat transport of the liquid microlayer between the bubble and the heated wall. However, with increasing in the wall temperature, the bubble growth will increase and may they aggregate at the heated surface forming a vapor film, which will prevent the heat transport from the wall and that leads to highly rise in wall temperature. This phenomenon called departure from nucleate boiling (DNB). Many experimental and numerical CFD methods were carried out to investigate the subcooled boiling because of its importance in the industrial applications. In the present study, vertical narrow rectangular channel heated from both side was simulated by using CFX-14 to investigate the subcooled wall boiling, and identical simulation is done by using TMAP to compare the ONB location between numerical simulation and empirical correlations that implemented in TMAP. The numerical results using CFX-14 are discussed and compared with the results obtained from TMAP. The coolant temperature increases gradually (linearly) in the downward direction owing to the uniform applied heat flux.

  6. Preliminary Study on the Revision of Nuclear Safety Policy Statement

    International Nuclear Information System (INIS)

    Lee, Y. E.; Lee, S. H.; Chang, H. S.; Choi, K. S.; Jung, S. J.

    2011-01-01

    Nuclear safety policy in Korea is currently declared in the Nuclear Safety Charter as the highest tier document and safety principles and directions are announced in the Nuclear Safety Policy Statement. As the circumstances affecting on the nuclear safety policy change, it needs to revise the Statement. This study aims to develop the revised Nuclear Safety Policy Statement to declare that securing safety is a prerequisite to the utilization of nuclear energy, and that all workers in nuclear industry and regulatory body must adhere to the principle of priority to safety. As a result, two different types of revision are being prepared as of August. One is based on the spirit of Nuclear Safety Charter as well as the direction of future-oriented safety policies including the changes in the environment after declaration of the Statement. The other is to declare the fundamental safety objective and safety principles as the top philosophy of national nuclear safety policy by adopting the '10 Safety Principles in IAEA Safety Fundamental' instead of the current Charter. Both versions of revision are subject to further in-depth discussion. However once the revision is finalized and declared, it would be useful to accomplish effectively the organizational responsibilities and to enhance the public confidence in nuclear safety by performing the regulatory activities in a planned and systematic manner and promulgating the government's dedication to priority to safety

  7. Preliminary study on the flow field over Greece

    International Nuclear Information System (INIS)

    Pissimanis, D; Karras, G; Notaridou, V; Bartzis, J.G.

    1989-02-01

    Full text: For radiation risk assessment from long distance sources, the knowledge of the synoptic air flow field patterns over the territory under consideration is required. In the present study a first representation of the air flow field in the atmospheric boundary layer over Greece is attempted. For this purpose, synoptic weather maps at 850mb available for a ten-years period, as well as sounding data from six meteorological stations were utilized, while the Greek territory was divided into four parts, i.e. NW, NE, SW, SE, with a number of stations in each sector. It was shown that the prevailing wind directions of the upper flow are either of the W/SW sector (winter, spring) or the northern sector (summer, autumn). In the SE sector a stronger tendency towards winds from the nothern sector was shown, due to the thermal low near Cyprus. The main characteristics of the surface flow is the strong influence by topographical features. Typical examples are the strong NW winds in Northern Greece due to the Vardar Valley, and the sea breeze circulations at coastal environments. (author)

  8. Proton MR spectroscopy in solitary pulmonary nodules: a preliminary study

    International Nuclear Information System (INIS)

    Yang Chunshan; Xiao Xiangsheng; Li Huimin; Liu Shiyuan; Li Chengzhou; Li Shenjiang

    2005-01-01

    Objective: To study the characteristics and the regularities of the metabolites in solitary pulmonary nodules with proton MR spectroscopy, and to investigate the clinical value of MR spectroscopy in differentiating benign from malignant pulmonary nodules. Methods: Sixty-nine patients with solitary pulmonary nodules underwent routine MRI and single-voxel MR spectroscopy using Siemens Vision 1.5 T MR system. MR spectroscopy characteristics and parameters of the metabolites were observed and recorded. Ten pathologic specimens were examined with single-voxel MR spectroscopy. The MR spectroscopy results of the pathologic specimens were compared with those of the solitary pulmonary nodules in vivo. Results: The Cho peak (2.86 ± 1.89) of the malignant nodules was higher than that of the inflammatory (0.87 ± 0.74), tuberculous nodules (0.97 ± 1.09), and hamartoma (0.42 ± 0.53) (P 0.05). Conclusion: MR spectroscopy is reliable in evaluating pulmonary nodules in vivo. The Cho peak, Cho/Cr, and Lac peak of the malignant nodules were higher than those of inflammatory, tuberculous nodules, and hamartoma. MR spectroscopy is helpful in differentiating benign from malignant pulmonary nodules. (authors)

  9. Preliminary Study on the Development of Quantitative Safety Culture Index

    International Nuclear Information System (INIS)

    Lee, Young Eal; Kim, Hun Sil; Ahn, Nam Sung

    2005-01-01

    Safety culture is that assembly of characteristics and attitudes in organizations and individuals which establishes that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance. Because it needs to be recognized as the most significant consciousness to achieve the nuclear safety performance, Korean government and nuclear power generation company have tried to develop the practical method to improve the safety culture from the long term point view. In this study, based on the site interviews to define the potential issues on organizational behavior for the safe operation and the survey on the level of safety culture of occupied workers are conducted. Survey results are quantified as a few indicators of nuclear safety by the statistical method and it can be simulated by the dynamic modeling as time goes on. Currently index and dynamic modeling are still being developed, however, results can be used to suggest the long term strategy which safety is clearly integrated into all activities in the nuclear organization

  10. Preliminary study on computer automatic quantification of brain atrophy

    International Nuclear Information System (INIS)

    Li Chuanfu; Zhou Kangyuan

    2006-01-01

    Objective: To study the variability of normal brain volume with the sex and age, and put forward an objective standard for computer automatic quantification of brain atrophy. Methods: The cranial volume, brain volume and brain parenchymal fraction (BPF) of 487 cases of brain atrophy (310 males, 177 females) and 1901 cases of normal subjects (993 males, 908 females) were calculated with the newly developed algorithm of automatic quantification for brain atrophy. With the technique of polynomial curve fitting, the mathematical relationship of BPF with age in normal subjects was analyzed. Results: The cranial volume, brain volume and BPF of normal subjects were (1 271 322 ± 128 699) mm 3 , (1 211 725 ± 122 077) mm 3 and (95.3471 ± 2.3453)%, respectively, and those of atrophy subjects were (1 276 900 ± 125 180) mm 3 , (1 203 400 ± 117 760) mm 3 and BPF(91.8115 ± 2.3035)% respectively. The difference of BPF between the two groups was extremely significant (P 0.05). The expression P(x)=-0.0008x 2 + 0.0193x + 96.9999 could accurately describe the mathematical relationship between BPF and age in normal subject (lower limit of 95% CI y=-0.0008x 2 +0.0184x+95.1090). Conclusion: The lower limit of 95% confidence interval mathematical relationship between BPF and age could be used as an objective criteria for automatic quantification of brain atrophy with computer. (authors)

  11. Human immunotoxicologic markers of chemical exposures: preliminary validation studies.

    Science.gov (United States)

    Wartenberg, D; Laskin, D; Kipen, H

    1993-01-01

    The circulating cells of the immune system are sensitive to environmental contaminants, and effects are often manifested as changes in the cell surface differentiation antigens of affected populations of cells, particularly lymphocytes. In this investigation, we explore the likelihood that variation in the expression of the surface markers of immune cells can be used as an index of exposure to toxic chemicals. We recruited 38 healthy New Jersey men to study pesticides effects: 19 orchard farmers (high exposure); 13 berry farmers (low exposure); and 6 hardware store owners (no exposure). Immunophenotyping was performed assaying the following cell surface antigens: CD2, CD4, CD8, CD14, CD20, CD26, CD29, CD45R, CD56, and PMN. Data were analyzed using univariate and multivariate methods. There were no significant differences among the groups with respect to routine medical histories, physical examinations, or routine laboratory parameters. No striking differences between groups were seen in univariate tests. Multivariate tests suggested some differences among groups and limited ability to correctly classify individuals based on immunophenotyping results. Immunophenotyping represents a fruitful area of research for improved exposure classification. Work is needed both on mechanistic understanding of the patterns observed and on the statistical interpretation of these patterns.

  12. Influence of study satisfaction on academic procrastination in psychology students: a preliminary study

    Directory of Open Access Journals (Sweden)

    Sergio Alexis Dominguez-Lara

    2017-06-01

    Full Text Available The aim of this predictive study was to analyze the degree of influence of study satisfaction (SS on academic procrastination (AP. One hundred forty- eight (148 psychology students (111 women between 18 and 32 years old (M = 22.41 were evaluated using the Brief Scale of Study Satisfaction and the Academic Procrastination Scale. After preliminary analyses focused on the scores reliability (α > 0.70 and correlations between dimensions, a regression analysis was performed to determine how much of the variability in the AP dimensions’ scores is explained by the variations in the SS. For that purpose, a method that uses bivariate correlations corrected for attenuation and provides confidence intervals under a bootstrap approach of the associated statistics was applied. All analyses were assessed from an effect size approach. The results indicate that the influence of SS on AP was not significant. These findings provide new ways to implement studies in order to understand the procrastinating behavior in the university setting.

  13. Risk of caries and oral health: preliminary study

    Directory of Open Access Journals (Sweden)

    Marcello Gatti

    2009-12-01

    Full Text Available Introduction. The incidence of injury cariosa remains high, despite the improvements achieved in the last years. Recent national epidemiological surveys, 4 years old children have healthy teeth in 80% of cases at 12 years the percentage is reduced to 50%. In Italy, the almost total absence on the territory of “dental services to the Community”, makes even more difficult to achieve a solution to the problem “caries.” To address this problem, the Ministry of Labor, Health and Social Policy in October 2008 adopted the national guidelines in order to make suggestions to the various professionals (pediatricians, dentists, microbiologists, dental hygienists, etc., making them interact to maintain and restore oral health. It was the first time that the Ministry of Health has addressed the problem by inserting the figure of the microbiologist in dentistry. Aims. The present study aim was to identify subjects at risk of caries by clinical microbiological testing of saliva and the index DMFT/dmft (Decayed, Missing and Filling Permanent Teeth in both adults and particularly children in order to take preventive measures early as reported in “National guidelines for the promotion of oral health and prevention of oral diseases in age of development”. The study began in June 2009 and will last one year with as goal to have, in 2010, 90% of children between 5 and 6 years caries free and 18 years with any lost tooth decay. Materials and methods. Recruited 164 patients were divided into three age groups: 124 adults aged between 20 and 40 years, 40 children which 21 till 5 years old and 19 till 12 years old. Microbiological testing was aimed by finding CFU / ml of saliva of Streptococcus mutans and Lactobacillus spp., Slide CRT bacteria (Ivoclar. Clinically, intraoral examination was performed to evaluate the DMFT (Decayed teeth, Missing or Filling calculated over 28 permanent teeth and the dmft (decayed teeth, missing or filling calculated on 20

  14. Radiolabeling, characterization and preliminary studies of 90Y-octreotate

    International Nuclear Information System (INIS)

    Klementyeva, O.E.; Bruskin, A.B.; Larenkov, A.A.; Kodina, G.E.; Korsunsky, V.N.

    2015-01-01

    Full text of publication follows. Introduction: Overexpression of the somatostatin receptors in neuroendocrine tumors has become the molecular basis for the use of somatostatin analogues in diagnosis and therapy for these neoplasms. The high energy (maximum 2.2 MeV) and penetration range (R 95 5.7 mm) of β-particles from 90 Y are advantageous, with a direct killing of somatostatin receptor positive cells and a crossfire effect which hits nearby receptor-negative tumour cells [Ref. 1]. Aim: the investigation of the reaction conditions for the preparation of 90 Y-Octreotate and its in vitro characterization. Materials and methods: DOTA-Octreotate (Farm-Syntez Ltd.) and 88 YCl 3 (V/O Isotop) were used without purification. 88 Y-Octreotate was prepared in acetate buffer solution and its radiochemical purity was controlled by ITLC. In-vitro experiments were carried out with melanoma B16. Studies of internalization were performed as described in [Ref. 2]. Results: the maximal accumulation in the cells was observed after 90 min from the beginning of incubation and was about 3.9%. In our experiments, we found high level of internalization of the surface-bound 88 Y-Octreotate into B16 cells. Maximal internalization level was 80% after 60 min of incubation. Conclusion: the optimal conditions for effective labeling (> 95%) of DOTA-Octreotate were found. The results obtained using the gamma-emitting 88 Y, provide a basis for in vivo research 90 Y octreotate as radiotherapeutic agent. References: [Ref. 1] Bodei, L.; Pepe, G.; Paganelli, G.; Peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors with somatostatin analogues. Eur. Rev. Med. Pharmacol. Sci., 2010; v. 14: 347-351. [Ref. 2] Garcia Garayoa E., Allemann-Tannahill L., et al. In vitro and in vivo evaluation of new radiolabeled neurotensin (8-13) analogs with high affinity for NT1 receptors. Nucl. Med. Biol. 2001; 28: 75-84. (authors)

  15. Preliminary study of uranium favorability of the Boulder batholith, Montana

    International Nuclear Information System (INIS)

    Castor, S.B.; Robins, J.W.

    1978-01-01

    The Boulder batholith of southwestern Montana is a composite Late Cretaceous intrusive mass, mostly composed of quartz monzonite and granodiorite. This study was not restricted to the plutonic rocks; it also includes younger rocks that overlie the batholith, and older rocks that it intrudes. The Boulder batholith area has good overall potential for economic uranium deposits, because its geology is similar to that of areas that contain economic deposits elsewhere in the world, and because at least 35 uranium occurrences of several different types are present. Potential is greatest for the occurrence of small uranium deposits in chalcedony veins and base-metal sulfide veins. Three areas may be favorable for large, low-grade deposits consisting of a number of closely spaced chalcedony veins and enriched wall rock; the Mooney claims, the Boulder area, and the Clancy area. In addition, there is a good possibility of by-product uranium production from phosphatic black shales in the project area. The potential for uranium deposits in breccia masses that cut prebatholith rocks, in manganese-quartz veins near Butte, and in a shear zone that cuts Tertiary rhyolite near Helena cannot be determined on the basis of available information. Low-grade, disseminated, primary uranium concentrations similar to porphyry deposits proposed by Armstrong (1974) may exist in the Boulder batholith, but the primary uranium content of most batholith rocks is low. The geologic environment adjacent to the Boulder batholith is similar in places to that at the Midnite mine in Washington. Some igneous rocks in the project area contain more than 10 ppM U 3 O 8 , and some metasedimentary rocks near the batholith contain reductants such as sulfides and carbonaceous material

  16. Preliminary design study of the Tandem Mirror Reactor (TMR)

    International Nuclear Information System (INIS)

    Moir, R.W.; Barr, W.L.; Carlson, G.A.

    1978-01-01

    This report describes work done in Fiscal Year 1977 by the Fusion Reactor Studies Group of LLL on the conceptual design of a 1000-MW(e) Tandem Mirror Reactor (TMR). The high Q (defined as the ratio of fusion power to injection power) predicted for the TMR (approximately 5) reduces the recirculating power to a nondominant problem and results in an attractive mirror fusion power plant. The fusion plasma of the TMR is contained in the 100-m-long central cell where the magnetic field strength is a modest 2 T. The blanket for neutron energy recovery and tritium breeding is cylindrical and, along with the solenoidal magnet, is divided into 3-m-long modules to facilitate maintenance. The central cell is fueled (but not heated) by the injection of low-energy neutral beams near its ends. Thus, the central cell is simple and of low technology. The end-cell plasmas must be of high density and high energy in order to plug and heat (via the electrons) the central-cell plasma. The present conceptual design uses 1.2-MeV neutral-beam injection for the end plugs and a cryogenic-aluminum, Yin-Yang magnet that produces an incremental field of about 1 T over a field of 16 T produced by a pair of Nb 3 Sn superconducting solenoids. Important design problems remain in both the neutral-beam injector and in the end-plug magnet. Also remaining are important physics questions such as alpha-beam particle transport and end-plug stability. These questions are discussed at length in the report and suggestions for future work are given

  17. Magnetization transfer analysis of cartilage repair tissue: a preliminary study

    International Nuclear Information System (INIS)

    Palmieri, F.; Keyzer, F. de; Maes, F.; Breuseghem, I. van

    2006-01-01

    To evaluate the magnetization transfer ratio (MTR) after two different cartilage repair procedures, and to compare these data with the MTR of normal cartilage. Twenty-seven patients with a proven cartilage defect were recruited: 13 were treated with autologous chondrocyte implantation (ACI) and 14 were treated with the microfracture technique (MFR). All patients underwent MRI examinations with MT-sequences before the surgical treatment, after 12 months (26 patients) and after 24 months (11 patients). Eleven patients received a complete follow-up study at all three time points (five of the ACI group and six of the MFR group). All images were transferred to a workstation to calculate MTR images. For every MT image set, different ROIs were delineated by two radiologists. Means were calculated per ROI type in the different time frames and in both groups of cartilage repair. The data were analyzed with unpaired t- and ANOVA tests, and by calculating Pearson's correlation coefficient. No significant differences were found in the MTR of fatty bone marrow, muscle and normal cartilage in the different time frames. There was a significant but small difference between the MTR of normal cartilage and the cartilage repair area after 12 months for both procedures. After 24 months, the MTR of ACI repaired cartilage (0.31±0.07) was not significantly different from normal cartilage MTR (0.34±0.05). The MTR of MFR repaired cartilage (0.28±0.02), still showed a significant difference from normal cartilage. The differences between damaged and repaired cartilage MTR are too small to enable MT-imaging to be a useful tool for postoperative follow-up of cartilage repair procedures. There is, however, an evolution towards normal MTR-values in the cartilage repair tissue (especially after ACI repair). (orig.)

  18. Vessel encoded arterial spin labeling with cerebral perfusion: preliminary study

    International Nuclear Information System (INIS)

    Wu Bing; Xiao Jiangxi; Xie Cheng; Wang Xiaoying; Jiang Xuexiang; Wong, E.C.; Wang Jing; Guo Jia; Zhang Beiru; Zhang Jue; Fang Jing

    2008-01-01

    Objective: To evaluate a noninvasive vessel encoded imaging for selective mapping of the flow territories of the left and fight internal carotid arteries and vertebral-basilar arteries. Methods: Seven volunteers [(33.5 ± 4.1) years; 3 men, 4 women] and 6 patients [(55.2 ± 3.2) years; 2 men, 4 women] were given written informed consent approved by the institutional review board before participating in the study. A pseudo-continuous tagging pulse train is modified to encode all vessels of interest. The selectivity of this method was demonstrated. Regional perfusion imaging was developed on the same arterial spin labeling sequence. Perfusion-weighted images of the selectively labeled cerebral arteries were obtained by subtraction of the labeled from control images. The CBF values of hemisphere, white matter, and gray matter of volunteers were calculated. The vessel territories on patients were compared with DSA. The low perfusion areas were compared with high signal areas on T 2 -FLAIR. Results: High SNR maps of left carotid, right carotid, and basilar territories were generated in 8 minutes of scan time. Cerebral blood flow values measured with regional perfusion imaging in the complete hemisphere (32.6 ± 4.3) ml·min -1 · 100 g -1 , white matter (10.8 ± 0.9) ml·min -1 ·100 g -1 , and gray matter (55.6±2.9) ml·min -1 · 100 g -1 were in agreement with data in the literature. Vessel encoded imaging in patients had a good agreement with DSA. The low perfusion areas were larger than high signal areas on T 2 -FLAIR. Conclusion: We present a new method capable of evaluating both quantitatively and qualitatively the individual brain- feeding arteries in vivo. (authors)

  19. Preliminary study of uranium favorability of the Boulder batholith, Montana

    Energy Technology Data Exchange (ETDEWEB)

    Castor, S.B.; Robins, J.W.

    1978-01-01

    The Boulder batholith of southwestern Montana is a composite Late Cretaceous intrusive mass, mostly composed of quartz monzonite and granodiorite. This study was not restricted to the plutonic rocks; it also includes younger rocks that overlie the batholith, and older rocks that it intrudes. The Boulder batholith area has good overall potential for economic uranium deposits, because its geology is similar to that of areas that contain economic deposits elsewhere in the world, and because at least 35 uranium occurrences of several different types are present. Potential is greatest for the occurrence of small uranium deposits in chalcedony veins and base-metal sulfide veins. Three areas may be favorable for large, low-grade deposits consisting of a number of closely spaced chalcedony veins and enriched wall rock; the Mooney claims, the Boulder area, and the Clancy area. In addition, there is a good possibility of by-product uranium production from phosphatic black shales in the project area. The potential for uranium deposits in breccia masses that cut prebatholith rocks, in manganese-quartz veins near Butte, and in a shear zone that cuts Tertiary rhyolite near Helena cannot be determined on the basis of available information. Low-grade, disseminated, primary uranium concentrations similar to porphyry deposits proposed by Armstrong (1974) may exist in the Boulder batholith, but the primary uranium content of most batholith rocks is low. The geologic environment adjacent to the Boulder batholith is similar in places to that at the Midnite mine in Washington. Some igneous rocks in the project area contain more than 10 ppM U/sub 3/O/sub 8/, and some metasedimentary rocks near the batholith contain reductants such as sulfides and carbonaceous material.

