WorldWideScience

Sample records for disease the ladis study

  1. Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study

    Jokinen, Hanna; Kalska, Hely; Ylikoski, Raija

    2009-01-01

    BACKGROUND: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study...... was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. METHODS: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with annual clinical and neuropsychological evaluations...... for 3 years. The subjects meeting the MRI criteria of SIVD at baseline were compared to the other subjects of the sample with linear mixed models. RESULTS: The overall level of cognitive performance over the follow-up period was inferior in multiple cognitive domains in SIVD subjects as compared...

  2. Self-perceived memory complaints predict progression to Alzheimer disease. The LADIS study

    Verdelho, Ana; Madureira, Sofia; Moleiro, Carla

    2011-01-01

    the follow-up (ß = 2.7, p = 0.008; HR = 15.5, CI 95% [2.04, 117.6]), independently of other confounders, namely depressive symptoms, WMC severity, medial temporal lobe atrophy, and global cognition status at baseline. Self perceived memory complaints did not predict vascular dementia. In the LADIS study......Memory complaints are frequent in the elderly but its implications in cognition over time remain a controversial issue. Our objective was to evaluate the risk of self perceived memory complaints in the evolution for future dementia. The LADIS (Leukoaraiosis and Disability) prospective multinational...... battery. Dementia and subtypes of dementia were classified. Self perceived memory complaints in independent elderly were collected during the interview. MRI was performed at entry and at the end of the study. 639 subjects were included (74.1 ± 5 years old, 55% women, 9.6 ± 3.8 years of schooling). At end...

  3. Self-perceived memory complaints predict progression to Alzheimer disease. The LADIS study

    Verdelho, Ana; Madureira, Sofia; Moleiro, Carla

    2011-01-01

    of follow-up, 90 patients were demented (vascular dementia, 54; Alzheimer's disease (AD) and AD with vascular component, 34; frontotemporal dementia, 2). Using Cox regression analysis, we found that self perceived memory complaints were a strong predictor of AD and AD with vascular component during...

  4. Neurological abnormalities predict disability: the LADIS (Leukoaraiosis And DISability) study

    Poggesi, A.; Gouw, A.; van der Flier, W.M.; Pracucci, G.; Chabriat, H.; Erkinjuntti, T.; Fazekas, F.; Ferro, J.M.; Blahak, C.; Langhorne, P.; O'Brien, J.; Schmidt, R.; Visser, M.C.; Wahlund, L.O.; Waldemar, G.; Wallin, A.; Scheltens, P.; Inzitari, D.; Pantoni, L.

    2014-01-01

    To investigate the role of neurological abnormalities and magnetic resonance imaging (MRI) lesions in predicting global functional decline in a cohort of initially independent-living elderly subjects. The Leukoaraiosis And DISability (LADIS) Study, involving 11 European centres, was primarily aimed

  5. Consumers’ Attitude to the Protest Against Lady Gaga’s Concert: An Exploratory Study

    Kresno Agus Hendarto

    2013-12-01

    Full Text Available Lady gaga is an American singer who has won 5 Grammy Awards. In the middle of 2012, she was requested to have concert in Jakarta with the contract value of tens billion. The concert was protested by a number of groups. The promoter had approached the pressure groups and negotiated the dressing. However, Lady Gaga’s management canceled the concert for security consideration. The objectives of the study are: (1 to explore consumers’ attitude to the protest for the cancelation of Lady Gaga’s concert; and (2 using classical conditioning and expectancy-value theory, to explain consumers’ attitude to the protest. The study used focus group to collect data. The collected data was then transcribed and analyzed by content analysis. The results show that informants’ opinions can be classified into two groups: agreement and disagreement with the protest for the cancelation of Lady Gaga’s concert. Informants either agree or disagree for some reasons. Classical conditioning theory can explain either consumer’s attitude. The difference is the object of consumers’ attitude who agreed was Lady Gaga herself, while the object of disagreement was the pressure group that sponsored the protest. The attitude of the disagreement can also be explained by expectancy-value theory.

  6. Confirmatory factor analysis of the Neuropsychological Assessment Battery of the LADIS study

    Moleiro, Carla; Madureira, Sofia; Verdelho, Ana

    2013-01-01

    analysis (CFA) was used to investigate the dimensions of a structured set of neuropsychological tests administered to a multicenter, international sample of independent older adults (LADIS study). Six hundred and thirty-eight older adults completed baseline neuropsychological, clinical, functional...... and motor assessments, which were repeated each year for a 3-year follow-up. CFA provided support for a 3-factor model. These factors involve the dimensions of executive functions, memory functions, and speed and motor control abilities. Performance decreased in most neuropsychological measures. Results...

  7. Teaching the First Ladies using Material Culture.

    Mayo, Edith P.

    2001-01-01

    Addresses two aspects of the First Lady's role that are applicable to the use of material culture in the classroom: (1) the First Lady's social role, its impact on the presidential administration, and its use as a reflection of the changing status of the nation; and (2) the First Lady's role as campaigner. (CMK)

  8. On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

    Gouw, A.A.; Flier, W.M. van der; Pantoni, L.

    2008-01-01

    BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain...... region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more...

  9. Microscopic study of weathering of white Flemish stone from the monumental Church of Our Lady in Breda, The Netherlands

    Larbi, J.A.; Hees, R.P.J. van; Naldini, S.

    2003-01-01

    This paper deals with the use of an integrated microscopic method to assist in the investigation of the causes and the extent of decay of the stones and ornaments in the gothic Clurch of Out Lady in Breda, The Netherlands. The purpose of the study was to determine whether conservation measures were

  10. Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study

    Korf, E S C; van Straaten, E C W; de Leeuw, F-E

    2007-01-01

    HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white...... matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA...... was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95...

  11. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study

    van Straaten, EC; Fazekas, F; Rostrup, Egill

    2006-01-01

    BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are associated with decline in cognition, gait, mood, and urinary continence. Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load...... between groups with and without symptoms. METHODS: We used data of 618 independently living elderly with WMH collected in the Leukoaraiosis And DISability (LADIS) study. Subjects with and without symptoms of depression, gait disturbances, urinary incontinence, and memory decline were compared with respect...... to WMH load measured qualitatively using 3 widely used visual rating scales (Fazekas, Scheltens, and Age-Related White Matter Changes scales) and quantitatively with a semiautomated volumetric technique and an automatic lesion count. Statistical significance between groups was assessed with the chi2...

  12. The Ladies' Diary

    IAS Admin

    supposing that for every time the first hand moves round, the second hand goes 10 times, ... derive the sidereal day, the synodic periods of moon and planets. Quite interestingly this has .... The daring artist took his flight,. Soaring beyond frail ...

  13. The scientist lady

    Lawrence

    stream of her life also must have been quiet, easy, un- eventful. It was not so, she ... That too when she had full support from her family. Little Kamala ... doing research work at that famous institute was a matter of course. She then applied for ... work would not be recognized until the director was satisfied about its quality and.

  14. Cleaning lady saves the day

    2009-01-01

    At lunch time on Wednesday 21 January a guest at the CERN hostel put her food in the microwave oven and switched it on. "Within seconds I smelt plastic. I looked into the oven and saw flames. I switched it off, took my food out. But the flames continued and so I ran for the door." In the corridor she ran into Jane Kiranga, a cleaning lady working for the company ISS. Without hesitation Jane picked up a portable fire extinguisher, returned to the kitchen and stopped the fire. The Fire Brigade arrived a few minutes later and only needed to ventilate the kitchen. "Jane was just in time, because the flames had not left the oven yet. Her model behaviour deserves recognition," said the team leader on duty for the CERN Fire Brigade. A few days later Jane received a gift voucher from the Prevention and Training section of the Safety Commission (photo).

  15. Dark History of Our Lady of the Slash-Knife

    John C. Dawsey

    2009-01-01

    Full Text Available In the Garden of Flowers, over the ashes of the old Slash-Knife District, live the daughters – or granddaughters and great-granddaughters – of slaves and native South-American women “lassoed in the woods”. Many consider themselves also to be the daughters of Our Lady. The juxtaposition of maternal lineages may produce a montage-like effect. Do gestures of Indians and slaves flash in the bodily innervations of Our Lady? Signs of “dark histories” of Our Lady are found in subterranean regions of symbols. On this terrain, the study of historical patterns of settlement in Piracicaba, a city of the interior of São Paulo, may require a certain type of archaeology, involving a double dislocation, from bandeirante explorers to Our Lady, and from Our Lady to Indian and slave women “lassoed in the woods”. In these substrata the gesture of a boia-fria woman who “cut a man into pieces” stirs up the shadows of a nation.

  16. A Life Dedicated to Public Service: The Lady L Story

    Maribeth P. Bentillo

    2016-05-01

    Full Text Available This study featured how a lady local politician rose to power as a barangay captain. It aimed to: describe her leadership orientation before she became a barangay captain, analyze the factors of her success stories in political leadership, extrapolate her values based on the problems/challenges met in the barangay, unveil her initiatives to address these problems, and interpolate her enduring vision for the future of the barangay. Through a biographical research design, with purposive sampling, a key female informant named as Lady L was chosen with the sole criteria of being a female Barangay Captain of Cebu City. Interview guides were utilized in the generation of Lady L’s biographic information about her political career.Lady L’s experiences in waiting for the perfect time and working in the private sector destined her to have a successful political career enhanced with passion and family influence. Encountering problems concerning basic education and unwanted migrants in Barangay K did not discourage her choice to run for re-election, because of her dedication to public service. Her ways to reach out and collaborate with welfare groups mitigate the problems of parental neglect and informal settlers in her barangay. The story of Lady L implies that in Cebu City, issues arise as a result of the practice of partisan politics, gender issues have minor bearing, and she envisioned a healthy and welleducated barangay, with an improved wellness and child care development.

  17. TROPHIC RELATIONS OF LADY BEETLES (COLEOPTERA, COCCINELLIDAE OF THE URALS

    Z. I. Tyumaseva

    2016-05-01

    Full Text Available The article contains the study of the trophic relations of the lady beetles living in the Urals. The study allocates three ecological groups depending on the peculiarities of the beetles and larvae nutrition: phytophages, micetophages, and entomophages-predators. We have revealed 66 species of lady birds-predators and two species-phytophages: Subcoccinella vigintiquatuorpunctata (Linnaeus, 1758 and Bulaea lichatschovii (Hummel, 1827. In the group of obligatory micetophages in the Urals we registered the representatives of the tribe Halyziini, it is Halyzia sedecimguttata (Linnaeus, 1758 and Psyllobora vigintiduopunctata (Linnaeus, 1758.

  18. Firm Risk and Performance: The Role of Corporate Governance in Dutch Lady Malaysia

    Alyamutty, siti Nasirah

    2017-01-01

    The objective of this paper to characterize some indicators of overall performance of Dutch Lady Malaysia with specific risk factors and macroeconomics factors (GDP, inflation rate) on return on assets (profitability). The information was collected from Dutch Lady Malaysia annual report for five consecutive year (2011-2015). A correlation model comprising dependent variable (ROA) and numerous independent variables was used to analyse performance of Dutch Lady Malaysia. This study empirical re...

  19. Neuropsychological Predictors of Dementia in a Three-Year Follow-Up Period: Data from the LADIS Study

    Madureira, S.; Verdelho, A.; Moleiro, C.; Ferro, J.M.; Erkinjuntti, T.; Jokinen, H.; Pantoni, L.; Fazekas, F.; van der Flier, W.M.; Visser, M.; Waldemar, G.; Wallin, A.; Hennerici, M.; Inzitari, D.

    2010-01-01

    Background: White matter changes (WMC) are related to cognitive deficits and dementia. Our aim was to determine the extent to which the performance in neuropsychological tests would be able to predict the clinical diagnosis of dementia. Methods: The LADIS (Leukoaraiosis and Disability) is a

  20. Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study.

    Frederiksen, Kristian Steen; Verdelho, Ana; Madureira, Sofia; Bäzner, Hansjörg; O'Brien, John T; Fazekas, Franz; Scheltens, Philip; Schmidt, Reinhold; Wallin, Anders; Wahlund, Lars-Olof; Erkinjunttii, Timo; Poggesi, Anna; Pantoni, Leonardo; Inzitari, Domenico; Waldemar, Gunhild

    2015-07-01

    Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes (ARWMC). Data from the Leukoaraiosis And DISability (LADIS) study, a multicenter, European prospective cohort study aimed at examining the role of ARWMC in transition to disability, was used. Subjects in the LADIS study were clinically assessed yearly for 3 years including MRI at baseline and 3-year follow-up. Physical activity was assessed at baseline, and cognitive compound scores at baseline and 3-year assessment were used. Two-hundred-eighty-two subjects (age, y (mean (SD)): 73.1 (± 5.1); gender (f/m): 164/118); MMSE (mean (SD)): 28.3 (± 1.7)) who had not progressed to MCI or dementia, were included. Multiple variable linear regression analysis with baseline MMSE, education, gender, age, stroke, diabetes and ARWMC rating as covariates revealed that physical activity was associated with better scores at baseline and 3-year follow-up for executive function (baseline: β: 0.39, 95% CI: 0.13-0.90, p = 0.008; follow-up: β: 0.24, 95% CI: 0.10-0.38, p = 0.001) and processing speed (baseline: β: 0.48, 95% CI: 0.14-0.89, p = 0.005; follow-up: β: 0.15, 95% CI: 0.02-0.29, p = 0.02) but not memory. When including baseline cognitive score as a covariate in the analysis of 3-year follow-up scores, executive function remained significant (β: 0.11, 95% CI: 0-0.22, p = 0.04). Our findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC. Copyright © 2014 John Wiley & Sons, Ltd.

  1. Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study.

    Verdelho, Ana; Madureira, Sofia; Moleiro, Carla; Ferro, José M; O'Brien, John T; Poggesi, Anna; Pantoni, Leonardo; Fazekas, Franz; Scheltens, Philip; Waldemar, Gunhild; Wallin, Anders; Erkinjuntti, Timo; Inzitari, Domenico

    2013-11-01

    Depressive symptoms (DS) have been associated with increased risk of cognitive decline. Our aim was to evaluate the longitudinal influence of DS on cognition in independent older people, accounting for the severity of white matter changes (WMC). The LADIS (Leukoaraiosis And DISability in the elderly) prospective study evaluated the impact of WMC on the transition of independent older subjects into disability. Subjects were evaluated annually over a 3 year period with a comprehensive clinical and neuropsychological evaluation. Previous episodes of depression and current DS were assessed during each interview. Severity of DS was assessed using the self-rated 15 item Geriatric Depression Scale. A neuropsychological battery and clinical criteria for cognitive impairments were applied in all clinical visits, and cognitive compound measures were made based on neuropsychological results. MRI was performed at baseline and at year 3. 639 subjects were included (74.1 ± 5 years old, 55% women, 9.6 ± 3.8 years of schooling). Dementia was diagnosed in 90 patients and cognitive impairment not dementia in 147 patients at the last clinical evaluation. DS were an independent predictor of cognitive impairment (dementia and not dementia) during follow-up, independent of the effect of the severity of WMC, medial temporal lobe atrophy, age, education or global cognitive function at baseline. DS are associated with an increase risk of cognitive decline, independent of the effect of WMC, probably due to an additive or synergistic effect. In this context, DS probably represent a subtle ongoing organic dysfunction.

  2. The Trait Lady Speaks Up

    Culham, Ruth

    2006-01-01

    The acknowledged expert on the 6+1 traits of writing explains what the traits are and what they are not: The traits are not a curriculum; they are part and parcel of the writing process; they are a model, not a program; they are not a prepackaged replacement for teaching writing; and they are the language of the writing workshop. The author…

  3. White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study

    Ryberg, C.; Rostrup, E.; Sjöstrand, Karl

    2008-01-01

    BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly ...

  4. Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study

    Blahak, C; Baezner, H; Pantoni, L

    2009-01-01

    non-disabled individuals with reported falls was analysed, using the cross sectional data of the Leukoaraiosis and Disability (LADIS) study. Detailed anatomical distributions of ARWMC assessed by MRI studies were analysed with respect to falls and balance performance. RESULTS: The severity of global...... ARWMC was significantly associated with a history of falls in the year prior to study inclusion (22.2% in the mild, 31.6% in the moderate and 37.3% in the severe ARWMC group according to the Fazekas scale; p = 0.002). Analysing the anatomical distribution of ARWMC, using the semiquantitative Scheltens...

  5. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

    Ryberg, C; Rostrup, E; Paulson, O B

    2011-01-01

    ) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive......The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS...

  6. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

    Ryberg, C; Rostrup, E; Paulson, O B

    2011-01-01

    The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS......) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive...

  7. "Lady is in Heaven!" Study on the Treatment Pronoun use in Clothing Stores' Female

    Fabio Antonialli

    2015-06-01

    Full Text Available An important factor for customer satisfaction is the quality of service. In the context of small businesses, such as small clothing shops, this importance is not always taken into account. The clothing sector is connected to the changes in social relations, is rich in symbolic content, allowing the observation of expressive aspects of material culture, as well as the use of treatment pronouns mainly 'you' and 'madam'. In this sense, the aim of this study was to identify the consumers opinion in relation to the treatment pronoun used by employees in female clothing stores. Data were computed and processed using SPSS software. Techniques of descriptive statistics (frequency distribution and cross tabulations, nonparametric tests (chi-square and multivariate techniques such as cluster analysis and discriminant analysis were used. It was observed that, especially for the group of women aged between 30 and 40 years the use of the pronoun 'madam' can lead to dissatisfaction and even purchase abandonment. Also, clothing can be seen as means of status and age, conveying meanings and allowing visual identification of the class and age of the wearer. Moreover, the paper contributes in order to instruct managers and training teams.

  8. Association of gait and balance disorders with age-related white matter changes: the LADIS study

    Baezner, H.; Blahak, C.; Poggesi, A.

    2008-01-01

    : 10.2 +/- 2.1 in the mild, 9.9 +/- 2.0 in the moderate, 8.9 +/- 2.6 in the severe group; p p ... was best in individuals with mild ARWMC (single leg stance time: 18.9 +/- 10.8 seconds) compared with moderate and severe ARWMC (16.4 +/- 10.8 and 13.6 +/- 11.2 seconds) (p

  9. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study

    van Straaten, EC; Fazekas, F; Rostrup, Egill

    2006-01-01

    and Mann-Whitney tests. In addition, the punctate and confluent lesion type with comparable WMH volume were compared with respect to the clinical data using Student t test and chi2 test. Direct comparison of visual ratings with volumetry was done using curve fitting. RESULTS: Visual and volumetric...

  10. "Unnatural Deeds Do Breed Unnatural Troubles": A Study of Lady Macbeth's Cruelty

    Rahman, Muhammad Safiur; Tajuddin, Mohammad

    2015-01-01

    The study of evil is one of the recurrent themes in the plays of Shakespeare. In "Macbeth," the playwright presents different dimensions of evil. The aim of this paper is to locate and examine the origin of evil in Lady Macbeth--whether evil is in her nature or not. Macbeth addresses her as "dearest partner of greatness",…

  11. The Lady Film: Gender at The Roots of Struggle for Democracy

    Ichsani, Nurul

    2017-01-01

    - the lady film presented as a film advertising the women's struggle for bitmese independence and democracy. As a medium of communication, The lady Film indeed compresis variety of language lement both verbal and non verbal

  12. Jovanka Broz and fashion: the collection of the first lady

    Mirjana Menković

    2016-01-01

    The paper showcases a part of the collection of the first lady of SFRY, Jovanka Broz, captured in photographs taken between 1953 and 1980. The issue of the lack of primary sources is considered – the lack of objects and explicit attitudes of the first lady herself, with the goal of offering a methodological approach through which this deficiency could be overcome. The paper uses the method of chronological tracking of political events, trends in the world of fashion and events in the fashion ...

  13. Hedgehog pathway activity in the LADY prostate tumor model

    Kasper Susan

    2007-03-01

    Full Text Available Abstract Background Robust Hedgehog (Hh signaling has been implicated as a common feature of human prostate cancer and an important stimulus of tumor growth. The role of Hh signaling has been studied in several xenograft tumor models, however, the role of Hh in tumor development in a transgenic prostate cancer model has never been examined. Results We analyzed expression of Hh pathway components and conserved Hh target genes along with progenitor cell markers and selected markers of epithelial differentiation during tumor development in the LADY transgenic mouse model. Tumor development was associated with a selective increase in Ihh expression. In contrast Shh expression was decreased. Expression of the Hh target Patched (Ptc was significantly decreased while Gli1 expression was not significantly altered. A survey of other relevant genes revealed significant increases in expression of Notch-1 and Nestin together with decreased expression of HNF3a/FoxA1, NPDC-1 and probasin. Conclusion Our study shows no evidence for a generalized increase in Hh signaling during tumor development in the LADY mouse. It does reveal a selective increase in Ihh expression that is associated with increased expression of progenitor cell markers and decreased expression of terminal differentiation markers. These data suggest that Ihh expression may be a feature of a progenitor cell population that is involved in tumor development.

  14. The main altarpiece of Our Lady of the Elms church in Torre de Juan Abad, Spain: technical study and condition state

    Rosario Llamas

    2013-01-01

    Full Text Available The altarpiece of the church of Our Lady of the Elms, in Campo de Montiel, attributed to Francisco Cano, is a unique masterpiece that represents the essence of the Mannerism or Late Renaissance in the region. Its technical study is one of the objectives of this article that seeks to explain the constructive aspects and identify the materials (wood species, pigments and binders and the techniques used. Simultaneously, we have characterized its current state of preservation, describing in detail the problems identified, both structurally and in terms of the polychromy. We have tried to revalue an important work that got to survive the events of the Spanish Civil War. Generally speaking, it is unpublished information that has been collected and presented here.

  15. Professor Goes Gaga: Teaching Lady Gaga and the Sociology of Fame

    Deflem, Mathieu

    2013-01-01

    This paper presents an account of the conditions and consequences of a university-level teaching experience in the sociology of fame centered on the case of Lady Gaga. When the course "Lady Gaga and the Sociology of the Fame" at the University of South Carolina was announced in the autumn of 2010, it became the number-one Lady Gaga news…

  16. Aphid facultative symbionts reduce survival of the predatory lady beetle Hippodamia convergens

    2014-01-01

    Background Non-essential facultative endosymbionts can provide their hosts with protection from parasites, pathogens, and predators. For example, two facultative bacterial symbionts of the pea aphid (Acyrthosiphon pisum), Serratia symbiotica and Hamiltonella defensa, protect their hosts from parasitism by two species of parasitoid wasp. Previous studies have not explored whether facultative symbionts also play a defensive role against predation in this system. We tested whether feeding on aphids harboring different facultative symbionts affected the fitness of an aphid predator, the lady beetle Hippodamia convergens. Results While these aphid faculative symbionts did not deter lady beetle feeding, they did decrease survival of lady beetle larvae. Lady beetle larvae fed a diet of aphids with facultative symbionts had significantly reduced survival from egg hatching to pupation and therefore had reduced survival to adult emergence. Additionally, lady beetle adults fed aphids with facultative symbionts were significantly heavier than those fed facultative symbiont-free aphids, though development time was not significantly different. Conclusions Aphids reproduce clonally and are often found in large groups. Thus, aphid symbionts, by reducing the fitness of the aphid predator H. convergens, may indirectly defend their hosts’ clonal descendants against predation. These findings highlight the often far-reaching effects that symbionts can have in ecological systems. PMID:24555501

  17. The American Woman Series: Gender and Class in "The Ladies' Home Journal," 1897.

    Kitch, Carolyn

    1998-01-01

    Contributes to (and draws on) journalism history, mass-culture studies, and women's history in a rhetorical analysis of a series of six full-page illustrations titled "The American Woman" run in 1897 in "The Ladies' Home Journal." Reveals how class and gender issues intersected and underscored the role of the mass media in…

  18. Mariological paintings in the Chapel of Our Lady's Tomb in the Kalwaria Zebrzydowska compound. From studies on the reception of graphics in Polish 17th century painting

    Janina Dzik

    2008-12-01

    Full Text Available The Chapel of Our Lady's Tomb in Brody, complete with valuable interior furnishing, in terms of history and territory belongs to the architectural landscape concept of the Marian- and Passion-themed compound in Kalwaria Zebrzydowska. In the fields of the late-Renaissance choir parapet and the galleries of the chapel there are a series of paintings showing hitherto unspecified Marian themes. The items have never been referred to in literature on Kalwaria or mentioned in guidebooks or maintenance records. The article analyses, in a broad context, the symbolism of 37 Marian scenes presenting Mary and symbolic objects (e.g. a heart, a building, a garden.

  19. Dominance of the multicoloured Asian lady beetle Harmonia axyridis in an undisturbed wild meadow ecosystem

    Élise Bélanger

    2011-12-01

    Full Text Available Fifteen years after its arrival in Quebec (Canada, the multicoloured Asian lady beetle Harmonia axyridis (Pallas 1773 (Coleoptera: Coccinellidae has become one of the dominant coccinellid species in agricultural, forested and urban areas. Several studies conducted in North American agricultural ecosystems show that the arrival of H. axyridis and other exotic coccinellid species was followed by decreases in the populations of native coccinellid species. In this study, the abundances of H. axyridis and other native and exotic species were determined in an undisturbed wild meadow located in a protected area. In 2009 and 2010, mainly Solidago canadensis L. (Asteraceae and Asclepias syriaca L. (Asclepiadaceae infested with aphids were surveyed. A total of 1522 individuals, belonging to seven different species, were recorded. In 2009, on all the plants monitored, H. axyridis was clearly the dominant species (69% of the coccinellid assemblage. In addition, this exotic species constituted 84% of the coccinellid assemblage, including Propylea quatuordecimpunctata (L. and Coccinella septempunctata (L. It is likely the dominance of the eurytopic Asian lady beetle in agricultural, forested, urban and undisturbed open ecosystems, poses a threat to native lady beetles. These results also provide evidence that undisturbed wild meadow ecosystems will not constitute a natural refuge from Harmonia axyridis for native species of lady beetles.

  20. Callosal tissue loss parallels subtle decline in psychomotor speed. A longitudinal quantitative MRI study. The LADIS Study

    Jokinen, H.; Frederiksen, K.S.; Garde, E.; Skimminge, A.; Siebner, H.; Waldemar, G.; Ylikoski, R.; Madureira, S.; Verdelho, A.; van Straaten, E.C.W.; Barkhof, F.; Fazekas, F.; Schmidt, R.; Pantoni, L.; Inzitari, D.; Erkinjuntti, T.

    2012-01-01

    Cross-sectional studies have suggested that corpus callosum (CC) atrophy is related to impairment in global cognitive function, mental speed, and executive functions in the elderly. Longitudinal studies confirming these findings have been lacking. We investigated whether CC tissue loss is associated

  1. Callosal tissue loss parallels subtle decline in psychomotor speed. A longitudinal quantitative MRI study. The LADIS Study

    Jokinen, Hanna; Frederiksen, Kristian S; Garde, Ellen

    2012-01-01

    in a compound measure of cognitive speed and motor control, but not in those of executive functions, memory, or global cognitive function. Total CC area and midbody remained significant predictors of speed also after adjusting for baseline WML volume, WML progression, and global brain atrophy. However......, the relationship between anterior CC and speed performance was mediated by WML volume. In conclusion, the overall and regional rate of CC tissue loss parallels longitudinal slowing of psychomotor performance. The adverse effect of CC tissue loss on psychomotor function may be driven by altered interhemispheric...

  2. Prof. Elizaveta Karamihailova - The first lady of the Bulgarian physics (The contributions of prof. E. Karamihailova in radioactive studies)

    Balabanov, N.; Stoeva, M.; Lazarova, P.

    2012-01-01

    Prof. Elizaveta Karamihailova (1897-1968) is the first Bulgarian nuclear physicist and the first Bulgarian woman with an academic degree. Prof. Karamihajlova spent a significant period of time working at the Radium Institute in Vienna (1923-1935) and at the Cavendish Laboratory in Cambridge (1935-1939). She studies the nuclear reactions and the most up-to-date problems of the nuclear physics during the 1930's - neutron discovery, artificial radioactivity, split of atom nuclei. Following her return in Bulgaria (1939), E. Karamihailova continues the studies of Prof. P. Penchev to measure radioactivity of natural objects such as drinking and mineral water, soil, rocks, mud-curing. She also studies the radioactive pollution of the uranium mining regions, radioactivity due to nuclear tests. She is the founder of the first radiation protection activities in Bulgaria. (authors)

  3. Jovanka Broz and fashion: the collection of the first lady

    Mirjana Menković

    2016-03-01

    Full Text Available The paper showcases a part of the collection of the first lady of SFRY, Jovanka Broz, captured in photographs taken between 1953 and 1980. The issue of the lack of primary sources is considered – the lack of objects and explicit attitudes of the first lady herself, with the goal of offering a methodological approach through which this deficiency could be overcome. The paper uses the method of chronological tracking of political events, trends in the world of fashion and events in the fashion industry, as well as statements by participants and witnesses of certain events. Through comparison of these three aspects, we indirectly arrive at a view of the relationship of Jovanka Broz to clothing and fashion, as well as to a view of the key influences of the first lady’s collection on the fashion choices of the political elite and the fashion industry of SFR Yugoslavia. Jovanka Broz’s public appearance changed over time, from a careful selection of photographs without personal comment, through the recording of statements on formal occasions, to giving interviews to chosen journalists on specific topics – these changes are noted in the paper. It can be concluded that the fashion choices of Jovanka Broz were, first and foremost, aligned with the protocols demanded by international diplomacy, as well as that Jovanka Broz herself approached this demands with the utmost diligence, as well as personal attitude.

  4. Deterioration of Gait and Balance over Time: The Effects of Age-Related White Matter Change - The LADIS Study

    Kreisel, S.H.; Blahak, C.; Bazner, H.; Inzitari, D.; Pantoni, L.; Poggesi, A.; Chabriat, H.; Erkinjuntti, T.; Fazekas, F.; Ferro, J.M.; Langhorne, P.; O'Brien, J.; Scheltens, P.; Visser, M.C.; Wahlund, L.O.; Waldemar, G.; Wallin, A.; Hennerici, M.G.

    2013-01-01

    Background: Cross-sectional studies have shown an association between the severity of age-related white matter change (ARWMC) and lower body motor function. However, the association between prevalent ARWMC and incident deterioration of balance and gait remains insufficiently investigated. This study

  5. The Modern First Lady and Public Policy: From Edith Wilson through Hillary Rodham Clinton.

    Black, Allida M.

    2001-01-01

    Discusses the role in and influence on public policy of twentieth century First Ladies including Edith Roosevelt, Helen Taft, Ellen Wilson, Edith Wilson, Florence Harding, Lou Henry Hoover, Eleanor Roosevelt, Jacqueline Kennedy, Lady Bird Johnson, Rosalynn Carter, Nancy Reagan, Barbara Bush, and Hillary Rodham Clinton. (CMK)

  6. Women Doctors and Lady Nurses: Class, Education, and the Professional Victorian Woman.

    Heggie, Vanessa

    2015-01-01

    The lives of the first women doctors in Britain have been well studied by historians, as have the many debates about the right of women to train and practice as doctors. Yet the relationship between these women and their most obvious comparators and competitors-the newly professionalized hospital nurses-has not been explored. This article makes use of a wide range of sources to explore the ways in which the first lady doctors created "clear water" between themselves and the nurses with whom they worked and trained. In doing so, it reveals an identity that may seem at odds with some of the clichés of Victorian femininity, namely that of the intelligent and ambitious lady doctor.

  7. "Letters to a lady": questions of gender and the dissemination of Darwinism in Brazil

    Moema de Rezende Vergara

    Full Text Available Recent works on the history of scientific dissemination in Brazil have practically ignored the category of gender in their analysis. Thus, this article is intended to contribute to the content of a study of a specific practice of scientific disclosure of the 1800s, as exemplified by"Letters to a lady" written by Rangel S. Paio and published in the "O Vulgarizador". In this case, the concept of gender makes it possible to understand the tensions between the masculine and feminine appearing in a series of letters meant for purposes of scientific dissemination, in which the author himself anticipated their gender conten, insofar as he directed his attention to a public of 'ladies' in the Second Monarchical reign in Brazil.

  8. The Contested White Lady: A Critique of New Zealand Cultural Heritage Politics

    Lindsay Neill

    2012-10-01

    Full Text Available This article critiques New Zealand’s cultural heritage politics by positing that vernacular items, like an iconic eatery called the White Lady, does not meet the legislative criteria enabling cultural heritage status. If vernacular artefacts, including ‘kiwiana’, are to be integrated within cultural heritage, then changes within legislation, definitions and participant preconceptions are necessary. This study argues that cultural heritage is dominated by artefacts and historic places; that ‘kiwiana’ and other vernacular items of social history, practice and tradition are relegated. Items of ‘kiwiana’ act as touchstones of identity for New Zealanders. Therefore, their omission distorts the view of New Zealand’s cultural heritage. The application of cultural heritage status to the White Lady is important because of its transcendence of time and social change, its aesthetic, and also because of its present-day hospitality offering.

  9. Urinary complaints in nondisabled elderly people with age-related white matter changes: The Leukoaraiosis And DISability (LADIS) Study

    Poggesi, A.; Pracucci, G.; Chabriat, H.; Erkinjuntti, T.; Fazekas, F.; Verdelho, A.; Hennerici, M.; Langhorne, P.; O'Brien, J.; Scheltens, P.; Visser, M.C.; Crisby, M.; Waldemar, G.; Wallin, A.; Inzitari, D.; Pantoni, L.

    2008-01-01

    OBJECTIVES: To investigate, in a cohort of nondisabled elderly people, the association between urinary complaints and severity of age-related white matter changes (ARWMC). DESIGN: Cross-sectional data analysis from a longitudinal multinational study. SETTING: The Leukoaraiosis And DISability Study,

  10. Lady luck the theory of probability

    Weaver, Warren

    1982-01-01

    ""Should I take my umbrella?"" ""Should I buy insurance?"" ""Which horse should I bet on?"" Every day ― in business, in love affairs, in forecasting the weather or the stock market questions arise which cannot be answered by a simple ""yes"" or ""no."" Many of these questions involve probability. Probabilistic thinking is as crucially important in ordinary affairs as it is in the most abstruse realms of science. This book is the best nontechnical introduction to probability ever written. Its author, the late Dr. Warren Weaver, was a professor of mathematics, active in the Rockefeller and Sloa

  11. Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study

    Frederiksen, K.S.; Verdelho, A.; Madureira, S.; Bazner, H.; O'Brien, J. T.; Fazekas, F.; Scheltens, P.; Schmidt, R.; Wallin, A.; Wahlund, L.O.; Erkinjunttii, T.; Poggesi, A.; Pantoni, L.; Inzitari, D.; Waldemar, G.

    2015-01-01

    Objectives Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes

  12. Rheumatic disease in a Nigerian lady with sarcoidosis: Case report ...

    She had multiple joint pains, fever, oral ulcers and weight loss with associated anorexia. She developed significant hair loss, fatigue, redness of the eyes; with poor vision, and hearing impairment of about 6 years duration at the time of presentation. Essential findings were those of hearing impairment and a few crepitations ...

  13. Neuropsychological predictors of dementia in a three-year follow-up period: data from the LADIS study

    Madureira, Sofia; Verdelho, Ana; Moleiro, Carla

    2010-01-01

    White matter changes (WMC) are related to cognitive deficits and dementia. Our aim was to determine the extent to which the performance in neuropsychological tests would be able to predict the clinical diagnosis of dementia.......White matter changes (WMC) are related to cognitive deficits and dementia. Our aim was to determine the extent to which the performance in neuropsychological tests would be able to predict the clinical diagnosis of dementia....

  14. Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study

    Firbank, M.J.; Teodorczuk, A.; van der Flier, W.M.; Gouw, A.A.; Wallin, A.; Erkinjuntti, T.; Inzitari, D.; Wahlund, L.O.; Pantoni, L.; Poggesi, A.; Pracucci, G.; Langhorne, P.; O'Brien, J. T.

    2012-01-01

    Background: Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear. Aims: To investigate the relationship between baseline and incident depression and progression of white matter changes. Method: In a longitudinal multicentre

  15. Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study

    Poggesi, A.; Gouw, A.A.; van der Flier, W.M.; Pracucci, G.; Chabriat, H.; Erkinjuntti, T.; Fazekas, F.; Ferro, J.M.; Hennerici, M.; Langhorne, P.; O'Brien, J. T.; Visser, M.C.; Wahlund, L.O.; Waldemar, G.; Wallin, A.; Scheltens, P.; Inzitari, D.; Pantoni, L.

    2013-01-01

    Cerebral white matter changes (WMC) are associated with motor, cognitive, mood, urinary disturbances, and disability, but little is known about the prevalence of neurological signs in patients with these brain lesions. We assessed the presence and occurrence of neurological abnormalities over a

  16. Ibsen's mermaid in China: adapting The lady from the sea for the traditional Yue theatre

    Terry Siu-han Yip

    2015-02-01

    Full Text Available Ibsen has created Ellida Wangel in The Lady from the Sea as a “mermaid” stranded on land, feeling trapped in her marriage with Dr Wangel and suffocated by her restrictive gender roles as wife and step-mother. The play focuses on Ellida the dying mermaid’s process of individuation as she struggles to seek happiness, freedom and self-fulfilment in life. Through Ellida’s entangled relationship with the Stranger and her husband, Ibsen has created a living “mermaid”, who enables him to explore gender relations, individual freedom and choice, as well as the liberation of the self.             However, when The Lady from the Sea was transposed from Norway to China and adapted for the traditional Chinese theatre, the Chinese Yue theatre in this case, Ellida had undergone drastic changes in order to suit the traditional Yue theatregoers’ expectations and taste, as well as to fit the socio-cultural norm of traditional Yue opera.             Instead of examining those technical alterations such as rearrangement of scenes (Ye, 2011, 20, the use of symbols (Wu, 2011, 80, the setting (Wu, 2011, 78, or theatrical performance and devices (Qing Yun, 2010, 32 adopted in the Chinese operatic adaptation of The Lady from the Sea, this article focuses on the cultural re-presentation of Ellida and the re-constitution of her character, the purpose of which is to make her plausible as a Chinese woman on the traditional Yue stage. A close study of the cultural transformation of Ellida and her re-orientation on the traditional Yue stage adaptation will enable the reader to better understand the Chinese cultural emphasis on didacticism, Confucian morality and propriety in traditional drama and theatre, as well as the difficulties involved in transporting Ibsen’s mermaid to the Chinese traditional Yue stage.

  17. Regulatory Bodies: Dramatic Creativity, Control and the Commodity of Lady Audley's Secret

    Kate Mattacks

    2009-04-01

    Full Text Available 'Lady Audley's Secret' resonates with a sense of theatricality grounded in the eponymous heroine's propensity for visual tactics to attract an audience. Repositioning the dramatic exchange between actress and audience within the domestic sphere sensitised the reader to the question of diagnosing morally degenerative artificiality whilst involving the reader in the complicit act of encouraging Lady Audley's performance through consumer demand. This complex relationship between consumerism, theatre and society saw Lady Audley's figure assume an iconic status, but little has been written on the creative interplay between the novel and the theatre itself. Beginning with the way in which aspiring actresses used Lady Audley as a model to display their histrionic variety, I argue that the theatre used her character to engage with the complex connections between drama and commodity culture. Her autophagy in favour of a false identity provided a model for actresses to visualise self-commodification whilst highlighting the tension between the material practices of the theatre and the materiality of commodity culture. The drive for regulation of the theatrical medium finds its locus in the licensing text/published acting edition of William E. Suter's 'Lady Audley's Secret' (1863. Here I move to show how Suter's adaptation functioned as a site where the state regulation of the theatre was explored and contested. These unauthorised images of Lady Audley's containment came to symbolise not only the regulatory processes of licensing and copyright, but also the creative exploitation of a commodity culture critiqued through the dehumanised form of Braddon's original heroine.

  18. The Lady Spaceman: Children's Perceptions of Sex-Stereotyped Occupations.

    Rosenthal, Doreen A.; Chapman, Diane C.

    1982-01-01

    Children from single-sex and coeducational schools were asked to name male and female occupants of traditionally sex-linked roles. Children's use of linguistic markers (e.g. lady doctor) was associated with labeling of female occupants of traditionally male roles and male occupants of traditionally female roles, indicating that language reflects…

  19. The Blue Lady Case and the International Issue of Ship Dismantling - Comment

    Florent Pelsy

    2008-09-01

    Full Text Available This paper focuses on the decision of the Supreme Court of India to allow the dismantling of the Blue Lady (ex France in Alang. The first part underlines that the Supreme Court of India is prioritising the commercial interest of the dismantling companies over the social and environmental concerns of the workers and the communities living in Alang. It argues that such decision goes against its 2003 judgement on ship-dismantling. It then demonstrates that the Supreme Court of India is distorting the concept of sustainable development. The second part analyses the Blue Lady case from an international perspective since most of the ships that are dismantled in India come from developed countries. It provides an overview of the Basel Convention on ship dismantling issues and a study of the Clemenceau case before the French Conseil d'Etat. It then concludes that a better control of end-of-life ships in OECD countries and a new international convention on ship-dismantling would be necessary in order to prevent environmental and social disasters in Alang.

  20. Antioxidant effect of a fermented powder of Lady Joy bean in primary rat hepatocytes.

    La Marca, Margherita; Pucci, Laura; Bollini, Roberto; Russo, Rossella; Sparvoli, Francesca; Gabriele, Morena; Longo, Vincenzo

    2015-03-01

    The role and beneficial effects of plant and food extracts against various diseases induced by oxidative stress have received much attention in recent years. Legumes are rich in bioactive compounds, and some studies suggest a correlation between their consumption and a reduced incidence of diseases. Primary cultures of rat hepatocytes were used to investigate whether and how an extract obtained from a fermented powder of bean named Lady Joy (Phaseolus vulgaris L.) is able to regulate antioxidant and detoxifying enzymes through the NRF2 pathway, inhibit NF-kB activation, and reduce H2O2-induced endoplasmic reticulum (ER) stress. All of the antioxidant and detoxifying enzymes studied were significantly up-regulated by Lady Joy treatment. Western blot showed that Nrf2 was activated by Lady Joy treatment. Also, cells treated with this fermented bean were partially protected against NF-kB activation resulting from H2O2 stress. As a link between oxidative stress and ER dysfunction is hypothesized, we verified whether Lady Joy was able to protect cells from H2O2-induced ER stress, by studying the response of the proteins CHOP, BiP and caspase 12. The results of this study show that Lady Joy can induce the Nrf2 pathway, inhibit NF-kB, and protect ER from stress induced by H2O2.

  1. White Matter Lesion Progression in LADIS

    Schmidt, Reinhold; Berghold, Andrea; Jokinen, Hanna

    2012-01-01

    BACKGROUND AND PURPOSE: White matter lesion (WML) progression has been advocated as a surrogate marker in intervention trials on cerebral small vessel disease. We assessed the rate of visually rated WML progression, studied correlations between lesion progression and cognition, and estimated sample...... sizes for clinical trials with pure WML progression vs combined WML progression-cognitive outcomes. METHODS: Those 394 participants of the Leukoaraiosis and Disability Study (LADIS) study with magnetic resonance imaging scanning at baseline and 3-year follow-up were analyzed. WML progression rating...

  2. Pursuing public and professional perception of nuclear energy with the Smithsonian Lady Godiva replica and demonstration/display

    Grundl, J.A.

    1987-01-01

    The following topics were addressed by the speaker at the Fast Burst Reactor Workshop banquet: (1) Lady Godiva and the perception of nuclear energy, (2) the question of public and professional perception of nuclear energy, (3) notions of public perception among Lady Godiva replicators, and (4) the nuclear fission chain: complete embodiment of nuclear energy

  3. Restoring the rare Kentucky lady's slipper orchid to the Kisatchie National Forest

    James P. Barnett; Kevin Allen; David Moore

    2012-01-01

    The Kentucky lady’s slipper (Cypripedium kentuckiense C.F. Reed [Orchidaceae]) is a spectacular orchid native to the southeastern US. Although its range includes much of the Southeast, it is rare due to loss of appropriate edaphic and climatic habitats. Efforts to restore this species to the Kisatchie National Forest in Louisiana were initiated by a high school student...

  4. [Student Magazine of the ESL Classes of the International Ladies' Garment Workers' Union (ILGWU).

    Alvarez, Manuel, Ed.; Zetino, Alfredo, Ed.

    This student magazine created by the English-as-a-Second-Language (ESL) classes of the International Ladies' Garment Workers' Union (ILGWU) is a collection of personal opinions, reports, and creative writing with illustrations. Each item was written as a voluntary collaboration, homework, or classwork. Items include poems, letters, accounts of…

  5. Astronauts Stefanyshyn-Piper, Lindsey and Currie greet First Lady Hillary Clinton at the Skid Strip

    1999-01-01

    First Lady Hillary Rodham Clinton is greeted by Astronauts (from left) Heidemarie M. Stefanyshyn-Piper, Steven W. Lindsey, and Nancy Jane Currie upon Mrs. Clinton's arrival at the Skid Strip at Cape Canaveral Air Station. She and her daughter, Chelsea (far right) are here to view the launch of Space Shuttle mission STS- 93, scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected to unlock the secrets of supernovae, quasars and black holes.

  6. Achalasia of the Cardia in a 21 Year old Pregnant Lady: A Case ...

    Achalasia of the cardia is a motor disorder of the lower oesophagus of unknown aetiology. It is characterized by persistent dysphagia in 82 – 100% of patients. We describe a rare case of dysphagia due to Achalasia cardia in a pregnant lady in her third trimester. Tanzania Medical Journal Vol. 23 (2) 2008: pp. 31-32.

  7. Location of lacunar infarcts correlates with cognition in a sample of non-disabled subjects with age-related white-matter changes: the LADIS study

    Benisty, S; Gouw, A A; Porcher, R

    2009-01-01

    evaluation was based on the Mini Mental Status Examination (MMSE), a modified Alzheimer Diseases Assessment Scale for global cognitive functions, and compound Z scores for memory, executive functions, speed and motor control. WMH were rated according to the Fazekas scale; the number of lacunes was assessed...... a significant negative association between the presence of lacunes in putamen/pallidum and the memory compound Z score (beta = -0.13; p = 0.038). By contrast, no significant negative association was found between cognitive parameters and the presence of lacunes in internal capsule, lobar white matter......OBJECTIVES: In cerebral small vessel disease, white-matter hyperintensities (WMH) and lacunes are both related to cognition. Still, their respective contribution in older people remains unclear. The purpose of this study is to assess the topographic distribution of lacunes and determine whether...

  8. MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study

    Jokinen, Hanna; Kalska, Hely; Ylikoski, Raija

    2009-01-01

    of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor...... slowing as well as deficits in attention and executive functions....

  9. The contribution of technology in business growth: The case of Greek ladies

    Vassilakopoulou, Angelina

    2013-01-01

    The overall image of the use of digital technology by Greek women is not that encouraging. In information communication technology companies in the Greek market, there are only few ladies in high management mainly related to HR and marketing functions. The statistics on internet use show that although its penetration to the population is growing rapidly, there is a steady 10% gap between men (55%) and women (45%) use. It also becomes obvious, in relevant market surveys, that the internet is c...

  10. Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study

    Jokinen, Hanna; Ryberg, Charlotte; Kalska, Hely

    2007-01-01

    BACKGROUND: Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions. OBJECTIVE: To investigate the role of regional corpus callosum atrophy in mental speed...... of the total corpus callosum area and its subregions with cognitive performance were analysed using multiple linear regression, controlling for volume of WMH and other confounding factors. RESULTS: Atrophy of the total corpus callosum area was associated with poor performance in tests assessing speed of mental...... processing--namely, trail making A and Stroop test parts I and II. Anterior, but not posterior, corpus callosum atrophy was associated with deficits of attention and executive functions as reflected by the symbol digit modalities and digit cancellation tests, as well as by the subtraction scores in the trail...

  11. Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities. The LADIS study

    Jokinen, Hanne; Ryberg, Charlotte; Stegmann, Mikkel Bille

    2007-01-01

    Background: Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions. Objective: To investigate the role of regional corpus callosum atrophy in mental speed...... of the total corpus callosum area and its subregions with cognitive performance were analysed using multiple linear regression, controlling for volume of WMH and other confounding factors. Results: Atrophy of the total corpus callosum area was associated with poor performance in tests assessing speed of mental...... processing - namely, trail making A and Stroop test parts I and II. Anterior, but not posterior, corpus callosum atrophy was associated with deficits of attention and executive functions as reflected by the symbol digit modalities and digit cancellation tests, as well as by the subtraction scores...

  12. The Tragedy of a Patriarchal Angel: On Lady Macbeth’s Submission to Patriarchy in Macbeth

    黄琳

    2015-01-01

    William Shakespeare(1564-1616),as Ben Jonson assured us,is "not of an age but for all time".Macbeth,one of William Shakespeare’s most important plays,is much favored by critics for its representation of the female character Lady Macbeth who is usually regarded as the "fiend-like Queen" or a super witch by Goethe.Nevertheless,other critics like Christina Leon Alfar asserted in her article "Blood will have blood: Power,Performance,and the Trouble with Gender" believe that Lady Macbeth represented gender stereotyping.Therefore,in this essay,she is represented as a perfect wife,"The Angel in the House",and the "Other" in men’s world______________。

  13. THE FIRST LADY INSTITUTE IN THE EXPERIENCE OF THE EASTERN SLAVIA

    Inna Kalita

    2016-10-01

    Full Text Available The article analyzes the First Lady Institute experience in modern eastern Slavia. The examples of gender representation from the late Soviet era and the highest level gender “defeat” in some post-Soviet states are compared. The First Lady’s presentation and self-presentation are seen as an indicator of democratic changes in the state. The accumulated experience reflects the real condition of gender issue unpopularity among some leaders of Eastern Slavonic states, so it proves the immaturity of governmental democratic systems in Russia, Belarus and Ukraine. The analyzed paradigm also reflects the decline of the family institution prestige.

  14. "The Lady in Pink: Dress and the Enigma of Gendered Space in Marcel Proust's Fiction"

    Eva Maria Stadler

    2005-06-01

    Full Text Available A study of the role of clothing as central to issues of characterization, description and historical reference in Marcel Proust's A la recherche du temps perdu. Focus on Odette de Crécy, one of the central characters in the novel, a courtesan who becomes the wife of Charles Swann but who first captivates the narrator's imagination when, as a child, he briefly sees her as a "Lady in Pink." Odette's role as a fashionable woman, as one of the best-dressed women in Parisian society, gives unity to her character. The description of her clothing, however, not only provides the occasion for an accurate recreation of contemporary dress codes. The links between clothing and a woman's body are explicitly explored in creating the character of Odette. Her femininity is defined specifically in terms of surfaces and objects and her personality seems to assume its reality from costume. Dress not only encloses her lovely appearance; it gives substance to her person and order to her life. Through the agency of dress this ordinary, even vulgar woman rises above her condition and enters a world of passion and poetry.

  15. The art of transformation: art, marriage, and freedom in The lady from the sea

    Toril Moi

    2009-12-01

    Full Text Available The play, The Lady from the Sea, sets out to provide an answer to the question: namely, what it takes for a relationship to become a marriage. In order to follow Ibsen’s analysis of this question, however, we also need to notice that the play can be read as Ibsen’s rebuff to romantic tales of female sacrifice. The play also intertwines the story of Ellida’s achievement of freedom with an investigation of art, theatre, and music, in which the main question is how painting, sculpture, and theatre can express what some critics have called the “inner mind”. --- Original in English.

  16. Ladies of News

    Milagros Socorro

    2009-12-01

    Full Text Available This essay looks around the participation of women in the history of Venezuelan Journalism, emphasizing the importance of these “ladies of news” in the development of social communication in the country: since the field practices until the teaching in Journalism and Communication Schools. With a chronicle writing, and detailing the work made by several brave women, Milagros Socorro features this important part of the Venezuelan Journalism.

  17. Pastoral Perceptions of the Learning and Developing Individual Exercise Skills (L.A.D.I.E.S.) Intervention: A Qualitative Study

    Story, Chandra R.; Gross, Tyra T.; Harvey, Idethia S.; Whitt-Glover, Melicia C.

    2017-01-01

    African-American women experience higher rates of obesity compared to other racial/ethnic groups. High levels of reported church attendance among African-Americans have led to the proliferation of faith-based health programs. Pastors can influence success for faith-based programs. The purpose of this study was to assess pastors' perceptions of the…

  18. The Lady, the Linguists, and the International Language.

    Fettes, Mark

    2001-01-01

    Discusses an extensive research program that was conducted under the auspices of the International Auxiliary Language Association, whose goal was to gather information on Esperanto, Ido, or Latino. Reviews ideological influences that instead led to creation of new hybrid language, Interlingua. (Author/VWL)

  19. The spatial distribution of age-related white matter changes as a function of vascular risk factors--results from the LADIS study

    Rostrup, E; Gouw, A A; Vrenken, H

    2012-01-01

    White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described...... associations were found for age, gender and hypertension. Different distribution patterns were found for men and women. Further, increased probability was found in association with self-reported alcohol and tobacco consumption, as well as in those with a history of migraine. It is concluded that the location...... of WMH is dependent on the risk factors involved pointing towards a regionally different pathogenesis and/or vulnerability of the white matter....

  20. Judy Collins and First Lady Hillary Clinton await the launch of STS-93

    1999-01-01

    Singer Judy Collins (left) and First Lady Hillary Rodham Clinton await the launch of Space Shuttle mission STS-93 in the Apollo/Saturn V Facility. Liftoff is scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. Judy Collins has honored the commander with a song, 'Beyond the Sky,' which was commissioned by NASA through the NASA Art Program.

  1. The urban short story cycle before Joyce: James Stephens’ Here are Ladies

    Brouckmans, Debbie

    2013-01-01

    Published ten years after George Moore’s The Untilled Field (1903) and one year before James Joyce’s Dubliners (1914), James Stephens’ Here are Ladies (1913) consists of short stories, poems and monologues. The work is not often discussed, presumably because it is rather difficult to define. It is usually classified as a collection of short stories, but this neglects the poems and monologues and fails to do justice to the thematic and formal links between the texts. Therefore, I would like to...

  2. Over-the-counter self-medication leading to intracranial hypertension in a young lady.

    Ramana Reddy, A M; Prashanth, L K; Sharat Kumar, G G; Chandana, G; Jadav, Rakesh

    2014-10-01

    Intracranial hypertension (idiopathic-IIH and secondary) is a potentially treatable condition. Although various factors such as female gender and obesity, certain drugs have been implicated as risk factors for IIH, there remains a lack of clarity in the exact causal-effect relationship. In India, self-medication by obtaining drugs over the counter due to lack of adequate drug regulation and ignorance of the public is a very common practice with a potential for severe adverse effects. We present a case of a young lady who has developed intracranial hypertension possibly due to self-medication with steroids and cyproheptadine, obtained over the counter.

  3. Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study

    Teodorczuk, A; Firbank, M J; Pantoni, L

    2010-01-01

    BACKGROUND: Growing evidence suggests that cerebral white-matter changes and depressive symptoms are linked directly along the causal pathway. We investigated whether baseline severity of cerebral white-matter changes predict longer-term future depressive outcomes in a community sample of non...... volumetrically. Depressive outcomes were assessed in terms of depressive episodes and depressive symptoms, as measured by the Geriatric Depression Scale (GDS). Subjects were clinically reassessed annually for up to 3 years. Regression models were constructed to determine whether baseline severity of white.......09) or incident depression (p=0.08). CONCLUSIONS: Our results support the vascular depression hypothesis and strongly implicate white-matter changes in the pathogenesis of late-life depression. Furthermore, the findings indicate that, over time, part of the relationship between white-matter changes and depression...

  4. Changes in the landsnail fauna of Lady Alice Island, northeastern New Zealand

    Brook, F.J.

    1999-01-01

    A small coastal dunefield on Lady Alice Island off northern New Zealand incorporates a stratigraphic record of the historic period and much if not all of the period of prehistoric Maori occupation of the island. Fossil landsnail faunas from the dunefield are closely comparable with those from present-day dune shrubland habitats and differ from contiguous hillslope forest and shrubland faunas. Three of the landsnail species are no longer extant on Lady Alice Island. Two are large species (Amborhytida tarangensis, Placostylus hongii) that are inferred to have become extinct following the introduction of kiore (Rattus exulans) to the island. Failure to find any snail shells with breakages characteristic of rat predation suggests that kiore may not have established on the island until the early 19th century. The other smaller species of landsnail (Phrixgnathus paralaomiformis) probably became extinct in the late 19th or early 20th century as a result of habitat disturbance from fires and cattle. (author). 56 refs., 5 figs., 4 tabs

  5. Dementia and the biopolitics of the biopic: from Iris to The iron lady.

    Wearing, Sadie

    2013-05-01

    This article considers the question of embodiment through a comparative analysis of two 'biopics', Iris (2001) and The Iron Lady (2011), which both feature eponymous characters that have, or had, dementia. Embodiment draws our attention to the representation of the body in the films themselves, and to the socially significant 'feelings' or affects that circulate within and are reproduced around them. Shame, disgust and aversion are socially devastating affects conventionally associated with stigmatised bodies including those of the cognitively impaired but attention to the 'feeling tone' (Ngai, 2005) in these films demonstrates that a more varied range of affects and embodied social knowledge is produced. Embodiment is thus a starting point to explore what is at stake in these films both in their authorisation of particular versions of public lives and for their significance for the cultural politics of representation in the context of explorations of personhood and dementia.

  6. Crystal clear the autobiographies of Sir Lawrence and Lady Bragg

    Thomson, Patience

    2015-01-01

    The main body of this book contains the hitherto unpublished autobiographies of both William Lawrence Bragg, an innovative scientist who won the Nobel Prize for Physics in 1915, and his wife, Alice, a Mayor of Cambridge and National Chairman of Marriage Guidance. Their autobiographies give unusual insights into the lives and times of two distinguished people and the real personalities behind their public appearance.

  7. How the Other Half Lives: Under the Arch with Lady Henry Somerset

    Paisana Joanne

    2017-10-01

    Full Text Available The reforming work of Isabella Caroline Somerset (Lady Henry Somerset 1851-1921 is largely overlooked today. Dedicated to women’s causes at home and abroad and to temperance in particular, having first-hand knowledge of the privileged and the underprivileged, this determined, multi-talented and opinionated woman uncharacteristically wrote a fictional novel, Under the Arch (1906. In the novel, London aristocrats are portrayed rubbing shoulders with slum dwellers, but there is little real connection. The problems that the social policies introduced by the Liberals from 1906-1914 would address are nevertheless highlighted. It can be no coincidence that Somerset was well acquainted with many of these politicians. The themes of relieving the poor, Christian doctrine, marriage, women’s suffrage and imperialism are addressed, although Somerset’s focus is simply on “doing good” and loving one’s neighbour

  8. Ruth Flockart and Dr Wood: A Crucial Relationship in the Development of Melbourne Methodist Ladies' College Music Program

    Jenkins, Louise

    2011-01-01

    This paper explores the notion that particular working relationships within school music programs can have a significant affect on the program's development and progress. To explore this notion the research focussed on the working relationship of a music teacher at Melbourne Methodist Ladies' College (MLC), Ruth Flockart (1891-1985) and the…

  9. The Avenging Females: A Comparative Analysis of Kill Bill Vol.1-2, Death Proof and Sympathy for Lady Vengeance

    Basak Göksel Demiray

    2012-04-01

    Full Text Available This paper provides a comparative analysis of Quentin Tarantino’s Kill Bill Vol.1-2 (2003, 2004, Death Proof (2007 and Park Chan Wook’s Sympathy for Lady Vengeance (Chinjeolhan Geumjassi, 2005. The primary objectives of this study are: (1 to reveal the gender-biases inherent to the fundamental discursive structures of the foregoing films; (2 to compare and contrast the films through an analysis of the ‘gaze(s’ and possible ‘pleasures’,  which are inherent in their narratives, in relation to Laura Mulvey’s and Carol Clover’s approaches; and (3 to distinguish Kill Bill Vol.1-2 from the foregoing two and the ‘avenging female’ clichés of the other horror/violence movies in the context of the replaced positionings of its protagonist and antagonist inherent in its distinct narrative style.

  10. Arcabas’s paintings in the Shrine of Our Lady of La Salette

    Piotr Szweda

    2016-12-01

    Full Text Available Acting under the nickname Arcabas, Jean-Marie Pirot is a contemporary French religious painter, totally unknown in Poland. Arcabas’s artistic output is enormous, albeit difficult to catalogue. Today his works can be admired in many churches in France, in other locations across Europe, as well as in North and South America, or even in distant Japan. Our article presents a synthesis of the artistic path of Arcabas as a versatile painter who likes to influence human senses by colours while looking for harmony and beauty as God’s humble follower. In his works he transfers biblical scenes to canvas, transforming them into visual art. Moreover, we analysed six Arcabas’s paintings exhibited in the cradle of the congregation of Missionaries of Our Lady of La Salette, i.e. in the shrine of Our Lady of La Salette in France: The Wedding at Cana, Mouring at Calvary, Christ Pantocrator, The Symbols of Five Evangelists, Crowned Madonna with Child Jesus, La Salette – the Encounter. The artist’s smooth transitions from the literal to the abstract, and even combining both in a single work cause Arcabas’s works to be greeted with enthusiasm on the one hand, but criticized on the other. Jean-Marie Pirot’s art is far from clear or easy to absorb; it is rather challenging and ambiguous. It holds a mystery that intrigues, invites and encourages us to look deeper. It contains strong links to traditional Christian art, both eastern and western. The painter is not satisfied with merely becoming part of the long tradition and being inspired by themes from the repertoire of the past. He is not a slave to traditional figurative art, although his works do contain references to this tradition; instead, he demonstrates his creativity, always coming up with something new. In addition, Arcabas’s output demonstrates exceptional freedom in intertwining the sacred with the profane, sometimes suggesting that the very division should be rejected. His works, including

  11. The poetic rite of rebirth in Sylvia Plath's “Lady Lazarus"

    Sandra Novkinic

    2014-12-01

    Full Text Available The aim of this paper is to demonstrate the inviolability of „female creativity” in the works of Sylvia Plath through the symbolism of death and rebirth. „Lady Lazarus” reflects Plath’s recognition that the struggle between death and rebirth must direct every aspect of poetic structure. The woman in the poem is at the same time a victim and tormentor. She is a female Lazarus who died because of great suffering that the poet equates with the suffering of the Jews who were tortured during World War II. She is a victim of male cruelty, but also a new woman who rises from the flames. Using the myth of the resurrection of the Phoenix, Sylvia Plath shows a woman who stands up against all the men who restrain her. The allusions in the poem to the biblical, historical, political and personal take the reader into the center of a personality (of a woman.

  12. Variant dialogue structures in the story by A.P. Chekhov "Lady with dog"

    Natalya V. Izotova

    2016-09-01

    Full Text Available The article analyzes the different ways of constructing dialogue communication of the characters in A.P. Chekhov’s story «Lady with the Dog», appearing in the written text space. Variant dialogue structures are means of creating both character’s plane, and the plane of the reader, as dialogues are formed only with the participation of the reader’s consciousness of the perceiver. Formation of dialogical communication takes place with the help of different ways to transfer other speech, clotting the real dialogue, incompleteness of canonical dialogical structure that makes it possible to expand the world of the character by including the reader’s perception.

  13. A System for Harvesting Eggs from the Pink-Spotted Lady Beetle

    Margaret L. Allen

    2012-01-01

    Full Text Available We describe a system for harvesting eggs from a predatory insect, the pink-spotted lady beetle, Coleomegilla maculata De Geer (Coleoptera: Coccinellidae. Adult beetles placed in square, transparent containers that included oviposition substrates hanging from the top of the cage deposited eggs on the materials provided. We harvested eggs from these substrates in quantities sufficient for either destructive sampling or synchronous development of larvae. We evaluated effects of crowding inside cages; effects of a chemical attractant on oviposition behavior; egg cannibalism. Females preferred a textured surface rather than a smooth, waxy one for laying eggs. Crowding inhibited oviposition of beetles. Presence of a chemical attractant (methyl salicylate did not significantly improve oviposition. This paper describes an inexpensive system for harvesting eggs from C. maculata. Refinement of this system should improve oviposition and reduce cannibalism.

  14. História noturna de Nossa Senhora do Risca-Faca Dark history of our Lady of the Slash-Knife

    John C. Dawsey

    2009-04-01

    Full Text Available No Jardim das Flores, sobre as cinzas do antigo bairro do Risca-Faca, vivem as filhas - ou netas e bisnetas - de escravas e "índias laçadas no mato". Muitas delas também se consideram filhas de Nossa Senhora. A justaposição das linhagens maternas pode suscitar um efeito de montagem. Nas inervações corporais de Nossas Senhoras não lampejam, também, os gestos de índias e escravas? Nos subterrâneos dos símbolos se encontram indícios de "histórias noturnas" de Nossa Senhora. Sobre esse terreno, o estudo de processos de povoamento em Piracicaba, no interior paulista, requer uma espécie de arqueologia: um duplo deslocamento, de um bandeirante povoador a Nossa Senhora, e de Nossa Senhora às índias e escravas "laçadas no mato". Nesses fundos, o gesto de uma mulher "boia-fria" que "fez picadinho de um homem" agita as sombras de uma nação.In the Garden of Flowers, over the ashes of the old Slash-Knife District, live the daughters - or granddaughters and great-granddaughters - of slaves and native South-American women "lassoed in the woods". Many consider themselves also to be the daughters of Our Lady. The juxtaposition of maternal lineages may produce a montage-like effect. Do gestures of Indians and slaves flash in the bodily innervations of Our Lady? Signs of "dark histories" of Our Lady are found in subterranean regions of symbols. On this terrain, the study of historical patterns of settlement in Piracicaba, a city of the interior of São Paulo, may require a certain type of archaeology, involving a double dislocation, from bandeirante explorers to Our Lady, and from Our Lady to Indian and slave women "lassoed in the woods". In these substrata the gesture of a boia-fria woman who "cut a man into pieces" stirs up the shadows of a nation.

  15. Ranking prediction model using the competition record of Ladies Professional Golf Association players.

    Chae, Jin Seok; Park, Jin; So, Wi-Young

    2017-07-28

    The purpose of this study was to suggest a ranking prediction model using the competition record of the Ladies Professional Golf Association (LPGA) players. The top 100 players on the tour money list from the 2013-2016 US Open were analyzed in this model. Stepwise regression analysis was conducted to examine the effect of performance and independent variables (i.e., driving accuracy, green in regulation, putts per round, driving distance, percentage of sand saves, par-3 average, par-4 average, par-5 average, birdies average, and eagle average) on dependent variables (i.e., scoring average, official money, top-10 finishes, winning percentage, and 60-strokes average). The following prediction model was suggested:Y (Scoring average) = 55.871 - 0.947 (Birdies average) + 4.576 (Par-4 average) - 0.028 (Green in regulation) - 0.012 (Percentage of sand saves) + 2.088 (Par-3 average) - 0.026 (Driving accuracy) - 0.017 (Driving distance) + 0.085 (Putts per round)Y (Official money) = 6628736.723 + 528557.907 (Birdies average) - 1831800.821 (Par-4 average) + 11681.739 (Green in regulation) + 6476.344 (Percentage of sand saves) - 688115.074 (Par-3 average) + 7375.971 (Driving accuracy)Y (Top-10 finish%) = 204.462 + 12.562 (Birdies average) - 47.745 (Par-4 average) + 1.633 (Green in regulation) - 5.151 (Putts per round) + 0.132 (Percentage of sand saves)Y (Winning percentage) = 49.949 + 3.191 (Birdies average) - 15.023 (Par-4 average) + 0.043 (Percentage of sand saves)Y (60-strokes average) = 217.649 + 13.978 (Birdies average) - 44.855 (Par-4 average) - 22.433 (Par-3 average) + 0.16 (Green in regulation)Scoring of the above five prediction models and the prediction of golf ranking in the 2016 Women's Golf Olympic competition in Rio revealed a significant correlation between the predicted and real ranking (r = 0.689, p ranking prediction model using LPGA data may help coaches and players to identify which players are likely to participate in Olympic and World competitions, based

  16. The Tragedy of a Patriarchal Angel:On Lady Macbeth’s Submission to Patriarchy in Macbeth

    黄琳

    2015-01-01

    William Shakespeare (1564-1616),as Ben Jonson assured us,is“not of an age but for all time”.Macbeth,one of William Shakespeare’s most important plays,is much favored by critics for its representation of the female character Lady Macbeth who is usually regarded as the“fiend-like Queen” or a super witch by Goethe.Nevertheless,other critics like Christina Leon Alfar asserted in her article“Blood will have blood: Power,Performance,and the Trouble with Gender” believe that Lady Macbeth represented gender stereotyping.Therefore,in this essay,she is represented as a perfect wife,“The Angel in the House”,and the“Other” in men’s world ______________.

  17. Our Lady of the Rosary in the Marian Sanctuary: Brotherhoods and Black Devotions in Salvador and the Recôncavo Baiano (Eighteenth Century

    Tânia Maria PINTO DE SANTANA

    2016-06-01

    Full Text Available Organized by Frei Agostinho de Santa Maria and published in 1722, the Marian Sanctuary and History of the Miracles image of Our Lady consist the registrations of marian invocations worshiped in Portuguese territory, made by clergymen from differents parishes in the xviii century. The ninth volume deal witch the invocations found in Bahia. In this article we mean to use this text as a study sourse for the history religious belief, as well as in the study of the Catholic religiosity history among the black people in the reconcavo baiano. The reconcavo baiano was one of the most important region of the sugar cane production in the American Portuguesa in that period where concentrated an expressive population of black people that was used in the slave labor in that production. Our analysis which has as a main objective of study Our Lady of Rosario worship in the brotherhoods and the black people’s devotions in that region. Seeking to understand at first the motivation for such worship, experienced in the context of the slavery. Subsequently we will concentrate our analysis in the aspects linked to its growth and development, such as celebrations for their Patroness, and the use of images in moments of celebrations. From here it’s necessary to comprehend how the place of the black, as a slave or a free man, marked the relations established and the differents moments of celebrations.

  18. Incorporating a Sorghum Habitat for Enhancing Lady Beetles (Coleoptera: Coccinellidae in Cotton

    P. G. Tillman

    2012-01-01

    Full Text Available Lady beetles (Coleoptera: Coccinellidae prey on insect pests in cotton. The objective of this 2 yr on-farm study was to document the impact of a grain sorghum trap crop on the density of Coccinellidae on nearby cotton. Scymnus spp., Coccinella septempunctata (L., Hippodamia convergens Guérin-Méneville, Harmonia axyridis (Pallas, Coleomegilla maculata (De Geer, Cycloneda munda (Say, and Olla v-nigrum (Mulsant were found in sorghum over both years. Lady beetle compositions in sorghum and cotton and in yellow pyramidal traps were similar. For both years, density of lady beetles generally was higher on cotton with sorghum than on control cotton. Our results indicate that sorghum was a source of lady beetles in cotton, and thus incorporation of a sorghum habitat in farmscapes with cotton has great potential to enhance biocontrol of insect pests in cotton.

  19. Effect of stress on serum lipid levels in lady health visitors and housewives

    Wattoo, F.H.; Memon, M.S.; Memon, A.N.; Wattoo, M.H.S.; Tirmizi, S.A.; Iqbal, J.

    2007-01-01

    To study the effects of stress among lady health visitors and housewives in regard to their serum total cholesterol, HDL cholesterol, and LDL cholesterol and triglyceride levels. The study was performed at the Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan during the years 2003 to 2005. Seventy lady health visitor and housewives aged between 25-40 years participated in this study and were selected from Hyderabad and its adjoining areas. Environmental, psychological and physiological stress levels were measured with likert scale. Total cholesterol, LDL cholesterol and HDL cholesterol and triglyceride levels were measured. Environmental, psychological and physiological stresses were significantly higher in housewives as compared to lady health visitors. A low level of HDL cholesterol was observed in housewives as compared to lady health visitors. The levels of total cholesterol, LDL cholesterol and triglyceride were found higher in housewives than lady health visitors. Housewives are under more stress than lady health visitors. The levels of total cholesterol, LDL cholesterol and triglyceride increases but HDL cholesterol decrease with stress. (author)

  20. Of Lady-killers and ‘Men Dressed As Women’: Soap Opera, Scapegoats and the Mexico City Police Department

    Vek Lewis

    2008-02-01

    Full Text Available Over two days in October 2005, police in Mexico City conducted a series of raids on male-to-female transgender (travesti prostitutes working in the streets. The motive of the investigation was not related to sex work at all, but rather, the hunt for a serial killer responsible for the deaths of elderly women between 2003 and 2005. With few leads apart from reports by a couple of eyewitnesses that they had seen ‘a man dressed as a woman’ enter the houses of the victims, the Chief Public Prosecutor announced that the killer could be a travesti. On January 25, 2006, thelady-killer’ was finally discovered to be neither a ‘man dressed as a woman’, nor a travesti. The suspect, a female former lucha libre wrestler, Juana Barraza, was taken into custody. In the period leading up to the October raids, Mexico’s chief television channel, Televisa, finished up the season of its popular soap, La Madrastra, with a plot line that features a man who dresses as a woman to disguise his usual male identity and kill his female victims. This paper examines the case, looking at the influence of the soap opera narrative in the profiling of travestis as suspect ‘men dressed as women’. It draws on studies of soap opera and mass media forms in Mexican society, as well as the work of transgender theory in understanding how crossgender identities are circumscribed by discourse.

  1. The Israeli–Palestinian Separation Wall and the Assemblage Theory: The Case of the Weekly Rosary at the Icon of Our Lady of the Wall

    Elisa Farinacci

    2017-06-01

    Full Text Available In this work I analyse the ethnographic case study of the icon of Our Lady of the Wall as establishing a unique ritual landscape among the cement slabs of the Israeli–Palestinian Wall separating Jerusalem from Bethlehem. Although the Wall has been widely described as a technology of occupation on one side and as a device to ensure security on the other, through Latour’s concept of assemblages I unearth its agency in developing a Christian shrine. Through a decade of weekly recitations of the Rosary along the Wall near Checkpoint 300, the Elizabethan nuns of the Caritas Baby Hospital have been invoking Mary’s help to dismantle the Wall. This weekly ritual represents both political dissent against the bordering action enacted by the Wall, as well as giving visibility to the plea of the Palestinian Christian right to live in this territory in the face of their status as an ethno-religious minority.

  2. Pop Art Trends in Lady Gaga’s Creativity

    Marina Zaytseva

    2017-02-01

    Full Text Available The article reveals the connection between the creative principles of the popular singer Lady Gaga and the cult personality of pop art – Andy Warhol. On the basis of analysis of Lady Gaga’s performance practice, the features of her performing style, formed under the influence of the aesthetics of pop art are revealed. The dynamics of formation and development of the performing style of Lady Gaga is followed.

  3. Jurassic animals and algae in the flooring of Our Lady of Sorrows Church in Poznań

    Antczak Mateusz

    2015-12-01

    Full Text Available The flooring of Our Lady of Sorrows Church in Poznań is made of Jurassic rocks from the Świętokrzyskie Mountains (also known as Holy Cross Mountains and contain abundant marine invertebrate fossils: sponges, bivalves, brachiopods, various families of cephalopods, etc. Some of them can be identified to the genus level. The fossils make it possible to describe the environment and ecosystem of the Jurassic sea and biostratigraphy of the sediment. There are also some significant inorganic structures, which suggest post-diagenetic tectonic movements.

  4. The Uncontrollable Mnemonic Fragments within Consciousness Reflecting Ophelia’s and Lady Macbeth’s Disturbed Minds

    Ekmekçioğlu Neslihan

    2015-12-01

    Full Text Available Memory plays an important role in most of Shakespeare’s plays. Shakespeare delves into the dark realms of human consciousness to reflect the disturbed minds and gnawing consciences of his characters with a profound psychological insight into the human psyche. Time, memory, madness and death seem to be the basic issues dealt with in his canon. My paper will address the uncontrollable mnemonic fragments within the human consciousness which reflect past traumas, fears and disturbances and will examine the cases of Ophelia and Lady Macbeth from a feminist reading of women.

  5. On a fast numerical tool for nuclear accidental dynamic phenomenology and application to the real time simulation of Lady Godiva

    Bindel, Laurent; Gamess, Andre; Jasserand, Frederic; Laporte, Sebastien

    2003-01-01

    This paper present a modern numerical method, implemented in a TUI-code named MacDSP, for solving any set of differential equations and in particular phenomenological accidental dynamic calculations. The speed efficiency of such an approach, thanks to the use of the hybrid-level power offered by C++ and an ad-hoc design, make it possible to construct the first kid of a family of real time simulator employing the video games technology DirectX TM : Lady Godiva Real Time Simulator. (author)

  6. Histopathological pattern of soft tissues tumors and tumour like lesions in the pathology department of lady reading hospital peshawar, pakistan

    Sajjad, M.; Ahmad, F.

    2016-01-01

    Soft tissues tumours are tumours of mesenchymal origin excluding epithelial, skeletal tissue, reticuloendothelial system, brain coverings and solid viscera of the body. The objective of this study was to know the histopathological pattern of soft tissues tumours in the Pathology Department of Lady Reading Hospital Peshawar Khyber Pakhtunkhwa Pakistan. Methods: This descriptive study was conducted on retrospective data from January 2009 to December 2013. All the soft tissues biopsy specimens were received in 10% formalin, labelled, gross performed, sections processed in alcohol, xylene, wax, block prepared, frozen, microtome sections taken and processed for H and E staining, mounted and reported by a Histopathologist. The inclusion criteria was any sufficient soft tissue tumour biopsy specimen of any age, sex, location in body whereas the exclusion criteria was autolysed biopsy specimen. A minimum of four and maximum of eight sections and 5 micron thick were taken from each specimen. Results: A total of 267 soft tissues tumours biopsy specimens were received in the pathology laboratory with age range of 01 to 75 years, with mean age of 30.68+-17.71 years. Male to female ratio was 1.13:1. Amongst the total, benign tumours were 176 (65.91%). Haemangioma, 73 (27.3%) was the commonest tumours followed by lipomas 41 (15.4%) cases. Amongst the total malignant tumours, i.e., 91 (34.08%), rhabdomyosarcoma, 35 (13.1%) was the commonest tumour followed by angiosarcoma 14 (5.2%) cases. Conclusion: Haemangioma is the commonest benign tumour and rhabdomyosarcoma is the commonest malignant tumour in this study. (author)

  7. Characteristics of the assistance to pilgrims in the National Sanctuary of Our Lady of Aparecida, São Paulo, Brazil, 2011-2014.

    Carmo, Hercules de Oliveira; Valente, Tânia Cristina Oliveira

    2017-01-01

    to describe the characteristics of the health assistance for pilgrims visiting the National Sanctuary of Our Lady of Aparecida and to investigate health care strategies in periods of peak of religious tourism. a descriptive study using outpatient medical records from 2011 to 2014, for a detailed analysis for the month of October 2014 and the operational documents for health care in periods of mass events in the medical clinic of the Sanctuary. 95,011 people were assisted in the period, 2,266 in October 2014; the higher demand for assistance was from elderly individuals (33%), women (59%), and people from the Brazilian Southeast region (79%); there were no operational documents for specific actions for this period. the large number of visitors, associated with the frequency of mass events and the absence of an operating plan, may pose a serious public health scenario for that region.

  8. Replacement of natural stone in conservation of historic buildings, Evaluation of replacement of natural stone at the church of Our Lady in Breda

    Quist, W.J.

    2009-01-01

    In this paper the decision process and the choice for specific types of natural stone for conservation purposes are investigated. Two successive 20th century conservation campaigns at the church of Our Lady in Breda are analyzed. It was specifically investigated in how far the architects involved

  9. A new species of myrmecophilous lady beetle in the genus Diomus (Coleoptera: Coccinellidae: Diomini) from Chiapas, Mexico that feeds on green coffee scale, Coccus viridis (Green) (Hemiptera: Coccidae)

    A new species of myrmecophilous lady beetle in the genus Diomus (Coleoptera: Coccinellidae: Diomini) is described from a coffee agroecosystem in Chiapas, Mexico. The new species was found preying on the green coffee scale pest, Coccus viridis (Green), tended primarily by Azteca sericeasur Longino an...

  10. Church ladies, good girls, and locas: stigma and the intersection of gender, ethnicity, mental illness, and sexuality in relation to HIV risk.

    Collins, Pamela Y; von Unger, Hella; Armbrister, Adria

    2008-08-01

    Inner city women with severe mental illness may carry multiple stigmatized statuses. In some contexts these include having a mental illness, being a member of an ethnic minority group, being an immigrant, being poor, and being a woman who does not live up to gendered expectations. These potentially stigmatizing identities influence both the way women's sexuality is viewed and their risk for HIV infection. This qualitative study applies the concept of intersectionality to facilitate understanding of how these multiple identities intersect to influence women's sexuality and HIV risk. We report the firsthand accounts of 24 Latina women living with severe mental illness in New York City. In examining the interlocking domains of these women's sexual lives, we find that the women seek identities that define them in opposition to the stigmatizing label of "loca" (Spanish for crazy) and bestow respect and dignity. These identities have unfolded through the additional themes of "good girls" and "church ladies". Therefore, in spite of their association with the "loca", the women also identify with faith and religion ("church ladies") and uphold more traditional gender norms ("good girls") that are often undermined by the realities of life with a severe mental illness and the stigma attached to it. However, the participants fall short of their gender ideals and engage in sexual relationships that they experience as disempowering and unsatisfying. The effects of their multiple identities as poor Latina women living with severe mental illness in an urban ethnic minority community are not always additive, but the interlocking effects can facilitate increased HIV risks. Interventions should acknowledge women's multiple layers of vulnerability, both individual and structural, and stress women's empowerment in and beyond the sexual realm.

  11. Never the Oval Office? From Eleanor Roosevelt to Michelle Obama—First Ladies and Their Social and Feminist Agenda

    Martina Kohl

    2017-07-01

    Full Text Available Prompted by the 2016 elections in the United States, women’s prospects in U.S. politics have received renewed attention among scholars and politically interested circles. Hillary Clinton, without any doubt one of the—if not the most qualified candidates for the Presidency ever, suffered an unexpected defeat on November 9th. Polls, experts, and the candidates were taken by surprise. Only in hindsight do critics claim to have known all along that Hillary Clinton’s defeat might have been foreseeable. As a former First Lady, Hillary Clinton belongs to a group of women in U.S. politics that at least have made it into the White House—though not as an elected representative of the administration. As different as these women have been, they all have one thing in common: the chance to shape policy.

  12. Re-Innovating. Technological research contribution in the recovery of Our Lady of Mercy Church in Baranzate

    Anna Mangiarotti

    2011-04-01

    Full Text Available The recovery project of Our Lady of Mercy Church in Baranzate, by Angelo Mangiarotti and Bruno Morassutti, with Aldo Favini for structures, built in 1956, and now in charge by Giulio Barazzetta, Anna Mangiarotti, Ingrid Paoletti, Tito Neri for structures and Giancarlo Chiesa for hvac, has requested a high technological effort in order to identify the technical options in order to ‘re-innovate’ on this building. The aim is to increase performances and internal comfort, while maintaining the original concept of the church. The deteriorated envelope will be changed with a façade envelope in steel dry assembled and a triple glazed unit high performance and with face fritted surfaced in order to reproduce the original architectural effects. Thanks to hvac, performances are radically improved.

  13. The Microsoft® Crabby Office Lady Tells It Like It Is Secrets to Surviving Office Life

    Stahl, Annik

    2009-01-01

    We all have to work for a living-so why not make that time work for you? Whether you're in a cubicle or corner office, the Crabby Office Lady shows you how to be more productive on the job so that you can really enjoy your time off the job. Humorous but practical, the lovable know-it-all reveals her secrets in this easy-to-read survival guide based on her popular column. You'll get her no-nonsense lessons to succeeding at work, as well as tips and tricks for working with Microsoft Office programs to help simplify your life. She'll give you the straight scoop-so pay attention! Crabby says, "L

  14. The first lady phenomenon:Elites, states, and the contradictory politics of women’s empowerment in the neoliberal arab world

    Sukarieh, Mayssoun

    2015-01-01

    Drawing on analysis of different sources-media analysis, policy documents, interviews, and participant observation-this article analyzes the representation of Queen Rania of Jordan and the First Lady of Syria, Asma al-Assad, and their work in civil society. An analysis of Rania and Assad helps illustrate the ways in which gender roles and representations, in the Arab and Muslim world as elsewhere, are always multiple and contradictory, varying across lines of social class and intimately conne...

  15. Lady Mary Sidney Herbert a Lady Mary Wroth: labutí píseň a imaginativní svět jako součást rodinného odkazu (Lady Mary Sidney Herbert and Lady Mary Wroth: a Swan song and Fictional World as a part of Sidneyan legacy

    Martina Kastnerová

    2017-03-01

    Full Text Available The study intends to clarify the process of forming of Sidneyan literary cult as a part of (Sidneyʼs family legacy based on the the literary activities of Sidneyʼs sister Lady Mary Sidney Herbert, countess of Pembroke, and his niece Lady Mary Wroth, daughter of his younger brother Robert. Mary Sidney Herbert throughout her literary career sings a swan song of her brother, Mary Wroth creates an imaginative world of free love choice and happy endings and her literary career is based on the well-established cult of Sidneyʼs name.

  16. The Woman Reader in the “Feminine Press” of the XIX c. A Comparative Study between Biblioteca de señoritas [Ladies´ Library] (1858-1859 and La Mujer [Woman] (1878-1881

    Cristina Gil Medina

    2016-07-01

    Full Text Available In the mid XIX century, press in Colombia began to focus on a new type of reader: women. This initiative required a new outlook in the administration of periodical publications, evidenced in their materiality, contents, editorials, topics, writing genres, among other aspects. In this way, each publication accounted for the ideological orientation that guided it, and in this way, expressed a particular conception of woman, her role in society and consequently, the figure of ideal reader that it pretended to construct.

  17. Structural analysis of jewelry from the Moche tomb of the `lady of Cao' by X-ray digital radiography

    Azeredo, S. R.; Cesareo, R.; Franco, R.; Fernandez, A.; Bustamante, A.; Lopes, R. T.

    2018-04-01

    Nose ornaments from the tomb of the `Lady of Cao', a mummified woman representative of the Moche culture and dated to the third-or-fourth century AD, were analyzed by X-ray digital radiography. These spectacular gold and silver jewels are some of the most sophisticated metalworking ever produced in ancient America. The Mochecivilization flourished along the north coast of present-day Peru, between the Andes and the Pacific Ocean, approximately between 100 and 600 AD. The Moche were very sophisticated artisans and metal smiths, being considered the finest producers of jewels and artifacts of the region. A portable X-ray digital radiography (XDR) system consisting of a flat panel detector with high resolution image and a mini X-ray tube was used for the structural analysis of the Moche jewels aiming at inferring different joining methods of the silver-gold sheets. The radiographic analysis showed some differences in the joint of the silver-and-gold sheets. Presence of filler material and adhesive for joining the silver-and-gold sheets was visible as well as silver-gold junctions without filler material (or with a material invisible in radiography). Furthermore, the technique demonstrated the advantage of using a portable XDR micro system when the sample cannot be brought to the laboratory.

  18. Long-distance autumn migration across the Sahara by painted lady butterflies: exploiting resource pulses in the tropical savannah.

    Stefanescu, Constantí; Soto, David X; Talavera, Gerard; Vila, Roger; Hobson, Keith A

    2016-10-01

    The painted lady, Vanessa cardui, is a migratory butterfly that performs an annual multi-generational migration between Europe and North Africa. Its seasonal appearance south of the Sahara in autumn is well known and has led to the suggestion that it results from extremely long migratory flights by European butterflies to seasonally exploit the Sahel and the tropical savannah. However, this possibility has remained unproven. Here, we analyse the isotopic composition of butterflies from seven European and seven African countries to provide new support for this hypothesis. Each individual was assigned a geographical natal origin, based on its wing stable hydrogen isotope (δ 2 H w ) value and a predicted δ 2 H w basemap for Europe and northern Africa. Natal assignments of autumn migrants collected south of the Sahara confirmed long-distance movements (of 4000 km or more) starting in Europe. Samples from Maghreb revealed a mixed origin of migrants, with most individuals with a European origin, but others having originated in the Sahel. Therefore, autumn movements are not only directed to northwestern Africa, but also include southward and northward flights across the Sahara. Through this remarkable behaviour, the productive but highly seasonal region south of the Sahara is incorporated into the migratory circuit of V. cardui. © 2016 The Author(s).

  19. “Too Long in Foreign Parts”?: An Asian Reception to Cosmopolitanism in Henry James’s The American and The Portrait of a Lady

    Patricia Haseltine

    2012-04-01

    Full Text Available The works of Henry James with their attention to cosmopolitanism in the late nineteenth and early twentieth centuries provide valuable insight into contemporary expectations of cultural hybridity and globalism. This paper assesses the ways students studying English as a foreign language in Taiwan read the cultural exchanges between Americans and Europeans in James’s "The American" (1877 and "The Portrait of a Lady" (1881. It places the main attention upon how students evaluate James’s characters based upon their own attitudes toward cosmopolitanism, work and leisure, and women’s independence. Informed by the travel theory of Mary Louise Pratt (2008 and Homi Bhabha’s (1994 concept of the third space, it studies the negotiation and subversion of meaning in postcolonial and reverse-colonial contexts. The analysis of student responses reveals that in this culturally hybrid reading site, the limited consciousness technique of James generates judgments of characters’ potentialities based upon the students’ own values. Reconciling the cultural oppositions in the self to become a citizen of the world remains an ideal they do not see fully realized in James’s highly conflicted characters, and, as their own partial views attest, not realizable in their own lives.

  20. Elephantiasis nostras verrucosa on the legs and abdomen with morbid obesity in an Indian lady.

    Sarma, Podila S; Ghorpade, Ashok

    2008-12-15

    Elephantiasis nostras verrucosa (ENV) of the legs and abdomen in a morbidly obese woman with multiple medical problems is reported. The diagnosis was suggested by the classical clinical features and confirmed by histopathology. The patient succumbed due to her multisystem diseases. Elephantiasis nostras verrucosa involving the abdomen is uncommon and has been reported only five times in the past.

  1. Aphid secondary symbionts do not affect prey attractiveness to two species of predatory lady beetles.

    Jennifer L Kovacs

    Full Text Available Heritable symbionts have been found to mediate interactions between host species and their natural enemies in a variety of organisms. Aphids, their facultative symbionts, and their potential fitness effects have been particularly well-studied. For example, the aphid facultative symbiont Regiella can protect its host from infection from a fungal pathogen, and aphids with Hamiltonella are less likely to be parasitized by parasitic wasps. Recent work has also found there to be negative fitness effects for the larvae of two species of aphidophagous lady beetles that consumed aphids with facultative symbionts. In both species, larvae that consumed aphids with secondary symbionts were significantly less likely to survive to adulthood. In this study we tested whether adult Harmonia axyridis and Hippodamia convergens lady beetles avoided aphids with symbionts in a series of choice experiments. Adults of both lady beetle species were as likely to choose aphids with symbionts as those without, despite the potential negative fitness effects associated with consuming aphids with facultative symbionts. This may suggest that under natural conditions aphid secondary symbionts are not a significant source of selection for predatory lady beetles.

  2. Virtuous colours for Mary. Identification of lapis lazuli, smalt and cochineal in the Andean colonial image of Our Lady of Copacabana (Bolivia)

    Tomasini, Eugenia P.; Marte, Fernando; Careaga, Valeria P.; Landa, Carlos Rúa; Siracusano, Gabriela

    2016-01-01

    The image of Our Lady of Copacabana, a gilded polychrome sculpture carved in maguey wood in 1583, is one of the most important devotions in the Americas. In former research, we have identified the use of gypsum, Armenian bole, cerussite and atacamite in its polychromy. In this study, a red sample taken from the Virgin's tunic and a blue sample extracted from the cloak have been analysed with the aim to identify both pigments and offer insights into the painting technique. Analysis by micro-Raman spectroscopy complemented with scanning electron microscopy–energy dispersive spectroscopy and high-performance liquid chromatography allowed the identification of carmine lake in the red sample. Analysis by micro-Raman spectroscopy of the surface of the blue sample and its cross section showed the presence of smalt—the blue-glass pigment—over a cerussite layer, bathed by a very thin ultramarine layer—from a probable native origin—following a pictorial tradition that would last even until the eighteenth century. This is the first time that lapis lazuli has been scientifically identified in a Spanish American colonial painted layer. This article is part of the themed issue ‘Raman spectroscopy in art and archaeology’. PMID:27799431

  3. Pattern of breast cancer experience at lady reading hospital, Peshawar

    Naeem, M.; Khan, N.; Samad, A.

    2008-01-01

    Breast Cancer is the commonest malignancy of females all over the world and second leading cause of death due to cancer among females. The aim of this Descriptive study was to see the various features of breast cancer in order to know the pattern of disease in the recent time. The study was conducted from Jan. 2007 to Dec. 2007 in Surgical C Unit, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan. Study included all patients presenting to and admitted in Surgical C Unit LRH, with carcinoma of breast during the above mentioned period. Name, age, sex, other relevant data, history and examination findings and results of histopathology and other investigations were recorded. Total of 46 patients was included in the study, out of which there were 46 female and 1 male patients. Most common age group was 40-49 years with 14 patients, followed by 50-59 years with 12 patients. Most common type of carcinoma was infiltrating ductal carcinoma with no specific features with 38 patients. Other types included 2 infiltrating ductal carcinomas of papillary type, 1 mucinous type and 1 medullary type; 3 invasive lobular carcinomas, and 1 mixed lobular and ductal carcinoma. The disease was left sided in 24 cases, right sided in 20 cases while it was bilateral in 2 cases. Upper outer quadrant of the breast was most commonly involved (n=26). There were 2 cases of stage I, 16 stage II, 20 stage III and 08 cases of stage IV disease. There were 2 cases of grade I, 16 grade II, and 28 cases of grade III. Carcinoma breast is still a common problem presenting at a young to middle age group with invasive ductal carcinoma being the commonest variant with a high grade and a late stage of presentation due to lack of screening and awareness programs. (author)

  4. Facebook marketing communications plan for Ladies Gym

    Orelma, Lilja

    2016-01-01

    Ladies Gym is a gym located in Vantaa, Finland. Until now, the company’s marketing actions have been limited to occasional e-mail newsletters, posters on the walls of the gym, and a newspaper advertisement once a year. The outcome of this thesis is a Facebook marketing communications plan that will be implemented by the company. Marketing communications and B-2-C relationship management are covered in the theoretical framework. Facebook as a marketing communications tool is covered in mor...

  5. The Study on the Thyroid Disease

    Lee, Mun Ho

    1982-01-01

    Several recent advances in our knowledge of thyroid physiology have broad application to the diagnosis and management of thyroid disorders. For in the thyroid, more than other end-ocrine organs, pathophysiology can be translated directly into the diagnosis and management of thyroid disease. Graves' disease is a syndrome including goiter with hyperthyroidism, exophthalmos and dermatopathy. The pathogenesis of Graves' disease is not yet clearly identified, but various autoantibodies to the thyroid gland and immunapathalogic studied indicate that autoimmune processes are involved in the pathogenesis of the disease. The diagnosis and management of Graves' disease are largely dependent on radionuclide technique as radioimmunoassay, radioactive iodine therapy and so on. Several laboratory tests are also developed to determine the remission of this disease including TRH stimulation test, T 3 , suppression test and detection of thyroid stimulating immunoglobulins. Autoimmune thyroiditis is almost certainly a primary immunologic disease and the incidence tends to increase recently, mainly due to the application of biopsy technique is thyroid diseases. Thyroid nodules have been a great challenge to physicians because of the possibility of malignancy. But recently, cytologic examination of thyroid aspirate provides a very simple and also reliable diagnostic method in patients with thyroid nodules. In 163 patients with thyroid nodules, only 19.3% was revealed to be malignant. Therefore cytologic examination of thyroid aspirate and thyroid biopsy should be included in the diagnosis of nodular patients prior to surgical intervention. In this paper, a comprehensive review is presented on the pathogenesis, clinical features, laboratory findings and therapeutic modalities of various thyroid diseases on the basis of over 80 researches performed during the past 20 years at radioisotope clinic, Seoul National University Hospital.

  6. Lambda-Cyhalothrin Resistance in the Lady Beetle Eriopis connexa (Coleoptera: Coccinellidae) Confers Tolerance to Other Pyrethroids.

    Torres, J B; Rodrigues, A R S; Barros, E M; Santos, D S

    2015-02-01

    Pyrethroid insecticides are widely recommended to control insect defoliators but lack efficacy against most aphid species. Thus, conserving aphid predators such as the lady beetle Eriopis connexa (Germar) is important to pest management in crop ecosystems that require pyrethroid sprays. In a greenhouse, early fourth-instar larvae and 5-day-old adults from susceptible (S) and resistant (R) E. connexa populations were caged on lambda-cyhalothrin-treated cotton plants, after which survival and egg production (for those caged at adult stage) were assessed. In the laboratory, similar groups were subjected to dried residues and topical treatment with one of eight pyrethroids (alpha-cypermethrin, bifenthrin, deltamethrin, esfenvalerate, fenpropathrin, permethrin, zeta-cypermethrin, and lambda-cyhalothrin), the organophosphate methidathion, or water and wetting agent. After caging on treated cotton terminals, 66% of the R-population larvae survived to adulthood, compared with 2% of those from the S-population. At 12 d after caging at adult stage under the same conditions, 64% of the females from the R-population survived and laid eggs, compared with 100% mortality and no oviposition for the S-females. In trials involving dried insecticide residues, gain in survival based on the survival difference (percentage for R-population minus percentage for S-population) across all tested pyrethroids varied from 3 to 63% for larvae and from 3 to 70% for adults. In trials involving topical sprays of the tested pyrethroids, survival differences ranged from 36 to 96% for larvae and from 21 to 82% for adults. Fenpropathrin and bifenthrin were the least and most toxic, respectively. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. CHRISTIAN EGALITARIANISM:THE BOOK OF THE CITY OF LADIES VERSUS THE BIBLE

    Merve Aydogdu

    2012-02-01

    Full Text Available The Bible is the sacred text of Christianity and Judaism and it contains stories about the lives of the people in the past. Some of these stories are about the women. In them, the women are either represented in derogatory terms such as sinful- being the descendants of Eve or portrayed less important than the men. In both cases, the women are not given the position they deserve and the male-female inequality inherent in the society gains strength with the holy book. On the other hand, taking some verses of it as their mainstay, Christian egalitarians defend that both sexes are equal in the eyes of God. Similarly, 14th century French author Christine de Pizan purports that the women are as intelligent and powerful as the men. To this end, she provides us with many woman portraits. Her stories function as a reply to the ones in the Bible and try to refute the misrepresentation of the women in it. Hence, it would not be wrong to state that she was among the first defenders of equality between the sexes and that she was courageous enough to stand up to the holy book.

  8. Response of different populations of seven lady beetle species to lambda-cyhalothrin with record of resistance.

    Rodrigues, Agna R S; Spindola, Aline F; Torres, Jorge B; Siqueira, Herbert A A; Colares, Felipe

    2013-10-01

    Simultaneous use of biological and chemical controls is a valued and historic goal of integrated pest management, but has rarely been achieved. One explanation for this failure may be the inadequate documentation of field populations of natural enemies for insecticide tolerance or resistance because natural enemies surviving insecticide application do not create problems like resistant pest species. Therefore, this study investigated 31 populations of lady beetles (Coleoptera: Coccinellidae) regarding their susceptibility to lambda-cyhalothrin, a pyrethroid insecticide that is widely used in cotton and other crops to control lepidopteran and coleopteran pests that are not targeted as prey by lady beetles. The study focused on seven coccinellid species common in cotton fields Coleomegilla maculata De Geer, Cycloneda sanguinea (L.), Eriopis connexa Germar, Harmonia axyridis (Pallas), Hippodamia convergens Guérin-Méneville, Olla v-nigrum (Mulsant), and Brumoides foudrasi (Mulsant) and one lady beetle species [Curinus coeruleus Mulsant] from a non-cotton ecosystem for comparisons. Dose-mortality curves were estimated after topical treatment of adult lady beetles with lambda-cyhalothrin. Statistically significant variations in lady beetle susceptibility were observed between species and between populations of a given species. Seven and eighteen populations of lady beetles exhibited greater values of LD50 and LD90, respectively, than the highest recommended field rate of lambda-cyhalothrin (20g a.i./hectare≈0.2g a.i./L) for cotton fields in Brazil. Furthermore, based on LD50 values, 29 out of 30 tested populations of lady beetles exhibited ratios of relative tolerance varying from 2- to 215-fold compared to the toxicity of lambda-cyhalothrin to the boll weevil, Anthonomus grandis Boh. (Coleoptera: Curculionidae). Four populations of E. connexa were 10.5-37.7 times more tolerant than the most susceptible population and thus were considered to be resistant to lambda

  9. The twenty-five maiden ladies' tomb and predicaments of the feminist movement in Taiwan

    Lee, Anru; Tang, Wen-hui Anna

    2010-01-01

    The Twenty-five Maiden Ladies’ Tomb” is the collective burial site of the female workers who died in a ferry accident on their way to work in 1973. The fact that of the more than 70 passengers on board all 25 who died were unmarried young women, and the taboo in Taiwanese culture that shuns unmarried female ghosts, made the Tomb a fearsome place. Feminists in Gaoxiong (高雄) had for some years wanted the city government to change the tomb’s public image....

  10. "The Lady Is Not Returning!": Educational Precarity and a Social Haunting in the UK Coalfields

    Bright, N. Geoffrey

    2016-01-01

    Drawing on research in de-industrialised coal-mining communities in the north of England, this article focuses on how experiences of some young people might be approached through a notion of precarity linked to the idea of a "social haunting" of the coalfields. Concentrating on data gathered in the period after the 2010 change of UK…

  11. Report of the unannounced inspection at Our Lady of Lourdes Hospital, Drogheda, Co. Louth.

    Ryan, M A

    2017-06-01

    The Irish National Consent Policy (NCP)¹ proposes that the legal requirement for consent extends to all forms of interventions, investigations and treatment, carried out on or behalf of the Health Service Executive (HSE). This study employs a quantitative descriptive approach to investigate the practices for obtaining consent for an identified group of routine neonatal procedures in neonatal facilities throughout Ireland. The BAPM (British Association of Perinatal Medicine)² guidelines were identified as ‘gold standard’ for the purposes of this study. The results indicated a lack of consistency between participating units pertaining to the modes of consent utilised and notable variances from ‘gold standard’ guidelines. Unanimity was evident for 3 procedures only (administering BCG, 6-in-1, and donor breast milk to infant). Significant findings related to EEG with video recordings, MRI\\/CT and gastro intestinal imaging, screening of an infant with suspected substance abuse or retinopathy of prematurity screening (ROP), administration of Vitamin K, and the carrying out of a lumbar puncture.

  12. [The embroidery work of the lady at Saint-Anne Hospital].

    Thillaud, Pierre L; Postel, Jacques

    2014-01-01

    In July 1974, a 72 old woman had been a patient for forty years in Sainte-Anne Hospital, Ward C. As she had again a violent brawl with her neighbour patient, she revealed being a tremendous artist. She had been confined on account of dementia paralytica in the Mecca of malariotherapy, and passionately devoted herself to embroidery. Her fancy work was rather a matter for Jean Dubuffet's art through its perfect expression and deserved being known.

  13. Transcriptome analysis of the painted lady butterfly, Vanessa cardui during wing color pattern development.

    Connahs, Heidi; Rhen, Turk; Simmons, Rebecca B

    2016-03-31

    four species that have no known homologs in other metazoans. This study provides a comprehensive list of differentially expressed transcripts during wing development, revealing potential candidate genes that may be involved in regulating butterfly wing patterns. Some differentially expressed genes have no known homologs possibly representing genes unique to butterflies. Results from this study also indicate that development of nymphalid wing patterns may arise not only from melanin and ommochrome pigments but also the pteridine pigment pathway.

  14. THE TALE OF THE MIRACULOUS ICON OF OUR LADY OF KAZAN” IN THE LIGHT OF OLD RUSSIAN LITERARY TRADITION

    Vladimir M. Kirillin

    2017-03-01

    Full Text Available “The Tale of the Miraculous Image of Our Lady of Kazan” is related to other Old Russian tales with the motif of apparition or discovery of the icon of Our Lady. Reading this tale in comparison with the tales of Kolochskaya, Tikhvin, Okovetskaya, and Vydropusskaya icons, I will focus on the structure of its plot motifs that organize the tale’s narrative. The essay reveals a combination of traditional and novel features in the construction of the text and the specificity of the story. The latter was determined by some general trends in the development of Russian literature at the end of the 16 th century as well as by the social circumstances in the newly added Kazan State and by the official position of the Kazan Metropolitan Hermogenes, a presumed author of the tale. A comparative reading reveals typicality and conventionality as regards the plot, the structure, and the language of the tale about the Kazan icon, despite the presence of new motifs and elements of authorial self- reflection. The author of the tale rigorously followed official ideological and aesthetic line as well as existing literary standards and was guided by the mainstream clerical, political, and spiritual ideas that did not favor descriptive exaggerations inspired by imagination, religious exaltation, and mysticism. There is a stark contrast between the conventional tale by Anonymous-Hermogenes and legends about Kolochskaya, Okovetskay, and (to some extent Vydropusskaya icons of the Holy Virgin that represent narratives dramatically and stylistically close to the folk speech. Such reading gives grounds to certain conclusions about the peculiarities of the historical development of Russian literature in Moscow Rus’ of the second half of the 16 th century. The official line of its development was primarily aimed at the conservation and formalization of creative work.

  15. Collar of Lady's Wear in Qing Dynasty

    LI Xiao-jun

    2007-01-01

    The research is started with a query that whether the width of collar in Qing Dynasty Is too small. The paper bases on the statistics which come from the collection of the Costume Museum of Donghua University. compares the results with the natlonal standard specification, then analyzes the structure and shape of collars in Qing Dynasty, and tells the relationship between collar and the garment. Furthermore, the paper discusses the function of lady's collar in Qing Dynasty and gives a suggestion that collar being an Indicator to distinguish women's wear from children's wear.

  16. Madame Wu Chien-Shiung the first lady of physics research

    Chiang, Tsai-Chien

    2014-01-01

    Narrating the well-lived life of the "Chinese Madame Curie" - a recipient of the first Wolf Prize in Physics (1978), the first woman to receive an honorary doctorate from Princeton University, as well as the first female president of the American Physics Society - this book provides a comprehensive and honest account of the life of Dr. Chien-Shiung Wu, an outstanding and leading experimental physicist of the 20th century.

  17. Fair and Tender Ladies versus Jim Crow: The Politics of Co-Education

    Riley, Karen L.

    2010-01-01

    In the current vernacular, co-education means the education of the sexes together within an institutional setting. Once a phenomenon, today, women enjoy nearly equal status on campuses that were at one time bastions of "maleness." Moreover, the counter-culture revolution of the late 1960s and throughout the 1970s, ushered in a new…

  18. Fluid catalytic cracking: recent developments on the grand old lady of zeolite catalysis

    Vogt, E.T.C.|info:eu-repo/dai/nl/073717398; Weckhuysen, B.M.|info:eu-repo/dai/nl/285484397

    2015-01-01

    Fluid catalytic cracking (FCC) is one of the major conversion technologies in the oil refinery industry. FCC currently produces the majority of the world's gasoline, as well as an important fraction of propylene for the polymer industry. In this critical review, we give an overview of the latest

  19. Working ladies: Mennonite women in the enterprise of Spanish Lookout, Belize

    Roessingh, C.H.; Mol, L.

    2008-01-01

    This article addresses the role of women in the labour system of the Mennonite entrepreneurs in a community in Belize, Central America. The labour system of the Mennonite enterprises is mainly organised independently of the general Belizean labour system. Mennonite women have gained a pivotal

  20. Australia's nuclear reactor: how safe is the old lady of Lucas Heights?

    Darroch, R.

    1990-01-01

    Safety procedures at the Lucas Heights reactor are discussed based on concerns voiced by a group of senior engineers working at the site. An account is also given of the responses to this claims of the authorities, the courts as well as some of the safety considerations outlined in a recent review of HIFAR management, recently completed by a team of nuclear experts from the Atomic Energy of Canada. It is argued that sufficient doubts have been raised to warrant an independent inquiry on the safety and future of the aging reactor. ills

  1. First Guatemalan record of natural hybridisation between Neotropical species of the Lady's Slipper orchid (Orchidaceae, Cypripedioideae).

    Szlachetko, Dariusz L; Kolanowska, Marta; Muller, Fred; Vannini, Jay; Rojek, Joanna; Górniak, Marcin

    2017-01-01

    The first natural hybrid in the section Irapeana of the orchid genus Cypripedium is described and illustrated based on Guatemalan material. A molecular evaluation of the discovery is provided. Specimens with intermediate flowers between C. irapeanum and C. dickinsonianum within ITS and Xdh sequences have the signal sequence of both these species. The analysis of plastid sequences indicated that the maternal line is C. irapeanum . Information about the ecology, embryology and conservation status of the novelty is given, together with a distribution map of its parental species, C. irapeanum and C. dickinsonianum . A discussion of the hybridization between Cypripedium species is presented. The potential hybrid zones between the representatives of Cypripedium section Irapeana which were estimated based on the results of ecological niche modeling analysis are located in the Maya Highlands ( C. dickinsonianum and C. irapeanum ) and the eastern part of Southern Sierra Madre ( C. molle and C. irapeanum ). Moreover, all three Cypripedium species could inhabit Cordillera Neovolcánica according to the obtained models; however, it should be noticed that this region is well-distanced from the edges of the known geographical range of C. molle .

  2. Cultural stereotyping of the lady in 4Q184 and 4Q185

    Ananda Geyser-Fouché

    2016-10-01

    Full Text Available Wisdom and wickedness as a ‘Woman’ have always attracted much discussion, especially in the ways images of the female are employed in wisdom literature. This article focuses on two Qumran texts that fall into the category of wisdom literature, namely 4Q184 and 4Q185, and the metaphorical appropriation of the woman as a figure of wisdom or a figure of wickedness. By combining a number of traditions in certain forms, sages tried to establish an education for their learners on how to obtain wisdom with the ultimate purpose of creating harmony. The ultimate purpose of the wisdom teachings of the sages was to confirm the harmony in the universe, and these teachings were also conveyed to their learners. In their instructions, they often employed binary opposites such as ‘wise’ and ‘fool’ according to which someone was characterised, or rather stereotyped. The result of such binary stereotyping was that the ‘whore’ and the ‘holy one’ represented opposite poles, and became fixed images in Judaism. According to feminist exegetes, these images typify the concept of cultural stereotyping. This article aims to illustrate that two Qumran texts, 4Q184 and 4Q185, regarded as wisdom texts, employ the female stereotypes that were known in the wisdom literature of Judaism.

  3. Cultural stereotyping of the lady in 4Q184 and 4Q185

    Ananda Geyser-Fouché

    2016-05-01

    Full Text Available Wisdom and wickedness as a ‘Woman’ have always attracted much discussion, especially in the ways images of the female are employed in wisdom literature. This article focuses on two Qumran texts that fall into the category of wisdom literature, namely 4Q184 and 4Q185, and the metaphorical appropriation of the woman as a figure of wisdom or a figure of wickedness. By combining a number of traditions in certain forms, sages tried to establish an education for their learners on how to obtain wisdom with the ultimate purpose of creating harmony. The ultimate purpose of the wisdom teachings of the sages was to confirm the harmony in the universe, and these teachings were also conveyed to their learners. In their instructions, they often employed binary opposites such as ‘wise’ and ‘fool’ according to which someone was characterised, or rather stereotyped. The result of such binary stereotyping was that the ‘whore’ and the ‘holy one’ represented opposite poles, and became fixed images in Judaism. According to feminist exegetes, these images typify the concept of cultural stereotyping. This article aims to illustrate that two Qumran texts, 4Q184 and 4Q185, regarded as wisdom texts, employ the female stereotypes that were known in the wisdom literature of Judaism.

  4. Fluid catalytic cracking: recent developments on the grand old lady of zeolite catalysis

    2015-01-01

    Fluid catalytic cracking (FCC) is one of the major conversion technologies in the oil refinery industry. FCC currently produces the majority of the world's gasoline, as well as an important fraction of propylene for the polymer industry. In this critical review, we give an overview of the latest trends in this field of research. These trends include ways to make it possible to process either very heavy or very light crude oil fractions as well as to co-process biomass-based oxygenates with regular crude oil fractions, and convert these more complex feedstocks in an increasing amount of propylene and diesel-range fuels. After providing some general background of the FCC process, including a short history as well as details on the process, reactor design, chemical reactions involved and catalyst material, we will discuss several trends in FCC catalysis research by focusing on ways to improve the zeolite structure stability, propylene selectivity and the overall catalyst accessibility by (a) the addition of rare earth elements and phosphorus, (b) constructing hierarchical pores systems and (c) the introduction of new zeolite structures. In addition, we present an overview of the state-of-the-art micro-spectroscopy methods for characterizing FCC catalysts at the single particle level. These new characterization tools are able to explain the influence of the harsh FCC processing conditions (e.g. steam) and the presence of various metal poisons (e.g. V, Fe and Ni) in the crude oil feedstocks on the 3-D structure and accessibility of FCC catalyst materials. PMID:26382875

  5. Physiological Perturbation Reveals Modularity of Eyespot Development in the Painted Lady Butterfly, Vanessa cardui

    Rhen, Turk; Simmons, Rebecca B.

    2016-01-01

    Butterfly eyespots are complex morphological traits that can vary in size, shape and color composition even on the same wing surface. Homology among eyespots suggests they share a common developmental basis and function as an integrated unit in response to selection. Despite strong evidence of genetic integration, eyespots can also exhibit modularity or plasticity, indicating an underlying flexibility in pattern development. The extent to which particular eyespots or eyespot color elements exhibit modularity or integration is poorly understood, particularly following exposure to novel conditions. We used perturbation experiments to explore phenotypic correlations among different eyespots and their color elements on the ventral hindwing of V. cardui. Specifically, we identified which eyespots and eyespot features are most sensitive to perturbation by heat shock and injection of heparin—a cold shock mimic. For both treatments, the two central eyespots (3 + 4) were most affected by the experimental perturbations, whereas the outer eyespot border was more resistant to modification than the interior color elements. Overall, the individual color elements displayed a similar response to heat shock across all eyespots, but varied in their response to each other. Graphical modeling also revealed that although eyespots differ morphologically, regulation of eyespot size and colored elements appear to be largely integrated across the wing. Patterns of integration, however, were disrupted following heat shock, revealing that the strength of integration varies across the wing and is strongest between the two central eyespots. These findings support previous observations that document coupling between eyespots 3 + 4 in other nymphalid butterflies. PMID:27560365

  6. Law, pregnancy and sport: what are the repercussions when a pregnant lady plays?

    Werren, Julia

    2006-08-01

    This article reflects on the issue of pregnancy and sport that was brought to the fore in Gardner v National Netball League (2001) 182 ALR 408; [2001] FMCA 50 and Gardner v All Australia Netball Association Ltd (2003) 174 FLR 452. It suggests that these cases did not provide a definitive discussion of the tortious liability implications that initially led Netball Australia to introduce a ban on pregnant players. In an attempt to fill some of these gaps, other case law that deals with liability of sporting organisations and prenatal injury is discussed. The article primarily focuses on whether the unborn child when born alive will have an action against her or his mother as a result of injury occasioned while the mother was playing sport when pregnant. This examination is undertaken in light of recent Australian tort reform as well as changes in policy direction. The article summarises the legal position of the parties involved in sport--sporting organisations, medical practitioners, other participants and the pregnant mother--and argues that, with reference to the guidelines and case law, in only a very small number of cases would liability be found against the sporting organisation or pregnant mother as a result of injuries incurred prenatally.

  7. 76 FR 36138 - Certificate of Alternative Compliance for the Passenger Vessel CHICAGO'S LEADING LADY

    2011-06-21

    ... CONTACT: If you have questions on this notice, call LCDR Wm. Erik Pickering, District Nine, Prevention Branch, U.S. Coast Guard, telephone 216-902-6050. If you have questions on viewing or submitting material... as high as required for full compliance with Annex I of the Inland Rules Act. The Commandant, U.S...

  8. 76 FR 76812 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel LADY KAY; Invitation for...

    2011-12-08

    ... entered into this docket is available on the World Wide Web at http://www.regulations.gov . FOR FURTHER... KAY is: Intended Commercial Use of Vessel: ``sight seeing cruises, personal trips (cruises), sport...

  9. Epidemiology of Parkinson's Disease: The Rotterdam Study

    M.C. de Rijk (Maarten)

    1997-01-01

    textabstractAt present, Parkinson's disease (PO), after Alzheimer's disease, is generally considered to be the most frequent progressive neurodegenerative disease in the elderly. Due to the growing proportion of elderly in many populations, more and more persons will be affected by this disabling

  10. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  11. Astronaut Parazynski greets First Lady Hillary Clinton and Chelsea Clinton

    1999-01-01

    First Lady Hillary Rodham Clinton (right) and her daughter, Chelsea, are greeted by NASA Astronaut Scott E. Parazynski (left) upon their arrival at the Skid Strip at Cape Canaveral Air Station to view the launch of Space Shuttle mission STS-93. Liftoff is scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected to unlock the secrets of supernovae, quasars and black holes.

  12. First Lady Hillary Clinton is greeted by NASA Administrator Goldin

    1999-01-01

    First Lady Hillary Rodham Clinton and her daughter, Chelsea, are greeted by NASA Administrator Daniel S. Goldin upon their arrival at the Skid Strip at Cape Canaveral Air Station. Next to Gold are (from left) Deputy Director for Business Operations Jim Jennings and Mrs. Goldin. Mrs. Clinton and Chelsea are here to view the launch of Space Shuttle mission STS-93, scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five- day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X- ray telescope and is expected to unlock the secrets of supernovae, quasars and black holes.

  13. Dan Goldin chats with First Lady Hillary Clinton

    1999-01-01

    At the Apollo/Saturn V Center, NASA Administrator Daniel Goldin (right) chats with First Lady Hillary Rodham Clinton and others while waiting for the launch of STS-93. Much attention has been generated over STS-93 due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected to unlock the secrets of supernovae, quasars and black holes. Liftoff of Space Shuttle Columbia is scheduled for 12:36 a.m. EDT July 20.

  14. Lady with a Lamp.

    Bunker, John

    1983-01-01

    This history of the Statue of Liberty begins with its dedication on October 28, 1886. The statue's roots are then traced back to France in 1865 when the idea for such a monument was first conceived. The efforts of the sculptor, Frederick Auguste Bartholdi, and the construction of the statue are detailed as well as the difficulties Americans had in…

  15. Celebrating Lady Liberty's Centennial.

    Fowler, Charles B.

    1986-01-01

    The year 1986 marks the one hundredth birthday of the Statue of Liberty. The centennial provides an appropriate occasion for musical celebration. A list of musical compositions that teachers can use are provided. Difficulty level is indicated. (RM)

  16. Mapping Femininity as Self-reflection Strategy in Lady Mary Wortley Montagu’s Travel Letters

    Amelia Precup

    2017-01-01

    The present paper participates in the discussion about the differences between masculine and feminine modes of travel in terms of interests, perception, and representation, by exploring the Letters of the Right Honourable Lady M--y W--y M--e Written during Her Travels in Europe, Asia and Africa, by Lady Mary Wortley Montagu. As a traveller, Lady Mary engaged in the contemplation of cultural landscapes: she attempted to understand the social logic of the communities she met and to assess the c...

  17. Learning about Lady Liberty.

    Instructor, 1984

    1984-01-01

    The history and importance of the Statue of Liberty is developed into a teaching unit. Background information on how and why the statue was built is given. Sample activities for classroom use are included. (DF)

  18. The same love, the same faith, the same tears”: ecclesial initiatives about the cult of Our Lady of El Quinche to defend the Republic of the Sacred Heart, Ecuador (1883-1889

    Luis Esteban Vizuete Marcillo

    2017-07-01

    Full Text Available Within the conflict between church and state in the 19th century, the clergy and laymen tried to defend the establishment where the church had hegemony over the state and society. Between 1883 and 1889, Ecuador experienced some ecclesial initiatives to defend which stood for the idea of a Republic of the Sacred Heart. This article studies the case of Our Lady of El Quiche, a colonial massive cult, which was part of a process of re-appropriation and reinterpretation of its history. It also suffered a process of spreading and strengthening of its cult, linking with the image of the Republic, political conflicts and the power of the church. Between politics and religion, the discourses and practices of the clergy and the faithful show the intention of the church to shore up its own idea of a catholic Republic and an organized society. In this article, the use of manuscripts and printed sources give information to contrast multiple voices and multiple religious acts which performed a new local Mariology about El Quinche and a reaction to a context in which the religious hegemony and the participation of the clergy in politics were questioned; meanwhile the relations inside the church were recomposing.