  20. Endometrial preparation with desogestrel before Essure hysteroscopic sterilization: preliminary study.

    Science.gov (United States)

    Haimovich, Sergio; Mancebo, Gemma; Alameda, Francesc; Agramunt, Silvia; Hernández, José Luis; Carreras, Ramón

    2013-01-01

    To assess the effect of desogestrel on endometrial preparation for transcervical sterilization using the Essure device. Prospective nonrandomized clinical study (Canadian Task Force classification II-3). Acute-care university-affiliated hospital in Barcelona, Spain. Women undergoing sterilization using the Essure device between January 2010 and January 2011. Participants were offered desogestrel, 75 μg/d, for 6 weeks before the procedure. Sixteen who accepted were included in the desogestrel group, and 18 who refused were allocated to the no-treatment group. Endometrial biopsy samples were also obtained. In women who received desogestrel, decidual transformation was observed in eight, glandular atrophy in three, and proliferative endometrium in five. In the no-treatment group, two women had menstruation, nine had proliferative endometrium, and seven had secretory endometrium. In the desogestrel group, the procedure was successful in all women. In the no-treatment group, the procedure was cancelled in two women because of menstruation and in four women with secretory endometrium in whom the tubal ostia were difficult to visualize because of endometrial thickness and bleeding. The median (interquartile range, 25th-75th percentile) duration of the procedure was shorter in the desogestrel group than in the no-treatment group (7 [6-7] minutes vs 8 [7-12] minutes; p = .002). Desogestrel, 75 μg/d, could be an alternative to combined hormonal contraception before placement of Essure inserts, facilitating the procedure and serving as a contraceptive method during the following 12 weeks until occlusion of the tubes. Copyright © 2013 AAGL. Published by Elsevier Inc. All rights reserved.

  1. Magnetic resonance elastography in normal human brain: preliminary study

    International Nuclear Information System (INIS)

    Xu Lei; Gao Peiyi; Lin Yan; Han Jiancheng; Xi Zhinong; Shen Hao

    2007-01-01

    Objective: To study the application of magnetic resonance elastography (MRE) in the human brain. Methods: An external force actuator was developed. The actuator was fixed to the head coil. During MRE scan, one side of the actuator was attached to the volunteers' head. Low frequency oscillation was produced by the actuator and generated shear waves propagating into brain tissue. The pulse sequence of MRE was designed. A modified gradient echo sequence was developed with motion sensitizing gradient (MSG) imposed along X, Y or Z direction. Cyclic displacement within brain tissue induced by shear waves caused a measurable phase shift in the received MR signal. From the measured phase shift, the displacement at each voxel could be calculated, and the shear waves within the brain were directly imaged. By adjusting the phase offset, the dynamic propagation of shear waves in a wave cycle was obtained. Phase images were processed with local frequency estimation (LFE) technique to obtain the elasticity images. Shear waves at 100 Hz, 150 Hz, and 200 Hz were applied. Results: The phase images of MRE directly imaged the propagating shear waves within the brain. The direction of the propagation was from surface of the brain to the center. The wavelength of shear waves varied with the change of actuating frequency. The change of wavelength of shear waves in gray and white matter of the brain was identified. The wavelength of shear waves in gray matter was shorter than that in white matter. The elasticity image of the brain revealed that the shear modulus of the white matter was higher than that of gray matter. Conclusion: The phase images of MRE can directly visualize the propagation of shear waves in the brain tissue. The elasticity image of the brain can demonstrate the change of elasticity between gray and white matter. (authors)

  2. Preliminary study of diffusion effects in Fricke gel dosimeters

    Energy Technology Data Exchange (ETDEWEB)

    Quiroga, A. [Centro de Investigacion y Estudios de Matematica de Cordoba, Oficina 318 FaMAF - UNC, Ciudad Universitaria, 5000 Cordoba (Argentina); Vedelago, J. [Laboratorio de Investigaciones e Instrumentacion en Fisica Aplicada a la Medicina e Imagenes por Rayos X, Laboratorio 448 FaMAF - UNC, Ciudad Universitaria, 5000 Cordoba (Argentina); Valente, M., E-mail: aiquiroga@famaf.unc.edu [Instituto de Fisica Enrique Gaviola, Oficina 102 FaMAF - UNC, Av. Luis Medina Allende, Ciudad Universitaria, 5000 Cordoba (Argentina)

    2014-08-15

    Diffusion of ferric ions in ferrous sulfate (Fricke) gels represents one of the main drawbacks of some radiation detectors, like Fricke gel dosimeters. In practice, this disadvantage can be overcome by prompt dosimeter analysis, constraining strongly the time between irradiation and analysis. Due to required integral accuracy levels, special dedicated protocols are implemented with the aim of minimizing signal blurring due to diffusion effects. This work presents dedicated analytic modelling and numerical calculations of diffusion coefficients in Fricke gel radiation sensitive material. Samples are optically analysed by means of visible light transmission measurements capturing images with a Ccd camera provided with a monochromatic 585 nm filter corresponding to the X O-infused Fricke solution absorbance peak. Dose distributions in Fricke gels are suitably delivered in order to assess specific initial conditions further studied by periodical sample image acquisitions. In a first analytic approach, experimental data are fit with linear models in order to achieve a value for the diffusion coefficient. The second approach to the problem consists on a group of computational algorithms based on inverse problem formulation, along with suitable 2D diffusion model capable of estimating diffusion coefficients by fitting the obtained algorithm numerical solutions with the corresponding experimental data. Comparisons are performed by introducing an appropriate functional in order to analyse both experimental and numerical values. Solutions to second order diffusion equation are calculated in the framework of a dedicated method that incorporates Finite Element Method. Moreover, optimised solutions can be attained by gradient type minimisation algorithms. Knowledge about diffusion coefficient for Fricke gel radiation detector might be helpful in accounting for effects regarding elapsed time between dosimeter irradiation and further analysis. Hence, corrections might be included

  3. Preliminary study of diffusion effects in Fricke gel dosimeters

    International Nuclear Information System (INIS)

    Quiroga, A.; Vedelago, J.; Valente, M.

    2014-08-01

    Diffusion of ferric ions in ferrous sulfate (Fricke) gels represents one of the main drawbacks of some radiation detectors, like Fricke gel dosimeters. In practice, this disadvantage can be overcome by prompt dosimeter analysis, constraining strongly the time between irradiation and analysis. Due to required integral accuracy levels, special dedicated protocols are implemented with the aim of minimizing signal blurring due to diffusion effects. This work presents dedicated analytic modelling and numerical calculations of diffusion coefficients in Fricke gel radiation sensitive material. Samples are optically analysed by means of visible light transmission measurements capturing images with a Ccd camera provided with a monochromatic 585 nm filter corresponding to the X O-infused Fricke solution absorbance peak. Dose distributions in Fricke gels are suitably delivered in order to assess specific initial conditions further studied by periodical sample image acquisitions. In a first analytic approach, experimental data are fit with linear models in order to achieve a value for the diffusion coefficient. The second approach to the problem consists on a group of computational algorithms based on inverse problem formulation, along with suitable 2D diffusion model capable of estimating diffusion coefficients by fitting the obtained algorithm numerical solutions with the corresponding experimental data. Comparisons are performed by introducing an appropriate functional in order to analyse both experimental and numerical values. Solutions to second order diffusion equation are calculated in the framework of a dedicated method that incorporates Finite Element Method. Moreover, optimised solutions can be attained by gradient type minimisation algorithms. Knowledge about diffusion coefficient for Fricke gel radiation detector might be helpful in accounting for effects regarding elapsed time between dosimeter irradiation and further analysis. Hence, corrections might be included

  4. Second vowel formant relationship to adduction: A preliminary study

    Science.gov (United States)

    Hanrahan, Kevin G.

    cases, but overall the data was inconclusive. Further study is needed to clarify.

  5. Mathematical models used to inform study design or surveillance systems in infectious diseases: a systematic review.

    Science.gov (United States)

    Herzog, Sereina A; Blaizot, Stéphanie; Hens, Niel

    2017-12-18

    Mathematical models offer the possibility to investigate the infectious disease dynamics over time and may help in informing design of studies. A systematic review was performed in order to determine to what extent mathematical models have been incorporated into the process of planning studies and hence inform study design for infectious diseases transmitted between humans and/or animals. We searched Ovid Medline and two trial registry platforms (Cochrane, WHO) using search terms related to infection, mathematical model, and study design from the earliest dates to October 2016. Eligible publications and registered trials included mathematical models (compartmental, individual-based, or Markov) which were described and used to inform the design of infectious disease studies. We extracted information about the investigated infection, population, model characteristics, and study design. We identified 28 unique publications but no registered trials. Focusing on compartmental and individual-based models we found 12 observational/surveillance studies and 11 clinical trials. Infections studied were equally animal and human infectious diseases for the observational/surveillance studies, while all but one between humans for clinical trials. The mathematical models were used to inform, amongst other things, the required sample size (n = 16), the statistical power (n = 9), the frequency at which samples should be taken (n = 6), and from whom (n = 6). Despite the fact that mathematical models have been advocated to be used at the planning stage of studies or surveillance systems, they are used scarcely. With only one exception, the publications described theoretical studies, hence, not being utilised in real studies.

  6. Preliminary studies on the popping characteristics of sorghum grains

    International Nuclear Information System (INIS)

    Hamad, R.M.E.

    2006-10-01

    The aim of this study was to specify and describe the appropriate stages of pop processing of three sorghum varieties (Safra, Engaz and Edo) then selection suitable variety for pop production and the association between its chemical composition and the ability of popping. The proximate chemical composition of the three tested sorghum varieties during the stages of processing to pop the poly phenols (phytic acid and tannins) beside starch and some minerals (the macro elements potassium, calcium and the microelements, iron and zinc) were determined. The range of chemical composition of raw sorghum varieties were as follows: moisture 8.57-9.13%; ash 1.51-2.16%; crude fat 3.39-3.62%; protein 9.06-18.58%; carbohydrates 67.41-76.58; starch 65.23-74.66; tannins 0.3.3-0.28 mg/100 g; phytic acid 2.90-4.93 mg/100 g; iron 3.43-4.58 mg/100 g; calcium 5.17-11.26 mg/100 g; zinc 1.48-2.78 mg/100 g; potassium 198.80-387.78 mg/100 g. The results showed significant difference between the three sorghum varieties. The chemical composition of the boiled stage were: moisture 11.80-13.06%; ash 1.49-2.12 %; crude fat 3.63-3.79%; crude protein 10.32-18.50%; carbohydrate 62.86-71.68; starch 64.14-74.10; tannin 0.12-0.18 mg/100 g; phytic acid 2.39-3.69 mg/100 g; iron 4.44-5.45 mg/100g; calcium 9.26-20.19 mg/100g; zinc 1.33-2.43 mg/100g; potassium 184.62-266.08 mg/100g. The chemical composition of pop sorghum products gave: moisture 3.66-4.93%; ash 1.49-2.35%, crude fat 3.61-3.91%; crude protein 9.13-15.82%; carbohydrates 74.56-81.06%; starch 70.14-77.58%; tannins 0.29-0.34 mg/100g; phytic acid 0.93-2.23 mg/100g; iron 3.65-79 mg/100g; calcium 18.72-23.09 mg/100g; zinc 1.45-2.48 mg/100g; potassium 190.53-322.44 mg/100g. The variety Engaz was most acceptable in organoleptic evaluation in all the tested characters: color, flavors (odor and taste) and texture taking pop corn as the control followed by the variety Edo while Safra was least acceptable in popping the ability of the varieties for

  7. Preliminary studies on the popping characteristics of sorghum grains

    Energy Technology Data Exchange (ETDEWEB)

    Hamad, R M.E. [Agricultural Research Council, Sudan Academy of Sciences, Khartoum (Sudan)

    2006-10-15

    The aim of this study was to specify and describe the appropriate stages of pop processing of three sorghum varieties (Safra, Engaz and Edo) then selection suitable variety for pop production and the association between its chemical composition and the ability of popping. The proximate chemical composition of the three tested sorghum varieties during the stages of processing to pop the poly phenols (phytic acid and tannins) beside starch and some minerals (the macro elements potassium, calcium and the microelements, iron and zinc) were determined. The range of chemical composition of raw sorghum varieties were as follows: moisture 8.57-9.13%; ash 1.51-2.16%; crude fat 3.39-3.62%; protein 9.06-18.58%; carbohydrates 67.41-76.58; starch 65.23-74.66; tannins 0.3.3-0.28 mg/100 g; phytic acid 2.90-4.93 mg/100 g; iron 3.43-4.58 mg/100 g; calcium 5.17-11.26 mg/100 g; zinc 1.48-2.78 mg/100 g; potassium 198.80-387.78 mg/100 g. The results showed significant difference between the three sorghum varieties. The chemical composition of the boiled stage were: moisture 11.80-13.06%; ash 1.49-2.12 %; crude fat 3.63-3.79%; crude protein 10.32-18.50%; carbohydrate 62.86-71.68; starch 64.14-74.10; tannin 0.12-0.18 mg/100 g; phytic acid 2.39-3.69 mg/100 g; iron 4.44-5.45 mg/100g; calcium 9.26-20.19 mg/100g; zinc 1.33-2.43 mg/100g; potassium 184.62-266.08 mg/100g. The chemical composition of pop sorghum products gave: moisture 3.66-4.93%; ash 1.49-2.35%, crude fat 3.61-3.91%; crude protein 9.13-15.82%; carbohydrates 74.56-81.06%; starch 70.14-77.58%; tannins 0.29-0.34 mg/100g; phytic acid 0.93-2.23 mg/100g; iron 3.65-79 mg/100g; calcium 18.72-23.09 mg/100g; zinc 1.45-2.48 mg/100g; potassium 190.53-322.44 mg/100g. The variety Engaz was most acceptable in organoleptic evaluation in all the tested characters: color, flavors (odor and taste) and texture taking pop corn as the control followed by the variety Edo while Safra was least acceptable in popping the ability of the varieties for

  8. Assessing Internet addiction using the parsimonious Internet addiction components model - a preliminary study [forthcoming

    OpenAIRE

    Kuss, DJ; Shorter, GW; Van Rooij, AJ; Griffiths, MD; Schoenmakers, T

    2014-01-01

    Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (2005), i...

  9. Assessing internet addiction using the parsimonious internet addiction components model—A preliminary study.

    OpenAIRE

    Kuss, D.J.; Shorter, G.W.; Rooij, A.J. van; Griffiths, M.D.; Schoenmakers, T.M.

    2014-01-01

    Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (Journal ...

  10. Preliminary study of application of Moringa oleifera resin as polymer electrolyte in DSSC solar cells

    Science.gov (United States)

    Saehana, Sahrul; Darsikin, Muslimin

    2016-04-01

    This study reports the preliminary study of application of Moringa oleifera resin as polymer electrolyte in dye-sensitized solar cell (DSSC). We found that polymer electrolyte membrane was formed by using solution casting methods. It is observed that polymer electrolyte was in elastic form and it is very potential to application as DSSC component. Performance of DSSC which employing Moringa oleifera resin was also observed and photovoltaic effect was found.

  11. Preliminary study of flotation behavior of Besham Lead-Zinc ore

    International Nuclear Information System (INIS)

    Khan, M.M.; Din, F.; Rafiq, M.

    2001-01-01

    This preliminary study examines the flotation behavior of the mineral galena from Besham Lead-Zinc ore samples with reference to the particle size, collector types such as Ethyl and Propyl xanthates and depressants. The comminution of the as mined ore was carried out in the laboratory jaw crusher and disc mill as well as in a laboratory ball mill. The material having size range between-90 microns and +63 microns was selected for flotation studies. (author)

  12. A preliminary study on the dielectric constant of WPC based on some tropical woods

    International Nuclear Information System (INIS)

    Chia, L.H.L.; Chua, P.H.; Hon, Y.S.; Lee, E.

    1986-01-01

    The use of WPC as an important insulating material is studied by determining its dielectric constant. The variation of dielectric constant with moisture content is also investigated. Preliminary results show that all untreated woods studied have a higher dielectric constant than their polymer composites with the exception of Kapur and Keruing. It is therefore postulated that the presence of polymers has led to a decrease in the number of polarizable units. Such a material may be useful commercially. (author)

  13. Journal of Island Studies: preliminary ideas from 1991, and comments from 2015

    Directory of Open Access Journals (Sweden)

    Russell King

    2015-05-01

    Full Text Available Some preliminary thoughts were penned in 1991, on the founding of an academic journal devoted to the study of the world’s islands. This collated contribution is an opportunity to look back critically at what was advised then, and what has actually come to pass through Island Studies Journal. Russell King’s prescient report from 1991 is followed by a series of candid reflections by members of ISJ’s International Editorial Board.

  14. Weldon Spring, Missouri, Raffinate Pits 1, 2, 3, and 4: Preliminary grout development screening studies for in situ waste immobilization

    International Nuclear Information System (INIS)

    McDaniel, E.W.; Gilliam, T.M.; Dole, L.R.; West, G.A.

    1987-04-01

    Results of Oak Ridge National Laboratory's initial support program to develop a preliminary grout formula to solidify in situ the Weldon Spring waste are presented. The screening study developed preliminary formulas based on a simulated composite waste and then tested the formulas on actual waste samples. Future data needs are also discussed. 1 ref., 6 figs., 9 tabs

  15. Preliminary neutronic study on Pu-based OTTO cycle pebble bed reactor

    Energy Technology Data Exchange (ETDEWEB)

    Setiadipura, Topan; Zuhair [National Nuclear Energy Agency of Indonesia (BATAN), Selatan (Indonesia). Center for Nuclear Reactor Technology and Safety; Irwanto, Dwi [Bandung Institute of Technology (ITB), Bandung (Indonesia). Nuclear Physics and Biophysics Research Group

    2017-12-15

    The neutron physics characteristic of Pebble Bed Reactor (PBR) allows a better incineration of plutonium (Pu). An optimized design of simple PBR might give a symbiotic solution of providing a safe energy source, effective fuel utilization shown by a higher burnup value, and incineration of Pu stockpiles. This study perform a preliminary neutronic design study of a 200 MWt Once Through Then Out (OTTO) cycle PBR with Pu-based fuel. The safety criteria of the design were represented by the per-fuel-pebble maximum power generation of 4.5 kW/pebble. In this preliminary phase, the parametric survey is limited to the heavy metal (HM) loading per pebble and the average axial speed of the fuel. An optimum high burnup of 419.7 MWd/kg-HM was achieved in this study. This optimum design uses a HM loading of 2.5 g/pebble with average axial fuel velocity 0.5 cm/day.

  16. A study on the development plan and preliminary design of proton accelerator for nuclear application

    Energy Technology Data Exchange (ETDEWEB)

    Eom, Tae Yoon; Choi, B H; Park, C K; Chung, K S. and others

    1997-11-01

    A study on the development plan and preliminary design for the realisation of high current proton accelerator to be used as an essential component for the R and D of accelerator-driven system (ADS) for energy production and transmutation of long-lived radionuclides. Various fields of application of the accelerator such as basic nuclear physics, material science, biology, high energy physics, medicine, etc. were also investigated. From the preliminary design study, 1 GeV (20 mA) - Linac is required for the purposed of transmutation and energy production. Specification of injector, RFQ, CCTL and SL was also suggested. For the case study, a duoplasmatron ion source was designed by KAERI and fabricated by a domestic manufacturer, and the performance was also tested. (author). 71 refs., 61 tabs., 131 figs

  17. Surgical reintervention after antireflux surgery for gastroesophageal reflux disease: a prospective cohort study in 130 patients

    NARCIS (Netherlands)

    Furnée, Edgar J. B.; Draaisma, Werner A.; Broeders, Ivo A. M. J.; Smout, Andre J. P. M.; Gooszen, Hein G.

    2008-01-01

    HYPOTHESIS: Surgical reintervention after antireflux surgery for gastroesophageal reflux disease is required in 3% to 6% of patients. The subjective outcome after reintervention has been reported in several studies, but objective results after these subsequent operations have rarely been published.

  18. Visuospatial processing in early Alzheimer’s disease: a multimodal neuroimaging study

    NARCIS (Netherlands)

    Jacobs, H.I.L.; Gronenschild, E. H. B. M.; Evers, E.A.T.; Ramakers, I.H.G.B.; Hofman, P.A.M.; Backes, W. H.; Jolles, J.; Verhey, F. R. J.

    2013-01-01

    Introduction: Dorsal pathway dysfunctions are thought to underlie visuospatial processing problems in Alzheimer disease (AD). Prior studies reported compensatory mechanisms in the dorsal or ventral pathway in response to these functional changes. Since functional and structural connectivity are

  19. The oral microbiota of Irish children in health and disease: a longitudinal and cross sectional study

    OpenAIRE

    Hurley, Eimear

    2017-01-01

    The oral cavity harbours a very rich and diverse microbial community. In the last decade, the oral microbiota of children and adults has been studied in detail using continuously developing DNA sequencing methods. In particular focusing on the oral microbiome changes in the presence of diseases such as dental caries, periodontal disease and the relationship of the oral microbiome with oral health and disease states. The overall aim of these studies was to unravel the complexity of the oral ec...