  19. TDF and quantitative ultrasound bone quality in African patients on second line ART, ANRS 12169 2LADY sub-study.

    Kabore, Firmin Nongodo; Eymard-Duvernay, Sabrina; Zoungrana, Jacques; Badiou, Stéphanie; Bado, Guillaume; Héma, Arsène; Diouf, Assane; Delaporte, Eric; Koulla-Shiro, Sinata; Ciaffi, Laura; Cournil, Amandine

    2017-01-01

    Bone demineralization, which leads to osteoporosis and increased fracture risk, is a common metabolic disorder in HIV-infected individuals. In this study, we aimed to assess the change in bone quality using quantitative ultrasound (QUS) over 96 weeks of follow-up after initiation of second-line treatment, and to identify factors associated with change in bone quality. In a randomized trial (ANRS 12169), TDF and PI-naïve participants failing standard first-line treatment, from Burkina Faso, Cameroon, and Senegal were randomized to receive either TDF/FTC/LPVr, ABC/ddI/LPVr or TDF/FTC/DRVr. Their bone quality was assessed using calcaneal QUS at baseline and every 24 weeks until week 96. Stiffness index (SI) was used to measure bone quality. Out of 228 participants, 168 (74%) were women. At baseline, median age was 37 years (IQR: 33-46 years) and median T-CD4 count was 199 cells/μl (IQR: 113-319 cells/μl). The median duration of first-line antiretroviral treatment (ART) was 52 months (IQR: 36-72 months) and the median baseline SI was 101 (IQR: 87-116). In multivariable analysis, factors associated with baseline SI were sex (β = -10.8 [-18.1,-3.5] for women), age (β = -8.7 [-12.4,-5.1] per 10 years), body mass index (BMI) (β = +0.8 [0.1,1.5] per unit of BMI), and study site (β = +12.8 [6.5,19.1] for Cameroon). After 96 weeks of second-line therapy, a reduction of 7.1% in mean SI was observed, as compared with baseline. Factors associated with SI during the follow-up were similar to those found at baseline. Exposure to TDF was not associated with a greater loss of bone quality over time. Bone quality decreased after second-line ART initiation in African patients independently of TDF exposure. Factors associated with bone quality include age, sex, baseline BMI, study site, and duration of follow-up.

  20. Pictorial Real, Historical Intermedial. Digital Aesthetics and the Representation of History in Eric Rohmer’s The Lady and the Duke

    Tagliani Giacomo

    2016-09-01

    Full Text Available In The Lady and the Duke (2001, Eric Rohmer provides an unusual and “conservative” account of the French Revolution by recurring to classical and yet “revolutionary” means. The interpolation between painting and film produces a visual surface which pursues a paradoxical effect of immediacy and verisimilitude. At the same time though, it underscores the represented nature of the images in a complex dynamic of “reality effect” and critical meta-discourse. The aim of this paper is the analysis of the main discursive strategies deployed by the film to disclose an intermedial effectiveness in the light of its original digital aesthetics. Furthermore, it focuses on the problematic relationship between image and reality, deliberately addressed by Rohmer through the dichotomy simulation/illusion. Finally, drawing on the works of Louis Marin, it deals with the representation of history and the related ideology, in order to point out the film’s paradoxical nature, caught in an undecidability between past and present.

  1. The Construction of Epistolary Identity in a Gentry’s Communication Network of the Seventeenth Century: The Case of Jane Lady Cornwallis Bacon

    Gabriella Del Lungo Camiciotti

    2014-04-01

    Full Text Available There has recently been increasing scholarly interest in early modern correspondence and specifically also in women’s letter writing and reading. Starting from the late Middle Ages familiar responsibilities and domestic obligations led many women to write to their absent husbands or other relatives to exchange health news and inform them about family affairs. It is however in the early modern period that corresponding with relatives and friends became a widespread social practice ranging from official to familiar and personal correspondence; in this period female literacy increased thus allowing growing numbers of women to write and read their own letters. A growing number of female voices can thus be heard depicting early modern social life. The article focuses on a neglected aspect of women’s correspondence: it investigates not the sender’s epistolary identity, but that of the recipient through the analysis of the personal correspondence of Lady Cornwallis Bacon. The main theme of the article is to show how the epistolary identity of an early modern gentlewoman was constructed by her correspondents. It is assumed that modes of communicating information and achieving a specific goal through letters varied not only according to the relationship connecting the correspondents but also the purpose and content of letters. 

  2. Radionuclide study for the interstitial lung disease

    Kawakami, Kenji; Mori, Yutaka; Ujita, Masuo

    1991-01-01

    The contribution of pulmonary nuclear medicine was evaluated in 105 patients with interstitial pulmonary diseases (IPD). Ventilation study (V) with 81m Kr, distribution of compliance in thoraco-pulmonary system (C) by 81m Kr gas bolus inhalation method, perfusion study (Q) with 99m Tc-MAA, 67 Ga scintigraphy and an assessment of pulmonary epithelial permeability with 99m Tc-DTPA aerosol were performed as nuclear medicine procedures. Pulmonary function test (%DLco, vital capacity and functional residual capacity) and blood gas analysis were also examined. Abnormalities in V were larger than that in Q which was high V/Q mismatch finding, in the interstitial pneumonia. Correlation between V/Q mismatch and PaO 2 was, therefore, not significant. %DLco was decreased in cases with larger V/Q mismatches. 67 Ga accumulated in the early stage of interstitial pneumonia when CT or chest X-ray did not show any finding. %DLco was decreased in cases with strong accumulation of 67 Ga. 67 Ga might be useful to evaluate activity of the diseases. Pulmonary epithelial permeability was assessed by 99m Tc-DTPA inhalation study. This permeability accelerated in idiopathic interstitial fibrosis and sarcoidosis. Pulmonary epithelial permeability may be useful as an indicator for epithelial cell injury. (author)

  3. Radionuclide study for the interstitial lung disease

    Kawakami, Kenji; Mori, Yutaka; Ujita, Masuo (Jikei Univ., Tokyo (Japan). School of Medicine)

    1991-07-01

    The contribution of pulmonary nuclear medicine was evaluated in 105 patients with interstitial pulmonary diseases (IPD). Ventilation study (V) with {sup 81m}Kr, distribution of compliance in thoraco-pulmonary system (C) by {sup 81m}Kr gas bolus inhalation method, perfusion study (Q) with {sup 99m}Tc-MAA, {sup 67}Ga scintigraphy and an assessment of pulmonary epithelial permeability with {sup 99m}Tc-DTPA aerosol were performed as nuclear medicine procedures. Pulmonary function test (%DLco, vital capacity and functional residual capacity) and blood gas analysis were also examined. Abnormalities in V were larger than that in Q which was high V/Q mismatch finding, in the interstitial pneumonia. Correlation between V/Q mismatch and PaO{sub 2} was, therefore, not significant. %DLco was decreased in cases with larger V/Q mismatches. {sup 67}Ga accumulated in the early stage of interstitial pneumonia when CT or chest X-ray did not show any finding. %DLco was decreased in cases with strong accumulation of {sup 67}Ga. {sup 67}Ga might be useful to evaluate activity of the diseases. Pulmonary epithelial permeability was assessed by {sup 99m}Tc-DTPA inhalation study. This permeability accelerated in idiopathic interstitial fibrosis and sarcoidosis. Pulmonary epithelial permeability may be useful as an indicator for epithelial cell injury. (author).

  4. First lady meets AIDS patients in Thailand.

    1996-12-09

    First Lady Hillary Rodham Clinton, during her tour of Thailand: 1) joined a panel discussion at New Life Center, a missionary shelter and acquired immunodeficiency syndrome (AIDS) hospice that houses and educates 151 girls from remote hill tribes who were rescued from being, or from becoming, brothel prostitutes or "restaurant hostesses"; 2) inspected a U.S. supported program in Chiang Rai province that provides scholarships, vocational training, and jobs to 1200 girls as income alternatives to their sale; and 3) toured a school that extends the education of girls beyond the mandatory age of 12, the age at which many are sold to Bangkok brothel middlemen. There are 500,000-700,000 prostitutes in Thailand; many die of AIDS. Girls can be sold for $1000 and send money home later; instead of poverty, the family has a new home, a motorcycle, and status. Mrs. Clinton emphasized the lifetime benefit available to a family when a girl is educated.

  5. 'Our queen of hearts' - the glorification of Lady Diana Spencer: a critical appraisal of the glorification of celebrities and new pilgrimage

    Céline Grünhagen

    2010-01-01

    Full Text Available Religiosity and spirituality respectively have always been and will be subject to change. The emergence of the manifold forms of new religious and spiritual movements in the last century includes a variety of cult-like vener­ations of specific individuals, such as politicians (e.g. Mao, Lenin and modern idols (e.g. Elvis Presley, Princess Diana, Michael Jackson, who are glorified like saints. Devotees gather annually for memorials of their departed idols or travel­ long distances to visit the tomb, former home, etc. of a specific person to pay tribute to him or her. Due to the motivations of these devotees, the trouble they take, the practices and the tangible emotionality that are connected with this phenomenon, it can be considered a form of pilgrimage. This article presents some thoughts about the glorification of celebrities which leads to these considerable forms of cult and pilgrimage, using as an example the case of Lady Diana Frances Spencer (d. 1997.

  6. “Gay, Elderly, Self-Standing Lady From the Castle Rauhenstein”: Elements of Romantic Friendship in the Works of Pavlina Pajk

    Nataša Velikonja

    2014-06-01

    Full Text Available Text analyzes the work of novelist and poet Pavlina Pajk (1854–1901, who is considered to be “the first lady of Slovenian women’s novel”, but most of the time her opus was disregarded and misunderstood. Pavlina Pajk was ranked, among other things, among those “inappropriate, excessively emancipated women”, “adherents of George Sand”, as signified by feminists at the turn of the 19th to 20th century, who with their life and work raised more radical class, status, gender and sexual, in short, identity issues as it was established by the then dominant national canon. Among other things, Pavlina Pajk advocated sexual relativity and opposed gender and sexual conventions of her time. In many of her works we can find elements of romantic friendship, specific form of love between women, in American and European societies quite frequent until the early 20th century. Thus we can gain an insight into the pre-homosexual or pre-lesbian discourse of the 19th century literature in Slovenian language.

  7. Iron lady, reflexiones sobre la imagen y el liderazgo. Iron lady, reflections about image and leadership

    María Arnal Canudo

    2012-04-01

    Full Text Available A través de diversas teorías sobre el liderazgo así como la influencia del cine en el legado visual y biográfico de algunas personalidades relevantes, este artículo analiza el liderazgo de Margaret Thatcher mostrado en la película Iron Lady, sobrenombre con el que se la conoce. El largometraje presenta la figura de la que fuera primera ministra de Gran Bretaña a través de los recuerdos de su protagonista, los factores y circunstancias personales que influyeron en su estilo de gobernar y liderazgo, su personalidad y su faceta en el entorno familiar.Through some theories about leadership as well as the influence of the cinema in the visual and biographical legacy of some excellent personalities, this article analyzes the Margaret Thatcher’s leadership in the film Iron Lady, nickname with which she is known. The film shows the ex Prime Minister of Great Britain through hers personal memories, factors and circumstances that influenced in her style to govern and her leadership, its personality and its facet in the familiar surroundings.

  8. Extrapulmonary tuberculosis in lady reading hospital peshawar, NWFP, pakistan: survey of biopsy results

    Rehman, A.U.; Kamal, A.

    2008-01-01

    Tuberculosis is a disease of poor countries. In the recent years, there has been an increase in the occurrence of extra-pulmonary tuberculosis (EPTB) world over. As very little data is available regarding the situation of EPTB in NWFP, this study was conducted to asses its frequency in various organ systems of the body and to evaluate the role of demographic factors like sex and age in its causation. A total of 525 cases of EPTB diagnosed histopathologically in the Department of Pathology, Lady Reading Hospital Peshawar in the years 2002-2005 were included in the study. Age, sex and sites of biopsies were recorded. High female preponderance was noted with a M:F ratio of 1:2. Mean age was 35 years and 70% of the patients were in the age group 15-45 years. Lymph nodes were the most common site of EPTB, involved in 66.4% of the cases. EPTB has high rates in females in their reproductive age. Tuberculous lymphadenitis is the most common form of EPTB. High occurrence of EPTB in female population needs immediate attention of tuberculosis control programs. (author)

  9. Gender blending a queer performativita ve videoklipech Lady Gaga

    Sekyrová, Karolína

    2014-01-01

    This bachelor thesis examines how queer performativity and gender blending are shown in the music video clips of Lady Gaga. The thesis attemp to find and analyse through the means of the semiotic analysis and explain their meaning. The thesis is based on theoretical gender definition and on two constructivism concepts: Doing gender by West and Zimermann and gender performativity by Judith Butler. The thesis employs the queer concept as the reconstruction of sexual minorities but also as an an...

  10. THE UNICORN and the LADY under the view of the analysis of design and execution of the Middle Age

    Toker, Günseli

    2017-01-01

    The weaving of tapestry ( Goblen ; Gobelins) has been evolved with the evolvement of the culture since the Middle Ages. The emblematic and decorative designs and motifs woven at the early stages of tapestry , express different meaning than today. The woven tapestry which was a need at the beginning has turned into descriptive art over the years. The art of tapestry is one of the common craft works of the different cultures. Although the materials used could vary but the technique of tapest...

  11. Molecular Genetic Studies of Some Eye Diseases Affecting the ...

    First page Back Continue Last page Overview Graphics. Molecular Genetic Studies of Some Eye Diseases Affecting the Indian Population. Single gene disorders. Complex eye diseases. Genotype-phenotype correlation. Molecular diagnostics.

  12. Tarotkorttien historiaa pelikortteina : kohteena Lady Knight -kortti

    Pylkkö, Ina

    2015-01-01

    Opinnäytetyö käsittelee tarot-korttien historiaa pelikortteina ja Cary-Yale Visconti -tarotpakan Lady Knight -korttia. Opinnäytetyöhön kuuluu toiminnallinen osuus, jossa toteutettiin uusi versio Lady Knight -kortista yhdistämällä digitaalinen maalaus ja kultaus. Tarot-kortteja on tutkittu taidehistorian sekä viestinnän näkökulmasta vain vähän. Opinnäytetyö rajaa ulkopuolelle ennustukseen ja okkultismiin liittyvät teoriat ja keskittyy näin pelin historiaan. Työssä perehdytään ensin taideh...

  13. A Clinico-Pathological Study on Benign Breast Diseases

    Sangma, Mima B. Maychet; Panda, Kishori; Dasiah, Simon

    2013-01-01

    Background: To study the patterns of clinically benign breast disease in females and to co-relate them with the pathological findings. Methods: One hundred females who attended the Surgery Outpatients Department in Indira Gandhi Medical College and Research Institute, Pondicherry, with various forms of benign breast diseases during the period from October 2011 to September 2012, were studied. Early diagnoses by doing a triple assessment like a clinical examination, FNAC or a core needle biopsy and imaging methods like ultrasonography or mammography, were made within 72 hrs from the first consultation. The clinical diagnoses were compared with the cytological or histological findings wherever possible and their accuracies were evaluated. Results: Out of the 100 female patients who were studied, 87 patients who presented with breast lumps and fibroadenoma, accounted for 48% of the cases, which was the highest number of patients. Fibrocystic changes and breast abscesses came next with 18% and 12% cases respectively. We detected 3 cases of proliferative disease with atypia and one case with florid hyperplasia, which had high and low risk factors respectively, for developing invasive carcinoma. The oldest lady of the group who was clinically diagnosed to have benign disease, was detected to have invasive ductal carcinoma. They were treated in our hospital and were advised follow up. Conclusion: Benign breast diseases are common in female patients and fibroadenoma is the commonest of them all. Triple assessment provided a quick diagnosis and it alleviated unnecessary anxiety from the patients about breast cancer. The clinical diagnosis of a breast lump, as confirmed by cytology and histology, was accurate in 91.95 % of the cases. PMID:23634406

  14. Myynnin ja markkinoinnin parantaminen case Lady Line Tampere

    Savolainen, Johanna

    2016-01-01

    Tämän opinnäytetyön tavoitteena oli kehittää myynnin ja markkinoinnin keinoja franchising-yrityksessä. Toimeksiantaja työlle oli Lady Line Tampereen toimitusjohtaja Jukka Heinola. Heinola omistaa Tampereen Lady Linen toimipisteen sekä Nokian Lady Linen toimipisteen. Lady Line on suomalainen naisten hyvinvointi ketju, joka on aloittanut toimintansa vuonna 1987 Vaasassa. Markkinoinnissa liikkumavaraa on jonkin verran, mutta rajoitteitakin löytyy kiitettävästi. Lady Linen jokainen keskus noudatt...

  15. When gentlemen are first and ladies are last: effects of gender stereotypes on the order of romantic partners' names.

    Hegarty, Peter; Watson, Nila; Fletcher, Laura; McQueen, Grant

    2011-03-01

    A preference to name stereotypically masculine before stereotypically feminine individuals explains why men are typically named before women, as on the Internet, for example (Study 1). Heterosexual couples are named with men's names first more often when such couples are imagined to conform to gender stereotypes (Studies 2 and 3). First-named partners of imaginary same-sex couples are attributed more stereotypically masculine attributes (Study 4). Familiarity bounds these effects of stereotypes on name order. People name couples they know well with closer people first (Study 5), and consequently name familiar heterosexual couples with members of their own gender first (Study 6). These studies evidence a previously unknown effect of the semantics of gender stereotypes on sentence structure in the everyday use of English. ©2010 The British Psychological Society.

  16. A cross-sectional survey to study the relationship of periodontal disease with cardiovascular disease, respiratory disease, and diabetes mellitus.

    Oberoi, Sukhvinder Singh; Harish, Yashoda; Hiremath, Shivalingaswamy; Puranik, Manjunath

    2016-01-01

    Periodontal deterioration has been reported to be associated with systemic diseases such as cardiovascular disease (CVD), diabetes mellitus, respiratory disease, liver cirrhosis, bacterial pneumonia, nutritional deficiencies, and adverse pregnancy outcomes. The present study assessed the periodontal disease among patients with systemic conditions such as diabetes, CVD, and respiratory disease. The study population consisted of 220 patients each of CVD, respiratory disease, and diabetes mellitus, making a total of 660 patients in the systemic disease group. A control group of 340 subjects were also included in the study for comparison purpose. The periodontal status of the patients with these confirmed medical conditions was assessed using the community periodontal index of treatment needs (CPITNs) index. The prevalence of CPITN code 4 was found to be greater among the patients with respiratory disease whereas the mean number of sextants with score 4 was found to be greater among the patients with diabetes mellitus and CVD. The treatment need 0 was found to be more among the controls (1.18%) whereas the treatment need 1, 2, and 3 were more among the patients with respiratory disease (100%, 97.73%, and 54.8%), diabetes mellitus (100%, 100% and 46.4%), and CVD (100%, 97.73%, and 38.1%), in comparison to the controls (6.18%). From the findings of the present study, it can be concluded that diabetes mellitus, CVD, and respiratory disease are associated with a higher severity of periodontal disease.

  17. A cross-sectional survey to study the relationship of periodontal disease with cardiovascular disease, respiratory disease, and diabetes mellitus

    Sukhvinder Singh Oberoi

    2016-01-01

    Full Text Available Background: Periodontal deterioration has been reported to be associated with systemic diseases such as cardiovascular disease (CVD, diabetes mellitus, respiratory disease, liver cirrhosis, bacterial pneumonia, nutritional deficiencies, and adverse pregnancy outcomes. Aim: The present study assessed the periodontal disease among patients with systemic conditions such as diabetes, CVD, and respiratory disease. Materials and Methods: The study population consisted of 220 patients each of CVD, respiratory disease, and diabetes mellitus, making a total of 660 patients in the systemic disease group. A control group of 340 subjects were also included in the study for comparison purpose. The periodontal status of the patients with these confirmed medical conditions was assessed using the community periodontal index of treatment needs (CPITNs index. Results: The prevalence of CPITN code 4 was found to be greater among the patients with respiratory disease whereas the mean number of sextants with score 4 was found to be greater among the patients with diabetes mellitus and CVD. The treatment need 0 was found to be more among the controls (1.18% whereas the treatment need 1, 2, and 3 were more among the patients with respiratory disease (100%, 97.73%, and 54.8%, diabetes mellitus (100%, 100% and 46.4%, and CVD (100%, 97.73%, and 38.1%, in comparison to the controls (6.18%. Conclusion: From the findings of the present study, it can be concluded that diabetes mellitus, CVD, and respiratory disease are associated with a higher severity of periodontal disease.

  18. Who is the Little Old Lady of International Crimes? Nils Christie’s concept of the Ideal Victim Reinterpreted

    van Wijk, J.

    2013-01-01

    This article discusses to what extent Nils Christie's famous stereotype of the 'ideal victim' is applicable in a context of international crimes. It argues that the characteristics of the ideal victim of genocide, crimes against humanity and war crimes largely overlap with the ideal victim of

  19. Disability weights for the Global Burden of Disease 2013 study

    Salomon, Joshua A.; Haagsma, Juanita A.; Davis, Adrian; de Noordhout, Charline Maertens; Polinder, Suzanne; Havelaar, Arie H.|info:eu-repo/dai/nl/072306122; Cassini, Alessandro; Devleesschauwer, Brecht; Kretzschmar, Mirjam; Speybroeck, Niko; Murray, Christopher J L; Vos, Theo

    2015-01-01

    Background: The Global Burden of Disease (GBD) study assesses health losses from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set of disability weights to quantify health levels associated with non-fatal outcomes. The objective of this study was to estimate

  20. Disability weights for the Global Burden of Disease 2013 study

    Salomon, Joshua A; Haagsma, Juanita A; Davis, Adrian; de Noordhout, Charline Maertens; Polinder, Suzanne; Havelaar, Arie H; Cassini, Alessandro; Devleesschauwer, Brecht; Kretzschmar, MEE; Speybroeck, Niko; Murray, Christopher J L; Vos, Theo

    2015-01-01

    BACKGROUND: The Global Burden of Disease (GBD) study assesses health losses from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set of disability weights to quantify health levels associated with non-fatal outcomes. The objective of this study was to estimate

  1. Small is challenging; distal femur fracture management in an elderly lady with achondroplastic dwarfism.

    Murphy, Colin G; Chrea, Bopha; Molloy, Alan P; Nicholson, Paul

    2013-03-20

    Achondroplasia is an autosomal dominant dwarfing condition that represents the most common form of skeletal dysplasia. The disease is caused by a mutation in the gene encoding fibroblast growth factor receptor 3 (FGFR3) found at the p16.3 locus on chromosome 4 which results in severe inhibition of subchondral bone growth. Anatomic variations, including articular and periarticular deformities classically seen with this condition, amplify the complexity of fracture fixation. Blood volume loss, age-related bone fragility, component selection and positioning pose serious orthopaedic challenges. Concomitant cardiovascular, respiratory and neurological comorbidities pose additional high-risk perioperative considerations. Despite an estimated prevalence of 1:25 000 in the general population, there is little literature concerning the operative and postoperative treatment challenges faced by orthopaedic surgeons dealing with fracture management on a patient with this condition. We present a case of an intercondylar femoral fracture in an elderly achondroplastic lady successfully treated with percutaneous screw fixation.

  2. The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037

    Bruin Sjoerd C

    2010-10-01

    Full Text Available Abstract Background Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis. Methods/Design In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm. Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm. The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%. Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and power = 90% in favour of the patients with resection with primary anastomosis. Secondary endpoints for both arms are the number of days alive and outside the hospital, health related quality of life, health care utilisation and associated costs. Discussion The Ladies trial is a nationwide multicentre randomised trial on perforated diverticulitis that will provide evidence on the merits of laparoscopic lavage and drainage for purulent generalised peritonitis and on the optimal resectional strategy

  3. Judy Collins shares a laugh with First Lady Hillary Clinton

    1999-01-01

    Singer Judy Collins (left) shares a laugh with First Lady Hillary Rodham Clinton in the Apollo/Saturn V Facility. Both women are at KSC to view the launch of Space Shuttle mission STS-93 scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. Judy Collins has honored the commander with a song, 'Beyond the Sky,' which was commissioned by NASA through the NASA Art Program.

  4. Women who served Queen Mary and Queen Elizabeth : Ladies, Gentlewomen and Maids of the Privy Chamber, 1553-1603.

    Merton, Charlotte Isabelle.

    1992-01-01

    A brief introduction to the history of the Tudor Court and the subject in hand is enlarged upon in the second 'chapter ('The Court'). which describes the nature of the evidence available, the process of admission to the Privy Chamber, the hierarchy within it and the titles given to the various Privy Chamber posts, and official payment (wages, food and accommodation). Chamber reform and the status of the womens' own servants are also discussed. The third chapter ('Recruitment') turns to the cr...

  5. Aging and Alzheimer's Disease: Lessons from the Nun Study.

    Snowdon, David A.

    1997-01-01

    Describes a woman who maintained high cognitive test scores until her death at 101 years of age despite anatomical evidence of Alzheimer's disease. The woman was part of a larger "Nun Study" in which 678 sisters donated their brains to teach others about the etiology of aging and Alzheimer's disease. Findings are discussed. (RJM)

  6. H.E. Dr Danilo Türk President of the Republic of Slovenia (second from right) visiting the ATLAS detector with, from left to right, Ambassador A. Logar, Spokesperson F. Gianotti, Director-General R. Heuer, First Lady B. Miklič Türk and ATLAS Slovenian national contactperson M. Mikuz.

    Maximilien Brice

    2009-01-01

    H.E. Dr Danilo Türk President of the Republic of Slovenia (second from right) visiting the ATLAS detector with, from left to right, Ambassador A. Logar, Spokesperson F. Gianotti, Director-General R. Heuer, First Lady B. Miklič Türk and ATLAS Slovenian national contactperson M. Mikuz.

  7. Shifts in dynamic regime of an invasive lady beetle are linked to the invasion and insecticidal management of its prey

    Bahlai, C.A.; Werf, van der W.; O'Neal, M.; Hemerik, L.; Landis, D.A.

    2015-01-01

    The spread and impact of invasive species may vary over time in relation to changes in the species itself, the biological community of which it is part, or external controls on the system. Here we investigate whether there have been changes in dynamic regimes over the last 20 years of two invasive

  8. Aspekte van die outeursfunksie in Antjie Krog se Lady Anne (1989)

    M. Crous

    2002-01-01

    Aspects of the author function in Antjie Krog’s Lady Anne (1989) The purpose of this essay is to investigate the Foucauldian notion of the so-called “author function” in Antjie Krog’s seventh volume of poetry, viz. Lady Anne (1989). It is an attempt to show how the notion of the death of the author (Barthes) links up with this theorisation of Foucault. Furthermore, it is also an attempt to indicate the characteristic features of the so-called “author function” in the late eighties in Afr...

  9. Learned modesty and the first lady's comet: a commentary on Caroline Herschel (1787) 'An account of a new comet'.

    Winterburn, Emily

    2015-04-13

    Long before women were allowed to become Fellows of the Royal Society, or obtain university degrees, one woman managed to get her voice heard, her discovery verified and her achievement celebrated. That woman was Caroline Herschel, who, as this paper will discuss, managed to find ways to fit comet discoveries into her domestic life, and present them in ways that were socially acceptable. Caroline lived in a time when strict rules dictated how women (and men) should behave and present themselves and their work. Caroline understood these rules, and used them carefully as she announced each discovery, starting with this comet which she found in 1786. Caroline discovered her comets at a time when astronomers were mainly concerned with position, identifying where things were and how they were moving. Since her discoveries, research has moved on, as astronomers, using techniques from other fields, and most recently sending experiments into space, have learned more about what comets are and what they can tell us about our solar system. Caroline's paper marks one small, early step in this much bigger journey to understand comets. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

  10. The Prevalence of Fabry Disease in Patients with Chronic Kidney Disease in Turkey: The TURKFAB Study

    Kultigin Turkmen

    2016-12-01

    Full Text Available Background/Aims: Fabry disease is a treatable cause of chronic kidney disease (CKD characterized by a genetic deficiency of α-galactosidase A. European Renal Best Practice (ERBP recommends screening for Fabry disease in CKD patients. However, this is based on expert opinion and there are no reports of the prevalence of Fabry disease in stage 1-5 CKD. Hence, we investigated the prevalence of Fabry disease in CKD patients not receiving renal replacement therapy. Methods: This prospective study assessed α-galactosidase activity in dried blood spots in 313 stage 1-5 CKD patients, 167 males, between ages of 18-70 years whose etiology of CKD was unknown and were not receiving renal replacement therapy. The diagnosis was confirmed by GLA gene mutation analysis. Results: Three (all males of 313 CKD patients (0.95% were diagnosed of Fabry disease, for a prevalence in males of 1.80%. Family screening identified 8 aditional Fabry patients with CKD. Of a total of 11 Fabry patients, 7 were male and started enzyme replacement therapy and 4 were female. The most frequent manifestations in male patients were fatigue (100%, tinnitus, vertigo, acroparesthesia, hypohidrosis, cornea verticillata and angiokeratoma (all 85%, heat intolerance (71%, and abdominal pain (57%. The most frequent manifestations in female patients were fatigue and cornea verticillata (50%, and tinnitus, vertigo and angiokeratoma (25%. Three patients had severe episodic abdominal pain attacks and proteinuria, and were misdiagnosed as familial Mediterranean fever. Conclusions: The prevalence of Fabry disease in selected CKD patients is in the range found among renal replacement therapy patients, but the disease is diagnosed at an earlier, treatable stage. These data support the ERBP recommendation to screen for Fabry disease in patients with CKD of unknown origin.

  11. A cultural diversity seen in Croatian family medicine: a lady from Janjevo.

    Pavlov, Renata

    2014-12-01

    The role of cultural diversities in doctor's everyday work is going more and more important in globalised world, therefore it draws lots of attention in literature. Cultural differences that exist between people, such as language, dress and traditions, are usually distinguished from the term cultural diversity which is mainly understood as having different cultures respect each other's differences. The great effort is made to educate culturally competent practitioners, nurses or doctors. The presented case of lady from Janjevo was a good role model for work with all patients with culturally different background coming to family practice. This lady example could also help to other colleagues to learn from experience on systematic way.

  12. Retrospctive studies of small ruminant diseases diagnosed at the ...

    Retrospctive studies of small ruminant diseases diagnosed at the Veterinary Teaching Hospital, University of Agriculture, Makurdi, Nigeria. J.W. Jatfa, A.Y. Adenkola, I Victor, A Kisani, S.S. Adamu, P.A. Onyeyili ...

  13. Phytochemical analysis, antioxidant, antistress, and nootropic activities of aqueous and methanolic seed extracts of ladies finger (Abelmoschus esculentus L.) in mice.

    Doreddula, Sathish Kumar; Bonam, Srinivasa Reddy; Gaddam, Durga Prasad; Desu, Brahma Srinivasa Rao; Ramarao, Nadendla; Pandy, Vijayapandi

    2014-01-01

    Abelmoschus esculentus L. (ladies finger, okra) is a well-known tropical vegetable, widely planted from Africa to Asia and from South Europe to America. In the present study, we investigated the in vitro antioxidant capacity and in vivo protective effect of the aqueous and methanolic seed extracts of Abelmoschus esculentus against scopolamine-induced cognitive impairment using passive avoidance task and acute restraining stress-induced behavioural and biochemical changes using elevated plus maze (EPM) and forced swimming test (FST) in mice. Our results demonstrated that the pretreatment of mice with aqueous and methanolic seed extracts of Abelmoschus esculentus (200 mg/kg, p.o.) for seven days significantly (P nootropic activities which promisingly support the medicinal values of ladies finger as a vegetable.

  14. 27 February 2012 - First Lady of Mexico, M. Zavala Gómez del Campo, welcomed by Adviser J. Salicio Diez withe ALICE Management and Mexican Users at LHC Point 2 and signing the guest book with CERN Director-General R. Heuer.

    Maximilien Brice

    2012-01-01

    27 February 2012 - First Lady of Mexico, M. Zavala Gómez del Campo, welcomed by Adviser J. Salicio Diez withe ALICE Management and Mexican Users at LHC Point 2 and signing the guest book with CERN Director-General R. Heuer.

  15. « The glittering game » : le jeu des choses dans A Lost Lady et My Mortal Enemy de Willa Cather

    Manresa, Céline

    2014-01-01

    Dans A Lost Lady et My Mortal Enemy, Willa Cather confère aux choses un rôle étonnamment actif au cœur de l’intrigue et un relief inédit au sein de l’écriture. Loin de demeurer tapies dans l’ombre ou figées dans l’arrière-plan des décors, les choses investissent pleinement le devant de la scène diégétique et narrative. Du costume aux détails de la décoration, les choses gouvernent les jeux de modelage réciproque entre l’habitant et l’habitat, visant à transformer l’intérieur des maisons en un...

  16. The oral-systemic disease connection: a retrospective study.

    Joseph, Bobby K; Kullman, Leif; Sharma, Prem N

    2016-11-01

    The study aimed at determining the association between oral disease and systemic health based on panoramic radiographs and general health of patients treated at Kuwait University Dental Center. The objective was to determine whether individuals exhibiting good oral health have lower propensity to systemic diseases. A total of 1000 adult patients treated at Kuwait University Dental Center were randomly selected from the patient's records. The general health of patients was assessed from the medical history of each patient recorded during their visit to the clinic. The number of reported diseases and serious symptoms were used to develop a medical index. The oral health of these patients was assessed from panoramic radiographs to create an oral index by evaluating such parameters as caries, periodontitis, periapical lesions, pericoronitis, and tooth loss. In a total of 887 patients, 43.8 % had an oral index between 3 and 8, of which significantly higher (62.1 %) patients were with medical conditions compared to those without (33.2 %; p relationship when the diagnosis of oral disease was based primarily on radiographic findings. Future research needs to include prospective clinical and interventional studies. The significance of the oral-systemic disease connection highlights the importance of preventing and treating oral disease which have profound medical implications on general health.

  17. First Ladies' Symposium on Early Childhood in Egypt (Cairo, Egypt, May 21, 2001).

    O'Gara, Chloe

    This document is comprised of the papers presented at the First Ladies' Symposium on Early Childhood in Egypt in May 2001. Participating in the symposium were representatives from the World Bank, the Amsterdam Institute for International Development, the Children's Project, and the Academy for Educational Development. The symposium opened with an…

  18. Do Old Ladies Make World History?: Student Perceptions of Elder Female Agency

    Woodbum, Stephen M.

    2006-01-01

    In this article, the author shares the views of his undergraduate students regarding elder female agency and their answers to the question: "Do old ladies make world history?" Because his undergraduate students mostly view the past in terms of the Great Man theory of history, which holds that those who make history are necessarily great,…

  19. First Lady Hillary Clinton returns to KSC for second launch attempt

    1999-01-01

    Seated in the Banana Creek viewing site, First Lady Hillary Rodham Clinton appears attentive to the conversation of a fellow spectator. Mrs. Clinton and others are gathered to watch the second launch attempt of STS-93. Moments before the first scheduled launch, July 20, STS-93 was scrubbed at the T-7 second mark in the countdown due to an indication of a high concentration of hydrogen in an aft engine compartment. The reading proved to be a false alarm. The launch was rescheduled for July 22 at 12:28 a.m. Much attention has been generated over STS-93 due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe.

  20. Mapping Femininity as Self-reflection Strategy in Lady Mary Wortley Montagu’s Travel Letters

    Amelia Precup

    2017-07-01

    Full Text Available The present paper participates in the discussion about the differences between masculine and feminine modes of travel in terms of interests, perception, and representation, by exploring the Letters of the Right Honourable Lady M--y W--y M--e Written during Her Travels in Europe, Asia and Africa, by Lady Mary Wortley Montagu. As a traveller, Lady Mary engaged in the contemplation of cultural landscapes: she attempted to understand the social logic of the communities she met and to assess the cultural distance between the English society and the local customs of the countries she visited. Within this large social and cultural framework, the focus of her keen spirit of observation is represented, in many of her letters, by gender dynamics and the status of women, thus allowing a feminine configuration of the map of continental Europe and the Ottoman Empire and a comparative understanding of femininity and expected feminine behaviour. Therefore, the contention of this paper is that, in Lady Mary’s letters, the female-traveller’s gaze ends in meditation and self-contemplation, and functions as a means of comparing and reassessing female identity.

  1. First Lady Hillary Clinton gets ready to speak to group at VIP viewing site

    1999-01-01

    In the VIP Lounge, Apollo/Saturn V Center, First Lady Hillary Rodham Clinton gets ready to speak to the group gathered there before the launch of STS-93. At right is NASA Administrator Daniel Goldin. Liftoff of Space Shuttle Columbia is scheduled for 12:36 a.m. EDT July 20. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X- ray telescope and is expected to unlock the secrets of supernovae, quasars and black holes.

  2. First Lady Hillary Clinton waits for launch at VIP viewing site

    1999-01-01

    Among those gathered at the VIP viewing site for the launch of STS-93 are First Lady Hillary Rodham Clinton (center) and Donna Shalala, secretary , Department of Health and Human Services (far right). Also present is Chelsea Clinton. Much attention has been generated over the launch due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected to unlock the secrets of supernovae, quasars and black holes. Liftoff of Space Shuttle Columbia is scheduled for 12:36 a.m. EDT July 20.

  3. Lima bean – lady beetle interactions: hooked trichomes affect survival of Stethorus punctillum larvae

    We tested the hypothesis that Lima bean Phaseolus lunatus L. (Henderson cultivar) trichome density affects the survival of the acariphagous lady beetle Stethorus punctillum Weise. When isolated throughout larval development, 10% or less of S. punctillum larvae reared on two-spotted spider mite Tetr...

  4. Atlantic mackerel and Horse mackerel egg survey 2016: Dutch participation on board FV Atlantic Lady: May

    Damme, van C.J.G.

    2016-01-01

    From 10 till 25 May 2016 IMARES carried out a mackerel and horse mackerel egg survey on board the FV Atlantic Lady. This survey was part of the international mackerel and horse mackerel egg survey coordinated by ICES. The Redersvereniging voor de Zeevisserij (RVZ) asked IMARES to carry out this

  5. Sexy ladies sexing ladies: women as consumers in strip clubs.

    Wosick-Correa, Kassia R; Joseph, Lauren J

    2008-01-01

    Recent shifts in the consumer base of the sex industry have involved greater female attendance in strip clubs. This article examines how strip clubs and dancers incorporate female patrons into a sexualized space traditionally designed for men by identifying three interactional processes: passing over, sidestaging, and tailoring. We suggest dancers pass over women because they perceive female patron behavior to include resistance to "buying the game" and spending patterns that diverge from male customers. Drawing on Goffman's dramaturgical analysis, we suggest the dynamic relationship between dancer and female patron involves what we term sidestaging, which refers to both dancers' disclosure and how the club's spatial organization inhibits the construction of women as customers through sharing gendered spaces, such as the bathroom. We argue that when a dancer tailors her lap dance for a female patron, she succeeds in acknowledging the female customer's sexual subjectivity and potential same-sex desires by providing an individualized avenue for exploring an erotic experience. Finally, we discuss data implications for understanding how same-sex desire and sexual identity operate in an environment that eroticizes the female form, and how the strip club becomes a potential space for engaging in same-sex eroticism that includes elements of play.

  6. Effect of Chemical Treatment on Physical, Mechanical and Thermal Properties of Ladies Finger Natural Fiber

    S. I. Hossain

    2013-01-01

    Full Text Available In present research, natural fiber obtained from ladies finger plant was chemically treated separately using alkali (2% NaOH, chromium sulfate (4% , and chromium sulfate and sodium bicarbonate (4% . Both raw and chemically treated fibers were subsequently characterized using mechanical (tensile, structural (Fourier transform infrared spectroscopy and scanning electron microscopy, and thermal (thermogravimetric analysis. Fourier analysis showed the presence of (−OH group in the ladies plant fiber. Scanning electron micrographs revealed rougher surface in case of alkali treated fiber, while thin coating layer was formed on the fiber surface during other two treatments. Tensile test on ladies finger single fiber was carried out by varying span length. The tensile strength and Young's modulus values were found to be increased after chemical treatment. For both raw and chemically treated fibers, Young's modulus increased and tensile strength decreased with increase in span length. Thermogravimetric analysis indicated the same level of thermal stability for both raw and treated ladies finger fibers.

  7. Factitious prey and artificial diets for predatory lady beetles: current situation, obstacles, and approaches for improvement

    Predatory lady beetles (Coleoptera: Coccinellidae) are important natural enemies of many pests in crop ecosystems throughout the world. Although several species are currently mass-reared and sold by biocontrol companies, there is an urgent need to reduce rearing costs. Cost effective mass rearing of...

  8. Drosophila tools and assays for the study of human diseases

    Berrak Ugur

    2016-03-01

    Full Text Available Many of the internal organ systems of Drosophila melanogaster are functionally analogous to those in vertebrates, including humans. Although humans and flies differ greatly in terms of their gross morphological and cellular features, many of the molecular mechanisms that govern development and drive cellular and physiological processes are conserved between both organisms. The morphological differences are deceiving and have led researchers to undervalue the study of invertebrate organs in unraveling pathogenic mechanisms of diseases. In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. We discuss assays that have been developed in flies to study the function of specific genes in the central nervous system, heart, liver and kidney, and provide examples of the use of these assays to address questions related to human diseases. These assays provide us with simple yet powerful tools to study the pathogenic mechanisms associated with human disease-causing genes.

  9. Inflammation and peripheral venous disease. The San Diego Population Study.

    Cushman, M; Callas, P W; Allison, M A; Criqui, M H

    2014-09-02

    The inflammatory response to healing in venous thrombosis might cause vein damage and post-thrombotic syndrome. Inflammation may also be involved in venous insufficiency apart from deep-vein thrombosis. We studied the association of inflammation markers with venous insufficiency in a general population sample. We characterised 2,404 men and women in a general population cohort for peripheral venous disease and its severity using physical exam, symptom assessment, and venous ultrasound. Inflammation markers, C-reactive protein (CRP), fibrinogen, interleukin 1-beta (IL-1-beta), IL-8, IL-10, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, monocyte chemoattractant-1 (MCP-1) and vascular endothelial cell growth factor (VEGF) were compared in 352 case participants with peripheral venous disease and 352 controls with no venous abnormalities frequency matched to cases by age, sex and race. Associations were also evaluated including a subset of 108 cases of severe venous disease, as previously defined. Odds ratios (95% CI), for peripheral venous disease for biomarkers in the top quartile (adjusting for age, race, sex, body mass index and history of venous thrombosis) were 1.8 (1.1-3.0), 1.6 (1.0-2.5) and 1.5 (0.9-2.3) for CRP, fibrinogen and IL-10, respectively. Associations were larger considering cases of severe venous disease, with odds ratios for these three analytes of 2.6 (1.2-5.9), 3.1 (1.3-7.3) and 2.2 (1.1-4.4), and for IL-8: 2.4 (1.1-5.2). There was no association of IL-1-beta, ICAM-1, VCAM-1, E-selectin, MCP-1 or VEGF with overall cases or severe venous disease. In conclusion, a subset of inflammation markers were associated with increased risk of peripheral venous disease, suggesting potential therapeutic targets for treatment.

  10. A statistical study of the maxillofacial diseases by radiograms

    Chung, Yoo Tai; Lee, Sang Chull [College of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    1974-11-15

    This report based on 300 cases of serious diseases in maxillofacial region by radiograms seen at the department of dental radiodontics, infirmary school of dentistry, Kyung Hee University from October 1971 to August 1974. The maxillofacial diseases were analysed upon the following items, such as 1) the frequency of dominant diseases, 2) sex-ratio of male to female, 3) predominant region of diseases, 4) comparison with the age, 5) the incidence of diseases in relative to the individual teeth. The results were obtained as follows. 1) Among the total of 300 cases of the patients, the frequency of dominant diseases of patients were fractures of facial bone (44.3 {+-} 2.87%), inflammatory diseases (22.7 {+-} 2.39%), cysts (11.1 {+-} 1.62%), tumors(10.7 {+-} 1.77%), maxillary sinusitis (7.9 {+-} 1.56%), temporomandibular joint disorders(3.3 {+-} 1.05%) in the order. 2) The sex ratio of male to female in occurrence of jaw fractures were 7.3 : 1, temporomandibular joint disorders were 2.1 : 1, inflammatory diseases were 1.8:1, maxillary sinusitis were 1.7 : 1, but tumors were 1: 1, while cysts were 1:1 .2 in sex difference.3) The predominant region of mandibular fractures were symphysis (17.3 {+-} 3.27%), canine region (15.0 {+-} 3.09%), and angle region(14.3 {+-} 3.04%) in the order. Inflammatory diseases were occurred frequently in mandible and it's left side were a little dominant. Odontogenic cysts were observed frequently in maxilla, but regardless of right and left. Carcinomas were involved most frequently in maxilla, while sarcomas and ameloblastomas in mandible. Frequency of the maxillary sinusitis w ere dominant in right side and molar area, also temporomandibular joint disorders were dominant in right side. 4) To study comparing with the age, jaw fractures showed the highest ratio at the 2nd decade (32.3 {+-} 4.06%), and 3rd decade (27.8 {+-} 3.89%), 4th decade (19.6 {+-} 3.44%), 6th decade (9.0 {+-} 2.47%), 5th decade(6.0 {+-} 2.06%), lst decade(5.3 {+-} 1

  11. Neuroimaging Studies Illustrate the Commonalities Between Ageing and Brain Diseases.

    Cole, James H

    2018-07-01

    The lack of specificity in neuroimaging studies of neurological and psychiatric diseases suggests that these different diseases have more in common than is generally considered. Potentially, features that are secondary effects of different pathological processes may share common neurobiological underpinnings. Intriguingly, many of these mechanisms are also observed in studies of normal (i.e., non-pathological) brain ageing. Different brain diseases may be causing premature or accelerated ageing to the brain, an idea that is supported by a line of "brain ageing" research that combines neuroimaging data with machine learning analysis. In reviewing this field, I conclude that such observations could have important implications, suggesting that we should shift experimental paradigm: away from characterizing the average case-control brain differences resulting from a disease toward methods that place individuals in their age-appropriate context. This will also lead naturally to clinical applications, whereby neuroimaging can contribute to a personalized-medicine approach to improve brain health. © 2018 WILEY Periodicals, Inc.

  12. The association between periodontal disease and chronic obstructive pulmonary disease: a case control study.

    Öztekin, Görkem; Baser, Ulku; Kucukcoskun, Meric; Tanrikulu-Kucuk, Sevda; Ademoglu, Evin; Isik, Gulden; Ozkan, Gulcihan; Yalcin, Funda; Kiyan, Esen

    2014-08-01

    Although there are studies evaluating the effects of periodontal health on chronic obstructive pulmonary disease (COPD), the effects of COPD - a systemic disease, on periodontal tissue is unknown. The aim of this study is to evaluate the effects of COPD on periodontal tissues by comparing COPD patients and controls. Fifty-two COPD patients and 38 non-COPD controls were included in this case-control study. Number of teeth, plaque index (PI), gingival index (GI), bleeding on probing, clinical attachment level and probing depth were included in the periodontal examination. In addition to clinical evaluations, gingival crevicular fluid (GCF) levels of high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-lb) and prostaglandin-E2 (PGE2), and serum hs-CRP levels were measured in COPD patients and the controls. The number of teeth was significantly lower while PI and GI were significantly higher in COPD patients when compared to the controls. As well as serum hs-CRP levels, the GCF levels of hs-CRP, IL-1b and PGE2 were significantly higher in COPD patients than the controls. Our results demonstrated that COPD may be associated with periodontal disease as manifested by lower number of teeth and higher levels of inflammatory mediators especially CRP in GCF. This finding may be a reflection of systemic effects of COPD on periodontal tissues. Poor oral health behavior of COPD patients have to be considered in larger size group studies in the future.

  13. Circulatory disease mortality in the Massachusetts tuberculosis fluoroscopy cohort study

    Little, Mark P.; Zablotska, Lydia B.; Brenner, Alina V.; Lipshultz, Steven E.

    2016-01-01

    High-dose ionizing radiation is associated with circulatory disease. Risks from lower-dose fractionated exposures, such as from diagnostic radiation procedures, remain unclear. In this study we aimed to ascertain the relationship between fractionated low-to-medium dose radiation exposure and circulatory disease mortality in a cohort of 13,568 tuberculosis patients in Massachusetts, some with fluoroscopy screenings, between 1916 and 1961 and follow-up until the end of 2002. Analysis of mortality was in relation to cumulative thyroid (cerebrovascular) or lung (all other circulatory disease) radiation dose via Poisson regression. Over the full dose range, there was no overall radiation-related excess risk of death from circulatory disease (n = 3221; excess relative risk/Gy −0.023; 95 % CI −0.067, 0.028; p = 0.3574). Risk was somewhat elevated in hypertensive heart disease (n = 89; excess relative risk/Gy 0.357; 95 % CI −0.043, 1.030, p = 0.0907) and slightly decreased in ischemic heart disease (n = 1950; excess relative risk/Gy −0.077; 95 % CI −0.130, −0.012; p = 0.0211). However, under 0.5 Gy, there was a borderline significant increasing trend for all circulatory disease (excess relative risk/Gy 0.345; 95 % CI −0.032, 0.764; p = 0.0743) and for ischemic heart disease (excess relative risk/Gy 0.465; 95 % CI, −0.032, 1.034, p = 0.0682). Pneumolobectomy increased radiation–associated risk (excess relative risk/Gy 0.252; 95 % CI 0.024, 0.579). Fractionation of dose did not modify excess risk. In summary, we found no evidence of radiation-associated excess circulatory death risk overall, but there are indications of excess circulatory death risk at lower doses (<0.5 Gy). Although consistent with other radiation-exposed groups, the indications of higher risk at lower doses are unusual and should be confirmed against other data.

  14. The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review

    Di Piazza, Ambra; Costanzo, Massimo; Scopelliti, Laura; Salvaggi, Francesco; Cupido, Francesco; Salerno, Sergio; Lo Casto, Antonio; Midiri, Massimo; Lo Re, Giuseppe; Lagalla, Roberto

    2017-01-01

    Autoimmune connective tissue diseases are a heterogeneous group of pathologies that affect about 10% of world population with chronic evolution in 20%–80%. Inflammation in autoimmune diseases may lead to serious damage to other organs including the gastrointestinal tract. Gastrointestinal tract involvement in these patients may also due to both a direct action of antibodies against organs and pharmacological therapies. Dysphagia is one of the most important symptom, and it is caused by failure of the swallowing function and may lead to aspiration pneumonia, malnutrition, dehydration, weight loss, and airway obstruction. The videofluorographic swallowing study is a key diagnostic tool in the detection of swallowing disorders, allowing to make an early diagnosis and to reduce the risk of gastrointestinal and pulmonary complications. This technique helps to identify both functional and structural anomalies of the anatomic chain involved in swallowing function. The aim of this review is to systematically analyze the basis of the pathological involvement of the swallowing function for each rheumatological disease and to show the main features of the videofluorographic study that may be encountered in these patients. PMID:28706536

  15. Endothelial dysfunction, vascular disease and stroke: the ARTICO study.

    Roquer, J; Segura, T; Serena, J; Castillo, J

    2009-01-01

    Endothelial dysfunction is a fundamental step in the atherosclerotic disease process. Its presence is a risk factor for the development of clinical events, and may represent a marker of atherothrombotic burden. Also, endothelial dysfunction contributes to enhanced plaque vulnerability, may trigger plaque rupture, and favors thrombus formation. The assessment of endothelial vasomotion is a useful marker of atherosclerotic vascular disease. There are different methods to assess endothelial function: endothelium-dependent vasodilatation brachial flow-mediated dilation, cerebrovascular reactivity to L-arginine, and the determination of some biomarkers such as microalbuminuria, platelet function, and C-reactive protein. Endothelial dysfunction has been observed in stroke patients and has been related to stroke physiopathology, stroke subtypes, clinical severity and outcome. Resting ankle-brachial index (ABI) is also considered an indicator of generalized atherosclerosis, and a low ABI is associated with an increase in stroke incidence in the elderly. Despite all these data, there are no studies analyzing the predictive value of ABI for new cardiovascular events in patients after suffering an acute ischemic stroke. ARTICO is an ongoing prospective, observational, multicenter study being performed in 50 Spanish hospitals. The aim of the ARTICO study is to evaluate the prognostic value of a pathological ABI (ARTICO study will increase the knowledge of patient outcome after ischemic stroke and may help to improve our ability to detect patients at high risk of stroke recurrence or major cardiovascular events. (c) 2009 S. Karger AG, Basel.

  16. A Case-Control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD

    Francisco de Assis Aquino Gondim

    2015-02-01

    Full Text Available Neurological diseases are common in inflammatory bowel disease (IBD patients, but their exact prevalence is unknown. Method We prospectively evaluated the presence of neurological disorders in 121 patients with IBD [51 with Crohn's disease (CD and 70 with ulcerative colitis (UC] and 50 controls (gastritis and dyspepsia over 3 years. Results Our standard neurological evaluation (that included electrodiagnostic testing revealed that CD patients were 7.4 times more likely to develop large-fiber neuropathy than controls (p = 0.045, 7.1 times more likely to develop any type of neuromuscular condition (p = 0.001 and 5.1 times more likely to develop autonomic complaints (p = 0.027. UC patients were 5 times more likely to develop large-fiber neuropathy (p = 0.027 and 3.1 times more likely to develop any type of neuromuscular condition (p = 0.015. Conclusion In summary, this is the first study to prospectively establish that both CD and UC patients are more prone to neuromuscular diseases than patients with gastritis and dyspepsia.

  17. Hypnosis in the treatment of Morgellons disease: a case study.

    Gartner, Ashley M; Dolan, Sara L; Stanford, Matthew S; Elkins, Gary R

    2011-04-01

    Morgellons Disease is a condition involving painful skin lesions, fibrous growths protruding from the skin, and subcutaneous stinging and burning sensations, along with symptoms of anxiety, depression, fatigue, and memory and attention deficits. The etiological and physiological bases of these symptoms are unclear, making the diagnosis controversial and challenging to treat. There are currently no established treatments for Morgellons Disease. The following case example depicts treatment of a woman with Morgellons Disease using hypnotherapy. Data from this case example suggest that hypnotherapy is a promising intervention for the physical and psychological symptoms associated with Morgellons Disease.

  18. Effect of integrated responsive stimulation and nutrition interventions in the Lady Health Worker programme in Pakistan on child development, growth, and health outcomes: a cluster-randomised factorial effectiveness trial.

    Yousafzai, Aisha K; Rasheed, Muneera A; Rizvi, Arjumand; Armstrong, Robert; Bhutta, Zulfiqar A

    2014-10-04

    Stimulation and nutrition delivered through health programmes at a large scale could potentially benefit more than 200 million young children worldwide who are not meeting their developmental potential. We investigated the feasibility and effectiveness of the integration of interventions to enhance child development and growth outcomes in the Lady Health Worker (LHW) programme in Sindh, Pakistan. We implemented a community-based cluster-randomised effectiveness trial through the LHW programme in rural Sindh, Pakistan, with a 2 × 2 factorial design. We randomly allocated 80 clusters (LHW catchments) of children to receive routine health and nutrition services (controls; n=368), nutrition education and multiple micronutrient powders (enhanced nutrition; n=364), responsive stimulation (responsive stimulation; n=383), or a combination of both enriched interventions (n=374). The allocation ratio was 1:20 (ie, 20 clusters per intervention group). The data collection team were masked to the allocated intervention. All children born in the study area between April, 2009, and March, 2010, were eligible for enrolment if they were up to 2·5 months old without signs of severe impairments. Interventions were delivered by LHWs to families with children up to 24 months of age in routine monthly group sessions and home visits. The primary endpoints were child development at 12 and 24 months of age (assessed with the Bayley Scales of Infant and Toddler Development, Third Edition) and growth at 24 months of age. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT007159636. 1489 mother-infant dyads were enrolled into the study, of whom 1411 (93%) were followed up until the children were 24 months old. Children who received responsive stimulation had significantly higher development scores on the cognitive, language, and motor scales at 12 and 24 months of age, and on the social-emotional scale at 12 months of age, than did those who

  19. Building America Case Study: Compact Buried Ducts in a Hot-Humid Climate House, Lady's Island, South Carolina

    2016-02-01

    A system of compact, buried ducts provides a high-performance and cost-effective solution for delivering conditioned air throughout the building. This report outlines research activities that are expected to facilitate adoption of compact buried duct systems by builders. The results of this research would be scalable to many new house designs in most climates and markets, leading to wider industry acceptance and building code and energy program approval. The primary research question with buried ducts is potential condensation at the outer jacket of the duct insulation in humid climates during the cooling season. Current best practices for buried ducts rely on encapsulating the insulated ducts with closed-cell spray polyurethane foam insulation to control condensation and improve air sealing. The encapsulated buried duct concept has been analyzed and shown to be effective in hot-humid climates. The purpose of this project is to develop an alternative buried duct system that performs effectively as ducts in conditioned space - durable, energy efficient, and cost-effective - in a hot-humid climate (IECC warm-humid climate zone 3A) with three goals that distinguish this project: 1) Evaluation of design criteria for buried ducts that use common materials and do not rely on encapsulation using spray foam or disrupt traditional work sequences, 2) Establishing design criteria for compact ducts and incorporate those with the buried duct criteria to further reduce energy losses and control installed costs, and 3) Developing HVAC design guidance for performing accurate heating and cooling load calculations for compact buried ducts.

  20. Study on the correlation between the trace elements with cerebrovascular diseases

    Dazhong, Zhang; Mingsong, Tai; Suqing, Chen [Sichuan Univ., Chengdu, SC (China). Inst. of Nuclear Science and Technology; and others

    1990-11-01

    In the paper, the correlation between the cerebroscular diseases, as haemorrhage, cerebral atherosclerosis, cerebral embolism, with trace element contents in hair and tissues of controls and diseases has been studied by PIXE. Biochemistry test for diseased cerebral atheroselerosis patientes were done. The distinction between the controls and diseases were revealed.

  1. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

    Inzitari, Domenico; Pracucci, Giovanni; Poggesi, Anna

    2009-01-01

    cerebral infarcts and atrophy. MAIN OUTCOME MEASURE: Transition from no disability (defined as a score of 0 or 1 on the instrumental activities of daily living scale) to disability (score >/=2) or death over three year follow-up. Secondary outcomes were incident dementia and stroke. RESULTS: Over a mean...... follow-up period of 2.42 years (SD 0.97, median 2.94 years), information on the main outcome was available for 633 patients. The annual rate of transition or death was 10.5%, 15.1%, and 29.5%, respectively, for patients with mild, moderate, or severe age related changes in white matter (Kaplan-Meier log...

  2. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

    Inzitari, Domenico; Pracucci, Giovanni; Poggesi, Anna

    2009-01-01

    OBJECTIVE: To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes. DESIGN: Observational data collection and follow-up of a cohort of older people undergoing brain magnetic resonance imaging after non-disabling...... complaints. SETTING: 11 European centres. PARTICIPANTS: 639 non-disabled older patients (mean age 74.1 (SD 5.0), 45.1% men) in whom brain magnetic resonance imaging showed mild, moderate, or severe age related changes in white matter (Fazekas scale). Magnetic resonance imaging assessment also included...... cerebral infarcts and atrophy. MAIN OUTCOME MEASURE: Transition from no disability (defined as a score of 0 or 1 on the instrumental activities of daily living scale) to disability (score >/=2) or death over three year follow-up. Secondary outcomes were incident dementia and stroke. RESULTS: Over a mean...

  3. Iron lady, reflexiones sobre la imagen y el liderazgo. Iron lady, reflections about image and leadership

    María Arnal Canudo

    2012-01-01

    A través de diversas teorías sobre el liderazgo así como la influencia del cine en el legado visual y biográfico de algunas personalidades relevantes, este artículo analiza el liderazgo de Margaret Thatcher mostrado en la película Iron Lady, sobrenombre con el que se la conoce. El largometraje presenta la figura de la que fuera primera ministra de Gran Bretaña a través de los recuerdos de su protagonista, los factores y circunstancias personales que influyeron en su estilo de gobernar y lider...

  4. The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models

    Ferrari, Pietro; Day, Nicholas E; Boshuizen, Hendriek C

    2008-01-01

    BACKGROUND: International multicentre studies on diet and cancer are relatively new in epidemiological research. They offer a series of challenging methodological issues for the evaluation of the association between dietary exposure and disease outcomes, which can both be quite heterogeneous acro...

  5. Ladies of Charity: Forgotten Pioneers of Social Assistance in Mexico, 1863-1910

    Silvia Marina Arrom

    2007-10-01

    Full Text Available The Asociación de Señoras de la Caridad (Association of Ladies of Charity was one of the largest Mexican women's organizations during the Porfiriato. It mobilized thousands of lay women volun­teers throughout the country, helping hundreds of thousands of poor people, as they strengthened their Catholic faith and values. Besides visiting those in need both in their homes and in public hospitals and jails, these women created and managed their own schools, hospitals, nursing homes, and other welfare institutions, thus contributing to Mexican systems of education, health, and social assistance. Without challenging the social standards of their time, the ladies of Charity carried out novel practices for Mexican women, and expanded the traditional limits of the feminine world.

  6. USHERING IN THE STUDY AND TREATMENT OF PRECLINICAL ALZHEIMER DISEASE

    Langbaum, Jessica B.S.; Fleisher, Adam S.; Chen, Kewei; Ayutyanont, Napatkamon; Lopera, Francisco; Quiroz, Yakeel T.; Caselli, Richard J.; Tariot, Pierre N.; Reiman, Eric M.

    2014-01-01

    Researchers have begun to characterize the subtle biological and cognitive processes that precede the clinical onset of Alzheimer disease (AD), and to set the stage for accelerated evaluation of experimental treatments to delay the onset, reduce the risk of or completely prevent clinical decline. Here, we provide an overview of the experimental strategies, and brain imaging and cerebrospinal fluid biomarker measures that are used in early detection and tracking of AD, highlighting at-risk individuals who could be suitable for preclinical monitoring. We discuss how these advances have contributed to reconceptualization of AD as a sequence of biological changes that occur during progression from preclinical AD, to mild cognitive impairment and finally dementia, and we review recently proposed research criteria for preclinical AD. Advances in the study of preclinical AD have driven the recognition that efficacy of at least some AD therapies may depend on initiation of treatment before clinical manifestation of disease, leading to a new era of AD prevention research. PMID:23752908

  7. The prevalence of secondary diseases of the HIV patients in the Omsk region: cross sectional study

    Pasechnik, Oksana; Pitsenko, Natalia

    2014-01-01

    The prevalence of secondary diseases of the HIV infected patients who were under observation in medical organizations of Omsk region in 2013 has been studied. 16, 8% of HIV-infected patients had a wide spectrum of secondary diseases, mainly infectious etiology. In the structure of secondary infections the leading position was occupied by tuberculosis (32, 3%), candidiasis (24,4%), bacterial diseases (23,7%). The average risk of tuberculosis diseases is 24 cases for 1000 HIV-infected patients.

  8. The Study on the Thyroglobulin in Thyroid Diseases

    Kim, Suk Keun; Lim, Soo Duk; Lee, Mun Ho

    1970-01-01

    In recent with development of immuno-electrophoresis, more accurate analysis of the serum protein became possible. However, there is few reports in the literature which investigated the changes of the immunoglobulin compared with electrophoretically fractioned serum thyroglobulin in the patients with various thyroid diseases. The purpose of this report is to investigate the changes of thyroglobulin in various thyroid diseases by the method of immuno-electrophoresis and to compare the results with serum protein fractionated by the method of agar-gel micro-electrophoresis. Sera from 9 patients with diffuse toxic goiter, 2 nodular nontoxic goiter, 2 thyroiditis, 3 hypothyroidism, 1 thyroid cancer, 7 cystic degeneration of the thyroid gland, and 10 normal subject were taken. All cases were confirmed by various laboratory thyroid function tests and thyroid needle biopsy. Immuno-electrophoretic analysis of the serum were performed by Scheidegger's modified micro-immuno-electrophoretic method. The antiserum was obtained from the Travenol Laboratories International, Hyland Products Division and was rabbit anti-human thyroglobulin. Microscope slide agar-gel electrophoresis for serum protein fractionation was performed at 4 .deg. C using veronal buffer, pH 8.6 and ionic strength 0.05, with 54 volts and 2.8 mA for 60 minutes. The fractionated slide was stained with 0.1% thiazine red. The results were as follows: 1) Increase of immune-globulin macroglobulin (IgM), alphaglobulin, and immune-globulin A (IgA) by 95.8%, 100%, 29.2% respectively was found in the serum from various thyroid diseases. 2) Thyroglobulin fraction was found to be increased in 50%, no change in 41.7%, and no line in 8.3% with all of the various goiter patients. On the other hand, 10 normal control group showed only 2 cases of increase, 5 cases of no change and 3 cases of no line.

  9. Chronic obstructive airway diseases: Is the EDL sufficient? A study ...

    STG's) and Essential Drug List (EDL) in 1996 some of the traditional medication for the treatment of asthma and chronic obstructive pulmonary disease (COPD) were removed from the medication list, e.g. slow release oral theophylline.

  10. Adsorptive removal of congo red and sunset yellow dyes from water systems by lady finger stem

    Abbas, A.; Murtaza, S.; Ayub, R.; Rehman, R.; Zahid, A.

    2012-01-01

    Summary: In this research work two anionic dyes, i.e. Congo Red and Sunset Yellow were removed successfully from aqueous media by Lady Finger stem in batch mode. Operational conditions optimization showed that agitation speed and particle size did not affect much in adsorption of these dyes; but contact time, pH, adsorbent dose and temperature of system effects the adsorption rate. Optimized conditions of adsorption for Congo Red dye were: 40 minute contact time, 8.0 pH, 0.5 g adsorbent dose, 40-60 microns mesh sized particles, 150 rpm agitation speed and 50 degree C temperature. Whereas for Sunset Yellow optimized conditions were: 30 minute contact time, 2.0 pH, 2.5 g adsorbent dose, 20-40 microns mesh sized particles, 50 rpm agitation speed and 30 degree C temperature. Suitability of equilibrium data was modulated with Langmuir, Freundlich and Temkin models and found that both physisorption and chemisorption processes play important role in adsorption of these dyes by Lady Finger stem. The results demonstrated that Lady Finger stem can be efficiently employed on larger scale wastewater treatment. (author)

  11. Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS

    Macfarlane, Matthew Duncan; Looi, Jeffrey Chee Leong; Walterfang, Mark

    2013-01-01

    and falls in cross-sectional and follow-up studies. Frontostriatal (or frontosubcortical) brain circuits may serve many of these functions, with the caudate nuclei playing a role in convergence of cognitive functions. This study aimed to determine whether reduced caudate volume relates to cognitive...... functions (executive functions, memory functions and speed of processing) and WMC. We determined caudate nuclei volumes, through manual tracing, on a subgroup of the LADIS study (n=66) from four centres with baseline and 3-year follow-up MRI scans. Regression analysis was used to assess relationships...... between caudate volume, cognitive function and WMC. Severity of WMC did not relate to caudate volume. Smaller caudate volumes were significantly associated with poorer executive functioning at baseline and at 3 years, but were not associated with scores of memory or speed of processing. Thus, in patients...

  12. Chronic obstructive pulmonary disease prevalence in Lisbon, Portugal: The burden of obstructive lung disease study

    C. Bárbara

    2013-05-01

    Full Text Available Background: There is a great heterogeneity in the prevalence of Chronic Obstructive Pulmonary Disease (COPD across the world. The Burden of Obstructive Lung Disease (BOLD initiative was started to measure the prevalence of COPD in a standardized way. We aimed to estimate the prevalence of COPD in Portuguese adults aged 40 years or older of a target population of 2,700,000 in the Lisbon region, in accordance with BOLD protocol. Methods: A stratified, multi-stage random sampling procedure was used which included 12 districts. The survey included a questionnaire with information on risk factors for COPD and reported respiratory disease and a post-bronchodilator spirometry performed at survey centres. Results: For the 710 participants with questionnaires and acceptable spirometry, the overall weighted prevalence of GOLD stage I+ COPD was 14.2% (95% C.I. 11.1, 18.1, and stage II+ was 7.3% (95% C.I. 4.7, 11.3. Unweighted prevalence was 20.2% (95% C.I.17.4, 23.3 for stage I+ and 9.5% (95% C.I. 7.6, 11.9 for stage II+. Prevalence of COPD in GOLD stage II+ increased with age and was higher in men. The prevalence of GOLD stage I+ COPD was 9.2% (95% C.I. 5.9, 14.0 in never smokers versus 27.4% (95% C.I. 18.5, 38.5 in those who had smoked ≥20 pack-years. The agreement between previous doctor diagnosis and spirometric diagnosis was low, with 86.8% of underdiagnosed individuals. Conclusions: The 14.2% of COPD estimated prevalence indicates that COPD is a common disease in the Lisbon region. In addition, a large proportion of underdiagnosed disease was detected. The high prevalence of COPD with a high level of underdiagnosis, points to the need of raising awareness of COPD among health professionals, and requires more use of spirometry in the primary care setting. Resumo: Introdução: A prevalência da doença pulmonar obstrutiva crónica (DPOC apresenta valores muito heterogéneos em todo o mundo. A iniciativa Burden of Obstructive Lung

  13. Responses of growth of lady's fingers (Abelmoschus esculentus L.) to different treatments methods of dairy wastewater.

    Al-Dulaimi, Rana Ibrahim; Ismail, Norli; Ibrahim, Mahamad H

    2014-01-01

    Water is one of the most important precious resources found on the earth, and are most often affected by anthropogenic activities and by industry. Pollution caused by human beings and industries is a serious concern throughout the world. Population growth, massive urbanization, rapid rate of industrialization and modern techniques in agriculture have accelerated water pollution and led to the gradual deterioration of its quality. A large quantity of waste water disposed of at sea or on land has caused environmental problems which have led to environmental pollution, economic losses and chemical risks caused by the wastewater, and its impact on agriculture. However, waste water which contain nutrients and organic matter has possible advantages for agricultural purposes. Therefore, the presented study was undertaken to assess the impact of Dairy Effluent (treated and untreated waste water) on seed germination, seedling growth, dry matter production and the biochemical parameters of lady's fingers (Abelmoschus esculentus L.). A field experiment in a green house was conducted to use raw and treated dairy wastewater for watering lady's fingers (Abelmoschus esculentus L.). The plants were watered using (WW) raw dairy wastewater, (T1) chemicals treatment, (T2) physical treatment, (T3) dilution method treatment and tap water (TW) in pot experiments. Ten plants of each treatment /3 replicate were randomly selected and labelled for the collection of data. The data was collected sequentially, starting with chlorophyll content pre-harvest, vegetative qualities (shoot, root and seedling length) and dry matter quality (shoot and root dry matter) pos-tharvest. The effect was seen on the germination seed and growth of the plant. The results showed inhibitory effect from dairy effluent (WW) on seed germination and plant growth. Treatment with chemicals showed statistically significant differences with other treatments. Chemical treatment (TC2) at 20 mg/L Al2(SO4)3 and pH 6

  14. Childhood Heart Disease - A partnership model of integrated care

    Williams, Holly; Brooke, Mark

    2018-01-01

    HeartKids is a national charity supporting infants, children, young people and adults living with or impacted by congenital / childhood heart disease. For over 20 years HeartKids has worked in partnership with Lady Cilento Children's Hospital to deliver services and support to families.HeartKids supports families in hosptial and in the commuity with a suite of support programs lead by both health profesisonals and volunteers.  Critical to our model of care is a partnership with Lady Cilento C...

  15. Mortality due to noncommunicable diseases in Brazil, 1990 to 2015, according to estimates from the Global Burden of Disease study

    Deborah Carvalho Malta

    Full Text Available ABSTRACT CONTEXT AND OBJECTIVE: Noncommunicable diseases (NCDs are the leading health problem globally and generate high numbers of premature deaths and loss of quality of life. The aim here was to describe the major groups of causes of death due to NCDs and the ranking of the leading causes of premature death between 1990 and 2015, according to the Global Burden of Disease (GBD 2015 study estimates for Brazil. DESIGN AND SETTING: Cross-sectional study covering Brazil and its 27 federal states. METHODS: This was a descriptive study on rates of mortality due to NCDs, with corrections for garbage codes and underreporting of deaths. RESULTS: This study shows the epidemiological transition in Brazil between 1990 and 2015, with increasing proportional mortality due to NCDs, followed by violence, and decreasing mortality due to communicable, maternal and neonatal causes within the global burden of diseases. NCDs had the highest mortality rates over the whole period, but with reductions in cardiovascular diseases, chronic respiratory diseases and cancer. Diabetes increased over this period. NCDs were the leading causes of premature death (30 to 69 years: ischemic heart diseases and cerebrovascular diseases, followed by interpersonal violence, traffic injuries and HIV/AIDS. CONCLUSION: The decline in mortality due to NCDs confirms that improvements in disease control have been achieved in Brazil. Nonetheless, the high mortality due to violence is a warning sign. Through maintaining the current decline in NCDs, Brazil should meet the target of 25% reduction proposed by the World Health Organization by 2025.

  16. Systematic Review on the Definition of Allergic Diseases in Children : The MeDALL Study

    Pinart, Mariona; Albang, Richard; Maier, Dieter; Duran-Tauleria, Enric; Mena, Guillermo; Gimeno-Santos, Elena; Solà, Ivan; Garcia-Aymerich, Judith; Guerra, Stefano; Stein, Renato T; Benet, Marta; Carlsen, Kai-Håkon; Herr, Marie; Jacquemin, Bénédicte; Momas, Isabelle; Pin, Isabelle; Rancière, Fanny; Smit, Henriëtte A; Varraso, Raphaelle; Bonfill, Xavier; Keil, Thomas; Bousquet, Jean; Antó, Josep M

    2015-01-01

    BACKGROUND: During the last decades, a large number of phenotypes and disease classifications of allergic diseases have been proposed. Despite the heterogeneity across studies, no systematic review has been conducted on phenotype classification and the criteria that define allergic diseases. We

  17. The Congenital Heart Disease Genetic Network Study: Cohort description.

    Thanh T Hoang

    Full Text Available The Pediatric Cardiac Genomics Consortium (PCGC designed the Congenital Heart Disease Genetic Network Study to provide phenotype and genotype data for a large congenital heart defects (CHDs cohort. This article describes the PCGC cohort, overall and by major types of CHDs (e.g., conotruncal defects and subtypes of conotrucal heart defects (e.g., tetralogy of Fallot and left ventricular outflow tract obstructions (e.g., hypoplastic left heart syndrome. Cases with CHDs were recruited through ten sites, 2010-2014. Information on cases (N = 9,727 and their parents was collected through interviews and medical record abstraction. Four case characteristics, eleven parental characteristics, and thirteen parent-reported neurodevelopment outcomes were summarized using counts and frequencies and compared across CHD types and subtypes. Eleven percent of cases had a genetic diagnosis. Among cases without a genetic diagnosis, the majority had conotruncal heart defects (40% or left ventricular outflow tract obstruction (21%. Across CHD types, there were significant differences (p<0.05 in the distribution of all four case characteristics (e.g., sex, four parental characteristics (e.g., maternal pregestational diabetes, and five neurodevelopmental outcomes (e.g., learning disabilities. Several characteristics (e.g., sex were also significantly different across CHD subtypes. The PCGC cohort is one of the largest CHD cohorts available for the study of genetic determinants of risk and outcomes. The majority of cases do not have a genetic diagnosis. This description of the PCGC cohort, including differences across CHD types and subtypes, provides a reference work for investigators who are interested in collaborating with or using publically available resources from the PCGC.

  18. The Gestational Trophoblastic Diseases: A Ten Year Retrospective Study

    Razieh Mohammadjafari

    2010-01-01

    Full Text Available Background: Gestational trophoblastic disease (GTD defines a heterogenenous group ofinterrelated lesions that arise from the trophoblastic epithelium of the placenta. There are severalhistologically distinct types of GTD: hydatiform mole (complete or partial, persistant/invasivegestational trophoblastic neoplasia (GTN, choriocarcinoma and placenta site trophoblastictumors. The aim of this study was to determine the frequency and risk factors of GTD amongwomen admitted to Imam Khomeini Hospital in Ahvaz, Iran.Materials and Methods: This was a cross-sectional study conducted at Imam KhomeiniHospital in Ahvaz, Iran. All hospital records related to GTD (132 from 1996 until 2006 werereviewed. Demographic and histo-pathologic characteristics were extracted. Chi-square andFisher-exact tests were used to analyze all variables. P ≤ 0.05 was considered statisticallysignificant. SPSS, version 11 was used for statistical analysis.Results: The mean age of patients was 27.6 years. Most patients who presented with GTDwere of ages 18-35 years (71.3%. There was no relationship between age and hydatiformmole during the reproductive years. There were 28 (18.9% patients over the age 40, of which18 (15.90% of these had a complete hydatiform mole. Within this group, 9 (6.8% changedto a persistent mole. There was a significant relationship between age over 40 and completemole (p<0.02. The percentage of patients with blood groups A and O was the same (37.9%.There was a significant relationship between blood groups (O+ and A+ and complete mole(p<0.05.Conclusion: The most common age range for hydatiform mole was 18-35 years. Women overthe age of 40 had a more complete hydatiform mole, which is similar to the other countries.Age and blood group are two risk factors for hydatiform mole.

  19. Etiological and epidemiological studies on the red leaf disease of ...

    Diseased plants from the field had reduced root systems and had Neosartorya fischeri. Nematodes of the genera Aphelenchus, ... Plants grown from symptomatic suckers in a plant house with diffuse light intensity (7,440 lm m-2) and at 29 oC, recovered from RLD within 6 months. These plants, however, reddened when ...

  20. Study the relationship of erythropoietin and chronic obstructive pulmonary disease

    R.I. El-Korashy

    2012-07-01

    It also appeared that response to erythropoietin in COPD is probably blunted especially with increased severity of the condition. This might be considered as a contributing factor in the development of anemia in COPD which is considered as anemia of chronic disease.

  1. LA ARQUEOLOGÍA HISTÓRICA EN CANARIAS. EL YACIMIENTO SEPULCRAL DE LA IGLESIA DE NUESTRA SEÑORA DE LA CONCEPCIÓN DE SANTA CRUZ DE TENERIFE (Historical archaeology in the Canaries. The burial site of the church of Our Lady of the Conception in Santa Cruz de Tenerife

    Matilde Arnay de la Rosa

    2009-09-01

    Full Text Available En este estudio revisamos la situación actual de la Arqueología Histórica en las Islas Canarias, disciplina que, a diferencia de la americana, estaba poco desarrollada en las islas hasta hace unos 20 años. El reciente estudio de yacimientos históricos importantes ha modificado esta situación. Como ejemplo, comentamos algunos resultados derivados de la excavación de la iglesia de Nuestra Señora de la Concepción, en cuyo subsuelo se enterró a la población de Santa Cruz de Tenerife durante siglos. Pese a la pobre preservación de los esqueletos, ha sido posible inferir hábitos dietéticos, estado nutricional, exposición a tóxicos, y realizar estudios de DNA mitocondrial. El material recuperado (cerámica, pipas, crucifijos y adornos varios permite establecer estrechas relaciones con la colonización española del Nuevo Mundo. ENGLISH: This study includes an updated review of the current status of Historical Archaeology in the Canary Islands. Traditionally, in contrast with the situation in America, archaeological activity was devoted to studies on the prehistoric remains of population. In the last 20 years, excavation of some important historical sites has allowed the development of Historical Archaeology. As an example, we comment some results obtained from the excavation of the floor of the church of Our Lady of the Conception, where the deads of Santa Cruz de Tenerife were interred during centuries. Despite the poor preservation of the skeletons, it has been possible to infer dietary habits, toxic exposure, nutritional status and genetic lineages (mitochondrial DNA. Smoking pipes, ceramics and adornments associated with interments show a high similitude with those from colonial sites of the New World.

  2. Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease

    Riis, L; Vind, Ida; Politi, P

    2006-01-01

    BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) often affects patients in their fertile age. The aim of this study was to describe pregnancy outcome in a European cohort of IBD patients. As data are limited regarding the effect of pregnancy on disease course, our second objective was to inv...

  3. A study of mammographic appearance of the breast disease

    Cho, Kil Ho; Jung, Kyung Hee; Hwang, Mi Soo; Chang, Jae Chun; Kim, Myung Se; Shim, Min Chul; Min, Hyun Sik [College of Medicine, Yeung Nam University, Gyeongsan (Korea, Republic of)

    1985-08-15

    The history of the radiological examination of the breast has been long, and recently the methods for examining the breast are variable: mammography, thermography, xeroradiography, ultrasonography, water-path sonography, transillumination, mammary C.T., M.R imaging, infra-red scanning, nuclear medicine, and galactography. Most of these methods were not proven or have not been satisfied on their clinical testing but conventional mammography has been the gold standard for diagnosis of the breast cancer and no other method has reached its effectiveness. The authors performed mammography in 488 patients with breast abnormalities who had visited to Yeung Nam University hospital from May, 1983 to December, 1984. And we analyzed the mammographic findings and diagnostic accuracy in pathologically confirmed 53 cases by operations or biopsies. The results are as follows: 1. Among 16 cases of breast malignancies (1) the most prevalent age group is 6th decade (37.5%), followed by 5th decade (31.3%), (2) the most common pathologic type is ductal carcinoma (93.75%), (3) the masses are larger than 2cm in 8 cases, smaller than 2cm in 5 cases, and no visible mass is observed in 3 cases. 2. Among 37 cases of benign breast diseases, (1) the most prevalent age group is 4th and 5th decades (each 11 cases), and followed by 3rd decade (8 cases), (2) the most common disease is benign tumor (17 cases), followed by fibrocystic dysplasia (13 cases), and inflammating disease (7 cases), (3) radiologically visible masses are observed in 16 cases and the masses are smaller than 2cm in 11 cases. 3. The diagnostic accuracy of mammography compared with that of pathology, (1) in malignancy, the accuracy rate is 75% (12/16 cases), and 87% (32/37 cases) in benign diseases, (2) average accuracy rate is 81% (44/53 cases)

  4. A study of mammographic appearance of the breast disease

    Cho, Kil Ho; Jung, Kyung Hee; Hwang, Mi Soo; Chang, Jae Chun; Kim, Myung Se; Shim, Min Chul; Min, Hyun Sik

    1985-01-01

    The history of the radiological examination of the breast has been long, and recently the methods for examining the breast are variable: mammography, thermography, xeroradiography, ultrasonography, water-path sonography, transillumination, mammary C.T., M.R imaging, infra-red scanning, nuclear medicine, and galactography. Most of these methods were not proven or have not been satisfied on their clinical testing but conventional mammography has been the gold standard for diagnosis of the breast cancer and no other method has reached its effectiveness. The authors performed mammography in 488 patients with breast abnormalities who had visited to Yeung Nam University hospital from May, 1983 to December, 1984. And we analyzed the mammographic findings and diagnostic accuracy in pathologically confirmed 53 cases by operations or biopsies. The results are as follows: 1. Among 16 cases of breast malignancies (1) the most prevalent age group is 6th decade (37.5%), followed by 5th decade (31.3%), (2) the most common pathologic type is ductal carcinoma (93.75%), (3) the masses are larger than 2cm in 8 cases, smaller than 2cm in 5 cases, and no visible mass is observed in 3 cases. 2. Among 37 cases of benign breast diseases, (1) the most prevalent age group is 4th and 5th decades (each 11 cases), and followed by 3rd decade (8 cases), (2) the most common disease is benign tumor (17 cases), followed by fibrocystic dysplasia (13 cases), and inflammating disease (7 cases), (3) radiologically visible masses are observed in 16 cases and the masses are smaller than 2cm in 11 cases. 3. The diagnostic accuracy of mammography compared with that of pathology, (1) in malignancy, the accuracy rate is 75% (12/16 cases), and 87% (32/37 cases) in benign diseases, (2) average accuracy rate is 81% (44/53 cases)

  5. From The House with the Green Shutters to Our Lady of Perpetual Succour: the portrayal of alcohol in the modern Scottish novel.

    Beveridge, A W

    2017-03-01

    In modern Scottish literature alcohol is a recurrent subject; this paper examines the different ways it is portrayed with particular emphasis on the novel. It has been seen as the resort of the weak-minded and the cause of personal degradation. It has been portrayed as a response to and a symptom of social disintegration. It has been depicted as leading to delirium and psychosis. On a positive note it has been hailed as a source of inspiration and as a means of celebration. It has helped some troubled characters find the road to redemption. Along the way we encounter various literary stereotypes of the drinker, while the pub forms the backdrop to much of the action.

  6. Iron ladies, men of steel : The effects of gender stereotyping on the perception of male and female candidates are moderated by prototypicality

    Lammers, Joris; Gordijn, Ernestine H.; Otten, Sabine

    Women remain a minority in politics. In nearly all countries, including parliamentary, democracies, women are still underrepresented in national parliament and other representative institutions. Research has argued that there is a bias against women in elections. Here we study the process behind

  7. CASE REPORT Thirty years old lady with nephrotic syndrome: a ...

    CASE REPORT. Thirty years old lady with nephrotic syndrome: a case of biopsy proven lupus nephritis in Tanzania. FRANCIS FREDRICK1,2*, PASCHAL J. RUGGAJO2,3,GYAVIIRA MAKANGA3, CHARLES K. SHIJA3, MIKAEL. AMDEMARIAM3, BELSON RUGWIZAGONGA4 and JAMES N. KITINYA4. 1Department of ...

  8. Annual change in the rate of participation in breast cancer screening through active encouragement of sports participation. A survey of women participants at the annual meetings of the Pink Ribbon Ladies' Tennis Tournament organized by the Japan Women's Tennis Players' League

    Shimada, Naoko; Nozue; Etsuko; Fukuda, Mamoru; Sawai, Kiyoshi; Kasumi, Fujio

    2007-01-01

    In March 2002, an initial attempt was made to decrease breast cancer mortality by the Japan Society of Breast Health, by means of encouraging participation in sports. This was followed by other similar events. The present study was designed to examine whether these kinds of sport-associated events are actually effective for increasing the screening participation rate. We hoped that the results would reveal practical ways of organizing such programs. One of these activities, the All Japan Women's Tennis Players' League, has called for amateur players to participate in an annual meeting of the Pink Ribbon Ladies' Tennis Tournament since 2003. A survey of their knowledge about breast cancer and their will to participate in breast cancer screening has been carried out annually in 2003, 2004 and 2005, by asking the participants to respond to our questionnaires. As a result, the number of participants has increased: from 7,201 women in 2003, to 7,846 in 2004 and to 8,572 in 2005. The questionnaires included items about participation in breast cancer screening, performance of self-examination, and participation in mammography screening. The participation rate increased year by year. The participation rate at mammography screening was 21% in 2003, and this increased to 26% in 2005. Thus this kind of sports event appears to promote knowledge about breast cancer screening and to increase the participation rate. On the other hand, it was found that the rate of self-examination decreased from 53% to 22%. Therefore problems that need to be addressed in the future include not only increasing women's motivation to undergo screening, but also the selection of appropriate screening methods, their combination, and distribution of accurate information. (author)

  9. Crowdsourcing Disease Biomarker Discovery Research: The IP4IC Study.

    Chancellor, Michael B; Bartolone, Sarah N; Veerecke, Andrew; Lamb, Laura E

    2018-05-01

    Biomarker discovery is limited by readily assessable, cost efficient human samples available in large numbers that represent the entire heterogeneity of the disease. We developed a novel, active participation crowdsourcing method to determine BP-RS (Bladder Permeability Defect Risk Score). It is based on noninvasive urinary cytokines to discriminate patients with interstitial cystitis/bladder pain syndrome who had Hunner lesions from controls and patients with interstitial cystitis/bladder pain syndrome but without Hunner lesions. We performed a national crowdsourcing study in cooperation with the Interstitial Cystitis Association. Patients answered demographic, symptom severity and urinary frequency questionnaires on a HIPAA (Health Insurance Portability and Accountability Act) compliant website. Urine samples were collected at home, stabilized with a preservative and sent to Beaumont Hospital for analysis. The expression of 3 urinary cytokines was used in a machine learning algorithm to develop BP-RS. The IP4IC study collected a total of 448 urine samples, representing 153 patients (147 females and 6 males) with interstitial cystitis/bladder pain syndrome, of whom 54 (50 females and 4 males) had Hunner lesions. A total of 159 female and 136 male controls also participated, who were age matched. A defined BP-RS was calculated to predict interstitial cystitis/bladder pain syndrome with Hunner lesions or a bladder permeability defect etiology with 89% validity. In this novel participation crowdsourcing study we obtained a large number of urine samples from 46 states, which were collected at home, shipped and stored at room temperature. Using a machine learning algorithm we developed BP-RS to quantify the risk of interstitial cystitis/bladder pain syndrome with Hunner lesions, which is indicative of a bladder permeability defect etiology. To our knowledge BP-RS is the first validated urine biomarker assay for interstitial cystitis/bladder pain syndrome and one of the

  10. First Lady Hillary Clinton returns to KSC for second launch attempt

    1999-01-01

    Entering the Banana Creek viewing site, First Lady Hillary Rodham Clinton is joined by NASA Administrator Daniel Goldin (right), and in the background, Deputy Director of Business Operations Jim Jennings (far left) and Director of Installation Operations Marv Jones (right, behind Goldin). Mrs. Clinton and others are at the site to watch the second launch attempt of STS-93. Moments before the first scheduled launch, July 20, STS-93 was scrubbed at the T-7 second mark in the countdown due to an indication of a high concentration of hydrogen in an aft engine compartment. The reading proved to be a false alarm. The launch was rescheduled for July 22 at 12:28 a.m. Much attention has been generated over STS-93 due to Commander Eileen M. Collins, the first woman to serve as commander of a Shuttle mission. The primary payload of the five-day mission is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe.

  11. Linguistic ability in early life and the neuropathology of Alzheimer's disease and cerebrovascular disease. Findings from the Nun Study.

    Snowdon, D A; Greiner, L H; Markesbery, W R

    2000-04-01

    Findings from the Nun Study indicate that low linguistic ability in early life has a strong association with dementia and premature death in late life. In the present study, we investigated the relationship of linguistic ability in early life to the neuropathology of Alzheimer's disease and cerebrovascular disease. The analyses were done on a subset of 74 participants in the Nun Study for whom we had handwritten autobiographies completed some time between the ages of 19 and 37 (mean = 23 years). An average of 62 years after writing the autobiographies, when the participants were 78 to 97 years old, they died and their brains were removed for our neuropathologic studies. Linguistic ability in early life was measured by the idea (proposition) density of the autobiographies, i.e., a standard measure of the content of ideas in text samples. Idea density scores from early life had strong inverse correlations with the severity of Alzheimer's disease pathology in the neocortex: Correlations between idea density scores and neurofibrillary tangle counts were -0.59 for the frontal lobe, -0.48 for the temporal lobe, and -0.49 for the parietal lobe (all p values < 0.0001). Idea density scores were unrelated to the severity of atherosclerosis of the major arteries at the base of the brain and to the presence of lacunar and large brain infarcts. Low linguistic ability in early life may reflect suboptimal neurological and cognitive development, which might increase susceptibility to the development of Alzheimer's disease pathology in late life.

  12. Neutropenia, neutrophil dysfunction, and inflammatory bowel disease in glycogen storage disease type Ib : Results of the European Study on Glycogen Storage Disease Type I

    Visser, G; Rake, JP; Fernandes, J; Labrune, P; Leonard, JV; Moses, S; Ullrich, K; Smit, GPA

    Objective: To investigate the incidence, the severity, and the course of neutropenia, neutrophil dysfunction, and inflammatory bowel disease (IBD) in glycogen storage disease (GSD) type Ib. Method: As part of a collaborative European Study on GSD type I, a retrospective registry was established in

  13. Orthopantomographic study of the alveolar bone level on periodontal disease

    Lee, Ki Sik; You, Dong Soo [College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1972-11-15

    The author had measured the alveolar bone level of periodontal disease on 50 cases of orthopantomogram to detect the degree of alveolar bone resorption of both sexes of Korean. The results were obtained as follows; 1. Alveolar bone resorption of mesial and distal portion was similar in same patient. 2. The order of alveolar bone resorption was mandibular anterior region, posterior region, canine and premolar region of both jaws. 3. The degree of alveolar bone destruction was severe in shorter root length than longer one. 4. The degree of alveolar bone resorption was severe in fourth decades.

  14. Orthopantomographic study of the alveolar bone level on periodontal disease

    Lee, Ki Sik; You, Dong Soo

    1972-01-01

    The author had measured the alveolar bone level of periodontal disease on 50 cases of orthopantomogram to detect the degree of alveolar bone resorption of both sexes of Korean. The results were obtained as follows; 1. Alveolar bone resorption of mesial and distal portion was similar in same patient. 2. The order of alveolar bone resorption was mandibular anterior region, posterior region, canine and premolar region of both jaws. 3. The degree of alveolar bone destruction was severe in shorter root length than longer one. 4. The degree of alveolar bone resorption was severe in fourth decades.

  15. Solution properties of a heteropolysaccharide extracted from pumpkin (Cucurbita pepo, lady godiva).

    Song, Yi; Zhao, Jing; Ni, Yuanying; Li, Quanhong

    2015-11-05

    A water-soluble galactoglucofucomannan was extracted from pumpkin (Cucurbita pepo, lady godiva variety). GC-MS analysis indicated that the polysaccharide was composed of 1,6-linked-glucosyl, 1,2,6-linked-mannosyl, 1,3,6-linked-mannosyl, 1,2,6-linked-galactosyl, 1,2,6-linked-galactosyl, terminal fucosyl and terminal glucose. The solution properties of the polysaccharide were studied systematically by using size-exclusion chromatography combined with multi-angle laser light scattering, viscometry and dynamic light scattering at 25 °C. The weight average molecular masses (Mw), intrinsic viscosity [η], radius of gyration (Rg) and hydrodynamic radius (Rh) were found to be 12.7 × 10(5)g/mol, 780 ml/g, 68 nm and 116 nm, respectively. The fraction dimension and value of ρ (Rg/Rh) of the polysaccharide revealed that it existed in a sphere-like conformation in distilled water. The dependence of zero shear specific viscosity on the coil overlap parameter was analyzed using different models. Furthermore, degradation of samples upon autoclaving has been observed and quantified by intrinsic viscosity determination and SEC-MALLS. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. The first lady almoner: the appointment, position, and findings of Miss Mary Stewart at the Royal Free Hospital, 1895-99.

    Cullen, Lynsey T

    2013-10-01

    This article examines the professional roots of the hospital almoner, a position which has been widely neglected in medical history. The first almoner was Miss Mary Stewart, a former Charity Organization Society employee, appointed at the Royal Free Hospital of central London in 1895. The Royal Free was a charitable hospital which offered free medical treatment to patients considered morally deserving but unable to afford medical care elsewhere. The role expected of Stewart was to means test patients in order to ensure that only those deemed "appropriate" received free medical treatment, and to establish the extent to which the hospital was being abused by those who could afford to contribute toward their medical care. While in office, Stewart continually reshaped the role of almoner. She fashioned the position into that of a medical social worker and undertook such duties as referring patients to other means of medical and charitable assistance, visiting patients' homes, and training almoners for positions at other voluntary hospitals. Through the examination of Mary Stewart's Almoners Report Book, this article considers the circumstances of her appointment, the role she performed, and the findings of her investigations.

  17. The First Lady Almoner: The Appointment, Position, and Findings of Miss Mary Stewart at the Royal Free Hospital, 1895–99

    Cullen, Lynsey T.

    2013-01-01

    This article examines the professional roots of the hospital almoner, a position which has been widely neglected in medical history. The first almoner was Miss Mary Stewart, a former Charity Organization Society employee, appointed at the Royal Free Hospital of central London in 1895. The Royal Free was a charitable hospital which offered free medical treatment to patients considered morally deserving but unable to afford medical care elsewhere. The role expected of Stewart was to means test patients in order to ensure that only those deemed “appropriate” received free medical treatment, and to establish the extent to which the hospital was being abused by those who could afford to contribute toward their medical care. While in office, Stewart continually reshaped the role of almoner. She fashioned the position into that of a medical social worker and undertook such duties as referring patients to other means of medical and charitable assistance, visiting patients' homes, and training almoners for positions at other voluntary hospitals. Through the examination of Mary Stewart's Almoners Report Book, this article considers the circumstances of her appointment, the role she performed, and the findings of her investigations. PMID:22474098

  18. The contribution of twin studies to the understanding of the aetiology of asthma and atopic diseases

    Thomsen, Simon F

    2015-01-01

    The prevalence of asthma and other atopic diseases has increased markedly during the past decades and the reasons for this are not fully understood. Asthma is still increasing in many parts of the world, notably in developing countries, and this emphasizes the importance of continuing research...... aimed at studying the aetiological factors of the disease and the causes of its increase in prevalence. Twin studies enable investigations into the genetic and environmental causes of individual variation in multifactorial diseases such as asthma. Thorough insight into these causes is important...... as this will ultimately guide the development of preventive strategies and targeted therapies. This review explores the contribution of twin studies to the understanding of the aetiology of asthma and atopic diseases....

  19. Job stress, absenteeism and coronary heart disease European cooperative study (the JACE study): Design of a multicentre prospective study

    Houtman, I.; Kornitzer, M.; Smet, P. de; Koyuncu, R.; Backer, G. de; Pelfrene, E.; Romon, M.; Boulenguez, C.; Ferrario, M.; Origgi, G.; Sans, S.; Perez, I.; Wilhelmsen, L.; Rosengren, A.; Isacsson, S.-O.; Östergren, P.-O.

    1999-01-01

    Background: The motives, objectives and design of a multicentre prospective study on job stress, absenteeism and coronary heart disease in Europe (the JACE study) is presented in this paper. Some specific gaps in the reviewed literature are explicitly tapped into by the JACE study. Its objectives

  20. “Okay ladies, now let’s get in formation!”: Music Videos and the Construction of Cultural Memory

    Bertens Laura M. F.

    2017-08-01

    Full Text Available This paper explores strategies for constructing and perpetuating cultural memory through music videos, using Beyonce’s Formation (2016 and Janelle Monae’s Many Moons (2008 and Q.U.E.E.N. (2013 as case studies. The medium’s idiosyncrasies create unique ways of communicating and remembering, explored here within a framework of Cultural Studies and Memory Studies. Easy dissemination and the limited length of most videos ensure a large, diverse audience. The relative freedom from narrative constraints enables the director to create original imagery, and most importantly, the medium allows an intricate blending of performance and performativity; while the videos evidently are performances, they are strongly performative as well, not only with respect to gender and ethnicity but in significant ways also cultural memory. A close reading of Beyonce’s video Formation shows how she explicitly does the cultural memory of the New Orleans flooding. The videos by Monae are shown to produce counter-memories, relying heavily on the strategy of Afrofuturism. As such, these densely woven networks of visual symbols become palimpsests of black lived experience and cultural memory, passed on to millions of viewers.

  1. Studies on the pathogenesis of Aleutian disease of mink

    Mueller-Peddinghaus, R.; Meyer zu Schwabedissen, H.; Kalden, J.R.; Trautwein, G.; Ueberschaer, S.

    1980-01-01

    Aleutian disease (AD) of mink most closely resembles systemic lupus erythematosus (SLE) in man; both are immune complex disease. In experimental AD serum immune complexes are determined by the 125 J-C 1 q-binding test using human C 1 q. Mink (n = 12) infected intraperitoneally with Aleutian disease virus (ADV), grown in fetal mink kidney cells, developed during the course of infection a mean of 125 I-C 1 q serum binding equivalent to 3.62 +- 1.68 mg./ml. aggr. HGG. (aggregated human immunoglobulin). Sera of mink (n = 8) which were infected with ADV grown in L-cells showed a less marked 125 I-C 1 q binding with a mean equivalent to 2.52 +- 1.43 mg./ml. aggr. HGG. In contrast control animals (n = 8) treated with non-ADV-infected mink epidermal fibroblasts or Eagle's minimal essential medium substituted with fetal calf serum only bound 125 I-C 1 q equivalent to 1.02 +- 0.99 mg./ml. aggr. HGG. In mink infected with ADV propagated in fetal mink kidney cells a constant increase in the 125 I-C 1 q serum binding occurred from the 4th to the 7th and 13th week after ADV infection. Mink which were infected with ADV propagated in mouse L-cells exhibited a different pattern of the 125 I-C 1 q serum binding capacity with a sharp increase from the 4th to the 7th week, followed by a decline towards the 13th week post infection. The serum 125 I-C 1 q binding capacity of all experimental animal groups exhibited at different times of the experiment a significant correlation with the presence of hypergammaglobulinaemia and raised ADV-antibody titers. From the data obtained it appears that the 125 I-C 1 q binding test, utilizing human C 1 q, is a suitable method for the detection of circulating serum immune complexes in mink during the course of ADV-infection. (orig.) [de

  2. The Age of Studies and Reports: Selected Elements Concerning the Background of Encounters Defining the Power of Education

    Tašner, Veronika; Gaber, Slavko

    2016-01-01

    In the present paper, we discuss the time before the "age of reports". Besides the Coleman Report in the period of Coleman, the Lady Plowden Report also appeared, while there were important studies in France (Bourdieu & Passeron, 1964; Peyre, 1959) and studies that inaugurated comprehensive education in Nordic countries. We focus on…

  3. Lady Morgan in Italy: A Traveller with an Agenda

    Donatella Abbate Badin

    2016-06-01

    Full Text Available Lady Morgan (née Sydney Owenson was a professional Irish travellerand travel-writer, who spent over a year on the peninsula. The travelogueItaly (1821 she was commissioned to write on the basis of the reputationshe had acquired as a novelist (e.g. The Wild Irish Girl, 1806 anda socio-political writer (France, 1817, left a mark on Italy and on theunderstanding of Italy in Great Britain. Her writings, in fact, helpeddisseminate the ideal of a unified Italy and influence British and Irishpublic opinion in favour of Italy’s aspirations to cast off foreign or domesticautocratic rule. Moreover, she used her travelogue to serve thecause of Ireland disguising a patriotic message about her home countryunder her many sallies about nationalism and the right to self-determinationconcerning Italy. The political impact of her book, unusualfor a travel account written by a woman, was enhanced by Morgan’sradical ideology, the gender bias of her observations and her originalmethods. The present article purposes to examine Morgan’s double,feminine and masculine, approach of mixing solid documentation withapparently frivolous notes originating in the feminine domain of societynews, commentary on the domestic scene and emotional reporting onsocial and historical events. Distrusting male-authored official history,Morgan gave a central place in her work to the informal sources fromwhich she gathered her insights about Italy. Analysing how she came toobtain the contemporary input for elaborating her ideas will be the aimof this chapter which will dwell on the more worldly aspects of Morgan’ssojourn in the peninsula focussing on the company she kept, theactivities she partook of, the events of a domestic nature she witnessed.

  4. The Romance of Lady Isabel Burton : the story of her life / told in part by herself and in part by W.H. Wilkins

    Burton, Isabel, Lady, 1831-1896

    2004-01-01

    ... and ribbons The blaze of lights the odour of flowers the perfumes the diamonds and the magnificent dresses of the cream of the British aristocracy smote upon my senses all was new to me and all was sweet ...

  5. Innovative measures to combat rare diseases in China: The national rare diseases registry system, larger-scale clinical cohort studies, and studies in combination with precision medicine research.

    Song, Peipei; He, Jiangjiang; Li, Fen; Jin, Chunlin

    2017-02-01

    China is facing the great challenge of treating the world's largest rare disease population, an estimated 16 million patients with rare diseases. One effort offering promise has been a pilot national project that was launched in 2013 and that focused on 20 representative rare diseases. Another government-supported special research program on rare diseases - the "Rare Diseases Clinical Cohort Study" - was launched in December 2016. According to the plan for this research project, the unified National Rare Diseases Registry System of China will be established as of 2020, and a large-scale cohort study will be conducted from 2016 to 2020. The project plans to develop 109 technical standards, to establish and improve 2 national databases of rare diseases - a multi-center clinical database and a biological sample library, and to conduct studies on more than 50,000 registered cases of 50 different rare diseases. More importantly, this study will be combined with the concept of precision medicine. Chinese population-specific basic information on rare diseases, clinical information, and genomic information will be integrated to create a comprehensive predictive model with a follow-up database system and a model to evaluate prognosis. This will provide the evidence for accurate classification, diagnosis, treatment, and estimation of prognosis for rare diseases in China. Numerous challenges including data standardization, protecting patient privacy, big data processing, and interpretation of genetic information still need to be overcome, but research prospects offer great promise.

  6. Knowing the Environment in Rio Bonito: A Fun and Educational Practice at the College Our Lady of Nazareth, Nova Friburgo-Rj

    Inajara Schuaber Gomes

    2015-06-01

    Full Text Available This research was developed in the city of New Friburgo, more precisely in the seventh section – Lumiar – Rio Bonito. The inexistence in the region of educational actions aimed at understanding, reflecting and offering information to the population on the main environmental subjects has leaded to an environmental diagnosis, to identify the local community problems and, later, to develop educational environmental activities at municipal school Nossa Senhora de Nazareth. To attain this aim, the selected educational strategy was story telling. The research instrument was a questionnaire addressed to the families and to the teachers. Based on the principal detected problems, the ones related to environmental issues were selected, such as: river pollution; the release of solid residues in not appropriate places and the armed hunting. Those subjects were discussed with the local school students through story telling. Other playful educational activities were also developed. Finally, it could be observed that, not only the stories, but also the complementary activities, have helped the students in the environmental education work, considering that besides showing interest in the subject, they participated intensely, reflected, changed and built knowledge.

  7. [Rasagiline is not for all Parkinson disease patients: the ADAGIO study].

    Laar, T. van; Boon, A.J.; Bloem, B.R.

    2010-01-01

    Rasagiline is a MAO-B inhibitor that is currently registered for the symptomatic treatment of Parkinson disease. The ADAGIO trial studied the potential disease-modifying properties of rasagiline in 1100 patients with Parkinson disease, using an innovative 'delayed start' design. Patients were

  8. Forecasting and Analyzing the Disease Burden of Aged Population in China, Based on the 2010 Global Burden of Disease Study

    Chengzhen Bao

    2015-06-01

    Full Text Available Background: Forecasting the disease burden of the elderly will contribute to make a comprehensive assessment about physical and mental status of the elderly in China and provide a basis for reducing the negative consequences of aging society to a minimum. Methods: This study collected data from a public database online provided by Global Burden of Disease Study 2010. Grey model GM (1, 1 was used to forecast all-cause and disease-specific rates of disability adjusted life years (DALYs in 2015 and 2020. Results: After cross-sectional and longitudinal analysis, we found that non-communicable diseases (NCDs were still the greatest threats in the elderly, followed by injuries. As for 136 predicted causes, more than half of NCDs increased obviously with age, less than a quarter of communicable, material, neonatal, and nutritional disorders or injuries had uptrend. Conclusions: The findings display the health condition of the Chinese elderly in the future, which will provide critical information for scientific and sociological researches on preventing and reducing the risks of aging society.

  9. A controlled experiment on the impact of software structure on maintainability

    Rombach, Dieter H.

    1987-01-01

    The impact of software structure on maintainability aspects including comprehensibility, locality, modifiability, and reusability in a distributed system environment is studied in a controlled maintenance experiment involving six medium-size distributed software systems implemented in LADY (language for distributed systems) and six in an extended version of sequential PASCAL. For all maintenance aspects except reusability, the results were quantitatively given in terms of complexity metrics which could be automated. The results showed LADY to be better suited to the development of maintainable software than the extension of sequential PASCAL. The strong typing combined with high parametrization of units is suggested to improve the reusability of units in LADY.

  10. The household contact study design for genetic epidemiological studies of infectious diseases

    Catherine eStein

    2013-04-01

    Full Text Available Most genetic epidemiological study designs fall into one of two categories: family-based and population-based (case-control. However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.

  11. Atlantic mackerel and Horse mackerel egg survey 2016: Dutch participation on board FV Atlantic Lady: May

    Damme, van, C.J.G.

    2016-01-01

    From 10 till 25 May 2016 IMARES carried out a mackerel and horse mackerel egg survey on board the FV Atlantic Lady. This survey was part of the international mackerel and horse mackerel egg survey coordinated by ICES. The Redersvereniging voor de Zeevisserij (RVZ) asked IMARES to carry out this survey. Numbers of mackerel eggs in the samples were low, lower compared to previous surveys. Most mackerel eggs were found along the 200m depth contour of the continental slope. Most of the adult mack...

  12. Progress of PET imaging in the study of neural stem cell transplantation treating Parkinson's disease

    Tan Haibo; Liu Xingdang

    2004-01-01

    PET imaging has important value in the study of neural stem cell transplantation treating Parkinson's disease, especial in the evaluation of the effect, the study of treating mechanisms and the comparation of effect in different transplantation places. PET imaging as a non-invasive method plays a more and more important role in the study of neural stem cell transplantation treating Parkinson's disease. (authors)

  13. Revisiting the “Intentional Fallacy” as a Political Mechanism in Angela Carter’s “The Loves of Lady Purple”

    Ryan-Sautour, Michelle

    2014-01-01

    The Intentional Fallacy,” essai de William K. Wimsatt Jr. et Monroe C. Beardsley écrit en 1946, a marqué un tournant dans le débat autour de la figure de l’auteur dans la littérature, débat qui continue de hanter la critique contemporaine. Roland Barthes a déclaré “La Mort de l’auteur ” en 1968, et la critique continue de traiter de la question de l’identité de l’auteur avec prudence, car compte tenu des théories de langages modernes, il y a consensus que toute tentative de cerner l’intentio...

  14. The oral microbiota of Irish children in health and disease: a longitudinal and cross sectional study

    Hurley, Eimear

    2017-01-01

    The oral cavity harbours a very rich and diverse microbial community. In the last decade, the oral microbiota of children and adults has been studied in detail using continuously developing DNA sequencing methods. In particular focusing on the oral microbiome changes in the presence of diseases such as dental caries, periodontal disease and the relationship of the oral microbiome with oral health and disease states. The overall aim of these studies was to unravel the complexity of the oral ec...

  15. Diverticular disease and the risk of colon cancer - a population-based case-control study.

    Granlund, J; Svensson, T; Granath, F; Hjern, F; Ekbom, A; Blomqvist, P; Schmidt, P T

    2011-09-01

    Colon cancer and diverticular disease are most common in the Western world and their incidences tend to increase with advancing age. The association between the diseases remains unclear. To analyse the risk of colon cancer after hospitalisation for diverticular disease. Nationwide case-control study. A total of 41,037 patients with colon cancer during 1992-2006, identified from the Swedish Cancer Register were included. Each case was matched with two control subjects. From the Swedish Inpatient Register, cases and control subjects hospitalised for diverticular disease were identified. Odds ratios (OR) and confidence intervals for receiving a diagnosis of colon cancer after hospital discharge for diverticular disease were calculated. Colon cancer mortality was compared between patients with or without diverticular disease. Within 6months after an admission due to diverticular disease, OR of having a colon cancer diagnosis were up to 31.49 (19.00-52.21). After 12 months, there was no increased risk. The number of discharges for diverticular disease did not affect the risk. Colon cancer mortality did not differ between patients with and without diverticular disease. Diverticular disease does not increase the risk of colon cancer in the long term, and a history of diverticular disease does not affect colon cancer mortality. The increased risk of colon cancer within the first 12months after diagnosing diverticular disease is most likely due to surveillance and misclassification. Examination of the colon should be recommended after a primary episode of symptomatic diverticular disease. © 2011 Blackwell Publishing Ltd.

  16. Concurrent primary hyperparathyroidism and pheochromocytoma in a Chinese lady with neurofibromatosis type 1

    Cheuk-Lik Wong

    2018-04-01

    Full Text Available We report a case of elderly Chinese lady with neurofibromatosis type-1 presenting with longstanding palpitation, paroxysmal hypertension and osteoporosis. Biochemical testing showed mild hypercalcaemia with non-suppressed parathyroid hormone level suggestive of primary hyperparathyroidism, and mildly elevated urinary fractionated normetanephrine and plasma-free normetanephrine pointing to a catecholamine-secreting pheochromocytoma/paraganglioma. Further scintigraphic investigation revealed evidence of a solitary parathyroid adenoma causing primary hyperparathyroidism and a left pheochromocytoma. Resection of the parathyroid adenoma and pheochromocytoma resulted in normalization of biochemical abnormalities and hypertension. The rare concurrence of primary hyperparathyroidism and pheochromocytoma in neurofibromatosis type-1 is discussed.

  17. Ladies from hell, Aberdeen free gardeners, and the Russian influenza: an anthropometric analysis of WWI-era Scottish soldiers and civilians.

    Riggs, Paul; Cuff, Timothy

    2013-01-01

    We analyze data on the height of Scottish men, both civilians and members of the military forces serving in World War I measured in the 1910s, in order to provide another window into the biological well-being of late nineteenth-century birth cohorts. The evidence indicates that rural residents still had a distinct height advantage over their urban counterparts and that military men displayed a slower growth profile than did civilians, but mean heights for the two groups of adults were similar. Mean stature for both groups is well above those found by Floud for British troops born in the 1880s and greater than that of Scottish convicts from the 1830s. Men who were in utero between 1889 and 1893 were slightly stunted, "marked for life" by an encounter with the Russian influenza which struck the region repeatedly. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. Lady Liberty and Godfather Death as candidates for linguistic relativity? Scrutinizing the gender congruency effect on personified allegories with explicit and implicit measures.

    Bender, Andrea; Beller, Sieghard; Klauer, Karl Christoph

    2016-01-01

    Linguistic relativity--the idea that language affects thought by way of its grammatical categorizations--has been controversially debated for decades. One of the contested cases is the grammatical gender of nouns, which is claimed to affect how their referents are conceptualized (i.e., as rather female or male in congruence with the grammatical gender of the noun), especially when used allegorically. But is this association strong enough to be detected in implicit measures, and, if so, can we disentangle effects of grammatical gender and allegorical association? Three experiments with native speakers of German tackled these questions. They revealed a gender congruency effect on allegorically used nouns, but this effect was stronger with an explicit measure (assignment of biological sex) than with an implicit measure (Extrinsic Affective Simon Task) and disappeared in the implicit measure when grammatical gender and allegorical associations were set into contrast. Taken together, these findings indicate that the observed congruency effect was driven by the association of nouns with personifications rather than by their grammatical gender. In conclusion, we also discuss implications of these findings for linguistic relativity.

  19. Lady Justice and the Corporate Visor: An Application of Routine Activity Theory as a Synthesized Theoretical Framework for Explaining Corporate Crime

    Anderson, James

    2000-01-01

    ... social problems of violent and property crimes. However, the criminological community has all but ignored this useful theoretical tool as an apropos explanatory framework for our most insidious and prolific crime problem: corporate crime...

  20. Uma dama argentina em terras yankees: os Recuerdos de viaje, de Eduarda Mansilla An argentinean lady in yankee land: the travel memoirs of Eduarda Mansilla

    Stella Maris Scatena Franco

    2008-12-01

    Full Text Available Neste artigo analiso o relato de viagem da escritora argentina Eduarda Mansilla aos Estados Unidos, intitulado Recuerdos de viaje (1882. Integrante de uma camada social privilegiada e oriunda de uma família tradicional pertencente à elite política argentina, a autora expõe um ponto de vista particular sobre as condutas das norte-americanas com quem conviveu em sua viagem, mostrando com isso sua própria concepção sobre os papéis sociais femininos.In this article I analyze the account of a journey the Argentinean writer Eduarda Mansilla made to the United States, which she called Travel Memoirs (1882. Eduarda Mansilla was part of a privileged social class and came from a traditional family belonging to the political elite in Argentina, she exposed a particular point of view on the behavior of the North Americans who she lived with during her travel, unveiling her own conceptions on female social roles.

  1. Will Coral Islands maintain their growth over the next century? A deterministic model of sediment availability at Lady Elliot Island, Great Barrier Reef.

    Sarah Hamylton

    Full Text Available A geomorphic assessment of reef system calcification is conducted for past (3200 Ka to present, present and future (2010-2100 time periods. Reef platform sediment production is estimated at 569 m3 yr-1 using rate laws that express gross community carbonate production as a function of seawater aragonite saturation, community composition and rugosity and incorporating estimates of carbonate removal from the reef system. Key carbonate producers including hard coral, crustose coralline algae and Halimeda are mapped accurately (mean R2 = 0.81. Community net production estimates correspond closely to independent census-based estimates made in-situ (R2 = 0.86. Reef-scale outputs are compared with historic rates of production generated from (i radiocarbon evidence of island deposition initiation around 3200 years ago, and (ii island volume calculated from a high resolution island digital elevation model. Contemporary carbonate production rates appear to be remarkably similar to historical values of 573 m3 yr-1. Anticipated future seawater chemistry parameters associated with an RCP8.5 emissions scenario are employed to model rates of net community calcification for the period 2000-2100 on the basis of an inorganic aragonite precipitation law, under the assumption of constant benthic community character. Simulations indicate that carbonate production will decrease linearly to a level of 118 m3 yr-1 by 2100 and that by 2150 aragonite saturation levels may no longer support the positive budgetary status necessary to sustain island accretion. Novel aspects of this assessment include the development of rate law parameters to realistically represent the variable composition of coral reef benthic carbonate producers, incorporation of three dimensional rugosity of the entire reef platform and the coupling of model outputs with both historical radiocarbon dating evidence and forward hydrochemical projections to conduct an assessment of island evolution

  2. Will Coral Islands maintain their growth over the next century? A deterministic model of sediment availability at Lady Elliot Island, Great Barrier Reef.

    Hamylton, Sarah

    2014-01-01

    A geomorphic assessment of reef system calcification is conducted for past (3200 Ka to present), present and future (2010-2100) time periods. Reef platform sediment production is estimated at 569 m3 yr-1 using rate laws that express gross community carbonate production as a function of seawater aragonite saturation, community composition and rugosity and incorporating estimates of carbonate removal from the reef system. Key carbonate producers including hard coral, crustose coralline algae and Halimeda are mapped accurately (mean R2 = 0.81). Community net production estimates correspond closely to independent census-based estimates made in-situ (R2 = 0.86). Reef-scale outputs are compared with historic rates of production generated from (i) radiocarbon evidence of island deposition initiation around 3200 years ago, and (ii) island volume calculated from a high resolution island digital elevation model. Contemporary carbonate production rates appear to be remarkably similar to historical values of 573 m3 yr-1. Anticipated future seawater chemistry parameters associated with an RCP8.5 emissions scenario are employed to model rates of net community calcification for the period 2000-2100 on the basis of an inorganic aragonite precipitation law, under the assumption of constant benthic community character. Simulations indicate that carbonate production will decrease linearly to a level of 118 m3 yr-1 by 2100 and that by 2150 aragonite saturation levels may no longer support the positive budgetary status necessary to sustain island accretion. Novel aspects of this assessment include the development of rate law parameters to realistically represent the variable composition of coral reef benthic carbonate producers, incorporation of three dimensional rugosity of the entire reef platform and the coupling of model outputs with both historical radiocarbon dating evidence and forward hydrochemical projections to conduct an assessment of island evolution through time

  3. Rare small intestinal volvulus from entrapment in hepato-diaphragmatic adhesions in a 45-year-old lady.

    Olaoye, Iyiade Olatunde; Adesina, Micheal Dapo

    2016-12-20

    Small intestinal volvulus is rare in adults and rarely caused by string adhesions between the liver and the diaphragm. Similar adhesions were described in Fitz-Hugh-Curtis syndrome. We report a 45-year-old lady with small intestinal volvulus from entrapment of a loop in string adhesions between the liver and the diaphragm. Her plain radiographs showed a significant shadow of the trapped loop. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2016.

  4. Association of plasma phytosterol concentrations with incident coronary heart disease Data from the CORA study, a case-control study of coronary artery disease in women

    Windler, Eberhard; Zyriax, Birgit-Christiane; Kuipers, Folkert; Linseisen, Jakob; Boeing, Heiner

    Aims: Phytosterols have been proposed to be atherogenic. This research investigates whether plasma concentrations of phytosterols correlate with the manifestation of coronary heart disease. Methods and results: The CORA study compares clinical, biochemical, and lifestyle factors in consecutive pre-

  5. Ladies without lamps: nurses in Bangladesh.

    Zaman, Shahaduz

    2009-03-01

    In this article, I explore the experiences and concerns of Bangladeshi nurses. I have based this on a larger ethnographic study that was conducted in a ward of a government teaching hospital in Bangladesh. The study shows how the values and norms of Bangladeshi society have shaped the life of Bangladeshi nurses, that they do scarcely any nursing work, and that they suffer from various negative social images. I argue, through this article, that the role, image, and concerns of Bangladeshi nurses have changed dramatically from the ideal image of nursing, and are dissimilar from the ways nursing is practiced in many other parts of the world.

  6. Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study.