  20. OCULAR MANIFESTATIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE- A HOSPITALBASED STUDY

    Directory of Open Access Journals (Sweden)

    Shobha Ponmudy

    2017-08-01

    Full Text Available BACKGROUND Chronic kidney disease affects every organ system including the eye. The aim of the study is to conduct a thorough ocular examination and to study the occurrence of various ocular manifestations exhibited by patients with chronic kidney disease and to analyse the findings. MATERIALS AND METHODS 100 patients from Department of Nephrology, Stanley Medical College diagnosed with chronic kidney disease were examined for ocular manifestations at the Department of Ophthalmology, Stanley Medical College. This is a cross-sectional, descriptive, non-interventional, hospital-based study. The period of study was from August 2010 to October 2011. RESULTS The commonest cause of CKD was hypertension in 47 pts. (52.2% followed by both diabetes and hypertension in 30 patients. Patients with only diabetes were 6 patients (6.7% and with other causes were 7 patients (7.8%.10% of patients were legally blind with visual acuity <6/60. In this study, 65 patients belonged to less than 50 years. 49.3% of the presenile patients had cataract. A reduced Schirmer’s value was noted in 54 eyes of the 200 eyes. The incidence of ocular surface disease in the study was 27%. 92 eyes out of 200 eyes studied showed hypertensive retinopathy. Higher grades of hypertensive retinopathy was more in advanced stages of CKD, i.e. 24 eyes in stage IV and 23 eyes in stage V. 51 eyes out of 40 diabetics showed diabetic retinopathy changes of which a majority of 25 eyes belonged to stage V disease. Prevalence of diabetic retinopathy in CKD patients is significantly more when compared to diabetic patients without CKD. CONCLUSION Study demonstrates that routine ocular evaluation is necessary in all patients with chronic kidney disease irrespective of the presence of ocular symptoms. It also highlights the occurrence of a variety of treatable ocular manifestations, which can become vision threatening if not taken care of at the earliest.

  1. Health outcomes of children born to mothers with chronic kidney disease: a pilot study

    Directory of Open Access Journals (Sweden)

    Indrani Banerjee

    2010-05-01

    Full Text Available This study aimed to study the health of children born to mothers with chronic kidney disease. Twenty-four children born to mothers with chronic kidney disease were compared with 39 matched control children born to healthy mothers without kidney disease. The well-being of each child was individually assessed in terms of physical health, neurodevelopment and psychological health. Families participating with renal disease were more likely to be from lower socio-economic backgrounds. Significantly fewer vaginal deliveries were reported for mothers with renal disease and their infants were more likely to experience neonatal morbidity. Study and control children were comparable for growth parameters and neurodevelopment as assessed by the Griffiths scales. There was no evidence of more stress amongst mothers with renal disease or of impaired bonding between mother and child when compared to controls. However, there was evidence of greater externalizing behavioral problems in the group of children born to mothers with renal disease. Engaging families in such studies is challenging. Nonetheless, families who participated appreciated being asked. The children were apparently healthy but there was evidence in this small study of significant antenatal and perinatal morbidity compared to controls. Future larger multi-center studies are required to confirm these early findings.

  2. Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.

    Directory of Open Access Journals (Sweden)

    Xian-Tao Zeng

    Full Text Available BACKGROUND: Many epidemiological studies have found a positive association between periodontal disease (PD and risk of chronic obstructive pulmonary disease (COPD, but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD. METHODS: PubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software. RESULTS: Fourteen observational studies (one nested case-control, eight case-control, and five cross-sectional involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48-2.91; P<0.001, with sensitivity analysis showing that the result was robust. Subgroups analyses according to study design, ethnicity, assessment of PD/COPD, and adjusted/unadjusted odds ratios also revealed a significant association. Publication bias was detected. CONCLUSIONS: Based on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.

  3. Food pricing strategies, population diets, and non-communicable disease: a systematic review of simulation studies.

    Directory of Open Access Journals (Sweden)

    Helen Eyles

    Full Text Available BACKGROUND: Food pricing strategies have been proposed to encourage healthy eating habits, which may in turn help stem global increases in non-communicable diseases. This systematic review of simulation studies investigates the estimated association between food pricing strategies and changes in food purchases or intakes (consumption (objective 1; Health and disease outcomes (objective 2, and whether there are any differences in these outcomes by socio-economic group (objective 3. METHODS AND FINDINGS: Electronic databases, Internet search engines, and bibliographies of included studies were searched for articles published in English between 1 January 1990 and 24 October 2011 for countries in the Organisation for Economic Co-operation and Development. Where ≥ 3 studies examined the same pricing strategy and consumption (purchases or intake or health outcome, results were pooled, and a mean own-price elasticity (own-PE estimated (the own-PE represents the change in demand with a 1% change in price of that good. Objective 1: pooled estimates were possible for the following: (1 taxes on carbonated soft drinks: own-PE (n  =  4 studies, -0.93 (range, -0.06, -2.43, and a modelled -0.02% (-0.01%, -0.04% reduction in energy (calorie intake for each 1% price increase (n  =  3 studies; (2 taxes on saturated fat: -0.02% (-0.01%, -0.04% reduction in energy intake from saturated fat per 1% price increase (n  =  5 studies; and (3 subsidies on fruits and vegetables: own-PE (n = 3 studies, -0.35 (-0.21, -0.77. Objectives 2 and 3: variability of food pricing strategies and outcomes prevented pooled analyses, although higher quality studies suggested unintended compensatory purchasing that could result in overall effects being counter to health. Eleven of 14 studies evaluating lower socio-economic groups estimated that food pricing strategies would be associated with pro-health outcomes. Food pricing strategies also have the potential to reduce

  4. Development of the music therapy assessment Tool for advanced Huntington’s disease: A pilot validation study

    DEFF Research Database (Denmark)

    O'Kelly, Julian; Bodak, Rebeka

    2016-01-01

    Background: Case studies of people with Huntington's disease (HD) report that music therapy provides a range of benefits that may improve quality of life; however, no robust music therapy assessment tools exist for this population. Objective: Develop and conduct preliminary psychometric testing...... of its construct validity, internal consistency, and inter-rater and intra-rater reliability over 10 group music therapy sessions with 19 patients. Results: The resulting MATA-HD included a total of 15 items across six subscales (Arousal/Attention, Physical Presentation, Communication, Musical, Cognition......, and Psychological/Behavioral). We found good construct validity (r ≥ 0.7) for Mood, Communication Level, Communication Effectiveness, Choice, Social Behavior, Arousal, and Attention items. Cronbach's α of 0.825 indicated good internal consistency across 11 items with a common focus of engagement in therapy...

  5. PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies.

    Science.gov (United States)

    Laver, Lior; Marom, Niv; Dnyanesh, Lad; Mei-Dan, Omer; Espregueira-Mendes, João; Gobbi, Alberto

    2017-10-01

    To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis." The final result yielded 29 articles. Twenty-six studies examined PRP administration for knee OA and 3 involved PRP administration for hip OA. The results included 9 prospective randomized controlled trials (RCTs) (8 knee and 1 hip), 4 prospective comparative studies, 14 case series, and 2 retrospective comparative studies. Hyaluronic acid (HA) was used as a control in 11 studies (7 RCTs, 2 prospective comparative studies, and 2 retrospective cohort). Overall, all RCTs reported on improved symptoms compared to baseline scores. Only 2 RCTs-one for knee and one for hip-did not report significant superiority of PRP compared to the control group (HA). Nine out of 11 HA controlled studies showed significant better results in the PRP groups. A trend toward better results for PRP injections in patients with early knee OA and young age was observed; however, lack of uniformity was evident in terms of indications, inclusion criteria, and pathology definitions in the different studies. Current clinical evidence supports the benefit in PRP treatment for knee and hip OA, proven to temporarily relieve pain and improve function of the involved joint with superior results compared with several alternative treatments. Further research to establish the optimal preparation protocol and characteristics of PRP injections for OA is needed.

  6. Low incidence but poor prognosis of complicated coeliac disease: a retrospective multicentre study.

    Science.gov (United States)

    Biagi, Federico; Gobbi, Paolo; Marchese, Alessandra; Borsotti, Edoardo; Zingone, Fabiana; Ciacci, Carolina; Volta, Umberto; Caio, Giacomo; Carroccio, Antonio; Ambrosiano, Giuseppe; Mansueto, Pasquale; Corazza, Gino R

    2014-03-01

    Coeliac disease is a chronic enteropathy characterized by an increased mortality caused by its complications, mainly refractory coeliac disease, small bowel carcinoma and abdominal lymphoma. Aim of the study was to study the epidemiology of complications in patients with coeliac disease. Retrospective multicenter case-control study based on collection of clinical and laboratory data. The incidence of complicated coeliac disease was studied among coeliac patients directly diagnosed in four Italian centres. Patients referred to these centres after a diagnosis of coeliac disease and/or complicated coeliac disease in other hospitals were therefore excluded. Between 1/1999 and 10/2011, 1840 adult coeliac patients were followed up for 7364.3 person-years. Fourteen developed complications. Since five patients died, at the end of the observation period (10/2011), the prevalence of complicated coeliac disease was 9/1835 (1/204, 0.49%, 95% CI 0.2-0.9%). The annual incidence of complicated coeliac disease in the study period was 14/7364 (0.2%, 95% CI 0.1-0.31%). Although complications tend to occur soon after the diagnosis of coeliac disease, Kaplan-Meier curve analysis showed that they can actually occur at any time after the diagnosis of coeliac disease. Complications of coeliac disease in our cohort were quite rare, though characterised by a very high mortality. Copyright © 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  7. Periodontitis as a potential risk factor for chronic obstructive pulmonary disease: A retrospective study

    Directory of Open Access Journals (Sweden)

    Deo Vikas

    2009-01-01

    Full Text Available Aims and Objectives : A relationship between poor periodontal health and respiratory disease has been suggested by a number of recent studies. The present study was undertaken to evaluate potential association between respiratory diseases and periodontal health status and to co-relate the severity of periodontal disease with that of chronic obstructive pulmonary disease (COPD. Materials and Methods : 150 patients of COPD (test group and 50 Patients without COPD (control group were recruited for the study. Information regarding patient′s demographic and socioeconomic status and lifestyle (history of smoking were considered in the study. Patients with COPD were grouped into mild, moderate and severe category on the basis of Spirometry. Periodontal health was assessed by measuring probing pocket depth, Clinical Attachment Loss (CAL and Oral Hygiene Index (OHI. Results : The results showed that the subjects with COPD had significantly more mean CAL and a higher mean OHI than those without COPD. The risk for COPD appeared to be significantly elevated when attachment loss was found to be severe. A trend was noted in that lung function appeared to diminish as the amount of attachment loss increased. Conclusion : On the basis of the observed results of the study it can be concluded that the risk for COPD appeared to be significantly elevated when attachment loss was found to be severe. It is conceivable that oral interventions that improve oral health status may prove to lower the severity of lung infection in susceptible populations.

  8. Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies.

    Science.gov (United States)

    Song, Bo; Liu, Kai; Gao, Yuan; Zhao, Lu; Fang, Hui; Li, Yusheng; Pei, Lulu; Xu, Yuming

    2017-09-01

    The aim of current meta-analysis was to investigate the relation between lycopene and risk of cardiovascular diseases (CVD). Studies concerning about the association between lycopene and risk of CVD were searched on Pubmed, Embase, and Web of Science from inception to October 2016. A total of 14 eligible studies were identified. A significantly inverse association with a pooled risk ratio (RR) of 0.83 (95% CI: 0.76-0.90) was shown between lycopene exposure and risk of CVD. Findings were similar restricting to dietary studies (RR = 0.87, 95% CI = 0.79-0.96) and biomarker studies (RR = 0.74, 95% CI = 0. 62-0.87).Dietary lycopene intake was statistically significant for coronary heart disease (CHD) (RR: 0.87; 95% CI: 0.76-0.98) and stroke (RR: 0.83; 95% CI: 0.69-0.96).The pooled risk estimate was generally similar for lycopene biomarker concentrations, but the association was only statistically significant for stroke (RR: 0.65; 95% CI: 0.42-0.87). Subgroup analyses showed that retrospective and low quality studies were statistically significant sources of heterogeneity. Higher lycopene exposure is inversely associated with a lower risk of CVD. Further well-designed randomized clinical trials are required to assess the role of lycopene on CVD. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study

    DEFF Research Database (Denmark)

    El Fassi, Daniel; Nielsen, Claus H; Bonnema, Steen Joop

    2007-01-01

    be of benefit in GD. OBJECTIVE/DESIGN: The objective of this prospective, controlled, nonrandomized study was to investigate the effect of RTX in GD. SETTING/PATIENTS: We studied 20 outpatients referred to a university clinic with newly diagnosed (four with relapse) untreated GD. Ten received RTX (+RTX......), whereas 10 did not (-RTX). INTERVENTION: The patients received methimazole (MMI) for a median of 102 d (+RTX) and 110 d (-RTX) before the study. Patients in the +RTX group received 375 mg RTX/m(2) iv on d 1, 8, 15, and 22, and all patients were withdrawn from methimazole (MMI) at d 22. MAIN OUTCOME...... in remission had initial TRAb levels below 5 IU/liter (normal, liter). However, none of the five patients in the -RTX group with correspondingly low TRAb levels were in remission (P

  10. The Helicobacter pylori theory and duodenal ulcer disease. A case study of the research process

    DEFF Research Database (Denmark)

    Christensen, A H; Gjørup, T

    1995-01-01

    should be selected for H. pylori eradication treatment. CONCLUSION: Descriptive clinical studies and laboratory studies of disease mechanisms were the prevailing types of research about H. pylori. Comparatively few therapeutic intervention studies were done; this fact may have hampered the acceptance......OBJECTIVES: To describe the medical research process from the time of the generation of a new theory to its implementation in clinical practice. The Helicobacter pylori (H. pylori) theory, i.e. the theory that H. pylori plays a significant causal role in duodenal ulcer disease was chosen as a case....... MATERIAL: Abstracts from 1984 to 1993, identified in the CD-Rom, Medline system, ("Silverplatter"), using the search terms Campylobacter pylori and Helicobacter pylori, and reviews and editorials about H. pylori in some of the most widespread clinical journals. RESULTS: 2204 papers on H. pylori were...

  11. THE EVALUATION OF FREQUENCY AND SEASONAL VARIATIONS OF ACID PEPTIC DISEASE: A SEVEN YEARS STUDY

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    Syed Iftikhar Haider

    2016-06-01

    Full Text Available Acid peptic disease (APD is a worldwide health problem. It includes a variety of inflammatory and ulcerative lesions involving esophagus, stomach and duodenum. The disease condition may persist with multiple symptoms, one of them being dyspepsia. The object of the present study was to determine the frequency and seasonal variations of APD in patients presenting with dyspeptic symptoms. This observational study was carried out at the endoscopy unit in Baqai Medical University from December 2003 to December 2010, over a period of seven years. The evolution of APD frequency remained equivocal throughout the study period. However, a decline was noted in the frequency of peptic ulcer disease (PUD especially for gastric and duodenal ulcer cases but a rise during autumn and winter seasons was also noted in duodenal ulcer cases.

  12. The Need for Total Hip Arthroplasty in Perthes Disease: A Long-term Study

    DEFF Research Database (Denmark)

    Froberg, Lonnie; Christensen, Finn; Pedersen, Niels Wisbech

    2010-01-01

    BACKGROUND: Legg-Calvé-Perthes disease (LCPD) was described a century ago. In previous long-term reports of patients with LCPD, nonoperative treatment varied considerably. The likelihood of hip osteoarthritis (OA) developing in patients with LCPD and possible need for THA are not well defined...... with hips with Classes I/II femoral heads. PATIENTS AND METHODS: The study population consisted of 167 patients with LCPD treated with a Thomas splint. The control population consisted of gender- and age-matched control subjects who were participants in the Copenhagen City Heart Study: the Osteoarthritis...... OF EVIDENCE: Level III, prognostic study. See Guidelines for Authors for a complete description of levels of evidence....

  13. Risk Factors of Congenital Heart Diseases: A Case-Control Study inNorthwest Iran.

    Science.gov (United States)

    Naghavi-Behzad, Mohammad; Alizadeh, Mahasti; Azami, Saber; Foroughifar, Shirin; Ghasempour-Dabbaghi, Khazar; Karzad, Nazila; Ahadi, Hamid-Reza; Naghavi-Behzad, Ali

    2013-01-01

    Congenital heart diseases are of immense importance and also a high prevalence. Contributing factors to developing these defects have not been abundantly studied. Therefore, the current study was conducted aiming at determining the effective factors on Congenital Heart Disease (CHD) in newborn infants of Northwest Iran. A case-control study was carried out in North-West of Iran from 2002 to 2012 and a total of 473 infants entered the study. Required data were obtained through check lists completed by the information of hospital records and interview with mothers of 267 newborn infants with CHD together with medical records of mothers as the case group, and 206 medical records of healthy infants at the same period all together with those of their mothers as the control group. The obtained data were statistically analyzed using descriptive statistical methods, T-test, Spearman's correlation coefficient, and Multi-variable Logistic Regression Model (OR with 95% CI), using SPSS.19. In the present study, P value less than 0.05 was considered statistically significant. Based on the results of univariable analyses, the number of previous cesarean sections, past medical history of diseases, gestational age (GA), fetal weight at birth, diastolic blood pressure, fetal heart rate, pulse rate, fetal hemoglobin and hematocrit levels, and fetal head circumference at birth have significant relationship with incidence of congenital abnormalities (Prelationship with CHD incidence. Based on the results of present study, in order to control and reduce the cases of CHD, it is crucial to make proper decisions and implement policies for reducing cesarean cases, lowering consanguineous marriages, providing proper pre-marriage counseling, prompt treatment of mothers' illnesses, improving pregnancy health care and mothers' health status for the purpose of better well-being of newborn infants.

  14. Risk Factors of Congenital Heart Diseases: A Case-Control Study in Northwest Iran

    Directory of Open Access Journals (Sweden)

    Naghavi-Behzad Mohammad

    2013-03-01

    Full Text Available Introduction: Congenital heart diseases are of immense importance and also a high prevalence. Contributing factors to developing these defects have not been abundantly studied. Therefore, the current study was conducted aiming at determining the effective factors on Congenital Heart Disease (CHD in newborn infants of Northwest Iran. Methods: A case-control study was carried out in North-West of Iran from 2002 to 2012 and a total of 473 infants entered the study. Required data were obtained through check lists completed by the information of hospital records and interview with mothers of 267 newborn infants with CHD together with medical records of mothers as the case group, and 206 medical records of healthy infants at the same period all together with those of their mothers as the control group. The obtained data were statistically analyzed using descriptive statistical methods, T-test, Spearman’s correlation coefficient, and Multi-variable Logistic Regression Model (OR with 95% CI, using SPSS.19. In the present study, P value less than 0.05 was considered statistically significant. Results: Based on the results of univariable analyses, the number of previous cesarean sections, past medical history of diseases, gestational age (GA, fetal weight at birth, diastolic blood pressure, fetal heart rate, pulse rate, fetal hemoglobin and hematocrit levels, and fetal head circumference at birth have significant relationship with incidence of congenital abnormalities (P<0.05. Family history, past cesarean sections history, past medical history and GA had significant relationship with CHD incidence. Conclusion: Based on the results of present study, in order to control and reduce the cases of CHD, it is crucial to make proper decisions and implement policies for reducing cesarean cases, lowering consanguineous marriages, providing proper pre-marriage counseling, prompt treatment of mothers’ illnesses, improving pregnancy health care and mothers

  15. Cardiovascular events in patients with atherothrombotic disease: a population-based longitudinal study in Taiwan.

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    Wen-Hsien Lee

    Full Text Available BACKGROUND: Atherothrombotic diseases including cerebrovascular disease (CVD, coronary artery disease (CAD, and peripheral arterial disease (PAD, contribute to the major causes of death in the world. Although several studies showed the association between polyvascular disease and poor cardiovascular (CV outcomes in Asian population, there was no large-scale study to validate this relationship in this population. METHODS AND RESULTS: This retrospective cohort study included patients with a diagnosis of CVD, CAD, or PAD from the database contained in the Taiwan National Health Insurance Bureau during 2001-2004. A total of 19954 patients were enrolled in this study. The atherothrombotic disease score was defined according to the number of atherothrombotic disease. The study endpoints included acute coronary syndrome (ACS, all strokes, vascular procedures, in hospital mortality, and so on. The event rate of ischemic stroke (18.2% was higher than that of acute myocardial infarction (5.7% in our patients (P = 0.0006. In the multivariate Cox regression analyses, the adjusted hazard ratios (HRs of each increment of atherothrombotic disease score in predicting ACS, all strokes, vascular procedures, and in hospital mortality were 1.41, 1.66, 1.30, and 1.14, respectively (P≦0.0169. CONCLUSIONS: This large population-based longitudinal study in patients with atherothrombotic disease demonstrated the risk of subsequent ischemic stroke was higher than that of subsequent AMI. In addition, the subsequent adverse CV events including ACS, all stroke, vascular procedures, and in hospital mortality were progressively increased as the increase of atherothrombotic disease score.

  16. Nanomedicine for Inner Ear Diseases: A Review of Recent In Vivo Studies

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    Dong-Kee Kim

    2017-01-01

    Full Text Available Nanoparticles are promising therapeutic options for inner ear disease. In this report, we review in vivo animal studies in the otologic field using nanoparticles over the past 5 years. Many studies have used nanoparticles to deliver drugs, genes, and growth factors, and functional and morphological changes have been observed. The constituents of nanoparticles are also diversifying into various biocompatible materials, including poly(lactic-co-glycolic acid (PLGA. The safe and effective delivery of drugs or genes in the inner ear will be a breakthrough for the treatment of inner ear diseases, including age-related hearing loss.