    Sokka, Tuulikki; Toloza, Sergio; Cutolo, Maurizio; Kautiainen, Hannu; Makinen, Heidi; Gogus, Feride; Skakic, Vlado; Badsha, Humeira; Peets, Tõnu; Baranauskaite, Asta; Géher, Pál; Ujfalussy, Ilona; Skopouli, Fotini N; Mavrommati, Maria; Alten, Rieke; Pohl, Christof; Sibilia, Jean; Stancati, Andrea; Salaffi, Fausto; Romanowski, Wojciech; Zarowny-Wierzbinska, Danuta; Henrohn, Dan; Bresnihan, Barry; Minnock, Patricia; Knudsen, Lene Surland; Jacobs, Johannes Wg; Calvo-Alen, Jaime; Lazovskis, Juris; Pinheiro, Geraldo da Rocha Castelar; Karateev, Dmitry; Andersone, Daina; Rexhepi, Sylejman; Yazici, Yusuf; Pincus, Theodore

    2009-01-01

    Gender as a predictor of outcomes of rheumatoid arthritis (RA) has evoked considerable interest over the decades. Historically, there is no consensus whether RA is worse in females or males. Recent reports suggest that females are less likely than males to achieve remission. Therefore, we aimed to study possible associations of gender and disease activity, disease characteristics, and treatments of RA in a large multinational cross-sectional cohort of patients with RA called Quantitative Standard Monitoring of Patients with RA (QUEST-RA). The cohort includes clinical and questionnaire data from patients who were seen in usual care, including 6,004 patients at 70 sites in 25 countries as of April 2008. Gender differences were analyzed for American College of Rheumatology Core Data Set measures of disease activity, DAS28 (disease activity score using 28 joint counts), fatigue, the presence of rheumatoid factor, nodules and erosions, and the current use of prednisone, methotrexate, and biologic agents. Women had poorer scores than men in all Core Data Set measures. The mean values for females and males were swollen joint count-28 (SJC28) of 4.5 versus 3.8, tender joint count-28 of 6.9 versus 5.4, erythrocyte sedimentation rate of 30 versus 26, Health Assessment Questionnaire of 1.1 versus 0.8, visual analog scales for physician global estimate of 3.0 versus 2.5, pain of 4.3 versus 3.6, patient global status of 4.2 versus 3.7, DAS28 of 4.3 versus 3.8, and fatigue of 4.6 versus 3.7 (P < 0.001). However, effect sizes were small-medium and smallest (0.13) for SJC28. Among patients who had no or minimal disease activity (0 to 1) on SJC28, women had statistically significantly higher mean values compared with men in all other disease activity measures (P < 0.001) and met DAS28 remission less often than men. Rheumatoid factor was equally prevalent among genders. Men had nodules more often than women. Women had erosions more often than men, but the statistical significance

  7. Constitutional hepatic dysfunction (Gilbert's disease), about eleven cases studied in the Hospital Obrero de Lima

    León Navarro, Oswaldo

    2014-01-01

    We report eleven cases of Constitutional Hepatic dysfunction (Gilbert's disease), studied at the Department of Gastroenterology of the Hospital Obrero de Lima. We place this disease in the group of non Chronicles Hemolytic jaundice due to congenital defects in bilirubin metabolism. It is noted, according to the new concepts of bilirubin metabolism, the pathogenic mechanism of this disease is related to deficient activity of glucuronyltransferase, the enzyme responsible for bilirubin conjugati...

  8. Lady Health Workers (LHWs as Flag Bearers for Children with Disabilities in Pakistan

    Ghazala Rafique

    2012-06-01

    Full Text Available Purpose: This study explores the perceptions, knowledge and attitudes of LHWs towards children with disabilities in Pakistan. It considers the feasibility of utilising the LHWs for prevention, early identification and management of disabilities for these children in the community.Methods: Two Focus Group Discussions (FGDs were conducted with 15 Lady Health Workers (LHWs, and two In Depth Interviews (IDIs with LHWs of both a semi-urban and a rural community of Pakistan.Results: LHWs were found to have major concerns and strong emotions regarding children with disabilities. They also revealed the insensitive attitude of community members towards these children. While they understood the major types and magnitude of disabilities better than lay persons, they lacked the knowledge to manage these disabilities. Consanguineous marriages were identified as the main cause of disabilities. LHWs reported that education and health facilities were lacking in semi-urban and rural areas, and demanded that the government provide these facilities for the children. They also expressed their willingness to work for these children, provided they had the approval of higher authorities and were given proper training.Conclusions: This qualitative exploratory study recommends that the existing primary health system be reviewed, and the possibility of introducing community based rehabilitation services, utilising LHWs’ services for children with disabilities, be examined. In this regard, it is imperative to assess the existing training modules of LHWs and to introduce modules on prevention, early identification, and management of children with disabilities. It is also necessary to employ mass media to spread awareness about persons with disabilities.

  9. Dynamic distribution patterns of ribosomal DNA and chromosomal evolution in Paphiopedilum, a lady's slipper orchid

    Albert Victor A

    2011-09-01

    Full Text Available Abstract Background Paphiopedilum is a horticulturally and ecologically important genus of ca. 80 species of lady's slipper orchids native to Southeast Asia. These plants have long been of interest regarding their chromosomal evolution, which involves a progressive aneuploid series based on either fission or fusion of centromeres. Chromosome number is positively correlated with genome size, so rearrangement processes must include either insertion or deletion of DNA segments. We have conducted Fluorescence In Situ Hybridization (FISH studies using 5S and 25S ribosomal DNA (rDNA probes to survey for rearrangements, duplications, and phylogenetically-correlated variation within Paphiopedilum. We further studied sequence variation of the non-transcribed spacers of 5S rDNA (5S-NTS to examine their complex duplication history, including the possibility that concerted evolutionary forces may homogenize diversity. Results 5S and 25S rDNA loci among Paphiopedilum species, representing all key phylogenetic lineages, exhibit a considerable diversity that correlates well with recognized evolutionary groups. 25S rDNA signals range from 2 (representing 1 locus to 9, the latter representing hemizygosity. 5S loci display extensive structural variation, and show from 2 specific signals to many, both major and minor and highly dispersed. The dispersed signals mainly occur at centromeric and subtelomeric positions, which are hotspots for chromosomal breakpoints. Phylogenetic analysis of cloned 5S rDNA non-transcribed spacer (5S-NTS sequences showed evidence for both ancient and recent post-speciation duplication events, as well as interlocus and intralocus diversity. Conclusions Paphiopedilum species display many chromosomal rearrangements - for example, duplications, translocations, and inversions - but only weak concerted evolutionary forces among highly duplicated 5S arrays, which suggests that double-strand break repair processes are dynamic and ongoing. These

  10. Childhood IQ and cardiovascular disease in adulthood: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies

    Hart, C.L.; Taylor, M.D.; Davey Smith, G.; Whalley, L.J.; Starr, J.M.; Hole, D.J.; Wilson, V.; Deary, I.J.

    2004-01-01

    This study investigated the influence of childhood IQ on the relationships between risk factors and cardiovascular disease (CVD), coronary heart disease (CHD) and stroke in adulthood. Participants were from the Midspan prospective cohort studies which were conducted on adults in Scotland in the 1970s. Data on risk factors were collected from a questionnaire and at a screening examination, and participants were followed up for 25 years for hospital admissions and mortality. 938 Midspan partici...

  11. Management of concomitant hyperparathyroidism and thyroid diseases in the elderly patients: a retrospective cohort study.

    Panarese, Alessandra; D'Andrea, Vito; Pontone, Stefano; Favoriti, Pasqualino; Pironi, Daniele; Arcieri, Stefano; Filippini, Angelo; Sorrenti, Salvatore

    2017-02-01

    Thyroid disease and hyperparathyroidism are the most common endocrine disorders. The incidence of thyroid disease in patients with hyperparathyroidism ranges in the different series from 17 to 84%, and thyroid cancer occurs with an incidence ranging from 2 to 15%. The aim of our study was to analyze the management of elderly patients with concomitant thyroid and parathyroid disease in order to define the best surgical therapeutic strategy and avoid reoperations associated with a higher risk of complications. All consecutive patients (64 patients, age range 60-75 years), undergoing surgery for hyperparathyroidism, from January 2011 to June 2014, were retrospectively evaluated. Enrolled patients were divided into two study groups of patients affected by hyperparathyroidism with or without a concomitant thyroid disease. Out of 64 patients enrolled in our study (24 men, age range 60-75 years), affected by hyperparathyroidism, 34 had an associated thyroid disease and were treated with total thyroidectomy and parathyroidectomy. The group, who underwent parathyroidectomy associated with thyroidectomy, had no greater complications than the group receiving only parathyroidectomy. Thyroid disease must be excluded in patients affected by hyperparathyroidism. It is difficult to determine whether hyperparathyroidism can be considered a risk factor for thyroid disease, but an accurate preoperative study is essential for a surgery able to treat both thyroid and parathyroid disease. In this way, we avoid the elderly patient, with associated morbidity and increased surgical risk, to undergo a reoperation for thyroid disease, burdened with major complications.

  12. Exploratory study into the awareness of heart diseases among Emirati women (UAE) and their health seeking behaviour- a qualitative study.

    Khan, Sarah; Khoory, Ayesha; Al Zaffin, Dhabia; Al Suwaidi, Meera

    2016-11-07

    Cardiovascular diseases were the leading cause of death in women in the United Arab Emirates (UAE) in 2010. The UAE is expected to experience a tripling of heart diseases in the next two decades as risk factors for heart diseases increase. Research shows that first year survival rates of younger women suffering from a heart attack are lower than in men. Women present with a wider range of symptoms for heart diseases than men; non-recognition of atypical symptoms may explain the delay in seeking treatment and poor prognosis following heart diseases in women. No known study on awareness of heart diseases among women has been carried out in the Middle Eastern region. Social constructionist and interpretivist epistemological approaches have been considered in this qualitative study to explore the awareness of heart diseases and the health seeking behavior of Emirati women. Convenience sampling was used to recruit 41 Emirati women. Three focus groups and six in-depth semi-structured interviews were conducted to obtain data. Thematic content analysis was applied to the data following transcription and translation of recordings. Emirati women had limited knowledge on heart diseases. Women were generally unaware of the atypical symptoms, commonly experienced by women however they identified most risk factors associated with heart diseases. Lack of awareness of disease severity and symptoms, sociocultural influences and distrust in the healthcare system were considered the main barriers to seeking prompt treatment. This study clearly identified gaps and inaccuracies in knowledge of heart diseases, which could contribute to delayed health seeking action and possibly poorer prognosis among Emirati women. Absence of initiatives to educate women on cardiovascular diseases in UAE has erroneously deemed it a less serious concern among Emirati women. The findings from this study provide clear indications of the need to increase accountability of the healthcare system and to

  13. Becoming an Engineer or a Lady Engineer

    Liebrand, Janwillem; Udas, Pranita Bhushan

    2017-01-01

    In this article, using the Department of Irrigation in Nepal as a case study, we argue that professional performance in irrigation engineering and water resources development is gendered and normalised as ‘masculine’. In Nepal, the masculinity of professional performance in irrigation engineering is

  14. The ideal epidemiological intervention study model on chronic non-infectious diseases - the way forward?

    Jensen, Olaf Chresten

    to modify the specific risk factors for cardiovascular diseases, diabetes, hypertension, hyperlipidaemia and obesity. The objective here is to present the methodological gold standard for the intervention studies and to discuss how to improve the intervention studies and programs. Material and Methods...

  15. From biological anthropology to applied public health: epidemiological approaches to the study of infectious disease.

    Albalak, Rachel

    2009-01-01

    This article describes two large, multisite infectious disease programs: the Tuberculosis Epidemiologic Studies Consortium (TBESC) and the Emerging Infections Programs (EIPs). The links between biological anthropology and applied public health are highlighted using these programs as examples. Funded by the Centers for Disease Control and Prevention (CDC), the TBESC and EIPs conduct applied public health research to strengthen infectious disease prevention and control efforts in the United States. They involve collaborations among CDC, public health departments, and academic and clinical institutions. Their unique role in national infectious disease work, including their links to anthropology, shared elements, key differences, strengths and challenges, is discussed.

  16. A randomized study of the prevention of acute graft-versus-host disease

    Ramsay, N.K.C.; Kersey, J.H.; Robison, L.L.; McGlave, P.B.; Woods, W.G.; Krivit, W.; Kim, T.H.; Goldman, A.I.; Nesbit, M.E. Jr.

    1982-01-01

    Acute graft-versus-host disease is a major problem in allogeneic bone-marrow transplantation. We performed a randomized study to compare the effectiveness of two regimens in the prevention of acute graft-versus-host disease. Thirty-five patients received methotrexate alone, and 32 received methotrexate, antithymocyte globulin, and prednisone. Of the patients who received methotrexate alone, 48 percent had acute graft-versus-host disease, as compared with 21 per cent of those who received methotrexate, antithymocyte globulin, and prednisone (P = 0.01). The age of the recipient was a significant factor in the development of acute graft-versus-host disease: Older patients had a higher incidence of the disease (P = 0.001). We conclude that the combination of methotrexate, antithymocyte globulin, and prednisone significantly decreased the incidence of acute graft-versus-host disease and should be used to prevent this disorder in patients receiving allogeneic marrow transplants

  17. Effect of childbirth on the course of Crohn's disease; results from a retrospective cohort study in the Netherlands

    Smink, M.; Lotgering, F.K.; Albers, L.; Jong, D.J. de

    2011-01-01

    BACKGROUND: Pregnant women with Crohn's disease needs proper counselling about the effect of pregnancy and childbirth on their disease. However, Literature about the effect of childbirth on Crohn's disease is limited. This study examined the effect of childbirth on the course of Crohn's disease and

  18. A phenomenological study on resilience of the elderly suffering from chronic disease: a qualitative study

    Hassani P

    2017-02-01

    Full Text Available Parkhide Hassani,1 Fatemeh-Sadat Izadi-Avanji,2 Mahnaz Rakhshan,3 Hamid Alavi Majd4 1Department of Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Nursing, School of Nursing and Midwifery, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran; 4Department of Biostatistics, Facility of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background: Resilience is a key factor in improving health and attenuating problems caused by chronic diseases in the elderly. Having a clear understanding of its meaning in a specific population can be of great help in taking efficient steps toward better health services. Given the lack of information in this regard, the aim of this study was to understand the meaning of resilience for hospitalized older people who experience chronic conditions.Methods: The study was carried out as a qualitative work based on a descriptive phenomenological approach. The participants were selected purposefully, so that 22 elderly with chronic disease were interviewed in 24 sessions. The collected data were recorded and analyzed through Colaizzi’s method.Results: Four themes were extracted from the interviews as follows: 1 “meaning of resilience in the participants’ experiences” with subthemes of “the art of overcoming pain and suffering”, “adapt to health problem of senescence”, “accepting life with the chronic disease”, and “patience and trust in God”; 2 “growth context as a prologue of resilience” with subthemes of “growth background”; 3 “external factors contributing to resilience” with subthemes of “welfare”, “received support”, “deprivation and shortage”, and “attitudes toward an elderly with health problem”; and 4

  19. The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.

    Peng, Xinxia; Alföldi, Jessica; Gori, Kevin; Eisfeld, Amie J; Tyler, Scott R; Tisoncik-Go, Jennifer; Brawand, David; Law, G Lynn; Skunca, Nives; Hatta, Masato; Gasper, David J; Kelly, Sara M; Chang, Jean; Thomas, Matthew J; Johnson, Jeremy; Berlin, Aaron M; Lara, Marcia; Russell, Pamela; Swofford, Ross; Turner-Maier, Jason; Young, Sarah; Hourlier, Thibaut; Aken, Bronwen; Searle, Steve; Sun, Xingshen; Yi, Yaling; Suresh, M; Tumpey, Terrence M; Siepel, Adam; Wisely, Samantha M; Dessimoz, Christophe; Kawaoka, Yoshihiro; Birren, Bruce W; Lindblad-Toh, Kerstin; Di Palma, Federica; Engelhardt, John F; Palermo, Robert E; Katze, Michael G

    2014-12-01

    The domestic ferret (Mustela putorius furo) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission. Here we describe the 2.41 Gb draft genome assembly of the domestic ferret, constituting 2.28 Gb of sequence plus gaps. We annotated 19,910 protein-coding genes on this assembly using RNA-seq data from 21 ferret tissues. We characterized the ferret host response to two influenza virus infections by RNA-seq analysis of 42 ferret samples from influenza time-course data and showed distinct signatures in ferret trachea and lung tissues specific to 1918 or 2009 human pandemic influenza virus infections. Using microarray data from 16 ferret samples reflecting cystic fibrosis disease progression, we showed that transcriptional changes in the CFTR-knockout ferret lung reflect pathways of early disease that cannot be readily studied in human infants with cystic fibrosis disease.

  20. MP3s, rebundled debt, and performative economics: deferral, derivatives, and digital commodity fetishism in Lady Gaga’s spectacle of excess

    Kustritz, A.

    2012-01-01

    Lady Gaga’s rise to fame in the wake of the global financial crisis highlights the contradictions of late late capitalism in both the financial sector and the music industry. Both Gaga and second level economic units like derivatives rely on deferral, parody, and an ever-widening gap between the

  1. The importance of studying sex differences in disease: The example of multiple sclerosis.

    Golden, Lisa C; Voskuhl, Rhonda

    2017-01-02

    To date, scientific research has often focused on one sex, with assumptions that study of the other sex would yield similar results. However, many diseases affect males and females differently. The sex of a patient can affect the risk for both disease susceptibility and progression. Such differences can be brought to the laboratory bench to be investigated, potentially bringing new treatments back to the clinic. This method of research, known as a "bedside to bench to bedside" approach, has been applied to studying sex differences in multiple sclerosis (MS). Females have greater susceptibly to MS, while males have worse disease progression. These two characteristics of the disease are influenced by the immune system and the nervous system, respectively. Thus, sex differences in each system must be studied. Personalized medicine has been at the forefront of research recently, and studying sex differences in disease fits with this initiative. This review will discuss the known sex differences in MS and highlight how investigating them can lead to new insights and potential treatments for both men and women. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  2. The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases

    Reijs, B.L.; Teunissen, C.E.; Goncharenko, N.; Betsou, F.; Blennow, K.; Baldeiras, I.; Brosseron, F.; Cavedo, E.; Fladby, T.; Froelich, L.; Gabryelewicz, T.; Gurvit, H.; Kapaki, E.; Koson, P.; Kulic, L.; Lehmann, S.; Lewczuk, P.; Lleo, A.; Maetzler, W.; Mendonca, A. de; Miller, A.M.; Molinuevo, J.L.; Mollenhauer, B.; Parnetti, L.; Rot, U.; Schneider, A.; Simonsen, A.H.; Tagliavini, F.; Tsolaki, M.; Verbeek, M.M.; Verhey, F.R.J.; Zboch, M.; Winblad, B.; Scheltens, P.; Zetterberg, H.; Visser, P.J.

    2015-01-01

    Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid

  3. Prevalence of chronic diseases at the onset of inflammatory arthritis: a population-based study.

    Ursum, J.; Korevaar, J.C.; Twisk, J.W.R.; Peters, M.J.L.; Schellevis, F.G.; Nurmohamed, M.T.; Nielen, M.M.J.

    2013-01-01

    Objective. Little is known about the presence of chronic morbidity in inflammatory arthritis (IA) patients at disease onset. Previous studies have been mainly performed in established IA patients or they focus on isolated co-morbid diseases. Our aim was to determine the prevalence of chronic

  4. Serum apolipoprotein e level is not increased in Alzheimer's disease : The Rotterdam study

    Slooter, A.J.C.; Knijff, P. de; Hofman, A.; Cruts, M.; Breteler, M.M.B.; Broeckhoven, C. van; Havekes, L.M.; Duijn, C.M. van

    1998-01-01

    The APOE*4 allele of the apolipoprotein E gene (APOE) is an important risk factor for Alzheimer's disease. It has been suggested that levels of apolipoprotein E (apoE) in plasma are increased in Alzheimer's disease. In this population-based study, we found that serum apoE levels were lower in

  5. Burden of ischemic heart diseases in Iran, 1990-2010: Findings from the Global Burden of Disease study 2010

    Mohammad Reza Maracy

    2015-01-01

    Full Text Available Background: Cardiovascular diseases are viewed worldwide as one of the main causes of death.This study aims to report the burden of ischemic heart diseases (IHDs in Iran by using data of the global burden of disease (GBD study, 1990-2010. Materials and Methods: The GBD study 2010 was a systematic effort to provide comprehensive data to calculate disability-adjusted life years (DALYs for diseases and injuries in the world. Years of life lost (YLLs due to premature mortality were computed on the basis of cause-of-death estimates, using Cause of Death Ensemble model (CODEm. Years lived with disability (YLDs were assessed by the multiplication of prevalence, the disability weight for a sequel, and the duration of symptoms. A systematic review of published and unpublished data was performed to evaluate the distribution of diseases, and consequently prevalence estimates were calculated with a Bayesian meta-regression method (DisMod-MR. Data from population-based surveys were used for producing disability weights. Uncertainty from all inputs into the calculations of DALYs was disseminated by Monte Carlo simulation techniques. Results: The age-standardized IHDs DALY specified rate decreased 31.25% over 20 years from 1990 to 2010 [from 4720 (95% uncertainty interval (UI: 4,341-5,099 to 3,245 (95% UI: 2,810-3,529 person-years per 100,000]. The decrease were 38.14% among women and 26.87% among men. The age-standardized IHDs death specefied rate decreased by 21.17% [from 222 95% UI: 207-243 (to 175 (95% UI:152-190 person-years per 100,000] in both the sexes. The age-standardized YLL and YLD rates decreased 32.05% and 4.28%, respectively, in the above period. Conclusion: Despite decreasing age-standardized IHD of mortality, YLL, YLD, and DALY rates from 1990 to 2010, population growth and aging increased the global burden of IHD. YLL has decreased more than IHD deaths and YLD since 1990 but IHD mortality remains the greatest contributor to disease burden.

  6. Phenylketonuria patients' and their parents' acceptance of the disease: multi-centre study.

    Witalis, Ewa; Mikoluc, Bożena; Motkowski, Radoslaw; Szyszko, Justyna; Chrobot, Agnieszka; Didycz, Bozena; Lange, Agata; Mozrzymas, Renata; Milanowski, Andrzej; Nowacka, Maria; Piotrowska-Depta, Mariola; Romanowska, Hanna; Starostecka, Ewa; Wierzba, Jolanta; Skorniewska, Magdalena; Wojcicka-Bartlomiejczyk, Barbara Iwona; Gizewska, Maria

    2016-11-01

    Phenylketonuria (PKU) still poses a therapeutic challenge for patients and medical professionals. The aim of the study was to assess both patients' and their parents' acceptance of the disease. The study included 218 PKU patients and 178 parents of PKU children who were enrolled in the study on the basis of questionnaire data. Regarding attitude towards the disease, our study demonstrated that 63 (28.9 %) PKU patients did not accept the disease. Patients who found accepting the disease difficult, more frequently perceived themselves as inferior/different in comparison with their peers. In total, 36 % of patients did not want their friends to be aware of their condition, while only 18 % of parents believed that their children's peers should not know about their disease. In total, 42 % of parents wanted to talk to other parents of PKU children and only 13 % to a doctor. Only 20 % of patients saw the need to discuss their condition with a doctor. In total, 8 % of children, regardless of age, and 14 % of parents preferred to talk to a psychologist. Our data demonstrated that disease acceptance played an essential role in patients' social integration. The study also indicated the need to overcome communication barriers between patients and their healthy peers and for patients to find the courage to be open about the disease. The importance of support groups for PKU families and the significance of strict cooperation between patients and their families with PKU treatment teams were also revealed.

  7. Lady Astor's Campaign for Nursery Schools in Britain, 1930-1939: Attempting to Valorize Cultural Capital in a Male-Dominated Political Field

    Brehony, Kevin J.

    2009-01-01

    This article examines the work of Lady Nancy Astor (1879-1964) in campaigning for nursery education and nursery schools in Britain from the late 1920s until the Second World War. Arguably no elected politician in England at any time, including the present, has identified themselves more closely with the cause of nursery schooling in Britain.…

  8. Endometriosis research: animal models for the study of a complex disease.

    Tirado-González, Irene; Barrientos, Gabriela; Tariverdian, Nadja; Arck, Petra C; García, Mariana G; Klapp, Burghard F; Blois, Sandra M

    2010-11-01

    Endometriosis is a common gynaecological disease that is characterized and defined as the presence of endometrial tissue outside the uterus, causing painful periods and subfertility in approximately 10% of women. After more than 50 years of research, little is known about the mechanisms underlying the development and establishment of this condition. Animal models allow us to study the temporal sequence of events involved in disease establishment and progression. Also, because this disease occurs spontaneously only in humans and non-human primates and there are practical problems associated with studying the disease, animal models have been developed for the evaluation of endometriosis. This review describes the animal models for endometriosis that have been used to date, highlighting their importance for the investigation of disease mechanisms that would otherwise be more difficult to elucidate, and proposing new alternatives aimed at overcoming some of these limitations. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  9. Church ladies, good girls, and locas

    Collins, Pamela Y; von Unger, Hella; Armbrister, Adria

    2008-01-01

    Inner city women with severe mental illness may carry multiple stigmatized statuses. In some contexts these include having a mental illness, being a member of an ethnic minority group, being an immigrant, being poor, and being a woman who does not live up to gendered expectations. These potentially stigmatizing identities influence both the way women’s sexuality is viewed and their risk for HIV infection. This qualitative study applies the concept of intersectionality to facilitate understanding of how these multiple identities intersect to influence women’s sexuality and HIV risk. We report the firsthand accounts of 24 Latina women living with severe mental illness in New York City. In examining the interlocking domains of these women’s sexual lives, we find that the women seek identities that define them in opposition to the stigmatizing label of “loca” (Spanish for crazy) and bestow respect and dignity. These identities have unfolded through the additional themes of “good girls” and “church ladies”. Therefore, inspite of their association with the “loca”, the women also identify with faith and religion (“church ladies”) and uphold more traditional gender norms (“good girls”) that are often undermined by the realities of life with a severe mental illness and the stigma attached to it. However, the participants fall short of their gender ideals and engage in sexual relationships that they experience as disempowering and unsatisfying. The effects of their multiple identities as poor Latina women living with severe mental illness in an urban ethnic minority community are not always additive, but the interlocking effects can facilitate increased HIV risks. Interventions should acknowledge women’s multiple layers of vulnerability, both individual and structural, and stress women’s empowerment in and beyond the sexual realm. PMID:18423828

  10. CT study in Alzheimer's disease

    Arai, Heii; Kobayashi, Kazunari; Ikeda, Kenji; Nagao, Yoshiko; Ogihara, Ryuji; Kosaka, Kenji [Tokyo Metropolitan Matsuzawa Hospital (Japan)

    1983-01-01

    Cerebral atrophy on CT was studied in 18 patients with clinically diagnosed Alzheimer's disease and in 14 healthy age-matched subjects as the control. The patients with Alzheimer's disease were divided into three groups of Stages I, II and III, according to their clinical symptoms. The study of the measurement method disclosed that the computerized measurement involving calculation of the number of pixels contained within the range of the designated CT numbers is liable to produce errors for the determination of the subarachnoid spaces and the ventricles with calcified colloid plexus. Therefore, for the present study was the method adopted, in which the subarachnoid spaces and the ventricles are measured based on the number of pixels contained in the region of interest by tracing them on the display monitor. Then, both Subarachnoid Space Volume Index (SVI) and Ventricle Volume Index (VVI) were calculated as the indices for cortical atrophy and ventricular dilatation in a slice through the level of the foramen interventriculare Monroi and other three successive ones through upper regions. Cerebral atrophy observed on CT in Alzheimer patients is attributable to Alzheimer's disease processes, rather than to physiological aging of the brain. The degree of the atrophy increases in proportion to the clinical stage, and cortical atrophy is apparent even at Stage I, whereas ventricular dilatation becomes pronounced at later stage. CT is one of effective clinical tests for the diagnosis of Alzheimer's disease.

  11. CT study in Alzheimer's disease

    Arai, Heii; Kobayashi, Kazunari; Ikeda, Kenji; Nagao, Yoshiko; Ogihara, Ryuji; Kosaka, Kenji

    1983-01-01

    Cerebral atrophy on CT was studied in 18 patients with clinically diagnosed Alzheimer's disease and in 14 healthy age-matched subjects as the control. The patients with Alzheimer's disease were divided into three groups of Stages I, Ii and III, according to their clinical symptoms. The study of the measurement method disclosed that the computerized measurement involving calculation of the number of pixels contained within the range of the designated CT numbers is liable to produce errors for the determination of the subarachnoid spaces and the ventricles with calcified colloid plexus. Therefor, for the present study was the method adopted, in which the subarachnoid spaces and the ventricles are measured based on the number of pixels contained in the region of interest by tracing them on the display monitor. Then, both Subarachnoid Space Volume Index (SVI) and Ventricle Volume Index (VVI) were calculated as the indices for cortical atrophy and ventricular dilatation in a slice through the level of the foramen interventriculare Monroi and other three successive ones through upper regions. Cerebral atrophy observed on CT in Alzheimer patients is attributable to Alzheimer's disease processes, rather than to physiological aging of the brain. The degree of the atrophy increases in proportion to the clinical stage, and cortical atrophy is apparent even at Stage I, whereas ventricular dilatation becomes pronounced at later stage. CT is one of effective clinical tests for the diagnosis of Alzheimer's disease. (J.P.N.)

  12. Epidemiology and the control of disease in China, with emphasis on the Chinese Biobank Study.

    Li, L; Guo, Y; Chen, Z; Chen, J; Peto, R

    2012-03-01

    Similar to many other developing countries, China is facing a double burden of disease as a result of epidemiological transition. Non-communicable diseases (NCDs) represent a major challenge, having an adverse effect on the health of the Chinese population and increasing the economic burden of health care. In today's era of evidence-based medicine and decision making, China, as a developing country, has a lack of local scientific evidence which will affect the effectiveness of NCD prevention and control. As such, and on the basis of decades of cooperation and trust with the University of Oxford, the Chinese Biobank Study [Kadoorie Study of Chronic Disease in China (KSCDC)] was commenced in 2004. KSCDC, an international prospective project, aims to establish the basis of a blood-based health database, using genetic, environmental and lifestyle aspects to investigate and understand the causes, risk factors, pathogenesis, prevalence patterns and trends of major chronic diseases in China (such as stroke, coronary heart disease, cancer, diabetes, hypertension, chronic obstructive pulmonary disease etc.). This study has a duration of 15-20 years, and will provide scientific evidence for strategic planning of NCD prevention and control, and development of new treatment and intervention approaches. In total, approximately 510,000 adults aged 30-79 years have been recruited from the general population in 10 geographically defined regions (five rural and five urban) of China, with differing disease profiles and differing risk exposures. Extensive data collection has been undertaken with questionnaires, physical measurements, and collection and storage of blood samples. KSCDC is a multi-factor, multi-disease, multi-disciplinary large-scale chronic disease epidemiological study, and is also one of the largest long-term blood-based population cohort studies ever conducted in the world. It is worth mentioning that all gene specimens are kept in China, and all associated

  13. Balancing Act: A Study of International School Heads' Efforts to Manage the Professional and Personal Aspects of Their Lives

    Sorenson, Christiane PJ

    2010-01-01

    Interest in the topic of professional and personal life balance has increased exponentially over the past several decades. The topic even is listed by the current First Lady of the United States as a priority item to be addressed during her husband's first four years in office. While studies have been conducted about the professional/personal…

  14. Milk production and distribution in low-dose counties for the Hanford Thyroid Disease Study

    Schimmel, J.G.

    1992-06-01

    This report identifies sources of milk consumed by residents of Ferry, Okanogan, and Stevens Counties. This information will be used by the Hanford thyroid Disease Study to determine whether thyroid disease has been increased among people exposed to past iodine--131 emissions from Hanford Site Facilities

  15. Changing incidence of diverticular disease of the colon in the Koreans: a radiological study

    Chung, Soo Kyo; Sohn, Hyung Sun; Lee, Soon Kyu; Bahk, Young Whee

    1979-01-01

    Diverticular disease of the colon is the commonest pathological process in the large bowel in the aged caucasians, but this is rare in oriental races.In Korea, diverticular disease of the colon was known to be rare as reported by Kim in 1964. Since then, however, we have had an impression that the diverticular disease of the colon is not so rare as was reported by Kim previously from our department. The present study has been undertaken to substantiate our impression. We received 1,143 consecutive cases of double-contrast barium performed at the Department of radiology, St. Mary's Hospital, Catholic Medical College during the past 7 years to analyzed diverticular disease patterns of the colon in the Koreans. 1. The present study revealed 29 patients of diverticular disease of the colon, an incidence of 2.5%. The age distribution was shown in Table 1. 2. The mean number of diverticular were 9 and the mean size as follows: the cecum, 6.4 mm; the proximal 1/3 of the ascending colon, 5.6 mm, The mid 1/3 of ascending colon, 4.9 mm; and the distal 1/3 of the ascending colon, 4.4 mm. 3. The average age of patients with diverticular disease of the colon was 49.5 years. Chief complaints were change of bowel habit (31.6%), abdominal pain (28.9%) and indigestion (18.4%). 4. The associated radiological findings of diverticular disease of the colon were: (1) spasm in 16 cases (46%); (2) a marginal irregularity in 16 cases (25%); and (3) asymmetrical haustra in 16 cases (30%). In 13 cases no associated signs seen. We have found that incidence of the diverticular disease of the colon in the present series is very significantly higher than that of the previous report from our department (Kim, 1964). We postulate that the possible factors operational in such increase in the incidence of the clonic diverticular disease in the last decade are: (1) changing dietary pattern characterized by high-protein and high refined-sugar consumption, and (2) routine use of the double contrast

  16. Changing incidence of diverticular disease of the colon in the Koreans: a radiological study

    Chung, Soo Kyo; Sohn, Hyung Sun; Lee, Soon Kyu; Bahk, Young Whee [St. Mary' s Hospital., Catholic Medical College, Seoul (Korea, Republic of)

    1979-06-15

    Diverticular disease of the colon is the commonest pathological process in the large bowel in the aged caucasians, but this is rare in oriental races.In Korea, diverticular disease of the colon was known to be rare as reported by Kim in 1964. Since then, however, we have had an impression that the diverticular disease of the colon is not so rare as was reported by Kim previously from our department. The present study has been undertaken to substantiate our impression. We received 1,143 consecutive cases of double-contrast barium performed at the Department of radiology, St. Mary's Hospital, Catholic Medical College during the past 7 years to analyzed diverticular disease patterns of the colon in the Koreans. 1. The present study revealed 29 patients of diverticular disease of the colon, an incidence of 2.5%. The age distribution was shown in Table 1. 2. The mean number of diverticular were 9 and the mean size as follows: the cecum, 6.4 mm; the proximal 1/3 of the ascending colon, 5.6 mm, The mid 1/3 of ascending colon, 4.9 mm; and the distal 1/3 of the ascending colon, 4.4 mm. 3. The average age of patients with diverticular disease of the colon was 49.5 years. Chief complaints were change of bowel habit (31.6%), abdominal pain (28.9%) and indigestion (18.4%). 4. The associated radiological findings of diverticular disease of the colon were: (1) spasm in 16 cases (46%); (2) a marginal irregularity in 16 cases (25%); and (3) asymmetrical haustra in 16 cases (30%). In 13 cases no associated signs seen. We have found that incidence of the diverticular disease of the colon in the present series is very significantly higher than that of the previous report from our department (Kim, 1964). We postulate that the possible factors operational in such increase in the incidence of the clonic diverticular disease in the last decade are: (1) changing dietary pattern characterized by high-protein and high refined-sugar consumption, and (2) routine use of the double contrast

  17. Statistical studies on heart disease of the pathological autopsy cases in the Atomic Bomb Hospital

    Matushita, H [Hiroshima Red Cross Hospital (Japan); Hamada, T; Ishida, S

    1976-03-01

    Of 1230 autopsied cases in the Atomic Bomb Hospital and in the Red-Cross Hospital from 1956 to March, 1975, a statistical study was made on 118 cases in which primary or secondary heart disease had been found. The results are as follows. The incidence of myocardial infarction was 2.4 times higher in the group exposed to the atomic bomb within 2 km distance from the bombed area than that it was in the unexposed group. The incidence of acquired valvular disease was 4.1 times higher in the exposed group than in the unexposed group. From the standpoint of the incidence of myocardiosis, there was no difference between the groups. The incidence of pericarditis was 1.5 times higher in the exposed group than in the unexposed group. The incidence of cor pulmonale was 1.8 times higher in the exposed group than in the unexposed group. The incidence of other heart disease including congenital disease was, however, 1.6 times higher in the unexposed group than in the exposed group. The incidence of general heart disease was 1.7 times higher in the exposed group than in the unexposed group. The incidence of hypertrophy of the heart (more than 400 g) was 1.2 times higher in the exposed group than in the unexposed group.

  18. Statistical studies on heart disease of the pathological autopsy cases in the Atomic Bomb Hospital

    Matushita, Hiroshi; Hamada, Tadao; Ishida, Sadamu.

    1976-01-01

    Of 1230 autopsied cases in the Atomic Bomb Hospital and in the Red-Cross Hospital from 1956 to March, 1975, a statistical study was made on 118 cases in which primary or secondary heart disease had been found. The results are as follows. The incidence of myocardial infarction was 2.4 times higher in the group exposed to the atomic bomb within 2 km distance from the bombed area than that it was in the unexposed group. The incidence of acquired valvular disease was 4.1 times higher in the exposed group than in the unexposed group. From the standpoint of the incidence of myocardiosis, there was no difference between the groups. The incidence of pericarditis was 1.5 times higher in the exposed group than in the unexposed group. The incidence of cor pulmonale was 1.8 times higher in the exposed group than in the unexposed group. The incidence of other heart disease including congenital disease was, however, 1.6 times higher in the unexposed group than in the exposed group. The incidence of general heart disease was 1.7 times higher in the exposed group than in the unexposed group. The incidence of hypertrophy of the heart (more than 400 g) was 1.2 times higher in the exposed group than in the unexposed group. (Namekawa, K.)

  19. Studies on the effects of ionizing radiation on the normal and diseased liver in experimental animals

    Mahmoud, S.A.

    1981-01-01

    The experiments carried out in the present study primarily concerned with the effects of ionizing radiations on the normal and diseased liver in experimental animals (mice). Different radiation intensities and different exposure schemes were used to irradiate both healthy and schistosoma mansoni infected animals. A group of uninfected and unirradiated animals were used as controls. Follow up studies were performed every 6 weeks for 30 weeks. These included histopathological studies of the liver damage at every observation periods for all animal groups

  20. Kidney Measures with Diabetes and Hypertension on Cardiovascular Disease : The Atherosclerosis Risk in Communities Study

    Alexander, Nadine; Matsushita, Kunihiro; Sang, Yingying; Ballew, Shoshana; Mahmoodi, Bakhtawar K.; Astor, Brad C.; Coresh, Josef

    2015-01-01

    Background: Whether the association of chronic kidney disease (CKD) with cardiovascular risk differs based on diabetes mellitus (DM) and hypertension (HTN) status remains unanswered. Methods: We investigated 11,050 participants from the Atherosclerosis Risk in Communities Study (fourth examination

  1. Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study

    Silkoff, P E; Strambu, I; Laviolette, M

    2015-01-01

    BACKGROUND: Asthma is a heterogeneous disease and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. The purpose of the ADEPT study was to correlate clinical features and biomarkers with molecular characteristics, by profiling asthma (NCT01274507). This re...

  2. The chick eye in vision research: An excellent model for the study of ocular disease.

    Wisely, C Ellis; Sayed, Javed A; Tamez, Heather; Zelinka, Chris; Abdel-Rahman, Mohamed H; Fischer, Andy J; Cebulla, Colleen M

    2017-11-01

    The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide range of ocular diseases and conditions. The purpose of this manuscript is to outline some anatomic, physiologic, and genetic features of this organism as a robust animal model for vision research, particularly for modeling human retinal disease. Advantages include a sequenced genome, a large eye, relative ease of handling and maintenance, and ready availability. Relevant similarities and differences to humans are highlighted for ocular structures as well as for general physiologic processes. Current research applications for various ocular diseases and conditions, including ocular imaging with spectral domain optical coherence tomography, are discussed. Several genetic and non-genetic ocular disease models are outlined, including for pathologic myopia, keratoconus, glaucoma, retinal detachment, retinal degeneration, ocular albinism, and ocular tumors. Finally, the use of stem cell technology to study the repair of damaged tissues in the chick eye is discussed. Overall, the chick model provides opportunities for high-throughput translational studies to more effectively prevent or treat blinding ocular diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease

    Da-Hye Jeon

    2017-11-01

    Full Text Available Objectives Dry eye disease (DED is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI. Methods The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015. This group included data from 752 participants, and data from 740 participants (253 men and 487 women were analyzed in the present study. DED severity was evaluated using the OSDI. Results Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011 and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010. In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051, while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027. In these analyses, we found no significant associations. Conclusions The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.

  4. The study on risk factor of metabolic diseases in pancreatic steatosis

    Cho, Jin Young; Ye, Soo Young; Kim, Dong Hyun [Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan, Busan (Korea, Republic of)

    2016-03-15

    The body of the fat tissue increased in obese represented by risk factors such as cardiovascular diseases, diabetes, metabolic disease and dyslipidemia. Such metabolic diseases and the like of the cardiovascular and cerebrovascular disease, hypertension, dyslipidemia, increase in the adipose tissue of the pancreas is known to be a risk factor of these diseases. Study on the diagnosis and treatment of pancreatic cancer was conducted actively, case studies on pancreatic steatosis is not much. In this study, divided into a control group diagnosed with pancreatic steatosis as a result of ultrasonography to evaluation the physical characteristics and serologic tests and blood pressure and arterial stiffness. The control group and the test pancreas steatosis age and waist circumference, body mass index, total cholesterol, HDL cholesterol, LDL cholesterol, and systolic and diastolic blood pressure, fasting blood glucose, arterial elasticity is higher in pancreatic steatosis. And the lower ankle brachial stenosis and HDLcholesterol were lower than the normal control group, so the pancreatic steatosis harmful to blood vessels.(P <0.05). The difference between the control group and it was confirmed that the pancreatic jibanggun statistically significant. In conclusion, pancreatic steatosis at abdominal ultrasound can predict the risk of metabolic diseases, and there was a correlation with cardiovascular disease.

  5. The study on risk factor of metabolic diseases in pancreatic steatosis

    Cho, Jin Young; Ye, Soo Young; Kim, Dong Hyun

    2016-01-01

    The body of the fat tissue increased in obese represented by risk factors such as cardiovascular diseases, diabetes, metabolic disease and dyslipidemia. Such metabolic diseases and the like of the cardiovascular and cerebrovascular disease, hypertension, dyslipidemia, increase in the adipose tissue of the pancreas is known to be a risk factor of these diseases. Study on the diagnosis and treatment of pancreatic cancer was conducted actively, case studies on pancreatic steatosis is not much. In this study, divided into a control group diagnosed with pancreatic steatosis as a result of ultrasonography to evaluation the physical characteristics and serologic tests and blood pressure and arterial stiffness. The control group and the test pancreas steatosis age and waist circumference, body mass index, total cholesterol, HDL cholesterol, LDL cholesterol, and systolic and diastolic blood pressure, fasting blood glucose, arterial elasticity is higher in pancreatic steatosis. And the lower ankle brachial stenosis and HDLcholesterol were lower than the normal control group, so the pancreatic steatosis harmful to blood vessels.(P <0.05). The difference between the control group and it was confirmed that the pancreatic jibanggun statistically significant. In conclusion, pancreatic steatosis at abdominal ultrasound can predict the risk of metabolic diseases, and there was a correlation with cardiovascular disease

  6. The impact of dietary risk factors on the burden of non-communicable diseases in Ethiopia : findings from the Global Burden of Disease study 2013

    Melaku, Yohannes Adama; Temesgen, Awoke Misganaw; Deribew, Amare; Tessema, Gizachew Assefa; Deribe, Kebede; Sahle, Berhe W.; Abera, Semaw Ferede; Bekele, Tolesa; Lemma, Ferew; Amare, Azmeraw T.; Seid, Oumer; Endris, Kedir; Hiruye, Abiy; Worku, Amare; Adams, Robert; Taylor, Anne W.; Gill, Tiffany K.; Shi, Zumin; Afshin, Ashkan; Forouzanfar, Mohammad H.

    2016-01-01

    Background: The burden of non-communicable diseases (NCDs) has increased in sub-Saharan countries, including Ethiopia. The contribution of dietary behaviours to the NCD burden in Ethiopia has not been evaluated. This study, therefore, aimed to assess diet-related burden of disease in Ethiopia

  7. Vitreous cinematography in the study of vitreoretinal diseases.

    Trempe, C L; Takahashi, M; Freeman, H M

    1981-07-01

    A new technique of vitreous cinematography involves scanning of the vitreous cavity using optical sections to provide objective, reproducible information on the dynamics of the posterior vitreous and vitreoretinal relationships. Using a newly developed preset lens (El Bayadi-Kajiura lens), this technique makes it possible to document an entire optical section of the posterior vitreous. This is done by mechanically displacing the vitreous so that maximum reflectivity can be obtained from the vitreous gel. This article describes the technique and presents clinical examples documenting complete and incomplete vitreous detachment in normal eyes, Cloquet's canal associated with an optic disc pit, vitreous traction associated with a lamellar hole in an area of preretinal macular fibrosis, and vitreous traction at the anterior flap of a retinal break.

  8. LADY GAGA: UNINDO MODA, MÚSICA POP E ARTE

    Letícia Guedes de Paula

    2017-03-01

    Full Text Available O trabalho em questão insere-se no contexto de uma pesquisa mais ampla a respeito da relação entre Moda e Arte. Analisam-se aspectos da obra da artista pop Lady Gaga, que desenvolve seus trabalhos multifacetados sob uma perspectiva segundo a qual Moda e Música são dimensões da Arte Pop. A proposta de Lady Gaga é influenciada por Andy Warhol e transparece não apenas em suas produções artísticas, como também em suas declarações à imprensa, objeto de análise deste estudo. Gaga busca o status de Arte para seus trabalhos, independentemente do aspecto comercial que estes possam apresentar. Sua proposta, que pode ser resumida na afirmação “o que é feito com Arte permanece”, pode ser aplicada indistintamente a qualquer dos aspectos de sua obra, Música e Moda incluídas.

  9. Transgenic mice expressing human glucocerebrosidase variants: utility for the study of Gaucher disease.

    Sanders, Angela; Hemmelgarn, Harmony; Melrose, Heather L; Hein, Leanne; Fuller, Maria; Clarke, Lorne A

    2013-08-01

    Gaucher disease is an autosomal recessively inherited storage disorder caused by deficiency of the lysosomal hydrolase, acid β-glucosidase. The disease manifestations seen in Gaucher patients are highly heterogeneous as is the responsiveness to therapy. The elucidation of the precise factors responsible for this heterogeneity has been challenging as the development of clinically relevant animal models of Gaucher disease has been problematic. Although numerous murine models for Gaucher disease have been described each has limitations in their specific utility. We describe here, transgenic murine models of Gaucher disease that will be particularly useful for the study of pharmacological chaperones. We have produced stable transgenic mouse strains that individually express wild type, N370S and L444P containing human acid β-glucosidase and show that each of these transgenic lines rescues the lethal phenotype characteristic of acid β-glucosidase null mice. Both the N370S and L444P transgenic models show early and progressive elevations of tissue sphingolipids with L444P mice developing progressive splenic Gaucher cell infiltration. We demonstrate the potential utility of these new transgenic models for the study of Gaucher disease pathogenesis. In addition, since these mice produce only human enzyme, they are particularly relevant for the study of pharmacological chaperones that are specifically targeted to human acid β-glucosidase and the common mutations underlying Gaucher disease. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Value of the radiological study of the thorax for diagnosing left ventricular dysfunction in Chagas' disease

    Perez Amanda Arantes

    2003-01-01

    Full Text Available OBJECTIVE: To determine the value of the radiological study of the thorax for diagnosing left ventricular dilation and left ventricular systolic dysfunction in patients with Chagas' disease. METHODS: A cross-sectional study of 166 consecutive patients with Chagas' disease and no other associated diseases. The patients underwent cardiac assessment with chest radiography and Doppler echocardiography. Sensitivity, specificity, and positive and negative predictive values of chest radiography were calculated to detect left ventricular dysfunction and the accuracy of the cardiothoracic ratio in the diagnosis of left ventricular dysfunction with the area below the ROC curve. The cardiothoracic ratio was correlated with the left ventricular ejection fraction and the left ventricular diastolic diameter. RESULTS: The abnormal chest radiogram had a sensitivity of 50%, specificity of 80.5%, and positive and negative predictive values of 51.2% and 79.8%, respectively, in the diagnosis of left ventricular dysfunction. The cardiothoracic ratio showed a weak correlation with left ventricular ejection fraction (r=-0.23 and left ventricular diastolic diameter (r=0.30. The area calculated under the ROC curve was 0.734. CONCLUSION: The radiological study of the thorax is not an accurate indicator of left ventricular dysfunction; its use as a screening method to initially approach the patient with Chagas' disease should be reevaluated.

  11. The integrated disease network.

    Sun, Kai; Buchan, Natalie; Larminie, Chris; Pržulj, Nataša

    2014-11-01

    The growing body of transcriptomic, proteomic, metabolomic and genomic data generated from disease states provides a great opportunity to improve our current understanding of the molecular mechanisms driving diseases and shared between diseases. The use of both clinical and molecular phenotypes will lead to better disease understanding and classification. In this study, we set out to gain novel insights into diseases and their relationships by utilising knowledge gained from system-level molecular data. We integrated different types of biological data including genome-wide association studies data, disease-chemical associations, biological pathways and Gene Ontology annotations into an Integrated Disease Network (IDN), a heterogeneous network where nodes are bio-entities and edges between nodes represent their associations. We also introduced a novel disease similarity measure to infer disease-disease associations from the IDN. Our predicted associations were systemically evaluated against the Medical Subject Heading classification and a statistical measure of disease co-occurrence in PubMed. The strong correlation between our predictions and co-occurrence associations indicated the ability of our approach to recover known disease associations. Furthermore, we presented a case study of Crohn's disease. We demonstrated that our approach not only identified well-established connections between Crohn's disease and other diseases, but also revealed new, interesting connections consistent with emerging literature. Our approach also enabled ready access to the knowledge supporting these new connections, making this a powerful approach for exploring connections between diseases.

  12. Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana.

    Ephraim, Richard Kobina Dadzie; Osakunor, Derick Nii Mensah; Cudjoe, Obed; Oduro, Enos Amoako; Asante-Asamani, Lyudmila; Mitchell, Juliana; Agbodzakey, Hope; Adoba, Prince

    2015-05-29

    Renal involvement in sickle cell disease (SCD) contributes significantly to morbidity and mortality. The aim of this study was to determine the prevalence of chronic kidney disease (CKD) amongst SCD patients, and how basic clinical variables differ across haemoglobin genotypes. A hospital-based cross-sectional study conducted from December 2013 to May 2014 at the Sickle cell clinic of the Tema General Hospital. One hundred and ninety-four (194) participants with SCD, receiving medical care at the outpatient sickle cell clinic were enrolled onto the study. A structured questionnaire was administered to obtain information on demography, clinical history, blood pressure and anthropometry. Blood and urine samples were taken for serum creatinine and proteinuria determination respectively. The estimated GFR (eGFR) was calculated using the CKD-EPI and Schwartz equations. CKD was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Analysis was performed using GraphPad prism and P <0.05 was considered statistically significant. CKD was present in 39.2% of participants. Using KDIGO guidelines, 40.8% of the HbSS participants had stage 1 CKD and none had stage 2 CKD. In addition, 30.8% of the HbSC participants had stage 1 CKD and 3.8% had stage 2 CKD. There was a trend of increasing age across CKD stages and stage 2 CKD participants were oldest (P < 0.001). Results from the current study suggest that CKD is common amongst SCD patients and prevalence and intensity increases with age. Proteinuria and CKD was more common in HbSS genotype than in HbSC genotype.

  13. Quantifying the contributions of behavioral and biological risk factors to socioeconomic disparities in coronary heart disease incidence: the MORGEN study

    Kershaw, Kiarri N.; Droomers, Mariël; Robinson, Whitney R.; Carnethon, Mercedes R.; Daviglus, Martha L.; Verschuren, W. M. Monique

    2013-01-01

    Quantifying the impact of different modifiable behavioral and biological risk factors on socioeconomic disparities in coronary heart disease (CHD) may help inform targeted, population-specific strategies to reduce the unequal distribution of the disease. Previous studies have used analytic

  14. Parkinson's disease: Studies on the pathology of the disease and the mechanism of action of the neurotoxin MPTP

    D'Amato, R.J.

    1988-01-01

    In humans and animals, exposure to 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) causes certain clinical, pathological, and neurochemical features of Parkinson's disease (PD). MPTP is metabolized in the brain by monoamine oxidase (MAOb) to 1-methyl-4-phenylpyridine (MPP + ), which is selectively accumulated and concentrated by high affinity uptake mechanisms into catecholamine neurons. We have demonstrated high affinity binding of MPP + to neuromelanin which may result in a toxic intraneuronal sequestration of MPP + . The involvement of neuromelanin is further supported by the demonstration that monkeys pretreated with chloroquine prior to the administration of MPTP are protected from MPTP induced neurotoxicity. Decreases in serotonin levels have been reported in the brains and spinal fluid of patients with both Parkinson's and Alzheimer's disease. In an effort to investigate the pathology of serotonin neurons in postmortem brain tissue from Parkinson's and Alzheimer's patients, [ 3 H]citalopram was characterized as a means of labeling serotonin uptake sites present on serotonin terminals

  15. Establishing a Consortium for the Study of Rare Diseases: The Urea Cycle Disorders Consortium

    Seminara, Jennifer; Tuchman, Mendel; Krivitzky, Lauren; Krischer, Jeffrey; Lee, Hye-Seung; LeMons, Cynthia; Baumgartner, Matthias; Cederbaum, Stephen; Diaz, George A.; Feigenbaum, Annette; Gallagher, Renata C.; Harding, Cary O.; Kerr, Douglas S.; Lanpher, Brendan; Lee, Brendan; Lichter-Konecki, Uta; McCandless, Shawn E.; Merritt, J. Lawrence; Oster-Granite, Mary Lou; Seashore, Margretta R.; Stricker, Tamar; Summar, Marshall; Waisbren, Susan; Yudkoff, Marc; Batshaw, Mark L.

    2010-01-01

    The Urea Cycle Disorders Consortium (UCDC) was created as part of a larger network established by the National Institutes of Health to study rare diseases. This paper reviews the UCDC’s accomplishments over the first six years, including how the Consortium was developed and organized, clinical research studies initiated, and the importance of creating partnerships with patient advocacy groups, philanthropic foundations and biotech and pharmaceutical companies. PMID:20188616

  16. Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM Study Design: Approach to the Future of Personalized Prevention of Celiac Disease

    Maureen M. Leonard

    2015-11-01

    Full Text Available In the past it was believed that genetic predisposition and exposure to gluten were necessary and sufficient to develop celiac disease (CD. Recent studies however suggest that loss of gluten tolerance can occur at any time in life as a consequence of other environmental stimuli. Many environmental factors known to influence the composition of the intestinal microbiota are also suggested to play a role in the development of CD. These include birthing delivery mode, infant feeding, and antibiotic use. To date no large-scale longitudinal studies have defined if and how gut microbiota composition and metabolomic profiles may influence the loss of gluten tolerance and subsequent onset of CD in genetically-susceptible individuals. Here we describe a prospective, multicenter, longitudinal study of infants at risk for CD which will employ a blend of basic and applied studies to yield fundamental insights into the role of the gut microbiome as an additional factor that may play a key role in early steps involved in the onset of autoimmune disease.

  17. The Dutch gas policy: 'Dutch disease' or imaginary disease. CERI Studies Nr 11

    Crowley, John

    1998-04-01

    The Netherlands are the first European gas producer and exporter. The author proposes an analysis of the gas policy of this country. He first recalls some elements of context: peculiarities of energy as a domain of public policy, and characteristics of the Dutch political system. He recalls the historical development of the Dutch gas industry from the 1960's: political economics of natural gas and of competing fuels, development of the Groningen site as the keystone of the Dutch gas policy, and regulation of the industrial sector. In the next part, the author comments the emergence of energy as a topic of public debate from 1995, and how the Dutch gas policy has been put into question again: actors and interaction dynamics, stakes, present policy and perspectives

  18. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013

    J.D. Stanaway (Jeffrey D.); D.S. Shepard (Donald); E.A. Undurraga (Eduardo); Halasa, Y.A. (Yara A); L.E. Coffeng (Luc); Brady, O.J. (Oliver J); Hay, S.I. (Simon I); Bedi, N. (Neeraj); I.M. Bensenor (Isabela M.); C.A. Castañeda-Orjuela (Carlos A); T.-W. Chuang (Ting-Wu); K.B. Gibney (Katherine B); Z.A. Memish (Ziad); A. Rafay (Anwar); K.N. Ukwaja (Kingsley N); N. Yonemoto (Naohiro); C.J.L. Murray (Christopher)

    2016-01-01

    textabstractBackground Dengue is the most common arbovirus infection globally, but its burden is poorly quantified. We estimated dengue mortality, incidence, and burden for the Global Burden of Disease Study 2013. Methods We modelled mortality from vital registration, verbal autopsy, and

  19. Leading ladies: women in healthcare leadership.

    Fontenot, Teri

    2012-01-01

    Women represent an overwhelming majority of the healthcare workforce, yet they are significantly underrepresented in leadership positions, particularly at the executive and board levels. However, women are uniquely positioned to leverage traits such as compassion, transparency, and the ability to foster teamwork to lead organizations into the next phase of contemporary healthcare delivery. In the future, the pace with which women gain access to the C-suite will accelerate as organizations embrace diversity and select the best qualified leaders in terms of both experience and leadership style that supports organizational culture. While the future for women in healthcare leadership looks bright, many women are currently struggling to reach the executive office, facing glass ceilings, competing priorities, and lack of access to support and guidance. In this article I discuss the role of women in healthcare leadership and offer practical suggestions on how women can reach the top echelon and achieve their goals and aspirations.

  20. Radioisotopic studies of bone diseases

    Ell, P.J.

    1976-01-01

    Consideration is given to the study of bone diseases. The most used radionuclides in the skeletal investigation are analysed and a table of radiopharmaceuticals of localization in the skeleton is showed. Emphasis is given to the use of Strontium 85 and 87m, fluorine 18 and technetium 99m. The phosphate compounds labelled with Technetium 99m are studied in detail and the structures of these organic and inorganic compounds are given. A table with values of the blood clearance of those compounds is presented. The skeletal distribution of the phosphate compounds-sup(99m)Tc, as well as the abnormal scintigraphy of skeleton by means of them, are analysed. Referring to bone diseases, the benign and malignant ones are studied: a table is given of bone diseases with positive imaging to the skeleton scintigraphy in the former case and the main applications of this scintigraphy in the latter one. Emphasis is given, in all the cases, to the clinical applications of the method, with recommendations in each one. Scintigraphic imagings are presented referring to each item studied [pt

  1. Lady Academe and Labor-Market Segmentation

    Bousquet, Marc

    2012-01-01

    The role of gender in the global economy is not represented particularly well by old-school "pipeline" theories of women entering particular industries, whether it is manufacturing, medicine, or college teaching. The pipeline analogy suggests that if women enter a field in equal or greater numbers to men, they will somehow automatically be "piped"…

  2. A study of the cerebral blood flow pattern and cognitive deficit in Parkinson's disease

    Tamaru, Fuyuhiko

    1997-01-01

    Cerebral blood flow pattern in Parkinson's disease was examined by 123 I-IMP SPECT to determine whether the deficit in cognitive function is reflected in it. The patient group with Parkinson's disease showed deterioration in intelligence (Minimental state examination, Raven's Colored Progressive Matrices) and frontal lobe test (the Wisconsin Card Sorting Test). Though the uptake ratio of prefrontal area/occipital area in 123 I-IMP SPECT study varied widely in the Parkinson's disease group compared to the normal control group, there was no significant difference in the mean. Selective depletion of frontal lobe blood flow was not confirmed in this study. There was no correlation between cerebral blood flow pattern and cognitive functions including frontal lobe function and intelligence. We concluded that the deficit in cognitive function was not reflected in the cerebral blood flow pattern in Parkinson's disease. (author)

  3. The effect of long working hours on cerebrovascular and cardiovascular disease; A case-crossover study.

    Shin, Kyong-Sok; Chung, Yun Kyung; Kwon, Young-Jun; Son, Jun-Seok; Lee, Se-Hoon

    2017-09-01

    This study investigated the relationship between weekly working hours and the occurrence of cerebro-cardiovascular diseases using a case-crossover study design. We investigated average working hours during the 7 days before the onset of illness (hazard period) and average weekly working hours between 8 days and 3 months before the onset of cerebro-cardiovascular diseases (control period) for 1,042 cases from the workers' compensation database for 2009. Among all subjects, the odds ratio by conditional logistic regression for the risk of cerebro-cardiovascular diseases with a 10 hr increase in average weekly working hours was 1.45 (95% confidence interval [CI]: 1.22-1.72), a significant association. An increase in average weekly working hours may trigger the onset of cerebro-cardiovascular disease. Am. J. Ind. Med. 60:753-761, 2017. © 2017. Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  4. Clinical Factors and Disease Course Related to Diagnostic Delay in Korean Crohn's Disease Patients: Results from the CONNECT Study.