  17. Striatal dopamine in Parkinson disease: A meta-analysis of imaging studies.

    Science.gov (United States)

    Kaasinen, Valtteri; Vahlberg, Tero

    2017-12-01

    A meta-analysis of 142 positron emission tomography and single photon emission computed tomography studies that have investigated striatal presynaptic dopamine function in Parkinson disease (PD) was performed. Subregional estimates of striatal dopamine metabolism are presented. The aromatic L-amino-acid decarboxylase (AADC) defect appears to be consistently smaller than the dopamine transporter and vesicular monoamine transporter 2 defects, suggesting upregulation of AADC function in PD. The correlation between disease severity and dopamine loss appears linear, but the majority of longitudinal studies point to a negative exponential progression pattern of dopamine loss in PD. Ann Neurol 2017;82:873-882. © 2017 American Neurological Association.

  18. Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study

    DEFF Research Database (Denmark)

    Håkansson, Kåre; von Buchwald, Christian; Thomsen, Simon F

    2011-01-01

    The cause of nonallergic rhinitis (NAR) and its relation to lower airway disease remains unclear. The purpose of this study was to perform a descriptive analysis of the occurrence of rhinitis in a Danish general population with focus on NAR and its association with smoking and lower airway disease....

  19. The association between periodontal disease and chronic obstructive pulmonary disease: a case control study.

    Science.gov (United States)

    Öztekin, Görkem; Baser, Ulku; Kucukcoskun, Meric; Tanrikulu-Kucuk, Sevda; Ademoglu, Evin; Isik, Gulden; Ozkan, Gulcihan; Yalcin, Funda; Kiyan, Esen

    2014-08-01

    Although there are studies evaluating the effects of periodontal health on chronic obstructive pulmonary disease (COPD), the effects of COPD - a systemic disease, on periodontal tissue is unknown. The aim of this study is to evaluate the effects of COPD on periodontal tissues by comparing COPD patients and controls. Fifty-two COPD patients and 38 non-COPD controls were included in this case-control study. Number of teeth, plaque index (PI), gingival index (GI), bleeding on probing, clinical attachment level and probing depth were included in the periodontal examination. In addition to clinical evaluations, gingival crevicular fluid (GCF) levels of high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-lb) and prostaglandin-E2 (PGE2), and serum hs-CRP levels were measured in COPD patients and the controls. The number of teeth was significantly lower while PI and GI were significantly higher in COPD patients when compared to the controls. As well as serum hs-CRP levels, the GCF levels of hs-CRP, IL-1b and PGE2 were significantly higher in COPD patients than the controls. Our results demonstrated that COPD may be associated with periodontal disease as manifested by lower number of teeth and higher levels of inflammatory mediators especially CRP in GCF. This finding may be a reflection of systemic effects of COPD on periodontal tissues. Poor oral health behavior of COPD patients have to be considered in larger size group studies in the future.

  20. Estrogen use and early onset Alzheimer's disease: a population-based study

    NARCIS (Netherlands)

    A.J.C. Slooter (Arjen); J.B. Bronzova (Juliana); J.C.M. Witteman (Jacqueline); C.M. van Duijn (Cornelia); C. van Broeckhoven (Christine); A. Hofman (Albert)

    1999-01-01

    textabstractEstrogen use may be protective for Alzheimer's disease with late onset. However, the effects on early onset Alzheimer's disease are unclear. This issue was studied in a population based setting. For each female patient, a female control was matched on age (within 5

  1. Adipokines as Possible New Predictors of Cardiovascular Diseases: A Case Control Study

    Directory of Open Access Journals (Sweden)

    Laura Pala

    2012-01-01

    Full Text Available Background and Aims. The secretion of several adipocytokines, such as adiponectin, retinol-binding protein 4 (RBP4, adipocyte fatty acid binding protein (aFABP, and visfatin, is altered in subjects with abdominal adiposity; these endocrine alterations could contribute to increased cardiovascular risk. The aim of the study was to assess the relationship among adiponectin, RBP4, aFABP, and visfatin, and incident cardiovascular disease. Methods and Results. A case-control study, nested within a prospective cohort, on 2945 subjects enrolled for a diabetes screening program was performed. We studied 18 patients with incident fatal or nonfatal IHD (Ischemic Heart Disease or CVD (Cerebrovascular Disease, compared with 18 matched control subjects. Circulating adiponectin levels were significantly lower in cases of IHD with respect to controls. Circulating RBP4 levels were significantly increased in CVD and decreased in IHD with respect to controls. Circulating aFABP4 levels were significantly increased in CVD, while no difference was associated with IHD. Circulating visfatin levels were significantly lower in cases of both CVD and IHD with respect to controls, while no difference was associated with CVD. Conclusions. The present study confirms that low adiponectin is associated with increased incidents of IHD, but not CVD, and suggests, for the first time, a major effect of visfatin, aFABP, and RBP4 in the development of cardiovascular disease.

  2. Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study

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    Matilde Zamboni

    2017-07-01

    Full Text Available Crohn’s disease (CD is a chronic inflammatory bowel disease and its pathogenesis is still not well understood. Previous studies suggested the possibility of the involvement of vascular system, but, todate, the mesenteric circulation has poor been investigated, especially in complicated CD cases requiring colectomy. We investigated the mesenteric circulation in a case-control pilot study, including 19 controls and 7 patients affected by complicated cases of CD. Cases and controls underwent selective angiography of both superior and inferior mesenteric district. Transit time was found either significantly shortened in 2/7 cases (29%, or prolonged 5/7 (71% (P=0.0034 in the superior mesenteric district; P=0.0079 in the inferior mesenteric district, respectively due to the presence of A-V malformations and of a miscellaneous of venous abnormalities, which included thrombosis, hypoplasia and extra-truncular venous malformations. Our study demonstrates the presence of congenital or acquired vascular anomalies in a small sample of CD patients not responder to current treatment and with severe complications. The present pilot study warrants further investigations.

  3. Diagnostic dilemmas in Fabry disease: a case series study on GLA mutations of unknown clinical significance

    NARCIS (Netherlands)

    Smid, B.E.; Hollak, C.E.M.; Poorthuis, B.J.H.M.; Bergh-Weerman, M.A. van den; Florquin, S.; Kok, W.E.; Deprez, R.H.L.; Timmermans, J.; Linthorst, G.E.

    2015-01-01

    Fabry disease' (FD) phenotype is heterogeneous: alpha-galactosidase A gene mutations (GLA) can lead to classical or non-classical FD, or no FD. The aim of this study is to describe pitfalls in diagnosing non-classical FD and assess the diagnostic value of plasma globotriaosylsphingosine. This is a

  4. Leptospira Exposure and Patients with Liver Diseases: A Case-Control Seroprevalence Study

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Sánchez-Anguiano, Luis Francisco; Hernández-Tinoco, Jesús; Ramos-Nevárez, Agar; Margarita Cerrillo-Soto, Sandra; Alberto Guido-Arreola, Carlos

    2016-01-01

    The seroepidemiology of Leptospira infection in patients suffering from liver disease has been poorly studied. Information about risk factors associated with infection in liver disease patients may help in the optimal planning of preventive measures. We sought to determine the association of Leptospira IgG seroprevalence and patients with liver diseases, and to determine the characteristics of the patients with Leptospira exposure. We performed a case-control study of 75 patients suffering from liver diseases and 150 age- and gender-matched control subjects. Diagnoses of liver disease included liver cirrhosis, steatosis, chronic hepatitis, acute hepatitis, and amoebic liver abscess. Sera of participants were analyzed for the presence of anti- Leptospira IgG antibodies using a commercially available enzyme immunoassay. Anti-Leptospira IgG antibodies were found in 17 (22.7%) of 75 patients and in 15 (10.0%) of 150 control subjects (OR = 2.32; 95% CI: 1.09-4.94; P=0.03). This is the first age- and gender-matched case control study about Leptospira seroprevalence in patients with liver diseases. Results indicate that Leptospira infection is associated with chronic and acute liver diseases. Results warrants for additional studies on the role of Leptospira exposure in chronic liver disease. PMID:27493589

  5. Increased cerebral iron uptake in Wilson's disease : A (52)Fe-citrate PET study

    NARCIS (Netherlands)

    Bruehlmeier, M; Leenders, KL; Vontobel, P; Calonder, C; Antonini, A; Weindl, A

    Toxicity of abundant copper is the main cause of brain and liver tissue damage in patients with Wilson's disease (WD). However, there is also evidence of a disturbed iron metabolism in this genetically determined disorder. This PET study was undertaken to assess cerebral iron metabolism in WD

  6. Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study

    Directory of Open Access Journals (Sweden)

    Nabil P

    2006-01-01

    Full Text Available Background: Abnormalities of the nail unit are common in patients with connective tissue diseases. Clinical examination of the nail unit, coupled with biopsy of proximal nail fold offers an additional advantage in the diagnosis. Purpose: Our aim was to record clinical changes of the nail unit in connective tissue diseases and to study the histopathological (both H and E and periodic acid Schiff and direct immunofluorescence (DIF findings of nail-fold biopsy. Materials and Methods: Thirty-eight confirmed cases connective tissue diseases attending skin OPD were enrolled in the study. After detailed clinical examination of the nail unit, a crescentric biopsy was taken from the proximal nail fold (PNF. Histopathological and DIF studies were was carried out. Findings: Nail changes could be demonstrated in 65% connective tissue diseases. Specific histopathological (H and E and immunofluorescence findings were also encountered in many patients. Conclusion: Clinical examination of the nail unit offers additional clue in the diagnosis of connective tissue diseases. Though DIF of PNF biopsy is useful in the diagnosis, it is not an ideal site for H and E study, as the yield is very low. Limitations: Lack of adequate comparison group and non-utilization of capillary microscopy for the detection of nail fold capillary abnormalities.

  7. Risk of cardiovascular disease? A qualitative study of risk interpretation among patients with high cholesterol

    DEFF Research Database (Denmark)

    Kirkegaard, P.; Edwards, A.; Risor, M. B.

    2013-01-01

    Background: Previous studies have shown the importance of paying attention to lay peoples' interpretations of risk of disease, in order to explain health-related behavior. However, risk interpretations interplay with social context in complex ways. The objective was to explore how asymptomatic...

  8. Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study

    DEFF Research Database (Denmark)

    Harboe, Zitta B; Thomsen, Reimar W; Riis, Anders

    2009-01-01

    BACKGROUND: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). METHODS AND FINDINGS: In a nationwide population-based...

  9. Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study

    NARCIS (Netherlands)

    Holmes, Michael V.; Simon, Tabassome; Exeter, Holly J.; Folkersen, Lasse; Asselbergs, Folkert W.; Guardiola, Montse; Cooper, Jackie A.; Palmen, Jutta; Hubacek, Jaroslav A.; Carruthers, Kathryn F.; Horne, Benjamin D.; Brunisholz, Kimberly D.; Mega, Jessica L.; van Iperen, Erik P. A.; Li, Mingyao; Leusink, Maarten; Trompet, Stella; Verschuren, Jeffrey J. W.; Hovingh, G. Kees; Dehghan, Abbas; Nelson, Christopher P.; Kotti, Salma; Danchin, Nicolas; Scholz, Markus; Haase, Christiane L.; Rothenbacher, Dietrich; Swerdlow, Daniel I.; Kuchenbaecker, Karoline B.; Staines-Urias, Eleonora; Goel, Anuj; van 't Hooft, Ferdinand; Gertow, Karl; de Faire, Ulf; Panayiotou, Andrie G.; Tremoli, Elena; Baldassarre, Damiano; Veglia, Fabrizio; Holdt, Lesca M.; Beutner, Frank; Gansevoort, Ron T.; Navis, Gerjan J.; Mateo Leach, Irene; Breitling, Lutz P.; Brenner, Hermann; Thiery, Joachim; Dallmeier, Dhayana; Franco-Cereceda, Anders; Boer, Jolanda M. A.; Stephens, Jeffrey W.; Hofker, Marten H.; Tedgui, Alain; Hofman, Albert; Uitterlinden, André G.; Adamkova, Vera; Pitha, Jan; Onland-Moret, N. Charlotte; Cramer, Maarten J.; Nathoe, Hendrik M.; Spiering, Wilko; Klungel, Olaf H.; Kumari, Meena; Whincup, Peter H.; Morrow, David A.; Braund, Peter S.; Hall, Alistair S.; Olsson, Anders G.; Doevendans, Pieter A.; Trip, Mieke D.; Tobin, Martin D.; Hamsten, Anders; Watkins, Hugh; Koenig, Wolfgang; Nicolaides, Andrew N.; Teupser, Daniel; Day, Ian N. M.; Carlquist, John F.; Gaunt, Tom R.; Ford, Ian; Sattar, Naveed; Tsimikas, Sotirios; Schwartz, Gregory G.; Lawlor, Debbie A.; Morris, Richard W.; Sandhu, Manjinder S.; Poledne, Rudolf; Maitland-van der Zee, Anke H.; Khaw, Kay-Tee; Keating, Brendan J.; van der Harst, Pim; Price, Jackie F.; Mehta, Shamir R.; Yusuf, Salim; Witteman, Jaqueline C. M.; Franco, Oscar H.; Jukema, J. Wouter; de Knijff, Peter; Tybjaerg-Hansen, Anne; Rader, Daniel J.; Farrall, Martin; Samani, Nilesh J.; Kivimaki, Mika; Fox, Keith A. A.; Humphries, Steve E.; Anderson, Jeffrey L.; Boekholdt, S. Matthijs; Palmer, Tom M.; Eriksson, Per; Paré, Guillaume; Hingorani, Aroon D.; Sabatine, Marc S.; Mallat, Ziad; Casas, Juan P.; Talmud, Philippa J.

    2013-01-01

    This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease. Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is

  10. Screening rules for growth to detect celiac disease : A case-control simulation study

    NARCIS (Netherlands)

    Dommelen, P. van; Grote, F.K.; Oostdijk, W.; Muinck Keizer de; Schrama, S.M.P.F.; Boersma, B.; Damen, G.M.; Csizmadia, C.G.; Verkerk, P.H.; Wit, J.M.; Buuren, S. van

    2008-01-01

    Background: It is generally assumed that most patients with celiac disease (CD) have a slowed growth in terms of length (or height) and weight. However, the effectiveness of slowed growth as a tool for identifying children with CD is unknown. Our aim is to study the diagnostic efficiency of several

  11. Risk factors for Creutzfeldt-Jakob disease: a reanalysis of case-control studies.

    NARCIS (Netherlands)

    D.P.W.M. Wientjens (Dorothee); Z. Davanipour; K. Kondo; W.B. Matthews; R.G. Will (Robert); C.M. van Duijn (Cornelia); A. Hofman (Albert)

    1996-01-01

    textabstractTo review the evidence for risk factors of Creutzfeldt-Jakob disease (CJD), we pooled and reanalyzed the raw data of three case-control studies. The pooled data set comprised 178 patients and 333 control subjects. The strength of association between CJD and putative risk factors was

  12. Coffee, caffeine-related genes, and Parkinson's disease: a case-control study.

    Science.gov (United States)

    Facheris, Maurizio F; Schneider, Nicole K; Lesnick, Timothy G; de Andrade, Mariza; Cunningham, Julie M; Rocca, Walter A; Maraganore, Demetrius M

    2008-10-30

    An inverse association between coffee and Parkinson's disease (PD) has been reported. However, it remains uncertain why some but not all coffee drinkers are less susceptible to PD. We considered the possibility of a pharmacogenetic effect. In our study, we included 1,208 subjects (446 case-unaffected sibling pairs and 158 case-unrelated control pairs) recruited from an ongoing study of the molecular epidemiology of PD in the Upper Midwest (USA). We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551). We did not observe significant associations of coffee drinking or of the genetic variants with PD susceptibility, either independently or jointly, in the sample overall and in most strata. Our study neither supports the hypothesis that coffee protects against PD nor provides evidence for a pharmacogenetic effect. (c) 2008 Movement Disorder Society.

  13. Coffee, Caffeine-Related Genes, and Parkinson's Disease: A Case–Control Study

    Science.gov (United States)

    Facheris, Maurizio F.; Schneider, Nicole K.; Lesnick, Timothy G.; de Andrade, Mariza; Cunningham, Julie M.; Rocca, Walter A.; Maraganore, Demetrius M.

    2015-01-01

    An inverse association between coffee and Parkinson's disease (PD) has been reported. However, it remains uncertain why some but not all coffee drinkers are less susceptible to PD. We considered the possibility of a pharmaco-genetic effect. In our study, we included 1,208 subjects (446 case-unaffected sibling pairs and 158 case-unrelated control pairs) recruited from an ongoing study of the molecular epidemiology of PD in the Upper Midwest (USA). We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551). We did not observe significant associations of coffee drinking or of the genetic variants with PD susceptibility, either independently or jointly, in the sample overall and in most strata. Our study neither supports the hypothesis that coffee protects against PD nor provides evidence for a pharmacogenetic effect. PMID:18759349

  14. Ostomy creation with fewer sutures using tissue adhesives (cyanoacrylates) in inflammatory bowel disease: a pilot study.

    Science.gov (United States)

    Uchino, M; Ikeuchi, H; Bando, T; Sasaki, H; Chohno, T; Horio, Y; Takesue, Y

    2018-03-01

    Introduction Fistula formation around the ostomy site is a stoma-related complication often requiring surgical intervention. This complication may be caused by sutures or may develop as a complication of inflammatory bowel disease. Before conducting a clinical trial, we set out to investigate the safety of ostomy creation with fewer sutures using tissue adhesives in this pilot study. Methods Patients with inflammatory bowel disease who required surgery with ostomy creation at the Hyogo College of Medicine between January 2014 and December 2015 were enrolled. Safety was assessed by evaluating the incidence of stoma-related complications. Ostomy was restricted to loop ileostomy and was created with two sutures and tissue adhesives. Results A total of 14 patients were enrolled. Mean body mass index was 18.9 ± 2.0 kg/m 2 . There were no cases of ostomy retraction and no severe adverse events were observed. Conclusions This pilot study demonstrates that ostomy creation using tissue adhesives is safe. Although retraction and adverse events were not observed, even in patients with inflammatory bowel disease who generally exhibit delayed wound healing, the body mass index was extremely low in this series. This study does not strongly recommend ostomy creation with tissue adhesives; further studies are needed to clarify the efficacy and safety of the procedure.

  15. Thyroid Autoantibodies and the Clinical Presentation of Moyamoya Disease: A Prospective Study.

    Science.gov (United States)

    Lanterna, Luigi A; Galliani, Silvia; Zangari, Rosalia; Conti, Luciano; Brembilla, Carlo; Gritti, Paolo; Colleoni, Maria Luisa; Bernucci, Claudio

    2018-05-01

    Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never been studied. The objective of this study was to investigate the relationship between thyroid autoantibodies and the clinical presentation of moyamoya. This is a prospective study including 37 patients with moyamoya disease (MMD) or unilateral moyamoya (uMM). Thyroid function and thyroid autoantibodies (e.g., antithyroperoxidase and antithyroglobulin) were investigated. We studied the effect of gender, age, type of moyamoya (uMM versus MMD), and thyroid autoantibodies on the clinical presentation, dichotomized into aggressive (hemorrhage, major stroke, or frequent transient ischemic attack [TIA]) and nonaggressive presentation (headache, rare TIAs, and incidental diagnosis) according to the criteria of the Research Committee on Spontaneous Occlusion of the Circle of Willis. Of the 37 patients included in the study, the autoantibodies were elevated in 9 (24.3%). An aggressive presentation occurred in 21 patients (hemorrhage in 11, major stroke in 9, frequent TIAs in 1). The autoantibodies were elevated in 8 of the 21 patients (38.09%) with an aggressive presentation and in 1 of those presenting with minor symptoms (6.2%). The presence of elevated autoantibodies was the only variable associated with an aggressive presentation in the multivariate logistic analysis (P = .048). When the serum concentration of the thyroid autoantibodies is increased, the patients have a higher risk of an aggressive presentation. Our results support the hypothesis that activation of immune-mediated processes affects the moyamoya physiopathology. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  16. A Prospective Trial of Ayurveda for Coronary Heart Disease: A Pilot Study.