    Chang Mo Moon

    Full Text Available Diagnostic delay frequently occurs in Crohn's disease (CD patients because of diagnostic limitations. However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD patient cohort. We performed a multicenter retrospective analysis of 1,047 CD patients registered in the Crohn's Disease Clinical Network and Cohort study in Korea. The mean interval of diagnostic delay was 16.0 ± 33.1 months. Multivariate analysis showed that older age at diagnosis (≥40 years (p = 0.014, concomitant upper gastrointestinal (UGI disease (p = 0.012 and penetrating disease behavior at diagnosis (p = 0.001 were positively associated with long diagnostic delay (≥18 months. During the longitudinal follow-up, long diagnostic delay was independently predictive of further development of intestinal stenosis (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.07-1.93; p = 0.017, internal fistulas (HR, 1.62; 95% CI, 1.12-2.33; p = 0.011, and perianal fistulas (HR, 1.38; 95% CI, 1.06-1.80; p = 0.016. However, as for the risk of abscess formation, bowel perforation, and CD-related abdominal surgery, no significant association with diagnostic delay was observed. Older age at diagnosis, UGI involvement, and penetrating behavior are associated with long diagnostic delay in Korean CD patients. Moreover, diagnostic delay is associated with an increased risk of CD-related complications such as intestinal stenosis, internal fistulas, and perianal fistulas.

  5. Lady with Erotic Preference for Diapers.

    Cernovsky, Zack; Bureau, Yves

    2016-11-23

    A patient in her 20s was referred to us for psychological assessment due to her depression and suicide attempts. She mentioned being anorgasmic except when diapered and emphasized her erotic preference for diapers. Her childhood included maternal deprivation in an impecunious family headed by an irritable physically disabled father on social assistance. Given the maternal deprivation in childhood, her erotic fixation on diapers parallels the emotional attachment to diapers observed by Harlow in mother deprived infant monkeys. Etiological hypotheses should also include the paradigm of avoidance learning from theories of behavior therapy. Our patient does not wish to change her sexual preference: in such cases, fetishism is not considered as an illness by DSM5. However, she needs to be treated for pathological levels of depression with suicidal ideation and low self-esteem.

  6. Lady with erotic preference for diapers

    Zack Cernovsky

    2016-11-01

    Full Text Available A patient in her 20s was referred to us for psychological assessment due to her depression and suicide attempts. She mentioned being anorgasmic except when diapered and emphasized her erotic preference for diapers. Her childhood included maternal deprivation in an impecunious family headed by an irritable physically disabled father on social assistance. Given the maternal deprivation in childhood, her erotic fixation on diapers parallels the emotional attachment to diapers observed by Harlow in mother deprived infant monkeys. Etiological hypotheses should also include the paradigm of avoidance learning from theories of behavior therapy. Our patient does not wish to change her sexual preference: in such cases, fetishism is not considered as an illness by DSM5. However, she needs to be treated for pathological levels of depression with suicidal ideation and low self-esteem.

  7. The Helicobacter pylori theory and duodenal ulcer disease. A case study of the research process

    Christensen, A H; Gjørup, T

    1995-01-01

    should be selected for H. pylori eradication treatment. CONCLUSION: Descriptive clinical studies and laboratory studies of disease mechanisms were the prevailing types of research about H. pylori. Comparatively few therapeutic intervention studies were done; this fact may have hampered the acceptance......OBJECTIVES: To describe the medical research process from the time of the generation of a new theory to its implementation in clinical practice. The Helicobacter pylori (H. pylori) theory, i.e. the theory that H. pylori plays a significant causal role in duodenal ulcer disease was chosen as a case....... MATERIAL: Abstracts from 1984 to 1993, identified in the CD-Rom, Medline system, ("Silverplatter"), using the search terms Campylobacter pylori and Helicobacter pylori, and reviews and editorials about H. pylori in some of the most widespread clinical journals. RESULTS: 2204 papers on H. pylori were...

  8. Cardiovascular comorbidity in patients with chronic obstructive pulmonary disease in the Canary Islands (CCECAN study).

    Figueira Gonçalves, Juan Marco; Dorta Sánchez, Rafael; Rodri Guez Pérez, María Del Cristo; Viña Manrique, Pedro; Díaz Pérez, David; Guzmán Saenz, Cristina; Palmero Tejera, Juan Manuel; Pérez Rodríguez, Alicia; Pérez Negrín, Lorenzo

    Numerous studies have shown a high prevalence of cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to analyse the prevalence of cardiovascular risk factors and comorbidity in a Canary Islands population diagnosed with COPD, and compared it with data from the general population. A cross-sectional study was carried out in 300 patients with COPD and 524 subjects without respiratory disease (control group). The two groups were compared using standard bivariate methods. Logistic regression models were used to estimate the cardiovascular risks in COPD patients compared to control group. Patients with COPD showed a high prevalence of hypertension (72%), dyslipidaemia (73%), obesity (41%), diabetes type 2 (39%), and sleep apnoea syndrome (30%) from mild stages of the disease (GOLD 2009). There was a 22% prevalence of cardiac arrhythmia, 16% of ischaemic heart disease, 16% heart failure, 12% peripheral vascular disease, and 8% cerebrovascular disease. Compared to the control group, patients with COPD had a higher risk of dyslipidaemia (OR 3.24, 95% CI; 2.21-4.75), diabetes type 2 (OR 1.52, 95% CI; 1.01-2,28), and ischaemic heart disease (OR 2.34, 95% CI; 1.22-4.49). In the case of dyslipidaemia, an increased risk was obtained when adjusted for age, gender, and consumption of tobacco (OR 5.04, 95% CI; 2.36-10.74). Patients with COPD resident in the Canary Islands have a high prevalence of hypertension, dyslipidaemia, ischaemic heart disease, and cardiac arrhythmia. Compared to general population, patients with COPD have a significant increase in the risk of dyslipidaemia. Copyright © 2017 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Brain and heart disease studies

    Budinger, T.F.; Sargent, T.W. III; Yen, C.K.; Friedland, R.F.; Moyer, B.R.

    1981-01-01

    Highlights of important studies completed during the past year using the Donner 280-crystal positron ring tomograph are summarized in this article. Using rubidium-82, images of a brain tumor and an arteriovenous malformation are described. An image demonstrating methionine uptake in a patient with schizophrenia and an image reflecting sugar metabolism in the brain of a man with Alzheimer's disease are also included. Uptake of rubidium-82 in subjects before and after exercise is being investigated. The synthesis of new radiopharmaceuticals and the development of a new synthesis for C-taurine for use in the study of metabolism in the human heart are also being studied

  10. Studying the role of dystrophin-associated proteins in influencing Becker muscular dystrophy disease severity.

    van den Bergen, J C; Wokke, B H A; Hulsker, M A; Verschuuren, J J G M; Aartsma-Rus, A M

    2015-03-01

    Becker muscular dystrophy is characterized by a variable disease course. Many factors have been implicated to contribute to this diversity, among which the expression of several components of the dystrophin associated glycoprotein complex. Together with dystrophin, most of these proteins anchor the muscle fiber cytoskeleton to the extracellular matrix, thus protecting the muscle from contraction induced injury, while nNOS is primarily involved in inducing vasodilation during muscle contraction, enabling adequate muscle oxygenation. In the current study, we investigated the role of three components of the dystrophin associated glycoprotein complex (beta-dystroglycan, gamma-sarcoglycan and nNOS) and the dystrophin homologue utrophin on disease severity in Becker patients. Strength measurements, data about disease course and fresh muscle biopsies of the anterior tibial muscle were obtained from 24 Becker patients aged 19 to 66. The designation of Becker muscular dystrophy in this study was based on the mutation and not on the clinical severity. Contrary to previous studies, we were unable to find a relationship between expression of nNOS, beta-dystroglycan and gamma-sarcoglycan at the sarcolemma and disease severity, as measured by muscle strength in five muscle groups and age at reaching several disease milestones. Unexpectedly, we found an inverse correlation between utrophin expression at the sarcolemma and age at reaching disease milestones. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Quantifying the benefits of achieving or maintaining long-term low risk profile for cardiovascular disease : The doetinchem cohort study

    Hulsegge, Gerben; Smit, Henriëtte A.; Van Der Schouw, Yvonne T.; Daviglus, Martha L.; Verschuren, W. M Monique

    2015-01-01

    Background: Studies investigating the relation between risk profiles and cardiovascular disease have measured risk at baseline only. We investigated maintenance and changes of risk profiles over time and their potential impact on incident cardiovascular disease. Design: Population-based cohort

  12. Quantifying the benefits of achieving or maintaining long-term low risk profile for cardiovascular disease: The Doetinchem Cohort Study

    Hulsegge, G.; Smit, H.A.; van der Schouw, Y.T.; Daviglus, M.L.; Verschuren, W.M.

    2015-01-01

    Background: Studies investigating the relation between risk profiles and cardiovascular disease have measured risk at baseline only. We investigated maintenance and changes of risk profiles over time and their potential impact on incident cardiovascular disease. Design: Population-based cohort

  13. Neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.

    Legendre, Claire-Marie; Charpentier-Côté, Catherine; Drouin, Régen; Bouffard, Chantal

    2011-02-09

    In 1986, two Canadian geneticists had demonstrated that Joseph Merrick, better known as the Elephant Man, suffered from the Proteus syndrome and not from neurofibromatosis type 1 (NF1), as was alleged by dermatologist Parkes in 1909. Despite this and although the two diseases differ at several levels: prevalence, diagnostic criteria, clinical manifestations and transmission, the confusion between NF1 and the "elephant man's" disease continues in medical and social representations by current linguistic usage, and in some media reports. With this article, we want to 1) document the persistence and extent of this fallacy, 2) identify certain critical factors that contribute to its persistence, and 3) evaluate its impact on the health and well being of patients with NF1 and their family members. Participant observation in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents - Analysis of the scientific literature and of pinpoint articles in the print and online news media. Our findings show that because physicians have little knowledge about NF1, several print and online news media and a lot of physicians continue to make the confusion between NF1 and the disease the "elephant man". This misconception contributes to misinformation about the disease, feeding prejudices against affected patients, exacerbating the negative impacts of the disease on their quality of life, their cognitive development, their reproductive choices, as well as depriving them of proper care and appropriate genetic counseling. If family physicians and pediatricians were properly informed about the disease, they could refer their patients with NF1 to NF clinics and to specialists. Thus, patients and their family members would benefit from better-tailored clinical management of their cases, perhaps even optimal management. [corrected

  14. Neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.

    Claire-Marie Legendre

    2011-02-01

    Full Text Available In 1986, two Canadian geneticists had demonstrated that Joseph Merrick, better known as the Elephant Man, suffered from the Proteus syndrome and not from neurofibromatosis type 1 (NF1, as was alleged by dermatologist Parkes in 1909. Despite this and although the two diseases differ at several levels: prevalence, diagnostic criteria, clinical manifestations and transmission, the confusion between NF1 and the "elephant man's" disease continues in medical and social representations by current linguistic usage, and in some media reports. With this article, we want to 1 document the persistence and extent of this fallacy, 2 identify certain critical factors that contribute to its persistence, and 3 evaluate its impact on the health and well being of patients with NF1 and their family members.Participant observation in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents - Analysis of the scientific literature and of pinpoint articles in the print and online news media.Our findings show that because physicians have little knowledge about NF1, several print and online news media and a lot of physicians continue to make the confusion between NF1 and the disease the "elephant man". This misconception contributes to misinformation about the disease, feeding prejudices against affected patients, exacerbating the negative impacts of the disease on their quality of life, their cognitive development, their reproductive choices, as well as depriving them of proper care and appropriate genetic counseling.If family physicians and pediatricians were properly informed about the disease, they could refer their patients with NF1 to NF clinics and to specialists. Thus, patients and their family members would benefit from better-tailored clinical management of their cases, perhaps even optimal management. [corrected

  15. Association Between Periodontal Disease and Kidney Function Decline in African Americans: The Jackson Heart Study.

    Grubbs, Vanessa; Vittinghoff, Eric; Beck, James D; Kshirsagar, Abhijit V; Wang, Wei; Griswold, Michael E; Powe, Neil R; Correa, Adolfo; Young, Bessie

    2015-10-01

    Chronic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects African Americans, despite intense efforts targeting traditional risk factors. Periodontal disease, a chronic bacterial infection of the oral cavity, is both common and modifiable and has been implicated as a novel potential CKD risk factor. The authors seek to examine to what extent periodontal disease is associated with kidney function decline. This retrospective cohort study examines 699 African American participants with preserved kidney function (defined by estimated glomerular filtration rate (eGFR) >60 mL/minute/1.73 m(2) at baseline) who underwent complete dental examinations as part of the Dental-Atherosclerosis Risk in Communities study (1996 to 1998) and subsequently enrolled in the Jackson Heart Study (2000 to 2004). Using multivariable Poisson regression, the authors examined the association of periodontal disease (severe versus non-severe) with incident CKD, defined as incident eGFR periodontal disease. There were 21 cases (3.0%) of incident CKD after a mean follow-up of 4.8 (± 0.6) years. Compared with participants with non-severe periodontal disease, those with severe periodontal disease had a four-fold greater rate of incident CKD (adjusted incidence rate ratio 4.18 [95% confidence interval 1.68 to 10.39], P = 0.002). Severe periodontal disease is prevalent among a population at high risk for CKD and is associated with clinically significant kidney function decline. Further research is needed to determine if periodontal disease treatment alters the trajectory of renal deterioration.

  16. The impact of global environmental change on vector-borne disease risk: a modelling study

    Rachel Lowe, PhD

    2018-05-01

    Full Text Available Background: Vector-borne diseases, such as dengue virus, Zika virus, and malaria, are highly sensitive to environmental changes, including variations in climate and land-surface characteristics. The emergence and spread of vector-borne diseases is also exacerbated by anthropogenic activities, such as deforestation, mining, urbanisation, and human mobility, which alter the natural habitats of vectors and increase vector–host interactions. Innovative epidemiological modelling tools can help to understand how environmental conditions interact with socioeconomic risk factors to predict the risk of disease transmission. In recent years, climate-health modelling has benefited from computational advances in fitting complex mathematical models; increasing availability of environmental, socioeconomic, and disease surveillance datasets; and improved ability to understand and model the climate system. Climate forecasts at seasonal time scales tend to improve in quality during El Niño-Southern Oscillation events in certain regions of the tropics. Thus, climate forecasts provide an opportunity to anticipate potential outbreaks of vector-borne diseases from several months to a year in advance. The aim of this study was to develop a framework to incorporate seasonal climate forecasts in predictive disease models to understand the future risk of vector-borne diseases, with a focus on dengue fever in Latin America. Methods: A Bayesian spatiotemporal model framework that quantifies the extent to which environmental and socioeconomic indicators can explain variations in disease risk was designed to disentangle the effects of climate from other risk factors using multi-source data and random effects, which account for unknown and unmeasured sources of spatial, seasonal, and inter-annual variation. The model was used to provide probabilistic predictions of monthly dengue incidence and the probability of exceeding outbreak thresholds, which were established in

  17. Natural history of severe atheromatous disease of the thoracic aorta: a transesophageal echocardiographic study.

    Montgomery, D H; Ververis, J J; McGorisk, G; Frohwein, S; Martin, R P; Taylor, W R

    1996-01-01

    This study sought to prospectively observe the morphologic and clinical natural history of severe atherosclerotic disease of the thoracic aorta as defined by transesophageal echocardiography. Atherosclerosis of the thoracic aorta has been shown to be highly associated with risk for embolic events in transesophageal studies, but the natural history of the disease under clinical conditions has not been reported. During a 20-month period, 191 of 264 patients undergoing transesophageal echocardiography had adequate visualization of the aorta to allow atherosclerotic severity to be graded as follows: grade I = normal (44 patients); grade II = intimal thickening (52 patients); grade III = atheroma or = 5 mm (19 patients); grade V = mobile lesion (14 patients). All available patients with grades IV (8 patients) and V (10 patients) disease as well as a subgroup of 12 patients with grade III disease had follow-up transesophageal echocardiographic studies (mean [+/- SD] 11.7 +/- 0.9 months, range 6 to 22). Of 30 patients undergoing follow-up transesophageal echocardiographic studies, 20 (66%) had no change in atherosclerotic severity grade. Of the remaining 10 patients, atherosclerotic severity progressed one grade in 7 and decreased in 3 with resolved mobile lesions. Of 18 patients with grade IV or V disease of the aorta who underwent a follow-up study, 11 (61%) demonstrated formation of new mobile lesions. Of 10 patients with grade V disease on initial study who underwent follow-up study, 7 (70%) demonstrated resolution of a specific previously documented mobile lesion. However, seven patients (70%) with grade V disease also demonstrated development of a new mobile lesion. Of 33 patients with grade IV or V disease, 8 (24%) died during the study period, and 1 (3%) had a clinical embolic event. The presence of severe atherosclerotic disease of the thoracic aorta as defined by transesophageal echocardiography is associated with a high mortality rate. Although the morphologic

  18. Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses' Health Study.

    Momen-Heravi, Fatemeh; Babic, Ana; Tworoger, Shelley S; Zhang, Libin; Wu, Kana; Smith-Warner, Stephanie A; Ogino, Shuji; Chan, Andrew T; Meyerhardt, Jeffrey; Giovannucci, Edward; Fuchs, Charles; Cho, Eunyoung; Michaud, Dominique S; Stampfer, Meir J; Yu, Yau-Hua; Kim, David; Zhang, Xuehong

    2017-02-01

    Periodontal diseases including tooth loss might increase systemic inflammation, lead to immune dysregulation and alter gut microbiota, thereby possibly influencing colorectal carcinogenesis. Few epidemiological studies have examined the association between periodontal diseases and colorectal cancer (CRC) risk. We collected information on the periodontal disease (defined as history of periodontal bone loss) and number of natural teeth in the Nurses' Health Study. A total of 77,443 women were followed since 1992. We used Cox proportional hazard models to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) after adjustment for smoking and other known risk factors for CRC. We documented 1,165 incident CRC through 2010. Compared to women with 25-32 teeth, the multivariable HR (95% CI) for CRC for women with periodontal disease, HRs for CRC were 0.91 (95% CI 0.74-1.12) for periodontal disease, and 1.22 (95% CI 0.91-1.63) when limited to moderate to severe periodontal disease. The results were not modified by smoking status, body mass index or alcohol consumption. Women with fewer teeth, possibly moderate or severe periodontal disease, might be at a modest increased risk of developing CRC, suggesting a potential role of oral health in colorectal carcinogenesis. © 2016 UICC.

  19. [Chronic disease, mortality and disability in an elderly Spanish population: the FRADEA study].

    Alfonso Silguero, Sergio A; Martínez-Reig, Marta; Gómez Arnedo, Llanos; Juncos Martínez, Gema; Romero Rizos, Luis; Abizanda Soler, Pedro

    2014-01-01

    The objective of this study was to analyse the relationships between the major chronic diseases and multiple morbidity, with mortality, incident disability in basic activities of daily living, and loss of mobility in the elderly. A total of 943 participants were selected from the FRADEA Study, using available baseline data of chronic diseases, and at the follow-up visit of mortality, incident disability, and loss of mobility. The analysis was made of the unadjusted and adjusted association between the number of chronic diseases, the number of 14 pre-selected diseases, and the presence of two or more chronic diseases (multiple morbidity) with adverse health events recorded. Participants with a higher number of diseases (OR 1.11; 95% CI: 1.02-1.22), and 14 pre-selected diseases (OR 1.19; 95% CI: 1.03-1.38) had a higher adjusted mortality risk, but not a higher incident disease or mobility loss risk. Subjects with multiple morbidity had a higher non-significant mortality risk (HR 1.45; 95% CI: 0.87-2.43), than those without multiple morbidity. Disability-free mean time in participants with and without multiple morbidity was 846±34 and 731±17 days, respectively (Log-rank χ(2) 7.45. P=.006), and with our without mobility loss was 818±32 and 696±13 days, respectively (Log rank χ(2) 10.99. P=.001). Multiple morbidity was not associated with mortality, incident disability in ADL, or mobility loss in adults older than 70 years, although if mortality is taken into account, the number of chronic diseases is linear. Copyright © 2013 SEGG. Published by Elsevier Espana. All rights reserved.

  20. A Study on the Diagnostic Significance of Hepatoscintigram with Colloidal Gold in Parenchymal Liver Disease

    Shin, Dong Ho; Lee, Min Ho; Kim, Mok Hyun

    1982-01-01

    Hapatoscintigram has been a useful diagnostic method for the liver disease since 1953, but reasonable diagnostic criteria for parenchymal liver diseases are not yet accurately established. For the purpose of searching for more advanced diagnostic criteria for various types of live diseases by the liver scan, a retrospective study was made of 272 cases who underwent both hepatoscintigram with 198 Au colloid and liver biopsy in Hanyang University Hospital from Jan, 1978 to Dec, 1981. The results were as follows: 1. Fuzzy margin (irregular indentation of the liver margin) in the hepatoscintigram was noted in 226 cases (97.79%) 2. Of 35 cases with fuzzy margin only, 28 cases (80%)revealed mild parenchymal liver disease, such as acute hepatitis or chronic persistent hepatitis by the liver biopsy. 3. Mottling change (209 cases) was always accomplished by fuzzy margin except only one case, and 31 cases (86.1%) of fuzzy and mottling cases (36 cases) showed mild parenchymal liver disease. 4. Configuration change (193 cases) was usually accompanied with other changes and especially 104 cases had configuration changed with fuzzy and mottling changes. 73 cases (88.445) of 86 cases with severe configuration changed revealed advanced parenchymal liver disease on biopsy. If liver scan showed mild configuration change, we could not decide the type of liver disease only liver scan, and so further studies are needed. 5. Splenic uptake was noted 34 cases (40.48%) of 84 cases with advanced parenchymal liver disease, and the degree of splenic uptake was for the most part moderate or severe; whereas splenic uptake was noted in 18 cases (16.51%) of the mild parenchymal liver disease (109 cases), and the degree of splenic uptake was largely mild.

  1. A study on the air pollution related human diseases in Thiruvananthapuram City, Kerala

    Bency, K.T.; Jansy, J.; Thakappan, B.; Kumar, B.; Sreelekha, T.T.; Hareendran, N.K.; Nair, P.K.K.; Krishnan Nair, M. [National Inst. of Environmental Health, Thiruvananthapuram, Kerala (India). Regional Cancer Centre

    2005-07-01

    This paper contains the results of a study that examined the impacts of air pollution on human health in Thiruvananthapuram City, India. The study compared health impacts arising from air pollution in three different zones including residential, commercial, and industrial. The paper presents the findings from the study according to each of these zones and presents conclusions.The study found that each zone had its individual environmental problems which were characterized by specific diseases. In the residential zone, there was a prevalence of diseases such as breast cancer and cardiac-related problems as well as dietary problems linked to obesity. In the industrial zone, respiratory illnesses related to air pollution were prevalent. Cardiac and vector-borne diseases, related to environmental hazards like waste water stagnation, dust and solid waste problem, were high in the commercial zone. 14 refs., 3 figs.

  2. Unexplained infertility as primary presentation of celiac disease, a case report and literature review

    Mohammadreza Ghadir

    2011-01-01

    Full Text Available Background: Celiac sprue (gluten sensitive enteropathy is an autoimmune disease which is hereditary and its pathology mainly bases on immunologic intolerance to gluten. It has a vast variety of signs and symptoms and its clinical features range from a silent disease to a typical gastrointestinal disorder. In this study we reviewed and summarized some other related issues about this disease and its relation with infertility.Case: The case is a 26 years old lady who had referred to a gynecologist because of infertility for 2 years and later it revealed that she has celiac sprue.Conclusion: Screening for its silent or subtle types especially among suspicious cases such as unexplained infertility seems to be a cost effective action. Meanwhile, in time administration of a gluten-free diet can lead to an almost complete cure

  3. The Einstein Center for Epigenomics: studying the role of epigenomic dysregulation in human disease.

    McLellan, Andrew S; Dubin, Robert A; Jing, Qiang; Maqbool, Shahina B; Olea, Raul; Westby, Gael; Broin, Pilib Ó; Fazzari, Melissa J; Zheng, Deyou; Suzuki, Masako; Greally, John M

    2009-10-01

    There is increasing interest in the role of epigenetic and transcriptional dysregulation in the pathogenesis of a range of human diseases, not just in the best-studied example of cancer. It is, however, quite difficult for an individual investigator to perform these studies, as they involve genome-wide molecular assays combined with sophisticated computational analytical approaches of very large datasets that may be generated from various resources and technologies. In 2008, the Albert Einstein College of Medicine in New York, USA established a Center for Epigenomics to facilitate the research programs of its investigators, providing shared resources for genome-wide assays and for data analysis. As a result, several avenues of research are now expanding, with cancer epigenomics being complemented by studies of the epigenomics of infectious disease and a neuroepigenomics program.

  4. Early menopause predicts future coronary heart disease and stroke: the Multi-Ethnic Study of Atherosclerosis.

    Wellons, Melissa; Ouyang, Pamela; Schreiner, Pamela J; Herrington, David M; Vaidya, Dhananjay

    2012-10-01

    Cardiovascular disease is the number one killer of women. Identifying women at risk of cardiovascular disease has tremendous public health importance. Early menopause is associated with increased cardiovascular disease events in some predominantly white populations, but not consistently. Our objective was to determine if self-reported early menopause (menopause at an age menopause (either natural menopause or surgical removal of ovaries at an age menopause. In survival curves, women with early menopause had worse coronary heart disease and stroke-free survival (log rank P = 0.008 and P = 0.0158). In models adjusted for age, race/ethnicity, Multi-ethnic Study Atherosclerosis site, and traditional cardiovascular disease risk factors, this risk for coronary heart disease and stroke remained (hazard ratio, 2.08; 95% CI, 1.17-3.70; and hazard ratio, 2.19; 95% CI, 1.11-4.32, respectively). Early menopause is positively associated with coronary heart disease and stroke in a multiethnic cohort, independent of traditional cardiovascular disease risk factors.

  5. PubMed search filters for the study of putative outdoor air pollution determinants of disease

    Curti, Stefania; Gori, Davide; Di Gregori, Valentina; Farioli, Andrea; Baldasseroni, Alberto; Fantini, Maria Pia; Christiani, David C; Violante, Francesco S; Mattioli, Stefano

    2016-01-01

    Objectives: Several PubMed search filters have been developed in contexts other than environmental. We aimed at identifying efficient PubMed search filters for the study of environmental determinants of diseases related to outdoor air pollution. Methods: We compiled a list of Medical Subject Headings (MeSH) and non-MeSH terms seeming pertinent to outdoor air pollutants exposure as determinants of diseases in the general population. We estimated proportions of potentially pertinent articles to...

  6. Skeletal involvement in Gaucher disease: An observational multicenter study of prognostic factors in the Argentine Gaucher disease patients.

    Drelichman, Guillermo; Fernández Escobar, Nicolás; Basack, Nora; Aversa, Luis; Larroude, María Silvia; Aguilar, Gabriela; Szlago, Marina; Schenone, Andrea; Fynn, Alcyra; Cuello, María Fernanda; Aznar, Marcela; Fernández, Ramiro; Ruiz, Alba; Reichel, Paola; Guelbert, Norberto; Robledo, Hugo; Watman, Nora; Bolesina, Moira; Elena, Graciela; Veber, S Ernesto; Pujal, Graciela; Galván, Graciela; Chain, Juan José; Arizo, Adriana; Bietti, Julieta; Bar, Daniel; Dragosky, Marta; Marquez, Marisa; Feldman, Leonardo; Muller, Katja; Zirone, Sandra; Buchovsky, Greogorio; Lanza, Victoria; Sanabria, Alba; Fernández, Ignacio; Jaureguiberry, Rossana; Contte, Marcelo; Barbieri María, Angie; Maro, Alejandra; Zárate, Graciela; Fernández, Gabriel; Rapetti, María Cristina; Donato, Hugo; Degano, Adriana; Kantor, Gustavo; Albina, Roberto; Á Lvarez Bollea, María; Brun, María; Bacciedoni, Viviana; Del Río, Francis; Soberón, Bárbara; Boido, Nazario; Schweri, Maya; Borchichi, Sandra; Welsh, Victoria; Corrales, Marcela; Cedola, Alejandra; Carvani, Analía; Diez, Blanca; Richard, Lucía; Baduel, Ccecilia; Nuñez, Gabriela; Colimodio, Rubén; Barazzutti, Lucía; Medici, Hugo; Meschengieser, Susana; Damiani, Germán; Nucifora, María; Girardi, Beatriz; Gómez, Sergio; Papucci, Maura; Verón, David; Quiroga, Luis; Carro, Gustavo; De Ambrosio, Patricia; Ferro, José; Pujol, Marcelo; Castella, Cristina Cabral; Franco, Liliana; Nisnovich, Gisela; Veloso, María; Pacheco, Isabel; Savarino, Mario; Marino, Andrés; Saavedra, José Luis

    2016-10-01

    Patients with Gaucher type 1 (GD1) throughout Argentina were enrolled in the Argentine bone project to evaluate bone disease and its determinants. We focused on presence and predictors of bone lesions (BL) and their relationship to therapeutic goals (TG) with timing and dose of enzyme replacement therapy (ERT). A total of 124 patients on ERT were enrolled in a multi-center study. All six TG were achieved by 82% of patients: 70.1% for bone pain and 91.1% for bone crisis. However, despite the fact that bone TGs were achieved, residual bone disease was present in 108 patients on ERT (87%) at time 0. 16% of patients showed new irreversible BL (bone infarcts and avascular osteonecrosis) despite ERT, suggesting that they appeared during ERT or were not detected at the moment of diagnosis. We observed 5 prognostic factors that predicted a higher probability of being free of bone disease: optimal ERT compliance; early diagnosis; timely initiation of therapy; ERT initiation dose ≥45 UI/kg/EOW; and the absence of history of splenectomy. Skeletal involvement was classified into 4 major phenotypic groups according to BL: group 1 (12.9%) without BL; group 2 (28.2%) with reversible BL; group 3 (41.9%) with reversible BL and irreversible chronic BL; and group 4 (16.9%) with acute irreversible BL. Our study identifies prognostic factors for achieving best therapeutic outcomes, introduces new risk stratification for patients and suggests the need for a redefinition of bone TG. Am. J. Hematol. 91:E448-E453, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. The Peripheral Arterial disease study (PERART/ARTPER: prevalence and risk factors in the general population

    Vicheto Marisa

    2010-01-01

    Full Text Available Abstract Background The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease. The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population. Methods We performed a cross-sectional, multicentre, population-based study in 3786 individuals >49 years, randomly selected in 28 primary care centres in Barcelona (Spain. Peripheral arterial disease was evaluated using the ankle-arm index. Values Results The prevalence (95% confidence interval of peripheral arterial disease was 7.6% (6.7-8.4, (males 10.2% (9.2-11.2, females 5.3% (4.6-6.0; p Multivariate analysis showed the following risk factors: male sex [odds ratio (OR 1.62; 95% confidence interval 1.01-2.59]; age OR 2.00 per 10 years (1.64-2.44; inability to perform physical activity [OR 1.77 (1.17-2.68 for mild limitation to OR 7.08 (2.61-19.16 for breathless performing any activity]; smoking [OR 2.19 (1.34-3.58 for former smokers and OR 3.83 (2.23-6.58 for current smokers]; hypertension OR 1.85 (1.29-2.65; diabetes OR 2.01 (1.42-2.83; previous cardiovascular disease OR 2.19 (1.52-3.15; hypercholesterolemia OR 1.55 (1.11-2.18; hypertriglyceridemia OR 1.55 (1.10-2.19. Body mass index ≥25 Kg/m2 OR 0.57 (0.38-0.87 and walking >7 hours/week OR 0.67 (0.49-0.94 were found as protector factors. Conclusions The prevalence of peripheral arterial disease is low, higher in males and increases with age in both sexes. In addition to previously described risk factors we found a protector effect in physical exercise and overweight.

  8. Generation of a conditional knockout of murine glucocerebrosidase: utility for the study of Gaucher disease.

    Sinclair, Graham B; Jevon, Gareth; Colobong, Karen E; Randall, Derrick R; Choy, Francis Y M; Clarke, Lorne A

    2007-02-01

    Gaucher disease is a disorder of sphingolipid metabolism resulting from an inherited deficiency of the lysosomal hydrolase glucocerebrosidase. Affected individuals present with a spectrum of clinical symptoms ranging from hepatosplenomegaly, haematological abnormalities, and bone pain in type 1 disease, to severe neurodegeneration and premature death in types 2 and 3 disease. Although the basic biochemical defect is well characterized, there remains a poor understanding of the underlying pathophysiology of disease. In vitro studies suggest that macrophage glucocerebroside storage leads to tissue dysfunction through complex mechanisms involving altered intracellular calcium homeostasis and apoptosis. In order to study the pathogenic roles of these complex interactions, a viable animal model for Gaucher disease is needed. The complexity of this single gene disorder has been emphasized by the varied results of previous murine Gaucher models, ranging from perinatal lethality to phenotypically and biochemically asymptomatic animals. Recognizing the need to modulate the biochemical phenotype in mice to produce a relevant model, we have created a murine strain with key exons of the glucocerebrosidase gene flanked by loxP sites. We show that expression of Cre-recombinase in cells of hematopoietic and endothelial origin results in deficiency of glucocerebrosidase in the liver, spleen, bone marrow, and peripheral white cells. Glucocerebroside storage in this model leads to progressive splenomegaly with Gaucher cell infiltration and modest storage in the liver by 26 weeks of age. These results indicate the utility of this loxP GBA targeted murine strain for understanding the complex pathophysiology of Gaucher disease.

  9. Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC epidemiological study

    Kang Xiaoping

    2010-11-01

    Full Text Available Abstract Background Gastroesophageal reflux disease imposes a significant burden of illness in Western populations. However, data on the impact of reflux symptoms on daily life in Asian populations are scarce. The current study aimed to evaluate the impact of GERD (defined on the basis of symptoms on health-related quality-of-life (HRQoL in individuals from five regions in China, as part of the Systematic Investigation of Gastrointestinal Diseases in China (SILC study. Methods In total, 18 000 residents were randomly selected from across five regions of China and asked to complete a general information questionnaire and a Chinese version of the Reflux Disease Questionnaire (RDQ. A randomly selected subsample of one-fifth of subjects (20% from each region completed Chinese versions of the 36-item self-administered (SF-36 questionnaire and Epworth Sleepiness Scale (ESS questionnaire. Reflux symptoms were defined as the presence of heartburn and/or regurgitation. Symptom-defined GERD was diagnosed as mild heartburn and/or regurgitation ≥2 days per week, or moderate/severe heartburn and/or regurgitation ≥1 day a week, based on the Montreal Definition of GERD for population-based studies. Results The response rate was 89.4% for the total sample (16 091/18 000, and for the 20% subsample (3219/3600. Meaningful impairment was observed in all 8 SF-36 dimensions in participants with symptom-defined GERD, in 7 of the 8 SF-36 dimensions in participants with troublesome reflux symptoms, and in 6 of the 8 SF-36 dimensions in participants with reflux symptoms below the threshold for symptom-defined GERD. Meaningful daytime sleepiness was also observed in each of these groups. The proportion of individuals reporting troublesome symptoms increased as reflux symptom frequency and severity approached the threshold for symptom-defined GERD, and this was associated with concomitant decreases in all HRQoL measures. Troublesome symptoms were reported by 68.2% (75

  10. Defining interdisciplinarity and indentifying Research directions in Jani Christou’s Strychnine lady

    Maria Yerosimou

    2014-09-01

    Full Text Available Jani Christou was a major Greek composer, whose unusual, yet promising career was brought to an end after his untimely death in 1970 at the age of 44. His challenging and speculative output has intrigued generation of young music scholars; however, J. Christou’s work remains imperfectly and only patchily known and understood, especially outside Greece. This is partly because of the interdisciplinary nature of his late works which reduces the possibility of potential researchers who will academically establish J. Christou’s distinguished output. The aim of the present paper is to present and analyse parts of Strychnine Lady, a work composed in 1967 in order to propose research directions in an effort to confirm J. Christou’s posthumous reputation.

  11. An epidemiological study of the association of coffee with chronic liver disease.

    Walton, H B; Masterton, G S; Hayes, P C

    2013-11-01

    Chronic liver disease affects 855 people per million in the UK. Previous studies have reported that coffee appears protective against the development of abnormal liver enzymes, hepatic fibrosis and cirrhosis. The aim of this study, the first in a Scottish population, was to compare coffee consumption in patients with liver disease and that of control populations to determine correlations between coffee intake and the incidence of non-cancerous liver disease and with Child's-Pugh and model for end-stage liver disease (MELD) scores. Two hundred and eighty-six patients attending the liver outpatient department at the Royal Infirmary of Edinburgh completed a questionnaire regarding coffee consumption and lifestyle factors. Control questionnaires were also completed by 100 orthopaedic outpatients and 120 medical students. Patients with cirrhosis (n = 95) drank significantly less coffee than those without cirrhosis (p = coffee consumption. Coffee drinking is associated with a reduced prevalence of cirrhosis in patients with chronic liver disease. However, there was no significant difference in the amount of coffee drunk by liver patients and the control groups. It is possible that by changing the amount of coffee drunk, the development of cirrhosis in liver disease could be postponed.

  12. Cognition and Incident Coronary Heart Disease in Late Midlife: The Whitehall II Study

    Singh-Manoux, Archana; Sabia, Severine; Kivimaki, Mika; Shipley, Martin J.; Ferrie, Jane E.; Marmot, Michael G.

    2009-01-01

    The purpose of this study was to investigate whether cognitive function in midlife predicts incident coronary heart disease (CHD), followed up over 6 years. Data on 5292 (28% women, mean age 55) individuals free from CHD at baseline were drawn from the British Whitehall II study. We used Cox regression to model the association between cognition…

  13. A clinical study in elderly patients with Parkinson's disease using MRI and SPECT; Parkinson's disease and the lacunar state

    Umahara, Takahiko; Iwamoto, Toshihiko; Takasaki, Masaru; Katsunuma, Hideyo [Tokyo Medical Coll. (Japan)

    1991-11-01

    Parkinson's disease (PD) is often associated with dementia in elderly patients, and sometimes PD coexists with senile dementia of the Alzheimer type (SDAT) or cerebrovascular disease (CVD) in the elderly. However, since there are few previous clinical studies on the coincidence of, or relationship between PD and CVD, the authors evaluated these aspects in 34 elderly patients with PD using MRI and SPECT. All the patients were over 70 years old. The diagnosis of PD was based on the presence of three symptons (resting tremor, cogwheel rigidity and bradikinesia) which are characteristic of PD, and the effectiveness of L-DOPA therapy. We therefore believe that patients with vascular Parkinsonism were excluded from our study. In 34 cases, 24 (71%) had MRI evidence of CVD (mainly the lacunar state). In the 10 cases who had no CVD, 2 (20%) had severe dementia and the decrease of regional cerebral blood flow (rCBF) in the temporal and parietal lobes bilaterally correlated with the SPECT findings commonly found in SDAT. A comparison of the rCBF and the results of Hasegawa's dementia score (HDS) (verbal intelligence score) was made between the patients with PD associated with CVD and the patients with PD who had no CVD and no SPECT findings which correlated with SDAT. The rCBF in the frontal lobes and the results of the HDS of the former group were significantly lower than those of the latter. As mentioned above, elderly patients with PD often had CVD, leading to dementia. We also pointed out the difficulty in making a differential diagnosis between PD with CVD and vascular Parkinsonism, and the necessity of whether or not the concept of 'mixed type Parkinsonism' should be considered. (author).

  14. Interdiscursividade e metadiscursividade no videoclipe Applause, de Lady Gaga

    Lúcio Flávio Gondim da Silva

    2015-08-01

    Full Text Available Nesta pesquisa, fazemos, com base no arcabouço conceitual da Análise do Discurso, na perspectiva de Maingueneuau (2005, uma análise do clipe Applause (2013, da cantora norte-americana Lady Gaga. Identificamos as relações interdiscursivas e metadiscursivas presentes na obra e analisamos de que modo elas ocorrem. No decorrer do trabalho, foi possível observar que há, no clipe, uma forte presença da metadiscursividade, revelada desde o título da canção até os elementos construídos voltados a este fim. Quanto à interdiscursividade, ela surge em grande número e interliga o discurso literomusical ao qual o clipe pertence aos discursos de grandes correntes estéticas e movimentos de arte, bem como de outras linguagens artísticas, como o cinema, a moda e o teatro.

  15. A qualitative descriptive study of risk reduction for coronary disease among the Hong Kong Chinese.

    Chan, Choi Wan; Lopez, Violeta

    2014-01-01

    Achieving optimal control and reduction in coronary heart disease (CHD) risks in Hong Kong (HK) remains significant and requires exploring. This article addresses the ability to reduce CHD risks among the HK Chinese. Through secondary analysis, a qualitative descriptive design using focus group interviews and content analysis were adopted. Older and younger adults were invited for the study. An interview schedule was used to guide discussions during focus group interviews. Four categories emerged from the data: planning of health actions, control of risk-reducing behavior, perceived opportunities for understanding CHD, and chest pain appraisal. Local culture and population needs play a central role in disease perception and prevention. The findings are essential to target strategies for initiating health acts for younger adults and establish public education resources that underscore understanding of CHD risk, symptom recognition, and disease management, particularly among those middle-aged and older people at high risk and with the diseased populations. © 2013 Wiley Periodicals, Inc.

  16. “Gestaltomics”: Systems Biology Schemes for the Study of Neuropsychiatric Diseases

    Nora A. Gutierrez Najera

    2017-05-01

    Full Text Available The integration of different sources of biological information about what defines a behavioral phenotype is difficult to unify in an entity that reflects the arithmetic sum of its individual parts. In this sense, the challenge of Systems Biology for understanding the “psychiatric phenotype” is to provide an improved vision of the shape of the phenotype as it is visualized by “Gestalt” psychology, whose fundamental axiom is that the observed phenotype (behavior or mental disorder will be the result of the integrative composition of every part. Therefore, we propose the term “Gestaltomics” as a term from Systems Biology to integrate data coming from different sources of information (such as the genome, transcriptome, proteome, epigenome, metabolome, phenome, and microbiome. In addition to this biological complexity, the mind is integrated through multiple brain functions that receive and process complex information through channels and perception networks (i.e., sight, ear, smell, memory, and attention that in turn are programmed by genes and influenced by environmental processes (epigenetic. Today, the approach of medical research in human diseases is to isolate one disease for study; however, the presence of an additional disease (co-morbidity or more than one disease (multimorbidity adds complexity to the study of these conditions. This review will present the challenge of integrating psychiatric disorders at different levels of information (Gestaltomics. The implications of increasing the level of complexity, for example, studying the co-morbidity with another disease such as cancer, will also be discussed.

  17. THE EVALUATION OF FREQUENCY AND SEASONAL VARIATIONS OF ACID PEPTIC DISEASE: A SEVEN YEARS STUDY

    Syed Iftikhar Haider

    2016-06-01

    Full Text Available Acid peptic disease (APD is a worldwide health problem. It includes a variety of inflammatory and ulcerative lesions involving esophagus, stomach and duodenum. The disease condition may persist with multiple symptoms, one of them being dyspepsia. The object of the present study was to determine the frequency and seasonal variations of APD in patients presenting with dyspeptic symptoms. This observational study was carried out at the endoscopy unit in Baqai Medical University from December 2003 to December 2010, over a period of seven years. The evolution of APD frequency remained equivocal throughout the study period. However, a decline was noted in the frequency of peptic ulcer disease (PUD especially for gastric and duodenal ulcer cases but a rise during autumn and winter seasons was also noted in duodenal ulcer cases.

  18. Comparative Study on the Long-Acting Thyroid Stimulator in Graves' Disease

    Kim, Dong Sup; Koh, Chang Soon; Lee, Mun Ho

    1973-01-01

    In order to study the role of LATS in the pathogenesis of the Graves' disease, the serum activity of the LATS was determined by the bioassay of the modified McKenzie method. The subjects examined in the study consisted of 76 individuals including 12 cases of normal control, 54 cases with typical Graves' disease and 10 cases of chronic thyroiditis. The data observed in the patients with the Graves' disease were analyzed in comparison with the clinical features, laboratory findings, and responsiveness to the treatment. The results obtained are as follows: 1) None of the subjects which did not have the Graves' disease showed a positive LATS activity, except one case with the chronic thyroiditis. 2) Twenty-two oui of the 54 cases with the Graves' disease showed positive results for LATS (40.7%). The positivity was significantly higher in the patients who had been treated with antithyroid regimen but still showed hyperthyroidism than in the patients who had not been treated. 3) The activity of LATS was gradually decreased or even became absent as the hyperthyroidism was corrected after the treatment. 4) No significant difference was noticed in age and-sex between the positive and negative groups of LATS. 5) There was no evidence of significant correlation between the LATS activity and clinical features.

  19. Research strategies and the use of nutrient biomarkers in studies of diet and chronic disease.

    Prentice, Ross L; Sugar, Elizabeth; Wang, C Y; Neuhouser, Marian; Patterson, Ruth

    2002-12-01

    To provide an account of the state of diet and chronic disease research designs and methods; to discuss the role and potential of aggregate and analytical observational studies and randomised controlled intervention trials; and to propose strategies for strengthening each type of study, with particular emphasis on the use of nutrient biomarkers in cohort study settings. Observations from diet and disease studies conducted over the past 25 years are used to identify the strengths and weaknesses of various study designs that have been used to associate nutrient consumption with chronic disease risk. It is argued that a varied research programme, employing multiple study designs, is needed in response to the widely different biases and constraints that attend aggregate and analytical epidemiological studies and controlled intervention trials. Study design modifications are considered that may be able to enhance the reliability of aggregate and analytical nutritional epidemiological studies. Specifically, the potential of nutrient biomarker measurements that provide an objective assessment of nutrient consumption to enhance analytical study reliability is emphasised. A statistical model for combining nutrient biomarker data with self-report nutrient consumption estimates is described, and related ongoing work on odds ratio parameter estimation is outlined briefly. Finally, a recently completed nutritional biomarker study among 102 postmenopausal women in Seattle is mentioned. The statistical model will be applied to biomarker data on energy expenditure, urinary nitrogen, selected blood fatty acid measurements and various blood micronutrient concentrations, and food frequency self-report data, to identify study subject characteristics, such as body mass, age or socio-economic status, that may be associated with the measurement properties of food frequency nutrient consumption estimates. This information will be crucial for the design of a potential larger nutrient

  20. Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study

    Viard, Jean-Paul; Souberbielle, Jean-Claude; Kirk, Ole

    2011-01-01

    BACKGROUND:: We examined the association between vitamin D [25(OH)D] level and disease progression in HIV infection. METHODS:: Within the EuroSIDA study, 2000 persons were randomly selected for 25(OH)D measurement in stored plasma samples closest to study entry. 25(OH)D results were stratified...

  1. Dietary patterns are associated with disease risk among participants in the women's health initiative observational study

    Coronary heart disease (CHD) is the leading cause of death in women. A nested case-control study tested whether dietary patterns predicted CHD events among 1224 participants in the Women’s Health Initiative-Observational Study (WHI-OS) with centrally confirmed CHD, fatal or nonfatal myocardial infar...

  2. The European Respiratory Society study on chronic obstructive pulmonary disease (EUROSCOP) : recruitment methods and strategies

    Lofdahl, CG; Postma, DS; Laitinen, LA; Ohlsson, SV; Pauwels, RA; Pride, NB

    The European Respiratory Society's study on chronic obstructive pulmonary disease (EUROSCOP) is a multicentre study performed initially in 12 countries to assess the effect of 3 years' treatment with inhaled corticosteroids on lung function decline in smokers with chronic obstructive pulmonary

  3. A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer's Disease.

    Edgünlü, Tuba Gökdoğan; Ozge, Aynur; Yalın, Osman Özgür; Kul, Seval; Erdal, Mehmet Emin

    2013-09-01

    Excessive apoptosis is believed to play a role in many degenerative and non-degenerative neurological diseases including Alzheimer's disease (AD). Much recent data suggest that apoptotic mechanisms may represent the missing link between Aβ deposition and proteolysis of tau protein. However, there is emerging evidence that apoptotic mechanisms may play a role in Alzheimer's Disease pathogenesis in the absence of overt apoptosis. TNF-related apoptosis inducing ligand receptor 1 (Death Receptor 4, DR4) might impair the apoptotic signal transduction and lead to dysregulation of the homeostasis between cell survival and cell death. The aim of our study was to further investigate the relationship between genetic variants of DR4 and Alzheimer's Disease. Case control study. Sixty-eight patients with AD were included in the study. The control group comprised 72 subjects without signs of neurodegenerative diseases, as evidenced by the examination.DNA was extracted from whole blood using the salting-out procedure. Genotypes were identified by restriction fragment length polymorphism analysis of polymerase chain reaction (PCR-RFLP) products. We observed significant differences in the genotypic distribution of the rs6557634 polymorphism in AD patients compared with controls (p0.05) and the DR4 rs20576 polymorphism (p>0.05). According to haplotype analysis of the DR4 gene for rs6557634, rs20575 and rs20576 polymorphisms, GCA and GCC haplotypes might be a risk factor for AD. Also, we have shown that ACA, GGC and GGA haplotypes might be protective factors against AD. The present results indicate for the first time the possible contribution of the DR4 gene rs6557634, rs20575, rs20576 polymorphisms in Alzheimer's Disease, which may influence susceptibility to Alzheimer's Disease.

  4. Impulse control disorders in advanced Parkinson's disease with dyskinesia: The ALTHEA study.

    Biundo, Roberta; Weis, Luca; Abbruzzese, Giovanni; Calandra-Buonaura, Giovanna; Cortelli, Pietro; Jori, Maria Cristina; Lopiano, Leonardo; Marconi, Roberto; Matinella, Angela; Morgante, Francesca; Nicoletti, Alessandra; Tamburini, Tiziano; Tinazzi, Michele; Zappia, Mario; Vorovenci, Ruxandra Julia; Antonini, Angelo

    2017-11-01

    Impulse control disorders and dyskinesia are common and disabling complications of dopaminergic treatment in Parkinson's disease. They may coexist and are possibly related. The objectives of this study were to assess the frequency and severity of impulse control disorders in Parkinson's disease patients with dyskinesia. The ALTHEA study enrolled 251 Parkinson's disease patients with various degrees of dyskinesia severity from 11 movement disorders centers in Italy. Each patient underwent a comprehensive assessment including Unified Dyskinesia Rating Scale and the Questionnaire for Impulsive Compulsive Disorders in Parkinson Disease-Rating Scale. There was an overall 55% frequency of impulse control disorder and related behaviors (36% were clinically significant). The positive patients were younger at disease diagnosis and onset and had higher Unified Dyskinesia Rating Scale historical and total score (P = 0.001 and P = 0.02, respectively, vs negative). There was an increased frequency of clinically significant impulse control disorders in patients with severe dyskinesia (P = 0.013), a positive correlation between the questionnaire total score and dopamine agonist dose (P = 0.018), and a trend with levodopa dose. More than half of Parkinson's disease patients with dyskinesia have impulse control disorders and related behaviors, which are frequently clinically significant. Dopaminergic therapy total dose is associated with their severity. Clinicians should carefully assess patients with maladaptive behaviors and dyskinesia because they do not properly evaluate their motor and nonmotor status. © 2017 International Parkinson and Movement Disorder Society. © 2017 International Parkinson and Movement Disorder Society.

  5. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

    Gabriel, Sherine E; Michaud, Kaleb

    2009-01-01

    Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions – a reflection of the impact of genetic and environmental factors. The past decade has also brought new insights regarding the comorbidity associated with rheumatic diseases. Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population. Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions. PMID:19519924

  6. Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts.

    Ma, Jiantao; Fox, Caroline S; Jacques, Paul F; Speliotes, Elizabeth K; Hoffmann, Udo; Smith, Caren E; Saltzman, Edward; McKeown, Nicola M

    2015-08-01

    Non-alcoholic fatty liver disease affects ∼30% of US adults, yet the role of sugar-sweetened beverages and diet soda on these diseases remains unknown. We examined the cross-sectional association between intake of sugar-sweetened beverages or diet soda and fatty liver disease in participants of the Framingham Offspring and Third Generation cohorts. Fatty liver disease was defined using liver attenuation measurements generated from computed tomography in 2634 participants. Alanine transaminase concentration, a crude marker of fatty liver disease, was measured in 5908 participants. Sugar-sweetened beverage and diet soda intake were estimated using a food frequency questionnaire. Participants were categorized as either non-consumers or consumers (3 categories: 1 serving/month to sugar-sweetened beverages or diet soda. After adjustment for age, sex, smoking status, Framingham cohort, energy intake, alcohol, dietary fiber, fat (% energy), protein (% energy), diet soda intake, and body mass index, the odds ratios of fatty liver disease were 1, 1.16 (0.88, 1.54), 1.32 (0.93, 1.86), and 1.61 (1.04, 2.49) across sugar-sweetened beverage consumption categories (p trend=0.04). Sugar-sweetened beverage consumption was also positively associated with alanine transaminase levels (p trend=0.007). We observed no significant association between diet soda intake and measures of fatty liver disease. In conclusion, we observed that regular sugar-sweetened beverage consumption was associated with greater risk of fatty liver disease, particularly in overweight and obese individuals, whereas diet soda intake was not associated with measures of fatty liver disease. Copyright © 2015 European Association for the Study of the Liver. All rights reserved.

  7. The interventional diagnosis and therapy for thyroid disease should be studied deeply and developed prudently

    Zhao Wei; Cheng Yongde

    2007-01-01

    Many details concerning the interventional diagnosis and therapy of thyroid disease need to be studied deeply and carefully; for example, the thyroid applied anatomy, especially the anatomical imageology study of the thyroid arterial anastomosis involving the therapeutic effects and complications, the thyroid artery embolization treatment, presently as a substitution or the supplement therapy for the traditional classical therapy of Graves disease. There are many exploration to extend the indication scope, the therapeutic effect, embolization scope in intervention for Graves disease due to having no accurate individual quantification standard, and so on. The thyroid arterial embolization for Graves disease is to reduce the main cause of thyroxin secretion. Simultaneously, the comprehensive therapeutic effects might have possibly produce the thyroidcytic apoptosis and immune adjustments. Serious complications such as the cerebral infarction, the hyperthyroidism crisis, the hypocalcemia, the periodic paralysis, and so on commonly occured in thyroid arterial embolization. It is necessary to keep strictly the procedure rule and the indication. The mid-and long- term therapeutic effect of thyroid artery embolization for Graves disease is good, but still need more extensive and prudent research for the prospective achievement. (authors)

  8. High androgens in postmenopausal women and the risk for atherosclerosis and cardiovascular disease: the Rotterdam Study.

    Meun, Cindy; Franco, Oscar H; Dhana, Klodian; Jaspers, Loes; Muka, Taulant; Louwers, Yvonne; Ikram, M Arfan; Fauser, Bart C J M; Kavousi, Maryam; Laven, Joop S E

    2018-02-01

    Polycystic ovary syndrome (PCOS) is closely linked to hyperandrogenism. In PCOS, hyperandrogenism has been associated with metabolic disturbances which increase the risk for cardiovascular disease (CVD). To assess the association of high serum androgen levels, as a postmenopausal remnant of PCOS, with the prevalence of atherosclerosis and incidence of CVD in postmenopausal women. The Rotterdam Study, a prospective population-based cohort study. Median follow up was 11.36 years. General community. 2578 women aged over 55. Exclusion criteria were missing informed consent or follow-up data, perimenopausal status, menopause by surgical intervention or at an unnatural age (age 62). None. Linear, logistic, and cox regression models assessed the association of top quartiles (P75) of serum testosterone, free androgen index (FAI), dehydroepiandrosterone, and androstenedione and SHBG with coronary artery calcium, carotid intima media thickness (IMT), pulse wave velocity, peripheral artery disease and incidence of coronary heart disease, stroke, and CVD. Mean age (standard deviation) was 70.19 (8.71) years and average time since menopause 19.85 (9.94) years. Highest quartile FAI was associated with higher pulse wave velocity [β (95%CI): 0.009 (0.000;0.018)]. Highest quartile dehydroepiandrosterone [β (95%CI): -0.008 (-0.015;-0.001)] and androstenedione [β (95%CI): -0.010 (-0.017;-0.003)] levels were associated with a lower IMT. We found no association between high androgen levels and incident stroke, coronary heart disease, or cardiovascular disease. Postmenopausal high androgen levels were not associated with an increased risk for CVD. Cardiovascular health in women with PCOS might be better than was anticipated. Copyright © 2018 Endocrine Society

  9. The impact of skin diseases on quality of life: A multicenter study.

    Sanclemente, G; Burgos, C; Nova, J; Hernández, F; González, C; Reyes, M I; Córdoba, N; Arévalo, Á; Meléndez, E; Colmenares, J; Ariza, S; Hernández, G

    2017-04-01

    To date, no formal study has been published regarding how Colombian patients with skin disorders could be affected according to their perception of disease. To determine the impact in quality of life of skin diseases in a Colombian population. This multicenter study included patients with skin disease from almost the whole country. Individuals >18 years old; of any gender; with any skin disease and who signed informed consent, were included. We applied the Colombian validated version of the Skindex-29 instrument. A total of 1896 questionnaires had sufficient information for the analyses. No significant differences in sociodemographic characteristics of patients who returned the questionnaire incomplete vs. complete, were found. Participants mean age was 41.5 years. There were no statistical differences in men vs. women regarding the global (p=0.37), symptoms (p=0.71) and emotions (p=0.32) domains, whereas statistical differences were found in the function domain (p=0.04; Mann-Whitney U test). Psoriasis, contact dermatitis, atopic dermatitis, urticaria, hair disorders, Hansen's disease, scars, hyperhidrosis and genital human papillomavirus disease scored the highest. Skindex-29 score variability as a result of differences in the location of the skin lesions, their inflammatory or non-inflammatory nature, and the start of therapy. Even the most localized or asymptomatic skin lesion in our population leads to a disruption at some level of patient's wellness. This study adds well supported scientific data of the burden of skin diseases worldwide. Copyright © 2016 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. [The Study of Psychological Characteristics of Children and Adolescents with Digestive Diseases].

    Sviridova, T V; Lazurenko, S B; Venger, A L; Komarova, E V; Potapov, A S; Buslaeva, A S

    2015-01-01

    The present study was aimed at the psychological characteristics of children with different chronic diseases of the digestive system and the identification of key factors influencing the formation of their personality. The continuous prospective study of psychological peculiarities of 125 patients (7-17 y.o.) with diseases of the digestive system who have been monitored at Scientific Centre of Children's Health (Moscow) was performed. As research methods were used: analysis of medical and pedagogical documentation, participant observation, educational experiment, interview, questionnaires and projective methods. The study involved 125 patients aged 7-17 years (12.4 averagely) with diseases of the digestive system including teens--68 (54%), primary school pupil--57 (46%). The number of boys significantly prevailed over the number of girls (2:1). The study confirmed the existence of a close relationship and mutual influence of three factors: the physical condition, social situation of development, and individual psychological characteristics of children. According to the psychological characteristics the children can be combined in three groups: Group I (47 of 125 people; 37.6%) - children with bad psychological status. This is most typicalfor children with active form of chronic diseases requiring intensive medical assistance (37 of 47people; 78.7%). Group II (59 of 125 people; 47.2%)--children with instable psychological condition, with risk of neurotization. This group mainly comprises patients with chronic diseases at the stage of unstable clinical remission with preserved or compensated functions of organism bodies and systems or with incomplete compensation of functions requiring long term supportive treatment (45 of 59 people; 76.3%). Group III--patients with rather stable psychological condition (19 of 125 people; 15.2%). It comprises patients with rather stable psychological condition, anyway, with expressed psychological vulnerability in stress situation

  11. Risk Factors Associated with Childhood Strabismus: The Multi-Ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease Studies

    Cotter, Susan; Varma, Rohit; Tarczy-Hornoch, Kristina; McKean-Cowdin, Roberta; Lin, Jesse; Wen, Ge; Wei, Jolyn; Borchert, Mark; Azen, Stan; Torres, Mina; Tielsch, James M.; Friedman, David S.; Repka, Michael X.; Ibironke, Joanne Katz Josephine; Giordano, Lydia

    2011-01-01

    Objective To investigate risk factors associated with esotropia or exotropia in infants and young children. Design Population-based cross-sectional prevalence study. Participants Population-based samples of 9970 children ages 6 to 72 months from California and Maryland. Methods Participants were preschool African-American, Hispanic, and non-Hispanic white children participating in the Multiethnic Pediatric Eye Disease Study and the Baltimore Eye Disease Study. Data were obtained by parental interview and ocular examination. Odd ratios and 95% confidence intervals were calculated to evaluate the association of demographic, behavioral, and clinical risk factors with esotropia and exotropia. Main Outcome Measures Odds ratios (ORs) for various risk factors associated with esotropia or exotropia diagnosis based on cover testing. Results In multivariate logistic regression analysis, esotropia was independently associated with prematurity, maternal smoking during pregnancy, older preschool age (48–72 months), anisometropia, and hyperopia. There was a severity-dependent association of hyperopia with the prevalence of esotropia, with ORs increasing from 6.4 for 2.00 Diopters (D) to strabismus, female sex, astigmatism (OR 2.5 for 1.50 to <2.50 D, and 5.9 for ≥ 2.5 D of astigmatism), and aniso-astigmatism in the J0 component (OR ≥ 2 for J0 aniso-astigmatism ≥ 0.25 D). Conclusions Prematurity and maternal smoking during pregnancy are associated with a higher risk of having esotropia and exotropia. Refractive error is associated in a severity-dependent manner to the prevalence of esotropia and exotropia. Because refractive error is correctable, these risk associations should be considered when developing guidelines for the screening and management of refractive error in infants and young children children. PMID:21856012

  12. The epidemiologic study of children diseases under one year in Tehran

    Babaeei Gh

    2001-07-01

    Full Text Available Infant mortality and morbidity present important challenges to those concerned with community health. We did this research to study epidemiology of diseases of infancy in city of Tehran. During 15 days, of 6395 deliveries in Tehran hospitals a cohort of 6267 live births entered this study. Follow up data were gathered in 1st, 3rd, 6th and 12th months of birth. In this period, 5382 occurrence of disease were reported. The most frequent were cardiopulmonary (52.3% and Gastrointestinal (26.6% diseases. Most of the events were seen in 6-12 months age group (30.5%. The lowest frequencies of infant diseases were seen in 19-35 years of maternal age (15.3%, as compared with >35 (35.4% and <19 (49.3% groups. Mortality ratio was 32/1000 live birth (198 death. The most common causes of death were cardiopulmonary (38%, infectious (21% and gastrointestinal (18% diseases. Control of infectious disease, development of educational programs for breast feeding and planning of proper age and interval of pregnancy are effective measures for reducing infant mortality and morbidity.

  13. Delayed-Start Analyses in the Phase 3 Solanezumab EXPEDITION3 Study in Mild Alzheimer's Disease.

    Liu-Seifert, H; Case, M G; Andersen, S W; Holdridge, K C; Aisen, P S; Kollack-Walker, S; Siemers, E

    2018-01-01

    A delayed-start design has been proposed to assess a potential disease-modifying effect in investigational drugs for Alzheimer's disease that target the underlying disease process. We extended this methodology to recently obtained data from the EXPEDITION3. EXPEDITION3 was a Phase 3, double-blind study with participants randomized to solanezumab (400 mg) or placebo every 4 weeks for 80 weeks, with an optional extension of active treatment. The delayed-start analysis was designed to determine if a statistically significant treatment difference established during the placebo-controlled period is maintained (at predefined level) during the delayed-start period, which would suggest the active drug has a disease-modifying effect. The delayed-start analysis was assessed across multiple efficacy measures, and includes data from baseline in the placebo-controlled period and up to 9 months in the delayed-start period. No significant difference was observed between the placebo and solanezumab treatment groups at the end of the placebo-controlled period for the Alzheimer's Disease Assessment Scale-Cognitive 14-item subscale. A significant treatment difference was observed at the end of the placebo-controlled period for the Alzheimer's Disease Cooperative Study-Activities of Daily Living instrumental items, an effect also seen at 6 months in the delayed-start period, and the noninferiority criterion was met. No other efficacy measures met these criteria. Delayed-start statistical methodology was used to understand the longitudinal outcomes in EXPEDITION3 and its extension. The small treatment differences observed at the end of the placebo-controlled phase prevented adequate assessment of any putative disease modifying effect.

  14. Nuclear technology and chronic diseases: an exploratory study evolving the clinical physician perception

    Sato, Renato Cesar

    2010-01-01

    This research is an exploratory cross-sectional study about the relationship of chronic disease and the use of nuclear technology. There is a concern over the increase of the prevalence of chronic disease in developing countries and it should hence be carefully evaluated in the context of societies, organizations and individuals. The technological advances experienced in the last decades especially in the nuclear technology area have created expectations to deal more efficiently with the challenge of chronic diseases. However little has been explored in this area under the point-of-view of medical doctors as agents who make this system of relations between disease and technology. The necessity for public and private planning to deal with this set of problems can benefit through an initial evaluation about the forthcoming theme, but should incorporate the agenda of health and technology planning for the following years. Using mixed methodology, made up of qualitative and quantitative approach, this research sought to reveal and configure important dimensions around the theme of this study. The field research was made up of interviews analyzed using techniques of fundamental theory and also of questionnaires sent by web analyzed statistically using exploratory factor analysis. These ventures allowed dimensions to be revealed that make up the perception of chronic disease and the use of nuclear technology. These dimensions presented in a form of a theoretical construct that were then discussed under the point of view of social theory and technological innovation. (author)

  15. Measuring the Environmental Burden of Disease in South Korea: A Population-Based Study

    Seok-Jun Yoon

    2015-07-01

    Full Text Available Background: This study attempted to measure the environmental burden of disease by examining mortality and disability rates in South Korea, permitting international comparisons. Methods: Disability-adjusted life years (DALY was used to analyze data from public records. Years of life lost (YLL and years lost to disability (YLD were measured in terms of incidence rate and number of deaths. Attributable risks were based on those for WHO Western Pacific Regions. For air pollution, attributable risk was calculated using local PM10 levels and relative risk. Results: The total Korean environmental burden of disease was 17.98 per 1000 persons and the most serious risk factor was air pollution, at 6.89per1000 persons. Occupation was the second highest contributing factor, at 3.29 per 1000 persons, followed by indoor air pollution at 2.91 per 1000 persons. The DALY of air-pollution (indoor and outdoor was 9.80 per 1000 persons, accounting for more than half of the total environmental burden of disease. The burden of chronic obstructive pulmonary disease, lung cancer, and asthma were 4.07, 3.16, and 1.96 per 1000 persons, respectively. Conclusions: Respiratory illnesses comprised most of the disease burden, the majority of which was linked to air pollution. The present results are important as they could be used to make evidence-based decisions regarding the management of diseases and environmental-risk factors.

  16. The association between periodontal disease and peritonsillar infection: a prospective study

    Georgalas, Christos; Kanagalingam, Jeeve; Zainal, Azida; Ahmed, Hamid; Singh, Arvind; Patel, Kalpesh S.

    2002-01-01

    OBJECTIVE: To study the relationship between periodontal status and peritonsillar disease/recurrent tonsillitis. STUDY DESIGN AND SETTING: A total of 158 patients presenting over a 3-year period with peritonsillar abscess (PTA) confirmed by needle aspiration and a control group of 112 patients

  17. Associations between subjective happiness and dry eye disease: a new perspective from the Osaka study.

    Kawashima, Motoko; Uchino, Miki; Yokoi, Norihiko; Uchino, Yuichi; Dogru, Murat; Komuro, Aoi; Sonomura, Yukiko; Kato, Hiroaki; Kinoshita, Shigeru; Mimura, Masaru; Tsubota, Kazuo

    2015-01-01

    Dry eye disease has become an important health problem. A lack of concordance between self-reported symptoms and the outcome of dry eye examinations has raised questions about dry eye disease. To explore the association between subjective happiness and objective and subjective symptoms of dry eye disease. The study adopted a cross-sectional design. All the employees of a company in Osaka, Japan. 672 Japanese office workers using Visual Display Terminals (age range: 26-64 years). The dry eye measurement tools included the Schirmer test, conjunctivocorneal staining, the tear film break-up time, as well as the administration of a dry eye symptoms questionnaire. Happiness was measured by the Subjective Happiness Scale. Dry eye examination parameters, dry eye symptoms questionnaires, and the Subjective Happiness Scale score. Of the 672 workers, 561 (83.5%) completed the questionnaires and examinations. The mean Subjective Happiness Scale score was 4.91 (SD = 1.01). This score was inversely correlated with the dry eye symptom score (r = -0.188, p happiness was the lowest in the group without objective results, but reported subjective symptoms of dry eyes (p happiness and self-reported symptoms of dry eyes. Findings of this study revealed a new perspective on dry eye disease, including the potential for innovative treatments of a specific population with dry eye disease.

  18. CSF biomarkers associated with disease heterogeneity in early Parkinson’s disease: the Parkinson’s Progression Markers Initiative study

    Kang, Ju-Hee; Mollenhauer, Brit; Coffey, Christopher S.; Toledo, Jon B.; Weintraub, Daniel; Galasko, Douglas R.; Irwin, David J.; Van Deerlin, Vivianna; Chen-Plotkin, Alice S.; Caspell-Garcia, Chelsea; Waligórska, Teresa; Taylor, Peggy; Shah, Nirali; Pan, Sarah; Zero, Pawel; Frasier, Mark; Marek, Kenneth; Kieburtz, Karl; Jennings, Danna; Tanner, Caroline M.; Simuni, Tanya; Singleton, Andrew; Toga, Arthur W.; Chowdhury, Sohini; Trojanowski, John Q.; Shaw, Leslie M.

    2016-01-01

    The development of biomarkers to predict the progression of Parkinson’s disease (PD) from its earliest stage through its heterogeneous course is critical for research and therapeutic development. The Parkinson’s Progression Markers Initiative (PPMI) study is an ongoing international multicenter, prospective study to validate biomarkers in drug-naïve PD patients and matched healthy controls (HC). We quantified cerebrospinal fluid (CSF) alpha-synuclein (α-syn), amyloid-beta1–42 (Aβ1–42), total tau (t-tau), and tau phosphorylated at Thr181 (p-tau) in 660 PPMI subjects at baseline, and correlated these data with measures of the clinical features of these subjects. We found that CSF α-syn, t-tau and p-tau levels, but not Aβ1–42, were significantly lower in PD compared with HC, while the diagnostic value of the individual CSF biomarkers for PD diagnosis was limited due to large overlap. The level of α-syn, but not other biomarkers, was significantly lower in PD patients with non-tremor-dominant phenotype compared with tremor-dominant phenotype. In addition, in PD patients the lowest Aβ1–42, or highest t-tau/Aβ1–42 and t-tau/α-syn quintile in PD patients were associated with more severe non-motor dysfunction compared with the highest or lowest quintiles, respectively. In a multivariate regression model, lower α-syn was significantly associated with worse cognitive test performance. APOE ε4 genotype was associated with lower levels of Aβ1–42, but neither with PD diagnosis nor cognition. Our data suggest that the measurement of CSF biomarkers in early-stage PD patients may relate to disease heterogeneity seen in PD. Longitudinal observations in PPMI subjects are needed to define their prognostic performance. PMID:27021906

  19. An electron microscopic study of clinical Paget's disease of the nipple

    Jahn, H; Osther, P J; Nielsen, E H

    1995-01-01

    An ultrastructural study of the epidermis from eight patients with clinical Paget's disease of the nipple supports the epidermotropic theory. There was no evidence that the Paget's cells originated from keratinocytes. We propose the hypothesis that Paget's cells represent transformed ductal cells...

  20. Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study.

    Kikui, Miki; Kokubo, Yoshihiro; Ono, Takahiro; Kida, Momoyo; Kosaka, Takayuki; Yamamoto, Masaaki; Watanabe, Makoto; Maeda, Yoshinobu; Miyamoto, Yoshihiro

    2017-05-01

    A positive association between metabolic syndrome (MetS) and periodontal status has recently been noted. However, no study has evaluated the relationship by sex and in a general urban population using the uniform definition proposed in the 2009 Joint Interim Statement. The aim of this study was to clarify the relationship between MetS and periodontal status using the uniform definition in a general urban Japanese population. A total of 1,856 Japanese men and women (mean age: 66.4 years) were studied using data from the Suita study. Periodontal status was evaluated by the Community Periodontal Index (CPI). MetS was defined using the 2009 Joint Interim Statement. The associations of the MetS and its components with periodontal disease were investigated using multiple logistic regression analysis adjusting for age, drinking, and smoking. Among the components of the MetS, low HDL cholesterol level was significantly associated with periodontal disease in men and women [odds ratios (OR)=2.39 and 1.53; 95% confidence intervals=1.36-4.19 and 1.06-2.19]. Furthermore, the risk of periodontal disease showed 1.43-, 1.42-, and 1.89-fold increases in those with 2, 3, and ≥4 components, respectively, compared with those having no components (P trend <0.001). For the analysis by sex, the risk of periodontal disease was increased 2.27- and 1.76-fold in those with ≥4 components in men and women, respectively (both P trend =0.001). These findings suggest that MetS and lower HDL cholesterol are associated with periodontal disease. Subjects with two or more MetS components had a significantly higher prevalence of periodontal disease.

  1. The hTH-GFP reporter rat model for the study of Parkinson's disease.

    Lorraine Iacovitti

    Full Text Available Parkinson disease (PD is the second leading neurodegenerative disease in the US. As there is no known cause or cure for PD, researchers continue to investigate disease mechanisms and potential new therapies in cell culture and in animal models of PD. In PD, one of the most profoundly affected neuronal populations is the tyrosine hydroxylase (TH-expressing dopaminergic (DA neurons of the substantia nigra pars compacta (SNpc. These DA-producing neurons undergo degeneration while neighboring DA-producing cells of the ventral tegmental area (VTA are largely spared. To aid in these studies, The Michael J. Fox Foundation (MJFF partnered with Thomas Jefferson University and Taconic Inc. to generate new transgenic rat lines carrying the human TH gene promoter driving EGFP using a 11 kb construct used previously to create a hTH-GFP mouse reporter line. Of the five rat founder lines that were generated, three exhibited high level specific GFP fluorescence in DA brain structures (ie. SN, VTA, striatum, olfactory bulb, hypothalamus. As with the hTH-GFP mouse, none of the rat lines exhibit reporter expression in adrenergic structures like the adrenal gland. Line 12141, with its high levels of GFP in adult DA brain structures and minimal ectopic GFP expression in non-DA structures, was characterized in detail. We show here that this line allows for anatomical visualization and microdissection of the rat midbrain into SNpc and/or VTA, enabling detailed analysis of midbrain DA neurons and axonal projections after toxin treatment in vivo. Moreover, we further show that embryonic SNpc and/or VTA neurons, enriched by microdissection or FACS, can be used in culture or transplant studies of PD. Thus, the hTH-GFP reporter rat should be a valuable tool for Parkinson's disease research.

  2. Hemoglobin and hematocrit levels in the prediction of complicated Crohn's disease behavior--a cohort study.

    Rieder, Florian; Paul, Gisela; Schnoy, Elisabeth; Schleder, Stephan; Wolf, Alexandra; Kamm, Florian; Dirmeier, Andrea; Strauch, Ulrike; Obermeier, Florian; Lopez, Rocio; Achkar, Jean-Paul; Rogler, Gerhard; Klebl, Frank

    2014-01-01

    Markers that predict the occurrence of a complicated disease behavior in patients with Crohn's disease (CD) can permit a more aggressive therapeutic regimen for patients at risk. The aim of this cohort study was to test the blood levels of hemoglobin (Hgb) and hematocrit (Hct) for the prediction of complicated CD behavior and CD related surgery in an adult patient population. Blood samples of 62 CD patients of the German Inflammatory Bowel Disease-network "Kompetenznetz CED" were tested for the levels of Hgb and Hct prior to the occurrence of complicated disease behavior or CD related surgery. The relation of these markers and clinical events was studied using Kaplan-Meier survival analysis and adjusted COX-proportional hazard regression models. The median follow-up time was 55.8 months. Of the 62 CD patients without any previous complication or surgery 34% developed a complication and/or underwent CD related surgery. Low Hgb or Hct levels were independent predictors of a shorter time to occurrence of the first complication or CD related surgery. This was true for early as well as late occurring complications. Stable low Hgb or Hct during serial follow-up measurements had a higher frequency of complications compared to patients with a stable normal Hgb or Hct, respectively. Determination of Hgb or Hct in complication and surgery naïve CD patients might serve as an additional tool for the prediction of complicated disease behavior.

  3. Determining the optimal approach to identifying individuals with chronic obstructive pulmonary disease: The DOC study.

    Ronaldson, Sarah J; Dyson, Lisa; Clark, Laura; Hewitt, Catherine E; Torgerson, David J; Cooper, Brendan G; Kearney, Matt; Laughey, William; Raghunath, Raghu; Steele, Lisa; Rhodes, Rebecca; Adamson, Joy

    2018-06-01

    Early identification of chronic obstructive pulmonary disease (COPD) results in patients receiving appropriate management for their condition at an earlier stage in their disease. The determining the optimal approach to identifying individuals with chronic obstructive pulmonary disease (DOC) study was a case-finding study to enhance early identification of COPD in primary care, which evaluated the diagnostic accuracy of a series of simple lung function tests and symptom-based case-finding questionnaires. Current smokers aged 35 or more were invited to undertake a series of case-finding tools, which comprised lung function tests (specifically, spirometry, microspirometry, peak flow meter, and WheezoMeter) and several case-finding questionnaires. The effectiveness of these tests, individually or in combination, to identify small airways obstruction was evaluated against the gold standard of spirometry, with the quality of spirometry tests assessed by independent overreaders. The study was conducted with general practices in the Yorkshire and Humberside area, in the UK. Six hundred eighty-one individuals met the inclusion criteria, with 444 participants completing their study appointments. A total of 216 (49%) with good-quality spirometry readings were included in the analysis. The most effective case-finding tools were found to be the peak flow meter alone, the peak flow meter plus WheezoMeter, and microspirometry alone. In addition to the main analysis, where the severity of airflow obstruction was based on fixed ratios and percent of predicted values, sensitivity analyses were conducted by using lower limit of normal values. This research informs the choice of test for COPD identification; case-finding by use of the peak flow meter or microspirometer could be used routinely in primary care for suspected COPD patients. Only those testing positive to these tests would move on to full spirometry, thereby reducing unnecessary spirometric testing. © 2018 John Wiley

  4. The burden of acute disease in Mahajanga, Madagascar - a 21 month study.

    Vijay C Kannan

    Full Text Available Efforts to develop effective and regionally-appropriate emergency care systems in sub-Saharan Africa are hindered by a lack of data on both the burden of disease in the region and on the state of existing care delivery mechanisms. This study describes the burden of acute disease presenting to an emergency unit in Mahajanga, Madagascar.Handwritten patient registries on all emergency department patients presenting between 1 January 2011 and 30 September 2012 were reviewed and data entered into a database. Data included age, sex, diagnosis, and disposition. We classified diagnoses into Clinical Classifications Software (CCS multi-level categories. The population was 53.5% male, with a median age of 31 years. The five most common presenting conditions were 1 Superficial injury; contusion, 2 Open wounds of head; neck; and trunk, 3 Open wounds of extremities, 4 Intracranial injury, and 5 Unspecified injury and poisoning. Trauma accounted for 48%, Infectious Disease for 15%, Mental Health 6.1%, Noncommunicable 29%, and Neoplasms 1.2%. The acuity seen was high, with an admission rate of 43%. Trauma was the most common reason for admission, representing 19% of admitted patients.This study describes the burden of acute disease at a large referral center in northern Madagascar. The Centre Hôpitalier Universitaire de Mahajanga sees a high volume of acutely ill and injured patients. Similar to other reports from the region, trauma is the most common pathology observed, though infectious disease was responsible for the majority of adult mortality. Typhoid fever other intestinal infections were the most lethal CCS-coded pathologies. By utilizing a widely understood classification system, we are able to highlight contrasts between Mahajanga's acute and overall disease burden as well as make comparisons between this region and the rest of the globe. We hope this study will serve to guide the development of context-appropriate emergency medicine systems in the

  5. The Rabbit as a Model for Studying Lung Disease and Stem Cell Therapy

    Nurfatin Asyikhin Kamaruzaman

    2013-01-01

    Full Text Available No single animal model can reproduce all of the human features of both acute and chronic lung diseases. However, the rabbit is a reliable model and clinically relevant facsimile of human disease. The similarities between rabbits and humans in terms of airway anatomy and responses to inflammatory mediators highlight the value of this species in the investigation of lung disease pathophysiology and in the development of therapeutic agents. The inflammatory responses shown by the rabbit model, especially in the case of asthma, are comparable with those that occur in humans. The allergic rabbit model has been used extensively in drug screening tests, and this model and humans appear to be sensitive to similar drugs. In addition, recent studies have shown that the rabbit serves as a good platform for cell delivery for the purpose of stem-cell-based therapy.

  6. Patients Attitude towards Surgeons Attire in Our Lady of Lourdes Hospital Drogheda

    Babak Meshkat

    2015-04-01

    Full Text Available Background A doctor’s competence and professionalism is often judged on the basis of attire. Our Lady of Lourdes (OLOL is a leading Irish hospital in the implementation of Bare Below the Elbows (BBTE policy, however surgical attire is not standardised and there is great variability in attire worn on wards. We aimed to evaluate patients attitude towards surgeons attire in OLOL. Methods A prospective survey of adult surgical in-patients was conducted from October 2013 to February 2014. A twelve-question questionnaire was used as data collection tool, using a five point Likert scale to assess patients response to each question. Data were collected on patient demographics, patients level of trust and confidence based on different surgical attire, and patients perception of different attire worn by surgical teams. Results There were 150 completed surveys during the study period with a male to female ratio of 44% to 56% respectively. The mean patient length of in-hospital stay (LOS was 4.7 days (range 1–22. The most commonly represented age group was 30–40 years (18%, with a comparable spread among all age groups. The majority of patients found the attire worn by surgeons on the ward to be very appropriate (93%. Majority of responders believed scrubs to be the most appropriate attire for surgeons on wards (39%, followed by shirt and tie with white coat (38% followed by short sleeved shirt and no tie (18%. Shirt and tie with white coat had a positive effect on patients trust in 63% of responders, a negative effect in 10% and no effect in 26%. Scrubs had a positive effect on patients trust in 63%, negative effect in 11% and no effect in 25%. Short sleeved shirt and no tie had a positive effect in 44%, negative effect in 25% and no effect in 30% of patients. Conclusion Patients in OLOL find attire worn by surgeons to be appropriate. Shirt and tie with white coat or scrubs remains the patient’s choice attire for surgeons. Shirt and tie with white

  7. The Nun Study and Alzheimer's disease: Quality of vocation as a potential protective factor?

    Keohane, Kieran; Balfe, Myles

    2017-01-01

    Data from the Nun Study, the most famous longitudinal epidemiology of Alzheimer's disease to date, are analyzed and reformulated in terms of Max Weber's discussion of the centrality of beruf - "calling" - fulfilling a life task in pursuit of a vocation. Qualitative differences in the Nuns' vocations are uncovered, which are correlated to their resilience to dementia. Extrapolating, we argue that Alzheimer's disease and the dementia reputed to it should be understood as a social pathology of contemporary civilization related to the loss of moral foundations from which coherent, meaningful life-projects can be conducted.

  8. The effects of high intensity interval training in women with rheumatic disease: a pilot study.

    Sandstad, Janne; Stensvold, Dorthe; Hoff, Mari; Nes, Bjarne M; Arbo, Ingerid; Bye, Anja

    2015-10-01

    Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are inflammatory diseases which involve increased risk of cardiovascular disease (CVD). High intensity interval training (HIIT) is known to be effective in improving cardiovascular health. The aim of this study was to investigate whether 10 weeks of HIIT at 85-95% of HRmax would improve important risk factors of CVD in rheumatic patients, and if these patients would tolerate exercise intensities above today's recommendations. Seven women with RA and eleven with adult-JIA, 20-50 years, were recruited to this cross-over study. Participants performed HIIT, consisting of 4 × 4 min intervals at 85-95% of HRmax twice a week for 10 weeks on spinning bikes. Maximal oxygen uptake (VO2max), heart rate recovery, blood pressure, body composition, and blood variables were measured before and after the exercise and control period. Disease activity was determined and questionnaire data were collected. HIIT resulted in 12.2% increase in VO2max and 2.9% improvement in heart rate recovery (p HIIT (p = 0.08). No changes were detected in disease activity or pain. Despite rigorous high intensity exercise, no increase was detected in disease activity or pain, indicating that HIIT was well tolerated by these patients. Furthermore, HIIT had positive effects on several CVD risk factors. In light of this pilot study, HIIT seems like a promising non-pharmacological treatment strategy for patients with RA and adult-JIA.

  9. Design of a population-based study of visual impairment in India : The Andhra Pradesh eye disease study

    Dandona Rakhi

    1997-01-01

    Full Text Available Reliable population-based epidemiologic data regarding vision and ocular morbidity, as well as those about the perceptions of people regarding visual impairment and eye care, are lacking for the most part in the developing world including India. These data are the basis on which effective eye care services can be developed. To meet this need we designed the Andhra Pradesh Eye Disease Study, a population-based epidemiology study of 10,000 people in the Indian state of Andhra Pradesh. The design of this study is described in this paper. Various options for the sample size, study areas, sampling procedure, and recruitment of subjects were considered. A sample size of 10,000 people, 5,000 each in the < or = 30 and > 30 years age groups, was determined to obtain reasonable confidence in estimating the prevalence of diseases and odds ratios for risk factors of interest. A multistage sampling strategy was chosen for the study which was assumed to give a design effect of 1.5 for the estimates. One urban area, Hyderabad, and three rural areas, West Godavari, Adilabad and Mahbubnagar districts, were selected in Andhra Pradesh. Interview instruments were developed to obtain detailed information about demographic data, diet, ocular and systemic history, risk factors for eye diseases, visual function, quality of life, barriers to eye care, and knowledge about eye diseases. A detailed examination procedure was devised to obtain a broad range of normative and abnormal data related to eyes and vision. A protocol was developed for doing automated visual fields, slitlamp and fundus photography. Computer databases were made in FoxPro for data entry and subsequent analysis with SPSS. Pilot studies were done to test the instruments, procedures, and logistics of the study in urban and rural areas. Information from the Andhra Pradesh Eye Disease Study is expected to help in planning and implementation of effective long-term preventive, curative, and

  10. An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy.

    Ahmed, Farah; Baloch, Qamaruddin; Memon, Zahid Ali; Ali, Iqra

    2017-05-01

    Recognition of Non alcoholic fatty liver disease (NAFLD) and metabolic syndrome in patients with gallstones undergoing laparoscopic or open cholecystectomy, along with it we will also study the life style of patients with gall stones. Patients with gallstones have associated NAFLD, with concurrent metabolic syndrome and these ailments share similar factors for example obesity, hypertriglyceridemia and diabetes mellitus. Factors like body mass index, gender, raised lipid levels, use of contraceptives and alcohol and having diabetes, physical inactiveness, multiparous women, water with excessive iron content, metabolic syndrome, and NAFLD are accountable factors for gallstones formation. This was a case series done at Surgical Unit 1 of Civil Hospital Karachi. Selective samples of 88 patients were included. Duration was 3 months. We included both sexes with ultrasound proof of gall stone irrespective of cholecystitis. Excluded patients with history of seropositive viral hepatitis, autoimmune and wilson's disease. As these conditions can act as a confounder to our variables. Nafld was present in 62.5%(n = 55) while 28.4% (n = 25) had metabolic syndrome. 26.94% had BMI less than 18, 32.12 had BMI between 18 and 25 and majority had BMI greater than 25 i.e in 40.93%. Of all 46.6% had a family history of cholelithiasis. Gallstone patients with NAFLD reported about their first degree relative being suffering from cholelithiasis at a significant p-value of 0.034 while this was not significant in cases of metabolic syndrome and the p -value was 0.190. We found association of metabolic syndrome with gallstones and NAFLD. Non alcoholic fatty liver was highly prevalent in our study subjects. Huge percentage of first degree relatives of gall stone patients had gallstones and this relation was more pronounced patients who had associated NAFLD.

  11. Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: the EURODIAB prospective complications study

    van Hecke, M.V.; Dekker, J.M.; Stehouwer, C.D.A.; Polak, B.C.P.; Fuller, J.H.; Sjolie, A.K.; Kofinis, A.; Rottiers, R.; Porta, M.; Chaturvedi, N.

    2005-01-01

    OBJECTIVE - To study the relationship of nonproliferative and proliferative retinopathy with all-cause mortality and cardiovascular disease (CVD) incidence in type 1 diabetic patients and, additionally, the role of cardiovascular risk factors in these associations. RESEARCH DESIGN AND METHODS - This

  12. Dietary fat and cholesterol and risk of cardiovascular disease in older adults: The Health ABC Study

    Houston, D.K.; Ding, J.; Lee, J.S.; Garcia, M.; Kanaya, A.; Tylavsky, F.A.; Newman, A.B.; Visser, M.; Kritchevsky, S.B.

    2011-01-01

    Background and aims: Although dietary fats and cholesterol have previously been associated with risk of cardiovascular disease (CVD) in middle-aged populations, less is known among older adults. The purpose of this study was to determine the association between dietary fats, cholesterol, and eggs

  13. Cardiovascular disease risk factors in persons with paraplegia: the Stockholm spinal cord injury study.

    Wahman, Kerstin; Nash, Mark S; Westgren, Ninni; Lewis, John E; Seiger, Ake; Levi, Richard

    2010-03-01

    To examine cardiovascular disease risk factors and risk clusters in Swedish persons with traumatic wheelchair-dependent paraplegia. Prospective examination. A total of 135 individuals aged 18-79 years with chronic (>or= 1 year) post-traumatic paraplegia. Cardiovascular disease risk factors; dyslipidemia, impaired fasting glucose, hypertension, overweight, smoking, and medication usage for dyslipidemia, hypertension, and diabetes mellitus, were analyzed according to authoritative guidelines. Stepwise regression tested the effects of age, gender, and injury characteristics on cardiovascular disease risks. High-prevalence risk factors were dyslipidemia (83.1%), hypertension (39.3%), and overweight (42.2%) with pervasive clustering of these risks. Being older was related to increased cardiovascular disease risk, except for dyslipidemia. Hypertension was more common in low-level paraplegia. Prevalence of impaired fasting glucose was lower than previously reported after paraplegia. A high percentage of persons being prescribed drug treatment for dyslipidemia and hypertension failed to reach authoritative targets for cardiovascular disease risk reduction. Swedish persons with paraplegia are at high risk for dyslipidemia, hypertension, and overweight. Impaired fasting glucose was not as common as reported in some previous studies. Pharmacotherapy for dyslipidemia and hypertension often failed to achieve recommended targets. Population-based screening and therapeutic countermeasures to these cardiovascular disease risks are indicated.

  14. The central biobank and virtual biobank of BIOMARKAPD: a resource for studies on neurodegenerative diseases

    Babette eReijs

    2015-10-01

    Full Text Available AbstractBiobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's Disease (BIOMARKAPD is a European multicenter study, funded by the EU Joint Programme - Neurodegenerative Disease Research (JPND, that aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer’s disease (AD and Parkinson’s disease (PD. The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF and blood samples were collected according to the BIOMARKAPD standardized preanalytical procedures (SOP and stored at Integrated BioBank of Luxembourg (IBBL. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI, AD, frontotemporal dementia (FTD, vascular dementia (VaD, multiple system atrophy (MSA, progressive supranuclear palsy (PSP, PD, PD with dementia, and dementia with Lewy bodies (DLB. The virtual biobank contains information on over 8600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.

  15. Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol

    van der Vlugt Maureen J

    2011-02-01

    Full Text Available Abstract Background Cerebral small vessel disease (SVD is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects with SVD become demented or get parkinsonism. This might be explained by the diversity of underlying pathology of both white matter lesions (WML and the normal appearing white matter (NAWM. Both cannot be properly appreciated with conventional MRI. Diffusion tensor imaging (DTI provides alternative information on microstructural white matter integrity. The association between SVD, its microstructural integrity, and incident dementia and parkinsonism has never been investigated. Methods/Design The RUN DMC study is a prospective cohort study on the risk factors and cognitive and motor consequences of brain changes among 503 non-demented elderly, aged between 50-85 years, with cerebral SVD. First follow up is being prepared for July 2011. Participants alive will be included and invited to the research centre to undergo a structured questionnaire on demographics and vascular risk factors, and a cognitive, and motor, assessment, followed by a MRI protocol including conventional MRI, DTI and resting state fMRI. Discussion The follow up of the RUN DMC study has the potential to further unravel the causes and possibly better predict the consequences of changes in white matter integrity in elderly with SVD by using relatively new imaging techniques. When proven, these changes might function as a surrogate endpoint for cognitive and motor function in future therapeutic trials. Our data could furthermore provide a better understanding of the pathophysiology of cognitive and motor disturbances in elderly with SVD. The execution and completion of the follow up of our study might ultimately unravel the role of SVD on the microstructural integrity of the white

  16. Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol.

    van Norden, Anouk Gw; de Laat, Karlijn F; Gons, Rob Ar; van Uden, Inge Wm; van Dijk, Ewoud J; van Oudheusden, Lucas Jb; Esselink, Rianne Aj; Bloem, Bastiaan R; van Engelen, Baziel Gm; Zwarts, Machiel J; Tendolkar, Indira; Olde-Rikkert, Marcel G; van der Vlugt, Maureen J; Zwiers, Marcel P; Norris, David G; de Leeuw, Frank-Erik

    2011-02-28

    Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects with SVD become demented or get parkinsonism. This might be explained by the diversity of underlying pathology of both white matter lesions (WML) and the normal appearing white matter (NAWM). Both cannot be properly appreciated with conventional MRI. Diffusion tensor imaging (DTI) provides alternative information on microstructural white matter integrity. The association between SVD, its microstructural integrity, and incident dementia and parkinsonism has never been investigated. The RUN DMC study is a prospective cohort study on the risk factors and cognitive and motor consequences of brain changes among 503 non-demented elderly, aged between 50-85 years, with cerebral SVD. First follow up is being prepared for July 2011. Participants alive will be included and invited to the research centre to undergo a structured questionnaire on demographics and vascular risk factors, and a cognitive, and motor, assessment, followed by a MRI protocol including conventional MRI, DTI and resting state fMRI. The follow up of the RUN DMC study has the potential to further unravel the causes and possibly better predict the consequences of changes in white matter integrity in elderly with SVD by using relatively new imaging techniques. When proven, these changes might function as a surrogate endpoint for cognitive and motor function in future therapeutic trials. Our data could furthermore provide a better understanding of the pathophysiology of cognitive and motor disturbances in elderly with SVD. The execution and completion of the follow up of our study might ultimately unravel the role of SVD on the microstructural integrity of the white matter in the transition from "normal" aging to cognitive and

  17. Psychosocial work environment and risk of ischaemic heart disease in women: the Danish Nurse Cohort Study

    Allesøe, Karen; Hundrup, Yrsa Andersen; Thomsen, Jane Frølund

    2010-01-01

    OBJECTIVES: To investigate the effect of work pressure and job influence on the development of ischaemic heart disease (IHD) in women. METHODS: The effect of work pressure and job influence on the 15-year incidence of IHD in women participating in the Danish Nurse Cohort Study was prospectively s......: In this study we find that work pressure that is too high is a significant risk factor for IHD in younger female employees (

  18. Study on the changes of serum HA and CG levels in several diseases besides liver disorders

    Lu Zhiping; Ma Yunbao; Zhang Xiaoyi; Lv Weihua

    2005-01-01

    Objective: To study the changes of serum hyaluronic acid (HA) and cholyglycine (CG) in several diseases besides liver disorders. Methods: Serum HA and CG levels were measured with RIA in 78 patients with chronic liver diseases (with 70 controls), (84 patients with primary hepatic carcinoma ), 70 pediatric patients with various infections diseases (with 40 controls), 50 pediatric patients with recurrent respiratory infection (RRI, with 30 controls) and 428 pregnant women ( with 60 controls). In addition, RBC C 3 b receptor ratio (RBCC 3 bRR) and RBC immune-complex ratio (RBCICR) (both with yeast rosette method) as well as serum IgG,IgM,IgA,C 3 levels (with immunoturbidity test) were examined in the 50 RRI pediatric patients, ALT levels were examined in the 70 pediatric patients with infectious diseases and SF examined in the 78 patients with chronic liver diseases. Results: The serum CG, HA and SF levels in the three groups of patients with chronic liver diseases ( CPH, CAH, Cirrhosis) were significantly higher than those in the controls (all P 0.05). In patients with hepatic carcinoma, the CG and HA levels were positively correlated with the mortality at 4 months (P 0.05). For ALT, levels only increased in patients with hepatitis and typhoid fever with none in bacillary dysentery and mumps. In pediatric patients with RRI, RBCC 3 bRR (%), CG, C 3 , IgG levels were significantly higher than those in controls (P 0.05). Conclusion: Various infectious diseases in pediatric patients could induce mild liver damage, which was closely related to the depressed immune status. High CG and HA levels in liver cancer patients suggested high mortality at 4 months. Women in late pregnancy might harbour disturbances in CG metabolism and mild liver injury though without overt symptoms. (authors)

  19. Comparative assessment of the prevalence of periodontal disease in subjects with and without systemic autoimmune diseases: A case-control study.

    Ramesh Kumar, S G; Aswath Narayanan, M B; Jayanthi, D

    2016-01-01

    Immune mechanism shares a common pathway both for systemic autoimmune diseases and periodontal diseases. Scientific exploration of literature revealed limited studies on the association between systemic autoimmune diseases and periodontal diseases in India. The aim of the study is to find whether the presence of systemic autoimmune diseases in an individual is a risk factor for the development of periodontal disease. This was a hospital-based case-control study. A sample of 253 patients with systemic autoimmune diseases, attending the Rheumatology Department of Government General Hospital, Chennai-3, and 262 patients without systemic autoimmune diseases, attending the outpatient department of the Tamil Nadu Government Dental College and Hospital, Chennai-3, constituted the case and control groups, respectively. Age, gender, and oral hygiene status matching was done. Oral hygiene status was assessed using oral hygiene index (OHI) and periodontal status was assessed using community periodontal index (CPI) and loss of attachment (LOA) index. Statistical analysis was done using SPSS version 15 (SPSS Inc, 2006, Chicago). Results showed 99.2% and 73.9% prevalence of gingivitis and periodontitis, respectively, in the case group as compared to 85.5% and 14.9%, respectively, in the control group. There is no linear relationship between OHI scores and prevalence of periodontitis (CPI and LOA scores) in the case group. Patients suffering from systemic autoimmune diseases showed more prevalence of periodontal diseases irrespective of oral hygiene scores. It is postulated that the presence of systemic autoimmune diseases may pose a risk for the development of periodontal diseases.

  20. The RUDY study platform – a novel approach to patient driven research in rare musculoskeletal diseases

    M. K. Javaid

    2016-11-01

    Full Text Available Abstract Background Research into rare diseases is becoming more common, with recognition of the significant diagnostic and therapeutic care gaps. Registries are considered a key research methodology to address rare diseases. This report describes the structure of the Rare UK Diseases Study (RUDY platform that aims to improve research processes and address many of the challenges of carrying out rare musculoskeletal disease research. RUDY is an internet-based platform with online registration, initial verbal consent, online capture of patient reported outcome measures and events within a dynamic consent framework. The database structure, security and governance framework are described. Results There have been 380 participants recruited into RUDY with completed questionnaire rates in excess of 50 %. There has been one withdrawal and two participants have amended their consent options. Conclusions The strengths of RUDY include low burden for the clinical team, low research administration costs with high participant recruitment and ease of data collection and access. This platform has the potential to be used as the model for other rare diseases globally.

  1. Quality of care of treatment for uncomplicated severe acute malnutrition provided by lady health workers in Pakistan.

    Rogers, Eleanor; Ali, Muhammad; Fazal, Shahid; Kumar, Deepak; Guerrero, Saul; Hussain, Imtiaz; Soofi, Sajid; Alvarez Morán, Jose Luis

    2018-02-01

    To assess the quality of care provided by lady health workers (LHW) managing cases of uncomplicated severe acute malnutrition (SAM) in the community. Cross-sectional quality-of-care study. The feasibility of the implementation of screening and treatment for uncomplicated SAM in the community by LHW was tested in Sindh Province, Pakistan. An observational, clinical prospective multicentre cohort study compared the LHW-delivered care with the existing outpatient health facility model. LHW implementing treatment for uncomplicated SAM in the community. Oedema was diagnosed conducted correctly for 87·5 % of children; weight and mid upper-arm circumference were measured correctly for 60·0 % and 57·4 % of children, respectively. The appetite test was conducted correctly for 42·0 % of cases. Of all cases of SAM without complications assessed during the study, 68·0 % received the correct medical and nutrition treatment. The proportion of cases that received the correct medical and nutrition treatment and key counselling messages was 4·0 %. This quality-of-care study supports existing evidence that LHW are able to identify uncomplicated SAM, and a majority can provide appropriate nutrition and medical treatment in the community. However, the findings also show that their ability to provide the complete package with an acceptable level of care is not assured. Additional evidence on the impact of supervision and training on the quality of SAM treatment and counselling provided by LHW to children with SAM is required. The study has also shown that, as in other sectors, it is essential that operational challenges are addressed in a timely manner and that implementers receive appropriate levels of support, if SAM is to be treated successfully in the community.

  2. A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease.

    Eirini Kalliolia

    Full Text Available Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to hypothalamic pathology and dysfunction of hypothalamo-pituitary axes.We studied neuroendocrine profiles of corticotropic, somatotropic and gonadotropic hypothalamo-pituitary axes hormones over a 24-hour period in controlled environment in 15 healthy controls, 14 premanifest and 13 stage II/III Huntington's disease subjects. We also quantified fasting levels of vasopressin, oestradiol, testosterone, dehydroepiandrosterone sulphate, thyroid stimulating hormone, free triiodothyronine, free total thyroxine, prolactin, adrenaline and noradrenaline. Somatotropic axis hormones, growth hormone releasing hormone, insulin-like growth factor-1 and insulin-like factor binding protein-3 were quantified at 06:00 (fasting, 15:00 and 23:00. A battery of clinical tests, including neurological rating and function scales were performed.24-hour concentrations of adrenocorticotropic hormone, cortisol, luteinizing hormone and follicle-stimulating hormone did not differ significantly between the Huntington's disease group and controls. Daytime growth hormone secretion was similar in control and Huntington's disease subjects. Stage II/III Huntington's disease subjects had lower concentration of post-sleep growth hormone pulse and higher insulin-like growth factor-1:growth hormone ratio which did not reach significance. In Huntington's disease subjects, baseline levels of hypothalamo-pituitary axis hormones measured did not significantly differ from those of healthy controls.The relatively small subject group means that the study may not detect subtle perturbations in hormone concentrations. A targeted study of the somatotropic axis in larger cohorts may be warranted. However, the lack of significant results despite many

  3. A Study on the Measurement of Intrapulmonary Shunt in Liver Diseases by the Nucleolide Method

    Yun, Sung Chul; Ahn, Jae Hee; Choi, Soo Bong

    1987-01-01

    The fact there are increase of intrapulmonary arteriovenous shunt amount in the liver cirrhosis patient has been known since 1950. And the method of shunt amount calculation by radionuclide method using 99m Tc-MAA was introduced in the middle of 1970. We measured intrapulmonary shunt amount by means of perfusion lung scan using 99m Tc-MAA in the various type of liver diseases especially in chronic liver diseases and acute liver disease. The results were as followed. 1) The amount of arteriovenous intrapulmonary shunt in the total case of liver disease was 9.3±3.9%, and that of in the control group was 4.6±2.1%. 2) The amount of arteriovenous intrapulmonary shunt in the chronic liver disease was 10.8±4.4%, and that of in the acute liver disease was 7.2±2.8%. We observed significant differences between normal control group and liver disease group, and between chronic liver disease group and acute liver disease group in the amount of shunt by the nucleolide method.

  4. Peripheral arterial disease, gender, and depression in the Heart and Soul Study

    Grenon, S. Marlene; Cohen, Beth E.; Smolderen, Kim; Vittinghoff, Eric; Whooley, Mary A.; Hiramoto, Jade

    2014-01-01

    Background Despite the high prevalence of peripheral arterial disease (PAD) in women, risk factors for PAD in women are not well understood. Methods Gender-specific risk factors for PAD were examined in a prospective cohort study of 1024 patients (184 women and 840 men) with stable coronary artery

  5. Epidemiology of chronic renal disease in the Galician population: results of the pilot Spanish EPIRCE study.

    Otero, Alfonso; Gayoso, Pilar; Garcia, Fernando; de Francisco, Angel L

    2005-12-01

    Chronic kidney disease (CKD) is a major social health problem because of the aging of the population, the high incidence of diabetes mellitus, and the epidemic of silent CKD resulting from inadequate diagnosis of early chronic renal insufficiency The sociodemographic, baseline characteristics and CKD prevalence measured by the Modification of Diet in Renal Disease formula were studied in a randomly selected sample of people aged 20 years or older in the general population. We report the results of the analysis of the EPIRCE (Estudio Epidemiológico de la Insuficiencia Renal en España) pilot study performed in Galicia, Spain, in the last quarter of 2004. Baseline characteristics, sociodemographic characteristics, and results of a clinical examination and blood variables were collected from 237 patients who fulfilled the study's inclusion and exclusion criteria. The mean age of the sample was 49.58 years (95% confidence interval, 47.39-51.76). The prevalence of Kidney Disease Outcomes Quality Initiative grade 3 CKD was 5.1%, but the coexistence of an albumin/creatinine ratio>30 mg/g with grade 1 to 2 CKD raised the final rate to 12.7% in this population. We found a high prevalence of hypertension (31.5%), isolated systolic hypertension (20.1%), diabetes mellitus (8%), obesity (13.1%), smoking habit (22.7%), high atherogenic index (30.8%), and high alcohol intake (24%). Risk factors significantly associated with renal disease were age [P=0.018; odds ratio (OR) 2.7], hypertension (P=0.023; OR 2.13), pulse pressure (P=0.04; OR 0.10), diabetes mellitus (P=0.08; OR 4.48), obesity (P=0.000; OR 7.7), and insulin resistance index (P=0.04; OR 4.95). The prevalence of CKD and conventional cardiovascular risk factors is high in this randomly selected sample of the general population. Secondary preventive measures are needed to detect chronic kidney impairment as early as possible and to reduce the incidence and mortality arising from the associated comorbidities.

  6. Comparative study of collagen deposition in the colon wall of patients operated for sigmoid diverticular disease.

    Pantaroto, Mário; Lopes Filho, Gaspar de Jesus; Pinto, Clovis Antonio Lopes; Antico Filho, Armando

    2015-10-01

    To investigate the deposition of collagen in the colon wall of patients with sigmoid diverticulitis. Samples of sigmoid tissue from 15 patients (disease group), seven men and eight women aged 37-77 years who underwent surgery for the treatment of diverticulitis, were selected. For the control group, specimens from five patients, three men and two women aged 19-58 years undergoing emergency surgery for sigmoid trauma were selected. These subjects had no associated diseases. The histological study of the surgical specimens was performed by staining with hematoxylin-eosin and picrosirius and using a histochemical method for collagen quantification. Collagen deposition in the colon wall in terms of area (F), glandular epithelium (E) and total area was significantly higher in the disease group compared to control (p=0.003, p=0.026 and p=0.010, respectively). The collagen volume fraction (F fraction) and muscle tissue (M fraction) were also significantly higher compared to control (p=0.044 and p=0.026, respectively). The muscle (M area) and volume fraction of glandular epithelium (E fraction) did not differ significantly between the two groups, (p=0.074 and p=1.000, respectively). In this study, collagen deposition in the colon wall of the patients operated for sigmoid diverticulitis was higher compared to patients without the disease.

  7. PubMed search filters for the study of putative outdoor air pollution determinants of disease.

    Curti, Stefania; Gori, Davide; Di Gregori, Valentina; Farioli, Andrea; Baldasseroni, Alberto; Fantini, Maria Pia; Christiani, David C; Violante, Francesco S; Mattioli, Stefano

    2016-12-21

    Several PubMed search filters have been developed in contexts other than environmental. We aimed at identifying efficient PubMed search filters for the study of environmental determinants of diseases related to outdoor air pollution. We compiled a list of Medical Subject Headings (MeSH) and non-MeSH terms seeming pertinent to outdoor air pollutants exposure as determinants of diseases in the general population. We estimated proportions of potentially pertinent articles to formulate two filters (one 'more specific', one 'more sensitive'). Their overall performance was evaluated as compared with our gold standard derived from systematic reviews on diseases potentially related to outdoor air pollution. We tested these filters in the study of three diseases potentially associated with outdoor air pollution and calculated the number of needed to read (NNR) abstracts to identify one potentially pertinent article in the context of these diseases. Last searches were run in January 2016. The 'more specific' filter was based on the combination of terms that yielded a threshold of potentially pertinent articles ≥40%. The 'more sensitive' filter was based on the combination of all search terms under study. When compared with the gold standard, the 'more specific' filter reported the highest specificity (67.4%; with a sensitivity of 82.5%), while the 'more sensitive' one reported the highest sensitivity (98.5%; with a specificity of 47.9%). The NNR to find one potentially pertinent article was 1.9 for the 'more specific' filter and 3.3 for the 'more sensitive' one. The proposed search filters could help healthcare professionals investigate environmental determinants of medical conditions that could be potentially related to outdoor air pollution. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  8. PubMed search filters for the study of putative outdoor air pollution determinants of disease

    Curti, Stefania; Gori, Davide; Di Gregori, Valentina; Farioli, Andrea; Baldasseroni, Alberto; Fantini, Maria Pia; Christiani, David C; Violante, Francesco S; Mattioli, Stefano

    2016-01-01

    Objectives Several PubMed search filters have been developed in contexts other than environmental. We aimed at identifying efficient PubMed search filters for the study of environmental determinants of diseases related to outdoor air pollution. Methods We compiled a list of Medical Subject Headings (MeSH) and non-MeSH terms seeming pertinent to outdoor air pollutants exposure as determinants of diseases in the general population. We estimated proportions of potentially pertinent articles to formulate two filters (one ‘more specific’, one ‘more sensitive’). Their overall performance was evaluated as compared with our gold standard derived from systematic reviews on diseases potentially related to outdoor air pollution. We tested these filters in the study of three diseases potentially associated with outdoor air pollution and calculated the number of needed to read (NNR) abstracts to identify one potentially pertinent article in the context of these diseases. Last searches were run in January 2016. Results The ‘more specific’ filter was based on the combination of terms that yielded a threshold of potentially pertinent articles ≥40%. The ‘more sensitive’ filter was based on the combination of all search terms under study. When compared with the gold standard, the ‘more specific’ filter reported the highest specificity (67.4%; with a sensitivity of 82.5%), while the ‘more sensitive’ one reported the highest sensitivity (98.5%; with a specificity of 47.9%). The NNR to find one potentially pertinent article was 1.9 for the ‘more specific’ filter and 3.3 for the ‘more sensitive’ one. Conclusions The proposed search filters could help healthcare professionals investigate environmental determinants of medical conditions that could be potentially related to outdoor air pollution. PMID:28003291

  9. Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies.

    Kurbasic, Azra; Poveda, Alaitz; Chen, Yan; Agren, Asa; Engberg, Elisabeth; Hu, Frank B; Johansson, Ingegerd; Barroso, Ines; Brändström, Anders; Hallmans, Göran; Renström, Frida; Franks, Paul W

    2014-12-01

    Most complex diseases have well-established genetic and non-genetic risk factors. In some instances, these risk factors are likely to interact, whereby their joint effects convey a level of risk that is either significantly more or less than the sum of these risks. Characterizing these gene-environment interactions may help elucidate the biology of complex diseases, as well as to guide strategies for their targeted prevention. In most cases, the detection of gene-environment interactions will require sample sizes in excess of those needed to detect the marginal effects of the genetic and environmental risk factors. Although many consortia have been formed, comprising multiple diverse cohorts to detect gene-environment interactions, few robust examples of such interactions have been discovered. This may be because combining data across studies, usually through meta-analysis of summary data from the contributing cohorts, is often a statistically inefficient approach for the detection of gene-environment interactions. Ideally, single, very large and well-genotyped prospective cohorts, with validated measures of environmental risk factor and disease outcomes should be used to study interactions. The presence of strong founder effects within those cohorts might further strengthen the capacity to detect novel genetic effects and gene-environment interactions. Access to accurate genealogical data would also aid in studying the diploid nature of the human genome, such as genomic imprinting (parent-of-origin effects). Here we describe two studies from northern Sweden (the GLACIER and VIKING studies) that fulfill these characteristics.

  10. The efficacy of diagnostic battery in Pott′s disease: A prospective study

    Manoj Kumar

    2014-01-01

    Full Text Available Background: The diagnosis of Pott′s disease is mostly based on clinicoradiological observations substantiated by the bacterial culture, staining and histopathology. Since, no single technique is enough to conclude Pott′s disease in diagnosis, the present study was undertaken to correlate the clinicoradiological, microbiological, histopathological and molecular method to evaluate the effectiveness in diagnosis of Pott′s disease. Materials and Methods: 62 clinicoradiologically suspected cases of Pott′s disease were included in this study. The specimens for diagnostic work up were collected either during surgery or by computed tomography guided fine needle aspiration. All these specimens were tested for tuberculosis (TB through Ziehl-Neelsen (ZN microscopy, BACTEC culture, histopathology and polymerase chain reaction (PCR. The final diagnosis was established by the results of performed tests and clinicoradiological improvement of cases at the end of 6 months on anti tubercular treatment. Results: Out of 62 cases, 7 were excluded from this study as these were turned out to be neoplastic lesions on histopathology. Amongst remaining 55 cases, the TB was diagnosed in 39 (71% on histopathology, 37 (67.5% on PCR, 27 (49% on BACTEC culture and 20 (36.3% on ZN microscopy. Ultimately 45 cases were tested as positive and 10 were detected as negative for TB in combination of ZN microscopy, BACTEC culture and histopathology. PCR was positive in 37 of 45 cases and 10/55 cases remained negative. On clinical analysis of these 10 cases, it was noted that these were cases of relapse/poor compliance. The combination of PCR and histopathology was also shown positive for TB in 45 cases. Hence, the PCR showed a fair positive agreement (Κc = 0.63 against the combined results of all performed traditional methods. Conclusions: The combination of PCR and histopathology is a rapid and efficient tool for diagnosis of Pott′s disease.

  11. The LIFE child study: a life course approach to disease and health

    Quante Mirja

    2012-11-01

    Full Text Available Abstract Background Profound knowledge about child growth, development, health, and disease in contemporary children and adolescents is still rare. Epidemiological studies together with new powerful research technologies present exciting opportunities to the elucidation of risk factor-outcome associations with potentially major consequences for prevention, diagnosis and treatment. Aim To conduct a unique prospective longitudinal cohort study in order to assess how environmental, metabolic and genetic factors affect growth, development and health from fetal life to adulthood. Methods The ‘Leipzig Research Centre for Civilization Diseases (LIFE Child Study’ focuses on two main research objectives: (1 monitoring of normal growth, development and health; (2 non-communicable diseases such as childhood obesity and its co-morbidities, atopy and mental health problems. Detailed assessments will be conducted alongside long-term storage of biological samples in 2,000 pregnant women and more than 10,000 children and their families. Results Close coordination and engagement of a multidisciplinary team in the LIFE Child study successfully established procedures and systems for balancing many competing study and ethical needs. Full participant recruitment and complete data collection started in July 2011. Early data indicate a high acceptance rate of the study program, successful recruitment strategies and the establishment of a representative cohort for the population of Leipzig. A series of subprojects are ongoing, and analyses and publications are on their way. Discussion This paper addresses key elements in the design and implementation of the new prospective longitudinal cohort study LIFE Child. Given the recognized need for long-term data on adverse effects on health and protective factors, our study data collection should provide magnificent opportunities to examine complex interactions that govern the emergence of non-communicable diseases.

  12. The LIFE child study: a life course approach to disease and health

    2012-01-01

    Background Profound knowledge about child growth, development, health, and disease in contemporary children and adolescents is still rare. Epidemiological studies together with new powerful research technologies present exciting opportunities to the elucidation of risk factor-outcome associations with potentially major consequences for prevention, diagnosis and treatment. Aim To conduct a unique prospective longitudinal cohort study in order to assess how environmental, metabolic and genetic factors affect growth, development and health from fetal life to adulthood. Methods The ‘Leipzig Research Centre for Civilization Diseases (LIFE) Child Study’ focuses on two main research objectives: (1) monitoring of normal growth, development and health; (2) non-communicable diseases such as childhood obesity and its co-morbidities, atopy and mental health problems. Detailed assessments will be conducted alongside long-term storage of biological samples in 2,000 pregnant women and more than 10,000 children and their families. Results Close coordination and engagement of a multidisciplinary team in the LIFE Child study successfully established procedures and systems for balancing many competing study and ethical needs. Full participant recruitment and complete data collection started in July 2011. Early data indicate a high acceptance rate of the study program, successful recruitment strategies and the establishment of a representative cohort for the population of Leipzig. A series of subprojects are ongoing, and analyses and publications are on their way. Discussion This paper addresses key elements in the design and implementation of the new prospective longitudinal cohort study LIFE Child. Given the recognized need for long-term data on adverse effects on health and protective factors, our study data collection should provide magnificent opportunities to examine complex interactions that govern the emergence of non-communicable diseases. PMID:23181778

  13. Infliximab for Crohn's disease in the Swiss IBD Cohort Study: clinical management and appropriateness.

    Juillerat, Pascal; Pittet, Valérie; Vader, John-Paul; Burnand, Bernard; Gonvers, Jean-Jacques; de Saussure, Philippe; Mottet, Christian; Seibold, Frank; Rogler, Gerhard; Sagmeister, Markus; Felley, Christian; Michetti, Pierre; Froehlich, Florian

    2010-11-01

    Antitumor necrosis factor a agents have significantly improved the management of Crohn's disease (CD), but not all patients benefit from this therapy. We used data from the Swiss Inflammatory Bowel Disease Cohort Study and predefined appropriateness criteria to examine the appropriateness of use of infliximab (IFX) in CD patients. EPACT II (European Panel on the Appropriateness of CD Therapy, 2007; www.epact.ch) appropriateness criteria have been developed using a formal explicit panel process combining evidence from the published literature and expert opinion. Questionnaires relating to EPACT II criteria were used at enrollment and follow-up of all Swiss Inflammatory Bowel Disease Cohort Study patients. A step-by-step analysis of all possible indications for IFX therapy in a given patient allowed identification of the most appropriate indication and final classification in a single appropriateness category (appropriate, uncertain, inappropriate). Eight hundred and twenty-one CD patients were prospectively enrolled between November 2006 and March 2009. IFX was administered to 146 patients (18%) at enrollment and was most frequently used for complex fistulizing disease and for the maintenance of remission induced by biological therapy. IFX therapy was considered appropriate in 44%, uncertain in 44%, and inappropriate in 10% of patients. In this cohort, 9 out of 10 indications for IFX therapy were clinically generally acceptable (appropriate or uncertain) according to EPACT II criteria. Uncertain indications resulted mainly from the current more liberal use of IFX in clinical practice as compared with the EPACT II criteria.

  14. Longitudinal Study of the Transition From Healthy Aging to Alzheimer Disease

    Johnson, David K.; Storandt, Martha; Morris, John C.; Galvin, James E.