    Science.gov (United States)

    DuBroff, Robert; Lad, Vasant; Murray-Krezan, Cristina

    2015-01-01

    Coronary heart disease is the leading cause of death worldwide, and its incidence is rapidly accelerating in developing nations. Patients often search for therapies that are alternatives to traditional treatments, such as heart medicines, coronary bypass surgery, or coronary stenting. Ayurveda is an ancient, East Indian, holistic approach to health care, and its use has never been formally evaluated for patients with coronary heart disease. The study intended to examine the feasibility and effectiveness of comprehensive ayurvedic therapy-incorporating diet, meditation, breathing exercises, yoga, and herbs-for patients with established coronary heart disease. The study was a prospective, single-group, pilot study. The study took place at the University of New Mexico Cardiology Clinic and at the Ayurvedic Institute in Albuquerque, NM, USA. The participants were adults with a history of a prior heart attack, coronary bypass surgery, or a coronary intervention (ie, a coronary angioplasty and/or stent). All enrolled patients were evaluated by a single ayurvedic physician with >40 y of experience, and each received therapy consisting of a calorically unrestricted ayurvedic diet; instruction in yoga, meditation, and breathing; and use of ayurvedic herbs. The primary endpoint was arterial pulse wave velocity, a marker of arterial function and vascular health. Secondary endpoints included the following measurements: (1) body mass index (BMI); (2) blood pressure (BP) and amount of reduction in BP medications; and (3) levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. All parameters were measured at baseline and after 90 d of therapy. Twenty-two patients were enrolled in the study, and 19 patients completed it. The research team observed significant improvements in arterial pulse wave velocity (P = .015), and favorable reductions in BMI (P ayurveda on arterial function and multiple risk

  17. Relationship Between Prehypertension/Hypertension and Periodontal Disease: A Prospective Cohort Study.

    Science.gov (United States)

    Kawabata, Yuya; Ekuni, Daisuke; Miyai, Hisataka; Kataoka, Kota; Yamane, Mayu; Mizutani, Shinsuke; Irie, Koichiro; Azuma, Tetsuji; Tomofuji, Takaaki; Iwasaki, Yoshiaki; Morita, Manabu

    2016-03-01

    Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students. Students (n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and community periodontal index (CPI) scores, and change in blood pressure status was determined. At the reexamination, the numbers of participants with prehypertension (systolic blood pressure 120-139mm Hg or diastolic blood pressure 80-89mm Hg) and hypertension (≥140/90mm Hg) were 882 (34.1%) and 109 (4.2%), respectively. In a logistic regression model, the risk of hypertension was significantly associated with male (odds ratio (OR): 6.31; 95% confidence interval (CI): 2.63-15.13; P periodontal disease defined as the presence of both probing pocket depth (PPD) ≥ 4mm and BOP ≥ 30% at baseline (OR: 2.74; 95% CI: 1.19-6.29; P = 0.02) in participants with prehypertension at baseline. On the other hand, the risk of prehypertension was not associated with presence of periodontal disease (OR: 0.93; 95% CI: 0.51-1.70; P = 0.82). In the short-term prospective cohort study, a significant association between presence of periodontal disease and hypertension was observed in Japanese university students. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study.

    Directory of Open Access Journals (Sweden)

    Irene Pichler

    Full Text Available Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD, epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite directions. Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR represents an alternative approach to provide unconfounded estimates of the effects of biomarkers on disease. We performed a MR study where genes known to modify iron levels were used as instruments to estimate the effect of iron on PD risk, based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date.We used as instrumental variables three genetic variants influencing iron levels, HFE rs1800562, HFE rs1799945, and TMPRSS6 rs855791. Estimates of their effect on serum iron were based on a recent genome-wide meta-analysis of 21,567 individuals, while estimates of their effect on PD risk were obtained through meta-analysis of genome-wide and candidate gene studies with 20,809 PD cases and 88,892 controls. Separate MR estimates of the effect of iron on PD were obtained for each variant and pooled by meta-analysis. We investigated heterogeneity across the three estimates as an indication of possible pleiotropy and found no evidence of it. The combined MR estimate showed a statistically significant protective effect of iron, with a relative risk reduction for PD of 3% (95% CI 1%-6%; p = 0.001 per 10 µg/dl increase in serum iron.Our study suggests that increased iron levels are causally associated with a decreased risk of developing PD. Further studies are needed to understand the pathophysiological mechanism of action of serum iron on PD risk before recommendations can be made.

  19. Nuclear research reactor IEA-R1 heat exchanger inlet nozzle flow - a preliminary study

    International Nuclear Information System (INIS)

    Angelo, Gabriel; Andrade, Delvonei Alves de; Fainer, Gerson; Angelo, Edvaldo

    2009-01-01

    As a computational fluid mechanics training task, a preliminary model was developed. ANSYS-CFX R code was used in order to study the flow at the inlet nozzle of the heat exchanger of the primary circuit of the nuclear research reactor IEA-R1. The geometry of the inlet nozzle is basically compounded by a cylinder and two radial rings which are welded on the shell. When doing so there is an offset between the holes through the shell and the inlet nozzle. Since it is not standardized by TEMA, the inlet nozzle was chosen for a preliminary study of the flow. Results for the proposed model are presented and discussed. (author)

  20. Purification, crystallization and preliminary X-ray diffraction studies of parakeet (Psittacula krameri) haemoglobin.

    Science.gov (United States)

    Jaimohan, S M; Naresh, M D; Arumugam, V; Mandal, A B

    2009-10-01

    Birds often show efficient oxygen management in order to meet the special demands of their metabolism. However, the structural studies of avian haemoglobins (Hbs) are inadequate for complete understanding of the mechanism involved. Towards this end, purification, crystallization and preliminary X-ray diffraction studies have been carried out for parakeet Hb. Parakeet Hb was crystallized as the met form in low-salt buffered conditions after extracting haemoglobin from crude blood by microcentrifugation and purifying the sample by column chromatography. Good-quality crystals were grown from 10% PEG 3350 and a crystal diffracted to about 2.8 A resolution. Preliminary diffraction data showed that the Hb crystal belonged to the monoclinic system (space group C2), with unit-cell parameters a = 110.68, b = 64.27, c = 56.40 A, beta = 109.35 degrees . Matthews volume analysis indicated that the crystals contained a half-tetramer in the asymmetric unit.

  1. Associations between Obesity and Spinal Diseases: A Medical Expenditure Panel Study Analysis

    Directory of Open Access Journals (Sweden)

    Binwu Sheng

    2017-02-01

    Full Text Available Background: The link between body weight status and spinal diseases has been suggested by a number of cross-sectional and cohort studies with a limited range of patient populations. No population-representative samples have been used to examine the link between obesity and spinal diseases. The present study is based on a nationally representative sample drawn from the Medical Expenditure Panel Survey. Methods: Using the cross-sectional sample of the 2014 Medical Expenditure Panel Study, we built four weighted logistic regression analyses of the associations between body weight status and the following four spinal diseases: low back pain, spondylosis, other cervical disorders and intervertebral disc disorder (IDD. Each respondent’s body weight status was used as the key independent variable with three categories: normal/underweight, overweight, and obese. We controlled for marital status, gender, age, smoking status, household income, health insurance coverage, educational attainment and the use of health services for other major categories of diseases. Results: A total sample of 23,048 respondents was used in our analysis. Overweight and obese respondents, as compared to normal/underweight respondents, were more likely to develop lower back problems (Overweight: logged odds = 0.218, p < 0.01; Obese: logged odds = 0.395, p < 0.001 and IDD (Overweight: logged odds = 0.441, p < 0.05; Obese: logged odds = 0.528, p < 0.001. The associations between bodyweight status and spondylitis were statistically insignificant (Overweight: logged odds = 0.281, p = 0.442; Obese: logged odds = 0.680, p = 0.104. The associations between body weight status and other cervical disorders (Overweight: logged odds = −0.116, p = 0.304; Obese: logged odds = −0.160, p = 0.865 were statistically insignificant. Conclusions: As the first study using a national sample to study bodyweight and spinal diseases, our paper supports the hypothesis that obesity adds to the burden

  2. In-home Telerehabilitation for Older Persons with Chronic Obstructive Pulmonary Disease: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Michel Tousignant

    2012-04-01

    Full Text Available The purpose of this pilot study was to investigate the efficacy of in-home telerehabilitation for people with Chronic Obstructive Pulmonary Disease (COPD. Three community-living elders with COPD were recruited in a rehabilitation outpatient group and by direct referrals from pneumologists with outpatients who have COPD. A pre/post-test design without a control group was used for this pilot study. Telerehabilitation sessions (15 sessions were conducted by two trained physio­therapists from a service center to the patient’s home. Locomotor function (walking performance and quality of life were measured in person prior to and at the end of the treatment by an independent assessor. Clinical outcomes improved for all subjects except for locomotor function in the first participant. In-home telerehabilitation for people with COPD is a realistic alternative to dispense rehabilitation services for patients requiring physical therapy follow-up. 

  3. The effect of long working hours on cerebrovascular and cardiovascular disease; A case-crossover study.

    Science.gov (United States)

    Shin, Kyong-Sok; Chung, Yun Kyung; Kwon, Young-Jun; Son, Jun-Seok; Lee, Se-Hoon

    2017-09-01

    This study investigated the relationship between weekly working hours and the occurrence of cerebro-cardiovascular diseases using a case-crossover study design. We investigated average working hours during the 7 days before the onset of illness (hazard period) and average weekly working hours between 8 days and 3 months before the onset of cerebro-cardiovascular diseases (control period) for 1,042 cases from the workers' compensation database for 2009. Among all subjects, the odds ratio by conditional logistic regression for the risk of cerebro-cardiovascular diseases with a 10 hr increase in average weekly working hours was 1.45 (95% confidence interval [CI]: 1.22-1.72), a significant association. An increase in average weekly working hours may trigger the onset of cerebro-cardiovascular disease. Am. J. Ind. Med. 60:753-761, 2017. © 2017. Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  4. Suicidal ideation in Chinese patients with chronic obstructive pulmonary disease: a controlled study.

    Science.gov (United States)

    Wong, Tak-Shun; Xiang, Yu-Tao; Tsoh, Joshua; Ungvari, Gabor S; Ko, Fanny W S; Hui, David S C; Chiu, Helen F K

    2016-05-01

    No study has been published on the prevalence of suicidal behaviour in older Chinese patients with chronic obstructive pulmonary disease (COPD). This study examined the 1-year prevalence of suicidal ideation in older Chinese COPD patients and explored its demographic and clinical correlates. A consecutive sample of 143 COPD patients and 211 matched control subjects were recruited and interviewed using structured, standardized instruments. The 1-year prevalence of suicidal ideation in COPD patients and controls were 15.4% and 10.9%, respectively. In multivariate analyses, suicidal ideation was significantly associated with the severity of depressive symptoms in COPD patients. Suicidal ideation was not higher in COPD patients than in controls. © 2015 The Authors. Psychogeriatrics © 2015 Japanese Psychogeriatric Society.

  5. Post-traumatic stress disorder and incidence of coronary heart disease: a twin study.

    Science.gov (United States)

    Vaccarino, Viola; Goldberg, Jack; Rooks, Cherie; Shah, Amit J; Veledar, Emir; Faber, Tracy L; Votaw, John R; Forsberg, Christopher W; Bremner, J Douglas

    2013-09-10

    The aim of this study was to determine whether post-traumatic stress disorder (PTSD) is associated with coronary heart disease (CHD) using a prospective twin study design and objective measures of CHD. It has long been hypothesized that PTSD increases the risk of CHD, but empirical evidence using objective measures is limited. We conducted a prospective study of middle-aged male twins from the Vietnam Era Twin Registry. Among twin pairs without self-reported CHD at baseline, we selected pairs discordant for a lifetime history of PTSD, pairs discordant for a lifetime history of major depression, and pairs without either condition. All underwent a clinic visit after a median follow-up of 13 years. Outcomes included clinical events (myocardial infarction, other hospitalizations for CHD and coronary revascularization) and quantitative measures of myocardial perfusion by [(13)N] ammonia positron emission tomography, including a stress total severity score and coronary flow reserve. A total of 562 twins (281 pairs) with a mean age of 42.6 years at baseline were included in this study. The incidence of CHD was more than double in twins with PTSD (22.6%) than in those without PTSD (8.9%; p Stress total severity score was significantly higher (+95%, p = 0.001) and coronary flow reserve was lower (-0.21, p = 0.02) in twins with PTSD than in those without PTSD, denoting worse myocardial perfusion. Associations were only mildly attenuated in 117 twin pairs discordant for PTSD. Among Vietnam-era veterans, PTSD is a risk factor for CHD. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  6. An epidemiological profile of chronic obstructive pulmonary disease: A community-based study in Delhi

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    B Sinha

    2017-01-01

    Full Text Available Background: Different definitions used for chronic obstructive pulmonary disease (COPD preclude getting reliable prevalence estimates. Study objective was to find the prevalence of COPD as per standard Global Initiative for Chronic Obstructive Lung Disease definition, risk factors associated, and treatment seeking in adults >30 years. Methodology: Community-based cross-sectional study was conducted in Delhi, among 1200 adults, selected by systematic random sampling. Pretested questionnaire was used to interview all subjects and screen for symptoms of COPD. Postbronchodilator spirometry was done to confirm COPD. Statistical Analysis: Adjusted odds ratio (aOR was calculated by multivariable analysis to examine the association of risk factors with COPD. Receiver operating characteristic (ROC curve was developed to assess predictability. Results: The prevalence of COPD was 10.1% (95% confidence interval [CI] 8.5, 11.9%. Tobacco smoking was the strongest risk factor associated (aOR 9.48; 95% CI 4.22, 14.13 followed by environmental tobacco smoke (ETS, occupational exposure, age, and biomass fuel. Each pack-year of smoking increased 15% risk of COPD. Ex-smokers had 63% lesser risk compared to current smokers. Clinical allergy seems to preclude COPD (aOR 0.06; 95% CI 0.02, 0.37. ROC analysis showed 94.38% of the COPD variability can be assessed by this model (sensitivity 57.4%; positive predictive value 93.3%. Only 48% patients were on treatment. Treatment continuation was impeded by its cost. Conclusion: COPD prevalence in the region of Delhi, India, is high, and our case-finding population study identified a high rate of patients who were not on any treatment. Our study adds to creating awareness on the importance of smoking cessation, early diagnosis of COPD, and the need for regular treatment.

  7. Risk of Unsuccessful Noninvasive Ventilation for Acute Respiratory Failure in Heterogeneous Neuromuscular Diseases: A Retrospective Study

    OpenAIRE

    Kataoka, Hiroshi; Nanaura, Hitoki; Kinugawa, Kaoru; Uchihara, Yuto; Ohara, Hiroya; Eura, Nobuyuki; Syobatake, Ryogo; Sawa, Nobuhiro; Takao, Kiriyama; Sugie, Kazuma; Ueno, Satoshi

    2017-01-01

    If invasive ventilation can be avoided by performing noninvasive mechanical ventilation (NIV) in patients with acute respiratory failure (ARF), the disease can be effectively managed. It is important to clarify the characteristics of patients with neuromuscular diseases in whom initial NIV is likely to be unsuccessful. We studied 27 patients in stable neuromuscular condition who initially received NIV to manage fatal ARF to identify differences in factors immediately before the onset of ARF a...

  8. Quality Of Life in Children with Celiac Disease: A Cross-sectional Study

    Directory of Open Access Journals (Sweden)

    Seyed Ali Jafari

    2017-07-01

    Full Text Available Background Celiac disease (CD is a systemic autoimmune disorder due to immune response triggered by ingestion of gluten in the diet. Treatment with lifelong gluten-free diet may impact negatively on the health-related quality of life and may lead to psychological disturbances. The purpose of study was to evaluate quality of life, depression and anxiety in children with celiac disease. Materials and Methods In this cross-sectional study was done between 2013 and 2014 at the Gastroenterology Outpatient Clinic (Ghaem Hospital, Mashhad- Iran, patients with serology and biopsy-proven CD, on a gluten-free diet for at least one year, were included in this study and compared with non-celiac healthy children as controls. We used the questionnaire to investigate quality of life, anxiety and depression. Results There were statistically significant differences between the mean total anxiety (state, trait scores and depression score in the celiac patients and control group. Correlations between state and trait anxiety and depression were statistically significant (P= 0.01, r= 0.35 and (P= 0.001, r= 0.52. Reverse correlations between quality of life of CD children and anxiety (state, trait were statistically significant (P= 0.001, r= 0.51 and P= 0.02, r= 0.32. Mean total score of quality of life was not different in the two groups, but in the physical activity component, quality of life was better in CD patients (P=0.008. Conclusion In current study, anxiety and depression had a significant impact on the course of celiac disease.

  9. Neuropsychiatric and cardiometabolic comorbidities in patients with previously diagnosed Cushing's disease: a longitudinal observational study

    OpenAIRE

    Dimopoulou, C; Geraedts, V; Stalla, G K; Sievers, C

    2015-01-01

    INTRODUCTION: Only few studies have systematically investigated neuropsychiatric aspects in patients with Cushing's disease (CD). Pain syndromes have been described in patients with pituitary adenomas, but so far no systematical investigation has been conducted in patients with CD. Additionally, CD has an association with cardiometabolic comorbidities which ultimately leads to increased morbidity and mortality. Long-term treatment of the hypercortisolic state cannot prevent the persistence of...

  10. Association between bullous pemphigoid and neurologic diseases: a case-control study.

    Science.gov (United States)

    Casas-de-la-Asunción, E; Ruano-Ruiz, J; Rodríguez-Martín, A M; Vélez García-Nieto, A; Moreno-Giménez, J C

    2014-11-01

    In the past 10 years, bullous pemphigoid has been associated with other comorbidities and neurologic and psychiatric conditions in particular. Case series, small case-control studies, and large population-based studies in different Asian populations, mainland Europe, and the United Kingdom have confirmed this association. However, no data are available for the Spanish population. This was an observational, retrospective, case-control study with 1:2 matching. Fifty-four patients with bullous pemphigoid were selected. We compared the percentage of patients in each group with concurrent neurologic conditions, ischemic heart disease, diabetes, chronic obstructive pulmonary disease, and solid tumors using univariate logistic regression. An association model was constructed with conditional multiple logistic regression. The case group had a significantly higher percentage of patients with cerebrovascular accident and/or transient ischemic attack (odds ratio [OR], 3.06; 95% CI, 1.19-7.87], dementia (OR, 5.52; 95% CI, 2.19-13.93), and Parkinson disease (OR, 5; 95% CI, 1.57-15.94). A significantly higher percentage of cases had neurologic conditions (OR, 6.34; 95% CI, 2.89-13.91). Dementia and Parkinson disease were independently associated with bullous pemphigoid in the multivariate analysis. Patients with bullous pemphigoid have a higher frequency of neurologic conditions. Copyright © 2013 Elsevier España, S.L.U. and AEDV. All rights reserved.

  11. Low doses of ionizing radiation and risk of cardiovascular disease: A review of epidemiological studies

    International Nuclear Information System (INIS)

    Metz-Flamant, C.; Bonaventure, A.; Tirmarche, M.; Laurier, D.; Bernier, M.O.; Milliat, F.

    2009-01-01

    Background While cardiovascular risks associated with high level of ionizing radiation are well-established, long-term effects of low and medium levels of exposure, between 0 and 5 gray (Gy), on the cardiovascular system are debated. Methods Available literature was reviewed considering various populations, such as survivors of atomic bombs, nuclear workers, Chernobyl liquidators, radiologists and radiological technologists and patients exposed for medical reasons. Results A significant increased risk of cardiovascular diseases associated with low doses of ionizing radiation was observed in 13 studies among the 27 analyzed. The ischemic heart diseases risk was detailed in 16 studies and seven of them showed a significant increase. The cerebrovascular risk was significantly increased in five studies among the 12 considered. Conclusion Some epidemiological and experimental data are clearly in favour of an increased cardiovascular risk associated with exposure to low doses. However, given the multi-factorial origin of cardiovascular diseases and the lack of a clear pathophysiologic mechanism, epidemiological results have to be carefully interpreted. Further research should be conducted in this area. (authors)

  12. Treadmill training improves overground walking economy in Parkinson’s disease: A randomized, controlled pilot study

    Directory of Open Access Journals (Sweden)

    Miguel eFERNANDEZ-DEL-OLMO

    2014-09-01

    Full Text Available Gait disturbances are one of the principal and most incapacitating symptoms of Parkinson’s disease (PD. In addition, walking economy is impaired in PD patients and could contribute to excess fatigue in this population. An important number of studies have shown that treadmill training can improve kinematic parameters in PD patients. However, the effects of treadmill and overground walking on the walking economy remain unknown. The goal of this study was to explore the walking economy changes in response to a treadmill and an overground training program, as well as the differences in the walking economy during treadmill and overground walking. 22 mild PD patients were randomly assigned to a treadmill or overground training group. The training program consisted of 5 weeks (3 sessions/week. We evaluated the energy expenditure of overground walking, before and after each of the training programs. The energy expenditure of treadmill walking (before the program was also evaluated. The treadmill, but not the overground training program, lead to an improvement in the walking economy (the rate of oxygen consumed per distance, during overground walking at a preferred speed in PD patients. In addition, walking on a treadmill required more energy expenditure compared with overground walking at the same speed. This study provides evidence that in mild PD patients, treadmill training is more beneficial compared with that of walking overground, leading to a greater improvement in the walking economy. This finding is of clinical importance for the therapeutic administration of exercise in Parkinson’s disease.

  13. Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study.

    Science.gov (United States)

    Siddarth, Manushi; Datta, Sudip K; Ahmed, Rafat S; Banerjee, Basu D; Kalra, Om P; Tripathi, Ashok K

    2013-07-01

    CYP1A1 is an important xenobiotic metabolizing enzyme, present in liver and kidney. Expression of CYP1A1 enzyme increases manifold when kidney cells are exposed to nephrotoxins/chemicals leading to oxidative stress-induced cell damage. To study the association of CYP1A1 gene polymorphism in patients of chronic kidney disease with unknown etiology (CKDU), we recruited 334 CKDU patients and 334 age and sex matched healthy controls. CYP1A1*2A and *2C polymorphisms were studied by PCR-RFLP and allele specific-PCR respectively. Subjects carrying at least one mutant allele of CYP1A1*2A (TC, CC) and *2C (AG, GG) were shown to be associated with 1.4-2-fold increased risk of CKDU. Also, genotypic combinations of hetero-/homozygous mutants of CYP1A1*2A (TC, CC) with hetero-/homozygous mutant genotypes of CYP1A1*2C (AG, GG) i.e. TC/AG (pCKDU with an odd ratio ranging 1.8-3.3 times approximately. This study demonstrates association of CYP1A1 polymorphisms with CKDU. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Effects of Ramadan fasting on moderate to severe chronic kidney disease. A prospective observational study.

    Science.gov (United States)

    Bakhit, Amaar A; Kurdi, Amr M; Wadera, Junaid J; Alsuwaida, Abdulkareem O

    2017-01-01

    To examin the effect of Ramadan fasting on worsening of renal function (WRF). Method: This was a single-arm prospective observational study including 65 patients with stage 3 or higher chronic kidney disease (CKD). By definition, WRF was considered to have occurred when serum creatinine levels increased by 0.3 mg/dL (26.5 µmol/l) from baseline during or within 3 months after Ramadan. The study was conducted in the Nephrology Clinic of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia during the month of Ramadan 1436 AH (Hijiri), which corresponded to June 18-July 17, 2015.  Results: This study included 65 adults with a mean age of 53 years. Overall, 33% of patients developed WRF. In the multivariate analysis, more advanced CKD stage, higher baseline systolic blood pressure and younger age were independently associated with WRF. Underlying cause of CKD, use of diuretics, use of renin angiotensin blockers, gender, and smoking status were not associated with WRF.  Conclusion: In patients with stage 3 or higher CKD, Ramadan fasting during the summer months was associated with worsening of renal function. Clinicians need to warn CKD patients against Ramadan fasting.

  15. Rheumatic heart disease- a study of surgically excised cardiac valves and biopsies

    International Nuclear Information System (INIS)

    Khalil Ullah; Badsha, S.; Khan, A.; Kiani, M.R.; Ahmed, S.A.

    2002-01-01

    Objective: To examine the prevalence, age, sex and topographical distribution of the rheumatic heart diseases and its morphology. Design: A cross sectional descriptive study. Place and Duration of Study: Pathology Department, Army Medical College, Rawalpindi between 1981-1990. Patients and Methods: Five hundred and twenty six surgically excised cardiac valves and biopsies were studied in the laboratory in the light of clinical data. Results: Carditis constituted 87.4 % of the cardiac valvular disease with 23.5% active and 71% healed rheumatic lesions. About 5.5% had morphological appearances consistent with RHD. The lesions affected mitral valves (37.0%), aortic valve (22.1%), mitral and aortic valves together (21.0%) and atrial appendages (19.0%). Presentation was mostly as mitral stenosis either isolated (49.2% ) or combined (31.0%), aortic stenosis (11.7% ) and aortic incompetence with regurgitation (7.3%). Conclusion: Rheumatic carditis constitutes a significant proportion of cardiac valvular disease and affects comparatively younger age, with slight male preponderance and primarily affects mitral valve. (author)

  16. RISK OF INFERTILITY IN PATIENTS WITH CELIAC DISEASE: a meta-analysis of observational studies

    Directory of Open Access Journals (Sweden)

    Juan Sebastian LASA

    2014-04-01

    Full Text Available Context Celiac disease is an autoimmune disorder of the small intestine associated with several extra-intestinal features, such as reproductive disorders. The relationship between celiac disease and infertility has been previously assessed, with conflicting results. Objectives We seek to determine the relationship between celiac disease and infertility. Methods Data was extracted from case-control or cohort design studies from 1966 to December 2013 using the MEDLINE-Pubmed, EMBASE, LILACS and Cochrane Library databases. We analyzed two kinds of trials: those assessing the risk of infertility in subjects with already diagnosed celiac disease, and those evaluating the prevalence of undiagnosed celiac disease in subjects with a diagnosis of infertility. Results The search yielded 413 potentially relevant studies for revision, 12 of which were finally included for analysis. A significant association was found between women with a diagnosis of infertility and undiagnosed celiac disease [OR 3.09 (95% CI 1.74-5.49]. When considering those studies assessing the occurrence of infertility in subjects with already-diagnosed celiac disease, no difference was found between celiac disease patients and control subjects [OR 0.99 (0.86-1.13]. Conclusions Undiagnosed celiac disease is a risk factor for infertility. Women seeking medical advice for this particular condition should be screened for celiac disease. Adoption of a gluten-free diet could have a positive impact on fertility in this group of patients.

  17. Motor association cortex activity in Parkinson's disease. A functional MRI study

    International Nuclear Information System (INIS)

    Tada, Yukiko

    1998-01-01

    The purpose of this study was to examine the activation of motor association cortex using functional magnetic resonance imaging (fMRI) in patients with Parkinson's disease (PD) and control subjects during performed hand movements. There were 26 patients with PD (12 patients with Hoehn and Yahr stage I-II, 14 patients with stage III) and 8 control subjects. Functional imaging was performed using a 1.5 tesla MRI system equipped with a single-shot, echo-planar pulse sequence. The significant signal changes were observed within the primary sensorimotor area, the supplementary motor area (SMA), and the parietal association area in both PD and control subjects. In PD subjects, the SMA was less activated than in control subjects; there were significant differences in the number of pixels activated in SMA between control and Yahr III group (p<0.01), and between Yahr I-II and Yahr III group (p<0.01). Our results demonstrated that movement related cerebral activity in the SMA is reduced in PD subjects, consistent with previously published data using other methods. It is well known from anatomical studies that one of the major cortical outputs of the basal ganglia is the SMA. This may explain the hypoactivation of the SMA in PD. Studies using fMRI provide a promising method not only for localizing cortical activation related to voluntary movements but also for investigating pathophysiology of movement disorders. (author)

  18. Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials

    Science.gov (United States)

    Martinez-Herrera, Mayte; Silvestre-Rangil, Javier

    2017-01-01

    Background Obesity is a very prevalent chronic disease worldwide and has been suggested to increase susceptibility of periodontitis. The aim of this paper was to provide a systematic review of the association between obesity and periodontal disease, and to determine the possible mechanisms underlying in this relationship. Material and Methods A literature search was carried out in the databases PubMed-Medline and Embase. Controlled clinical trials and observational studies identifying periodontal and body composition parameters were selected. Each article was subjected to data extraction and quality assessment. Results A total of 284 articles were identified, of which 64 were preselected and 28 were finally included in the review. All the studies described an association between obesity and periodontal disease, except two articles that reported no such association. Obesity is characterized by a chronic subclinical inflammation that could exacerbate other chronic inflammatory disorders like as periodontitis. Conclusions The association between obesity and periodontitis was consistent with a compelling pattern of increased risk of periodontitis in overweight or obese individuals. Although the underlying pathophysiological mechanism remains unclear, it has been pointed out that the development of insulin resistance as a consequence of a chronic inflammatory state and oxidative stress could be implicated in the association between obesity and periodontitis. Further prospective longitudinal studies are needed to define the magnitude of this association and to elucidate the causal biological mechanisms. Key words:Periodontal disease, periodontitis, periodontal infection, obesity, abdominal obesity. PMID:29053651

  19. Lifestyle Characteristics and Gastroesophageal Reflux Disease: A Population-Based Study in Albania

    Directory of Open Access Journals (Sweden)

    Lulzim Çela

    2013-01-01

    Full Text Available Aim. We aimed to assess the prevalence and lifestyle correlates of gastroesophageal reflux disease (GERD in the adult population of Albania, a Mediterranean country in Southeast Europe which has experienced major behavioral changes in the past two decades. Methods. A cross-sectional study, conducted in 2012, included a population-representative sample of 845 individuals (≥18 years residing in Tirana (345 men, mean age: ; 500 women, mean age: ; response rate: 84.5%. Assessment of GERD was based on Montreal definition. Covariates included socioeconomic characteristics, lifestyle factors, and body mass index. Logistic regression was used to assess the association of socioeconomic characteristics and lifestyle factors with GERD. Results. The overall prevalence of GERD was 11.9%. There were no significant sex differences, but a higher prevalence among the older participants. In fully adjusted models, there was a positive relationship of GERD with smoking, physical inactivity, fried food consumption, and obesity, but not so for alcohol intake and meat consumption. Conclusion. We obtained important evidence on the prevalence and lifestyle correlates of GERD in a Western Balkans' country. Smoking, physical inactivity, and obesity were strong “predictors” of GERD in this population. Findings from this study should be replicated in prospective studies in Albania and other transitional settings.

  20. Does quality of drinking water matter in kidney stone disease: A study in West Bengal, India.

    Science.gov (United States)

    Mitra, Pubali; Pal, Dilip Kumar; Das, Madhusudan

    2018-05-01

    The combined interaction of epidemiology, environmental exposure, dietary habits, and genetic factors causes kidney stone disease (KSD), a common public health problem worldwide. Because a high water intake (>3 L daily) is widely recommended by physicians to prevent KSD, the present study evaluated whether the quantity of water that people consume daily is associated with KSD and whether the quality of drinking water has any effect on disease prevalence. Information regarding residential address, daily volume of water consumption, and source of drinking water was collected from 1,266 patients with kidney stones in West Bengal, India. Drinking water was collected by use of proper methods from case (high stone prevalence) and control (zero stone prevalence) areas thrice yearly. Water samples were analyzed for pH, alkalinity, hardness, total dissolved solutes, electrical conductivity, and salinity. Average values of the studied parameters were compared to determine if there were any statistically significant differences between the case and control areas. We observed that as many as 53.6% of the patients consumed water daily. Analysis of drinking water samples from case and control areas, however, did not show any statistically significant alterations in the studied parameters. All water samples were found to be suitable for consumption. It is not the quality of water, rather the quantity of water consumed that matters most in the occurrence of KSD.

  1. Stressors of School-age Children With Allergic Diseases: A Qualitative Study.

    Science.gov (United States)

    Iio, Misa; Hamaguchi, Mana; Nagata, Mayumi; Yoshida, Koichi

    2018-05-08

    Most studies of stress in children with chronic diseases have been geared toward parents and caregivers have not considered allergic diseases together. This study aimed to identify the stressors associated with allergic diseases in Japanese school-age children. Stressors associated with allergic diseases of 11 school-age children (seven boys and four girls; age range: 9-12 years) were investigated using semi-structured interviews. In the qualitative thematic analysis of stressors about allergic diseases, two themes: allergic disease-specific stressors and common stressors in chronic diseases, and 12 categories were identified. A thematic map was applied to four domains of stressor: physiological factors, psychological factors, social factors, and environmental factors. The results showed that school-age children with allergic diseases have a variety of stressors. Future studies should aim to develop an allergic disease-specific stress management program with school-age children. In children with allergic diseases, not only is stress management in daily life important, but also stress management for disease-specific matters to control the symptoms and maintain mental health. Stress management should be supported for school-age children with allergic diseases. Copyright © 2018 Elsevier Inc. All rights reserved.

  2. The effects of high intensity interval training in women with rheumatic disease: a pilot study.

    Science.gov (United States)

    Sandstad, Janne; Stensvold, Dorthe; Hoff, Mari; Nes, Bjarne M; Arbo, Ingerid; Bye, Anja

    2015-10-01

    Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are inflammatory diseases which involve increased risk of cardiovascular disease (CVD). High intensity interval training (HIIT) is known to be effective in improving cardiovascular health. The aim of this study was to investigate whether 10 weeks of HIIT at 85-95% of HRmax would improve important risk factors of CVD in rheumatic patients, and if these patients would tolerate exercise intensities above today's recommendations. Seven women with RA and eleven with adult-JIA, 20-50 years, were recruited to this cross-over study. Participants performed HIIT, consisting of 4 × 4 min intervals at 85-95% of HRmax twice a week for 10 weeks on spinning bikes. Maximal oxygen uptake (VO2max), heart rate recovery, blood pressure, body composition, and blood variables were measured before and after the exercise and control period. Disease activity was determined and questionnaire data were collected. HIIT resulted in 12.2% increase in VO2max and 2.9% improvement in heart rate recovery (p HIIT (p = 0.08). No changes were detected in disease activity or pain. Despite rigorous high intensity exercise, no increase was detected in disease activity or pain, indicating that HIIT was well tolerated by these patients. Furthermore, HIIT had positive effects on several CVD risk factors. In light of this pilot study, HIIT seems like a promising non-pharmacological treatment strategy for patients with RA and adult-JIA.

  3. Comparative evaluation of two subgingival irrigating solutions in the management of periodontal disease: A clinicomicrobial study

    Directory of Open Access Journals (Sweden)

    Dhara Jayesh Pandya

    2016-01-01

    Full Text Available Context: Local administration of antimicrobial agents offer a “site-specific” approach to the periodontal therapy and it has several benefits. Aim: The present study was aimed to assess the clinical and microbial changes by subgingival irrigation using different subgingival irrigants in periodontitis patients and also to assess the mechanical effect of different local irrigation devices; if any. Settings and Design: Split-mouth design was employed on ten individuals. Materials and Methods: The study sample consisted of 10 individuals in whom full-mouth scaling and root planing was performed and subgingival irrigation therapy was instituted for an experimental period of 30 days. The clinical as well as microbiological parameters were evaluated. Statistical Analysis Used: To calculate baseline data with day thirty data,paired t-test was used. Intergroup comparison was carried out using one-way ANOVA. Multiple comparisons among groups were carried out using post hoc Tamhane's T2 test. Results: Among the different subgingival irrigants used, 0.2% chlorhexidine gluconate is most effective followed by ozonated water, whereas saline was found to be ineffective when compared to the other two subgingival irrigants. Subgingival irrigation using pulsated device may not have any additive effect in alteration of the subgingival microflora. Conclusion: Within the limits and scope of the study, it can be safely concluded that 0.2% chlorhexidine may be used as an adjunct to mechanical therapy for achieving a significant reduction in inflammatory periodontal changes and also reduction in periodontopathogenic microflora.

  4. Preliminary results from a study of the double beta decay of 150Nd

    International Nuclear Information System (INIS)

    Perillo, I.M.C.; Chan, Y.D.; Hurley, D.; Lesko, K.T.; McDonald, R.J.; Moorhead, M.E.; Norman, E.B.; Smith, A.R.; Stokstad, R.G.

    1996-01-01

    We report the preliminary results from a study of the double beta decay of 150 Nd to the first 0 + excited state of 150 Sm. Our data consists of 50 days of counting 5 kg of natural Nd 2 O 3 at the LBNL-Oroville low background facility. The deduced lower limit for the half life of this decay mode is 4.9.10 19 years. (orig.)

  5. Preliminary study: Formaldehyde exposure in laboratories of Sharjah university in UAE

    OpenAIRE

    Ahmed, Hafiz Omer

    2011-01-01

    Objectives : Laboratory technicians, students, and instructors are at high risk, because they deal with chemicals including formaldehyde. Thus, this preliminary study was conducted to measure the concentration of formaldehyde in the laboratories of the University of Sharjah in UAE. Materials and Methods: Thirty-two air samples were collected and analyzed for formaldehyde using National Institute for Occupational Safety and Health (NIOSH) method 3500. In this method, formaldehyde reacts with c...

  6. Reliability of the Filipino version of the Parent Satisfaction Scale: A preliminary study

    OpenAIRE

    Palad, Yves Y.; Madriaga, Gilbert O.

    2014-01-01

    Parent satisfaction is vital in improving the delivery of paediatric health care. However, there are no linguistically appropriate instruments that measure parent satisfaction among Filipino parents of children receiving occupational therapy, physical therapy, and speech pathology services. This study aimed to provide preliminary information about the reliability of the Filipino version of the Parent Satisfaction Scale (F-PSS). Research procedures included forward- and backward-translation of...

  7. Preliminary study of the thermo-hydraulic behaviour of the binary breeder reactor

    International Nuclear Information System (INIS)

    Silveira Luz, M. da; Ferreira, W.J.

    1984-06-01

    Continuing the development of the Binary Breeder Reactor, its physical configuration and the advantages of differents types of spacers are analysed. In order to simulate the thermo-hydraulic behaviour and obtain data for a preliminary evaluation of the core geometry, the COBRA III C code was used to study the effects of the lenght and diameter of the fuel element, the coolant inlet temperature, the system pressure, helicoidal pitch and the pitch to diameter ratio. (Author) [pt

  8. Preliminary Study of 20 MWth Experiment Power Reactor based on Pebble Bed Reactor

    Science.gov (United States)

    Irwanto, Dwi; Permana, Sidik; Pramuditya, Syeilendra

    2017-07-01

    In this study, preliminary design calculations for experimental small power reactor (20 MWt) based on Pebble Bed Reactor (PBR) are performed. PBR technology chosen due to its advantages in neutronic and safety aspects. Several important parameters, such as fissile enrichment, number of fuel passes, burnup and effective multiplication factor are taken into account in the calculation to find neutronic characteristics of the present reactor design.

  9. Uptake of Radium by Grass and Shrubs Grown on Mineral Heaps: A Preliminary Study

    International Nuclear Information System (INIS)

    Laili, Z.; Omar, M.; Yusof, M.A. Wahab; Ibrahim, M.Z.

    2015-01-01

    A preliminary study of the uptake of 226 Ra and 228 Ra by grass and shrubs grown on mineral heaps was carried out. Activity concentrations of 226 Ra and 228 Ra in grass and shrubs were measured using gamma spectrometry. The result showed that grass and shrubs grown on mineral heaps contained elevated levels of radium compared to grass and shrubs grown on normal soils. Thus, these plants might be used for phytoremediation of radium contaminated soil. (author)

  10. Diffusion-weighted MR imaging of cystic lesions of neurocysticercosis: a preliminary study

    International Nuclear Information System (INIS)

    Raffin, Luciana S.; Bacheschi, Luiz A.; Machado, Luis R.; Nobrega, Jose P.S.; Coelho, Christina; Leite, Claudia C.

    2001-01-01

    Neurocysticercosis is an endemic disease in some developing countries. It has pleomorfic clinical and imaging findings, which are variable from patient to patient. In this preliminary note, we studied the magnetic resonance diffusion-weighted images of sixteen patients presenting with cystic lesions of this disease diagnosed by clinical and laboratorial findings. All the lesions had hypointense signal and the similar apparent diffusion coefficient values as the cerebrospinal fluid. (author)

  11. A Preliminary Study of the Use of Conjunctions and the Quality of Writing

    OpenAIRE

    Taeko, Fujisaku

    1999-01-01

    This is a preliminary study that investigates the correlation between the use of conjunctions and the evaluation of writing by examining density and frequency of conjunctions used in student essay writing. Essays written by first-year university students are examined as the end product of high school English teaching in Japan. The results with the current data indicate that the quality of the written texts does not relate to mere density of the use of conjunctions or the use of complex conjun...

  12. Disentangling the effects of insomnia and night work on cardiovascular diseases: a study in nursing professionals

    Energy Technology Data Exchange (ETDEWEB)

    Silva-Costa, A. [Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ (Brazil); Griep, R.H.; Rotenberg, L. [Laboratório de Educação em Ambiente e Saúde, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ (Brazil)

    2014-11-21

    Cardiovascular diseases (CVDs) are known to be associated with poor sleep quality in general populations, but they have not been consistently associated with specific work schedules. Studies of CVD generally do not simultaneously consider sleep and work schedules, but that approach could help to disentangle their effects. We investigated the association between insomnia and a self-reported physician diagnosis of CVD in day and night workers, considering all sleep episodes during nocturnal and diurnal sleep. A cross-sectional study was conducted in 1307 female nursing professionals from 3 public hospitals, using baseline data from the “Health and Work in Nursing - a Cohort Study.” Participants were divided into two groups: i) day workers with no previous experience in night shifts (n=281) and whose data on insomnia were related to nocturnal sleep and ii) those who worked exclusively at night (n=340) and had data on both nocturnal and diurnal sleep episodes, as they often sleep at daytime. Multiple logistic regression analysis was performed. Among day workers, insomnia complaints increased the odds of CVD 2.79-fold (95% CI=1.01-6.71) compared with workers who had no complaints. Among night workers, reports of insomnia during both nocturnal and diurnal sleep increased the odds of reported CVD 3.07-fold (95% CI=1.30-7.24). Workers with insomnia had similar probabilities of reporting CVD regardless of their work schedule, suggesting a relationship to insomnia and not to night work per se. The results also highlighted the importance of including evaluation of all sleep episodes (diurnal plus nocturnal sleep) for night workers.

  13. Tracheostomy in Infants With Congenital Heart Disease: A Nationwide Population-Based Study in Taiwan.

    Science.gov (United States)

    Lee, Yu-Sheng; Jeng, Mei-Jy; Tsao, Pei-Chen; Soong, Wen-Jue; Chou, Pesus

    2016-07-01

    This study aimed to use the National Health Insurance Research Database in Taiwan to examine the risk factors for tracheostomy in infants with congenital heart disease (CHD) and to evaluate the associated mortality risk in those who received a tracheostomy. The study was conducted between 2000 and 2011 with infants assigned to either a CHD group (34,943 subjects) or an age- and sex-matched control group (136,600 subjects). We then performed descriptive, logistic regression, Kaplan-Meier, and Cox regression analyses for the investigation. Infants with CHD had an increased risk of tracheostomy (adjusted hazard ratio [HR], 6.67, 95% CI 4.40-10.10). Congenital airway anomaly (adjusted odds ratio [OR], 15.25, 95% CI 10.56-22.02), neuromuscular impairment (adjusted OR 6.24, 95% CI 4.35-8.94), and time (0-3 y) after CHD diagnosis (adjusted OR 3.27, 95% CI 2.19-4.89) were most highly correlated with tracheostomy placement. The mortality risk was increased in infants with CHD and a tracheostomy even after adjusting for confounders (adjusted HR 3.88, 95% CI 2.96-5.08). Mortality risk (adjusted HR and 95% CI) increased by 2.06 (1.56-2.71), 7.19 (2.42-21.38), and 14.76 (1.46-149.69) after 0-3, 4-7, and 8-11 y of follow-up, respectively. Infants with CHD had an increased risk of undergoing tracheostomy. The mortality risk is significantly increased in infants with CHD and tracheostomy, and the risk increases progressively with time. Further studies are warranted to clarify the mechanisms underlying the risks associated with tracheostomy. Copyright © 2016 by Daedalus Enterprises.