    2009-01-01

    Background Detection of the earliest cognitive changes signifying Alzheimer disease is difficult. Objective To model the cognitive decline in preclinical Alzheimer disease. Design Longitudinal archival study comparing individuals who became demented during follow-up and people who remained nondemented on each of 4 cognitive factors: global, verbal memory, visuospatial, and working memory. Setting Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri. Participants One hundred thirty-four individuals who became demented during follow-up and 310 who remained nondemented. Main Outcome Measures Inflection point in longitudinal cognitive performance. Results The best-fitting model for each of the 4 factors in the stable group was linear, with a very slight downward trend on all but the Visuospatial factor. In contrast, a piecewise model with accelerated slope after a sharp inflection point provided the best fit for the group that progressed. The optimal inflection point for all 4 factors was prior to diagnosis of dementia: Global, 2 years; Verbal and Working Memory, 1 year; and Visuospatial, 3 years. These results were also obtained when data were limited to the subset (n=44) with autopsy-confirmed Alzheimer disease. Conclusions There is a sharp inflection point followed by accelerating decline in multiple domains of cognition, not just memory, in the preclinical period in Alzheimer disease when there is insufficient cognitive decline to warrant clinical diagnosis using conventional criteria. Early change was seen in tests of visuospatial ability, most of which were speeded. Research into early detection of cognitive disorders using only episodic memory tasks may not be sensitive to all of the early manifestations of disease. PMID:19822781

  15. The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study.

    Cederlöf, Martin; Bergen, Sarah E; Långström, Niklas; Larsson, Henrik; Boman, Marcus; Craddock, Nick; Östberg, Per; Lundström, Sebastian; Sjölander, Arvid; Nordlind, Klas; Landén, Mikael; Lichtenstein, Paul

    2015-05-01

    Darier disease is an autosomal dominant skin disorder caused by mutations in the ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2) gene and previously reported to cosegregate with bipolar disorder and schizophrenia in occasional pedigrees. It is, however, unknown whether these associations exist also in the general population, and the objective of this study was to examine this question. We compared a national sample of individuals with Darier disease and their first-degree relatives with matched unexposed individuals from the general population and their first-degree relatives, respectively. To examine risks for bipolar disorder and schizophrenia, risk ratios and 95% confidence intervals (CIs) were estimated using conditional logistic regressions. Individuals with Darier disease had a 4.3 times higher risk of being diagnosed with bipolar disorder (95% CI: 2.6-7.3) and a 2.3 times higher risk of being diagnosed with schizophrenia (95% CI: 1.1-5.2) than matched individuals from the general population. Relatives of individuals with Darier disease had a 1.6 times higher risk of having bipolar disorder (95% CI: 1.1-2.5) than relatives of matched individuals from the general population, but no increased risk of schizophrenia (risk ratio = 0.8, 95% CI: 0.4-1.8). The association between Darier disease and bipolar disorder is manifest also in the population, and our data suggest that genetic variability within the ATP2A2 gene that causes Darier disease also confers susceptibility for bipolar disorder. The Darier-causing mutations merit additional attention in molecular genetic research on bipolar disorder. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Alcohol consumption and risk of recurrent cardiovascular events and mortality in patients with clinically manifest vascular disease and diabetes mellitus: The Second Manifestations of ARTerial (SMART) disease study

    Beulens, J.W.J.; Algra, A.; Soedamah-Muthu, S.S.; Visseren, F.L.J.; Grobbee, D.E.; Graaf, van der Y.

    2010-01-01

    OBJECTIVE: This study investigated the relation between alcohol consumption and specific vascular events and mortality in a high risk population of patients with clinical manifestations of vascular disease and diabetes. METHODS: Patients with clinically manifest vascular disease or diabetes (n=5447)

  17. Effect of childbirth on the course of Crohn's disease; results from a retrospective cohort study in the Netherlands

    Albers Lisette

    2011-01-01

    Full Text Available Abstract Background Pregnant women with Crohn's disease needs proper counselling about the effect of pregnancy and childbirth on their disease. However, Literature about the effect of childbirth on Crohn's disease is limited. This study examined the effect of childbirth on the course of Crohn's disease and especially perianal Crohn's disease. Methods This is a retrospective cohort study which was performed in a tertiary level referral hospital in the Netherlands. From the IBD database, female patients aged 18-80 years in 2004 were selected. Data analysis took place in the years 2005 and 2006. Eventually, 114 women with at least one pregnancy after the diagnosis of Crohn's disease were eligible for the study. Differences between groups were analyzed using Wilcoxon Mann Whitney tests and Chi-square analysis with 2 × 2 or 2 × 3 contingency tables. Two-tailed values were used and p values Results 21/114 women (18% had active luminal disease prior to pregnancy, with significantly more pregnancy related complications compared to women with inactive luminal disease (Odds ratio 2.8; 95% CI 1.0 - 7.4. Caesarean section rate was relatively high (37/114, 32%, especially in patients with perianal disease prior to pregnancy compared to women without perianal disease (Odds ratio 4.6; 95% CI 1.8 - 11.4. Disease progression after childbirth was more frequent in patients with active luminal disease prior to pregnancy compared to inactive luminal disease (Odds ratio 9.7; 95% CI 2.1 - 44.3. Progression of perianal disease seems less frequent after vaginal delivery compared with caesarean section, in both women with prior perianal disease (18% vs. 31%, NS and without prior perianal disease (5% vs 14%, NS. There were no more fistula-related complications after childbirth in women with an episiotomy or second degree tear. Conclusion A relatively high rate of caesarean sections was observed in women with Crohn's disease, especially in women with perianal disease

  18. The incidence of inflammatory bowel disease in Northern China: a prospective population-based study.

    Hong Yang

    Full Text Available AIMS & BACKGROUNDS: Although inflammatory bowel diseases (IBD are emerging and increasing in China, epidemiologic data are rarely available. This study was to investigate the epidemiological and clinical characteristics of IBD in Northern China. METHODS: This is a prospective, population-based study of incidence of IBD in Daqing, Heilongjiang province of Northern China from March 1, 2012 to February 28, 2013. All incident patients with IBD were clinically identified by IBD specialist group from five main General Hospitals covering the healthcare service for 1,343,364 residents in the urban areas of Daqing. IBD cases included in this study were followed-up for three months for diagnosis confirmation. RESULTS: A total of 27 new IBD cases including 25 cases of ulcerative colitis (UC and 2 cases of Crohn's disease (CD were identified. The population at risk was 1,343,364 person years. Age-adjusted incidence for total IBD, CD and UC were 1.77, 0.13, and 1.64 per 100,000 population, respectively. A male predominance was found in CD patients (male to female ratio was 2 ∶ 0. In contrast, no obvious gender predominance was found in UC patients (male to female ratio was 1 ∶ 1.1. CD patients were diagnosed at an average age of 39.5 years. The main disease phenotypes of UC were distal colitis with a 24% of proctitis and 56% of left-sided colitis. The mean diagnostic age of UC patients was 48.9 years. CONCLUSIONS: This is the first report on the incidence of IBD in the Northern Chinese population. A lower incidence of IBD, similar male predominance for CD, similar disease phenotype of UC, and lower disease activity was observed in Daqing compared to that in Southern China.

  19. Epidemiology of the Emergent Disease Paridae pox in an Intensively Studied Wild Bird Population

    Lachish, Shelly; Lawson, Becki; Cunningham, Andrew A.; Sheldon, Ben C.

    2012-01-01

    Paridae pox, a novel avipoxvirus infection, has recently been identified as an emerging infectious disease affecting wild tit species in Great Britain. The incursion of Paridae pox to a long-term study site where populations of wild tits have been monitored in detail for several decades provided a unique opportunity to obtain information on the local-scale epidemiological characteristics of this novel infection during a disease outbreak. Using captures of >8000 individual birds, we show that, within two years of initial emergence, Paridae pox had become established within the population of great tits (Parus major) reaching relatively high peak prevalence (10%), but was far less prevalent (<1%) in sympatric populations of several other closely related, abundant Paridae species. Nonlinear smoothing models revealed that the temporal pattern of prevalence among great tits was characterised by within-year fluctuations indicative of seasonal forcing of infection rates, which was likely driven by multiple environmental and demographic factors. There was individual heterogeneity in the course of infection and, although recovery was possible, diseased individuals were far less likely to be recaptured than healthy individuals, suggesting a survival cost of infection. This study demonstrates the value of long-term monitoring for obtaining key epidemiological data necessary to understand disease dynamics, spread and persistence in natural populations. PMID:23185230

  20. Epidemiology of the emergent disease Paridae pox in an intensively studied wild bird population.

    Shelly Lachish

    Full Text Available Paridae pox, a novel avipoxvirus infection, has recently been identified as an emerging infectious disease affecting wild tit species in Great Britain. The incursion of Paridae pox to a long-term study site where populations of wild tits have been monitored in detail for several decades provided a unique opportunity to obtain information on the local-scale epidemiological characteristics of this novel infection during a disease outbreak. Using captures of >8000 individual birds, we show that, within two years of initial emergence, Paridae pox had become established within the population of great tits (Parus major reaching relatively high peak prevalence (10%, but was far less prevalent (<1% in sympatric populations of several other closely related, abundant Paridae species. Nonlinear smoothing models revealed that the temporal pattern of prevalence among great tits was characterised by within-year fluctuations indicative of seasonal forcing of infection rates, which was likely driven by multiple environmental and demographic factors. There was individual heterogeneity in the course of infection and, although recovery was possible, diseased individuals were far less likely to be recaptured than healthy individuals, suggesting a survival cost of infection. This study demonstrates the value of long-term monitoring for obtaining key epidemiological data necessary to understand disease dynamics, spread and persistence in natural populations.

  1. Agent Orange exposure and disease prevalence in Korean Vietnam veterans: the Korean veterans health study.

    Yi, Sang-Wook; Hong, Jae-Seok; Ohrr, Heechoul; Yi, Jee-Jeon

    2014-08-01

    Between 1961 and 1971, military herbicides were used by the United States and allied forces for military purposes. Agent Orange, the most-used herbicide, was a mixture of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid, and contained an impurity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Many Korean Vietnam veterans were exposed to Agent Orange during the Vietnam War. The aim of this study was to evaluate the association between Agent Orange exposure and the prevalence of diseases of the endocrine, nervous, circulatory, respiratory, and digestive systems. The Agent Orange exposure was assessed by a geographic information system-based model. A total of 111,726 Korean Vietnam veterans were analyzed for prevalence using the Korea National Health Insurance claims data from January 2000 to September 2005. After adjusting for covariates, the high exposure group had modestly elevated odds ratios (ORs) for endocrine diseases combined and neurologic diseases combined. The adjusted ORs were significantly higher in the high exposure group than in the low exposure group for hypothyroidism (OR=1.13), autoimmune thyroiditis (OR=1.93), diabetes mellitus (OR=1.04), other endocrine gland disorders including pituitary gland disorders (OR=1.43), amyloidosis (OR=3.02), systemic atrophies affecting the nervous system including spinal muscular atrophy (OR=1.27), Alzheimer disease (OR=1.64), peripheral polyneuropathies (OR=1.09), angina pectoris (OR=1.04), stroke (OR=1.09), chronic obstructive pulmonary diseases (COPD) including chronic bronchitis (OR=1.05) and bronchiectasis (OR=1.16), asthma (OR=1.04), peptic ulcer (OR=1.03), and liver cirrhosis (OR=1.08). In conclusion, Agent Orange exposure increased the prevalence of endocrine disorders, especially in the thyroid and pituitary gland; various neurologic diseases; COPD; and liver cirrhosis. Overall, this study suggests that Agent Orange/2,4-D/TCDD exposure several decades earlier may increase morbidity

  2. Blue moon neurovirology: the merits of studying rare CNS diseases of viral origin.

    O'Donnell, Lauren A; Rall, Glenn F

    2010-09-01

    While measles virus (MV) continues to have a significant impact on human health, causing 150,000-200,000 deaths worldwide each year, the number of fatalities that can be attributed to MV-triggered central nervous system (CNS) diseases are on the order of a few hundred individuals annually (World Health Organization 2009). Despite this modest impact, substantial effort has been expended to understand the basis of measles-triggered neuropathogenesis. What can be gained by studying such a rare condition? Simply stated, the wealth of studies in this field have revealed core principles that are relevant to multiple neurotropic pathogens, and that inform the broader field of viral pathogenesis. In recent years, the emergence of powerful in vitro systems, novel animal models, and reverse genetics has enabled insights into the basis of MV persistence, the complexity of MV interactions with neurons and the immune system, and the role of immune and CNS development in virus-triggered disease. In this review, we highlight some key advances, link relevant measles-based studies to the broader disciplines of neurovirology and viral pathogenesis, and propose future areas of study for the field of measles-mediated neurological disease.

  3. Parkinson's disease as community health problem: study in Norwegian nursing homes. The Norwegian Study Group of Parkinson's Disease in the Elderly.

    Larsen, J P

    1991-01-01

    OBJECTIVE--To examine the extent of under-diagnosis and overdiagnosis of Parkinson's disease and to determine quality of treatment in a defined population. DESIGN--Clinical evaluation of an elderly population. SETTING--40 Norwegian nursing homes. SUBJECTS--3322 residents of nursing homes, of whom 500 were selected by nursing staff for evaluation on the basis of a structured information programme on Parkinson's disease and 269 were examined in detail by neurologists. MAIN OUTCOME MEASURES--Pat...

  4. The Association between Residence Floor Level and Cardiovascular Disease: The Health and Environment in Oslo Study.

    Rohde, Mads K; Aamodt, Geir

    2016-01-01

    Background. Increasingly more people live in tall buildings and on higher floor levels. Factors relating to floor level may protect against or cause cardiovascular disease (CVD). Only one previous study has investigated the association between floor level and CVD. Methods. We studied associations between floor of bedroom and self-reported history of stroke, venous thromboembolism (VTE), and intermittent claudication (IC) among 12.525 inhabitants in Oslo, Norway. We fitted multivariate logistic regression models and adjusted for sociodemographic variables, socioeconomic status (SES), and health behaviors. Additionally, we investigated block apartment residents ( N = 5.374) separately. Results. Trend analyses showed that disease prevalence increased by floor level, for all three outcomes. When we investigated block apartment residents alone, the trends disappeared, but one association remained: higher odds of VTE history on 6th floor or higher, compared to basement and 1st floor (OR: 1.504; 95% CI: 1.007-2.247). Conclusion. Floor level is positively associated with CVD, in Oslo. The best-supported explanation may be residual confounding by building height and SES. Another explanation, about the impact of atmospheric electricity, is also presented. The results underline a need to better understand the associations between residence floor level and CVD and multistory housing and CVD.

  5. Study on the changes of serum HA and CG levels in several diseases besides liver disorders

    Zhiping, Lu; Yunbao, Ma; Xiaoyi, Zhang; Weihua, Lv [Changshu Hospital Attached to Medical College of Yangzhou Univ., Changshu No.2 People' s Hospital, Changshu (China)

    2005-12-15

    Objective: To study the changes of serum hyaluronic acid (HA) and cholyglycine (CG) in several diseases besides liver disorders. Methods: Serum HA and CG levels were measured with RIA in 78 patients with chronic liver diseases (with 70 controls), (84 patients with primary hepatic carcinoma ), 70 pediatric patients with various infections diseases (with 40 controls), 50 pediatric patients with recurrent respiratory infection (RRI, with 30 controls) and 428 pregnant women ( with 60 controls). In addition, RBC C{sub 3}b receptor ratio (RBCC{sub 3} bRR) and RBC immune-complex ratio (RBCICR) (both with yeast rosette method) as well as serum IgG,IgM,IgA,C{sub 3} levels (with immunoturbidity test) were examined in the 50 RRI pediatric patients, ALT levels were examined in the 70 pediatric patients with infectious diseases and SF examined in the 78 patients with chronic liver diseases. Results: The serum CG, HA and SF levels in the three groups of patients with chronic liver diseases ( CPH, CAH, Cirrhosis) were significantly higher than those in the controls (all P<0.01 ) with the exception of HA in CPH patients (P > 0.05). In patients with hepatic carcinoma, the CG and HA levels were positively correlated with the mortality at 4 months (P < 0.05). Among pregnant women, serum levels of HA and CG were significantly higher during the second and third trimesters (P<0.05-0.01) than those in the controls but not so during the first trimester. In the pediatric patients with infectious diseases, CG and HA levels were significantly higher in all these patients (P<0.01) with the only exception of HA in patients with mumps (P>0.05). For ALT, levels only increased in patients with hepatitis and typhoid fever with none in bacillary dysentery and mumps. In pediatric patients with RRI, RBCC{sub 3}bRR (%), CG, C{sub 3}, IgG levels were significantly higher than those in controls (P<0.05 ) with no significant differences in the case of RBCICR (%), HA, IgM and IgA levels (P>0

  6. Lady Gaga - hiperrzeczywisty buntownik na sprzedaż jako propozycja tożsamościowa dla globalnej młodzieży

    Wierzba, Paulina

    2013-01-01

    The article analyzes the phenomenon of Lady Gaga, one of the biggest modern culture icons. It shows the influence of the figure on the identity of global youth being constructed. Her image, videos, rhythm and song lyrics describe and express life experience of global teenagers, socializing them to their function in modern reality. The author tries to prove that in contemporary reality even a rebellion has become a product to sell. Youth idols who have undergone the way from counter-culture to...

  7. Usefulness of CT based SPECT Fusion Image in the lung Disease : Preliminary Study

    Park, Hoon Hee; Lyu, Kwang Yeul; Kim, Tae Hyung; Shin, Ji Yun

    2012-01-01

    Recently, SPECT/CT system has been applied to many diseases, however, the application is not extensively applied at pulmonary disease. Especially, in case that, the pulmonary embolisms suspect at the CT images, SPECT is performed. For the accurate diagnosis, SPECT/CT tests are subsequently undergoing. However, without SPECT/CT, there are some limitations to apply these procedures. With SPECT/CT, although, most of the examination performed after CT. Moreover, such a test procedures generate unnecessary dual irradiation problem to the patient. In this study, we evaluated the amount of unnecessary irradiation, and the usefulness of fusion images of pulmonary disease, which independently acquired from SPECT and CT. Using NEMA PhantomTM (NU2-2001), SPECT and CT scan were performed for fusion images. From June 2011 to September 2010, 10 patients who didn't have other personal history, except lung disease were selected (male: 7, female: 3, mean age: 65.3±12.7). In both clinical patient and phantom data, the fusion images scored higher than SPECT and CT images. The fusion images, which is combined with pulmonary vessel images from CT and functional images from SPECT, can increase the detection possibility in detecting pulmonary embolism in the resin of lung parenchyma. It is sure that performing SPECT and CT in integral SPECT/CT system were better. However, we believe this protocol can give more informative data to have more accurate diagnosis in the hospital without integral SPECT/CT system.

  8. Diabetes and modifiable risk factors for cardiovascular disease: the prospective Million Women Study

    Spencer, Elizabeth A.; Pirie, Kirstin L.; Stevens, Richard J.; Beral, Valerie; Brown, Anna; Liu, Bette; Green, Jane; Reeves, Gillian K.

    2008-01-01

    To compare the effect of potentially modifiable lifestyle factors on the incidence of vascular disease in women with and without diabetes. In 1996-2001 over one million middle-aged women in the UK joined a prospective study, providing medical history, lifestyle and socio-demographic information. All participants were followed for hospital admissions and deaths using electronic record-linkage. Adjusted relative risks (RRs) and incidence rates were calculated to compare the incidence of coronary heart disease and stroke in women with and without diabetes and by lifestyle factors. At recruitment 25,915 women (2.1% of 1,242,338) reported current treatment for diabetes. During a mean follow-up of 6.1 years per woman, 21,928 had a first hospital admission or death from coronary heart disease (RR for women with versus without diabetes = 3.30, 95% CI 3.14-3.47) and 7,087 had a first stroke (RR = 2.47, 95% CI 2.24-2.74). Adjusted incidence rates of these conditions in women with diabetes increased with duration of diabetes, obesity, inactivity and smoking. The 5-year adjusted incidence rates for cardiovascular disease were 4.6 (95% CI 4.4-4.9) per 100 women aged 50-69 in non-smokers with diabetes, 5.9 (95% CI 4.6-7.6) in smokers with diabetes not using insulin and 11.0 (95% CI 8.3-14.7) in smokers with diabetes using insulin. Non-smoking women with diabetes who were not overweight or inactive still had threefold increased rate for coronary disease or stroke compared with women without diabetes. Of the modifiable factors examined in middle aged women with diabetes, smoking causes the greatest increase in cardiovascular disease, especially in those with insulin treated diabetes

  9. Bibliometric study of research and development for neglected diseases in the BRICS.

    Bai, Jing; Li, Wei; Huang, Yang-Mu; Guo, Yan

    2016-09-06

    Large numbers of people are suffering from a group of diseases that mainly affect developing countries, as there are no available or affordable products for prevention or treatment. Research and development (R&D) for these diseases is still a low priority on the health agenda. Brazil, Russia, India, China and South Africa (BRICS) are quickly growing economies and having more and more positive impact on global health. Additionally, their R&D capacity is believed to be enhanced through decades of investment in education and life science research. The BRICS, as a group of emerging and developing countries, are expected to make greater contributions to solving the problem that mainly affects the entire developing countries community. However, there has been little research to provide a macroscopic overview of BRICS' effort in R&D for neglected diseases. The aim of this study is to investigate scientific production in BRICS countries in this area and their main research hotspots. Global relevant literature was searched without time limits through PubMed and high yield countries were identified using GoPubMed. Literature up to the end of 2013 from the BRICS was obtained and high frequency words were extracted and clustered using Bibliography Item Co-occurrence Mining System 2.0 (BICOMS) and Graphical Clustering Toolkit 1.0 (gCLUTO). In total, 32, 47, 51, 31 and 44 high frequency words from Brazil, Russia, India, China and South Africa respectively were extracted for clustering analysis. The clustering indicated that eight diseases were research hotspots in BRICS countries. India had the most extensive hotspots and Brazil came in second. The other three countries shared common research foci: helminthiasis, Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome (HIV/AIDS) and tuberculosis. Developed countries still make the majority of contributions to R&D on neglected diseases, but BRICS countries are playing a growing role. Instead of the "big

  10. The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration.

    Gorusupudi, Aruna; Nelson, Kelly; Bernstein, Paul S

    2017-01-01

    Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies. A wide variety of nutrients, such as minerals, vitamins, ω-3 (n-3) fatty acids, and various carotenoids, have been associated with reducing the risk of AMD. Initial results from the Age-Related Eye Disease Study (AREDS) indicated that supplementation with antioxidants (β-carotene and vitamins C and E) and zinc was associated with a reduced risk of AMD progression. The AREDS2 follow-up study, designed to improve upon the earlier formulation, tested the addition of lutein, zeaxanthin, and ω-3 fatty acids. In this review, we examine the science behind the nutritional factors included in these interventional studies and the reasons for considering their inclusion to lower the rate of AMD progression. © 2017 American Society for Nutrition.

  11. The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration123

    Gorusupudi, Aruna; Nelson, Kelly; Bernstein, Paul S

    2017-01-01

    Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress–related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies. A wide variety of nutrients, such as minerals, vitamins, ω-3 (n–3) fatty acids, and various carotenoids, have been associated with reducing the risk of AMD. Initial results from the Age-Related Eye Disease Study (AREDS) indicated that supplementation with antioxidants (β-carotene and vitamins C and E) and zinc was associated with a reduced risk of AMD progression. The AREDS2 follow-up study, designed to improve upon the earlier formulation, tested the addition of lutein, zeaxanthin, and ω-3 fatty acids. In this review, we examine the science behind the nutritional factors included in these interventional studies and the reasons for considering their inclusion to lower the rate of AMD progression. PMID:28096126

  12. A Study of the U.S. Capacity to Address Tropical Disease Problems

    1986-04-01

    associated with a range of symptoms, can lead to jaundice, renal insufficiency, and anemia . Case fatality rates can be as high as 20 percent in high...an important federal center for research on tropical disease pathogens. Army studies of anemia in Puerto Rico led to the discovery of hookworm as the...vaccine development and testing. The university has research links with groups in Chile and Peru . The University of Washington has a similar program, on

  13. A cross-sectional study of self-reported general health, lifestyle factors, and disease: the Hordaland Health Study

    Randi Jepsen

    2014-10-01

    Full Text Available Background. Information on self-reported health is important for health professionals, and the aim of this study was to examine associations between lifestyle factors and self-reported health and the mediating effect of disease in a Norwegian population.Methods and Materials. The data collection was conducted as part of the Hordaland Health Study (HUSK 1997–99, which was a cross-sectional epidemiological study. All individuals in Hordaland county born in 1953–1957 were invited to participate (aged 40–44 years. Complete information for the present study was obtained from 12,883 individuals (44% response rate. Height and weight were measured at a physical examination. Information on lifestyle factors, self-reported health, disease (heart attack, apoplexy, angina pectoris, and diabetes, and socio-demographic variables was obtained from a self-administered questionnaire. Self-reported health was measured with a one-item question. Odds ratios for fair or poor self-reported health were calculated using multiple logistic regression analyses adjusted for disease and socio-demographic variables.Results. Respondents reporting adverse lifestyle behaviours (obesity (odds ratio (OR 1.7, p < 0.001, smoking (OR 1.2, p < 0.001, or excessive intake of alcohol (OR 3.3, p < 0.001 showed an increased risk of poor self-reported health. Furthermore, a moderate intake of wine (OR 0.6, p < 0.001 or strenuous physical activity (OR 0.5, p < 0.001 decreased the risk of poor health. Disease did not mediate the effect.Conclusion. A one-item question measuring self-reported health may be a suitable measure for health professionals to identify levels of subjective health and reveal a need to target lifestyle factors in relatively young individuals with or without disease.

  14. The clinical characteristics of adults with rheumatic heart disease in Yangon, Myanmar: An observational study.

    Myint, Nan Phyu Sin Toe; Aung, Ne Myo; Win, Myint Soe; Htut, Thu Ya; Ralph, Anna P; Cooper, David A; Nyein, Myo Lwin; Kyi, Mar Mar; Hanson, Josh

    2018-01-01

    Rheumatic heart disease (RHD) is a major cause of premature death in low and middle-income countries. The greatest barrier to RHD control is neglect of the disease in national health policies and a lack of prevalence data that might inform control efforts. Myanmar is making remarkable progress against many infectious diseases, but there are almost no data to define the clinical burden of RHD in the country. This prospective audit was performed in an adult medical ward of a tertiary-referral hospital in Yangon, to gain an insight into the prevalence of RHD in Myanmar. All patients admitted to the ward between May 1, 2016 and April 30, 2017 were eligible for enrolment. RHD was confirmed in 96 patients who were admitted on 134 occasions, representing 1.1% of the 12,172 adult medical admissions during the study period. This compared with 410 (3.4%) admissions with HIV and 14 (0.1%) with malaria. Patients with RHD had a median age of 44 years (interquartile range: 35-59); 70 (73%) were female. Only one patient had ever had surgery despite 79 (82%) meeting criteria for intervention; 54 (56%) patients were not receiving any regular clinician review. Prior to hospitalisation only 18 (19%) patients were receiving regular penicillin. Only 8 (19%) of the 42 women Myanmar. A national RHD programme would improve patient care, reducing morbidity and mortality from this preventable disease.

  15. Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study.

    Hueper, Katja; Vogel-Claussen, Jens; Parikh, Megha A; Austin, John H M; Bluemke, David A; Carr, James; Choi, Jiwoong; Goldstein, Thomas A; Gomes, Antoinette S; Hoffman, Eric A; Kawut, Steven M; Lima, Joao; Michos, Erin D; Post, Wendy S; Po, Ming Jack; Prince, Martin R; Liu, Kiang; Rabinowitz, Dan; Skrok, Jan; Smith, Ben M; Watson, Karol; Yin, Youbing; Zambeli-Ljepovic, Alan M; Barr, R Graham

    2015-09-01

    Smoking-related microvascular loss causes end-organ damage in the kidneys, heart, and brain. Basic research suggests a similar process in the lungs, but no large studies have assessed pulmonary microvascular blood flow (PMBF) in early chronic lung disease. To investigate whether PMBF is reduced in mild as well as more severe chronic obstructive pulmonary disease (COPD) and emphysema. PMBF was measured using gadolinium-enhanced magnetic resonance imaging (MRI) among smokers with COPD and control subjects age 50 to 79 years without clinical cardiovascular disease. COPD severity was defined by standard criteria. Emphysema on computed tomography (CT) was defined by the percentage of lung regions below -950 Hounsfield units (-950 HU) and by radiologists using a standard protocol. We adjusted for potential confounders, including smoking, oxygenation, and left ventricular cardiac output. Among 144 participants, PMBF was reduced by 30% in mild COPD, by 29% in moderate COPD, and by 52% in severe COPD (all P emphysema-950HU and radiologist-defined emphysema, particularly panlobular and centrilobular emphysema (all P ≤ 0.01). Registration of MRI and CT images revealed that PMBF was reduced in mild COPD in both nonemphysematous and emphysematous lung regions. Associations for PMBF were independent of measures of small airways disease on CT and gas trapping largely because emphysema and small airways disease occurred in different smokers. PMBF was reduced in mild COPD, including in regions of lung without frank emphysema, and may represent a distinct pathological process from small airways disease. PMBF may provide an imaging biomarker for therapeutic strategies targeting the pulmonary microvasculature.

  16. Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol

    Norden, A.G.W. van; Laat, K.F. de; Gons, R.A.R.; Uden, I.W.M. van; Dijk, E.J. van; Oudheusden, L.J.B. van; Esselink, R.A.J.; Bloem, B.R.; Engelen, B.G.M. van; Zwarts, M.J.; Tendolkar, I.; Olde-Rikkert, M.G.M.; Vlugt, M.J. van der; Zwiers, M.P.; Norris, D.G.; Leeuw, F.E. de

    2011-01-01

    BACKGROUND: Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects

  17. Analisis Pengaruh Hedonic Shopping Tendency Dan Visual Merchandising Terhadap Impulse Buying Dengan Positive Emotion Sebagai Variabel Intervaning Pada Area Ladies Matahari Department Store Tunjungan Plaza Surabaya

    Yanthi, Devi

    2014-01-01

    This research tried to determine what factors are causing consumers to do impulse buying in the area of ladies at Matahari Department Store. Variables examined in this research include hedonic shopping tendency and visual merchandising as the independent variable, positive emotion as the intervening variable, and impulse buying as the dependent variable. The sample used amounted 100 rerspondents. By using PLS-SEM analysis technique, demonstrated that through positive emotion variables, hedoni...

  18. Blood folate is associated with asymptomatic or partially symptomatic Alzheimer's disease in the Nun study.

    Wang, Huifen; Odegaard, Andrew; Thyagarajan, Bharat; Hayes, Jennifer; Cruz, Karen Santa; Derosiers, Mark F; Tyas, Suzanne L; Gross, Myron D

    2012-01-01

    Asymptomatic and partially symptomatic Alzheimer's disease (APSYMAD) are a series of cognitive states wherein subjects have substantial Alzheimer's disease (AD) pathology (classification B or C by the Consortium to Establish a Registry for AD criteria), but have normal or only partially impaired cognitive function; all of these subjects are non-demented. These cognitive states may arise from the prevention or delay of clinical symptom expression by exposure to certain nutritional factors. This study examined blood levels of folate and antioxidants (i.e., carotenoids) in relation to APSYMAD, nested in the Nun study, a longitudinal study of aging and AD. Sixty elderly female subjects, who had AD on the basis of neuropathology exams, were included. Following adjustment for APOE4 status, education level, and age at blood draw, subjects with the highest blood folate levels had a higher likelihood of being in the APSYMAD group as compared to the demented (AD) group (odds ratio = 1.09, 95% CI = 1.00-1.18. p < 0.06). This association was not significantly influenced by additional adjustment for blood concentrations of carotenoids. Restriction of the population to subjects with near normal cognition on the cognitive state score (score = 1-3) indicated an elevated association with blood folate (odds ratio = 1.12, 95% CI = 1.01-1.25, p < 0.04). Blood carotenoids were not associated with APSYMAD. Thus, folate status may influence the expression of clinical symptoms of AD disease and aid in the delay or prevention of dementia.

  19. Probiotics in diverticular disease of the colon: an open label study.

    Lamiki, Pepu; Tsuchiya, Junji; Pathak, Surajit; Okura, Ruichi; Solimene, Umberto; Jain, Shalini; Kawakita, Shichiro; Marotta, Francesco

    2010-03-01

    To investigate the effectiveness and safety of a symbiotic mixture in preventing recurrence of constipation-related abdominal pain in patients with uncomplicated diverticular disease of the colon. Forty-six consecutive patients (10 men, 36 women, mean age 62.5 years, range 49 to 77 years), previously affected by symptomatic uncomplicated diverticular disease of the colon, were enrolled in a 6-month follow-up study in a prospective, randomized, open-label study. The following symptoms were assessed at entry and through follow-up by using a quantitative scale: constipation, diarrhoea and abdominal pain. After recruitment, the patients were assigned to the following treatment: SCM-III symbiotic mixture, 10 ml three times a day. The colonization of ingested Lactobacillus acidophilus 145 and Bifidobacterium spp. 420 was assessed by species-specific PCR. Forty-five patients completed the study (97%). Thirty-one patients (68%) were still symptom free after the 6th month of treatment. Treatment with SCM-III was regarded as "effective" or "very effective" in more than 78% of the patients altogether (pdiverticular disease of the colon, especially in those patients with constipation-predominant features.

  20. Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies.

    Hon-Cheong So

    2010-11-01

    Full Text Available Recently genome-wide association studies (GWAS have identified numerous susceptibility variants for complex diseases. In this study we proposed several approaches to estimate the total number of variants underlying these diseases. We assume that the variance explained by genetic markers (Vg follow an exponential distribution, which is justified by previous studies on theories of adaptation. Our aim is to fit the observed distribution of Vg from GWAS to its theoretical distribution. The number of variants is obtained by the heritability divided by the estimated mean of the exponential distribution. In practice, due to limited sample sizes, there is insufficient power to detect variants with small effects. Therefore the power was taken into account in fitting. Besides considering the most significant variants, we also tried to relax the significance threshold, allowing more markers to be fitted. The effects of false positive variants were removed by considering the local false discovery rates. In addition, we developed an alternative approach by directly fitting the z-statistics from GWAS to its theoretical distribution. In all cases, the "winner's curse" effect was corrected analytically. Confidence intervals were also derived. Simulations were performed to compare and verify the performance of different estimators (which incorporates various means of winner's curse correction and the coverage of the proposed analytic confidence intervals. Our methodology only requires summary statistics and is able to handle both binary and continuous traits. Finally we applied the methods to a few real disease examples (lipid traits, type 2 diabetes and Crohn's disease and estimated that hundreds to nearly a thousand variants underlie these traits.

  1. Study on Analysis and Pattern Recognition of the Manifestation of the Pulse Detection of Cerebrovascular Disease

    Jing, J; Wang, Y C; Hong, W X; Zhang, W P [Department of Biomedical Engineering, University of Yanshan, Qinhuangdao, Hebei Province, 066004 (China)

    2006-10-15

    Cerebrovascular Disease (CVD) is also called stroke in Traditional Chinese Medicine (TCM). CVD is a kind of frequent diseases with high incidence, high death rate, high deformity rate and high relapse rate. The pathogenesis of CVD has relation to many factors. In modern medicine, we can make use of various instruments to check many biochemical parameters. However, at present, the early detection of CVD can mostly be done artificially by specialists. In TCM the salted expert can detect the state of a CVD patient by felling his (or her) pulse. It is significant to apply the modern information and engineering techniques to the early discovery of CVD. It is also a challenge to do this in fact. In this paper, the authors presented a detection method of CVD basing on analysis and pattern recognition of Manifestation of the Pulse of TCM using wavelet technology and Neural Networks. Pulse signals from normal health persons and CVD patients were studied comparatively. This research method is flexible to deal with other physiological signals.

  2. Naturalizing Alterity: Edward Maturin’s Bianca: A Tale of Erin and Italy and Lady Morgan's Italy

    Donatella Abbate Badin

    2011-08-01

    Full Text Available In the nineteenth century the image of Italy appealed also to Irish Romantic writers. But the way in which they naturalized the Italian alterity is quite ambivalent. On the one hand they filtered their images of the southern country through their relationship with England and thus ended up mirroring stereotypes common to the English-speaking world, and on the other hand they established a special, personal relationship with it shaped by their ideological and cultural differences from the British. This essay tackles the representations of Italy in two texts, namely Edward Maturin’s Bianca: A Tale of Erin and Italy, published in 1852, and in the earlier Italy (1821 by Lady Morgan. Both these works show that at that time there was a certain awareness, in Ireland, of the special historical and political conditions of Italy and of possible similarities with Ireland. Italy, oppressed by foreign domination yet aspiring to freedom, became a yardstick for gauging issues of subjugation, injustice, and national identity and invited sympathy from the citizens of a colonized country. Therefore, Italy was perceived as a mirror in which to reflect the Irish identity torn by aspirations which were hard to confess publicly or even to oneself. Keywords: Maturin, Lady Morgan, alterity, Italy, Irish Romanticism

  3. Study of the hypothalamic - hypophyseal - thyroid axis by the administration of TRH to Chagas' disease patients

    Abelin, N.M.A.

    1978-01-01

    The TSH and T 3 response to synthetic TRH was evaluated in two groups of patients: normal and with Chagas' disease, from the urban area of Sao Paulo (Brazil). Plasma T 4 , PBI and TSH values were within the normal range, when compared with those found in the controls: So were the thyroid uptakes of 2 and 24 hours; the basal levels of T 3 where within the normal range except in three subjects whose values were higher than normal. After TRH administration the amount of TSH secretion in patients with Chagas' disease was increased when compared to normal ones, while T 3 secretion was unaltered. It is suggested that in the Chagas' disease there is an increase in the pituitary TSH, while the thyroid reserve is preserved. This increase could be due to a difference in the regulation rate of TRH, which is determined by the neuronal degeneration caused by the disease itself. (author) [pt

  4. Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study.

    Mohan, Venkata Raghava; Karthikeyan, Ramanujam; Babji, Sudhir; McGrath, Monica; Shrestha, Sanjaya; Shrestha, Jasmin; Mdumah, Estomih; Amour, Caroline; Samie, Amidou; Nyathi, Emanuel; Haque, Rashidul; Qureshi, Shahida; Yori, Pablo Peñataro; Lima, Aldo A M; Bodhidatta, Ladaporn; Svensen, Erling; Bessong, Pascal; Ahmed, Tahmeed; Seidman, Jessica C; Zaidi, Anita K M; Kosek, Margaret N; Guerrant, Richard L; Gratz, Jean; Platts-Mills, James A; Lang, Dennis R; Gottlieb, Michael; Houpt, Eric R; Kang, Gagandeep

    2017-08-01

    In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. A total of 1737 children contributed 22646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  5. Relevance of the Studying Quality of Life Indicator in Children with Allergic Diseases

    O.Ya. Tkachenko

    2013-11-01

    Full Text Available This overview focuses on global issues and conceptual approaches to understanding the quality of life. Despite the fairly large number of questionnaires for children, the data in this article demonstrate that the definition of quality of life should be more widely used in pediatric studies. Recently, this criterion is most frequently used to analyze the quality of medical care for patients with chronic diseases. Assessment of quality of life in children with allergic diseases, such as bronchial asthma, allergic rhinitis, urticaria, is especially important. This is primarily due to the high prevalence of allergic pathology, as well as its significant influence on the daily lives of patients, which certainly involves important social and economic spheres of activity. Improving quality of life is strongly correlated with the appropriate treatment, which is clearly demonstrated by the patients with bronchial asthma, especially in the pediatric population.

  6. The study of platelet function in chronic renal diseases by radioimmunoassay-(RIA)

    Li Fugang; Wu Guoxin; Li Peixia; Ruan Changgeng

    1992-07-01

    The platelet function in patients with chronic renal diseases was studied by radioimmunoassay methods. In the patients with nephritic syndrome, the number of molecules of GMP-140 on the platelet surface and in plasma was greatly increased, and the concentrations of TXB 2 and β-TG in plasma was increased as well. In the patients with uremia, increased β-TG and decreased TXB 2 in plasma were found in comparison with those of control. In the patients with chronic glomerulonephritis, the platelet changed only slightly. These results suggest that the platelet function in patients with nephritic syndrome and uremia changes greatly and plays an important role in the progress of chronic renal diseases

  7. Vector-borne diseases and the basic reproduction number: a case study of African horse sickness

    Lord, C.C.; Woolhouse, M.E.J.; Heesterbeek, J.A.P.; Mellor, P.S.

    1996-01-01

    The basic reproduction number, R0, can be used to determine factors important in the ability of a disease to invade or persist. We show how this number can be derived or estimated for vector-borne diseases with different complicating factors. African horse sickness is a viral disease transmitted

  8. Thyroid Autoantibodies and the Clinical Presentation of Moyamoya Disease: A Prospective Study.

    Lanterna, Luigi A; Galliani, Silvia; Zangari, Rosalia; Conti, Luciano; Brembilla, Carlo; Gritti, Paolo; Colleoni, Maria Luisa; Bernucci, Claudio

    2018-05-01

    Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never been studied. The objective of this study was to investigate the relationship between thyroid autoantibodies and the clinical presentation of moyamoya. This is a prospective study including 37 patients with moyamoya disease (MMD) or unilateral moyamoya (uMM). Thyroid function and thyroid autoantibodies (e.g., antithyroperoxidase and antithyroglobulin) were investigated. We studied the effect of gender, age, type of moyamoya (uMM versus MMD), and thyroid autoantibodies on the clinical presentation, dichotomized into aggressive (hemorrhage, major stroke, or frequent transient ischemic attack [TIA]) and nonaggressive presentation (headache, rare TIAs, and incidental diagnosis) according to the criteria of the Research Committee on Spontaneous Occlusion of the Circle of Willis. Of the 37 patients included in the study, the autoantibodies were elevated in 9 (24.3%). An aggressive presentation occurred in 21 patients (hemorrhage in 11, major stroke in 9, frequent TIAs in 1). The autoantibodies were elevated in 8 of the 21 patients (38.09%) with an aggressive presentation and in 1 of those presenting with minor symptoms (6.2%). The presence of elevated autoantibodies was the only variable associated with an aggressive presentation in the multivariate logistic analysis (P = .048). When the serum concentration of the thyroid autoantibodies is increased, the patients have a higher risk of an aggressive presentation. Our results support the hypothesis that activation of immune-mediated processes affects the moyamoya physiopathology. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  9. Determining the disease management process for epileptic patients: A qualitative study.

    Hosseini, Nazafarin; Sharif, Farkhondeh; Ahmadi, Fazlollah; Zare, Mohammad

    2016-01-01

    Epilepsy exposes patients to many physical, social, and emotional challenges. Thus, it seems to portray a complex picture and needs holistic care. Medical treatment and psychosocial part of epilepsy remain central to managing and improving the patient's qualify of life through team efforts. Some studies have shown the dimensions of self-management, but its management process of epilepsy patients, especially in Iran, is not clear. This study aimed to determine the disease management process in patients with epilepsy in Iran. This qualitative approach and grounded theory study was conducted from January 2009 to February 2012 in Isfahan city (Iran). Thirty-two participants were recruited by the goal-oriented, and snowball sample selection and theoretical sampling methods. After conducting a total of 43 in-depth interviews with the participants, the researchers reached data saturation. Data were analyzed using Strauss and Corbin method. With a focus on disease management process, researchers found three main themes and seven sub-themes as a psychosocial process (PSP). The main themes were: perception of threat to self-identity, effort to preserve self-identity, and burn out. The psychosocial aspect of the disease generated one main variable "the perception of identity loss" and one central variable "searching for self-identity." Participants attributed threat to self-identity and burn out to the way their disease was managed requiring efforts to preserve their identity. Recommendations consist of support programs and strategies to improve the public perception of epilepsy in Iran, help patients accept their condition and preserve self-identity, and most importantly, enhance medical management of epilepsy.

  10. State of the Art Coronary Heart Disease Risk Estimation based on the Framingham Heart Study

    Reissigová, Jindra; Tomečková, Marie

    2005-01-01

    Roč. 13, č. 4 (2005), s. 180-186 ISSN 0022-1732 Institutional research plan: CEZ:AV0Z10300504 Keywords : Framingham heart study * coronary heart disease * risk validation study * calibration * discrimination Subject RIV: BA - General Mathematics

  11. The clinical significance of brain microbleeds in patients with Alzheimer′s disease: Preliminary study

    Jae-Hyeok Heo

    2016-01-01

    Full Text Available Background: Microbleeds (MBs are observed frequently in Alzheimer′s disease (AD and suggested to play a crucial role in the pathophysiology, but their clinical significance remains unclear. Materials and Methods: The study recruited 100 patients with AD who were diagnosed at the memory clinic in Seoul Medical Center in 2014. For each patient, baseline characteristics, neuropsychological tests, cerebrovascular risk factors, medial temporal lobe atrophy (MTLA, and severity of small vessel disease (SVD according to the existence of MBs were evaluated. Results: The prevalence of MBs in patients with AD was 33%. The percentage of male gender, the severity of SVD and MTLA were significantly increased in MB(+ group. The MB(+ group showed more severe MTLA and SVD than MB(− group. Conclusions: These results suggested that MBs might reflect the burden of amyloid and ischemic vascular pathology.

  12. ZIP13: A Study of Drosophila Offers an Alternative Explanation for the Corresponding Human Disease

    Guiran Xiao

    2018-01-01

    Full Text Available The fruit fly Drosophila melanogaster has become an important model organism to investigate metal homeostasis and human diseases. Previously we identified dZIP13 (CG7816, a member of the ZIP transporter family (SLC39A and presumably a zinc importer, is in fact physiologically primarily responsible to move iron from the cytosol into the secretory compartments in the fly. This review will discuss the implication of this finding for the etiology of Spondylocheirodysplasia-Ehlers-Danlos Syndrome (SCD–EDS, a human disease defective in ZIP13. We propose an entirely different model in that lack of iron in the secretory compartment may underlie SCD-EDS. Altogether three different working models are discussed, supported by relevant findings made in different studies, with uncertainties, and questions remained to be solved. We speculate that the distinct ZIP13 sequence features, different from those of all other ZIP family members, may confer it special transport properties.

  13. Prevalence of autoantibodies in the course of Gaucher disease type 1: A multicenter study comparing Gaucher disease patients to healthy subjects.

    Serratrice, Christine; Bensalah, Nesma; Penaranda, Guillaume; Bardin, Nathalie; Belmatoug, Nadia; Masseau, Agathe; Rose, Christian; Lidove, Olivier; Camou, Fabrice; Maillot, François; Leguy, Vanessa; Magy-Bertrand, Nadine; Marie, Isabelle; Cherin, Patrick; Bengherbia, Monia; Carballo, Sebastian; Boucraut, José; Serratrice, Jacques; Berger, Marc; Verrot, Denis

    2018-01-01

    Type 1 Gaucher disease may be related to the presence of autoantibodies. Their clinical significance is questioned. Primary endpoint was to compare the prevalence of autoantibodies in type 1 Gaucher disease patients with healthy subjects, seeking correlations with autoimmune characteristics. Secondary endpoints were to determine whether patients with autoantibodies reported autoimmunity-related symptoms and if genotype, splenectomy or treatment influenced autoantibodies presence. Type 1 Gaucher disease patients and healthy volunteers were included in this national multicenter exploratory study. Autoantibodies presence was compared in both groups and assessed regarding to genotype, splenectomy, Gaucher disease treatment and autoimmunity-related symptoms. Twenty healthy subjects and 40 type 1 Gaucher disease patients were included. Of the studied group: 15 patients undergone splenectomy, 37 were treated either with enzyme replacement therapy (34) or with substrate reduction therapy (3), 25 were homozygous/heterozygous for the N370S mutation. In type 1 Gaucher disease group (studied group), 52% had positive autoantibodies versus 26% in control group. Antiphospholipid antibodies were more frequent in the studied group (30% vs. 5%), but without correlation to thrombosis, osteonecrosis or bone infarcts. In the studied group, antinuclear antibodies were more frequent (25% vs. 16%). None of the patients with autoantibodies had clinical manifestations of autoimmune diseases. Autoantibodies were not correlated with treatment, genotype, or splenectomy, except for anticardiolipid, more frequent in splenectomized patients. In type 1 Gaucher disease, autoantibodies were more frequent compared to a healthy population. However, they were not associated with an increased prevalence of clinical active autoimmune diseases. Copyright © 2016 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

  14. Depression in primary care patients with coronary heart disease: baseline findings from the UPBEAT UK study.

    Paul Walters

    Full Text Available An association between depression and coronary heart disease is now accepted but there has been little primary care research on this topic. The UPBEAT-UK studies are centred on a cohort of primary patients with coronary heart disease assessed every six months for up to four years. The aim of this research was to determine the prevalence and associations of depression in this cohort at baseline.Participants with coronary heart disease were recruited from general practice registers and assessed for cardiac symptoms, depression, quality of life and social problems.803 people participated. 42% had a documented history of myocardial infarction, 54% a diagnosis of ischaemic heart disease or angina. 44% still experienced chest pain. 7% had an ICD-10 defined depressive disorder. Factors independently associated with this diagnosis were problems living alone (OR 5.49, 95% CI 2.11-13.30, problems carrying out usual activities (OR 3.71, 95% CI 1.93-7.14, experiencing chest pain (OR 3.27, 95% CI 1.58-6.76, other pains or discomfort (OR 3.39, 95% CI 1.42-8.10, younger age (OR 0.95 per year 95% CI 0.92-0.98.Problems living alone, chest pain and disability are important predictors of depression in this population.

  15. Study on the change of cyclic nucleotide in mice with yang vacuity disease

    Zhu Xinhua; Shen Ling; Wang Shuguang

    2002-01-01

    To study the relation between Yang Vacuity disease happening, development and cyclic nucleotide response, and prove curative effects of some assisting Yang drug, the plasma cAMP, cGMP and cAMP/cGMP levels were detected by radioimmunoassay in the Yang Vacuity group and curing group. Results: showed: (1) Yang Vacuity group: the symptoms were clear, death rate was high, the plasma cAMP and cAMP/cGMP increased obviously, it suggests that cyclic nucleotide was imbalance. (2) Curing group: the symptoms of Yang Vacuity disease were improved obviously, death rate dropped, cAMP declined, cGMP increased, while cAMP/cGMP reached the normal level, it showed that cyclic nucleotide of the body had altered greatly. (3) It is a reference target for Yang Vacuity. (4) Assisting yang drug (Sini Decoction) had a close relation with correcting imbalance of cyclic nucleotide

  16. The epidemiological modelling of dysthymia: application for the Global Burden of Disease Study 2010.

    Charlson, Fiona J; Ferrari, Alize J; Flaxman, Abraham D; Whiteford, Harvey A

    2013-10-01

    In order to capture the differences in burden between the subtypes of depression, the Global Burden of Disease 2010 Study for the first time estimated the burden of dysthymia and major depressive disorder separately from the previously used umbrella term 'unipolar depression'. A global summary of epidemiological parameters are necessary inputs in burden of disease calculations for 21 world regions, males and females and for the year 1990, 2005 and 2010. This paper reports findings from a systematic review of global epidemiological data and the subsequent development of an internally consistent epidemiological model of dysthymia. A systematic search was conducted to identify data sources for the prevalence, incidence, remission and excess-mortality of dysthymia using Medline, PsycINFO and EMBASE electronic databases and grey literature. DisMod-MR, a Bayesian meta-regression tool, was used to check the epidemiological parameters for internal consistency and to predict estimates for world regions with no or few data. The systematic review identified 38 studies meeting inclusion criteria which provided 147 data points for 30 countries in 13 of 21 world regions. Prevalence increases in the early ages, peaking at around 50 years. Females have higher prevalence of dysthymia than males. Global pooled prevalence remained constant across time points at 1.55% (95%CI 1.50-1.60). There was very little regional variation in prevalence estimates. There were eight GBD world regions for which we found no data for which DisMod-MR had to impute estimates. The addition of internally consistent epidemiological estimates by world region, age, sex and year for dysthymia contributed to a more comprehensive estimate of mental health burden in GBD 2010. © 2013 Elsevier B.V. All rights reserved.

  17. Burnout syndrome as an occupational disease in the European Union: an exploratory study.

    Lastovkova, Andrea; Carder, Melanie; Rasmussen, Hans Martin; Sjoberg, Lars; Groene, Gerda J de; Sauni, Riitta; Vevoda, Jiri; Vevodova, Sarka; Lasfargues, Gerard; Svartengren, Magnus; Varga, Marek; Colosio, Claudio; Pelclova, Daniela

    2018-04-07

    The risk of psychological disorders influencing the health of workers increases in accordance with growing requirements on employees across various professions. This study aimed to compare approaches to the burnout syndrome in European countries. A questionnaire focusing on stress-related occupational diseases was distributed to national experts of 28 European Union countries. A total of 23 countries responded. In 9 countries (Denmark, Estonia, France, Hungary, Latvia, Netherlands, Portugal, Slovakia and Sweden) burnout syndrome may be acknowledged as an occupational disease. Latvia has burnout syndrome explicitly included on the List of ODs. Compensation for burnout syndrome has been awarded in Denmark, France, Latvia, Portugal and Sweden. Only in 39% of the countries a possibility to acknowledge burnout syndrome as an occupational disease exists, with most of compensated cases only occurring in recent years. New systems to collect data on suspected cases have been developed reflecting the growing recognition of the impact of the psychosocial work environment. In agreement with the EU legislation, all EU countries in the study have an action plan to prevent stress at the workplace.

  18. Progress in studies of the reciprocal interaction between sleep disorders and Alzheimer's disease

    LIU Zhen-yu

    2013-06-01

    Full Text Available Alzheimer's disease (AD is a common neurodegenerative disease in the elderly, and is the most common cause of dementia. Epidemiological studies have discovered that, 44% of patients with AD are associated with sleep disorders and (or circadian rhythm disorders. Now there are growing evidences indicating that interstitial fluid amyloid-β protein (A β levels exhibit circadian rhythm fluctuation, and sleep disorders will accelerate the process of Aβ deposition, which may act as a risk factor of AD, suggesting the possible reciprocal interaction between sleep disorders and AD. The mechanism is not yet completely clear. Sleep disorders may be related with the impairments of both sleep-wake regulating system, circadian rhythm regulating system and the change of zeitgeber in AD. Sleep disorders would affect neuronal activity, neurotransmitter secretion, and as a stressor affecting A β processing and metabolism, thus accelerate the pathological process of AD. This paper reviewed the progress in the studies of reciprocal interaction between sleep disorders and Alzheimer's disease and the possible mechanisms.

  19. A study on periodontal disease and systemic disease relationship a hospital based study in Bangalore

    Sukhvinder Singh Oberoi

    2013-01-01

    Full Text Available Background: Periodontal deterioration has been reported to be associated with various systemic conditions like Cardiovascular disease, Diabetes, Respiratory disease, Liver cirrhosis, Bacterial Pneumonia, Nutritional deficiencies and adverse pregnancy outcomes. Aim: To assess the periodontal disease among patients with systemic disease/conditions. Materials and Method: A total of 500 patients with systemic disease/conditions (Diabetes, Cardiovascular disease, Respiratory disease and Renal disease and 500-age and gender matched controls without systemic disease/conditions were selected from the Government Hospitals in Bangalore City. The medical conditions were recorded and the periodontal status of the study population was assessed using the CPITN index. Results: The prevalence of CPITN Code 4 was found to be more among the patients with systemic disease/conditions (46.2%. The mean number of sextants with CPITN code 3 and 4 were more among the patients with systemic disease/conditions. The prevalence of CPITN code was found to be more among the patients with Respiratory disease whereas the mean number of sextants was found to be more among the patients with Diabetes, Cardiovascular and Renal disease. Conclusion: It may be concluded that the systemic diseases/conditions are associated with higher severity of periodontal disease.

  20. A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study.

    2002-12-01

    Monotherapy with rasagiline mesylate may be useful in early Parkinson disease (PD). To evaluate the safety and efficacy of the selective monoamine oxidase type B inhibitor rasagiline. Multicenter, 26-week, parallel-group, randomized, double-blind, placebo-controlled clinical trial. Academically based movement disorders clinics. Patients with early PD not requiring dopaminergic therapy (n = 404). Research participants were randomized to rasagiline mesylate at dosages of 1 mg or 2 mg per day or matching placebo. A 1-week escalation period was followed by a 25-week maintenance period. The primary prespecified measure of efficacy was the change in the total Unified Parkinson's Disease Rating Scal score between baseline and 26 weeks of treatment, comparing each active treatment group with the placebo group. Monotherapy with rasagiline was effective in this 26-week study. The adjusted effect size for the total Unified Parkinson's Disease Rating Scale was -4.20 units comparing 1 mg of rasagiline and placebo (95% confidence interval, -5.66 to -2.73 units; PRasagiline is effective as monotherapy for patients with early PD. The 2 dosages in this trial were both effective relative to placebo. Further study is warranted to evaluate the longer-term effects of rasagiline in PD.

  1. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010.

    Whiteford, Harvey A; Degenhardt, Louisa; Rehm, Jürgen; Baxter, Amanda J; Ferrari, Alize J; Erskine, Holly E; Charlson, Fiona J; Norman, Rosana E; Flaxman, Abraham D; Johns, Nicole; Burstein, Roy; Murray, Christopher J L; Vos, Theo

    2013-11-09

    We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to estimate the burden of disease attributable to mental and substance use disorders in terms of disability-adjusted life years (DALYs), years of life lost to premature mortality (YLLs), and years lived with disability (YLDs). For each of the 20 mental and substance use disorders included in GBD 2010, we systematically reviewed epidemiological data and used a Bayesian meta-regression tool, DisMod-MR, to model prevalence by age, sex, country, region, and year. We obtained disability weights from representative community surveys and an internet-based survey to calculate YLDs. We calculated premature mortality as YLLs from cause of death estimates for 1980-2010 for 20 age groups, both sexes, and 187 countries. We derived DALYs from the sum of YLDs and YLLs. We adjusted burden estimates for comorbidity and present them with 95% uncertainty intervals. In 2010, mental and substance use disorders accounted for 183·9 million DALYs (95% UI 153·5 million-216·7 million), or 7·4% (6·2-8·6) of all DALYs worldwide. Such disorders accounted for 8·6 million YLLs (6·5 million-12·1 million; 0·5% [0·4-0·7] of all YLLs) and 175·3 million YLDs (144·5 million-207·8 million; 22·9% [18·6-27·2] of all YLDs). Mental and substance use disorders were the leading cause of YLDs worldwide. Depressive disorders accounted for 40·5% (31·7-49·2) of DALYs caused by mental and substance use disorders, with anxiety disorders accounting for 14·6% (11·2-18·4), illicit drug use disorders for 10·9% (8·9-13·2), alcohol use disorders for 9·6% (7·7-11·8), schizophrenia for 7·4% (5·0-9·8), bipolar disorder for 7·0% (4·4-10·3), pervasive developmental disorders for 4·2% (3·2-5·3), childhood behavioural disorders for 3·4% (2·2-4·7), and eating disorders for 1·2% (0·9-1·5). DALYs varied by age and sex, with the highest proportion of total DALYs occurring in people aged 10

  2. Physical and cognitive stimulation in Alzheimer Disease. the GAIA Project: a pilot study.

    Maci, Tiziana; Pira, Francesco Le; Quattrocchi, Graziella; Nuovo, Santo Di; Perciavalle, Vincenzo; Zappia, Mario

    2012-03-01

    Several data suggest that physical activity and cognitive stimulation have a positive effect on the quality of life (QoL) of people with Alzheimer's disease (AD), slowing the decline due to the disease. A pilot project was undertaken to assess the effect of cognitive stimulation, physical activity, and socialization on patients with AD and their informal caregiver's QoL and mood. Fourteen patients with AD were randomly divided into active treatment group and control group. At the end of treatment, a significant improvement in apathy, anxiety, depression, and QoL in the active treatment group was found. Considering caregivers, those of the active treatment group exhibited a significant improvement in their mood and in their perception of patients' QoL. This study provides evidence that a combined approach based on cognitive stimulation, physical activity, and socialization is a feasible tool to improve mood and QoL in patients with AD and their caregivers.

  3. Atherosclerosis, apolipoprotein E and the prevalence of dementia and Alzheimer's disease in a population-based study: the Rotterdam Study

    A. Ott (Alewijn); M.L. Bots (Michiel); A.J.C. Slooter (Arjen); F. van Harskamp (Frans); C.M. van Duijn (Cornelia); D.E. Grobbee (Diederick); M.M.B. Breteler (Monique); C. van Broeckhoven (Christine); A. Hofman (Albert)

    1997-01-01

    textabstractBACKGROUND: Vascular disorders have been implicated in dementia, but whether atherosclerosis is related to the most frequent type of dementia, Alzheimer's disease, is not known. The apolipoprotein-E genotype has been associated with Alzheimer's disease, and we postulate that it plays a

  4. Study of Mobile GIS Application on the Field of GPR in the Road Disease Detection

    Liao, Q.; Yang, F.

    2013-12-01

    With the reflection principle of pulsed electromagnetic waves, ground penetrating radar (GPR) is available to measure depth of the pavement layer, reflecting different hidden danger underground. Currently, GPR has been widely used in road engineering with the constantly improved ability of detection and diagnosis to road diseases. The sum of road disease data of a region, a city, and even a wider range will be a very informative database, so we need a more convenient way to achieve data query intuitively. As mobile internet develops continuously, application of mobile terminal device plays a more important role in information platform. Mobile GIS, with smartphone as its terminal, is supported by the mobile Internet, GPS or base station as its positioning method. In this article, based on Android Platform and using C/S pattern, the LBS application of road diseases information which integrates Baidu Map API and database technology was discussed. After testing, it can display and query the real-time and historical road diseases data, the classification of data on a phone intuitively and easily. Because of the location technique and high portability of smart phone, the spot investigations of road diseases become easier. Though, the system needs further improvement, especially with the improving of the mobile phone performance, the system can also add the function of analysis to the disease data, thus forming a set of service system with more applicable.