  14. Disentangling the effects of insomnia and night work on cardiovascular diseases: a study in nursing professionals

    International Nuclear Information System (INIS)

    Silva-Costa, A.; Griep, R.H.; Rotenberg, L.

    2014-01-01

    Cardiovascular diseases (CVDs) are known to be associated with poor sleep quality in general populations, but they have not been consistently associated with specific work schedules. Studies of CVD generally do not simultaneously consider sleep and work schedules, but that approach could help to disentangle their effects. We investigated the association between insomnia and a self-reported physician diagnosis of CVD in day and night workers, considering all sleep episodes during nocturnal and diurnal sleep. A cross-sectional study was conducted in 1307 female nursing professionals from 3 public hospitals, using baseline data from the “Health and Work in Nursing - a Cohort Study.” Participants were divided into two groups: i) day workers with no previous experience in night shifts (n=281) and whose data on insomnia were related to nocturnal sleep and ii) those who worked exclusively at night (n=340) and had data on both nocturnal and diurnal sleep episodes, as they often sleep at daytime. Multiple logistic regression analysis was performed. Among day workers, insomnia complaints increased the odds of CVD 2.79-fold (95% CI=1.01-6.71) compared with workers who had no complaints. Among night workers, reports of insomnia during both nocturnal and diurnal sleep increased the odds of reported CVD 3.07-fold (95% CI=1.30-7.24). Workers with insomnia had similar probabilities of reporting CVD regardless of their work schedule, suggesting a relationship to insomnia and not to night work per se. The results also highlighted the importance of including evaluation of all sleep episodes (diurnal plus nocturnal sleep) for night workers

  15. Prevalence and clinical correlation of dysphagia in Parkinson disease: a study on Chinese patients.

    Science.gov (United States)

    Ding, X; Gao, J; Xie, C; Xiong, B; Wu, S; Cen, Z; Lou, Y; Lou, D; Xie, F; Luo, W

    2018-01-01

    Dysphagia is relatively common in patients with Parkinson disease (PD) and can have a negative impact on their quality of life; therefore, it is imperative that its prevalence in PD patients is studied. The aim of this study was to explore the prevalence and clinical correlation of dysphagia in Chinese PD patients. We recruited 116 Chinese PD patients. A videofluoroscopic study of swallowing (VFSS) was used to identify dysphagia. Assessments, including water drinking test, relative motor symptoms, non-motor symptoms (NMS) and quality of life, were performed to analyze the risks of dysphagia. The prevalence of dysphagia was 87.1%. The comparison of demographic and clinical features between patients with and without dysphagia included sex, education level, disease course, Mini-mental State Examination (MMSE), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Question 6, 7 of the Unified Parkinson Disease Rating Scale (UPDRS Part II), Hoehn-Yahr stage (H&Y), water drinking test, 39-item Parkinson Disease Questionnaire (PDQ-39) and Non-Motor Symptoms Quest (NMSQ). We found significant correlations between dysphagia and age. Using age, disease course, and H&Y stage as the independent variable in our regression analysis for assessing the risk factors of dysphagia in PD patients, age and H&Y stage displayed a strong correlation as the risk factors. The risk of dysphagia in elderly PD patients is 1.078 times greater than that of younger PD patients. Also, the risk of dysphagia in PD patients of a greater H&Y staging is 3.260 times greater than that of lower staging PD patients. Our results suggest that dysphagia is common in Chinese PD patients. Older patients or those in higher H&Y stages are more likely to experience dysphagia. There is no correlation between dysphagia and PD duration.

  16. Hormone replacement therapy is associated with gastro-oesophageal reflux disease: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Close Helen

    2012-05-01

    Full Text Available Abstract Background Oestrogen and progestogen have the potential to influence gastro-intestinal motility; both are key components of hormone replacement therapy (HRT. Results of observational studies in women taking HRT rely on self-reporting of gastro-oesophageal symptoms and the aetiology of gastro-oesophageal reflux disease (GORD remains unclear. This study investigated the association between HRT and GORD in menopausal women using validated general practice records. Methods 51,182 menopausal women were identified using the UK General Practice Research Database between 1995–2004. Of these, 8,831 were matched with and without hormone use. Odds ratios (ORs were calculated for GORD and proton-pump inhibitor (PPI use in hormone and non-hormone users, adjusting for age, co-morbidities, and co-pharmacy. Results In unadjusted analysis, all forms of hormone use (oestrogen-only, tibolone, combined HRT and progestogen were statistically significantly associated with GORD. In adjusted models, this association remained statistically significant for oestrogen-only treatment (OR 1.49; 1.18–1.89. Unadjusted analysis showed a statistically significant association between PPI use and oestrogen-only and combined HRT treatment. When adjusted for covariates, oestrogen-only treatment was significant (OR 1.34; 95% CI 1.03–1.74. Findings from the adjusted model demonstrated the greater use of PPI by progestogen users (OR 1.50; 1.01–2.22. Conclusions This first large cohort study of the association between GORD and HRT found a statistically significant association between oestrogen-only hormone and GORD and PPI use. This should be further investigated using prospective follow-up to validate the strength of association and describe its clinical significance.

  17. Personality traits and the risk for Parkinson disease: a prospective study.

    Science.gov (United States)

    Sieurin, Johanna; Gustavsson, Petter; Weibull, Caroline Elise; Feldman, Adina Leiah; Petzinger, Giselle Maria; Gatz, Margaret; Pedersen, Nancy Lee; Wirdefeldt, Karin

    2016-02-01

    In this study, we explored the association between the personality traits, neuroticism and introversion, and risk of Parkinson disease (PD). A population-based cohort study was conducted using questionnaire data from the Swedish Twin Registry for twins born 1926-1958 (n > 29,000). Personality traits were assessed in 1973 by a short form of Eysenck's Personality Inventory. The cohort was followed from 1974 to 2012 through Swedish patient and cause of death registers for PD ascertainment. Cox proportional hazards regression was used to estimate subsequent risk of PD, adjusting for attained age, sex and smoking. A mediation analysis was performed to further explore the role of smoking in the relationship between personality trait and PD. Confounding by familial factors was explored using a within-pair analysis. During a mean follow-up time of 36.8 years, 197 incident PD cases were identified. Both neuroticism and introversion were associated with an increased risk of PD after adjustment. Smoking was a significant mediator in the relationship between personality traits and PD that partly accounted for the effect of introversion, whereas it acted as a suppressor for the effect of neuroticism on PD risk. In the within-pair analyses, associations for neuroticism and introversion were attenuated. In conclusion, our study provides evidence that neuroticism is associated with an increased risk of PD that is in part suppressed by smoking. There was a weak association between introversion and PD and this effect was at least partly mediated through smoking. The observed effects may partly be explained by familial factors shared by twins.

  18. Disentangling the effects of insomnia and night work on cardiovascular diseases: a study in nursing professionals

    Directory of Open Access Journals (Sweden)

    A. Silva-Costa

    2015-02-01

    Full Text Available Cardiovascular diseases (CVDs are known to be associated with poor sleep quality in general populations, but they have not been consistently associated with specific work schedules. Studies of CVD generally do not simultaneously consider sleep and work schedules, but that approach could help to disentangle their effects. We investigated the association between insomnia and a self-reported physician diagnosis of CVD in day and night workers, considering all sleep episodes during nocturnal and diurnal sleep. A cross-sectional study was conducted in 1307 female nursing professionals from 3 public hospitals, using baseline data from the “Health and Work in Nursing - a Cohort Study.” Participants were divided into two groups: i day workers with no previous experience in night shifts (n=281 and whose data on insomnia were related to nocturnal sleep and ii those who worked exclusively at night (n=340 and had data on both nocturnal and diurnal sleep episodes, as they often sleep at daytime. Multiple logistic regression analysis was performed. Among day workers, insomnia complaints increased the odds of CVD 2.79-fold (95% CI=1.01-6.71 compared with workers who had no complaints. Among night workers, reports of insomnia during both nocturnal and diurnal sleep increased the odds of reported CVD 3.07-fold (95% CI=1.30-7.24. Workers with insomnia had similar probabilities of reporting CVD regardless of their work schedule, suggesting a relationship to insomnia and not to night work per se. The results also highlighted the importance of including evaluation of all sleep episodes (diurnal plus nocturnal sleep for night workers.

  19. Association Between Epicardial Fat Thickness and Premature Coronary Artery Disease: A Case Control Study

    Science.gov (United States)

    Faghihi, Shadi; Vasheghani-Farahani, Ali; Parsaee, Mozhgan; Saedi, Sedigheh; Ghadrdoost, Behshid

    2015-01-01

    Background: The association between epicardial fat thickness (EFT) and premature coronary artery disease (CAD) has not been elaborately studied. Objectives: In the present study, we sought whether such a relationship between EFT and CAD exists. Patients and Methods: Sixty two consecutive subjects, under 50 years of age, who underwent coronary angiography (CAG) with the aspect of CAD, were included in this case control study. They were divided into two groups of 31 subjects, namely CAD (cases) and non-CAD (controls) group, according to CAG data. Presence of conventional coronary risk factors, drug history, and anthropometric data were recorded. Then, each subject underwent standard transthoracic echocardiography for measuring EFT in the proximal part of right ventricular outflow tract in the parasternal long axis view at end diastole, as well as other parameters of systolic and diastolic function, and left ventricle (LV) mass. Images were stored for offline analysis when the echocardiocardiographers were blind to CAG data. Results: Among baseline characteristics, waist circumference, triglyceride levels, cigarette smoking and history of statin use were significantly higher in the CAD group. The body mass index (BMI) was significantly higher in the non-CAD group. According to echocardiographic data, the EFT with a cut off value of 2.95 mm could well differentiate subjects in each group. The LV mass and E/e were significantly higher in CAD group, in addition to EFT. Also, there was a significant correlation between EFT and waist circumference, as well as LV mass. However, no significant relation was between EFT and LV systolic and diastolic function. Conclusions: The EFT, as measured by echocardiography, with a cut off value 2.95 mm has a strong association with premature CAD. PMID:26380819

  20. A Novel Combination Therapy for Patients With Dry Eye Disease: A Pilot Study.

    Science.gov (United States)

    Smith, Will; McMahon, David; Nymark, Maria

    2018-05-01

    Context • Approximately 25% of the US population suffers from dry eyes or some abnormality of the exposed ocular surface. Investigation of effective modalities for their management is needed. Objective • The study intended to examine the efficacy of a proprietary, daily, Dry Eye Protocol consisting of daily use of a moist, heated, ocular compress and intake of an omega-3 dietary supplement in treatment of ocular surface disease. Design • The research team designed a 4-wk, clinically based, open-label, multicenter cohort study. Setting • The study took place at 6 private eye care practices throughout the United States: Beverly Hills, CA, USA; San Diego, CA, USA; Sunnyvale, CA, USA; Park City, UT, USA; Tarpon Spring, FL, USA; and Kennewick, WA, USA. Participants • Participants were adults between 18 and 75 y of age who had established ocular surface disease based on clinical findings and the results of testing using the ocular surface disease index (OSDI). Intervention • For period of 30 d, participants used a combined daily protocol that included (1) application of a moist, heated, eye compress and (2) a nutritional therapy via an omega-3 supplement in an oral triglyceride form. Outcome Measures • Measures included the OSDI and a test of tear break-up time (TBUT). Results • Of the original 35 participants, 33 completed the 4-wk protocol. The participants using the proprietary Dry Eye Protocol showed significant improvements from baseline, demonstrated by a 49% decrease in OSDI scores (P = .0015); and 46% of participants reported becoming asymptomatic of dry eye symptoms. A significant improvement was also observed in TBUT, increasing from 3.0 to 5.4 s. Conclusions • Daily use of the proprietary Dry Eye Protocol that included a high dosage of triglyceride omega-3 and use of a moist, heated, compress daily showed significant improvement for participants in OSDI and TBUT and should be considered to be a first-line therapy for patients with dry eye

  1. Relationships between sexual violence and chronic disease: a cross-sectional study.

    Science.gov (United States)

    Santaularia, Jeanie; Johnson, Monica; Hart, Laurie; Haskett, Lori; Welsh, Ericka; Faseru, Babalola

    2014-12-16

    Sexual assault is a traumatic event with potentially devastating lifelong effects on physical and mental health. Research has demonstrated that individuals who experience sexual assault during childhood are more likely to engage in risky behaviors later in life, such as smoking, alcohol and drug use, and disordered eating habits, which may increase the risk of developing a chronic disease. Despite the high prevalence and economic burden of sexual assault, few studies have investigated the associations between sexual violence and chronic health conditions in the US. The purpose of this study is to identify associations between sexual violence and health risk behaviors, chronic health conditions and mental health conditions utilizing population based data in Kansas. Secondary analysis was done using data from the 2011 Kansas Behavioral Risk Factor Surveillance System sexual violence module (N = 4,886). Crude and adjusted prevalence rate ratios were computed to examine associations between sexual assault and health risk behaviors, chronic health conditions and mental health conditions, overall and after adjusting for social demographic characteristics. Additional logistic regression models were implemented to examine the association between sexual assault and health risk behaviors with further adjustment for history of anxiety or depression. There was a significantly higher prevalence of health risk behaviors (heavy drinking, binge drinking and current smoking), chronic health conditions (disability, and current asthma) and mental health conditions (depression, anxiety, and suicidal ideation) among women who ever experienced sexual assault compared to women who did not, even after adjustment for potential confounders. Study findings highlight the need for chronic disease prevention services for victims of sexual violence. There are important implications for policies and practices related to primary, secondary, and tertiary prevention, as well as collaborations

  2. Progression of motor subtypes in Huntington's disease: a 6-year follow-up study.

    Science.gov (United States)

    Jacobs, M; Hart, E P; van Zwet, E W; Bentivoglio, A R; Burgunder, J M; Craufurd, D; Reilmann, R; Saft, C; Roos, R A C

    2016-10-01

    The objective of this study is to investigate the progression of predominantly choreatic and hypokinetic-rigid signs in Huntington's disease (HD) and their relationship with cognitive and general functioning over time. The motor signs in HD can be divided into predominantly choreatic and hypokinetic-rigid subtypes. It has been reported in cross-sectional studies that predominantly choreatic HD patients perform better on functional and cognitive assessments compared to predominantly hypokinetic-rigid HD patients. The course of these motor subtypes and their clinical profiles has not been investigated longitudinally. A total of 4135 subjects who participated in the European HD Network REGISTRY study were included and classified at baseline as either predominantly choreatic (n = 891), hypokinetic-rigid (n = 916), or mixed-motor (n = 2328), based on a previously used method. The maximum follow-up period was 6 years. The mixed-motor group was not included in the analyses. Linear mixed models were constructed to investigate changes in motor subtypes over time and their relationship with cognitive and functional decline. Over the 6-year follow-up period, the predominantly choreatic group showed a significant decrease in chorea, while hypokinetic-rigid symptoms slightly increased in the hypokinetic-rigid group. On the Total Functional Capacity, Stroop test, and Verbal fluency task the rate of change over time was significantly faster in the predominantly choreatic group, while on all other clinical assessments the decline was comparable for both groups. Our results suggest that choreatic symptoms decrease over time, whereas hypokinetic-rigid symptoms slightly increase in a large cohort of HD patients. Moreover, different motor subtypes can be related to different clinical profiles.

  3. The efficacy of diagnostic battery in Pott′s disease: A prospective study

    Directory of Open Access Journals (Sweden)

    Manoj Kumar

    2014-01-01

    Full Text Available Background: The diagnosis of Pott′s disease is mostly based on clinicoradiological observations substantiated by the bacterial culture, staining and histopathology. Since, no single technique is enough to conclude Pott′s disease in diagnosis, the present study was undertaken to correlate the clinicoradiological, microbiological, histopathological and molecular method to evaluate the effectiveness in diagnosis of Pott′s disease. Materials and Methods: 62 clinicoradiologically suspected cases of Pott′s disease were included in this study. The specimens for diagnostic work up were collected either during surgery or by computed tomography guided fine needle aspiration. All these specimens were tested for tuberculosis (TB through Ziehl-Neelsen (ZN microscopy, BACTEC culture, histopathology and polymerase chain reaction (PCR. The final diagnosis was established by the results of performed tests and clinicoradiological improvement of cases at the end of 6 months on anti tubercular treatment. Results: Out of 62 cases, 7 were excluded from this study as these were turned out to be neoplastic lesions on histopathology. Amongst remaining 55 cases, the TB was diagnosed in 39 (71% on histopathology, 37 (67.5% on PCR, 27 (49% on BACTEC culture and 20 (36.3% on ZN microscopy. Ultimately 45 cases were tested as positive and 10 were detected as negative for TB in combination of ZN microscopy, BACTEC culture and histopathology. PCR was positive in 37 of 45 cases and 10/55 cases remained negative. On clinical analysis of these 10 cases, it was noted that these were cases of relapse/poor compliance. The combination of PCR and histopathology was also shown positive for TB in 45 cases. Hence, the PCR showed a fair positive agreement (Κc = 0.63 against the combined results of all performed traditional methods. Conclusions: The combination of PCR and histopathology is a rapid and efficient tool for diagnosis of Pott′s disease.

  4. Declining financial capacity in patients with mild Alzheimer disease: a one-year longitudinal study.

    Science.gov (United States)

    Martin, Roy; Griffith, H Randall; Belue, Katherine; Harrell, Lindy; Zamrini, Edward; Anderson, Britt; Bartolucci, Alfred; Marson, Daniel

    2008-03-01

    The objective of this study was to investigate change over time in financial abilities in patients with mild Alzheimer disease (AD). The authors conducted a prospective 1-year longitudinal study at a large southern U.S. metropolitan-area medical school university. Participants included healthy older adults (N=63) and patients with mild AD (N=55). The authors conducted a standardized performance measure of financial capacity. Performance was assessed on 18 financial tasks, nine domains of financial activity, and overall financial capacity. Capacity outcomes classifications (capable, marginally capable, or incapable) for domains and overall performance were made using cut scores referenced to comparison group performance. At baseline, patients with mild AD performed significantly below healthy older adults on 16 of 18 tasks, on all nine domains, and on overall financial capacity. At one-year follow up, comparison group performance was stable on all variables. In contrast, patients with mild AD showed substantial declines in overall financial capacity, on eight of nine domains, and on 12 of 18 tasks. Similarly, the proportion of the mild AD group classified as marginally capable and incapable increased substantially over one year for the two overall scores and for five financial domains. Financial capacity is already substantially impaired in patients with mild AD at baseline and undergoes rapid additional decline over one year. Relative to the comparison group, overall financial capacity performance in the AD group declined 10%, from approximately 80% of the comparison group performance at baseline to 70% at follow up. Financial skills showed differential rates of decline on both simple and complex tasks. Of clinical and public policy interest was the declining judgment of patients with mild AD regarding simple fraud schemes. The study supports the importance of prompt financial supervision and planning for patients newly diagnosed with AD.

  5. Whole-Exome Sequencing in Adults With Chronic Kidney Disease: A Pilot Study.

    Science.gov (United States)

    Lata, Sneh; Marasa, Maddalena; Li, Yifu; Fasel, David A; Groopman, Emily; Jobanputra, Vaidehi; Rasouly, Hila; Mitrotti, Adele; Westland, Rik; Verbitsky, Miguel; Nestor, Jordan; Slater, Lindsey M; D'Agati, Vivette; Zaniew, Marcin; Materna-Kiryluk, Anna; Lugani, Francesca; Caridi, Gianluca; Rampoldi, Luca; Mattoo, Aditya; Newton, Chad A; Rao, Maya K; Radhakrishnan, Jai; Ahn, Wooin; Canetta, Pietro A; Bomback, Andrew S; Appel, Gerald B; Antignac, Corinne; Markowitz, Glen S; Garcia, Christine K; Kiryluk, Krzysztof; Sanna-Cherchi, Simone; Gharavi, Ali G

    2018-01-16

    The utility of whole-exome sequencing (WES) for the diagnosis and management of adult-onset constitutional disorders has not been adequately studied. Genetic diagnostics may be advantageous in adults with chronic kidney disease (CKD), in whom the cause of kidney failure often remains unknown. To study the diagnostic utility of WES in a selected referral population of adults with CKD. Observational cohort. A major academic medical center. 92 adults with CKD of unknown cause or familial nephropathy or hypertension. The diagnostic yield of WES and its potential effect on clinical management. Whole-exome sequencing provided a diagnosis in 22 of 92 patients (24%), including 9 probands with CKD of unknown cause and encompassing 13 distinct genetic disorders. Among these, loss-of-function mutations were identified in PARN in 2 probands with tubulointerstitial fibrosis. PARN mutations have been implicated in a short telomere syndrome characterized by lung, bone marrow, and liver fibrosis; these findings extend the phenotype of PARN mutations to renal fibrosis. In addition, review of the American College of Medical Genetics actionable genes identified a pathogenic BRCA2 mutation in a proband who was diagnosed with breast cancer on follow-up. The results affected clinical management in most identified cases, including initiation of targeted surveillance, familial screening to guide donor selection for transplantation, and changes in therapy. The small sample size and recruitment at a tertiary care academic center limit generalizability of findings among the broader CKD population. Whole-exome sequencing identified diagnostic mutations in a substantial number of adults with CKD of many causes. Further study of the utility of WES in the evaluation and care of patients with CKD in additional settings is warranted. New York State Empire Clinical Research Investigator Program, Renal Research Institute, and National Human Genome Research Institute of the National Institutes of

  6. The CREST-E study of creatine for Huntington disease: A randomized controlled trial.

    Science.gov (United States)

    Hersch, Steven M; Schifitto, Giovanni; Oakes, David; Bredlau, Amy-Lee; Meyers, Catherine M; Nahin, Richard; Rosas, Herminia Diana

    2017-08-08

    To investigate whether creatine administration could slow progressive functional decline in adults with early symptoms of Huntington disease. We conducted a multicenter, randomized, double-blind, placebo-controlled study of up to 40 g daily of creatine monohydrate in participants with stage I and II HD treated for up to 48 months. The primary outcome measure was the rate of change in total functional capacity (TFC) between baseline and end of follow-up. Secondary outcome measures included changes in additional clinical scores, tolerability, and quality of life. Safety was assessed by adverse events and laboratory studies. At 46 sites in North America, Australia, and New Zealand, 553 participants were randomized to creatine (275) or placebo (278). The trial was designed to enroll 650 patients, but was halted for futility after the first interim analysis. The estimated rates of decline in the primary outcome measure (TFC) were 0.82 points per year for participants on creatine, 0.70 points per year for participants on placebo, favoring placebo (nominal 95% confidence limits -0.11 to 0.35). Adverse events, mainly gastrointestinal, were significantly more common in participants on creatine. Serious adverse events, including deaths, were more frequent in the placebo group. Subgroup analysis suggested that men and women may respond differently to creatine treatment. Our data do not support the use of creatine treatment for delaying functional decline in early manifest HD. NCT00712426. This study provides Class II evidence that for patients with early symptomatic HD, creatine monohydrate is not beneficial for slowing functional decline. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  7. [Mindfulness-based stimulation in advanced Alzheimer's disease: A comparative, non-inferiority, clinical pilot study].

    Science.gov (United States)

    Quintana Hernández, Domingo Jesús; Miró Barrachina, María Teresa; Ibáñez Fernández, Ignacio; Santana del Pino, Angelo; Rojas Hernández, Jaime; Rodríguez García, Javier; Quintana Montesdeoca, María del Pino

    2015-01-01

    A longitudinal study was conducted in order to analyze the feasibility, safety, and effects of the practice of mindfulness, relaxation and cognitive stimulation on the evolution of Alzheimer's disease, with the aim of testing the equivalence of these interventions. There were a total of 168 participants with probable Alzheimer's disease (AD) treated with donepezil. In the present article, the 21 participants with advanced AD who completed a follow-up period of 24 months are presented. The participants were grouped into three experimental groups (mindfulness, relaxation, and cognitive stimulation) and one control group. Each group carried out three weekly sessions with bi-annual follow-up measurements (cognition: CAMCOG and MMSE; functionality: RDRS; psychopathology: NPI). Non-parametric analyses were performed. The cognitive function and functionality scores showed no significant differences between the groups. However, the scores in cognitive function of the mindfulness group and the cognitive stimulation group did not decrease in an intra-group analysis. In NPI, there were significant differences between the mindfulness group and the control group by the end of the study (P<.017). The data showed that the treatment with donepezil in combination with mindfulness or cognitive stimulation presented a better clinical evolution than the pharmacological treatment alone or combined with relaxation. These data suggest that these therapeutic alternatives should be investigated further, and that the non-pharmacological treatments should be recommended in clinical practice in order to control the evolution of AD in the long term. In order to confirm these findings, a larger study is necessary. Copyright © 2014 SEGG. Published by Elsevier Espana. All rights reserved.

  8. Impact of gender and genetics on emotion processing in Parkinson's disease - A multimodal study

    Directory of Open Access Journals (Sweden)

    Julia Heller

    Full Text Available Background: Parkinson's disease (PD has been suggested to affect males and females differently. Neuropsychiatric symptoms are common and disabling in PD. However, previous studies focusing on emotion recognition in PD have neglected the confounder of gender and lack evidence on the underlying endocrinal and genetic mechanisms. Moreover, while there are many imaging studies on emotion processing in PD, gender-related analyses of neural data are scarce. We therefore aimed at exploring the interplay of the named factors on emotion recognition and processing in PD. Methods: 51 non-demented PD patients (26 male and 44 age- and gender-matched healthy controls (HC; 25 male were examined clinically and neuropsychologically including an emotion recognition task (Ekman 60faces test. A subsample of 25 patients and 31 HC underwent task-based functional magnetic resonance imaging (fMRI comprised of videos of emotional facial expressions. To examine the impact of hormones and genetics on emotion processing, blood samples were taken for endocrinal (testosterone, estradiol, progesterone and genetic testing (5-HTTLPR, Val158Met COMT polymorphisms. Results: No group or gender differences emerged regarding cognitive abilities. Male but not female PD patients exhibited confined impairments in recognizing the emotion anger accompanied by diminished neural response to facial expressions (e.g. in the putamen and insula. Endocrinologically, fear recognition was positively correlated with estrogen levels in female patients, while on the genetic level we found an effect of Val158Met COMT genotype on the recognition of fear in PD patients. Conclusions: Our study provides evidence that impaired emotion processing in PD specifically affects male patients, and that hormones and genetics contribute to emotion recognition performance. Further research on the underlying neural, endocrinological and genetic mechanisms of specific symptoms in PD is of clinical relevance, as it

  9. Illness perceptions in adult congenital heart disease: A multi-center international study.

    Science.gov (United States)

    Rassart, Jessica; Apers, Silke; Kovacs, Adrienne H; Moons, Philip; Thomet, Corina; Budts, Werner; Enomoto, Junko; Sluman, Maayke A; Wang, Jou-Kou; Jackson, Jamie L; Khairy, Paul; Cook, Stephen C; Subramanyan, Raghavan; Alday, Luis; Eriksen, Katrine; Dellborg, Mikael; Berghammer, Malin; Johansson, Bengt; Rempel, Gwen R; Menahem, Samuel; Caruana, Maryanne; Veldtman, Gruschen; Soufi, Alexandra; Fernandes, Susan M; White, Kamila S; Callus, Edward; Kutty, Shelby; Luyckx, Koen

    2017-10-01

    Illness perceptions are cognitive frameworks that patients construct to make sense of their illness. Although the importance of these perceptions has been demonstrated in other chronic illness populations, few studies have focused on the illness perceptions of adults with congenital heart disease (CHD). This study examined (1) inter-country variation in illness perceptions, (2) associations between patient characteristics and illness perceptions, and (3) associations between illness perceptions and patient-reported outcomes. Our sample, taken from APPROACH-IS, consisted of 3258 adults with CHD from 15 different countries. Patients completed questionnaires on illness perceptions and patient-reported outcomes (i.e., quality of life, perceived health status, and symptoms of depression and anxiety). Patient characteristics included sex, age, marital status, educational level, employment status, CHD complexity, functional class, and ethnicity. Linear mixed models were applied. The inter-country variation in illness perceptions was generally small, yet patients from different countries differed in the extent to which they perceived their illness as chronic and worried about their illness. Patient characteristics that were linked to illness perceptions were sex, age, employment status, CHD complexity, functional class, and ethnicity. Higher scores on consequences, identity, and emotional representation, as well as lower scores on illness coherence and personal and treatment control, were associated with poorer patient-reported outcomes. This study emphasizes that, in order to gain a deeper understanding of patients' functioning, health-care providers should focus not only on objective indicators of illness severity such as the complexity of the heart defect, but also on subjective illness experiences. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Biochemical and clinical effects of Whey protein supplementation in Parkinson's disease: A pilot study.

    Science.gov (United States)

    Tosukhowong, Piyaratana; Boonla, Chanchai; Dissayabutra, Thasinas; Kaewwilai, Lalita; Muensri, Sasipa; Chotipanich, Chanisa; Joutsa, Juho; Rinne, Juha; Bhidayasiri, Roongroj

    2016-08-15

    Parkinson's disease (PD) is an oxidative stress-mediated degenerative disorder. Elevated plasma homocysteine (Hcy) is frequently found in the levodopa-treated PD patients, is associated with disease progression and is a marker of oxidative stress. Whey protein is a rich source of cysteine, and branched-chain amino acids (BCAA). It has been shown that supplementation with Whey protein increases glutathione synthesis and muscle strength. In this study, we conducted a placebo-controlled, double-blind study (NCT01662414) to investigate the effects of undenatured Whey protein isolate supplementation for 6months on plasma glutathione, plasma amino acids, and plasma Hcy in PD patients. Clinical outcome assessments included the unified Parkinson's disease rating scale (UPDRS) and striatal L-3,4-dihydroxy-6-(18)F-fluorophenylalanine (FDOPA) uptake were determined before and after supplementation. 15 patients received Whey protein, and 17 received Soy protein, served as a control group. Significant increases in plasma concentration of reduced glutathione and the ratio of reduced to oxidized glutathione were found in the Whey-supplemented patients but not in a control group. This was associated with a significant decrease of plasma levels of Hcy. The plasma levels of total glutathione were not significantly changed in either group. Plasma BCAA and essential amino acids (EAA) were significantly increased in the Whey-supplemented group only. The UPDRS and striatal FDOPA uptake in PD patients were not significantly ameliorated in either group. However, significant negative correlation was observed between the UPDRS and plasma BCAA and EAA in the pre-supplemented PD patients. This study is the first to report that Whey protein supplementation significantly increases plasma reduced glutathione, the reduced to oxidized glutathione ratio, BCAAs and EAAs in patients with PD, together with a concomitant significant reduction of plasma Hcy. However, there were no significant changes in

  11. Comprehension of metaphors and idioms in patients with Alzheimer's disease: a longitudinal study.

    Science.gov (United States)

    Papagno, C

    2001-07-01

    Language in patients with Alzheimer's disease has been extensively studied, with the exception of non-literal language comprehension. However, in our speech, we often make use of expressions, which are not necessarily interpreted on a literal ground. Comprehension of metaphors and idioms was examined in 39 patients with probable early Alzheimer's disease. The results showed that the decline of figurative language is not an early symptom of dementia and can occur independently from the impairment of propositional language. It was also found that metaphors and idioms differ as far as the predominant kind of error is concerned.

  12. Job strain and ischemic heart disease: a prospective study using a new approach for exposure assessment

    DEFF Research Database (Denmark)

    Bonde, Jens Peter; Munch-Hansen, Torsten; Agerbo, Esben

    2009-01-01

    BACKGROUND: Prolonged psychosocial load at the workplace may increase the risk of ischemic heart disease (IHD), but the issue is still unsettled. We analyzed the association between psychosocial workload and risk of IHD using a new approach allocating measures of psychosocial load to individuals...... based on the average exposure level in minor work units. METHODS: Cohort study of 18,258 Danish public service workers in 1106 work units; 79% were women; 108 subjects with history of cardiovascular disease were excluded from the follow-up. The outcome was hospitalization due to IHD (angina pectoris...

  13. Eurythmy therapy in chronic disease: a four-year prospective cohort study

    Directory of Open Access Journals (Sweden)

    Willich Stefan N

    2007-04-01

    Full Text Available Abstract Background Many patients with chronic diseases use complementary therapies, often provided by their physicians. In Germany, several physician-provided complementary therapies have been reimbursed by health insurance companies as part of health benefit programs. In most of these therapies, the patient has a predominantly passive role. In eurythmy therapy, however, patients actively exercise specific movements with the hands, the feet or the whole body. The purpose of this study was to describe clinical outcomes in patients practising eurythmy therapy exercises for chronic diseases. Methods In conjunction with a health benefit program, 419 outpatients from 94 medical practices in Germany, referred to 118 eurythmy therapists, participated in a prospective cohort study. Main outcomes were disease severity (Disease and Symptom Scores, physicians' and patients' assessment on numerical rating scales 0–10 and quality of life (adults: SF-36, children aged 8–16: KINDL, children 1–7: KITA. Disease Score was documented after 0, 6 and 12 months, other outcomes after 0, 3, 6, 12, 18, 24, and (SF-36 and Symptom Score 48 months. Results Most common indications were mental disorders (31.7% of patients; primarily depression, fatigue, and childhood emotional disorder and musculoskeletal diseases (23.4%. Median disease duration at baseline was 3.0 years (interquartile range 1.0–8.5. Median number of eurythmy therapy sessions was 12 (interquartile range 10–19, median therapy duration was 119 days (84–188. All outcomes improved significantly between baseline and all subsequent follow-ups (exceptions: KITA Psychosoma in first three months and KINDL. Improvements from baseline to 12 months were: Disease Score from mean (standard deviation 6.65 (1.81 to 3.19 (2.27 (p Adverse reactions to eurythmy therapy occurred in 3.1% (13/419 of patients. No patient stopped eurythmy therapy due to adverse reactions. Conclusion Patients practising eurythmy therapy

  14. How do patients at risk portray candidates for coronary heart disease? A qualitative interview study

    DEFF Research Database (Denmark)

    Frich, J.C.; Malterud, K.; Fugelli, P.

    2007-01-01

    OBJECTIVE: To explore how patients at risk of coronary heart disease (CHD) portray candidates for CHD. DESIGN: Qualitative interview study. SETTING: Norway. SUBJECTS: A total of 20 men and 20 women diagnosed with heterozygous familial hypercholesterolemia (FH) recruited through a lipid clinic. MAIN...... considered their notions to be valid for assessing people's risk of CHD, others questioned how valid their notions were. CONCLUSION: Doctors should recognize that distancing is a way patients cope with risk and that such a strategy may have psychological and moral reasons. When communicating about risk...

  15. Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts.

    Science.gov (United States)

    Sarno, Euzenir Nunes; Duppre, Nadia Cristina; Sales, Anna Maria; Hacker, Mariana Andréa; Nery, José Augusto; de Matos, Haroldo José

    2012-12-01

    Contact surveillance is a valuable strategy for controlling leprosy. A dynamic cohort study of leprosy contacts was initiated in 1987 at Oswaldo Cruz Foundation. The objective of this work was to review the data on the major risk factors leading up to the infectious stage of the disease, estimate incidence rates of leprosy in the cohort and characterise the risk factors for the disease among the contacts under surveillance. The incidence rate of leprosy among contacts of leprosy patients was estimated at 0.01694 cases per person-year in the first five years of follow-up. The following factors were associated with acquiring the disease: (i) not receiving the BCG vaccine, (ii) a negative Mitsuda reaction and (iii) contact with a patient with a multibacillary clinical form of leprosy. The contacts of index patients who had high bacilloscopic index scores > 1 were at especially high risk of infection. The following factors were associated with infection, which was defined as a seropositive reaction for anti-phenolic glicolipid-1 IgM: (i) young age (< 20 years), (ii) a low measured Mitsuda reaction (< 5 mm) and (iii) contact with an index patient who had a high bacilloscopic index. BCG vaccination and re-vaccination were shown to be protective among household contacts. The main conclusions of this study indicate an urgent need for additional leprosy control strategies in areas with a high incidence of the disease.

  16. Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts

    Directory of Open Access Journals (Sweden)

    Euzenir Nunes Sarno

    2012-12-01

    Full Text Available Contact surveillance is a valuable strategy for controlling leprosy. A dynamic cohort study of leprosy contacts was initiated in 1987 at Oswaldo Cruz Foundation. The objective of this work was to review the data on the major risk factors leading up to the infectious stage of the disease, estimate incidence rates of leprosy in the cohort and characterise the risk factors for the disease among the contacts under surveillance. The incidence rate of leprosy among contacts of leprosy patients was estimated at 0.01694 cases per person-year in the first five years of follow-up. The following factors were associated with acquiring the disease: (i not receiving the BCG vaccine, (ii a negative Mitsuda reaction and (iii contact with a patient with a multibacillary clinical form of leprosy. The contacts of index patients who had high bacilloscopic index scores > 1 were at especially high risk of infection. The following factors were associated with infection, which was defined as a seropositive reaction for anti-phenolic glicolipid-1 IgM: (i young age (< 20 years, (ii a low measured Mitsuda reaction (< 5 mm and (iii contact with an index patient who had a high bacilloscopic index. BCG vaccination and re-vaccination were shown to be protective among household contacts. The main conclusions of this study indicate an urgent need for additional leprosy control strategies in areas with a high incidence of the disease.

  17. Evaluation of Growth Status in Children with Congenital Heart Disease: A Case- Control Study

    Directory of Open Access Journals (Sweden)

    Noor Mohammad Noori

    2017-12-01

    Full Text Available Background: Children with congenital heart disease (CHD are prone to malnutrition and growth retardation. This study aimed to compare growth status between children with CHD and healthy children.                Materials and Methods: This case–control study included 310 children with CHD and 300 healthy children matched in age and gender. CHD patients grouped according to cardiac diagnosis: group 1 (n=5, cyanotic patients with pulmonary hypertension; group 2 (n=22, cyanotic patients without pulmonary hypertension; group 3 (n=43, Acyanotic patients with pulmonary hypertension; and group 4 (n=240, Acyanotic patients without pulmonary hypertension. Anthropometric measurements of weight (Kg, height (cm, and head circumference (cm were measured and recorded for both case and control groups.  Descriptive and analytical statistics were performed using the by SPSS version 21.0. Results: Weight and head circumference were significantly lower in CHD children compared to healthy children (p

  18. Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China

    Directory of Open Access Journals (Sweden)

    H.F. Ge

    Full Text Available Invasive pulmonary fungal infection (IPFI is a potentially fatal complication in patients with connective tissue disease (CTD. The current study aimed to uncover the clinical characteristics and risk factors of patients with IPFI-CTD. The files of 2186 CTD patients admitted to a single center in northern China between January 2011 and December 2013 were retrospectively reviewed. A total of 47 CTD patients with IPFI were enrolled into this study and assigned to the CTD-IPFI group, while 47 uninfected CTD patients were assigned to the control group. Clinical manifestations were recorded, and risk factors of IPFI were calculated by stepwise logistical regression analysis. Forty-seven (2.15% CTD patients developed IPFI. Systemic lupus erythematosus patients were responsible for the highest proportion (36.17% of cases with IPFI. Candida albicans (72.3% accounted for the most common fungal species. CTD-IPFI patients had significantly elevated white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fasting glucose values compared to controls (P<0.05. Cough, sputum and blood in phlegm were the most common symptoms. Risk factors of IPFI in CTD included maximum prednisone dose ≥30 mg/day within 3 months prior to infection, anti-microbial drug therapy, and interstitial pneumonia. CTD patients who have underlying interstitial pneumonia, prior prednisone or multiple antibiotics, were more likely to develop IPFI.

  19. Job decision latitude, job demands, and cardiovascular disease: a prospective study of Swedish men.

    Science.gov (United States)

    Karasek, R; Baker, D; Marxer, F; Ahlbom, A; Theorell, T

    1981-07-01

    The association between specific job characteristics and subsequent cardiovascular disease was tested using a large random sample of the male working Swedish population. The prospective development of coronary heart disease (CHD) symptoms and signs was analyzed using a multivariate logistic regression technique. Additionally, a case-controlled study was used to analyze all cardiovascular-cerebrovascular (CHD-CVD) deaths during a six-year follow-up. The indicator of CHD symptoms and signs was validated in a six-year prospective study of CHD deaths (standardized mortality ratio 5.0; p less than or equal to .001). A hectic and psychologically demanding job increases the risk of developing CHD symptoms and signs (standardized odds ratio 1.29, p less than 0.25) and premature CHD-CVD death (relative risk 4.0, p less than .01). Low decision latitude-expressed as low intellectual discretion and low personal schedule freedom-is also associated with increased risk of cardiovascular disease. Low intellectual discretion predicts the development of CHD symptoms and signs (SOR 1.44, p less than .01), while low personal schedule freedom among the majority of workers with the minimum statutory education increases the risk of CHD-CVD death (RR 6.6, p less than .0002). The associations exist after controlling for age, education, smoking, and overweight.

  20. Effect of Selenium Supplementation on Recurrent Hyperthyroidism Caused by Graves' Disease: A Prospective Pilot Study.

    Science.gov (United States)

    Wang, L; Wang, B; Chen, S R; Hou, X; Wang, X F; Zhao, S H; Song, J Q; Wang, Y G

    2016-09-01

    The effect of selenium supplementation on recurrent hyperthyroidism caused by Graves' disease is unclear. Our study aimed to assess the efficacy of selenium supplementation therapy on recurrent Graves' disease. Forty-one patients with recurrent Graves' disease were enrolled in this study. All patients received the routine treatment using methimazole (MMI), while patients allocated to the selenium group received additional selenium therapy for 6 months. The influence of selenium supplementation on the concentrations of thyroid stimulating hormone (TSH), anti-TSH-receptor antibodies (TRAb), free thyroxine (FT4), and free triiodothyronine (FT3) were assessed. The remission rate was also compared between 2 groups. There was no obvious difference in the demographic data and the levels of serum FT4, FT3, TSH, and TRAb between the 2 groups at baseline. Both FT4 and FT3 decreased more at 2 months in the selenium group than the controls, while the TSH level increased more in patients receiving selenium supplementation (pGraves' disease. Randomized trials with large number of participants are needed to validate the finding above. © Georg Thieme Verlag KG Stuttgart · New York.